Study on the small intestine absorptive kinetics characters of tanshinol and protocatechualdehyde of Salvia miltiorrhiza extracts in rats in vivo.
In order to provide scientific basis for clinical selection of drugs, to compare and analyze the effective constitutes and the intestinal absorption in vivo in rats of the compound salvia tablets and compound salvia dropping pills (taken as the representatives). Determine the contents of tanshinol, protocatechuic aldehyde, salvianolic acid B and tanshinone II A, cryptotanshinone, ginseng saponin Rg1 and Rb1 in the compound salvia tablets and compound salvia dropping pills by High Performance Liquid Chromatography (HPLC). The intestinal absorption condition of the tanshinol, protocatechuic aldehyde, salvianolic acid B of the compound salvia tablets and compound salvia dropping pills in rats were detected by intestinal perfusion experiment. Only the intake of protocatechuic aldehyde in the compound salvia tablets was higher than in the compound dropping pills, the intake of the other 6 effective constitutes were all lower than in the compound dropping pills. The intestinal absorption of protocatechuic aldehyde was rather complete, while the intestinal absorption of tanshinol and salvianolic acid B were not significant. The duodenum was the main absorption region of these three components. The absorption of protocatechuic aldehyde was different in different regions of the intestines. Each intake of the effective constitutes in the tablets and dropping pills were significantly different, and the rat intestinal absorption of part of the components were different.
Vascular Surgery, Department of People's Hospital of Zhengzhou University, Zhengzhou, China.
Kai
K
Liang
Vascular Surgery, Department of People's Hospital of Zhengzhou University, Zhengzhou, China.
Shuiting
S
Zhai
Vascular Surgery, Department of People's Hospital of Zhengzhou University, Zhengzhou, China.
Zhidong
Z
Zhang
Vascular Surgery, Department of People's Hospital of Zhengzhou University, Zhengzhou, China.
Guoquan
G
Wang
Vascular Surgery, Department of People's Hospital of Zhengzhou University, Zhengzhou, China.
Xiaoyang
X
Fu
Vascular Intervention Department of People's Hospital of Zhengzhou University, Zhengzhou, China.
Tianxiao
T
Li
D000818:Animals; D001547:Benzaldehydes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002109:Caffeic Acids / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002396:Catechols / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004365:Drugs, Chinese Herbal; D004386:Duodenum / Q000378:metabolism; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000098:blood supply / Q000378:metabolism*; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow; D027561:Salvia miltiorrhiza / Q000737:chemistry*; D013607:Tablets
D001547:Benzaldehydes; D002109:Caffeic Acids; D002396:Catechols; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D013607:Tablets; C585969:tanshinol; C005581:protocatechualdehyde