Diapeutic cancer-targeting alkylphosphocholine analogs may advance management of brain malignancies.
The following is a special report on alkylphosphocholine analogs as targeted imaging and therapy agents for cancer, and their potential role in diagnosis and treatment in glioblastoma and brain metastases. These novel cancer-targeting agents display impressive tumor avidity with low background in the normal brain, and multimodal diagnostic imaging and therapy capabilities. The use of these agents may significantly improve diagnosis, treatment and post-treatment follow-up in patients with brain malignancies.
Department of Neurological Surgery, University of Wisconsin, Madison, WI 53792, USA.|Department of Radiology, University of Wisconsin, Madison, WI 53705, USA.
Ray R
RR
Zhang
Department of Neurological Surgery, University of Wisconsin, Madison, WI 53792, USA.
Kyle I
KI
Swanson
Department of Radiology, University of Wisconsin, Madison, WI 53705, USA.
Lance T
LT
Hall
Department of Radiology, University of Wisconsin, Madison, WI 53705, USA.|Carbone Cancer Center, University of Wisconsin, Madison, WI 53792, USA.
Jamey P
JP
Weichert
Department of Neurological Surgery, University of Wisconsin, Madison, WI 53792, USA.|Carbone Cancer Center, University of Wisconsin, Madison, WI 53792, USA.
John S
JS
Kuo
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D019468:Disease Management; D005909:Glioblastoma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D064847:Multimodal Imaging; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D010767:Phosphorylcholine
cancer imaging; cancer therapy; contrast agents; fluorescence-guided surgery; glioblastoma multiforme; multimodality imaging; personalized medicine; theranostics