[Clinical analyses of the diagnosis and treatment of invasive fungal rhinosinusitis: report of 14 cases].
OBJECTIVE
Through the retrospective analysis of the clinical data in 14 cases of invasive fungal rhinosinusitis (IFRS), the clinical characteristics, diagnosis and treatment of this disease were evaluated.


METHODS
Fourteen clinically confirmed cases of IFRS since January 2008 to October 2015 were evaluated.collected, the clinical features, diagnosis, treatment and prognosis were analyzed to obtain a more comprehensive understanding for clinical reference. Fourteen patients were confirmed by pathological examination as IFRS, including 9 cases of aspergillus, 4 cases of mucor, and 1 case of rhinocerebral zygomycosis; including 5 cases of acute IFRS, 9 cases of chronic IFRS. All patients were treated with endoscopic surgery and intravenous antifungal therapy.


RESULTS
Nine cases of chronic IFRS (including 1 case of mucor, 7 cases of aspergillus and 1 case of rhinocerebral zygomycosis) were cured, but the vision loss, diplopia or blindness, hard palate perforation remained. Five cases of acute IFRS included 3 cases of mucor and 2 cases of aspergillus. Among the 3 cases of mucor, 2 cases were died and 1 case was cured. Among the 2 cases of aspergillus, 1 patient was cured and the other patient died of electrolyte disorder after discharge from hospital.


CONCLUSIONS
Patients with IFRS usually have diabetes. After the active surgical cleaning of lesion tissue and the systematic antifungal treatment with adequate dosage, these patients would have a better result. IFRS caused by mucor is ofen dangerous.
Department of Otorhinolaryngology Head and Neck Surgery, Provinical Hospital, Affiliated to Shandong University, Jinan 250022, China.
G G
GG
Shi
Department of Otorhinolaryngology Head and Neck Surgery, Provinical Hospital, Affiliated to Shandong University, Jinan 250022, China.
L
L
Shi
Department of Otorhinolaryngology Head and Neck Surgery, Provinical Hospital, Affiliated to Shandong University, Jinan 250022, China.
Z Y
ZY
Zhang
Department of Otorhinolaryngology Head and Neck Surgery, Provinical Hospital, Affiliated to Shandong University, Jinan 250022, China.
Y Z
YZ
Wan
Department of Otorhinolaryngology Head and Neck Surgery, Provinical Hospital, Affiliated to Shandong University, Jinan 250022, China.
B
B
Li
Department of Otorhinolaryngology Head and Neck Surgery, Provinical Hospital, Affiliated to Shandong University, Jinan 250022, China.
L
L
Yu
Department of Otorhinolaryngology Head and Neck Surgery, Provinical Hospital, Affiliated to Shandong University, Jinan 250022, China.
E P
EP
Zhang
Department of Otorhinolaryngology Head and Neck Surgery, Provinical Hospital, Affiliated to Shandong University, Jinan 250022, China.
H S
HS
Ju
Department of Otorhinolaryngology Head and Neck Surgery, Provinical Hospital, Affiliated to Shandong University, Jinan 250022, China.
M Q
MQ
He
Department of Otorhinolaryngology Head and Neck Surgery, Provinical Hospital, Affiliated to Shandong University, Jinan 250022, China.
H Z
HZ
Ji
D000208:Acute Disease; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis / Q000628:therapy; D002908:Chronic Disease; D004724:Endoscopy; D006801:Humans; D009091:Mucormycosis / Q000175:diagnosis / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies; D012220:Rhinitis / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy*; D012852:Sinusitis / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy*; D020096:Zygomycosis / Q000175:diagnosis / Q000628:therapy
D000935:Antifungal Agents