Combining Text Messaging and Telephone Counseling to Increase Varenicline Adherence and Smoking Abstinence Among Cigarette Smokers Living with HIV: A Randomized Controlled Study.
Smoking represents an important health risk for people living with HIV (PLHIV). Low adherence to smoking cessation pharmacotherapy may limit treatment effectiveness. In this study, 158 participants recruited from three HIV care centers in New York City were randomized to receive 12-weeks of varenicline (Chantix) either alone as standard care (SC) or in combination with text message (TM) support or TM plus cell phone-delivered adherence-focused motivational and behavioral therapy (ABT). Generalized linear mixed-effect models found a significant decline in varenicline adherence from week 1-12 across treatment groups. At 12-weeks, the probability of smoking abstinence was significantly higher in SC+TM+ABT than in SC. The study demonstrates the feasibility of delivering adherence-focused interventions to PLHIV who smoke. Findings suggest intensive behavioral support is an important component of an effective smoking cessation intervention for this population, and a focus on improving adherence self-efficacy may lead to more consistent adherence and higher smoking abstinence.
Department of Population Health, New York University School of Medicine, 227 East 30th Street, Room 708, New York, NY, 10016, USA.
Tuo-Yen
TY
Tseng
Department of Population Health, New York University School of Medicine, 227 East 30th Street, Room 708, New York, NY, 10016, USA.
Paul
P
Krebs
Department of Population Health, New York University School of Medicine, 227 East 30th Street, Room 708, New York, NY, 10016, USA.
Antoinette
A
Schoenthaler
Department of Population Health, New York University School of Medicine, 227 East 30th Street, Room 708, New York, NY, 10016, USA.
Selena
S
Wong
Department of Population Health, New York University School of Medicine, 227 East 30th Street, Room 708, New York, NY, 10016, USA.
Scott
S
Sherman
Department of Population Health, New York University School of Medicine, 227 East 30th Street, Room 708, New York, NY, 10016, USA.
Mirelis
M
Gonzalez
Behavioral Health Research, St. Luke's Roosevelt Hospital, New York, NY, USA.
Antonio
A
Urbina
New York University Rory Meyers College of Nursing and Center for Drug Use and HIV Research, New York, NY, USA.
Charles M
CM
Cleland
Department of Population Health, New York University School of Medicine, 227 East 30th Street, Room 708, New York, NY, 10016, USA. donna.shelley@nyumc.org.
Donna
D
Shelley
D000328:Adult; D001521:Behavior Therapy / Q000379:methods*; D040421:Cell Phone; D003376:Counseling; D005260:Female; D015658:HIV Infections / Q000453:epidemiology*; D006801:Humans; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D062405:Motivational Interviewing / Q000379:methods*; D009519:New York City / Q000453:epidemiology; D018722:Nicotinic Agonists / Q000627:therapeutic use*; D012107:Research Design; D012907:Smoking / Q000453:epidemiology / Q000628:therapy*; D016540:Smoking Cessation / Q000379:methods*; D013689:Telephone; D060145:Text Messaging; D016896:Treatment Outcome; D000068580:Varenicline / Q000627:therapeutic use*
D018722:Nicotinic Agonists; D000068580:Varenicline
HIV; Medication adherence; Smoking cessation; Telephone counseling; Text messaging