Modeling Pediatric Brain Trauma: Piglet Model of Controlled Cortical Impact.
The brain has different responses to traumatic injury as a function of its developmental stage. As a model of injury to the immature brain, the piglet shares numerous similarities in regards to morphology and neurodevelopmental sequence compared to humans. This chapter describes a piglet scaled focal contusion model of traumatic brain injury that accounts for the changes in mass and morphology of the brain as it matures, facilitating the study of age-dependent differences in response to a comparable mechanical trauma.
Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, 32610, USA. jennifermunozp@peds.ufl.edu.|Shands Children's Hospital, University of Florida, Gainesville, FL, 32610, USA. jennifermunozp@peds.ufl.edu.
Jennifer C Munoz
JC
Pareja
School of Medicine, Creighton University, Omaha, NE, 68178, USA.
Kristen
K
Keeley
Department of Neurosurgery, Harvard Medical School, Boston, MA, 02114, USA.|Massachusetts General Hospital, Boston, MA, 02114, USA.
Ann-Christine
AC
Duhaime
Department of Pediatric Anesthesia, Dartmouth Hitchcock, Lebanon, NH, 03766, USA.|Dartmouth Hitchcock Medical Center, Lebanon, NH, 03766, USA.
Carter P
CP
Dodge
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001706:Biopsy; D000070642:Brain Injuries, Traumatic / Q000209:etiology* / Q000473:pathology*; D002648:Child; D004195:Disease Models, Animal; D006801:Humans; D019635:Neurosurgical Procedures; D011182:Postoperative Care; D013552:Swine
Animal model; CCI; Controlled cortical impact; Development; Piglet; Swine; Traumatic brain injury