The Difference of Chemical Components and Biological Activities of the Crude Products and the Salt-Processed Product from Semen Cuscutae.
Semen Cuscutae is a well-known Chinese medicine which has been used to nourish kidney in China for thousands of years. The crude product of semen Cuscutae (CP) and its salt-processed product (SPP) are separately used in clinic for their different effects. The study was designed to investigate the influence of processing from semen Cuscutae on chemical components and biological effects. The principal component analysis and quantitative analysis were used to study the differences of the chemical components. The effects of nourishing kidney were detected to compare the differences between the CP and SPP. The PCA results showed that the obvious separation was achieved in the CP and SPP samples. The results of quantitative analysis showed that quercetin and total flavonoids had significantly increased after salt processing while hyperoside had decreased. The comparison of CP and SPP on biological activities showed that both of them could ameliorate the kidney-yang deficiency syndrome by restoring the level of sex hormone, improving the immune function and antioxidant effect. However, SPP was better in increasing the level of T and the viscera weight of testicle and epididymis, improving the antioxidant effect. The results suggested that salt processing changed its chemical profile, which in turn enhanced its biological activities.
School of Chinese Materia Medica, Beijing University of Chinese Medicine, No. 6 Wangjing Zhonghuan Nan Road, Beijing 100102, China.
Song
S
Yang
School of Chinese Materia Medica, Beijing University of Chinese Medicine, No. 6 Wangjing Zhonghuan Nan Road, Beijing 100102, China.
Hefang
H
Xu
School of Basic Medical Sciences, Beijing University of Chinese Medicine, No. 11 North Third Ring Road, Beijing 100029, China.
Baosheng
B
Zhao
School of Chinese Materia Medica, Beijing University of Chinese Medicine, No. 6 Wangjing Zhonghuan Nan Road, Beijing 100102, China.
Shasha
S
Li
School of Chinese Materia Medica, Beijing University of Chinese Medicine, No. 6 Wangjing Zhonghuan Nan Road, Beijing 100102, China.
Tingting
T
Li
School of Chinese Materia Medica, Beijing University of Chinese Medicine, No. 6 Wangjing Zhonghuan Nan Road, Beijing 100102, China.
Xinfang
X
Xu
School of Basic Medical Sciences, Beijing University of Chinese Medicine, No. 11 North Third Ring Road, Beijing 100029, China.
Tianjiao
T
Zhang
School of Chinese Materia Medica, Beijing University of Chinese Medicine, No. 6 Wangjing Zhonghuan Nan Road, Beijing 100102, China; Beijing Key Laboratory of Chinese Materia Medica Quality Evaluation, Beijing University of Chinese Medicine, No. 11 North Third Ring Road, Beijing 100029, China.
Ruichao
R
Lin
School of Basic Medical Sciences, Beijing University of Chinese Medicine, No. 11 North Third Ring Road, Beijing 100029, China.
Jian
0000-0002-8864-0621
J
Li
School of Chinese Materia Medica, Beijing University of Chinese Medicine, No. 6 Wangjing Zhonghuan Nan Road, Beijing 100102, China; Beijing Key Laboratory of Chinese Materia Medica Quality Evaluation, Beijing University of Chinese Medicine, No. 11 North Third Ring Road, Beijing 100029, China.
Xiangri
0000-0002-1730-5455
X
Li