A Universal Code for mRNA Stability?
Precise elimination of maternal mRNAs plays a critical role during the maternal-to-zygotic transition (MZT) to promote developmental processing. Two new studies demonstrate that, in eukaryotes, codon-mediated decay is a conserved mechanism to shape maternal mRNA stability by affecting deadenylation rate in a translation-dependent manner. These studies add to a growing body of literature suggesting that translational elongation rates are a major determinant of mRNA stability.
Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, OH, USA.
Ying-Hsin
YH
Chen
Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, OH, USA. Electronic address: jmc71@case.edu.
Jeff
J
Coller
D006801:Humans; D003062:Codon / Q000235:genetics; D056890:Eukaryota / Q000235:genetics; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D014176:Protein Biosynthesis; D020871:RNA Stability / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D015053:Zygote / Q000254:growth & development
D003062:Codon; D012333:RNA, Messenger
codon optimality; deadenylation; mRNA decay; maternal-to-zygotic transition; translation