Glucose Metabolism: A Sweet Relief of Alzheimer's Disease.
Patients and individuals at risk for Alzheimer's disease show reduced glucose metabolism in the brain. A new study takes advantage of a fly model of Alzheimer's disease to demonstrate that enhancing glucose uptake in neurons has strong neuroprotective effects involving improved proteostasis.
Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile.
Claudia
C
Duran-Aniotz
Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile; Buck Institute for Research on Aging, Novato, CA 94945, USA. Electronic address: chetz@med.uchile.cl.
Claudio
C
Hetz
D000544:Alzheimer Disease; D001921:Brain; D050260:Carbohydrate Metabolism; D005947:Glucose; D006801:Humans; D009474:Neurons
D005947:Glucose