A variety of gene polymorphisms associated with idiopathic granulomatous mastitis.
Idiopathic granulomatous mastitis (IGM) is a rare and chronic inflammatory disorder. IGM mimics breast cancer regarding its clinical and radiological features. Etiology of IGM remains unclarified. Our patient was 37-year-old and 14 weeks pregnant. There was pain, redness and swelling in the right breast. The mass suggestive of malignancy was detected in sonography. Serum CA 125 and CA 15-3 levels were high. Genetic analysis was performed for the etiology. methylenetetrahydrofolate reductase (MTHFR) C 677 TT, β-fibrinogen-455 G>A, plasminogen activator inhibitor (PAI)-1 5 G/5 G, angiotensin-converting enzyme (ACE) I/D mutation was found. IGM was diagnosed by cor biopsy. An association was also reported between breast cancer and mutations in MTHFR-C 677 T, PAI-1, ACE genes. Genetic polymorphisms may involve in the development of IGM as it was seen in our case. Further studies should be conducted to better clarify this plausible association.
General Surgery Department, Emsey Hospital, Istanbul, Turkey.
Sebahattin
S
Destek
General Surgery Department, Edremit Military Hospital, Edremit , Balikesir, Turkey vonurgul@hotmail.com.
Vahit Onur
VO
Gul
Biochemistry Department, Edremit Military Hospital, Edremit, Balikesir , Turkey.
Serkan
S
Ahioglu