ERBB4 gene polymorphisms and the risk of prostate cancer in a sample of Iranian Population.
Genetic polymorphisms in ERBB4 are thought to be associated with cancer susceptibility. In the present study, we aimed to assess the impact of ERBB4 rs12052398 T>C, rs13393577 A>G, rs13424871 A>T, rs16847082 A>G and rs6147150 (12-bp I/D) polymorphisms on risk of prostate cancer (PCa) in a sample of Iranian population. In a case-control study, we enrolled 169 patients with pathologically confirmed PCa and 182 subjects with benign prostatic hyperplasia (BPH). No significant association was found among ERBB4 polymorphisms and risk of PCa. Subjects carrying TT/AA/AA/AG/ID, TC/AA/AA/AA/II, TT/AA/AT/AA/II and TT/AA/AT/AG/ID genotypes are associated with a decreased risk of PCa. Our findings suggest that haplotypes CAAAI and TAAAD (rs12052398, rs13393577, rs13424871, rs16847082 and rs6147150I) of the ERBB4 polymorphisms are associated with a significantly lower risk of PCa. Further studies with a larger sample sizes and diverse ethnicities are necessary to verify our findings.
Zahedan University of Medical Sciences Cellular and Molecular Research Center Zahedan Iran mhd.hashemi@gmail.com.
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Hashemi
Zahedan University of Medical Sciences Department of Clinical Biochemistry, School of Medicine Zahedan Iran.
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Moradi
Zahedan University of Medical Sciences Department of Clinical Biochemistry, School of Medicine Zahedan Iran.
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Rezaei
Zahedan University of Medical Sciences Department of Clinical Biochemistry, School of Medicine Zahedan Iran.
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Sanaei
Shahid Beheshti University of Medical Sciences Urology and Nephrology Research Center, Department of Urology, Shahid Labbafinejad Medical Center Tehran Iran.
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Ziaee
Shahid Beheshti University of Medical Sciences Urology and Nephrology Research Center, Department of Urology, Shahid Labbafinejad Medical Center Tehran Iran.
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Narouie
Shahid Beheshti University of Medical Sciences Urology and Nephrology Research Center, Department of Urology, Shahid Labbafinejad Medical Center Tehran Iran.
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Sotoudeh
Zahedan University of Medical Sciences Department of Clinical Biochemistry, School of Medicine Zahedan Iran.
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Bahari
University of Manitoba Department of Human Anatomy& Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences Winnipeg Canada.
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Ghavami
D016022:Case-Control Studies; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics*; D066247:Receptor, ErbB-4 / Q000235:genetics*; D012307:Risk Factors
C587689:ERBB4 protein, human; D066247:Receptor, ErbB-4