Increased expression of interleukin 17 in the cortex and hippocampus from patients with mesial temporal lobe epilepsy.
Mesial temporal lobe epilepsy (MTLE) is the most common form of focal epilepsies in adults and proinflammatory cytokines have long been thought to play an important role in pathogenesis and epileptogenicity. In the present study, we investigated the levels and expression patterns of the interleukin 17 (IL-17) system in temporal neocortex and hippocampus from 24 patients with MTLE and 8 control (Ctr) samples. We found that IL-17 and IL-17 receptor (IL-17R) were clearly upregulated in MTLE at both mRNA and protein levels, compared with Ctr. Immunostaining indicated that neurons, astrocytes, microglia and endothelial cells of blood vessels are the major sources of IL-17. These findings suggest that IL-17 system may be involved in the pathogenesis and epileptogenicity of MTLE.
Department of Neurosurgery, Lanzhou General Hospital of PLA, Lanzhou 730050, China.
Jiao-Jiang
JJ
He
Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Fei-Ji
FJ
Sun
Department of Neurosurgery, Lanzhou General Hospital of PLA, Lanzhou 730050, China.
Yu
Y
Wang
Department of Nephrology, Mianzhu People's Hospital, Sichuan 618200, China.
Xiao-Qin
XQ
Luo
Department of Neurosurgery, Lanzhou General Hospital of PLA, Lanzhou 730050, China.
Peng
P
Lei
Department of Neurosurgery, Lanzhou General Hospital of PLA, Lanzhou 730050, China.
Jie
J
Zhou
Department of Neurosurgery, Lanzhou General Hospital of PLA, Lanzhou 730050, China.
Di
D
Zhu
Department of Neurosurgery, Lanzhou General Hospital of PLA, Lanzhou 730050, China. Electronic address: lizhiyun456@163.com.
Zhi-Yun
ZY
Li
Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China. Electronic address: huiyang64@yahoo.com.
Hui
H
Yang
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D002452:Cell Count; D002540:Cerebral Cortex / Q000378:metabolism*; D004833:Epilepsy, Temporal Lobe / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000378:metabolism*; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics / Q000378:metabolism*; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism; D020395:Receptors, Interleukin-7 / Q000235:genetics / Q000378:metabolism*; D055815:Young Adult
D020381:Interleukin-17; D012333:RNA, Messenger; D020395:Receptors, Interleukin-7
Inflammatory cytokine; Interleukin 17; Mesial temporal lobe epilepsy