Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.
High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants in up to 192,763 individuals and used ∼155,063 samples for independent replication. We identified 30 new blood pressure- or hypertension-associated genetic regions in the general population, including 3 rare missense variants in RBM47, COL21A1 and RRAS with larger effects (>1.5 mm Hg/allele) than common variants. Multiple rare nonsense and missense variant associations were found in A2ML1, and a low-frequency nonsense variant in ENPEP was identified. Our data extend the spectrum of allelic variation underlying blood pressure traits and hypertension, provide new insights into the pathophysiology of hypertension and indicate new targets for clinical intervention.
Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Praveen
P
Surendran
Medical Research Council Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK.|Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, Rayne Building University College London, London, UK.
Fotios
F
Drenos
Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Robin
R
Young
Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK.|National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK.
Helen
H
Warren
Department of Health Sciences, University of Leicester, Leicester, UK.|Department of Biostatistics, University of Liverpool, Liverpool, UK.
James P
JP
Cook
Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.|Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts, USA.|Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Alisa K
AK
Manning
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Niels
N
Grarup
Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.|Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.|Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore.
Xueling
X
Sim
Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Daniel R
DR
Barnes
Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK.|National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK.
Kate
K
Witkowska
Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
James R
JR
Staley
Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Vinicius
V
Tragante
Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.|Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts, USA.|Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Taru
T
Tukiainen
Genetics of Complex Traits, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.
Hanieh
H
Yaghootkar
Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.|National Institute for Health Research Leicester Biomedical Research Unit in Cardiovascular Disease, Leicester, UK.
Nicholas
N
Masca
Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Daniel F
DF
Freitag
Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Teresa
T
Ferreira
Heart Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Olga
O
Giannakopoulou
Heart Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.|National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK.
Andrew
A
Tinker
Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Magdalena
M
Harakalova
Estonian Genome Center, University of Tartu, Tartu, Estonia.
Evelin
E
Mihailov
National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA.
Chunyu
C
Liu
Division of Statistical Genomics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA.|Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.
Aldi T
AT
Kraja
Department of Clinical Biochemistry Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark.
Sune
S
Fallgaard Nielsen
Centre for Non-Communicable Diseases, Karachi, Pakistan.
Asif
A
Rasheed
Centre for Non-Communicable Diseases, Karachi, Pakistan.
Maria
M
Samuel
Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Wei
W
Zhao
Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA.
Lori L
LL
Bonnycastle
Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.|Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Anne U
AU
Jackson
Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA.
Narisu
N
Narisu
Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA.
Amy J
AJ
Swift
Wellcome Trust Sanger Institute, Genome Campus, Hinxton, UK.|Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Lorraine
L
Southam
Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Jonathan
J
Marten
Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.|Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Jeroen R
JR
Huyghe
Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Alena
A
Stančáková
University of Lund, Department of Clinical Sciences, Malmö, Sweden.|University of Verona, Department of Medicine, Verona, Italy.
Cristiano
C
Fava
University of Lund, Department of Clinical Sciences, Malmö, Sweden.
Therese
T
Ohlsson
Wellcome Trust Sanger Institute, Genome Campus, Hinxton, UK.
Angela
A
Matchan
Heart Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.|Department of Haematology, University of Cambridge, Cambridge, UK.
Kathleen E
KE
Stirrups
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jette
J
Bork-Jensen
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Anette P
AP
Gjesing
Department of Health, National Institute for Health and Welfare, Helsinki, Finland.
Jukka
J
Kontto
Department of Health, National Institute for Health and Welfare, Helsinki, Finland.|Institute of Molecular Medicine FIMM, University of Helsinki, Finland.|Estonian Genome Center, University of Tartu, Tartu, Estonia.
Markus
M
Perola
Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK.
Susan
S
Shaw-Hawkins
Department of Health, National Institute for Health and Welfare, Helsinki, Finland.
Aki S
AS
Havulinna
Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.
He
H
Zhang
Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
Louise A
LA
Donnelly
Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Christopher J
CJ
Groves
Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.|Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.|Wellcome Trust Sanger Institute, Genome Campus, Hinxton, UK.
