Genetics of Obesity.
Numerous classical genetic studies have proved that genes are contributory factors for obesity. Genes are directly responsible for obesity associated disorders such as Bardet-Biedl and Prader-Willi syndromes. However, both genes as well as environment are associated with obesity in the general population. Genetic epidemiological approaches, particularly genome-wide association studies, have unraveled many genes which play important roles in human obesity. Elucidation of their biological functions can be very useful for understanding pathobiology of obesity. In the near future, further exploration of obesity genetics may help to develop useful diagnostic and predictive tests for obesity treatment.
Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Rae Bareli Road, Lucknow, Uttar Pradesh 226014 India ; Department of Physiology, King George's Medical University, Chowk, Lucknow, Uttar Pradesh 226003 India.
Apurva
A
Srivastava
Department of Physiology, King George's Medical University, Chowk, Lucknow, Uttar Pradesh 226003 India.
Neena
N
Srivastava
Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Rae Bareli Road, Lucknow, Uttar Pradesh 226014 India.
Balraj
B
Mittal
BMI; Epidemiology; GWAS; Genetics; Obesity