Cilia and Nuclear Pore Proteins: Pore No More?
Nuclear pore proteins at the base of cilia were thought to regulate transport into cilia. In this issue of Developmental Cell, Del Viso et al. (2016) challenge this view, showing instead that pore proteins localize to ciliary basal bodies and that their perturbation leads to congenital heart disease.
Laboratory of Cellular and Structural Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Samson O
SO
Obado
Laboratory of Cellular and Structural Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address: rout@mail.rockefeller.edu.
Michael P
MP
Rout
D002923:Cilia / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006330:Heart Defects, Congenital / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D022022:Nuclear Pore / Q000378:metabolism; D028861:Nuclear Pore Complex Proteins / Q000235:genetics / Q000378:metabolism*; D021381:Protein Transport / Q000235:genetics
D028861:Nuclear Pore Complex Proteins