Diagnostic accuracy and clinical utility of a new noninvasive index for hepatic steatosis in patients with hepatitis B virus infection.
The aim of the present study was to construct a cost-effective noninvasive diagnostic index for prediction of hepatic steatosis in patients with hepatitis B virus(HBV) infection. From January 2011 to January 2015, a total of 364 consecutive subjects who underwent liver biopsies were enrolled. The Receiver-operating characteristic(ROC) curves and Obuchowski measure were constructed to evaluate the diagnostic accuracy of the new index. The AUROCs of steatosis index of patients with HBV infection (SIHBV) in predicting of steatosis were 0.929 (95% confidence interval:0.889-0.970, P < 0.05) in the model group and 0.855 (0.794-0.917, P < 0.05) in the validation group respectively. Comparisons of AUROCs demonstrated that SIHBV was significantly superior to Korean Score, fatty liver index (FLI), hepatic steatosis index (HSI), lipid accumulation product(LAP), and fatty liver disease (FLD) index for prediction of hepatic steatosis in model group and validation group(all P < 0.01). Especially for patients with hepatic steatosis percentage of 5.0-9.9% and 10.0-19.9%, SIHBV had a sensitivity of 63.6% and 79.2%, whereas it were 29.1% and 45.8% for Ultrasonography (all P < 0.05). In conclusion, as a cost-effective, simple, noninvasive, and readily available method, SIHBV may act as a massive screening tool before further examinations such as MRI, CT, transient elastography, or liver biopsy, especially for developing countries.
Department of Infectious Diseases,The First People's Hospital of Shunde, Shunde, Guangdong, China.
Zhiqiao
Z
Zhang
Department of Infectious Diseases,The First People's Hospital of Shunde, Shunde, Guangdong, China.
Gongsui
G
Wang
Department of Pathology, The First People's Hospital of Shunde, Shunde, Guangdong, China.
Kaifu
K
Kang
Department of Pathology, The First People's Hospital of Shunde, Shunde, Guangdong, China.
Guobiao
G
Wu
Department of Infectious Diseases,The First People's Hospital of Shunde, Shunde, Guangdong, China.
Peng
P
Wang
D000328:Adult; D005234:Fatty Liver / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000821:virology; D005260:Female; D006509:Hepatitis B / Q000150:complications* / Q000821:virology; D006515:Hepatitis B virus; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D012372:ROC Curve; D012189:Retrospective Studies; D012720:Severity of Illness Index; D014463:Ultrasonography