Expression patterns of the activator protein-1 (AP-1) family members in lymphoid neoplasms.
The activator protein-1 (AP-1) is a dimeric transcription factor composed of proteins belonging to the Jun (c-Jun, JunB and JunD), Fos (c-Fos, FosB, Fra1 and Fra2) and activating transcription factor protein families. AP-1 is involved in various cellular events including differentiation, proliferation, survival and apoptosis. Deregulated expression of AP-1 transcription factors is implicated in the pathogenesis of various lymphomas such as classical Hodgkin lymphomas, anaplastic large cell lymphomas, diffuse large B cell lymphomas and adult T cell leukemia/lymphoma. The main purpose of this review is the analysis of the expression patterns of AP-1 transcription factors in order to gain insight into the histophysiology of lymphoid tissues and the pathology of lymphoid malignancies.
Department of Pathology, Faculty of Medicine, University of Ioannina, Ioannina, Greece. apapoudoubai@gmail.com.
Alexandra
A
Papoudou-Bai
Department of Hematology, Faculty of Medicine, University of Ioannina, Ioannina, Greece.
Eleftheria
E
Hatzimichael
Department of Anatomy-Histology-Embryology, Faculty of Medicine, University of Ioannina, Ioannina, Greece.
Alexandra
A
Barbouti
Department of Anatomy-Histology-Embryology, Faculty of Medicine, University of Ioannina, Ioannina, Greece. pkanavar@cc.uoi.gr.
Panagiotis
P
Kanavaros
D005786:Gene Expression Regulation; D006801:Humans; D008223:Lymphoma / Q000473:pathology* / Q000503:physiopathology*; D018808:Transcription Factor AP-1 / Q000378:metabolism*
D018808:Transcription Factor AP-1
AP-1; Lymphoid tissues; Lymphomas