Nociceptive and Neuronal Evaluation of the Sciatic Nerve of Wistar Rats Subjected to Compression Injury and Treated with Resistive Exercise.
Background. To investigate the climb stairs resistance exercise on nociception and axonal regeneration in the sciatic nerve of rats. Methods. 24 Wistar rats were divided: control group (CG-no injury), exercise group (EG-no injury with physical exercise), lesion group (LG-injury, but without exercise), and treated group (LEG-injury and physical exercise). LG and LEG were subjected to sciatic nerve compression with hemostat. From the 3rd day after injury began treatment with exercise, and after 22 days occurs the removal of a nerve fragment for morphological analysis. Results. Regarding allodynia, CG obtained values less than EG (p = 0.012) and larger than LG and LEG (p < 0.001). Histological results showed that CG and EG had normal appearance, as LG and LEG showed up with large amounts of inflammatory infiltration, degeneration and disruption of nerve fibers, and reduction of the myelin sheath; however LEG presented some regenerated fibers. From the morphometric data there were significant differences, for nerve fiber diameter, comparing CG with LG and LEG and comparing axon diameter and the thickness of the myelin of the CG to others. Conclusion. Climb stairs resistance exercise was not effective to speed up the regenerative process of axons.
State University of Western Paraná (UNIOESTE), Universitaria Street, 2069, P.O. Box 711, 85819-110 Cascavel, PR, Brazil.
Juliana Sobral
JS
Antunes
State University of Western Paraná (UNIOESTE), Universitaria Street, 2069, P.O. Box 711, 85819-110 Cascavel, PR, Brazil.
Keli
K
Lovison
State University of Western Paraná (UNIOESTE), Universitaria Street, 2069, P.O. Box 711, 85819-110 Cascavel, PR, Brazil.
Jhenifer
J
Karvat
State University of Western Paraná (UNIOESTE), Universitaria Street, 2069, P.O. Box 711, 85819-110 Cascavel, PR, Brazil.
Ana Luiza
AL
Peretti
State University of Western Paraná (UNIOESTE), Universitaria Street, 2069, P.O. Box 711, 85819-110 Cascavel, PR, Brazil.
Lizyana
L
Vieira
State University of Western Paraná (UNIOESTE), Universitaria Street, 2069, P.O. Box 711, 85819-110 Cascavel, PR, Brazil.
Guilherme Hideaki
GH
Higuchi
State University of Western Paraná (UNIOESTE), Universitaria Street, 2069, P.O. Box 711, 85819-110 Cascavel, PR, Brazil.
Rose Meire Costa
0000-0002-5344-5076
RM
Brancalhão
State University of Western Paraná (UNIOESTE), Universitaria Street, 2069, P.O. Box 711, 85819-110 Cascavel, PR, Brazil.
Lucinéia de Fátima Chasko
Lde F
Ribeiro
State University of Western Paraná (UNIOESTE), Universitaria Street, 2069, P.O. Box 711, 85819-110 Cascavel, PR, Brazil.
Gladson Ricardo Flor
0000-0003-0565-2019
GR
Bertolini
D000704:Analysis of Variance; D000818:Animals; D001176:Arthrogryposis / Q000150:complications*; D001369:Axons / Q000473:pathology*; D004195:Disease Models, Animal; D005081:Exercise Therapy; D015417:Hereditary Sensory and Motor Neuropathy / Q000150:complications*; D006930:Hyperalgesia / Q000175:diagnosis / Q000209:etiology; D009412:Nerve Fibers / Q000473:pathology; D017288:Pain Threshold; D010805:Physical Conditioning, Animal; D026741:Physical Therapy Modalities; D051381:Rats; D017208:Rats, Wistar; D020426:Sciatic Neuropathy / Q000209:etiology / Q000473:pathology / Q000534:rehabilitation