Effects of Targeting Higher or Lower Oxygen Saturations in Centers with More Versus Less Separation between Median Saturations.
Subgroup analysis of the Canadian Oxygen Trial to compare outcomes of extremely preterm infants in centers with more versus less separation between median arterial oxygen saturations in the two target ranges.Centers with more separation observed lower rates of death or disability in the 85%-89% range than in the 91%-95% target range.
Division of Neonatology, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada. Electronic address: barbara.schmidt@uphs.upenn.edu.
Barbara
B
Schmidt
Department of Pediatrics, Dalhousie University, Halifax, Canada.
Robin K
RK
Whyte
Department of Pediatrics, University of Toronto, Toronto, Canada.
Prakesh S
PS
Shah
Division of Neonatology, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA.
Soraya
S
Abbasi
Department of Pediatrics, Laval University, Quebec City, Canada.
Aida
A
Bairam
Department of Pediatrics, University of Ottawa, Ottawa, Canada.
JoAnn
J
Harrold
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada.
Robin S
RS
Roberts
D002170:Canada; D005260:Female; D006801:Humans; D062071:Infant, Extremely Premature / Q000097:blood*; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D010092:Oximetry / Q000379:methods*; D010100:Oxygen / Q000097:blood*; D010102:Oxygen Inhalation Therapy
D010100:Oxygen
extremely preterm infants