Continuous flow room temperature reductive aqueous homo-coupling of aryl halides using supported Pd catalysts.
A convenient and environmentally friendly protocol for the preparation of biaryls at room temperature under continuous flow conditions is reported. A simple reductive homo-coupling Ullmann-type reaction was performed in an H-Cube mini using commercially available supported Pd catalysts under mild reaction conditions, with quantitative conversion to target products. Commercial Pd catalysts were found to be highly stable under the investigated reaction conditions, with a minimum Pd leaching into solution after several reaction runs (ca. 20 h on stream).
Organic Chemistry Department, Shahid Beheshti University, Tehran 1983963113, Iran.|Departamento de Quimica Organica, Facultad de Ciencias, Universidad de Cordoba, Campus de Rabanales, Edificio Mariec Curie (C-3), Ctra Nnal Madrid-Cadiz, Km 396, E14014,Cordoba, Spain.
Afsaneh
A
Feiz
Organic Chemistry Department, Shahid Beheshti University, Tehran 1983963113, Iran.
Ayoob
A
Bazgir
Departamento de Quimica Organica, Facultad de Ciencias, Universidad de Cordoba, Campus de Rabanales, Edificio Mariec Curie (C-3), Ctra Nnal Madrid-Cadiz, Km 396, E14014,Cordoba, Spain.
Alina M
AM
Balu
Departamento de Quimica Organica, Facultad de Ciencias, Universidad de Cordoba, Campus de Rabanales, Edificio Mariec Curie (C-3), Ctra Nnal Madrid-Cadiz, Km 396, E14014,Cordoba, Spain.
Rafael
R
Luque