Atypical immunoglobulin light chain amyloidosis: Spontaneous vertebral compression fracture, liver involvement, and bone marrow involvement report of 3 cases and review of the literature.
BACKGROUND
Primary immunoglobulin light chain amyloidosis (AL amyloidosis) is a plasma cell disorder which mainly affects heart, kidneys, liver, and peripheral nervous system. Cases of atypical AL amyloidosis presented as spontaneous vertebral compression fractures have been rarely reported, and data about the management and clinical outcomes of the patients are scarce.


METHODS
Herein, we present 3 new cases of AL amyloidosis with spontaneous vertebral compression fracture and review 13 cases retrieved from the literature.


RESULTS
Moreover, we observed overrepresentations of liver involvement and bone marrow involvement in AL amyloidosis with spontaneous vertebral compression fracture.


CONCLUSIONS
We believe that better awareness of the rare clinical presentation as spontaneous vertebral compression fracture of AL amyloidosis can facilitate earlier diagnosis and earlier treatment.
Department of Hematology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, PR China.
Xia
X
Wu
Jun
J
Feng
Xinxin
X
Cao
Lu
L
Zhang
Daobin
D
Zhou
Jian
J
Li
D000686:Amyloidosis / Q000150:complications* / Q000378:metabolism; D001855:Bone Marrow Diseases / Q000276:immunology; D005260:Female; D050815:Fractures, Compression / Q000276:immunology*; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000378:metabolism*; D008107:Liver Diseases / Q000276:immunology; D008297:Male; D008875:Middle Aged; D016103:Spinal Fractures / Q000276:immunology*
D007147:Immunoglobulin Light Chains