[Clinical and microbiological characteristics of complicated intra-abdominal infection in Colombia: a multicenter study].
BACKGROUND
Complicated community-acquired intra-abdominal infections (CA-cIAI) are a common cause of acute abdomen.


OBJECTIVE
To identify the clinical and microbiology profile of CA-cIAI in four Colombian hospitals.


METHODS
This is a prospective, descriptive study, between 08-2012 and 09-2014, including patients with CA-cIAI > 15 years. Data collected included: socio-demographic, clinical, diagnosis, and isolates of the first culture obtained aseptically during surgery with antimicrobial susceptibility.


RESULTS
192 patients were included, 62% men, median age 47.3 years. Co-morbidities were present in 38.4%, 13% had been hospitalized in the previous year 13%, and 9.4% had received antibiotics in the last 6 months; 44.3% were admitted for appendicitis, 17.7% for peritonitis and 16.7% for bowel perforation. CA-cIAI were assessed as moderate in 64.1% of the cases and were treated with ampicillin/sulbactam (SAM) and ertapenem. In 70.8% of cases a bacteria was isolated: 65.1% were gramnegative rods (80.0% Escherichia coli, 44.8% of them susceptible to pipercillin/tazobactam, 65.7% to SAM; 11.2 % were K.pneumoniae, 85% was susceptible for SAM; 16.7% were grampositive cocci (28.1% Streptococci viridans group). The median hospital stay was 7 days and 15.1% died.


CONCLUSIONS
E. coli, K. pneumoniae and S. viridans were the main organisms to consider in an empiric therapy for CA-cIAI and it is important to know the local epidemiology in order to choose the right antibiotic.
Universidad Pontificia Bolivariana, Medellín, Colombia, vallejomarta@yahoo.com.
Marta
M
Vallejo
Universidad Pontificia Bolivariana, Medellín, Colombia.
Diana P
DP
Cuesta
Hospital General de Medellín, Colombia.
Luz E
LE
Flórez
Centro Internacional de Entrenamiento e Investigaciones Médicas, Cali, Colombia.
Adriana
A
Correa
Hospital Universitario San Jorge, Pereira, Colombia.
Carmen E
CE
Llanos
Hospital Universitario San Jorge, Pereira, Colombia.
Berenice
B
Isaza
Fundación Santa Fe de Bogotá, Bogotá, Colombia.
Stella
S
Vanegas
Hospital Universitario Hernando Moncaleano Perdomo, Neiva, Colombia.
Johanna
J
Osorio
Hospital Universitario Hernando Moncaleano Perdomo, Neiva, Colombia.
Lucía
L
Casanova
Centro Internacional de Entrenamiento e Investigaciones Médicas, Cali, Colombia.
María V
MV
Villegas
D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use; D003105:Colombia / Q000453:epidemiology; D017714:Community-Acquired Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D005260:Female; D006090:Gram-Negative Bacteria / Q000302:isolation & purification*; D006094:Gram-Positive Bacteria / Q000302:isolation & purification*; D006801:Humans; D059413:Intraabdominal Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology*; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012016:Reference Values; D012307:Risk Factors; D012959:Socioeconomic Factors; D018709:Statistics, Nonparametric
D000890:Anti-Infective Agents