Methylglyoxal as a scavenger for superoxide anion-radical.
Methylglyoxal at a concentration of 5 mM caused a significant inhibition of superoxide anion radical (O2 (·-)) comparable to the effect of Tirone. In the process of O2 (·-) generation in the system of egg phosphatidylcholine liposome peroxidation induced by the azo-initiator AIBN, a marked inhibition of chemiluminescence in the presence of 100 mM methylglyoxal was found. At the same time, methylglyoxal did not inhibit free radical peroxidation of low-density lipoprotein particles, which indicates the absence of interaction with methylglyoxal alkoxyl and peroxyl polyenoic lipid radicals. These findings deepen information about the role of methylglyoxal in the regulation of free radical processes.
Bach Institute of Biochemistry, Federal Research Center "Fundamentals of Biotechnology,", Russian Academy of Sciences, Leninskii pr. 33, Moscow, 119071, Russia. gavakon5050@mail.ru.
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KB
Shumaev
Russian Cardiology Research and Production Association, Ministry of Public Health of the Russian Federation, 3-ya Cherepkovskaya ul. 15a, Moscow, 121552, Russia.
V Z
VZ
Lankin
Russian Cardiology Research and Production Association, Ministry of Public Health of the Russian Federation, 3-ya Cherepkovskaya ul. 15a, Moscow, 121552, Russia.
G G
GG
Konovalova
Russian Cardiology Research and Production Association, Ministry of Public Health of the Russian Federation, 3-ya Cherepkovskaya ul. 15a, Moscow, 121552, Russia.
M A
MA
Grechnikova
Russian Cardiology Research and Production Association, Ministry of Public Health of the Russian Federation, 3-ya Cherepkovskaya ul. 15a, Moscow, 121552, Russia.
A K
AK
Tikhaze
D004527:Egg Proteins / Q000737:chemistry; D016166:Free Radical Scavengers / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008077:Lipoproteins, LDL / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry; D008163:Luminescent Measurements; D008956:Models, Chemical; D009570:Nitriles / Q000494:pharmacology; D010713:Phosphatidylcholines / Q000737:chemistry; D011765:Pyruvaldehyde / Q000494:pharmacology*; D013481:Superoxides / Q000737:chemistry*
D004527:Egg Proteins; D016166:Free Radical Scavengers; D008077:Lipoproteins, LDL; D008081:Liposomes; D009570:Nitriles; D010713:Phosphatidylcholines; D013481:Superoxides; D011765:Pyruvaldehyde; C004526:azobis(isobutyronitrile)