Colloids in Acute Burn Resuscitation.
Colloids have been used in varying capacities throughout the history of formula-based burn resuscitation. There is sound experimental evidence that demonstrates colloids' ability to improve intravascular colloid osmotic pressure, expand intravascular volume, reduce resuscitation requirements, and limit edema in unburned tissue following a major burn. Fresh frozen plasma appears to be a useful and effective immediate burn resuscitation fluid but its benefits must be weighed against its costs, and risks of viral transmission and acute lung injury. Albumin, in contrast, is less expensive and safer and has demonstrated ability to reduce resuscitation requirements and possibly limit edema-related morbidity.
Department of Surgery, Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, University of Toronto, Room D712, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada. Electronic address: robert.cartotto@sunnybrook.ca.
Robert
R
Cartotto
Department of Surgery, Shriners Hospitals for Children Northern California, University of California, Davis, 2425 Stockton Boulevard, Sacramento, CA 95817, USA.
David
D
Greenhalgh
D000418:Albumins / Q000627:therapeutic use*; D002056:Burns / Q000503:physiopathology / Q000628:therapy*; D003102:Colloids / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D003911:Dextrans / Q000627:therapeutic use; D005440:Fluid Therapy / Q000379:methods*; D005780:Gelatin / Q000627:therapeutic use; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000627:therapeutic use; D010949:Plasma; D012151:Resuscitation / Q000379:methods*
D000418:Albumins; D003102:Colloids; D003911:Dextrans; D006895:Hydroxyethyl Starch Derivatives; D005780:Gelatin
Burn; Colloids; Fluid; Resuscitation; Shock