Second primary cancers in patients with urothelial cancers.
To investigate the second primary cancers (SPCs) in patients with urothelial cancer (UC).



The records of 2,339 patients whose UC was diagnosed between January 1974 and December 2012 were reviewed. All data about characteristics of patients, of UC and, of SPC was, recorded digitally. We investigated the prevalence and the type of second or higher order cancers, and the factors associated with SPC.



Total 260 patients (11.1%) had SPC, 14 had a third primary cancer and one had a fourth primary cancer. The most common SPC with UC was lung cancer (29.6%). Of all 260 with SPC, 64 (24.6%) had synchronous (within the 6 months) SPC, 120 (46.2%) had subsequent SPC and, 76 (29.2%) had antecedent SPC. The mean duration of SPC was 56 months in patients with subsequent SPC and 75.8 months in patients with antecedent SPC. The mean age at the time of diagnosis of UC was higher in patients with SPC. The ratio of male gender, body mass index, blood type, status of smoking and, occupational risk was similar in both groups. Total amount of smoking and the mean follow-up were higher in patients with SPC.



The majority of the patients with UC have long life expectancy. In patients with UC, the risk of having another cancer is quite higher than normal population. The physicians managing patients with UC should look for SPC.
Department of Urology, Şifa University Medicine School, İzmir, Turkey.
Ali Feyzullah
AF
Şahin
Department of Urology, Süleyman Demirel University Medicine School, Isparta, Turkey.
Muammer
M
Altok
Department of Urology, MH Tepecik Research and Education Hospital, İzmir, Turkey.
Fırat
F
Akdeniz
Department of Urology, MH Tepecik Research and Education Hospital, İzmir, Turkey.
Güner
G
Yıldız
Department of Urology, Şifa University Medicine School, İzmir, Turkey.
Rauf Taner
RT
Divrik
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000453:epidemiology* / Q000473:pathology; D015995:Prevalence; D012189:Retrospective Studies; D012737:Sex Factors; D014421:Turkey / Q000453:epidemiology; D014571:Urologic Neoplasms / Q000453:epidemiology* / Q000473:pathology; D055815:Young Adult
Multiple primary neoplasms; Second primary neoplasms; Urothelial neoplasms