Clinical behavior of solitary fibrous tumor: a retrospective review of 30 patients.
BACKGROUND
Solitary fibrous tumors (SFTs) are a rare type of soft tissue sarcoma of unpredictable clinical behavior. Some clinicopathologic characteristics have also been related to patient outcome.


METHODS
This study is a retrospective review of 30 patients. We analyzed the clinical course and pathological factors to predict recurrence.


RESULTS
The mean age was 55.9 years. Forty-five percent were located in the thoracic region. The mean tumor size was 10 cm (max24). Thirty-three percent had a relapse and 20 % have died. Median time to relapse was 7.18 (1-13) years. Median overall survival (OS) was 15.5 years (0-32). On histopathologic analysis, 6 % percent had >4 mitoses, 23 % had necroses, and 36 % had atypia/pleomorphism. Forty-three percent had tumor size >10 cm. Forty-six percent had at least one characteristic of malignancy. None of this data could predict clinical behavior by itself.


CONCLUSIONS
SFT can be an aggressive disease and relapses can occur several years from diagnosis. We did not find any clinicopathologic factors that could predict the tumor behavior accurately. Nevertheless, it should be consider that we included different tumor locations and the sample size is small.
Medical Oncology Department, Ramón y Cajal University Hospital, Carretera de Colmenar Km 9,100, 28034, Madrid, Spain. mavaz4@gmail.com.
Mª A
MA
Vaz Salgado
Medical Oncology Department, Hospital General de Segovia, Segovia, Spain.
M
M
Soto
Pathlogy Department, Ramón y Cajal University Hospital, Madrid, Spain.
Mª E
ME
Reguero
Thoraric Surgery Department, Ramón y Cajal University Hospital, Madrid, Spain.
G
G
Muñoz
Thoraric Surgery Department, Ramón y Cajal University Hospital, Madrid, Spain.
A
A
Cabañero
Radiology Department, Ramón y Cajal University Hospital, Madrid, Spain.
I
I
Gallego
Radiology Department, Ramón y Cajal University Hospital, Madrid, Spain.
S
S
Resano
Medical Oncology Department, Ramón y Cajal University Hospital, Carretera de Colmenar Km 9,100, 28034, Madrid, Spain.
F
F
Longo
Medical Oncology Department, Ramón y Cajal University Hospital, Carretera de Colmenar Km 9,100, 28034, Madrid, Spain.
A
A
Madariaga
Medical Oncology Department, Ramón y Cajal University Hospital, Carretera de Colmenar Km 9,100, 28034, Madrid, Spain.
A
A
Gomez
Medical Oncology Department, Ramón y Cajal University Hospital, Carretera de Colmenar Km 9,100, 28034, Madrid, Spain.
A
A
Carrato
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D012983:Soft Tissue Neoplasms / Q000473:pathology*; D054364:Solitary Fibrous Tumors / Q000473:pathology*; D015996:Survival Rate; D055815:Young Adult
Chemotherapy; Pathology; Sarcoma; Solitary fibrous tumor; Tumor biology