TNF-α -308 G > A (rs1800629) Polymorphism is Associated with Celiac Disease: A Meta-analysis of 11 Case-Control Studies.
Celiac disease (CD) remains one of the most significant autoimmune diseases worldwide. The pathogenesis of CD is not clearly understood and is probably attributed to genomic variations and host genetic make-up. Case-control and cohort studies of the association between the TNF-α -308 G > A (rs1800629) polymorphism and CD susceptibility have yielded inconsistent results. In this study, PubMed, EMBASE, and Google Scholar web-databases were searched for pertinent reports showing association of TNF-α -308 G > A gene with CD risk. A total of eleven reports involving 1774 controls and 1147 CD cases were included. Significant associations in four genetic models, viz. variant allele (A vs. G: p = 0.001; OR = 2.051, 95% CI = 1.452-2.895), variant homozygous (AA vs. GG: p = 0.001; OR = 6.626, 95% CI = 3.569-12.300), recessive (AA vs. GG + AG: p = 0.001; OR = 4.766, 95% CI = 3.177-7.152) and dominant (AA + AG vs. GG: p = 0.008; OR = 1.910, 95% CI = 1.181-3.088) were found in comparison with wild type homozygous GG genotype. However, heterozygous genetic model did not show any association. Sensitivity analysis revealed stable and statistically robust results. Our results suggest that TNF-α -308 G > A gene polymorphism significantly contributes to CD susceptibility.
Department of Clinical Nutrition, College of Applied Medical Sciences, University of Ha'il, Ha'il-2440, Saudi Arabia.
Saif
S
Khan
Research and Scientific Studies Unit, College of Nursing &Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia.
Raju K
RK
Mandal
Research and Scientific Studies Unit, College of Nursing &Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia.
Arshad
A
Jawed
Research and Scientific Studies Unit, College of Nursing &Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia.|The University College of Medical Sciences &GTB Hospital (University of Delhi), Delhi-110095, India.
Sajad A
SA
Dar
Research and Scientific Studies Unit, College of Nursing &Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia.|Department of Biosciences, Faculty of Natural Sciences, Jamia Millia Islamia (A Central University), New Delhi-110025, India.
Mohd
M
Wahid
Centre for Life Sciences, Central University of Jharkhand, Brambe, Ranchi-835205, Jharkhand, India.
Aditya K
AK
Panda
Research and Scientific Studies Unit, College of Nursing &Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia.
Mohammed Y
MY
Areeshi
Centre for Life Sciences, Central University of Jharkhand, Brambe, Ranchi-835205, Jharkhand, India.
Md Ekhlaque
ME
Ahmed Khan
Research and Scientific Studies Unit, College of Nursing &Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia.|Department of Biosciences, Faculty of Natural Sciences, Jamia Millia Islamia (A Central University), New Delhi-110025, India.
Shafiul
S
Haque
D016022:Case-Control Studies; D002446:Celiac Disease / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D014409:Tumor Necrosis Factor-alpha