Biomimetic Salmonella: A Next-Generation Therapeutic Vector?
Designing bacterial vectors for cancer therapy represents a major challenge. Recent studies have explored novel strategies to balance benefit and safety. A study by Mercado-Lubo et al. has developed a next-generation concept combining bacterial properties with nanoparticles, demonstrating efficacy in combination with chemotherapeutics.
Department of Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany. Electronic address: Sebastian.Felgner@helmholtz-hzi.de.
Sebastian
S
Felgner
Department of Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Dino
D
Kocijancic
Department of Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany; Institute of Immunology, Medical School Hannover, Hannover, Germany.
Vinay
V
Pawar
Department of Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany; Institute of Immunology, Medical School Hannover, Hannover, Germany.
Siegfried
S
Weiss
D001426:Bacterial Proteins / Q000494:pharmacology; D001691:Biological Therapy / Q000379:methods; D032701:Biomimetics / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods*; D004358:Drug Therapy; D008840:Microfilament Proteins / Q000494:pharmacology; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy; D030781:Organisms, Genetically Modified; D012486:Salmonella typhimurium / Q000166:cytology* / Q000235:genetics
D001426:Bacterial Proteins; D008840:Microfilament Proteins; C118287:SipA protein, Salmonella
Salmonella Typhimurium; Salmonella-mediated tumor therapy; SipA; nanoparticles