Clerodens E-J, antibacterial caffeic acid derivatives from the aerial part of Clerodendranthus spicatus.
Six new caffeic acid derivatives, Clerodens E-J (1-6) were isolated from the aerial part of Clerodendranthus spicatus. Their structures were elucidated by extensive spectroscopic analysis, including NMR, MS, and ECD data. Compound 1 showed moderate antibacterial activities against drug-resistant strains of bacteria in vitro.
Hebei TCM Formula Granule Engineering & Technology Research Center, Hebei University of Chinese Medicine, Shijiazhuang 050091, China.
Qing
Q
Li
Hebei TCM Formula Granule Engineering & Technology Research Center, Hebei University of Chinese Medicine, Shijiazhuang 050091, China.
Ying-Na
YN
He
School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China.
Xiao-Wei
XW
Shi
Hebei TCM Formula Granule Engineering & Technology Research Center, Hebei University of Chinese Medicine, Shijiazhuang 050091, China.
Li-Ying
LY
Kang
Hebei TCM Formula Granule Engineering & Technology Research Center, Hebei University of Chinese Medicine, Shijiazhuang 050091, China.
Li-Ying
LY
Niu
Hebei TCM Formula Granule Engineering & Technology Research Center, Hebei University of Chinese Medicine, Shijiazhuang 050091, China. Electronic address: wangxinguozy@126.com.
Xin-Guo
XG
Wang
Hebei TCM Formula Granule Engineering & Technology Research Center, Hebei University of Chinese Medicine, Shijiazhuang 050091, China. Electronic address: rainbow10571@126.com.
Wei
W
Feng
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification; D001419:Bacteria / Q000187:drug effects; D002109:Caffeic Acids / Q000737:chemistry* / Q000302:isolation & purification; D024881:Drug Resistance, Bacterial; D019686:Lamiaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry
D000900:Anti-Bacterial Agents; D002109:Caffeic Acids
Caffeic acid derivatives; Clerodendranthus spicatus; Clerodens E–J