Predictive Factor of Surgical Efficacy in Male Patients with Prolactinoma.
Objective To analyze the predictive factor of surgical efficacy in male patients with prolactinoma. Method The clinical data of 184 male patients with prolactinoma who had undergone surgery were retrospectively analyzed.Results Before the surgery,the serum prolactin level from 150 to 204 952 ng/ml,the tumors sized 6 to 70 mm. Macroadenoma was seen in 152 cases (82.6%) and suprasellar adenoma with visual deficitsin 75 cases (40.7%). Complete resection was achieved in 149 patients. After surgical therapy,postoperative immediate prolactin level declined in 182 patients (98.4%);57 patients (31.0%)achieved initial remission,while the disease recurred in 26 patients (45.6%).Larger tumor had significantly lower rate of complete resection (P<0.05). The recurrence rate was significantly higher in the group with higher Ki-67 index (P<0.001). The recurrence rate was significantly lower in patients with intrasellar adenoma (P<0.001).No significant relationship was found between preoperative prolactin level and complete resection (P=0.306). Conclusions Tumor size can predictthe degree of surgical resection. The prognostic factors include tumor size,preoperative growth pattern of prolactinoma,and Ki-67 index.
Department of Neurosurgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
Mei-Ting
MT
Chen
Department of Neurosurgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
Wei
W
Lian
Department of Neurosurgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
Bing
B
Xing
Department of Neurosurgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
Yong
Y
Yao
Department of Neurosurgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
Ming
M
Feng
Department of Neurosurgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
Ren-Zhi
RZ
Wang
D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local; D010911:Pituitary Neoplasms / Q000473:pathology / Q000601:surgery*; D011184:Postoperative Period; D011388:Prolactin / Q000097:blood; D015175:Prolactinoma / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies
D011388:Prolactin