Associations of Rs3744841 and Rs3744843 Polymorphisms in Endothelial Lipase Gene with Risk of Coronary Artery Disease and Lipid Levels in a Chinese Population.
OBJECTIVE
The aim of the present study was to assess the association between the 2037T/C and 2237G/A polymorphisms in the EL gene and the risk of CAD and lipid levels in a Chinese population.


METHODS
A case-control study including 706 patients with CAD and 315 controls was performed. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to identify the genotypes.


RESULTS
The EL 2037 T/C polymorphism was associated with CAD risk and HDL-C levels. No significant differences were found between the EL 2237 G/A genotypes and CAD risk and lipid levels in the whole population. However, carriers of the 2237 A allele had higher Apo A1 levels than those with the 2237 GG genotype and in the CAD subgroup (P = 0.044). The CAD cases have a significantly lower frequency of the C-G haplotypes than the controls, and the T-A haplotype was significantly more common in the CAD patients than in the controls.


CONCLUSIONS
Our study concluded that the EL 2037 T/C polymorphism was associated with CAD risk and HDL-C levels, and that the C allele might be a protective factor against CAD in the Chinese Han population. In addition, the EL 2237 A allele might be associated with an increased Apo A1 level in CAD subjects.
Department of Cardiology, Wujin hospital affiliated to Jiangsu University, Changzhou, Jiangsu Province, China.
Gaojun
G
Cai
Department of Pathology and Molecular Medicine, McMaster University, Ontario, Canada.
Bifeng
B
Zhang
Department of Cardiology, Wujin hospital affiliated to Jiangsu University, Changzhou, Jiangsu Province, China.
Chunyan
C
Ma
Department of Cardiology, Wujin hospital affiliated to Jiangsu University, Changzhou, Jiangsu Province, China.
Ganwei
G
Shi
Department of Cardiology, Wujin hospital affiliated to Jiangsu University, Changzhou, Jiangsu Province, China.
Weijin
W
Weng
Department of Cardiology, Wujin hospital affiliated to Jiangsu University, Changzhou, Jiangsu Province, China.
Sheliang
S
Xue
D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000201:enzymology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008049:Lipase / Q000235:genetics*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D012720:Severity of Illness Index
D008055:Lipids; C410382:LIPG protein, human; D008049:Lipase