Immunological battlefield in gastric cancer and role of immunotherapies.
Like the wars predating the First World War where human foot soldiers were deemed tools in the battlefield against an enemy, so too are the host immune cells of a patient battling a malignant gastric cancer. Indeed, the tumour microenvironment resembles a battlefield, where the patient's immune cells are the defence against invading tumour cells. However, the relationship between different immune components of the host response to cancer is more complex than an "us against them" model. Components of the immune system inadvertently work against the interests of the host and become pro-tumourigenic while other components soldier on against the common enemy - the tumour cell.
Minyu Wang, Rita A Busuttil, Alex Boussioutas, Cancer Genetics and Genomics Laboratory, Peter MacCallum Cancer Centre, East Melbourne 3002, Victoria, Australia.
Minyu
M
Wang
Minyu Wang, Rita A Busuttil, Alex Boussioutas, Cancer Genetics and Genomics Laboratory, Peter MacCallum Cancer Centre, East Melbourne 3002, Victoria, Australia.
Rita A
RA
Busuttil
Minyu Wang, Rita A Busuttil, Alex Boussioutas, Cancer Genetics and Genomics Laboratory, Peter MacCallum Cancer Centre, East Melbourne 3002, Victoria, Australia.
Sharon
S
Pattison
Minyu Wang, Rita A Busuttil, Alex Boussioutas, Cancer Genetics and Genomics Laboratory, Peter MacCallum Cancer Centre, East Melbourne 3002, Victoria, Australia.
Paul J
PJ
Neeson
Minyu Wang, Rita A Busuttil, Alex Boussioutas, Cancer Genetics and Genomics Laboratory, Peter MacCallum Cancer Centre, East Melbourne 3002, Victoria, Australia.
Alex
A
Boussioutas
D000230:Adenocarcinoma / Q000276:immunology* / Q000628:therapy; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D006801:Humans; D007167:Immunotherapy; D013274:Stomach Neoplasms / Q000276:immunology* / Q000628:therapy; D019139:Tumor Escape / Q000276:immunology*; D059016:Tumor Microenvironment / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents
Gastric cancer; Immune; Immune therapy; Immunology; Tumour microenvironment