Cytotoxicities of two new isoflavanes from the roots of Dalbergia velutina.
Two new isoflavanes, dalvelutinanes A (1) and B (2), along with three known isoflavanes (3-5) were isolated from the roots of Dalbergia velutina. Their chemical structures, including their absolute configurations, were determined by spectroscopic analysis (1D and 2D NMR, HRESIMS, and CD). All isolated compounds were evaluated for their in vitro cytotoxicities against five human cancer cell lines (KB, HeLa-S3, MCF-7, HepG-2, and HT-29). Compound 5 showed significant cytotoxicity against all of the tested cancer cell lines, with IC50values in the range 3.47-9.76 µM. In addition, compound 3 showed significant cytotoxicity against the KB and HeLa-S3 cells, with IC50values of 8.29 and 9.54 µM, respectively, and compound 2 showed significant cytotoxicity against the MCF-7 cell line, with an IC50value of 4.69 µM.
Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Sutin
S
Kaennakam
Natural Products Research Section, Research Division, National Cancer Institute, Bangkok, 10400, Thailand.
Pongpun
P
Siripong
Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand. Santi.Ti@chula.ac.th.
Santi
S
Tip-Pyang
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D035782:Dalbergia / Q000737:chemistry*; D006801:Humans; D007529:Isoflavones / Q000737:chemistry*; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D007529:Isoflavones
Cytotoxicity; Dalbergia velutina; Dalvelutinanes A and B; Isoflavanes