Early onset steroid induced posterior subcapsular cataract in a patient with common variable immunodeficiency: case reports and review of literature.
Purpose. To report early onset steroid induced posterior subcapsular cataract in a case of common variable immunodeficiency. Methods. Case report. Results. Here we report a 14-yearold male of steroid induced bilateral posterior subcapsular cataract in a common variable immunodeficiency patient with damaging mutations in Glutathione reductase gene, leading to hypersensitivity of patient to glucocorticoid (GC) products. Conclusions. In order to reduce the ocular side effects of the GCs there are some advisements, including a complete history, regular examination, GC should be prescribed in minimal dosage and minimal course, and as possible GC-sparing drugs should always be considered.
Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
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Marefat
Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden.
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Abolhassani
Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
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Ghareje Daghi
Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran.
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Azizi
Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Phone: +98 21 6642 8998 Fax: +98 21 6692 3054 Mobile: +98 9121 5939 56 E-mail: aghamohammadi@sina.tums.ac.ir.
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Aghamohammadi
D000293:Adolescent; D002386:Cataract / Q000139:chemically induced* / Q000175:diagnosis / Q000235:genetics; D017074:Common Variable Immunodeficiency / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D004252:DNA Mutational Analysis; D020022:Genetic Predisposition to Disease; D005938:Glucocorticoids / Q000009:adverse effects*; D005980:Glutathione Reductase / Q000235:genetics; D006801:Humans; D008297:Male; D009154:Mutation; D010641:Phenotype; D057852:Posterior Capsule of the Lens / Q000187:drug effects* / Q000473:pathology; D011241:Prednisone / Q000009:adverse effects*; D012307:Risk Factors; D013997:Time Factors
D005938:Glucocorticoids; D005980:Glutathione Reductase; D011241:Prednisone
common variable immunodeficiency; glucocorticoid; glutathione reductase gene mutations; posterior subcapsular cataract