Durability of Artificial Urinary Sphincter With Prior Radiation Therapy.
The aim of this study was to investigate the effect of prior radiation therapy on artificial urinary sphincter.



Group 1 was comprised of 63 men who underwent prior radical prostatectomy, and Group 2 was comprised of 31 men who received prior radiation therapy with or without prior radical prostatectomy. Social incontinence was defined as requiring to use > 1 pad per day and/or catheter-dependent at the time of last follow-up.



The median age at artificial urinary sphincter placement was 71 years (interquartile range, 55-74 years). The median and mean follow-up was 62 months (interquartile range, 37-106 months) and 75 months (range, 2-205 months), respectively. At the time of last follow-up, 67% (63 of 94) of the men in the entire cohort (73% [46 of 63] and 55% [17 of 31] in Group 1 and Group 2, respectively [P = .078]) were socially continent. Sphincter revision, erosion, infection, and removal rates were 20%, 20%, 7%, and 10%, respectively, in Group 1, and 26%, 13%, 7%, and 23%, respectively, in Group 2. The differences in these rates were not statistically significant between the 2 groups.



We found no significant difference in functionality (incontinence rates) and outcomes (rates of sphincter revision, erosion, infection, and removal) between the 2 groups. The message for patients is that prior radiation does not significantly alter the outcomes of artificial urinary sphincter.
Department of Radiation Oncology, Baylor Scott and White Health, Temple, TX. Electronic address: sameer.jhavar@gmail.com.
Sameer
S
Jhavar
Department of Radiation Oncology, Baylor Scott and White Health, Temple, TX.
Gregory
G
Swanson
Department of Radiation Oncology, Baylor Scott and White Health, Temple, TX.
Niloyjyoti
N
Deb
Texas A&M Health Sciences Center, Baylor Scott and White Health, Temple, TX.
Lake
L
Littlejohn
Department of Biostatistics, Baylor Scott and White Health, Temple, TX.
Jessica
J
Pruszynski
Department of Urology, Baylor Scott and White Health, Temple, TX.
Graham
G
Machen
Department of Urology, Baylor Scott and White Health, Temple, TX.
Preston
P
Milburn
Department of Urology, Baylor Scott and White Health, Temple, TX.
Erin
E
Bird
D000368:Aged; D006801:Humans; D008297:Male; D008875:Middle Aged; D011468:Prostatectomy / Q000009:adverse effects; D011471:Prostatic Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D019919:Prosthesis Implantation / Q000379:methods*; D011878:Radiotherapy / Q000009:adverse effects*; D012086:Reoperation; D016896:Treatment Outcome; D014549:Urinary Incontinence / Q000209:etiology / Q000601:surgery*; D016741:Urinary Sphincter, Artificial / Q000009:adverse effects / Q000382:microbiology
Artificial urinary sphincter; Prostate cancer; Prostatectomy; Radiotherapy; Urinary incontinence