Rheological Properties of Calcium Hydroxylapatite With Integral Lidocaine.
BACKGROUND
Calcium hydroxylapatite with integral lidocaine, CaHA (+), received FDA approval in 2015 and CE mark approval in 2016. This formulation has been associated with significant pain reduction compared to CaHA. In a previous rheometry study, CaHA without lidocaine demonstrated higher viscosity and elasticity when compared with hyaluronic acid fillers.


OBJECTIVE
To compare the rheological properties of CaHA (+) lidocaine to CaHA without lidocaine and to compare the rheological measures of CaHA (+) to 5 cross-linked hyaluronic acid (HA) fillers with integral 0.3% lidocaine.<br/>


METHODS
The rheological properties of complex viscosity (&eta;*) and elastic modulus (G') were measured for 2 types of CaHA fillers [CaHA without lidocaine and CaHA (+) with integral 0.3% lidocaine] and 5 HA fillers using an oscillation frequency sweep at a sheer stress of 5 pascal tau (Pa) and an interpolation of 0.7 Hz.<br/>


RESULTS
CaHA with and without integral lidocaine demonstrate similar &eta;* and G' measurements. CaHA with and without integral lidocaine demonstrates higher &eta;* and G' compared with HA fillers with integral lidocaine.<br/>


CONCLUSIONS
CaHA with integral lidocaine has a similar rheological profile to CaHA without lidocaine: the highest &eta;* and G' compared with available HA fillers with integral lidocaine. <br /><br /> <em>J Drugs Dermatol.</em> 2016;15(9):1107-1110.
Melissa
M
Meland
Chris
C
Groppi
Z Paul
ZP
Lorenc
D001672:Biocompatible Materials / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D000067548:Dermal Fillers / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D006801:Humans; D008012:Lidocaine / Q000737:chemistry*; D012212:Rheology / Q000379:methods*
D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D000067548:Dermal Fillers; D017886:Durapatite; D008012:Lidocaine