Leptospiral Uveitis: Usefulness of Clinical Signs as Diagnostic Predictors.
OBJECTIVE
To analyze the diagnostic predictive ability of clinical variables.


METHODS
Demographic and clinical variables of 172 serologically proven leptospiral uveitis patients were compared with 200 controls of non-leptospiral uveitis. Multiple logistic regression analysis identified diagnostic predictors. A receiver operating characteristic curve tested the performance of the model.


RESULTS
Of all variables, male gender, farming as an occupation, and clinical features such as non-granulomatous panuveitis, hypopyon, and vitreous infiltration in the absence of retinochoroiditis constituted the predictive parameters, with the sensitivity and specificity of 86% and 90.7%, respectively.


CONCLUSIONS
Multiple logistic analysis detected clinically diagnostic predictors that can assist primary care ophthalmologists. Clinical diagnosis can further be confirmed by serology at tertiary care centers.
a Aravind Eye Hospital , Biostatistics , Madurai , India.
Rathinam
R
Sivakumar
a Aravind Eye Hospital , Biostatistics , Madurai , India.
Vijayakumar
V
Balakrishnan
b Aravind Medical Research Foundation , Madurai , India.
Priya
P
Gowri
c Christian Medical College and Hospital Vellore , Department of Biostatistics , Vellore , India.
Jeyaseelan
J
Visalakshi
D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis; D015818:Eye Infections, Bacterial / Q000175:diagnosis / Q000382:microbiology; D005260:Female; D006801:Humans; D007919:Leptospira / Q000276:immunology / Q000302:isolation & purification; D007922:Leptospirosis / Q000175:diagnosis* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D014605:Uveitis / Q000175:diagnosis* / Q000382:microbiology; D055815:Young Adult
D000907:Antibodies, Bacterial
Diagnostic predictors; leptospirosis; sensitivity; specificity; uveitis