Rationale and design of the Randomized Evaluation of patients with Stable angina Comparing Utilization of noninvasive Examinations (RESCUE) trial.
RESCUE is a phase III, randomized, controlled, multicenter, comparative efficacy study, designed to compare two diagnostic imaging/treatment paradigms that use coronary computed tomography angiography (CCTA) or single photon emission computed tomography myocardial perfusion imaging (SPECT MPI) for assisting in the diagnosis of ischemic heart disease in patients with stable angina symptoms, and guiding subsequent treatment. The study is based on the hypothesis that CCTA as a diagnostic tool is associated with no increase in cardiac risk, decreased cost, and reduced radiation exposure compared with SPECT MPI. The RESCUE trial was funded by the Agency for Healthcare Research and Quality (AHRQ) and the American College of Radiology Imaging Network (ACRIN) Fund for Imaging Innovation, began in 2011, and completed in 2014.
Department of Radiology and Imaging Sciences, Emory University, 1365 Clifton Rd NE Atlanta, GA 30322; Division of Cardiology, Emory University, Atlanta GA. Electronic address: aestill@emory.edu.
Arthur E
AE
Stillman
Center for Statistical Sciences, Brown University, Providence RI; Department of Biostatistics, Brown University School of Public Health, Providence RI.
Constantine
C
Gatsonis
Departments of Medicine and Radiology, Johns Hopkins University, Baltimore MD.
João A C
JA
Lima
Department of Radiology, Dartmouth-Hitchcock Medical Center, Lebanon NH.
William C
WC
Black
Center for Statistical Sciences, Brown University, Providence RI.
Jean
J
Cormack
Center for Statistical Sciences, Brown University, Providence RI; Department of Epidemiology, Brown University School of Public Health.
Ilana
I
Gareen
Department of Radiology, Massachusetts General Hospital, Boston MA.
Udo
U
Hoffmann
Center for Statistical Sciences, Brown University, Providence RI; Department of Biostatistics, Brown University School of Public Health, Providence RI.
Tao
T
Liu
Division of Cardiology, Emory University, Atlanta GA.
Kreton
K
Mavromatis
Department of Radiology, University of Pennsylvania, Philadelphia PA.
Mitchell D
MD
Schnall
Division of Cardiology, Tufts-New England Medical Center, Boston MA.
James E
JE
Udelson
Department of Radiology, Mallinckrodt Institute of Radiology, Washington University, St. Louis MO.
Pamela K
PK
Woodard
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D060050:Angina, Stable / Q000000981:diagnostic imaging* / Q000628:therapy; D057911:Angiotensin Receptor Antagonists / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D000072226:Computed Tomography Angiography; D017023:Coronary Angiography; D004035:Diet Therapy; D015444:Exercise; D005260:Female; D006331:Heart Diseases / Q000401:mortality; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging* / Q000628:therapy; D055414:Myocardial Perfusion Imaging; D009204:Myocardial Revascularization / Q000706:statistics & numerical data; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D016540:Smoking Cessation; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon; D014665:Vasodilator Agents / Q000627:therapeutic use
D000319:Adrenergic beta-Antagonists; D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D010975:Platelet Aggregation Inhibitors; D014665:Vasodilator Agents