The Relevance of Mammalian Peroxiredoxins to the Gametogenesis, Embryogenesis, and Pregnancy Outcomes.
Peroxiredoxin (PRX) defines a family that provides antioxidant defense in different cell types by removing reactive oxygen species (ROS) through conserved active cysteines, with the support of other types of antioxidants such as thioredoxin, glutaredoxin, and glutathione peroxidase. By regulation of intracellular ROS levels, the mammalian PRXs influence a variety of reproductive processes including gamete maturation, fertilization, and embryo development. Experimental mice lacking PRXs developed normally, but some showed accelerated decrease in fertility with aging, suggesting that deficiency of PRXs did not have lethal consequences for reproduction. The aim of this review is to summarize the role of mammalian PRXs in the reproductive performance.
1 Department of Reproductive Medicine, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China.
Lianqin
L
Li
D000818:Animals; D047108:Embryonic Development / Q000502:physiology*; D005260:Female; D005718:Gametogenesis / Q000502:physiology*; D006801:Humans; D008322:Mammals; D018384:Oxidative Stress / Q000502:physiology; D054464:Peroxiredoxins / Q000378:metabolism*; D011247:Pregnancy; D011256:Pregnancy Outcome; D017382:Reactive Oxygen Species / Q000378:metabolism
D017382:Reactive Oxygen Species; D054464:Peroxiredoxins
oxidative stress; peroxiredoxin; reproduction; spontaneous abortion