Responsive self-assembled nanostructured lipid systems for drug delivery and diagnostics.
While stimuli-responsive polymers have received a huge amount of attention in the literature, responsive lipid-based mesophase systems offer unique opportunities in biomedical applications such as drug delivery and biosensing. The different mesophase equilibrium structures enables dynamic switching between nanostructures to facilitate drug release or as a transducer for recognition events. In drug delivery, this behavior offers researchers the means to deliver a therapeutic payload at a specific rate and time i.e. 'on-demand'. This review summarizes the distinctive features of these multifaceted materials and aggregates the current state of the art research from our groups and others into the use of these materials as bulk gels and nanostructured dispersions for drug delivery, biosensing and diagnostics.
Food and Soft Materials Science, Department of Health Science and Technology, ETH Zurich, Schmelzbergstrasse 9, CH-8092 Zurich, Switzerland; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.
Wye-Khay
WK
Fong
Food and Soft Materials Science, Department of Health Science and Technology, ETH Zurich, Schmelzbergstrasse 9, CH-8092 Zurich, Switzerland.
Renata
R
Negrini
Food and Soft Materials Science, Department of Health Science and Technology, ETH Zurich, Schmelzbergstrasse 9, CH-8092 Zurich, Switzerland.
Jijo J
JJ
Vallooran
Food and Soft Materials Science, Department of Health Science and Technology, ETH Zurich, Schmelzbergstrasse 9, CH-8092 Zurich, Switzerland. Electronic address: raffaele.mezzenga@hest.ethz.ch.
Raffaele
R
Mezzenga
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia. Electronic address: ben.boyd@monash.edu.
Ben J
BJ
Boyd
D000818:Animals; D015374:Biosensing Techniques / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation; D055664:Electrochemical Techniques; D005782:Gels; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008027:Light; D008055:Lipids / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry* / Q000493:pharmacokinetics; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D055668:Photochemical Processes; D011108:Polymers / Q000737:chemistry* / Q000493:pharmacokinetics; D013696:Temperature
D005782:Gels; D008055:Lipids; D008081:Liposomes; D011108:Polymers
Biosensing; Drug delivery; Lipid; Lyotropic mesophase; Stimuli responsive