Role of Systems Biology in Brain Injury Biomarker Discovery: Neuroproteomics Application.
Years of research in the field of neurotrauma have led to the concept of applying systems biology as a tool for biomarker discovery in traumatic brain injury (TBI). Biomarkers may lead to understanding mechanisms of injury and recovery in TBI and can be potential targets for wound healing, recovery, and increased survival with enhanced quality of life. The literature available on neurotrauma studies from both animal and clinical studies has provided rich insight on the molecular pathways and complex networks of TBI, elucidating the proteomics of this disease for the discovery of biomarkers. With such a plethora of information available, the data from the studies require databases with tools to analyze and infer new patterns and associations. The role of different systems biology tools and their use in biomarker discovery in TBI are discussed in this chapter.
Department of Biochemistry, Graduate School and University Center of CUNY, 365 Fifth Avenue, New York, NY, 10016, USA. zjaber@gradcenter.cuny.edu.|Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon. zjaber@gradcenter.cuny.edu.
Zaynab
Z
Jaber
Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon.
Patrick
P
Aouad
Division of Vascular Endothelium and Microcirculation, Department of Medicine III, University Hospital Carl Gustav Carus, TU Dresden, Fetscherstr. 74, 01307, Dresden, Germany.
Mohamad
M
Al Medawar
Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.|Faculty of Medicine, Beirut Arab University, Beirut, Lebanon.
Hisham
H
Bahmad
Faculty of Medicine, Beirut Arab University, Beirut, Lebanon.|Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Hussein
H
Abou-Abbass
Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Hiba
H
Ghandour
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy.
Stefania
S
Mondello
Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon. firasko@gmail.com.|Department of Psychiatry, Center for Neuroproteomics and Biomarkers Research, University of Florida, 4000 SW 23rd St., Apt. 5-204, Gainesville, FL, 32608, USA. firasko@gmail.com.|Banyan Biomarkers, Inc, Alachua, FL, USA. firasko@gmail.com.
Firas
F
Kobeissy
D000818:Animals; D015415:Biomarkers; D001930:Brain Injuries / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D020543:Proteome; D040901:Proteomics / Q000379:methods; D049490:Systems Biology / Q000379:methods
D015415:Biomarkers; D020543:Proteome
Biomarkers; GFAP; NSE; Neurotrauma; S100β; SBDPs; Systems biology tools; Traumatic brain injury TBI; UCHL1