The Influence of the Type of Continuous Exercise Stress Applied during Growth Periods on Bone Metabolism and Osteogenesis.
BACKGROUND
In this study, we examined the influence of exercise loading characteristics on bone metabolic responses and bone morphology in the growth phase and adulthood.


METHODS
Running exercise (RUN) and jumping exercise (JUM) were used for the exercise loading in 28-day-old male Wistar rats. Bone metabolism was measured by blood osteocalcin (OC) and tartrate-resistant acid phosphatase (TRACP) levels. For bone morphology, the maximum bone length, bone weight, and bone strength of the femur and tibia were measured.


RESULTS
A pre- and post-exercise loading comparison in the growth phase showed significantly increased OC levels in the RUN and JUM groups and significantly decreased TRACP levels in the JUM group. On the other hand, a pre- and post-exercise loading comparison in adulthood showed significantly decreased TRACP levels in the RUN and JUM groups. Femur lengths were significantly shorter in the RUN and JUM groups than in the control (CON) group, while bone weight was significantly greater in the JUM group than in the CON group.


CONCLUSIONS
Exercise loading activates OC levels in the growth phase and suppresses TRACP levels in adulthood. On the other hand, these results suggest that excessive exercise loading may suppress bone length.
Department of Physical Therapy, Aomori University of Health and Welfare, Aomori, Japan.
Sangun
S
Lee
Department of Physical Therapy, Aomori University of Health and Welfare, Aomori, Japan.
Takao
T
Suzuki
Department of Nutrition, Aomori University of Health and Welfare, Aomori, Japan.
Hiromi
H
Izawa
Department of Nursing, Hirosaki University of Health and Welfare, Hirosaki, Japan.
Atsuko
A
Satoh
Exercise; Growth; Osteoblasts; Osteoclasts; Osteogenesis; Stress mechanical