Probing the Diversity of T Cell Dysfunction in Cancer.
T cell dysfunction in cancer comes in many forms, with two new varieties reported in this issue. Daley et al. find that T cells expressing γδ T cell receptors (TCR) promote pancreatic tumor growth by inhibiting activation of T cells with conventional TCRs. Singer et al. characterize dysfunctional tumor infiltrating lymphocytes to reveal a role for zinc homeostasis in anti-tumor immunity.
Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
Ryan T
RT
Sowell
Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA. Electronic address: susan.kaech@yale.edu.
Susan M
SM
Kaech
D006801:Humans; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology; D009369:Neoplasms / Q000276:immunology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D016692:Receptors, Antigen, T-Cell, gamma-delta