Prospective Cohort Study of the Relative Abundance of Extended-Spectrum-Beta-Lactamase-Producing Escherichia coli in the Gut of Patients Admitted to Hospitals.
A total of 458 patients were prospectively included at hospital admission and screened for extended-spectrum-beta-lactamase-producing (ESBL) Escherichia coli carriage in 2007 and in 2010 to 2012. A 4-fold increase in ESBL carriage (3% to 12%), a 5-fold increase in numbers of community patients among ESBL carriers, and a higher number of multiple ESBL strains was found in the 2010 to 2012 period. ESBL E. coli represented the dominant E. coli strain (relative abundance, >50%) in 10/32 (31%) of ESBL carriers. This represents a major threat in terms of infectious risk and dissemination.
INSERM, IAME, UMR1137, Sorbonne Paris Cité, Paris, France victoire.de-lastours@aphp.fr.|Université Paris Diderot, IAME, UMR1137, Sorbonne Paris Cité, Paris, France.|Assistance-Publique des Hôpitaux de Paris, Service de Médecine Interne, Hôpital Beaujon, Clichy, France.
Victoire
V
de Lastours
INSERM, IAME, UMR1137, Sorbonne Paris Cité, Paris, France.|Université Paris Diderot, IAME, UMR1137, Sorbonne Paris Cité, Paris, France.
Dorothée
D
Chopin
INSERM, IAME, UMR1137, Sorbonne Paris Cité, Paris, France.|Université Paris Diderot, IAME, UMR1137, Sorbonne Paris Cité, Paris, France.|Assistance-Publique des Hôpitaux de Paris, Service de Microbiologie, Hôpital Lariboisière, Paris, France.
Hervé
H
Jacquier
INSERM, IAME, UMR1137, Sorbonne Paris Cité, Paris, France.|Université Paris Diderot, IAME, UMR1137, Sorbonne Paris Cité, Paris, France.
Camille
C
d'Humières
INSERM, IAME, UMR1137, Sorbonne Paris Cité, Paris, France.|Université Paris Diderot, IAME, UMR1137, Sorbonne Paris Cité, Paris, France.
Charles
C
Burdet
INSERM, IAME, UMR1137, Sorbonne Paris Cité, Paris, France.|Université Paris Diderot, IAME, UMR1137, Sorbonne Paris Cité, Paris, France.
Françoise
F
Chau
INSERM, IAME, UMR1137, Sorbonne Paris Cité, Paris, France.|Université Paris Diderot, IAME, UMR1137, Sorbonne Paris Cité, Paris, France.|Assistance-Publique des Hôpitaux de Paris, Laboratoire de Génétique Moléculaire, Hôpital Bichat, Paris, France.
Erick
E
Denamur
INSERM, IAME, UMR1137, Sorbonne Paris Cité, Paris, France.|Université Paris Diderot, IAME, UMR1137, Sorbonne Paris Cité, Paris, France.|Assistance-Publique des Hôpitaux de Paris, Service de Médecine Interne, Hôpital Beaujon, Clichy, France.
Bruno
B
Fantin
D000368:Aged; D058491:Bacterial Load; D002353:Carrier State; D004926:Escherichia coli / Q000235:genetics* / Q000302:isolation & purification*; D005260:Female; D005602:France; D000069196:Gastrointestinal Microbiome; D006761:Hospitals; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D001618:beta-Lactamases / Q000235:genetics*
C473109:beta-lactamase CTX-M-15; D001618:beta-Lactamases