Role of Inflammation and Oxidative Stress in the Pathology of Ageing in COPD: Potential Therapeutic Interventions.
Ageing is defined as a progressive decline of homeostasis that occurs after the reproductive phase of life is complete, which is thought to arise because of impaired DNA repair following damage. This leads to an increased risk of disease or death. Ageing is one of the most important risk factors for most chronic diseases. Chronic obstructive pulmonary disease (COPD) represents an important component of the increasingly prevalent multiple chronic debilitating diseases that are a major cause of morbidity and mortality, particularly in the elderly. There is increasing evidence that the pathogenesis of COPD is linked to an accelerated ageing process. This review discusses the evidence supporting a number of mechanisms, including oxidative stress and ageing, in the pathogenesis of COPD. Greater understanding of these mechanisms leads to novel therapeutic interventions targeted at this heterogeneous disease.
a MRC Centre for Inflammation Research, Queens Medical Research Institute , 47 little France Crescent Edinburgh, United Kingdom.
Gourab
G
Choudhury
a MRC Centre for Inflammation Research, Queens Medical Research Institute , 47 little France Crescent Edinburgh, United Kingdom.
William
W
MacNee
D000375:Aging / Q000502:physiology*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use*; D017209:Apoptosis; D001343:Autophagy; D016922:Cellular Senescence; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000235:genetics; D008168:Lung / Q000473:pathology; D008928:Mitochondria / Q000502:physiology; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy* / Q000209:etiology*; D026361:Reactive Nitrogen Species / Q000633:toxicity; D017382:Reactive Oxygen Species / Q000633:toxicity; D037761:Sirtuins / Q000378:metabolism; D059506:Telomere Shortening; D056811:Unfolded Protein Response
D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D017127:Glycation End Products, Advanced; D016328:NF-kappa B; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D037761:Sirtuins
Chronic obstructive pulmonary disease; inflammation; novel therapies; oxidative stress; senescence