Smartphone Operated Signal Transduction by Ion Nanogating (STING) Amplifier for Nanopore Sensors: Design and Analytical Application.
In this report, we demonstrated a handheld wireless voltage-clamp amplifier for current measurement of nanopore sensors. This amplifier interfaces a sensing probe and connects wirelessly with a computer or smartphone for the required stimulus input, data processing and storage. To test the proposed Signal Transduction by Ion Nanogating (STING) wireless amplifier, in the current study the system was tested with a nano-pH sensor to measure pH of standard buffer solutions and the performance was compared against the commercial voltage-clamp amplifier. To our best knowledge, STING amplifier is the first miniaturized wireless voltage-clamp platform operated with a customized smart-phone application (app).
Biomolecular Engineering Department, University of California, Santa Cruz, Santa Cruz, CA 95064.
Rıfat Emrah
RE
Özel
Computer Engineering Department, University of California, Santa Cruz, Santa Cruz, CA 95064.
Sina
S
Kahnemouyi
Biomolecular Engineering Department, University of California, Santa Cruz, Santa Cruz, CA 95064.
Hsinwen
H
Fan
Biomolecular Engineering Department, University of California, Santa Cruz, Santa Cruz, CA 95064.
Wai Han
WH
Mak
Biomolecular Engineering Department, University of California, Santa Cruz, Santa Cruz, CA 95064.
Akshar
A
Lohith
Biomolecular Engineering Department, University of California, Santa Cruz, Santa Cruz, CA 95064.
Adam
A
Seger
Computer Engineering Department, University of California, Santa Cruz, Santa Cruz, CA 95064.
Mircea
M
Teodorescu
Biomolecular Engineering Department, University of California, Santa Cruz, Santa Cruz, CA 95064.
Nader
N
Pourmand
Biosensor; Ionic Conductance; Low noise; Miniaturized sensing device; Nanopipette; Point-of-care; Portable instrumentation; Voltage-clamp