Sleep-disordered breathing and disorders of glucose metabolism.
OBJECTIVE
The authors identified the risk of disorders of glucose metabolism (DGM) for sleep-disordered breathing (SDB).


METHODS
We conducted a cross-sectional study in 536 men aged 33-84 years. Patients with diabetes medication were excluded for the analysis and DGM were diagnosed by fasting plasma glucose≥100mg/dl and/or 2h plasma glucose ≥140mg/dl.


RESULTS
The prevalence of DGM in subjects with and without severe SDB, which was judged by an apnea-hypopnea index (AHI) of 30, were 64.9% and 53.3%, which showed no significant difference. The adjusted odds ratios (ORs) (95% confidence intervals [CIs]) of the logarithmic-transformed AHI and that of C-reactive protein for DGM were 1.3 (0.87-2.0) and 2.3 (1.5-3.6), respectively. When the subjects were categorized by the severity of SDB, the ORs (95% CIs) of subjects with mild, moderate and severe SDB against subjects without SDB were 2.9 (1.8-4.6), 1.2 (0.72-2.1) and 1.5 (0.8-3.0), respectively.


CONCLUSIONS
A significant association was observed between mild SDB and the presence of DGM in male subjects of this study.
Department of Hygiene and Public Health, Nippon Medical School, Japan. Electronic address: kawada@nms.ac.jp.
Tomoyuki
T
Kawada
Department of Hygiene and Public Health, Nippon Medical School, Japan.
Masao
M
Katsumata
Department of Hygiene and Public Health, Nippon Medical School, Japan.
Hirofumi
H
Inagaki
Division of Health Evaluation & Promotion, Ota Memorial Hospital, Japan.
Takayuki
T
Nakamura
Division of Health Evaluation & Promotion, Ota Memorial Hospital, Japan.
Yoichi
Y
Kon
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism*; D003430:Cross-Sectional Studies; D044882:Glucose Metabolism Disorders / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012891:Sleep Apnea Syndromes / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*
D001786:Blood Glucose
Apnea-hypopnea index; Glucose metabolism; Risk assessment; Sleep disordered breathing