Chemodiversity Associated with Cytotoxicity and Antimicrobial Activity of Piper aduncum var. ossanum.
Chemical analysis, antimicrobial activity and cytotoxic effects of essential oils (EOs) from leaves of Piper aduncum var. ossanum from two localities Bauta (EO-B) and Ceiba (EO-C), Artemisa Province, Cuba, were determined. EOs were obtained by hydrodistillation and analyzed by gas chromatography/mass spectrometry. EO-B demonstrated higher activity against S. aureus and L. amazonensis; while a lower cytotoxicity on mammalian cells was observed. Both EOs displayed the same activity against Plasmodium falciparum, Trypanosoma cruzi, Trypanosoma brucei, and Leishmania infantum. Both EOs were inactive against Escherichia coli and Candida albicans.
Department of Chemistry, Institute of Pharmacy and Food, Havana University, Calle 222 # 2317 e/23 y 31, Coronela, Lisa, Habana, Havana, 10 400, Cuba.
Yamilet
Y
Gutiérrez
Laboratorios Antidoping, Instituto de Medicina Deportiva, Calle 14 y 100, Reparto Embil, Municipio Boyeros, Ciudad Habana, C.P., 10800, Cuba.
Rodny
R
Montes
Department of Chemistry, Institute of Pharmacy and Food, Havana University, Calle 222 # 2317 e/23 y 31, Coronela, Lisa, Habana, Havana, 10 400, Cuba.
Ramón
R
Scull
Department of Chemistry, Institute of Pharmacy and Food, Havana University, Calle 222 # 2317 e/23 y 31, Coronela, Lisa, Habana, Havana, 10 400, Cuba.
Arturo
A
Sánchez
Laboratory for Microbiology, Parasitology and Hygiene, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Universiteitsplein 1, BE-2610, Antwerp.
Paul
P
Cos
Parasitology Department, Institute of Tropical Medicine 'Pedro Kouri', 10400, Havana, Cuba.
Lianet
L
Monzote
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL, 35899, USA.
William N
WN
Setzer
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000977:Antiparasitic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D018314:Leishmania infantum / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity*; D021261:Parasitic Sensitivity Tests; D031701:Piper / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D013329:Structure-Activity Relationship; D014345:Trypanosoma / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000977:Antiparasitic Agents; D003603:Cytotoxins; D009822:Oils, Volatile
Antimicrobial activities; Antiparasitic activities; Chemodiversity; Cytotoxicities; Essential oils