Polydopamine-Assisted Surface Modification for Bone Biosubstitutes.
Polydopamine (PDA) prepared in the form of a layer of polymerized dopamine (DA) in a weak alkaline solution has been used as a versatile biomimetic surface modifier as well as a broadly used immobilizing macromolecule. This review mainly discusses the progress of biomaterial surface modification inspired by the participation of PDA in bone tissue engineering. A comparison between PDA-assisted coating techniques and traditional surface modification applied to bone tissue engineering is first presented. Secondly, the chemical composition and the underlying formation mechanism of PDA coating layer as a unique surface modifier are interpreted and discussed. Furthermore, several typical examples are provided to evidence the importance of PDA-assisted coating techniques in the construction of bone biosubstitutes and the improvement of material biocompatibility. Nowadays, the application of PDA as a superior surface modifier in multifunctional biomaterials is drawing tremendous interests in bone tissue scaffolds to promote the osteointegration for bone regeneration.
Department of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Shishu
0000-0002-5465-4478
S
Huang
Centre for Human Tissues and Organs Degeneration and Shenzhen Key Laboratory of Marine Biomedical Materials, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China.
Nuanyi
0000-0002-6802-5015
N
Liang
Centre for Human Tissues and Organs Degeneration and Shenzhen Key Laboratory of Marine Biomedical Materials, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China; Fiber and Biopolymer Research Institute, Department of Plant and Soil Science, Texas Tech University, Lubbock, TX 79409, USA.
Yang
0000-0003-3839-4095
Y
Hu
Centre for Human Tissues and Organs Degeneration and Shenzhen Key Laboratory of Marine Biomedical Materials, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China.
Xin
X
Zhou
Fiber and Biopolymer Research Institute, Department of Plant and Soil Science, Texas Tech University, Lubbock, TX 79409, USA.
Noureddine
0000-0001-5642-6332
N
Abidi
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D032701:Biomimetics; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000737:chemistry*; D020099:Coated Materials, Biocompatible; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D051379:Mice; D010012:Osteogenesis; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties; D023822:Tissue Engineering / Q000379:methods*
D001672:Biocompatible Materials; D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D007211:Indoles; D011108:Polymers; C568283:polydopamine