Investigation of titania nanoparticles on behaviour and mechanosensory organ of Drosophila melanogaster.
Titania nanoparticles are used in food, cosmetic, medicine, paint and many more domestic items. Its extensive use has raised the threat to the physiological system and thus the functioning of the body. In the current study, the toxicity of TiO2is checked by adding it in food and using Drosophila melanogaster as a model organism. Various concentrations of TiO2(50, 100, 200, 250mg·L-1) toxicity was assessed via oral route exposure. Survivability, life-cycle, mechanosensory behaviour and structure of various mechanosensory organs were monitored as a read out of nanoparticle toxicity. TiO2NPs generate reactive oxygen species which can modify multiple signalling pathways and thus can alter the development and behavioural pattern of the fly.
Department of Life Science, National Institute of Technology, Rourkela, Odisha 769008, India.
Debabrat
D
Sabat
Department of Life Science, National Institute of Technology, Rourkela, Odisha 769008, India.
Abhinandan
A
Patnaik
Department of Chemistry, National Institute of Technology, Rourkela, Odisha 769008, India.
Basanti
B
Ekka
Department of Chemistry, National Institute of Technology, Rourkela, Odisha 769008, India.
Priyabrat
P
Dash
Department of Life Science, National Institute of Technology, Rourkela, Odisha 769008, India. Electronic address: mishramo@nitrkl.ac.in.
Monalisa
M
Mishra
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001672:Biocompatible Materials / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D020552:Comet Assay; D004305:Dose-Response Relationship, Drug; D004331:Drosophila melanogaster / Q000187:drug effects*; D005106:Exploratory Behavior / Q000187:drug effects; D007814:Larva / Q000187:drug effects; D008854:Microscopy, Electron; D053758:Nanoparticles / Q000633:toxicity* / Q000648:ultrastructure; D011679:Pupa / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism; D012679:Sense Organs / Q000187:drug effects* / Q000648:ultrastructure; D014025:Titanium / Q000494:pharmacology*; D014961:X-Ray Diffraction
D001672:Biocompatible Materials; D017382:Reactive Oxygen Species; C009495:titanium dioxide; D014025:Titanium
Behaviour; Drosophila melanogaster; Titania nanoparticles; Toxicity