PD-1/PD-L1 expression in extra-medullary lesions of multiple myeloma.
Multiple myeloma patients may develop extraosseous involvement in the course of the disease making prognosis very poor and new drugs clearly needed. The PD-1/PD-L1 axis has emerged as a master immune checkpoint in antitumor responses and recent studies investigated the role of PD-L1 in multiple myeloma cells; no data however are still available about PD-L1 expression in extramedullary localizations. We demonstrate PD-L1 expression in 4/12 cases of extraosseous myeloma suggesting that these lesions represent a specialized microenvironment. We found presence of PD-1+ infiltrating lymphocytes in all observed cases supporting the relevance of PD-1/PD-L1 checkpoint in extramedullary myeloma. We also investigated the correlation in PD1/PD-L1 staining between marrow staining and EMP lesions.
Unit of Pathology, University Hospital Campus Bio-Medico, Rome, Italy. Electronic address: a.crescenzi@unicampus.it.
Anna
A
Crescenzi
Unit of Haematology, Stem Cell Transplantation, Transfusion Medicine and Cellular Therapy, University Hospital Campus Bio-Medico, Rome, Italy.
Ombretta
O
Annibali
Unit of Pathology, University Hospital Campus Bio-Medico, Rome, Italy.
Antonella
A
Bianchi
Unit of Haematology, Stem Cell Transplantation, Transfusion Medicine and Cellular Therapy, University Hospital Campus Bio-Medico, Rome, Italy.
Anastasia
A
Pagano
Unit of Pathology, University Hospital Campus Bio-Medico, Rome, Italy.
Michele
M
Donati
Proxagen Ltd, Sofia, Bulgaria.
Alba
A
Grifoni
Unit of Haematology, Stem Cell Transplantation, Transfusion Medicine and Cellular Therapy, University Hospital Campus Bio-Medico, Rome, Italy.
Giuseppe
G
Avvisati
D000328:Adult; D000368:Aged; D060890:B7-H1 Antigen / Q000032:analysis*; D001856:Bone Marrow Examination; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D017254:Leukemic Infiltration / Q000473:pathology; D008875:Middle Aged; D009101:Multiple Myeloma / Q000473:pathology*; D061026:Programmed Cell Death 1 Receptor / Q000032:analysis*
D060890:B7-H1 Antigen; C423236:CD274 protein, human; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor
Extramedullary myeloma; Immunohistochemistry; PD-1; PD-L1