Genus Calliophis of Asiatic coral snakes: A deficiency of venom cross-reactivity and neutralization against seven regional elapid antivenoms.
Venoms of Calliophis bivirgata and Calliophis intestinalis exhibited moderate binding activities toward Neuro Bivalent Antivenom (Taiwan) but not the other six elapid monovalent or bivalent antivenoms available in the region. All antivenoms failed to neutralize C. bivirgata venom lethality in mice. The findings indicate the need to validate antivenom cross-reactivity with in vivo cross-neutralization, and imply that distinct antigens of Calliophis venoms should be incorporated in the production of a pan-regional poly-specific antivenom.
Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: tanch@um.edu.my.
Choo Hock
CH
Tan
Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Jia Lee
JL
Liew
Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Kae Yi
KY
Tan
Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Nget Hong
NH
Tan
D000818:Animals; D000997:Antivenins / Q000276:immunology*; D003429:Cross Reactions; D004546:Elapid Venoms / Q000276:immunology*; D017815:Elapidae; D051379:Mice; D009500:Neutralization Tests
D000997:Antivenins; D004546:Elapid Venoms
Antigen binding; Antivenom; Calliophis bivirgata; Calliophis intestinalis; Cross-neutralization; ELISA