The Role of Diffusion-Weighted Imaging in the Evaluation of the Whole Brain in Isolated Unilateral Polymicrogyria.
The aim is to evaluate normal-appearing brain regions in isolated unilateral polymicrogyria patients and compare them with controls by using diffusion-weighted imaging and apparent diffusion coefficient. The diffusion-weighted images (b = 0-1000 s/mm2) of 10 pediatric patients (7 boys, 3 girls; mean age = 5.8 ± 4.3 years) with isolated unilateral polymicrogyria and age-sex matched 10 control patients were assessed retrospectively. There was a significant increase in apparent diffusion coefficient values of white matter underlying polymicrogyria, uninvolved white matter, deep gray matter (thalami, lentiform nuclei, caudate nuclei) and corpus callosum in polymicrogyria patients compared to control group (P < .01). The whole brain might be affected in isolated unilateral polymicrogyria patients. The abnormal deep gray matter in polymicrogyria patients would indicate a new point of view for pediatric neurologists about the probability of additional future neurological disorders.
Radiology, Pediatric Radiology Section, Erciyes University School of Medicine, Kayseri, Turkey drburcugorkem@gmail.com.
Sureyya Burcu
SB
Görkem
Radiology, Pediatric Radiology Section, Erciyes University School of Medicine, Kayseri, Turkey.
Selim
S
Doganay
Biomedical Imaging Research Center, Erciyes University, Kayseri, Turkey.
Kazim
K
Gumus
Pediatric Neurology, Erciyes University School of Medicine, Kayseri, Turkey.
Ayse
A
Bayram
Pediatric Neurology, Erciyes University School of Medicine, Kayseri, Turkey.
Sefer
S
Kumandas
Radiology, Pediatric Radiology Section, Erciyes University School of Medicine, Kayseri, Turkey.
Abdulhakim
A
Coskun
D001921:Brain / Q000000981:diagnostic imaging*; D002648:Child; D002675:Child, Preschool; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D066128:Gray Matter / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D065706:Polymicrogyria / Q000000981:diagnostic imaging*; D012189:Retrospective Studies; D066127:White Matter / Q000000981:diagnostic imaging
apparent diffusion coefficient; children; diffusion-weighted imaging; polymicrogyria