Investigation of oxidant and antioxidant levels in patients with acute stroke in the emergency service.
OBJECTIVE
In this study, we aimed to identify oxidative stress and the disruption in the oxidant-antioxidant balance in the acute phase of stroke and, therefore, to detect markers that will guide in the diagnosis and treatment of stroke.


METHODS
Eighty-six patients who were admitted to Antalya Training and Research Hospital Emergency Department between June 2013 and December 2013 and who were diagnosed as having stroke were enrolled in this study. The control group consisted of 40 healthy volunteers. Blood samples collected from all participants were screened for albumin, ischemic modified albumin (IMA), IMA/albumin ratio (IMAR), total antioxidant status, total oxidant status (TOS), and oxidative stress index (OSI).


RESULTS
Sixty (70%) patients were diagnosed as having acute cerebral infarction (ACI) and 26 (30%) as having acute intracerebral hemorrhage (AIH). Statistically significant difference was found between AIH and control groups in terms of albumin, IMAR, TOS, OSI levels (P < .001, P < .001, P < .001, and P < .001, respectively). Statistically significant difference was found between ACI and control groups in terms of albumin, IMA, IMAR, TOS, and OSI levels (P < .001, P = .045, P < .001, P < .001, and P < .001, respectively). There was no difference between ACI patients with detected acute infarcts on cranial computed tomographic scans (n = 31) and ACI patients with normal cranial computed tomography results (n = 29) in terms of oxidant-antioxidant levels. There was a significant difference between patients admitted within 3 hours and healthy adults regarding the levels of IMAR, TOS, and OSI (P < .001, P < .001, and P < .001, respectively).


CONCLUSIONS
It was seen that oxidant-antioxidant balance was impaired in favor of oxidants in ACI and AIH. In addition, impairment in oxidant-antioxidant balance was found in the early stages of ACI. Therefore, these biomarkers can be used especially in the early diagnosis of thrombolytic therapy candidates in ACI.
Department of Emergency Medicine, Ümraniye Education and Research Hospital, İstanbul, Turkey. Electronic address: doktoratik@hotmail.com.
İsmail
İ
Atik
Department of Emergency Medicine, Antalya Education and Research Hospital, Antalya, Turkey. Electronic address: nalankozaci@gmail.com.
Nalan
N
Kozacı
Department of Emergency Medicine, Antalya Education and Research Hospital, Antalya, Turkey. Electronic address: inan_beydilli@hotmail.com.
İnan
İ
Beydilli
Department of Emergency Medicine, Antalya Education and Research Hospital, Antalya, Turkey. Electronic address: dravcimustafa@gmail.com.
Mustafa
M
Avcı
Department of Biochemistry Medicine, Antalya Education and Research Hospital, Antalya, Turkey. Electronic address: hayael1980@hotmail.com.
Hamit
H
Ellidağ
Department of Emergency Medicine, Antalya Education and Research Hospital, Antalya, Turkey. Electronic address: mustafakesapli@hotmail.com.
Mustafa
M
Keşaplı
D000328:Adult; D000975:Antioxidants / Q000737:chemistry*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004632:Emergency Medical Services; D005260:Female; D006801:Humans; D008297:Male; D016877:Oxidants / Q000097:blood*; D018384:Oxidative Stress; D012709:Serum Albumin / Q000737:chemistry; D020521:Stroke / Q000097:blood*; D014421:Turkey
D000975:Antioxidants; D015415:Biomarkers; D016877:Oxidants; D012709:Serum Albumin