UVR protection influences fructosamine level after sun exposure of healthy adults.
BACKGROUND
Seasonal variation in glycated hemoglobin levels has been observed, and sun exposure has been considered as one of the factors associated with this relationship. Fructosamine is a short-time marker of blood protein glycation.


OBJECTIVE
We investigated the effect of seven days of sunbathing on blood fructosamine concentration in healthy volunteers using different ultraviolet radiation (UVR) protections.


METHODS
Participants were assigned to one of three groups: group A - used a UVA and UVB absorbing sunscreen (N = 15), group B - used a UVB absorbing sunscreen (N = 18), and group C - followed uncontrolled sun protection habits (N = 22).


RESULTS
Overall, the fructosamine concentration did not change after sun exposure (baseline 248.8 μmol/l, 25-75%: 238.5 to 258.8 μmol/l vs. after 247.3 μmol/l, 25-75%: 234.9 to 261.8 μmol/l, P = 0.6637). Median change of fructosamine differed significantly between groups (A: -1.90 μmol/l, 25-75%: -17.10 to 1.80 μmol/l vs. B: -3.80 μmol/l, 25-75%: -18.50 to 2.40 μmol/l vs. C: +4.05 μmol/l, 25-75%: -3.20 to 22.0 μmol/l; one-way ANOVAP = 0.0277). After age adjustment and combining groups A and B, the difference in change of fructosamine concentration was statistically significant between groups A + B (decrease) vs. group C (increase, P = 0.0193).


CONCLUSIONS
Appropriate sunscreen use during sunbathing resulted in decreased fructosamine concentrations, while inadequate UVR protection resulted in its increase.
Department of Paediatrics, Oncology, Haematology and Diabetology, Medical University of Lodz, Lodz, Poland.
Beata
B
Mianowska
Department of Dermatology, Medical University of Lodz, Lodz, Poland.
Joanna
J
Narbutt
St John's Institute of Dermatology, King's College London, London, UK.
Antony Richard
AR
Young
Department of Paediatrics, Oncology, Haematology and Diabetology, Medical University of Lodz, Lodz, Poland.
Wojciech
W
Fendler
Department of Paediatrics, Oncology, Haematology and Diabetology, Medical University of Lodz, Lodz, Poland.
Beata
B
Małachowska
Department of Paediatrics, Oncology, Haematology and Diabetology, Medical University of Lodz, Lodz, Poland.
Wojciech
W
Młynarski
Department of Dermatology, Medical University of Lodz, Lodz, Poland.
Aleksandra
A
Lesiak
D000328:Adult; D005260:Female; D019270:Fructosamine / Q000097:blood*; D006801:Humans; D008297:Male; D013030:Spain; D013472:Sunlight; D013473:Sunscreening Agents / Q000008:administration & dosage*
D013473:Sunscreening Agents; D019270:Fructosamine
fructosamine; glucose; sun exposure; sunscreen; ultraviolet radiation