Synthesis of Tetrahydro-1H-indeno[1,2-b]pyridine via Cascade Cyclization and Friedel-Crafts Reaction.
A convenient protocol has been established for the synthesis of 1-tosyl-2,3,4,5-tetrahydro-1H-indeno[1,2-b]pyridine via cascade cyclization and Friedel-Crafts reaction of 4-methyl-N-(pent-4-yn-1-yl)benzenesulfonamides and aldehydes in good yields. The methodology has been used for the total synthesis of the antidepressant agent (±)-5-phenyl-2,3,4,4a,5,9b-hexahydro-1H-indeno[1,2-b]pyridine.
Department of Chemistry, Indian Institute of Technology Guwahati , Guwahati 781039, India.
Upasana
U
Borthakur
Department of Chemistry, Indian Institute of Technology Guwahati , Guwahati 781039, India.
Madhurjya
M
Borah
Department of Chemistry, Indian Institute of Technology Guwahati , Guwahati 781039, India.
Manash J
MJ
Deka
Department of Chemistry, Indian Institute of Technology Guwahati , Guwahati 781039, India.
Anil K
AK
Saikia