Association between coronary microvascular function and the vasa vasorum in patients with early coronary artery disease.
The vasa vasorum (VV) plays a role in the initial phase of atherosclerosis, and abnormalities in microvascular function may be sensitive measures of the early development of atherosclerosis. The current study was designed to access the association between coronary microvascular function and VV density in patients undergoing cardiac catheterization.



Twenty-four patients with early coronary artery disease underwent endothelium-dependent (coronary blood flow, CBF) and endothelium-independent (coronary flow velocity reserve, CFVR) coronary microvascular function testing, and optical coherence tomography (OCT) imaging of the left anterior descending coronary artery (LAD). Using an intracoronary Doppler guidewire, CBF was examined by evaluating changes in blood flow in response to acetylcholine and CFVR in response to adenosine. VV density (VV volume/vessel volume × 100, %VV) of the proximal 10 mm of the LAD was quantified by OCT.



The median values (Q1, Q3) of CFVR, % changes in CBF in response to acetylcholine, and the %VV were 2.70 (2.30, 2.90), -16.82 (-42.34, 54.52), and 2.62 (2.35, 3.35), respectively. %VV correlated inversely with CBF (r = -0.614, p = 0.001) and directly with CFVR (r = 0.423, p = 0.040). Multivariate analysis showed that only %VV was significantly correlated with CBF and the association was independent of other clinical variables, Framingham risk score, body mass index, and a family history of coronary heart disease.



This study demonstrates that VV density has negative correlation with endothelium-dependent microvascular function in patients with early coronary atherosclerosis. These observations link adventitial VV structure and function to microvascular dysfunction in early coronary atherosclerosis.
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA; Division of Cardiovascular Disease, Hallym University Medical Center, Anyang, South Korea.
Kyoung-Ha
KH
Park
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
Tao
T
Sun
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
Felipe
F
Diez-Delhoyo
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
Zhi
Z
Liu
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
Shi-Wei
SW
Yang
Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
Ryan J
RJ
Lennon
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
Joerg
J
Herrmann
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
Rajiv
R
Gulati
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
Martin
M
Rodriguez-Porcel
Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Lilach O
LO
Lerman
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA. Electronic address: lerman.amir@mayo.edu.
Amir
A
Lerman
D063194:Adventitia / Q000503:physiopathology; D000368:Aged; D050197:Atherosclerosis / Q000503:physiopathology; D001783:Blood Flow Velocity; D003324:Coronary Artery Disease / Q000097:blood* / Q000473:pathology*; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000473:pathology*; D004730:Endothelium, Vascular / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D041623:Tomography, Optical Coherence; D014651:Vasa Vasorum / Q000473:pathology*
Microvascular function; Optical coherence tomography; Vasa vasorum