Effects of short-term supplementation with bovine lactoferrin and/or immunoglobulins on body mass and metabolic measures: a randomised controlled trial.
Given the role of the intestinal microbiota in obesity and related disease, strategies to modulate the composition of the intestinal microbiota may augment traditional weight-management approaches. Here, we examined the safety and tolerability of 28 days of supplementation with bovine whey-derived lactoferrin and immunoglobulin supplements in a cross-sectional cohort of free-living adults. Participants (n = 20 each group) received enteric-coated whey-derived bovine lactoferrin (200 mg), immunoglobulin (200 mg or 800 mg), combination lactoferrin/immunoglobuiln supplements (200 mg/200 mg, 200 mg/800 mg) or placebo in a double-blind design. Supplement use was generally well tolerated and routine haematology, and clinical chemistry measures were largely unchanged following supplementation. Measures of body composition remained stable and indices of glycaemic control and blood lipids revealed fluctuations of <5% but were not significantly different between groups. Overall, short-term lactoferrin/immunoglobulin supplementation was well tolerated in this cohort; use of these types of supplements to enhance other weight management strategies should be investigated over extended periods.
a Menzies Health Institute Queensland, Griffith University, QLD , Australia.|b School of Medical Science, Griffith University, QLD , Australia.
Amanda J
AJ
Cox
b School of Medical Science, Griffith University, QLD , Australia.
Annabelle M
AM
Watts
a Menzies Health Institute Queensland, Griffith University, QLD , Australia.
Ping
P
Zhang
a Menzies Health Institute Queensland, Griffith University, QLD , Australia.|c School of Allied Health Sciences, Griffith University, QLD , Australia.
Lauren T
LT
Williams
a Menzies Health Institute Queensland, Griffith University, QLD , Australia.|d School of Medicine, Griffith University, QLD , Australia.
Allan W
AW
Cripps
a Menzies Health Institute Queensland, Griffith University, QLD , Australia.|b School of Medical Science, Griffith University, QLD , Australia.
Nicholas P
NP
West
D000293:Adolescent; D000328:Adult; D001794:Blood Pressure; D001823:Body Composition; D015992:Body Mass Index; D001835:Body Weight; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D019587:Dietary Supplements; D004311:Double-Blind Method; D002149:Energy Intake; D015444:Exercise; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage*; D007781:Lactoferrin / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference; D055815:Young Adult
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D007136:Immunoglobulins; D014280:Triglycerides; D007781:Lactoferrin
Immunoglobulins; lactoferrin; metabolism; obesity; weight management