Designing sugar mimetics: non-natural pyranosides as innovative chemical tools.
The importance of oligosaccharides in myriad biological processes is becoming increasingly clear. However, these carbohydrate-mediated processes are often challenging to dissect due to the often poor affinity, stability and selectivity of the oligosaccharides involved. To circumvent these issues, non-natural carbohydrates-carbohydrate mimics-are being designed as innovative tools to modify biomolecules of interest or to understand biological pathways using fluorescence microscopy, X-ray or nuclear magnetic resonance spectroscopy (NMR). This review focuses on key examples of recently developed non-natural sugars to answer specific biological needs.
Department of Chemistry, Indiana University, Bloomington, IN 47401, United States. Electronic address: rsaliba@iu.edu.
Regis C
RC
Saliba
Department of Chemistry, Indiana University, Bloomington, IN 47401, United States. Electronic address: npohl@indiana.edu.
Nicola Lb
NL
Pohl
D002236:Carbohydrate Conformation; D050260:Carbohydrate Metabolism; D006027:Glycosides / Q000737:chemistry; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D018716:Molecular Mimicry
D006027:Glycosides; D008024:Ligands