Copper-Catalyzed Decarboxylative Atom Transfer Radical Addition of Iododifluoroacetate to Alkynyl Carboxylic Acids.
The first example of copper-catalyzed decarboxylative atom transfer radical addition of alkynyl carboxylic acids has been developed with a readily available fluoroalkyl halide. This novel protocol has demonstrated a unique difunctionalization of nonterminal alkynes with a broad substrate scope and excellent functional-group tolerance. Mechanistic investigations revealed that the catalytic cycle was initiated by the attack of a difluoroalkyl radical to an in situ generated alkynylcopper species.
Department of Chemistry, University of Science and Technology of China , Hefei 230026, China.
Gang
G
Li
Department of Chemistry, University of Science and Technology of China , Hefei 230026, China.
Yi-Xuan
YX
Cao
Department of Chemistry, University of Science and Technology of China , Hefei 230026, China.
Chen-Guang
CG
Luo
Department of Chemistry, University of Science and Technology of China , Hefei 230026, China.
Yi-Ming
YM
Su
Department of Chemistry, University of Science and Technology of China , Hefei 230026, China.
Yan
Y
Li
Department of Chemistry, University of Science and Technology of China , Hefei 230026, China.
Quan
Q
Lan
Department of Chemistry, University of Science and Technology of China , Hefei 230026, China.|Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry , Shanghai, 200032, China.
Xi-Sheng
XS
Wang