Skin compatibility and antimicrobial studies on biofunctionalized polypropylene fabric.
The aim of this study was the development of antimicrobial fabric which can be used as skin contacting material. The nanosilver loaded bioactive nanogels of polyacrylamide were prepared by gamma irradiation process and the particle size was observed to be in the range of 10-50nm. In this study, we used polyethylene glycol as carrier for the combination of functional nanogel and essential oils together. Plasma functionalized polypropylene fabric was used as the base material for the bio-immobilization. Bioactive emulsion was coated on the fabric which exhibited excellent antimicrobial activity against Staphylococcus aureus and Escherichia coli. Skin irritation studies were carried out over a period of 3d on Swiss albino mice. Histopathology studies of the fabric did not show adverse inflammatory response in contact with the skin. The biofunctionalized fabric offers appear to be promising material for skin contacting applications.
Bioengineering Laboratory, Department of Textile Technology, Indian Institute of Technology, New Delhi 110016, India.
Sadiya
S
Anjum
Department of Pathology, Sikkim Manipal Institute of Medical Sciences, Sikkim Manipal University, Gangtok 737102, India.
Amlan
A
Gupta
Department of Pathology, Sikkim Manipal Institute of Medical Sciences, Sikkim Manipal University, Gangtok 737102, India.
Deepika
D
Sharma
Bioengineering Laboratory, Department of Textile Technology, Indian Institute of Technology, New Delhi 110016, India.
Prashansa
P
Dalal
Bioengineering Laboratory, Department of Textile Technology, Indian Institute of Technology, New Delhi 110016, India. Electronic address: bgupta@textile.iitd.ernet.in.
Bhuvanesh
B
Gupta
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D015169:Colony Count, Microbial; D003432:Cross-Linking Reagents / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D000080385:Nanogels; D009822:Oils, Volatile / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000737:chemistry; D011094:Polyethyleneimine / Q000737:chemistry; D011126:Polypropylenes / Q000737:chemistry*; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013784:Textiles; D014961:X-Ray Diffraction
D000890:Anti-Infective Agents; D003432:Cross-Linking Reagents; D000080385:Nanogels; D009822:Oils, Volatile; D011126:Polypropylenes; C413692:polyethylene glycol polyethyleneimine nanogel; D011092:Polyethylene Glycols; D011094:Polyethyleneimine
Antimicrobial; Essential oil; Inflammation; Nanosilver nanogel; Polyacrylamide; Skin irritation