Preparation, mechanical property and cytocompatibility of freeze-cast porous calcium phosphate ceramics reinforced by phosphate-based glass.
In this study, phosphate-based glass (PG) was used as a sintering aid for freeze-cast porous biphasic calcium phosphate (BCP) ceramic, which was sintered under a lower temperature (1000°C). The phase composition, pore structure, compressive strength, and cytocompatibility of calcium phosphate composite ceramics (PG-BCP) were evaluated. The results indicated that PG additive reacted with calcium phosphate during the sintering process, forming β-Ca2P2O7; the ions of sodium and magnesium from PG partially substituted the calcium sites of β-calcium phosphate in BCP. The PG-BCP showed good cytocompatibility. The pore width of the porous PG-BCP ceramics was around 50μm, regardless of the amount of PG sintering aid. As the content of PG increased from 0wt.% to 15wt.%, the compressive strength of PG-BCP increased from 0.02 MP to 0.28MPa. When the PG additive was 17.5wt.%, the compressive strength of PG-BCP dramatically increased to 5.66MPa. Addition of 15wt.% PG was the critical point for the properties of PG-BCP. PG is considered as an effective sintering aid for freeze-cast porous bioceramics.
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
Yanqiu
Y
Yang
School of Electromechanical Engineering, Guangdong University of Technology, Guangzhou 510006, China. Electronic address: fphe@gdut.edu.cn.
Fupo
F
He
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China; National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China. Electronic address: jdye@scut.edu.cn.
Jiandong
J
Ye
D000818:Animals; D002130:Calcium Phosphates / Q000494:pharmacology*; D002152:Calorimetry, Differential Scanning; D016923:Cell Death / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002516:Ceramics / Q000494:pharmacology*; D019245:Compressive Strength; D005615:Freezing; D055595:Mechanical Phenomena; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects; D016062:Porosity; D051381:Rats; D013696:Temperature; D014961:X-Ray Diffraction
D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate; C023506:Glass ceramics
Bioceramics; Bone repair material; Calcium phosphate; Phosphate-based glass; Porous structure