Clinical study on the influence of phloroglucinol on plasma angiotensin II and D-Dimer index in patients with severe pregnancy-induced hypertension.
To observe the effect of phloroglucinol on plasma angiotensin II and D-dimer index when it was applied to patients with severe pregnancy-induced hypertension. 212 cases of severe pregnancy-induced hypertension patients diagnosed clinically were selected to be randomly divided into the research group and the control group. The research groups were given phloroglucinol, while the control groups were given magnesium sulfate. The plasma angiotensin II and D-dimer index in patients were detected before treatment and after 7 days respectively with statistical analysis of results. The diffidence after treatment was statistically significant (P<0.05). Compared within the same group, the difference of each index before and after treatment in the research group was statistically significant (P<0.05), while the control group was not statistically significant (P>0.05). It showed that the research group could reduce the plasma D-dimer and angiotensin II index in severe pregnancy-induced hypertension patients, and its effect was significantly better than the control group according to the plasma D-dimer and angiotensin II index changes in patients, it indicated that it was effective of phloroglucinol treatment for patients with pregnancy-induced hypertension disease and superior to the western medicine conventional treatment, worth clinical promotion.
Laboratory of Maternal and Child Health Care Hospital of Zhengzhou, Qinling Road and Ruhe Road, Zhengzhou, China.
Liang
L
Ai
Jilin Province, Han Nationality, Laboratorian-in-charge, Bachelor, Biochemistry, Longjing, China.
Xinzhi
X
Lan
Henan Province, Han Nationality, Deputy director of Laboratorian, Bachelor, Cells, Gongyi, China.
Limin
L
Wang
Henan Province, Han Nationality, Laboratorian, MM, Immunohematology, Qixian, China.
Yanjie
Y
Xu
Henan Province, Han Nationality, Laboratorian-in, Bachelor, Biochemistry, Dengzhou, China.
Bin
B
Zhang
D000328:Adult; D000804:Angiotensin II / Q000097:blood*; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood / Q000188:drug therapy*; D010696:Phloroglucinol / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D011247:Pregnancy
D000959:Antihypertensive Agents; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D000804:Angiotensin II; D010696:Phloroglucinol