Postmenopausal Osteoporosis Is Associated with Serum Chemerin and Irisin but Not with Apolipoprotein M Levels.
OBJECTIVE
The objective of this study was to describe the levels of chemerin, irisin and apolipoprotein M (apoM) in women with postmenopausal osteoporosis.


METHODS
The study included 88 women with postmenopausal osteoporosis. Based on World Health Organization criteria, women with a T-score of ≤ -2.5 were defined as osteoporotic. In this case-control study, postmenopausal women with T-score > -1 were selected as controls (n = 88) and case-matched in a 1:1 ratio based on age (within 2 years) and body mass index (BMI) (within 1.0 kg/m(2)). ApoM, irisin and chemerin levels were determined by a commercially available enzyme-linked immunosorbent assay (ELISA) kit.


RESULTS
There were no significant differences in age, BMI, parity, cholesterol and apoM levels between the two groups. C-reactive protein levels were significantly increased in women with osteoporosis. Serum chemerin levels (240.1 ± 46.1 vs. 261.5 ± 50.8 ng/mL) were significantly lower in the women with osteoporosis, as compared to the controls (P = 0.004). Serum irisin levels were also decreased in women with osteoporosis (0.7 ± 0.2 vs. 0.8 ± 0.2 ng/mL; P = 0.007).


CONCLUSIONS
In the present study, osteoporosis was associated with decreased levels of circulating chemerin and irisin. These findings suggested that adipokines might play a role in the pathogenesis of osteoporosis.
Department of Obstetrics and Gynecology, Faculty of Medicine, Bozok University, Yozgat, Turkey.
Yaprak
Y
Engin-Üstün
Department of Obstetrics and Gynecology, Faculty of Medicine, Bozok University, Yozgat, Turkey.
Emel Kıyak
EK
Çağlayan
Department of Biochemistry, Faculty of Medicine, Bozok University, Yozgat, Turkey.
Ayşe Yeşim
AY
Göçmen
Department of Biochemistry, Faculty of Medicine, Bozok University, Yozgat, Turkey.
Muhammed Fevzi
MF
Polat
Adipokines; Apolipoproteins; Osteoporosis, postmenopausal