Periocular discoloration after using a prostaglandin analog for eyelash enhancement: evaluation with reflectance confocal microscopy.
A 32-year-old Caucasian woman was admitted to our outpatient department with periocular discoloration. She applied a serum with the active ingredient isopropyl cloprostenate for enhancing the growth of the eyelashes. The discoloration appeared for the first time when the patient had used the serum and gradually remitted after the discontinuation of use. Confocal laser scanning microscopy revealed small white spots in the perifollicular dermis and in the surrounding dilated vessels, which was reported earlier as a side effect of prostaglandin analogs.
Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany.
Orsolya
http://orcid.org/0000-0002-2201-349X
O
N Horváth
Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany.
Valerie
V
Letulé
Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany.
Thomas
T
Ruzicka
Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany.
Thomas
T
Herzinger
Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany.
Ilana
I
Goldscheider
Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany.
Tanja
T
von Braunmühl
D000328:Adult; D005140:Eyelashes / Q000187:drug effects; D005141:Eyelid Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D018613:Microscopy, Confocal; D010859:Pigmentation Disorders / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011453:Prostaglandins / Q000009:adverse effects*; D012880:Skin Pigmentation / Q000187:drug effects*
D011453:Prostaglandins
bimatoprost; eyelash enhancement; isopropyl cloprostenate; periocular hyperpigmentation