The Use of Exosomes as Biomarkers for Evaluating and Monitoring Critically Ill Polytrauma Patients with Sepsis.
Regarding genetic biomarkers for early assessment and monitoring the clinical course in polytrauma patients with sepsis, in recent years a remarkable evolution has been highlighted. One of the main representatives is the exosome miRNAs. In this paper, we would like to present in more details the various methods of using exosome miRNAs as a biomarker for monitoring polytrauma patients with sepsis, as well as establishing a belated outcome by aggregating the entire clinical aspects. The use of exosome miRNAs for late evaluating and monitoring the clinical evolution of polytrauma patients can bring significant improvements in current clinical practice through the optimization and modulation of intensive care according to the needs of each patient individually.
Faculty of Medicine and Pharmacy Oradea, University of Oradea, Oradea, Romania.
Marian
M
Ticlea
Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
Lavinia Melania
LM
Bratu
Faculty of Medicine and Pharmacy Oradea, University of Oradea, Oradea, Romania.
Florian
F
Bodog
Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.|Clinic of Anesthesia and Intensive Care, Emergency County Hospital "Pius Brinzeu" Timisoara, Bd. Iosif Bulbuca Nr.10, Timisoara, Romania.
Ovidiu Horea
OH
Bedreag
Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania. alexandru.rogobete@umft.ro.|Clinic of Anesthesia and Intensive Care, Emergency County Hospital "Pius Brinzeu" Timisoara, Bd. Iosif Bulbuca Nr.10, Timisoara, Romania. alexandru.rogobete@umft.ro.
Alexandru Florin
http://orcid.org/0000-0003-1286-4431
AF
Rogobete
Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
Zorin Petrisor
ZP
Crainiceanu
D015415:Biomarkers / Q000032:analysis*; D016638:Critical Illness; D055354:Exosomes / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D009104:Multiple Trauma / Q000175:diagnosis*; D018805:Sepsis / Q000175:diagnosis*
D015415:Biomarkers; D035683:MicroRNAs
Critically ill polytrauma patient; Epigenetic biomarkers; Exosomal miRNAs; Sepsis