Changes in minimum inhibitory concentration of levofloxacin for Escherichia coli strains isolated from urine samples in mainland China, 2004 to 2014.
Eschrichia coli urinary isolates were collected from 20 Chinese hospitals during five 1-year periods from 2004 to 2014. The susceptibility of E. coli to levofloxacin has remained stable during the past 11 years, and 90% of strains had minimum inhibitory concentrations of ≤32 mg/L. The urine-specific susceptibility breakpoints for levofloxacin should be reset based on more relevant clinical studies and the current pharmacokinetic/pharmacodynamic considerations in this field.
Institute of Clinical Pharmacology, Peking University First Hospital, Beijing 100034, China.
Yun
Y
Li
Institute of Clinical Pharmacology, Peking University First Hospital, Beijing 100034, China. Electronic address: doctorzhengbo@163.com.
Bo
B
Zheng
Institute of Clinical Pharmacology, Peking University First Hospital, Beijing 100034, China.
Feng
F
Xue
Department of Biostatistics, Peking University First Hospital, Beijing 100034, China.
Sai-Nan
SN
Zhu
Institute of Clinical Pharmacology, Peking University First Hospital, Beijing 100034, China.
Yuan
Y
Lyu
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002681:China; D004926:Escherichia coli / Q000187:drug effects* / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000382:microbiology*; D006801:Humans; D064704:Levofloxacin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D014552:Urinary Tract Infections / Q000382:microbiology*; D014556:Urine / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D064704:Levofloxacin
Escherichia coli; levofloxacin; susceptibility; urinary tract infection