Serum LDL (Low Density Lipoprotein) As a Risk Factor for Ischemic Stroke.
Atherosclerosis is the main risk factor of ischaemic stroke. Dyslipidaemia is the main cause of atherosclerosis. High levels of LDL, also called "bad" cholesterol, seem to provoke stroke. This case control study was conducted in Mymensingh Medical College Hospital during the period of January 2012 to December 2012. The study was carried out to measure the level of serum LDL (Low Density Lipoprotein) of ischaemic stroke patients admitted in Medicine wards of Mymensingh Medical College Hospital and the result of this study was compared with the level of LDL cholesterol in age matched controls. Sample size was 384 which had been selected by inclusion and exclusion criteria. Out of 384 samples 192 were cases and 192 were controls. Mean age ±SD was 57.0±10.85 years in cases and 57.43±10.64 years in controls. Elderly people are the most vulnerable group for developing stroke. LDL cholesterol level was more than 130mg/dl was found 88.54% among cases and 33.85% among controls, the difference was statistically significant (p<0.05). Mean LDL level ±SD were 145±13.59mg/dl in cases and 125.01±10.73mg/dl in controls. Odds ratio of LDL cholesterol were 15.0979 and 95% confidence limits were 8.8396 to 25.7869 among cases and controls. This study explored study population with higher LDL cholesterol was over fifteen times more likely to developed ischaemic stroke. Early detection of high LDL cholesterol in the way to prevent ischaemic stroke and thereby reduced the morbidity and mortality of ischaemic stroke.
Dr Nabarun Biswas, Medical Officer, Department of Pharmacology, Mymensingh Medical College, Mymensingh, Bangladesh.
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D000368:Aged; D002545:Brain Ischemia / Q000453:epidemiology; D016022:Case-Control Studies; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications; D008875:Middle Aged; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL