Fulminant musculoskeletal and neurologic sarcoidosis: case report and literature update.
We report a case of fulminant sarcoidosis in a 28-year-old man presenting with skin nodules, multifocal small and large joint arthralgias, and blurred vision. Characteristic bone, soft tissue, articular, and CNS findings were evident on multimodality imaging. Bony abnormalities included near-complete destruction of a distal phalanx, "lace-like" lucent lesions, erosive arthritis, lytic lesions with and without sclerotic margins, and bone marrow replacement visible only on MRI. The extent of bony disease at time of presentation was unusual. We review the widely varying reported prevalence of imaging findings of bony sarcoidosis in the literature, and discuss reasons for this variability. We found that musculoskeletal findings at US and MRI were less specific than radiographic and CT findings, but were useful in quantifying extent of disease.
University of Missouri at Columbia, Columbia, MO, USA.
Ashley
A
Sweeney
University of Missouri at Columbia, Columbia, MO, USA.
Richard
R
Hammer
University of Missouri at Columbia, Columbia, MO, USA.
Andrea
A
Evenski
University of Missouri at Columbia, Columbia, MO, USA. crimj@health.missouri.edu.
Julia
J
Crim
D000328:Adult; D001927:Brain Diseases / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D006801:Humans; D007592:Joint Diseases / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D012507:Sarcoidosis / Q000000981:diagnostic imaging*; D013118:Spinal Cord Diseases / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014463:Ultrasonography / Q000379:methods*
Computed tomography (CT); Magnetic resonance imaging (MRI); Sarcoidosis; Ultrasound