Importance of sperm morphology during sperm transport and fertilization in mammals.
After natural or artificial insemination, the spermatozoon starts a journey from the site of deposition to the place of fertilization. However, only a small subset of the spermatozoa deposited achieves their goal: to reach and fertilize the egg. Factors involved in controlling sperm transport and fertilization include the female reproductive tract environment, cell-cell interactions, gene expression, and phenotypic sperm traits. Some of the significant determinants of fertilization are known (i.e., motility or DNA status), but many sperm traits are still indecipherable. One example is the influence of sperm dimensions and shape upon transport within the female genital tract towards the oocyte. Biophysical associations between sperm size and motility may influence the progression of spermatozoa through the female reproductive tract, but uncertainties remain concerning how sperm morphology influences the fertilization process, and whether only the sperm dimensions per se are involved. Moreover, such explanations do not allow the possibility that the female tract is capable of distinguishing fertile spermatozoa on the basis of their morphology, as seems to be the case with biochemical, molecular, and genetic properties. This review focuses on the influence of sperm size and shape in evolution and their putative role in sperm transport and selection within the uterus and the ability to fertilize the oocyte.
Department of Physiology, Faculty of Veterinary Science, International Excellence Campus for Higher Education and Research "Campus Mare Nostrum", University of Murcia, Murcia 30100, Spain.|Institute for Biomedical Research of Murcia (IMIB-Arrixaca), Murcia, Spain.
Francisco A
FA
García-Vázquez
Department of Physiology, Faculty of Veterinary Science, International Excellence Campus for Higher Education and Research "Campus Mare Nostrum", University of Murcia, Murcia 30100, Spain.|Institute for Biomedical Research of Murcia (IMIB-Arrixaca), Murcia, Spain.
Joaquín
J
Gadea
Department of Physiology, Faculty of Veterinary Science, International Excellence Campus for Higher Education and Research "Campus Mare Nostrum", University of Murcia, Murcia 30100, Spain.|Institute for Biomedical Research of Murcia (IMIB-Arrixaca), Murcia, Spain.
Carmen
C
Matás
Department of Human Metabolism, Academic Unit of Reproductive and Developmental Medicine, Sheffield S10 2SF, UK.
William V
WV
Holt
D000818:Animals; D048430:Cell Shape / Q000502:physiology; D005260:Female; D005306:Fertilization / Q000502:physiology*; D006801:Humans; D008297:Male; D008322:Mammals; D013081:Sperm Motility / Q000502:physiology; D013082:Sperm Tail / Q000502:physiology; D013083:Sperm Transport / Q000502:physiology*; D013084:Sperm-Ovum Interactions / Q000502:physiology*; D013094:Spermatozoa / Q000166:cytology* / Q000502:physiology