A comprehensive study of oxidative stress in sudden hearing loss.
Little is known about the association between idiopathic sudden sensorineural hearing loss (ISSNHL) and oxidative stress. We investigated changes in a wide range of oxidants and antioxidants to create a comprehensive picture of oxidative imbalance. In the peripheral blood of 50 ISSNHL patients and 50 healthy subjects, total oxidant status (TOS), total antioxidant status (TAS), paraoxonase (PON), thiol/disulphide levels were measured. Moreover, a global oxidative stress index, reflecting both oxidative and antioxidant counterparts, was also calculated. One-way analysis between oxidative markers and severity of hearing loss were evaluated. The ISSNHL patients showed significantly higher TOS levels than controls (6.02 ± 3.17 vs. 4.5 ± 2.22; p = 0.018). The oxidative index was also significantly higher in patients than controls (0.39 ± 0.19 vs. 0.3 ± 0.14; p = 0.035). TAS, PON, native thiol, and total thiol were not altered. There was no statistical significance between oxidative markers and severity of hearing loss. The binary logistic regression model revealed that disulphide and TOS were associated with ISSNHL. There are alterations in a wide array of oxidants and antioxidants, with balance shifting toward increased oxidative stress in ISSNHL. Our findings may suggest endothelial dysfunction in ISSNHL etiopathogenesis.
Department of Otorhinolaryngology, Head and Neck Surgery, Bitlis Tatvan State Hospital, Tatvan, Bitlis, Turkey. drfatihgul@gmail.com.
Fatih
http://orcid.org/0000-0001-7992-0974
F
Gul
Department of Otorhinolaryngology, Head and Neck Surgery, Ataturk Training and Research Hospital, Ankara, Turkey.
Togay
T
Muderris
Department of Otorhinolaryngology, Head and Neck Surgery, Ataturk Training and Research Hospital, Ankara, Turkey.
Gokhan
G
Yalciner
Department of Otorhinolaryngology, Head and Neck Surgery, Karaman State Hospital, Karaman, Turkey.
Ergun
E
Sevil
Department of Otorhinolaryngology, Head and Neck Surgery, Yildirim Beyazit University School of Medicine, Ankara, Turkey.
Sami
S
Bercin
Department of Clinical Biochemistry, Gaziantep 25 Aralık State Hospital, Gaziantep, Turkey.
Merve
M
Ergin
Department of Otorhinolaryngology, Head and Neck Surgery, Yildirim Beyazit University School of Medicine, Ankara, Turkey.
Mehmet Ali
MA
Babademez
Department of Otorhinolaryngology, Head and Neck Surgery, Yildirim Beyazit University School of Medicine, Ankara, Turkey.
Muzaffer
M
Kiris
D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003907:Dexamethasone / Q000627:therapeutic use; D004220:Disulfides / Q000097:blood; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use; D005938:Glucocorticoids; D006319:Hearing Loss, Sensorineural / Q000209:etiology* / Q000628:therapy; D003639:Hearing Loss, Sudden / Q000209:etiology* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000097:blood; D018384:Oxidative Stress; D010431:Pentoxifylline / Q000627:therapeutic use; D013831:Thiamine / Q000627:therapeutic use; D025101:Vitamin B 6 / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use
D015415:Biomarkers; D004220:Disulfides; D016166:Free Radical Scavengers; D005938:Glucocorticoids; D016877:Oxidants; D014815:Vitamins; D003907:Dexamethasone; D025101:Vitamin B 6; D010431:Pentoxifylline; D013831:Thiamine
Oxidative stress; Paraoxonase; Sudden sensorineural hearing loss; Thiol/disulphide homeostasis; Total antioxidant status; Total oxidant status