Columnaristerol A, a novel 19-norsterol from the Formosan octocoral Nephthea columnaris.
Columnaristerol A (1), a rare natural 19-norsterol possessing a 10β-hydroxy group was isolated from the Formosan octocoral Nephthea columnaris, and its structure was elucidated by spectroscopic methods. Sterol 1 was found to be a cytotoxic agent that exhibited in vitro moderate cytotoxic activity against MOLT-4 and SUP-T1 human leukemia-lymphoma cell lines.
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan; National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
Ta-Yuan
TY
Whuang
Medicine Department, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 833, Taiwan.
Wen-Cheng
WC
Tsai
Division of Neurosurgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 802, Taiwan; Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.
Nan-Fu
NF
Chen
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
Zhi-Cheng
ZC
Chen
Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan; Department of Obstetrics and Gynecology and Institute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan; Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan.
Kuan-Hao
KH
Tsui
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan; Doctoral Degree Program of Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan.
Zhi-Hong
ZH
Wen
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
Yin-Di
YD
Su
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan; Doctoral Degree Program of Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan.
Yu-Chia
YC
Chang
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan; Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan.
Yu-Hsin
YH
Chen
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan; National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
Mei-Chin
MC
Lu
Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan.
Lee-Shing
LS
Fang
Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan.
Jih-Jung
JJ
Chen
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan.
Tung-Ying
TY
Wu
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan; School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan; Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. Electronic address: yachwu@mail.cmu.edu.tw.
Yang-Chang
YC
Wu
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan; National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan; Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. Electronic address: pjsung@nmmba.gov.tw.
Ping-Jyun
PJ
Sung
D000818:Animals; D037421:Anthozoa / Q000378:metabolism*; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009654:Norsteroids / Q000737:chemistry* / Q000494:pharmacology*; D066244:Proton Magnetic Resonance Spectroscopy; D013261:Sterols / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013624:Taiwan
D009654:Norsteroids; D013261:Sterols; C000621713:columnaristerol A
19-Norsterol; Columnaristerol; Cytotoxicity; Nephthea columnaris