Designs for phase I trials in ordered groups.
We propose a new design for dose finding for cytotoxic agents in two ordered groups of patients. By ordered groups, we mean that prior to the study there is clinical information that would indicate that for a given dose one group would be more susceptible to toxicities than patients in the other group. The designs are evaluated relative to two previously proposed designs for ordered groups over a range of scenarios generated randomly from a family of dose-toxicity curves. Copyright © 2016 John Wiley & Sons, Ltd.
Division of Translational Research and Applied Statistics, Department of Public Health Sciences, The University of Virginia, 22908, CharlottesvilleVA, U.S.A.
Mark R
MR
Conaway
Division of Translational Research and Applied Statistics, Department of Public Health Sciences, The University of Virginia, 22908, CharlottesvilleVA, U.S.A.
Nolan A
0000-0002-2190-4864
NA
Wages
D000465:Algorithms; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000633:toxicity; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000633:toxicity; D056808:Biostatistics; D017321:Clinical Trials, Phase I as Topic / Q000379:methods* / Q000706:statistics & numerical data; D003198:Computer Simulation; D004305:Dose-Response Relationship, Drug; D006801:Humans; D020714:Maximum Tolerated Dose; D015233:Models, Statistical; D009369:Neoplasms / Q000188:drug therapy
D000970:Antineoplastic Agents
cytotoxic agent; dose-finding; heterogeneous groups