Safety and Preliminary Efficacy of Early Tirofiban Treatment After Alteplase in Acute Ischemic Stroke Patients.
We investigated whether early initiation of tirofiban, a glycoprotein IIb/IIIa antagonist, is safe, can reduce the risk of reocclusion, and improve outcomes in acute ischemic stroke patients after alteplase.



Forty-one patients received alteplase followed by intravenous tirofiban infusion for at least 24 hours. The incidence of symptomatic intracranial hemorrhage, systematic bleedings, and death was recorded. The National Institutes of Health stroke scale score was evaluated at 24 hours and at day 7 (or discharge). Modified Rankin scale was assessed at 3 months. Outcomes for these patients were compared with a propensity score-matched historical cohort with alteplase only.



The incidence of symptomatic intracranial hemorrhage, death, or systematic bleedings (P=1.00) was not increased in the alteplase/tirofiban group. At 24 hours, fewer patients experienced reocclusion in the alteplase/tirofiban group (2.4% versus 22.0%; P=0.025). At day 7 or discharge, the median National Institutes of Health stroke scale score was significantly lower in the alteplase/tirofiban group (1 versus 6; P=0.002). At 3 months, more patients had favorable outcomes of modified Rankin scale 0 to 1 (70.7% versus 46.2%; P=0.026).



Intravenous tirofiban immediately after alteplase seems to be safe and potentially more effective when compared with alteplase alone for selected stroke patients.



URL: http://www.chictr.org.cn/. Unique identifier: ChiCTR-TRC-14004630.
From the Department of Neurology (W.L., L.L., M.Z., Y.W., C.L., X.L., S.H., C.L., Y.W.) and Radiology (J.C.), Research Institute of Surgery, Daping Hospital, Third Military Medical University, China; and Department of Neurology, Medical University of South Carolina (W.F.).
Wei
W
Li
From the Department of Neurology (W.L., L.L., M.Z., Y.W., C.L., X.L., S.H., C.L., Y.W.) and Radiology (J.C.), Research Institute of Surgery, Daping Hospital, Third Military Medical University, China; and Department of Neurology, Medical University of South Carolina (W.F.).
Lu
L
Lin
From the Department of Neurology (W.L., L.L., M.Z., Y.W., C.L., X.L., S.H., C.L., Y.W.) and Radiology (J.C.), Research Institute of Surgery, Daping Hospital, Third Military Medical University, China; and Department of Neurology, Medical University of South Carolina (W.F.). zhangmeng861@gmail.com.
Meng
M
Zhang
From the Department of Neurology (W.L., L.L., M.Z., Y.W., C.L., X.L., S.H., C.L., Y.W.) and Radiology (J.C.), Research Institute of Surgery, Daping Hospital, Third Military Medical University, China; and Department of Neurology, Medical University of South Carolina (W.F.).
Ya
Y
Wu
From the Department of Neurology (W.L., L.L., M.Z., Y.W., C.L., X.L., S.H., C.L., Y.W.) and Radiology (J.C.), Research Institute of Surgery, Daping Hospital, Third Military Medical University, China; and Department of Neurology, Medical University of South Carolina (W.F.).
Chengchun
C
Liu
From the Department of Neurology (W.L., L.L., M.Z., Y.W., C.L., X.L., S.H., C.L., Y.W.) and Radiology (J.C.), Research Institute of Surgery, Daping Hospital, Third Military Medical University, China; and Department of Neurology, Medical University of South Carolina (W.F.).
Xiaoshu
X
Li
From the Department of Neurology (W.L., L.L., M.Z., Y.W., C.L., X.L., S.H., C.L., Y.W.) and Radiology (J.C.), Research Institute of Surgery, Daping Hospital, Third Military Medical University, China; and Department of Neurology, Medical University of South Carolina (W.F.).
Shuhan
S
Huang
From the Department of Neurology (W.L., L.L., M.Z., Y.W., C.L., X.L., S.H., C.L., Y.W.) and Radiology (J.C.), Research Institute of Surgery, Daping Hospital, Third Military Medical University, China; and Department of Neurology, Medical University of South Carolina (W.F.).
Chunrong
C
Liang
From the Department of Neurology (W.L., L.L., M.Z., Y.W., C.L., X.L., S.H., C.L., Y.W.) and Radiology (J.C.), Research Institute of Surgery, Daping Hospital, Third Military Medical University, China; and Department of Neurology, Medical University of South Carolina (W.F.).
Yanjiang
Y
Wang
From the Department of Neurology (W.L., L.L., M.Z., Y.W., C.L., X.L., S.H., C.L., Y.W.) and Radiology (J.C.), Research Institute of Surgery, Daping Hospital, Third Military Medical University, China; and Department of Neurology, Medical University of South Carolina (W.F.).
Jinhua
J
Chen
From the Department of Neurology (W.L., L.L., M.Z., Y.W., C.L., X.L., S.H., C.L., Y.W.) and Radiology (J.C.), Research Institute of Surgery, Daping Hospital, Third Military Medical University, China; and Department of Neurology, Medical University of South Carolina (W.F.).
Wuwei
W
Feng
D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging*; D002545:Brain Ischemia / Q000000981:diagnostic imaging / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D005343:Fibrinolytic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000000981:diagnostic imaging / Q000188:drug therapy*; D015912:Thrombolytic Therapy; D013997:Time Factors; D000077466:Tirofiban; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014443:Tyrosine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
D005343:Fibrinolytic Agents; D014443:Tyrosine; D010959:Tissue Plasminogen Activator; D000077466:Tirofiban
acute ischemic stroke; outcomes research; safety; tirofiban; tissue-type plasminogen activator