Paternal Mitochondrial Transmission in Intra-Species Caenorhabditis briggsae Hybrids.
To study mitochondrial-nuclear genetic interactions in the nematode Caenorhabditis briggsae, our three laboratories independently created 38 intra-species cytoplasmic-nuclear hybrid (cybrid) lines. Although the cross design combines maternal mitotypes with paternal nuclear genotypes, eight lines (21%) unexpectedly contained paternal mitotypes. All eight share in common ancestry of one of two genetically related strains. This unexpected parallel observation of paternal mitochondrial transmission, undesirable given our intent of creating cybrids, provides a serendipitous experimental model and framework to study the molecular and evolutionary basis of uniparental mitochondrial inheritance.
Department of Biology, California State University, Fresno, CA jross@csufresno.edu.
Joseph A
JA
Ross
Department of Integrative Biology, Oregon State University, Corvallis, OR.
Dana K
DK
Howe
Department of Biology, Portland State University, Portland, OR.|Institute of Ecology and Evolution, University of Oregon, Eugene, OR.
Anna
A
Coleman-Hulbert
Department of Integrative Biology, Oregon State University, Corvallis, OR.
Dee R
DR
Denver
Department of Biology, Portland State University, Portland, OR.
Suzanne
S
Estes
D000818:Animals; D002107:Caenorhabditis / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics; D004843:Epistasis, Genetic; D019143:Evolution, Molecular; D050259:Genes, Mitochondrial; D054629:Genome, Mitochondrial; D005838:Genotype; D006822:Hybrid Cells / Q000502:physiology; D008297:Male; D008928:Mitochondria / Q000235:genetics*; D000072740:Paternal Inheritance / Q000235:genetics*
D004272:DNA, Mitochondrial
coevolution; fertilization.; heteroplasmy; mitochondria; transmission