The ability to solve elementary logic tasks in mice with the knockout of sodium-calcium exchanger gene 2 (NCX2).
Mice with a knockout of the sodium-calcium exchanger 2 (NCX2) gene were statistically significantly more successful than wild-type controls in the solution of two cognitive tasks, the test for the capacity to extrapolate the direction of the stimulus movement and the "puzzle-box" test for the capacity to find a hidden route to safe environment, which were based on food and aversive motivations, respectively. In both tests, the success of task solution was based on the animal's ability to use the object's "permanence" rule (according to J. Piaget). The data confirm that the knockout of this gene, which is accompanied by modulation of the temporal pattern of calcium membrane flux, also induces changes in mouse CNS plasticity.
Moscow State University, Moscow, 199991, Russia. ingapoletaeva@mail.ru.
I I
II
Poletaeva
Moscow State University, Moscow, 199991, Russia.
O V
OV
Perepelkina
Moscow State University, Moscow, 199991, Russia.
O S
OS
Boyarshinova
Moscow State University, Moscow, 199991, Russia.
V A
VA
Golibrodo
Moscow State University, Moscow, 199991, Russia.
I G
IG
Lilp
Institute of Anatomy, University of Zürich, Zürich, Switzerland.|School of Laboratory Medicine, Kwazulu-Natal University, Durban, South Africa.
H-P
HP
Lipp
Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon, Republic of Korea.
Hee Sup
HS
Shin
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D018782:Maze Learning / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D019831:Sodium-Calcium Exchanger / Q000235:genetics / Q000378:metabolism*
C491739:Slc8a2 protein, mouse; D019831:Sodium-Calcium Exchanger