Efficient one-pot synthesis of new 1-amino substituted pyrrolo[1,2-a]quinoline-4-carboxylate esters via copper-free Sonogashira coupling reactions.
The reactions of several 2-chloroquinoline-3-carboxylate esters with propargyl alcohol and a secondary amine in the presence of palladium catalyst leads to the formation of new alkyl 1-amino substituted pyrrolo[1,2-a]quinoline-4-carboxylate derivatives. This one-pot process, carried out in the absence of any copper salt, provides an efficient method for the synthesis of functionalized pyrrolo[1,2-a]quinolines in good-to-high yields.
School of Chemistry, Shahrood University of Technology, Shahrood, Iran. akeivanloo@yahoo.com.
Ali
A
Keivanloo
School of Chemistry, Shahrood University of Technology, Shahrood, Iran.
Shaghayegh Sadat
SS
Kazemi
School of Chemistry, Shahrood University of Technology, Shahrood, Iran.
Hossein
H
Nasr-Isfahani
Chemistry Faculty, University of Kashan, Kashan, Iran.
Abdolhamid
A
Bamoniri
D000480:Alkynes / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D004952:Esters; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry*
D000480:Alkynes; D002264:Carboxylic Acids; D004952:Esters; D011804:Quinolines
Copper-free; Palladium catalyst; Propargyl alcohol; Pyrrolo[1,2-a]quinoline; Sonogashira coupling