The Role of ARV Associated Adverse Drug Reactions in Influencing Adherence Among HIV-Infected Individuals: A Systematic Review and Qualitative Meta-Synthesis.
Poor adherence remains a major barrier to achieving the clinical and public health benefits of antiretroviral drugs (ARVs). A systematic review and qualitative meta-synthesis was conduct to evaluate how ARV adverse drug reactions may influence ARV adherence. Thirty-nine articles were identified, and 33 reported that ARV adverse drug reactions decreased adherence and six studies found no influence. Visually noticeable adverse drug reactions and psychological adverse reactions were reported as more likely to cause non-adherence compared to other adverse drug reactions. Six studies reported a range of adverse reactions associated with EFV-containing regimens contributing to decreased adherence. Informing HIV-infected individuals about ARV adverse drug reactions prior to initiation, counselling about coping mechanisms, and experiencing the effectiveness of ARVs on wellbeing may improve ARV adherence.
School of Public Health, Shandong University, Jinan, China. hcli@alumni.cuhk.net.|UNC Project-China, Institute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. hcli@alumni.cuhk.net.
Haochu
H
Li
School of Public Health, Shandong University, Jinan, China.
Gifty
G
Marley
School of Public Health, Shandong University, Jinan, China.
Wei
W
Ma
Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Chongyi
C
Wei
UNC Project-China, Institute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Mellanye
M
Lackey
UNC Project-China, Institute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Qingyan
Q
Ma
HIV Department, World Health Organization, Geneva, Switzerland.
Françoise
F
Renaud
HIV Department, World Health Organization, Geneva, Switzerland.
Marco
M
Vitoria
HIV Department, World Health Organization, Geneva, Switzerland.
Rachel
R
Beanland
HIV Department, World Health Organization, Geneva, Switzerland.
Meg
M
Doherty
UNC Project-China, Institute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. jdtucker@med.unc.edu.|UNC Project-China, Guangdong Provincial Skin Diseases and STI Control, Number 2 Lujing Road, Guangzhou, 510095, China. jdtucker@med.unc.edu.
Joseph D
JD
Tucker
D000223:Adaptation, Psychological; D000480:Alkynes; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D048588:Benzoxazines / Q000009:adverse effects / Q000627:therapeutic use; D003376:Counseling; D003521:Cyclopropanes; D064420:Drug-Related Side Effects and Adverse Reactions / Q000209:etiology* / Q000523:psychology; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D055118:Medication Adherence; D036301:Qualitative Research
D000480:Alkynes; D019380:Anti-HIV Agents; D048588:Benzoxazines; D003521:Cyclopropanes; C098320:efavirenz
Adherence; Adverse drug reaction; Antiretroviral; HIV; Qualitative meta-synthesis