[Fermented milk can act as adjunctive therapy for Helicobacter pylori infection: A Meta-analysis].
OBJECTIVE
To systematically evaluate the clinical effect of cultured milk products as adjunctive therapy in the anti- Helicobacter pylori (H. pylori) treatment.


METHODS
The randomized controlled trials (RCT) and Quasi-randomized controlled clinical trials (Quasi-RCT), which were used to evaluate the efficacy and safety of eradicating H. pylori by fermented milk-based routine treatment, were searched and collected in Pubmed, Embase, CNKI (China National Knowledge Infrastructure), CBM (Chinese BioMedical Literature Database), Wangfang Database, VIP (VIP Citation Database) from establishment of these database to February 2015. The combined relative risk (RR) of H. pylori eradication rate and the rate of side effects were analyzed. Sub-group and sensitivity analysis was performed, and the publication bias was also tested.


RESULTS
A total of 9 studies including 1 644 cases were identified. The H. pylori eradication rate was 79.5% in fermented milk products combined with routine therapy, and 67.0% in routine therapy. The combined RR of H. pylori eradication rate was 1.186 (95% CI 1.118-1.257), and the combined RR of total side effects was 0.706 (95% CI 0.373-1.340).


CONCLUSIONS
Cultured milk products as adjunctive therapy is effective in improving the eradication rate during eradication therapy for H. pylori. However, it could not effectively decrease the risk of side effects.
Department of Health Inspection and Quarantine, West China School of Public Health, Sichuan University, Chengdu 610041, China.
Yue
Y
Guo
Department of Nutrition, Food safety and Toxicology, West China School of Public Health, Sichuan University, Chengdu 610041, China.
Shuyue
S
Wang
Department of Nutrition, Food safety and Toxicology, West China School of Public Health, Sichuan University, Chengdu 610041, China.
Xi
X
Shen
Department of Nutrition, Food safety and Toxicology, West China School of Public Health, Sichuan University, Chengdu 610041, China.
Miao
M
He
Department of Nutrition, Food safety and Toxicology, West China School of Public Health, Sichuan University, Chengdu 610041, China.
Lei
L
Shi
Department of Nutrition, Food safety and Toxicology, West China School of Public Health, Sichuan University, Chengdu 610041, China.
Ming
M
Li
Department of Nutrition, Food safety and Toxicology, West China School of Public Health, Sichuan University, Chengdu 610041, China.
Chengyu
C
Huang
Department of Nutrition, Food safety and Toxicology, West China School of Public Health, Sichuan University, Chengdu 610041, China.
Fang
F
He
D000818:Animals; D002681:China; D003131:Combined Modality Therapy; D005285:Fermentation; D016481:Helicobacter Infections; D016480:Helicobacter pylori; D006801:Humans; D008892:Milk; D016032:Randomized Controlled Trials as Topic