Prevalence and Modifiable Determinants of Non-Adherence in Adult Kidney Transplant Recipients in a German Sample.
OBJECTIVE
The aim of this cross-sectional study was to investigate the prevalence and the modifiable determinants of non-adherence in adult kidney transplant patients in follow-up care.


METHODS
In 74 patients at least six months post-transplant, self-reported adherence (Basel Assessment of Adherence to ImmunosuppressiveMedications Scale, BAASIS©), subjective experience and attitudes after transplantation (Medication Experience Scale for Immunosuppressants, MESI), and depression and anxiety (Hospital Anxiety and Depression Scale,HADSD) were assessed.


RESULTS
Non-adherence to any of the four BAASIS© items was 24.3%. For the sub-dimensions: dose taking, drug holidays, timing deviation more than two hours from prescribed time, and dose reduction, the non-adherence levelswere 9.5%, 0%,17.6% and 2.7%, respectively. Marital status, negative beliefs towards immunosuppressants, and prominent anxiety and depression were associated with non-adherence.


CONCLUSIONS
Screening for adherence and its indicators is of substantial importance in communication with renal transplant recipients. After detecting non-adherence, supportive interventions can be offered to the patients.
Department of Psychosomatic Medicine and Psychotherapy University Hospital of Erlangen Schwabachanlage 6 D-91054 Erlangen Germany http://www.psychosomatik.uk-erlangen.de/
Sandra
S
Reber
Department of Psychosomatic Medicine and Psychotherapy University Hospital of Erlangen Schwabachanlage 6 D-91054 Erlangen Germany http://www.psychosomatik.uk-erlangen.de/
Eva
E
Morawa
Department of Psychosomatic Medicine and Psychotherapy University Hospital of Erlangen Schwabachanlage 6 D-91054 Erlangen Germany http://www.psychosomatik.uk-erlangen.de/
Lisa
L
Stößel
Department of Nephrology and Hypertension University Hospital of Erlangen Ulmenweg 18 91054 Erlangen Deutschland http://www.medizin4.uk-erlangen.de/
Sabine
S
Jank
Department of Psychosomatics and Psychotherapy University Hospital of Cologne Kerpener Str. 62 50937 Köln Deutschland http://psychosomatik-psychotherapie.uk-koeln.de/
Frank
F
Vitinius
Department of Nephrology and Hypertension University Hospital of Erlangen Ulmenweg 18 91054 Erlangen Deutschland http://www.medizin4.uk-erlangen.de/
Kai-Uwe
KU
Eckardt
Department of Psychosomatic Medicine and Psychotherapy University Hospital of Erlangen Schwabachanlage 6 D-91054 Erlangen Germany http://www.psychosomatik.uk-erlangen.de/
Yesim
Y
Erim
D000328:Adult; D000368:Aged; D001521:Behavior Therapy; D003430:Cross-Sectional Studies; D004358:Drug Therapy; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016030:Kidney Transplantation / Q000523:psychology* / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance / Q000523:psychology* / Q000706:statistics & numerical data*; D011795:Surveys and Questionnaires
D007166:Immunosuppressive Agents
Adherence; Anxiety; Compliance; Depression; Health Beliefs; Immunosuppression; Kidney; Renal Transplantation