Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand.
Delta/Notch-like EGF-related receptor (DNER) has been reported to act as a Notch ligand, despite lacking a Delta/Serrate/Lag (DSL) binding domain common to all other known ligands. The established Notch ligand Delta-like 1 (DLL1), but not DNER, activated Notch1 in a luciferase assay, prevented the differentiation of myoblasts through Notch signaling, and bound Notch-fc in a cell-based assay. DNER is not a Notch ligand and its true function remains unknown.
Department of Neurology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America.
Maxwell
http://orcid.org/0000-0001-9425-8587
M
Greene
Department of Neurology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America.
Yongjie
Y
Lai
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America.|Department of Pharmacology, University of Illinois, Chicago, United States of America.
Kostandin
K
Pajcini
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America.|Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut, United States of America.
Will
W
Bailis
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America.
Warren S
WS
Pear
Department of Neurology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America.
Eric
E
Lancaster
D002454:Cell Differentiation / Q000502:physiology; D002460:Cell Line; D057809:HEK293 Cells; D006801:Humans; D008024:Ligands; D032446:Myoblasts / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D051881:Receptor, Notch1 / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
C462501:DNER protein, human; D008024:Ligands; C497761:NOTCH1 protein, human; D009419:Nerve Tissue Proteins; D051881:Receptor, Notch1; D011956:Receptors, Cell Surface; D051880:Receptors, Notch