Low serum magnesium levels are associated with impaired peripheral nerve function in type 2 diabetic patients.
The aim of this study was to explore the relationship between serum magnesium and peripheral nerve function in patients with type 2 diabetes (T2DM). A total of 978 T2DM patients were included in the study. Patients were divided into tertiles according to serum magnesium concentration (low tertile: ≤0.85 mmol/L; medium tertile: 0.85 to 0.92 mmol/L; and high tertile: >0.92 mmol/L). All participants underwent nerve conduction (NC) studies. Composite z scores of conduction velocity, latency, and amplitude were constructed, respectively. The serum magnesium levels were significantly lower in patients with abnormal NC than in those with normal NC (0.87 [0.82, 0.92] vs. 0.88 [0.83, 0.93] mmol/L, P = 0.048). The composite z score of amplitude significantly increased with increasing tertiles of magnesium (-0.60 ± 0.02 vs. -0.57 ± 0.02 vs. -0.48 ± 0.03, P for trend = 0.001). After adjusting for all potential confounders, lower serum magnesium levels were still associated with lower composite z score of amplitude (β = 0.095, P = 0.014). In patients with T2DM, lower serum magnesium levels were significantly associated with lower composite z score of amplitude, indicating magnesium might affect peripheral nerve function through axonal degeneration.
Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, 600 Yishan Road, Shanghai 200233, People's Republic of China.
Chen
C
Chu
Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, 600 Yishan Road, Shanghai 200233, People's Republic of China.
Weijing
W
Zhao
Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Center for Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, The Metabolic Diseases Biobank, Shanghai, 200233, People's Republic of China.
Yinan
Y
Zhang
Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, 600 Yishan Road, Shanghai 200233, People's Republic of China.
Lu
L
Li
Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, 600 Yishan Road, Shanghai 200233, People's Republic of China.
Jingyi
J
Lu
Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Department of Electrophysiology, Shanghai, 200233, People's Republic of China.
Lan
L
Jiang
Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, 600 Yishan Road, Shanghai 200233, People's Republic of China.
Congrong
C
Wang
Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, 600 Yishan Road, Shanghai 200233, People's Republic of China.
Weiping
W
Jia
D016022:Case-Control Studies; D003710:Demography; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008274:Magnesium / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D010525:Peripheral Nerves / Q000503:physiopathology*
D008274:Magnesium