Porous magnesium loaded with gentamicin sulphate and in vitro release behavior.
Our aim was to develop a biocompatible bone repair material that has the advantage of preventing postoperative infections. Finally, the porous magnesium (p-Mg) loaded with gentamicin sulphate (GS-loaded Mg-G) was fabricated. The GS release behavior of the GS-loaded Mg-G in phosphate buffer saline (PBS) was investigated. The effective release time of GS reached to 14days. In addition, the effects of porosity and pore diameter of p-Mg on the GS release behavior of the GS-loaded Mg-G were studied. In the initial burst release stage, the GS release rate of the GS-loaded Mg-G increased with the increasing porosity or the increasing pore diameter of p-Mg. The GS-loaded Mg-G with larger original pore diameter has higher burst release of GS. Moreover, the in vitro antibacterial test of the GS-loaded Mg-G indicated that this biomaterial has obvious antibacterial effect. This study can provide information for p-Mg loaded with drug(s) as functional bone repair materials with drug-delivery capabilities.
Shanghai Key Laboratory of Materials Laser Processing and Modification and State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Qiuyan
Q
Li
Shanghai Key Laboratory of Materials Laser Processing and Modification and State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Guofeng
G
Jiang
Shanghai Key Laboratory of Materials Laser Processing and Modification and State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Dong
D
Wang
Shanghai Key Laboratory of Materials Laser Processing and Modification and State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Huang
H
Wang
Shanghai Oriental Maritime Engineering Technology Co., Ltd, China Ship Scientific Research Center, Shanghai 200011, China.
Liang
L
Ding
Shanghai Key Laboratory of Materials Laser Processing and Modification and State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China; Collaborative Innovation Center for Advanced Ship and Deep-Sea Exploration, Shanghai 200240, China. Electronic address: ghe@sjtu.edu.cn.
Guo
G
He
D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D005780:Gelatin / Q000737:chemistry; D005839:Gentamicins / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D008274:Magnesium / Q000737:chemistry*; D016062:Porosity; D013211:Staphylococcus aureus / Q000187:drug effects
D001672:Biocompatible Materials; D004337:Drug Carriers; D005839:Gentamicins; D005780:Gelatin; D008274:Magnesium
Bone repair; Drug release; Gelatin; Gentamicin; Magnesium