N William
NW
Rayner
Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.|National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital Trusts, Oxford, UK.
Matt J
MJ
Neville
Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.|Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Neil R
NR
Robertson
Section of Investigative Medicine, Imperial College London, London, UK.|Department of Life Sciences, Brunel University London, London, UK.
Andrianos M
AM
Yiorkas
Institute of Biomedicine, Biocenter Oulu, University of Oulu, Oulu, Finland.|Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland.
Karl-Heinz
KH
Herzig
Department of Health, National Institute for Health and Welfare, Helsinki, Finland.|Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.|Department of Obstetrics and Gynaecology, Oulu University Hospital and University of Oulu, Oulu, Finland.
Eero
E
Kajantie
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.|Department of Cardiology, Ealing Hospital, Middlesex, UK.
Weihua
W
Zhang
Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Sara M
SM
Willems
Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
Lars
L
Lannfelt
Section of Biology and Genetics, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Giovanni
G
Malerba
Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.|Department of Haematology, University of Cambridge, Cambridge, UK.|The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.
Nicole
N
Soranzo
Section of Biology and Genetics, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Elisabetta
E
Trabetti
University Medical Center Groningen, University of Groningen, Department of Cardiology, The Netherlands.|Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts, USA.|Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.
Niek
N
Verweij
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.|Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
Evangelos
E
Evangelou
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.|Farr Institute of Health Informatics Research, Institute of Health Informatics, University College London, London, UK.
Alireza
A
Moayyeri
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Anne-Claire
AC
Vergnaud
Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.|National Institute for Health Research Leicester Biomedical Research Unit in Cardiovascular Disease, Leicester, UK.
Christopher P
CP
Nelson
Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.|Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Bilbao, Spain.
Alaitz
A
Poveda
Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.
Tibor V
TV
Varga
University of Glasgow, Glasgow, UK.
Muriel
M
Caslake
Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.|Mr. De Craen suddenly passed away January 2016.
Anton Jm
AJ
de Craen
Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.|Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Stella
S
Trompet
Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Jian'an
J
Luan
Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Robert A
RA
Scott
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.|Centre for Genomic and Experimental Medicine, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Sarah E
SE
Harris
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.|Department of Psychology, University of Edinburgh, Edinburgh, UK.
David Cm
DC
Liewald
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.|Centre for Genomic and Experimental Medicine, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.|Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
Riccardo
R
Marioni
Department of Twin Research and Genetic Epidemiology, King's College London, UK.
Cristina
C
Menni
Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Aliki-Eleni
AE
Farmaki
Department of Biobank Research, Umeå University, Umeå, Sweden.
Göran
G
Hallmans
Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.|Department of Biobank Research, Umeå University, Umeå, Sweden.
Frida
F
Renström
Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.|National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA.
Jennifer E
JE
Huffman
Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Maija
M
Hassinen
Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Stephen
S
Burgess
National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA.|Section of Cardiology, Department of Medicine, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, USA.|Sections of Preventive Medicine and Epidemiology, Department of Medicine, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, USA.
Ramachandran S
RS
Vasan
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Janine F
JF
Felix
Development Management and Planning, Pfizer Worldwide Research and Development.
Maria
M
Uria-Nickelsen
Pfizer Worldwide Research and Development, Stockholm, Sweden.
Anders
A
Malarstig
Merck Research Laboratories, Genetics and Pharmacogenomics, Boston, Massachusetts, USA.
Dermot F
DF
Reily
Merck Research Laboratories, Cardiometabolic Disease, Kenilworth, New Jersey, USA.
Maarten
M
Hoek
Merck Research Laboratories, Cardiometabolic Disease, Kenilworth, New Jersey, USA.|CHDI Management/CHDI Foundation, Princeton, New Jersey, USA.
Thomas
T
Vogt
National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA.|Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
Honghuang
H
Lin
Institute of Epidemiology and Biobank Popgen, Kiel University, Kiel, Germany.
