Antimicrobial and quorum sensing inhibitory activities of the pericarp of Garcinia mangostana.
A prenylated xanthone, α-mangostin was separated from the alcoholic extract of Garcinia mangostana pericarp. Its structure was established by different spectroscopic analysis. The total methanolic extract (TME) and different fractions of G. mangostana pericarp as well as α-mangostin were assessed for their antimicrobial and quorum sensing inhibitory effects (QSI). The TME, CHCl3 fraction, and α-mangostin exhibited strong activity against all tested strains. While, EtOAc, n-BuOH, and aqueous fractions showed moderate activity against some of the tested organisms. In addition TME, CHCl3, EtOAc, and α-mangostin showed promising QSI, while n-BuOH and aqueous fractions showed moderate activity. Minimal inhibitory concentration (MIC) for TME, CHCl3 fractions, and α-mangostin was also assessed.
Department of Medical Microbiology and Parasitology, Faculty of Medicine, Princess Al-Jawhara Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia.
Hani Z
HZ
Asfour
D020001:1-Butanol; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002725:Chloroform; D005638:Fruit / Q000737:chemistry; D005658:Fungi / Q000187:drug effects; D029762:Garcinia mangostana / Q000737:chemistry*; D000432:Methanol; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology*; D053038:Quorum Sensing / Q000187:drug effects*; D012997:Solvents; D044004:Xanthones / Q000494:pharmacology
D000890:Anti-Infective Agents; D010936:Plant Extracts; D012997:Solvents; D044004:Xanthones; D002725:Chloroform; D020001:1-Butanol; C021053:mangostin; D000432:Methanol