Fluorine-18 patents (2009-2015). Part 2: new radiochemistry.
Fluorine-18 ((18)F) is one of the most common positron-emitting radionuclides used in the synthesis of positron emission tomography radiotracers due to its ready availability, convenient half-life and outstanding imaging properties. In Part 1 of this review, we presented the first analysis of patents issued for novel radiotracers labeled with fluorine-18. In Part 2, we follow-up with a focus on patents issued for new radiochemistry methodology using fluorine-18 issued between January 2009 and December 2015.
Department of Radiology, University of Michigan Medical School, 1301 Catherine St., Ann Arbor, MI 48109, USA.
Andrew V
AV
Mossine
Department of Radiology, University of Michigan Medical School, 1301 Catherine St., Ann Arbor, MI 48109, USA.
Stephen
S
Thompson
Department of Radiology, University of Michigan Medical School, 1301 Catherine St., Ann Arbor, MI 48109, USA.
Allen F
AF
Brooks
Department of Medicinal Chemistry, University of Michigan, 428 Church St., Ann Arbor, MI 48109, USA.
Alexandra R
AR
Sowa
Department of Medicinal Chemistry, University of Michigan, 428 Church St., Ann Arbor, MI 48109, USA.
Jason M
JM
Miller
Department of Radiology, University of Michigan Medical School, 1301 Catherine St., Ann Arbor, MI 48109, USA.|Department of Medicinal Chemistry, University of Michigan, 428 Church St., Ann Arbor, MI 48109, USA.
Peter Jh
PJ
Scott
D000818:Animals; D005462:Fluorine Radioisotopes / Q000008:administration & dosage; D006801:Humans; D010330:Patents as Topic / Q000331:legislation & jurisprudence*; D049268:Positron-Emission Tomography / Q000639:trends; D011854:Radiochemistry / Q000331:legislation & jurisprudence* / Q000639:trends
D005462:Fluorine Radioisotopes
18F; PET radiotracers; fluorine-18; positron emission tomography; radiochemistry