A lysosome-targeted fluorescent sensor for the detection of glutathione in cells with an extremely fast response.
A highly sensitive and selective Rhodamine B-based fluorescent sensor, RhB-1, for glutathione (GSH) was easily synthesized. An extremely fast detection response time of 10 s, which is the fastest one ever reported, is achieved in aqueous solutions over a wide pH range with large enhancement of emission intensity. The sensor detects GSH in cells and selectively accumulates in lysosomes.
State Key Laboratory of Virology, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China. fljiang@whu.edu.cn yiliuchem@whu.edu.cn.
Rong
R
Huang
Bei-Bei
BB
Wang
Xing-Ming
XM
Si-Tu
Tao
T
Gao
Fang-Fang
FF
Wang
Huan
H
He
Xiao-Yang
XY
Fan
Feng-Lei
FL
Jiang
Yi
Y
Liu