Cranial Magnetic Resonance Imaging in Elderly American Indians: Design, Methods, and Implementation of the Cerebrovascular Disease and Its Consequences in American Indians Study.
The Cerebrovascular Disease and its Consequences in American Indians (CDCAI) Study recruited surviving members of a 20-year, longitudinal, population-based cohort of American Indians focused on cardiovascular disease, its risk factors, and its consequences. The goal of the CDCAI Study is to characterize the burden, risk factors, and manifestations of vascular brain injury identified on cranial MRI. The CDCAI Study investigators enrolled 1,033 participants aged 60 and older from 11 American Indian communities and tribes in the Northern Plains, Southern Plains, and Southwestern United States. In addition to cranial MRI performed according to standardized protocols, participants underwent extensive medical interview, clinical examination, neurocognitive testing, physical function evaluation, electrocardiogram, and provided blood and urine specimens. Participants also self-administered questionnaires covering demographics, quality of life, and medical history. This report describes the design, implementation, and some of the unique challenges of this study and data collection.
Partnerships for Native Health, Elson S. Floyd College of Medicine, Washington State University, Seattle, Wash., USA.
Astrid M
AM
Suchy-Dicey
Dean
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Shibata
Lyle G
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Best
Steven P
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Verney
William T
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Longstreth
Elisa T
ET
Lee
Peter M
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Okin
Richard
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Devereux
Marcia
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O'Leary
Tauqeer
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Ali
Paul N
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Jensen
Clemma
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Muller
Lonnie A
LA
Nelson
Everett
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Rhoades
Tara
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Madhyastha
Thomas J
TJ
Grabowski
Norman
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Beauchamp
Jason G
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Umans
Dedra
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Buchwald
D000368:Aged; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging* / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D006801:Humans; D007198:Indians, North American; D008279:Magnetic Resonance Imaging; D008297:Male; D012107:Research Design; D012307:Risk Factors; D011795:Surveys and Questionnaires