Alpha-glucosidase inhibitors and hepatotoxicity in type 2 diabetes: a systematic review and meta-analysis.
Alpha-glucosidase inhibitors (AGIs) was reported to be associated with several rare adverse hepatic events, but with inconsistent results. We aimed to investigate the risk of hepatotoxicity associated with the use of AGIs in patients with type 2 diabetes mellitus (T2DM), and performed a systematic review and meta-analysis. Fourteen studies (n = 2881) were eligible, all of which were RCTs. Meta-analysis of data regarding elevation of more than 3-fold the upper limit of normal (ULN) of AST and ALT showed statistically significant differences between AGIs treatment versus control (OR 6.86, 95% CI 2.50 to 18.80; OR 6.48, 95% CI 2.40 to 17.49). Subgroup analyses of elevation of more than 1.8-fold ULN of AST and ALT by dose of AGIs showed differential effects on AST and ALT (AST: OR 0.38 vs 7.31, interaction P = 0.003; ALT: OR 0.32 vs 4.55, interaction p = 0.02). Meta-analysis showed that AGIs might increase the risk of hepatotoxicity, and higher dose appeared to be associated with higher risk of hepatotoxicity. However, the evidence is limited with surrogate measures (i.e. ALT and AST), and no clinically important adverse events were observed.
Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Longhao
L
Zhang
West China School of Public Health; Sichuan University, Chengdu 610041, China.
Qiyan
Q
Chen
Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Ling
L
Li
Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Joey S W
JS
Kwong
Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Pengli
P
Jia
Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Pujing
P
Zhao
Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Wen
W
Wang
Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Xu
X
Zhou
Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Mingming
M
Zhang
Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Xin
X
Sun
D000410:Alanine Transaminase / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000201:enzymology; D065089:Glycoside Hydrolase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use*; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008875:Middle Aged; D017594:Publication Bias
D065089:Glycoside Hydrolase Inhibitors; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase