Neurodegenerative diseases linked to misfolded proteins and their therapeutic approaches: A review.
Neurodegenerative diseases, such as Alzheimer's, Parkinson's, Creutzfeldt-Jacob, Huntington's diseases and amyotrophic lateral sclerosis, are mainly characterized by the massive deposition of misfolded protein aggregates consequent to aberrant production or overexpression of specific proteins. The development of new therapeutics for the treatment of neurodegenerative pathophysiologies currently stands at a crossroads. This presents an opportunity to transition future drug discovery efforts to target disease modification, an area in which much still remains unknown. In this review we examine recent progress in the area of neurodegenerative drug discovery, focusing on some of the most common targets.
Steroid Research Laboratory, Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India. Electronic address: henak055@gmail.com.
Hena
H
Khanam
Steroid Research Laboratory, Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India.
Abad
A
Ali
Steroid Research Laboratory, Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India.
Mohd
M
Asif
Steroid Research Laboratory, Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India. Electronic address: shamsuzzaman9@gmail.com.
Shamsuzzaman
D000818:Animals; D006801:Humans; D019636:Neurodegenerative Diseases / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism / Q000628:therapy*; D057165:Proteostasis Deficiencies / Q000150:complications*
Alzheimer's disease; Neurodegenerative; Perkinson's disease; Prions; Protein misfolding