Asnovolins A-G, Spiromeroterpenoids Isolated from the Fungus Aspergillus novofumigatus, and Suppression of Fibronectin Expression by Asnovolin E.
Seven novel spiromeroterpenoids, asnovolins A-G (1-7), one of which was shown to suppress fibronectin expression, were isolated from Aspergillus novofumigatus CBS117520 along with a known compound, novofumigatonin (8). The structures of asnovolins A-G were elucidated using MS and 2D-NMR data. Asnovolin E (5) suppressed fibronectin expression by normal human neonatal dermal fibroblast cells.
Department of Organic Chemistry, Hoshi University , 2-4-41 Ebara, Shinagawa, Tokyo, Japan.
Kazuki
K
Ishikawa
Department of Organic Chemistry, Hoshi University , 2-4-41 Ebara, Shinagawa, Tokyo, Japan.
Fumiaki
F
Sato
Department of Organic Chemistry, Hoshi University , 2-4-41 Ebara, Shinagawa, Tokyo, Japan.
Takeshi
T
Itabashi
Department of Organic Chemistry, Hoshi University , 2-4-41 Ebara, Shinagawa, Tokyo, Japan.
Hiroshi
H
Wachi
Department of Organic Chemistry, Hoshi University , 2-4-41 Ebara, Shinagawa, Tokyo, Japan.
Hisashi
H
Takeda
Department of Organic Chemistry, Hoshi University , 2-4-41 Ebara, Shinagawa, Tokyo, Japan.
Daigo
D
Wakana
Medical Mycology Research Center (MMRC), Chiba University , 1-8-1 Inohama, Chuo-ku, Chiba, Japan.
Takashi
T
Yaguchi
Department of Organic Chemistry, Hoshi University , 2-4-41 Ebara, Shinagawa, Tokyo, Japan.
Ken-Ichi
K
Kawai
Department of Organic Chemistry, Hoshi University , 2-4-41 Ebara, Shinagawa, Tokyo, Japan.
Tomoo
T
Hosoe
D001230:Aspergillus / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D005353:Fibronectins; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
C067625:FN1 protein, human; D005353:Fibronectins; D013141:Spiro Compounds; D013729:Terpenes; C000620735:asnovolin E; C527912:novofumigatonin