Initial Experience: Alleviation of Pain with Percutaneous CT-Guided Cryoablation for Recurrent Retroperitoneal Soft-Tissue Sarcoma.
OBJECTIVE
To evaluate the pain-alleviating effect of computed tomography (CT)-guided percutaneous cryoablation for recurrent retroperitoneal soft-tissue sarcomas (RPSs).


METHODS
Data from 19 men and 20 women (median age, 50.3 y) with recurrent malignant RPS who underwent percutaneous cryoablation were reviewed retrospectively. A total of 50 tumors were treated by cryoablation, including a single tumor in 29 patients, 2 tumors in 9, and 3 tumors in 1. Adverse events and analgesic outcomes were compared as a function of tumor size (< 10 cm and ≥ 10 cm). Efficacy was assessed based on modified Response Evaluation Criteria In Solid Tumors and progression-free survival (PFS).


RESULTS
Grade 1/2 adverse events included fever (n = 17), emesis (n = 7), frostbite (n = 5), and local pain (n = 4). The median follow-up period and PFS were 18.5 months (range, 12-42 mo) and 13.4 months ± 6.2, respectively. At the end of follow-up, 13 patients had died and 26 were living. The mean severe local pain scores on pretreatment day 1 and posttreatment days 1, 5, 10, 15, 20, and 25 were 7.49, 7.40, 6.51, 5.81, 5.35, 5.04, and 5.44, respectively, and significant differences versus pretreatment (P < .001) were reported for posttreatment days 5-25. Immediate relief occurred more frequently in the small-tumor group (4 of 7; 57.1%; P = .018), whereas delayed relief occurred more frequently in the large-tumor group (17 of 22; 77.3%; P = .030).


CONCLUSIONS
Minimally invasive percutaneous cryoablation improves local pain and is a feasible treatment for recurrent RPSs.
Departments of Interventional Oncology Guangzhou, China.
Wen-Zhe
WZ
Fan
Fuda Cancer Hospital, Jinan University School of Medicine, Guangzhou, China; Fuda Institute of Cryosurgery for Cancer, Guangzhou, China.
Li-Zhi
LZ
Niu
Departments of Interventional Oncology Guangzhou, China.
Yu
Y
Wang
Departments of Interventional Oncology Guangzhou, China.
Xue-Hua
XH
Yao
Departments of Interventional Oncology Guangzhou, China.
Ying-Qiang
YQ
Zhang
Interventional Radiology, Guangzhou, China.
Guo-Sheng
GS
Tan
Interventional Radiology, Guangzhou, China; Medical Imaging, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Jian-Yong
JY
Yang
Departments of Interventional Oncology Guangzhou, China. Electronic address: lijiaping_2011@126.com.
Jia-Ping
JP
Li
D015746:Abdominal Pain / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D000328:Adult; D000368:Aged; D000700:Analgesics / Q000627:therapeutic use; D002681:China; D003452:Cryosurgery / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D018572:Disease-Free Survival; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010147:Pain Measurement; D015641:Radiography, Interventional / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D012186:Retroperitoneal Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery*; D012189:Retrospective Studies; D012509:Sarcoma / Q000150:complications / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery*; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000009:adverse effects / Q000401:mortality; D016896:Treatment Outcome; D047368:Tumor Burden
D000700:Analgesics