Cytotoxic limonoids from the root bark of Dictamnus angustifolius.
Three novel limonoids, dictangustone G (1), dictangustone H (2), and dictangustone I (3) were isolated from the root bark of Dictamnus angustifolius. Their structures were elucidated on the basis of detailed spectroscopic analysis including UV, IR, HRESIMS, 1D and 2D NMR spectroscopic experiments. Compounds 1-3 were evaluated for their cytotoxic activities using Hela, A549, MCF7, and LN229 cell lines.
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Jian-Bo
JB
Sun
Department of Medical Science, Shunde Polytechnic College, Shunde, Guangdong 528333, China.
Ben-Qin
BQ
Tang
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Qiangqiang
Q
Li
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Bing
B
Wang
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China. Electronic address: jyliang08@126.com.
Jing-Yu
JY
Liang
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China. Electronic address: chenli627@cpu.edu.cn.
Li
L
Chen
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor; D036905:Dictamnus / Q000737:chemistry*; D006801:Humans; D036701:Limonins / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D036701:Limonins
Cytotoxic activities; Dictamnus angustifolius; Limonoids