Sigmoid-vaginal fistula during bevacizumab treatment diagnosed by fistulography.
OBJECTIVE
There have been several reports describing rectovaginal fistula development after bevacizumab treatment, and these fistulas were diagnosed by CT scan or colonoscopy. We report a case of sigmoid-vaginal fistula diagnosed by fistulography.


METHODS
The case is a 53-year-old woman who was treated for chronic myelogenous leukaemia and gynaecological cancers 8 years previously. At 52 years of age, she was diagnosed with colon cancer and had a partial colectomy performed. One year after surgery, colon cancer recurred, and she was treated with anticancer agents, including bevacizumab. During chemotherapy, she complained of a foul smelling discharge from the vagina. Fistulography revealed a sigmoid-vaginal fistula.


CONCLUSIONS
This is the first report of vaginal fistulography performed on a patient who was treated with bevacizumab. Fistulography may be useful for detecting sigmoid-vaginal fistula.
Department of Obstetrics and Gynecology, Nihon University School of Medicine, Tokyo, Japan. hayashi.chuyu@nihon-u.ac.jp.
C
C
Hayashi
Department of Obstetrics and Gynecology, Nihon University School of Medicine, Tokyo, Japan.
S
S
Takada
Department of Obstetrics and Gynecology, Nihon University School of Medicine, Tokyo, Japan.
A
A
Kasuga
Department of Obstetrics and Gynecology, Nihon University School of Medicine, Tokyo, Japan.
K
K
Shinya
Department of Digestive Surgery, Nihon University School of Medicine, Tokyo, Japan.
M
M
Watanabe
Department of Digestive Surgery, Nihon University School of Medicine, Tokyo, Japan.
H
H
Kano
Department of Digestive Surgery, Nihon University School of Medicine, Tokyo, Japan.
T
T
Takayama
D020533:Angiogenesis Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D000068258:Bevacizumab / Q000009:adverse effects* / Q000627:therapeutic use; D012809:Colon, Sigmoid / Q000187:drug effects*; D003110:Colonic Neoplasms / Q000188:drug therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D014624:Vaginal Fistula / Q000139:chemically induced*
D020533:Angiogenesis Inhibitors; D000068258:Bevacizumab
bevacizumab; fistulography; sigmoid-vaginal fistula