Renal epithelioid angiomyolipoma: Histopathologic review, immunohistochemical evaluation and prognostic significance.
Epithelioid angiomyolipoma (EAML) is considered to be a potentially malignant tumor and requires a differential diagnosis from renal cell carcinoma. In this study, we assessed the clinicopathologic features of renal EAML and evaluated the prognostic significance. Among 78 angiomyolipoma (AML) patients, a total of 5 EAMLs were identified, accounting for 6.4% of the total AML cases. The mean age was 41.4 years, and the average tumor size was 12.7 cm in diameter. Association of tuberous sclerosis complex was identified in two cases. One EAML case showed malignant behavior with local recurrence and distant metastasis. The malignant EAML had a larger tumor size, a higher percentage of epithelioid component and atypical epithelioid cells, ≥2 mitoses per 10 high power fields with atypical mitosis, necrosis, extrarenal extension, and carcinoma-like growth pattern. Furthermore, the malignant case revealed p53 immunoreactivity and decreased membranous E-cadherin expression. Pathologic evaluation of adverse prognostic factors will be helpful for risk stratification and prognosis estimation of EAML patients.
Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
Jeong Hwan
JH
Park
Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
Cheol
C
Lee
Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
Ja Hee
JH
Suh
Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
Gilhyang
G
Kim
Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
Boram
B
Song
Department of Pathology, Seoul National University College of Medicine, Seoul, Korea. blue7270@snu.ac.kr.|Kidney Research Institute, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea. blue7270@snu.ac.kr.
Kyung Chul
KC
Moon
D000328:Adult; D018207:Angiomyolipoma / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis; D015622:Epithelioid Cells / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D055815:Young Adult
D014408:Biomarkers, Tumor
E-cadherin; diagnosis; epithelioid angiomyolipoma; p53; prognosis