rs2802292 polymorphism in the FOXO3A gene and exceptional longevity in two ethnically distinct cohorts.
OBJECTIVE
Previous studies have indicated that the rs2802292 polymorphism in the human forkhead box O3A (FOXO3A) gene might be associated with exceptional longevity (EL, i.e., living 100+ years), although the results are conflicting.


METHODS
Using a case-control design, we investigated the distribution of the rs2802292 polymorphism in two ethnically distinct cohorts of centenarians (cases) and younger adults (controls). The first cohort included Japanese individuals (733 centenarians and 820 controls) and the second was from Northern Italy (79 disease-free centenarians and 316 controls).


RESULTS
No statistically significant association was found between the rs2802292 polymorphism and EL in either cohort (either examined in their entirety or in a sex-based analysis).


CONCLUSIONS
In light of our negative findings, further research and resequencing efforts are needed to shed more light on the potential association between EL and FOXO3A polymorphisms.
Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan.
Noriyuki
N
Fuku
Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Talca, Chile; Hospital Universitari Institut Pere Mata, IISPV, URV. CIBERSAM, Reus, Spain. Electronic address: roberto.diaz@uautonoma.cl.
Roberto
R
Díaz-Peña
Center for Supercentenarian Medical Research, Keio University School of Medicine, Tokyo, Japan.
Yasumichi
Y
Arai
Center for Supercentenarian Medical Research, Keio University School of Medicine, Tokyo, Japan.
Yukiko
Y
Abe
European University and Research Institute i + 12, Madrid, Spain.
Helios
H
Pareja-Galeano
European University and Research Institute i + 12, Madrid, Spain.
Fabián
F
Sanchis-Gomar
European University and Research Institute i + 12, Madrid, Spain.
Alejandro
A
Santos-Lozano
Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan.
Hirofumi
H
Zempo
Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan.
Hisashi
H
Naito
Department of Health Promotion and Exercise, National Institute of Health and Nutrition, NIBIOHN, Tokyo, Japan.
Haruka
H
Murakami
Department of Health Promotion and Exercise, National Institute of Health and Nutrition, NIBIOHN, Tokyo, Japan.
Motohiko
M
Miyachi
Department of Internal Medicine and Therapeutics, Cellular Pathophysiology and Clinical Immunology Laboratory, University of Pavia, Pavia, Italy.
Letizia
L
Venturini
Department of Internal Medicine and Therapeutics, Cellular Pathophysiology and Clinical Immunology Laboratory, University of Pavia, Pavia, Italy.
Giovanni
G
Ricevuti
Center for Supercentenarian Medical Research, Keio University School of Medicine, Tokyo, Japan.
Hirose
H
Nobuyoshi
2E Science, Robbio (PV), Italy.
Enzo
E
Emanuele
European University and Research Institute i + 12, Madrid, Spain.
Alejandro
A
Lucia
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015331:Cohort Studies; D005006:Ethnicity / Q000235:genetics; D005260:Female; D000071316:Forkhead Box Protein O3 / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007558:Italy; D007564:Japan; D008136:Longevity / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
C499517:FOXO3 protein, human; D000071316:Forkhead Box Protein O3
Aging; Centenarian; FOXO3A; Genetics; Longevity; Polymorphism