Disease Tolerance Trick or Treat: Give Your Brain Something Good to Eat.
The reprioritization of feeding motivations during disease is proposed to optimize host defense strategies against infection. Now, Wang et al. identify that sickness-induced anorexia differentially shapes the metabolic requirements of cellular stress adaptations, leading to opposite impact on disease tolerance upon bacterial versus viral infections.
Nomis Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: jayres@salk.edu.
Janelle S
JS
Ayres
D000855:Anorexia / Q000382:microbiology*; D001921:Brain; D004361:Drug Tolerance; D006801:Humans; D007108:Immune Tolerance; D014777:Virus Diseases