Prognostic value of neglected biomarker in sepsis patients with the old and new criteria: predictive role of lactate dehydrogenase.
This study examined the pH, lactate dehydrogenase (LDH), and heart rate values on the first day of hospitalization in patients with a prediagnosis of sepsis and biomarkers that may predict mortality.



Patients hospitalized in an emergency intensive care unit with a diagnosis of systemic inflammatory response syndrome were classified as having sepsis (n = 28), septic shock (n = 8), or severe sepsis (n = 8) according to International Sepsis Guidelines (old criteria). Forty-four patients were classified as having sepsis (n = 4), septic shock (n = 30), or infection (n = 10) according to The Third International Consensus Definitions for Sepsis and Septic Shock (new criteria). The effects of these patients' laboratory values on survival between groups were compared. Significant values were evaluated by χ2automatic interaction detection analysis.



When the patients were categorized according to the new classification criteria, there was an increase in the number of septic shock patients and a decrease in the number of sepsis patients. In addition, 10 patients were removed from the sepsis category. There was a significant difference between ex and discharged patients in terms of heart rate, pH, sodium bicarbonate, lactate, and LDH (P= .007, P= .002, P= .034, P= .009, and P= .002, respectively). Based on a χ2automatic interaction detection analysis of the significant values, pH, LDH, and heart rate were prominent predictors of prognosis.



Systemic pH, LDH, and heart rate values may be used to determine the best time to discharge patients from intensive care to other, more affordable hospital units.
Department of Emergency Medicine, Adnan Menderes University, Aydin, Turkey.
Ali
A
Duman
Department of Emergency Medicine, Adnan Menderes University, Aydin, Turkey.
Ayhan
A
Akoz
Department of Emergency Medicine, Adnan Menderes University, Aydin, Turkey.
Mucahit
M
Kapci
Department of Biostatistic, Adnan Menderes University, Aydin, Turkey.
Mevlut
M
Ture
Emergency Service, Hitit University, Training and Research Hospital, Corum, Turkey.
Serhat
S
Orun
Emergency Service, Mehmet Akif Training and Research Hospital, Sanliurfa, Turkey.
Kıvanc
K
Karaman
Department of Emergency Medicine, Adnan Menderes University, Aydin, Turkey. Electronic address: drturkdogan@gmail.com.
Kenan Ahmet
KA
Turkdogan
D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D004796:Clinical Enzyme Tests; D005260:Female; D006339:Heart Rate; D006760:Hospitalization; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D019344:Lactic Acid / Q000097:blood; D008297:Male; D017410:Practice Guidelines as Topic; D011237:Predictive Value of Tests; D011379:Prognosis; D018805:Sepsis / Q000175:diagnosis* / Q000503:physiopathology; D012772:Shock, Septic / Q000175:diagnosis / Q000201:enzymology / Q000503:physiopathology; D017693:Sodium Bicarbonate / Q000097:blood; D015996:Survival Rate
D015415:Biomarkers; D019344:Lactic Acid; D017693:Sodium Bicarbonate; D007770:L-Lactate Dehydrogenase