Effect of molecular weight of hyaluronic acid (HA) on viscoelasticity and particle texturing feel of HA dermal biphasic fillers.
BACKGROUND
Hyaluronic acid (HA) dermal biphasic fillers are synthesized for their efficacy in correcting aesthetic defects such as wrinkles, scars and facial contouring defects. The fillers consist of crosslinked HA microspheres suspended in a noncrosslinked HA. To extend the duration of HAs within the dermis and obtain the particle texturing feel, HAs are crosslinked to obtain the suitable mechanical properties.


RESULTS
Hyaluronic acid (HA) dermal biphasic fillers are prepared by mixing the crosslinked HA microspheres and the noncrosslinked HAs. The elastic modulus of the fillers increased with raising the volume fraction of the microspheres. The mechanical properties and the particle texturing feel of the fillers made from crosslinked HA (1058 kDa) microspheres suspended in noncrosslinked HA (1368 kDa) are successfully achieved, which are adequate for the fillers.


CONCLUSIONS
Dermal biphasic HA fillers made from 1058 kDa exhibit suitable elastic moduli (211 to 420 Pa) and particle texturing feel (scale 7 ~ 9).
Department of Biomedical Engineering, Daelim University, Anyang, 13916 Republic of Korea.
Cheolbyong
C
Chun
Department of Biomedical Engineering, Daelim University, Anyang, 13916 Republic of Korea.
Deuk Yong
0000-0003-1674-412X
DY
Lee
Department of Biomedical Engineering, Daelim University, Anyang, 13916 Republic of Korea.
Jin-Tae
JT
Kim
R&D Center, Neobiotech Co., Ltd, Seoul, 152-789 Republic of Korea.
Mi-Kyung
MK
Kwon
Vericom Co., Ltd, Anyang, 606-72 Republic of Korea.
Young-Zu
YZ
Kim
Beautiful Revolution Co., Ltd., Seoul, 135-513 Republic of Korea.
Seok-Soon
SS
Kim
Dermal biphasic filler; Elastic modulus; Hyaluronic acid; Microsphere; Particle texturing feel