Associations between Dietary Patterns, ADRβ2 Gln27Glu and ADRβ3 Trp64Arg with Regard to Serum Triglyceride Levels: J-MICC Study.
Interactions between dietary patterns and 2 β-adrenergic receptor (ADRβ) gene polymorphisms (ADRβ2 Gln27Glu and ADRβ3 Trp64Arg) were examined with regard to the effects on serum triglyceride levels. The cross-sectional study comprised 1720 men and women (aged 35-69 years) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Genotyping was conducted using a multiplex polymerase chain reaction-based invader assay. We used 46 items from a validated short food frequency questionnaire and examined major dietary patterns by factor analysis. We identified four dietary patterns: healthy, Western, seafood and bread patterns. There was no significant association between any dietary pattern and serum triglyceride levels. After a separate genotype-based analysis, significant interactions between ADRβ3 Trp64Arg genotype and the bread pattern (p for interaction = 0.01) were associated with serum triglyceride levels; specifically, after adjusting for confounding factors, Arg allele carriers with the bread pattern had lower serum triglycerides (p for trend = 0.01). However, the Trp/Trp homozygous subjects with the bread pattern showed no association with serum triglycerides (p for trend = 0.55). Interactions between other dietary patterns and ADRβ polymorphisms were not significant for serum triglyceride levels. Our findings suggest that ADRβ3 polymorphism modifies the effects of the bread pattern on triglyceride levels.
Department of Public Health, Showa University School of Medicine, Tokyo 142-8555, Japan. nanrih@med.showa-u.ac.jp.
Hinako
H
Nanri
Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga 849-8501, Japan. ynishida@cc.saga-u.ac.jp.
Yuichiro
Y
Nishida
St. Mary's College Faculty of Nursing, Kurume 830-8558, Japan. k-nakamura@st-mary.ac.jp.
Kazuyo
K
Nakamura
Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga 849-8501, Japan. tanakake@post.saga-med.ac.jp.
Keitaro
K
Tanaka
Department of Preventive Medicine Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan. mnaito@med.nagoya-u.ac.jp.
Mariko
M
Naito
Department of Nutritional Sciences, Faculty of Health and Welfare, Seinan Jo Gakuin University, Fukuoka 803-0835, Japan. yinguang@seinan-jo.ac.jp.
Guang
G
Yin
Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan. nhamajim@med.nagoya-u.ac.jp.
Nobuyuki
N
Hamajima
Department of Health Science, Shiga University of Medical Science, Ohtsu 520-2192, Japan. takasima@belle.shiga-med.ac.jp.
Naoyuki
N
Takashima
Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan. ssuzuki@med.nagoya-cu.ac.jp.
Sadao
S
Suzuki
Graduate School of Medical and Dental Sciences, Department of International Island and Community Medicine, Kagoshima University, Kagoshima 890-8520, Japan. yora@m.kufm.kagoshima-u.ac.jp.
Yora
Y
Nindita
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. mkohno@intmed3.med.kyushu-u.ac.jp.
Michiko
M
Kohno
Department of Preventive Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima 770-8503, Japan. uemura.hirokazu@tokushima-u.ac.jp.
Hirokazu
H
Uemura
Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto 602-8566, Japan. tkoyama@koto.kpu-m.ac.jp.
Teruhide
T
Koyama
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan. shosono@aichi-cc.jp.
Satoyo
S
Hosono
Division of Cancer Registry, Prevention and Epidemiology, Chiba Cancer Center, Chiba 260-8717, Japan. hmikami@chiba-cc.jp.
Haruo
H
Mikami
Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan. michiaki.kubo@riken.jp.
Michiaki
M
Kubo
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan. tanaka_sec@aichi-cc.jp.
Hideo
H
Tanaka
D000328:Adult; D000368:Aged; D000483:Alleles; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004032:Diet; D005260:Female; D060005:Genotyping Techniques; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007564:Japan; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015596:Nutrition Assessment; D011110:Polymorphism, Genetic; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics*; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D014280:Triglycerides / Q000097:blood*
C553443:ADRB2 protein, human; C568534:ADRB3 protein, human; D018343:Receptors, Adrenergic, beta-2; D022702:Receptors, Adrenergic, beta-3; D014280:Triglycerides
dietary pattern; factor analysis; polymorphism; triglyceride; β-adrenergic receptor (ADRβ)