PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS.
The rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some of these mutations are associated with breast cancer risk as high as those associated with rare BRCA2 mutations. We aimed to estimate the relative risks associated with specific rare variants in PALB2, CHEK2 and ATM via a multicentre case-control study.



We genotyped 10 rare mutations using the custom iCOGS array: PALB2 c.1592delT, c.2816T>G and c.3113G>A, CHEK2 c.349A>G, c.538C>T, c.715G>A, c.1036C>T, c.1312G>T, and c.1343T>G and ATM c.7271T>G. We assessed associations with breast cancer risk (42 671 cases and 42 164 controls), as well as prostate (22 301 cases and 22 320 controls) and ovarian (14 542 cases and 23 491 controls) cancer risk, for each variant.



For European women, strong evidence of association with breast cancer risk was observed for PALB2 c.1592delT OR 3.44 (95% CI 1.39 to 8.52, p=7.1×10-5), PALB2 c.3113G>A OR 4.21 (95% CI 1.84 to 9.60, p=6.9×10-8) and ATM c.7271T>G OR 11.0 (95% CI 1.42 to 85.7, p=0.0012). We also found evidence of association with breast cancer risk for three variants in CHEK2, c.349A>G OR 2.26 (95% CI 1.29 to 3.95), c.1036C>T OR 5.06 (95% CI 1.09 to 23.5) and c.538C>T OR 1.33 (95% CI 1.05 to 1.67) (p≤0.017). Evidence for prostate cancer risk was observed for CHEK2 c.1343T>G OR 3.03 (95% CI 1.53 to 6.03, p=0.0006) for African men and CHEK2 c.1312G>T OR 2.21 (95% CI 1.06 to 4.63, p=0.030) for European men. No evidence of association with ovarian cancer was found for any of these variants.



This report adds to accumulating evidence that at least some variants in these genes are associated with an increased risk of breast cancer that is clinically important.
Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, Australia.
Melissa C
MC
Southey
Huntsman Cancer Institute, Salt Lake City, UT, USA.
David E
DE
Goldgar
Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit and Biocenter Oulu, University of Oulu, Nordlab Oulu, Oulu, Finland.
Robert
R
Winqvist
Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit and Biocenter Oulu, University of Oulu, Nordlab Oulu, Oulu, Finland.
Katri
K
Pylkäs
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Fergus
F
Couch
Department of Medical Genetics and National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, and the Department of Clinical Genetics, East Anglian Regional Genetics Service, Addenbrooke's Hospital.
Marc
M
Tischkowitz
Program in Cancer Genetics, Department of Human Genetics and Oncology, Lady Davis Institute, and Research Institute, McGill University Health Centre, McGill University, Montreal, Canada.
William D
WD
Foulkes
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge, UK.
Joe
J
Dennis
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge, UK.
Kyriaki
K
Michailidou
Department of Genetics, University of Pretoria, South Africa.
Elizabeth J
EJ
van Rensburg
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Tuomas
T
Heikkinen
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Heli
H
Nevanlinna
Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
John L
JL
Hopper
Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Thilo
T
Dörk
Center for Medical Genetics, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium.
Kathleen Bm
KB
Claes
Department of Pathology and Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Jorge
J
Reis-Filho
Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, Australia.
Zhi Ling
ZL
Teo
Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
Paolo
P
Radice
IFOM, the FIRC Institute of Molecular Oncology, Milan, Italy.
Irene
I
Catucci
IFOM, the FIRC Institute of Molecular Oncology, Milan, Italy.
Paolo
P
Peterlongo
Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, Australia.
Helen
H
Tsimiklis
Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, Australia.
Fabrice A
FA
Odefrey
Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
James G
JG
Dowty
Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands.
Marjanka K
MK
Schmidt
Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands.
Annegien
A
Broeks
Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands.
Frans B
FB
Hogervorst
Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands.
Senno
S
Verhoef
Australian Breast Cancer Tissue Bank, University of Sydney at the Westmead Institute for Medical Research, NSW, Australia.
Jane
J
Carpenter
Centre for Cancer Research, University of Sydney at the Westmead Institute for Medical Research, NSW, Australia.
