The Effect of Age on Dexamethasone Intravitreal Implant (Ozurdex®) Response in Macular Edema Secondary to Branch Retinal Vein Occlusion.
OBJECTIVE
To investigate the effect of age on dexamethasone intravitreal implant (Ozurdex®) response in macular edema secondary to branch retinal vein occlusion (BRVO).


METHODS
Seventy-three eyes of 73 patients with macular edema secondary to BRVO were recruited in the study. The patients in the study were divided into the following four groups according to their ages: group 1 (<60 years), group 2 (60-69 years), group 3 (70-79 years), and group 4 (≥80 years). Single-dose Ozurdex injection was applied to all patients. The effectiveness of Ozurdex treatment on macular edema is evaluated via optical coherence tomography (OCT) according to the age groups.


RESULTS
Two months after Ozurdex injection, mean reduction of central retinal thickness in groups 1, 2, 3, and 4 were -466.4 ± 149.6, -379.7 ± 238.7, -280.1 ± 233.0, and -180.5 ± 81.4 µm, respectively. This reduction of central retinal thickness decreased with aging (p = 0.001). Also, ages of patients were negatively correlated with the mean reduction of central retinal thickness for the whole study group (r = -0.439, p < 0.001).


CONCLUSIONS
Our study revealed that the effectiveness of Ozurdex treatment decreases with aging.
a Kayseri Education and Research Hospital , Department of Ophthalmology , Kayseri , Turkey.
Orhan
O
Altunel
a Kayseri Education and Research Hospital , Department of Ophthalmology , Kayseri , Turkey.
Altan
A
Göktaş
a Kayseri Education and Research Hospital , Department of Ophthalmology , Kayseri , Turkey.
Necati
N
Duru
a Kayseri Education and Research Hospital , Department of Ophthalmology , Kayseri , Turkey.
Ayşe
A
Özköse
a Kayseri Education and Research Hospital , Department of Ophthalmology , Kayseri , Turkey.
Hasan Basri
HB
Arifoğlu
a Kayseri Education and Research Hospital , Department of Ophthalmology , Kayseri , Turkey.
Mustafa
M
Ataş
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003907:Dexamethasone / Q000008:administration & dosage*; D004343:Drug Implants; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D058449:Intravitreal Injections; D008269:Macular Edema / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000473:pathology*; D012170:Retinal Vein Occlusion / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D041623:Tomography, Optical Coherence / Q000379:methods*; D016896:Treatment Outcome; D014792:Visual Acuity
D004343:Drug Implants; D005938:Glucocorticoids; D003907:Dexamethasone
Age; Dexamethasone intravitreal implant; Ozurdex; branch retinal vein occlusion; optical coherence tomography