Present Yourself! By MHC Class I and MHC Class II Molecules.
Since the discovery of MHC molecules, it has taken 40 years to arrive at a coherent picture of how MHC class I and MHC class II molecules really work. This is a story of the proteases and MHC-like chaperones that support the MHC class I and II molecules in presenting peptides to the immune system. We now understand that the MHC system shapes both the repertoire of presented peptides and the subsequent T cell response, with important implications ranging from transplant rejection to tumor immunotherapies. Here we present an illustrated review of the ins and outs of MHC class I and MHC class II antigen presentation.
Department of Pathology, UMass Medical School, Worcester, MA, USA.
Kenneth L
KL
Rock
Department of Cell Biology and Histology, Amsterdam Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Eric
E
Reits
Department of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands; Department of Chemical Immunology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: J.J.C.Neefjes@lumc.nl.
Jacques
J
Neefjes
D000818:Animals; D017951:Antigen Presentation; D000941:Antigens / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology / Q000628:therapy*; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D000949:Histocompatibility Antigens Class II / Q000378:metabolism*; D006801:Humans; D007167:Immunotherapy / Q000379:methods* / Q000639:trends; D008213:Lymphocyte Activation; D018832:Molecular Chaperones / Q000378:metabolism; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D016377:Organ Transplantation; D010446:Peptide Fragments / Q000276:immunology; D010447:Peptide Hydrolases / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D018832:Molecular Chaperones; D010446:Peptide Fragments; D010447:Peptide Hydrolases
MHC class I; MHC class II; antigen presentation; autoimmune diseases; transplantation; tumor immunology