Effect of kolaviron, a biflavanoid complex from Garcinia kola on some biochemical parameters in experimentally induced benign prostatic hyperplasic rats.
BACKGROUND
To determine the effect of kolaviron on some biochemical parameters in benign prostatic hyperplasia (BPH) rats.


METHODS
BPH was induced in rats using a mixture of dihydrotestosterone and estradiol valerate (10:1).


RESULTS
The lethal dose of kolaviron was 3050mg/kg body weight. Body weights, relative heart weight (RHW), relative liver weight (RLW), serum levels of prostate specific antigen, prolactin, estradiol, testosterone, testosterone/estradiol ratio, aspartate transaminase (AST), alanine transaminase (ALT), urea, creatinine and prostatic levels of total proteins in the normal rats administered finasteride (standard drug) or kolaviron were not different (P>0.05) from normal control whereas most of these parameters were altered in the disease control except RHW, RLW, AST and ALT. Finasteride (5mg/70kg) or kolaviron (100 and 200mg/kg) ameliorated most of these parameters compared with disease control except RHW, RLW, prolactin, AST, ALT, urea and creatinine (for kolaviron at 100mg/kg). The normal rats administered finasteride or kolaviron had decreased prostate weights (P<0.05) compared with the normal control which results were corroborated by histological assay that also showed that treatment with kolaviron (200mg/kg) or finasteride reversed the histoarchitecture of the prostates of the BPH rats.


CONCLUSIONS
Kolaviron could be useful in the management of BPH.
Department of Biochemistry, Michael Okpara University of Agriculture, Umudike, Nigeria. Electronic address: winnnerkalu@gmail.com.
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Kalu
Department of Biochemistry, Michael Okpara University of Agriculture, Umudike, Nigeria.
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Okafor
Department of Biochemistry, Michael Okpara University of Agriculture, Umudike, Nigeria.
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Ijeh
Federal University, Ndufu-Alike, Ikwo, Ebonyi State, Nigeria.
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Eleazu
D000818:Animals; D013196:Dihydrotestosterone / Q000633:toxicity; D004958:Estradiol / Q000031:analogs & derivatives / Q000633:toxicity; D044950:Flavanones / Q000302:isolation & purification / Q000627:therapeutic use*; D005419:Flavonoids / Q000302:isolation & purification / Q000627:therapeutic use*; D029763:Garcinia kola; D008297:Male; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D011470:Prostatic Hyperplasia / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds
D044950:Flavanones; D005419:Flavonoids; D010936:Plant Extracts; D013196:Dihydrotestosterone; D004958:Estradiol; C045492:kolaviron
Herbal medicine; Hormones; Kolaviron; Prostatic disease