Copper-Catalyzed Aerobic Cascade Oxidative Coupling/Cyclization for the Construction of 1,4-Dihydropyridine Derivatives.
An efficient copper-catalyzed cascade cyclization reaction for the preparation of polysubstituted 1,4-dihydropyridines between N-arylglycine esters and 1,3-dicarbonyl compounds using molecular oxygen as the terminal oxidant has been described. Various N-arylglycine esters 1 and 1,3-dicarbonyl compounds 2 were able to undergo the cascade reaction smoothly to afford the desired products 3 in satisfactory yields. The cascade reaction has the advantages of good functional group tolerance and mild reaction conditions. A possible mechanism has also been proposed on the basis of control experiments.
Jiangxi 2011 Joint Center for the Innovative Mass Spectrometry and Instrumentation and ‡School of Chemistry, Biology and Material Science, East China University of Technology , Nanchang 330013, P. R. China.
Zhi-Qiang
ZQ
Zhu
Jiangxi 2011 Joint Center for the Innovative Mass Spectrometry and Instrumentation and ‡School of Chemistry, Biology and Material Science, East China University of Technology , Nanchang 330013, P. R. China.
Zong-Bo
ZB
Xie
Jiangxi 2011 Joint Center for the Innovative Mass Spectrometry and Instrumentation and ‡School of Chemistry, Biology and Material Science, East China University of Technology , Nanchang 330013, P. R. China.
Zhang-Gao
ZG
Le