Gating Immunity and Death at the Nuclear Pore Complex.
The nuclear pore complex is the primary conduit for nuclear import and export of molecules. In this issue, Gu et al. uncover a novel mechanism in which immune signaling and programmed cell death require nuclear pore rearrangement and release of sequestered cyclin-dependent kinase inhibitors to elicit immunity and death.
Division of Molecular and Cellular Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: dassom@mail.nih.gov.
Mary
M
Dasso
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: beatriz.fontoura@utsouthwestern.edu.
Beatriz M A
BMA
Fontoura
D021581:Active Transport, Cell Nucleus; D002467:Cell Nucleus / Q000378:metabolism; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D006801:Humans; D022022:Nuclear Pore / Q000378:metabolism*; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism; D015398:Signal Transduction
D028861:Nuclear Pore Complex Proteins; D018844:Cyclin-Dependent Kinases