Angiopoietin-2, its soluble receptor Tie-2, and metabolic syndrome components in a population-based sample.
Since angiopoietin-2 (Ang-2) levels strongly correlate with cardiovascular mortality and subclinical cardiovascular disease, it was hypothesized that levels of Ang-2 and its soluble receptor (sTie-2) were associated with the metabolic syndrome (MetS) and individual MetS components.



Within the population-based Study of Health in Pomerania, two sets of analyses were performed. First, Ang-2 and sTie-2 were related to the prevalence of MetS and its components cross-sectionally (n = 3,205). Second, the association between baseline Ang-2 and sTie-2 and incident MetS or longitudinal changes in its components in 1,295 individuals was investigated.



High Ang-2 levels (90th percentile), compared with low Ang-2 levels (10th percentile), were positively associated with MetS (OR: 1.78) and with the following MetS criteria: increased triglycerides, lower HDL cholesterol, and higher non-fasting glucose. Furthermore, high sTie-2 levels (90th percentile), compared with low levels (10th percentile), were positively related to MetS (OR: 1.58) and most of its components. However, Ang-2 and sTie-2 levels were not associated with incident MetS or longitudinal change in components of MetS.



Ang-2 and sTie-2 levels were cross-sectionally associated with MetS and several of its components. However, Ang-2 and sTie-2 levels were not associated with incident MetS or changes in individual MetS components during follow-up.
Institute for Community Medicine, Section of Clinical Epidemiology, University Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany.|Institute of Clinical Radiology, Ludwig-Maximilian-University Hospital, Munich, Germany.
Roberto
R
Lorbeer
Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.
Sebastian E
SE
Baumeister
Department of Internal Medicine B, University Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany.|DZHK (German Centre for Cardiovascular Research), Partner Site, Greifswald, Germany.
Marcus
M
Dörr
DZHK (German Centre for Cardiovascular Research), Partner Site, Greifswald, Germany.|Institute of Clinical Chemistry and Laboratory Medicine, University Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany.
Matthias
M
Nauck
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany.
Anne
A
Grotevendt
Institute of Epidemiology, Christian Albrecht University, Kiel, Germany.
Sabrina
S
Schlesinger
Institute for Community Medicine, Section of Clinical Epidemiology, University Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany.
Alexander
A
Teumer
Institute for Community Medicine, Section of Clinical Epidemiology, University Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany.|DZHK (German Centre for Cardiovascular Research), Partner Site, Greifswald, Germany.
Henry
H
Völzke
Department of Psychiatry and Psychotherapy, University Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany.
Hans-Jörgen
HJ
Grabe
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany.
Henri
H
Wallaschofski
Preventive Medicine & Epidemiology Section, Boston University School of Medicine and Framingham Heart Study, Framingham, Massachusetts, USA.
Ramachandran S
RS
Vasan
Institute of Epidemiology, Christian Albrecht University, Kiel, Germany. wolfgang.lieb@epi.uni-kiel.de.
Wolfgang
W
Lieb
D000328:Adult; D042702:Angiopoietin-2 / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000378:metabolism*; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism*; D008875:Middle Aged; D015995:Prevalence; D042787:Receptor, TIE-2 / Q000097:blood*
D042702:Angiopoietin-2; D015415:Biomarkers; D042787:Receptor, TIE-2