An association between newly diagnosed cutaneous T cell lymphoma and prior impetigo: a nested case-control study.
Colonization with staphylococcus aureus (SA) is associated with disease activity and progression in patients with cutaneous T-cell lymphoma (CTCL) secondary to T-cell activation by bacterial superantigens. The aim of the current study was to evaluate the possible role of SA as an etiologic factor affecting CTCL initiation. We conducted a nested case-control study in a large population-representative database from the UK. Cases were defined as all patients with an incident diagnosis of mycosis fungoides (MF) or Sezary syndrome (SS) between 1995 and 2013. For every case, four eligible controls matched on age, sex, practice-site, and duration of follow-up were selected. Exposure of interest was clinical diagnosis of impetigo prior to CTCL diagnosis. Conditional logistic regression was used to calculate odds-ratio (ORs) and 95 % confidence-interval (CI) for CTCL risk. The results were further stratified according to age, sex and time interval between impetigo and CTCL diagnosis. The study population included 310 cases with MF or SS and 1223 matched controls. Among cases with CTCL 4.8 % (n = 15) had impetigo prior to cancer diagnosis compared to 2 % (n = 24) of controls. The adjusted OR for CTCL diagnosis among patients with prior impetigo was 2.33 (95 % CI 1.12-4.83). The risk was elevated among individuals with impetigo 1-5 years before cancer diagnosis (OR 3.33, 95 % CI 1.00-11.10). There was no change in risk among patients with impetigo more than 5 years before cancer diagnosis (OR 1.09, 95 % CI 0.35-3.37). Our results suggest a possible association between SA colonization and CTCL initiation that might serve as an important etiological factor for the disease.
Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.|Department of Epidemiology and Biostatistics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, USA.|Tel-Aviv University, Tel-Aviv, Israel.
Ben
B
Boursi
Clinical Epidemiology, HealthCore, Wilmington, DE, USA.
Kevin
K
Haynes
Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.|Department of Epidemiology and Biostatistics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, USA.
Ronac
R
Mamtani
Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. yangy@mail.med.upenn.edu.|Department of Epidemiology and Biostatistics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, USA. yangy@mail.med.upenn.edu.
Yu-Xiao
YX
Yang
D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007169:Impetigo / Q000150:complications* / Q000382:microbiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors; D012751:Sezary Syndrome / Q000209:etiology*; D012878:Skin Neoplasms / Q000209:etiology*; D013211:Staphylococcus aureus / Q000302:isolation & purification; D013997:Time Factors; D006113:United Kingdom
CTCL; Impetigo; Mycosis fungoides; Risk; Sezary syndrome; Superantigen