Application of Systems Biology to Neuroproteomics: The Path to Enhanced Theranostics in Traumatic Brain Injury.
The application of systems biology tools in analyzing heterogeneous data from multiple sources has become a necessity, especially in biomarker discovery. Such tools were developed with several approaches to address different types of research questions and hypotheses. In the field of neurotrauma and traumatic brain injury (TBI), three distinct approaches have been used so far as systems biology tools, namely functional group categorization, pathway analysis, and protein-protein interaction (PPI) networks. The databases allow for query of the system to identify candidate targets which can be further studied to elucidate potential downstream biomarkers indicative of disease progression, severity, and improvement. The various systems biology tools, databases, and strategies that can be implemented on available TBI data in neuroproteomic studies are discussed in this chapter.
Department of Biochemistry, Graduate School and University Center of CUNY, 365 Fifth Avenue, New York, NY, 10016, USA. zjaber@gradcenter.cuny.edu.|Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon. zjaber@gradcenter.cuny.edu.
Zaynab
Z
Jaber
Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon.
Patrick
P
Aouad
Division of Vascular Endothelium and Microcirculation, Department of Medicine III, University Hospital Carl Gustav Carus, TU Dresden, Fetscherstr. 74, 01307, Dresden, Germany.
Mohamad
M
Al Medawar
Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.|Faculty of Medicine, Beirut Arab University, Beirut, Lebanon.
Hisham
H
Bahmad
Faculty of Medicine, Beirut Arab University, Beirut, Lebanon.|Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Hussein
H
Abou-Abbass
Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon. firasko@gmail.com.|Department of Psychiatry, Center for Neuroproteomics and Biomarkers Research, University of Florida, 4000 SW 23rd St., Apt. 5-204, Gainesville, FL, 32608, USA. firasko@gmail.com.|Banyan Biomarkers, Inc, Alachua, FL, USA. firasko@gmail.com.
Firas
F
Kobeissy
D015415:Biomarkers; D000070642:Brain Injuries, Traumatic / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D006801:Humans; D025941:Protein Interaction Mapping; D060066:Protein Interaction Maps; D020543:Proteome; D040901:Proteomics / Q000379:methods; D015398:Signal Transduction; D049490:Systems Biology / Q000379:methods; D000068936:Theranostic Nanomedicine
D015415:Biomarkers; D020543:Proteome
Functional group categorization; Neurotrauma; Pathway analysis; Protein-protein interaction network; Systems biology; TBI