Christine
C
Clarke
Division of Molecular Medicine, Pathology North, Newcastle and University of Newcastle, NSW, Australia.
Rodney J
RJ
Scott
University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.|David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, CA, USA.
Peter A
PA
Fasching
University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.|Unit of Biostatistics, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Lothar
L
Haeberle
Institute of Human Genetics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Arif B
AB
Ekici
University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
Matthias W
MW
Beckmann
Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK.
Julian
J
Peto
Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK.
Isabel
I
Dos-Santos-Silva
Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.
Olivia
O
Fletcher
Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.
Nichola
N
Johnson
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge, UK.
Manjeet K
MK
Bolla
Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy's & St. Thomas' NHS Foundation Trust in partnership with King's College London, London, UK.
Elinor J
EJ
Sawyer
Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, UK and Oxford NIHR Biomedical Research Centre, Headington, OX3 7LE.
Ian
I
Tomlinson
Surgery, Lambe Institute for Translational Science, NUIGalway, University Hospital Galway, Galway, Ireland.
Michael J
MJ
Kerin
Surgery, Lambe Institute for Translational Science, NUIGalway, University Hospital Galway, Galway, Ireland.
Nicola
N
Miller
Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.|National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany.
Federik
F
Marme
Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.|Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Barbara
B
Burwinkel
Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.|Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Rongxi
R
Yang
Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France.|University Paris-Sud, UMRS 1018, Villejuif, France.
Pascal
P
Guénel
Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France.|University Paris-Sud, UMRS 1018, Villejuif, France.
Thérèse
T
Truong
Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France.|University Paris-Sud, UMRS 1018, Villejuif, France.
Florence
F
Menegaux
Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France.|University Paris-Sud, UMRS 1018, Villejuif, France.
Marie
M
Sanchez
Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.|Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.
Stig
S
Bojesen
Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.|Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.
Sune F
SF
Nielsen
Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Henrik
H
Flyger
Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.|Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia, Spain.
Javier
J
Benitez
Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain.
M Pilar
MP
Zamora
Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain.
Jose Ignacio Arias
JI
Perez
Servicio de Anatomía Patológica, Hospital Monte Naranco, Oviedo, Spain.
Primitiva
P
Menéndez
Department of Epidemiology, University of California Irvine, Irvine, California, USA.
Hoda
H
Anton-Culver
Beckman Research Institute of City of Hope, Duarte, California, USA.
Susan
S
Neuhausen
Department of Epidemiology, University of California Irvine, Irvine, California, USA.
Argyrios
A
Ziogas
Cancer Prevention Institute of California, Fremont, California, USA.
Christina A
CA
Clarke
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.|Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.|German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Hermann
H
Brenner
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Volker
V
Arndt
Saarland Cancer Registry, Saarbrücken, Germany.
Christa
C
Stegmaier
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.|Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart.|University of Tübingen, Tübingen, Germany.
Hiltrud
H
Brauch
Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University, Bochum (IPA), Germany.
Thomas
T
Brüning
Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany.
Yon-Dschun
YD
Ko
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Taru A
TA
Muranen
Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland.
Kristiina
K
Aittomäki
Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland.
Carl
C
Blomqvist
Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.|Department of Radiation Oncology, Hannover Medical School, Hannover, Germany.
Natalia V
NV
Bogdanova
N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus.
Natalia N
NN
Antonenkova
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Annika
A
Lindblom
Department of Oncology - Pathology, Karolinska Institutet, Stockholm, Sweden.
Sara
S
Margolin
School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, and Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland.|Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland.
Arto
A
Mannermaa
School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland, Kuopio, Finland.|Biocenter Kuopio, Cancer Center of Eastern Finland, Kuopio University Hospital, Kuopio, Finland.
Vesa
V
Kataja
School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, and Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland.|Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland.
Veli-Matti
VM
Kosma
School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, and Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland.|Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland.
Jaana M
JM
Hartikainen
QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Amanda B
AB
Spurdle
Research Department, Peter MacCallum Cancer Centre and The Sir Peter MacCallum Department of Oncology, University of Melbourne, Victoria, Australia.
kConFab
K
Investigators
Vesalius Research Center (VRC), VIB, Leuven, Belgium.|Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium.
