Comparison of CPP-ACP, Tri-Calcium Phosphate and Hydroxyapatite on Remineralization of Artificial Caries Like Lesions on Primary Enamel -An in vitro Study.
OBJECTIVE
To compare CPP-ACP, Tri-calcium phosphate and Hydroxyapatite on remineralization of artificial caries like lesions on primary enamel.


METHODS
Ten extracted Primary molars coated with nail varnish, leaving a window of 2×4 mm on buccal and lingual surface were immersed in demineralizing solution for 96 hours and sectioned longitudinally to obtain 40 sections (4 sections per tooth) and were randomly divided into 4 groups (A to D) n=10; Group A: negative control, Group B: CPP-ACP, Group C: Tri-calcium phosphate, Group D: Hydroxyapatite. Sections were subjected to pH cycling for 10 days and were evaluated by polarized light microscope before and after treatment.


RESULTS
Intra group comparison of demineralization and remineralization was done by paired t-test. One way ANOVA was used for multiple group comparisons followed by post HOC TUKEY'S Test for group wise comparisons. Remineralization was found more with Group D followed by Group B, C and A.


CONCLUSIONS
Hydroxyapatite showed better remineralization when compared to CPP-ACP and Tri-calcium phosphate.
Meghna
M
Bajaj
P
P
Poornima
S
S
Praveen
N B
NB
Nagaveni
K B
KB
Roopa
I E
IE
Neena
K P
KP
Bharath
D002130:Calcium Phosphates / Q000627:therapeutic use*; D002327:Cariostatic Agents / Q000627:therapeutic use*; D002364:Caseins / Q000627:therapeutic use*; D003731:Dental Caries / Q000517:prevention & control*; D003743:Dental Enamel / Q000187:drug effects; D017886:Durapatite / Q000627:therapeutic use*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008422:Materials Testing; D008859:Microscopy, Polarization; D008963:Molar / Q000187:drug effects; D011897:Random Allocation; D012969:Sodium Fluoride / Q000627:therapeutic use; D013997:Time Factors; D017001:Tooth Demineralization / Q000517:prevention & control; D014089:Tooth Remineralization / Q000379:methods*; D014094:Tooth, Deciduous / Q000187:drug effects
D002130:Calcium Phosphates; D002327:Cariostatic Agents; D002364:Caseins; C447032:casein phosphopeptide-amorphous calcium phosphate nanocomplex; D012969:Sodium Fluoride; D017886:Durapatite; C018392:tricalcium phosphate
CPP-ACP; Demineralization; Hydroxyapatite; Polarized light microscopy; Remineralization; Tri-Calcium phosphate