Evaluation of Tp-e Interval, Tp-e/QT Ratio, and Tp-e/QTc Ratio in Patients with Asymptomatic Arrhythmogenic Right Ventricular Cardiomyopathy.
BACKGROUND
Arrhythmogenic right ventricular dysplasia (ARVD) is characterized by progressive replacement of ventricular myocytes with variable amounts of fibrous and adipose tissue. Several studies have suggested that the interval from the peak to the end of the electrocardiographic T wave (Tp-e) may correspond to the transmural dispersion of repolarization and that increased Tp-e interval and Tp-e/QT ratio are associated with malignant ventricular arrhythmias. The aim of this study was to evaluate repolarization dispersion measured from the 12-lead surface electrocardiogram (including Tp-e interval, Tp-e/QT, and Tp-e/QTc ratio) in asymptomatic ARVD patients METHODS: We selected 27 patients with asymptomatic ARVD and 27 age- and gender-match young, healthy volunteers.


RESULTS
Tp-e interval, Tp-e/QT and Tp-e/QTc ratio were also significantly higher in ARVD group compared to the control group (all P < 0.001). There were negative correlation between S global and Tp-e, Tp-e/QT, Tp-e/QTc ration (r = -0.57, P = 0.02; r = -0.85, P = 0.02; r = -0.63, P < 0.01; respectively). There were also negative correlation between Sm global and Tp-e, Tp-e/QT, Tp-e/QTc ration (r = -0.61, P < 0.01; r = -0.67, P < 0.01; r = -0.68, P < 0.01; respectively). Moreover, Em global were negative correlation between Tp-e, Tp-e/QT, and Tp-e/QTc (r = - 0.64, P < 0.001, r = - 0.75, P < 0.01; r = -0,69, P < 0.01; respectively) CONCLUSION: In conclusion, we have presented strong evidence suggesting that Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio were increased in asymptomatic ARVD patients.
Kartal Kosuyolu Heart Research and Training Hospital, Cardiology Department, Istanbul, Turkey.
Elnur
E
Alizade
Kartal Kosuyolu Heart Research and Training Hospital, Cardiology Department, Istanbul, Turkey.
Mahmut
M
Yesin
Kartal Kosuyolu Heart Research and Training Hospital, Cardiology Department, Istanbul, Turkey.
Mehmet Vefik
MV
Yazicioğlu
Bagcılar Research and Training Hospital, Cardiology Department, Istanbul, Turkey.
Ekrem Bilal
EB
Karaayvaz
Istanbul University Faculty of Medicine, Cardiology Department, Istanbul, Turkey.
Adem
A
Atici
Gaziosmanpaşa State Hospital, Cardiology Department, Istanbul, Turkey.
Şükrü
Ş
Arslan
Kartal Kosuyolu Heart Research and Training Hospital, Cardiology Department, Istanbul, Turkey.
Anıl
A
Avci
Kartal Kosuyolu Heart Research and Training Hospital, Cardiology Department, Istanbul, Turkey.
Göksel
G
Acar
Kartal Kosuyolu Heart Research and Training Hospital, Cardiology Department, Istanbul, Turkey.
Mustafa
M
Tabakci
Kartal Kosuyolu Heart Research and Training Hospital, Cardiology Department, Istanbul, Turkey.
Servet
S
Izci
Kartal Kosuyolu Heart Research and Training Hospital, Cardiology Department, Istanbul, Turkey.
Selçuk
S
Pala
D000328:Adult; D019571:Arrhythmogenic Right Ventricular Dysplasia / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D004452:Echocardiography; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D015203:Reproducibility of Results
Tp-e interval; arrhythmogenic right ventricular dysplasia; electrocardiography; ventricular arrhythmias