Fabrication of autofluorescent porous silica nanoparticles for redox-responsive drug release.
Porous silica nanoparticles were prepared by emulsion-condensation route. The silica nanoparticles with diameter of 50nm have both accessible center-radial large pore channels (19.9nm) and small pore size of 3.5nm. The hierarchical porous structure endows them large pore volume for loading drugs and sustained release property. The silica nanoparticles were further modified with glucose-oxidized glutathione. The formulated Schiff base and disulfide bonds render the silica nanoparticles auto-fluorescent and redox-responsive properties. The cleavage of disulfide bonds caused by reactive thiols facilitates aminomethylbenzoic acid (AMA) release. The release of drug leads to the loss of fluorescence, which would be used to monitor the drug delivery and carrier distribution.
Engineering Research Center for Nanomaterials, Henan University, Kaifeng 475004, PR China.
Na
N
Cao
Engineering Research Center for Nanomaterials, Henan University, Kaifeng 475004, PR China. Electronic address: yanbaozhao@126.com.
Yanbao
Y
Zhao
Engineering Research Center for Nanomaterials, Henan University, Kaifeng 475004, PR China.
Bin
B
Sang
College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, PR China.
Zhihua
Z
Wang
College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, PR China.
Liuqin
L
Cao
Engineering Research Center for Nanomaterials, Henan University, Kaifeng 475004, PR China.
Lei
L
Sun
Engineering Research Center for Nanomaterials, Henan University, Kaifeng 475004, PR China.
Xueyan
X
Zou
D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D005947:Glucose / Q000737:chemistry; D005978:Glutathione / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D010084:Oxidation-Reduction; D010316:Particle Size; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D062366:para-Aminobenzoates / Q000737:chemistry* / Q000378:metabolism
D004337:Drug Carriers; D062366:para-Aminobenzoates; C015668:4-aminomethylbenzoic acid; D012822:Silicon Dioxide; D005978:Glutathione; D005947:Glucose
Drug release; Fluorescence; GSH-responsive; Nanoparticles; Porous silica