B7-H3 Overexpression Predicts Poor Survival of Cancer Patients: A Meta-Analysis.
BACKGROUND
B7-H3 exhibits altered expression in various cancers. However, the correlation between B7-H3 expression and prognosis of cancer patients remains controversial. Therefore, we elicit a meta-analysis to investigate the potential value of B7-H3 in the prognostic prediction in human cancers.


METHODS
We searched PubMed (last update by June 15th, 2016) to identify studies assessing the effect of B7-H3 on survival of cancer patients. Hazard ratios (HRs) for overall survival (OS), recurrence free survival (RFS) and progression-free survival (PFS) from individual studies were calculated and pooled by using a random-effect or fix-effect model, and heterogeneity and publication bias analyses were also performed.


RESULTS
Data from 24 observational studies consisting of 4141 patients were summarized. An elevated baseline B7-H3 was significantly correlated with poor OS (pooled HR = 2.09; 95% CI =1.60-2.74; P < 0.001). Differences across subgroups of tumor type (P = 0.324), year of publication (P = 0.431), ethnicity (P = 0.940), source of HR (P = 0.145), analysis type (P = 0.178) and sample size (P = 0.909) were not significant. Furthermore, high B7-H3 expression also predicted a significantly poor RFS (pooled HR = 1.39; 95% CI = 1.11-1.75; P = 0.004) but not PFS.


CONCLUSIONS
This meta-analysis clarifies that elevated B7-H3 expression is significantly associated with poor survival in cancer patients.
Department of Orthopedics, The Sixth Hospital of Ningbo, Ningbo, China.
Zhimeng
Z
Ye
Zhuojun
Z
Zheng
Xiaodong
X
Li
Yuandong
Y
Zhu
Zhaoping
Z
Zhong
Linrui
L
Peng
Yanyan
Y
Wu
D060887:B7 Antigens / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000235:genetics*; D015870:Gene Expression; D006801:Humans; D053208:Kaplan-Meier Estimate; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D016016:Proportional Hazards Models
D060887:B7 Antigens; D014408:Biomarkers, Tumor; C423237:CD276 protein, human