Treatment of gastric cancer cells with nonthermal atmospheric plasma generated in water.
Nonthermal atmospheric plasma (NTAP) can be applied to living tissues and cells as a novel technology for cancer therapy. The authors report on a NTAP argon solution generated in deionized (DI) water for treating human gastric cancer cells (NCI-N87). Our findings show that the plasma generated in DI water with 30-min duration has the strongest effect on apoptosis in precultured human gastric cancer cells. This result can be attributed to the presence of reactive oxygen species (ROS) and reactive nitrogen species (RNS) produced in water during treatment. Furthermore, the data show that the elevated levels of RNS may play a more significant role than ROS in the rate of cell death.
Department of Mechanical and Aerospace Engineering, The George Washington University, Washington DC 20052.
Zhitong
Z
Chen
Department of Mechanical and Aerospace Engineering, The George Washington University, Washington DC 20052.
Li
L
Lin
Department of Mechanical and Aerospace Engineering, The George Washington University, Washington DC 20052.
Xiaoqian
X
Cheng
Department of Mechanical and Aerospace Engineering, The George Washington University, Washington DC 20052.
Eda
E
Gjika
Department of Mechanical and Aerospace Engineering, The George Washington University, Washington DC 20052.
Michael
M
Keidar
D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis; D001128:Argon / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004847:Epithelial Cells / Q000187:drug effects* / Q000502:physiology*; D006801:Humans; D058626:Plasma Gases; D026361:Reactive Nitrogen Species / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000494:pharmacology; D013997:Time Factors; D014867:Water / Q000494:pharmacology*
D000970:Antineoplastic Agents; D058626:Plasma Gases; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D014867:Water; D001128:Argon