Breastfeeding and IL-10 levels in children affected by cow's milk protein allergy: A restrospective study.
To assess the protective role of breast-feeding in infants with CMPA-related AEDS as well as IL-10 utility as marker of disease evolution.



64 breast-feeding children with CMPA-related AEDS (31 males and 33 females; mean age 5.56±2.41months; 21 mild AEDS; 25 moderate AEDS; 18 severe AEDS) and 60 artificial feeding babies (33 males and 27 females; mean age 6.01±2.08months; 26 mild AEDS; 19 moderate AEDS; 15 severe AEDS) were evaluated. In all patients serum IL-10 levels were detected.



Significant Score Atopic Dermatitis (SCORAD) index point differences between breastfed and not breastfed children (p<0.001) have been detected. The serum IL-10 levels were lower in children with CMPA-related AEDS as compared to the healthy control group (p<0.001). Moreover, a significant inverse correlation between serum IL-10 levels and SCORAD in both enrolled groups has been also noted. In particular, IL-10 levels, in both groups, were significantly lower in children with severe symptoms. Conversely, serum IL-10 levels were significantly increased in children with mild-severe symptoms in both groups. Furthermore, breastfed children, with lower severe symptoms, had higher serum IL-10 levels. Finally, serum total IgE levels were negatively correlated with serum IL-10 levels in both breastfed and non-breastfed children with CMPA-related AEDS (p<0.001).



We reported that exclusive breast-feeding induces hyposensitization in children with CMPA-related AEDS and it is associated with minor disease severity and higher serum IL-10 levels, resulting as useful disease-monitor marker.
Department of Pediatric Sciences, University of Messina, Messina, Italy. Electronic address: saramanti@hotmail.it.
Sara
S
Manti
Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, Department of Clinical and Experimental Sciences, University of Brescia, Spedali Civili di Brescia, Italy.
Vassilios
V
Lougaris
Department of Pediatric Sciences, University of Messina, Messina, Italy.
Caterina
C
Cuppari
Department of Medical and Pediatric Science, Unit of Broncho-Pneumology and Cystic Fibrosis, University of Catania, Catania, Italy.
Lucia
L
Tardino
Department of Pediatric Sciences, University of Messina, Messina, Italy.
Valeria
V
Dipasquale
Department of Pediatric Sciences, University of Messina, Messina, Italy.
Teresa
T
Arrigo
Department of Pediatric Sciences, University of Messina, Messina, Italy.
Carmelo
C
Salpietro
Department of Medical and Pediatric Science, Unit of Broncho-Pneumology and Cystic Fibrosis, University of Catania, Catania, Italy.
Salvatore
S
Leonardi
D000485:Allergens / Q000276:immunology*; D000818:Animals; D015415:Biomarkers; D001942:Breast Feeding; D002417:Cattle; D002675:Child, Preschool; D016207:Cytokines / Q000097:blood; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D007223:Infant; D016753:Interleukin-10 / Q000097:blood*; D008297:Male; D008892:Milk / Q000009:adverse effects*; D016269:Milk Hypersensitivity / Q000097:blood* / Q000175:diagnosis / Q000209:etiology*; D008894:Milk Proteins / Q000276:immunology*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D012882:Skin Tests
D000485:Allergens; D015415:Biomarkers; D016207:Cytokines; D008894:Milk Proteins; D016753:Interleukin-10; D007073:Immunoglobulin E
Breast-feeding; Cow’s milk protein allergy; Immune tolerance; Interleukin-10