Effects of annual influenza vaccination on mortality in patients with heart failure.
The objective was to evaluate the effect of influenza vaccine on all-cause mortality in a cohort of patients with heart failure followed up in primary care centres of the Community of Madrid, Spain, during the period 2006-10. Results of the Cox proportional-hazard model were adjusted for age and sex and, after 1:1 nearest neighbour matching, for propensity score. The analysis was further stratified by season. Having received annual influenza vaccine was associated with a decreased risk of death during the influenza season (hazard ratio = 0.59, 95% CI = 0.41-0.84), but no protective effect was observed before or after the influenza season.
Agency for Health Technology Assessment, Institute of Health Carlos III, Madrid, Spain vendula.novakova@salud.madrid.org.
Vendula
V
Blaya-Nováková
Agency for Health Technology Assessment, Institute of Health Carlos III, Madrid, Spain.
Francisco J
FJ
Prado-Galbarro
Agency for Health Technology Assessment, Institute of Health Carlos III, Madrid, Spain.|Department of Surgery, Medical and Social Sciences, University of Alcalá, Alcalá de Henares, Spain.|Health Services Research on Chronic Patients Network REDISSEC, Madrid, Spain.
Antonio
A
Sarría-Santamera
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002423:Cause of Death; D015331:Cohort Studies; D005260:Female; D006333:Heart Failure / Q000209:etiology* / Q000401:mortality*; D006801:Humans; D007252:Influenza Vaccines / Q000627:therapeutic use*; D007251:Influenza, Human / Q000150:complications* / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012621:Seasons; D013030:Spain; D014611:Vaccination / Q000706:statistics & numerical data*
D007252:Influenza Vaccines