The influence of caregivers and behavioral and psychological symptoms on nursing home placement of persons with Alzheimer's disease: A matched case-control study.
OBJECTIVE
Behavioral and psychological symptoms of dementia in individuals with Alzheimer's disease and caregiver characteristics may influence the decision to provide care at home or in a nursing home, though few studies examine this association near the actual time of nursing home placement. Using a matched case-control design, this study investigates the association between (1) total Neuropsychiatric Inventory score, (2) the Neuropsychiatric Inventory-4 (an agitation/aggression subscale), and (3) individual domains of the Neuropsychiatric Inventory and nursing home placement.


METHODS
Data from the South Carolina Alzheimer's disease Registry provides an opportunity to expand the literature by looking at cases at the time of nursing home care eligibility/placement and allowing for propensity-score-matched controls. Cases (n = 352) entered a nursing home within 6 months of study initiation; controls (n = 289) remained in the community. Registry data were combined with caregiver survey data, including the Neuropsychiatric Inventory. Conditional logistic regression was applied.


RESULTS
A 10% increase in the Neuropsychiatric Inventory score implied a 30% increase in odds of nursing home admission (odds ratio: 1.30; 95% confidence interval: 1.14-1.50), having married or male caregivers predicted nursing home placement. Cases versus controls were significantly more likely to have behavioral and psychological symptoms of dementia related to agitation/aggression 1 month prior to nursing home admission.


CONCLUSIONS
Interventions targeting behavioral and psychological symptoms of dementia without available effective interventions in individuals with Alzheimer's disease and caregiver support services are necessary to prevent or delay nursing home admission.
Quintiles, Overland Park, KS, USA.
Candace N
CN
Porter
Office for the Study of Aging, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Margaret C
MC
Miller
Office for the Study of Aging, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Marcia
M
Lane
Office for the Study of Aging, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Carol
C
Cornman
Department of Epidemiology, Genentech Incorporated, San Francisco, CA, USA.
Khaled
K
Sarsour
Global Patient Outcomes & Real World Evidence, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA.
Kristin
K
Kahle-Wrobleski
Dementia; Neuropsychiatric Inventory; conditional logistic regression; long-term care; propensity score matching