Effect of Cytokine Signaling 3 Gene Polymorphisms in Childhood Obesity.
Although polymorphisms in suppressor of cytokine signaling 3 (SOCS3) was reported to be related to obesity, Metabolic syndrome (MS), and type 2 diabetes mellitus in various adult studies, there is a lack of data in children. In this study, we examined eight reported polymorphisms of SOCS3 in obese Turkish children and adolescent with and without MS and compared the results with that of controls.



One hundred and forty eight obese and 63 age- and sex-matched control subjects were enrolled in the study. Obesity classification was carried out according to body mass index. World Health Organization and National Cholesterol Education Program criteria were used for the diagnosis of MS. Genotyping procedure was carried out by polymerase chain reaction and Sanger sequencing protocol.



The frequency of rs2280148 polymorphism was significantly higher in obese subjects with MS than in the control group, whereas the frequency of rs8064821 polymorphism was significantly higher in obese subjects with MS than in obese children without MS.



The significant associations of certain SOCS3 polymorphisms with obesity parameters in both MS and MS -related insulin resistance, hypertension, and fatty liver suggest that polymorphisms in this gene may play a role in the pathogenesis of MS and also that they can be potentially used as a marker for attenuated or aggressive disease.
Mehmet
M
Boyraz
Ediz
E
Yeşilkaya
Fatih
F
Ezgü
Aysun
A
Bideci
Haldun
H
Doğan
Marmara University Faculty of Dentistry, Department of Medical Biology and Genetics, İstanbul, Turkey, Phone: +90 216 400 22 22- 2409 E-mail: korkutulucan@hotmail.com.
Korkut
K
Ulucan
Peyami
P
Cinaz
D000293:Adolescent; D000483:Alleles; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002648:Child; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications / Q000235:genetics; D063766:Pediatric Obesity / Q000097:blood / Q000150:complications / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D000071223:Suppressor of Cytokine Signaling 3 Protein / Q000235:genetics*; D014421:Turkey
D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; C106644:SOCS3 protein, human; D000071223:Suppressor of Cytokine Signaling 3 Protein