Incidental unilateral and bilateral ductal carcinoma in situ encountered in the surgical management of young male gynecomastia.
BACKGROUND
The increased risk for malignant tumors associated with male gynecomastia has been well established and many authors have reported cases of concurrent gynecomastia and ductal carcinoma in situ (DCIS) in the same breast. Synchronous bilateral breast cancer in association with gynecomastia is exceptionally rare. We aim to report and evaluate the management outcome of 5 cases of gynecomastia associated with DCIS (1 bilateral and 4 unilateral).


METHODS
A retrospective database analysis of the surgical treatment outcome of 74 male patients who had gynecomastia was done. A bilateral subcutaneous nipple-preserving mastectomy approach was done to all. Histopathology reports were reviewed.


RESULTS
74 patients diagnosed and treated for gynecomastia were included. The incidence rate of gynecomastia in our hospital male patients was 0.17%. The mean age was 22 years, range 17-29 years. Five (6.76%) patients were found in histopathology specimens to have DCIS, 1 patient (23 years old) had bilateral DCIS of low grade, 4 patients had unilateral positive involvement, 3 had right breast DCIS, and 1 had left breast DCIS, and all were of low-grade papillary subtype. The incidence of ductal carcinoma in situ among our series gynecomastia patients was 6.76%.


CONCLUSIONS
We conclude that gynecomastia is a benign breast disease but recent reports had described malignant variants, mostly DCIS, including 5 young males in our series. Therefore, regardless of the age group, histopathological examination of the resected gynecomastia tissue should be carefully done in all patients. Further evidence-based studies are needed to investigate the optimum management of incidental DCIS in gynecomastia specimens.
King Abdullah International Medical Research Center/King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.
Bader Hamza
BH
Shirah
Department of General Surgery, Al Ansar General Hospital, Medina, Saudi Arabia.
Hamza Assad
HA
Shirah
D000293:Adolescent; D000328:Adult; D018567:Breast Neoplasms, Male / Q000453:epidemiology* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000453:epidemiology* / Q000473:pathology; D006177:Gynecomastia / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D006801:Humans; D033162:Incidental Findings; D008297:Male; D012189:Retrospective Studies; D012529:Saudi Arabia / Q000453:epidemiology; D000069584:Unilateral Breast Neoplasms / Q000453:epidemiology* / Q000473:pathology; D055815:Young Adult
DCIS; Gynecomastia; breast hypertrophy; male; surgical treatment