Replicating Cardiovascular Condition-Birth Month Associations.
Independent replication is vital for study findings drawn from Electronic Health Records (EHR). This replication study evaluates the relationship between seasonal effects at birth and lifetime cardiovascular condition risk. We performed a Season-wide Association Study on 1,169,599 patients from Mount Sinai Hospital (MSH) to compute phenome-wide associations between birth month and CVD. We then evaluated if seasonal patterns found at MSH matched those reported at Columbia University Medical Center. Coronary arteriosclerosis, essential hypertension, angina, and pre-infarction syndrome passed phenome-wide significance and their seasonal patterns matched those previously reported. Atrial fibrillation, cardiomyopathy, and chronic myocardial ischemia had consistent patterns but were not phenome-wide significant. We confirm that CVD risk peaks for those born in the late winter/early spring among the evaluated patient populations. The replication findings bolster evidence for a seasonal birth month effect in CVD. Further study is required to identify the environmental and developmental mechanisms.
Dept of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1498, New York, NY 10029, USA.|Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1498, New York, NY 10029, USA.
Li
L
Li
Dept of Biomedical Informatics, Columbia University Medical Center, 622 West 168th Street, PH-20, New York, NY, USA.|Dept of Systems Biology, Columbia University Medical Center, 622 West 168th Street, PH-20, New York, NY, USA.|Dept of Medicine, Columbia University Medical Center, 622 West 168th Street, PH-20, New York, NY, USA.|Observational Health Data Sciences and Informatics, Columbia University Medical Center, 622 West 168th Street, PH-20, New York, NY, USA.
Mary Regina
MR
Boland
Dept of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1498, New York, NY 10029, USA.|Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1498, New York, NY 10029, USA.
Riccardo
R
Miotto
Dept of Biomedical Informatics, Columbia University Medical Center, 622 West 168th Street, PH-20, New York, NY, USA.|Dept of Systems Biology, Columbia University Medical Center, 622 West 168th Street, PH-20, New York, NY, USA.|Dept of Medicine, Columbia University Medical Center, 622 West 168th Street, PH-20, New York, NY, USA.|Observational Health Data Sciences and Informatics, Columbia University Medical Center, 622 West 168th Street, PH-20, New York, NY, USA.
Nicholas P
NP
Tatonetti
Dept of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1498, New York, NY 10029, USA.|Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1498, New York, NY 10029, USA.
Joel T
JT
Dudley
D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D016208:Databases, Factual; D057286:Electronic Health Records; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D036801:Parturition; D012307:Risk Factors; D012621:Seasons