Synthesis and biological evaluation of 4-(2-(dimethylamino)ethoxy)benzohydrazide derivatives as inhibitors of Entamoeba histolyica.
In the quest for potent antiamoebic agents, a series of hydrazone hybrids (H1H30) have been designed and sequentially synthesized. The dimethylaminoethoxy and hydrazone entities incorporated into one molecule proved to be more persuasive and selective approach towards designing of antiamoebic agent. The synthesized compounds exhibited promising results against E. histolytica. The compound N'-(2-chlorobenzylidene)-4-(2-(dimethylamino) ethoxy)benzohydrazide was most impending among the series. Cytotoxicity profile showed better cell viability on lung cancer cell line (A549 cells) by MTT assay.
Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, 110 025, New Delhi, India.
Afreen
A
Inam
School of Biotechnology, Jawaharlal Nehru University, New Delhi, 110067, India.
Sonam
S
Mittal
School of Biotechnology, Jawaharlal Nehru University, New Delhi, 110067, India.
Maitreyi S
MS
Rajala
Departamento de Química Fundamental, Universidade da Coruña, Campus da Zapateira, 15071 A Coruña, Spain.
Fernando
F
Avecilla
Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, 110 025, New Delhi, India. Electronic address: amir_sumbul@yahoo.co.in.
Amir
A
Azam
D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D045744:Cell Line, Tumor; D060326:Chemistry Techniques, Synthetic; D004353:Drug Evaluation, Preclinical; D004748:Entamoeba histolytica / Q000187:drug effects*; D006801:Humans; D006834:Hydrazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship
D000981:Antiprotozoal Agents; D006834:Hydrazines
Antiamoebic activity; Cytotoxicity; Hydrazones; MTT assay; X-ray crystallography