Two new phenolic compounds and antitumor activities of asparinin A from Asparagus officinalis.
Two new phenolic acid compounds, asparoffin C (1) and asparoffin D (2), together with four known compounds, asparenyol (3), gobicusin B (4), 1-methoxy-2-hydroxy-4-[5-(4-hydroxyphenoxy)-3-penten-1-ynyl] phenol (5), and asparinin A (6), have been isolated from the stems of Asparagus officinalis. The structures were established by extensive spectroscopic methods (MS and 1D and 2D NMR). Compound 6 has obvious antitumor activities both in vitro and in vivo.
a College of Pharmacy , South-Central University for Nationalities , Wuhan 430074 , China.|b School of Agriculture and Biological Technique , Yunnan Agricultural University , Kunming 650201 , China.
Xue-Mei
XM
Li
a College of Pharmacy , South-Central University for Nationalities , Wuhan 430074 , China.
Jin-Long
JL
Cai
a College of Pharmacy , South-Central University for Nationalities , Wuhan 430074 , China.
Le
L
Wang
a College of Pharmacy , South-Central University for Nationalities , Wuhan 430074 , China.
Wen-Xiang
WX
Wang
a College of Pharmacy , South-Central University for Nationalities , Wuhan 430074 , China.
Hong-Lian
HL
Ai
b School of Agriculture and Biological Technique , Yunnan Agricultural University , Kunming 650201 , China.
Zi-Chao
ZC
Mao
D000480:Alkynes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D027761:Asparagus Plant / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000480:Alkynes; D010636:Phenols; C000616020:asparoffin C; C000616021:asparoffin D
Asparagus officinalis; antitumor; asparinin A; phenolic compounds