Mucosal and cutaneous human papillomaviruses in head and neck squamous cell papillomas.
Conflicting data exist regarding the contribution of human papillomavirus (HPV) to the development of head and neck squamous cell papillomas.



Formalin-fixed paraffin-embedded papillomas were tested for 28 mucosal and 79 cutaneous HPVs using polymerase chain reaction (PCR)-based methods.



Eighty-three papillomas (43 oropharyngeal, 31 oral, 6 laryngeal, and 3 nasopharyngeal) were analyzed. Twenty-four samples (28.9%) harbored mucosal HPVs: 3 oropharyngeal (6.9%), 15 oral (48.3%), 4 laryngeal (66.7%), and 2 nasopharyngeal papillomas (66.7%). Eighty-one cases were also tested for cutaneous HPVs, detected in 16 lesions (19.7%): 11 (13.5%) harbored only cutaneous types, and 5 (6.2%) were positive for both cutaneous and mucosal HPVs. Among these 81 cases, prevalence of mucosal and/or cutaneous HPV infection was 43.2%.



HPV DNA detection in a fraction of head and neck papillomas supports the role of HPV in their development. However, other markers need to be considered to confirm the association of HPV infection with these lesions. © 2016 Wiley Periodicals, Inc. Head Neck 39: 254-259, 2017.
STI/HIV Unit, San Gallicano Dermatologic Institute, IRCCS, Rome, Italy.
Maria Gabriella
0000-0003-3250-1726
MG
Donà
Otolaryngology Head Neck Surgery Department, Regina Elena National Cancer Institute, IRCCS, Rome, Italy.
Barbara
B
Pichi
Pathology Department, Regina Elena National Cancer Institute, IRCCS, Rome, Italy.
Francesca
F
Rollo
Infections and Cancer Biology Group, International Agency for Research on Cancer, Lyon, France.
Tarik
T
Gheit
Pathology Department, Regina Elena National Cancer Institute, IRCCS, Rome, Italy.
Valentina
V
Laquintana
Pathology Department, Regina Elena National Cancer Institute, IRCCS, Rome, Italy.
Renato
R
Covello
Pathology Department, Regina Elena National Cancer Institute, IRCCS, Rome, Italy.
Edoardo
E
Pescarmona
Otolaryngology Head Neck Surgery Department, Regina Elena National Cancer Institute, IRCCS, Rome, Italy.
Giuseppe
G
Spriano
Otolaryngology Head Neck Surgery Department, Regina Elena National Cancer Institute, IRCCS, Rome, Italy.
Raul
R
Pellini
STI/HIV Unit, San Gallicano Dermatologic Institute, IRCCS, Rome, Italy.
Massimo
M
Giuliani
Infections and Cancer Biology Group, International Agency for Research on Cancer, Lyon, France.
Massimo
M
Tommasino
Pathology Department, Regina Elena National Cancer Institute, IRCCS, Rome, Italy.
Maria
M
Benevolo
D000328:Adult; D001707:Biopsy, Needle; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000821:virology*; D016208:Databases, Factual; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology* / Q000821:virology*; D061809:Human Papillomavirus DNA Tests / Q000379:methods; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology / Q000821:virology; D010212:Papilloma / Q000473:pathology* / Q000821:virology; D027383:Papillomaviridae / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000473:pathology*; D016612:Paraffin Embedding; D016133:Polymerase Chain Reaction / Q000379:methods; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012867:Skin / Q000473:pathology / Q000821:virology; D000077195:Squamous Cell Carcinoma of Head and Neck
oral cavity; oropharynx; papilloma; papillomavirus; prevalence