Maternal high-fat diet inversely affects insulin sensitivity in dams and young adult male rat offspring.
This study attempts to further clarify the potential effects of maternal high-fat (HF) diet on glucose homeostasis in dams and young adult male rat offspring. Female rats were divided into control (CON dams) and HF (HF dams) diet groups, which received the diet 4 weeks prior to and through pregnancy and lactation periods. Blood samples were taken to determine metabolic parameters, then an intraperitoneal glucose tolerance test (IPGTT) was performed. Maternal HF diet increased intra-abdominal fat mass and plasma corticosterone level, but decreased leptin concentration in dams. In HF offspring intra-abdominal fat mass, plasma leptin, and corticosterone levels decreased. Following IPGTT, the plasma insulin level of HF dams was higher than the controls. In HF offspring plasma insulin level was not significantly different from the controls, but a steeper decrease of their plasma glucose concentration was observed.
Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Roxana
R
Karbaschi
Education Development Center, Mazandaran University of Medical Sciences, Sari, Iran.
Forouzan
F
Sadeghimahalli
Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.|Neurophysiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Homeira
H
Zardooz
D000821:Animal Feed; D000818:Animals; D059305:Diet, High-Fat / Q000009:adverse effects*; D004041:Dietary Fats; D005260:Female; D005947:Glucose / Q000378:metabolism; D005951:Glucose Tolerance Test; D006706:Homeostasis; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D007774:Lactation; D020738:Leptin / Q000097:blood; D008297:Male; D018811:Maternal Exposure; D009765:Obesity / Q000150:complications; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats
D004041:Dietary Fats; D007328:Insulin; D020738:Leptin; D005947:Glucose
Corticosterone; Glucose tolerance test; Homeostasis model assessment of insulin resistance (HOMA-IR); Insulin; Maternal high-fat diet