Four new taraxastane-type triterpenoic acids from Cirsium setosum.
Four new taraxastane-type triterpenoids acids 3β,22α-dihydroxy-20-taraxasten-30-oic acid (1), 3β-hydroxy-22-oxo-20-taraxasten-30-oic acid (2), 3-oxo-22α-hydroxy-20- taraxasten-30-oic acid (3), and 3β,19β-dihydroxy-20-taraxasten-30-oic acid (4) were isolated and characterized from Cirsium setosum (Willd.) MB. Their structures were determined by the combination of 1D and 2D NMR experiments ((1)H-(1)HCOSY, HSQC, HMBC and ROESY) and mass spectrometry. Compound 2 exhibited potent selective cytotoxicity against human ovarian cancer cell line A2780 with an IC50 value of 3.9 μM.
a Beijing Key Laboratory of Bioactive Substances and Functional Foods , Beijing Union University , Beijing 100191 , China.
Na
N
Luan
a Beijing Key Laboratory of Bioactive Substances and Functional Foods , Beijing Union University , Beijing 100191 , China.
Wen-Di
WD
Wei
a Beijing Key Laboratory of Bioactive Substances and Functional Foods , Beijing Union University , Beijing 100191 , China.
Ali
A
Wang
b College of Pharmacy , Ningxia Medical University , Yinchuan 750004 , China.
Xiu-Li
XL
Wu
c Beijing Municipal Bureau of City Administration and Law Enforcement , Beijing 101500 , China.
Yan
Y
Qi
a Beijing Key Laboratory of Bioactive Substances and Functional Foods , Beijing Union University , Beijing 100191 , China.
Jin-Jie
JJ
Li
a Beijing Key Laboratory of Bioactive Substances and Functional Foods , Beijing Union University , Beijing 100191 , China.
Jian-Quan
JQ
Zheng
a Beijing Key Laboratory of Bioactive Substances and Functional Foods , Beijing Union University , Beijing 100191 , China.
Xiao-Ya
XY
Shang
D031180:Cirsium / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D004365:Drugs, Chinese Herbal; D014315:Triterpenes
Cirsium setosum; Compositae; absolute configuration; cytotoxic activities; taraxastane-type triterpenoids acids