Layered nanohydroxyapatite as a novel nanocarrier for controlled delivery of 5-fluorouracil.
Layered materials intercalated by drug molecules have attracted much attention since they exhibit improved safety and effectiveness in drug delivery. In this work, layered nanohydroxyapatite (L-nHAp) was synthesized by template method and a model anticancer drug 5-fluorouracil (5FU) was loaded by intercalation technique. The morphology and structure of L-nHAp/5FU hybrids were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). XRD and FTIR revealed the successful drug intercalation into the gallery of L-nHAp. TGA evidenced enhanced thermal stability of the drug molecules in the gallery of L-nHAp. The in vitro release experiments demonstrated that the release of 5FU from L-nHAp/5FU was slower than that from rodlike nanohydroxyapatite (R-nHAp)/5FU. Furthermore, the release of 5FU from L-nHAp/5FU hybrid could be fitted by first-order, Higuchi, and Rigter-Pappas models. It is believed that L-nHAp may be a promising carrier for anticancer drugs.
School of Materials Science and Engineering, East China Jiaotong University, Nanchang 330013, China; School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China.
Honglin
H
Luo
School of Materials Science and Engineering, East China Jiaotong University, Nanchang 330013, China.
Dehui
D
Ji
School of Materials Science and Engineering, East China Jiaotong University, Nanchang 330013, China.
Chunzhi
C
Li
School of Chemical Engineering, Tianjin University, Tianjin 300072, China.
Yong
Y
Zhu
School of Materials Science and Engineering, East China Jiaotong University, Nanchang 330013, China; School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China. Electronic address: xiongguangyao@163.com.
Guangyao
G
Xiong
School of Materials Science and Engineering, East China Jiaotong University, Nanchang 330013, China; School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China. Electronic address: yzwantju@126.com.
Yizao
Y
Wan
D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D065546:Drug Liberation; D004355:Drug Stability; D017886:Durapatite / Q000737:chemistry*; D005472:Fluorouracil / Q000008:administration & dosage* / Q000737:chemistry; D007700:Kinetics; D008962:Models, Theoretical; D053758:Nanoparticles; D013696:Temperature
D000964:Antimetabolites, Antineoplastic; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D017886:Durapatite; D005472:Fluorouracil
5-Fluorouracil; Controlled release; Intercalation; Layered hydroxyapatite