Route for the Generation of Trifluoromethyl-Substituted Pyrrplo[3,2-c]quinolines.
Generation of trifluoromethyl-substituted pyrrolo[3,2-c]quinolines via a copper(II)-catalyzed tandem reaction of N-(σ-iodoaryl)alkynylimines with 2-isocyanoacetates is reported. The process involves a [3 + 2] cycloaddition and intramolecular C-C bond coupling, leading to the fluorine-containing N-heterocycles under mild conditions with high efficiency.
Gannan Medical University Collaborative Innovation Center for Gannan Oil-tea Camellia Industrial Development, 1 Yixueyuan Road, Ganzhou, Jiangxi 341000, China.|Department of Chemistry, Fudan University , 220 Handan Road, Shanghai 200433, China.
Danqing
D
Zheng
Department of Chemistry, Fudan University , 220 Handan Road, Shanghai 200433, China.
Tong
T
Liu
Gannan Medical University Collaborative Innovation Center for Gannan Oil-tea Camellia Industrial Development, 1 Yixueyuan Road, Ganzhou, Jiangxi 341000, China.
Xia
X
Liu
Gannan Medical University Collaborative Innovation Center for Gannan Oil-tea Camellia Industrial Development, 1 Yixueyuan Road, Ganzhou, Jiangxi 341000, China.
Xiaona
X
Fan
Department of Chemistry, Fudan University , 220 Handan Road, Shanghai 200433, China.|State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Road, Shanghai 200032, China.
Jie
J
Wu