The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Obesity and Cardiovascular Disease.
Na/K-ATPase has been extensively studied for its ion pumping function, but, in the past several decades, has been identified as a scaffolding and signaling protein. Initially it was found that cardiotonic steroids (CTS) mediate signal transduction through the Na/K-ATPase and result in the generation of reactive oxygen species (ROS), which are also capable of initiating the signal cascade. However, in recent years, this Na/K-ATPase/ROS amplification loop has demonstrated significance in oxidative stress related disease states, including obesity, atherosclerosis, heart failure, uremic cardiomyopathy, and hypertension. The discovery of this novel oxidative stress signaling pathway, holds significant therapeutic potential for the aforementioned conditions and others that are rooted in ROS.
Department of Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA. srikanthan.krithika@gmail.com.
Krithika
K
Srikanthan
Department of Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA. shapiroj@marshall.edu.
Joseph I
JI
Shapiro
Department of Surgery, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA. sodhi@marshall.edu.
Komal
K
Sodhi
D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism*; D006801:Humans; D009765:Obesity / Q000378:metabolism*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D017382:Reactive Oxygen Species; D000254:Sodium-Potassium-Exchanging ATPase
Na/K-ATPase; cardiovascular disease; obesity; oxidative stress; pNaKtide