Pediatric Obsessive-Compulsive Disorder Exacerbation and Obstructive Hydrocephalus: A Case Report.
We present the case of an 11 year-old boy with a previous history of obsessive-compulsive disorder (OCD), who experienced a dramatic and acute worsening of OCD symptoms in temporal association with obstructive hydrocephalus secondary to a tectal low-grade glioma. Management and resolution of the hydrocephalus was temporally associated with an improvement in his OCD compulsion symptoms. The present case does not establish proof of cause and effect, but highlights potential multifactorial influences on OCD onset and clinical course. Cortico-striatal-thalamic-cortical pathways, physically distorted by hydrocephalus in this case, have long been implicated in OCD etiology. Clinical implications include the importance of conducting an appropriate neurologic work-up to rule out biological causes for acute and dramatic OCD exacerbations with neurologic signs, even in the context of preexisting OCD. Given that neurologic lesions may exist in the absence of typical signs and symptoms, that they may further disrupt OCD circuitry, and that treatment may lead to resolution of associated psychiatric symptoms, it is important to remain cognizant of these differential diagnoses.
Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.
Aldrich
A
Leung
Division of Psychiatry, British Columbia Children's Hospital, Vancouver, British Columbia, Canada; and.
Clare
C
Bleakley
Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.|Division of Psychiatry, British Columbia Children's Hospital, Vancouver, British Columbia, Canada; and.
Adrian
A
Loh
Division of Psychiatry, British Columbia Children's Hospital, Vancouver, British Columbia, Canada; and.
Kelly
K
Saran
Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada; evelyn.stewart@ubc.ca.|Division of Psychiatry, British Columbia Children's Hospital, Vancouver, British Columbia, Canada; and.|Harvard Medical School, Boston, Massachusetts.
S Evelyn
SE
Stewart
D001932:Brain Neoplasms / Q000150:complications; D002648:Child; D005473:Fluoxetine / Q000627:therapeutic use; D005910:Glioma / Q000150:complications; D006801:Humans; D006849:Hydrocephalus / Q000150:complications* / Q000209:etiology / Q000601:surgery; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000523:psychology* / Q000628:therapy*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D012720:Severity of Illness Index; D014696:Ventriculostomy
D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors