Influence of total flavonoids derived from Choerospondias axillaris folium on aconitine-induced antiarrhythmic action and hemodynamics in Wistar rats.
It is well known that various traditional Chinese medicines produce antiarrhythmic actions. The aims of this study were to examine whether total flavones derived from Choerospondias axillaris folium (TFCF) also produced antiarrhythmic effects using a rat model of aconitine-induced arrhythmia and to compare these observations with the effects of total flavones of Choerospondias axillaris fructus (TFC). Wistar rats were orally administered TFC (0.2 g/kg) or TFCF (0.1, 0.2, or 0.4 g/kg) daily for 7 d. Subsequently, aconitine iv at 25 µg/kg was used to induce arrhythmia in these animals. Control (C) physiological saline and positive verapamil rats were also administered orally. The starting times of ventricular ectopic beats (VE), ventricular tachycardia (VT), ventricular fibrillation (VF), and heart arrest (HA) were recorded. In comparison to C, TFCF and TFC significantly prolonged the starting time of VE, VT, VF, and HA induced by aconitine. With respect to hemodynamics, TFC and high-dose TFCF were effective in reducing HR without associated changes in BP in all groups. TFC and TFCF decreased left ventricular systolic pressure (LVSP) and maximal velocity rate of ventricular pressure (+dp/dt max and -dp/dt min) with no marked effect on left ventricular end diastolic pressure (LVEDP) and -dp/dtmin. Data demonstrated that TFCF and TFC were equally effective in diminishing the aconitine-mediated arrhythmias. In addition, TFCF and TFC produced a similar reduction in HR with no accompanying change in BP. These findings indicate that the TFCF- and TFC-induced alterations may be attributed to inhibition of ventricular contraction without altering ventricular diastolic function.
a Department of Pharmacy , Baotou Medical College , Baotou , Inner Mongolia , China.
Min
M
Qiu
a Department of Pharmacy , Baotou Medical College , Baotou , Inner Mongolia , China.
Yong-He
YH
Dong
a Department of Pharmacy , Baotou Medical College , Baotou , Inner Mongolia , China.
Feng
F
Han
a Department of Pharmacy , Baotou Medical College , Baotou , Inner Mongolia , China.
Jian-Min
JM
Qin
a Department of Pharmacy , Baotou Medical College , Baotou , Inner Mongolia , China.
Hao-Nan
HN
Zhang
b College of Science , Guangdong Ocean University , Zhanjiang , Guangdong , China.
Jian-Xi
JX
Du
b College of Science , Guangdong Ocean University , Zhanjiang , Guangdong , China.
Xin-Min
XM
Hao
a Department of Pharmacy , Baotou Medical College , Baotou , Inner Mongolia , China.
Yu-Mei
YM
Yang
D000157:Aconitine / Q000633:toxicity; D027926:Anacardiaceae / Q000737:chemistry*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
D005419:Flavonoids; D010936:Plant Extracts; D000157:Aconitine