[Rocky Mountain spotted fever in Mexican children: Clinical and mortality factors].
OBJECTIVE
Characterize clinical manifestations and predictors of mortality in children hospitalized for spotted fever.


METHODS
Cross-sectional study in 210 subjects with a diagnosis of Rocky Mountain spotted fever (RMSF) in a pediatric hospital in Sonora, from January 1st, 2004 to June 30th, 2015. Data were analyzed using descriptive statistics and multivariate logistic regression.


RESULTS
An upward trend was observed in RMSF morbidity and mortality. Fatality rate was 30%.Three predictors were associated with risk of death: delay ≥ 5 days at the start of doxycycline (ORa= 2.95, 95% CI 1.10-7.95), acute renal failure ((ORa= 8.79, 95% CI 3.46-22.33) and severe sepsis (ORa= 3.71, 95% CI 1.44-9.58).


CONCLUSIONS
RMSF causes high mortality in children, which can be avoided with timely initiation of doxycycline. Acute renal failure and severe sepsis are two independent predictors of death in children with RMSF.
Gerardo
G
Álvarez-Hernández
María Del Carmen
Mdel C
Candia-Plata
Jesús
J
Delgado-de la Mora
Natalia Haydeé
NH
Acuña-Meléndrez
Anabel Patricia
AP
Vargas-Ortega
Jesús David
JD
Licona-Enríquez
D058186:Acute Kidney Injury / Q000209:etiology / Q000401:mortality; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008800:Mexico / Q000453:epidemiology; D009017:Morbidity / Q000639:trends; D009026:Mortality / Q000639:trends; D012307:Risk Factors; D012373:Rocky Mountain Spotted Fever / Q000150:complications / Q000453:epidemiology* / Q000401:mortality; D018805:Sepsis / Q000209:etiology / Q000401:mortality