Oral manifestations of lymphoma: a systematic review.
Lymphoma is a malignant disease with two forms: Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL). Non-Hodgkin's lymphoma is diagnosed in extranodal sites in 40% of cases, and the head and neck region is the second most affected, with an incidence of 11-33%, while HL has a very low incidence in extranodal sites (1-4%). The aim of this study was to identify the oral manifestations of lymphoma through a systematic literature review, which we conducted using the PubMed, Lilacs, Embase, and Cochrane Library databases. We found 1456 articles, from which we selected 73. Among the intraoral findings, the most frequent were ulcerations, pain, swelling, and tooth mobility, while the extraoral findings included facial asymmetry and cervical, submandibular, and submental lymphadenopathy. Among the few studies reporting imaging findings, the most cited lesions included hypodense lesions with diffuse boundaries, bone resorptions, and tooth displacements. The publications reviewed highlight gaps in the areas of early detection, diagnosis, and proper treatment.
Instituto Nacional de Câncer (INCA), Rio de Janeiro, Brazil.
Taísa Domingues Bernardes
TD
Silva
Library Section, Instituto Nacional de Câncer (INCA), Rio de Janeiro, Brazil.
Camila Belo Tavares
CB
Ferreira
Private practice.
Gustavo Boehmer
GB
Leite
Dentistry Section, Instituto Nacional de Câncer (INCA), Rio de Janeiro, Brazil.
José Roberto
JR
de Menezes Pontes
Clinical Research Division, Instituto Nacional de Câncer (INCA), Rua André Cavalcante, n 37, 2 andar, Rio de Janeiro, RJ CEP20231-050, Brazil.
Héliton S
HS
Antunes
dental care; lymphoma; oral cavity; oral manifestations