Els
E
Wauters
Vesalius Research Center (VRC), VIB, Leuven, Belgium.|Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium.
Dominiek
D
Smeets
University Hospital Gasthuisberg, Leuven, Belgium.
Benoit
B
Beuselinck
University Hospital Gasthuisberg, Leuven, Belgium.
Giuseppe
G
Floris
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jenny
J
Chang-Claude
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Anja
A
Rudolph
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Petra
P
Seibold
Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany.
Dieter
D
Flesch-Janys
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Janet E
JE
Olson
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Celine
C
Vachon
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Vernon S
VS
Pankratz
Anatomical Pathology, The Alfred Hospital, Melbourne, Australia.
Catriona
C
McLean
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Christopher A
CA
Haiman
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Brian E
BE
Henderson
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Fredrick
F
Schumacher
Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI, USA.
Loic
L
Le Marchand
Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway.|Faculty of Medicine (Faculty Division Ahus), University of Oslo (UiO), Norway.
Vessela
V
Kristensen
Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway.
Grethe Grenaker
GG
Alnæs
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Wei
W
Zheng
Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA.|Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
David J
DJ
Hunter
Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA.|Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Sara
S
Lindstrom
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.|Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Susan E
SE
Hankinson
Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA.|Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Peter
P
Kraft
Ontario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.|Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Irene
I
Andrulis
Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.|Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Julia A
JA
Knight
Ontario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.
Gord
G
Glendon
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.|Laboratory Medicine Program, University Health Network, Toronto, Ontario; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Anna Marie
AM
Mulligan
Department of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland.
Arja
A
Jukkola-Vuorinen
Department of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland.
Mervi
M
Grip
Department of Pathology, Oulu University Hospital, University of Oulu, Oulu, Finland.
Saila
S
Kauppila
Department of Surgical Oncology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
Peter
P
Devilee
Department of Surgical Oncology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
Robert A E M
RA
Tollenaar
Family Cancer Clinic, Department of Medical Oncology, Erasmus MC-Daniel den Hoed Cancer Centre, Rotterdam, The Netherlands.|Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Caroline
C
Seynaeve
Family Cancer Clinic, Department of Medical Oncology, Erasmus MC-Daniel den Hoed Cancer Centre, Rotterdam, The Netherlands.|Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Antoinette
A
Hollestelle
The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.
Montserrat
M
Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Jonine
J
Figueroa
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Stephen J
SJ
Chanock
Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Warsaw, Poland.
Jolanta
J
Lissowska
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Kamila
K
Czene
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Hatef
H
Darabi
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Mikael
M
Eriksson
Faculty of Medicine, University of Southampton (UoS), Southampton UK.
Diana M
DM
Eccles
Faculty of Medicine, University of Southampton (UoS), Southampton UK.
Sajjad
S
Rafiq
Faculty of Medicine, University of Southampton (UoS), Southampton UK.
William J
WJ
Tapper
Faculty of Medicine, University of Southampton (UoS), Southampton UK.
Sue M
SM
Gerty
Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Maartje J
MJ
Hooning
Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
John W M
JW
Martens
Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands.
J Margriet
JM
Collée
Department of Surgical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands.
Madeleine
M
Tilanus-Linthorst
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Per
P
Hall
Human Genetics Division, Genome Institute of Singapore, Singapore 138672, Singapore.
Jingmei
J
Li
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Judith S
JS
Brand
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Keith
K
Humphreys
Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, UK.
Angela
A
Cox
Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, UK.
Malcolm W R
MW
Reed
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Craig
C
Luccarini
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Caroline
C
Baynes
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Alison M
AM
Dunning
Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ute
U
Hamann
Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.|Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota, Colombia.
Diana
D
Torres
Frauenklinik der Stadtklinik Baden-Baden, Baden-Baden, Germany.
Hans Ulrich
HU
Ulmer
Institute of Pathology, Städtisches Klinikum Karlsruhe, Karlsruhe, Germany.
Thomas
T
Rüdiger
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Anna
A
Jakubowska
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Jan
J
Lubinski
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.|Postgraduate School of Molecular Medicine, Warsaw Medical University, Warsaw, Poland.
