Immunogenicity of MenACWY-CRM in Korean Military Recruits: Influence of Tetanus-Diphtheria Toxoid Vaccination on the Vaccine Response to MenACWY-CRM.
The quadrivalent meningococcal conjugate vaccine (MenACWY-CRM) has been introduced for military recruits in Korea since 2012. This study was performed to evaluate the immunogenicity of MenACWY-CRM in Korean military recruits. In addition, the influence of tetanus-diphtheria toxoids (Td) vaccination on the vaccine response to MenACWY-CRM was analyzed. A total of 75 military recruits were enrolled. Among them, 18 received a dose of MenACWY-CRM only (group 1), and 57 received Td three days before MenACWY-CRM immunization (group 2). The immunogenicity of MenACWY-CRM was compared between the two groups. The serum bactericidal activity with baby rabbit complement was measured before and three weeks after immunization against serogroups A, C, W-135, and Y. The geometric mean titers (GMTs) against four serogroups were significantly increased in both groups after immunization. Compared to group 2, group 1 exhibited significantly higher vaccine responses in several aspects: post-immune GMTs against serogroup A and C, seroresponse rates against serogroup A, and a fold increases of titers against serogroup A, C, and Y. MenACWY-CRM was immunogenic against all vaccine-serogroups in Korean military recruits. Vaccine response to MenACWY-CRM was influenced by Td administered three days earlier.
Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, Korea.|Center for Vaccine Evaluation and Study, Ewha Womans University School of Medicine, Seoul, Korea.
Han Wool
HW
Kim
Center for Vaccine Evaluation and Study, Ewha Womans University School of Medicine, Seoul, Korea.
In Ho
IH
Park
Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Korea.
Sooseong
S
You
Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Korea.
Hee Tae
HT
Yu
Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Korea.
In Soo
IS
Oh
Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Korea.
Pil Soo
PS
Sung
Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Korea. ecshin@kaist.ac.kr.
Eui Cheol
EC
Shin
Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, Korea.|Center for Vaccine Evaluation and Study, Ewha Womans University School of Medicine, Seoul, Korea. kaykim@ewha.ac.kr.
Kyung Hyo
KH
Kim
D000818:Animals; D004168:Diphtheria Toxoid / Q000737:chemistry / Q000276:immunology*; D005260:Female; D006801:Humans; D007114:Immunization; D007223:Infant; D008297:Male; D008589:Meningococcal Infections / Q000517:prevention & control*; D022401:Meningococcal Vaccines / Q000008:administration & dosage / Q000276:immunology* / Q000627:therapeutic use; D008889:Military Personnel; D011817:Rabbits; D056910:Republic of Korea; D065288:Serogroup; D058248:Serum Bactericidal Antibody Assay; D013745:Tetanus Toxoid / Q000737:chemistry / Q000276:immunology*; D013997:Time Factors; D016896:Treatment Outcome; D014611:Vaccination; D018074:Vaccines, Conjugate / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use
D004168:Diphtheria Toxoid; C525703:MenACWY; D022401:Meningococcal Vaccines; D013745:Tetanus Toxoid; D018074:Vaccines, Conjugate
Neisseria meningitidis; meningococcal vaccine; serum bactericidal antibody assay