Weight Change Is a Characteristic Non-Motor Symptom in Drug-Naïve Parkinson's Disease Patients with Non-Tremor Dominant Subtype: A Nation-Wide Observational Study.
Despite the clinical impact of non-motor symptoms (NMS) in Parkinson's disease (PD), the characteristic NMS in relation to the motor subtypes of PD is not well elucidated. In this study, we enrolled drug-naïve PD patients and compared NMS between PD subtypes. We enrolled 136 drug-naïve, early PD patients and 50 normal controls. All the enrolled PD patients were divided into tremor dominant (TD) and non-tremor dominant (NTD) subtypes. The Non-Motor Symptom Scale and scales for each NMS were completed. We compared NMS and the relationship of NMS with quality of life between normal controls and PD patients, and between the PD subtypes. Comparing with normal controls, PD patients complained of more NMS, especially mood/cognitive symptoms, gastrointestinal symptoms, unexplained pain, weight change, and change in taste or smell. Between the PD subtypes, the NTD subtype showed higher total NMS scale score and sub-score about weight change. Weight change was the characteristic NMS related to NTD subtype even after controlled other variables with logistic regression analysis. Even from the early stage, PD patients suffer from various NMS regardless of dopaminergic medication. Among the various NMS, weight change is the characteristic NMS associated with NTD subtype in PD patients.
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.|Neuroscience Center, Samsung Medical Center, Seoul, Republic of Korea.
Jun Kyu
JK
Mun
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.|Neuroscience Center, Samsung Medical Center, Seoul, Republic of Korea.
Jinyoung
J
Youn
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.|Neuroscience Center, Samsung Medical Center, Seoul, Republic of Korea.
Jin Whan
JW
Cho
Department of Neurology, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Republic of Korea.
Eung-Seok
ES
Oh
Department of Neurology, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Republic of Korea.
Ji Sun
JS
Kim
Department of Biostatistics, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Republic of Korea.
Suyeon
S
Park
Department of Neurology, Gangneung Asan Hospital, College of Medicine, University of Ulsan, Gangneung, Republic of Korea.
Wooyoung
W
Jang
Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
Jin Se
JS
Park
Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Seong-Beom
SB
Koh
Department of Neurology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
Jae Hyeok
JH
Lee
Department of Neurology, College of Medicine, Inje University, Ilsan-Paik Hospital, Ilsan, Republic of Korea.
Hee Kyung
HK
Park
Department of Neurology, College of Medicine, Seoul National University, Seoul, Republic of Korea.
Han-Joon
HJ
Kim
Department of Neurology, College of Medicine, Seoul National University, Seoul, Republic of Korea.
Beom S
BS
Jeon
Department of Neurology, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
Hae-Won
HW
Shin
Department of Neurology, National Health, Insurance Corporation Ilsan Hospital, Ilsan, Republic of Korea.
Sun-Ah
SA
Choi
Department of Neurology, Inje University, Busan Paik Hospital, Busan, Republic of Korea.
Sang Jin
SJ
Kim
Department of Neurology, Chonnam National University Medical School, Gwangju, Republic of Korea.
Seong-Min
SM
Choi
Department of Neurology, Presbyterian Medical Center, Jeonju, Republic of Korea.
Ji-Yun
JY
Park
Department of Neurology, College of Medicine, Inje University Seoul Paik Hospital, Seoul, Republic of Korea.
Ji Young
JY
Kim
Department of Neurology, College of Medicine, University of Ulsan, Seoul, Republic of Korea.
Sun Ju
SJ
Chung
Department of Neurology, College of Medicine, University of Ulsan, Seoul, Republic of Korea.
Chong Sik
CS
Lee
Department of Neurology, Kyung Hee University College of Medicine, Seoul, Republic of Korea.
Tae-Beom
TB
Ahn
Department of Neurology, CHA University College of Medicine, Bundang, Republic of Korea.
Won Chan
WC
Kim
Department of Neurology, CHA University College of Medicine, Bundang, Republic of Korea.
Hyun Sook
HS
Kim
Department of Neurology, Dong-A University College of Medicine, Busan, Republic of Korea.
Sang Myung
SM
Cheon
Department of Neurology, Dong-A University College of Medicine, Busan, Republic of Korea.
Jae Woo
JW
Kim
Department of Neurology, College of Medicine, Hanyang University, Seoul, Republic of Korea.
Hee-Tae
HT
Kim
Department of Neurology, Seoul National University Boramae Hospital, Seoul, Republic of Korea.
Jee-Young
JY
Lee
Department of Neurology, College of Medicine, Chungbuk National University Hospital, Jeonju, Republic of Korea.
Ji Sun
JS
Kim
Department of Neurology, Pusan National University School of Medicine and Medical Research Institute, Busan, Republic of Korea.
Eun-Joo
EJ
Kim
Department of Neurology, Seoul National University Bundang Hospital, Bundang, Republic of Korea.
Jong-Min
JM
Kim
Department of Neurology, College of Medicine, the Catholic University of Korea, Seoul, Republic of Korea.
Kwang Soo
KS
Lee
Department of Neurology, College of Medicine, the Catholic University of Korea, Seoul, Republic of Korea.
Joong-Seok
JS
Kim
Department of Neurology, Kosin University College of Medicine, Busan, Republic of Korea.
Min-Jeong
MJ
Kim
Department of Neurology, College of Medicine, Inje University, Sanggye Paik Hospital, Seoul, Republic of Korea.
Jong Sam
JS
Baik
Department of Neurology, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
Ki-Jong
KJ
Park
Department of Neurology, Konkuk University School of Medicine, Seoul, Republic of Korea.
Hee Jin
HJ
Kim
Department of Neurology, Yeungnam University College of Medicine, Daegu, Republic of Korea.
Mee Young
MY
Park
Department of Neurology, Jeju National University Hospital, Jeju, Republic of Korea.
Ji Hoon
JH
Kang
Department of Neurology, Jeju National University Hospital, Jeju, Republic of Korea.
Sook Kun
SK
Song
Department of Neurology, Konyang University Hospital, Daejeon, Republic of Korea.
Yong Duk
YD
Kim
Department of Neurology, Ewha Womans University Mokdong Hospital, Seoul, Republic of Korea.
Ji Young
JY
Yun
Department of Neurology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Ho-Won
HW
Lee
Department of Neurology, College of Medicine, the Catholic University of Korea, Incheon, Republic of Korea.
In-Uk
IU
Song
Department of Neurology, Yonsei University, College of Medicine, Seoul, Republic of Korea.
Young H
YH
Sohn
Department of Neurology, Yonsei University, College of Medicine, Seoul, Republic of Korea.
Phil Hyu
PH
Lee
Department of Neurology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Republic of Korea.
Jeong-Ho
JH
Park
Department of Neurology, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Republic of Korea.
Hyung Geun
HG
Oh
Department of Neurology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Kun Woo
KW
Park
Department of Neurology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Republic of Korea.
Do-Young
DY
Kwon
D000368:Aged; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000145:classification / Q000175:diagnosis / Q000473:pathology*; D056910:Republic of Korea; D012720:Severity of Illness Index; D015431:Weight Loss