Traumatic brain injury and subsequent glioblastoma development: Review of the literature and case reports.
BACKGROUND
Previous reports have proposed an association between traumatic brain injury (TBI) and subsequent glioblastoma (GBM) formation.


METHODS
We used literature searches and radiographic evidence from two patients to assess the possibility of a link between TBI and GBM.


RESULTS
Epidemiological studies are equivocal on a possible link between brain trauma and increased risk of malignant glioma formation. We present two case reports of patients with GBM arising at the site of prior brain injury.


CONCLUSIONS
The hypothesis that TBI may predispose to gliomagenesis is disputed by several large-scale epidemiological studies, but supported by some. Radiographic evidence from two cases presented here suggest that GBM formed at the site of brain injury. We propose a putative pathogenesis model that connects post-traumatic inflammation, stem and progenitor cell transformation, and gliomagenesis.
Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT, USA.
Vineet
V
Tyagi
Department of Neurosurgery, NYU School of Medicine, Brooklyn, New York, USA.
Jason
J
Theobald
Department of Neurosurgery, NYU School of Medicine, Brooklyn, New York, USA.
James
J
Barger
Department of Neurosurgery, NYU School of Medicine, Brooklyn, New York, USA.
Mark
M
Bustoros
Department of Neurosurgery, NYU School of Medicine, Brooklyn, New York, USA; Kimmel Center for Stem Cell Biology, NYU School of Medicine, Brooklyn, New York, USA.
N Sumru
NS
Bayin
Department of Neurosurgery, NYU School of Medicine, Brooklyn, New York, USA.
Aram S
AS
Modrek
Department of Neurosurgery, NYU School of Medicine, Brooklyn, New York, USA.
Michael
M
Kader
Division of Neurosurgery, Maimonides Medical Center, Brooklyn, New York, USA.
Erich G
EG
Anderer
Department of Radiation Oncology, NYU School of Medicine, Brooklyn, New York, USA; Maimonides Cancer Center, Brooklyn, New York, USA.
Bernadine
B
Donahue
Department of Radiology, NYU School of Medicine, Brooklyn, New York, USA.
Girish
G
Fatterpekar
Department of Neurosurgery, NYU School of Medicine, Brooklyn, New York, USA; Kimmel Center for Stem Cell Biology, NYU School of Medicine, Brooklyn, New York, USA; Brain Tumor Center, NYU School of Medicine, Brooklyn, New York, USA.
Dimitris G
DG
Placantonakis
Brain tumor; glioblastoma; traumatic brain injury