Functionalization of Alkenes through Telescoped Continuous Flow Aziridination Processes.
Alkenes can be efficiently aziridinated using highly soluble iminoiodane derivatives under continuous flow conditions. By combining the aziridine generation with nucleophilic ring opening reactions, a variety of products can be made without the need to handle or isolate these potentially hazardous intermediates. Additionally, this chemistry can be used to make and use aziridines that are difficult to isolate and purify because of their high reactivity.
Department of Chemistry, University of Warwick , Gibbet Hill Road, Coventry, CV4 7AL, U.K.
Nathanael
N
Hsueh
Department of Chemistry, University of Warwick , Gibbet Hill Road, Coventry, CV4 7AL, U.K.
Guy J
GJ
Clarkson
Department of Chemistry, University of Warwick , Gibbet Hill Road, Coventry, CV4 7AL, U.K.
Michael
M
Shipman