Patient-specific CFD simulation of intraventricular haemodynamics based on 3D ultrasound imaging.
BACKGROUND
The goal of this paper is to present a computational fluid dynamic (CFD) model with moving boundaries to study the intraventricular flows in a patient-specific framework. Starting from the segmentation of real-time transesophageal echocardiographic images, a CFD model including the complete left ventricle and the moving 3D mitral valve was realized. Their motion, known as a function of time from the segmented ultrasound images, was imposed as a boundary condition in an Arbitrary Lagrangian-Eulerian framework.


RESULTS
The model allowed for a realistic description of the displacement of the structures of interest and for an effective analysis of the intraventricular flows throughout the cardiac cycle. The model provides detailed intraventricular flow features, and highlights the importance of the 3D valve apparatus for the vortex dynamics and apical flow.


CONCLUSIONS
The proposed method could describe the haemodynamics of the left ventricle during the cardiac cycle. The methodology might therefore be of particular importance in patient treatment planning to assess the impact of mitral valve treatment on intraventricular flow dynamics.
ELIS Department, IBiTech-bioMMeda, Ghent University, Ghent, Belgium. Alessandra.Bavo@ugent.be.
A M
http://orcid.org/0000-0002-1085-5008
AM
Bavo
Gorman Cardiovascular Research Group, University of Pennsylvania, Philadelphia, PA, USA.
A M
AM
Pouch
Department of Flow, Heat and Combustion Mechanics, Ghent University, Ghent, Belgium.
J
J
Degroote
Department of Flow, Heat and Combustion Mechanics, Ghent University, Ghent, Belgium.
J
J
Vierendeels
Gorman Cardiovascular Research Group, University of Pennsylvania, Philadelphia, PA, USA.
J H
JH
Gorman
Gorman Cardiovascular Research Group, University of Pennsylvania, Philadelphia, PA, USA.
R C
RC
Gorman
ELIS Department, IBiTech-bioMMeda, Ghent University, Ghent, Belgium.
P
P
Segers
D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006439:Hemodynamics; D006801:Humans; D057446:Hydrodynamics; D021621:Imaging, Three-Dimensional; D008955:Models, Cardiovascular; D066230:Patient-Specific Modeling; D014463:Ultrasonography; D016276:Ventricular Function
CFD model with prescribed moving boundaries; Intraventricular flow; Patient-specific modeling; Real-time transesophageal ultrasound images