Epidemiology of Barrett's esophagus and esophageal adenocarcinoma in Spain. A unicentric study.
BACKGROUND
Barrett's esophagus (BE) is an acquired disease defined by the presence of intestinal metaplasia with goblet cells in the distal esophagus. The prevalence of BE has increased dramatically over the last years.


OBJECTIVE
The primary aims of the study were to analyze the characteristics of BE and esophageal adenocarcinoma (EAC) in a Spanish health district during a follow-up period.


METHODS
Sociodemographic factors, alcohol consumption and cigarette smoking were analyzed. We also studied the histological behavior and cause of death in each group.


RESULTS
In the present study 430 patients were included, 338 with BE and 92 with EAC. Incidence rates have risen from 2.25 and 1.25 per 100,000 inhabitants in 1996 to 6.5 and 4.75 per 100,000 in 2011, respectively. In the EAC group, male gender, age and alcohol consumption were higher in comparison to the BE group, and the overall survival was 23 months. In the BE group, the main causes of death were non-esophageal cancer and cardiovascular disease.


CONCLUSIONS
The incidence and prevalence rates of AEC and BE have risen over the past years. Risk factors for these conditions were male gender, age and alcohol consumption. Long BE (> 3 cm) is involved in dysplasia progression. AEC diagnosis mainly occurs after neoplasia is detected and, in a few cases, due to a previous BE. Cardiovascular diseases and non-esophageal cancers have been found to be the main cause of death in BE patients.
UGC Intercentros de Aparato Digestivo, HUVM, españa.
Quetzalihuitl
Q
Arroyo-Martínez
UGC Intercentros de Aparato Digestivo , HUVM.
Manuel
M
Rodríguez-Téllez
Departamento de Anatomía Patológica, HUVM.
Antonio
A
García-Escudero
Departamento de Anatomía Patológica, HUVM.
Javier
J
Brugal-Medina
Departamento de Anatomía Patológica, HUVM.
Ricardo
R
González-Cámpora
Aparato Digestivo, Hospital Universitario Virgen Macarena, España.
Ángel
Á
Caunedo Álvarez
D000230:Adenocarcinoma / Q000453:epidemiology*; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking; D001471:Barrett Esophagus / Q000453:epidemiology*; D004938:Esophageal Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012959:Socioeconomic Factors; D013030:Spain / Q000453:epidemiology; D055815:Young Adult