Alterations in Factors Involved in Differentiation and Barrier Function in the Epithelium in Oral and Genital Lichen Planus.
Lichen planus is a chronic recurrent inflammatory disease affecting both skin and mucosa, mainly in oral and/or genital regions. Keratinocytes go through a well-regulated process of proliferation and differentiation, alterations in which may result in defects in the protective epithelial barrier. Long-term barrier impairment might lead to chronic inflammation. In order to broaden our understanding of the differentiation process in mucosal lichen planus, we mapped the expression of 4 factors known to be involved in differentiation. Biopsies were collected from oral and genital lichen planus lesions and normal controls. Altered expression of all 4 factors in epithelium from lichen planus lesions was found, clearly indicating disturbed epithelial differentiation in lichen planus lesions.
Department of Odontology, Umeå University, SE-90185 Umeå, Sweden. karin.danielsson@odont.umu.se, karin.p.danielsson@umu.se.
Karin
K
Danielsson
Majid
M
Ebrahimi
Elisabet
E
Nylander
Ylva Britt
YB
Wahlin
Karin
K
Nylander
D048948:14-3-3 Proteins / Q000032:analysis / Q000235:genetics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D002352:Carrier Proteins / Q000032:analysis / Q000235:genetics; D016022:Case-Control Studies; D002454:Cell Differentiation; D003598:Cytoskeletal Proteins; D004848:Epithelium / Q000503:physiopathology*; D005095:Exoribonucleases / Q000032:analysis / Q000235:genetics; D005260:Female; D005831:Genital Diseases, Female / Q000473:pathology / Q000503:physiopathology*; D005832:Genital Diseases, Male / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D051796:Inhibitor of Differentiation Proteins / Q000032:analysis / Q000235:genetics; D047908:Intracellular Signaling Peptides and Proteins; D017676:Lichen Planus, Oral / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008565:Membrane Proteins / Q000032:analysis / Q000235:genetics; D008875:Middle Aged; D009061:Mouth Mucosa / Q000737:chemistry / Q000473:pathology / Q000503:physiopathology*; D009363:Neoplasm Proteins / Q000032:analysis / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D011956:Receptors, Cell Surface / Q000032:analysis / Q000235:genetics
D048948:14-3-3 Proteins; D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D003598:Cytoskeletal Proteins; D051796:Inhibitor of Differentiation Proteins; D047908:Intracellular Signaling Peptides and Proteins; C492711:KAZN protein, human; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; C097051:epithelial membrane protein-1; C075640:ID3 protein, human; D005095:Exoribonucleases; C413442:SFN protein, human