Pharmacokinetics of14C-ortho-phenylphenol following intravenous administration in pigs.
Workers in the USA are exposed to industrial formulations, which may be toxic. These formulations often contain preservatives or biocides such as ortho-phenylphenol (OPP). There are limited data describing OPP following intravenous administration to assess truly the clearance of this chemical in humans and other species. In vivo experiments were conducted in pigs to determine related pharmacokinetic parameters.14C-OPP was administered as an intravenous bolus dose. Blood, feces, urine and tissue samples were collected for analysis by liquid scintillation. Data were analyzed using non-compartmental and compartmental pharmacokinetic model approaches. These data fitted a three-compartment model and showed that the half-life of14C-OPP following the intravenous bolus in pigs was 46.26 ± 10.01 h. The kidneys play a crucial role in clearance of14C-OPP with a large percentage of the dose being found in the urine (70.3 ± 6.9% dose). Comparisons with other species suggest that14C-OPP clearance in pigs (2.48 ml h-1kg-1) is less than that in humans (18.87 ml h-1kg-1) and rats (35.51 ml h-1kg-1). Copyright © 2016 John Wiley & Sons, Ltd.
Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
Emma
E
Nixon
Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
James D
JD
Brooks
Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
Patricia A
PA
Routh
qPharmetra, LLC, Andover, MA, USA.
Jason T
JT
Chittenden
Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
Ronald E
RE
Baynes
D061605:Administration, Intravenous; D000818:Animals; D019540:Area Under Curve; D001713:Biphenyl Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004202:Disinfectants / Q000493:pharmacokinetics*; D005243:Feces / Q000737:chemistry; D006207:Half-Life; D008297:Male; D034421:Sus scrofa; D013552:Swine; D014018:Tissue Distribution
D001713:Biphenyl Compounds; D004202:Disinfectants; C004369:2-phenylphenol
biocide; intravenous dose; ortho-phenylphenol; pharmacokinetics; pig