Relationship between grip strength and newly diagnosed nonalcoholic fatty liver disease in a large-scale adult population.
Enhanced muscle strength is often related to improved insulin sensitivity and secretion, control of lipid metabolism, and increased secretion of myokines. These factors have emerged as important mechanisms involved in the development and progression of nonalcoholic fatty liver disease (NAFLD), implying that muscle strength may be a useful predictor for NAFLD. We aimed to assess the relationship between grip strength (GS) and NAFLD in a large-scale adult population. GS was assessed using an electronic hand-grip dynamometer, and NAFLD was diagnosed by the liver ultrasonography. Multiple logistic regression analysis was used to assess the relationship between the quartiles of GS per body weight and the prevalence of NAFLD. After adjusting for potentially confounding factors, the odds ratios (95% confidence interval) for overall NAFLD, NAFLD with normal alanine aminotransferase levels, and NAFLD with elevated alanine aminotransferase levels across the quartiles of GS were 1.00 (reference), 0.89 (0.78, 1.01), 0.77 (0.67, 0.89), and 0.67 (0.57, 0.79); 1.00 (reference), 0.91 (0.80, 1.04), 0.79 (0.68, 0.92), and 0.72 (0.61, 0.85); 1.00 (reference), 0.77 (0.61, 0.98), 0.67 (0.51, 0.86), and 0.53 (0.40, 0.71) (all P for trend < 0.01), respectively. This is the first study shows that increased GS is independently associated with lower prevalence of NAFLD.
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.|Collaborative Innovation Center of Non-communicable Disease, Tianjin Medical University, Tianjin, China.
Ge
G
Meng
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.|Collaborative Innovation Center of Non-communicable Disease, Tianjin Medical University, Tianjin, China.
Hongmei
H
Wu
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.
Liyun
L
Fang
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.
Chunlei
C
Li
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.
Fei
F
Yu
Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China.
Qing
Q
Zhang
Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China.
Li
L
Liu
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.
Huanmin
H
Du
Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China.
Hongbin
H
Shi
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.|Collaborative Innovation Center of Non-communicable Disease, Tianjin Medical University, Tianjin, China.
Yang
Y
Xia
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.
Xiaoyan
X
Guo
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.
Xing
X
Liu
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.|Collaborative Innovation Center of Non-communicable Disease, Tianjin Medical University, Tianjin, China.
Xue
X
Bao
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.
Qian
Q
Su
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.
Yeqing
Y
Gu
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.
Huijun
H
Yang
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.
Bin Yu
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.
Yuntang
Y
Wu
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.
Zhong
Z
Sun
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.|Collaborative Innovation Center of Non-communicable Disease, Tianjin Medical University, Tianjin, China.|Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China.
Kaijun
K
Niu
D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D018737:Hand Strength; D006801:Humans; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000175:diagnosis / Q000503:physiopathology*; D011446:Prospective Studies