Aptamer-Based Screens of Human Body Fluids for Biomarkers.
In recent years, aptamers have come to replace antibodies in high throughput multiplexed experiments. The aptamer-based biomarker screening technology, which kicked off in 2010, is capable of interrogating thousands of proteins in a very small sample volume. With this new technology, researchers hope to find clinically appropriate biomarkers for a myriad of illnesses by screening human body fluids. In this work, we have reviewed a total of eight studies utilizing aptamer-based biomarker screens of human body fluids, and have highlighted novel protein biomarkers discovered.
Department of Biomedical Engineering, University of Houston, 3605 Cullen Blvd, Houston, TX 77204, USA. dalbaba@uh.edu.
Dania
D
Albaba
Department of Biomedical Engineering, University of Houston, 3605 Cullen Blvd, Houston, TX 77204, USA. ssoomro2@uh.edu.
Sanam
S
Soomro
Department of Biomedical Engineering, University of Houston, 3605 Cullen Blvd, Houston, TX 77204, USA. cmohan@central.uh.edu.
Chandra
C
Mohan
aptamer; biomarker; diagnostics; immunoassay; microarray