Computerized Structured Cognitive Training in Patients Affected by Early-Stage Alzheimer's Disease is Feasible and Effective: A Randomized Controlled Study.
BACKGROUND
Alzheimer's disease (AD) presents with significant neuropsychological deficits. Cognitive training in AD has recently started to demonstrate its efficacy. In this study, we implemented computerized cognitive training of a large group of early-stage AD patients, to identify its effects at a neuropsychological level and to investigate whether they were stable after 6 months.


METHODS
Overall, 80 AD patients were randomized in two groups. Patients in the experimental group used a structured rehabilitative software three times a week for 12 consecutive weeks aimed at training memory, attention, executive function and language skills, whereas patients in the control group underwent a control intervention.


RESULTS
A Repeated Measures General Linear Model considering groups' performance at the three assessment points (before training, after training and at the 6-month follow-up) showed a significant interaction effect for: digit span forward (F(2,74) = 2.785, p = 0.03) and backward (F(2,74) = 3.183, p = 0.02), two-syllable words test (F(2,74) = 3.491, p = 0.004), Rivermead Behavioural Memory Test immediate (F(2,74) = 2.877, p = 0.03) and delayed (F(2,74) = 3.783, p = 0.003), Token test (F(2,74) = 4.783, p = 0.001), and Brixton test (F(2,74) = 8.783, p < 0.001). For all of them, experimental group performed better than controls.


CONCLUSIONS
Patients in the experimental group showed a significant improvement in various neuropsychological domains, and their achievements were stable after 6 months. This study suggests an useful computerized training in AD, and should prompt further investigations about the generalizability of patients' acquired skills to more ecologically oriented tasks.
eCampus University, Novedrate, Como, Italy.|Department of Mental Health , Azienda Sanitaria Locale Torino 3, Collegno, Torino, Italy.|Assisted Health Residence "Ville Roddolo" , Moncalieri, Torino, Italy.
Marco
M
Cavallo
Canterbury Christ Church University, Department of Psychology, Politics and Sociology , Tunbridge Wells, England (UK).
Edyta Monika
EM
Hunter
Leiden University, Department of Psychology, Section Health, Medical and Neuropsychology , Leiden, The Netherlands.
Karin
K
van der Hiele
Assisted Health Residence "Ville Roddolo" , Moncalieri, Torino, Italy.
Chiara
C
Angilletta
Alzheimer's disease; Cognitive training; Memory; Neuropsychology; Rehabilitation