Osteopontin in relation to Prognosis following Coronary Artery Bypass Graft Surgery.
Cardiovascular events may occur even after complete revascularization in patients with coronary artery disease. We measured preoperative osteopontin (OPN) levels in 131 consecutive patients (66.5 ± 10 years old, 117 men and 14 women) with left ventricular ejection fraction of 50.7 ± 9.2% and low logistic EuroScore (3.5 ± 3.2%) undergoing elective Coronary Artery Bypass Grafting (CABG) surgery. Patients were prospectively followed up for a median of 12 months (range 11-24). The primary study endpoint was the composite of cardiovascular death, nonfatal myocardial infarction, need for repeat revascularization, and hospitalization for cardiovascular events. Pre-op OPN plasma levels were 77.9 (49.5, 150.9). Patients with prior acute myocardial infarction (AMI) had significantly higher OPN levels compared to those without [131.5 (52.2, 219) versus 73.3 (45.1, 125), p = 0.007]. OPN levels were positively related to EuroScore (r = 0.2, p = 0.031). Pre-op OPN levels did not differ between patients who had a major adverse event during follow-up compared to those with no event (p = 0.209) and had no effect on the hazard of future adverse cardiac events [HR (95% CI): 1.48 (0.43-4.99), p = 0.527]. The history of AMI was associated with increased risk of subsequent cardiovascular events at follow-up (p = 0.02). OPN is associated with preoperative risk assessment prior to low-risk CABG but did not independently predict outcome.
2nd Division of Interventional Cardiology, Onassis Cardiac Surgery Center, 17674 Athens, Greece.
Eftihia
E
Sbarouni
2nd Division of Interventional Cardiology, Onassis Cardiac Surgery Center, 17674 Athens, Greece.
Panagiota
0000-0002-5436-3144
P
Georgiadou
2nd Division of Interventional Cardiology, Onassis Cardiac Surgery Center, 17674 Athens, Greece.
Sofia
S
Chatzikyriakou
Department of Hygiene, Epidemiology and Medical Statistics, Medical School, University of Athens, 11527 Athens, Greece.
Antonis
A
Analitis
Molecular Immunopathology and Histocompatibility Laboratory, Onassis Cardiac Surgery Center, 17674 Athens, Greece.
Antigoni
A
Chaidaroglou
Molecular Immunopathology and Histocompatibility Laboratory, Onassis Cardiac Surgery Center, 17674 Athens, Greece.
Demitris
D
Degiannis
2nd Division of Interventional Cardiology, Onassis Cardiac Surgery Center, 17674 Athens, Greece.
Vassilis
V
Voudris
D000368:Aged; D015415:Biomarkers / Q000097:blood; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000601:surgery; D053495:Osteopontin / Q000097:blood*
D015415:Biomarkers; D053495:Osteopontin