Metal-Free Synthesis of Highly Substituted Pyridines by Formal [2+2+2] Cycloaddition under Mild Conditions.
The synthesis of pyridines through direct intermolecular cycloaddition of alkynes and nitriles is a contemporary challenge in organic synthesis. A Brønsted acid mediated formal [2+2+2] cycloaddition of heteroalkynes and nitriles was developed that proceeds under mild conditions. This constitutes a modular approach to highly substituted pyridine cores.
University of Vienna, Institute of Organic Chemistry, Währinger Strasse 38, 1090, Vienna, Austria.
Lan-Gui
LG
Xie
University of Vienna, Institute of Organic Chemistry, Währinger Strasse 38, 1090, Vienna, Austria.
Saad
S
Shaaban
University of Vienna, Institute of Organic Chemistry, Währinger Strasse 38, 1090, Vienna, Austria.
Xiangyu
X
Chen
University of Vienna, Institute of Organic Chemistry, Währinger Strasse 38, 1090, Vienna, Austria. nuno.maulide@univie.ac.at.
Nuno
N
Maulide
alkynes; cycloaddition; heteroalkynes; nitriles; pyridines