Impact of Surgical Complications Following Resection of Locally Advanced Rectal Adenocarcinoma on Adjuvant Chemotherapy Delivery and Survival Outcomes.
BACKGROUND
Surgical complications after resection for locally advanced rectal cancer may influence adjuvant treatment outcomes and survival. Few studies have examined this effect.


OBJECTIVE
This study aimed to examine the impact of surgical complications on adjuvant therapy delivery and survival in patients with locally advanced rectal cancer treated with long-course chemoradiation followed by surgery.


METHODS
This is a retrospective analysis of a prospectively collected multicenter colorectal cancer database.


METHODS
Data were collected from the Australian Comprehensive Cancer Outcomes and Research Database.


METHODS
All patients who completed neoadjuvant chemoradiotherapy followed by surgery for locally advanced rectal cancer between January 2003 and December 2014 were selected.


METHODS
We examined the types and frequency of surgical complications and their impact on the delivery of adjuvant chemotherapy and survival.


RESULTS
Data were available for 517 patients, of whom 147 (28%) had a surgical complication. Patients with a surgical complication were less likely to commence adjuvant chemotherapy (33% vs 66%; p = 0.0005) and more likely to have adjuvant treatment commencing more than 8 weeks from surgery (71.8% vs 21.2%; p = 0.004). Wound-related complications (p = 0.001), return to operating theater (p = 0.004), and readmission within 30 days (p = 0.02) had the most significant negative impact on the delivery of adjuvant chemotherapy. Surgical complications were significantly more likely in males (31.6% vs 20.8%, p = 0.003) and laparoscopic converted cases (47.8% vs 21.8%, p = 0.03). For the entire patient population, adjuvant chemotherapy compared with surveillance was not associated with an improved recurrence-free survival (HR, 1.06; p = 0.83) but was associated with an improved overall survival (HR, 0.53; p = 0.04).


CONCLUSIONS
This study was limited by its retrospective design.


CONCLUSIONS
Surgical complications in patients having surgery following neoadjuvant chemoradiotherapy for locally advanced rectal cancer were associated with significantly reduced uptake and delays to receiving adjuvant therapy. Surgical complications, however, were not associated with either significantly reduced recurrence-free or overall survival. Adjuvant chemotherapy delivery was associated with improved overall survival.
1 Department of Surgery, Eastern Health, Melbourne, Australia 2 Department of Medical Oncology, Eastern Health, Melbourne, Australia 3 Department of Surgery, Royal Melbourne Hospital, Melbourne, Australia 4 Department of Surgery, Western Health, Melbourne, Australia 5 Department of Medical Oncology, Royal Melbourne Hospital, Melbourne, Australia 6 Department of Medical Oncology, Western Health, Melbourne, Australia 7 Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia 8 University of Melbourne, Melbourne, Australia 9 Monash University, Faculty of Medicine, Nursing and Health Sciences, Melbourne, Australia.
Murtaza
M
Jamnagerwalla
Rebecca
R
Tay
Malcolm
M
Steel
Jamie
J
Keck
Ian
I
Jones
Ian
I
Faragher
Peter
P
Gibbs
Rachel
R
Wong
D000230:Adenocarcinoma / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D000328:Adult; D000368:Aged; D001315:Australia / Q000453:epidemiology; D059186:Chemoradiotherapy, Adjuvant / Q000379:methods*; D003082:Colectomy / Q000009:adverse effects / Q000379:methods; D003131:Combined Modality Therapy / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000379:methods*; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011183:Postoperative Complications / Q000503:physiopathology / Q000628:therapy; D012004:Rectal Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology