Mixtures, Metabolites, and Mechanisms: Understanding Toxicology Using Zebrafish.
For more than 60 years, zebrafish have been used in toxicological studies. Due to their transparency, genetic tractability, and compatibility with high-throughput screens, zebrafish embryos are uniquely suited to study the effects of pharmaceuticals and environmental insults on embryonic development, organ formation and function, and reproductive success. This special issue of Zebrafish highlights the ways zebrafish are used to investigate the toxic effects of endocrine disruptors, pesticides, and heavy metals.
1 Department of Reproductive Toxicology, Drug Safety Evaluation, Bristol-Myers Squibb , New Brunswick, New Jersey.
Joshua T
JT
Gamse
2 Department of Pharmacology and Toxicology, University of Alabama at Birmingham , Birmingham, Alabama.
Daniel A
DA
Gorelick
D000818:Animals; D023421:Models, Animal; D014116:Toxicology; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D015027:Zebrafish / Q000196:embryology / Q000378:metabolism*
D014874:Water Pollutants, Chemical