Spinal dorsal horn astrocytes: New players in chronic itch.
Chronic itch is a debilitating symptom of inflammatory skin conditions, such as atopic dermatitis, and systemic diseases, for which existing treatment is largely ineffective. Recent studies have revealed the selective neuronal pathways that are involved in itch sensations; however, the mechanisms by which itch turns into a pathological chronic state are poorly understood. Recent advances in our understanding of the mechanisms producing chronic itch have been made by defining causal roles for astrocytes in the spinal dorsal horn in mouse models of chronic itch including atopic dermatitis. Understanding the key roles of astrocytes may provide us with exciting insights into the mechanisms for itch chronicity and lead to a previously unrecognized target for treating chronic itch.
Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan; Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: tsuda@phar.kyushu-u.ac.jp.
Makoto
M
Tsuda
D000818:Animals; D001253:Astrocytes / Q000378:metabolism / Q000473:pathology; D002908:Chronic Disease; D003876:Dermatitis, Atopic / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D051379:Mice; D011537:Pruritus / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D066148:Spinal Cord Dorsal Horn / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D009435:Synaptic Transmission
Astrocytes; Lipocalin-2; Mouse; STAT3; Spinal dorsal horn