Association of MBL2 exon1 polymorphisms with high-risk human papillomavirus infection and cervical cancers: a meta-analysis.
High-risk human papillomavirus (HR-HPV) infection is the main known cause of cervical cancer. Mannose-binding lectin (MBL) is a recognition molecule that mediates phagocytosis and activates complement.



We performed a meta-analysis to investigate the association of MBL-2 functional polymorphisms with HPV infection and cervical cancer (CC).



The meta-analyses indicated an association between the MBL2 exon 1 polymorphisms and susceptibility to HPV infection in the recessive model (OO vs. AA + AO, p = 0.042, 95 % CI 1.02-3.15), and O/O vs. A/A mode (P = 0.023, 95 % CI 1.10-3.40) in Caucasian. Meanwhile, there was a significant association between MBL2 exon 1 polymorphisms and cervical cancer risk in AO vs. AA model (p = 0.035, 95 % CI 1.03-2.26), and Allelic model (O vs. A, p = 0.022, 95 % CI 1.05-1.96) as compared to HR-HPV-infected patients with CC vs. healthy controls in Caucasian. In addition, no an association was observed between MBL2 -550 H/L and -221 X/Y polymorphisms and HPV infection among Caucasians, but we found an association between the MBL2 -550 H/L polymorphism and susceptibility to HR-HPV infection in recessive model (HH vs. LL + LH, p = 0.003, 95 % CI 1.18-2.23), HH vs. LL model (p = 0.021, 95 % CI 1.07-2.19), and allelic model(H vs. L, p = 0.042, 95 % CI 1.01-1.40) in Asians.



Collectively, we suggest that the MBL2 gene exon1 polymorphisms are associated with increased risk of high-risk HPV infection and cervical cancer development among Caucasians. Additionally, no significant association was found between the MBL2 -550 H/L or -221 X/Y polymorphisms and HPV infection in Caucasians, but there may be potential links in Asians.
Department of Genetics and Molecular Biology, Xi'an Jiaotong University School of Medicine, Xi'an, 710061, Shaanxi, People's Republic of China. hlianw@mail.xjtu.edu.cn.|Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an, 710061, Shaanxi, People's Republic of China. hlianw@mail.xjtu.edu.cn.
Hui-Lian
HL
Wang
School of Mechanical Engineering, Xi'an Jiaotong University, Xi'an, 710049, Shaanxi, People's Republic of China.
Xi
X
Lu
Department of Genetics and Molecular Biology, Xi'an Jiaotong University School of Medicine, Xi'an, 710061, Shaanxi, People's Republic of China.|Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an, 710061, Shaanxi, People's Republic of China.
Xudong
X
Yang
2nd Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, 710004, Shaanxi, People's Republic of China.
Nan
N
Xu
D005091:Exons; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D037601:Mannose-Binding Lectin / Q000235:genetics*; D030361:Papillomavirus Infections / Q000235:genetics* / Q000473:pathology*; D011110:Polymorphism, Genetic; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology / Q000821:virology*
C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin
Cervical cancer; Human papillomavirus; Mannose-binding lectin 2; Mannose-binding protein; Polymorphism