Molecular subtypes and imaging phenotypes of breast cancer.
During the last 15 years, traditional breast cancer classifications based on histopathology have been reorganized into the luminal A, luminal B, human epidermal growth factor receptor 2 (HER2), and basal-like subtypes based on gene expression profiling. Each molecular subtype has shown varying risk for progression, response to treatment, and survival outcomes. Research linking the imaging phenotype with the molecular subtype has revealed that non-calcified, relatively circumscribed masses with posterior acoustic enhancement are common in the basal-like subtype, spiculated masses with a poorly circumscribed margin and posterior acoustic shadowing in the luminal subtype, and pleomorphic calcifications in the HER2-enriched subtype. Understanding the clinical implications of the molecular subtypes and imaging phenotypes could help radiologists guide precision medicine, tailoring medical treatment to patients and their tumor characteristics.
Department of Radiology, Seoul National University Hospital, Seoul, Korea.|Department of Radiology, Seoul National University College of Medicine, Seoul, Korea.|Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Korea.
Nariya
0000-0003-4290-2777
N
Cho
Breast neoplasms; Diagnosis; Gene expression profiling; Ultrasonography