Epigenetic Mechanisms in Psychiatric Diseases and Epigenetic Therapy.
Preclinical Research Epigenetic mechanisms refer covalent modification of DNA and histone proteins that control transcriptional regulation of gene expression. Epigenetic regulation is involved in the development of the nervous system and plays an important role in the pathophysiology of psychiatric disorders, including depression, bipolar disorder, and schizophrenia. Epigenetic drugs, including histone deacetylation and DNA methylation inhibitors have received increased attention for the management of psychiatric diseases. The purpose of this review is to discuss the potential of epigenetic drugs to treat these disorders and to clarify the mechanisms by which they regulate the dysfunctional genes in the brain. Drug Dev Res 77 : 407-413, 2016. © 2016 Wiley Periodicals, Inc.
Faculty of Pharmacy, Department of Toxicology, Marmara University, Istanbul, Turkey.
Seher
S
Karsli-Ceppioglu
D000818:Animals; D019175:DNA Methylation / Q000187:drug effects; D015195:Drug Design; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology
D056572:Histone Deacetylase Inhibitors
DNMT inhibitors; HDAC inhibitors; epigenetics; psychiatric diseases