Animal Stroke Model: Ischemia-Reperfusion and Intracerebral Hemorrhage.
Stroke is a major health issue worldwide-one with serious financial and public health implications. As a result, ongoing clinical research on novel and improved stroke therapies is not only pertinent but also paramount. Due to the complexity of a stroke-like event and its many sequelae, devising usable methods and experimental models are necessary to study and better understand the pathophysiological processes that ensue. As it stands, animal models that simulate stroke-like events have proven to be the most logical and effective options in regards to experimental studies. A number of animal stroke models exist and have been demonstrated in previous studies on ischemic as well as hemorrhagic stroke. Considering the efficiency and reproducibility of animal models, here, we introduce an ischemic stroke model induced by middle cerebral artery occlusion (MCAO) and an intracerebral hemorrhagic stroke model induced by collagenase injection. The models outlined here have been proven to demonstrate the clinical relevance desired for use in continued research on stroke pathophysiology and the study of future therapeutic options.
Institute of Hypoxia Medicine, Xuanwu Hospital, Capital Medical University, Chang Chun Road 45, Beijing, 100053, China.
Changhong
C
Ren
Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, USA.
Christopher
C
Sy
Institute of Hypoxia Medicine, Xuanwu Hospital, Capital Medical University, Chang Chun Road 45, Beijing, 100053, China.
Jinhuan
J
Gao
Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, USA.
Yuchuan
Y
Ding
Institute of Hypoxia Medicine, Xuanwu Hospital, Capital Medical University, Chang Chun Road 45, Beijing, 100053, China. jixm@ccmu.edu.cn.
Xunming
X
Ji
D000818:Animals; D001522:Behavior, Animal; D002543:Cerebral Hemorrhage / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D004195:Disease Models, Animal; D020244:Infarction, Middle Cerebral Artery / Q000150:complications / Q000601:surgery; D008297:Male; D051381:Rats; D015427:Reperfusion Injury / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology
Animal stroke model; Collagenase injection; Intracerebral hemorrhage; Intraluminal filament; Ischemia–reperfusion; Middle cerebral artery occlusion