Protein Profiling of Bladder Urothelial Cell Carcinoma.
This study aimed to detect protein changes that can assist to understand the underlying biology of bladder cancer. The data showed forty five proteins were found to be differentially expressed comparing tumors vs non-tumor tissues, of which EGFR and cdc2p34 were correlated with muscle invasion and histological grade. Ten proteins (ß-catenin, HSP70, autotaxin, Notch4, PSTPIP1, DPYD, ODC, cyclinB1, calretinin and EPO) were able to classify muscle invasive BCa (MIBC) into 2 distinct groups, with group 2 associated with poorer survival. Finally, 3 proteins (P2X7, cdc25B and TFIIH p89) were independent factors for favorable overall survival.
Department of Urology, The First Hospital, Jilin University, Changchun, Jilin, 130021, China.
Jinghai
J
Hu
Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States of America.
Fei
F
Ye
Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States of America.
Miao
M
Cui
Departments of Pathology, New York University, School of Medicine, New York, NY, 10010, United States of America.
Peng
P
Lee
Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, NY, 10029, United States of America.
Chengguo
C
Wei
Department of Urology, The First Hospital, Jilin University, Changchun, Jilin, 130021, China.
Yuanyuan
Y
Hao
Department of Urology, The First Hospital, Jilin University, Changchun, Jilin, 130021, China.
Xiaoqing
X
Wang
Department of Urology, The First Hospital, Jilin University, Changchun, Jilin, 130021, China.
Yanbo
Y
Wang
Department of Urology, The First Hospital, Jilin University, Changchun, Jilin, 130021, China.
Zhihua
Z
Lu
Division of Hematology and Oncology, Department of Medicine, Mount Sinai School of Medicine, New York, NY, 10029, United States of America.
Matthew
M
Galsky
Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States of America.
Russell
R
McBride
Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, 10029, United States of America.
Li
L
Wang
Department of Urology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030002, China.
Dongwen
D
Wang
Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States of America.
Carlos
C
Cordon-Cardo
Department of Urology, The First Hospital, Jilin University, Changchun, Jilin, 130021, China.
Chunxi
C
Wang
Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States of America.
David Y
DY
Zhang
D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D040081:Protein Array Analysis / Q000379:methods; D015398:Signal Transduction; D059467:Transcriptome; D001749:Urinary Bladder Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D019459:Urothelium / Q000378:metabolism
D014408:Biomarkers, Tumor