Research Advances in Pituitary Adenoma and DNA Methylation.
DNA methylation is closely related to the genesis and development of pituitary adenoma. Studies have shown that high methylation in the promoter region of potassium voltage-gated chanel,shaker related subfamily,beta member 2,O-6-methylguanine-DNA methyltransferase,echinoderm microtubule associated protein like 2 ,ras homolog family member D ,homeobox B1 ,NNAT, and P16 inhibits the expression of these genes and regulates of the proliferation of pituitary adenoma. DNA methylation is also closely related to invasive pituitary adenoma. Therefore,further study on molecular mechanism of DNA methylation of pituitary adenoma will offer a new strategy for the diagnosis and treatment of pituitary adenoma.
Department of Neurosurgery,the First Hospital Affiliated to Dalian Medical University,Dalian,Liaoning 116011,China.
Zhen-Qing
ZQ
Wei
Department of Neurosurgery,the First Hospital Affiliated to Dalian Medical University,Dalian,Liaoning 116011,China.
Yang
Y
Li
Department of Neurosurgery,the First Hospital Affiliated to Dalian Medical University,Dalian,Liaoning 116011,China.
Wei-Hua
WH
Li
Department of Neurosurgery,the Second Hospital Affiliated to Dalian Medical University,Dalian,Liaoning 116000,China.
Jia-Cheng
JC
Lou
Department of Neurosurgery,the Second Hospital Affiliated to Dalian Medical University,Dalian,Liaoning 116000,China.
Bo
B
Zhang
D000236:Adenoma / Q000235:genetics*; D019175:DNA Methylation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D010911:Pituitary Neoplasms / Q000235:genetics*; D011401:Promoter Regions, Genetic