Assessment of hormonal activity in patients with premature ejaculation.
OBJECTIVE
Premature ejaculation is considered the most common type of male sexual dysfunction. Hormonal controls of ejaculation have not been exactly elucidated. The aim of our study is to investigate the role of hormonal factors in patients with premature ejaculation.


METHODS
Sixty-three participants who consulted our outpatient clinics with complaints of premature ejaculation and 39 healthy men as a control group selected from volunteers were included in the study. A total of 102 sexual active men aged between 21 and 76 years were included. Premature ejaculation diagnostic tool questionnaires were used to assessment of premature ejaculation. Serum levels of follicle stimulating hormone, luteinizing hormone, prolactin, total and free testosterone, thyroid-stimulating hormone, free triiodothyronine and thyroxine were measured.


RESULTS
Thyroid-stimulating hormone, luteinizing hormone, and prolactin levels were significantly lower in men with premature ejaculation according to premature ejaculation diagnostic tool (p=0.017, 0.007 and 0.007, respectively). Luteinizing hormone level (OR, 1.293; p=0.014) was found to be an independent risk factor for premature ejaculation.


CONCLUSIONS
Luteinizing hormone, prolactin, and thyroid-stimulating hormone levels are associated with premature ejaculation which was diagnosed by premature ejaculation diagnostic tool questionnaires. The relationship between these findings have to be determined by more extensive studies.
Department of Urology, Okmeydani Training and Research Hospital, Istanbul, Turkey.
Lutfi
L
Canat
Department of Urology, Haseki Training and Research Hospital, Istanbul, Turkey.
Akif
A
Erbin
Department of Endocrinology, Bayburt State Hospital, Bayburt, Turkey.
Masum
M
Canat
Department of Urology, Kastamonu State Hospital, Kastamonu, Turkey.
Mehmet
M
Dinek
Department of Urology, Istanbul Medeniyet University Göztepe Training and Research Hospital, Istanbul, Turkey.
Turhan
T
Caskurlu
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D006728:Hormones / Q000097:blood*; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D061686:Premature Ejaculation / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D011446:Prospective Studies; D012016:Reference Values; D012307:Risk Factors; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D055815:Young Adult
D015415:Biomarkers; D006728:Hormones
Erectile Dysfunction; Hormones; Premature Ejaculation 