Epidemiology and pathology of Paget's disease of bone - a review.
Paget's disease of bone (PDB) is a noninflammatory, metabolic, skeletal disorder characterized by localized excessive osteoclastic bone resorption that is followed by compensatory increased osteoblastic activity leading to unstructured, fibroblastic, and biomechanically unstable bone. As a result, there is deformity and enlargement of the bone with a defective and disorganized pattern. Here, we review the epidemiology, etiology, pathology, macrostructure, histology, and quantitative histomorphometry findings of PDB. Hyperosteoclastosis and poor definition of the boundary between cortical and medullary bone are the main histological findings in PDB. Additionally, Pagetic bone is also characterized by hypertrophy and alteration of trabecular parameters.
Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria. elena.nebotvalenzuela@meduniwien.ac.at.|Department of Physiology, School of Pharmacy, and Institute of Nutrition and Food Technology, University of Granada, Granada, Spain. elena.nebotvalenzuela@meduniwien.ac.at.
Elena
http://orcid.org/0000-0001-9689-6945
E
Nebot Valenzuela
Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Peter
P
Pietschmann
D000328:Adult; D000368:Aged; D015519:Bone Density / Q000502:physiology; D016723:Bone Remodeling / Q000502:physiology; D001862:Bone Resorption / Q000235:genetics / Q000503:physiopathology; D001842:Bone and Bones / Q000473:pathology*; D000071556:Cancellous Bone / Q000473:pathology; D003431:Cross-Cultural Comparison; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology*; D010006:Osteoblasts / Q000473:pathology; D010010:Osteoclasts / Q000473:pathology; D010012:Osteogenesis / Q000502:physiology; D014057:Tomography, X-Ray Computed
Bone structure; Histology; Histomorphometry; Pagetic bone; Skeletal disorder