Gelatin-carboxymethyl tamarind gum biocomposites: In vitro characterization & anti-inflammatory pharmacodynamics.
In this study, gelatin and carboxymethyl tamarind gum (CTG) were chemically cross-linked to control the delivery of aceclofenac from their interpenetrating network (IPNs). Infrared spectra, thermal and X-ray data supported that drug and polymer was compatible in the composite hydrogels. Irregularly shaped IPN microstructures were seen under field emission scanning electron microscope (FE-SEM). IPN system was capable of entrapping about 96% of the drug fed. CTG in IPN structures suppressed the drug release rate in HCl solution (pH1.2); however extended the same in phosphate buffer solution (pH6.8). The drug release was controlled by polymer chain relaxation/swelling and simple diffusion in vitro. The anti-inflammatory activity of drug-loaded biocomposites lasted over 7h in albino rats, thus suggesting their potential as an anti-inflammatory therapeutics.
Department of Pharmaceutics, Gupta College of Technological Sciences, Ashram More, G.T. Road, Asansol 713301, West Bengal, India. Electronic address: janapharmacy@rediffmail.com.
Sougata
S
Jana
Department of Pharmaceutics, Gupta College of Technological Sciences, Ashram More, G.T. Road, Asansol 713301, West Bengal, India.
Abhisek
A
Banerjee
Department of Pharmaceutics, Gupta College of Technological Sciences, Ashram More, G.T. Road, Asansol 713301, West Bengal, India.
Kalyan Kumar
KK
Sen
Department of Pharmaceutics, Gupta College of Technological Sciences, Ashram More, G.T. Road, Asansol 713301, West Bengal, India.
Sabyasachi
S
Maiti
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism; D002152:Calorimetry, Differential Scanning; D004008:Diclofenac / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D004195:Disease Models, Animal; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D005780:Gelatin / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry; D008297:Male; D008855:Microscopy, Electron, Scanning; D011134:Polysaccharides / Q000737:chemistry*; D051381:Rats; D017550:Spectroscopy, Fourier Transform Infrared; D029861:Tamarindus / Q000378:metabolism*
D000893:Anti-Inflammatory Agents; D004337:Drug Carriers; D020100:Hydrogels; D011134:Polysaccharides; D004008:Diclofenac; D005780:Gelatin; C056498:aceclofenac
Anti-inflammatory activity; Biocomposites; Gelatin; Interpenetrating network; Tamarind polysaccharide