Wolfgang
W
Lieb
Neurology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Matthew
M
Traylor
Neurology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Hugh F
HF
Markus
University of North Carolina at Chapel Hill, Department of Epidemiology, Chapel Hill, North Carolina, USA.
Heather M
HM
Highland
University of North Carolina at Chapel Hill, Department of Epidemiology, Chapel Hill, North Carolina, USA.
Anne E
AE
Justice
Heart Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Eirini
E
Marouli
Department of Health, National Institute for Health and Welfare, Helsinki, Finland.
Jaana
J
Lindström
Department of Public Health and Clinical Nutrition, University of Eastern Finland, Finland.|Research Unit, Kuopio University Hospital, Kuopio, Finland.
Matti
M
Uusitupa
Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Pirjo
P
Komulainen
Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.|Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Finland.|Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.
Timo A
TA
Lakka
Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.|Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.
Rainer
R
Rauramaa
Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.|Faculty of Medicine, University of Split, Croatia.
Ozren
O
Polasek
Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Igor
I
Rudan
Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Olov
O
Rolandsson
Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.|Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.|Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.
Paul W
PW
Franks
Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
George
G
Dedoussis
Department of Twin Research and Genetic Epidemiology, King's College London, UK.
Timothy D
TD
Spector
Department of Health, National Institute for Health and Welfare, Helsinki, Finland.
Pekka
P
Jousilahti
Department of Health, National Institute for Health and Welfare, Helsinki, Finland.
Satu
S
Männistö
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.|Department of Psychology, University of Edinburgh, Edinburgh, UK.
Ian J
IJ
Deary
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.|Alzheimer Scotland Research Centre, University of Edinburgh, Edinburgh, UK.
John M
JM
Starr
Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Claudia
C
Langenberg
Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Nick J
NJ
Wareham
Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK.
Morris J
MJ
Brown
Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Anna F
AF
Dominiczak
Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
John M
JM
Connell
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.|The Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands.
J Wouter
JW
Jukema
Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Naveed
N
Sattar
University of Glasgow, Glasgow, UK.
Ian
I
Ford
University of Glasgow, Glasgow, UK.
Chris J
CJ
Packard
Estonian Genome Center, University of Tartu, Tartu, Estonia.|Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA.|Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.|Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts, USA.
Tõnu
T
Esko
Estonian Genome Center, University of Tartu, Tartu, Estonia.
Reedik
R
Mägi
Estonian Genome Center, University of Tartu, Tartu, Estonia.|Institute of Molecular and Cell Biology, Tartu, Estonia.
Andres
A
Metspalu
Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Rudolf A
RA
de Boer
Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Peter
P
van der Meer
Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.|Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.|Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands.
Pim
P
van der Harst
Division of Nephrology, Department of Internal Medicine and Medical Specialties, Columbus - Gemelli University Hospital, Catholic University, Rome, Italy.
Giovanni
G
Gambaro
Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.|Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA.
Erik
E
Ingelsson
Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Lars
L
Lind
Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.|Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Paul Iw
PI
de Bakker
Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.|Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Mattijs E
ME
Numans
Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark.|Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.
Ivan
I
Brandslund
Medical Department, Lillebaelt Hospital, Vejle, Denmark.
Cramer
C
Christensen
Department of Clinical Immunology and Biochemistry, Lillebaelt Hospital, Vejle, Denmark.
Eva Rb
ER
Petersen
South Ostrobothnia Central Hospital, Seinäjoki, Finland.
Eeva
E
Korpi-Hyövälti
Tampere University Hospital, Tampere, Finland.
Heikki
H
Oksa
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.|Department of Cardiology, Ealing Hospital, Middlesex, UK.|Imperial College Healthcare NHS Trust, London, UK.
John C
JC
Chambers
Department of Cardiology, Ealing Hospital, Middlesex, UK.|National Heart and Lung Institute, Imperial College London, London, UK.|Imperial College Healthcare NHS Trust, London, UK.
Jaspal S
JS
Kooner
Section of Investigative Medicine, Imperial College London, London, UK.|Department of Life Sciences, Brunel University London, London, UK.
