Changes of Platelet Indices in Juvenile Idiopathic Arthritis in Acute Phase and After Two Months Treatment.
BACKGROUND
Various indices have been raised as predictors of activity and severity of juvenile idiopathic arthritis.


OBJECTIVE
This study was conducted to investigate the changes of platelet indices in acute phase and two months after treatment in these patients.


METHODS
In a cohort study, platelet count, mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT) were evaluated in children referred to children's medical center, Tehran due to juvenile idiopathic arthritis from March 2013 to March 2014 during the acute phase and two months after standard treatment. The statistical data were analyzed by SPSS 19 software, and the significance level was set as P < 0.05.


RESULTS
In this study, 55 children (24 boys and 31 girls) with mean ± SD age of 7.50 ± 3.35 years were studied. The mean ± SD value of platelet count was 441872.7 ± 151836.9 in the acute phase and reached 395418.2 ± 119601.6 two months after treatment (P = 0.01). The mean ± SD PCT in the acute phase of various subtypes of the disease was 0.32 ± 0.11, which reached 0.29 ± 0.10 after treatment (P = 0.09). However, the PDW range in different subtypes of the disease reached 13.4 ± 8.0 from 13.9 ± 2.9 and MPV reached 8.7 ± 0.9 from 8.8 ± 1.1 after treatment, but they were not significantly different from the results in the acute phase (P = 0.5).


CONCLUSIONS
Platelet count is one of the most remarkable indices in JIA. Evaluation of PCT can also help determine the severity of the inflammatory process in the follow-up and treatment process.
Children's Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, IR Iran.
Marjan
M
Vakili
Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, IR Iran; Department of Pediatrics, Tehran University of Medical Sciences, Tehran, IR Iran.
Vahid
V
Ziaee
Children's Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, IR Iran; Department of Pediatrics, Tehran University of Medical Sciences, Tehran, IR Iran.
Mohammad Hassan
MH
Moradinejad
Department of Pediatrics, Tehran University of Medical Sciences, Tehran, IR Iran.
Seyed Reza
SR
Raeeskarami
Children's Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, IR Iran; Department of Pediatrics, Tehran University of Medical Sciences, Tehran, IR Iran.
Farzad
F
Kompani
Children's Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, IR Iran.
Tayebeh
T
Rahamooz
Acute Phase Reactants; Juvenile Idiopathic Arthritis; Mean Platelet Volume; Platelet Count; Platelet Indices