Experimental Models for Neurotrauma Research.
Physical trauma in the central nervous system (CNS) is usually the result of a number of forces in different directions and dimensions. A large number of experimental models have been developed to improve the possibilities to understand the outcome of CNS trauma. In this chapter, we will describe the need for a variety of experimental models for research on traumatic brain injury (TBI) and spinal cord injury (SCI). Models can serve different needs, such as: to test new treatments for injuries, to reveal thresholds for injuries, to provide a better understanding of injury mechanisms, or to test tools and methods for translation between experiments and clinical data. In this chapter, we will discuss on the validation of models and translation between experimental and clinical studies.
Vehicle Safety Division, Department of Applied Mechanics, Chalmers University of Technology, Göteborg, Sweden.
Johan
J
Davidsson
Experimental Traumatology, Department of Neuroscience, Karolinska Institutet, Retzius väg 8, 17177, Stockholm, Sweden. Marten.Risling@ki.se.
Mårten
M
Risling
D000818:Animals; D000070642:Brain Injuries, Traumatic / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D020833:Diffuse Axonal Injury / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D012106:Research; D013119:Spinal Cord Injuries / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D020196:Trauma, Nervous System / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology
Blast trauma; Diffuse axonal injury (DAI); Mechanisms; Traumatic brain injury (TBI); White matter