What Is the Best Initial Empirical Treatment of Suspected Sepsis in a Newborn Readmitted Soon after Discharge Home in an Era of Increased Resistance to Antibiotics? A Report of Two Cases.
Background Colonization/infection by antibiotic-resistant bacteria is becoming a major threat to health care systems. Case report Two septic neonates were readmitted in our hospital few days after hospital discharge. In both of them, microbiological workup revealed an infection caused by multiresistant pathogens. Noteworthy, one baby had received intensive care management for 4 weeks, whereas the other had been vaginally delivered and sent home on his second day of life. Conclusion These cases suggest that in countries and/or hospital with high prevalence of colonization/infection by resistant pathogens in nurseries, neonatal intensive care units, and obstetric wards, the choice of initial therapy of suspected sepsis in a neonate readmitted from home soon after discharge should take into account the possibility of an infection due to a multiresistant pathogen.
Istituto Giannina Gaslini Children's Hospital, Genoa, Italy.
Elio
E
Castagnola
Ospedale Pediatrico Bambino Gesù, Rome, Italy.
Livia
L
Gargiullo
Istituto Giannina Gaslini Children's Hospital, Genoa, Italy.
Salvatore
S
Renna
Istituto Giannina Gaslini Children's Hospital, Genoa, Italy.
Anna
A
Loy
Istituto Giannina Gaslini Children's Hospital, Genoa, Italy.
Francesco
F
Risso
Istituto Giannina Gaslini Children's Hospital, Genoa, Italy.
Andrea
A
Moscatelli
Istituto Giannina Gaslini Children's Hospital, Genoa, Italy.
Ivana
I
Baldelli
Istituto Giannina Gaslini Children's Hospital, Genoa, Italy.
Giuliana
G
Cangemi
Istituto Giannina Gaslini Children's Hospital, Genoa, Italy.
Roberto
R
Bandettini
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003428:Cross Infection / Q000188:drug therapy*; D024881:Drug Resistance, Bacterial; D006801:Humans; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D007711:Klebsiella pneumoniae / Q000302:isolation & purification; D008297:Male; D010359:Patient Readmission; D018805:Sepsis / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000302:isolation & purification
D000900:Anti-Bacterial Agents