Surface engineering of SPIONs: role of phosphonate ligand multivalency in tailoring their efficacy.
We report the design of scaffolds containing mono-, bis-, and tris-phosphonate coordinating groups, and a polyethylene glycol chain, for stabilizing superparamagnetic iron oxide nanoparticles (SPIONs), using simple and versatile chemistry. We demonstrate that the number of anchoring phosphonate sites on the ligand influence the colloidal stability, magnetic and biological properties of SPIONs, and the latter do not solely depend on attaching moieties that can enhance their aqueous dispersion. These parameters can be tailored by the number of conjugation sites on the ligand, as evidenced from dynamic light scattering at various salt concentrations, magnetic relaxivities and cell viability studies.
Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, Quebec H3A 0B8, Canada.
Tina
T
Lam
Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, Quebec H3A 0B8, Canada.|Department of Electrical Engineering, Ecole Polytechnique de Montreal, C.P. 6079 succ. Centre-Ville, Montreal, Quebec H3C 3A7, Canada.|Research Centre, Montreal Heart Institute, 5000 Belanger Street, Montreal, Quebec H1T 1C8, Canada.
Pramod K
PK
Avti
Department of Electrical Engineering, Ecole Polytechnique de Montreal, C.P. 6079 succ. Centre-Ville, Montreal, Quebec H3C 3A7, Canada.
Philippe
P
Pouliot
Research Centre, Montreal Heart Institute, 5000 Belanger Street, Montreal, Quebec H1T 1C8, Canada.|Department of Medicine, Universite de Montreal, Montreal, Quebec, Canada.
Jean-Claude
JC
Tardif
Research Centre, Montreal Heart Institute, 5000 Belanger Street, Montreal, Quebec H1T 1C8, Canada.|Department of Medicine, Universite de Montreal, Montreal, Quebec, Canada.
Éric
É
Rhéaume
Department of Electrical Engineering, Ecole Polytechnique de Montreal, C.P. 6079 succ. Centre-Ville, Montreal, Quebec H3C 3A7, Canada.|Research Centre, Montreal Heart Institute, 5000 Belanger Street, Montreal, Quebec H1T 1C8, Canada.
Frederic
F
Lesage
Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, Quebec H3A 0B8, Canada.
Ashok
A
Kakkar