Eight new eudesmane- and eremophilane-type sesquiterpenoids from Atractylodes lancea.
Phytochemical and pharmacological study on the rhizomes of Atractylodes lancea led to the identification of twenty-one compounds: six new eudesmane-type sesquiterpenoids (1-6), two new eremophilane-type sesquiterpenoids (7, 8), and thirteen known compounds (9-21). These new compounds were elucidated using extensive spectroscopic analyses with experimental and calculated electronic circular dichroism (ECD) for the configurational assignments. Notably, this study was the first report on the isolation of two eremophilane-type sesquiterpenoids (7, 8) from the genus Atractylodes. Compounds 5, 7, and 16 showed potent hepatoprotective activities against N-acetyl-p-aminophenol (APAP)-induced HepG2 cell injury at a concentration of 10μM (bicyclol as the positive drug).
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, People's Republic of China.
Kuo
K
Xu
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, People's Republic of China.
Zi-Ming
ZM
Feng
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, People's Republic of China.
Ya-Nan
YN
Yang
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, People's Republic of China.
Jian-Shuang
JS
Jiang
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, People's Republic of China.
Pei-Cheng
PC
Zhang
D000082:Acetaminophen / Q000009:adverse effects; D031174:Atractylodes / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure; D000081223:Polycyclic Sesquiterpenes; D027343:Rhizome / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry* / Q000302:isolation & purification
D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane; C018286:eremophilane compounds; D000082:Acetaminophen; C015872:eudesmane
Atractylodes lancea; Eremophilane; Eudesmane; Hepatoprotective activity; Sesquiterpenoids