Hypoglycemic and anti-hyperglycemic activity of Triphalādi granules in mice.
BACKGROUND
Triphalādi kvātha is well known herbal Ayurvedic formulation used in Prameha (~type 2 diabetes mellitus). In the present study, kvātha was converted into granules and assessed for its hypoglycemic and anti-hyperglycemic effects in albino mice.


METHODS
Triphalādi granules (650 mg/kg, p.o.) were administered in normal albino mice for assessment of hypoglycemic activity. Anti-hyperglycemic activity of Triphalādi granules was assessed in glucose (5 g/kg, p.o.) solution overloaded mice. The blood sugar level (BSL) was measured with the help of one touch easy glucometer.


RESULTS
Triphalādi granules produced significant decrease in blood glucose level after one hour in comparison to initial values while decreasing BSL by 27.92% in comparison to control group in normal albino mice. In hyperglycemic study, Triphalādi granules produced significant decrease the BSL after 2 hr. of administration compared to control group.


CONCLUSIONS
Triphalādi granules have significant hypoglycemic and anti-hyperglycemic activity in mice with minimal effect on BSL below normal range. The studies suggest the potential role of Triphalādi granules as an alternative adjuvant therapy in diabetic individuals for the control of the blood glucose level.
Department of Kayachikitsa, IPGT and RA, Gujarat Ayurved University, Jamnagar, Gujarat, India.
Ankush
A
Gunjal
Department of Rasashastra and Bhaishajya Kalpana, IPGT and RA, Gujarat Ayurved University, Jamnagar, Gujarat, India.
Manisha
M
Walunj
Department of Pharmacology, Pharmacology Laboratory, IPGT and RA, Gujarat Ayurved University, Jamnagar, Gujarat, India.
Hetal
H
Aghera
Department of Pharmacology, Pharmacology Laboratory, IPGT and RA, Gujarat Ayurved University, Jamnagar, Gujarat, India.
Mukesh
M
Nariya
Department of Kayachikitsa, IPGT and RA, Gujarat Ayurved University, Jamnagar, Gujarat, India.
Mandip R
MR
Goyal
Anti-hyperglycemic activity; Triphalādi granules; diabetes mellitus; hypoglycemic activity