Katarzyna
K
Jaworska
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Katarzyna
K
Durda
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Susan
S
Slager
Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Amanda E
AE
Toland
Roswell Park Cancer Institute, Buffalo, New York, USA.
Christine B
CB
Ambrosone
Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research "Demokritos", Aghia Paraskevi Attikis, Athens, Greece.
Drakoulis
D
Yannoukakos
Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK.|Division of Breast Cancer Research, Institute of Cancer Research, London, UK.
Anthony
A
Swerdlow
The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.
Alan
A
Ashworth
The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.
Nick
N
Orr
Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK.
Michael
M
Jones
Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Anna
A
González-Neira
Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Guillermo
G
Pita
Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
M Rosario
MR
Alonso
Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Nuria
N
Álvarez
Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Daniel
D
Herrero
Centre d'innovation Genome Quebec et University McGill Montreal Quebec, Canada.
Daniel C
DC
Tessier
McGill University, Montreal, Quebec, Canada.
Daniel
D
Vincent
McGill University, Montreal, Quebec, Canada.
Francois
F
Bacot
Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Quebec Research Center. Laval University, Quebec, Canada.
Jacques
J
Simard
Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Quebec Research Center. Laval University, Quebec, Canada.
Martine
M
Dumont
Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Quebec Research Center. Laval University, Quebec, Canada.
Penny
P
Soucy
The Institute of Cancer Research, London, SM2 5NG, UK.|Royal Marsden NHS Foundation Trust, Fulham, London, SW3 6JJ, UK.
Rosalind
R
Eeles
University of Warwick, Coventry, UK.
Kenneth
K
Muir
Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Fredrik
F
Wiklund
Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Henrik
H
Gronberg
Department of Medical Biochemistry and Genetics, University of Turku, and Tyks Microbiology and Genetics, Department of Medical Genetics, Turku University Hospital, Turku, Finland.|Institute of Biomedical Technology/BioMediTech, University of Tampere, Tampere, Finland.
Johanna
J
Schleutker
Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK-2730 Herlev, Denmark.
Børge G
BG
Nordestgaard
Department of Human Genetics University of Utah, Salt Lake City, UT, USA and Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.
Maren
M
Weischer
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Ruth C
RC
Travis
Surgical Oncology (Uro-Oncology: S4), University of Cambridge, Box 279, Addenbrooke's Hospital, Hills Road, Cambridge, UK and Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK.
David
D
Neal
Professor of Social Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS.
Jenny L
JL
Donovan
Nuffield Department of Surgical Sciences, Old Road Campus Research Building (off Roosevelt Drive), University of Oxford, Headington, Oxford, OX3 7DQ.
Freddie C
FC
Hamdy
Cambridge Institute of Public Health, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 0SR.
Kay-Tee
KT
Khaw
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.|Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA.
Janet L
JL
Stanford
International Epidemiology Institute, 1455 Research Blvd., Suite 550, Rockville, MD 20850.
William J
WJ
Blot
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Stephen
S
Thibodeau
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Daniel J
DJ
Schaid
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Joseph L
JL
Kelley
Department of Urology, University Hospital Ulm, Germany.|Institute of Human Genetics University Hospital Ulm, Germany.
Christiane
C
Maier
Brigham and Women's Hospital/Dana-Farber Cancer Institute, 45 Francis Street- ASB II-3, Boston, MA 02115.|Washington University, St Louis, Missouri.
Adam S
AS
Kibel
International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Cezary
C
Cybulski
Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine.
Lisa
L
Cannon-Albright
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Katja
K
Butterbach
Division of Cancer Prevention and Control, H. Lee Moffitt Cancer Center, 12902 Magnolia Dr., Tampa, Florida, USA.
Jong
J
Park
Molecular Medicine Center and Department of Medical Chemistry and Biochemistry, Medical University - Sofia, 2 Zdrave St, 1431, Sofia, Bulgaria.
Radka
R
Kaneva
Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and Schools of Life Science and Public Health, Queensland University of Technology, Brisbane, Australia.
Jyotsna
J
Batra
Department of Genetics, Portuguese Oncology Institute, Porto, Portugal and Biomedical Sciences Institute (ICBAS), Porto University, Porto, Portugal.
