68Ga-NODAGA-RGDyK PET/CT Imaging in Esophageal Cancer: First-in-Human Imaging.
Ga-NODAGA-RGDyK(cyclic) and FDG PET/CT were performed in a 39-year-old man for the work-up of a moderately differentiated carcinoma of the gastro-esophageal junction within a clinical study protocol. Although FDG PET images showed intense, diffuse hypermetabolic lesion activity, NODAGA-RGDyK illustrated the neo-angiogenesis process with tracer uptake clearly localized in non-FDG-avid perilesional structures. Neo-angiogenesis is characterized by ανβ3 integrin expression at the lesion surface of newly formed vessels. This case supports evidence that angiogenesis imaging might therefore be a crucial step in early disease identification and localization, metastatization potential, and in monitoring the efficacy of antiangiogenic therapies.
From the Departments of *Nuclear Medicine and Molecular Imaging, and †Visceral Surgery, Lausanne University Hospital, Lausanne, Switzerland.
Axel
A
Van Der Gucht
Anastasia
A
Pomoni
Mario
M
Jreige
Pierre
P
Allemann
John O
JO
Prior
D000328:Adult; D002277:Carcinoma / Q000098:blood supply / Q000000981:diagnostic imaging*; D056831:Coordination Complexes; D004938:Esophageal Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging*; D004943:Esophagogastric Junction / Q000098:blood supply / Q000000981:diagnostic imaging*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging*; D010456:Peptides, Cyclic; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals
C561299:68Ga-NODAGA-RGD; D056831:Coordination Complexes; D010456:Peptides, Cyclic; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18