Chronic Kidney Disease and Lipid Disorders.
BACKGROUND
Chronic kidney disease (CKD) represents a serious public health problem due to the increase in incidence and prevalence of this disease worldwide. Given the significant morbidity and mortality from cardiovascular disease (CVD) in the population of patients with CKD, and the fact that dyslipidemia itself is a risk factor for CVD, increases the importance of lipid metabolism study in patients with CKD.


OBJECTIVE
Evaluate the lipid status of patients with chronic kidney disease.


METHODS
A one-year prospective study included 150 adult patients who were in various stages of chronic renal failure (stage I to IV). Estimate of creatinine clearance was performed using Cockroft-Goult formula. The classification of patients according to stages of chronic renal insufficiency was performed in accordance with the criteria of Kidney Disease Outcomes Quality Initiative (K/DOQI).


RESULTS
Of the total number of patients (N=150) there was 71 males and 79 females. The mean age of patients was 55.43 years. Average values of serum cholesterol were highest in patients with stage II renal disease and the lowest in patients classified as stage IV (5.76±1.60 mmol/L vs. 5.07±1.88 mmol/L). Analysis of the average value of triglycerides in blood show a slight increase through the stages of CKD in a manner that patients classified into stage I have low serum triglyceride levels (1.73±1.17 mmol/L (range 0.61 to 5.5 mmol/L), and patients classified in stage III the highest value 2.13±1.11 mmol/L (range 0.62 to 4.66 mmol/L).


CONCLUSIONS
Average cholesterol levels does not statistically significantly change with progression of chronic renal disease. There is an almost linear increase in average triglyceride levels in chronic renal disease. Triglyceride levels in serum begins to increase in the early stage of chronic renal disease and reach the peak in stage IV.
Clinic of Radiology, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.
Sandra Vegar
SV
Zubovic
Clinic of Radiology, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.
Spomenka
S
Kristic
Clinic of Radiology, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.
Sabina
S
Prevljak
Clinic of Radiology, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.
Irmina Sefic
IS
Pasic
D002318:Cardiovascular Diseases / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D002784:Cholesterol / Q000097:blood*; D003404:Creatinine / Q000097:blood*; D018450:Disease Progression; D050171:Dyslipidemias / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*
D014280:Triglycerides; D002784:Cholesterol; D003404:Creatinine
Chronic kidney disease (CKD); cholesterol; lipid status; triglycerides