Prekallikrein deficiency in a 15-year-old boy with Ménière's disease: a case report.
Congenital prekallikrein deficiency is a rare disorder in which there is an in vitro clotting defect despite absence of bleeding or thrombotic tendency. In this report, a 15-year-old boy with an unexpected markedly prolonged activated partial thrombin time, a normal prothrombin time, and without personal nor familial history of bleeding or thrombosis is presented. Laboratory investigation revealed a severe prekallikrein deficiency. This case highlights the importance of following a diagnostic algorithm to establish the correct diagnosis. Moreover, by selecting appropriate laboratory tests, unnecessary and repeatedly testing can be avoided.
a Department of Laboratory Hematology , GZA Sint-Augustinus , Antwerp , Belgium.
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M
Criel
b Department of Otorhinolaryngology , GZA Hospitals , Antwerp , Belgium.
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F
Declau
c Department of Hematology , GZA Hospitals , Antwerp , Belgium.
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Schuermans
a Department of Laboratory Hematology , GZA Sint-Augustinus , Antwerp , Belgium.
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http://orcid.org/0000-0001-6636-1771
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Ver Elst
a Department of Laboratory Hematology , GZA Sint-Augustinus , Antwerp , Belgium.
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S
Vermeiren
a Department of Laboratory Hematology , GZA Sint-Augustinus , Antwerp , Belgium.
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S
Weekx
c Department of Hematology , GZA Hospitals , Antwerp , Belgium.
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http://orcid.org/0000-0001-6069-8891
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Lemmens
D000293:Adolescent; D001778:Blood Coagulation Disorders / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000150:complications* / Q000175:diagnosis*; D011288:Prekallikrein / Q000172:deficiency*
D011288:Prekallikrein
Prekallikrein deficiency; Prolonged aPTT