Respiratory rate variability in sleeping adults without obstructive sleep apnea.
Characterizing respiratory rate variability (RRV) in humans during sleep is challenging, since it requires the analysis of respiratory signals over a period of several hours. These signals are easily distorted by movement and volitional inputs. We applied the method of spectral analysis to the nasal pressure transducer signal in 38 adults with no obstructive sleep apnea, defined by an apnea-hypopnea index <5, who underwent all-night polysomnography (PSG). Our aim was to detect and quantitate RRV during the various sleep stages, including wakefulness. The nasal pressure transducer signal was acquired at 100 Hz and consecutive frequency spectra were generated for the length of the PSG with the Fast Fourier Transform. For each spectrum, we computed the amplitude ratio of the first harmonic peak to the zero frequency peak (H1/DC), and defined as RRV as (100 - H1/DC) %. RRV was greater during wakefulness compared to any sleep stage, including rapid-eye-movement. Furthermore, RRV correlated with the depth of sleep, being lowest during N3. Patients spent most their sleep time supine, but we found no correlation between RRV and body position. There was a correlation between respiratory rate and sleep stage, being greater in wakefulness than in any sleep stage. We conclude that RRV varies according to sleep stage. Moreover, spectral analysis of nasal pressure signal appears to provide a valid measure of RRV during sleep. It remains to be seen if the method can differentiate normal from pathological sleep patterns.
Pulmonary, Critical Care and Sleep Medicine Division, The George Washington University MFA, Washington, District of Columbia ggutierrez@mfa.gwu.edu.
Guillermo
G
Gutierrez
Pulmonary, Critical Care and Sleep Medicine Division, The George Washington University MFA, Washington, District of Columbia.
Jeffrey
J
Williams
Pulmonary, Critical Care and Sleep Medicine Division, The George Washington University MFA, Washington, District of Columbia.
Ghadah A
GA
Alrehaili
Pulmonary, Critical Care and Sleep Medicine Division, The George Washington University MFA, Washington, District of Columbia.
Anna
A
McLean
Pulmonary, Critical Care and Sleep Medicine Division, The George Washington University MFA, Washington, District of Columbia.
Ramin
R
Pirouz
Department of Surgery, The George Washington University MFA, Washington, District of Columbia.
Richard
R
Amdur
Pulmonary, Critical Care and Sleep Medicine Division, The George Washington University MFA, Washington, District of Columbia.
Vivek
V
Jain
Pulmonary, Critical Care and Sleep Medicine Division, The George Washington University MFA, Washington, District of Columbia.
Jalil
J
Ahari
Pulmonary, Critical Care and Sleep Medicine Division, The George Washington University MFA, Washington, District of Columbia.
Amandeep
A
Bawa
Pulmonary, Critical Care and Sleep Medicine Division, The George Washington University MFA, Washington, District of Columbia.
Shawn
S
Kimbro
D000328:Adult; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology; D009666:Nose / Q000502:physiology; D017286:Polysomnography / Q000379:methods; D011187:Posture / Q000502:physiology; D011312:Pressure / Q000009:adverse effects; D056152:Respiratory Rate / Q000502:physiology*; D012189:Retrospective Studies; D012890:Sleep / Q000502:physiology*; D020181:Sleep Apnea, Obstructive; D012894:Sleep Stages / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology; D014836:Volition / Q000502:physiology; D014851:Wakefulness / Q000502:physiology
Monitoring; obstructive sleep apnea; respiratory rate variability; spectral analysis