High dose Vitamin D intake and quality of life in relapsing-remitting multiple sclerosis: a randomized, double-blind, placebo-controlled clinical trial.
BACKGROUND
Low level of vitamin D is associated with a more severe course and low quality of life in relapsing-remitting multiple sclerosis (RRMS). Low dose vitamin D intake has improved quality of life in RRMS patients.


OBJECTIVE
This study explored the effect of high dose vitamin D intake on quality of life in RRMS patients in a double blind randomized clinical trial.


METHODS
94 RRMS patients were randomized to two groups. One group received 50,000 IU vitamin D3 every five days for 3 months. The other group received placebo. Interferon-β (IFN-β) continued as the main treatment in both groups. Quality of life was assessed using MSQOL-54 Persian version at the beginning and at the end of the study.


RESULTS
After 3 months, the vitamin D group had a significant difference in mental health composite with placebo group, 62.41 ± 13.99 vs. 60.99 ± 17.99 (p-value = 0.041). Change in health was 75.74 ± 25.73 and 70.59 ± 26.45 in vitamin D and placebo group, respectively (p-value = 0.036).


CONCLUSIONS
Mental QOL improved significantly after taking high dose vitamin D for 3 months in vitamin D group relative to placebo.
a Department of Neurology , Isfahan University of Medical sciences , Isfahan , Iran.
Fereshteh
F
Ashtari
b Isfahan Neuroscience Research Center , Isfahan University of Medical Sciences , Isfahan , Iran.
Nafiseh
N
Toghianifar
c Department of Biology , University Of Isfahan , Isfahan , Iran.
Sayyed Hamid
SH
Zarkesh-Esfahani
d Department of Biostatistics and Epidemiology, Health School , Isfahan University of Medical Sciences , Isfahan , Iran.
Marjan
M
Mansourian
D000293:Adolescent; D000328:Adult; D004185:Disability Evaluation; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D016899:Interferon-beta / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000523:psychology* / Q000628:therapy*; D011788:Quality of Life / Q000523:psychology*; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D014807:Vitamin D / Q000008:administration & dosage*; D014815:Vitamins / Q000008:administration & dosage*; D055815:Young Adult
D007155:Immunologic Factors; D014815:Vitamins; D014807:Vitamin D; D016899:Interferon-beta
Mental health; Multiple sclerosis; Physical health; Quality of life; Vitamin D