Successes and Failures of Combined Modality Therapies in Head and Neck Cancer.
The paradigms for treating head and neck squamous cell carcinoma are changing as new subgroups are defined. The technical successes of improved radiation therapy are many; however, the success of novel combined therapies are few. With the emergence of human papillomavirus and the development of immunooncology agents, such as checkpoint inhibitors, are we ready to reevaluate how we use radiation and chemotherapy for locally advanced and metastatic disease-will we remain the fire or become the fire starter?
Division of Medical Oncology, University of Colorado School of Medicine, Aurora, CO; Department of Medicine, Denver Veterans Affairs Medical Center, Denver, CO. Electronic address: david.raben@ucdenver.edu.
Daniel W
DW
Bowles
Department of Radiotherapy, INSERM 1030 molecular radiotherapy, Université Paris-Sud, Université Paris-Saclay.
Eric
E
Deutsch
Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO.
David
D
Raben
D000970:Antineoplastic Agents / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000556:secondary / Q000628:therapy* / Q000821:virology; D003131:Combined Modality Therapy / Q000379:methods / Q000639:trends; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000628:therapy* / Q000821:virology; D006801:Humans; D011878:Radiotherapy / Q000379:methods
D000970:Antineoplastic Agents