Medication use in people with late stage Parkinson's disease and parkinsonism living at home and in institutional care in north-east England: A balance of symptoms and side-effects?
People with Parkinson's disease (PD) and parkinsonism living in care homes (residential or nursing care) in the UK represent around 10-15% of all people with PD and 3-5% of all care home residents. There are few previous data on medication use in those living in care homes with PD. In this study we aimed to compare medication use in a representative cohort of people with PD living in care homes in north-east England with those living in their own homes.



All people with late stage (Hoehn and Yahr III-V) idiopathic PD, PD dementia, or atypical parkinsonian syndromes under the care of the Northumbria Healthcare NHS Foundation Trust PD service on 1st January 2015 were identified. Demographic, disease characteristics and medication use data were collected from an audit of medical notes of all those identified.



We identified 377 people who met the inclusion criteria, 91 (24.1%) of whom were living in a care home. Disease stage, age and age at disease onset were all significantly higher and levodopa equivalent dose significantly lower in those living in care homes, although disease duration and levodopa dose were not. Greater age, lower levodopa equivalent dose and higher disease stage were independently associated with being in a care home.



Although people in care homes had more advanced disease, they were on a significantly lower levodopa equivalent dose. This is likely to be due to the requirement to balance symptom management with drug side-effects.
Northumbria Healthcare NHS Foundation Trust, North Tyneside General Hospital, Rake Lane, North Shields, Tyne and Wear, UK. Electronic address: annette.hand@nhct.nhs.uk.
Annette
A
Hand
Northumbria Healthcare NHS Foundation Trust, North Tyneside General Hospital, Rake Lane, North Shields, Tyne and Wear, UK.
William K
WK
Gray
Northumbria Healthcare NHS Foundation Trust, North Tyneside General Hospital, Rake Lane, North Shields, Tyne and Wear, UK.
Lloyd L
LL
Oates
The Medical School, Newcastle University, Newcastle-upon-Tyne, UK.
Megan
M
Woolford
The Medical School, Newcastle University, Newcastle-upon-Tyne, UK.
Anna
A
Todd
The Medical School, Newcastle University, Newcastle-upon-Tyne, UK.
Elizabeth
E
Bale
Northumbria Healthcare NHS Foundation Trust, North Tyneside General Hospital, Rake Lane, North Shields, Tyne and Wear, UK.
Catherine
C
Jones
Northumbria Healthcare NHS Foundation Trust, North Tyneside General Hospital, Rake Lane, North Shields, Tyne and Wear, UK.
Brian H
BH
Wood
Northumbria Healthcare NHS Foundation Trust, North Tyneside General Hospital, Rake Lane, North Shields, Tyne and Wear, UK; Institute of Health and Society, Newcastle University, Newcastle-upon-Tyne, UK.
Richard W
RW
Walker
D000368:Aged; D000369:Aged, 80 and over; D000978:Antiparkinson Agents / Q000009:adverse effects; D004739:England; D005260:Female; D006699:Home Care Services / Q000706:statistics & numerical data*; D006801:Humans; D007980:Levodopa / Q000009:adverse effects; D008297:Male; D009735:Nursing Homes / Q000706:statistics & numerical data*; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy / Q000451:nursing; D020734:Parkinsonian Disorders / Q000150:complications / Q000188:drug therapy / Q000451:nursing; D004856:Postural Balance / Q000502:physiology*; D011788:Quality of Life; D012189:Retrospective Studies; D012678:Sensation Disorders / Q000209:etiology*
D000978:Antiparkinson Agents; D007980:Levodopa
Anti-parkinsonian medication; Care homes; Parkinson's disease