Lanthanide (Gd(3+) and Yb(3+)) functionalized gold nanoparticles for in vivo imaging and therapy.
Nanoparticles are regularly used as contrast agents in bioimaging. Unlike other agents such as composite materials, nanoparticles can also be used for treating as well as imaging disease. Here we synthesized lanthanide functionalized gold nanoparticles that can be used for both imaging and therapy in vivo. That is a multifunctional nanoplatform was developed based on a simple and versatile method, by incorporating 10-nm gold nanoparticles and lanthanide ions (Gd(3+) and Yb(3+)), denoted as LnAu nanoparticles hereby. The LnAu nanoparticles were then surface-modified using a PEGylated amphiphilic polymer (C18MH-mPEG), and the resulting PEG modified LnAu nanoparticles (PEG-LnAu) display good monodispersion in water and good solubility in biological media. Due to the low toxicity in vitro and in vivo (as determined by a cell viability assay and histological and serum biochemistry analysis), the PEG-LnAu nanoparticles can be successfully applied to in vivo magnetic resonance imaging (MRI), in vivo computed tomography (CT) imaging and photothermal therapy (PTT) for tumor-bearing mice. Therefore, the present work developed an easy yet powerful strategy to combine lanthanide ions and gold nanoparticles to a unified nanoplatform for integrating bioimaging and therapy.
Research Center of Nano Science and Technology, and School of Material Science and Engineering, Shanghai University, Shanghai 200444, PR China.
Xiaoqian
X
Ge
Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai 200444, PR China.
Zheng-Mei
ZM
Song
Research Center of Nano Science and Technology, and School of Material Science and Engineering, Shanghai University, Shanghai 200444, PR China. Electronic address: lnsun@shu.edu.cn.
Lining
L
Sun
Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai 200444, PR China.
Yi-Fan
YF
Yang
Research Center of Nano Science and Technology, and School of Material Science and Engineering, Shanghai University, Shanghai 200444, PR China.
Liyi
L
Shi
Shanghai Synchrotron Radiation Facility, Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201204, PR China.
Rui
R
Si
Physics Department, and International Centre for Quantum and Molecular Structures, Shanghai University, Shanghai 200444, PR China.
Wei
W
Ren
Research Center of Nano Science and Technology, and School of Material Science and Engineering, Shanghai University, Shanghai 200444, PR China.
Xueer
X
Qiu
Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai 200444, PR China. Electronic address: hwang@shu.edu.cn.
Haifang
H
Wang
D000818:Animals; D045744:Cell Line, Tumor; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D003287:Contrast Media / Q000138:chemical synthesis; D006046:Gold / Q000737:chemistry / Q000627:therapeutic use; D006367:HeLa Cells; D006801:Humans; D028581:Lanthanoid Series Elements / Q000737:chemistry / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053768:Metal Nanoparticles / Q000737:chemistry / Q000627:therapeutic use* / Q000648:ultrastructure; D051379:Mice; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000628:therapy*; D010789:Phototherapy / Q000379:methods*; D011092:Polyethylene Glycols / Q000737:chemistry; D000068936:Theranostic Nanomedicine / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome
D020099:Coated Materials, Biocompatible; D003287:Contrast Media; D028581:Lanthanoid Series Elements; D011092:Polyethylene Glycols; D006046:Gold
Computed tomography (CT) imaging; Gold; Lanthanide; Magnetic resonance imaging (MRI); Photothermal therapy (PTT)