In one harness: the interplay of cellular responses and subsequent cell fate after quantum dot uptake.
Rapid growth and expansion of engineered nanomaterials will occur when the technology can be used safely. Quantum dots have excellent prospects in clinical applications, but the issue of toxicity has not yet been resolved. To enable their medical implementation, the effect on, and mechanisms in, live cells should be clearly known and predicted. A massive amount of experimental data dedicated to nanotoxicity has been accumulated to-date, but it lacks a logical structure. The current challenge is to organize existing knowledge into lucid biological and mathematical models. In our review we aim to describe the interplay of various cell death mechanisms triggered by quantum dots as a consequence of particle parameters and experimental conditions.
KAUST Catalysis Centre, King Abdullah University of Science & Technology, Thuwal Jeddah 23955-6900, Kingdom of Saudi Arabia.|School of Physics, National University of Ireland, Galway, Ireland.|CÚRAM - Centre for Research in Medical Devices, Galway, Ireland.
Olga
O
Gladkovskaya
CRANN & School of Chemistry, Trinity College Dublin, Ireland.|ITMO University, 197101 Saint Petersburg, Russia.
Yuri K
YK
Gun'ko
School of Physics, National University of Ireland, Galway, Ireland.
Gerard M
GM
O'Connor
Division of Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Box 210, 171 77 Stockholm, Sweden.|MV Lomonosov Moscow State University, 119991 Moscow, Russia.|Institute of Theoretical & Experimental Biophysics, Pushchino, 142290 Russia.
Vladimir
V
Gogvadze
CÚRAM - Centre for Research in Medical Devices, Galway, Ireland.|School of Chemistry, National University of Ireland, Galway, Ireland.|Sechenov First Moscow State Medical University, Institute for Regenerative Medicine.
Yury
Y
Rochev
D000818:Animals; D017209:Apoptosis; D001343:Autophagy; D016923:Cell Death; D002454:Cell Differentiation; D002470:Cell Survival; D006801:Humans; D049329:Nanostructures / Q000737:chemistry / Q000633:toxicity*; D009336:Necrosis; D045663:Quantum Dots / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*
apoptosis; nanotoxicity; necrosis; quantum dots