Urethral strictures after radiation therapy for prostate cancer.
Urethral stricture after radiation therapy for localized prostate cancer is a delicate problem as the decreased availability of tissue healing and the close relation to the sphincter complicates any surgical approach. We here review the pathophysiology, dosimetry, and the disease specific aspects of urethral strictures after radiotherapy. Moreover we discuss different treatment option such as direct vision internal urethrotomy as well as techniques for open reconstruction with and without tissue transfer.
Department of Urology, Inselspital Bern, Bern, Switzerland.
Felix
F
Moltzahn
Department of Radiation-Oncology, Inselspital Bern, Bern, Switzerland.
Alan
A
Dal Pra
Department of Urology, Inselspital Bern, Bern, Switzerland.
Marc
M
Furrer
Department of Urology, Inselspital Bern, Bern, Switzerland.
George
G
Thalmann
Department of Urology, Inselspital Bern, Bern, Switzerland.
Martin
M
Spahn
D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D014525:Urethral Stricture / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery
Prostate neoplasms; Radiation; Urethral stricture