Effect of Repeated Antimicrobial Photodynamic Therapy in Treatment of Periodontitis Associated with Fanconi Anemia.
OBJECTIVE
Periodontal disease is one of common oral manifestations in patients with Fanconi anemia (FA). The aim of the study was to evaluate the effect of photodynamic therapy (PDT) on periodontal clinical and microbial parameters in a patient with FA.


METHODS
For a 16-year-old girl, diagnosed with having FA and periodontal disease, the protocol treatment with duration of 10 months was designed. Every 2 months, thorough oral cavity disinfection was followed by PDT, using photosensitizer phenothiazine chloride activated by a diode laser light. During each visit, periodontal parameters were evaluated: plaque index (PI), gingival index (GI), probing pocket depth (PPD), bleeding on probing (BOP), and clinical attachment level. Simultaneously, the presence of Candida albicans and of five periodontal pathogens was evaluated.


RESULTS
Clinical results showed improvement in GI, BOP, and PPD during this 10-month period. BOP subsequently reduced from 100% to 79%, 72%, and 60% at 6, 8, and 10 months, respectively. The proportion of sites with PPD of ≥4 mm decreased from 38.7% at the baseline to zero after 10 months. Further, all five bacterial species and C. albicans were reduced significantly.


CONCLUSIONS
PDT effectively influences periodontal healing and reduces periodontopathogenic bacteria without damaging the patient's tissues.
1 Department of Paediatric and Preventive Dentistry, Faculty of Medicine, University of Ljubljana , Ljubljana, Slovenia .
Alenka
A
Pavlič
2 Unit of Oral Medicine and Periodontology, Division of Stomatology, University Medical Centre Ljubljana , Ljubljana, Slovenia .
Urban
U
Matoh
3 Department of Haematology and Oncology, University Children's Hospital , Ljubljana, Slovenia .
Vladan
V
Rajić
4 Department of Oral Medicine and Periodontology, Faculty of Medicine, University of Ljubljana , Ljubljana, Slovenia .
Milan
M
Petelin
D000293:Adolescent; D005199:Fanconi Anemia / Q000150:complications*; D005260:Female; D006801:Humans; D010518:Periodontitis / Q000382:microbiology / Q000628:therapy*; D010778:Photochemotherapy
oral pathologies; photodynamic therapy (PDT); tissue regeneration and healing