Using the Tools and Resources of the RCSB Protein Data Bank.
The Protein Data Bank (PDB) archive is the worldwide repository of experimentally determined three-dimensional structures of large biological molecules found in all three kingdoms of life. Atomic-level structures of these proteins, nucleic acids, and complex assemblies thereof are central to research and education in molecular, cellular, and organismal biology, biochemistry, biophysics, materials science, bioengineering, ecology, and medicine. Several types of information are associated with each PDB archival entry, including atomic coordinates, primary experimental data, polymer sequence(s), and summary metadata. The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB) serves as the U.S. data center for the PDB, distributing archival data and supporting both simple and complex queries that return results. These data can be freely downloaded, analyzed, and visualized using RCSB PDB tools and resources to gain a deeper understanding of fundamental biological processes, molecular evolution, human health and disease, and drug discovery. © 2016 by John Wiley & Sons, Inc.
RCSB Protein Data Bank, Department of Chemistry and Chemical Biology and Center for Integrative Proteomics Research, Rutgers, The State University of New Jersey, Piscataway, New Jersey.
Luigi Di
LD
Costanzo
RCSB Protein Data Bank, Department of Chemistry and Chemical Biology and Center for Integrative Proteomics Research, Rutgers, The State University of New Jersey, Piscataway, New Jersey.
Sutapa
S
Ghosh
RCSB Protein Data Bank, Department of Chemistry and Chemical Biology and Center for Integrative Proteomics Research, Rutgers, The State University of New Jersey, Piscataway, New Jersey.
Christine
C
Zardecki
RCSB Protein Data Bank, Department of Chemistry and Chemical Biology and Center for Integrative Proteomics Research, Rutgers, The State University of New Jersey, Piscataway, New Jersey.|Institute for Quantitative Biomedicine, Rutgers, The State University of New Jersey, Piscataway, New Jersey.|Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, California.|San Diego Supercomputer Center, University of California, San Diego, California.
Stephen K
SK
Burley
D019295:Computational Biology / Q000379:methods*; D030562:Databases, Protein; D006801:Humans; D011506:Proteins / Q000737:chemistry
D011506:Proteins
3D structure; drug discovery; ligand; macromolecule; search; single nucleotide variation