Trauma as a Cause for Hepatopathy in Newborn Göttingen Minipigs.
Routine husbandry procedures during animal toxicity studies can result in incidental pathological changes. We report on trauma-induced hepatopathy in newborn Göttingen minipigs. Sixty-four neonatal minipigs were allocated to 13- and 26-week treatment arms. There was a 4-week recovery period for both arms. The animals were divided into 2 treatment groups and a vehicle group and were dosed 3 times daily by direct oral administration using a syringe. During the feeding procedure in the first weeks, the animals had to be handled firmly. After 13 weeks, randomly distributed foci of degeneration/necrosis and focal congestion and/or hemorrhage were found in the livers of several animals from all groups. Reduced incidence and severity were evident in the recovery phase, and the lesions were absent after 26 weeks. These changes were considered as related to the manual handling of the animals. Knowledge of these findings is crucial for interpretation of studies utilizing newborn minipigs.
1 Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Yuval
Y
Ramot
2 AnaPath GmbH, Oberbuchsiten, Switzerland.
Klaus
K
Weber
3 Centro de Cirugía de Mínima Invasión (CCMI), Caceres, Spain.
Beatriz
B
Moreno Lobato
3 Centro de Cirugía de Mínima Invasión (CCMI), Caceres, Spain.
Francisco Miguel
FM
Sánchez-Margallo
3 Centro de Cirugía de Mínima Invasión (CCMI), Caceres, Spain.
José Francisco
JF
Guillén Caro
3 Centro de Cirugía de Mínima Invasión (CCMI), Caceres, Spain.
Luis
L
Dávila Gómez
4 Roni Shabat CCMI Israel Ltd., Nazareth, Israel.
Roni
R
Shabat
5 Sackler School of Medicine, Tel Aviv University, Timrat, Israel.
Abraham
A
Nyska
D000822:Animal Husbandry / Q000592:standards*; D000818:Animals; D000831:Animals, Newborn / Q000293:injuries*; D005260:Female; D008099:Liver / Q000293:injuries* / Q000473:pathology; D008297:Male; D012149:Restraint, Physical / Q000009:adverse effects*; D013552:Swine / Q000293:injuries*; D013556:Swine, Miniature / Q000293:injuries*; D018675:Toxicity Tests / Q000379:methods*
Göttingen; hepatopathy; incidental finding; liver; minipigs; trauma