Risk factors for the severity and mortality of pneumococcal pneumonia: Importance of premorbid patients' performance status.
Comorbidity is known to be associated with the severity and mortality of pneumonia. The severity of each underlying disease varies, and performance status, which is known to be a prognostic factor of malignant diseases, reflects the overall patient condition as affected by his/her comorbidity and underlying diseases of various severity. We investigated whether premorbid patients' performance status is associated with the severity and mortality of pneumococcal pneumonia. This retrospective study assessed these factors in hospitalized patients suffering from pneumococcal pneumonia from 2002 to 2015. We included 424 patients aged 68.9 ± 14.1 years in the study, of which 68.9% were men. A multivariate analysis found that advanced age (≥65 years), diabetes mellitus, and poor performance status were independent factors associated with severity, whereas old pulmonary tuberculosis, poor performance status, pneumococcal bacteremia, and severe pneumonia were independent factors that were associated with non-survival. Poor performance status was associated with the severity and mortality of pneumococcal pneumonia.
The Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Saitama, Japan. Electronic address: ishiguro.takashi@pref.saitama.lg.jp.
Takashi
T
Ishiguro
The Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Saitama, Japan.
Naho
N
Kagiyama
Department of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Ryuji
R
Uozumi
The Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Saitama, Japan.
Kyuto
K
Odashima
The Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Saitama, Japan.
Kazuyoshi
K
Kurashima
Department of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Satoshi
S
Morita
The Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Saitama, Japan.
Noboru
N
Takayanagi
D000203:Activities of Daily Living; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000453:epidemiology; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011018:Pneumonia, Pneumococcal / Q000382:microbiology / Q000401:mortality*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D013296:Streptococcus pneumoniae / Q000302:isolation & purification; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology
Mortality; Performance status; Pneumococcal pneumonia; Prognostic factor; Severe; Streptococcus pneumoniae