Metabolic reprogramming of myeloid-derived suppressor cells (MDSC) in cancer.
MDSC undergo metabolic reprogramming in the tumor resulting in an increased fatty acid β oxidation that supports their immunosuppressive functions. Fatty acid oxidation inhibitors, used to treat coronary disease, significantly delayed tumor growth and had a significantly increased antitumor effect when combined with adoptive cell therapy or low dose chemotherapy.
Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Amir A
AA
Al-Khami
Georgia Regents University Cancer Center , Augusta, GA, USA.
Paulo C
PC
Rodriguez
Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA; Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Augusto C
AC
Ochoa
Cancer; Immunometabolism; MDSC