No association between FCGR2A and FCGR3A polymorphisms in Guillain-Barré Syndrome in a Brazilian population.
The pathogenesis of Guillain-Barré Syndrome (GBS) is not entirely understood, but includes infection-induced aberrant immune responses. Genetic polymorphisms in Fc gamma receptor genes (FCGR) have been associated with GBS. We assessed whether polymorphisms rs1801274 in FCGR2A and rs396991 in FCGR3A were associated with GBS in a Brazilian population. We genotyped 141 GBS cases and 364 healthy controls from Brazil for both polymorphisms. The FCGR genotypes and alleles frequencies did not differ significantly between GBS and controls. In addition, there was no genetic association with either severity or clinical outcomes. We conclude that these FCGR polymorphisms are not associated with susceptibility to Guillain-Barré Syndrome in this Brazilian population.
Department of Integrative Medicine, Federal University of Rio Grande do Norte, Natal, RN, Brazil; Health Post-Graduate Program, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Mario Emilio
ME
Dourado
Department of Biochemistry, Bioscience Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Leonardo Capistrano
LC
Ferreira
Department of Biochemistry, Bioscience Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil; Institute of Tropical Medicine of Rio Grande do Norte, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Francisco Paulo
FP
Freire-Neto
Health Post-Graduate Program, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil; Department of Biochemistry, Bioscience Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil; Institute of Tropical Medicine of Rio Grande do Norte, Federal University of Rio Grande do Norte, Natal, RN, Brazil; Institute of Science and Technology of Tropical Diseases, Salvador, BA, Brazil. Electronic address: smbj@cb.ufrn.br.
Selma M B
SM
Jeronimo
D000328:Adult; D000906:Antibodies / Q000097:blood; D001938:Brazil; D005260:Female; D005732:Gangliosides / Q000276:immunology; D056726:Genetic Association Studies; D005838:Genotype; D020275:Guillain-Barre Syndrome / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017452:Receptors, IgG / Q000235:genetics*; D012720:Severity of Illness Index
D000906:Antibodies; C445323:FCGR2A protein, human; C496124:FCGR3A protein, human; D005732:Gangliosides; D017452:Receptors, IgG
FCGR; Genetics; Guillain-Barré Syndrome; Polymorphism