Effects of mycoplasmal pneumonia of swine (MPS) lung lesion-selected Landrace pigs on MPS resistance and immune competence in three-way crossbred pigs.
To clarify the genetic influence of mycoplasmal pneumonia of swine (MPS) lesion-selected Landrace (La) on MPS resistance and immune characteristics in three-way crossbred pigs (LaWaDa), the LaWaDa pigs were compared with the non-selected crossbred (LbWbDb) and purebred (La) pigs. The MPS lesion score in the three lines was as follows: La line < LaWaDa line < LbWbDb line, with significant differences among the lines. The proportions of myeloid cells and T cells were lower and higher, respectively, in the LaWaDa pigs compared with those in the other two lines. Messenger RNA (mRNA) expression of interleukin (IL)-6, IL-10, transforming growth factor-β, and interferon-γ in peripheral blood was significantly increased after vaccination in the La and LaWaDa lines. IL-4 mRNA expression in the LaWaDa line was intermediate to the La and LbWbDb lines. Furthermore, principal component analysis for immune traits and MPS lesions was executed to clarify the characteristics of each pig line. These findings suggest that the immune responses in the three pig lines are genetically distinct and that MPS resistance and some immunity characteristics from the La line were transmitted to the three-way crossbred pigs.
Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
Liushiqi
L
Borjigin
Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
Tomoyuki
T
Shimazu
Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
Yuki
Y
Katayama
Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
Kouichi
K
Watanabe
Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
Haruki
H
Kitazawa
Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
Sang-Gun
SG
Roh
Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
Hisashi
H
Aso
Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
Kazuo
K
Katoh
Department of Food, Agriculture and Environment, Miyagi University, Sendai, Japan.
Masahiro
M
Satoh
Miyagi Prefecture Animal Industry Experiment Station, Iwadeyama, Miyagi, Japan.
Yoshihito
Y
Suda
Miyagi Prefecture Animal Industry Experiment Station, Iwadeyama, Miyagi, Japan.
Akiko
A
Sakuma
Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
Mituru
M
Nakajo
Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
Keiichi
K
Suzuki
D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology; D060467:Disease Resistance / Q000235:genetics* / Q000276:immunology*; D007113:Immunity, Innate / Q000235:genetics* / Q000276:immunology*; D007121:Immunocompetence / Q000235:genetics* / Q000276:immunology*; D007371:Interferon-gamma / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D009177:Mycoplasma pneumoniae / Q000276:immunology*; D045729:Pneumonia of Swine, Mycoplasmal / Q000235:genetics* / Q000276:immunology*; D000068618:Selective Breeding / Q000235:genetics*; D013552:Swine; D016212:Transforming Growth Factor beta / Q000097:blood
D001428:Bacterial Vaccines; D015850:Interleukin-6; D016212:Transforming Growth Factor beta; D016753:Interleukin-10; D007371:Interferon-gamma
disease resistance; immunogenic property; mycoplasma pneumonia lesion; three-way crossbred pig