Vitamin D receptor gene polymorphisms and lumbar disc degeneration: a systematic review and meta-analysis.
To examine the association between Vitamin D receptor (VDR) gene polymorphisms and lumbar disc degeneration (LDD) predisposition.



A comprehensive literature search was conducted to identify all the relevant studies. The allele/genotype frequencies were extracted from each study. We calculated the pooled odds ratios (ORs) and 95 % confidence intervals (CI) to assess the strength of the association between the VDR gene polymorphisms and LDD risk. Statistical analysis was performed using RevMan 5.31 software.



A total of 23 case-control studies (1835 cases and 1923 controls) were included in this systematic review. For the TaqI (rs731236), FokI (rs2228570) and ApaI (rs7975232) polymorphisms of VDR gene, nine studies, seven studies, and five studies, were eventually included in the meta-analysis, respectively. There was no evidence that the VDR gene polymorphisms (TaqI, FokI, ApaI) had significant associations with LDD risk.(for TaqI allelic comparison, OR = 1.07, 95 % CI 0.81-1.40, p = 0.64; for FokI allelic comparison, OR = 1.23, 95 % CI 0.83-1.82, p = 0.31; for ApaI allelic comparison, OR = 0.79, 95 % CI 0.55-1.14, p = 0.20). For stratified analyses by ethnicity and study design, no significant associations were found in Caucasian population and Asian population, as well as the population-based studies and hospital-based studies under all genetic models.



TaqI, FokI, and ApaI polymorphisms of VDR gene were not significantly associated with the predisposition of LDD. Large-scale and well-designed international studies are needed to further analyze this field.
Division of Spine Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Hua
H
Jiang
Division of Spine Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Zhilin
Z
Qin
Division of Spine Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Shaohui
S
Zong
Division of Spine Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Maolin
M
He
Division of Spine Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Xinli
X
Zhan
Division of Spine Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Zengming
Z
Xiao
Department of Orthopaedic Surgery, The First Affiliated Hospital of Guangxi Medical University, Shuangyong Road No. 6, Nanning, 530021, China. gxspine@163.com.
Qingjun
Q
Wei
D020022:Genetic Predisposition to Disease; D006801:Humans; D055959:Intervertebral Disc Degeneration / Q000235:genetics*; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*
D018167:Receptors, Calcitriol; C579457:VDR protein, human
Lumbar disc degeneration; Meta-analysis; Polymorphisms; Systematic review; Vitamin D receptor