Tipping the Balancing ACT.
Adoptive cell transfer therapy has emerged as a powerful treatment for metastatic melanoma, but efficacy is limited by an inhospitable tumor microenvironment. In this issue of Cancer Cell, Marigo et al. demonstrate that therapy requires induced expression of nitric oxide synthase 2 in monocyte-derived dendritic cells.
Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA; Department of Cutaneous Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA. Electronic address: shari.pilon-thomas@moffitt.org.
Shari
S
Pilon-Thomas
Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA; Department of Breast Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA. Electronic address: brian.ruffell@moffitt.org.
Brian
B
Ruffell
D003713:Dendritic Cells; D006801:Humans; D016219:Immunotherapy, Adoptive; D008545:Melanoma; D052247:Nitric Oxide Synthase Type II; D059016:Tumor Microenvironment
D052247:Nitric Oxide Synthase Type II