Treatment-associated change in apelin concentration in patients with hypertension and its relationship with left ventricular diastolic function.
We examined the change in apelin concentration and its relationship with left ventricular diastolic function in patients treated for hypertension.



Ninety treatment-naive patients with newly diagnosed hypertension and 33 age- and sex-matched control subjects were prospectively enrolled. Patients with hypertension were randomized to treatment either with telmisartan 80 mg or amlodipine 10 mg. Apelin concentration was measured and echocardiography was performed at baseline and after 1 month of treatment.



The data of 77 patients and 33 controls were analyzed. Mean age, gender, baseline blood pressure, apelin levels, and echocardiographic measurements were similar between the treatment groups (p>0.05 for all). Apelin concentration was significantly lower in patients with hypertension than in controls. There was a significant increase in apelin level after 1 month of treatment in both groups (0.32±0.17 vs. 0.38±0.17 ng/dL in telmisartan group, p=0.009, and 0.27±0.13 vs. 0.34±0.18 ng/dL in amlodipine group, p=0.013). Diastolic function improved significantly in both groups (p<0.05) but was not significantly associated with change in apelin concentration.



Apelin concentration increased significantly after 1 month of effective treatment with telmisartan or amlodipine to a similar extent. Change in apelin concentration was not associated with improvement in diastolic function.
Department of Cardiology, Faculty of Medicine, Başkent University; Ankara-Turkey. sselcukbaysal@gmail.com.
Sadettin Selçuk
SS
Baysal
Department of Cardiology, Faculty of Medicine, Başkent University; Ankara-Turkey.
Bahar
B
Pirat
Department of Cardiology, Faculty of Medicine, Başkent University; Ankara-Turkey.
Kaan
K
Okyay
Department of Cardiology, Faculty of Medicine, Başkent University; Ankara-Turkey.
Uğur Abbas
UA
Bal
Department of Cardiology, Faculty of Medicine, Başkent University; Ankara-Turkey.
Melek Zekiye
MZ
Uluçam
Department of Biostatistics, Faculty of Medicine, Ankara University; Ankara-Turkey.
Derya
D
Öztuna
Department of Cardiology, Faculty of Medicine, Başkent University; Ankara-Turkey.
Haldun
H
Müderrisoğlu
D017311:Amlodipine / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D000073861:Apelin / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D004452:Echocardiography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D000077333:Telmisartan / Q000627:therapeutic use; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000000981:diagnostic imaging
D000959:Antihypertensive Agents; D000073861:Apelin; D015415:Biomarkers; D017311:Amlodipine; D000077333:Telmisartan