Color Me Infected: Painting Cellular Chromatin with a Viral Histone Mimic.
Viruses manipulate cellular chromatin to create a favourable milieu for infection. In several cases, virally-encoded proteins structurally mimic cellular histones to molecularly rewire the host cell. A recent study identified a novel mechanism whereby adenovirus protein VII, a viral histone, binds and manipulates host cell chromatin to suppress inflammatory signalling.
Department of Microbiology & Immunology, University of Western Ontario, London, Ontario, Canada.
Cason R
CR
King
Department of Microbiology & Immunology, University of Western Ontario, London, Ontario, Canada.
Tanner M
TM
Tessier
Department of Microbiology & Immunology, University of Western Ontario, London, Ontario, Canada; Departments of Oncology and Otolaryngology, University of Western Ontario, London, Ontario, Canada; London Regional Cancer Program and Lawson Health Research Institute, London, Ontario, Canada. Electronic address: jmymryk@uwo.ca.
Joe S
JS
Mymryk
D000260:Adenoviruses, Human / Q000502:physiology*; D002460:Cell Line; D002843:Chromatin / Q000378:metabolism*; D024243:HMGB1 Protein; D006657:Histones / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007249:Inflammation; D018716:Molecular Mimicry; D014764:Viral Proteins / Q000737:chemistry / Q000378:metabolism*; D014779:Virus Replication
D002843:Chromatin; D024243:HMGB1 Protein; D006657:Histones; D014764:Viral Proteins
HMGB1; adenovirus; chromatin; inflammation; protein VII; viral mimicry