Cancer Salivary Biomarkers for Tumours Distant to the Oral Cavity.
The analysis of saliva as a diagnostic approach for systemic diseases was proposed just two decades ago, but recently great interest in the field has emerged because of its revolutionary potential as a liquid biopsy and its usefulness as a non-invasive sampling method. Multiple molecules isolated in saliva have been proposed as cancer biomarkers for diagnosis, prognosis, drug monitoring and pharmacogenetic studies. In this review, we focus on the current status of the salivary diagnostic biomarkers for different cancers distant to the oral cavity, noting their potential use in the clinic and their applicability in personalising cancer therapies.
Department of Surgery and Surgical Medical Specialties, Medicine and Dentistry School, University of Santiago de Compostela, Santiago de Compostela 15782, Spain. oscarr16691@gmail.com.
Óscar
Ó
Rapado-González
Biomedical Research Unit in Gynecology, Vall Hebron Research Institute (VHIR) and University Hospital, Autonomous University of Barcelona, Barcelona 08035, Spain. blanca.majem@vhir.org.
Blanca
B
Majem
Liquid Biopsy Analysis Unit, Health Research Institute of Santiago (IDIS), Complexo Hospitalario Universitario de Santiago de Compostela (SERGAS), Santiago de Compostela 15706, Spain. lmuirom@gmail.com.
Laura
L
Muinelo-Romay
Liquid Biopsy Analysis Unit, Health Research Institute of Santiago (IDIS), Complexo Hospitalario Universitario de Santiago de Compostela (SERGAS), Santiago de Compostela 15706, Spain. rafa.lopez.lopez@gmail.com.|Translational Medical Oncology, Health Research Institute of Santiago (IDIS), Complexo Hospitalario Universitario de Santiago de Compostela (SERGAS), Santiago de Compostela 15706, Spain. rafa.lopez.lopez@gmail.com.
Rafa
R
López-López
Department of Surgery and Surgical Medical Specialties, Medicine and Dentistry School, University of Santiago de Compostela, Santiago de Compostela 15782, Spain. mariamercedes.suarez@usc.es.
María Mercedes
MM
Suarez-Cunqueiro
D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D057285:Precision Medicine; D012463:Saliva / Q000378:metabolism*
D014408:Biomarkers, Tumor; D035683:MicroRNAs
biomarkers; cancer; non-invasive diagnosis; saliva; systemic diseases