Phenolic compounds and anticancer activity of commercial sugarcane cultivated in Brazil.
The cultivation of sugarcane hybrids (X Saccharum officinarum L.) is an important revenue source for the Brazilian economy. Herein it is reported the evaluation of the cytotoxic activity of mid-polarity sugarcane extracts against human cancer cell lines, as well as the isolation of steroids sitosterol, stigmasterol and campesterol, phenolic acids p-hydroxybenzoic, p-hydroxycinnamic, vanillic and ferulic acid, terpenoids α-tocopherol and β-carotene and a novel substance in sugarcane, the flavonoid aglycone tricin (5,7,4-trihydroxy-3,5-dimethoxyflavone). The presence of large amounts of phenolic acids and the flavonoid tricin may explain the cytostatic activity observed for the mid-polarity crude extract and filtrates.
Universidade Estadual de Maringá/UEM, Departamento de Química, Avenida Colombo, 5790, 87020-900 Maringá, PR, Brasil.
Vanessa G
VG
Alves
Universidade Estadual de Maringá/UEM, Departamento de Química, Avenida Colombo, 5790, 87020-900 Maringá, PR, Brasil.
Alan G
AG
Souza
Universidade Estadual de Maringá/UEM, Departamento de Química, Avenida Colombo, 5790, 87020-900 Maringá, PR, Brasil.
Lucas U R
LU
Chiavelli
Universidade Estadual de Campinas, CPQBA, Instituto de Química, Rua Alexandre Cazellato, 999, 13081-970 Paulínia, SP, Brasil.
Ana L T G
AL
Ruiz
Universidade Estadual de Campinas, CPQBA, Instituto de Química, Rua Alexandre Cazellato, 999, 13081-970 Paulínia, SP, Brasil.
João E
JE
Carvalho
Universidade Estadual de Maringá/UEM, Departamento de Química, Avenida Colombo, 5790, 87020-900 Maringá, PR, Brasil.
Armando M
AM
Pomini
Universidade Estadual de Maringá/UEM, Departamento de Química, Avenida Colombo, 5790, 87020-900 Maringá, PR, Brasil.
Cleuza C
CC
Silva
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D001938:Brazil; D045744:Cell Line, Tumor; D006801:Humans; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D031786:Saccharum / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D010636:Phenols; D010936:Plant Extracts