Genetic Analysis of the ZNF512B, SLC41A1, and ALDH2 Polymorphisms in Parkinson's Disease in the Iranian Population.
OBJECTIVE
Parkinson's disease (PD) is one of the most common neurodegenerative disorders; its etiology includes both genetic and environmental factors and their interactions. The ZNF512B, SLC41A1, and ALDH2 genes have recently been identified as contributing to PD. In this study we investigated the association of alleles of these genes with PD in the Iranian population.


METHODS
In a case-control study, rs2275294, rs11240569, and rs4767944, three single nucleotide polymorphisms in ZNF512B, SLC41A1, and ALDH2 genes, respectively, were genotyped in 490 PD patients and 490 controls. The genotype and allele frequencies were compared between the two groups using chi-square and logistic regression tests.


RESULTS
A significant association between the rs11240569 polymorphism and a reduced risk of PD was found (p = 0.014, OR = 0.76, 95% CI: 0.60-0.94 for allele frequencies). We did not find any associations between PD and the rs2275294 and rs4767944 polymorphisms.


CONCLUSIONS
The association of rs11240569 polymorphism in SLC41A1 gene with reduced risk of PD was replicated in our population.
1 Neuroscience Research Center, Tabriz University of Medical Sciences , Tabriz, Iran .
Faranak
F
Madadi
2 Department of Medical Genetics, School of Medicine, Tabriz University of Medical Sciences , Tabriz, Iran .
Mahmoud Shekari
MS
Khaniani
3 Neurology Department, Ganjavian Hospital, Dezful University of Medical Sciences , Dezful, Iran .
Ehsan Esmaili
EE
Shandiz
4 Department of Neurology, School of Medicine, Tabriz University of Medical Sciences , Tabriz, Iran .
Hormoz
H
Ayromlou
4 Department of Neurology, School of Medicine, Tabriz University of Medical Sciences , Tabriz, Iran .
Safa
S
Najmi
5 Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences , Tehran, Iran .
Babak
B
Emamalizadeh
5 Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences , Tehran, Iran .
Shaghayegh
S
Taghavi
6 Noncommunicable Diseases Research Center, Fasa University of Medical Sciences , Fasa, Iran .
Javad
J
Jamshidi
7 Department of Neurology, School of Medicine, Imam Khomeini Hospital and Iranian Center of Neurological Research, Tehran University of Medical Sciences , Tehran, Iran .
Abbas
A
Tafakhori
8 Movement Disorders Clinic, Hazrat Rassol Hospital, Iran University of Medical Sciences , Tehran, Iran .
Gholam-Ali
GA
Shahidi
5 Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences , Tehran, Iran .
Hossein
H
Darvish
D000368:Aged; D000071396:Aldehyde Dehydrogenase, Mitochondrial / Q000235:genetics*; D001457:Anion Exchange Protein 1, Erythrocyte / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D005260:Female; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
D001457:Anion Exchange Protein 1, Erythrocyte; D002352:Carrier Proteins; C454201:SLC4A1 protein, human; C554937:ZNF512B protein, human; C096127:ALDH2 protein, human; D000071396:Aldehyde Dehydrogenase, Mitochondrial