Synthesis, Biological Evaluation and Docking Analysis of Some Novel Quinazolin Derivatives as Antitumor Agents.
Different acid chlorides (2a-d) reacted with anthranilic acid to produce 2-substituted-3, 1-benzoxazin-4-one (3a-d) which was used as starting material to synthesize some condensed and non-condensed heterocyclic compounds by reaction with nitrogen nucleophiles e.g., hydrazine hydrate, and formamide. Some of the newly synthesized analogues were chosen to evaluate their cytotoxic activity against human carcinoma cell lines (HePG2- MCF7- A549). The docking and the cytotoxic activity results revealed that nearly all of the compounds containing N-phenyl aniline showed signiﬁcant inhibition for the three cell lines.
Therapeutical Chemistry Department, National Research Center, Dokki, Cairo, Egypt.
Walaa S
WS
El-Serwy
Therapeutical Chemistry Department, National Research Center, Dokki, Cairo, Egypt.
Neama
N
A Mohamed
Therapeutical Chemistry Department, National Research Center, Dokki, Cairo, Egypt.
Emad
E
M M Kassem
Department of Pharmacognosy, National Research Center, Cairo, Egypt.
Khaled
K
Mahmoud
Department of Pharmacognosy, National Research Center, Cairo, Egypt.
M M
MM
Mounier
Antitumor; Benzoxazin; Cytotoxic activity; Docking analysis; Quinazolin