Prevalence and lethality among patients with histoplasmosis and AIDS in the Midwest Region of Brazil.
Histoplasmosis is a systemic mycosis that is considered an important public health problem. In this work, we performed a descriptive, observational, cross-sectional and retrospective study with a secondary data analysis of medical records from 2000 to 2012 at a tertiary hospital. The study sample consisted of 275 patients with laboratory-confirmed Disseminated Histoplasmosis (DH)/AIDS. The results showed that the prevalence of DH associated with AIDS was 4.4%. The majority of patients were young adult men with fever in 84.2%, cough in 63.4%, weight loss in 63.1%, diarrhoea in 44.8% and skin manifestations in 27.6% of patients. In the overall cohort, the CD4 counts were low, but not significantly different in survivors and non-survivors. Higher levels of urea and lower levels of haemoglobin and platelets were observed in non-survivor patients (<.05). The global lethality was 71.3% (196/275). The results with high prevalence and lethality highlight the need to adopt measures to facilitate early diagnosis, proper treatment and improved prognosis.
Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiania, Goiás, Brazil.
Thaísa C
http://orcid.org/0000-0002-9595-3319
TC
Silva
Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiania, Goiás, Brazil.
Carolina M
CM
Treméa
Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiania, Goiás, Brazil.
Ana Laura S A
AL
Zara
Hospital of Tropical Diseases "Dr. Anuar Auad", Goiania, Goiás, Brazil.
Ana Flávia
AF
Mendonça
Hospital of Tropical Diseases "Dr. Anuar Auad", Goiania, Goiás, Brazil.
Cássia S M
CS
Godoy
Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiania, Goiás, Brazil.
Carolina R
CR
Costa
Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiania, Goiás, Brazil.
Lúcia K H
LK
Souza
Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiania, Goiás, Brazil.
Maria R R
MR
Silva
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000453:epidemiology / Q000401:mortality; D000293:Adolescent; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D001938:Brazil / Q000453:epidemiology; D018791:CD4 Lymphocyte Count; D002648:Child; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006660:Histoplasmosis / Q000188:drug therapy / Q000453:epidemiology* / Q000401:mortality; D006801:Humans; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D009894:Opportunistic Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000401:mortality; D010976:Platelet Count; D015995:Prevalence; D012189:Retrospective Studies; D062606:Tertiary Care Centers / Q000706:statistics & numerical data; D014508:Urea / Q000032:analysis; D055815:Young Adult
D000935:Antifungal Agents; D006454:Hemoglobins; D014508:Urea

AIDS
; histoplasmosis; prevalence