The predictive value of arterial stiffness on major adverse cardiovascular events in individuals with mildly impaired renal function.
OBJECTIVE
Despite growing evidence that arterial stiffness has important predictive value for cardiovascular disease in patients with advanced stages of chronic kidney disease, the predictive significance of arterial stiffness in individuals with mildly impaired renal function has not been established. The aim of this study was to evaluate the predictive value of arterial stiffness on cardiovascular disease in this specific population.


METHODS
We analyzed measurements of arterial stiffness (carotid-femoral pulse-wave velocity [cf-PWV]) and the incidence of major adverse cardiovascular events (MACEs) in 1,499 subjects from a 4.8-year longitudinal study.


RESULTS
A multivariate Cox proportional-hazard regression analysis showed that in individuals with normal renal function (estimated glomerular filtration rate [eGFR] ≥90 mL/min/1.73 m(2)), the baseline cf-PWV was not associated with occurrence of MACEs (hazard ratio 1.398, 95% confidence interval 0.748-2.613; P=0.293). In individuals with mildly impaired renal function (eGFR <90 mL/min/1.73 m(2)), a higher baseline cf-PWV level was associated with a higher risk of MACEs (hazard ratio 2.334, 95% confidence interval 1.082-5.036; P=0.031).


CONCLUSIONS
Arterial stiffness is a moderate and independent predictive factor for MACEs in individuals with mildly impaired renal function (eGFR <90 mL/min/1.73 m(2)).
Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People's Republic of China.
Jie
J
Han
Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People's Republic of China.
Xiaona
X
Wang
Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People's Republic of China.
Ping
P
Ye
Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People's Republic of China.
Ruihua
R
Cao
Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People's Republic of China.
Xu
X
Yang
Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People's Republic of China.
Wenkai
W
Xiao
Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People's Republic of China.
Yun
Y
Zhang
Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People's Republic of China.
Yongyi
Y
Bai
Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People's Republic of China.
Hongmei
H
Wu
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D063177:Pulse Wave Analysis; D051437:Renal Insufficiency / Q000453:epidemiology*; D012307:Risk Factors; D059289:Vascular Stiffness
D015415:Biomarkers
MACEs; arterial stiffness; epidemiology; impaired renal function; predictive value