Ring Chromosome 4 in a Child with Multiple Congenital Abnormalities: A Case Report and Review of the Literature.
A female child born preterm with intrauterine growth retardation and presenting with facial dysmorphism with clefts, microcephaly, limb deformities, and congenital abnormalities involving cardiovascular and urinary systems is described. Chromosomal analysis showed a de novo 46,XX,r(4)(p15.3q35) karyotype. The clinical features of the patient were compared with the phenotypic characteristics of 17 previously reported cases with ring chromosome 4 and those with Wolf-Hirschhorn syndrome (4p-). Clinical features observed in this case are consistent with the consensus phenotype in ring chromosome 4. Patent ductus arteriosus and bilateral talipes equinovarus observed in this baby widen the phenotypic spectrum associated with ring chromosome 4.
Human Genetics Unit, Faculty of Medicine, University of Colombo, 00800 Colombo, Sri Lanka.
C S
0000-0001-9214-7808
CS
Paththinige
Human Genetics Unit, Faculty of Medicine, University of Colombo, 00800 Colombo, Sri Lanka.
N D
0000-0003-0994-6954
ND
Sirisena
Human Genetics Unit, Faculty of Medicine, University of Colombo, 00800 Colombo, Sri Lanka.
U G I U
0000-0003-3540-8607
UG
Kariyawasam
Castle Street Hospital for Women, 00800 Colombo, Sri Lanka.
L P C
LP
Saman Kumara
Human Genetics Unit, Faculty of Medicine, University of Colombo, 00800 Colombo, Sri Lanka.
V H W
0000-0002-3264-6856
VH
Dissanayake