Bioactive phenols as potential neuroinflammation inhibitors from the leaves of Xanthoceras sorbifolia Bunge.
Xanthoceras sorbifolia Bunge is a medicinal plant and also a valuable cash crop used for production of edible oil and biofuels in China. In our previous research, systematical phytochemical and bioactive profiles of different parts from X. sorbifolia have been obtained. Here we describe the effective phenols from the leaves of X. sorbifolia, which could function as natural neuroinflammation inhibitors. As a result, 23 compounds were characterized as the phenols from the leaves of X. sorbifolia by means of chromatographical methods and spectroscopic analysis. Among them, flavonoids quercetin3-O-β-d-glucopyarnoside (IC5013.39±1.27μM), catechin (IC509.52±2.18μM), and phenylpropanoids syringaresinol-4-O-β-d-glucopyranoside (IC503.08±1.77μM), 4-O-β-d-glucopyranosyl-trans-p-coumaric acid (IC509.08±1.23μM) exhibited much stronger inhibiting effect on NO production than that of the positive control minocycline (IC5037.04±2.09μM) in LPS-induced BV2 cells.
School of Traditional Chinese Materia Medica 49(#), Shenyang Pharmaceutical University, Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Wenhua Road 103, Shenyang 110016, China.
Ning
N
Li
School of Traditional Chinese Materia Medica 49(#), Shenyang Pharmaceutical University, Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Wenhua Road 103, Shenyang 110016, China.
Ying
Y
Wang
Department of Pharmacy, Affiliated Hospital of Yanbian University, Yanji 133000, China.
Xuezheng
X
Li
School of Traditional Chinese Materia Medica 49(#), Shenyang Pharmaceutical University, Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Wenhua Road 103, Shenyang 110016, China.
Hong
H
Zhang
School of Traditional Chinese Materia Medica 49(#), Shenyang Pharmaceutical University, Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Wenhua Road 103, Shenyang 110016, China.
Di
D
Zhou
School of Traditional Chinese Materia Medica 49(#), Shenyang Pharmaceutical University, Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Wenhua Road 103, Shenyang 110016, China.
Wenli
W
Wang
School of Functional Food and Red Wine, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China.
Wei
W
Li
School of Functional Food and Red Wine, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China.
Xiangrong
X
Zhang
Department of Endocrinology, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian 116033, China. Electronic address: dlxinyuli1969@163.com.
Xinyu
X
Li
College of Life and Health Sciences, Department of Biochemistry and Molecular Biology, Northeastern University, Shenyang 110819, China. Electronic address: houyue@mail.neu.edu.cn.
Yue
Y
Hou
School of Traditional Chinese Materia Medica 49(#), Shenyang Pharmaceutical University, Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Wenhua Road 103, Shenyang 110016, China. Electronic address: mengdl@163.com.
Dali
D
Meng
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D004660:Encephalitis / Q000517:prevention & control*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D029631:Sapindaceae / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
D000893:Anti-Inflammatory Agents; D010636:Phenols; D010936:Plant Extracts
LPS; Leaves; Microglia; Neurodegenerative diseases; Neuroinflammatory inhibitors; Xanthoceras sorbifolia Bunge