Increased migraine risk in osteoporosis patients: a nationwide population-based study.
BACKGROUND
Osteoporosis and migraine are both important public health problems and may have overlapping pathophysiological mechanisms. The aim of this study was to use a Taiwanese population-based dataset to assess migraine risk in osteoporosis patients.


METHODS
The Taiwan National Health Insurance Research Database was used to analyse data for 40,672 patients aged ≥20 years who had been diagnosed with osteoporosis during 1996-2010. An additional 40,672 age-matched patients without osteoporosis were randomly selected as the non-osteoporosis group. The relationship between osteoporosis and migraine risk was estimated using Cox proportional hazard regression models.


RESULTS
During the follow-up period, 1110 patients with osteoporosis and 750 patients without osteoporosis developed migraine. After controlling for covariates, the overall incidence of migraine was 1.37-fold higher in the osteoporosis group than in the non-osteoporosis group (3.72 vs. 1.24 per 1000 person-years, respectively). Migraine risk factors included high Charlson Comorbidity Index score, female gender, hypertension, depression, asthma, allergic rhinitis, obesity, and tobacco use disorder.


CONCLUSIONS
Our results indicate that patients with a history of osteoporosis had a higher risk of migraine.
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.|Department of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100 Tzyou 1st Road, Kaohsiung, 80708 Taiwan.
Chieh-Hsin
CH
Wu
Department of Neurosurgery, The No. 7 People's Hospital of Hebei Province, Dingzhou, 073000 Hebei People's Republic of China.
Zi-Hao
ZH
Zhang
Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, 807 Taiwan.
Ming-Kung
MK
Wu
Department of Nursing, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100 Tzyou 1st Road, Kaohsiung, 80708 Taiwan.
Chiu-Huan
CH
Wang
Department of Dermatology, Kaohsiung Veterans General Hospital, No. 386 Dazhong 1st Rd, Kaohsiung, 81362 Taiwan.|Cosmetic Applications and Management Department, Yuh-Ing Junior College of Health Care and Management, Kaohsiung, Taiwan.
Ying-Yi
YY
Lu
Department of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100 Tzyou 1st Road, Kaohsiung, 80708 Taiwan.|Department of Neurosurgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chih-Lung
CL
Lin
Migraine; Nationwide population-based study; Osteoporosis