Dual ions implantation of zirconium and nitrogen into magnesium alloys for enhanced corrosion resistance, antimicrobial activity and biocompatibility.
Biodegradable magnesium-based alloys have shown great potential for medical applications due to their superior biological performances and mechanical properties. However, on one hand, some side effects including inferior biocompatibility, a local high-alkaline environment and gas cavities caused by a rapid corrosion rate, hinder their clinical application. On the other hand, it is also necessary to endow Mg alloys with antibacterial properties, which are crucial for clinic orthopedic applications. In this study, Zr and N ions are simultaneously implanted into AZ91 Mg alloys by plasma immersion ion implantation (PIII). A modified layer with a thickness of approximately 80nm is formed on the surface of AZ91 Mg alloys, and the hydrophobicity and roughness of these AZ91 Mg alloys obviously increase after Zr and N implantation. The in vitro evaluations including corrosion resistance tests, antimicrobial tests and cytocompatibility and alkaline phosphatase (ALP) activity tests, revealed that the dual ions implantation of Zr and N not only enhanced the corrosion resistance of the AZ91 Mg alloy but also provided better antimicrobial properties in vitro. Furthermore, the formation of biocompatible metal nitrides and metal oxides layer in the near surface of the Zr-N-implanted AZ91 Mg alloy provided a favorable implantation surface for cell adhesion and growth, which in return further promoted the bone formation in vivo. These promising results suggest that the Zr-N-implanted AZ91 Mg alloy shows potential for future application in the orthopedic field.
Department of Orthopedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China.
Mengqi
M
Cheng
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
Yuqin
Y
Qiao
Department of Orthopedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China.
Qi
Q
Wang
Department of Orthopedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China.
Hui
H
Qin
Department of Orthopedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China. Electronic address: zhangxianl197826@163.com.
Xianlong
X
Zhang
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China. Electronic address: xyliu@mail.sic.ac.cn.
Xuanyong
X
Liu
D000497:Alloys; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001672:Biocompatible Materials; D002460:Cell Line; D003343:Corrosion; D005260:Female; D008274:Magnesium / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015040:Zirconium / Q000737:chemistry*
D000497:Alloys; D000890:Anti-Infective Agents; D001672:Biocompatible Materials; D015040:Zirconium; D008274:Magnesium; D009584:Nitrogen
Antibacterial property; Corrosion resistance; Magnesium alloys; Osseointegration; Plasma ion implantation