Increased perceived stress is related to decreased prefrontal cortex volumes among older adults.
BACKGROUND
Several of the brain regions vulnerable to increased levels of stress (i.e., hippocampus and prefrontal cortex) are also known to undergo disproportionate decline during normal aging. To date, surprisingly little research has examined the effects of stress on the brain among healthy human populations, much less in the elderly. The aim of the current study was to investigate the relationship between chronic stress and brain morphometry in regions known for their involvement in the stress response, namely the prefrontal cortex, hippocampus, and amygdala, in a sample of healthy older adults.


METHODS
The Perceived Stress Scale and structural magnetic resonance imaging (MRI) were collected in 28 older adult individuals aged 65 to 90 years. Gray and white matter volumes in various regions of interest in the prefrontal cortex and medial temporal lobes were calculated using semiautomated segmentation tools.


RESULTS
Perceived stress was negatively correlated with overall prefrontal cortex (PFC) volume, specifically in overall white matter volume of the PFC. Additionally, perceived stress was negatively correlated with gray and white matter volumes in lateral regions of the PFC, specifically, in the ventrolateral and dorsolateral PFC. Perceived stress was not significantly related to medial temporal lobe volumes.


CONCLUSIONS
These findings suggest that among healthy older adults, there is a salient relationship between prefrontal cortex volumes and levels of perceived stress. This research fills a critical gap in the current literature and provides initial groundwork for future studies investigating the relationship between perceived stress and the prefrontal cortex in the context of healthy aging.
a Department of Psychology , New York University , New York , NY , USA.
Georgina L
GL
Moreno
b Department of Neurology , University of Iowa Carver College of Medicine , Iowa City , IA , USA.
Joel
J
Bruss
b Department of Neurology , University of Iowa Carver College of Medicine , Iowa City , IA , USA.
Natalie L
NL
Denburg
D000368:Aged; D000369:Aged, 80 and over; D001931:Brain Mapping; D005260:Female; D066128:Gray Matter / Q000000981:diagnostic imaging / Q000473:pathology*; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009929:Organ Size; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000473:pathology*; D013315:Stress, Psychological / Q000000981:diagnostic imaging / Q000473:pathology*; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000473:pathology; D066127:White Matter / Q000000981:diagnostic imaging / Q000473:pathology*
Aging; Brain; Chronic stress; Prefrontal cortex; Stress.