[Indications and results for protontherapy in cancer treatments].
Purpose was to summarize results for proton therapy in cancer treatment. A systematic review has been done by selecting studies on the website www.pubmed.com (Medline) and using the following keywords: proton therapy, radiation therapy, cancer, chordoma, chondrosarcoma, uveal melanoma, retinoblastoma, meningioma, glioma, neurinoma, pituitary adenoma, medulloblastoma, ependymoma, craniopharyngioma and nasal cavity. There are several retrospective studies reporting results for proton therapy in cancer treatments in the following indications: ocular tumors, nasal tumors, skull-based tumors, pediatric tumors. There is no prospective study except one phase II trial in medulloblastoma. The use of proton therapy for these indications is due to dosimetric advantages offering better tumor coverage and organ at risk sparing in comparison with photon therapy. Clinical results are historically at least as efficient as photon therapy with a better toxicity profile in pediatric tumors (cognitive and endocrine functions, radiation-induced cancer) and a better tumoral control in tumors of the nasal cavity. Clinical advantages of proton therapy counterbalance its cost especially in pediatric tumors. Proton therapy could be used in other types of cancer. Proton therapy showed good outcome in ocular, nasal tumors, pediatric, skull-based and paraspinal tumors. Because of some dosimetric advantages, proton therapy could be proposed for other indications in cancer treatments.
Centre Antoine-Lacassagne, radiation oncology, 33, avenue de Valombrose, 06189 Nice, France. Electronic address: jerome.doyen@nice.unicancer.fr.
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Doyen
Centre Antoine-Lacassagne, radiation oncology, 33, avenue de Valombrose, 06189 Nice, France.
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PY
Bondiau
Centre Antoine-Lacassagne, radiation oncology, 33, avenue de Valombrose, 06189 Nice, France.
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K
Benezery
Centre Antoine-Lacassagne, radiation oncology, 33, avenue de Valombrose, 06189 Nice, France.
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Thariat
Centre Antoine-Lacassagne, radiation oncology, 33, avenue de Valombrose, 06189 Nice, France.
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Vidal
Centre Antoine-Lacassagne, radiation oncology, 33, avenue de Valombrose, 06189 Nice, France.
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Gérard
Centre Antoine-Lacassagne, radiation oncology, 33, avenue de Valombrose, 06189 Nice, France.
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Hérault
Centre Léon-Bérard, radiation oncology, 28, rue Laennec, 69008 Lyon, France.
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Carrie
Centre Antoine-Lacassagne, radiation oncology, 33, avenue de Valombrose, 06189 Nice, France.
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JM
Hannoun-Lévi
D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*; D061766:Proton Therapy / Q000009:adverse effects; D018714:Radiotherapy, Adjuvant
Cancer; Ocular tumors; Pediatric tumors; Proton therapy; Protonthérapie; Radiotherapy; Radiothérapie; Skull-based tumors; Tumeurs de la base du crâne; Tumeurs oculaires; Tumeurs pédiatriques