Two Cases of Endometrial Cancer in Twin Sisters with Myotonic Dystrophy.
We describe two cases of endometrial cancer (EC) occurring in nulligravid twin sisters with myotonic dystrophy. Both tested negative for Lynch syndrome and both were treated with laparoscopic hysterectomy with bilateral salpingooophorectomy and adjuvant radiotherapy. Although EC tends to run in families, the diagnosis in itself is not considered sufficient cause for screening or prophylactic measures in close relatives. However, the presence of additional risk factors, such as nulligravidity and myotonic dystrophy in the underlying cases, may call for extra vigilance in first-degree family members.
Department of Obstetrics & Gynecology, Onze Lieve Vrouwe Gasthuis, 1091 AC Amsterdam, Netherlands.
Ezra Y
0000-0002-0471-0574
EY
Koh
Department of Obstetrics & Gynecology, Onze Lieve Vrouwe Gasthuis, 1091 AC Amsterdam, Netherlands.
Paul J M
0000-0001-5111-3951
PJ
van Kesteren