Regioselective Synthesis of 2,3,4-Trisubstituted Pyrroles via Pd(II)-Catalyzed Three-Component Cascade Reactions of Amines, Alkyne Esters, and Alkenes.
A new, efficient, and versatile Pd(II)-catalyzed oxidative three-component cascade reaction of diverse amines, alkyne esters, and alkenes is disclosed for the direct synthesis of diverse 2,3,4-trisubstituted pyrroles with broad functional group tolerance and in good to excellent yields. This transformation is supposed to proceed through the cascade formation of C(sp2)-C(sp2) and C(sp2)-N bonds via Pd(II)-catalyzed regioselective alkene migratory insertion, intramolecular radical addition, and oxidation sequential processes.
College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University , Nanyang 473061, China.
Xu
X
Zhang
College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University , Nanyang 473061, China.
Xuefeng
X
Xu
China Gateway Pharmaceutical Development Company, Limited, Shanghai 201417, China.
Gong
G
Chen
VARI/SIMM Center, Center for Structure and Function of Drug Targets, CAS-Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, China.
Wei
W
Yi