[Expression and significance of discoidin domain receptor 1 in salivary gland mucoepidermoid carcinoma].
OBJECTIVE
To investigate the expression and significance of discoidin domain receptor 1 (DDR1) in salivary gland mucoepidermoid carcinoma (MEC).


METHODS
Immunohistochemical and Western blot method were used to detect the expression of DDR1 in MEC M3SP2 and MC3 cell lines. Immunohistochemical method was used to detect the expression of DDR1 in 58 MEC and 20 normal salivary gland tissues. SPSS 13.0 software package was used for statistical analysis.


RESULTS
The positive expression rate of DDR1 in salivary gland MEC tissues was 79.3%, significantly higher than 10.0% in normal salivary gland tissues (P<0.01). High expression of DDR1 was not related to clinicopathological parameters of MEC(P>0.05). The expression of DDR1 was positive in MEC M3SP2 and MC3 cell lines.


CONCLUSIONS
DDR1 may play an important role in carcinogenesis and progress of salivary gland MEC.
Shengjing Hospital of China Medical University. Shenyang 110004, Liaoning Province, China. E-mail:wangzm@sj-hospital.org.
Zhi-Ming
ZM
Wang
Hui-Yuan
HY
Wen
Dong-Sheng
DS
Yang
Ming
M
Ye
Ying
Y
Ma
Li-Ping
LP
Zhang
D018277:Carcinoma, Mucoepidermoid / Q000175:diagnosis / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell; D000070822:Discoidin Domain; D000070819:Discoidin Domain Receptor 1 / Q000378:metabolism*; D006258:Head and Neck Neoplasms; D006801:Humans; D012468:Salivary Gland Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D012469:Salivary Glands; D000077195:Squamous Cell Carcinoma of Head and Neck
D000070819:Discoidin Domain Receptor 1