Detection of glucose in the human brain with1H MRS at 7 Tesla.
A new method is proposed for noninvasive detection of glucose in vivo using proton MR spectroscopy at 7 Tesla.



The proposed method utilizes J-difference editing to uncover the resonance of beta-glucose (β-glc) at 3.23 ppm, which is strongly overlapped with choline. Calculations using the density matrix formalism are used to maximize the signal-to-noise ratio of the β-glc resonance at 3.23 ppm. The calculations are verified using phantom and in vivo data collected at 7 Tesla.



The proposed method allows observation of the glucose signal at 3.23 ppm in the human brain spectrum. Additional co-edited resonances of N-acetylaspartylglutamatate and glutathione are also detected in the same experiment.



The proposed method does not require carbon (13C)- labeled glucose injections and13C hardware; as such, it has a potential to provide valuable information on intrinsic glucose concentration in the human brain in vivo. Magn Reson Med 76:1653-1660, 2016. © 2016 International Society for Magnetic Resonance in Medicine.
Siemens Healthcare KK, Tokyo, Japan.
Lana G
LG
Kaiser
Siemens Healthcare KK, Tokyo, Japan.
Kawaguchi
K
Hirokazu
National Institute for Physiological Sciences, Okazaki, Aichi, Japan.
Masaki
M
Fukunaga
University of California, San Francisco, California, USA.
Gerald
G
B Matson
D000328:Adult; D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D057054:Molecular Imaging / Q000379:methods*; D066244:Proton Magnetic Resonance Spectroscopy / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014018:Tissue Distribution
D005947:Glucose
7 Tesla; MRS; glucose; human brain; jedit-SLASER; numerical simulations