Idiopathic polyhydramnios at term and pregnancy outcomes: a multicenter observational study.
OBJECTIVE
To assess pregnancy outcomes in pregnancies with idiopathic polyhydramnios at term.


METHODS
We conducted a retrospective cohort study of 106 225 term pregnancies from 37 hospitals in China. Maternal and fetal outcomes in pregnancies with idiopathic polyhydramnios were compared with pregnancies with normal amniotic fluid. The primary outcome was intra-uterine fetal death (IUFD).


RESULTS
In all, 307 out of 106 225 (0.3%) had idiopathic polyhydramnios at term, 276 of which were mild and 31 of which were moderate-severe. Compared to term pregnancies with normal amniotic fluid, pregnancies idiopathic polyhydramnios was associated with over 24-fold higher risk for IUFD (adjusted odds ratio [aOR] 24.4, 95% confidence interval (CI) 7.3-82.0), macrosomia (aOR 2.8, 95%CI 2.0-3.8), malpresentation (aOR 2.5, 95%CI 1.7-3.7), cesarean delivery (aOR 2.5, 95%CI 1.7-3.7) and low APGAR scores at 5 min (aOR 4.3, 95%CI 2.4-7.8), which increased with severity of idiopathic polyhydramnios.


CONCLUSIONS
Term pregnancies with idiopathic polyhydramnios, especially moderate-severe ones are at a significantly increased rate for adverse pregnancy outcome. Increased antepartum surveillance of fetal well-being and timed delivery are warranted.
a Department of Obstetrics and Gynecology , Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China , and.
Qing-Qing
QQ
Luo
a Department of Obstetrics and Gynecology , Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China , and.
Li
L
Zou
a Department of Obstetrics and Gynecology , Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China , and.
Hui
H
Gao
a Department of Obstetrics and Gynecology , Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China , and.
Yan-Fang
YF
Zheng
a Department of Obstetrics and Gynecology , Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China , and.
Yin
Y
Zhao
b Department of Obstetrics , Beijing Obstetrics and Gynecology Hospital, Capital Medical University , Beijing , China.
Wei-Yuan
WY
Zhang
D000328:Adult; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D006831:Polyhydramnios / Q000453:epidemiology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D055815:Young Adult
Idiopathic polyhydramnios; amniotic fluid; pregnant outcome; term pregnancy