Go ahead, grow a head! A planarian's guide to anterior regeneration.
The unique ability of some planarian species to regenerate a head de novo, including a functional brain, provides an experimentally accessible system in which to study the mechanisms underlying regeneration. Here, we summarize the current knowledge on the key steps of planarian head regeneration (head-versus-tail decision, anterior pole formation and head patterning) and their molecular and cellular basis. Moreover, instructive properties of the anterior pole as a putative organizer and in coordinating anterior midline formation are discussed. Finally, we highlight that regeneration initiation occurs in a two-step manner and hypothesize that wound-induced and existing positional cues interact to detect tissue loss and together determine the appropriate regenerative outcomes.
Max Planck Research Group Stem Cells and Regeneration Max Planck Institute for Molecular Biomedicine Von-Esmarch-Str. 5448149 Münster Germany; Medical Faculty University of Münster Albert-Schweitzer-Campus 148149 Münster Germany; CiM-IMPRS Graduate School Schlossplatz 548149 Münster Germany.
Suthira
S
Owlarn
Max Planck Research Group Stem Cells and Regeneration Max Planck Institute for Molecular Biomedicine Von-Esmarch-Str. 5448149 Münster Germany; Medical Faculty University of Münster Albert-Schweitzer-Campus 148149 Münster Germany.
Kerstin
K
Bartscherer
Organizer; Wnt; patterning; planaria; polarity; regeneration; wound