Receptor for Advanced Glycation End Products (RAGE) in Type 1 Diabetes Pathogenesis.
The receptor for advanced glycation end products (RAGE) is a novel protein increasingly studied in the pathogenesis of type 1 diabetes (T1D). RAGE is expressed by several immune cell types, including T cells, antigen-presenting cells, endothelial cells, and the endocrine cells of the pancreatic islets. RAGE binds various ligands including advanced glycation end products (AGEs), high-mobility group box protein 1 (HMGB1), S100 proteins, β-amyloid, β-sheet fibrils, and lipopolysaccharide. AGEs are a particularly interesting ligand because their exogenous introduction into the body can be accelerated by the consumption of AGE-rich processed foods. This review will detail RAGE isoforms and its ligands and discuss how RAGE binding on the aforementioned cells could be linked to T1D pathogenesis.
Glycation and Diabetes, Mater Research Institute, Translational Research Institute, The University of Queensland, 37 Kent St, Woolloongabba, Brisbane, Queensland, Australia.|School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland, Australia.
Sherman S
SS
Leung
Glycation and Diabetes, Mater Research Institute, Translational Research Institute, The University of Queensland, 37 Kent St, Woolloongabba, Brisbane, Queensland, Australia. Josephine.forbes@mater.uq.edu.au.|Mater Clinical School, School of Medicine, The University of Queensland, Brisbane, Queensland, Australia. Josephine.forbes@mater.uq.edu.au.
Josephine M
JM
Forbes
Glycation and Diabetes, Mater Research Institute, Translational Research Institute, The University of Queensland, 37 Kent St, Woolloongabba, Brisbane, Queensland, Australia.
Danielle J
DJ
Borg
D056704:Adaptive Immunity; D000818:Animals; D040501:Calgranulin A / Q000502:physiology; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology*; D017127:Glycation End Products, Advanced / Q000378:metabolism; D024243:HMGB1 Protein / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate; D007515:Islets of Langerhans / Q000502:physiology; D000067759:Receptor for Advanced Glycation End Products / Q000502:physiology*
D040501:Calgranulin A; D017127:Glycation End Products, Advanced; D024243:HMGB1 Protein; D000067759:Receptor for Advanced Glycation End Products
Advanced glycation end products; High-mobility group box protein 1; Immunology; Receptor for advanced glycation end products; S100 calgranulins; Type 1 diabetes pathogenesis