Neurological Disease as a Failure of Brain-Immune Crosstalk: The Multiple Faces of Neuroinflammation.
Neuroinflammation is common to various diseases of the central nervous system (CNS), but its imprecise definition has led to many misconceptions in research and clinical approaches. It is now recognized that neuroinflammation in chronic neurodegenerative conditions, including Alzheimer's disease (AD) and age-related dementia, is distinct from the inflammation that accompanies relapsing-remitting multiple sclerosis (RRMS), and its experimental animal model, experimental autoimmune encephalomyelitis (EAE). Here, we discuss the discrete features of inflammation in different CNS pathologies, given the current understanding of the CNS-immune crosstalk; the roles of the immune cells that are involved, their phenotypes, and their location and route of entry to the CNS. Understanding the term neuroinflammation to encompass a broad range of disease-specific conditions is essential for finding effective therapeutic approaches for these pathologies.
Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: Michal.Schwartz@weizmann.ac.il.
Michal
M
Schwartz
Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Aleksandra
A
Deczkowska
D000544:Alzheimer Disease / Q000276:immunology*; D000818:Animals; D001921:Brain / Q000276:immunology*; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D006801:Humans; D007107:Immune System; D007372:Interferons / Q000378:metabolism; D051379:Mice; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000276:immunology*; D020078:Neurogenic Inflammation; D015213:Neuroimmunomodulation
D007372:Interferons
Alzheimer's disease; CNS immune surveillance; choroid plexus; interferon; multiple sclerosis; neurodegenerative disease