The declining frequency of inducible myocardial ischemia during stress echocardiography over 27 consecutive years (1983-2009).
BACKGROUND
Previous studies have suggested a decline in positivity of stress cardiac imaging, suggesting the need for developing better strategies for test selection to achieve acceptable cost-effectiveness balance. The aim of this retrospective study was to assess the rate of positivity of stress echocardiography (SE) over 27 consecutive years.


METHODS
We assessed the rate of SE positivity in 2007 patients without previous myocardial infarction or coronary revascularization who performed SE in a tertiary care referral center from 1983 to 2009. SE was performed with dipyridamole (1427), dobutamine (136) or exercise (444).


RESULTS
There was a progressive decline over time in the rate of SE positivity from 42% (1983-1991) to 22% (2001-2009), with a relative increase of patients with low pre-test probability of disease (from 5% to 27%). The percentage of patients studied with SE under anti-ischemic therapy increased markedly (from 8% in the first to 61% in the last nine years).


CONCLUSIONS
Over 27 consecutive years, we observed a steady decline in SE positivity rate (with >5-fold increase of low probability patients), with almost 8-fold increase in anti-ischemic therapy at testing. We probably need refined criteria of referral for testing and/or better ways to titrate the negative response beyond wall motion abnormalities during SE.
CNR Institute of Clinical Physiology, Pisa, Italy. Electronic address: clara@ifc.cnr.it.
Clara
C
Carpeggiani
CNR Institute of Clinical Physiology, Pisa, Italy.
Patrizia
P
Landi
CNR Institute of Clinical Physiology, Pisa, Italy.
Claudio
C
Michelassi
CNR Institute of Clinical Physiology, Pisa, Italy.
Rosa
R
Sicari
CNR Institute of Clinical Physiology, Pisa, Italy.
Eugenio
E
Picano
D000368:Aged; D025401:Echocardiography, Stress / Q000379:methods / Q000639:trends*; D004562:Electrocardiography / Q000379:methods / Q000639:trends*; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000503:physiopathology*; D011446:Prospective Studies; D012189:Retrospective Studies
Appropriateness; Echocardiography; Ischemia; Stress