Recurrence of Preterm Delivery in Women with a Family History of Preterm Delivery.
ObjectiveThis study aims to evaluate the role of a family history of preterm delivery on the risk of preterm delivery in the next generation.Study DesignA retrospective population-based study was conducted. Perinatal information was gathered from 2,303 familial triads, composed of mothers (F1), daughters (F2), and children (F3). All births occurred in the same regional medical center between the years 1991 and 2013. Statistical analysis using logistic regression was performed to define the risk of F2delivering a preterm baby (F3) if she was born preterm herself, and then to define the risk of F2delivering preterm if her mother (F1) gave birth preterm during any of her birthing events.ResultsThe risk for preterm delivery of the F2parturient was 34% greater if their mother (F1) at any of her births had delivered preterm, controlling for parity, maternal age at delivery, and preeclampsia (adjusted odds ratio: 1.34, 95% confidence interval: -1.01 to 1.77;p= 0.042).ConclusionThe family history of preterm delivery is an independent risk factor for preterm delivery. The family history includes the mother as well as one of the mother's sisters (F2generation) being born preterm.
The Joyce and Irving Goldman Medical School, Faculty of Health Sciences, Soroka University Medical Center, Ben Gurion University of the Negev, Be'er-Sheva, Israel.
Yehonatan
Y
Sherf
Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben Gurion University of the Negev, Be'er-Sheva, Israel.
Eyal
E
Sheiner
Department of Public Health, Faculty of Health Sciences, Ben Gurion University of the Negev, Be'er-Sheva, Israel.
Ilana Shoham
IS
Vardi
Department of Public Health, Faculty of Health Sciences, Ben Gurion University of the Negev, Be'er-Sheva, Israel.
Ruslan
R
Sergienko
The Medical School for International Health in Affiliation with Columbia University, Faculty of Health Sciences, Ben Gurion University of the Negev, Be'er-Sheva, Israel.
Jamie
J
Klein
Department of Public Health, Faculty of Health Sciences, Ben Gurion University of the Negev, Be'er-Sheva, Israel.
Natalya
N
Bilenko
D000328:Adult; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008487:Medical History Taking; D016017:Odds Ratio; D011247:Pregnancy; D047928:Premature Birth / Q000453:epidemiology* / Q000235:genetics*; D012008:Recurrence; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D055815:Young Adult