Potentiometric sensor fabrication having 2D sarcosine memories and analytical features.
In this study, a simple, rapid and sensitive method based on novel molecular imprinted polymeric sensor has been developed and validated for the determination of prostate cancer metabolite biomarker. The molecularly imprinted polymer (MIP) has been synthesized by emulsion polymerization, using sarcosine as template molecule, methacryloylamido histidine (MAH) as functional monomer and ethylene glycol dimethacrylate (EDMA) as cross-linking agent. The performance of the developed sarcosine sensor has been evaluated, and the results have indicated that a sensitive potentiometric sensor has been fabricated. The sarcosine sensor has showed high-selectivity, shorter response time (<2min), wider linear range (10(-2)-10(-6)mM), lower detection limit (1.35×10(-7)mM), and satisfactory long-term stability (>5.5months).
Department of Chemistry, Eskişehir Osmangazi University, Eskişehir, Turkey. Electronic address: ebirlik@ogu.edu.tr.
Ebru Birlik
EB
Özkütük
Department of Chemistry, Anadolu University, Eskişehir, Turkey.
Sibel Emir
SE
Diltemiz
Department of Chemistry, Eskişehir Osmangazi University, Eskişehir, Turkey.
Şeyma
Ş
Avcı
Department of Chemistry, Eskişehir Osmangazi University, Eskişehir, Turkey.
Deniz
D
Uğurağ
Department of Chemistry, Anadolu University, Eskişehir, Turkey.
Rabia Berna
RB
Aykanat
Department of Chemistry, Anadolu University, Eskişehir, Turkey.
Arzu
A
Ersöz
Department of Chemistry, Anadolu University, Eskişehir, Turkey.
Rıdvan
R
Say
D014408:Biomarkers, Tumor / Q000032:analysis; D006639:Histidine / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D054802:Molecular Imprinting; D011108:Polymers / Q000737:chemistry*; D011199:Potentiometry; D015203:Reproducibility of Results; D012521:Sarcosine / Q000032:analysis* / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared
D014408:Biomarkers, Tumor; D011108:Polymers; D006639:Histidine; D012521:Sarcosine
MIP; Potentiometric sensor; Prostate cancer; Sarcosine