APOBEC3 deletion increases the risk of breast cancer: a meta-analysis.
Recently, a deletion in the human apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) gene cluster has been associated with a modest increased risk of breast cancer, but studies yielded inconsistent results. Therefore we performed a meta-analysis to derive a more precise conclusion. Six studies including 18241 subjects were identified by searching PubMed and Embase databases from inception to April 2016. Pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were evaluated under allele contrast, dominant, recessive, homozygous, and heterozygous models. All the analyses suggested a correlation of APOBEC3 deletion with increased breast cancer risk (D vs I: OR = 1.29, 95% CI = 1.23-1.36; D/D+I/D vs I/I: OR = 1.34, 95% CI = 1.26-1.43; D/D vs I/D+ I/I: OR = 1.51, 95% CI = 1.36-1.68; D/D vs I/I: OR = 1.75, 95% CI= 1.56-1.95; I/D vs I/I: OR = 1.28, 95% CI = 1.19-1.36). Stratified analysis by ethnicity showed that the relationship is stronger and more stable in Asians. In summary, our current work indicated that APOBEC3 copy number variations might have a good screening accuracy for breast cancer.
Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, 250013, China.
Yali
Y
Han
Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, Jinan, 250012, China.
Qichao
Q
Qi
Department of Endocrine and Metabolism, Qilu Hospital of Shandong University, Jinan, 250012, China.
Qin
Q
He
Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, 250013, China.
Meili
M
Sun
Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, 250013, China.
Shuyun
S
Wang
Department of General Surgery, Qilu Hospital of Shandong University, Jinan, 250012, China.
Guanzhou
G
Zhou
Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, 250013, China.
Yuping
Y
Sun
D000071478:APOBEC Deaminases; D001943:Breast Neoplasms / Q000235:genetics*; D003564:Cytidine Deaminase; D043525:Cytosine Deaminase / Q000235:genetics*; D056915:DNA Copy Number Variations; D005260:Female; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D054643:INDEL Mutation; D016017:Odds Ratio; D017594:Publication Bias; D012306:Risk
D043525:Cytosine Deaminase; D000071478:APOBEC Deaminases; C502889:APOBEC3 proteins, human; D003564:Cytidine Deaminase
APOBEC3; breast cancer; cancer susceptibility; copy number variation