DAPAR & ProStaR: software to perform statistical analyses in quantitative discovery proteomics.
DAPAR and ProStaR are software tools to perform the statistical analysis of label-free XIC-based quantitative discovery proteomics experiments. DAPAR contains procedures to filter, normalize, impute missing value, aggregate peptide intensities, perform null hypothesis significance tests and select the most likely differentially abundant proteins with a corresponding false discovery rate. ProStaR is a graphical user interface that allows friendly access to the DAPAR functionalities through a web browser.



DAPAR and ProStaR are implemented in the R language and are available on the website of the Bioconductor project (http://www.bioconductor.org/). A complete tutorial and a toy dataset are accompanying the packages.



samuel.wieczorek@cea.fr, florence.combes@cea.fr, thomas.burger@cea.fr.
Université Grenoble Alpes, BIG-BGE, Grenoble, 38000, France.|CEA, BIG-BGE, Grenoble, 38000, France.|INSERM, BGE, Grenoble, 38000, France.
Samuel
S
Wieczorek
Université Grenoble Alpes, BIG-BGE, Grenoble, 38000, France.|CEA, BIG-BGE, Grenoble, 38000, France.|INSERM, BGE, Grenoble, 38000, France.
Florence
F
Combes
Université Grenoble Alpes, BIG-BGE, Grenoble, 38000, France.|CEA, BIG-BGE, Grenoble, 38000, France.|INSERM, BGE, Grenoble, 38000, France.
Cosmin
C
Lazar
Université Grenoble Alpes, BIG-BGE, Grenoble, 38000, France.|CEA, BIG-BGE, Grenoble, 38000, France.|INSERM, BGE, Grenoble, 38000, France.
Quentin
Q
Giai Gianetto
Computational Proteomics Unit, Cambridge, CB2 1GA, UK.|Cambridge Center for Proteomics, Cambridge, CB2 1GA, UK.
Laurent
L
Gatto
Université Grenoble Alpes, BIG-BGE, Grenoble, 38000, France.|CEA, BIG-BGE, Grenoble, 38000, France.|INSERM, BGE, Grenoble, 38000, France.
Alexia
A
Dorffer
Université Grenoble Alpes, BIG-BGE, Grenoble, 38000, France.|CEA, BIG-BGE, Grenoble, 38000, France.|INSERM, BGE, Grenoble, 38000, France.
Anne-Marie
AM
Hesse
Université Grenoble Alpes, BIG-BGE, Grenoble, 38000, France.|CEA, BIG-BGE, Grenoble, 38000, France.|INSERM, BGE, Grenoble, 38000, France.
Yohann
Y
Couté
Université Grenoble Alpes, BIG-BGE, Grenoble, 38000, France.|CEA, BIG-BGE, Grenoble, 38000, France.|INSERM, BGE, Grenoble, 38000, France.
Myriam
M
Ferro
Université Grenoble Alpes, BIG-BGE, Grenoble, 38000, France.|CEA, BIG-BGE, Grenoble, 38000, France.|INSERM, BGE, Grenoble, 38000, France.
Christophe
C
Bruley
Université Grenoble Alpes, BIG-BGE, Grenoble, 38000, France.|CEA, BIG-BGE, Grenoble, 38000, France.|INSERM, BGE, Grenoble, 38000, France.|CNRS, BIG-BGE, Grenoble, 38000, France.
Thomas
T
Burger
D010455:Peptides / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D040901:Proteomics / Q000379:methods*; D012984:Software
D010455:Peptides; D011506:Proteins