Maternal Forced Swimming Reduces Cell Proliferation in the Postnatal Dentate Gyrus of Mouse Offspring.
Physical exercise positively affects the metabolism and induces proliferation of precursor cells in the adult brain. Maternal exercise likewise provokes adaptations early in the offspring. Using a high-intensity swimming protocol that comprises forced swim training before and during pregnancy, we determined the effect of maternal swimming on the mouse offspring's neurogenesis. Our data demonstrate decreased proliferation in sublayers of the postnatal dentate gyrus in offspring of swimming mother at postnatal day (P) 8 accompanied with decreased survival of newly generated cells 4 weeks later. The reduction in cell numbers was predominantly seen in the hilus and molecular layer. At P35, the reduced amount of cells was also reflected by a decrease in the population of newly generated immature and mature neurons of the granule cell layer. Our data suggest that forced maternal swimming at high-intensity has a negative effect on the neurogenic niche development in postnatal offspring.
Max Delbrueck Center for Molecular Medicine, Molecular Biology of Hormones in the Cardiovascular SystemBerlin, Germany; Department of Biophysics, Federal University of São PauloSão Paulo, Brazil.
Frederick
F
Wasinski
Department of Biophysics, Federal University of São Paulo São Paulo, Brazil.
Gabriel R
GR
Estrela
Department of Biophysics, Federal University of São Paulo São Paulo, Brazil.
Aline M
AM
Arakaki
Max Delbrueck Center for Molecular Medicine, Molecular Biology of Hormones in the Cardiovascular SystemBerlin, Germany; Charité - University Medicine BerlinBerlin, Germany.
Michael
M
Bader
Max Delbrueck Center for Molecular Medicine, Molecular Biology of Hormones in the Cardiovascular System Berlin, Germany.
Natalia
N
Alenina
Max Delbrueck Center for Molecular Medicine, Molecular Biology of Hormones in the Cardiovascular System Berlin, Germany.
Friederike
F
Klempin
Department of Biophysics, Federal University of São Paulo São Paulo, Brazil.
Ronaldo C
RC
Araújo
BrdU; exercise; hippocampus; neurogenesis; pregnancy