[Human herpes virus 6 infection in an inmunocompetent patient with carbamazepine-induced DRESS syndrome].
DRESS syndrome (drug reaction with eosinophilia and systemic symptoms) is an adverse life-threatening drug reaction characterized by a polymorphous rash associated with fever, lymphadenopathy and multiorgan involvement with eosinophilia. We present the case of an immunocompetent man with DRESS syndrome secondary to carbamazepine, that developed concomitantly meningoencephalitis caused by human herpes virus 6 (HHV-6), and a review of literature. The pathogenic role of HHV-6 in DRESS syndrome remains controversial. Given the diagnostic and possibly prognostic significance of HHV-6, the screening seems to be a good measure to use in the clinical management of these patients.
Departamento de Dermatología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Chile.
Sergio
S
Álvarez
Departamento de Enfermedades Infecciosas del Adulto, Facultad de Medicina, Pontificia Universidad Católica de Chile, Chile.
Ignacio
I
Delama
Departamento de Dermatología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Chile.
Lucas
L
Navajas-Galimany
Departamento de Medicina Interna, Facultad de Medicina, Pontificia Universidad Católica de Chile, Chile.
Gonzalo
G
Eymin
Departamento de Enfermedades Infecciosas del Adulto, Facultad de Medicina, Pontificia Universidad Católica de Chile, Chile.
M Elena
ME
Ceballos
Departamento de Dermatología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Chile, rominaandino@gmail.com.
Romina
R
Andino-Navarrete
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D000998:Antiviral Agents / Q000627:therapeutic use; D002220:Carbamazepine / Q000009:adverse effects*; D063926:Drug Hypersensitivity Syndrome / Q000175:diagnosis / Q000209:etiology*; D015654:Herpesvirus 6, Human / Q000502:physiology*; D006801:Humans; D007121:Immunocompetence; D008297:Male; D008590:Meningoencephalitis / Q000188:drug therapy / Q000276:immunology / Q000821:virology*; D016133:Polymerase Chain Reaction; D014775:Virus Activation
D000927:Anticonvulsants; D000998:Antiviral Agents; D002220:Carbamazepine