Streptavidin Modified ZnO Film Bulk Acoustic Resonator for Detection of Tumor Marker Mucin 1.
A ZnO-based film bulk acoustic resonator has been fabricated using a magnetron sputtering technology, which was employed as a biosensor for detection of mucin 1. The resonant frequency of the thin-film bulk acoustic resonator was located near at 1503.3 MHz. The average electromechanical coupling factor [Formula: see text] and quality factor Q were 2.39 % and 224, respectively. Using the specific binding system of avidin-biotin, the streptavidin was self-assembled on the top gold electrode as the sensitive layer to indirectly test the MUC1 molecules. The resonant frequency of the biosensor decreases in response to the mass loading in range of 20-500 nM. The sensor modified with the streptavidin exhibits a high sensitivity of 4642.6 Hz/nM and a good selectivity.
Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Faculty of Physics and Electronic Science, Hubei University, Wuhan, 430062, China.|Faculty of Electronic and Engineering, Vocational College of WuHan Software Engineering, WuHan, 430205, China.
Dan
D
Zheng
Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Faculty of Physics and Electronic Science, Hubei University, Wuhan, 430062, China.
Peng
P
Guo
Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Faculty of Physics and Electronic Science, Hubei University, Wuhan, 430062, China. 190697922@qq.com.
Juan
J
Xiong
Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Faculty of Chemistry and Chemical Engineering, Hubei University, Wuhan, 430062, China.
Shengfu
S
Wang
Biosensor; Mucin 1; Resonant frequency; Thin-film bulk acoustic resonator; ZnO film