[Antibacterial and antifungal activity of Salvia apiana against clinically important microorganisms].
Due to the great global concern regarding bacterial resistance to antibiotics, an ongoing search for new molecules having antibacterial activity is necessary. This study evaluated the antibacterial and anticandidal effects of a hexane extract from the root of Salvia apiana. Salvia extracts at concentrations of 27, 13.5, 6.8 and 3.4mg/ml caused growth inhibition of Staphylococcus aureus, Streptococcus pyogenes, Enterococcus faecalis and Candida albicans. However, no significant effect was observed on Escherichia coli and Candida tropicalis in comparison to vehicle. It was here demonstrated for the first time that Salvia apiana has an important antimicrobial effect on human pathogens of great clinical value, thus opening the field to continue the evaluation of this lamiaceous plant for its future use as a therapeutic agent.
Facultad de Ciencias Químicas e Ingeniería, Universidad Autónoma de Baja California, Tijuana, B.C., México.
Iván
I
Córdova-Guerrero
Departamento de Farmacología, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, S.L.P., México.
Othoniel H
OH
Aragon-Martinez
Facultad de Ciencias Químicas e Ingeniería, Universidad Autónoma de Baja California, Tijuana, B.C., México.
Laura
L
Díaz-Rubio
Laboratorio de Microbiología, Facultad de Odontología, Universidad Autónoma de Baja California, Mexicali, B.C., México.
Santiago
S
Franco-Cabrera
Laboratorio de Microbiología, Facultad de Odontología, Universidad Autónoma de Baja California, Mexicali, B.C., México.
Nicolas A
NA
Serafín-Higuera
Laboratorio de Ciencias Básicas, Facultad de Estomatología, Universidad Autónoma de San Luis Potosí, S.L.P., México.
Amaury
A
Pozos-Guillén
Departamento de Farmacología, Facultad de Odontología, Universidad Autónoma de Baja California, Mexicali, B.C., México.
Tely A
TA
Soto-Castro
Departamento de Farmacología, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, S.L.P., México.
Flavio
F
Martinez-Morales
Departamento de Farmacología, Facultad de Odontología, Universidad Autónoma de Baja California, Mexicali, B.C., México. Electronic address: mario.isiordia@uabc.edu.mx.
Mario
M
Isiordia-Espinoza
D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D052978:Disk Diffusion Antimicrobial Tests; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006586:Hexanes; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D027544:Salvia / Q000737:chemistry*; D012997:Solvents; D013045:Species Specificity
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D006586:Hexanes; D010936:Plant Extracts; D012997:Solvents; C026385:n-hexane
Bacterias gram negativas; Bacterias gram positivas; Gram-negative bacteria; Gram-positive bacteria; Levaduras; Salvia apiana; Yeast