Oral administration of an aqueous extract from the oyster mushroom Pleurotus ostreatus enhances the immunonutritional recovery of malnourished mice.
Mushroom nutriceutical components have lately attracted interest for developing immunonutritional support. However, there is relatively little information pertaining to the use of mushroom preparations for modulating the metabolic and immunological disorders associated to malnutrition. This study was aimed to evaluate the effects of oral administration of an aqueous extract (CW-P) from Pleurotus ostreatus on the recovery of biochemical and immunological functions of malnourished mice. 8-week old female BALB/c mice were starved for 3days and then refed with commercial diet supplemented with or without CW-P (100mg/kg) for 8days. Regardless of the diet used during refeeding, animal body weights and serum protein concentrations did not differ between groups. Oral treatment with CW-P normalized haemoglobin levels, liver arginase and gut mucosal weight. CW-P increased total liver proteins and also DNA and protein contents in gut mucosa. Pleurotus extract provided benefits in terms of macrophages activation as well as in haemopoiesis, as judged by the recovery of bone marrow cells and leukocyte counts. Moreover, CW-P stimulated humoral immunity (T-dependent and T non-dependent antibodies responses) compared to non-supplemented mice. CW-P extract from the oyster mushroom can be used to develop specific food or nutritional supplement formulations with potential clinical applications in the immunotherapy.
Centre of Studies for Industrial Biotechnology, University of Oriente, Ave. Patricio Lumumba s/n, Reparto Jiménez, Santiago de Cuba, 5, CP 90 500, Cuba. Electronic address: gabriel@uo.edu.cu.
Gabriel
G
Llauradó
Centre of Studies for Industrial Biotechnology, University of Oriente, Ave. Patricio Lumumba s/n, Reparto Jiménez, Santiago de Cuba, 5, CP 90 500, Cuba.
Humberto J
HJ
Morris
Centre of Studies for Industrial Biotechnology, University of Oriente, Ave. Patricio Lumumba s/n, Reparto Jiménez, Santiago de Cuba, 5, CP 90 500, Cuba.
Yamila
Y
Lebeque
Faculty of Medicine No. 2, Medical University of Santiago de Cuba, Santiago de Cuba 4, CP 90400, Cuba.
Gleymis
G
Venet
Centre of Toxicology and Biomedicine, Medical University of Santiago de Cuba, Autopista Nacional Km 1 1/2, Apdo Postal 4033, Santiago de Cuba, Cuba.
Onel
O
Fong
Centre of Toxicology and Biomedicine, Medical University of Santiago de Cuba, Autopista Nacional Km 1 1/2, Apdo Postal 4033, Santiago de Cuba, Cuba.
Jane
J
Marcos
Centre of Studies for Industrial Biotechnology, University of Oriente, Ave. Patricio Lumumba s/n, Reparto Jiménez, Santiago de Cuba, 5, CP 90 500, Cuba.
Roberto
R
Fontaine
Laboratory for Microbiology, Parasitology and Hygiene, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium.
Paul
P
Cos
Centre of Studies for Industrial Biotechnology, University of Oriente, Ave. Patricio Lumumba s/n, Reparto Jiménez, Santiago de Cuba, 5, CP 90 500, Cuba.
Rosa C
RC
Bermúdez
D000284:Administration, Oral; D000818:Animals; D019587:Dietary Supplements; D005260:Female; D044342:Malnutrition / Q000178:diet therapy* / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D020076:Pleurotus; D020127:Recovery of Function / Q000276:immunology*; D014867:Water / Q000008:administration & dosage
D010936:Plant Extracts; D014867:Water
Immunonutrition; Macrophage activation; Malnutrition; Nutritional support; Pleurotus extract