The pol II CTD: new twists in the tail.
The C-terminal domain (CTD) of the large subunit of RNA polymerase (pol) II comprises conserved heptad repeats, and post-translational modification of the CTD regulates transcription and cotranscriptional RNA processing. Recently, the spatial patterns of modification of the CTD repeats have been investigated, and new functions of CTD modification have been revealed. In addition, there are new insights into the roles of the enzymes that decorate the CTD. We review these new findings and reassess the role of the pol II CTD in the regulation of gene expression.
Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
Justyna
J
Zaborowska
Laboratoire de Biologie Moléculaire Eucaryote, CNRS, Université Paul Sabatier, Toulouse, France.
Sylvain
S
Egloff
Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
Shona
S
Murphy
D000818:Animals; D016384:Consensus Sequence; D042863:Cyclin-Dependent Kinase 9 / Q000378:metabolism; D004257:DNA Polymerase II / Q000737:chemistry* / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D010766:Phosphorylation; D000072417:Protein Domains; D011499:Protein Processing, Post-Translational; D021122:Protein Subunits / Q000737:chemistry / Q000378:metabolism; D014158:Transcription, Genetic
D021122:Protein Subunits; D042863:Cyclin-Dependent Kinase 9; D004257:DNA Polymerase II