Recurrent Fungal Keratitis and Blepharitis Caused by Aspergillus flavus.
Aspergillus species produces a wide spectrum of fungal diseases like endophthalmitis and fungal keratitis ophthalmologically, but there has been no report about blepharitis caused by Aspergilus flavus to date. Herein, we report a 61-year-old ethnic Han Taiwanese male who had suffered from pain with burning and foreign body sensation after an insect bite on his left eye. Specimens from bilateral eyelids suggested infection of A. flavus, whereas corneal scraping showed the presence of Gram-negative bacteria. He was admitted for treatment of infectious keratitis with topical antibiotic and antifungal eye drops. Two weeks after discharge, recurrent blepharitis and keratitis of A. flavus was diagnosed microbiologically. Another treatment course of antifungal agent was resumed in the following 6 months, without further significant symptoms in the following 2 years. Collectively, it is possible for A. flavus to induce concurrent keratitis and blepharitis, and combined treatment of keratitis as well as blepharitis is advocated for as long as 6 months to ensure no recurrence.
Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan.|Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua, Taiwan.
Chia-Yi
CY
Lee
Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan.
Yi-Ju
YJ
Ho
Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan.|Department of Medicine, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Chi-Chin
CC
Sun
Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan.|Department of Medicine, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Hsin-Chiung
HC
Lin
Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan.|Department of Medicine, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Ching-Hsi
CH
Hsiao
Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan.|Department of Medicine, Chang Gung University College of Medicine, Taoyuan, Taiwan.|Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou, Taiwan.
David Hui-Kang
DH
Ma
Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan.|Department of Medicine, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Chi-Chun
CC
Lai
Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan. mr3756@cgmh.org.tw.|Department of Medicine, Chang Gung University College of Medicine, Taoyuan, Taiwan.|Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou, Taiwan.
Hung-Chi
HC
Chen
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001231:Aspergillus flavus / Q000302:isolation & purification*; D001762:Blepharitis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D015821:Eye Infections, Fungal / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D005500:Follow-Up Studies; D006801:Humans; D007634:Keratitis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D010866:Natamycin / Q000627:therapeutic use; D013624:Taiwan; D013752:Tetracycline / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D010866:Natamycin; D013752:Tetracycline