Serum irisin and its regulation by hyperinsulinemia in women with polycystic ovary syndrome.
Irisin is an adipokine/myokine which could be connected with insulin sensitivity. Polycystic ovary syndrome (PCOS) is characterized by oligo- or anovulation, polycystic ovary, hyperandrogenism and insulin resistance. The aim of the present study was to determine the relationship between serum irisin concentration and insulin sensitivity (Mffm) as well as the effect of insulin infusion on circulating irisin levels in PCOS women as compared with healthy controls. Seventy seven women were enrolled in the study - 57 with PCOS and 20 healthy controls matched for BMI and age. Hyperinsulinemic euglycemic clamps were performed in all of the study participants. The serum concentrations of irisin at baseline and after the clamp, as well as changes of serum irisin concentration in response to insulin supplied during the clamp (Δ irisin), were estimated. The mean serum concentrations of irisin at baseline and after hyperinsulinemia were higher in PCOS women in comparison to the control group (p=0.01; p=0.006, respectively). Insulin infusion resulted in a decrease of serum irisin concentration only in the PCOS group (p=0.007). In the control group, Δ irisin positively correlated with Mffm(r=0.56, p=0.009). In the entire group, multiple regression analysis showed that Δ irisin (β=0.70, p=0.0002), FFAs 60' during the clamp study (β=-0.22, p=0.01), SHBG (β=0.54, p<0.0001) and the interaction between Δ irisin and PCOS (β=-0.67, p=0.0004) were significantly associated with Mffm. The higher serum irisin concentrations at baseline and in response to insulin infusion might be secondary to insulin resistant conditions in PCOS women.
Department of the Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok 15-089, Poland.
Agnieszka
A
Adamska
Monika
M
Karczewska-Kupczewska
Agnieszka
A
Lebkowska
Robert
R
Milewski
Maria
M
Górska
Elzbieta
E
Otziomek
Agnieszka
A
Nikolajuk
Slawomir
S
Wolczynski
Irina
I
Kowalska
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005353:Fibronectins / Q000097:blood*; D015309:Glucose Clamp Technique; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood / Q000150:complications; D006946:Hyperinsulinism / Q000097:blood* / Q000139:chemically induced; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D009765:Obesity / Q000097:blood / Q000150:complications; D050177:Overweight / Q000097:blood / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications; D012189:Retrospective Studies; D013851:Thinness / Q000097:blood / Q000150:complications; D055815:Young Adult
C577593:FNDC5 protein, human; D005353:Fibronectins; D007328:Insulin