Manganese(I)-Catalyzed C-H Activation: The Key Role of a 7-Membered Manganacycle in H-Transfer and Reductive Elimination.
Manganese-catalyzed C-H bond activation chemistry is emerging as a powerful and complementary method for molecular functionalization. A highly reactive seven-membered Mn(I) intermediate is detected and characterized that is effective for H-transfer or reductive elimination to deliver alkenylated or pyridinium products, respectively. The two pathways are determined at Mn(I) by judicious choice of an electron-deficient 2-pyrone substrate containing a 2-pyridyl directing group, which undergoes regioselective C-H bond activation, serving as a valuable system for probing the mechanistic features of Mn C-H bond activation chemistry.
Department of Chemistry, University of York, York, YO10 5DD, UK.
Nasiru P
NP
Yahaya
Department of Chemistry, University of York, York, YO10 5DD, UK.
Kate M
KM
Appleby
Department of Chemistry, University of York, York, YO10 5DD, UK.
Magdalene
M
Teh
Department of Chemistry, University of York, York, YO10 5DD, UK.
Conrad
C
Wagner
Department of Chemistry, University of York, York, YO10 5DD, UK.
Erik
E
Troschke
Department of Chemistry, University of York, York, YO10 5DD, UK.
Joshua T W
JT
Bray
Department of Chemistry, University of York, York, YO10 5DD, UK.
Simon B
SB
Duckett
Department of Chemistry, University of York, York, YO10 5DD, UK.
L Anders
LA
Hammarback
Department of Chemistry, University of York, York, YO10 5DD, UK.
Jonathan S
JS
Ward
Department of Chemistry, University of York, York, YO10 5DD, UK.
Jessica
J
Milani
Department of Chemistry, University of York, York, YO10 5DD, UK.
Natalie E
NE
Pridmore
Department of Chemistry, University of York, York, YO10 5DD, UK.
Adrian C
AC
Whitwood
Department of Chemistry, University of York, York, YO10 5DD, UK. jason.lynam@york.ac.uk.
Jason M
JM
Lynam
Department of Chemistry, University of York, York, YO10 5DD, UK. ian.fairlamb@york.ac.uk.
Ian J S
0000-0002-7555-2761
IJ
Fairlamb
C−H activation; catalysis; functionalization; manganese; sustainability