Direct synthesis of sulfonated dihydroisoquinolinones from N-allylbenzamide and arylsulfinic acids via TBHP-promoted cascade radical addition and cyclization.
A novel synthesis of sulfonated dihydroisoquinolinones via cascade radical addition and cyclization was developed in the presence of tert-butyl hydroperoxide (TBHP). The reactions generated the desired sulfonated dihydroisoquinolinones in good yields from readily available arylsulfinic acids and N-allylbenzamides under metal-free conditions.
Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, P. R. China. leiwang@chnu.edu.cn taomiaochem@163.com.
Dong
D
Xia
Yang
Y
Li
Tao
T
Miao
Pinhua
P
Li
Lei
L
Wang