Curcumin modulates oxidative stress and genotoxicity induced by a type II fluorinated pyrethroid, beta-cyfluthrin.
Present study examines the possibility of β-cyfluthrin (β-CYF) induced oxidative stress, genotoxicity, histopathological alterations and the role of curcumin (CUR) in alleviating its toxic effects. CUR is a naturally occurring phenolic compound of turmeric (Curcuma longa) and is used as a spice, food-coloring agent and in cosmetics and medicines. CUR provides vital protection against many pathological conditions due to its antioxidant and anti-inflammatory properties. Male Swiss albino mice were distributed into six groups, I: control, II: CUR (0.2%), III: β-CYF low dose (1/20 of LD50), IV: β-CYF high dose (1/10 of LD50), V: β-CYF low dose + CUR and VI: β-CYF high dose + CUR. Mice were orally administered their respective doses daily for 21 days. β-CYF caused elevation in AST, ALT, LPO and decline in GPx, CAT and SOD activities. A significant decrease in MI and increase in chromosomal aberrations, TL, TI and TM was recorded in β-CYF exposed groups. CUR co-administration modulated AST, ALT, LPO, GPx, CAT and SOD activity. CUR supplementation improved the MI and reduced the chromosomal aberrations, TL, TI and TM. β-CYF caused serious pathological alterations in liver and these were alleviated by CUR. It is concluded that CUR scavenges ROS and renders a protection against β-CYF genotoxicity.
Environmental Toxicology Laboratory, Department of Zoology, Centre for Advanced Studies, University of Rajasthan, Jaipur, 302004, India. Electronic address: verma.rajbala@gmail.com.
Rajbala
R
Verma
Environmental Toxicology Laboratory, Department of Zoology, Centre for Advanced Studies, University of Rajasthan, Jaipur, 302004, India.
Kumud Kant
KK
Awasthi
Environmental Toxicology Laboratory, Department of Zoology, Centre for Advanced Studies, University of Rajasthan, Jaipur, 302004, India.
Neelu Kanwar
NK
Rajawat
Environmental Toxicology Laboratory, Department of Zoology, Centre for Advanced Studies, University of Rajasthan, Jaipur, 302004, India. Electronic address: inderpalsoni@gmail.com.
Inderpal
I
Soni
Environmental Toxicology Laboratory, Department of Zoology, Centre for Advanced Studies, University of Rajasthan, Jaipur, 302004, India.
P J
PJ
John
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism; D020552:Comet Assay; D003474:Curcumin / Q000494:pharmacology*; D004249:DNA Damage / Q000187:drug effects*; D007306:Insecticides / Q000633:toxicity; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D008111:Liver Function Tests; D008297:Male; D051379:Mice; D009570:Nitriles / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects*; D011722:Pyrethrins / Q000633:toxicity*; D017382:Reactive Oxygen Species
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; D017382:Reactive Oxygen Species; D003474:Curcumin; C052570:cyfluthrin
Chromosomal aberration; Curcumin; DNA damage; Oxidative stress; β-cyfluthrin