Extracorporeal photopheresis did not prevent the development of an autoimmune disease: myasthenia gravis.
Myasthenia gravis (MG) is a neuromuscular disorder characterized by an autoimmune defect in the neuromuscular junction. In most patients, the autoimmune attack is mediated by antibodies against the acetylcholine receptor (AChR) on the postsynaptic membrane. Deficient immunoregulation, including regulatory T cells, is consistently observed. Extracorporeal photopheresis (ECP) leads to the induction of regulatory T cells that mediate immunologic tolerance in autoimmune diseases; however, the data regarding MG are very limited.



Here, we report a patient who, during ongoing ECP therapy for his severe, refractory, chronic graft-versus-host disease (cGVHD), developed MG, although he responded very well to ECP, as indicated by the lowering of his chronic cGVHD severity grade to moderate.



Despite receiving ECP, our patient developed MG, which was resistant to treatment and required intensive care unit support.



Close surveillance is required when ECP is planned as one of the treatment alternatives in myasthenia gravis that develop in cGVHD.
Pediatric Bone Marrow Transplantation Unit, Medical Park Antalya Hospital, Bahçeşehir University.
Vedat
V
Uygun
Pediatric Bone Marrow Transplantation Unit, Medical Park Antalya Hospital, Antalya, Turkey.
Hayriye
H
Daloğlu
Pediatric Bone Marrow Transplantation Unit, Medical Park Antalya Hospital, Antalya, Turkey.
Seda Irmak
SI
Öztürkmen
Intensive Care Unit, Istanbul Kemerburgaz University Faculty of Medicine.
Levent
L
Döşemeci
Pediatric Bone Marrow Transplantation Unit, Medical Park Göztepe Hospital, Bahçeşehir University.
Gülsün
G
Karasu
Pediatric Hematology and Oncology and Bone Marrow Transplantation Unit, Medipol University Faculty of Medicine, Istanbul, Turkey.
Volkan
V
Hazar
Pediatric Bone Marrow Transplantation Unit, Medical Park Antalya Hospital, Bahçeşehir University.
Akif
A
Yeşilipek
D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000150:complications / Q000628:therapy*; D006801:Humans; D008297:Male; D009157:Myasthenia Gravis / Q000209:etiology / Q000517:prevention & control* / Q000628:therapy; D017893:Photopheresis