Fast-Dissolving, Prolonged Release, and Antibacterial Cyclodextrin/Limonene-Inclusion Complex Nanofibrous Webs via Polymer-Free Electrospinning.
We have proposed a new strategy for preparing free-standing nanofibrous webs from an inclusion complex (IC) of a well-known flavor/fragrance compound (limonene) with three modified cyclodextrins (HPβCD, MβCD, and HPγCD) via electrospinning (CD/limonene-IC-NFs) without using a polymeric matrix. The experimental and computational modeling studies proved that the stoichiometry of the complexes was 1:1 for CD/limonene systems. MβCD/limonene-IC-NF released much more limonene at 37, 50, and 75 °C than HPβCD/limonene-IC-NF and HPγCD/limonene-IC-NF because of the greater amount of preserved limonene. Moreover, MβCD/limonene-IC-NF has released only 25% (w/w) of its limonene, whereas HPβCD/limonene-IC-NF and HPγCD/limonene-IC-NF released 51 and 88% (w/w) of their limonene in 100 days, respectively. CD/limonene-IC-NFs exhibited high antibacterial activity against E. coli and S. aureus. The water solubility of limonene increased significantly and CD/limonene-IC-NFs were dissolved in water in a few seconds. In brief, CD/limonene-IC-NFs with fast-dissolving character enhanced the thermal stability and prolonged the shelf life along with antibacterial properties could be quite applicable in food and oral care applications.
Institute of Materials Science & Nanotechnology, Bilkent University , Ankara 06800, Turkey.|UNAM-National Nanotechnology Research Center, Bilkent University , Ankara 06800, Turkey.
Zeynep
Z
Aytac
Institute of Materials Science & Nanotechnology, Bilkent University , Ankara 06800, Turkey.|UNAM-National Nanotechnology Research Center, Bilkent University , Ankara 06800, Turkey.
Zehra Irem
ZI
Yildiz
Institute of Materials Science & Nanotechnology, Bilkent University , Ankara 06800, Turkey.|UNAM-National Nanotechnology Research Center, Bilkent University , Ankara 06800, Turkey.
Fatma
F
Kayaci-Senirmak
UNAM-National Nanotechnology Research Center, Bilkent University , Ankara 06800, Turkey.|Department of Biology, Polatlı Faculty of Literature and Science, Gazi University , Ankara 06900, Turkey.|Life Sciences Application and Research Center, Gazi University , Ankara 06830, Turkey.
Nalan Oya
NO
San Keskin
UNAM-National Nanotechnology Research Center, Bilkent University , Ankara 06800, Turkey.|Department of Engineering Physics, Istanbul Medeniyet University , Istanbul 34700, Turkey.
Semran Ipek
SI
Kusku
Institute of Materials Science & Nanotechnology, Bilkent University , Ankara 06800, Turkey.|UNAM-National Nanotechnology Research Center, Bilkent University , Ankara 06800, Turkey.
Engin
E
Durgun
Life Sciences Application and Research Center, Gazi University , Ankara 06830, Turkey.|Department of Medical Biology and Genetics, Faculty of Medicine, Gazi University , Ankara 06560, Turkey.
Turgay
T
Tekinay
Institute of Materials Science & Nanotechnology, Bilkent University , Ankara 06800, Turkey.|UNAM-National Nanotechnology Research Center, Bilkent University , Ankara 06800, Turkey.
Tamer
T
Uyar
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D039301:Computers, Molecular; D018360:Crystallography, X-Ray; D003505:Cyclodextrins / Q000737:chemistry*; D053138:Cyclohexenes / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D004355:Drug Stability; D004926:Escherichia coli / Q000187:drug effects; D000077222:Limonene; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D057139:Nanofibers / Q000737:chemistry*; D009822:Oils, Volatile / Q000737:chemistry; D010316:Particle Size; D012995:Solubility; D013211:Staphylococcus aureus / Q000187:drug effects; D013729:Terpenes / Q000737:chemistry*; D013818:Thermogravimetry
D000900:Anti-Bacterial Agents; D003505:Cyclodextrins; D053138:Cyclohexenes; D004337:Drug Carriers; D009822:Oils, Volatile; D013729:Terpenes; D000077222:Limonene
antibacterial activity; computational modeling; electrospinning; essential oil; modified cyclodextrins