Catalytic Enantioselective Total Synthesis of Hypocrolide A.
The first and catalytic enantioselective total synthesis of hypocrolide A (>99% ee) in 12 steps, as well as other botryanes, is described. The absolute configurations of these compounds have been unambiguously confirmed or reassigned accordingly. The key reactions in this study include an unusual rhodium-catalyzed intramolecular [4 + 2] cycloaddition and a biomimetic oxidative [3 + 2] cycloaddition based on our revised biogenetic pathway.
Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School , Shenzhen 518055, China.|Department of Chemistry, South University of Science and Technology of China , Shenzhen 518055, China.
Chuang
C
Qiao
Department of Chemistry, South University of Science and Technology of China , Shenzhen 518055, China.
Wen
W
Zhang
Department of Chemistry, South University of Science and Technology of China , Shenzhen 518055, China.
Jing-Chun
JC
Han
Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School , Shenzhen 518055, China.|Department of Chemistry, South University of Science and Technology of China , Shenzhen 518055, China.
Chuang-Chuang
CC
Li