To Swap or Not To Swap.
Domain swapping is a form of protein oligomerization in which identical structural units are exchanged among protomers within an oligomer. In this issue of Structure, Assar et al. (2016) report domain-swapped dimers of hCREBPII, pinpointing a single hydrogen bond and protein concentration as two critical regulators of the monomer/dimer balance.
Department of Chemistry & Biochemistry, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address: gghosh@ucsd.edu.
Gourisankar
G
Ghosh
Department of Chemistry & Biochemistry, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Tapan
T
Biswas
D019281:Dimerization; D006860:Hydrogen Bonding; D017434:Protein Structure, Tertiary