Human papilloma virus genotypes in women from Nayarit, Mexico, with squamous intraepithelial lesions and cervical cancer.
OBJECTIVE
In Mexico cervical cancer (CC) is the most common cause of death from neoplasia in women. Study aimed to analyze the current distribution of Human papillomavirus (HPV) types in women from Nayarit, Mexico, with Squamous intraepithelial lesions (SIL) and Cervical cancer (CC).


METHODS
Between January 2011 and July 2013, cervical samples were collected from female residents of the Mexican state of Nayarit and were analyzed by means of a LINEAR ARRAY® HPV genotyping test. Data analyses were performed using Stata ver. 8.0 statistical software.


RESULTS
Of the samples analyzed, 91.2%, HPV DNA was detected. Of these positive samples, 82% were High-risk (HR) viral types. The most prevalent HPV genotypes identified were 16, 58, 31, 18, and 70. Forty two percent of participants had a single infection, while 23 and 26% of participants were infected with two or more HPV genotypes, respectively. HPV 16 was the most prevalent genotype identified and was frequently present as a co-infection with HPV types 18, 51, 52, 59, 66, or 70.


CONCLUSIONS
Women <20 years of age were most often infected with HPV, and the HPV Quadrivalent vaccine (types 16, 18, 6, and 11), currently available in Mexico, no confers protection against a subset of the HPV genotypes identified in the present study (58, 31, 70, and 35). Thus, it is important evaluate the geographical distribution of specific HPV genotypes in all health of center across Mexico in order to implement a successful vaccination program and to diagnose CC in its early stages.
Posgrado en Ciencias Biológico Agropecuarias. Universidad Autónoma de Nayarit.
Laura
L
Ortega-Cervantes
Centro de Investigación Biomédica de Occidente-IMSS, Guadalajara, Jalisco.
Adriana
A
Aguilar-Lemarroy
Laboratorio de Contaminación y Toxicología Ambiental, Secretaría de Investigación y Posgrado. Universidad Autónoma de Nayarit.
Aurora Elizabeth
AE
Rojas-García
Laboratorio de Contaminación y Toxicología Ambiental, Secretaría de Investigación y Posgrado. Universidad Autónoma de Nayarit.
Briscia Socorro
BS
Barrón-Vivanco
Centro de Investigación Biomédica de Oriente, IMSS de Metepec, Puebla.
Verónica
V
Vallejo-Ruiz
Instituto Nacional de Cancerología, México, DF.
David Cantú-De
DC
León
Laboratorio de Contaminación y Toxicología Ambiental, Secretaría de Investigación y Posgrado. Universidad Autónoma de Nayarit.
Yael Yvette Bernal
YY
Hernández
Hospital Civil Dr. Antonio González Guevara, Servicios de Salud de Nayarit.
Armando
A
Jáuregui-Martínez
Laboratorio de Contaminación y Toxicología Ambiental, Secretaría de Investigación y Posgrado. Universidad Autónoma de Nayarit.
Irma Martha
IM
Medina-Díaz