[Shades of grays for implanting an enzymatic biofuel cell].
An implanted biofuel cell (IBFC) is a novel device that provides the means to create electricity from glucose and oxygen, using an original architecture for the IBFC that provides efficient work inside a living organism. In the future these IBFCs will be required to power implanted devices to assist failing physiological functions in humans. The active ingredients of such IBFCs are glucose oxidase at the anode and laccase at the cathode. These enzymes are entrapped in a 3D network of conductive and insulated materials. This publication solves the issue of the sterilization of such a complex device, using gamma irradiation. A 12kGy dose was sufficient to show absence of implant infection in all the implantations performed. We also prove in vitro functioning of both bioelectrodes with a high dose of 42kGy.
Université Grenoble Alpes/CNRS/Inserm/TIMC-IMAG UMR 5525, 38041 Grenoble, France.
Jean-Pierre
JP
Alcaraz
Université Grenoble Alpes/CNRS/Inserm/TIMC-IMAG UMR 5525, 38041 Grenoble, France.
Sarra El
SE
Ichi-Ribault
ARC-Nucléart CEA-Grenoble, 17, rue des Martyrs, F38054  Grenoble Cedex 9, France.
Laurent
L
Cortella
Stérilisation centrale, CHU de Grenoble, 38700 La Tronche, France.
Catherine
C
Guimier-Pingault
Université Grenoble Alpes/CNRS/Inserm/TIMC-IMAG UMR 5525, 38041 Grenoble, France.
Abdelkader
A
Zebda
Université Grenoble Alpes/CNRS/Inserm/TIMC-IMAG UMR 5525, 38041 Grenoble, France.
Philippe
P
Cinquin
Université Grenoble Alpes/CNRS/Inserm/TIMC-IMAG UMR 5525, 38041 Grenoble, France.
Donald K
DK
Martin
D000818:Animals; D001674:Bioelectric Energy Sources; D015374:Biosensing Techniques; D004567:Electrodes, Implanted; D004800:Enzymes, Immobilized / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D005949:Glucose Oxidase / Q000378:metabolism; D006801:Humans; D042845:Laccase / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*
D004800:Enzymes, Immobilized; D005949:Glucose Oxidase; D042845:Laccase; D005947:Glucose; D010100:Oxygen