Asymmetric Hydrogenation of β-Aryloxy/Alkoxy Cinnamic Nitriles and Esters.
A highly efficient and enantioselective hydrogenation of β-aryloxy/alkoxy cinnamic nitriles and esters under mild conditions has been realized by using a rhodium catalyst with a chiral f-spiroPhos ligand. The method provides efficient access to the asymmetric synthesis of a variety of chiral β-oxy-functionalized nitriles and esters with excellent enantioselectivities (up to 99.9% ee) and high turnover numbers (TON of up to 50000). This methodology has also been successfully applied to the concise and practical synthesis of the chiral pharmaceutical nisoxetine.
College of Chemistry, Beijing Normal University , Beijing 100875, China.
Duanyang
D
Kong
College of Chemistry, Beijing Normal University , Beijing 100875, China.
Meina
M
Li
College of Chemistry, Beijing Normal University , Beijing 100875, China.
Rui
R
Wang
College of Chemistry, Beijing Normal University , Beijing 100875, China.
Guofu
G
Zi
College of Chemistry, Beijing Normal University , Beijing 100875, China.
Guohua
G
Hou