Failure of sucrose replacement with the non-nutritive sweetener erythritol to alter GLP-1 or PYY release or test meal size in lean or obese people.
There is considerable interest in the effect of foods containing high intensity sweeteners on satiation. However, less is known about low-calorie bulk sweeteners such as erythritol. In this randomized three-way crossover study, we studied 10 lean and 10 obese volunteers who consumed three test meals on separate occasions: (a) control sucrose meal; (b) isovolumic meal with partial replacement of sucrose by erythritol; (c) isocaloric meal which contained more erythritol but equivalent calories to the control meal. We measured gut hormone levels, hunger and satiety scores, ad libitum food intake, sucrose preference and intake after the manipulations. There was a greater post-prandial excursion in glucose and insulin levels after sucrose than after the erythritol meals. There was no difference in GLP-1/PYY levels or subsequent energy intake and sucrose preference between sucrose control and isovolumic erythritol meals. In lean (but not obese) participants, hunger decreased to a greater extent after the isocaloric erythritol meal compared to the control meal (p = 0.003) reflecting the larger volume of this meal. Replacing sucrose with erythritol leads to comparable hunger and satiety scores, GLP-1 and PYY levels, and subsequent sucrose preference and intake.
NIZO Food Research, Ede, The Netherlands.
Joost
J
Overduin
University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.
Tinh-Hai
TH
Collet
University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom; Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom.
Nenad
N
Medic
University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.
Elana
E
Henning
University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.
Julia M
JM
Keogh
University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.
Faye
F
Forsyth
University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.
Cheryl
C
Stephenson
NIZO Food Research, Ede, The Netherlands.
Marja W
MW
Kanning
NIZO Food Research, Ede, The Netherlands.
Rianne M A J
RMAJ
Ruijschop
University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.
I Sadaf
IS
Farooqi
University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom. Electronic address: av330@medschl.cam.ac.uk.
Agatha A
AA
van der Klaauw
D000328:Adult; D018592:Cross-Over Studies; D004896:Erythritol / Q000494:pharmacology*; D005260:Female; D052216:Glucagon-Like Peptide 1 / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D006815:Hunger / Q000187:drug effects; D008297:Male; D062407:Meals / Q000187:drug effects; D008875:Middle Aged; D064306:Non-Nutritive Sweeteners / Q000494:pharmacology*; D009765:Obesity / Q000378:metabolism*; D019894:Peptide YY / Q000187:drug effects* / Q000378:metabolism; D019518:Postprandial Period; D012527:Satiation / Q000187:drug effects; D013395:Sucrose / Q000494:pharmacology; D013549:Sweetening Agents / Q000494:pharmacology
D064306:Non-Nutritive Sweeteners; D013549:Sweetening Agents; D019894:Peptide YY; D013395:Sucrose; D052216:Glucagon-Like Peptide 1; D004896:Erythritol
Erythritol; Glucagon-like peptide 1; Obesity; Peptide YY; Sweeteners