[Role of radiotherapy in the treatment of NK/T-cell nasal type and primary cerebral lymphomas].
The head and neck are common sites for extranodal non-Hodgkin lymphomas. Radiotherapy plays an important role in the treatment of low-grade lymphomas, with curative or palliative intent. In the case of high-grade lymphomas, its combination with chemotherapy is debated. Its role is however undeniable in two specific entities: NK/T-cell lymphoma NK/T nasal type, and primary central nervous system lymphomas, which are the subject of this review.
Département d'oncologie radiothérapie, Gustave-Roussy, 114, rue Édouard-Vaillant, 94805 Villejuif cedex, France; Université Paris Saclay, 15, rue Georges-Clemenceau, 91400 Orsay, France.
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A
Boros
Université Paris Saclay, 15, rue Georges-Clemenceau, 91400 Orsay, France; Département d'innovation thérapeutique et d'essais précoces, Gustave-Roussy, 114, rue Édouard-Vaillant, 94805 Villejuif cedex, France.
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JM
Michot
Département de neurologie, division Mazarin, centre hospitalier universitaire Pitié-Salpêtrière, 47-83, boulevard de l'Hôpital, 75013 Paris, France; Université Pierre-et-Marie-Curie, 4, place Jussieu, 75005 Paris, France; Institut du cerveau et de la moelle, CNRS UMR 7225, Inserm U 1127, 47-83, boulevard de l'Hôpital, 75013 Paris, France; Réseau lymphomes oculocérébraux (LOC), 47-83, boulevard de l'Hôpital, 75013 Paris, France.
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K
Hoang-Xuan
Département d'oncologie radiothérapie, Gustave-Roussy, 114, rue Édouard-Vaillant, 94805 Villejuif cedex, France; Université Paris Saclay, 15, rue Georges-Clemenceau, 91400 Orsay, France. Electronic address: renaud.mazeron@gustaveroussy.fr.
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Mazeron
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D003704:Dementia / Q000209:etiology; D006801:Humans; D008223:Lymphoma / Q000628:therapy*; D054391:Lymphoma, Extranodal NK-T-Cell / Q000628:therapy*; D008727:Methotrexate / Q000627:therapeutic use; D009364:Neoplasm Recurrence, Local; D009669:Nose Neoplasms / Q000628:therapy*; D011379:Prognosis; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D033581:Stem Cell Transplantation
D000970:Antineoplastic Agents; D008727:Methotrexate
Chemoradiotherapy; Chimioradiothérapie; High-dose methotrexate; Lymphome NK/T de type nasal; Lymphome cérébral primitif; Méthotrexate haute dose; NK/T-cell lymphoma nasal type; Primary CNS lymphoma; Radiotherapy; Radiothérapie