Vetiverianines A, B, and C: Sesquiterpenoids from Vetiveria zizanioides Roots.
Three new sesquiterpenoids-vetiverianines A (1), B (2), and C (3)-and a known eudesmane sesquiterpenoid (4) were isolated from the roots of Vetiveria zizanioides. Vetiverianine A (1) has a unique carbon framework comprising a rigid tricyclic ring system. Vetiverianines B (2) and C (3) are new eremophilane sesquiterpenoids. The structures of sesquiterpenoids 1-3, including the absolute configurations, were determined by NMR spectroscopic, X-ray crystallography, and vibrational circular dichroism data analysis. Vetiverianine C (3) exhibited weak cytotoxic activity against HL-60 cells.
School of Pharmacy, Tokyo University of Pharmacy and Life Sciences , 1432-1, Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Yukiko
Y
Matsuo
School of Pharmacy, Tokyo University of Pharmacy and Life Sciences , 1432-1, Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Saori
S
Maeda
School of Pharmacy, Tokyo University of Pharmacy and Life Sciences , 1432-1, Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Chika
C
Ohba
School of Pharmacy, Tokyo University of Pharmacy and Life Sciences , 1432-1, Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Haruhiko
H
Fukaya
School of Pharmacy, Tokyo University of Pharmacy and Life Sciences , 1432-1, Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Yoshihiro
Y
Mimaki
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D049930:Chrysopogon / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D007564:Japan; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane; C000620736:vetiverianine C; C015872:eudesmane