Infantile hemangiomas and structural anomalies: PHACE and LUMBAR syndrome.
In a subset of patients, infantile hemangiomas may be associated with structural anomalies. Structural anomalies may affect the upper body (PHACE Syndrome) or the lower body (LUMBAR Syndrome). Since their initial descriptions, improved understanding of these two syndromes has lead to recognition of a broader phenotypic spectrum than initially recognized. This paper aims to provide an updated review of the presentation, associated anomalies, and management of PHACE and LUMBAR syndromes, two well-characterized syndromes associated with IH.
Department of Dermatology, University of Southern California, Los Angeles, California, USA. mluu@chla.usc.edu.
Minnelly
M
Luu
Department of Dermatology, University of California San Francisco, San Francisco, California, USA.
Ilona J
IJ
Frieden
D000015:Abnormalities, Multiple / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D005153:Facial Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D006391:Hemangioma / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007223:Infant; D012878:Skin Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D013577:Syndrome
LUMBAR Syndrome; PHACE Syndrome; infantile hemangioma; structural anomalies