Molecular Markers in Bone and Soft-Tissue Tumors.
Many sarcomas such as osteosarcoma have complex molecular compositions and behaviors that make standardized treatment difficult for patients with these tumors. Chromosomal translocations are noted in specific bone and soft-tissue sarcomas, and there are molecular tests (polymerase chain reaction [PCR] and fluorescence in situ hybridization [FISH]) used for accurate diagnosis. The translocations noted in sarcomas may allow future therapeutic targeting.
University of California, San Francisco, San Francisco, California.
Rosanna
R
Wustrack
Departments of Pathology (K.C.) and Orthopaedic Surgery (K.W.), University of Pennsylvania, Philadelphia, Pennsylvania.
Kumarasen
K
Cooper
Departments of Pathology (K.C.) and Orthopaedic Surgery (K.W.), University of Pennsylvania, Philadelphia, Pennsylvania.
Kristy
K
Weber
D014408:Biomarkers, Tumor / Q000032:analysis*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D016133:Polymerase Chain Reaction; D012509:Sarcoma; D012983:Soft Tissue Neoplasms / Q000175:diagnosis*; D014178:Translocation, Genetic
D014408:Biomarkers, Tumor