Combined treatment of prednisone and aspirin, starting before ovulation induction, may improve reproductive outcomes in ANA-positive patients.
Antinuclear antibody (ANA) could cause reproductive failure. But treatment for women with antinuclear antibody was controversial.



One hundred and thirty-three ANA+ women with one-time in vitro fertilization (IVF) implantation failure were divided into two groups randomly. The study group comprised 60 sero-positive for antinuclear antibody. These patients were treated with prednisone (10 mg/day) and aspirin (100 mg/day) starting 3 months before induction of ovulation in 60 IVF cycles. Seventy-three patients were included in untreated group.



Fertilization rate, pregnancy rate, and implantation rate were significantly higher in treatment group, while abortion rate was markedly higher in non-treatment group by randomized controlled trial. Same conclusions were also proved between cycles of 60 ANA+ women with therapy and their former cycles without any treatment.



Combined treatment of prednisone for immunosuppression and aspirin as an antithrombotic agent, starting 3 months before ovulation induction, may improve reproductive outcomes in ANA+ patients.
Key Laboratory of Reproductive Medicine of Guangdong Province, Reproductive Medicine Center for The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Jiao
J
Fan
Key Laboratory of Reproductive Medicine of Guangdong Province, Reproductive Medicine Center for The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. zypdoctor66@163.com.
Yiping
Y
Zhong
Key Laboratory of Reproductive Medicine of Guangdong Province, Reproductive Medicine Center for The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Cuina
C
Chen
D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood; D001241:Aspirin / Q000627:therapeutic use*; D065187:Controlled Before-After Studies; D004359:Drug Therapy, Combination; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D005307:Fertilization in Vitro; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007247:Infertility, Female / Q000188:drug therapy* / Q000276:immunology; D010062:Ovulation Induction; D011241:Prednisone / Q000627:therapeutic use*; D011247:Pregnancy; D018873:Pregnancy Rate; D016896:Treatment Outcome
D000974:Antibodies, Antinuclear; D005343:Fibrinolytic Agents; D007166:Immunosuppressive Agents; D001241:Aspirin; D011241:Prednisone
antinuclear antibody; aspirin; prednisone