Vitamin D Deficiency Is Associated with Severity of Acute Coronary Syndrome in Patients with Type 2 Diabetes and High Rates of Sun Exposure.
BACKGROUND
Vitamin D deficiency has been associated with cardiovascular risk factors, including type 2 diabetes mellitus (T2DM). Evidence shows that patients with low serum 25-hydroxyvitamin D (25OHD) concentrations have a higher risk of developing coronary artery disease.


OBJECTIVE
The objective of this study was to assess vitamin D as a predictor of the severity in diabetics with acute coronary syndrome (ACS).


METHODS
A total of 166 patients were diagnosed with ACS. Serum 25OHD concentrations were analyzed, and risk factors for ACS were evaluated.


RESULTS
Patients diagnosed as having acute myocardial infarction with elevation of the ST segment had a higher rate of 25OHD, <20 ng/mL compared to ≥30 ng/mL (47.8% × 13.4%, P = 0.03). Diabetics with vitamin D deficiency had more multivessel lesions in the coronary angiography than non-diabetics (69% × 31.8%, P = 0.007). After adjustments for confounders, serum 25OHD remained associated with more severe disease.


CONCLUSIONS
Vitamin D deficiency is associated with more severe ACS and is a predictor of more extensive coronary lesions in patients with T2DM.
Division of Endocrinology, Diabetes and.
Fernando
F
Gondim
Cardiology, Agamenon Magalhães Hospital, University of Pernambuco Medical School, Recife, Brazil.
Ana
A
Caribé
Division of Endocrinology, Diabetes and.
Karine Ferreira
KF
Vasconcelos
Division of Endocrinology, Diabetes and.
Alexandre Dantas
AD
Segundo
Division of Endocrinology, Diabetes and.
Francisco
F
Bandeira
25-hydroxyvitamin D; acute coronary syndrome; type 2 diabetes mellitus