Pharmacogenomics in Pediatric Oncology: Review of Gene-Drug Associations for Clinical Use.
During the 3rd congress of the European Society of Pharmacogenomics and Personalised Therapy (ESPT) in Budapest in 2015, a preliminary meeting was held aimed at establishing a pediatric individualized treatment in oncology and hematology committees. The main purpose was to facilitate the transfer and harmonization of pharmacogenetic testing from research into clinics, to bring together basic and translational research and to educate health professionals throughout Europe. The objective of this review was to provide the attendees of the meeting as well as the larger scientific community an insight into the compiled evidence regarding current pharmacogenomics knowledge in pediatric oncology. This preliminary evaluation will help steer the committee's work and should give the reader an idea at which stage researchers and clinicians are, in terms of personalizing medicine for children with cancer. From the evidence presented here, future recommendations to achieve this goal will also be suggested.
Cansearch Research Laboratory, Geneva University Medical School, Avenue de la Roseraie 64, 1205 Geneva, Switzerland. vid.mlakar@unige.ch.
Vid
V
Mlakar
Cansearch Research Laboratory, Geneva University Medical School, Avenue de la Roseraie 64, 1205 Geneva, Switzerland. patricia.curtis@unige.ch.
Patricia
P
Huezo-Diaz Curtis
Cansearch Research Laboratory, Geneva University Medical School, Avenue de la Roseraie 64, 1205 Geneva, Switzerland. chakradhara.uppugunduri@unige.ch.
Chakradhara Rao
CR
Satyanarayana Uppugunduri
Charles-Bruneau Cancer Center, Centre hospitalier universitaire Sainte-Justine, 4515 Rue de Rouen, Montreal, QC H1V 1H1, Canada. maja.krajinovic@umontreal.ca.|Department of Pediatrics, University of Montreal, 2900 Boulevard Edouard-Montpetit, Montreal, QC H3T 1J4, Canada. maja.krajinovic@umontreal.ca.|Department of Pharmacology, Faculty of Medicine, University of Montreal, 2900 Boulevard Edouard-Montpetit, Montreal, QC H3T 1J4, Canada. maja.krajinovic@umontreal.ca.
Maja
M
Krajinovic
Cansearch Research Laboratory, Geneva University Medical School, Avenue de la Roseraie 64, 1205 Geneva, Switzerland. marc.ansari@hcuge.ch.|Pediatric Department, Onco-Hematology Unit, Geneva University Hospital, Rue Willy-Donzé 6, 1205 Geneva, Switzerland. marc.ansari@hcuge.ch.
Marc
M
Ansari
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002648:Child; D003226:Congresses as Topic; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D008495:Medical Oncology / Q000379:methods*; D010372:Pediatrics / Q000379:methods*; D010597:Pharmacogenetics / Q000379:methods*; D011485:Protein Binding
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors
PharmGKB; cisplatin; cyclophosphamide; irinotecan; methotrexate; pediatrics; pharmacogenomics; thiopurine