High salivary soluble L-selectin and interleukin-7 levels in Asian Indian patients with primary Sjögren's syndrome.
In present study, we aimed to study salivary soluble L-selectin (sL-selectin), interleukin-7(IjL-7), and lymphotoxin-α levels in primary Sjögren's syndrome (pSS) and their clinical as well as serological correlations. pSS patients fulfilling either the American European Consensus Group (AECG) and/or the American college of Rheumatology (ACR) criteria were recruited. Age- and sex-matched hospital staff were recruited as healthy controls. Unstimulated saliva was collected by the spitting method; sL-selectin, IL-7, and lymphotoxin-α were measured in the saliva using commercial ELISA kits. Forty-three patients with pSS and 31 healthy controls were included in the study. Increased levels of sL-selectin and IL-7 were found in the saliva of patients as compared to controls. Lymphotoxin-α was undetectable in the saliva of pSS patients and controls. Salivary sL-selectin positively correlated with rheumatoid factor (r = 0.47; p < 0.003). No other variable including ESSDAI was significantly associated with salivary sL-selectin and IL-7 levels. Indian patients with primary Sjögren's syndrome have higher salivary sL-selectin and IL-7 levels than healthy controls.
Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, Tamil Nadu, 632004, India. Jayakanthan@cmcvellore.ac.in.
Jayakanthan
J
Kabeerdoss
Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, Tamil Nadu, 632004, India.
Pulukool
P
Sandhya
Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, Tamil Nadu, 632004, India.
Santosh Kumar
SK
Mandal
Department of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, India.
Mahasampath
M
Gowri
Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, Tamil Nadu, 632004, India.
Debashish
D
Danda
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000737:chemistry; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007194:India; D015851:Interleukin-7 / Q000737:chemistry*; D019041:L-Selectin / Q000737:chemistry*; D008233:Lymphotoxin-alpha / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000737:chemistry*; D012859:Sjogren's Syndrome / Q000378:metabolism*; D055815:Young Adult
D001323:Autoantibodies; C508605:IL7 protein, human; D015851:Interleukin-7; D008233:Lymphotoxin-alpha; C546935:SELL protein, human; D019041:L-Selectin
Interleukin-7; Lymphotoxin-α; Saliva; Sjögren’s syndrome; Soluble L-selectin