Report: Protective effects of rice bran oil in haloperidol-induced tardive dyskinesia and serotonergic responses in rats.
Effect of administration of Rice bran oil (RBO) was evaluated on haloperidol elicited tardive dyskinesia in rats. Albino Wistar rats treated with haloperidol in drinking water at a dose of 0.2mg/kg/day and RBO by oral tubes at a dose of 0.4 mL/day for 5 weeks. Motor coordination, VCMs and 8-hydroxy-2-(di-n-propylamino) tetraline)[8-OH-DPAT] _syndrome were monitored. Striatal serotonin (5-hydroxytryptamine; 5-HT) and 5-hydroxyindolacetic acid (5-HIAA) levels were determined by high performance liquid chromatography (HPLC-EC). Rats treated with haloperidol orally at a dose of for a period of 5 weeks developed VCMs, which increased progressively as the treatment continued for 5 weeks. Motor coordination impairment started after the 1st week and was maximally impaired after 3 weeks and gradually returned to the 1st week value. Co-administration of RBO prevented haloperidol_induced VCMs as well impairment of motor coordination. The intensity of 8-OH-DPAT_induced syndrome and decreased 5-HT metabolism were greater in water + haloperidol treated animals than RBO + haloperidol treated animals. The present study suggested that involvement of free radical in the development of TD and point to RBO as a possible therapeutic option to treat this hyperkinetic motor disorder.
Department of Biochemistry, Bahauddin Zakariya University, Multan, Pakistan.
Noreen
N
Samad
Department of Biomedical Engineering, Sir Syed University of Engineering and Technology, Karachi, Pakistan.
Muhammad Abdul
MA
Haleem
Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine & Drug Research, UOK, Karachi, Pakistan.
Darakhshan Jabeen
DJ
Haleem
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000378:metabolism; D000818:Animals; D014150:Antipsychotic Agents / Q000009:adverse effects*; D020820:Dyskinesias / Q000517:prevention & control; D006220:Haloperidol / Q000009:adverse effects*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D010938:Plant Oils / Q000627:therapeutic use*; D004856:Postural Balance / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D000073879:Rice Bran Oil; D012701:Serotonin / Q000378:metabolism*; D000071057:Tardive Dyskinesia / Q000517:prevention & control*
D014150:Antipsychotic Agents; D018696:Neuroprotective Agents; D010938:Plant Oils; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D006220:Haloperidol; D000073879:Rice Bran Oil