Phenotypic and Genetic Correlations Between the Lobar Segments of the Inferior Fronto-occipital Fasciculus and Attention.
Attention deficits may present dysfunctions in any one or two components of attention (alerting, orienting, and executive control (EC)). However, these various forms of attention deficits generally have abnormal microstructure integrity of inferior fronto-occipital fasciculus (IFOF). In this work, we aim to deeply explore: (1) associations between microstructure integrities of IFOF (including frontal, parietal, temporal, occipital, and insular segments) and attention by means of structural equation models and multiple regression analyses; (2) genetic/environmental effects on IFOF, attention, and their correlations using bivariate genetic analysis. EC function was attributed to the fractional anisotropy (FA) of left (correlation was driven by genetic and environmental factors) and right IFOF (correlation was driven by environmental factors), especially to left frontal part and right occipital part (correlation was driven by genetic factors). Alerting was associated with FA in parietal and insular parts of left IFOF. No significant correlation was found between orienting and IFOF. This study revealed the advantages of lobar-segmental analysis in structure-function correlation study and provided the anatomical basis for kinds of attention deficits. The common genetic/environmental factors implicated in the certain correlations suggested the common physiological mechanisms for two traits, which should promote the discovery of single-nucleotide polymorphisms affecting IFOF and attention.
Research Center for Sectional Imaging Anatomy, Shandong Provincial Key Laboratory of Mental Disorders, Shandong University School of Medicine, 44 Wen-hua Xi Road, 250012 Jinan, Shandong, China.|Laboratory of Neuro Imaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA.
Yuan
Y
Leng
Laboratory of Neuro Imaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA.
Yonggang
Y
Shi
Research Center for Sectional Imaging Anatomy, Shandong Provincial Key Laboratory of Mental Disorders, Shandong University School of Medicine, 44 Wen-hua Xi Road, 250012 Jinan, Shandong, China.
Qiaowen
Q
Yu
Laboratory of Neuro Imaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA.
John Darrell
JD
Van Horn
Research Center for Sectional Imaging Anatomy, Shandong Provincial Key Laboratory of Mental Disorders, Shandong University School of Medicine, 44 Wen-hua Xi Road, 250012 Jinan, Shandong, China.
Haiyan
H
Tang
Laboratory of Neuro Imaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA.
Junning
J
Li
Department of Radiology, Affiliated Hospital of Medical College, Qingdao University, 266003 Qingdao, Shandong, China.
Wenjian
W
Xu
Research Center for Sectional Imaging Anatomy, Shandong Provincial Key Laboratory of Mental Disorders, Shandong University School of Medicine, 44 Wen-hua Xi Road, 250012 Jinan, Shandong, China.
Xinting
X
Ge
Research Center for Sectional Imaging Anatomy, Shandong Provincial Key Laboratory of Mental Disorders, Shandong University School of Medicine, 44 Wen-hua Xi Road, 250012 Jinan, Shandong, China.
Yuchun
Y
Tang
Department of Radiology, Affiliated Hospital of Medical College, Qingdao University, 266003 Qingdao, Shandong, China.
Yan
Y
Han
Department of Epidemiology, Qingdao Municipal Center for Disease Control and Prevention, 266033 Qingdao, Shandong, China.
Dong
D
Zhang
Research Center for Sectional Imaging Anatomy, Shandong Provincial Key Laboratory of Mental Disorders, Shandong University School of Medicine, 44 Wen-hua Xi Road, 250012 Jinan, Shandong, China.
Min
M
Xiao
Department of Epidemiology, Qingdao Municipal Center for Disease Control and Prevention, 266033 Qingdao, Shandong, China.
Huaqiang
H
Zhang
Department of Epidemiology, Qingdao Municipal Center for Disease Control and Prevention, 266033 Qingdao, Shandong, China.
Zengchang
Z
Pang
Laboratory of Neuro Imaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA.
Arthur W
AW
Toga
Research Center for Sectional Imaging Anatomy, Shandong Provincial Key Laboratory of Mental Disorders, Shandong University School of Medicine, 44 Wen-hua Xi Road, 250012 Jinan, Shandong, China.
Shuwei
S
Liu
D000293:Adolescent; D000328:Adult; D001288:Attention / Q000502:physiology*; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics* / Q000473:pathology*; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D005625:Frontal Lobe / Q000033:anatomy & histology* / Q000502:physiology; D059647:Gene-Environment Interaction; D006801:Humans; D008297:Male; D009434:Neural Pathways; D009778:Occipital Lobe / Q000033:anatomy & histology* / Q000502:physiology; D066127:White Matter / Q000503:physiopathology*; D055815:Young Adult