Role of the PI3K-Akt Signaling Pathway in the Pathogenesis of Polycystic Ovary Syndrome.
This review aimed to focus on the recent progress of the understanding of the role of phosphatidylinositol 3-kinase (PI3K) in polycystic ovary syndrome (PCOS). In recent years, it has been increasingly recognized that PI3K plays an important role in PCOS whose pathogenesis is unclear. However, research continues into revealing the details of how PI3Ks are involved in developing PCOS. Previous studies have shown that activation of the PI3K-protein kinase B (Akt) signaling pathway has important effects on insulin resistance and endometrial cancer. Knowledge of the action of PI3K in PCOS might provide valuable information to further validate the pathogenesis of PCOS and suggest new methods of treatment.
1 Department of Obstetrics and Gynecology, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou, China.
Tiantian
T
Li
2 Laboratory of Chinese Medicine Quality Research, Macau University of Science and Technology, Macau, China.
Hui
H
Mo
1 Department of Obstetrics and Gynecology, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou, China.
Wenfeng
W
Chen
1 Department of Obstetrics and Gynecology, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou, China.|2 Laboratory of Chinese Medicine Quality Research, Macau University of Science and Technology, Macau, China.
Li
L
Li
2 Laboratory of Chinese Medicine Quality Research, Macau University of Science and Technology, Macau, China.
Yao
Y
Xiao
3 Guangzhou Family Planning Specialty Hospital, Guangzhou, China.
Jing
J
Zhang
1 Department of Obstetrics and Gynecology, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou, China.
Xiaofang
X
Li
1 Department of Obstetrics and Gynecology, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou, China.
Ying
Y
Lu
D017667:Adipocytes / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D058539:Phosphatidylinositol 3-Kinase / Q000378:metabolism*; D011085:Polycystic Ovary Syndrome / Q000378:metabolism*; D015398:Signal Transduction
D058539:Phosphatidylinositol 3-Kinase
PI3K-Akt; insulin resistance; pathogenesis; polycystic ovary syndrome; signaling pathway