Application of bioimpedance spectroscopy in Asian dialysis patients (ABISAD-III): a randomized controlled trial for clinical outcomes.
OBJECTIVE
Fluid management with body composition monitor based on bioimpedance spectroscopy (BCM-BIS) has been found to be beneficial for dialysis patients. We conducted a study to provide an algorithm for the determination of post-dialysis target weight (PDTW) and to evaluate whether this approach could improve clinical outcomes compared to patients who had PDTW decided clinically.


METHODS
Two hundred and ninety-eight dialysis patients participated in this 1-year randomized controlled trial. The outcomes were all-cause hospitalization rate, AFO or CV-related events, hypertension and intra-dialysis morbidities.


RESULTS
80 % of post-dialysis weight reached the target set with current algorithm. All-cause hospitalization rate was not different. Incidence of acute fluid overload (AFO) or CV-related events was lower in study group. Longitudinal data showed decreased incidence of hypertension, intra-dialysis morbidities and intra-dialysis hypotension.


CONCLUSIONS
Assessment of PDTW by BCM-BIS with an explicit algorithm decreased AFO or CV-related events, hypertension and intra-dialysis morbidities. Further studies were required to demonstrate possible benefits of hospitalization rate.
An Hsin QingShui Clinic, Taichung, Taiwan.
Chen
C
Huan-Sheng
Sheng An Clinic, Yunlin, Taiwan.
Chang
C
Yeong-Chang
Dialysis Center, Fu Ping Hospital, Taichung, Taiwan.
Hsieh
H
Ming-Hsing
Dialysis Center, Fu Ping Hospital, Taichung, Taiwan.
Tseng
T
Fan-Lieh
Dialysis Center, Yuan Lin Ho's Hospital, Changhua, Taiwan.
Lin
L
Chu-Cheng
Department of Nephrology, Tungs' Taichung MetroHarbor Hospital, No. 699, Sec.1, Chungchi Rd., Wuchi Dist., Taichung City, 43503, Taiwan.
Wu
W
Tsai-Kun
Department of Nephrology, Tungs' Taichung MetroHarbor Hospital, No. 699, Sec.1, Chungchi Rd., Wuchi Dist., Taichung City, 43503, Taiwan.
Chen
C
Hung-Ping
Dialysis Center, Tseng Han Chi Hospital, Nantou, Taiwan.
Hung
H
Sze-Hung
An Hsin Chushan Clinic, Nantou, Taiwan.
Chiu
C
Hsien-Chang
Sheng An Clinic, Yunlin, Taiwan.
Lee
L
Chia-Chen
Department of Nephrology, Min-Sheng General Hospital, Taoyuan, Taiwan.
Hou
H
Chun-Cheng
Department of Nephrology, Saint Paul's Hospital, Taoyuan, Taiwan.
Cheng
C
Chun-Ting
Dialysis Center, Hsin-Jen Hospital, Taipei, Taiwan.
Liou
L
Hung-Hsiang
School of Medicine, China Medical University, Taichung, Taiwan.
Lin
L
Chun-Ju
Department of Nephrology, Tungs' Taichung MetroHarbor Hospital, No. 699, Sec.1, Chungchi Rd., Wuchi Dist., Taichung City, 43503, Taiwan. jamespslim@gmail.com.
Lim
L
Paik-Seong
D000368:Aged; D000465:Algorithms; D044466:Asian People; D001823:Body Composition; D001826:Body Fluids; D001835:Body Weight; D017097:Electric Impedance; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007022:Hypotension / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D006435:Renal Dialysis / Q000009:adverse effects* / Q000379:methods; D012815:Signal Processing, Computer-Assisted; D013624:Taiwan; D013997:Time Factors
Bioimpedance spectroscopy; Body composition monitor; Hemodialysis; Intra-dialysis morbidities