[Role of HIF-induced EMT in invasion and metastasis of tumor].
Hypoxia plays a vital role in tumor metabolism, proliferation, apoptosis, invasion and metastasis via hypoxia-inducible factor (HIF). Epithelial to mesenchymal transition (EMT) is a crucial process to metastasis, which could be triggered by hypoxia. EMT could be regulated by HIF via multiple pathways including TGF-β, Notch, and Wnt/β-catenin. It has been shown that anti-HIF drugs combined with anti-EMT therapies could be a promising strategy for tumor therapy.
Department of Medical Oncology 2, Chinese PLA General Hospital, Beijing 100853, China.
Yang
Y
Chen
Department of Medical Oncology 2, Chinese PLA General Hospital, Beijing 100853, China.
Yan
Y
Shi
Department of Medical Oncology 2, Chinese PLA General Hospital, Beijing 100853, China.
Guanghai
G
Dai
D051792:Basic Helix-Loop-Helix Proteins; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms; D016212:Transforming Growth Factor beta; D051176:beta Catenin
D051792:Basic Helix-Loop-Helix Proteins; D016212:Transforming Growth Factor beta; D051176:beta Catenin; C495270:CTNNB1 protein, human