Antiplasmodial activity of alkyl-substituted 1,2-dioxetanes against Plasmodium falciparum.
This article reports the in vitro antiplasmodial activity of two endoperoxides of the class 1,2-dioxetanes against Plasmodium falciparum: bis(adamantyl)-1,2-dioxetane and 3,3,4,4-tetramethyl-1,2-dioxetane. The results reveal that bis(adamantyl)-1,2-dioxetane displays substantial antiplasmodial activity, at least two orders of magnitude higher than that of artemisinin, while 3,3,4,4-tetramethyl-1,2-dioxetane is less active.
Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Avenida dos Estados 5001, Santo André, SP 09210-580, Brazil.
Adriana F
AF
Silva
Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Avenida dos Estados 5001, Santo André, SP 09210-580, Brazil.
Vani X
VX
Oliveira
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Leandro S
LS
Silva
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Ana A S
AAS
Pinheiro
Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Avenida dos Estados 5001, Santo André, SP 09210-580, Brazil. Electronic address: luiz.ciscato@ufabc.edu.br.
Luiz F M L
LFML
Ciscato
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D006461:Hemolysis / Q000187:drug effects; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000494:pharmacology*; D006573:Heterocyclic Compounds, 1-Ring; D010963:Plasmodium falciparum / Q000187:drug effects*
D000962:Antimalarials; D006571:Heterocyclic Compounds; D006573:Heterocyclic Compounds, 1-Ring; C079142:1,2-dioxetane
1,2-Dioxetane; Antimalarials; Peroxides