Novel 9, 10-dihydrophenanthrene derivatives from Eria bambusifolia with cytotoxicity aganist human cancer cells in vitro.
The present study was designed to identify bioactive compounds similar to those isolated from Dendrobium genus from its relative specie Eria bambusifolia. Compounds 1-10 were isolated and purified using silica gel, MCI CHP-20 gel, Sephadex LH-20, and Lichroprep RP-18 chromatography methods. Their structures were elucidated by means of extensive spectroscopic analyses. The cytotoxicity of these compounds against five human cancer cell lines was tested. Erathrins A and B (1 and 2) were new compounds, and compound 1 represented a novel carbon framework having a phenanthrene-phenylpropane unit with a dioxane moiety. Moreover, compound 1 showed selective cytotoxic activity against HL-60 cells (IC50 = 14.50 μmol·L(-1)). These results provided a basis for future development of these agents as anticancer lead compounds.
School of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China.
Rui
R
Zhan
School of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China.
Zhi-Chong
ZC
Wang
School of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China.
Ben-Lin
BL
Yin
School of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China.
Ying
Y
Liu
School of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China. Electronic address: ygchen48@126.com.
Ye-Gao
YG
Chen
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects*; D031667:Dendrobium / Q000737:chemistry*; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D010616:Phenanthrenes / Q000737:chemistry* / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D010616:Phenanthrenes; D010936:Plant Extracts; C031181:phenanthrene
9, 10-Dihydrophenanthrene; Cytotoxicity; Erathrins A and B; Eria bambusifolia