Influence of TRPV4 gene polymorphisms on the development of osmotic airway hyperresponsiveness in patients with bronchial asthma.
The effect of single nucleotide polymorphisms (SNP) of TRPV4 gene on the development of airway hyperresponsiveness (39.7% of cases) in response to the decrease in osmolarity under inspiration of distilled water aerosol was studies in 189 patients with uncontrolled bronchial asthma. rs6606743 SNP was found to significantly contribute to the development of osmotic airway hyperresponsiveness. Analysis of the dominant genetic model revealed substantial prevalence of AG + GG genotype frequency in the group of patients with asthma with osmotic hyperresponsiveness in comparison with the patients who had negative response to bronchoprovocation. In addition, carriers of GG or AG genotypes had significantly more profound decrease of lung function parameters in relation to A homozygous patients.
Far Eastern Research Center of Physiology and Pathology of Respiration, ul. Kalinina 22, Blagoveshchensk, 675000, Russia. denn1985@bk.ru.
D E
DE
Naumov
Far Eastern Research Center of Physiology and Pathology of Respiration, ul. Kalinina 22, Blagoveshchensk, 675000, Russia.
V P
VP
Kolosov
Far Eastern Research Center of Physiology and Pathology of Respiration, ul. Kalinina 22, Blagoveshchensk, 675000, Russia.
J M
JM
Perelman
Far Eastern Research Center of Physiology and Pathology of Respiration, ul. Kalinina 22, Blagoveshchensk, 675000, Russia.
A G
AG
Prikhodko
D000328:Adult; D000336:Aerosols / Q000008:administration & dosage; D001249:Asthma / Q000235:genetics* / Q000503:physiopathology*; D005787:Gene Frequency; D060005:Genotyping Techniques; D006579:Heterozygote; D006801:Humans; D001239:Inhalation / Q000235:genetics / Q000502:physiology; D040582:Inheritance Patterns; D008957:Models, Genetic; D009994:Osmolar Concentration; D020641:Polymorphism, Single Nucleotide; D012129:Respiratory Function Tests; D012720:Severity of Illness Index; D013147:Spirometry; D050916:TRPV Cation Channels / Q000235:genetics*; D014867:Water / Q000008:administration & dosage
D000336:Aerosols; D050916:TRPV Cation Channels; C416986:TRPV4 protein, human; D014867:Water