A case of adenosquamous cell carcinoma of the gallbladder with markedly elevated PTHrP and G-CSF levels.
A 76-year-old woman was referred to our hospital with anorexia. Computed tomography revealed a tumor lesion measuring 110mm in the liver at S4/5 with calcification and swelling of a paraaortic lymph node. The gallbladder was not visualized. Histological examination of a biopsy specimen from the liver tumor revealed squamous cell and undifferentiated carcinomas, and several tumor markers were elevated. Therefore, we diagnosed the patient with gallbladder adenosquamous cell carcinoma T3N2M0 stage III. Because the serum parathyroid hormone-related protein (PTHrP) and granulocyte-colony stimulating factor (G-CSF) levels were significantly elevated, we suspected that PTHrP and G-CSF production occurred because of adenosquamous cell carcinoma in the gallbladder. We initiated chemotherapy with S-1.
Department of Gastroenterology, Jikei University Daisan Hospital.
Kaoru
K
Ueda
Akiyoshi
A
Kinoshita
Takafumi
T
Akasu
Noriko
N
Hagiwara
Takeharu
T
Yokota
Nami
N
Imai
Akira
A
Iwaku
Nao
N
Fushiya
Kazuhiko
K
Koike
Hirokazu
H
Nishino
D000368:Aged; D001706:Biopsy; D018196:Carcinoma, Adenosquamous / Q000737:chemistry* / Q000000981:diagnostic imaging; D017809:Fatal Outcome; D005260:Female; D005706:Gallbladder Neoplasms / Q000737:chemistry* / Q000000981:diagnostic imaging / Q000473:pathology*; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis / Q000097:blood*; D006801:Humans; D044162:Parathyroid Hormone-Related Protein / Q000096:biosynthesis / Q000097:blood*
D044162:Parathyroid Hormone-Related Protein; D016179:Granulocyte Colony-Stimulating Factor