Prenatal exposure to perfluoroalkyl substances and anogenital distance at 3 months of age in a Danish mother-child cohort.
In the Odense child cohort, serum concentrations of perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) were measured in 638 pregnant women. Birth weight, head and abdominal circumferences and gestational age were determined. Anogenital distance (AGD), the distance from the anus to the genital organs, and penile width were measured 3 months after expected date of birth in 511 children. PFOS, PFHxS, PFNA and PFDA were associated with a decreased AGD in girls (p-trend<0.05) after adjusting for age and weight-for-age standard deviation score. PFOS in the highest quartile was associated with a 2.8mm (95% confidence intervals -4.5; -1.1) reduction in AGD in girls. No such tendencies were seen in boys. However, a tendency toward increased birth weight in girls and reduced birth weight in boys suggests that sex-dimorphic effects may occur from endocrine disrupting effects of these substances.
Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark.
Dorte Vesterholm
DV
Lind
Rigshospitalet, Copenhagen University Hospital, Department of Growth and Reproduction, Blegdamsvej 9, 2100 Copenhagen, Denmark.
Lærke
L
Priskorn
Rigshospitalet, Copenhagen University Hospital, Department of Growth and Reproduction, Blegdamsvej 9, 2100 Copenhagen, Denmark.
Tina Harmer
TH
Lassen
Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark.
Flemming
F
Nielsen
Odense University Hospital, Hans Christian Andersen Children's Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark; Odense Patient data Exploratory Network (OPEN), University of Southern Denmark, Odense, Denmark.
Henriette Boye
HB
Kyhl
Laboratory of Genomic and Molecular Biomedicine, Department of Biology, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen, Denmark.
David Møbjerg
DM
Kristensen
Odense University Hospital, Hans Christian Andersen Children's Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark; Odense University Hospital, Institute for Clinical Research, Sdr. Boulevard 29, 5000 Odense C, Denmark.
Henrik Thybo
HT
Christesen
Odense University Hospital, Department of Obstetrics and Gynaecology, Sdr. Boulevard 29, 5000 Odense C, Denmark; Odense University Hospital, Institute for Clinical Research, Sdr. Boulevard 29, 5000 Odense C, Denmark.
Jan Steener
JS
Jørgensen
Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark; Department of Environmental Health, Harvard T.H.Chan School of Public Health, Boston, MA 02215, USA.
Philippe
P
Grandjean
Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark; Odense University Hospital, Hans Christian Andersen Children's Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark; Odense Patient data Exploratory Network (OPEN), University of Southern Denmark, Odense, Denmark. Electronic address: tkjensen@health.sdu.dk.
Tina Kold
TK
Jensen
D000328:Adult; D017738:Alkanesulfonic Acids / Q000097:blood* / Q000633:toxicity; D001003:Anal Canal / Q000033:anatomy & histology; D000886:Anthropometry; D015331:Cohort Studies; D003718:Denmark / Q000453:epidemiology; D005260:Female; D005466:Fluorocarbons / Q000097:blood* / Q000633:toxicity; D005836:Genitalia, Female / Q000033:anatomy & histology; D005837:Genitalia, Male / Q000033:anatomy & histology; D006801:Humans; D007223:Infant; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology* / Q000503:physiopathology; D011446:Prospective Studies; D012737:Sex Factors
D017738:Alkanesulfonic Acids; D005466:Fluorocarbons
Anogenital distance; Birth weight; Endocrine disruption; Gestational length; Perfluorinated compounds; Reproduction