Mergeomics: a web server for identifying pathological pathways, networks, and key regulators via multidimensional data integration.
Human diseases are commonly the result of multidimensional changes at molecular, cellular, and systemic levels. Recent advances in genomic technologies have enabled an outpour of omics datasets that capture these changes. However, separate analyses of these various data only provide fragmented understanding and do not capture the holistic view of disease mechanisms. To meet the urgent needs for tools that effectively integrate multiple types of omics data to derive biological insights, we have developed Mergeomics, a computational pipeline that integrates multidimensional disease association data with functional genomics and molecular networks to retrieve biological pathways, gene networks, and central regulators critical for disease development.



To make the Mergeomics pipeline available to a wider research community, we have implemented an online, user-friendly web server ( http://mergeomics.



idre.ucla.edu/ ). The web server features a modular implementation of the Mergeomics pipeline with detailed tutorials. Additionally, it provides curated genomic resources including tissue-specific expression quantitative trait loci, ENCODE functional annotations, biological pathways, and molecular networks, and offers interactive visualization of analytical results. Multiple computational tools including Marker Dependency Filtering (MDF), Marker Set Enrichment Analysis (MSEA), Meta-MSEA, and Weighted Key Driver Analysis (wKDA) can be used separately or in flexible combinations. User-defined summary-level genomic association datasets (e.g., genetic, transcriptomic, epigenomic) related to a particular disease or phenotype can be uploaded and computed real-time to yield biologically interpretable results, which can be viewed online and downloaded for later use.



Our Mergeomics web server offers researchers flexible and user-friendly tools to facilitate integration of multidimensional data into holistic views of disease mechanisms in the form of tissue-specific key regulators, biological pathways, and gene networks.
Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, 90095, USA.
Douglas
D
Arneson
Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, 90095, USA.
Anindya
A
Bhattacharya
Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, 90095, USA.
Le
L
Shu
South Australian Health and Medical Research Institute, Adelaide, Australia.|School of Biological Sciences, University of Adelaide, Adelaide, Australia.|Institute of Health Sciences, University of Oulu, Oulu, Finland.
Ville-Petteri
VP
Mäkinen
Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, 90095, USA. xyang123@ucla.edu.
Xia
X
Yang
D004198:Disease Susceptibility; D053263:Gene Regulatory Networks; D056726:Genetic Association Studies; D023281:Genomics / Q000379:methods*; D006801:Humans; D015398:Signal Transduction; D012984:Software; D014584:User-Computer Interface; D064878:Web Browser
Disease network; EWAS; GWAS; Key driver; Multidimensional data integration; Network meta-analysis; Omics integration; Pathway meta-analysis; TWAS; Web server