Chronic skin lichenification as unusual presentation of eosinophilic granulomatosis with polyangitis: case report and literature review.
Eosinophilic granulomatosis with polyangitis (EGPA) is an uncommon ANCA-associated systemic small-vessel necrotizing vasculitis. At times, EGPA presenting manifestations can be very different from the usually recognized disease patterns. We report a 52-year-old female patient with 3 years history of itching. During the time occurred a chronic skin lichenification on her legs and gradually developed a full-blown ANCA-MPO positive EGPA in combination with blood hypereosinophilia, eosinophilic vasculitis at skin biopsy, subclinical asthma and chronic rhinosinusitis.
F
F
Sbrana
B
B
Loggini
S
S
Galimberti
M
M
Coceani
M
M
Latorre
V
V
Seccia
S
S
L'Abbate
M
M
Mosca
E M
EM
Pasanisi
C
C
Baldini
D002908:Chronic Disease; D015267:Churg-Strauss Syndrome / Q000150:complications* / Q000175:diagnosis; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008010:Lichen Planus / Q000209:etiology*; D008875:Middle Aged