Preparation and characterization of novel β-chitin/nanodiopside/nanohydroxyapatite composite scaffolds for tissue engineering applications.
β-chitin/nanodiopside/nanohydroxyapatite (CT/nDP/nHAp) composite scaffolds were synthesized from the combination of chitin, nDP, and nHAp in different inorganic/organic weight ratios by the freeze-drying technique. The prepared nHAp, and composite scaffolds were characterized by BET, TG, FT-IR, SEM, and XRD studies. The composite scaffolds had 50-75% porosities with well-defined interconnected porous networks. Moreover, investigation of the cell attachment and viability using MTT, DMEM solution, and mouse preosteoblast cell proved the cytocompatibile nature of the composite scaffolds with improved cell adhesion. All these results mainly illustrated that this composite could be a candidate for bone tissue engineering application.
a Chemistry Department , Payame Noor University , Tehran , Iran.
Abbas
A
Teimouri
a Chemistry Department , Payame Noor University , Tehran , Iran.
Mohammad
M
Azadi
b Faculty of Science, Department of Chemistry , University of Birjand , Birjand , Iran.
Zahra
Z
Shams Ghahfarokhi
c Department of Biology , Payame Noor University , Tehran , Iran.
Roya
R
Razavizadeh
D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D002686:Chitin / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D008422:Materials Testing; D055595:Mechanical Phenomena; D012824:Silicic Acid / Q000737:chemistry*; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry*
D001672:Biocompatible Materials; D012824:Silicic Acid; D002686:Chitin; C074224:diopside; D017886:Durapatite
Chitin; composite scaffold; nanodiopside; nanohydroxyapatite; tissue engineering