Large artery stiffness is associated with gamma-glutamyltransferase in young, healthy adults: The African-PREDICT study.
Increased arterial stiffness is linked to cardiovascular disease development, particularly in black populations. Since detrimental health behaviors in young adults may affect arterial stiffness, we determined whether arterial stiffness associates with specific health behaviors, and whether it is more pronounced in young healthy black compared to white adults. We included 373 participants (49% black, 42% men) aged 20-30 years. Mean arterial pressure was higher for blacks than whites (P < .001), but carotid-femoral pulse wave velocity was similar (6.37 vs. 6.36 m/s; P = .89) after adjustment for mean arterial pressure. The black group had higher gamma-glutamyltransferase (GGT) (P < .001), cotinine, reactive oxygen species, interleukin-6, and monocyte-chemoattractant protein-1 (all P ≤ .017). Pulse wave velocity related positively and independently to GGT in both groups before and after multiple adjustments (both β = 0.15; P ≤ .049). Blacks had an unfavorable vascular profile and higher GGT, possibly indicating a higher vulnerability to cardiovascular disease development, including changes in arterial stiffness. However, this observation needs confirmation.
Hypertension in Africa Research Team (HART), Department of Health Sciences, North-West University, Potchefstroom, South Africa.
Melissa
M
Maritz
Hypertension in Africa Research Team (HART), Department of Health Sciences, North-West University, Potchefstroom, South Africa. Electronic address: carla.fourie@nwu.ac.za.
Carla M T
CM
Fourie
Hypertension in Africa Research Team (HART), Department of Health Sciences, North-West University, Potchefstroom, South Africa.
Johannes M
JM
Van Rooyen
Physical activity, Sport and Recreation Research Focus Area, Department of Health Sciences, North-West University, Potchefstroom, South Africa.
Sarah J
SJ
Moss
Hypertension in Africa Research Team (HART), Department of Health Sciences, North-West University, Potchefstroom, South Africa; MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa.
Aletta E
AE
Schutte
D000328:Adult; D000349:Africa / Q000453:epidemiology; D001158:Arteries / Q000502:physiology; D015415:Biomarkers / Q000097:blood; D044383:Black People; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology; D018932:Chemokine CCL2 / Q000097:blood*; D003367:Cotinine / Q000097:blood*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D063177:Pulse Wave Analysis; D012307:Risk Factors; D059289:Vascular Stiffness; D044465:White People; D055815:Young Adult; D005723:gamma-Glutamyltransferase / Q000097:blood*
D015415:Biomarkers; C111835:CCL2 protein, human; D018932:Chemokine CCL2; C508600:IL6 protein, human; D015850:Interleukin-6; D005723:gamma-Glutamyltransferase; D003367:Cotinine
Ethnicity; health behavior; pulse wave velocity; young adults