Ability of Fractional Flow Reserve to Predict Restenosis After Superficial Femoral Artery Stenting.
To evaluate the clinical efficacy of poststenting fractional flow reserve (FFR) in terms of predicting restenosis in superficial femoral artery (SFA) disease.



This prospective, single-center, nonrandomized study enrolled 48 patients (mean age 76±9 years; 38 men) with 51 SFA lesions from July 2013 to June 2014. Mean FFR (distal mean pressure/proximal mean pressure) and systolic FFR (distal systolic pressure/proximal systolic pressure) were calculated, and the relationship between these FFR values and restenosis at 12 months was investigated using receiver operating characteristic (ROC) curve analysis.



Poststenting FFR was significantly lower in the restenosis group (poststenting mean FFR 0.85±0.07 vs 0.93±0.05, p=0.001; poststenting systolic FFR 0.76±0.14 vs 0.87±0.08, p=0.015). The area under the ROC curve for restenosis in poststenting mean FFR was higher, but not statistically significant, than that in poststenting systolic FFR (0.84 vs 0.74, p=0.08). The best poststenting mean FFR cutoff value for predicting restenosis was 0.92 (sensitivity 0.64, specificity 0.91). The 4.5% restenosis rate at 12 months in the high (>0.92) poststenting mean FFR group was significantly lower (35.7%, p=0.008) than in the low (≤0.92) poststenting mean FFR group.



Poststenting mean FFR is useful for predicting restenosis in SFA disease.
Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan ovation17@gmail.com.
Norihiro
N
Kobayashi
Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan.
Keisuke
K
Hirano
Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan.
Masahiro
M
Yamawaki
Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan.
Motoharu
M
Araki
Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan.
Tsuyoshi
T
Sakai
Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan.
Hideyuki
H
Takimura
Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan.
Yasunari
Y
Sakamoto
Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan.
Shinsuke
S
Mori
Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan.
Masakazu
M
Tsutsumi
Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan.
Takuro
T
Takama
Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan.
Yohsuke
Y
Honda
Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan.
Takahiro
T
Tokuda
Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan.
Kenji
K
Makino
Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan.
Shigemitsu
S
Shirai
Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan.
Yoshiaki
Y
Ito
D000368:Aged; D000369:Aged, 80 and over; D005263:Femoral Artery; D006801:Humans; D008297:Male; D058729:Peripheral Arterial Disease / Q000628:therapy*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D015607:Stents; D016896:Treatment Outcome
angioplasty; endovascular therapy; fractional flow reserve; nitinol stent; occlusion; restenosis; stenosis; superficial femoral artery