Production of Pure Aqueous13C-Hyperpolarized Acetate by Heterogeneous Parahydrogen-Induced Polarization.
A supported metal catalyst was designed, characterized, and tested for aqueous phase heterogeneous hydrogenation of vinyl acetate with parahydrogen to produce13C-hyperpolarized ethyl acetate for potential biomedical applications. The Rh/TiO2catalyst with a metal loading of 23.2 wt % produced strongly hyperpolarized13C-enriched ethyl acetate-1-13C detected at 9.4 T. An approximately 14-fold13C signal enhancement was detected using circa 50 % parahydrogen gas without taking into account relaxation losses before and after polarization transfer by magnetic field cycling from nascent parahydrogen-derived protons to13C nuclei. This first observation of13C PHIP-hyperpolarized products over a supported metal catalyst in an aqueous medium opens up new possibilities for production of catalyst-free aqueous solutions of nontoxic hyperpolarized contrast agents for a wide range of biomolecules amenable to the parahydrogen induced polarization by side arm hydrogenation (PHIP-SAH) approach.
Laboratory of Magnetic Resonance Microimaging, International Tomography Center, SB RAS, 3A Institutskaya St., Novosibirsk, 630090, Russia. kovtunov@tomo.nsc.ru.|Novosibirsk State University, 2 Pirogova St., Novosibirsk, 630090, Russia. kovtunov@tomo.nsc.ru.
Kirill V
http://orcid.org/0000-0001-7577-9619
KV
Kovtunov
Department of Radiology, Department of Biomedical Engineering, Department of Physics and Astronomy, Vanderbilt University Institute of Imaging Science (VUIIS), Nashville, Tennessee, 37232-2310, USA.
Danila A
http://orcid.org/0000-0002-2819-7584
DA
Barskiy
Department of Radiology, Department of Biomedical Engineering, Department of Physics and Astronomy, Vanderbilt University Institute of Imaging Science (VUIIS), Nashville, Tennessee, 37232-2310, USA.
Roman V
RV
Shchepin
Laboratory of Magnetic Resonance Microimaging, International Tomography Center, SB RAS, 3A Institutskaya St., Novosibirsk, 630090, Russia.|Novosibirsk State University, 2 Pirogova St., Novosibirsk, 630090, Russia.
Oleg G
OG
Salnikov
Novosibirsk State University, 2 Pirogova St., Novosibirsk, 630090, Russia.|Boreskov Institute of Catalysis SB RAS, 5 Acad. Lavrentiev Pr., Novosibirsk, 630090, Russia.
Igor P
http://orcid.org/0000-0002-0351-5128
IP
Prosvirin
Novosibirsk State University, 2 Pirogova St., Novosibirsk, 630090, Russia.|Boreskov Institute of Catalysis SB RAS, 5 Acad. Lavrentiev Pr., Novosibirsk, 630090, Russia.
Andrey V
http://orcid.org/0000-0002-0199-8111
AV
Bukhtiyarov
Novosibirsk State University, 2 Pirogova St., Novosibirsk, 630090, Russia.|Boreskov Institute of Catalysis SB RAS, 5 Acad. Lavrentiev Pr., Novosibirsk, 630090, Russia.
Larisa M
LM
Kovtunova
Novosibirsk State University, 2 Pirogova St., Novosibirsk, 630090, Russia.|Boreskov Institute of Catalysis SB RAS, 5 Acad. Lavrentiev Pr., Novosibirsk, 630090, Russia.
Valerii I
http://orcid.org/0000-0003-4382-1207
VI
Bukhtiyarov
Laboratory of Magnetic Resonance Microimaging, International Tomography Center, SB RAS, 3A Institutskaya St., Novosibirsk, 630090, Russia. koptyug@tomo.nsc.ru.|Novosibirsk State University, 2 Pirogova St., Novosibirsk, 630090, Russia. koptyug@tomo.nsc.ru.
Igor V
http://orcid.org/0000-0003-3480-7649
IV
Koptyug
Department of Radiology, Department of Biomedical Engineering, Department of Physics and Astronomy, Vanderbilt University Institute of Imaging Science (VUIIS), Nashville, Tennessee, 37232-2310, USA. eduard.chekmenev@vanderbilt.edu.|Russian Academy of Sciences, Leninskiy Prospekt 14, 119991, Moscow, Russia. eduard.chekmenev@vanderbilt.edu.
Eduard Y
http://orcid.org/0000-0002-8745-8801
EY
Chekmenev
13C NMR; PHIP; hyperpolarization; parahydrogen; polarization transfer