Associations of Cholesteryl Ester Transfer Protein TaqIB Polymorphism with the Composite Ischemic Cardiovascular Disease Risk and HDL-C Concentrations: A Meta-Analysis.
Previous studies have evaluated the associations between the cholesteryl ester transfer protein (CETP) TaqIB polymorphism (rs708272), the risk of developing composite ischemic cardiovascular disease (CVD) and the concentration of high-density lipoprotein cholesterol (HDL-C), but results remain controversial. The objective of this study was to investigate whether a relationship exists between these factors.



We conducted a meta-analysis of available studies to clarify the associations of the CETP TaqIB polymorphism with HDL-C concentration and the composite ischemic CVD risk in both Asians and Caucasians. All statistical analyses were done with Stata 12.0.



Through utilization of the Cochrane Library, Embase, PubMed, Web of Science, Springer, China Science and Technology Journal Database, China National Knowledge Infrastructure, Google Scholar, and Baidu Library, a total of 45 studies from 44 papers with 20,866 cases and 21,298 controls were combined showing a significant association between the CETP TaqIB variant and composite ischemic CVD risk. Carriers of allele TaqIB-B1 were found to have a higher risk of composite ischemic CVD than non-carriers: OR = 1.15, 95% CI = 1.09-1.21, p < 0.001. Meanwhile, 28 studies with 23,959 subjects were included in the association between the CETP TaqIB polymorphism and the concentration of HDL-C. RESULTS suggested that carriers of the B1B1 genotype had lower concentrations of HDL-C than those of the B2B2 genotype: SMD = 0.50, 95% CI = 0.36-0.65, p < 0.001.



The synthesis of available evidence demonstrates that the CETP TaqIB polymorphism protects against composite ischemic CVD risk and is associated with a higher HDL-C concentration in both Asians and Caucasians.
Department of Preventive Medicine, Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China. pge888@sina.com.|Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (a Joint Venture with the Chinese Ministry of Education), Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China. pge888@sina.com.
Shu-Xia
SX
Guo
Department of Preventive Medicine, Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China. ymhldjxa@sina.com.|Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (a Joint Venture with the Chinese Ministry of Education), Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China. ymhldjxa@sina.com.
Ming-Hong
MH
Yao
Department of Preventive Medicine, Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China. 13399931625@163.com.|Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (a Joint Venture with the Chinese Ministry of Education), Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China. 13399931625@163.com.
Yu-Song
YS
Ding
Department of Preventive Medicine, Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China. yfyxxzjy@126.com.|Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (a Joint Venture with the Chinese Ministry of Education), Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China. yfyxxzjy@126.com.
Jing-Yu
JY
Zhang
Department of Preventive Medicine, Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China. erniu19880215@sina.com.|Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (a Joint Venture with the Chinese Ministry of Education), Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China. erniu19880215@sina.com.
Yi-Zhong
YZ
Yan
Department of Preventive Medicine, Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China. liujiaming@shzu.edu.cn.|Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (a Joint Venture with the Chinese Ministry of Education), Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China. liujiaming@shzu.edu.cn.
Jia-Ming
JM
Liu
Department of Preventive Medicine, Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China. zmberry@foxmail.com.|Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (a Joint Venture with the Chinese Ministry of Education), Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China. zmberry@foxmail.com.
Mei
M
Zhang
Department of Preventive Medicine, Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China. ruidongsheng@gmail.com.|Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (a Joint Venture with the Chinese Ministry of Education), Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China. ruidongsheng@gmail.com.
Dong-Sheng
DS
Rui
Department of Preventive Medicine, Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China. niuqiang1214@163.com.|Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (a Joint Venture with the Chinese Ministry of Education), Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China. niuqiang1214@163.com.
Qiang
Q
Niu
Department of Preventive Medicine, Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China. hejia123.shihezi@163.com.|Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (a Joint Venture with the Chinese Ministry of Education), Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China. hejia123.shihezi@163.com.
Jia
J
He
Department of Preventive Medicine, Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China. guoheng@shzu.edu.cn.|Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (a Joint Venture with the Chinese Ministry of Education), Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China. guoheng@shzu.edu.cn.
Heng
H
Guo
Department of Preventive Medicine, Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China. shzmrl@sina.com.|Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (a Joint Venture with the Chinese Ministry of Education), Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China. shzmrl@sina.com.
Ru-Lin
RL
Ma
D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China; D053480:Cholesterol Ester Transfer Proteins / Q000097:blood* / Q000235:genetics*; D008076:Cholesterol, HDL / Q000097:blood* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000235:genetics*; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D044465:White People / Q000235:genetics*
C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL
HDL-C; cholesteryl ester transfer protein; composite ischemic cardiovascular disease; meta-analysis; polymorphism