Plazomicin is effective in a non-human primate pneumonic plague model.
The efficacy of plazomicin for pneumonic plague was evaluated in a non-human primate model. African Green monkeys challenged with a lethal aerosol of Yersinia pestis [median (range) of 98 (15-331) LD50s] received placebo (n=12) or 'humanized' dose regimens (6.25, 12.5 or 25mg/kg every 24h) of plazomicin (n=52) after the onset of fever for a duration of 5 or 10days. All animals treated with placebo died, while 36 plazomicin-treated animals survived through study end. The majority (33/36) were either in the 10-day (high-/mid-/low-dose) or 5-day high-dose groups. The findings suggest an exposure range of plazomicin for treatment of pneumonic/bacteremic Y. pestis infection in humans.
Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. SE, Albuquerque, NM 87108, United States.
William M
WM
Mega
Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. SE, Albuquerque, NM 87108, United States.
Melanie
M
Doyle-Eisele
Former or Current Employees of Achaogen Inc., 7000 Shoreline Ct., South San Francisco, CA 94080, United States.
Robert T
RT
Cass
Former or Current Employees of Achaogen Inc., 7000 Shoreline Ct., South San Francisco, CA 94080, United States.
Corwin F
CF
Kostrub
Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. SE, Albuquerque, NM 87108, United States.
Robert L
RL
Sherwood
Former or Current Employees of Achaogen Inc., 7000 Shoreline Ct., South San Francisco, CA 94080, United States.
Matthew A
MA
Metz
Former or Current Employees of Achaogen Inc., 7000 Shoreline Ct., South San Francisco, CA 94080, United States. Electronic address: rcirz@achaogen.com.
Ryan T
RT
Cirz
D000818:Animals; D002522:Chlorocebus aethiops; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D008968:Molecular Conformation; D010930:Plague / Q000188:drug therapy*; D012853:Sisomicin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use
C550938:plazomicin; D012853:Sisomicin
Aminoglycoside; Animal rule; Plague; Plazomicin; Pneumonia; Yersinia pestis