Voltammetric determination of 6-thioguanine and folic acid using a carbon paste electrode modified with ZnO-CuO nanoplates and modifier.
ZnO-CuO nanoplates and 2-chlorobenzoyl ferrocene, were synthesized and used to construct a modified carbon paste electrode. The electrooxidation of 6-thioguanine at the surface of the modified electrode was studied. Under the optimized conditions, the square wave voltammetric (SWV) peak current of 6-thioguanine increased linearly in the concentration range 0.05 to 200.0μM and detection limit of 25±2nM was obtained for 6-thioguanine. The prepared modified electrode exhibits a very good resolution between the voltammetric peaks of 6-thioguanine and folic acid which makes it suitable for the detection of 6-thioguanine in the presence of folic acid in real samples.
Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran. Electronic address: h.beitollahi@yahoo.com.
Hadi
H
Beitollahi
Department of Chemistry, Graduate University of Advanced Technology, Kerman, Iran.
Susan Ghofrani
SG
Ivari
Biotechnology Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran.
Masoud
M
Torkzadeh-Mahani
D002244:Carbon / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D055664:Electrochemical Techniques / Q000295:instrumentation; D004566:Electrodes; D005296:Ferrous Compounds / Q000737:chemistry; D005492:Folic Acid / Q000032:analysis* / Q000652:urine; D006801:Humans; D057230:Limit of Detection; D000075163:Metallocenes; D053761:Nanocomposites / Q000737:chemistry*; D010084:Oxidation-Reduction; D013866:Thioguanine / Q000032:analysis* / Q000652:urine; D015034:Zinc Oxide / Q000737:chemistry
D005296:Ferrous Compounds; D000075163:Metallocenes; D002244:Carbon; D003300:Copper; D005492:Folic Acid; D013866:Thioguanine; D015034:Zinc Oxide; C004998:ferrocene; C030973:cupric oxide
6-Thioguanine; Carbon paste electrode; Folic acid; Voltammetry; ZnO-CuO nanoplates