Sacral neuromodulation for refractory overactive bladder after prior intravesical onabotulinumtoxinA treatment.
OBJECTIVE
Sacral neuromodulation (SNM) is a well-established treatment modality for refractory overactive bladder (OAB). There is a paucity of evidence examining the use of SNM in patients who have received prior intravesical onabotulinumtoxinA (BTXA) treatment. We aim to review those patients who underwent SNM for refractory OAB following treatment with BTXA.


METHODS
A retrospective review was conducted to identify patients who had undergone prior intradetrusor BTXA for refractory OAB, then subsequent first-stage SNM. Patient demographics, number/dosage of BTXA, voiding diaries, and patient global impression of improvement (PGI-I) scores were recorded. Successful first-stage SNM was defined as subjective patient improvement of greater than 50%. Patient satisfaction and device use at last follow-up was noted.


RESULTS
Eighty-three patients were identified having undergone SNM for OAB, of which 36 had prior BTXA treatment and were included in the series. 23/36 (63.9%) of patients had successful first-stage SNM, and underwent insertion of implantable pulse generator, compared to 33/47 (70.2%) in those who had never been treated with BTXA (P = 0.5). Mean PGI-I score was 2.6 (range 1-4). With a mean follow up of 29.1 months (range 12-53), 17/23 (73.9%) were satisfied, and using the device at last follow-up.


CONCLUSIONS
SNM is a suitable treatment option in those patients who have had prior BTXA treatment for refractory OAB, even in those for whom BTXA proved ineffective. Success rates were within the published range, and comparable to our own results, for SNM in OAB patients without prior BTXA treatment.
Austin Hospital, Melbourne, Australia.
Nathan
N
Hoag
Repatriation General Hospital, Adelaide, Australia.
Sophie
S
Plagakis
Continence Matters, Adelaide, Australia.
Samantha
S
Pillay
Continence Matters, Adelaide, Australia.
Ailsa Wilson
AW
Edwards
Austin Hospital, Melbourne, Australia.
Johan
J
Gani
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D004599:Electric Stimulation Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019233:Retreatment; D012189:Retrospective Studies; D012447:Sacrum; D016896:Treatment Outcome; D053201:Urinary Bladder, Overactive / Q000188:drug therapy / Q000628:therapy*; D055815:Young Adult
D019274:Botulinum Toxins, Type A
botulinum toxin A; overactive bladder; sacral neuromodulation; urgency urinary incontinence