INTRAPAPILLARY PROLIFERATION IN OPTIC DISK PITS: Clinical Findings and Time-Related Changes.
OBJECTIVE
To investigate the structural changes of intrapapillary proliferations associated with optic disk pits (ODPs) and optic disk pit maculopathy (ODP-M) using enhanced depth-spectral domain-optical coherence tomography (SD-EDI-OCT) and megahertz optical coherence tomography (MHz-OCT).


METHODS
Sixteen eyes of patients with ODPs were studied. Papillary and peripapillary areas were repeatedly examined with SD-EDI-OCT over time. To evaluate swept-source OCT, some of the patients additionally received MHz-OCT-imaging.


RESULTS
MHz-OCT or SD-EDI images showed the entire form of the pits from opening to bottom in 13 of the 16 cases. The shape of ODPs varied considerably. In patients with unilateral ODP, deep intrapapillary depressions in the optic disk of the contralateral partner eye were a prevalent finding. Intrapapillary proliferations were observed in all ODP-cases during follow-up. The aspect of intrapapillary and prepapillary tissue, septae, and cavities changed over time. This effect was especially pronounced inside the ODP while the eye experienced simultaneous ODP-M.


CONCLUSIONS
All examined eyes with ODP showed signs of intrapapillary and prepapillary tissue, which developed over time. SD-EDI-OCT and MHz-OCT are able to detect characteristic ODP-related findings and are a useful means to monitor time-related changes within intrapapillary and prepapillary tissue related to ODP and ODP-M.
*Department of Ophthalmology, Ludwig-Maximilians University Munich, Munich, Germany; †Institute for Biomolecular Optics, Faculty of Physics, Ludwig-Maximilians-University, Munich, Germany; and ‡Institute of Biomedical Optics, University of Lübeck, Germany.
Josef
J
Maertz
Kathrin J
KJ
Mohler
Jan P
JP
Kolb
Thomas
T
Kein
Aljoscha
A
Neubauer
Anselm
A
Kampik
Siegfried
S
Priglinger
Wolfgang
W
Wieser
Robert
R
Huber
Armin
A
Wolf
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D018450:Disease Progression; D005124:Eye Abnormalities / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000002:abnormalities* / Q000000981:diagnostic imaging; D009901:Optic Nerve Diseases / Q000000981:diagnostic imaging*; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000379:methods; D055815:Young Adult