Cyclodextrin-polyhydrazine degradable gels for hydrophobic drug delivery.
An injectable and biocompatible hydrogel system was designed for hydrophobic drug delivery. This hydrogel consisted of degradable polymers with cyclodextrin (CD) moieties. CD groups were used to increase the solubility of a hydrophobic molecule (nicardipine) in an aqueous solution through the formation of the inclusion complex. Two sets of gels were prepared by mixing oxidized dextran (DA) and CD functionalized polyhydrazine (PH) at physiological conditions and different level of crosslinking via hydrazone bonds. Cytotoxicity studies on the gels and their components confirmed the biocompatibility of these materials. Gel-30 with higher crosslinking density showed a two week degradation period whereas this period was 10days for gel-10, with lower crosslinking density, to complete degradation. The results from swelling tests and rheological measurements were also found to be dependent on crosslinking density of the hydrogels. Release profile of the hydrogel displayed a sustained release of nicardipin up to 6days for gel-30 and a 4day release with initial burst release for gel-10.
Department of Chemistry, University of Otago, Dunedin 9054, New Zealand.
Esmat
E
Jalalvandi
Department of Chemistry, University of Otago, Dunedin 9054, New Zealand.
Jaydee
J
Cabral
Department of Chemistry, University of Otago, Dunedin 9054, New Zealand.
Lyall R
LR
Hanton
Department of Chemistry, University of Otago, Dunedin 9054, New Zealand. Electronic address: smoratti@chemistry.otago.ac.nz.
Stephen C
SC
Moratti
D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003505:Cyclodextrins / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D065546:Drug Liberation; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D051379:Mice; D009529:Nicardipine / Q000737:chemistry / Q000378:metabolism; D011108:Polymers / Q000737:chemistry; D012212:Rheology
D001672:Biocompatible Materials; D003505:Cyclodextrins; D004337:Drug Carriers; D011108:Polymers; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D009529:Nicardipine
Hydrogel; Hydrophobic drug delivery; Inclusion complex; β-cyclodextrin