Significance of the zero sum principle for circadian, homeostatic and allostatic regulation of sleep-wake state in the rat.
Sleep-wake behavior exhibits diurnal rhythmicity, rebound responses to acute total sleep deprivation (TSD), and attenuated rebounds following chronic sleep restriction (CSR). We investigated how these long-term patterns of behavior emerge from stochastic short-term dynamics of state transition. Male Sprague-Dawley rats were subjected to TSD (1day×24h, N=9), or CSR (10days×18h TSD, N=7) using a rodent walking-wheel apparatus. One baseline day and one recovery day following TSD and CSR were analyzed. The implications of the zero sum principle were evaluated using a Markov model of sleep-wake state transition. Wake bout duration (a combined function of the probability of wake maintenance and proportional representations of brief and long wake) was a key variable mediating the baseline diurnal rhythms and post-TSD responses of all three states, and the attenuation of the post-CSR rebounds. Post-NREM state transition trajectory was an important factor in REM rebounds. The zero sum constraint ensures that a change in any transition probability always affects bout frequency and cumulative time of at least two, and usually all three, of wakefulness, NREM and REM. Neural mechanisms controlling wake maintenance may play a pivotal role in regulation and dysregulation of all three states.
University of Toronto, Department of Cell and Systems Biology, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada. Electronic address: richard.stephenson@utoronto.ca.
Richard
R
Stephenson
University of Toronto, Department of Cell and Systems Biology, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada.
Aimee M
AM
Caron
University of Toronto, Department of Cell and Systems Biology, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada.
Svetlana
S
Famina
D052636:Allostasis / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D004569:Electroencephalography; D004576:Electromyography; D006706:Homeostasis / Q000502:physiology*; D008297:Male; D011336:Probability; D051381:Rats; D017207:Rats, Sprague-Dawley; D012890:Sleep / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology*
Chronic sleep restriction; Markov model; Sleep deprivation; Sleep homeostasis; State transition; Zero sum principle