Correlation between adipokines and carotid intima media thickness in a group of obese Romanian children: is small for gestational age status an independent factor for cardiovascular risk?
OBJECTIVE
To investigate the relationship between markers of adiposity and common carotid artery (CIMT) in obese children born small for gestational age (SGA) versus appropriate for gestational age (AGA), to establish cut-off values for CIMT in obese pediatric populations.


METHODS
A cross-sectional study was carried out over a 1-year period (Jul 2013 - June 2014). We analyzed 122 obese patients aged 4-20 (mean age 14.9 ± 2.28). Twenty-six patients were born SGA. CIMT was measured in all the patients. Using ROC curve, cut-off values were obtained for both groups.


RESULTS
We demonstrated a correlation between CIMT and adiponectin, leptin and high sensitivity C-reactive protein (hsCRP) (r = -0.25, r = 0.279, r = 0.498) in obese children. CIMT in obese children born SGA were significantly increased as compared with obese children born AGA of similar age, sex and body mass index (BMI) (p = 0.0035). A CIMT cut off value of 0.049 cm has been obtained with a high sensitivity and specificity.


CONCLUSIONS
CIMT is a well-known marker of subclinical atherosclerosis and its measurement is a noninvasive and inexpensive method of detecting subclinical atherosclerosis. Being born SGA increases the atherogenic risk. Obese children with CIMT above 0.049 cm should be screened for metabolic syndrome (MetS).
"Louis Turcanu" Emergency Hospital for Children, Timişoara, România.|"Victor Babes" University of Medicine and Pharmacy, Timişoara, România.
Ramona
R
Stroescu
"Louis Turcanu" Emergency Hospital for Children, Timişoara, România.|"Victor Babes" University of Medicine and Pharmacy, Timişoara, România.
Teofana
T
Bizerea
"Louis Turcanu" Emergency Hospital for Children, Timişoara, România.|"Victor Babes" University of Medicine and Pharmacy, Timişoara, România.
Gabriela
G
Doroş
"Louis Turcanu" Emergency Hospital for Children, Timişoara, România.
Monica
M
Marazan
"Louis Turcanu" Emergency Hospital for Children, Timişoara, România.
Maria
M
Lesovici
"Louis Turcanu" Emergency Hospital for Children, Timişoara, România.|"Victor Babes" University of Medicine and Pharmacy, Timişoara, România.
Otilia
O
Mãrginean
D054392:Adipokines / Q000097:blood*; D000293:Adolescent; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000209:etiology*; D059168:Carotid Intima-Media Thickness; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007236:Infant, Small for Gestational Age; D020738:Leptin / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood / Q000150:complications*; D012307:Risk Factors; D012383:Romania; D012680:Sensitivity and Specificity; D055815:Young Adult
D054392:Adipokines; D020738:Leptin; D002097:C-Reactive Protein