Transcranial doppler re-screening of subjects who participated in STOP and STOP II.
In children with Sickle Cell Disease, the combination of risk stratification with Transcranial Doppler Ultrasound (TCD) and selective chronic red cell transfusion (CRCT-the STOP Protocol) is one of the most effective stroke prevention strategies in medicine. How fully it is being implemented is unclear. Nineteen of 26 sites that conducted the two pivotal clinical trials (STOP and STOP II) participated in Post STOP, a comprehensive medical records review assessing protocol implementation in the 10-15 years since the trials ended. Professional abstractors identified medical records in the Post STOP era in 2851 (74%) of the 3,840 children who took part in STOP and/or STOP II, and documented TCD rescreening, maintenance of CRCT in those at risk, and stroke. Among 1,896 children eligible for TCD rescreening (target group), evidence of any rescreening was found in 1,090 (57%). There was wide site variation in TCD rescreening ranging from 18% to 91% of eligible children. Both younger age and having a conditional TCD during STOP/II were associated with a higher likelihood of having a TCD in Post STOP. Sixty eight new abnormal, high risk cases were identified. Despite clear evidence of benefit the STOP protocol is not fully implemented even at experienced sites. Site variation suggests that system improvements might remove barriers to implementation and result in even greater reduction of ischemic stroke in children with SCD. Am. J. Hematol. 91:1191-1194, 2016. © 2016 Wiley Periodicals, Inc.
Neurology, Medical University of South Carolina, Charleston, South Carolina.
Robert J
RJ
Adams
Neurology, Medical University of South Carolina, Charleston, South Carolina.
Dan T
DT
Lackland
Tidelands Health Cancer Service, Georgetown, SC.
Lynette
L
Brown
Neurology, Medical University of South Carolina, Charleston, South Carolina.
David
D
Brown
Neurology, Medical University of South Carolina, Charleston, South Carolina.
Jenifer
J
Voeks
University of California San Francisco, San Francisco, California.
Heather J
HJ
Fullerton
Pediatrics, Medical University of South Carolina, Charleston, South Carolina.
Julie
J
Kanter
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Janet L
JL
Kwiatkowski
D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications / Q000000981:diagnostic imaging; D001783:Blood Flow Velocity; D002648:Child; D002675:Child, Preschool; D017707:Erythrocyte Transfusion; D019983:Guideline Adherence; D006801:Humans; D008403:Mass Screening / Q000379:methods; D018570:Risk Assessment; D020521:Stroke / Q000000981:diagnostic imaging / Q000517:prevention & control*; D017585:Ultrasonography, Doppler, Transcranial / Q000379:methods*