Recurrent adult onset Henoch-Schonlein Purpura: a case report.
Henoch-Schonlein purpura is an immunoglobulin A (IgA)-immune complex mediated leukocytoclastic vasculitis that classically manifests with palpable purpura, abdominal pain, arthritis, and hematuria or proteinuria. The condition is much more predominant in children (90% of cases) and commonly follows an upper respiratory infection. We present a case of recurrent Henoch-Schonlein purpura (HSP) complicated by nephritis in an adult female initially categorized as IgA nephropathy (IgAN). We review the pathophysiologic basis of HSP nephritis as the variant of HSP accompanied by renal involvement and its pathogenetic commonality with IgA nephropathy.
Neil
N
Gaskill
Bruce
B
Guido
Department of Pathology, Weill Cornell Medicine, New York. cym2003@med.cornell.edu.
Cynthia
CM
Magro
D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D005922:Glomerulonephritis, IGA / Q000175:diagnosis; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D007070:Immunoglobulin A / Q000276:immunology; D009393:Nephritis / Q000175:diagnosis* / Q000209:etiology; D012008:Recurrence; D012867:Skin / Q000473:pathology
D007070:Immunoglobulin A