Magnetic Resonance Imaging in Experimental Traumatic Brain Injury.
Traumatic brain injury (TBI) is a leading cause of death and disability in the USA. Common causes of TBI include falls, violence, injuries from wars, and vehicular and sporting accidents. The initial direct mechanical damage in TBI is followed by progressive secondary injuries such as brain swelling, perturbed cerebral blood flow (CBF), abnormal cerebrovascular reactivity (CR), metabolic dysfunction, blood-brain-barrier disruption, inflammation, oxidative stress, and excitotoxicity, among others. Magnetic resonance imaging (MRI) offers the means to noninvasively probe many of these secondary injuries. MRI has been used to image anatomical, physiological, and functional changes associated with TBI in a longitudinal manner. This chapter describes controlled cortical impact (CCI) TBI surgical procedures, a few common MRI protocols used in TBI imaging, and, finally, image analysis pertaining to experimental TBI imaging in rats.
Research Imaging Institute, University of Texas Health Science Center, 8403 Floyd Curl Dr, San Antonio, TX, 78229, USA. shenq3@uthscsa.edu.|Department of Ophthalmology, University of Texas Health Science Center, San Antonio, TX, USA. shenq3@uthscsa.edu.|Department of Radiology, University of Texas Health Science Center, San Antonio, TX, USA. shenq3@uthscsa.edu.
Qiang
Q
Shen
Research Imaging Institute, University of Texas Health Science Center, 8403 Floyd Curl Dr, San Antonio, TX, 78229, USA.|Departments of Cellular and Structure Biology, University of Texas Health Science Center, San Antonio, TX, USA.
Lora Tally
LT
Watts
Research Imaging Institute, University of Texas Health Science Center, 8403 Floyd Curl Dr, San Antonio, TX, 78229, USA.|Department of Ophthalmology, University of Texas Health Science Center, San Antonio, TX, USA.
Wei
W
Li
Research Imaging Institute, University of Texas Health Science Center, 8403 Floyd Curl Dr, San Antonio, TX, 78229, USA. duongt@uthscsa.edu.|Department of Ophthalmology, University of Texas Health Science Center, San Antonio, TX, USA. duongt@uthscsa.edu.|Department of Radiology, University of Texas Health Science Center, San Antonio, TX, USA. duongt@uthscsa.edu.|Department of Veterans Affairs, South Texas Veterans Health Care System, San Antonio, TX, USA. duongt@uthscsa.edu.
Timothy Q
TQ
Duong
D000818:Animals; D000070642:Brain Injuries, Traumatic / Q000175:diagnosis* / Q000209:etiology*; D004195:Disease Models, Animal; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D051381:Rats; D066127:White Matter / Q000000981:diagnostic imaging / Q000473:pathology
ADC; BBB; CBF; DWI; Experimental TBI model; MRI; PWI; Rodents; Traumatic brain injury; fMRI