Association of adiponectin receptor 1 gene - 106 C > T variant with susceptibility to colorectal cancer.
BACKGROUND
Colorectal cancer (CRC) is the fourth leading cause of cancer-related death around the world and accumulated evidence indicates the association between CRC and obesity and insulin resistance.


OBJECTIVE
Regarding the role of adiponectin in obesity and insulin resistance, we explored whether genetic variants in adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) are associated with CRC risk.


METHODS
ADIPOQ (rs2241766) and ADIPOR1 (rs2275738) gene variants were genotyped in 261 cases with CRC and 339 controls using PCR-RFLP method.


RESULTS
In this study, no significant difference was observed for ADIPOQ gene rs2241766 variant between the cases and controls. However, carriers of the ADIPOR1 (rs2275738) "CC + CT" genotype compared with "TT" genotype occurred more frequently in the cases with CRC than the controls, and the difference remained significant after adjustment for age, BMI, sex, smoking status, NSAID use, and family history of CRC (P = 0.048; OR = 1.49, 95%CI = 1.01-2.20). Interestingly, after adjustment for confounding factors the ADIPOR1 "CC + TC" genotype compared with "TT" genotype was also associated with an increased risk for obesity in the cases (P = 0.040; OR = 1.86, 95%CI = 1.03-3.36).


CONCLUSIONS
Our findings suggest for the first time that the - 106 C > T (rs2275738) variant of ADIPOR1 gene may be a genetic contributor to CRC and obesity risk in the cases with CRC. However, further studies with bigger sample size are needed to validate these findings.
Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Touraj
T
Mahmoudi
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Khatoon
K
Karimi
Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Negar
N
Karimi
Department of Physiology, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
Hamid
H
Farahani
Internal Medicine Department, Semnan University of Medical Sciences, Semnan, Iran.
Hossein
H
Nobakht
Internal Medicine Department, Semnan University of Medical Sciences, Semnan, Iran.
Reza
R
Dabiri
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Mohsen
M
Vahedi
Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad Reza
MR
Zali
ADIPOQ; ADIPOR1; Colorectal cancer; Gene polymorphism