An overview of the oxytocin-oxytocin receptor signaling network.
Oxytocin, a nine amino acid long neuropeptide hormone, is synthesized in the hypothalamus and stored and released from the neural lobe of the pituitary gland. Although commonly known for its central role in the regulation of parturition and lactation, oxytocin signaling also plays a key role in modulating social behavior, evoking contentment, initiating maternal behavior, inducing trust, generosity and bonding in humans and animals. Oxytocin signaling can prove to be of great importance in therapeutics and drug targeting because of its diverse range of actions. However, a well annotated map of oxytocin signaling pathway is currently lacking in the publicly available pathway resources. Therefore, we systematically curated the available signaling information of oxytocin from published literature and collated the data to develop a more complete map. We cataloged 66 molecules belonging to oxytocin signaling pathway, which included 9 protein-protein interactions, 39 post-translational modifications, 14 protein translocation events and 22 activation/inhibition events. Further, Oxytocin signaling network data is made freely available to academic fraternity by integrating this into NetPath ( http://www.netpath.org /), a freely available human signaling pathway resource developed previously by our group.
International Technology Park, Institute of Bioinformatics, Bangalore, 560066, India.
Oishi
O
Chatterjee
Molecular Endocrinology, National Institute for Research in Reproductive Health, Parel, Mumbai, 400012, India.
Krutika
K
Patil
International Technology Park, Institute of Bioinformatics, Bangalore, 560066, India.|Bioinformatics Centre, School of Life Sciences, Pondicherry University, Puducherry, 605014, India.
Apeksha
A
Sahu
International Technology Park, Institute of Bioinformatics, Bangalore, 560066, India.
Lathika
L
Gopalakrishnan
International Technology Park, Institute of Bioinformatics, Bangalore, 560066, India.
Praseeda
P
Mol
International Technology Park, Institute of Bioinformatics, Bangalore, 560066, India.|Manipal University, Madhav Nagar, Manipal, 576 104, India.
Jayshree
J
Advani
Molecular Endocrinology, National Institute for Research in Reproductive Health, Parel, Mumbai, 400012, India.
Srabani
S
Mukherjee
Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences, Bangalore, 560029, India.
Rita
R
Christopher
International Technology Park, Institute of Bioinformatics, Bangalore, 560066, India. keshav@ibioinformatics.org.|YU-IOB Center for Systems Biology and Molecular Medicine, Yenepoya University, Mangalore, 575018, India. keshav@ibioinformatics.org.|NIMHANS-IOB Proteomics and Bioinformatics Laboratory, National Institute of Mental Health and Neuro Sciences, Bangalore, 560029, India. keshav@ibioinformatics.org.
T S Keshava
TS
Prasad
G-protein coupled receptor; Gene expression; Herring bodies; Nociception; Osteoclastogenesis; Prostaglandins