Reducing the economic burden in management of Guillain-Barre syndrome using modified plasmapheresis.
BACKGROUND
Guillain-Barre syndrome (GBS) is an autoimmune acute inflammatory demyelinating polyneuropathy affecting the peripheral nervous system treated with high-dose immunoglobulin, physical therapy, or plasmapheresis. Immunoglobulins are expensive and even plasmapheresis might not be affordable to patients visiting government set-ups.


OBJECTIVE
This study was undertaken to emphasize the efficacy of plasmapheresis in treatment of adult GBS patients and to narrate methods of reducing the economic burden in the treatment of these patients using modified plasmapheresis.


METHODS
A study was conducted on 12 adult GBS patients at Sir Takhtasinhji General Hospital, Bhavnagar from July 2012 to July 2014. Patients were assessed on a 6-point disability scale. They were treated with plasmapheresis over 10 days with REF627 kit from Haemonetics Corporation Limited on MCS+ machine. Improvement was noted by the change in the disability scale score and expenses of various modes of treatment were also considered.


RESULTS
Seventy-five percent showed improvement at the end of the treatment. The cost of modified plasmapheresis was Rs. 8000/cycle, i.e., Rs. 40,000/patient.


CONCLUSIONS
Plasmapheresis along with proper supportive measures is a more cost-effective efficacious mode of therapy in adult patients of GBS. Further, modified plasmapheresis using REF627 kit and 6% hexastarch as replacement fluid on MCS+ apheresis machine reduces the cost of therapy for poor patients visiting government set-ups.
Department of Pathology, Government Medical College, Bhavnagar, Gujarat, India.
Rekha Ramaswamy
RR
Iyer
Department of Pathology, Government Medical College, Bhavnagar, Gujarat, India.
Pragnesh Hasmukhlal
PH
Shah
Department of Pathology, Government Medical College, Bhavnagar, Gujarat, India.
Sher Sankar K
SS
Roy
Department of Pathology, Government Medical College, Bhavnagar, Gujarat, India.
Sushil Kumar Kundanlal
SK
Suri
Economical; Guillain–Barre syndrome; plasmapheresis