[Intensity-modulated radiotherapy of head and neck cancers: Dose effects on the ocular, orbital and eyelid structures].
Radiation-induced damage of ocular, orbital and eyelid structures are mainly reported for the optic nerve, retina, lens and lacrimal gland. Dose-volume relationships are, however, inaccurate due to the small volume of most of the organs at risk involved and limited ability of irradiation techniques to spare these structures in the pre-IMRT (intensity-modulated radiation therapy) era. The ability of newest radiation techniques including IMRT and proton therapy to generate steep dose gradients may yield more accurate models in the future. Some toxicities are severe and irreversible, leading to vision loss, as in the case of radiation-induced optic neuropathy for which curative treatments are suboptimal. Other toxicities can lead to reversible vision loss but can be surgically corrected, as is the case for radiation-induced cataract. In this paper, we will review the dose effects for the ocular; orbital and eyelid structures.
Département de radiothérapie, centre Antoine-Lacassagne, 33, avenue Valombrose, 06189 Nice, France. Electronic address: jthariat@gmail.com.
J
J
Thariat
Département de radiothérapie, centre Léon-Bérard, 28, rue Laennec, 69008 Lyon, France.
S
S
Racadot
Clinique Victor-Hugo, institut interrégional de cancérologie centre Jean-Bernard, 9, rue Beauverger, 72000 Le Mans, France.
Y
Y
Pointreau
Département de radiothérapie, institut du cancer de Montpellier, 208, avenue des Apothicaires, parc Euromédecine, 34298 Montpellier cedex 5, France.
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P
Boisselier
Département d'ophtalmologie, hôpital de la Croix-Rousse, 103, boulevard de la Croix-Rousse, 69317 Lyon cedex 04, France.
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JD
Grange
Service de radiothérapie et de curiethérapie, institut universitaire du cancer Toulouse-Oncopôle, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.
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P
Graff
Centre de protonthérapie, institut Paul-Scherrer, WPTA 144, 5232 Villigen PSI, Suisse.
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DC
Weber
D001766:Blindness / Q000209:etiology / Q000517:prevention & control; D002386:Cataract / Q000209:etiology / Q000517:prevention & control; D004307:Dose-Response Relationship, Radiation; D005123:Eye / Q000528:radiation effects*; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D009901:Optic Nerve Diseases / Q000209:etiology / Q000517:prevention & control; D058958:Organs at Risk; D011879:Radiotherapy Dosage; D050397:Radiotherapy, Intensity-Modulated
Eye; Glande lacrymale; Lacrimal gland; Nerf optique; Optic nerve; Orbit; Orbite; Radiation therapy; Radiothérapie; Retina; Rétine; Toxicity; Toxicité; Œil