Formulation and optimization of niosomes for topical diacerein delivery using 3-factor, 3-level Box-Behnken design for the management of psoriasis.
This research aimed towards the design of preparations of diacerein loaded cholesterol rich niosomes by employing a 3-factor, 3-level Box-Behnken design. Results indicated that Span 60 (90mg) and cholesterol (10mg), and 45min of hydration time were found to be optimum for niosomes preparation. The prepared cholesterol rich niosomes were uniform and spherical in size. Optimized formulation F2 entrapped the drug with 83.02% efficiency in the cholesterol rich niosomes of the size 477.8nm, presented the flux of 2.820μg/cm(2)/h, followed Higuchi model and non Fickian transport mechanism. The confocal laser scanning microscopy showed that niosomes accentuated the penetration of diacerein in the epidermal and dermal layer of rat skin. Stability study confirmed that cholesterol rich niosomes were stable for 2months at 4°C. Concisely, the results showed that targeted diacerein delivery might be achieved using topically applied niosomes for enhanced treatment of psoriasis, which might eliminate adverse side effects associated with systemic exposure.
Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), M. B. Road, New Delhi 110062, India.
Seyedeh Raziyeh Mahdavi
SR
Moghddam
Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. Electronic address: abdulahad20@yahoo.com.
Abdul
A
Ahad
Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), M. B. Road, New Delhi 110062, India. Electronic address: aqilmalik@yahoo.com.
Mohd
M
Aqil
Glocal School of Pharmacy, Glocal University, Saharanpur 247121, Uttar Pradesh, India.
Syed Sarim
SS
Imam
Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), M. B. Road, New Delhi 110062, India.
Yasmin
Y
Sultana
D000287:Administration, Topical; D000818:Animals; D000880:Anthraquinones / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D007700:Kinetics; D008081:Liposomes; D018613:Microscopy, Confocal; D010316:Particle Size; D010539:Permeability; D011565:Psoriasis / Q000188:drug therapy*; D051381:Rats; D012867:Skin / Q000187:drug effects
D000880:Anthraquinones; D008081:Liposomes; C025292:diacerein
Box-Behnken design; Diacerein; Niosomes; Psoriasis; Topical