[Expression of autoantibody against the M2-muscarinic receptor in patients with severe preeclampsia].
OBJECTIVE
To test the expression of autoantibody against the M2-muscarinic receptor in patients with severe preeclampsia.


METHODS
A case-control study, including 78 patients with severe preeclampsia and 78 women with normal pregnancy in Department of Gynaecology and Obstetrics of Capital Medical University affiliated Beijing Chao-Yang Hospital from Jan, 2013 to Jan, 2015, were conducted, and 60 non-pregnant women were served as a control group. ELISA protocol was used to test serum autoantibody against the M2-muscarinic receptor. The clinical significance of the autoantibody against the M2-muscarinic receptor among women with severe preeclampsia was estimated.


RESULTS
Autoantibody against the M2-muscarinic receptor were positive in 32.1% (25/78) of patients with severe preeclampsia, in 10.3% (8/78, P<0.05) of normal pregnant women and in 8.3% (5/60, P<0.05) of non-pregnant controls. The concentration of creatine kinase in patients with severe preeclampsia and normal pregnant women were (101.49±142.75) and (57.94±31.64) U/L, respectively. Mask difference exist between the severe preeclampsia group and the normal pregnancy group (P<0.05).


CONCLUSIONS
The expression of autoantibody against the M2-muscarinic receptor in patients with severe preeclampsia is elevated significantly, which is associated with severe preeclampsia. However, its etiological role needs further to be investigated.
Department of Gynaecology and Obstetrics, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
Hao
H
Liu
Department of Gynaecology and Obstetrics, People's Hospital of Kelamayi, Karamay Xinjiang 834000, China.
Jing
J
Yang
Department of Gynaecology and Obstetrics, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
Lei
L
Zhu
Department of Gynaecology and Obstetrics, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
Yanfang
Y
Li
D001323:Autoantibodies; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia; D011247:Pregnancy; D043585:Receptor, Muscarinic M2; D012720:Severity of Illness Index
D001323:Autoantibodies; D043585:Receptor, Muscarinic M2