The contribution of the sympathetic nervous system to the immunopathology of experimental pulmonary tuberculosis.
The role of norepinephrine (NE) in the immunopathology of experimental tuberculosis (TB) was studied by measuring pulmonary NE and determining its cellular sources and targets. Functional studies were performed administrating adrenergic and anti-adrenergic drugs at different TB phases. Results showed high production of NE during early infection by adrenergic nerve terminals and lymphocytes located in the lungs and mediastinal lymph nodes, these cells highly expressed β2 adreno-receptors (β2AR) which by an autocrine mechanism promote Th-1 cell differentiation favoring protection. During advanced infection, the production of NE and β2AR sharply decreased, suggesting that adrenergic activity is less important during late TB.
Experimental Pathology Section, Pathology Department, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Vasco de Quiroga 15, Colonia Belisario Dominguez Seccion XVI, 14080, Deleg. Tlalpan, México City, Mexico. Electronic address: qcjbp77@yahoo.com.mx.
Jorge
J
Barrios-Payán
Experimental Pathology Section, Pathology Department, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Vasco de Quiroga 15, Colonia Belisario Dominguez Seccion XVI, 14080, Deleg. Tlalpan, México City, Mexico. Electronic address: betomedx@hotmail.com.
Alberto
A
Revuelta
Experimental Pathology Section, Pathology Department, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Vasco de Quiroga 15, Colonia Belisario Dominguez Seccion XVI, 14080, Deleg. Tlalpan, México City, Mexico. Electronic address: dulmat@yahoo.com.mx.
Dulce
D
Mata-Espinosa
Experimental Pathology Section, Pathology Department, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Vasco de Quiroga 15, Colonia Belisario Dominguez Seccion XVI, 14080, Deleg. Tlalpan, México City, Mexico. Electronic address: b_marquina@yahoo.com.
Brenda
B
Marquina-Castillo
Department of Psychoimmunology, National Institute of Psychiatry, "Ramón de la Fuente", Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Deleg. Tlalpan, 14370 México City, Mexico. Electronic address: lusenbeve@yahoo.com.
Enrique Becerril
EB
Villanueva
Department of Psychoimmunology, National Institute of Psychiatry, "Ramón de la Fuente", Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Deleg. Tlalpan, 14370 México City, Mexico. Electronic address: drosoph2001@yahoo.com.mx.
María Eugenia Hernández
ME
Gutiérrez
Department of Psychoimmunology, National Institute of Psychiatry, "Ramón de la Fuente", Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Deleg. Tlalpan, 14370 México City, Mexico. Electronic address: gipersanchez@hotmail.com.
Gilberto
G
Pérez-Sánchez
Department of Psychoimmunology, National Institute of Psychiatry, "Ramón de la Fuente", Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Deleg. Tlalpan, 14370 México City, Mexico. Electronic address: lkuriaki@imp.edu.mx.
Lenin
L
Pavón
Experimental Pathology Section, Pathology Department, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Vasco de Quiroga 15, Colonia Belisario Dominguez Seccion XVI, 14080, Deleg. Tlalpan, México City, Mexico. Electronic address: rhdezpando@hotmail.com.
Rogelio
R
Hernandez-Pando
D058666:Adrenergic beta-2 Receptor Agonists / Q000627:therapeutic use; D000818:Animals; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D000068759:Formoterol Fumarate / Q000627:therapeutic use; D008168:Lung / Q000378:metabolism / Q000473:pathology; D008214:Lymphocytes / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009169:Mycobacterium tuberculosis / Q000502:physiology; D009638:Norepinephrine / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D018343:Receptors, Adrenergic, beta-2 / Q000378:metabolism; D013234:Stem Cells; D013564:Sympathetic Nervous System / Q000502:physiology*; D013997:Time Factors; D014397:Tuberculosis, Pulmonary / Q000276:immunology* / Q000473:pathology* / Q000628:therapy*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D058666:Adrenergic beta-2 Receptor Agonists; D016207:Cytokines; D012333:RNA, Messenger; D018343:Receptors, Adrenergic, beta-2; D014446:Tyrosine 3-Monooxygenase; D000068759:Formoterol Fumarate; D009638:Norepinephrine
Norepinephrine; Sympathetic system; Tuberculosis; Tyrosine-hydroxylase; β-2 adrenoreceptor