Positive 14-3-3 and tau proteins in a sporadic Creutzfeldt-Jakob disease case and a brief perspective of prion diseases in Colombia.
Prion diseases are rare neurodegenerative disorders occurring worldwide and affecting both humans and animals. Herein, we present the case of a patient diagnosed with definite sporadic Creutzfeldt-Jakob disease in Cali, Colombia. Besides neurological examination, 14-3-3 and tau proteins were valuable tools supporting the diagnosis. We also present a brief perspective of the prion diseases reported in Colombia to date. Although the incidence of prion diseases is unknown in Colombia, our literature review revealed that one case of scrapie in 1981 and 29 human sporadic cases of Creutzfeldt-Jakob disease have been documented and published in our country.
Escuela de Medicina, Facultad de Salud, Universidad del Valle, Cali, Colombia. kevin.escandon@correounivalle.edu.co.
Kevin
K
Escandón-Vargas
Andrés
A
Zorrilla-Vaca
Raúl Heli
RH
Corral-Prado
D048948:14-3-3 Proteins / Q000378:metabolism; D000818:Animals; D015153:Blotting, Western; D003105:Colombia; D007562:Creutzfeldt-Jakob Syndrome / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D015994:Incidence; D017096:Prion Diseases / Q000235:genetics* / Q000378:metabolism; D016875:tau Proteins / Q000235:genetics* / Q000378:metabolism
D048948:14-3-3 Proteins; D016875:tau Proteins
Creutzfeldt-Jakob syndrome; case reports; prions