Associations between Dietary Nutrient Intakes and Hepatic Lipid Contents in NAFLD Patients Quantified by ¹H-MRS and Dual-Echo MRI.
Dietary habits are crucial in the progression of hepatic lipid accumulation and nonalcoholic fatty liver disease (NAFLD). However, there are limited studies using ¹H-magnetic resonance spectroscopy (¹H-MRS) and dual-echo in-phase and out-phase magnetic resonance spectroscopy imaging (dual-echo MRI) to assess the effects of dietary nutrient intakes on hepatic lipid contents. In the present study, we recruited 36 female adults (NAFLD:control = 19:17) to receive questionnaires and medical examinations, including dietary intakes, anthropometric and biochemical measurements, and ¹H-MRS and dual-echo MRI examinations. NAFLD patients were found to consume diets higher in energy, protein, fat, saturated fatty acid (SFA), and polyunsaturated fatty acid (PUFA). Total energy intake was positively associated with hepatic fat fraction (HFF) and intrahepatic lipid (IHL) after adjustment for age and body-mass index (BMI) (HFF: β = 0.24, p = 0.02; IHL: β = 0.38, p = 0.02). Total fat intake was positively associated with HFF and IHL after adjustment for age, BMI and total energy intake (HFF: β = 0.36, p = 0.03; IHL: β = 0.42, p = 0.01). SFA intake was positively associated with HFF and IHL after adjustments (HFF: β = 0.45, p = 0.003; IHL: β = 1.16, p = 0.03). In conclusion, hepatic fat content was associated with high energy, high fat and high SFA intakes, quantified by ¹H-MRS and dual-echo MRI in our population. Our findings are useful to provide dietary targets to prevent the hepatic lipid accumulation and NAFLD.
Department of Magnetic Resonance Imaging, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China. fanyun_strivecyp@sina.com.
Yipeng
Y
Cheng
Department of Mathematics, Heilongjiang Institute of Technology, Harbin 150027, China. zhangkewei2005@163.com.
Kewei
K
Zhang
Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150086, China. liushn0505@163.com.
Yang
Y
Chen
Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150086, China. liyanchuan2013@foxmail.com.
Yanchuan
Y
Li
Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150086, China. 15130143180@126.com.
Yuzheng
Y
Li
Department of Magnetic Resonance Imaging, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China. Fukuang4858637@163.com.
Kuang
K
Fu
Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150086, China. fengrennan@163.com.
Rennan
R
Feng
D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002681:China; D000072001:Diet, Healthy; D004041:Dietary Fats / Q000008:administration & dosage* / Q000009:adverse effects; D002149:Energy Intake; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D008055:Lipids / Q000032:analysis*; D008099:Liver / Q000737:chemistry* / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000000981:diagnostic imaging / Q000209:etiology* / Q000378:metabolism; D009752:Nutritional Status; D066244:Proton Magnetic Resonance Spectroscopy; D011795:Surveys and Questionnaires
D004041:Dietary Fats; D008055:Lipids
1H-MRS; NAFLD; dietary nutrient intakes; dual-echo MRI