Manuel R
MR
Teixeira
The Institute of Cancer Research, London, SM2 5NG, UK.
Zsofia
Z
Kote-Jarai
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge, UK.
Ali Amin Al
AA
Olama
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge, UK.
Sara
S
Benlloch
University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Universitaetsstrasse 21-23, 91054 Erlangen, Germany.
Stefan P
SP
Renner
University Hospital Erlangen, Institute of Pathology, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Universitaetsstrasse 21-23, 91054 Erlangen, German.
Arndt
A
Hartmann
University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Universitaetsstrasse 21-23, 91054 Erlangen, Germany.
Alexander
A
Hein
University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Universitaetsstrasse 21-23, 91054 Erlangen, Germany.
Matthias
M
Ruebner
Vesalius Research Center, VIB, Leuven, Belgium.|Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Belgium.
Diether
D
Lambrechts
Department of Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Els
E
Van Nieuwenhuysen
Department of Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Ignace
I
Vergote
Department of Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Sandrina
S
Lambretchs
Department of Epidemiology, The Geisel School of Medicine at Dartmouth, Hannover, NH, USA.
Jennifer A
JA
Doherty
Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.|Department of Epidemiology, University of Washington, Seattle, WA, USA.
Mary Anne
MA
Rossing
German Cancer Research Center, Division of Cancer Epidemiology, Heidelberg, Germany.
Stefan
S
Nickels
German Cancer Research Center, Division of Cancer Epidemiology, Heidelberg, Germany.
Ursula
U
Eilber
Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany.
Shan
S
Wang-Gohrke
Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY.
Kunle
K
Odunsi
Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY.
Lara E
LE
Sucheston-Campbell
Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY.
Grace
G
Friel
Cancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, USA.
Galina
G
Lurie
Department of Pathology, Kapiolani Medical Center for Women and Children, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96826, USA.
Jeffrey L
JL
Killeen
Cancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, USA.
Lynne R
LR
Wilkens
Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.|Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Marc T
MT
Goodman
Department of Gynecology and Obstetrics, Friedrich Schiller University, Jena University Hospital, Jena, Germany.
Ingo
I
Runnebaum
Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany.
Peter A
PA
Hillemanns
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Liisa M
LM
Pelttari
Department of Pathology, Helsinki University Central Hospital, Helsinki, 00029 HUS, Finland.
Ralf
R
Butzow
University of Pittsburgh Department of Obstetrics, Gynecology and Reproductive Sciences and Ovarian Cancer Center of Excellence Pittsburgh PA USA.|University of Pittsburgh Department of Epidemiology, University of Pittsburgh Graduate School of Public Health and Womens Cancer Research Program, Magee-Womens Research Institute and University of Pittsburgh Cancer Institute Pittsburgh PA USA.
Francesmary
F
Modugno
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Robert P
RP
Edwards
The University of Texas School of Public Health, Houston, TX, USA.
Roberta B
RB
Ness
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY.
Kirsten B
KB
Moysich
Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte/ Evang. Huyssens-Stiftung/ Knappschaft GmbH, Essen, Germany.|Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany.
Andreas
A
du Bois
Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte/ Evang. Huyssens-Stiftung/ Knappschaft GmbH, Essen, Germany.|Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany.
Florian
F
Heitz
Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte/ Evang. Huyssens-Stiftung/ Knappschaft GmbH, Essen, Germany.|Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany.
Philipp
P
Harter
Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany.|Tuebingen University Hospital, Department of Women's Health, Tuebingen, Germany.
Stefan
S
Kommoss
Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Beth Y
BY
Karlan
Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Christine
C
Walsh
Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Jenny
J
Lester
Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
Allan
A
Jensen
Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.|Department of Obstetrics and Gynecology, Rigshospitalet, Copenhagen, Denmark.
Susanne Krüger
SK
Kjaer
Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.|Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
Estrid
E
Høgdall
Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
Bernard
B
Peissel
Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy.
Bernardo
B
Bonanni
Department of Experimental Oncology, Istituto Europeo di Oncologia (IEO), Milan, Italy and Cogentech Cancer Genetic Test Laboratory, Milan, Italy.
