Weight loss improves biomarkers endothelial function and systemic inflammation in obese postmenopausal Saudi women.
BACKGROUND
Although postmenopausal associated disorders are important public health problems worldwide, to date limited studies evaluated the endothelial function and systemic inflammation response to weight loss in obese postmenopausal women.


OBJECTIVE
This study was done to evaluate the endothelial function and systemic inflammation response to weight loss in obese postmenopausal Saudi women.


METHODS
Eighty postmenopausal obese Saudi women (mean age 52.64±6.13 year) participated in two groups: Group (A) received aerobic exercise on treadmill and diet whereas, group (B) received no intervention. Markers of inflammation and endothelial function were measured before and after 3 months at the end of the study.


RESULTS
The values of body mass index(BMI), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), inter-cellular adhesion molecule (ICAM-1), vascular cell adhesion molecule (VCAM-1) and plasminogen activator inhibitor-1 activity (PAI-1:Ac) were significantly decreased in group (A), while changes were not significant in group (B). Also, there were significant differences between mean levels of the investigated parameters in group (A) and group (B) after treatment.


CONCLUSIONS
Weight loss ameliorates inflammatory cytokines and markers of endothelial function in obese postmenopausal Saudi women.
Department of Physical Therapy, Faculty of Applied Medical Sciences, King Abdulaziz University.
Shehab Mahmoud
SM
Abd El-Kader
Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University.
Mohammed H
MH
Saiem Al-Dahr
D000886:Anthropometry; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D016207:Cytokines / Q000097:blood*; D003906:Developing Countries; D004038:Diet, Reducing; D004727:Endothelium / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000534:rehabilitation*; D017698:Postmenopause; D012016:Reference Values; D012529:Saudi Arabia; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood* / Q000503:physiopathology; D016896:Treatment Outcome; D015431:Weight Loss
D015415:Biomarkers; D016207:Cytokines
Menopause; cytokines; diet; endothelial function; exercise