Synthesis and Antiviral Activity Evaluation of Nitroporphyrins and Nitrocorroles as Potential Agents against Human Cytomegalovirus Infection.
Different nitroporphyrinoid derivatives were synthesized and studied as potential agents against human Cytomegalovirus. Interestingly, two nitrocorroles display strong activity against human Cytomegalovirus with IC 50 < 0.5 μM. These compounds also possess antiproliferative activities without detected in vivo toxicity. Therefore, nitrocorroles appear for the first time as potential active compounds that can be applied in human health.
ICMUB (UMR CNRS 6302), Université de Bourgogne Franche-Comté , 9 Avenue Alain Savary, B.P. 47 870, 21078 Dijon Cedex, France.
Claude P
CP
Gros
ICMUB (UMR CNRS 6302), Université de Bourgogne Franche-Comté , 9 Avenue Alain Savary, B.P. 47 870, 21078 Dijon Cedex, France.
Nicolas
N
Desbois
ICMUB (UMR CNRS 6302), Université de Bourgogne Franche-Comté , 9 Avenue Alain Savary, B.P. 47 870, 21078 Dijon Cedex, France.
Clément
C
Michelin
Institut des Technologies Avancées en Sciences du Vivant (CNRS USR3505), 1 place Pierre Potier, Oncopole, entrée B, 31106 Toulouse, France.
Eloise
E
Demilly
INSERM U1037, Centre de Recherche en Cancérologie de Toulouse, 2 avenue Hubert Curien, Oncopole, 31037 Toulouse, France.
Anne-Françoise
AF
Tilkin-Mariamé
Institut des Technologies Avancées en Sciences du Vivant (CNRS USR3505), 1 place Pierre Potier, Oncopole, entrée B, 31106 Toulouse, France.
Bernard
B
Mariamé
Institut des Technologies Avancées en Sciences du Vivant (CNRS USR3505), 1 place Pierre Potier, Oncopole, entrée B, 31106 Toulouse, France.
Franck
F
Gallardo
antiproliferative activities; human Cytomegalovirus; in vivo toxicity; nitrocorroles; nitroporphyrins