Amphotericin B lipid complex in the treatment of severe paracoccidioidomycosis: a case series.
Amphotericin B deoxycholate is the main option for intravenous (i.v.) treatment of severe paracoccidioidomycosis (PCM). This is the first report of amphotericin B lipid complex (ABLC) in the treatment of PCM. Among 28 patients, cure was achieved in all patients (100%) using ABLC. Mean and median daily doses of ABLC were 3.39 mg/kg/day and 3.35 mg/kg/day, respectively. ABLC may be a choice in the treatment of severe forms of PCM or when i.v. options are required.
Division of Infectious Diseases, Universidade Federal do Espírito Santo, Vitoria, ES, Brazil.
Paulo Mendes
PM
Peçanha
Division of Infectious Diseases, Universidade Federal do Espírito Santo, Vitoria, ES, Brazil.
Stella
S
de Souza
Division of Infectious Diseases, Universidade Federal do Espírito Santo, Vitoria, ES, Brazil.
Aloísio
A
Falqueto
Division of Infectious Diseases, Universidade Federal do Espírito Santo, Vitoria, ES, Brazil.
Tânia Regina
TR
Grão-Veloso
Division of Infectious Diseases, Universidade Federal do Espírito Santo, Vitoria, ES, Brazil.
Ludmila Ventura
LV
Lírio
Division of Infectious Diseases, Universidade Federal do Espírito Santo, Vitoria, ES, Brazil.
Carlos Urbano Gonçalves
CU
Ferreira
Division of Infectious Diseases, Universidade Federal do Espírito Santo, Vitoria, ES, Brazil.
Aline Rocha
AR
Santos
Division of Infectious Diseases, Universidade Federal do Espírito Santo, Vitoria, ES, Brazil.
Hélbia Garcia
HG
Costa
Division of Infectious Diseases, Universidade Federal do Espírito Santo, Vitoria, ES, Brazil.
Lúcia Renata Meirelles
LR
de Souza
Department of Medicine, School of Health and Biosciences, Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brazil; Division of Infectious Diseases, Universidade Federal do Parana, Curitiba, PR, Brazil. Electronic address: flptuon@gmail.com.
Felipe Francisco
FF
Tuon
D000293:Adolescent; D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010229:Paracoccidioidomycosis / Q000188:drug therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
D000935:Antifungal Agents; C068538:liposomal amphotericin B; D000666:Amphotericin B
Amphotericin B; Amphotericin B lipid complex; Liposomal amphotericin B; Paracoccidioides brasiliensis; Paracoccidioidomycosis