Managing Hyperkalemia: Stepping Into a New Frontier.
Maintaining potassium balance in the body is essential for cellular function. Even a slight increase in normal serum potassium levels (3.5-5.0 mEq/L) can interfere with metabolism, electrical action potentials, and cellular processes. Hyperkalemia is commonly seen in patients with chronic kidney disease (CKD) and in patients on renin-angiotensin-aldosterone system (RAAS) inhibitors. Sodium polystyrene sulfonate (SPS), diuretics, and hemodialysis are currently available methods for removing potassium from the body; however, these options have their limitations. Patiromer (Veltassa) and sodium zirconium cyclosilicate are 2 new therapeutic options that can potentially lead a new frontier in the management of hyperkalemia. This article will review these novel treatments.
1 Arnold and Marie Schwartz College of Pharmacy and Health Sciences, LIU Pharmacy, Brooklyn, NY, USA.|2 Department of Veterans Affairs-Manhattan Campus, New York Harbor Healthcare System, New York, NY, USA.
Antony Q
AQ
Pham
1 Arnold and Marie Schwartz College of Pharmacy and Health Sciences, LIU Pharmacy, Brooklyn, NY, USA.
Jessica
J
Sexton
1 Arnold and Marie Schwartz College of Pharmacy and Health Sciences, LIU Pharmacy, Brooklyn, NY, USA.
Dexter
D
Wimer
1 Arnold and Marie Schwartz College of Pharmacy and Health Sciences, LIU Pharmacy, Brooklyn, NY, USA.
Isha
I
Rana
1 Arnold and Marie Schwartz College of Pharmacy and Health Sciences, LIU Pharmacy, Brooklyn, NY, USA.
Timothy
T
Nguyen
D000818:Animals; D019468:Disease Management; D006801:Humans; D006947:Hyperkalemia / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy*; D011108:Polymers / Q000494:pharmacology / Q000627:therapeutic use*; D011188:Potassium / Q000097:blood*; D016032:Randomized Controlled Trials as Topic / Q000379:methods; D017640:Silicates / Q000494:pharmacology / Q000627:therapeutic use*; D014882:Water-Electrolyte Balance / Q000187:drug effects / Q000502:physiology
D011108:Polymers; D017640:Silicates; C568789:patiromer; C000597310:sodium zirconium cyclosilicate; D011188:Potassium
electrolytes; hyperkalemia; patiromer; potassium; sodium zirconium cyclosilicate