VEGF-A/VEGFR2 signaling network in endothelial cells relevant to angiogenesis.
Vascular endothelial growth factor-A (VEGF-A) is essential for endothelial cell functions associated with angiogenesis. Signal transduction networks initiated by VEGFA/VEGFR2, the most prominent ligand-receptor complex in the VEGF system, leads to endothelial cell proliferation, migration, survival and new vessel formation involved in angiogenesis. Considering its biomedical importance, we have developed the first comprehensive map of endothelial cell-specific signaling events of VEGFA/VEGFR2 system pertaining to angiogenesis. Screening over 20,000 published research articles and following the post-translational modification (PTM) and site specificity of VEGFR2, we have documented 240 proteins and their diverse PTM-dependent reactions involved in VEGFA/VEGFR2 signal transduction. From the ligand-receptor complex, this map has been extended to the level of major transcriptionally regulated genes for which the signaling cascades leading to their transcription factors are reported. We believe that this map would serve as a novel platform for reference, integration, and representation and more significantly, the progressive analysis of dynamic features of VEGF signaling in endothelial cells including their cross-talks with other ligand-receptor systems involved in angiogenesis.
Department of Computational Biology and Bioinformatics, University of Kerala, Kariavattom, Thiruvananthapuram, Kerala, 695 581, India.
Chandran S
CS
Abhinand
Computational Biology Group, Cancer Research Program-9, Rajiv Gandhi Centre for Biotechnology, KINFRA Campus, Thiruvananthapuram, Kerala, -695 585, India.
Rajesh
R
Raju
Inter-University Centre for Genomics and Gene Technology, University of Kerala, Kariavattom, Thiruvananthapuram, Kerala, 695 581, India.
Sasikumar J
SJ
Soumya
Department of Computational Biology and Bioinformatics, University of Kerala, Kariavattom, Thiruvananthapuram, Kerala, 695 581, India.
Prabha S
PS
Arya
Department of Computational Biology and Bioinformatics, University of Kerala, Kariavattom, Thiruvananthapuram, Kerala, 695 581, India. prslab@gmail.com.
Perumana R
PR
Sudhakaran
KDR; Pathway map; Phosphosite mapping; Vascular endothelial growth factor