2016 Arte Poster Competition First Place Winner: Circadian Rhythm and UV-Induced Skin Damage: An In Vivo Study.
Exposure of the skin to ultraviolet (UV) irradiation causes many detrimental effects through mechanisms related to oxidative stress and DNA damage. Excessive oxidative stress can cause apoptosis and cellular dysfunction of epidermal cells leading to cellular senescence and connective tissue degradation. Direct and indirect damage to DNA predisposes the skin to cancer formation. Chronic UV exposure also leads to skin aging manifested as wrinkling, loss of skin tone, and decreased resilience. Fortunately, human skin has several natural mechanisms for combating UV-induced damage. The mechanisms operate on a diurnal rhythm, a cycle that repeats approximately every 24 hours. It is known that the circadian rhythm is involved in many skin physiologic processes, including water regulation and epidermal stem cell function. This study evaluated whether UV damage and the skin's natural mechanisms of inflammation and repair are also affected by circadian rhythm. We looked at UV-induced erythema on seven human subjects irradiated with simulated solar radiation in the morning (at 08:00 h) versus in the afternoon (at 16:00 h). Our data suggest that the same dose of UV radiation induces significantly more inflammation in the morning than in the afternoon. Changes in protein expression relevant to DNA damage, such as xeroderma pigmentosum, complementation group A (XPA), and cyclobutane pyrimidine dimers (CPD) from skin biopsies correlated with our clinical results. Both XPA and CPD levels were higher after the morning UV exposure compared with the afternoon exposure. <br /><br /> <em>J Drugs Dermatol.</em> 2016;15(9):1124-1130.
Linna
L
Guan
Amanda
A
Suggs
Sayeeda
S
Ahsanuddin
Madeline
M
Tarrillion
Jacqueline
J
Selph
Minh
M
Lam
Elma
E
Baron
D000818:Animals; D001363:Awards and Prizes; D002940:Circadian Rhythm / Q000502:physiology / Q000528:radiation effects*; D004249:DNA Damage / Q000502:physiology / Q000528:radiation effects*; D004890:Erythema / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D057175:Posters as Topic; D012867:Skin / Q000473:pathology / Q000528:radiation effects*; D014466:Ultraviolet Rays / Q000009:adverse effects*