Low glycemic index diet reduces body fat and attenuates inflammatory and metabolic responses in patients with type 2 diabetes.
OBJECTIVE
The aim of this study was to verify the effects of glycemic index (GI) on body composition, and on inflammatory and metabolic markers concentrations in patients with type 2 diabetes.


METHODS
In this randomized controlled parallel trial, twenty subjects (aged 42.4 ± 5.1 years, BMI 29.2 ± 4.8 kg.m-2) were allocated to low GI (LGI) (n = 10) or high GI (HGI) (n = 10) groups. Body composition, inflammatory and metabolic markers were assessed at baseline and after 30 days of intervention. Food intake was monitored during the study using three-day food records completed on two non-consecutive weekdays and on a weekend day.


RESULTS
Body fat reduced after the LGI intervention compared with baseline (P = 0.043) and with the HGI group (P = 0.036). Serum fructosamine concentration (P = 0.031) and TNF-α mRNA expression (P = 0.05) increased in the HGI group. Serum non-esterified fatty acids were greater in the HGI than in the LGI group (P = 0.032). IL-6 mRNA expression tended to decrease after the consumption of the LGI diet compared to baseline (P = 0.06).


CONCLUSIONS
The LGI diet reduced body fat and prevented the negative metabolic and inflammatory responses induced by the HGI diet.
Instituto Federal de Educação, Ciência e Tecnologia do Sudeste de Minas Gerais, Campus Barbacena, Barbacena, MG, Brasil.
Júnia Maria Geraldo
JMG
Gomes
Centro Universitário de Belo Horizonte, Campus Estoril, Belo Horizonte, MG, Brasil.
Sabrina Pinheiro
SP
Fabrini
Departamento de Nutrição e Saúde, Universidade Federal de Viçosa, Viçosa, MG, Brasil.
Rita de Cássia Gonçalves
RCG
Alfenas
D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D000886:Anthropometry; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy* / Q000378:metabolism*; D004043:Dietary Fiber / Q000032:analysis; D004435:Eating / Q000502:physiology; D005260:Female; D019270:Fructosamine / Q000097:blood; D038321:Glycemic Index / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D060888:Real-Time Polymerase Chain Reaction; D012016:Reference Values; D015203:Reproducibility of Results; D018709:Statistics, Nonparametric; D013997:Time Factors; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D001786:Blood Glucose; D004043:Dietary Fiber; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D019270:Fructosamine