[Sarcoma developed in irradiated area: Preliminary results of the SARI trial].
Radiotherapy and surgery are the two main pillars of the locoregional treatment of cancer. The risk of second malignancy is better evaluated and constitutes a major issue regarding radioprotection of the patients. Among malignant disease observed in the surviving irradiated patients, the occurrence of sarcoma is a rare event but associated with a poor outcome since the 5 year overall survival is estimated at 10 to 35 %. The SARI protocol, written in 2011, included 120 patients and 240 controlled patients, irradiated in the same conditions but without sarcoma observed during the follow up. The main objective was to identify the clinical and biological factors associated with the occurrence of such a complication. The secondary objective was to identify the dosimetric characteristics of the treatment of the primary. Preliminary results will be presented during the 2016 meeting of the French radiation oncology society.
Département de radiothérapie, centre Georges-François-Leclerc, 1, rue du Pr-Marion, 21079 Dijon, France. Electronic address: pmaingon@cgfl.fr.
P
P
Maingon
Département de radiothérapie, centre Georges-François-Leclerc, 1, rue du Pr-Marion, 21079 Dijon, France.
C
C
Mirjolet
Service de radiothérapie, institut Gustave-Roussy, Inserm-UMR 1018 CESP, 114, rue Édouard-Vaillant, 94800 Villejuif, France.
I
I
Diallo
Service de radiothérapie, institut Gustave-Roussy, Inserm-UMR 1018 CESP, 114, rue Édouard-Vaillant, 94800 Villejuif, France.
C
C
Veres
Service d'anatomie-pathologique, centre Georges-François-Leclerc, 1, rue du Pr-Marion, 21079 Dijon, France.
F
F
Collin
Département d'oncologie médicale, institut Bergonié, 229, cours Argonne, 33000 Bordeaux, France.
A
A
Italiano
Inserm U916, 229, cours Argonne, 33000 Bordeaux, France.
F
F
Chibon
Institut de cancérologie de Lorraine, 6, avenue de Bourgogne, 54519 Vandœuvre-Lès-Nancy, France.
J L
JL
Merlin
Service d'anatomopathologie, institut Bergonié, 229, cours Argonne, 33000 Bordeaux, France.
J M
JM
Coindre
D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000628:therapy; D016609:Neoplasms, Second Primary / Q000473:pathology* / Q000628:therapy; D012509:Sarcoma / Q000473:pathology* / Q000628:therapy; D012983:Soft Tissue Neoplasms / Q000473:pathology* / Q000628:therapy
Cancérogénèse; Carcinogenesis; Complications tardives de la radiothérapie; Late toxicity; Radio-induced sarcoma; Radiotherapy; Radiothérapie; Sarcomes en territoire irradié