Reduction of postoperative adhesion development.
Despite use of meticulous surgical techniques, and regardless of surgical access via laparotomy or laparoscopy, postoperative adhesions develop in the vast majority of women undergoing abdominopelvic surgery. Such adhesions represent not only adhesion reformation at sites of adhesiolysis, but also de novo adhesion formation at sites of surgical procedures. Application of antiadhesion adjuvants compliment the benefits of meticulous surgical techniques, providing an opportunity to further reduce postoperative adhesion development. Improved understanding of the pathophysiology of adhesion development and distinguishing variations in the molecular biologic mechanisms from adhesion-free peritoneal repair represent future opportunities to improve the reduction of postoperative adhesions. Optimization of the reduction of postoperative adhesions will likely require identification of unique, personalized approaches in each individual, representing interindividual variation in peritoneal repair processes.
Department of Obstetrics and Gynecology, Medical College of Georgia, Augusta University, Augusta, Georgia. Electronic address: Michael.diamond@augusta.edu.
Michael P
MP
Diamond
D002483:Cellulose, Oxidized / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005936:Glucans / Q000009:adverse effects / Q000627:therapeutic use*; D005947:Glucose / Q000009:adverse effects / Q000627:therapeutic use*; D013509:Gynecologic Surgical Procedures / Q000009:adverse effects*; D006801:Humans; D006820:Hyaluronic Acid / Q000009:adverse effects / Q000627:therapeutic use*; D000077607:Icodextrin; D018384:Oxidative Stress; D011183:Postoperative Complications / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D018570:Risk Assessment; D012307:Risk Factors; D000267:Tissue Adhesions; D016896:Treatment Outcome; D014945:Wound Healing
D002483:Cellulose, Oxidized; D005936:Glucans; C060002:INTERCEED; C118198:Seprafilm; D000077607:Icodextrin; D006820:Hyaluronic Acid; D005947:Glucose
Adhesion development; adhesion reformation; antiadhesion adjuvants; de novo adhesion formation; postoperative adhesions