The Influence of a Mouthpiece-Based Topography Measurement Device on Electronic Cigarette User's Plasma Nicotine Concentration, Heart Rate, and Subjective Effects Under Directed and Ad Libitum Use Conditions.
BACKGROUND
Electronic cigarettes e-cigarettes aerosolize a liquid solution often containing nicotine. e-cigarette nicotine delivery may be influenced by user puffing behaviors ("puff topography"). E-cigarette puff topography can be recorded using mouthpiece-based computerized systems. The present study sought to examine the extent to which these systems influence e-cigarette nicotine delivery and other e-cigarette associated acute effects under ad libitum use conditions.


METHODS
Plasma nicotine concentration, heart rate, and subjective effects were assessed in 29 experienced e-cigarette users using their preferred e-cigarette battery and liquid (≥12mg/mL nicotine) in two sessions differing only by the presence of a mouthpiece-based device. In both sessions, participants completed a directed e-cigarette use bout (10 puffs, 30-s interpuff interval) and a 90-min ad libitum bout. Puff topography was recorded in the session with the topography mouthpiece.


RESULTS
Plasma nicotine, heart rate, and subjective effects, aside from "Did the e-cigarette Taste Good?" were independent of topography measurement (higher mean taste ratings were observed in the no topography condition). Mean (SEM) plasma nicotine concentration following the ad libitum bout was 34.3ng/mL (4.9) in the no topography condition and 35.7ng/mL (4.3) in the topography condition. Longer puff durations, longer interpuff intervals, and larger puff volumes were observed in the ad libitum relative to the directed bout.


CONCLUSIONS
E-cigarette use significantly increased plasma nicotine concentration and heart rate while suppressing abstinence symptoms. These effects did not differ when a topography mouthpiece was present. Future studies using ad libitum e-cigarette use bouts would facilitate understanding of e-cigarette toxicant yield.


CONCLUSIONS
No prior study has examined whether mouthpiece-based topography recording devices influence e-cigarette associated nicotine delivery, heart rate, or subjective effects under ad libitum conditions or assessed ad libitum puff topography in experienced individuals using their preferred e-cigarette battery and liquid with a mouthpiece-based computerized device. E-cigarette use significantly increased plasma nicotine concentration and heart rate while suppressing abstinence symptoms. These effects did not differ when a topography mouthpiece was present. Ad libitum puff topography differed from puff topography recorded during directed puffing. These findings suggest that future studies using ad libitum use bouts would facilitate better understanding of e-cigarette toxicant yield.
Center for the Study of Tobacco Products, Department of Psychology, Virginia Commonwealth University, Richmond, VA.
Tory R
TR
Spindle
Center for the Study of Tobacco Products, Department of Psychology, Virginia Commonwealth University, Richmond, VA.
Marzena M
MM
Hiler
Center for the Study of Tobacco Products, Department of Psychology, Virginia Commonwealth University, Richmond, VA.
Alison B
AB
Breland
Center for the Study of Tobacco Products, Department of Psychology, Virginia Commonwealth University, Richmond, VA.|Department of Mechanical Engineering, American University of Beirut, Beirut, Lebanon.
Nareg V
NV
Karaoghlanian
Center for the Study of Tobacco Products, Department of Psychology, Virginia Commonwealth University, Richmond, VA.|Department of Mechanical Engineering, American University of Beirut, Beirut, Lebanon.
Alan L
AL
Shihadeh
Center for the Study of Tobacco Products, Department of Psychology, Virginia Commonwealth University, Richmond, VA.
Thomas
T
Eissenberg
D066300:Electronic Nicotine Delivery Systems; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008991:Monitoring, Physiologic / Q000295:instrumentation*; D009538:Nicotine / Q000097:blood / Q000494:pharmacology
D009538:Nicotine