Metabolic and endocrine effects of bisphenol A exposure in market seller women with polycystic ovary syndrome.
Bisphenol A (BPA) is one of the synthetic monomer which can be found in the environment. Limited animal and human studies have demonstrated that BPA alters endocrine and or metabolic functions. The aims of the present study were to evaluate serum BPA level in marketing seller women with polycystic ovary syndrome (PCOS) and hormonal and metabolic effects of this exposure compared to a control paired group. In a case-control study, 62 PCOS women who work as marketing sellers and 62 healthy women with similar jobs were included. The two groups were body mass index (BMI)- and age-matched. Serum samples were analyzed for BPA content, fasting blood sugar (FBS), triglyceride, cholesterol, HDL and LDL levels, thyroid stimulating hormone (TSH) concentration, and LH:FSH ratio. Significant higher serum BPA content (0.48 ± 0.08 vs. 0.16 ± 0.04 ng/ml), triglyceride (103.05 ± 13.10 vs. 91.65 ± 12.52 mg/dl), cholesterol (165.05 ± 10.79 vs. 161.21 ± 10.31 mg/dl) levels and LH:FSH ratio (3.64 ± 0.86 vs. 0.62 ± 0.14) and significant lower TSH concentration (1.56 ± 0.68 vs. 2.15 ± 1.09 IU/ml) were detected in case against control group, respectively (P < 0.05). No significant differences were detected in FBS, LDL, and HDL levels between the two groups. Also, there were no significant associations between serum TSH concentration and BPA level neither in case (P = 0.269) nor in control (P = 0.532) groups. In BPA-exposed PCOS women, BPA level was higher than healthy women and this difference maybe the cause of significant differences in levels of triglyceride, cholesterol, TSH, and LH:FSH ratio. These observations confirm the potential role of BPA in PCOS pathophysiology.
Center of Experimental and Comparative Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Mahjoob
M
Vahedi
Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Arastoo
A
Saeedi
Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Seyedeh Leila
SL
Poorbaghi
Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, PO Box: 71935-1311, Shiraz, Iran. sepehrimaneshmasood@gmail.com.
Masood
http://orcid.org/0000-0002-6300-2906
M
Sepehrimanesh
Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, PO Box: 71935-1311, Shiraz, Iran.
Mohammadreza
M
Fattahi
D000328:Adult; D001559:Benzhydryl Compounds / Q000097:blood / Q000633:toxicity*; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose; D015992:Body Mass Index; D016022:Case-Control Studies; D004785:Environmental Pollutants / Q000097:blood / Q000633:toxicity*; D005260:Female; D006801:Humans; D016273:Occupational Exposure; D010636:Phenols / Q000097:blood / Q000633:toxicity*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000139:chemically induced; D013972:Thyrotropin; D014280:Triglycerides / Q000097:blood; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D015415:Biomarkers; D001786:Blood Glucose; D004785:Environmental Pollutants; D010636:Phenols; D013972:Thyrotropin; D014280:Triglycerides; C006780:bisphenol A; D000098826:Bisphenol A Compounds
Bisphenol A; Lipid profile; Polycystic ovary syndrome; Sellers; Thyroid stimulating hormone