[Protein-repellent and antibacterial properties of modified orthodontic adhesive].
OBJECTIVE
To develop a novel protein-repellent orthodontic adhesive by incorporating 2-methacryloyloxyethyl phosphorylcholine(MPC).


METHODS
MPC was incorporated into a commercially available orthodontic adhesive(Fuji ORTHO) at 0% (control), 1.5%, 3.0%, and 5.0% by mass. Enamel shear bond strength(SBS) was determined. Protein adsorption onto specimens was determined by a micro bicinchoninic acid method. A dental plaque microcosm biofilm model with human saliva as inoculum was used to investigate biofilm viability.


RESULTS
The SBS was not reduced in the group(3.0% MPC), compared to the control group. The amount of protein adsorption in the group(3.0% MPC) was (0.46±0.06) μg/cm(2) and (4.57 ± 0.42) μg/cm(2) in the control group. Lactic acid production of biofilms in the group(3.0% MPC) was (7.12±1.03) mmol/L and (12.16±1.24) mmol/L in the control group.


CONCLUSIONS
MPC based orthodontic adhesive greatly reduced the protein adsorption and bacterial adhesion, without compromising enamel shear bond strength.
Department of Orthodontics, Capital Medical University School of Stomatology, Beijing 100050, China.
N
N
Zhang
Department of Orthodontics, Capital Medical University School of Stomatology, Beijing 100050, China.
Y S
YS
Ma
Biomaterials & Tissue Engineering Division, University of Maryland Dental School, Baltimore, MD 21201, U S A.
H K
HK
Xu
Department of Orthodontics, Capital Medical University School of Stomatology, Beijing 100050, China.
Y X
YX
Bai
D000327:Adsorption; D000900:Anti-Bacterial Agents; D001422:Bacterial Adhesion; D018441:Biofilms; D001840:Dental Bonding; D003738:Dental Cements / Q000737:chemistry*; D003743:Dental Enamel; D003773:Dental Plaque; D019344:Lactic Acid; D008689:Methacrylates; D016910:Orthodontic Brackets; D010767:Phosphorylcholine / Q000031:analogs & derivatives; D011506:Proteins; D019279:Resin Cements; D012463:Saliva; D033081:Shear Strength
D000900:Anti-Bacterial Agents; D003738:Dental Cements; D008689:Methacrylates; D011506:Proteins; D019279:Resin Cements; D010767:Phosphorylcholine; D019344:Lactic Acid; C070638:2-methacryloyloxyethyl phosphorylcholine