Fasting glycemia at the first prenatal visit and pregnancy outcomes in Russian women.
BACKGROUND
The aim of this study was to evaluate the associations between fasting glycemia (FG) at the first prenatal visit and adverse pregnancy outcomes.


METHODS
Medical records of 1584 pregnant women with a recorded level of FG <7 mmol/L before 24 weeks of gestation and delivery after 24 weeks were examined 823 of them underwent oral glucose tolerance test (OGTT) at 24-32 weeks of pregnancy. FG values were devided into five groups starting with <4.1 mmol/L as the first group, with subsequent increases of 0.5 mmol/L between groups and >5.6 mmol/L as the last group. The main outcomes were gestational diabetes mellitus (GDM) development, macrosomia, primary cesarean delivery, shoulder dystocia or birth injury.


RESULTS
With increasing FG levels at first prenatal visit, the frequency of GDM (among women who underwent OGTT) increased from 18.3% in the lowest category to 44.4% in the highest (odds ratio (OR) 2.94; 95% confidence interval [CI]: 1.39-6.19) and the frequency of hyperbilirubinemia increased from 4.5 to 18% respectively (OR 4.7; 95% CI: 1.8-12.5). After adjustment for maternal age and BMI, only the highest glucose category (5.6<FG<7 mmol/L) was significantly associated with the increased risk of the above mentioned outcomes. The frequency of shoulder dystocia/birth injury (OR 24.5; 95% CI: 2.8-214.8) and preeclampsia (OR 2.7; 95% CI: 1.2-5.9) was increased in the highest glucose category compared to the intermediary categories.


CONCLUSIONS
Only the highest glucose category (5.6<FG<7 mmol/L) at the first prenatal visit was strongly associated with some adverse pregnancy outcomes.
Institute of Endocrinology, Almazov Federal North-West Medical Research Centre, Saint Petersburg, Russia - pvpopova@yandex.ru.
Polina
P
Popova
Alexandra
A
Tkachuk
Alexandra
A
Dronova
Andrey
A
Gerasimov
Ekaterina
E
Kravchuk
Maria
M
Bolshakova
Olga
O
Rozdestvenskaya
Ksenia
K
Demidova
Alla
A
Nikolaeva
Elena
E
Grineva
D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D015992:Body Mass Index; D005215:Fasting; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D012189:Retrospective Studies; D012426:Russia / Q000453:epidemiology
D001786:Blood Glucose