Depression-like behaviors and heme oxygenase-1 are regulated by Lycopene in lipopolysaccharide-induced neuroinflammation.
Previous studies have demonstrated that lycopene possesses anti-inflammatory properties in the central nervous system. However, the potential role and the molecular mechanisms of lycopene in lipopolysaccharide (LPS)-challenge inflammation and depression-like behaviors has not been clearly investigated. The present study aimed to assess the effects and the potential mechanisms of lycopene on LPS-induced depression-like behaviors. Lycopene was orally administered (60mg/kg) every day for seven days followed by intraperitoneal LPS injection (1mg/kg). The Forced swim test and tail suspension test were used to detect changes in the depression-like behaviors. ELISA was used to measure the expression of interleukin-6 (IL-6) and tumor necrosis factor-α(TNF-α) in the plasma. Immunoblotting was performed to measure the expression of interleukin-1β (IL-1β) and heme oxygenase-1 (HO-1) in the hippocampus. The results showed that pretreatment with lycopene could ameliorate depression-like behaviors. Moreover, lycopene relieved neuronal cell injury in hippocampal CA1 regions. Furthermore, lycopene decreased LPS-induced expression of IL-1β and HO-1 in the hippocampus together with decreasing level of IL-6 and TNF-α in the plasma. Taken together, these results suggest that lycopene can attenuate LPS-induced inflammation and depression-like behaviors, which may be involved in regulating HO-1 in the hippocampus.
Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical University, Xuzhou, Jiangsu 221004, PR China; Laboratory of Morphology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, PR China.
Fang
F
Zhang
Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical University, Xuzhou, Jiangsu 221004, PR China.
Yanyan
Y
Fu
Laboratory of Morphology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, PR China.
Xiaoyan
X
Zhou
Department of Pathogen Biology and Immunology, Laboratory of Infection and Immunity, Xuzhou Medical University, Xuzhou, Jiangsu 221004, PR China.
Wei
W
Pan
School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu 221004, PR China.
Yue
Y
Shi
Laboratory of Morphology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, PR China.
Mei
M
Wang
School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu 221004, PR China.
Xunbao
X
Zhang
Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical University, Xuzhou, Jiangsu 221004, PR China.
Dashi
D
Qi
Department of Geratology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, PR China.
Lei
L
Li
Department of Medical Information, Xuzhou Medical University, Xuzhou, Jiangsu 221004, PR China.
Kai
K
Ma
Laboratory of Morphology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, PR China; Department of Pathogen Biology and Immunology, Laboratory of Infection and Immunity, Xuzhou Medical University, Xuzhou, Jiangsu 221004, PR China.
Renxian
R
Tang
Laboratory of Morphology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, PR China; Department of Pathogen Biology and Immunology, Laboratory of Infection and Immunity, Xuzhou Medical University, Xuzhou, Jiangsu 221004, PR China. Electronic address: zky02@163.com.
Kuiyang
K
Zheng
Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical University, Xuzhou, Jiangsu 221004, PR China; Department of Genetics, Research Center for Neurobiology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, PR China. Electronic address: biosongyuanjian@126.com.
Yuanjian
Y
Song
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002338:Carotenoids / Q000627:therapeutic use*; D003863:Depression / Q000097:blood / Q000188:drug therapy* / Q000209:etiology*; D004660:Encephalitis / Q000139:chemically induced / Q000150:complications*; D004797:Enzyme-Linked Immunosorbent Assay; D005786:Gene Expression Regulation / Q000187:drug effects; D051547:Heme Oxygenase-1 / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood; D008070:Lipopolysaccharides / Q000633:toxicity; D000077276:Lycopene; D051379:Mice; D008813:Mice, Inbred ICR; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D000975:Antioxidants; D015850:Interleukin-6; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D002338:Carotenoids; D051547:Heme Oxygenase-1; D000077276:Lycopene
Heme oxygenase-1; Hippocampus; Interleukin-1β; Lipopolysaccharide; Lycopene