Carbon ion radiotherapy for desmoid tumor of the abdominal wall: a case report.
BACKGROUND
Desmoid tumors, which are associated with familial adenomatous polyposis (FAP), tend to occur frequently in the abdominal wall and mesentery. Currently, there are no recognized treatments other than surgery, and frequent surgeries result in gastrointestinal obstructions and functional gastrointestinal disorders.


METHODS
After surgery that was performed on a 39-year-old patient with FAP, we performed a second tumor excision which was the procedure used for frequently occurring mesenteric desmoid tumors. It was determined that the enlarged tumor would be difficult to operate on through an abdominal incision. Subsequently, the carbon ion radiotherapy of 50 Gy was then performed on the patient. Three years later, the tumor still remains reduced in size. In addition, we have not observed any negative effect on the digestive tract.


CONCLUSIONS
This is the first instance that the carbon ion radiotherapy has been effective for the unresected desmoid tumor, and it is believed that this will become the one effective option for the treatment of desmoid tumors.
Department of Surgery and Science, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of To1yama, 2630 Sugitani, Toyama, 930-0194, Japan. naga0103@med.u-toyama.ac.jp.
Takuya
T
Nagata
Department of Radiology, Hyogo Ion Beam Medical Center, 1-2-1, Koto, Singu, Tatsuno, Hyogo, 679-5165, Japan.
Yusuke
Y
Demizu
Department of Surgery and Science, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of To1yama, 2630 Sugitani, Toyama, 930-0194, Japan.
Tomoyuki
T
Okumura
Department of Surgery and Science, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of To1yama, 2630 Sugitani, Toyama, 930-0194, Japan.
Shinichi
S
Sekine
Department of Radiation Oncology, Kobe Minimally Invasive Cancer Center, 8-5-1Minatojima, Tyuoku, Kobe, Hyogo, 650-0046, Japan.
Naoki
N
Hashimoto
Department of Radiation Oncology, Ise Red Cross Hospital, 1-471-2 Funae, Ise, Mie, 516-8512, Japan.
Nobukazu
N
Fuwa
Department of Radiology, Hyogo Ion Beam Medical Center, 1-2-1, Koto, Singu, Tatsuno, Hyogo, 679-5165, Japan.
Tomoaki
T
Okimoto
Department of Nanobio Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Shimoadachi, Yoshida, Sakyoku, Kyoto, 606-8501, Japan.
Yutaka
Y
Shimada
D034861:Abdominal Wall / Q000473:pathology; D011125:Adenomatous Polyposis Coli / Q000473:pathology / Q000601:surgery*; D003082:Colectomy / Q000009:adverse effects; D004385:Duodenostomy; D018221:Fibromatosis, Abdominal / Q000000981:diagnostic imaging / Q000532:radiotherapy* / Q000601:surgery; D018222:Desmoid Tumors / Q000000981:diagnostic imaging / Q000532:radiotherapy* / Q000601:surgery; D063193:Heavy Ion Radiotherapy; D006801:Humans; D007081:Ileostomy / Q000009:adverse effects; D007582:Jejunostomy; D008297:Male; D008643:Mesentery / Q000473:pathology; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D010534:Peritoneal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D000267:Tissue Adhesions / Q000150:complications / Q000209:etiology; D014057:Tomography, X-Ray Computed
Carbon ion radiotherapy; Desmoid tumor; Mesenteric; Unresectable