Role of NADPH Oxidase in Metabolic Disease-Related Renal Injury: An Update.
Metabolic syndrome has been linked to an increased risk of chronic kidney disease. The underlying pathogenesis of metabolic disease-related renal injury remains obscure. Accumulating evidence has shown that NADPH oxidase is a major source of intrarenal oxidative stress and is upregulated by metabolic factors leading to overproduction of ROS in podocytes, endothelial cells, and mesangial cells in glomeruli, which is closely associated with the initiation and progression of glomerular diseases. This review focuses on the role of NADPH oxidase-induced oxidative stress in the pathogenesis of metabolic disease-related renal injury. Understanding of the mechanism may help find potential therapeutic strategies.
Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.
Cheng
0000-0002-4129-6413
C
Wan
Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.
Hua
H
Su
Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.
Chun
0000-0003-3565-8024
C
Zhang
D000818:Animals; D003928:Diabetic Nephropathies / Q000201:enzymology / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000201:enzymology* / Q000473:pathology*; D008659:Metabolic Diseases / Q000201:enzymology* / Q000473:pathology*; D008954:Models, Biological; D019255:NADPH Oxidases / Q000378:metabolism
D019255:NADPH Oxidases