Stem cell regenerative potential for plastic and reconstructive surgery.
Stem cells represent heterogeneous population of undifferentiated cells with unique characteristics of long term self renewal and plasticity. Moreover, they are capable of active migration to diseased tissues, secretion of different bioactive molecules, and they have immunosuppressive potential as well. They occur in all tissues through life and are involved in process of embryogenesis and regeneration. During last decades stem cells attracted significant attention in each field of medicine, including plastic and reconstructive surgery. The main goal of the present review article is to present and discuss the potential of stem cells and to provide information about their safe utilization in chronic wounds and fistulae healing, scar management, breast reconstruction, as well as in bone, tendon and peripheral nerve regeneration.
Department of Plastic, Reconstructive and Aesthetic Surgery, Faculty of Medicine, Comenius University in Bratislava and University Hospital, Pažítkova 4, 826 06, Bratislava, Slovakia. bohac.md@gmail.com.
Martin
http://orcid.org/0000-0003-4625-1326
M
Boháč
Institute of Histology and Embryology, Faculty of Medicine, Comenius University in Bratislava, Bratislava, Slovakia.
Mária
M
Csöbönyeiová
Department of the Oromaxillofacial Surgery, Faculty of Medicine, Comenius University in Bratislava and University Hospital, Bratislava, Slovakia.
Ida
I
Kupcová
Department of Orthopaedics, Faculty of Medicine, Comenius University in Bratislava and Children's University Hospital, Bratislava, Slovakia.
Radoslav
R
Zamborský
Department of Plastic, Reconstructive and Aesthetic Surgery, Faculty of Medicine, Comenius University in Bratislava and University Hospital, Pažítkova 4, 826 06, Bratislava, Slovakia.
Jozef
J
Fedeleš
Department of Burn Surgery and Reconstructive Surgery, Faculty of Medicine, Comenius University in Bratislava and University Hospital, Bratislava, Slovakia.
Ján
J
Koller
D000818:Animals; D002921:Cicatrix / Q000628:therapy; D005402:Fistula / Q000628:therapy; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology / Q000637:transplantation; D016462:Mammaplasty / Q000379:methods; D019651:Plastic Surgery Procedures / Q000379:methods*; D012038:Regeneration; D044968:Regenerative Medicine / Q000379:methods*; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000166:cytology*; D023822:Tissue Engineering / Q000379:methods
Plastic surgery; Regenerative medicine; Stem cells; iPSCs