A New Case of a Complex Small Supernumerary Marker Chromosome: A Der(9)t(7;9)(p22;q22) due to a Maternal Balanced Rearrangement.
Complex small supernumerary marker chromosomes (sSMCs) constitute one of the smallest subsets within the patients with an sSMC. Complex sSMCs consist of chromosomal material derived from more than one chromosome, for example, the derivative der(22)t(11;22)(q23;q11.2) in Emanuel syndrome. Here, a yet unreported case of a complex sSMC formed due to a t(7;9)(p22;q22)mat is presented.
Jena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Jena, Germany; Research Center of Maternal and Child Health Protection, Yerevan, Armenia.
Marine
M
Manvelyan
Research Center of Maternal and Child Health Protection, Yerevan, Armenia.
Izabella
I
Simonyan
Department of Genetics and Cytology, Yerevan State University, Yerevan, Armenia.
Galina
G
Hovhannisyan
Department of Genetics and Cytology, Yerevan State University, Yerevan, Armenia.
Rouben
R
Aroutiounian
Jena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Jena, Germany.
Ahmed B
AB
Hamid
Jena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Jena, Germany.
Thomas
T
Liehr
complex small supernumerary marker chromosomes (sSMCs); genotype-phenotype correlation; partial trisomy 7; partial trisomy 9