Powering Tumor Metastasis with Recycled Fuel.
Receptor tyrosine kinase (RTK) recycling is of critical importance for RTK signaling and cancer, yet the process is poorly understood. In this issue, Ye et al. identify GOLM1 as a cargo adaptor that drives hepatocellular carcinoma metastasis by promoting EGFR recycling and provide insights into how this process is regulated.
Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University, Taichung 404, Taiwan. Electronic address: mhung@mdanderson.org.
Mien-Chie
MC
Hung
Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Riyao
R
Yang
Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Yutong
Y
Sun
D006528:Carcinoma, Hepatocellular; D066246:ErbB Receptors; D006801:Humans; D008113:Liver Neoplasms; D020794:Receptor Protein-Tyrosine Kinases; D015398:Signal Transduction
D066246:ErbB Receptors; D020794:Receptor Protein-Tyrosine Kinases