Intraoperative Vein Graft Preservation: What Is the Solution?
Saphenous vein graft (SVG) disease and subsequent vein graft failure remain a major problem after coronary artery bypass graft operations. In an effort to mitigate loss of endothelial viability, the vein is stored, intraoperatively, in a preservation solution. However, human SVG samples demonstrate endothelial denudation and dysfunction after such storage, the severity of which varies, depending on the medium. The paucity of clinical data evaluating preservation solutions is illustrated by the absence of optimal procedural protocol. This review evaluates the potential efficacy of different storage solutions in preserving vein grafts, in relation to a mechanistic understanding of SVG pathophysiology.
Christ Church, University of Oxford, Oxford, United Kingdom. Electronic address: lavinia.woodward@chch.ox.ac.uk.
Lavinia C
LC
Woodward
Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Charalambos
C
Antoniades
Department of Cardiac Surgery, Oxford University Hospitals Trust, Oxford, United Kingdom.
David P
DP
Taggart
D017023:Coronary Angiography; D001026:Coronary Artery Bypass / Q000379:methods*; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000601:surgery*; D006083:Graft Occlusion, Vascular / Q000517:prevention & control*; D006801:Humans; D007432:Intraoperative Period; D009926:Organ Preservation / Q000379:methods*; D012501:Saphenous Vein / Q000637:transplantation*