Fabrication a new modified electrochemical sensor based on Au-Pd bimetallic nanoparticle decorated graphene for citalopram determination.
This paper proposes a simple approach for sensing of citalopram (CTL) using gold-palladium bimetallic nanoparticles (Au-PdNPs) decorated graphene modified gold electrode. Au-PdNPs were deposited at the surface of a graphene modified gold electrode with simple electrodeposition method. The morphology and the electrochemical properties of the modified electrode were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), atomic force microscopy (AFM), energy dispersion spectroscopy (EDS), electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and square wave voltammetry (SWV). The novel sensor exhibited an excellent catalytic activity towards the oxidation of CTL. The oxidation peak current of CTL, was linear in the range of 0.5-50μM with a detection limit 0.049μM with respect to concentration of citalopram. The proposed sensor was successfully applied for determination of CTL tablet and human plasma samples with satisfactory results.
Department of Chemistry, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.
Leili
L
Daneshvar
Department of Chemistry, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran. Electronic address: ghrounaghi@yahoo.com.
Gholam Hossein
GH
Rounaghi
Department of Chemistry, Faculty of Sciences, Payame Noor University, Mashhad, Iran.
Zarrin
Z
Es'haghi
Department of Chemistry, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.
Mahmoud
M
Chamsaz
Department of Chemistry, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.
Somayeh
S
Tarahomi
D002138:Calibration; D015283:Citalopram / Q000032:analysis* / Q000097:blood / Q000737:chemistry; D004560:Electricity; D055664:Electrochemical Techniques / Q000379:methods*; D004566:Electrodes; D006046:Gold / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*
D015283:Citalopram; D010165:Palladium; D006046:Gold; D006108:Graphite
Citalopram; Gold–palladium bimetallic nanoparticle; Graphene; Modified electrode; Voltammetry