Alexandra If
AI
Blakemore
Institute of Reproductive and Developmental Biology, Imperial College London, London, UK.
Steve
S
Franks
Department of Epidemiology and Biostatistics, Medical Research Council Public Health England Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London, St. Mary's Campus, London, UK.|Centre for Life Course Epidemiology, Faculty of Medicine, University of Oulu, Oulu, Finland.|Biocenter Oulu, University of Oulu, Oulu, Finland.|Unit of Primary Care, Oulu University Hospital, Oulu, Finland.
Marjo-Riitta
MR
Jarvelin
Research Centre for Prevention and Health, Capital Region of Denmark, Copenhagen, Denmark.
Lise L
LL
Husemoen
Research Centre for Prevention and Health, Capital Region of Denmark, Copenhagen, Denmark.|Department of Clinical Experimental Research, Glostrup University Hospital, Glostrup, Denmark.|Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Allan
A
Linneberg
Research Centre for Prevention and Health, Capital Region of Denmark, Copenhagen, Denmark.
Tea
T
Skaaby
Research Centre for Prevention and Health, Capital Region of Denmark, Copenhagen, Denmark.
Betina
B
Thuesen
Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.|National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital Trusts, Oxford, UK.
Fredrik
F
Karpe
Department of Health, National Institute for Health and Welfare, Helsinki, Finland.|Dasman Diabetes Institute, Dasman, Kuwait.|Centre for Vascular Prevention, Danube-University Krems, Krems, Austria.|King Abdulaziz University, Jeddah, Saudi Arabia.
Jaakko
J
Tuomilehto
Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
Alex Sf
AS
Doney
School of Molecular, Genetic and Population Health Sciences, University of Edinburgh, Medical School, Teviot Place, Edinburgh, UK.
Andrew D
AD
Morris
Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
Colin Na
CN
Palmer
HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.|St. Olav Hospital, Trondheim University Hospital, Trondheim, Norway.
Oddgeir Lingaas
OL
Holmen
HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.|Department of Medicine, Levanger Hospital, Nord- Trøndelag Health Trust, Levanger, Norway.
Kristian
K
Hveem
Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.|Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.|Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Cristen J
CJ
Willer
Folkhälsan Research Centre, Helsinki, Finland; Department of Endocrinology, Helsinki University Central Hospital, Helsinki, Finland.|Institute for Molecular Medicine Finland University of Helsinki, Helsinki, Finland.
Tiinamaija
T
Tuomi
Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.|Institute for Molecular Medicine Finland University of Helsinki, Helsinki, Finland.
Leif
L
Groop
Department of Primary Health Care, Vaasa Central Hospital, Vaasa, Finland.|Diabetes Center, Vaasa Health Care Center, Vaasa, Finland.
AnneMari
A
Käräjämäki
Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.|Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts, USA.|Institute for Molecular Medicine Finland University of Helsinki, Helsinki, Finland.|Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.
Aarno
A
Palotie
Institute for Molecular Medicine Finland University of Helsinki, Helsinki, Finland.|Department of Public Health, University of Helsinki, Finland.|Wellcome Trust Sanger Institute, Genome Campus, Hinxton, UK.
Samuli
S
Ripatti
Department of Health, National Institute for Health and Welfare, Helsinki, Finland.
Veikko
V
Salomaa
ICDDR, B; Mohakhali, Dhaka, Bangladesh.
Dewan S
DS
Alam
National Institute of Cardiovascular Diseases, Sher-e-Bangla Nagar, Dhaka, Bangladesh.
Abdulla Al
AA
Shafi Majumder
Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.|The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.
Emanuele
E
Di Angelantonio
Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Rajiv
R
Chowdhury
Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.|National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital Trusts, Oxford, UK.|Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Mark I
MI
McCarthy
International Centre for Circulatory Health, Imperial College London, UK.
Neil
N
Poulter
Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
Alice V
AV
Stanton
International Centre for Circulatory Health, Imperial College London, UK.
