Cumulative High-Grade Squamous Intraepithelial Lesion Rate and Need for Surgical Intervention of Atypical Squamous Cells of Undetermined Significance Cytology-Diagnosed Patients: A Prospective Study.
OBJECTIVE
Τhe study aimed to study the rate of atypical squamous cells of undetermined significance (ASCUS) that progressed to high-grade squamous intraepithelial lesions (HGSIL), as well as the number of patients who finally necessitated a surgical intervention during follow-up.


METHODS
A prospective study was conducted on patients admitted for colposcopy during 2007-2012. We exclusively included those who presented with newly ASCUS diagnosis, while patients with a history of cervical intraepithelial neoplasia (CIN) were excluded. Primary end points were the cumulative rate of HGSIL during follow-up and the rate of surgical procedures performed because of such lesions.


RESULTS
There were 134 ASCUS cases included. Overall, there were 48 (35.8%) surgical excision procedures performed to treat or eliminate HGSIL during the follow-up period. According to the final histopathology of surgical specimens, the cumulative rate of CIN2 or higher cervical lesions was 28.4% (n = 38).


CONCLUSIONS
The cumulative rate of CIN2+ during follow-up period was almost 30% for patients with ASCUS, with the necessity for interventional treatment being even higher.
3rd Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Stamatios
S
Petousis
Ioannis
I
Kalogiannidis
Chrysoula
C
Margioula-Siarkou
Apostolos
A
Mamopoulos
George
G
Mavromatidis
Nikolaos
N
Prapas
David
D
Rousso
D000328:Adult; D000368:Aged; D065309:Atypical Squamous Cells of the Cervix / Q000473:pathology*; D003127:Colposcopy; D005260:Female; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D011446:Prospective Studies; D065310:Squamous Intraepithelial Lesions of the Cervix / Q000473:pathology* / Q000601:surgery*; D002583:Uterine Cervical Neoplasms / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000473:pathology
Atypical squamous cells of undetermined significance; Cervical intraepithelial neoplasia; High-grade squamous intraepithelial lesion; Loop electrosurgical excision procedure