The Activation Effects of Low Level Isopropyl Alcohol Exposure on Arterial Blood Pressures Are Associated with Decreased 5-Hydroxyindole Acetic Acid in Urine.
OBJECTIVE
The objectives of this paper are to study the impact of low level isopropyl alcohol exposure on blood pressure and to explore its potential mechanism.


METHODS
This cross-sectional study was based on a prospective occupational cohort in south China, which focusing on occupational risk factors related cardiovascular health problems. A total of 283 participants (200 low isopropyl alcohol exposed workers and 83 controls) was finally enrolled in this study. Linear regression models were used to analyze the relationship between arterial blood pressures and low level isopropyl alcohol exposure. We used mediation method to explore possible mediated roles of neurogenic factors.


RESULTS
Systolic blood pressure (SBP, 123±10 vs. 118±11), diastolic blood pressure (DBP, 79±7 vs. 74±7) and mean blood pressure (MBP, 93±8 vs. 89±9) were different between the exposed group and the control group (p < 0.01). After adjusting for covariates, the difference was still significant. Besides, isopropyl alcohol and smoking had an interactive effect on DBP and MBP (p < 0.05). Furthermore, we observed a mediated effect of 5-hydroxyindole acetic acid (5-HIAA) on isopropyl alcohol exposure induced arterial blood pressure increase, which accounted for about 25%.


CONCLUSIONS
Our results suggest that low level isopropyl alcohol exposure is a potential risk factor for the increased arterial blood pressure and 5-HIAA partly mediates the association between low level isopropyl alcohol exposure and arterial blood pressures.
Guangzhou Key Laboratory of Environmental Pollution and Risk Assessment, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.
Zhiqiang
Z
Zhao
Prevention and Control Center for Occupational Diseases, Zhongshan Center for Disease Control and Prevention, Zhongshan, Guangdong, China.
Xinxia
X
Liu
Guangzhou Key Laboratory of Environmental Pollution and Risk Assessment, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.
Xiumei
X
Xing
Guangzhou Key Laboratory of Environmental Pollution and Risk Assessment, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.
Yao
Y
Lu
Guangzhou Key Laboratory of Environmental Pollution and Risk Assessment, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.
Yi
Y
Sun
Guangzhou Key Laboratory of Environmental Pollution and Risk Assessment, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.
Xiaoyan
X
Ou
Guangzhou Key Laboratory of Environmental Pollution and Risk Assessment, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.
Xiaolin
X
Su
Guangzhou Key Laboratory of Environmental Pollution and Risk Assessment, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.
Jun
J
Jiang
Guangzhou Key Laboratory of Environmental Pollution and Risk Assessment, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.
Yarui
Y
Yang
Guangzhou Key Laboratory of Environmental Pollution and Risk Assessment, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.
Jingli
J
Chen
Guangzhou Key Laboratory of Environmental Pollution and Risk Assessment, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.
Biling
B
Shen
Guangzhou Key Laboratory of Environmental Pollution and Risk Assessment, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.
Yun
Y
He
D019840:2-Propanol / Q000008:administration & dosage / Q000009:adverse effects* / Q000032:analysis; D000293:Adolescent; D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects*; D002681:China; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine*; D006973:Hypertension / Q000139:chemically induced* / Q000652:urine; D008297:Male; D016273:Occupational Exposure; D011446:Prospective Studies; D012307:Risk Factors; D055815:Young Adult
D000395:Air Pollutants, Occupational; D006897:Hydroxyindoleacetic Acid; D019840:2-Propanol