Antiurease and anti-oxidant activity of Vaccinium macrocarpon fruit.
The objective of present study was to evaluate the antiurease and anti-oxidant activity of Vaccinium macrocarpon fruit. The parent extract was ethanolic extract while its sub fractions were prepared in n-hexane, chloroform and n-butanol. The method based on scavenging activity and reduction capability of 1, 1-diphenyl-2-picrylhydrazyl radical (DPPH). N-butanol fraction was the most effective antioxidant with 87.0±1.15 activity but the activity was less than ascorbic acid i.e. 93.74±0.12. Highly significant urease inhibition was shown by crude ethanolic extract (71.00±0.2a) with IC50 (392.66±2.1) followed by aqueous fraction (68.00±0.5e) with IC50 (159.83±2.8). The results of crude ethanolic extract and aqueous extracts were highly significant (p<0.05) than standard Thiourea. Present study showed that Vaccinium macrocarpon exhibits potent antiurease and antioxidant activities.
Department of Eastern Medicine and Surgery, University College of Conventional Medicine, Islamia University of Bahawalpur, Bahawalpur, Pakistan.
Shabana
S
Noreen
Department of Eastern Medicine and Surgery, University College of Conventional Medicine, Islamia University of Bahawalpur, Bahawalpur, Pakistan.
Ghazala
G
Shaheen
Department of Eastern Medicine and Surgery, Faculty of Medical and Health Sciences, The University of Poonch, Rawalakot, Azad Kashmir, Pakistan.
Muhammad
M
Akram
Directorate of Medical Sciences, GC University, Faisalabad, Pakistan.
Abid
A
Rashid
Department of Eastern Medicine and Surgery, Directorate of Medical Sciences, GC University, Faisalabad, Pakistan.
Syed Muhammad Ali
SM
Shah
D000975:Antioxidants / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry; D006801:Humans; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D014510:Urease / Q000037:antagonists & inhibitors*; D029799:Vaccinium macrocarpon / Q000737:chemistry*
D000975:Antioxidants; D001713:Biphenyl Compounds; D004791:Enzyme Inhibitors; D016166:Free Radical Scavengers; D010851:Picrates; D010936:Plant Extracts; C004931:1,1-diphenyl-2-picrylhydrazyl; D014510:Urease