Phytochemical Contents and Antioxidant and Antiproliferative Activities of Selected Black and White Sesame Seeds.
Sesame (Sesamum indicum L.) seeds are popular nutritional food but with limited knowledge about their antioxidant and antiproliferative activities of various varieties. Phytochemical profiles and antioxidant and antiproliferative activities of six varieties of sesame (Sesamum indicum L.) seeds were studied. Fenheizhi3 (black) cultivar exhibited the maximum contents of total phenolics and lignans and values of total oxygen radical absorbance capacity (ORAC) and antiproliferative activity (EC50) against HepG2 cells. Bound ORAC values showed strong associations with bound phenolics contents (r = 0.976, p < 0.01); in bound phenolic extracts, EC50 values showed strong negative associations with phenolic contents (r = -0.869, p < 0.05) and ORAC values (r = -0.918, p < 0.01). Moreover, the contents of free phenolics were higher than that of the bound phenolics, and the three black sesame seeds generally depicted higher total phenolics compared to the three white varieties. The antioxidant (ORAC values) and antiproliferation activities of six sesame seeds were both associated with contents of bound phenolics (r > 0.8, p < 0.05). Interestingly, nonlignan components in bound phenolics contributed to the antioxidant and antiproliferative activities. This study suggested that Fenheizhi3 variety is superior to the other five varieties as antioxidant supplements.
Guangdong Province Key Laboratory for Biotechnology Drug Candidates, School of Biosciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China; School of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510641, China.
Lin
0000-0003-4318-5132
L
Zhou
School of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510641, China.
Xiaohui
0000-0003-3848-7048
X
Lin
School of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510641, China; Department of Environmental Sciences, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
Arshad Mehmood
AM
Abbasi
School of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510641, China.
Bisheng
B
Zheng
D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D056945:Hep G2 Cells; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology; D000072257:Oxygen Radical Absorbance Capacity; D019800:Phenol / Q000737:chemistry / Q000494:pharmacology; D064209:Phytochemicals / Q000737:chemistry* / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry*; D031685:Sesamum / Q000737:chemistry*
D000975:Antioxidants; D017705:Lignans; D064209:Phytochemicals; D010936:Plant Extracts; D019800:Phenol