Biotechnological Management of Skin Burn Injuries: Challenges and Perspectives in Wound Healing and Sensory Recovery.
Many wound management protocols have been developed to improve wound healing after burn with the primordial aim to restore the barrier function of the skin and also provide a better esthetic outcome. Autologous skin grafts remain the gold standard in the treatment of skin burn, but this treatment has its limitation especially for patients presenting limited donor sites due to extensive burn areas. Deep burn injuries also alter the integrity of skin-sensitive innervation and have an impact on patient's quality of life by compromising perceptions of touch, temperature, and pain. Thus, patients can suffer from long-term disabilities ranging from cutaneous sensibility loss to chronic pain. The cellular mechanisms involved in skin reinnervation following injury are not elucidated yet. Depending on the depth of the burn, nerve sprouting can occur from the wound bed or the surrounding healthy tissue, but somehow this process fails to provide correct reinnervation of the wound during scarring. In addition, several clinical observations indicate that damage to the peripheral nervous system influences wound healing, resulting in delayed wound healing or chronic wounds, underlining the role of innervation and neuromediators for normal cutaneous tissue repair development. Promising tissue engineering strategies, including the use of biomaterials, skin substitutes, and stem cells, could provide novel alternative treatments in wound healing and help in improving patient's sensory recovery.
1 University of Limoges , Myelin Maintenance and Peripheral Neuropathies (EA 6309), Faculties of Medicine and Pharmacy, Limoges, France .
Dorothée
D
Girard
1 University of Limoges , Myelin Maintenance and Peripheral Neuropathies (EA 6309), Faculties of Medicine and Pharmacy, Limoges, France .
Betty
B
Laverdet
2 University of Western Brittany , Laboratory of Neurosciences of Brest (EA 4685), Brest, France .
Virginie
V
Buhé
3 Paris Sud University , Unité mixte Inserm/SSA 1197, IRBA/CTSA/HIA Percy, École du Val de Grâce, Clamart, France .
Marina
M
Trouillas
4 Sorbonne University, Université de Technologie de Compiègne , CNRS UMR 7338 Biomechanics and Bioengineering, Centre de Recherche Royallieu, Compiègne, France .
Kamélia
K
Ghazi
3 Paris Sud University , Unité mixte Inserm/SSA 1197, IRBA/CTSA/HIA Percy, École du Val de Grâce, Clamart, France .
Maïa M
MM
Alexaline
4 Sorbonne University, Université de Technologie de Compiègne , CNRS UMR 7338 Biomechanics and Bioengineering, Centre de Recherche Royallieu, Compiègne, France .
Christophe
C
Egles
2 University of Western Brittany , Laboratory of Neurosciences of Brest (EA 4685), Brest, France .
Laurent
L
Misery
3 Paris Sud University , Unité mixte Inserm/SSA 1197, IRBA/CTSA/HIA Percy, École du Val de Grâce, Clamart, France .
Bernard
B
Coulomb
3 Paris Sud University , Unité mixte Inserm/SSA 1197, IRBA/CTSA/HIA Percy, École du Val de Grâce, Clamart, France .
Jean-Jacques
JJ
Lataillade
5 Centre LOEX de l'Université Laval, Centre de recherche du CHU de Québec and Département de Chirurgie, Faculté de Médecine, Université Laval , Québec, Canada .
François
F
Berthod
1 University of Limoges , Myelin Maintenance and Peripheral Neuropathies (EA 6309), Faculties of Medicine and Pharmacy, Limoges, France .
Alexis
A
Desmoulière
D002056:Burns; D006801:Humans; D011788:Quality of Life; D012867:Skin; D016038:Skin Transplantation; D014945:Wound Healing
burn injury; cutaneous wound healing; nerve fiber regrowth; skin engineering