α-Helical coiled-coil peptide materials for biomedical applications.
Self-assembling coiled coils, which occur commonly in native proteins, have received significant interest for the design of new biomaterials-based medical therapies. Considerable effort over recent years has led to a detailed understanding of the self-assembly process of coiled coils, and a diverse collection of strategies have been developed for designing functional materials using this motif. The ability to engineer the interface between coiled coils allows one to achieve variously connected components, leading to precisely defined structures such as nanofibers, nanotubes, nanoparticles, networks, gels, and combinations of these. Currently these materials are being developed for a range of biotechnological and medical applications, including drug delivery systems for controlled release, targeted nanomaterials, 'drug-free' therapeutics, vaccine delivery systems, and others. WIREs Nanomed Nanobiotechnol 2017, 9:e1424. doi: 10.1002/wnan.1424 For further resources related to this article, please visit the WIREs website.
Department of Biomedical Engineering, Duke University, Durham, NC, USA.
Yaoying
Y
Wu
Department of Biomedical Engineering, Duke University, Durham, NC, USA.
Joel H
JH
Collier
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D006801:Humans; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D010455:Peptides / Q000737:chemistry*; D000072756:Protein Conformation, alpha-Helical; D000068936:Theranostic Nanomedicine
D001672:Biocompatible Materials; D010455:Peptides