Evaluation of bone loss in antibacterial coated dental implants: An experimental study in dogs.
The aim of this study was to evaluate the in vivo effect of antibacterial modified dental implants in the first stages of peri-implantitis. Thirty dental implants were inserted in the mandibular premolar sites of 5 beagle dogs. Sites were randomly assigned to Ti (untreated implants, 10units), Ti_Ag (silver electrodeposition treatment, 10units), and Ti_TSP (silanization treatment, 10units). Coated implants were characterized by scanning electron microscopy, interferometry and X-ray photoelectron spectroscopy. Two months after implant insertion, experimental peri-implantitis was initiated by ligature placement. Ligatures were removed 2months later, and plaque formation was allowed for 2 additional months. Clinical and radiographic analyses were performed during the study. Implant-tissue samples were prepared for micro computed tomography, backscattered scanning electron microscopy, histomorphometric and histological analyses and ion release measurements. X-ray, SEM and histology images showed that vertical bone resorption in treated implants was lower than in the control group (P<0.05). This effect is likely due to the capacity of the treatments to reduce bacteria colonization on the implant surface. Histological analysis suggested an increase of peri-implant bone formation on silanized implants. However, the short post-ligature period was not enough to detect differences in clinical parameters among implant groups. Within the limits of this study, antibacterial surface treatments have a positive effect against bone resorption induced by peri-implantitis.
Department of Micro- and Nanotechnology, Technical University of Denmark, Kongens Lyngby, Denmark.
Maria
M
Godoy-Gallardo
Unidad de Anatomía y Embriología Humana, Faculty of Dentistry, University of Barcelona, Barcelona, Spain.
Maria Cristina
MC
Manzanares-Céspedes
Department of Mechanics, Escola Universitària Salesiana de Sarrià (EUSS), Barcelona, Spain.
Pablo
P
Sevilla
Department of Periodontology, School of Dentistry, Universitat Internacional de Catalunya, Sant Cugat, Spain.
José
J
Nart
Unidad de Anatomía y Embriología Humana, Faculty of Dentistry, University of Barcelona, Barcelona, Spain.
Norberto
N
Manzanares
Biomaterials, Biomechanics and Tissue Engineering Group, Dept. Materials Science and Metallurgical Engineering, Technical University of Catalonia (UPC-BarcelonaTECH), Barcelona, Spain; Centre for Research in NanoEngineering (CRNE), UPC-BarcelonaTECH, Barcelona, Spain.
José M
JM
Manero
Universitat Internacional de Catalunya, Sant Cugat, Spain.
Francisco Javier
FJ
Gil
McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Alberta, Canada.
Steven K
SK
Boyd
Biomaterials, Biomechanics and Tissue Engineering Group, Dept. Materials Science and Metallurgical Engineering, Technical University of Catalonia (UPC-BarcelonaTECH), Barcelona, Spain; Centre for Research in NanoEngineering (CRNE), UPC-BarcelonaTECH, Barcelona, Spain. Electronic address: daniel.rodriguez.rius@upc.edu.
Daniel
D
Rodríguez
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001862:Bone Resorption / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D020099:Coated Materials, Biocompatible / Q000494:pharmacology / Q000627:therapeutic use*; D015921:Dental Implants / Q000009:adverse effects*; D004285:Dogs; D005260:Female; D005881:Gingiva / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology; D007477:Ions; D013499:Surface Properties
D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D007477:Ions
Antibacterial coating; Dental implants; In vivo; Peri-implantitis; Silver electrodeposition; TESPSA