[Large Hibernoma of the Proximal Upper Arm and the Axilla - Literature Review and Case Description of a Very Rare Benign Soft Tissue Tumor].
Hibernomas are very rare benign soft tissue tumors arising from brown fat. Malignant transformation or metastases are unknown. Males seems to be affected more often. Most patients are aged 20 to 40, but patients with intraosseous hibernomas are older. In children, hibernomas are extremely rare. The tumors grow slowly and have usually been present for a few years on presentation. Hibernomas are typically located on the thigh, neck, axilla or in the peri- und interscapular region. Diagnostic work-up in symptomatic hibernomas usually includes conventional X-ray and magnetic resonance tomography (MRI) with contrast medium. Asymptomatic hibernomas are often found accidentally in the diagnostic work-up of other diseases. Important differential diagnoses are lipomas, well differentiated liposarcomas, rhabdomyomas, granular cell tumors and sebeceous adenomas. Incisional biopsy should be performed to allow definitive histological diagnosis before definitive therapy. According to the literature, histologically preserved hibernomas can be removed with curative intention and marginal resection. After complete tumor removal, local recurrence has not been described. The following article describes the case of a large hibernoma of the proximal arm, involving the axilla, and describes the epidemiology, clinical behavior, diagnostic work-up, therapy and prognosis of this very rare benign fatty soft tissue tumor, on the basis of a review of current literature.
Klinik für Orthopädie, Universitätsklinikum Ulm.
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B
Ulmar
Klinik für Orthopädie, Universitätsklinikum Ulm.
A
A
Trubrich
Klinik für Orthopädie, Universitätsklinikum Ulm.
T
T
Kappe
Klinik für Orthopädie, Universitätsklinikum Ulm.
T
T
Kocak
Abteilung Neurochirurgie, Bundeswehrkrankenhaus Ulm.
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C
Schulz
Klinik für Orthopädie, Universitätsklinikum Ulm.
H
H
Reichel
Klinik für Orthopädie, Universitätsklinikum Ulm.
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F
Leucht
D001132:Arm / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D001365:Axilla / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008067:Lipoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D035583:Rare Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome