A Nucleoporin at the Meiotic Kinetochore.
In this issue of Developmental Cell, Hattersley et al. (2016) use the unique biology of meiosis I, in which the cell can exit the division without reforming the nuclear envelope, to uncover an intriguing role of the nucleoporin MEL-28 in mediating chromosome segregation via its interaction with PP1 at the kinetochore.
Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
Amanda M
AM
Bonner
Stowers Institute for Medical Research, Kansas City, MO 64110, USA; Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA. Electronic address: rsh@stowers.org.
R Scott
RS
Hawley
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism*; D020090:Chromosome Segregation / Q000235:genetics; D004268:DNA-Binding Proteins; D006801:Humans; D018386:Kinetochores / Q000378:metabolism; D008540:Meiosis / Q000235:genetics*; D009685:Nuclear Envelope / Q000235:genetics / Q000378:metabolism*; D028861:Nuclear Pore Complex Proteins / Q000235:genetics / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D060066:Protein Interaction Maps / Q000235:genetics; D017476:Receptors, Neuropeptide Y / Q000235:genetics / Q000378:metabolism*
D029742:Caenorhabditis elegans Proteins; D004268:DNA-Binding Proteins; D028861:Nuclear Pore Complex Proteins; D009687:Nuclear Proteins; D017476:Receptors, Neuropeptide Y; C514979:mel-28 protein, C elegans; C109491:neuropeptide Y4 receptor