Levels of vitamin D receptor and CYP24A1 in patients with end-stage renal disease.
OBJECTIVE
This study was performed to detect the expression of vitamin D receptor (VDR) and cytochrome P450, family 24, subfamily A, polypeptide 1 (CYP24A1) in 24 end stage renal disease (ESRD) patients and 24 healthy controls.


METHODS
In this study, 24 ESRD patients and 24 healthy controls were included.


RESULTS
In our study, the levels of VDR in patients with ESRD were reduced when compared with those from healthy controls (5.20±0.32 vs 8.59±1.03; P<0.01). However, the levels of CYP24A1 in ESRD patients were increased than those from healthy controls (50.18±21 vs 7.78±1.31; P<0.01). Correlation analysis showed that VDR levels were negatively correlated with CYP24A1 (r=-0.723; P<0.01).


CONCLUSIONS
VDR levels were reduced and CYP24A1 levels were increased in patients with ESRD, and VDR levels were negatively correlated with CYP24A1.
Department of Nephrology, Huadu District People's Hospital, Southern Medical University, Guangzhou 510800, China.
Jia-Jun
JJ
Ye
Department of Nephrology, the Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510655, China.
Tian-Biao
TB
Zhou
Department of Nephrology, Huadu District People's Hospital, Southern Medical University, Guangzhou 510800, China.
Yun-Fang
YF
Zhang
Department of Nephrology, Huadu District People's Hospital, Southern Medical University, Guangzhou 510800, China.
Qi
Q
Wang
Department of Nephrology, Huadu District People's Hospital, Southern Medical University, Guangzhou 510800, China.
Yan-Yan
YY
Su
Department of Nephrology, Huadu District People's Hospital, Southern Medical University, Guangzhou 510800, China.
Jia-Min
JM
Tang
Department of Nephrology, Huadu District People's Hospital, Southern Medical University, Guangzhou 510800, China.
Hong-Yan
HY
Li
D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002681:China; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018167:Receptors, Calcitriol / Q000032:analysis / Q000097:blood*; D012016:Reference Values; D006435:Renal Dialysis / Q000379:methods / Q000401:mortality; D016019:Survival Analysis; D065668:Vitamin D3 24-Hydroxylase / Q000032:analysis / Q000097:blood*
D015415:Biomarkers; D018167:Receptors, Calcitriol; D065668:Vitamin D3 24-Hydroxylase
CYP24A1; Vitamin D receptor (VDR); end-stage renal disease (ESRD)