Diagnostic significance of IL-6 and IL-8 in tubal ectopic pregnancy.
As there are no specific non-invasive markers for the diagnosis of tubal ectopic pregnancy, our objective in the present study was to explore the role of inflammatory cytokines IL-6 and IL-8 in the diagnosis of ruptured tubal ectopic pregnancy. Twenty-eight women with tubal ectopic pregnancy, 31 patients with intrauterine abortion and 29 gestational age matched women having normal intrauterine pregnancy were included in the study. Five millilitre of blood was collected at the time of admission, serum was separated and stored at -70 °C for subsequent analysis of β hCG, IL-6 and IL-8 levels. The level of IL-6 was a significant increase in the women with tubal ectopic pregnancy compared to intrauterine abortion and normal pregnancy. IL-8 levels decrease significantly in the tubal ectopic pregnancy and in intrauterine abortion patients when compared with the normal pregnancy group. At the cutoff of 26.48 pg/ml IL-6 level predicted the tubal ectopic pregnancy with moderate accuracy. Therefore, it can be concluded that measurement of IL-6 may have relevance in the diagnosis of ectopic pregnancy as a novel inflammatory serum biomarkers.
a Department of Biochemistry , Jawaharlal Institute of Post-Graduate Medical Education and Research (JIPMER) , Puducherry , India.
Soundravally
S
Rajendiran
a Department of Biochemistry , Jawaharlal Institute of Post-Graduate Medical Education and Research (JIPMER) , Puducherry , India.
G P
GP
Senthil Kumar
a Department of Biochemistry , Jawaharlal Institute of Post-Graduate Medical Education and Research (JIPMER) , Puducherry , India.
Archana
A
Nimesh
a Department of Biochemistry , Jawaharlal Institute of Post-Graduate Medical Education and Research (JIPMER) , Puducherry , India.
Pooja
P
Dhiman
a Department of Biochemistry , Jawaharlal Institute of Post-Graduate Medical Education and Research (JIPMER) , Puducherry , India.
K
K
Shivaraman
b Department of Obstetrics and Gynaecology , Jawaharlal Institute of Post-Graduate Medical Education and Research (JIPMER) , Puducherry , India.
S
S
Soundararaghavan
D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007194:India; D007249:Inflammation / Q000097:blood; D015850:Interleukin-6 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D011247:Pregnancy; D011274:Pregnancy, Tubal / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology; D015203:Reproducibility of Results
D015415:Biomarkers; D015850:Interleukin-6; D016209:Interleukin-8
Ectopic; inflammation; interleukins; tubal