Magnetically Responsive Negative Acoustic Contrast Microparticles for Bioanalytical Applications.
Smart colloidal particles are routinely used as carriers for biological molecules, fluorescent reporters, cells, and other analytes for the purposes of sample preparation and detection. However, such particles are typically engineered to respond to a single type of stimulus (e.g., commercial magnetic beads to magnetic fields). Here, we demonstrate a unique class of particles that display both positive magnetic contrast and negative acoustic contrast in water. This dual functionality allows for fine spatiotemporal control, enabling multiple separation modalities and increasing the utility of the particles in various chemical and biological assays.
Korine A
KA
Ohiri
Department of Physics, Elon University , Elon, North Carolina 27244, United States.
Benjamin A
BA
Evans
C Wyatt
CW
Shields
Robert A
RA
Gutiérrez
Nick J
NJ
Carroll
Benjamin B
BB
Yellen
Department of Chemical & Biological Engineering, University of New Mexico , Albuquerque, New Mexico 87131, United States.
Gabriel P
GP
López
D000162:Acoustics; D018189:Immunomagnetic Separation; D060526:Magnetic Fields; D008280:Magnetics
acoustophoresis; bioanalytical chemistry; colloids; elastomeric particles; magnetophoresis; microfluidics