Relationship between adipokines and lipid profile in postmenopausal women with different apolipoprotein E genotypes.
The aim of the authors of this study was to clarify the relationships among apolipoprotein E (ApoE) genotype, blood pressure, lipid profile, serum leptin, and adiponectin in healthy postmenopausal women. The study was conducted between March 2011 and December 2012 on 266 participants aged 50-65 years from the Institute of Rural Health in Lublin, Poland. Results showed that women had four combinations of genotypes: ɛ2/ɛ3, ɛ3/ɛ3, ɛ3/ɛ4, and ɛ4/ɛ4. Carriers of different genotypes did not differ in terms of age, body mass index (BMI), blood pressure, total cholesterol, high-density lipoprotein (HDL) cholesterol, and adiponectin levels. Mean low-density lipoprotein (LDL) cholesterol levels were higher in ε4 carriers compared to non-carriers. Fasting serum leptin concentrations were higher in homozygotes ɛ4/ɛ4. Leptin correlated positively with BMI in all study groups and with LDL in ɛ2/ɛ3, ɛ3/ɛ3, and ɛ3/ɛ4. Adiponectin correlated negatively with triglycerides in ɛ2/ɛ3, ɛ3/ɛ3, and ɛ3/ɛ4 and positively with HDL in ɛ2/ɛ3 carriers. Adipokines were not associated with blood pressure. Multiple regression analyses demonstrated associations among leptin, ApoE ɛ4/ɛ4, BMI, and LDL, and among adiponectin, BMI, and triglycerides. In healthy postmenopausal women ɛ4/ɛ4 genotype was associated with lower leptin levels. Homozygosity ɛ4/ɛ4 was associated with a more atherogenic lipid profile and possibly dysregulation of leptin and adiponectin signaling in lipid metabolism.
a Department of Physiology , Poznan University of Medical Sciences , Poznan , Poland.
Magdalena
M
Gibas-Dorna
a Department of Physiology , Poznan University of Medical Sciences , Poznan , Poland.
Jacek
J
Piątek
a Department of Physiology , Poznan University of Medical Sciences , Poznan , Poland.
Justyna
J
Kupsz
b Department of Hygiene , Poznan University of Medical Sciences , Poznan , Poland.
Malgorzata
M
Bernatek
a Department of Physiology , Poznan University of Medical Sciences , Poznan , Poland.
Hanna
H
Krauss
c Department of Informatics and Statistics , Poznan University of Medical Sciences , Poznan , Poland.
Anna
A
Sowińska
d Department of Animal Physiology and Biochemistry , University of Life Sciences in Poznan , Poznan , Poland.
Paweł
P
Kołodziejski
e Center for Public Health and Health Promotion , Institute of Rural Health in Lublin , Lublin , Poland.
Alfred
A
Owoc
f Department of Women's Health , Institute of Rural Health in Lublin , Lublin , Poland.
Iwona
I
Bojar
D052242:Adiponectin / Q000097:blood*; D000367:Age Factors; D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics*; D001794:Blood Pressure; D002784:Cholesterol / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005838:Genotype; D006801:Humans; D020738:Leptin / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008875:Middle Aged; D060885:Multiplex Polymerase Chain Reaction; D011044:Poland; D020641:Polymorphism, Single Nucleotide; D017698:Postmenopause / Q000097:blood*
D052242:Adiponectin; D001057:Apolipoproteins E; D020738:Leptin; D008055:Lipids; D002784:Cholesterol
Adiponectin; apolipoprotein E (ApoE) polymorphism; leptin; menopause