The Irony of Tumor-Induced Inflammation.
Increased dietary iron intake and elevated systemic iron levels are associated with increased cancer risk. In this issue, Xue et al. (2016) have identified an unexpected link between intracellular iron accumulation and pro-inflammatory signaling that provides, at least in part, a molecular explanation for the tumor-promoting effects of iron.
Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Paul-Ehrlich-Str. 42-44, 60596 Frankfurt am Main, Germany. Electronic address: greten@gsh.uni-frankfurt.de.
Florian R
FR
Greten
D004032:Diet; D006801:Humans; D007249:Inflammation; D007501:Iron; D019266:Iron, Dietary; D009369:Neoplasms
D019266:Iron, Dietary; D007501:Iron