Plasma inflammatory biomarkers response to aerobic versus resisted exercise training for chronic obstructive pulmonary disease patients.
BACKGROUND
Chronic obstructive pulmonary disease (COPD) is a main risk for morbidity, associated with alterations in systemic inflammation. Recent studies proved that morbidity and mortality of COPD is related to systemic inflammation as it contributes to the pathogenesis of atherosclerosis and cardiovascular disease. However, increase of inflammatory cytokines adversely affects quality of life, alteration in ventilatory and skeletal muscles functions. Moreover, exercise training has many beneficial effects in correction of the adverse effects of COPD.


OBJECTIVE
This study aimed to compare the response of inflammatory cytokines of COPD to aerobic versus resisted exercises.


METHODS
One hundred COPD diseased patients participated in this study and were randomly included in two groups; the first group received aerobic exercise, whereas the second group received resisted exercise training for 12 weeks.


RESULTS
The mean values of TNF-α, Il-2, IL-4, IL-6 and CRP were significantly decreased in both groups. Also; there was a significant difference between both groups at the end of the study with more reduction in patients who received aerobic exercise training.


CONCLUSIONS
Aerobic exercise is more appropriate than resisted exercise training in modulating inflammatory cytokines level in patients with chronic obstructive pulmonary disease.
Department of Physical Therapy, Faculty of Applied Medical Sciences, King Abdulaziz University.
Shehab M
SM
Abd El-Kader
Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University.
Osama H
OH
Al-Jiffri
Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University.
Fadwa M
FM
Al-Shreef
D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis; D016207:Cytokines / Q000097:blood*; D015444:Exercise / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000534:rehabilitation*; D055070:Resistance Training; D012129:Respiratory Function Tests; D012720:Severity of Illness Index; D016896:Treatment Outcome
D016207:Cytokines; D018836:Inflammation Mediators; D002097:C-Reactive Protein
Aerobic exercise; chronic obstructive pulmonary disease; inflammatory cytokines; resisted exercises