In vivo tissue-tropism of adeno-associated viral vectors.
In this review, a brief account of the historical perspective of the discovery of the first cellular receptor and co-receptor of the prototype adeno-associated virus serotype 2 (AAV2) will be presented. The Subsequent discovery of a number of AAV serotypes, and attempts to identify the cellular receptors and co-receptors for these serotype vectors has had significant implications in their use in human gene therapy. As additional AAV serotypes are discovered and isolated, a detailed understanding of their tropism is certainly likely to play a key role in all future studies, both basic science as well as clinical.
Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida College of Medicine, 2033 Mowry Road, Gainesville, FL 32611, United States; Department of Molecular Genetics & Microbiology, Powell Gene Therapy Center, University of Florida College of Medicine, 2033 Mowry Road, Gainesville, FL 32611, United States. Electronic address: aruns@peds.ufl.edu.
Arun
A
Srivastava
D000229:Dependovirus / Q000235:genetics / Q000502:physiology*; D005822:Genetic Vectors; D006801:Humans; D011991:Receptors, Virus / Q000378:metabolism; D056189:Viral Tropism; D053585:Virus Attachment; D053586:Virus Internalization
D011991:Receptors, Virus