[Risk factors for early miscarriage among intrauterine singleton pregnancies after treatment with in vitro fertilization/intracytoplasmic sperm injection].
OBJECTIVE
To investigate the risk factors associated with early miscarriage among intrauterine singleton pregnancies after treatment with in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI).


METHODS
A retrospective case-control study was performed on all singleton pregnancies underwent IVF/ICSI from January, 2013 to May, 2014, in Xiangya Hospital. Ninety-six early miscarriage patients served as a case group and 593 pregnancies with live birth served as a control group. We analyzed factors for early miscarriage after IVF/ICSI in two groups.


RESULTS
Multivariate logistic regression analysis demonstrated that the women age, miscarriage history, and sperm DAN fragmentation index (DFI) were the risk factors for early miscarriage (P<0.05).


CONCLUSIONS
Miscarriage after treatment with IVF/ICSI is affected by multiple factors. Women at elder age (>30 years old), women with a history of miscarriage or men with higher sperm DFI (≥15%) are the risk.
Reproductive Medical Center, Xiangya Hospital, Central South University, Changsha 410008, China.
Hong
H
Zeng
Reproductive Medical Center, Xiangya Hospital, Central South University, Changsha 410008, China.
Nenghui
N
Liu
Reproductive Medical Center, Xiangya Hospital, Central South University, Changsha 410008, China.
Xiuli
X
Fan
Reproductive Medical Center, Xiangya Hospital, Central South University, Changsha 410008, China.
Muzhu
M
Cai
Office of National High-Tech Project, Changsha Central Hospital, Changsha 410004, China.
Hebin
H
Xie
D000022:Abortion, Spontaneous; D016022:Case-Control Studies; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008297:Male; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors; D020554:Sperm Injections, Intracytoplasmic; D013094:Spermatozoa