Formulation, characterization, in vitro and in vivo evaluation of castor oil based self-nano emulsifying levosulpiride delivery systems.
BACKGROUND
Levosulpiride (LSP) is a hydrophobic benzamide derivative used in the treatment of schizophrenia. SNEDDS were extensively practiced for systemic delivery of poorly aqueous soluble drugs to achieve maximum bioavailability.


OBJECTIVE
The present study was focussed on the formulation, optimisation and evaluation of LSP SNEDDS using castor oil, for enhancement of drug absorption and bioavailability.


METHODS
Pseudo-ternary phase diagram was plotted to identify the range of SNEDDS components. Twenty formulations were designed, prepared and characterised by its particle size, zeta potential, viscosity, and stability. In vitro dissolution data modelling was performed. Microscopy, FTIR and in vivo bioavailability studies were conducted for optimum formulation. Results, discussion and conclusion: F18 containing castor oil, 0.9 mL; PEG 600, 1.36 mL and Tween 80, 2.74 mL was found to be optimum. The optimised formulation had shown uniform globule size, no interactions of LSP with SNEDDS components and higher pharmacokinetic parameters than that of commercial preparation.
a Bioprospecting Laboratory, School of Chemical and Biotechnology , SASTRA University , Thanjavur , India.
G
G
Poorani
b Department of Pharmaceutical Chemistry, Nirmala College of Pharmacy , Mangalagiri , India.
Spandana
S
Uppuluri
a Bioprospecting Laboratory, School of Chemical and Biotechnology , SASTRA University , Thanjavur , India.
Kiran Babu
KB
Uppuluri
D000818:Animals; D002368:Castor Oil / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D004353:Drug Evaluation, Preclinical; D004655:Emulsions; D008297:Male; D053758:Nanoparticles / Q000737:chemistry*; D051381:Rats; D013469:Sulpiride / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology
D004655:Emulsions; D013469:Sulpiride; D002368:Castor Oil; C078143:levosulpiride
Levosulpiride; SNEDDS; bioavailability; castor oil; dissolution modelling; optimisation; pseudo-ternary diagram