A split-body, randomized, blinded study to evaluate the efficacy of a topical spray composed of essential oils and essential fatty acids from plant extracts with antimicrobial properties.
BACKGROUND
Bacterial pyoderma is a frequent presentation in dogs. Despite the widespread availability of effective systemic and topical antimicrobial products, good clinical practice currently recommends avoidance of long-term use to mitigate the development of bacterial resistance.


OBJECTIVE
To evaluate the speed of resolution of clinical signs of bacterial pyoderma in dogs treated with a systemic antimicrobial agent with or without the use of an adjunctive spray with antimicrobial properties.


METHODS
Twelve dogs with superficial bacterial pyoderma.


METHODS
In this controlled and blinded study, all dogs were treated with oral cefalexin and a topical spray (PYOClean Spray) for 4 weeks. The spray was applied to one half of each dog's body, whereas a placebo spray was applied to the other half.


RESULTS
Twelve dogs completed the study. Mean clinical scores were significantly reduced on spray-treated sites, for test product and placebo (respectively), by 47% and 34% at Week 1, 83% and 60% at Week 2, 95% and 82% at Week 3, and 100% and 96% at Week 4. Fifty percent of treated sites were considered clinically and cytologically cured at Week 2, 83% at Week 3, and 100% at Week 4 compared to 8%, 50% and 83% for the placebo sites, respectively.


CONCLUSIONS
These results demonstrate that use of a topical spray which contains plant-derived essential oils and fatty acids, and compounds with antimicrobial properties (Manuka oil and N-acetyl cysteine) may help to speed resolution of pyoderma and may allow for shorter antimicrobial treatment time.
Dermatology Referral Service, Clinique Vétérinaire, 6 rue mare pavée, 35510, Rennes-Cesson, France.
Emmanuel
E
Bensignor
Laboratoire de Dermo-Cosmétique Animale (LDCA), ZA Le Causse, 81100, Castres, France.
Lionel
L
Fabriès
Laboratoire de Dermo-Cosmétique Animale (LDCA), ZA Le Causse, 81100, Castres, France.
Lucie
L
Bailleux
D000287:Administration, Topical; D000336:Aerosols; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005227:Fatty Acids / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D009822:Oils, Volatile / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011711:Pyoderma / Q000188:drug therapy / Q000662:veterinary*
D000336:Aerosols; D005227:Fatty Acids; D009822:Oils, Volatile; D010936:Plant Extracts