Sympathetic activity and early mobilization in patients in intensive and intermediate care with severe brain injuries: a preliminary prospective randomized study.
BACKGROUND
Patients who experience severe brain injuries are at risk of secondary brain damage, because of delayed vasospasm and edema. Traditionally, many of these patients are kept on prolonged bed rest in order to maintain adequate cerebral blood flow, especially in the case of subarachnoid hemorrhage. On the other hand, prolonged bed rest carries important morbidity. There may be a clinical benefit in early mobilization and our hypothesis is that early gradual mobilization is safe in these patients. The aim of this study was to observe and quantify the changes in sympathetic activity, mainly related to stress, and blood pressure in gradual postural changes by the verticalization robot (Erigo®) and after training by a lower body ergometer (MOTOmed-letto®), after prolonged bed rest of minimum 7 days.


METHODS
Thirty patients with severe neurological injuries were randomized into 3 groups with different protocols of mobilization: Standard, MOTOmed-letto® or Erigo® protocol. We measured plasma catecholamines, metanephrines and blood pressure before, during and after mobilization.


RESULTS
Blood pressure does not show any significant difference between the 3 groups. The analysis of the catecholamines suggests a significant increase in catecholamine production during Standard mobilization with physiotherapists and with MOTOmed-letto® and no changes with Erigo®.


CONCLUSIONS
This preliminary prospective randomized study shows that the mobilization of patients with severe brain injuries by means of Erigo® does not increase the production of catecholamines. It means that Erigo® is a well-tolerated method of mobilization and can be considered a safe system of early mobilization of these patients. Further studies are required to validate our conclusions.


BACKGROUND
The study was registered in the ISRCTN registry with the trial registration number ISRCTN56402432 . Date of registration: 08.03.2016. Retrospectively registered.
Department of Clinical Neurosciences, Neurosurgery Unit, University Hospital CHUV, Rue du Bugnon 46, 1011, Lausanne, Switzerland. alda.a.rocca@gmail.com.
A
A
Rocca
Department of Clinical Neurosciences, Acute Neurorehabilitation Unit, University Hospital CHUV, Lausanne, Switzerland.
J-M
JM
Pignat
Department of Clinical Neurosciences, Acute Neurorehabilitation Unit, University Hospital CHUV, Lausanne, Switzerland.
L
L
Berney
Department of Clinical Neurosciences, Acute Neurorehabilitation Unit, University Hospital CHUV, Lausanne, Switzerland.
J
J
Jöhr
Ecole Polytechnique de Lausanne (EPFL), Lausanne, Switzerland.
D
D
Van de Ville
Department of Clinical Neurosciences, Neurosurgery Unit, University Hospital CHUV, Rue du Bugnon 46, 1011, Lausanne, Switzerland.
R T
RT
Daniel
Department of Clinical Neurosciences, Neurosurgery Unit, University Hospital CHUV, Rue du Bugnon 46, 1011, Lausanne, Switzerland.
M
M
Levivier
Department of Clinical Neurosciences, Neurology Unit, University Hospital CHUV, Lausanne, Switzerland.
L
L
Hirt
Division of Vascular Neurology and Rehabilitation, Department of Neurology, University Hospital Zürich, Zürich, Switzerland.
A R
AR
Luft
Biomedicine Departement, University Hospital CHUV, Lausanne, Switzerland.
E
E
Grouzmann
Department of Clinical Neurosciences, Acute Neurorehabilitation Unit, University Hospital CHUV, Lausanne, Switzerland.
K
K
Diserens
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000502:physiology*; D001930:Brain Injuries / Q000503:physiopathology* / Q000534:rehabilitation*; D002395:Catecholamines / Q000097:blood*; D004434:Early Ambulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D026741:Physical Therapy Modalities; D055815:Young Adult
D002395:Catecholamines
Brain injuries; Catecholamines; Mobilization; Neurovegetative disorders; Robotic; Subarachnoid hemorrhage