Circular RNA: a new star in neurological diseases.
Circular RNAs (circRNAs) are novel endogenous non-coding RNAs characterized by the presence of a covalent bond linking the 3' and 5' ends generated by backsplicing. In this review, we summarize a number of the latest theories regarding the biogenesis, properties and functions of circRNAs. Specifically, we focus on the advancing characteristics and functions of circRNAs in the brain and neurological diseases. CircRNAs exhibit the characteristics of species conservation, abundance and tissue/developmental-stage-specific expression in the brain. We also describe the relationship between circRNAs and several neurological diseases and highlight their functions in neurological diseases.
a Department of Neurology, The First Affiliated Hospital of Zhengzhou University , Zhengzhou University , Zhengzhou , PR. China.|b Department of Neurology, Beijing Tiantan Hospital , Capital Medical University , Beijing , PR. China ; China National Clinical Research Center for Neurological Diseases , Beijing , PR. China.
Tao-Ran
TR
Li
a Department of Neurology, The First Affiliated Hospital of Zhengzhou University , Zhengzhou University , Zhengzhou , PR. China.
Yan-Jie
YJ
Jia
b Department of Neurology, Beijing Tiantan Hospital , Capital Medical University , Beijing , PR. China ; China National Clinical Research Center for Neurological Diseases , Beijing , PR. China.
Qun
Q
Wang
b Department of Neurology, Beijing Tiantan Hospital , Capital Medical University , Beijing , PR. China ; China National Clinical Research Center for Neurological Diseases , Beijing , PR. China.
Xiao-Qiu
XQ
Shao
b Department of Neurology, Beijing Tiantan Hospital , Capital Medical University , Beijing , PR. China ; China National Clinical Research Center for Neurological Diseases , Beijing , PR. China.
Rui-Juan
RJ
Lv
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D006801:Humans; D009422:Nervous System Diseases / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D012313:RNA / Q000096:biosynthesis* / Q000235:genetics*; D000079962:RNA, Circular
D000079962:RNA, Circular; D012313:RNA
circular RNAs; microRNA; microRNA sponge; neurological diseases; non-coding RNAs