Time to viral clearance after successful conservative treatment for high-risk HPV-infected high-grade cervical intraepithelial neoplasia and early invasive squamous cervical carcinoma.
Two-thirds of 152 patients treated for high-grade cervical disease, free of persistence/recurrence, and followed-up both with human papillomavirus (HPV) DNA testing and HPV genotyping cleared their high-risk HPV infection within 1year. Viral clearance continued at diminishing rates during the second and the third year, at the end of which it was virtually complete.
Unit of Microbiology, Department of Diagnostic Medicine and Prevention (DAI-MDP), St Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Simona
S
Venturoli
Department of Obstetrics and Gynaecology, St Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Silvano
S
Costa
Unit of Microbiology, Department of Diagnostic Medicine and Prevention (DAI-MDP), St Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Daniela
D
Barbieri
Department of Obstetrics and Gynaecology, St Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Adriana
A
Falasca
Department of Obstetrics and Gynaecology, St Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Elena
E
Marra
Department of Obstetrics and Gynaecology, St Anna Hospital, University of Ferrara, Ferrara, Italy.
Paola
P
Garutti
Unit of Microbiology, Department of Diagnostic Medicine and Prevention (DAI-MDP), St Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.
Maria Paola
MP
Landini
Department of Health, Emilia-Romagna Region, Bologna, Italy.
Stefano
S
Ferretti
Romagna Cancer Registry, Romagna Cancer Institute (IRST) IRCCS, Meldola, Forlì, Italy. Electronic address: lauro.bucchi@irst.emr.it.
Lauro
L
Bucchi
D000328:Adult; D002277:Carcinoma / Q000188:drug therapy* / Q000821:virology*; D000072700:Conservative Treatment / Q000379:methods; D005260:Female; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification*; D013997:Time Factors; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000821:virology*; D055815:Young Adult
Cervical cancer; Cervical intraepithelial neoplasia; Follow-up; Genotyping; Human papillomavirus; Viral clearance