The Potentials and Pitfalls of Microarrays in Neglected Tropical Diseases: A Focus on Human Filarial Infections.
Data obtained from expression microarrays enables deeper understanding of the molecular signatures of infectious diseases. It provides rapid and accurate information on how infections affect the clustering of gene expression profiles, pathways and networks that are transcriptionally active during various infection states compared to conventional diagnostic methods, which primarily focus on single genes or proteins. Thus, microarray technologies offer advantages in understanding host-parasite interactions associated with filarial infections. More importantly, the use of these technologies can aid diagnostics and helps translate current genomic research into effective treatment and interventions for filarial infections. Studying immune responses via microarray following infection can yield insight into genetic pathways and networks that can have a profound influence on the development of anti-parasitic vaccines.
Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Private Mail Bag, Kwame Nkrumah University Science & Technology, KNUST, Kumasi 233, Ghana. senkwarteng@yahoo.co.uk.|Department of Biochemistry and Biotechnology, Kwame Nkrumah University Science & Technology, KNUST, Kumasi 233, Ghana. senkwarteng@yahoo.co.uk.
Alexander
A
Kwarteng
Department of Biochemistry and Biotechnology, Kwame Nkrumah University Science & Technology, KNUST, Kumasi 233, Ghana. st.ahuno@outlook.com.
Samuel Terkper
ST
Ahuno
filarial; microarray; signaling pathways; transcriptomics; whole blood