Research progress on chemopreventive effects of phytochemicals on colorectal cancer and their mechanisms.
Colorectal cancer (CRC) is a type of cancer with high morbidity and mortality rates worldwide and has become a global health problem. The conventional radiotherapy and chemotherapy regimen for CRC not only has a low cure rate but also causes side effects. Many studies have shown that adequate intake of fruits and vegetables in the diet may have a protective effect on CRC occurrence, possibly due to the special biological protective effect of the phytochemicals in these foods. Numerous in vitro and in vivo studies have demonstrated that phytochemicals play strong antioxidant, anti-inflammatory and anti-cancer roles by regulating specific signaling pathways and molecular markers to inhibit the occurrence and development of CRC. This review summarizes the progress on CRC prevention using the phytochemicals sulforaphane, curcumin and resveratrol, and elaborates on the specific underlying mechanisms. Thus, we believe that phytochemicals might provide a novel therapeutic approach for CRC prevention, but future clinical studies are needed to confirm the specific preventive effect of phytochemicals on cancer.
Teng-Fei Yin, Min Wang, Ying Qing, Department of Gastroenterology, Geriatrics, Qi-Lu Hospital of Shandong University, Jinan 250012, Shandong Province, China.
Teng-Fei
TF
Yin
Teng-Fei Yin, Min Wang, Ying Qing, Department of Gastroenterology, Geriatrics, Qi-Lu Hospital of Shandong University, Jinan 250012, Shandong Province, China.
Min
M
Wang
Teng-Fei Yin, Min Wang, Ying Qing, Department of Gastroenterology, Geriatrics, Qi-Lu Hospital of Shandong University, Jinan 250012, Shandong Province, China.
Ying
Y
Qing
Teng-Fei Yin, Min Wang, Ying Qing, Department of Gastroenterology, Geriatrics, Qi-Lu Hospital of Shandong University, Jinan 250012, Shandong Province, China.
Ying-Min
YM
Lin
Teng-Fei Yin, Min Wang, Ying Qing, Department of Gastroenterology, Geriatrics, Qi-Lu Hospital of Shandong University, Jinan 250012, Shandong Province, China.
Dong
D
Wu
D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D017209:Apoptosis; D059447:Cell Cycle Checkpoints; D015179:Colorectal Neoplasms / Q000098:blood supply / Q000473:pathology / Q000517:prevention & control*; D003474:Curcumin / Q000627:therapeutic use; D006801:Humans; D051267:NF-E2-Related Factor 2 / Q000502:physiology; D009389:Neovascularization, Pathologic / Q000517:prevention & control; D064209:Phytochemicals / Q000627:therapeutic use*; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use
D016588:Anticarcinogenic Agents; D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human; D064209:Phytochemicals; D013267:Stilbenes; D003474:Curcumin; D000077185:Resveratrol
Chemopreventive effects; Colorectal cancer; Curcumin; Molecular mechanism; Phytochemicals; Resveratrol; Sulforaphane