Evolution of the Management of Resectable Pancreatic Cancer.
In pancreatic cancer, as with many other solid tumors, a commonly held surgical adage-a chance to cut is a chance to cure-has been promulgated throughout the years. Following such reasoning, surgical extirpation of a localized tumor would prevent tumor dissemination and metastatic tumor progression. However, decades of surgical experience have demonstrated that surgical resection alone provides a limited median survival benefit. Despite the optimization of surgical technique and perioperative management over the past three decades, little progress has been made to improve the limited survival of patients with localized pancreatic cancer who receive surgery. In this article, we discuss the rationale for a novel management strategy for patients with resectable pancreatic cancer, which may improve patient selection and the delivery of multimodality therapy.
Medical College of Wisconsin, Milwaukee, WI stsai@mcw.edu.
Susan
S
Tsai
Medical College of Wisconsin, Milwaukee, WI.
Beth A
BA
Erickson
Medical College of Wisconsin, Milwaukee, WI.
Kulwinder
K
Dua
Medical College of Wisconsin, Milwaukee, WI.
Paul S
PS
Ritch
Medical College of Wisconsin, Milwaukee, WI.
Parag
P
Tolat
Medical College of Wisconsin, Milwaukee, WI.
Douglas B
DB
Evans
D006801:Humans; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome