Sepicanin A- A new geranyl flavanone fromArtocarpus sepicanuswith activity against methicillin-resistantStaphylococcus aureus(MRSA).
Bioassay-guided fractionation of the EtOH extract ofArtocarpus sepicanusDiels leaves has led to the isolation of a new geranyl flavanone (1), along with the known compounds, afzelechin-3-O-α-L-rhamnopyranoside andβ-sitosterol glucoside. The structure of the new compound was established by UV, IR, HRESIMS, 1D and 2D NMR experiments. Antimicrobial testing of the three compounds indicated that1displayed a significant selective antibacterial activity against methicillin-resistantStaphylococcus aureus(MRSA) with IC50and MIC values of 1.4 and 2.9 μM, respectively.
National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
Mohamed M
MM
Radwan
Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
Raquel
R
Rodriguez-Guzman
National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
Susan P
SP
Manly
National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
Melissa
M
Jacob
National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA; Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
Samir A
SA
Ross
Artocarpus sepicanus; Flavanone; Methicillin-resistant Staphylococcus aureus; antibacterial