Biocompatible Stimuli-Responsive W/O/W Multiple Emulsions Prepared by One-Step Mixing with a Single Diblock Copolymer Emulsifier.
Multiple water-in-oil-in-water (W/O/W) emulsions are promising materials in designing carriers of hydrophilic molecules or drug delivery systems, provided stability issues are solved and biocompatible chemicals can be used. In this work, we designed a biocompatible amphiphilic copolymer, poly(dimethylsiloxane)-b-poly(2-(dimethylamino)ethyl methacrylate) (PDMS-b-PDMAEMA), that can stabilize emulsions made with various biocompatible oils. The hydrophilic/hydrophobic properties of the copolymer can be adjusted using both pH and ionic strength stimuli. Consequently, the making of O/W (oil in water), W/O (water in oil), and W/O/W emulsions can be achieved by sweeping the pH and ionic strength. Of importance, W/O/W emulsions are formulated over a large pH and ionic strength domain in a one-step emulsification process via transitional phase inversion and are stable for several months. Cryo-TEM and interfacial tension studies show that the formation of these W/O/W emulsions is likely to be correlated to the interfacial film curvature and microemulsion morphology.
Sciences et Ingénierie de la Matière Molle, UMR CNRS 7615, ESPCI ParisTech, PSL Research University , 10 rue Vauquelin, Paris 75005, France.|LIONS, NIMBE, CEA, CNRS, Université Paris-Saclay , CEA Saclay, 91191 Gif-sur-Yvette Cedex, France.
Marine
M
Protat
Sciences et Ingénierie de la Matière Molle, UMR CNRS 7615, ESPCI ParisTech, PSL Research University , 10 rue Vauquelin, Paris 75005, France.|LIONS, NIMBE, CEA, CNRS, Université Paris-Saclay , CEA Saclay, 91191 Gif-sur-Yvette Cedex, France.
Noémie
N
Bodin
LIONS, NIMBE, CEA, CNRS, Université Paris-Saclay , CEA Saclay, 91191 Gif-sur-Yvette Cedex, France.
Frédéric
F
Gobeaux
LIONS, NIMBE, CEA, CNRS, Université Paris-Saclay , CEA Saclay, 91191 Gif-sur-Yvette Cedex, France.
Florent
F
Malloggi
Synchrotron Soleil, L'Orme des Merisiers, Saint-Aubin - BP 48, 91192 Gif-sur-Yvette Cedex, France.
Jean
J
Daillant
Sciences et Ingénierie de la Matière Molle, UMR CNRS 7615, ESPCI ParisTech, PSL Research University , 10 rue Vauquelin, Paris 75005, France.|Sorbonne-Universités, UPMC Université Paris 06, SIMM , 10 rue Vauquelin, Paris 75005, France.
Nadège
N
Pantoustier
LIONS, NIMBE, CEA, CNRS, Université Paris-Saclay , CEA Saclay, 91191 Gif-sur-Yvette Cedex, France.
Patrick
P
Guenoun
Sciences et Ingénierie de la Matière Molle, UMR CNRS 7615, ESPCI ParisTech, PSL Research University , 10 rue Vauquelin, Paris 75005, France.|Sorbonne-Universités, UPMC Université Paris 06, SIMM , 10 rue Vauquelin, Paris 75005, France.
Patrick
P
Perrin