The Lung Function Impairment in Non-Atopic Patients With Chronic Rhinosinusitis and Its Correlation Analysis.
OBJECTIVE
Chronic rhinosinusitis (CRS) is common disease in otorhinolaryngology and will lead to lower airway abnormality. However, the only lung function in CRS patients and associated factors have not been much studied.


METHODS
One hundred patients with CRS with nasal polyps (CRSwNP group), 40 patients with CRS without nasal polyps (CRSsNP group), and 100 patients without CRS were enrolled. The difference in lung function was compared. Meanwhile, CRSwNP and CRSsNP group were required to undergo a bronchial provocation or dilation test. Additionally, subjective and objective outcomes were measured by the visual analogue scale (VAS), 20-item Sino-Nasal Outcome Test (SNOT-20), Lund-Mackay score, Lund-Kennedy endoscopic score. The correlation and regression methods were used to analyze the relationship between their lung function and the above parameters.


RESULTS
The forced expiratory volume in 1 second (FEV1) and forced expiratory flow between 25% and 75% of forced vital capacity (FEF25-75) of CRSwNP group were significantly lower than other groups (P<0.05). On peak expiratory flow, there was no difference between three groups. In CRSwNP group, FEV1was negatively correlated with peripheral blood eosinophil count (PBEC) and duration of disease (r=-0.348,P=0.013 andr=-0.344,P=0.014, respectively), FEF25-75negatively with VAS, SNOT-20 (r=-0.490,P=0.028 andr=-0.478,P=0.033, respectively) in CRSsNP group. The incidence of positive bronchial provocation and dilation test was lower in CRSwNP group (10% and 0%, respectively), with both 0% in CRSsNP group. The multiple linear regression analysis indicated that change ratio of FEV1before and after bronchial provocation or dilation test were correlated with PBEC in CRSwNP group (β=0.403,P=0.006).


CONCLUSIONS
CRS leading to impaired maximum ventilation and small airway is associated with the existence of nasal polyp. Lung function impairments can be reflected by PBEC, duration, VAS, and SNOT-20. In CRSwNP patients, PBEC is independent predictor of FEV1change ratio.
Department of Otolaryngology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Linghao
L
Zhang
Department of Otolaryngology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Lu
L
Zhang
Department of Otolaryngology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Chun-Hong
CH
Zhang
Department of Otolaryngology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Xiao-Bi
XB
Fang
Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Ministry of Education, Beijing, China.
Zhen-Xiao
ZX
Huang
Department of Otolaryngology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Qing-Yuan
QY
Shi
Department of Otolaryngology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Li-Ping
LP
Wu
Department of Otolaryngology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Peng
P
Wu
Department of Otolaryngology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Zhen-Zhen
ZZ
Wang
Department of Otolaryngology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Zhi-Su
ZS
Liao
Bronchial Hyperreactivity; Bronchial Provocation Tests; Chronic Rhinosinusitis; Lung Function