FOXE1 Polymorphism Interacts with Dietary Iodine Intake in Differentiated Thyroid Cancer Risk in the Cuban Population.
The incidence of differentiated thyroid cancer (DTC) is low in Cuba, and the contribution of dietary factors to DTC in this population has not been investigated so far. The aim of this study was to evaluate the relationship between dietary iodine intake and DTC with regard to the interaction with environmental factors or some common single nucleotide polymorphisms (SNPs), based on a case-control study carried out in Cuba.



A total of 203 cases and 212 controls from the general population were interviewed face-to-face using the dietary intake questionnaire and the photo booklet from the E3N cohort. A specific food composition table was constructed for this study. For each parameter studied, the odds ratio (OR) was stratified on age group and sex, and further adjusted for dietary energy, smoking status, ethnic group, level of education, number of pregnancies, and body surface area.



The risk of DTC was significantly reduced with increasing consumption of fish (p = 0.04), but no association between total dietary iodine intake and DTC risk was evident (p = 0.7). This lack of significant association was true whatever the age, the smoking status, the dietary selenium intake, and the ethnicity (p > 0.05). DTC risk was positively and strongly associated with the number of copies in the minor allele (A) for SNP rs965513 near FOXE1 among people who consumed less iodine than the median (p = 0.005).



Overall, the majority of the studied population had an optimal dietary iodine intake. DTC risk was inversely associated with high fish consumption. Furthermore, DTC risk was positively associated with the number of copies in the minor allele (A) of rs965513 among people who consumed less iodine than the median. Because these findings are based on post-diagnostic measures, studies with pre-diagnostic dietary iodine are needed for confirmation.
1 Cancer and Radiations, Center for Research in Epidemiology and Population Health (CESP) - U1018, French National Institute of Health and Medical Research (INSERM), Villejuif, France .|2 Department of Research, Gustave Roussy Institute , Villejuif, France .|3 Faculty of Medicine, University of Paris XI , Le Kremlin-Bicêtre, France .
Yan
Y
Ren
4 Department of Clinical Research, Institute of Oncology and Radiobiology , Havana, Cuba .
Juan J
JJ
Lence-Anta
4 Department of Clinical Research, Institute of Oncology and Radiobiology , Havana, Cuba .
Celia M
CM
Pereda
4 Department of Clinical Research, Institute of Oncology and Radiobiology , Havana, Cuba .
Mae
M
Chappe
4 Department of Clinical Research, Institute of Oncology and Radiobiology , Havana, Cuba .
Milagros
M
Velasco
4 Department of Clinical Research, Institute of Oncology and Radiobiology , Havana, Cuba .
Idalmis
I
Infante
4 Department of Clinical Research, Institute of Oncology and Radiobiology , Havana, Cuba .
Marlene
M
Bustillo
5 Medical Care, National Institute of Endocrinology , Havana, Cuba .
Silvia
S
Turcios
6 Laboratory for Food Safety, Department of Chemical Contaminants in Food, Metallic Trace Elements and Minerals Unit, University of Paris-Est , Anses, Maisons-Alfort, France .
Axelle
A
Leufroy
6 Laboratory for Food Safety, Department of Chemical Contaminants in Food, Metallic Trace Elements and Minerals Unit, University of Paris-Est , Anses, Maisons-Alfort, France .
Thierry
T
Guérin
7 The French Directorate General for Food, Ministry of Agriculture , Agro-16 Food and Forestry, Paris, France .
Laurent
L
Noël
8 Institut Curie, Mines ParisTech, U900, French National Institute of Health and Medical Research (INSERM), Paris, France .
Fabienne
F
Lesueur
1 Cancer and Radiations, Center for Research in Epidemiology and Population Health (CESP) - U1018, French National Institute of Health and Medical Research (INSERM), Villejuif, France .|2 Department of Research, Gustave Roussy Institute , Villejuif, France .|3 Faculty of Medicine, University of Paris XI , Le Kremlin-Bicêtre, France .
Stéphane
S
Maillard
1 Cancer and Radiations, Center for Research in Epidemiology and Population Health (CESP) - U1018, French National Institute of Health and Medical Research (INSERM), Villejuif, France .|2 Department of Research, Gustave Roussy Institute , Villejuif, France .|3 Faculty of Medicine, University of Paris XI , Le Kremlin-Bicêtre, France .
Enora
E
Cléro
1 Cancer and Radiations, Center for Research in Epidemiology and Population Health (CESP) - U1018, French National Institute of Health and Medical Research (INSERM), Villejuif, France .|2 Department of Research, Gustave Roussy Institute , Villejuif, France .|3 Faculty of Medicine, University of Paris XI , Le Kremlin-Bicêtre, France .
Constance
C
Xhaard
1 Cancer and Radiations, Center for Research in Epidemiology and Population Health (CESP) - U1018, French National Institute of Health and Medical Research (INSERM), Villejuif, France .|2 Department of Research, Gustave Roussy Institute , Villejuif, France .|3 Faculty of Medicine, University of Paris XI , Le Kremlin-Bicêtre, France .
Rodrigue S
RS
Allodji
1 Cancer and Radiations, Center for Research in Epidemiology and Population Health (CESP) - U1018, French National Institute of Health and Medical Research (INSERM), Villejuif, France .|2 Department of Research, Gustave Roussy Institute , Villejuif, France .|3 Faculty of Medicine, University of Paris XI , Le Kremlin-Bicêtre, France .
Carole
C
Rubino
9 Department of Foreign Affairs, Public Health Ministry, Havana, Cuba .
Regla
R
Rodriguez
4 Department of Clinical Research, Institute of Oncology and Radiobiology , Havana, Cuba .
Rosa M
RM
Ortiz
1 Cancer and Radiations, Center for Research in Epidemiology and Population Health (CESP) - U1018, French National Institute of Health and Medical Research (INSERM), Villejuif, France .|2 Department of Research, Gustave Roussy Institute , Villejuif, France .|3 Faculty of Medicine, University of Paris XI , Le Kremlin-Bicêtre, France .
Florent
F
de Vathaire
D000293:Adolescent; D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D003462:Cuba; D004032:Diet; D005260:Female; D051858:Forkhead Transcription Factors / Q000235:genetics*; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007455:Iodine / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D013964:Thyroid Neoplasms / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D055815:Young Adult
C106894:FOXE1 protein, human; D051858:Forkhead Transcription Factors; D007455:Iodine
DNA polymorphisms; case-control study; dietary iodine intake; food composition table; thyroid cancer