Behavioral Activity and Some Markers of Posttraumatic Stress Disorder among Serotoninergic System Indicators and Glucocorticoid Metabolizing Enzymes in Rats with Different Duration of Hexenal Sleep.
Post-traumatic stress disorder was imitated in rats with long and short hexenal sleep by exposure to cat odor. Rats with long hexenal sleep demonstrated the highest sensitivity to posttraumatic stress disorders and developed anxiety and depressive disorders. The duration of hexenal sleep correlated with changes in markers of post-traumatic stress disorder, e.g. activity of 11β-hydroxysteroid dehydrogenase-2 in the liver of non-stressed animals and serotonin and monoamine oxidase A activity in the brain of stressed animals.
South Ural State University, Chelyabinsk, Russia.
O B
OB
Tseylikman
South Ural State University, Chelyabinsk, Russia.
M S
MS
Lapshin
South Ural State Medical University, Chelyabinsk, Russia.
D A
DA
Kozochkin
South Ural State Medical University, Chelyabinsk, Russia.
M V
MV
Komel'kova
South Ural State Medical University, Chelyabinsk, Russia.
O V
OV
Kuzina
South Ural State Medical University, Chelyabinsk, Russia.
S V
SV
Golodniy
Vitebsk State Medical University, Vitebsk, Belarus.
S S
SS
Lazuko
South Ural State University, Chelyabinsk, Russia. vadimed@yandex.ru.
V E
VE
Tseylikman
D042842:11-beta-Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D000818:Animals; D001007:Anxiety / Q000378:metabolism; D001522:Behavior, Animal / Q000502:physiology; D003345:Corticosterone / Q000378:metabolism; D005938:Glucocorticoids / Q000378:metabolism*; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D012890:Sleep / Q000502:physiology; D013313:Stress Disorders, Post-Traumatic / Q000378:metabolism*
D005938:Glucocorticoids; D012701:Serotonin; D042842:11-beta-Hydroxysteroid Dehydrogenases; D008995:Monoamine Oxidase; D003345:Corticosterone
11β-hydroxysteroid dehydrogenase-2; corticosterone; monoamine oxidase A; post-traumatic stress disorder; serotonin