Loris
L
Bernard
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Ellen L
EL
Goode
University of Kansas Medical Center, Kansas City, KS, USA.
Brooke L
BL
Fridley
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Robert A
RA
Vierkant
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Julie M
JM
Cunningham
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Melissa C
MC
Larson
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Zachary C
ZC
Fogarty
Department of Medical Oncology, Mayo Clinic, Rochester, Minnesota, USA.
Kimberly R
KR
Kalli
College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas, USA.
Dong
D
Liang
Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Karen H
KH
Lu
Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Michelle A T
MA
Hildebrandt
Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Xifeng
X
Wu
Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Douglas A
DA
Levine
Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Fanny
F
Dao
Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Maria
M
Bisogna
Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, USA.
Andrew
A
Berchuck
Department of Statistical Science, Duke University, Durham, North Carolina, USA.
Edwin S
ES
Iversen
Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Jeffrey R
JR
Marks
Cancer Prevention, Detection & Control Research Program, Duke Cancer Institute, Durham, North Carolina, USA.
Lucy
L
Akushevich
Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Daniel W
DW
Cramer
Cancer Prevention, Detection & Control Research Program, Duke Cancer Institute, Durham, North Carolina, USA.
Joellen
J
Schildkraut
Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Kathryn L
KL
Terry
Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School.|Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, Massachusetts, USA.
Elizabeth M
EM
Poole
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.|Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School.
Meir
M
Stampfer
Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School.|Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, Massachusetts, USA.
Shelley S
SS
Tworoger
Cancer Prevention and Control Program, Rutgers Cancer Institute of New Jersey, The State University of New Jersey, New Brunswick, NJ, USA.
Elisa V
EV
Bandera
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Irene
I
Orlow
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Sara H
SH
Olson
Department of Gynecology and Obstetrics, Haukeland University Horpital, Bergen, Norway.|Centre for Cancer Biomarkers, Department of Clinical Sciences, University of Bergen, Bergen, Norway.
Line
L
Bjorge
Department of Gynecology and Obstetrics, Haukeland University Horpital, Bergen, Norway.|Centre for Cancer Biomarkers, Department of Clinical Sciences, University of Bergen, Bergen, Norway.
Helga B
HB
Salvesen
Radboud university medical center, Department of Gynaecology, Nijmegen, Netherlands.
Anne M
AM
van Altena
Radboud university medical centre, Radboud Institute for Health Sciences, Nijmegen, Netherlands.|Netherlands Comprehensive Cancer Organisation, Utrecht, Netherlands.|Department of Obstetrcs & Gynecology, Oregon Health & Science University.
Katja K H
KK
Aben
Radboud university medical centre, Radboud Institute for Health Sciences, Nijmegen, Netherlands.
Lambertus A
LA
Kiemeney
Radboud university medical center, Department of Gynaecology, Nijmegen, Netherlands.
Leon F A G
LF
Massuger
Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.
Tanja
T
Pejovic
Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.
Yukie
Y
Bean
Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada.|Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC Canada.
Angela
A
Brooks-Wilson
Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, SC, USA.|Hollings Cancer Center, Medical University of South Carolina, SC, USA.
Linda E
LE
Kelemen
Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, USA.
Linda S
LS
Cook
Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada.
Nhu D
ND
Le
International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Bohdan
B
Górski
International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Jacek
J
Gronwald
Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, Szczecin, Poland.
Janusz
J
Menkiszak
Department of Obstetrics and Gynecology, Rigshospitalet, Copenhagen, Denmark.
Claus K
CK
Høgdall
Gyn Clinic, Rigshospitalet, University of Copenhagen, Denmark.
Lene
L
Lundvall
Department of Pathology, Rigshospitalet, University of Copenhagen, Denmark.
Lotte
L
Nedergaard
Department of Oncology, Rigshospitalet, University of Copenhagen, Denmark.
Svend Aage
SA
Engelholm
Department of Oncology, University of Cambridge, Strangeways Research laboratory, Cambridge, UK.
Ed
E
Dicks
Department of Oncology, University of Cambridge, Strangeways Research laboratory, Cambridge, UK.
