Sensitivity of breast MRI for ductal carcinoma in situ appearing as microcalcifications only on mammography.
OBJECTIVE
This study aims to investigate sensitivity of breast magnetic resonance imaging (MRI) for mammographic microcalcifications-only ductal carcinoma in situ (DCIS), based on its histopathology and mammographic extent of microcalcifications.


METHODS
Mammograms were reviewed to measure the extent of microcalcifications. Sensitivity of MRI was calculated in the overall study population and in groups differing for DCIS nuclear grade, microinvasivity, and microcalcifications' extent.


RESULTS
Overall sensitivity of MRI was 78.3% for dynamic contrast enhanced and 66.7% for diffusion-weighted imaging and did not vary with nuclear grade and microinvasivity, while it increased with larger extent of microcalcifications (ExpB=1.063-1.046, P=.037-.013).


CONCLUSIONS
Mammographic extent of microcalcifications positively affects sensitivity of breast MRI.
Catholic University of Sacred Heart, Policlinico A. Gemelli, Department of Radiology, 8, Largo Francesco Vito, 00168, Rome, Italy.
Pierluigi
P
Rinaldi
Catholic University of Sacred Heart, Policlinico A. Gemelli, Department of Radiology, 8, Largo Francesco Vito, 00168, Rome, Italy. Electronic address: chiara.buccheri@hotmail.com.
Chiara
C
Buccheri
Catholic University of Sacred Heart, Policlinico A. Gemelli, Department of Radiology, 8, Largo Francesco Vito, 00168, Rome, Italy.
Michela
M
Giuliani
Catholic University of Sacred Heart, Policlinico A. Gemelli, Department of Radiology, 8, Largo Francesco Vito, 00168, Rome, Italy.
Enida
E
Bufi
Catholic University of Sacred Heart, Policlinico A. Gemelli, Department of Radiology, 8, Largo Francesco Vito, 00168, Rome, Italy.
Maurizio
M
Romani
Catholic University of Sacred Heart, Policlinico A. Gemelli, Department of Radiology, 8, Largo Francesco Vito, 00168, Rome, Italy.
Federica
F
Patrolecco
Catholic University of Sacred Heart, Policlinico A. Gemelli, Department of Radiology, 8, Largo Francesco Vito, 00168, Rome, Italy.
Paolo
P
Belli
Catholic University of Sacred Heart, Policlinico A. Gemelli, Department of Radiology, 8, Largo Francesco Vito, 00168, Rome, Italy.
Lorenzo
L
Bonomo
D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D002114:Calcinosis / Q000000981:diagnostic imaging*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008327:Mammography; D008875:Middle Aged; D012680:Sensitivity and Specificity
DCE MRI; DWI MRI; Ductal carcinoma in situ (DCIS); Mammography; Microcalcifications