Frequent rhabdomyolysis in anti-NMDA receptor encephalitis.
The aim of this study was to analyze the clinical presentation and provocation factors of rhabdomyolysis in anti-NMDAR encephalitis. Among the 16 patients with anti-NMDAR encephalitis in our institutional cohort, nine patients had elevated CK enzyme levels and clinical evidence of rhabdomyolysis. Rhabdomyolysis was more frequent after immunotherapy. The use of dopamine receptor blocker (DRB) increased the risk of rhabdomyolysis. None of the patients without rhabdomyolysis received DRBs. Rhabdomyolysis is a frequent complication in anti-NMDAR encephalitis and more common after immunotherapy and the use of DRBs increases the risk. Therefore, DRBs should be administered carefully in patients with anti-NMDAR encephalitis.
Department of Neurology, Biomedical Research Institute, Seoul National University Hospital, College of Medicine, Seoul National University, Seoul, South Korea.
Jung-Ah
JA
Lim
Department of Neurology, Biomedical Research Institute, Seoul National University Hospital, College of Medicine, Seoul National University, Seoul, South Korea.
Soon-Tae
ST
Lee
Department of Neurology, Biomedical Research Institute, Seoul National University Hospital, College of Medicine, Seoul National University, Seoul, South Korea.
Tae-Joon
TJ
Kim
Department of Neurology, Biomedical Research Institute, Seoul National University Hospital, College of Medicine, Seoul National University, Seoul, South Korea.
Jangsup
J
Moon
Department of Neurology, Biomedical Research Institute, Seoul National University Hospital, College of Medicine, Seoul National University, Seoul, South Korea; Department of Neurology, Soonchunhyang University School of Medicine, Seoul, South Korea.
Jun-Sang
JS
Sunwoo
Department of Neurology, Biomedical Research Institute, Seoul National University Hospital, College of Medicine, Seoul National University, Seoul, South Korea; Department of Neurology, Kyung Hee University Hospital at Gangdong, Seoul, South Korea.
Jung-Ick
JI
Byun
Department of Neurology, Biomedical Research Institute, Seoul National University Hospital, College of Medicine, Seoul National University, Seoul, South Korea.
Keun-Hwa
KH
Jung
Department of Neurology, Biomedical Research Institute, Seoul National University Hospital, College of Medicine, Seoul National University, Seoul, South Korea.
Ki-Young
KY
Jung
Department of Neurology, Biomedical Research Institute, Seoul National University Hospital, College of Medicine, Seoul National University, Seoul, South Korea. Electronic address: stemcell.snu@gmail.com.
Kon
K
Chu
Department of Neurology, Biomedical Research Institute, Seoul National University Hospital, College of Medicine, Seoul National University, Seoul, South Korea. Electronic address: sangkun2923@gmail.com.
Sang Kun
SK
Lee
D000293:Adolescent; D000328:Adult; D060426:Anti-N-Methyl-D-Aspartate Receptor Encephalitis / Q000150:complications* / Q000453:epidemiology* / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003402:Creatine Kinase; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000009:adverse effects; D007223:Infant; D008297:Male; D016194:Receptors, N-Methyl-D-Aspartate; D012206:Rhabdomyolysis / Q000453:epidemiology* / Q000209:etiology*; D055815:Young Adult
D016194:Receptors, N-Methyl-D-Aspartate; D003402:Creatine Kinase
Autoimmune encephalitis; Encephalitis; NMDA; Rhabdomyolysis