Uridylation Earmarks mRNAs for Degradation… and More.
Groundbreaking discoveries have uncovered the widespread post-transcriptional modifications of all classes of RNA. These studies have led to the emerging notion of an 'epitranscriptome' as a new layer of gene regulation. Diverse modifications control RNA fate, including the 3' addition of untemplated nucleotides or 3' tailing. The most exciting recent discoveries in 3' tailing are related to uridylation. Uridylation targets various noncoding RNAs, from small RNAs and their precursors to rRNAs, and U tails mostly regulate processing or degradation. Interestingly, uridylation is also a pervasive modification of mRNAs. In this review, we discuss how the addition of few uridines to the 3' end of mRNAs influences mRNA decay. We also consider recent findings that reveal other consequences of uridylation on mRNA fate.
Institut de Biologie Moléculaire des Plantes (IBMP), Centre National de la Recherche Scientifique (CNRS), University of Strasbourg, 67000 Strasbourg, France.
Hélène
H
Scheer
Institut de Biologie Moléculaire des Plantes (IBMP), Centre National de la Recherche Scientifique (CNRS), University of Strasbourg, 67000 Strasbourg, France.
Hélène
H
Zuber
Institut de Biologie Moléculaire des Plantes (IBMP), Centre National de la Recherche Scientifique (CNRS), University of Strasbourg, 67000 Strasbourg, France.
Caroline
C
De Almeida
Institut de Biologie Moléculaire des Plantes (IBMP), Centre National de la Recherche Scientifique (CNRS), University of Strasbourg, 67000 Strasbourg, France. Electronic address: dominique.gagliardi@ibmp-cnrs.unistra.fr.
Dominique
D
Gagliardi
D020413:3' Untranslated Regions / Q000235:genetics; D005786:Gene Expression Regulation / Q000235:genetics; D006801:Humans; D020871:RNA Stability / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics*; D014529:Uridine / Q000235:genetics* / Q000378:metabolism
D020413:3' Untranslated Regions; D012333:RNA, Messenger; D014529:Uridine
deadenylation; degradation; mRNA; translation; uridylation