Computerized Tomography-Guided Stereotactic Biopsy of Intracranial Lesions: Report of 500 Consecutive Cases.
OBJECTIVE
Computed tomography (CT)-guided stereotactic brain biopsy has been performed in our clinic since March 1998. In this prospective study, we examined the patient data undergoing stereotactic biopsy and the results of biopsies in 500 consecutive patients.


METHODS
Between the dates of March 1998 and January 2015, CT-guided stereotactic biopsies were performed by using the Leksell stereotactic frame system (Elekta Instruments EU, Sweden) in 500 patients. A total of 512 procedures were performed in patients consisting of 184 females (36.8%) and 316 males (63.2%), ages ranging from 3 to 81 years (mean 50.40±16.67).


RESULTS
Conclusive histopathological diagnosis was not achieved in 17(3.3%) of 512 procedures. Of the others, 173 (33.8%) were high-grade gliomas, 103 (20.1%) were low-grade gliomas, 36 (7%) were malignant lymphomas, 34 (6.6%) were other types of brain tumors, 82 (16%) were metastasis and 67 (13.1%) were non-tumoral lesions. Complications were occurred in ten cases: 3 tumoral bleedings, 2 hypertensive cerebral hematomas, 2 peroperative convulsions, 1 epidural hematoma, 1 myocardial infarction and 1 brain edema. The patients who developed myocardial infarction and hypertensive thalamic hematoma died. The mortality was 0.4% and morbidity was 1.6% in 512 procedures.


CONCLUSIONS
CT-guided stereotactic biopsy is a reliable and a safe procedure in cases with intracranial lesions when histopathological diagnosis is required for the appropriate treatment.
Sisli Hamidiye Etfal Research and Training Hospital, Clinic of Neurosurgery, Istanbul, Turkey.
Songul Meltem
SM
Can
Osman Nuri
ON
Turkmenoglu
Canan
C
Tanik
Ender
E
Uysal
Baris
B
Ozoner
Saime Ayca
SA
Kaldirimoglu
Ahmet Murat
AM
Musluman
Adem
A
Yilmaz
Halit
H
Cavusoglu
Cicek
C
Bayindir
Yunus
Y
Aydin
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy / Q000379:methods; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D001927:Brain Diseases / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D001929:Brain Edema / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D005260:Female; D005910:Glioma / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D006407:Hematoma, Epidural, Cranial / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D020300:Intracranial Hemorrhages / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013238:Stereotaxic Techniques; D014057:Tomography, X-Ray Computed / Q000379:methods*; D055815:Young Adult