Midline (Central) Fluid Percussion Model of Traumatic Brain Injury.
Research models of traumatic brain injury (TBI) hold significant validity towards the human condition, with each model replicating a subset of clinical features and symptoms. After 30 years of characterization and implementation, fluid percussion injury (FPI) is firmly recognized as a clinically relevant model of TBI, encompassing concussion through severe injury. The midline variation of FPI may best represent mild and diffuse clinical brain injury, because of the acute behavioral deficits, the late onset of subtle behavioral morbidities, and the absence of gross histopathology. This chapter outlines the procedures for midline (diffuse) FPI in adult male rats and mice. With these procedures, it becomes possible to generate brain-injured laboratory animals for studies of injury-induced pathophysiology and behavioral deficits, for which rational therapeutic interventions can be implemented.
BARROW Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ, 85016, USA.|Department of Child Health, University of Arizona College of Medicine - Phoenix, Phoenix, 85004, AZ, USA.|Phoenix Veteran Affairs Healthcare System, Phoenix, AZ, USA.
Rachel K
RK
Rowe
BARROW Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ, 85016, USA.|Department of Child Health, University of Arizona College of Medicine - Phoenix, Phoenix, 85004, AZ, USA.
Daniel R
DR
Griffiths
BARROW Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ, 85016, USA. jlifshitz@email.arizona.edu.|Department of Child Health, University of Arizona College of Medicine - Phoenix, Phoenix, 85004, AZ, USA. jlifshitz@email.arizona.edu.|Phoenix Veteran Affairs Healthcare System, Phoenix, AZ, USA. jlifshitz@email.arizona.edu.
Jonathan
J
Lifshitz
D000818:Animals; D001924:Brain Concussion / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D000070642:Brain Injuries, Traumatic / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D019635:Neurosurgical Procedures / Q000295:instrumentation / Q000379:methods; D010474:Percussion / Q000009:adverse effects*; D011182:Postoperative Care; D051381:Rats; D012377:Rodentia
Concussion; Diffuse; Experimental model; Fencing response; Fluid percussion; Mouse; Postoperative care; Rat; Righting reflex; Rodent; Trauma; Traumatic brain injury (TBI)