Jonathan
J
Tyrer
Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne.
Ian
I
Campbell
Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, Glasgow, UK.
Iain
I
McNeish
The Cancer Research UK Clinical Trials Unit, Beatson West of Scotland Cancer Centre, 1053 Great Western Road, Glasgow, G12 0YN.
James
J
Paul
Department of Gynaecological Oncology, Glasgow Royal Infirmary.
Nadeem
N
Siddiqui
Department of Gynaecological Oncology, Glasgow Royal Infirmary.
Rosalind
R
Glasspool
Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford CA, USA.
Alice S
AS
Whittemore
Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford CA, USA.
Joseph H
JH
Rothstein
Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford CA, USA.
Valerie
V
McGuire
Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford CA, USA.
Weiva
W
Sieh
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Hui
H
Cai
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Xiao-Ou
XO
Shu
Epidemiology Center, College of Medicine, University of South Florida, Tampa, Florida, USA.
Rachel T
RT
Teten
Epidemiology Center, College of Medicine, University of South Florida, Tampa, Florida, USA.
Rebecca
R
Sutphen
Public Health Ontario, Toronto, Canada.
John R
JR
McLaughlin
Women's College Research Institute, University of Toronto, Toronto, Ontario, Canada.
Steven A
SA
Narod
Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
Catherine M
CM
Phelan
Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
Alvaro N
AN
Monteiro
Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL, USA.
David
D
Fenstermacher
Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL, USA.
Hui-Yi
HY
Lin
Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
Jennifer B
JB
Permuth
Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
Thomas A
TA
Sellers
Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL, USA.
Y Ann
YA
Chen
Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
Ya-Yu
YY
Tsai
Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL, USA.
Zhihua
Z
Chen
Women's Cancer, Institute for Women's Health, UCL, London, United Kingdom.
Aleksandra
A
Gentry-Maharaj
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Simon A
SA
Gayther
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Susan J
SJ
Ramus
Women's Cancer, Institute for Women's Health, UCL, London, United Kingdom.
Usha
U
Menon
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Anna H
AH
Wu
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Celeste L
CL
Pearce
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
David
D
Van Den Berg
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.|Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Malcolm C
MC
Pike
Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Agnieszka
A
Dansonka-Mieszkowska
Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Joanna
J
Plisiecka-Halasa
Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Joanna
J
Moes-Sosnowska
Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Jolanta
J
Kupryjanczyk
Department of Oncology, University of Cambridge, Strangeways Research laboratory, Cambridge, UK.
Paul Dp
PD
Pharoah
Department of Oncology, University of Cambridge, Strangeways Research laboratory, Cambridge, UK.
Honglin
H
Song
Department of Medicine, The University of Melbourne Health, Australia.|The Royal Melbourne Hospital, Victoria 3050, Australia.
Ingrid
I
Winship
QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Georgia
G
Chenevix-Trench
Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia.|Cancer Epidemiology Centre, Cancer Council Victoria, Victoria, Australia.
Graham G
GG
Giles
Huntsman Cancer Institute, Salt Lake City, UT, USA.
Sean V
SV
Tavtigian
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge, UK.
Doug F
DF
Easton
Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia.|Cancer Epidemiology Centre, Cancer Council Victoria, Victoria, Australia.
Roger L
RL
Milne
D064007:Ataxia Telangiectasia Mutated Proteins / Q000235:genetics*; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism*; D016022:Case-Control Studies; D064447:Checkpoint Kinase 2 / Q000235:genetics*; D000076164:Fanconi Anemia Complementation Group N Protein; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D009154:Mutation; D009687:Nuclear Proteins / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism*; D012306:Risk; D025521:Tumor Suppressor Proteins / Q000235:genetics*
D000076164:Fanconi Anemia Complementation Group N Protein; D009687:Nuclear Proteins; C512790:PALB2 protein, human; D025521:Tumor Suppressor Proteins; D064447:Checkpoint Kinase 2; C576324:ATM protein, human; D064007:Ataxia Telangiectasia Mutated Proteins; C578634:CHEK2 protein, human
Cancer: breast; Cancer: ovary; Cancer: prostate; Genetics; cancer predisposition