Treatment of brain metastasis: current status and future directions.
The purpose of this review is to highlight the most recent advances in the management of brain metastases.



Role of local therapies (surgery and stereotactic radiosurgery), new approaches to minimize cognitive sequelae following whole-brain radiotherapy and advances in targeted therapies have been reviewed.



The implications for clinical trials and daily practice of the increasing use of stereotactic radiosurgery in multiple brain metastases and upfront targeted agents in asymptomatic brain metastases are discussed.
Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy.
Roberta
R
Rudà
Federica
F
Franchino
Riccardo
R
Soffietti
D001932:Brain Neoplasms / Q000532:radiotherapy* / Q000556:secondary*; D017326:Clinical Trials, Phase III as Topic; D006801:Humans; D016634:Radiosurgery / Q000379:methods / Q000639:trends; D016032:Randomized Controlled Trials as Topic