Polymorphisms of ICAM-1 and IL-6 genes related to endometriosis in a sample of Brazilian women.
OBJECTIVE
This study investigated the possibility of K469E (rs5498) and G241R (rs1799969) polymorphisms, in ICAM-1 gene, and G634C (rs1800796), in IL-6 gene, being associated with the occurrence of endometriosis in a sample of Brazilian women.


METHODS
We genotyped 200 women (100 in control group and 100 in endometriosis group) by PCR-RFLP technique for G634C, K469E, and G241R polymorphisms.


RESULTS
No significant difference was observed in genotypic frequency between control and endometriosis groups for G634C and K469E polymorphisms (p = 0.61 and p = 0.22, respectively). In addition, no significant difference between stages I-II and III-IV of the disease was found for both SNPs (p = 0.63 and p = 0.24, respectively). All individuals were wild homozygotes for G241R polymorphism.


CONCLUSIONS
This study suggests that polymorphisms K469E, G241R, and G634C are not associated with increased susceptibility to endometriosis in Brazilian women.
Department of Legal Medicine, Ethics and Occupational Health, Medical School, University of São Paulo, Rua Teodoro Sampaio, nº 115, Cerqueira Cesar, CEP: 05405-000, São Paulo, SP, Brazil.
Nathalie Zamagni
NZ
Bessa
Department of Legal Medicine, Ethics and Occupational Health, Medical School, University of São Paulo, Rua Teodoro Sampaio, nº 115, Cerqueira Cesar, CEP: 05405-000, São Paulo, SP, Brazil.
Daniela de Oliveira
DO
Francisco
Department of Obstetrics and Gynecology, Clinics Hospital, Medical School, University of São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 155, 10th floor, Cerqueira Cesar, CEP: 05403-010, São Paulo, SP, Brazil.
Marina de Paula
MP
Andres
Jewish Teaching and Research Institute, Albert Einstein Hospital, Avenida Albert Einstein 627, Morumbi, CEP: 05652-900, Sao Paulo, SP, Brazil.
Bárbara Yasmim
BY
Gueuvoghlanian-Silva
Department of Obstetrics and Gynecology, Clinics Hospital, Medical School, University of São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 155, 10th floor, Cerqueira Cesar, CEP: 05403-010, São Paulo, SP, Brazil.|Jewish Teaching and Research Institute, Albert Einstein Hospital, Avenida Albert Einstein 627, Morumbi, CEP: 05652-900, Sao Paulo, SP, Brazil.
Sergio
S
Podgaec
Department of Legal Medicine, Ethics and Occupational Health, Medical School, University of São Paulo, Rua Teodoro Sampaio, nº 115, Cerqueira Cesar, CEP: 05405-000, São Paulo, SP, Brazil. cfridman@usp.br.
Cintia
http://orcid.org/0000-0003-2430-4888
C
Fridman
D000328:Adult; D001938:Brazil; D004715:Endometriosis / Q000235:genetics* / Q000473:pathology; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D015850:Interleukin-6 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
C508600:IL6 protein, human; D015850:Interleukin-6; D018799:Intercellular Adhesion Molecule-1
Brazilian population; Endometriosis; Intercellular adhesion molecule-1; Interleukin-6; Polymorphism