Polyaniline-coated upconversion nanoparticles with upconverting luminescent and photothermal conversion properties for photothermal cancer therapy.
In this study, we developed a nanosystem based on upconversion nanoparticles (UCNPs) coated with a layer of polyaniline nanoparticles (PANPs). The UCNP induces upconversion luminescence for imaging and photothermal conversion properties are due to PANPs. In vitro experiments showed that the UCNPs-PANPs were nontoxic to cells even at a high concentration (800 µg mL(-1)). Blood analysis and histological experiments demonstrated that the UCNPs-PANPs exhibited no apparent toxicity in mice in vivo. Besides their efficacy in photothermal cancer cell ablation, the UCNP-PANP nanosystem was found to achieve an effective in vivo tumor ablation effect after irradiation using an 808 nm laser. These results demonstrate the potential of the hybrid nanocomposites for use in imaging-guided photothermal therapy.
Department of Chemistry, Renmin University of China, Beijing, People's Republic of China.
Yadong
Y
Xing
Department of Chemistry, Renmin University of China, Beijing, People's Republic of China.
Luoyuan
L
Li
Department of Chemistry, Renmin University of China, Beijing, People's Republic of China.
Xicheng
X
Ai
Department of Chemistry, Renmin University of China, Beijing, People's Republic of China.
Limin
L
Fu
D000814:Aniline Compounds / Q000494:pharmacology*; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D003110:Colonic Neoplasms / Q000473:pathology / Q000628:therapy*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D049449:Luminescence; D008297:Male; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D010789:Phototherapy / Q000379:methods*; D014407:Tumor Cells, Cultured; D023041:Xenograft Model Antitumor Assays
D000814:Aniline Compounds; C416807:polyaniline
photothermal therapy; polyaniline; upconversion luminescence; upconversion nanoparticles