The glycosylation stoichiometry of EWS species in neuronal cells.
Although Ewing sarcoma protein (EWS) is known to be glycosylated by O-linked β-N-acetylglucosamine (O-GlcNAc), the dynamics and stoichiometry of its glycosylation remain obscure. Here, we report a dynamic change in the glycosylation stoichiometry of EWS species during neuronal differentiation of embryonic carcinoma P19 cells. Our findings suggest that O-GlcNAc glycosylation participates in the regulation of EWS functions in neuronal cells.
a Department of Bioscience , Nagahama Institute of Bio-Science and Technology , Nagahama , Japan.
Kazuo
K
Kamemura
a Department of Bioscience , Nagahama Institute of Bio-Science and Technology , Nagahama , Japan.
Hiromi
H
Abe
D000818:Animals; D002454:Cell Differentiation; D045744:Cell Line, Tumor; D006031:Glycosylation; D051379:Mice; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D034802:RNA-Binding Protein EWS / Q000378:metabolism*
D034802:RNA-Binding Protein EWS
EWS; O-GlcNAc; chemoenzymatic labeling; glycosylation stoichiometry; neuronal differentiation