Oxygen therapy in COPD patients with isolated nocturnal hypoxemia; comparison of quality of life and sleep between bronchitis and emphysema phenotype: A prospective observational study.
BACKGROUND
COPD is a heterogeneous disease composed by two main phenotypes: bronchitis (COPDb) and emphysema (COPDe) with different clinical presentation, physiology, imaging, response to therapy and decline in lung function. The aim of this study is to evaluate whether nocturnal hypoxemic COPDb and COPDe have a different behaviour during sleep and the effect of nocturnal oxygen supplementation (nO2LT).


METHODS
75 COPDb and 120 COPDe were enrolled. All patients performed polysomnography, Pittsburgh and Maugeri Foundation Respiratory Failure questionnaire, and pulmonary function before and after six months of nO2LT.


RESULTS
At baseline, compared to COPDb, COPDe have decreased sleep efficiency (SE) (67.5±6% vs. 76.9±3% p<0.05) and higher arousals (A/I) (18.1±3 event/h vs. 8.7±1 event/h p<0.05). Oxygen desaturation index (ODI) was increased during REM (7.1±1 event/h vs. 2.3±0.5 event/h p<0.05). nO2LT in COPDe improves SE (77±4% vs. 67.5±6% p<0.05) and decreases A/I (9±5 event/h vs. 18.1±3 event/h p<0.05). ODI during REM (3.5±2 event/h vs. 7.1±1 p<0.05) decreases and quality of life (QoL) improves (MFR-28 total 56±22 vs 45±20 p<0.05), due to an improvement in cognitive abilities (45±30 vs 33±31 p<0.05) and daily activities (61±29 vs 53±21 p>0.05). In COPDb nO2LT reduces ST90 (15±6% vs. 43±8% p<0.05) less than in COPDe (15±6% vs. 8±4% p<0.05); improves A/I (10±2 event/h vs. 8.7±1 p<0.05) and there is no evidence of an improvement in QoL.


CONCLUSIONS
Six months of nO2LT improve quality of life in COPDe, not in COPDb. We found a difference in sleep quality between COPDe and COPDb.
Pulmonary Department, "Luigi Sacco" University Hospital, Milan, Italy. Electronic address: rizzi.maurizio@asst-fbf-sacco.it.
Maurizio
M
Rizzi
Pulmonary Department, "Luigi Sacco" University Hospital, Milan, Italy. Electronic address: airoldi.andrea@asst-fbf-sacco.it.
Andrea
A
Airoldi
Pulmonary Department, "Luigi Sacco" University Hospital, Milan, Italy. Electronic address: andrea.cristiano@unimi.it.
Andrea
A
Cristiano
Pulmonary Department, "Luigi Sacco" University Hospital, Milan, Italy. Electronic address: francesca.frassanito@unimi.it.
Francesca
F
Frassanito
Pulmonary Department, "Luigi Sacco" University Hospital, Milan, Italy. Electronic address: claudio.macaluso@unimi.it.
Claudio
C
Macaluso
Pulmonary Department, "Luigi Sacco" University Hospital, Milan, Italy. Electronic address: vanni.silvia@asst-fbf-sacco.it.
Silvia
S
Vanni
Pulmonary Department, "Luigi Sacco" University Hospital, Milan, Italy. Electronic address: legnani.delfino@asst-fbf-sacco.it.
Delfino
D
Legnani
D001991:Bronchitis / Q000628:therapy*; D004646:Emphysema / Q000628:therapy*; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000628:therapy*; D007558:Italy; D008297:Male; D008875:Middle Aged; D010092:Oximetry; D010102:Oxygen Inhalation Therapy; D010641:Phenotype; D017286:Polysomnography; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000145:classification / Q000503:physiopathology*; D011788:Quality of Life; D012890:Sleep
COPD; Nocturnal hypoxemia; OTLT; Quality of life; Sleep quality