Mammalian Metallothionein-2A and Oxidative Stress.
Mammalian metallothionein-2A (MT2A) has received considerable attention in recent years due to its crucial pathophysiological role in anti-oxidant, anti-apoptosis, detoxification and anti-inflammation. For many years, most studies evaluating the effects of MT2A have focused on reactive oxygen species (ROS), as second messengers that lead to oxidative stress injury of cells and tissues. Recent studies have highlighted that oxidative stress could activate mitogen-activated protein kinases (MAPKs), and MT2A, as a mediator of MAPKs, to regulate the pathogenesis of various diseases. However, the molecule mechanism of MT2A remains elusive. A deeper understanding of the functional, biochemical and molecular characteristics of MT2A would be identified, in order to bring new opportunities for oxidative stress therapy.
Department of Cardiovascular Institute, Affiliated Hospital of Hainan Medical College, Haikou 570102, China. xuebin192006@163.com.
Xue-Bin
XB
Ling
Department of Cardiovascular Institute, Affiliated Hospital of Hainan Medical College, Haikou 570102, China. aida1860@163.com.
Hong-Wei
HW
Wei
Department of Cardiovascular Institute, Affiliated Hospital of Hainan Medical College, Haikou 570102, China. doctorwangjun@126.com.
Jun
J
Wang
Department of Cardiovascular Institute, Affiliated Hospital of Hainan Medical College, Haikou 570102, China. kongyueqiong1@medmail.com.cn.
Yue-Qiong
YQ
Kong
Department of Cardiovascular Institute, Affiliated Hospital of Hainan Medical College, Haikou 570102, China. wuyuyou76@163.com.
Yu-You
YY
Wu
Department of Cardiovascular Institute, Affiliated Hospital of Hainan Medical College, Haikou 570102, China. guojl79@163.com.
Jun-Li
JL
Guo
Department of Cardiovascular Institute, Affiliated Hospital of Hainan Medical College, Haikou 570102, China. litf79997@aliyun.com.
Tian-Fa
TF
Li
Department of Cardiovascular Institute, Affiliated Hospital of Hainan Medical College, Haikou 570102, China. jike0335@163.com.
Ji-Ke
JK
Li
D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism; D006801:Humans; D020935:MAP Kinase Signaling System; D008668:Metallothionein / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism; D009422:Nervous System Diseases / Q000378:metabolism; D018384:Oxidative Stress
D008668:Metallothionein
metallothionein-2A; mitogen-activated protein kinases; oxidative stress; reactive oxygen species