The ever-expanding myokinome: discovery challenges and therapeutic implications.
Exercise reduces the risk of a multitude of disorders, from metabolic disease to cancer, but the molecular mechanisms mediating the protective effects of exercise are not completely understood. The realization that skeletal muscle is an endocrine organ capable of secreting proteins termed 'myokines', which participate in tissue crosstalk, provided a critical link in the exercise-health paradigm. However, the myokine field is still emerging, and several challenges remain in the discovery and validation of myokines. This Review considers these challenges and highlights some recently identified novel myokines with the potential to be therapeutically exploited in the treatment of metabolic disease and cancer.
Cellular &Molecular Metabolism Laboratory, Diabetes &Metabolism Division, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia.
Martin
M
Whitham
Cellular &Molecular Metabolism Laboratory, Diabetes &Metabolism Division, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia.
Mark A
MA
Febbraio
D000818:Animals; D055808:Drug Discovery / Q000379:methods* / Q000639:trends; D015444:Exercise / Q000502:physiology*; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D008659:Metabolic Diseases / Q000188:drug therapy / Q000378:metabolism; D009124:Muscle Proteins / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism*; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism
C508600:IL6 protein, human; D015850:Interleukin-6; D009124:Muscle Proteins