Bioactive Lupane and Hopane Triterpenes from Lepisanthes senegalensis.
Two lupane and hopane caffeates (1and4) and two hopane coumarates (2and3) along with eight known compounds (5-12) were isolated from stems and roots ofLepisanthes senegalensis. Their structures were established on the basis of spectroscopic techniques. The structure of compound2was confirmed by single-crystal X-ray diffraction analysis. Triterpenes1and4-6showed cytotoxicity against the NCI-H187 cell line with IC50values of 31.5, 28.5, 16.2, and 4.0 µM, respectively. However, these compounds also showed cytotoxicity against Vero cells, with IC50values of 75.5, 16.6, 8.9, and 5.0 µM, respectively. In addition, compound6exhibited a moderate antimalarial activity with an IC50value of 4.5 µM.
Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
Pornwimon
P
Lomchid
Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
Pitak
P
Nasomjai
Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
Somdej
S
Kanokmedhakul
Materials Chemistry Research Center, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
Jaursup
J
Boonmak
Materials Chemistry Research Center, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
Sujittra
S
Youngme
Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
Kwanjai
K
Kanokmedhakul
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D045744:Cell Line, Tumor; D002522:Chlorocebus aethiops; D018360:Crystallography, X-Ray / Q000379:methods; D006801:Humans; D020128:Inhibitory Concentration 50; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D029631:Sapindaceae / Q000737:chemistry*; D055752:Small Cell Lung Carcinoma / Q000188:drug therapy; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014709:Vero Cells; D014961:X-Ray Diffraction / Q000379:methods; D053978:Pentacyclic Triterpenes
D000962:Antimalarials; D010936:Plant Extracts; D014315:Triterpenes; C480546:lupane; D053978:Pentacyclic Triterpenes; C025206:hopane