Prevalence of gestational diabetes mellitus according to IADPSG and NICE criteria.
OBJECTIVE
To investigate the impact of the International Association of Diabetic Pregnancy Study Group (IADPSG) diagnostic criteria on the prevalence of gestational diabetes mellitus (GDM) and overt diabetes as compared with the UK National Institute for Health and Care Excellence (NICE) criteria, and to evaluate the prevalence of maternal and perinatal outcomes among pregnant women with fasting plasma glucose (FPG) levels of 5.1-5.5 mmol/L.


METHODS
A retrospective study was undertaken of data for women who underwent a 2-hour 75-g oral glucose tolerance test at 24-32 weeks of a singleton pregnancy at a center in Croatia between January 2012 and December 2014.


RESULTS
Among 4646 included women, 1074 (23.1%) had GDM according to IADPSG criteria, 826 (17.8%) would be diagnosed according to NICE criteria, and 50 (1.1%) had overt diabetes. FPG levels were 5.1-5.5 mmol/L for 409 (8.8%) women. Compared with a control group (n=3391), these women had higher odds of large-for-gestational-age newborns (odds ratio 3.7, 95% CI 2.0-4.6) and cesarean delivery (odds ratio 1.8, 95% CI 1.3-2.3).


CONCLUSIONS
Women with FPG levels of 5.1-5.5 mmol/L have an increased risk of adverse maternal and perinatal outcome, although they would not be diagnosed with GDM according to NICE criteria.
School of Medicine, University of Zagreb, Zagreb, Croatia; Department of Obstetrics and Gynecology, Clinical Hospital Center, Zagreb, Croatia. Electronic address: josip.djelmis@zg.t-com.hr.
Josip
J
Djelmis
Department of Obstetrics and Gynecology, Clinical Hospital Center, Zagreb, Croatia.
Mato
M
Pavić
Department of Endocrinology, Pediatric Clinic, University Clinical Center, Prishtina, Republic of Kosovo.
Vjosa
V
Mulliqi Kotori
School of Medicine, University of Zagreb, Zagreb, Croatia; Department of Internal Medicine, Clinical Hospital Center, Zagreb, Croatia.
Ivana
I
Pavlić Renar
School of Medicine, University of Zagreb, Zagreb, Croatia; Department of Obstetrics and Gynecology, Clinical Hospital Center, Zagreb, Croatia.
Marina
M
Ivanisevic
School of Medicine, University of Zagreb, Zagreb, Croatia; Department of Obstetrics and Gynecology, Clinical Hospital Center, Zagreb, Croatia.
Slavko
S
Oreskovic
D000328:Adult; D002585:Cesarean Section; D017523:Croatia / Q000453:epidemiology; D036861:Delivery, Obstetric; D016640:Diabetes, Gestational / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D005320:Fetal Macrosomia / Q000453:epidemiology; D005951:Glucose Tolerance Test; D006801:Humans; D007231:Infant, Newborn; D016017:Odds Ratio; D011247:Pregnancy; D011256:Pregnancy Outcome; D015995:Prevalence; D012189:Retrospective Studies; D012955:Societies, Medical; D013222:State Medicine
Fetal morbidity; Gestational diabetes mellitus, IADPSG criteria; Maternal morbidity; NICE criteria