The Role of New Oral Anticoagulants (NOACs) in Cancer Patients.
New oral anticoagulants (NOACs) are likely to have a major impact in the next few years, changing clinical practice of anticoagulation therapy. Evidence on its efficacy and superiority to vitamin K antagonists (VKAs) in treating non-cancer patients have been reported in a few clinical trials. However, patients with cancer are complicated by the prothrombotic nature of the disease, need for potentially invasive surgery and interventions, and altered drug handling. This chapter examines the available evidence and guidelines on the use of NOAC in patients with cancer.
Academic Section of Vascular Surgery, Department of Surgery and Cancer, Imperial College London, Room 4N13C, Charing Cross Hospital, Fulham Palace Road, London, W6 8RF, UK. r.ravikumar@imperial.ac.uk.
Raveena
R
Ravikumar
Academic Section of Vascular Surgery, Department of Surgery and Cancer, Imperial College London, London, UK.
Chung Sim
CS
Lim
Academic Section of Vascular Surgery, Department of Surgery and Cancer, Imperial College London, London, UK.
Alun Huw
AH
Davies
D000284:Administration, Oral; D000925:Anticoagulants / Q000627:therapeutic use*; D000991:Antithrombins / Q000627:therapeutic use; D002408:Catheters, Indwelling; D000069604:Dabigatran / Q000627:therapeutic use; D004334:Drug Administration Schedule; D054796:Drug Dosage Calculations; D006801:Humans; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D011720:Pyrazoles / Q000627:therapeutic use; D011725:Pyridines / Q000627:therapeutic use; D011728:Pyridones / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D000069552:Rivaroxaban / Q000627:therapeutic use; D013844:Thiazoles / Q000627:therapeutic use; D054556:Venous Thromboembolism / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D020246:Venous Thrombosis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology
D000925:Anticoagulants; D000991:Antithrombins; D011720:Pyrazoles; D011725:Pyridines; D011728:Pyridones; D013844:Thiazoles; C522181:apixaban; D000069552:Rivaroxaban; D000069604:Dabigatran; C552171:edoxaban
Cancer; Deep venous thrombosis; Direct oral anticoagulants; New oral anticoagulants; Pulmonary embolism; Venous thromboembolism