Towards a Better Treatment Option for Parkinson's Disease: A Review of Adult Neurogenesis.
The motor symptoms of Parkinson's disease (PD) are caused by degeneration of dopamine (DA) neurons in the substantia nigra pars compacta (SNc) of midbrain. Given the fact that current treatment options are mostly symptomatic and based on increasing DA level in the nigrostriatal system, it is generally believed the most effective and long-lasting treatment for PD motor symptoms will be replacing SNc DA cells, either by endogenous repair (i.e. neurogenesis) or cell transplantation. While cell transplantation is hindered by failure of acquisition and maintenance of the DA phenotype by transplanted cells, hope rests upon non-invasive cell replacement therapy (CRT) with endogenous neural stem cells, which have the potential to give rise to new neurons including DA neurons. Understanding underlying mechanisms and signalling pathways of neurogenesis in the adult brain could shed light on obstacles to achieve effective CRTs and better treatments for PD. This paper first reviews different therapeutic strategies in context of PD along with their advantages and disadvantages followed by an extensive review of adult neurogenesis.
Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, 3010, Australia. parisa.farzanehfar@florey.edu.au.|St Vincent's Hospital, Fitzroy, Victoria, 3065, Australia. parisa.farzanehfar@florey.edu.au.
Parisa
http://orcid.org/0000-0002-6221-4077
P
Farzanehfar
D000818:Animals; D000978:Antiparkinson Agents / Q000627:therapeutic use; D001921:Brain / Q000473:pathology; D046690:Deep Brain Stimulation; D059290:Dopaminergic Neurons / Q000473:pathology; D015316:Genetic Therapy; D006801:Humans; D058953:Neural Stem Cells / Q000637:transplantation; D055495:Neurogenesis; D009474:Neurons / Q000473:pathology*; D010300:Parkinson Disease / Q000473:pathology / Q000628:therapy*
D000978:Antiparkinson Agents
Adult neurogenesis; BrdU+ cells; Midbrain; Parkinson’s disease; Stem cells; Striatum; Substantia Nigra (SN)