Identification of differentially expressed genes affecting hair and cashmere growth in the Laiwu black goat by microarray.
Goats are an important source of fibers. In the present study microarray technology was used to investigate the potential genes primarily involved in hair and cashmere growth in the Laiwu black goat. A total of 655 genes differentially expressed in body (hair‑growing) and groin (hairless) skin were identified, and their potential association with hair and cashmere growth was analyzed. The majority of genes associated with hair growth regulation could be assigned to intracellular, intracellular organelle, membrane‑bound vesicle, cytoplasmic vesicle, pattern binding, heparin binding, polysaccharide binding, glycosaminoglycan binding and cytoplasmic membrane‑bound vesicle categories. Numerous genes upregulated in body compared with groin skin contained common motifs for nuclear factor 1A, Yi, E2 factor (E2F) and cyclic adenosine monophosphate response element binding (CREB)/CREBβ binding sites in their promoter region. The promoter region of certain genes downregulated in body compared with groin skin contained three common regions with LF‑A1, Yi, E2F, Collier/Olfactory‑1/early B‑cell factor 1, peroxisome proliferator‑activated receptor α or U sites. Thus, the present study identified molecules in the cashmere‑bearing skin area of the Laiwu black goat, which may contribute to hair and cashmere traits.
College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, Shandong 266109, P.R. China.
Jinshan
J
Zhao
College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, Shandong 266109, P.R. China.
Hegang
H
Li
Department of Reproduction and Breeding, Qingdao Institute of Animal Science and Veterinary Medicine, Qingdao, Shandong 266100, P.R. China.
Kaidong
K
Liu
Department of Reproduction and Breeding, Qingdao Institute of Animal Science and Veterinary Medicine, Qingdao, Shandong 266100, P.R. China.
Baoxun
B
Zhang
Department of Reproduction and Breeding, Qingdao Institute of Animal Science and Veterinary Medicine, Qingdao, Shandong 266100, P.R. China.
Peipei
P
Li
College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, Shandong 266109, P.R. China.
Jianning
J
He
Department of Reproduction and Breeding, Qingdao Institute of Animal Science and Veterinary Medicine, Qingdao, Shandong 266100, P.R. China.
Ming
M
Cheng
College of Basic Medicine, Nanjing Medical University, Nanjing, Jiangsu 210002, P.R. China.
Wei
W
De
College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, Shandong 266109, P.R. China.
Jifeng
J
Liu
College of Biology, China Agricultural University, Beijing 100193, P.R. China.
Yaofeng
Y
Zhao
College of Biotechnology, Inner Mongolia Agricultural University, Hohhot, Nei Mongol Autonomous Region 010018, P.R. China.
Lihua
L
Yang
College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, Shandong 266109, P.R. China.
Nan
N
Liu
D000822:Animal Husbandry; D000818:Animals; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D006041:Goats / Q000235:genetics* / Q000254:growth & development*; D006197:Hair / Q000254:growth & development* / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D012867:Skin / Q000378:metabolism; D059467:Transcriptome