Cyanobacterial metabolic engineering for biofuel and chemical production.
Rising levels of atmospheric CO2are contributing to the global greenhouse effect. Large scale use of atmospheric CO2may be a sustainable and renewable means of chemical and liquid fuel production to mitigate global climate change. Photosynthetic organisms are an ideal platform for efficient, natural CO2conversion to a broad range of chemicals. Cyanobacteria are especially attractive for these purposes, due to their genetic malleability and relatively fast growth rate. Recent years have yielded a range of work in the metabolic engineering of cyanobacteria and have led to greater knowledge of the host metabolism. Understanding of endogenous and heterologous carbon regulation mechanisms leads to the expansion of productive capacity and chemical variety. This review discusses the recent progress in metabolic engineering of cyanobacteria for biofuel and bulk chemical production since 2014.
Department of Chemistry, University of California, Davis, One Shields Ave, Davis, CA 95616, USA.
Neal J
NJ
Oliver
Department of Chemistry, University of California, Davis, One Shields Ave, Davis, CA 95616, USA.
Christine A
CA
Rabinovitch-Deere
Department of Chemistry, University of California, Davis, One Shields Ave, Davis, CA 95616, USA.
Austin L
AL
Carroll
Department of Chemistry, University of California, Davis, One Shields Ave, Davis, CA 95616, USA.
Nicole E
NE
Nozzi
Department of Chemistry, University of California, Davis, One Shields Ave, Davis, CA 95616, USA.
Anna E
AE
Case
Department of Chemistry, University of California, Davis, One Shields Ave, Davis, CA 95616, USA. Electronic address: satsumi@ucdavis.edu.
Shota
S
Atsumi
D000438:Alcohols / Q000378:metabolism; D056804:Biofuels; D050260:Carbohydrate Metabolism; D002264:Carboxylic Acids / Q000378:metabolism; D000458:Cyanobacteria / Q000378:metabolism*; D006838:Hydrocarbons / Q000378:metabolism; D060847:Metabolic Engineering
D000438:Alcohols; D056804:Biofuels; D002264:Carboxylic Acids; D006838:Hydrocarbons