Development of Co-based bulk metallic glasses as potential biomaterials.
A new series of Co80-x-yCrxMoyP14B6 (x=5 y=5; x=5 y=10; x=10 y=10, all values in at.%) bulk metallic glasses (BMGs) with a maximum diameter of 1.5mm has been developed for using them as potential bio-implant materials by a combination of fluxing treatment and J-quenching technique. The performance of the present Co-based BMGs in biomedical implant applications was investigated as compared to the CoCrMo biomedical alloy (ASTM F75) and 316L stainless steel (316L SS). The corrosion behavior of the samples was investigated in both Hank's solution (pH=7.4) and artificial saliva solution (pH=6.3) at 37°C employing electrochemical measurements. The results indicate that the Co-based BMGs exhibit much higher corrosion resistance in the simulated body solutions than that of 316L SS. Compared with the corrosion resistance of ASTM F75, that of Co70Cr5Mo5P14B6 and Co65Cr5Mo10P14B6 BMGs is found to be lower and that of Co60Cr10Mo10P14B6 BMG is higher. The concentrations of Co, Cr, and Mo ions released into the simulated body solutions from our Co-based BMGs after potentiodynamic polarization are significantly lower than that released from ASTM F75. The biocompatibility of the specimens was evaluated using an in vitro test of NIH3T3 cell culture in the specimen extraction media for 1, 3, 5, and 7days, revealing the non-cytotoxicity of the Co-based BMGs towards NIH3T3 cells. Moreover, examinations on the cell adhesion and growth on the surface of the specimens indicate that the Co-based BMGs exhibit better cell viability compared to ASTM F75 and 316L SS biomedical alloys.
School of Physics Science and Technology, Xinjiang University, Urumqi, Xinjiang 830046, People's Republic of China.
Zeyan
Z
Zhou
First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830046, People's Republic of China.
Qin
Q
Wei
School of Physics Science and Technology, Xinjiang University, Urumqi, Xinjiang 830046, People's Republic of China. Electronic address: qli@xju.edu.cn.
Qiang
Q
Li
First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830046, People's Republic of China. Electronic address: gaohan410@126.com.
Bingliang
B
Jiang
First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830046, People's Republic of China.
You
Y
Chen
School of Physics Science and Technology, Xinjiang University, Urumqi, Xinjiang 830046, People's Republic of China.
Yanfei
Y
Sun
D000497:Alloys / Q000737:chemistry; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000633:toxicity; D002448:Cell Adhesion / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002857:Chromium / Q000737:chemistry / Q000378:metabolism; D003035:Cobalt / Q000737:chemistry* / Q000378:metabolism; D003343:Corrosion; D055664:Electrochemical Techniques; D005898:Glass / Q000737:chemistry*; D007477:Ions / Q000737:chemistry / Q000378:metabolism; D007552:Isotonic Solutions / Q000737:chemistry; D051379:Mice; D008855:Microscopy, Electron, Scanning; D008982:Molybdenum / Q000737:chemistry / Q000378:metabolism; D041681:NIH 3T3 Cells; D012464:Saliva, Artificial / Q000737:chemistry; D013054:Spectrophotometry, Atomic; D013193:Stainless Steel / Q000737:chemistry
D000497:Alloys; D001672:Biocompatible Materials; C072670:Hanks Balanced Salt Solution; D007477:Ions; D007552:Isotonic Solutions; D012464:Saliva, Artificial; D002857:Chromium; D013193:Stainless Steel; D003035:Cobalt; D008982:Molybdenum
Biocompatibility; Biomaterials; Co-based bulk metallic glasses; Corrosion resistance