Effect of hormonal contraceptives on serum lipids: A prospective study.
To estimate the effects of using hormonal contraceptives on serum lipoprotein levels. Lipid profile was measured at baseline and afterward at 3, 6, 9 and 12 months. 1391 Pakistani females taking COCs, DMPA, or non hormonal (NH) contraceptives. The results were calculated by repeated measure ANOVA subsequent to tukey's post hoc test for the multiple comparisons. Statistical examination revealed that differences in lipid profile were significant (p <0.001) among all treated group in comparison with control. DMPA also caused significant rise in Castelli index-I and Castelli index-II as compared to COCs group and control group. This study demonstrated raise in total cholesterol (TC) and triglycerides (TG) as well as very low density lipoprotein (VLDL-C) and low density lipoprotein cholesterol (LDL-C). Whereas, an obvious decrease was observed in high density-lipoprotein cholesterol (HDL-C) in the DMPA-treated group. We concluded that, this inductive study specifies atherogenic cardiovascular risk in women using DMPA on long term basis.
Faculty of Pharmacy, University of Karachi, Pakistan / Faculty of Pharmacy, Jinnah University for Women Karachi, Pakistan.
Huma
H
Dilshad
Faculty of Pharmacy, University of Karachi, Pakistan.
Rabia
R
Ismail
Faculty of Pharmacy, University of Karachi, Pakistan / Faculty of Pharmacy, Jinnah University for Women Karachi, Pakistan.
Safila
S
Naveed
Faculty of Pharmacy, Jinnah University for Women Karachi, Pakistan.
Khan
K
Usmanghani
Faculty of Pharmacy, Jinnah University for Women Karachi, Pakistan.
M Tanweer
MT
Alam
Faculty of Pharmacy, Jinnah University for Women Karachi, Pakistan.
Ghulam
G
Sarwar
D000328:Adult; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008525:Medroxyprogesterone / Q000009:adverse effects; D008875:Middle Aged; D011446:Prospective Studies; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D003278:Contraceptives, Oral, Hormonal; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol; D008525:Medroxyprogesterone