Peter
P
Sever
University of Lille, UMR1167, Risk Factors and Molecular Determinants of aging-related diseases, Lille, France.|Inserm, Lille, France.|Centre Hospitalier Universitaire Lille, Public Health, Lille, France.|Institut Pasteur de Lille, Lille, France.
Philippe
P
Amouyel
Department of Epidemiology and Public Health, EA 3430, University of Strasbourg, Strasbourg, France.
Dominique
D
Arveiler
Department of General and Interventional Cardiology, University Heart Center Hamburg, Germany.|University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Stefan
S
Blankenberg
Department of Epidemiology, UMR 1027- INSERM, Toulouse University-CHU Toulouse, Toulouse, France.
Jean
J
Ferrières
Director, UKCRC Centre of Excellence for Public Health, Queens University, Belfast, Northern Ireland.
Frank
F
Kee
Department of Health, National Institute for Health and Welfare, Helsinki, Finland.
Kari
K
Kuulasmaa
Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.|Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany.|DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
Martina
M
Müller-Nurasyid
Research Center in Epidemiology and Preventive Medicine, Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy.
Giovanni
G
Veronesi
Department of Health, National Institute for Health and Welfare, Helsinki, Finland.
Jarmo
J
Virtamo
Heart Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.|Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia.
Panos
P
Deloukas
Department of Epidemiology and Biostatistics, Medical Research Council Public Health England Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London, St. Mary's Campus, London, UK.
Paul
P
Elliott
Wellcome Trust Sanger Institute, Genome Campus, Hinxton, UK.
Eleftheria
E
Zeggini
Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.|Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.|Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.|Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts, USA.
Sekar
S
Kathiresan
University of Lund, Department of Clinical Sciences, Malmö, Sweden.
Olle
O
Melander
Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Johanna
J
Kuusisto
Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Markku
M
Laakso
Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Sandosh
S
Padmanabhan
Centre for Genomic and Experimental Medicine, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
David
D
Porteous
Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Caroline
C
Hayward
A Collaboration between the University Medical Schools and NHS, Aberdeen, Dundee, Edinburgh and Glasgow, UK.
Generation
G
Scotland
Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA.
Francis S
FS
Collins
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.
Karen L
KL
Mohlke
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Torben
T
Hansen
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Oluf
O
Pedersen
Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.|Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Michael
M
Boehnke
Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.|Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Heather M
HM
Stringham
Centre for Non-Communicable Diseases, Karachi, Pakistan.
Philippe
P
Frossard
Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.|Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Christopher
C
Newton-Cheh
Department of Health Sciences, University of Leicester, Leicester, UK.
Martin D
MD
Tobin
Department of Clinical Biochemistry Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark.
Børge Grønne
BG
Nordestgaard
Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK.|National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK.
Mark J
MJ
Caulfield
Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Anubha
A
Mahajan
Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.|Department of Biostatistics, University of Liverpool, Liverpool, UK.
Andrew P
AP
Morris
Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.|National Institute for Health Research Leicester Biomedical Research Unit in Cardiovascular Disease, Leicester, UK.|Institute of Cardiovascular Sciences, University of Manchester, Manchester, UK.
Maciej
M
Tomaszewski
Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.|National Institute for Health Research Leicester Biomedical Research Unit in Cardiovascular Disease, Leicester, UK.
Nilesh J
NJ
Samani
Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.|Centre for Non-Communicable Diseases, Karachi, Pakistan.|Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Danish
D
Saleheen
Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.|Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands.|Faculty of Population Health Sciences, Institute of Cardiovascular Science, University College London, London, UK.
Folkert W
FW
Asselbergs
The Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.|Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts, USA.|Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Cecilia M
CM
Lindgren
Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.|Wellcome Trust Sanger Institute, Hinxton, UK.|The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.
John
J
Danesh
Department of Health Sciences, University of Leicester, Leicester, UK.
Louise V
LV
Wain
Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.|The National Institute for Health Research Blood and Transplant Research.
Adam S
AS
Butterworth
Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Joanna Mm
JM
Howson
Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK.|National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK.
Patricia B
PB
Munroe
D001794:Blood Pressure / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*