Perinatal neuroprotection update.
Antepartum, intrapartum, and neonatal events can result in a spectrum of long-term neurological sequelae, including cerebral palsy, cognitive delay, schizophrenia, and autism spectrum disorders [1]. Advances in obstetrical and neonatal care have led to survival at earlier gestational ages and consequently increasing numbers of periviable infants who are at significant risk for long-term neurological deficits. Therefore, efforts to decrease and prevent cerebral insults attempt not only to decrease preterm delivery but also to improve neurological outcomes in infants delivered preterm. We recently published a comprehensive review addressing the impacts of magnesium sulfate, therapeutic hypothermia, delayed cord clamping, infections, and prevention of preterm delivery on the modification of neurological risk [2]. In this review, we will briefly provide updates to the aforementioned topics as well as an expansion on avoidance of toxin and infections, specifically the Zika virus.
Department of Gynecology and Obstetrics, Johns Hopkins Hospital, Baltimore, MD, USA.
Angie C
AC
Jelin
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
Kirsten
K
Salmeen
Departments of Neurology & Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Dawn
D
Gano
Department of Gynecology and Obstetrics, Johns Hopkins Hospital, Baltimore, MD, USA.
Irina
I
Burd
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
Mari-Paule
MP
Thiet
Delayed umbilical cord clamping; Perinatal; Zika virus; neurological deficits; neuroprotection; preterm delivery