Gold nanoparticles synthesized using Panax ginseng leaves suppress inflammatory - mediators production via blockade of NF-κB activation in macrophages.
In the present study, we report that Gold nanoparticles (AuNPs) synthesized using the leaf extract of Panax ginseng Meyer (P.g AuNPs) exert anti-inflammatory effects through inhibition of downstream NF-κB activation in macrophages. We found that P.g AuNPs reduced the expression of the inflammatory mediators including nitric oxide (NO), prostaglandin E2 (PEG2), interleukin (IL)-6, tumor necrosis factor-α (TNF-α) was attenuated by P.g AuNPs. Furthermore, P.g AuNPs suppressed lipopolysaccharide (LPS)-induced activation of NF-κB signaling pathway via p38 mitogen-activated protein kinase (MAPK) in RAW 264.7 cells. Taken together, our results suggest that P.g AuNPs can be utilized as a novel therapeutic agent for the prevention and cure of inflammation.
a Department of Oriental Medicinal Biotechnology, College of Life Sciences , Kyung Hee University , Yongin , Republic of Korea.|b Graduate School of Biotechnology and Ginseng Bank, College of Life Sciences , Kyung Hee University , Yongin , Republic of Korea.
Sungeun
S
Ahn
a Department of Oriental Medicinal Biotechnology, College of Life Sciences , Kyung Hee University , Yongin , Republic of Korea.
Priyanka
P
Singh
a Department of Oriental Medicinal Biotechnology, College of Life Sciences , Kyung Hee University , Yongin , Republic of Korea.
Verónica
V
Castro-Aceituno
b Graduate School of Biotechnology and Ginseng Bank, College of Life Sciences , Kyung Hee University , Yongin , Republic of Korea.
Shakina
S
Yesmin Simu
a Department of Oriental Medicinal Biotechnology, College of Life Sciences , Kyung Hee University , Yongin , Republic of Korea.
Yu-Jin
YJ
Kim
b Graduate School of Biotechnology and Ginseng Bank, College of Life Sciences , Kyung Hee University , Yongin , Republic of Korea.
Ramya
R
Mathiyalagan
a Department of Oriental Medicinal Biotechnology, College of Life Sciences , Kyung Hee University , Yongin , Republic of Korea.|b Graduate School of Biotechnology and Ginseng Bank, College of Life Sciences , Kyung Hee University , Yongin , Republic of Korea.
Deok-Chun
DC
Yang
D000818:Animals; D002460:Cell Line; D006046:Gold / Q000737:chemistry / Q000494:pharmacology; D018836:Inflammation Mediators / Q000378:metabolism*; D020935:MAP Kinase Signaling System / Q000187:drug effects; D008264:Macrophages / Q000378:metabolism*; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism*; D005894:Panax / Q000737:chemistry*; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
D018836:Inflammation Mediators; D016328:NF-kappa B; D006046:Gold; D048051:p38 Mitogen-Activated Protein Kinases
Inflammation; NF-κB; P. ginseng; gold nanoparticles; green synthesis