SIK2 Promotes Ovarian Cancer Spread.
A recent study reveals that the kinase SIK2 helps ovarian cancer cells metastasize and establish themselves in the fat-rich tissues of the abdominal cavity by promoting fatty-acid metabolism and cell proliferation. Mice bearing SIK2-overexpressing human ovarian cancer cells had larger, more abundant metastases than those whose tumors bore an inactive form of the kinase.
D005260:Female; D006801:Humans; D009361:Neoplasm Invasiveness; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology*; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*
C551842:salt-inducible kinase-2, human; D017346:Protein Serine-Threonine Kinases