Systems Perspective of Morbillivirus Replication.
Systems biology refers to system-wide changes in biological components such as RNA/DNA (genomics), protein (proteomics) and lipids (lipidomics). In this review, we provide comprehensive information about morbillivirus replication. Besides discussing the role of individual viral/host proteins in virus replication, we also discuss how systems-level analyses could improve our understanding of morbillivirus replication, host-pathogen interaction, immune response and disease resistance. Finally, we discuss how viroinformatics is likely to provide important insights for understanding genome-genome, genome-protein and protein-protein interactions.
National Centre for Veterinary Type Culture Collections, ICAR-National Research Centre on Equines, Hisar, India.
Naveen
N
Kumar
Sanjay
S
Barua
Riyesh
R
Thachamvally
Bhupendra Nath
BN
Tripathi
D019295:Computational Biology; D060467:Disease Resistance; D054884:Host-Pathogen Interactions; D018103:Morbillivirus / Q000502:physiology*; D049490:Systems Biology; D014779:Virus Replication