Cryptococcal osteomyelitis of the skull in a liver transplant patient.
Cryptococcus neoformans is an opportunistic fungal pathogen and an important cause of morbidity and mortality in immunocompromised patients. We report a case of osteomyelitis caused by C. neoformans in a liver transplant recipient who presented with a headache and scalp lump after sustaining mild head trauma. There was no evidence of central nervous system involvement or dissemination. This is the first known case report of isolated cryptococcal osteomyelitis in a liver transplant recipient.
AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Aviv V
AV
Pudipeddi
AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Ken
K
Liu
Department of Pathology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Geoffrey F
GF
Watson
Department of Microbiology and Infectious Diseases, Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia.
Rebecca J
RJ
Davis
AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Simone I
SI
Strasser
D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D001706:Biopsy; D015209:Cholangitis, Sclerosing / Q000601:surgery*; D003399:Craniotomy; D003453:Cryptococcosis / Q000150:complications / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D003455:Cryptococcus neoformans / Q000302:isolation & purification*; D003646:Debridement; D006261:Headache / Q000209:etiology; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D009894:Opportunistic Infections / Q000150:complications / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D010019:Osteomyelitis / Q000150:complications / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D012886:Skull; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D014057:Tomography, X-Ray Computed
D000935:Antifungal Agents; D007166:Immunosuppressive Agents
Cryptococcosis; fungal infection; immunosuppressed host; liver transplantation; opportunistic infection; osteomyelitis