Efficacy and safety of oral triclofos as sedative for children undergoing sleep electroencephalogram: An observational study.
OBJECTIVE
Triclofos may be a better sedative in view of better palatability and less gastric irritation as compared to chloral hydrate. This study aimed to assess the efficacy of triclofos (a commonly used sedative in India) as a sedative for sleep electroencephalogram (EEG) study in children.


METHODS
This prospective observational study was carried out in a tertiary care pediatric center. Consecutive children aged 6 months to 5 years referred for sleep EEG evaluation were recruited. Their clinical details were noted in a proforma after an informed consent. After a trial for natural sleep, oral triclofos was administered. Sleep parameters and adverse effects were noted.


RESULTS
One-hundred and sixty children were then enrolled. EEG was successfully recorded in 149 (93.1%) children. Median latency of sleep onset was 30 min and median duration of sleep was 90 min. The adverse effects in the following 24 h were mild and included dizziness, irritability, and vomiting.


CONCLUSIONS
Oral triclofos was found to be an effective sedative for EEG in children with minimal adverse effects.
Department of Neonatal, Pediatric and Adolescent Medicine, Division of Pediatric Neurology, BLK Super Speciality Hospital, New Delhi, India.
Puneet
P
Jain
Department of Pediatrics, Division of Pediatric Neurology, Lady Hardinge Medical College and Associated Kalawati Saran Children Hospital, New Delhi, India.
Suvasini
S
Sharma
Department of Pediatrics, Division of Pediatric Neurology, Lady Hardinge Medical College and Associated Kalawati Saran Children Hospital, New Delhi, India.
Ankita
A
Sharma
Department of Pediatrics, Division of Pediatric Neurology, Lady Hardinge Medical College and Associated Kalawati Saran Children Hospital, New Delhi, India.
Shaiphali
S
Goel
Department of Pediatrics, Division of Pediatric Neurology, Lady Hardinge Medical College and Associated Kalawati Saran Children Hospital, New Delhi, India.
Anjali
A
Jose
Department of Pediatrics, Division of Pediatric Neurology, Lady Hardinge Medical College and Associated Kalawati Saran Children Hospital, New Delhi, India.
Satinder
S
Aneja
Electroencephalogram; epilepsy; sedation; triclofos