mRNA expression profile of mouse oligodendrocytes in inflammatory conditions.
In this study, we performed transcriptome profiling of oligodendrocyte culture of mice treated with the remyelinating therapeutic agent benztropine in the presence and absence of interferon gamma (IFNγ). The results of this work are important for understanding the expression profile of oligodendrocytes under conditions of systemic inflammation in the central nervous system in multiple sclerosis as well as the mechanisms of cellular response to benztropine in light of its possible use for the treatment of multiple sclerosis.
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.
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Kudriaeva
BioKlinikum Scientific-Technical Center LLC, ul. Ugreshskaya 2, bdg. 85, Moscow, 115088, Russia.
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Khaustova
BioKlinikum Scientific-Technical Center LLC, ul. Ugreshskaya 2, bdg. 85, Moscow, 115088, Russia.
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Maltseva
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.
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Kuzina
Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, ul. Karla Marksa 74, Kazan, Tatarstan, 420055, Russia.
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Glagoleva
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.
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Surina
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia. vera.knorre@gmail.com.
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Knorre
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.|Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, ul. Karla Marksa 74, Kazan, Tatarstan, 420055, Russia.
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Belogurov
BioKlinikum Scientific-Technical Center LLC, ul. Ugreshskaya 2, bdg. 85, Moscow, 115088, Russia.
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Tonevitsky
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.|Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, ul. Karla Marksa 74, Kazan, Tatarstan, 420055, Russia.|Faculty of Chemistry, Moscow State University, Moscow, 119991, Russia.
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Gabibov
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001590:Benztropine / Q000494:pharmacology; D002478:Cells, Cultured; D020869:Gene Expression Profiling; D007155:Immunologic Factors / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology; D008809:Mice, Inbred C3H; D009836:Oligodendroglia / Q000187:drug effects / Q000276:immunology*; D046988:Proteasome Endopeptidase Complex / Q000187:drug effects / Q000276:immunology; D012333:RNA, Messenger / Q000276:immunology*; D059467:Transcriptome / Q000187:drug effects / Q000276:immunology*
D000893:Anti-Inflammatory Agents; D007155:Immunologic Factors; D012333:RNA, Messenger; D001590:Benztropine; D007371:Interferon-gamma; D046988:Proteasome Endopeptidase Complex