Near-Infrared Light-Driven Photoelectrochemical Aptasensor Based on the Upconversion Nanoparticles and TiO2/CdTe Heterostructure for Detection of Cancer Cells.
A near-infrared-driven photoelectrochemical aptasensor was developed as a new method for the detection of the breast cancer cell MCF-7. The upconversion nanoparticles and TiO2/CdTe heterostructure were combined to prepare the film electrode, and the high-affinity aptamer AS1411 was conjugated to the electrode to recognize MCF-7 cells. In this fabrication, the upconversion nanoparticles transferred the near-infrared light to visible light, which could excite the semiconductor to enhance the current response. As a result, the aptasensor revealed good sensitivity and specificity with MCF-7 cell concentrations ranging from 1 × 103to 1 × 105cells/mL. The results presented a favorable determination of MCF-7 cells, which was achieved with the help of the upconversion nanoparticles and the photoelectrochemical interface.
Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences , Suzhou 215123, China.
Kewei
K
Wang
Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences , Suzhou 215123, China.|School of Pharmacy, Xi'an Jiaotong University , Xi'an 710061, China.
Ruihua
R
Zhang
Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences , Suzhou 215123, China.
Na
N
Sun
Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences , Suzhou 215123, China.|School of Pharmacy, Xi'an Jiaotong University , Xi'an 710061, China.
Xinpan
X
Li
Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences , Suzhou 215123, China.
Jine
J
Wang
Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences , Suzhou 215123, China.
Yi
Y
Cao
Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences , Suzhou 215123, China.
Renjun
R
Pei
D052157:Aptamers, Nucleotide; D015374:Biosensing Techniques; D019187:Cadmium Compounds; D006801:Humans; D061986:MCF-7 Cells; D053758:Nanoparticles; D055668:Photochemical Processes; D013691:Tellurium; D014025:Titanium
D052157:Aptamers, Nucleotide; D019187:Cadmium Compounds; C009495:titanium dioxide; D014025:Titanium; D013691:Tellurium; C028337:cadmium telluride
TiO2/CdTe heterostructure; aptamer; cancer cells; photoelectrochemical aptasensor; upconversion nanoparticles