Neurons in the primate dorsal striatum signal the uncertainty of object-reward associations.
To learn, obtain reward and survive, humans and other animals must monitor, approach and act on objects that are associated with variable or unknown rewards. However, the neuronal mechanisms that mediate behaviours aimed at uncertain objects are poorly understood. Here we demonstrate that a set of neurons in an internal-capsule bordering regions of the primate dorsal striatum, within the putamen and caudate nucleus, signal the uncertainty of object-reward associations. Their uncertainty responses depend on the presence of objects associated with reward uncertainty and evolve rapidly as monkeys learn novel object-reward associations. Therefore, beyond its established role in mediating actions aimed at known or certain rewards, the dorsal striatum also participates in behaviours aimed at reward-uncertain objects.
Department of Neuroscience, Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA.
J Kael
JK
White
Department of Neuroscience, Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA.
Ilya E
IE
Monosov
D000818:Animals; D001245:Association Learning / Q000502:physiology*; D003342:Corpus Striatum / Q000502:physiology*; D008253:Macaca mulatta; D008297:Male; D009474:Neurons / Q000502:physiology*; D012201:Reward; D035501:Uncertainty