Role of sleep quality in the metabolic syndrome.
Emerging evidence has assigned an important role to sleep as a modulator of metabolic homeostasis. The impact of variations in sleep duration, sleep-disordered breathing, and chronotype to cardiometabolic function encompasses a wide array of perturbations spanning from obesity, insulin resistance, type 2 diabetes, the metabolic syndrome, and cardiovascular disease risk and mortality in both adults and children. Here, we critically and extensively review the published literature on such important issues and provide a comprehensive overview of the most salient pathophysiologic pathways underlying the links between sleep, sleep disorders, and cardiometabolic functioning.
Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, Department of Medicine; Section of Pediatric Sleep Medicine.
Dorit
D
Koren
Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, Department of Medicine.
Magdalena
M
Dumin
Section of Pediatric Sleep Medicine; Section of Pulmonology, Department of Pediatrics, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL, USA.
David
D
Gozal
cardiovascular risk; circadian clock; insulin resistance; obesity; sleep apnea