[Correlation between clinical and laboratory criteria of suspected Hantavirus cases and the results of the reference diagnostic technique].
BACKGROUND
Currently in Chile, due to the frequent clinical suspicion of Hantavirus disease and the high public health impact that this causes, it is necessary to strengthen the criteria for clinical and epidemiological suspicion in the health team.


OBJECTIVE
To analyze the information contained in the reports of suspected Hantavirus infection versus the confirmatory diagnosis with the reference technique, IgM capture ELISA anti-hantavirus. Material andMethods: Correlation between the information provided in notifications versus the result of confirmation was analyzed by calculating diagnostic accuracy.


RESULTS
3.4% of 1,566 patients studied (53 cases) was confirmed as SCPH. 58.6% of the analyzed notifications was incomplete. The percentage of positivity of the reference technique associated with fever, myalgia and headache was 80-85%. The presence of immunoblasts (> 10%) showed 25% sensitivity, 98% specificity, 37% PPV, 97% NPV. Thrombocytopenia exhibited 98% sensitivity, 74% specificity, 16% PPV, 100% NPV.


CONCLUSIONS
It is necessary to reinforce the importance of comprehensive data reporting at the health system level. The presence of thrombocytopenia and immunoblasts (> 10%) is highly sensitive and specific, respectively, for detecting patients with SCPH. There is a need to develop training programs in order to optimize the suspicion of Hantavirus infection and appropriate use of health resources.
Instituto de Microbiología Clínica, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile, cotth@uach.cl.
Maritza
M
Navarrete
Instituto de Microbiología Clínica, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile, cotth@uach.cl.
Melissa
M
Hott
Instituto de Microbiología Clínica, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile, cotth@uach.cl.
Jorge
J
Caroca
Instituto de Microbiología Clínica, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile, cotth@uach.cl.
Luis
L
Leyton
Secretaría Regional Ministerio de Salud, Chile.
Nadialett
N
Venegas
Secretaría Regional Ministerio de Salud, Chile.
Kissy
K
Ismail
Instituto de Microbiología Clínica, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile.
Farides
F
Saavedra
Instituto de Microbiología Clínica, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile, cotth@uach.cl.
Carola
C
Otth
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002677:Chile; D018563:Disease Notification / Q000592:standards*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D018063:Hantaan virus / Q000302:isolation & purification*; D018804:Hantavirus Pulmonary Syndrome / Q000097:blood / Q000175:diagnosis*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007223:Infant; D008297:Male; D008875:Middle Aged; D012015:Reference Standards; D012016:Reference Values; D012680:Sensitivity and Specificity; D016036:Seroepidemiologic Studies; D012698:Serologic Tests / Q000379:methods; D013921:Thrombocytopenia / Q000097:blood / Q000175:diagnosis; D055815:Young Adult
D000914:Antibodies, Viral; D007075:Immunoglobulin M