[The delivery of therapeutic plasma: Therapeutic plasma of today and tomorrow].
Since plasma for direct therapeutic use comprises no cellular fraction, it has long stood for a standardized and rather simple component; meanwhile, rules for its issuing to patients have long been strict. During the very last years, there has been a paradigm shift as novel indications have raised and possible needs for distinct types of plasma depending on the missing clotting factors in the patient. During the same period of time, plasma inactivated by solvent-detergent, which was a labile component in France, has been re-qualified by European authorities as a plasma derived-drug. The French recommendations for use of plasma - though quite recently revised (2012) - are disputed by some experts and would merit a revisit. This state-of-the art manuscript aims at presenting the novel situation of therapeutic plasma and suggesting possible evolution.
EA3064, faculté de médecine de Saint-Etienne, université de Lyon, 42023 Saint-Étienne cedex 02, France; Institut national de la transfusion sanguine, 75739 Paris cedex 15, France. Electronic address: ogarraud@ints.fr.
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D000071120:ADAMTS13 Protein / Q000172:deficiency; D001793:Blood Preservation / Q000379:methods; D058731:Blood Safety; D001803:Blood Transfusion / Q000592:standards / Q000639:trends*; D003902:Detergents; D004630:Emergencies; D005260:Female; D005544:Forecasting; D005602:France; D006470:Hemorrhage / Q000209:etiology / Q000628:therapy; D006474:Hemorrhagic Disorders / Q000235:genetics / Q000628:therapy; D006801:Humans; D007880:Legislation, Drug; D008297:Male; D010949:Plasma; D010951:Plasma Exchange / Q000379:methods / Q000592:standards / Q000639:trends*; D006473:Postpartum Hemorrhage / Q000628:therapy; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D012997:Solvents; D014947:Wounds and Injuries / Q000150:complications
D003902:Detergents; D012997:Solvents; D000071120:ADAMTS13 Protein; C099604:ADAMTS13 protein, human
Clinique transfusionnelle; Hemovigilance; Hémovigilance; Labile blood component; Médicament dérivé du plasma; Plasma derived-drug; Plasma thérapeutique; Produit sanguin labile; Therapeutic plasma; Transfusion; Transfusion medicine