Association betweenOPNgenetic variations and nephrolithiasis risk.
Osteopontin (OPN) has an important role in urolithiasis. However, few studies have explored the association betweenOPNgenetic variants and urolithiasis risk. In the present study, three single-nucleotide polymorphisms (SNPs) (rs28357094, rs11439060 and rs11730582) located on the promoter ofOPNwere genotyped in a total of 480 individuals, including 230 nephrolithiasis patients and 250 matched healthy controls, and the associations between these SNPs and nephrolithiasis risk in different genetic models was assessed. No significant differences were identified in the genotype and allele frequencies of OPN rs28357094 or rs11730582 (P=0.805 for rs28357094; P=0.577 for rs11730582, respectively). However, carriers with theOPNrs11439060 insertion (ins) types (ins/deletion and ins/ins) were overrepresented in urolithiasis patients compared with the controls [odds ratio (OR), 1.55; 95% confidence interval (CI), 1.08-2.22]. In the stratified analysis, the increased risk was more evident among younger subjects (adjusted OR, 1.68; 95% CI, 1.01-2.81), females (2.15; 1.14-4.08), overweight subjects (1.80; 1.07-3.05), normotensive subjects (2.48; 1.02-6.00), abnormal blood sugar subjects (1.58; 1.08-2.30), smokers (1.63; 1.02-2.60), and ever-drinkers (1.98; 1.10-3.60).. These findings revealed that theOPNrs11439060 polymorphism may act as genetic biomarker for the detection of high-risk nephrolithiasis patients.
Department of Urology, Huaiyin Hospital of Huai'an City, Huai'an, Jiangsu 223300, P.R. China.
Xu
X
Xiao
Department of Urology, Huaiyin Hospital of Huai'an City, Huai'an, Jiangsu 223300, P.R. China.
Zhenjia
Z
Dong
Department of Medicine, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China.
Xianqing
X
Ye
Department of Urology, Huaiyin Hospital of Huai'an City, Huai'an, Jiangsu 223300, P.R. China.
Yao
Y
Yan
Department of Urology, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China.
Xuehua
X
Chen
Department of Urology, Huaiyin Hospital of Huai'an City, Huai'an, Jiangsu 223300, P.R. China.
Qin
Q
Pan
Department of Urology, Huaiyin Hospital of Huai'an City, Huai'an, Jiangsu 223300, P.R. China.
Yongfeng
Y
Xie
Department of Urology, Huaiyin Hospital of Huai'an City, Huai'an, Jiangsu 223300, P.R. China.
Jie
J
Xie
Department of Urology, Huaiyin Hospital of Huai'an City, Huai'an, Jiangsu 223300, P.R. China.
Qiangdong
Q
Wang
Department of Urology, Huaiyin Hospital of Huai'an City, Huai'an, Jiangsu 223300, P.R. China.
Qinbo
Q
Yuan
genetic variations; nephrolithiasis; osteopontin gene; susceptibility