Effects of isotretinoin on body mass index, serum adiponectin, leptin, and ghrelin levels in acne vulgaris patients.
BACKGROUND
Isotretinoin has been successfully used for the treatment of acne vulgaris.


OBJECTIVE
To investigate the effects of isotretinoin on body mass index (BMI), to determine whether isotretinoin causes any changes in serum adiponectin, leptin, and ghrelin levels in acne vulgaris patients, and to correlate variables.


METHODS
Thirty-two patients were included in this study. Oral isotretinoin was begun at a dose of 0.5-0.6 mg/kg and raised to 0.6-0.75 mg/kg. Pretreatment and posttreatment third-month BMI and adiponectin, leptin, and ghrelin serum levels were measured.


RESULTS
The pre- and posttreatment BMI values were not significantly different. In addition, serum adiponectin and leptin levels were significantly increased following isotretinoin therapy while serum ghrelin levels were not different.


CONCLUSIONS
Isotretinoin may exert its anti-inflammatory activity by increasing leptin and adiponectin levels.
Department of Dermatology, Ministry of Health Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey.
Bengu Cevirgen
BC
Cemil
Department of Dermatology, Ministry of Health Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey.
Havva Hilal
HH
Ayvaz
Department of Biochemistry, Ministry of Health Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey.
Gulfer
G
Ozturk
Department of Dermatology, Ministry of Health Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey.
Can
C
Ergin
Department of Dermatology, Ministry of Health Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey.
Havva Kaya
HK
Akıs
Department of Dermatology, Ministry of Health Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey.
Muzeyyen
M
Gonul
Department of Biochemistry, Ministry of Health Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey.
Ercan
E
Arzuhal
acne vulgaris; adipocytokines; body mass index; ghrelin; isotretinoin