Prognostic factors after hepatic resection for the single hepatocellular carcinoma larger than 5 cm.
OBJECTIVE
This study aimed to determine which factors affect the prognosis of hepatectomy for hepatocellular carcinoma (HCC) larger than 5 cm, including the prognostic difference between tumor sizes from 5-10 cm and larger than 10 cm.


METHODS
The medical records of 114 patients who underwent hepatectomy for single HCC larger than 5 cm were reviewed and analyzed retrospectively.


RESULTS
In the analysis of the entire cohort of 114 patients, the 5-year overall and diseases-free survival rates were 50% and 29%, respectively. In a comparison of survival rates between groups, tumor sizes of 5 to 10 cm and larger than 10 cm, the overall and disease-free survival rates were not significantly different, respectively (54% vs. 41%, P = 0.433 and 33% vs. 23%, P = 0.083). On multivariate analysis, positive hepatitis B, high prothrombin induced by vitamin K absence or antagonist-II levels over 200 mIU/mL, and vascular invasion (micro- and macrovascular invasion) were independent prognostic factors for recurrence after hepatic resection. However, tumor size larger than 10 cm was not significant for recurrence after resection.


CONCLUSIONS
This study shows that surgical resection of solitary HCC larger than 5 cm showed favorable overall survival. And there is no survival difference with tumors between 5-10 cm and larger than 10 cm.
Department of Surgery, Dongsan Medical Center, Keimyung Univsersity School of Medicine, Daegu, Korea.
Ji Hyun
JH
Noh
Department of Surgery, Dongsan Medical Center, Keimyung Univsersity School of Medicine, Daegu, Korea.
Tae-Seok
TS
Kim
Department of Surgery, Dongsan Medical Center, Keimyung Univsersity School of Medicine, Daegu, Korea.
Keun Soo
KS
Ahn
Department of Surgery, Dongsan Medical Center, Keimyung Univsersity School of Medicine, Daegu, Korea.
Yong Hoon
YH
Kim
Department of Surgery, Dongsan Medical Center, Keimyung Univsersity School of Medicine, Daegu, Korea.
Koo Jeong
KJ
Kang
Hepatectomy; Hepatocellular carcinoma; Prognosis