Organotin(IV) Carboxylates as Promising Potential Drug Candidates in the Field of Cancer Chemotherapy.
Medicinal inorganic chemistry plays an important role in exploring the properties of metal ions for the designing of new drugs. The field has been stimulated by the success of cis-platin, the world best selling anticancer drug and platinum complexes with reduced toxicity, oral activity and activity against resistant tumors are currently on clinical trial. The use of cis-platin is, however, severely limited by its toxic side-effects. This has stimulated chemists to employ different strategies in the development of new metal-based anticancer agents with different mechanisms of action. The discovery of new non-covalent interactions with the classical target, DNA, was the first developing step in the treatment of cancer. The use of organometallic compounds as a medicine is very common now a days because it offers potential advantages over the more common organic-based drugs. In this article we have highlighted the anticancer activity of the organotin(IV) carboxylates published in the last few years (from 2008 to 2016). In most cases they present lower IC50 values than those of cisplatin, which indicates their high activity against the cancer cell lines. The summarized data reveal that every year new organotin(IV) carboxylate complexes are synthesized with the aim of new anticancer agent with much better results than the than the corresponding activity of cis-platin or other clinically approved drugs. In addition to the advantages of high activity, compared to the platinum compound, tin complexes are much cheaper. Thus by using organotin carboxylate for clinical medicine, cost reduction, dosage reduction and effect enhancement will be reached.
Department of Chemistry, University of Science & Technology Bannu, 28100, Pakistan.
Muhammad
M
Sirajuddin
Saqib
S
Ali
D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use*; D002264:Carboxylic Acids / Q000737:chemistry*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D009947:Organotin Compounds / Q000737:chemistry / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D002264:Carboxylic Acids; D009947:Organotin Compounds
Cancer Chemotherapy; chemotherapeutic agents.; cis-platin; metal-;based compounds