Efficacy of Dialkylcarbamoylchloride-Coated Dressing in Management of Colonized or Infected Neonatal and Pediatric Wounds.
BACKGROUND
Wound healing is a dynamic process that normally follows a predictable cascade of events. A common cause of delayed wound healing or wound dehiscence is increased colonization with microbes, often leading to infection. Infection may impede the healing process by inducing an undesirable inflammatory response. Systemic antibiotics and topical antiseptics are mainstays of treatment, but their adverse side effects and the potential for emergence of resistant microbial strains have led to a search for alternative approaches for control of bioburden.


METHODS
We describe two neonates and one 10-year-old girl who experienced delayed wound healing treated with a nonmedicated dressing that exploits bacterial cell-surface hydrophobic interactions via a dressing with a fatty acid (dialkylcarbamoylchloride [DACC]) coating. This dressing was used in a colonized, unstageable occipital pressure injuries, an infected stage 4 pressure injury over a vertebra, and a dehisced surgical sternal wound. Complete closure was achieved in all wounds within 2 to 4 weeks.


CONCLUSIONS
We employed a DACC-coated dressing that provides bacteriostatic activity without creating cytotoxicity or an inflammatory response.
Vita Boyar, MD, Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Cohen Children's Medical Center of New York, New Hyde Park, New York; and Hofstra North Shore-LIJ School of Medicine, Hempstead, New York.
Vita
V
Boyar
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001458:Bandages / Q000382:microbiology / Q000592:standards*; D002262:Carboxy-Lyases / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions / Q000187:drug effects; D007223:Infant; D013529:Surgical Wound Dehiscence / Q000188:drug therapy; D013530:Surgical Wound Infection / Q000188:drug therapy; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
D000900:Anti-Bacterial Agents; D002262:Carboxy-Lyases; C063519:2,2-dialkylglycine decarboxylase