Effectiveness of acellular pertussis vaccination during childhood (<7 years of age) for preventing pertussis in household contacts 1-9 years old in Catalonia and Navarra (Spain).
Pertussis vaccination with 4-5 doses of acellular vaccines is recommended in Spain to all children at 2 months to 6 years of age. The effectiveness of the acellular pertussis vaccination was assessed in this study by comparing the incidence of secondary pertussis in vaccinated (4-5 doses) and unvaccinated or partially vaccinated (0-3 doses) household contacts 1-9 years old of confirmed cases of pertussis in Spain in 2012-13. Eighty-five percent of contacts had been vaccinated with 4-5 doses of acellular pertussis vaccines. During the 2-year study period, 64 cases of secondary pertussis were detected among 405 household contacts 1-9 years old: 47 among vaccinated and 17 among unvaccinated or partially vaccinated contacts. The effectiveness for preventing secondary pertussis, calculated as 1 minus the relative risk (RR) of secondary pertussis in vaccinated vs. unvaccinated/partially vaccinated contacts, was 50 % [95 % confidence interval (CI): 19-69 %, p < 0.01] when household contacts were vaccinated using DTaP, Tdap, hexavalent or heptavalent vaccines, and it was 51.3 % (95 % CI: 21-70 %, p < 0.01) when they were vaccinated using DTaP or TdaP vaccines. The effectiveness adjusted for age, sex, pertussis chemotherapy and type of household contact was 58.6 % (95 % CI: 17-79 %, p < 0.05) when contacts were vaccinated using available acellular vaccines, and it was 59.6 % (95 % CI: 18-80 %, p < 0.01) when they were vaccinated using DTaP vaccines. Acellular pertussis vaccination during childhood was effective for preventing secondary pertussis in household contacts 1-9 years old of pertussis cases in Catalonia and Navarra, Spain.
Department of Health of Catalonia, Public Health Agency of Catalonia, Roc Boronat 83-95, 008005, Barcelona, Spain. pedro.plans@gencat.cat.|CIBER of Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain. pedro.plans@gencat.cat.
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Plans
CIBER of Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.
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Toledo
Department of Health of Catalonia, Public Health Agency of Catalonia, Roc Boronat 83-95, 008005, Barcelona, Spain.
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Sala
Department of Health of Catalonia, Public Health Agency of Catalonia, Roc Boronat 83-95, 008005, Barcelona, Spain.
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Camps
Molecular Microbiology Department, University Hospital Sant Joan de Deu, Barcelona, Spain.
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Villanova
Department of Health of Catalonia, Public Health Agency of Catalonia, Roc Boronat 83-95, 008005, Barcelona, Spain.
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Rodríguez
Department of Health of Catalonia, Public Health Agency of Catalonia, Roc Boronat 83-95, 008005, Barcelona, Spain.
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Alvarez
Public Health Agency of Barcelona, Barcelona, Spain.
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Solano
CIBER of Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.|Institute of Public Health of Navarra, Pamplona, Spain.
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García-Cenoz
Department of Health of Catalonia, Public Health Agency of Catalonia, Roc Boronat 83-95, 008005, Barcelona, Spain.
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Barrabeig
Department of Health of Catalonia, Public Health Agency of Catalonia, Roc Boronat 83-95, 008005, Barcelona, Spain.|CIBER of Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.
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Godoy
Department of Health of Catalonia, Public Health Agency of Catalonia, Roc Boronat 83-95, 008005, Barcelona, Spain.
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Minguell
D002648:Child; D002675:Child, Preschool; D018562:Disease Transmission, Infectious / Q000517:prevention & control*; D005191:Family Characteristics; D005192:Family Health; D005260:Female; D006801:Humans; D007115:Immunization Schedule; D015994:Incidence; D007223:Infant; D008297:Male; D010567:Pertussis Vaccine / Q000008:administration & dosage* / Q000276:immunology; D013030:Spain / Q000453:epidemiology; D016896:Treatment Outcome; D022282:Vaccines, Acellular / Q000008:administration & dosage / Q000276:immunology; D014917:Whooping Cough / Q000453:epidemiology* / Q000517:prevention & control*
D010567:Pertussis Vaccine; D022282:Vaccines, Acellular