Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses.
Numerous studies suggested that oxidative stress (OS) played a central role in the onset and development of postmenopausal osteoporosis (PO); however, conflicting results were obtained as to the association of OS-related biomarkers and PO. This meta-analysis aimed to identify the association between these markers and PO, and explore factors that may explain the inconsistencies in these results. A systematic literature search was conducted in relevant database. Search terms and selection criteria were priorly determined to identify and include all studies that detected markers of OS in PO patients. We pooled data with a random effects meta-analysis with standardized mean differences and 95% confidence interval. Total 17 studies including 12 OS markers were adopted. The results showed that superoxide dismutase (SOD) in erythrocytes, catalase (CAT), total antioxidant status (TAS), hydroperoxides (HY), advanced oxidation protein products (AOPP), malondialdehyde (MDA), and vitamin B12 (VB12) in plasma/serum were not statistically different between the PO and control group, whereas significantly increased level of homocysteine (Hcy) and nitric oxide (NO), along with decreased SOD, glutathione peroxidase (GPx), folate, and total antioxidant power (TAP) in plasma/serum were obtained in the PO group. In summary, OS might serve as potential biomarkers in the etiopathophysiology and clinical course of PO.
Department of Prosthodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China.
Qiaozhen
Q
Zhou
Department of Prosthodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China.
Li
L
Zhu
Department of Prosthodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China.
Dafeng
D
Zhang
Department of Prosthodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China.
Ning
N
Li
Department of Pediatric Dentistry, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China.
Qiao
Q
Li
Department of Prosthodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China.
Panpan
P
Dai
Department of Prosthodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China.
Yixin
Y
Mao
Department of Prosthodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China.
Xumin
X
Li
Department of Prosthodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China.
Jianfeng
0000-0003-0395-0952
J
Ma
Department of Prosthodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China.
Shengbin
0000-0003-4522-2769
S
Huang
D015415:Biomarkers / Q000378:metabolism*; D005260:Female; D006801:Humans; D015663:Osteoporosis, Postmenopausal / Q000175:diagnosis* / Q000378:metabolism; D018384:Oxidative Stress
D015415:Biomarkers