Cytomegalovirus seroprevalence in organ donors and kidney transplant recipients, Colombia, 2010-2014.
BACKGROUND
Cytomegalovirus infections have gained high importance for individuals that have received organ transplants given the clinical implications this may have in immunocompromised patients.


OBJECTIVE
To describe the seroprevalence of cytomegalovirus in organ donors and recipients of kidney transplants nationwide from the six regions established by the Red Nacional de Donación y Trasplante.


METHODS
We conducted a descriptive retrospective study that included 1,813 organ donors and 3,313 recipients of kidney transplants, and we calculated IgM and IgG seroprevalence for cytomegalovirus. IgG prevalence was stratified according to sex, age group, and region, and the results were analyzed in each donor-recipient pair and classified according to the risk. Statistical packages IBM SPSS®, Statistics 22, and Epi Info 7 were utilized.


RESULTS
IgG prevalence for cytomegalivirus was 86.8% in donors and 91.0% in kidney transplant recipients with statistical significance observed for age, geographical location, and between donors and recipients. We analyzed 1,764 pairs of donors and recipients, of which 91.4% were categorized as having intermediate risk.


CONCLUSIONS
The results of this study showed high cytomegalovirus infection rates in Colombia. Given the risk, categorization of patients undergoing transplants, measures should be adopted by medical teams to minimize risks.
Subdirección Nacional de Trasplantes y Bancos de Sangre, Dirección de Redes en Salud Pública, Instituto Nacional de Salud, Bogotá, D.C., Colombia. ariasmurillo@hotmail.com.
Yazmín Rocío
YR
Arias-Murillo
Karime
K
Osorio-Arango
Jorge Alberto
JA
Cortés
Mauricio
M
Beltrán
D000914:Antibodies, Viral / Q000097:blood*; D003105:Colombia; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000097:blood* / Q000453:epidemiology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D016030:Kidney Transplantation; D015995:Prevalence; D012189:Retrospective Studies; D016036:Seroepidemiologic Studies; D014019:Tissue Donors / Q000706:statistics & numerical data*
D000914:Antibodies, Viral; D007074:Immunoglobulin G
cytomegalovirus; kidney transplantation; prevalence; seroepidemiologic studies; serology; tissue donor