In situ precise electrospinning of medical glue fibers as nonsuture dural repair with high sealing capability and flexibility.
OBJECTIVE
In this work, we propose an in situ precise electrospinning of medical glue fibers onto dural wound for improving sealing capability, avoiding tissue adhesion, and saving time in dural repair.


METHODS
N-octyl-2-cyanoacrylate, a commercial tissue adhesive (medical glue), can be electrospun into ultrathin fibrous film with precise and homogeneous deposition by a gas-assisted electrospinning device.


RESULTS
The self-assembled N-octyl-2-cyanoacrylate film shows high compactness and flexibility owing to its fibrous structure. Simulation experiments on egg membranes and goat meninges demonstrated that this technology can repair small membrane defects quickly and efficiently.


CONCLUSIONS
This method may have potential application in dural repair, for example, working as an effective supplementary technique for conventional dura suture.
Collaborative Innovation Center for Nanomaterials & Optoelectronic Devices, College of Physics, Qingdao University.
Fu-Yan
FY
Lv
Collaborative Innovation Center for Nanomaterials & Optoelectronic Devices, College of Physics, Qingdao University.
Rui-Hua
RH
Dong
Department of Neurosurgery, Affiliated Hospital of Qingdao University.
Zhao-Jian
ZJ
Li
Collaborative Innovation Center for Nanomaterials & Optoelectronic Devices, College of Physics, Qingdao University.
Chong-Chong
CC
Qin
Collaborative Innovation Center for Nanomaterials & Optoelectronic Devices, College of Physics, Qingdao University; Industrial Research Institute of Nonwovens & Technical Textiles, College of Textiles & Clothing.
Xu
X
Yan
Collaborative Innovation Center for Nanomaterials & Optoelectronic Devices, College of Physics, Qingdao University.
Xiao-Xiao
XX
He
Medical College, Qingdao University, Qingdao, People's Republic of China.
Yu
Y
Zhou
Collaborative Innovation Center for Nanomaterials & Optoelectronic Devices, College of Physics, Qingdao University.
Shi-Ying
SY
Yan
Collaborative Innovation Center for Nanomaterials & Optoelectronic Devices, College of Physics, Qingdao University; Industrial Research Institute of Nonwovens & Technical Textiles, College of Textiles & Clothing.
Yun-Ze
YZ
Long
D000818:Animals; D002462:Cell Membrane / Q000737:chemistry; D003487:Cyanoacrylates / Q000737:chemistry*; D004388:Dura Mater / Q000502:physiology / Q000601:surgery*; D006041:Goats; D008578:Meninges / Q000502:physiology / Q000601:surgery; D008855:Microscopy, Electron, Scanning; D057139:Nanofibers / Q000737:chemistry*; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods*; D010063:Ovum / Q000166:cytology; D017550:Spectroscopy, Fourier Transform Infrared; D013537:Sutures; D000267:Tissue Adhesions / Q000517:prevention & control; D014014:Tissue Adhesives / Q000737:chemistry*; D014945:Wound Healing / Q000502:physiology
D003487:Cyanoacrylates; D014014:Tissue Adhesives; C100832:octyl 2-cyanoacrylate
cyanoacrylates; electrospun fibers; gas-assisted electrospinning apparatus; in situ repair dural