Bursts of Chromosome Changes Drive TNBC.
A recent study suggests that complex genomic rearrangements in triple-negative breast cancer cells occur through a "Big Bang" model-early, short bursts of copy number aberrations, rather than progressive accumulation over time. Afterward, these aberrations are stably maintained in a handful of clones that expand to form the tumor mass.
D000782:Aneuploidy; D002467:Cell Nucleus / Q000235:genetics; D005260:Female; D018740:Genetic Heterogeneity; D006801:Humans; D008957:Models, Genetic; D017422:Sequence Analysis, DNA / Q000379:methods*; D059010:Single-Cell Analysis; D064726:Triple Negative Breast Neoplasms / Q000235:genetics*