Advances in the Urinary Exosomes in Renal Diseases.
Cells secrete around 30- 100 nm membrane-enclosed vesicles that are released into the extracellular spaceis termed exosomes(EXs). EXs widely present in body fluids and incorporated proteins,nucleic acids that reflect the physiological state of their cells of origin and they may play an important role in cell-to-cell communication in various physiological and disease processes. In this article we review the recent basic and clinical studies in urinary EXs in renal diseases,focusing on their biological characteristics and potential roles as new biological markers,intervention treatment goals,and targeted therapy vectors in renal diseases.However,some issues still exist;in particular,the clinical application of EXs as a liquid biopsy technique warrants further investigations.
Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
Pei-Pei
PP
Chen
Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
Yan
Y
Qin
Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
Xue-Mei
XM
Li
D015415:Biomarkers / Q000652:urine*; D002450:Cell Communication; D055354:Exosomes; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis*
D015415:Biomarkers