Imaging features of renal complications after crizotinib treatment for non-small-cell lung cancer: a case report.
Crizotinib has been approved for the treatment of advanced ALK-positive non-small cell lung cancer. Its use is associated with the development of complex renal cysts. However, there is limited literature regarding imaging features of renal cystic disease during crizotinib therapy and its complications or progression. Here, we describe a case of a patient with ALK-positive advanced non-small cell lung cancer who developed complex renal cyst during crizotinib treatment. The renal cyst is complicated by infection and abscess formation. Subsequent renal biopsy, antibiotics treatment, and open drainage of loculated renal abscess showed no malignant cells and contributed to the diagnosis. The imaging features should be recognized as renal cystic disease of crizotinib treatment and not to be mistaken as new metastasis and disease progression.
Division of Oncologic Imaging, National Cancer Centre, 11 Hospital Drive, 169610 Singapore.
Wan Ying
WY
Chan
Division of Medical Oncology, National Cancer Centre, Singapore.
Mei-Kim
MK
Ang
Division of Medical Oncology, National Cancer Centre, Singapore.
Daniel Shao Weng
DS
Tan
Asiamedic Limited, Singapore.
Wan Lin
WL
Koh
Division of Oncologic Imaging, National Cancer Centre, 11 Hospital Drive, 169610 Singapore.
Jin Wei
JW
Kwek
ALK inhibitor; Crizotinib; Non–small cell lung cancer; Renal cysts