Functional diversity of long non-coding RNAs in immune regulation.
Precise and dynamic regulation of gene expression is a key feature of immunity. In recent years, rapid advances in transcriptome profiling analysis have led to recognize long non-coding RNAs (lncRNAs) as an additional layer of gene regulation context. In the immune system, lncRNAs are found to be widely expressed in immune cells including monocytes, macrophages, dendritic cells (DCs), neutrophils, T cells and B cells during their development, differentiation and activation. However, the functional importance of immune-related lncRNAs is just emerging to be characterized. In this review, we discuss the up-to-date knowledge of lncRNAs in immune regulation.
Center for Intestinal and Liver Inflammation Research, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611; Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
Hua
H
Geng
Center for Intestinal and Liver Inflammation Research, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611; Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
Xiao-Di
XD
Tan