Evaluation of the effect of compression therapy using surgical gloves on nanoparticle albumin-bound paclitaxel-induced peripheral neuropathy: a phase II multicenter study by the Kamigata Breast Cancer Study Group.
To investigate the efficacy of using surgical glove (SG) compression therapy to prevent nanoparticle albumin-bound paclitaxel (nab-PTX)-induced peripheral neuropathy.



Patients with primary and recurrent breast cancer who received 260 mg/m2of nab-PTX were eligible for this case-control study. Patients wore two SGs of the same size, i.e., one size smaller than the size that fit their dominant hand, for only 90 min. They did not wear two SGs on the non-dominant hand, which served as the control hand. Peripheral neuropathy was evaluated at each treatment cycle using common terminology criteria for adverse events (CTCAE) version 4.0 and the Patient Neurotoxicity Questionnaire. The temperature of each fingertip of the compression SG-protected hand and control hand was measured using thermography.



Between August 2013 and January 2016, 43 patients were enrolled and 42 were evaluated. The occurrence rates of CTCAE grade 2 or higher sensory and motor peripheral neuropathies were significantly lower for SG-protected hands than for control hands (sensory neuropathy 21.4 vs. 76.1 %; motor neuropathy 26.2 vs. 57.1 %). No patients withdrew from this study because they could not tolerate the compression from the SGs. SG compression therapy significantly decreased the temperature of each fingertip by 1.6-2.2 °C as compared with the temperature before chemotherapy (p < 0.0001).



SG compression therapy is effective for reducing nab-PTX-induced peripheral neuropathy. The nab-PTX exposure to the peripheral nerve may be decreased because the SG decreases microvascular flow to the fingertip.
Department of Breast Surgery, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, Osaka, 543-8555, Japan. tyksgr@osaka-med.jrc.or.jp.
Shigeru
S
Tsuyuki
Department of Breast Surgery, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, Osaka, 543-8555, Japan.
Noriko
N
Senda
Department of Breast Surgery, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, Osaka, 543-8555, Japan.
Yookija
Y
Kanng
Department of Breast Surgery, Graduate School of Medicine, Kyoto University, 54 Kawaharacho Shogoin, Sakyo-ku, Kyoto, Japan.
Ayane
A
Yamaguchi
Department of Breast Surgery, Japanese Red Cross Society Wakayama Medical Center, 4-20, Komatsubara, Wakayama, Japan.
Hiroshi
H
Yoshibayashi
Department of Breast Surgery, Kobe City Medical Center West Hospital, 2-4, Ichiban-cho, Nagata-ku, Kobe, Japan.|Department of Breast Surgery, Kobe City Medical Center Central Hospital, 2-1-1, Minatojima, Minamimachi, Chuo-ku, Kobe, Japan.
Yuichiro
Y
Kikawa
Department of Integrated Oncology, Institute of Biomedical Research and Innovation Hospital, 2-2, Minatojima Minamimachi, Chuo-ku, Kobe, Japan.
Nobuyuki
N
Katakami
Department of Breast Surgery, Kobe City Medical Center Central Hospital, 2-1-1, Minatojima, Minamimachi, Chuo-ku, Kobe, Japan.
Hironori
H
Kato
Hashimoto Clinic, 1-7-2, Sumimoto Honnmati, Nada-ku, Kobe, Japan.
Takashi
T
Hashimoto
Department of Breast Surgery, Nishi-Kobe Medical Center, 5-7-1, Kojidai, Nishi-ku, Kobe, Japan.
Toshitaka
T
Okuno
Department of Breast Surgery, Tazuke Kofukai Medical Research Institute, Kitano Hospital, 2-4-20, Ohgimachi, Kita-ku, Osaka, Japan.
Akira
A
Yamauchi
Department of Breast Surgery, Tazuke Kofukai Medical Research Institute, Kitano Hospital, 2-4-20, Ohgimachi, Kita-ku, Osaka, Japan.|Department of Nursing Science, Tenri Health Care University, 80-1, Besho-cho, Tenri-city, Nara, Japan.
Takashi
T
Inamoto
D000328:Adult; D000368:Aged; D000068196:Albumin-Bound Paclitaxel / Q000009:adverse effects* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000150:complications* / Q000188:drug therapy; D058128:Compression Bandages; D005260:Female; D005932:Gloves, Surgical; D006801:Humans; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control / Q000628:therapy*; D059825:Physical Therapists; D013817:Thermography; D016896:Treatment Outcome
D000068196:Albumin-Bound Paclitaxel; D000970:Antineoplastic Agents
Compression therapy; Nab-paclitaxel; Peripheral neuropathy; Surgical glove