Analysis on distribution features and drug resistance of clinically isolatedAcinetobacter baumannii.
The aim of the present study was to examine the clinical distribution and drug resistance ofAcinetobacter baumanniiinfection, and provide evidence of clinical medication as well as the prophylaxis for the treatment of drug resistance bacteria. In total, 306Acinetobacter baumanniisselected from routine culture were collected between January 2012 and December 2013, to analyze the distributions among clinical specimens and wards and their drug resistance state. Of the 306Acinetobacter baumanniis, the main distribution of specimens was sputum, accounting for 77.78%. The distribution of administrative office was dominated by intensive care unit with a proportion of 40.0% in 2012, which rapidly increased to 60.9% in 2013, followed by neurosurgery, respiration medicine and orthopedics with proportions of 23, 12 and 9.0% in 2012 and 9.71, 8.74 and 3.88% in 2013, respectively. TheAcinetobacter baumannii's drug resistance rate of Tazobactam and Piperacillin was increased from 68.0% in 2012 to 71.36% in 2013. At the same time, the drug resistance rate of imipenem was enhanced from 66.0% in 2012 to 72.81% in 2013. By 2013, the drug resistance rates of penbritin, ceftizoxime, cefotetan and macrodantin reached ≤100%. In conclusion,Acinetobacter baumanniimainly causes respiratory tract infection with severe drug resistance. The drug resistance ofAcinetobacter baumanniiwas mainly manifested as multidrug resistance or even pan-drug resistance with an obvious increasing trend of tolerance. Thus, it is necessary to prevent and treat nosocomial infection, to minimize usage of antibiotics and to standardize medical operating, to reduce the increase in persistence.
Department of Pneumology, The First People's Hospital of Xuzhou, Xuzhou, Jiangsu 221000, P.R. China.
Guangming
G
Ren
Department of Pneumology, The First People's Hospital of Xuzhou, Xuzhou, Jiangsu 221000, P.R. China.
Min
M
Zhou
Department of Pneumology, The First People's Hospital of Xuzhou, Xuzhou, Jiangsu 221000, P.R. China.
Ning
N
Ding
Department of Pneumology, The First People's Hospital of Xuzhou, Xuzhou, Jiangsu 221000, P.R. China.
Ning
N
Zhou
Department of Pneumology, The First People's Hospital of Xuzhou, Xuzhou, Jiangsu 221000, P.R. China.
Qingling
Q
Li
Acinetobacter baumanii; clinical distribution; drug resistance