In Vitro Growth Inhibitory Activities of Natural Products from Irciniid Sponges against Cancer Cells: A Comparative Study.
Marine sponges of the Irciniidae family contain both bioactive furanosesterterpene tetronic acids (FTAs) and prenylated hydroquinones (PHQs). Both classes of compounds are known for their anti-inflammatory, antioxidant, and antimicrobial properties and known to display growth inhibitory effects against various human tumor cell lines. However, the different experimental conditions of the reported in vitro bioassays, carried out on different cancer cell lines within separate studies, prevent realistic actual discrimination between the two classes of compounds from being carried out in terms of growth inhibitory effects. In the present work, a chemical investigation of irciniid sponges from Tunisian coasts led to the purification of three known FTAs and three known PHQs. The in vitro growth inhibitory properties of the six purified compounds have been evaluated in the same experiment in a panel of five human and one murine cancer cell lines displaying various levels of sensitivity to proapoptotic stimuli. Surprisingly, FTAs and PHQs elicited distinct profiles of growth inhibitory-responses, differing by one to two orders of magnitude in favor of the PHQs in all cell lines. The obtained comparative results are discussed in the light of a better selection of drug candidates from natural sources.
Institut National des Sciences et Technologies de la Mer (INSTM), Salammbô, 2025 Tunis, Tunisia.
Yosr
Y
BenRedjem Romdhane
Institut National des Sciences et Technologies de la Mer (INSTM), Salammbô, 2025 Tunis, Tunisia.
Monia
M
Elbour
Consiglio Nazionale delle Ricerche (CNR), Istituto di Chimica Biomolecolare (ICB), 80078 Pozzuoli, Italy.
Marianna
M
Carbone
Consiglio Nazionale delle Ricerche (CNR), Istituto di Chimica Biomolecolare (ICB), 80078 Pozzuoli, Italy.
Maria Letizia
ML
Ciavatta
Consiglio Nazionale delle Ricerche (CNR), Istituto di Chimica Biomolecolare (ICB), 80078 Pozzuoli, Italy.
Margherita
M
Gavagnin
Laboratoire de Cancérologie et de Toxicologie Expérimentale, Faculté de Pharmacie, Université Libre de Bruxelles (ULB), 1050 Brussels, Belgium.
Véronique
V
Mathieu
Service de Neurochirurgie, Hôpital Erasme, ULB, 1070 Brussels, Belgium.
Florence
F
Lefranc
Institut National des Sciences et Technologies de la Mer (INSTM), Salammbô, 2025 Tunis, Tunisia.
Leila
L
Ktari
Institut National des Sciences et Technologies de la Mer (INSTM), Salammbô, 2025 Tunis, Tunisia.
Karim
K
Ben Mustapha
Laboratoire des Microorganismes et Biomolécules actives, Faculté des Sciences de Tunis, 2092 Tunis, Tunisia.
Abdellatif
A
Boudabous
Laboratoire de Cancérologie et de Toxicologie Expérimentale, Faculté de Pharmacie, Université Libre de Bruxelles (ULB), 1050 Brussels, Belgium.
Robert
R
Kiss
Consiglio Nazionale delle Ricerche (CNR), Istituto di Chimica Biomolecolare (ICB), 80078 Pozzuoli, Italy.
Ernesto
0000-0001-7379-1788
E
Mollo
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D059001:Aquatic Organisms / Q000737:chemistry*; D001681:Biological Assay; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006801:Humans; D061986:MCF-7 Cells; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D011161:Porifera / Q000737:chemistry*
D000970:Antineoplastic Agents