CRISPR as a driving force: the Model T of biotechnology.
The CRISPR system for gene editing can break, repair, and replace targeted sections of DNA. Although CRISPR gene editing has important therapeutic potential, it raises several ethical concerns. Some bioethicists worry CRISPR is a prelude to a dystopian future, while others maintain it should not be feared because it is analogous to past biotechnologies. In the scientific literature, CRISPR is often discussed as a revolutionary technology. In this paper we unpack the framing of CRISPR as a revolutionary technology and contrast it with framing it as a value-threatening biotechnology or business-as-usual. By drawing on a comparison between CRISPR and the Ford Model T, we argue CRISPR is revolutionary as a product, process, and as a force for social change. This characterization of CRISPR offers important conceptual clarity to the existing debates surrounding CRISPR. In particular, conceptualizing CRISPR as a revolutionary technology structures regulatory goals with respect to this new technology. Revolutionary technologies have characteristic patterns of implementation, entrenchment, and social impact. As such, early identification of technologies as revolutionary may help construct more nuanced and effective ethical frameworks for public policy.
Department of Philosophy, University of Nevada, Reno, Reno, NV, USA. carlos@philbio.org.
Carlos
http://orcid.org/0000-0001-6912-1319
C
Mariscal
Novel Tech Ethics, Department of Medicine, Dalhousie University, Halifax, NS, Canada.
Angel
A
Petropanagos
D064130:CRISPR-Associated Proteins / Q000235:genetics*; D064113:CRISPR-Cas Systems / Q000235:genetics*; D002869:Chromosome Aberrations; D004247:DNA / Q000235:genetics; D000072669:Gene Editing / Q000379:methods*; D016678:Genome / Q000235:genetics*; D006801:Humans; D008957:Models, Genetic
D064130:CRISPR-Associated Proteins; D004247:DNA
Biotechnology; CRISPR; CRISPR/Cas9; Gene editing; Gene therapy; Revolutionary technology