MHC-multimer guided isolation of neoepitopes specific T cells as a potent-personalized cancer treatment strategy.
Analysis of genomic data from patient tumors provides valuable information as to potential T-cell targets such as neoepitopes. We developed an approach to characterize, isolate and utilize neoantigens-specific T cells using MHC/peptide tetramers from fresh tumor digests and peripheral blood. This bears important implications for the implementation of T cell-based immunotherapy.
The Laboratory of Tumor Immunology and Immunotherapy, The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University , Ramat Gan, Israel.
Roni
R
Bareli
The Laboratory of Tumor Immunology and Immunotherapy, The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University , Ramat Gan, Israel.
Cyrille J
CJ
Cohen
Immunotherapy; MHC multimers; T-cells; TCR; neoantigens; tumor immunology