Immune complexes that contain HIV antigens activate peripheral blood T cells.
Uninfected donor T cells were treated in vitro by model immune complexes that contained either HIV or hepatitis C virus (HCV) antigens. Unlike HCV antigen-containing complexes, the immune complexes that contained HIV antigens have been shown to activate peripheral blood T cells of uninfected donors under in vitro conditions. Both the antiviral antibodies and HIV antigen were involved in the activation process. The unique properties of the immune complexes formed by HIV antigens and antiviral antibodies are believed to result from the virus-specific antibody properties and molecular conformation of the antigen-antibody complex.
Institute of Ecology and Genetics of Microorganisms, Ural Division, Russian Academy of Sciences, Perm, Russia. bioqueen@mail.ru.|Perm State National Research University, Perm, Russia. bioqueen@mail.ru.
L B
LB
Korolevskaya
Institute of Ecology and Genetics of Microorganisms, Ural Division, Russian Academy of Sciences, Perm, Russia.|Perm State National Research University, Perm, Russia.
K V
KV
Shmagel
Institute of Ecology and Genetics of Microorganisms, Ural Division, Russian Academy of Sciences, Perm, Russia.|Perm State National Research University, Perm, Russia.
E V
EV
Saidakova
Perm State National Research University, Perm, Russia.|Perm AIDS Center, Perm, Russia.
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NG
Shmagel
Perm State National Research University, Perm, Russia.|Institute of Immunology and Physiology, Ural Dividion, Russian Academy of Sciences, Yekaterinburg, Russia.
V A
VA
Chereshnev
D000914:Antibodies, Viral / Q000276:immunology*; D000936:Antigen-Antibody Complex / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology*; D005260:Female; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*
D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D000956:Antigens, Viral