Nanomaterials for the Treatment of Bacterial Biofilms.
Treatment of biofilm-associated infections is challenging, requiring the development of new therapeutic strategies. In this viewpoint, we discuss the use of nanoparticle-based systems as active therapeutic agents and as vehicles to transport drugs to the site of infection. These applications require understanding of the surface interactions of nanoparticles with bacteria/biofilms, an aspect that we likewise summarize.
Department of Chemistry, University of Massachusetts-Amherst , 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.
Li-Sheng
LS
Wang
Department of Chemistry, University of Massachusetts-Amherst , 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.
Akash
A
Gupta
Department of Chemistry, University of Massachusetts-Amherst , 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.
Vincent M
VM
Rotello
D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D001672:Biocompatible Materials / Q000737:chemistry; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D016503:Drug Delivery Systems / Q000639:trends; D024881:Drug Resistance, Bacterial / Q000187:drug effects*; D006801:Humans; D050997:Nanomedicine / Q000639:trends*; D049329:Nanostructures / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D013499:Surface Properties
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials