Ductal Spread Versus High-Grade Prostatic Intraepithelial Neoplasia: A Diagnostic Pitfall.
Ductal spread (DS) of acinar adenocarcinoma of the prostate can lead to an incomplete replacement of the benign epithelium by cancer cells, resulting in a lesion that can be indistinguishable from high-grade prostatic intraepithelial neoplasia (HGPIN). Kovi and colleagues demonstrated 30 years ago that there is a significant association between the presence of DS and local extent of invasive adenocarcinoma, making the distinction between DS and HGPIN clinically relevant. However, despite the existence of certain morphologic features that are suggestive of DS, a definitive differentiation between the aforementioned lesions cannot always be attained.
University of Illinois at Chicago, IL, USA amacosta@uic.edu.
Andres M
AM
Acosta
University of Illinois at Chicago, IL, USA.
Asma
A
Sharif
University of Illinois at Chicago, IL, USA.
John V
JV
Groth
University of Illinois at Chicago, IL, USA.
Andre
A
Kajdacsy-Balla
D018267:Carcinoma, Acinar Cell / Q000175:diagnosis* / Q000473:pathology; D044584:Carcinoma, Ductal / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008297:Male; D060787:Neoplasm Grading; D019048:Prostatic Intraepithelial Neoplasia / Q000175:diagnosis* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology
acinar adenocarcinoma; ductal spread; high-grade prostatic intraepithelial neoplasia; intraductal carcinoma; prostate