Emerging role of epithelial-mesenchymal transition in hepatic cancer.
Accumulating evidence suggests that the phenomenon of epithelial-mesenchymal-transition (EMT) plays a fundamental role in the tumor development. Several research articles have been published from Journal of Experimental and Clinical Cancer Research (JECCR) which have investigated into the molecular machineries underlying the importance of EMT for hepatic cancer. Given those recent publications by JECCR, this commentary focuses on the pathological significance of EMT for liver tumor.
Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan. medical21go@yahoo.co.jp.|Japan Society for the Promotion of Science, 5-3-1 Kojimachi, Chiyoda-ku, Tokyo, 102-0083, Japan. medical21go@yahoo.co.jp.
Go J
GJ
Yoshida
D058750:Epithelial-Mesenchymal Transition; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology*; D060449:Wnt Signaling Pathway
Cancer stem-like cells; Cirrhosis; Epithelial-mesenchymal transition; Hepatic cancer; Matrix metalloproteinases; Wnt/beta-catenin signal