Primary Adenocarcinoma of an Ileostomy in Crohn's Disease.
Although Crohn's disease has been associated with an increased risk of small bowel adenocarcinoma, primary adenocarcinoma arising from an ileostomy is a complication that has been rarely documented in Crohn's disease. Chronic small bowel inflammation may lead to development of malignancy through the dysplasia-carcinoma sequence. We report a case of a 61-year-old woman with Crohn's ileocolitis diagnosed with a primary adenocarcinoma at the ileostomy with metastases to the liver 47 years after proctocolectomy, and review the literature.
Division of Gastroenterology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Kevin
K
Liu
Atlanta VA Medical Center, Department of Digestive Diseases, Emory University School of Medicine, Atlanta, GA.
Meena A
MA
Prasad
Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, CA.
Amy
A
Lo
Division of Gastroenterology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Emanuelle
E
Bellaguarda
Division of Surgical Oncology, Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Scott
S
Strong
Division of Gastroenterology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Stephen B
SB
Hanauer