Multifocal epithelial hyperplasia: a forgotten condition in the elderly.
Multifocal epithelial hyperplasia (MEH), also known as focal epithelial hyperplasia and Heck disease, is a relatively rare condition caused by the human papillomavirus. This case report describes a 92-year-old man who presented with multiple, asymptomatic, circumscribed, soft, flattened papules in different sizes on the retrocommissure of his lower lip. The lesions were of 2 months' duration and had the same coloration as the adjacent normal mucosa. Histopathologic examination showed orthokeratinized stratified squamous epithelium with acanthosis, some areas of club-shaped rete ridges, and a few superficial epithelial cells with koilocytic changes and a mitosoid-like appearance. A diagnosis of MEH was established. Although MEH tends to occur in the first 2 decades of life, it can be encountered in elderly patients as well.
Nafiseh
N
Shamloo
Hamed
H
Mortazavi
Nasim
N
Taghavi
Maryam
M
Baharvand
D000369:Aged, 80 and over; D017573:Focal Epithelial Hyperplasia / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008046:Lip / Q000473:pathology; D008297:Male; D009061:Mouth Mucosa / Q000473:pathology
Heck disease; elderly; multifocal epithelial hyperplasia