Nanocomposites based on Soluplus and Angelica gigas Nakai extract fabricated by an electrohydrodynamic method for oral administration.
Nanocomposites (NCs) based on Soluplus (SP) were fabricated by an electrohydrodynamic (EHD) method for the oral delivery of Angelica gigas Nakai (AGN). Nano-sized particles were obtained after dispersing the resultant, produced by the EHD technique, in the aqueous environment. AGN/SP2 (AGN:SP=1:2, w/w) NC dispersion in aqueous media exhibited a 130nm mean diameter, narrow size distribution, and robust stability in the tested concentration range of the ethanol extract of AGN (AGN EtOH ext) and at pH 1.2 and 6.8. Amorphization of the components of AGN and their interactions with SP in the AGN/SP2 NC formulation were demonstrated by X-ray diffractometry (XRD) analysis. The released amounts of decursin (D) and decursinol angelate (DA), major components of AGN, from NCs were improved compared with those from the AGN EtOH ext group at both pH 1.2 and 6.8. As D and DA can be metabolized into decursinol (DOH) in the liver after oral administration, the DOH concentrations in plasma were quantitatively determined to evaluate the oral absorption of AGN. In a pharmacokinetic study in rats, higher oral absorption and the maximum concentration in plasma (Cmax) were presented in the AGN/SP2 NC group compared with the AGN EtOH ext and AGN NC groups. These findings indicate the successful application of developed SP-based NCs for the oral delivery of AGN.
College of Pharmacy, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea.
Jeong-Jun
JJ
Lee
College of Pharmacy, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea.
Suyeong
S
Nam
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Ju-Hwan
JH
Park
College of Pharmacy, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea.
Song Yi
SY
Lee
College of Pharmacy, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea.
Jae Young
JY
Jeong
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Jae-Young
JY
Lee
School of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea.
Wie-Soo
WS
Kang
College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam 58554, Republic of Korea.
In-Soo
IS
Yoon
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Dae-Duk
DD
Kim
College of Pharmacy, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea. Electronic address: hjcho@kangwon.ac.kr.
Hyun-Jong
HJ
Cho
D000284:Administration, Oral; D029969:Angelica / Q000737:chemistry*; D000818:Animals; D001578:Benzopyrans / Q000097:blood / Q000302:isolation & purification / Q000493:pharmacokinetics*; D002087:Butyrates / Q000097:blood / Q000302:isolation & purification / Q000493:pharmacokinetics*; D055664:Electrochemical Techniques; D057446:Hydrodynamics; D006863:Hydrogen-Ion Concentration; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
D001578:Benzopyrans; D002087:Butyrates; D010936:Plant Extracts; C101278:decursin
Angelica gigas Nakai; Electrohydrodynamic process; Nanocomposite; Oral absorption; Soluplus