Phosphodiesterase type 5 inhibitor administered immediately after radical prostatectomy temporarily increases the need for incontinence pads, but improves final continence status.
To evaluate the effects of phosphodiesterase type 5 inhibitor (PDE5i) on urinary continence recovery after bilateral nerve-sparing radical prostatectomy (BNSRP).



Between 2002 and 2012, 137 of 154 consecutive patients who underwent BNSRP in our institution retrospectively divided into 3 groups that included patients taking PDE5i immediately after surgery (immediate PDE5i group, n=41), patients starting PDE5i at an outpatient clinic after discharge (PDE5i group, n=56), and patients taking no medication (non-PDE5i group, n=40). Using self-administered questionnaires, the proportion of patients who did not require incontinence pads (pad-free patients) was calculated preoperatively and at 1, 3, 6, 12, 18, and 24 months after BNSRP. Severity of incontinence was determined based on the pad numbers and then compared among the 3 groups.



Proportions of pad-free patients and severity of incontinence initially deteriorated in all of the groups to the lowest values soon after undergoing BNSRP, with gradual improvement noted thereafter. The deterioration was most prominent in the immediate PDE5i group. As compared to the non-PDE5i group, both the PDE5i and immediate PDE5i groups exhibited a better final continence status.



PDE5i improves final continence status. However, administration of PDE5i immediately after surgery causes a distinct temporary deterioration in urinary incontinence.
Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Yasuhiro
Y
Kaiho
Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Shinichi
S
Yamashita
Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Akihiro
A
Ito
Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Yoshihide
Y
Kawasaki
Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Hideaki
H
Izumi
Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Naoki
N
Kawamorita
Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Hisanobu
H
Adachi
Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Koji
K
Mitsuzuka
Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Yoichi
Y
Arai
D000368:Aged; D004334:Drug Administration Schedule; D004341:Drug Evaluation / Q000379:methods; D005500:Follow-Up Studies; D006801:Humans; D016496:Incontinence Pads / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D058986:Phosphodiesterase 5 Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D011182:Postoperative Care / Q000379:methods; D011468:Prostatectomy / Q000009:adverse effects* / Q000379:methods; D020127:Recovery of Function / Q000187:drug effects; D012189:Retrospective Studies; D012720:Severity of Illness Index; D014549:Urinary Incontinence / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D014554:Urination / Q000187:drug effects
D058986:Phosphodiesterase 5 Inhibitors
Incontinence pads; Phosphodiesterase inhibitors; Prostatectomy; Recovery of function; Urinary incontinence