Statins in Asthma: A Closer Look into the Pharmacological Mechanism of Action.
The effect of stains in asthma is mediated through targeting several signaling molecules that are involved in the development of asthma phenotype. In vitro and in vivo studies revealed that statins reduce airway smooth muscle cells proliferation and inflammatory mediators' release. Statins reduce chemokine release and mucus production from airway epithelial cells besides attenuating subepithelial fibrosis and eosinophils recruitment. In acute and chronic allergen driven animal models of asthma, statins reduce airway hyper-responsiveness, inflammation and remodeling. However, the effectiveness of statins in clinical trials results in contradictory conclusions based on study design and treatment protocol. Therefore, more clinical trials are needed to evaluate their role in asthma patients.
College of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
Nour A
NA
Al-Sawalha
Brian J
BJ
Knoll
D056151:Airway Remodeling / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001249:Asthma / Q000188:drug therapy* / Q000378:metabolism*; D016535:Bronchial Hyperreactivity / Q000188:drug therapy / Q000378:metabolism; D002986:Clinical Trials as Topic / Q000379:methods; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use*; D032389:Myocytes, Smooth Muscle / Q000187:drug effects / Q000378:metabolism
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors