Effects of Di-isononyl Phthalate on Neuropeptide Y Expression in Differentiating Human Neuronal Cells.
Neuropeptide Y (NPY) is an abundant neuropeptide in the mammalian brain important for behavioural consequences of stress and energy metabolism. We have addressed possible effects of the phthalate DiNP on NPY expression in human SH-SY5Y cells, a neuronal in vitro differentiation model. Pico- to nanomolar doses of DiNP and its metabolite MiNP resulted in decreased NPY mRNA and peptide expression in retinoid-differentiated cells. Thus, dys-regulated NPY may be an adverse outcome for exposure to low doses of DiNP in human beings.
Biomedical Sciences, Karlstad University, Karlstad, Sweden.
Filip
F
Rendel
Biomedical Sciences, Karlstad University, Karlstad, Sweden.
Christina Fjaeraa
CF
Alfredsson
Public Health Science, Department of Health Sciences, Faculty of Health, Science and Technology, Karlstad University, Karlstad, Sweden.|Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Carl-Gustaf
CG
Bornehag
Biomedical Sciences, Karlstad University, Karlstad, Sweden.
Birgitta E
BE
Sundström
Biomedical Sciences, Karlstad University, Karlstad, Sweden.
Eewa
E
Nånberg
D002454:Cell Differentiation; D045744:Cell Line, Tumor; D006801:Humans; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D009478:Neuropeptide Y / Q000378:metabolism*; D010795:Phthalic Acids / Q000494:pharmacology*; D012333:RNA, Messenger / Q000378:metabolism; D014212:Tretinoin / Q000494:pharmacology
D009478:Neuropeptide Y; D010795:Phthalic Acids; D012333:RNA, Messenger; C012125:diisononyl phthalate; D014212:Tretinoin