Nickel-Catalyzed Site-Selective C-H Bond Difluoroalkylation of 8-Aminoquinolines on the C5-Position.
A simple and efficient protocol for nickel-catalyzed regioselective C-H bond difluoroalkylation of 8-aminoquinoline scaffolds with functionalized difluoromethyl bromides was developed. The reaction has broad substrate scope and provides a facile and useful access to the corresponding C5-functionalized difluoromethylated quinolines in good to excellent yields.
Department of Chemistry, Huaibei Normal University , Huaibei, Anhui 235000, P. R. China.
Hao
H
Chen
Department of Chemistry, Huaibei Normal University , Huaibei, Anhui 235000, P. R. China.
Pinhua
P
Li
Department of Chemistry, Huaibei Normal University , Huaibei, Anhui 235000, P. R. China.
Min
M
Wang
Department of Chemistry, Huaibei Normal University , Huaibei, Anhui 235000, P. R. China.|State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry , Shanghai 200032, P. R. China.
Lei
L
Wang