Protocol for meta-analysis of temperature reduction in animal models of cardiac arrest.
Targeted temperature management (TTM) of 32-34 °C has been the standard treatment for out-of-hospital cardiac arrest since clinical trials in 2002 showed benefits to survival and neurological outcome. Recently, this treatment has been challenged by another clinical trial showing no difference in outcome between TTM of 33 °C and 36 °C. This protocol describes the methodology for a meta-analysis detailing temperature-reducing interventions to treat global ischaemia in animal models. By combining relevant data sets in the literature, we will explore the experimental evidence for TTM. Our aims are to explain possible translational gaps and provide methodological considerations for future experimental research and clinical trials.
Department of Experimental Medical Science Experimental Neuroinflammation Laboratory Lund Sweden.
H
H
Olai
Department of Experimental Medical Science Experimental Neuroinflammation Laboratory Lund Sweden.
G
G
Thornéus
Department of Experimental Medical Science Experimental Neuroinflammation Laboratory Lund Sweden.
H
H
Watson
Centre for Clinical Brain Sciences University of Edinburgh Edinburgh UK.
M R
MR
Macleod
Department of Anesthesia and Intensive Care Skåne University Hospital Lund Sweden; Department of Clinical Sciences Lund University Lund Sweden.
H
H
Friberg
Department of Critical Care, Anaesthesia and Pain Medicine University of Edinburgh Edinburgh UK; Intensive Care and Anaesthesia Western General Hospital Edinburgh UK.
J
J
Rhodes
Department of Clinical Sciences Lund University Lund Sweden; Department of Anaesthesia and Intensive Care Helsingborg Hospital Helsingborg Sweden.
N
N
Nielsen
Department of Clinical Sciences Lund University Lund Sweden; Department of Neurology Skåne University Hospital Lund Sweden.
T
T
Cronberg
Department of Experimental Medical Science Experimental Neuroinflammation Laboratory Lund Sweden.
T
T
Deierborg
animals; cardiac arrest; global ischaemia; hypothermia; meta‐analysis; temperature management