Clinical PET/MR Imaging in Dementia and Neuro-Oncology.
The introduction of hybrid PET/MRI systems allows simultaneous multimodality image acquisition of high technical quality. This technique is well suited for the brain, and particularly in dementia and neuro-oncology. In routine use combinations of well-established MRI sequences and PET tracers provide the most optimal and clinically valuable protocols. For dementia the [18F]-fluorodeoxyglucose (FDG) has merit with a simultaneous four sequence MRI protocol of 20 min supported by supplementary statistical reading tools and quantitative measurements of the hippocampal volume. Clinical PET/MRI using [18F]-fluoro-ethyl-tyrosine (FET) also abide to the expectations of the adaptive and versatile diagnostic tool necessary in neuro-oncology covering both simple 20 min protocols for routine treatment surveillance and complicated 90 min brain and spinal cord protocols in pediatric neuro-oncology under general anesthesia. The clinical value of adding advanced MRI sequences in multiparametric imaging setting, however, is still undocumented.
Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, 9, Blegdamsvej, Copenhagen 2100-DK, Denmark.
Otto M
OM
Henriksen
Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, 9, Blegdamsvej, Copenhagen 2100-DK, Denmark.
Lisbeth
L
Marner
Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, 9, Blegdamsvej, Copenhagen 2100-DK, Denmark. Electronic address: ilaw@dadlnet.dk.
Ian
I
Law
D001921:Brain / Q000000981:diagnostic imaging; D001931:Brain Mapping / Q000379:methods; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D003704:Dementia / Q000000981:diagnostic imaging*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D064847:Multimodal Imaging / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods*
Alzheimer disease; Brain tumor; Dementia; Glioma; PET/MR imaging