Micro-CT based finite element models for elastic properties of glass-ceramic scaffolds.
In this study, the mechanical properties of porous glass-ceramic scaffolds are investigated by means of three-dimensional finite element models based on micro-computed tomography (micro-CT) scan data. In particular, the quantitative relationship between the morpho-architectural features of the obtained scaffolds, such as macroscopic porosity and strut thickness, and elastic properties, is sought. The macroscopic elastic properties of the scaffolds have been obtained through numerical homogenization approaches using the mechanical characteristics of the solid walls of the scaffolds (assessed through nanoindentation) as input parameters for the numerical simulations. Anisotropic mechanical properties of the produced scaffolds have also been investigated by defining a suitable anisotropy index. A comparison with morphological data obtained through the micro-CT scans is also presented. The proposed study shows that the produced glass-ceramic scaffolds exhibited a macroscopic porosity ranging between 29% and 97% which corresponds to an average stiffness ranging between 42.4GPa and 36MPa. A quantitative estimation of the isotropy of the macroscopic elastic properties has been performed showing that the samples with higher solid fractions were those closest to an isotropic material.
Department of Chemistry, Materials and Chemical Engineering, Laboratory of Biological Structure Mechanics (LaBS) - Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy.
Stefano
S
Tagliabue
Department of Chemistry, Materials and Chemical Engineering, Laboratory of Biological Structure Mechanics (LaBS) - Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy.
Erica
E
Rossi
Institute of Materials Physics and Engineering, Department of Applied Science and Technology, Politecnico di Torino, 10129 Torino, Italy. Electronic address: francesco.baino@polito.it.
Francesco
F
Baino
Institute of Materials Physics and Engineering, Department of Applied Science and Technology, Politecnico di Torino, 10129 Torino, Italy. Electronic address: chiara.vitale@polito.it.
Chiara
C
Vitale-Brovarone
Department of Chemistry, Materials and Chemical Engineering, Laboratory of Biological Structure Mechanics (LaBS) - Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy. Electronic address: dario.gastaldi@polimi.it.
Dario
D
Gastaldi
Department of Chemistry, Materials and Chemical Engineering, Laboratory of Biological Structure Mechanics (LaBS) - Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy; I.R.C.C.S., Via R. Galeazzi 4, 20161 Milano, Italy. Electronic address: pasquale.vena@polimi.it.
Pasquale
P
Vena
D002516:Ceramics / Q000032:analysis*; D019245:Compressive Strength; D020342:Finite Element Analysis; D005898:Glass / Q000032:analysis*; D016062:Porosity; D023822:Tissue Engineering; D054457:Tissue Scaffolds; D055114:X-Ray Microtomography
Finite element model; Glass–ceramic; Micro-CT; Porosity; Scaffold