Coronary Plaque Characterization Assessed by Optical Coherence Tomography and Plasma Trimethylamine-N-oxide Levels in Patients With Coronary Artery Disease.
Optical coherence tomography (OCT) has been considered as the ideal tool for the evaluation of atherosclerotic plaques. Circulating trimethylamine-N-oxide (TMAO), which is a metabolite of the dietary lipid phosphatidylcholine, has recently been linked to elevated coronary artery disease (CAD) risk. The objective of the study was to investigate the relation between circulating TMAO level and coronary plaque vulnerability assessed by OCT in patients with CAD. A total of 26 patients with CAD were recruited to assess coronary plaque using OCT and measure plasma TMAO level. According to plaque rupture status, patients were divided into plaque rupture group (n = 12) and nonplaque rupture group (n = 14). Plasma TMAO level was significantly higher in patients with plaque rupture than in those with nonplaque rupture (8.6 ± 4.8 μmol/L vs 4.2 ± 2.4 μmol/L, p = 0.011). Moreover, positive correlations between plasma TMAO level and lipid arc (r = 0.43, p = 0.031), lipid volume index (r = 0.39, p = 0.048) were also observed. In conclusion, circulating TMAO level may reflect coronary plaque vulnerability and progression.
Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Qiang
Q
Fu
The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Peking University Health Science Center, Beijing, China.
Mingming
M
Zhao
Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Dezhao
D
Wang
Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Hongyu
H
Hu
Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Caixia
C
Guo
Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Wei
W
Chen
Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Qun
Q
Li
The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Peking University Health Science Center, Beijing, China. Electronic address: zhengl@bjmu.edu.cn.
Lemin
L
Zheng
Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address: chbux@126.com.
Buxing
B
Chen
D015415:Biomarkers / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008744:Methylamines / Q000097:blood*; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000097:blood* / Q000000981:diagnostic imaging*; D012307:Risk Factors; D041623:Tomography, Optical Coherence
D015415:Biomarkers; D008744:Methylamines; C005855:trimethyloxamine