Pathophysiology of the disturbed angiogenesis in hemophilia.
BACKGROUND
It has been reported an increase of angiogenesis and vascular remodeling in hemophilic arthropathy. Therefore, antiangiogenic drugs could be useful in the management of hemophilic arthropathy. The aim of this review paper is to revise the role of angiogenesis in hemophilic arthropathy.


METHODS
This article is a narrative review of the pathophysiology of the disturbed angiogenesis in hemophilia and the potential role of antiangiogenic drugs in nonhemophilia patients Expert commentary: Antiangiogenic drugs could be helpful in the future for the treatment of hemarthroses in hemophilic arthropathy. However, despite some recent reports emphasizing the role of angiogenesis in hemophilia, as these drugs have never been investigated for the treatment of hemophilic arthropathy in PWH, it is clear that they are not indicated.
a Department of Orthopaedic Surgery , La Paz University Hospital , Madrid , Spain.
E Carlos
EC
Rodriguez-Merchan
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000818:Animals; D006395:Hemarthrosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D006467:Hemophilia A / Q000150:complications*; D002836:Hemophilia B / Q000150:complications*; D006801:Humans; D009389:Neovascularization, Pathologic / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*
D020533:Angiogenesis Inhibitors
Hemophilia; angiogenesis; antiangiogenic drugs; hemarthrosis; hemophilic arthropathy