Genetic Association of CHAT rs3810950 and rs2177369 Polymorphisms with the Risk of Alzheimer's Disease: A Meta-Analysis.
Choline acetyltransferase (CHAT) rs3810950 and rs2177369 polymorphisms have been implicated in susceptibility to Alzheimer's disease (AD). Due to the inconsistent results from previous studies, a meta-analysis was performed to estimate the association between these polymorphisms and AD risk more precisely. Pooled results of our meta-analysis indicated CHAT rs2177369 polymorphism was correlated with decreasing AD risk in one of five genetic models (dominant: OR = 0.77, 95% CI: 0.62-0.96), while rs3810950 mutant was associated with AD development in three models (allelic: OR = 1.18, 95% CI: 1.01-1.37, homozygous: OR = 1.63, 95% CI: 1.09-2.42, and recessive: OR = 1.65, 95% CI: 1.20-2.26). In subgroup analysis by ethnicity, the association between CHAT rs3810950 polymorphism and AD risk was just found in the recessive model (OR = 1.47, 95% CI: 1.05-2.07) among Caucasians, while four genetic models (allelic: OR = 1.23, 95% CI: 1.01-1.48; homozygous: OR = 2.24, 95% CI: 1.48-3.39; dominant: OR = 1.21, 95% CI: 1.06-1.40; and recessive: OR = 2.18, 95% CI: 1.45-3.29) assumed this association in Asians. In conclusion, our meta-analysis indicated CHAT rs2177369 polymorphism might play a protective role in AD, while rs3810950 variant was a risk factor for AD but its single heterozygous mutations might not influence susceptibility to AD.
Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, Guangdong 523808, China; School of Pharmacy, Guangdong Medical University, Dongguan, Guangdong 523808, China; Key Laboratory for Research and Development of Natural Drugs of Guangdong Province, Zhanjiang, Guangdong 524023, China.
Yong
Y
Liu
Department of Biochemistry and Molecular Biology, Guangxi Medical University, Nanning, Guangxi 530021, China.
Qicong
Q
Chen
Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, Guangdong 523808, China; The Second School of Clinical Medicine, Guangdong Medical University, Dongguan 523808, China.
Xu
X
Liu
Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, Guangdong 523808, China; Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, Guangdong 523808, China.
Mengmeng
M
Dou
School of Basic Medicine, Guangdong Medical University, Dongguan, Guangdong 523808, China.
Silu
S
Li
Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, Guangdong 523808, China; Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, Guangdong 523808, China.
Jiahui
J
Zhou
School of Pharmacy, Guangdong Medical University, Dongguan, Guangdong 523808, China.
Hong
H
Liu
Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, Guangdong 523808, China; Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524023, China.
Yongfu
0000-0002-1245-251X
Y
Wu
Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, Guangdong 523808, China; School of Pharmacy, Guangdong Medical University, Dongguan, Guangdong 523808, China; Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, Guangdong 523808, China.
Zunnan
0000-0002-5821-703X
Z
Huang
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000235:genetics*; D002795:Choline O-Acetyltransferase / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies / Q000379:methods; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D012307:Risk Factors
D005819:Genetic Markers; D002795:Choline O-Acetyltransferase