Next-Generation Sequencing and the Return of Results.
The impact of next-generation sequencing (NGS) on the issue of return of results is defying clear policy guidance and creating international confusion. Limiting ourselves to the return of results revealed by NGS (including incidental findings) in adults, children, family members of deceased individuals, and population studies, we describe and contrast emerging policy positions in Europe, Canada, and the United States. Until there are clear, scientific, and professional standards and practical policy, both researchers and clinicians cannot be faulted for being either hesitant or pressured to return NGS results.
Centre of Genomics and Policy, McGill University, Montreal, Quebec H3A 0G1, Canada.
Bartha Maria
BM
Knoppers
Centre of Genomics and Policy, McGill University, Montreal, Quebec H3A 0G1, Canada.
Minh Thu
MT
Nguyen
Centre of Genomics and Policy, McGill University, Montreal, Quebec H3A 0G1, Canada.
Karine
K
Sénécal
Public Population Project in Genomics and Society (PG), Montreal, Quebec H3A 0G1, Canada.
Anne Marie
AM
Tassé
Centre of Genomics and Policy, McGill University, Montreal, Quebec H3A 0G1, Canada.
Ma'n H
MH
Zawati
D000328:Adult; D002648:Child; D005190:Family; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D033162:Incidental Findings; D017410:Practice Guidelines as Topic; D017422:Sequence Analysis, DNA / Q000592:standards*