Telomerase Activation in Hematological Malignancies.
Telomerase expression and telomere maintenance are critical for cell proliferation and survival, and they play important roles in development and cancer, including hematological malignancies. Transcriptional regulation of the rate-limiting subunit of human telomerase reverse transcriptase gen (hTERT) is a complex process, and unveiling the mechanisms behind its reactivation is an important step for the development of diagnostic and therapeutic applications. Here, we review the main mechanisms of telomerase activation and the associated hematologic malignancies.
Cutaneous Lymphoma Oncogenesis Team INSERM U1053 Bordeaux Research in Translational Oncology, Bordeaux University, Bordeaux 33076, France. joana.ropio@gmail.com.|Institute of Biomedical Sciences of Abel Salazar, University of Porto, Porto 4050-313, Portugal. joana.ropio@gmail.com.|Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto 4200-135, Portugal. joana.ropio@gmail.com.|Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup)-Cancer Biology, Rua Dr. Roberto Frias, s/n, Porto 4200-465, Portugal. joana.ropio@gmail.com.
Joana
J
Ropio
Cutaneous Lymphoma Oncogenesis Team INSERM U1053 Bordeaux Research in Translational Oncology, Bordeaux University, Bordeaux 33076, France. jp.merlio@u-bordeaux.fr.|Tumor Bank and Tumor Biology Laboratory, University Hospital Center Bordeaux, Pessac 33604, France. jp.merlio@u-bordeaux.fr.
Jean-Philippe
JP
Merlio
Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto 4200-135, Portugal. psoares@ipatimup.pt.|Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup)-Cancer Biology, Rua Dr. Roberto Frias, s/n, Porto 4200-465, Portugal. psoares@ipatimup.pt.|Department of Pathology and Oncology, Medical Faculty of Porto University, Porto 4200-319, Portugal. psoares@ipatimup.pt.
Paula
P
Soares
Cutaneous Lymphoma Oncogenesis Team INSERM U1053 Bordeaux Research in Translational Oncology, Bordeaux University, Bordeaux 33076, France. edith.chevret@u-bordeaux.fr.
Edith
E
Chevret
amplification; epigenetic; hematological malignancy; mutation; polymorphism; telomerase activity; virus