Cameo appearances of aminoacyl-tRNA in natural product biosynthesis.
The breadth of unprecedented enzymatic reactions performed during the formation of microbial natural products has continued to expand as new biosynthetic gene clusters are unearthed by genome mining. Enzymes that use aminoacyl-tRNA (aa-tRNA) outside of the translation machinery have been known for decades, and accounts of their use in natural product biosynthesis are just beginning to accumulate. This review will highlight the recent discoveries and advances in our mechanistic understanding of aa-tRNA-dependent enzymes that play key roles in the biosynthesis of a growing number of microbial natural products.
Department of Chemistry and the Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL 61801, USA; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1206 West Gregory Drive, Urbana, IL 61801, USA.
Emily C
EC
Ulrich
Department of Chemistry and the Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL 61801, USA; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1206 West Gregory Drive, Urbana, IL 61801, USA. Electronic address: vddonk@illinois.edu.
Wilfred A
WA
van der Donk
D000595:Amino Acid Sequence; D001665:Binding Sites; D001688:Biological Products / Q000378:metabolism*; D005810:Multigene Family; D012346:RNA, Transfer, Amino Acyl / Q000378:metabolism*
D001688:Biological Products; D012346:RNA, Transfer, Amino Acyl