The role of microRNAs in intrahepatic cholangiocarcinoma.
Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic malignancy with poor prognosis. Despite improvements in its diagnosis and therapy, the prognosis for ICC patients remains poor. An improved understanding of ICC pathogenesis and consequential identification of novel therapeutic targets would improve the prognosis of ICC patients. MicroRNAs (miRNAs) are a class of highly conserved, endogenous, small non-coding RNA molecules of 18-23 nucleotides in length, which regulate gene expression through complementary base-pairing with target messenger RNAs and subsequent gene silencing. Several studies have shown deregulated expression of miRNAs in ICC cell lines and tissues, in which these miRNAs play important roles in ICC apoptosis, cell proliferation, invasion, migration and metastasis. In this review, we illustrate the potential role of miRNA in the pathogenesis of ICC and explore the possibilities of using miRNAs as prognostic and diagnostic markers, as well as therapeutic targets in ICC.
Department of Orthopedics Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zheng
Z
Li
Department of Orthopedics Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Jianxiong
J
Shen
Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China.
Matthew T V
MT
Chan
Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China.|State Key Laboratory of Digestive Daase, LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.
William Ka Kei
WK
Wu
D001650:Bile Duct Neoplasms / Q000235:genetics* / Q000473:pathology; D018281:Cholangiocarcinoma / Q000235:genetics* / Q000473:pathology; D015870:Gene Expression / Q000235:genetics; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology; D035683:MicroRNAs / Q000235:genetics*; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics
D035683:MicroRNAs; D012333:RNA, Messenger
Intrahepatic cholangiocarcinoma; apoptosis; metastasis; microRNAs; prognosis; proliferation