Effects of 4% Icodextrin on Experimental Spinal Epidural Fibrosis.
OBJECTIVE
The aim of this experimental study was to investigate whether spinal epidural 4% glucose polymer solution is effective in the prevention of postoperative fibrosis.


METHODS
Twenty eight adult Wistar albino rats were randomly divided into two equal groups, including treatment and control. Both groups underwent L1 vertebral total laminectomy to expose the dura. Topical treatment group received 4% icodextrin. Four weeks later, epidural fibrosis was examined in both groups histologically, biochemically and macroscopically.


RESULTS
Topical use of 4% icodextrin prevented significantly epidural fibrosis following the laminectomy operation.


CONCLUSIONS
Topical 4% icodextrin application inhibits postoperative epidural fibrosis with various mechanisms and prevents adhesions by playing barrier role between tissue surfaces through flotation. Our study is first to present evidence of experimental epidural fibrosis prevention with 4% icodextrin.
Medicana International Istanbul Hospital, Department of Neurosurgery, Istanbul, Turkey.
Turker
T
Karanci
Bilal
B
Kelten
Alper
A
Karaoglan
Nilgun
N
Cinar
Ahmet
A
Midi
Veysel
V
Antar
Hidayet
H
Akdemir
Zeynep
Z
Kara
D000818:Animals; D015314:Dialysis Solutions / Q000008:administration & dosage / Q000494:pharmacology*; D004195:Disease Models, Animal; D004824:Epidural Space / Q000187:drug effects; D005355:Fibrosis / Q000517:prevention & control*; D005936:Glucans / Q000008:administration & dosage / Q000494:pharmacology*; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology*; D000077607:Icodextrin; D007796:Laminectomy / Q000009:adverse effects*; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D013122:Spinal Diseases / Q000209:etiology / Q000517:prevention & control*
D015314:Dialysis Solutions; D005936:Glucans; D000077607:Icodextrin; D005947:Glucose