Rac-ing from Epithelial Secretor to Eater.
Mammary epithelial phagocytosis is critical for removal of apoptotic cells during involution, but the mechanisms governing this process are largely unknown. In this issue of Developmental Cell, Akhtar et al. (2016) provide insight into mechanisms regulating involution, demonstrating that Rac1 drives the switch from differentiation to phagocytosis in mammary epithelium.
School of Medical Sciences and Bosch Institute, Sydney Medical School, The University of Sydney, New South Wales 2006, Australia. Electronic address: matthew.naylor@sydney.edu.au.
Matthew J
MJ
Naylor
D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D002454:Cell Differentiation / Q000235:genetics; D004847:Epithelial Cells / Q000378:metabolism; D004848:Epithelium / Q000254:growth & development / Q000378:metabolism; D005260:Female; D006801:Humans; D008322:Mammals; D042361:Mammary Glands, Human / Q000254:growth & development / Q000378:metabolism / Q000473:pathology; D010587:Phagocytosis / Q000235:genetics*; D020830:rac1 GTP-Binding Protein / Q000235:genetics* / Q000378:metabolism
C107953:RAC1 protein, human; D020830:rac1 GTP-Binding Protein