Cisplatin and Cetuximab Treatment for Metastatic Cutaneous Squamous Cell Carcinoma: A Systematic Review.
BACKGROUND
Cutaneous squamous cell carcinoma (cSCC) is the second most common form of skin cancer and metastasizes in 2% to 5% of cases.


OBJECTIVE
Systematic evaluation of published cases of metastatic cSCC (mSCC) treated with cisplatin or cetuximab from 1989 to 2014.


METHODS
A literature search was performed to identify cases of mSCC treated with cisplatin or cetuximab. Patient demographics, tumor characteristics, response rates, and disease-free survivals were extracted.


RESULTS
A total of 60 cases of mSCC treated with cisplatin and 9 cases treated with cetuximab reported in the literature from 1989 to 2014 were included in the analysis. Patients treated with cetuximab obtained a complete response of 67%, an overall response of 78%, and a median disease-free survival of 25 (range 3-48) months. Patients treated with cisplatin obtained a complete response of 22%, an overall response of 45%, and a median disease-free survival of 14.6 (range 3-112) months.


CONCLUSIONS
Head-to-head prospective clinical studies between cetuximab and cisplatin are needed to determine which is more efficacious. In addition, prospective tumor registries and randomized controlled trials should be developed in order to establish the ideal systemic regimen in cSCC.
*School of Medicine, Keck School of Medicine of USC, Los Angeles, California; †Caruso Department of Otolaryngology, Head and Neck Surgery, Keck School of Medicine of USC, Los Angeles, California; ‡Medical Oncology, Department of Internal Medicine, Keck School of Medicine of USC, Los Angeles, California; §USC Department of Dermatology, Keck School of Medicine of USC, Los Angeles, California.
Cameron
C
Trodello
Jon-Paul
JP
Pepper
Michael
M
Wong
Ashley
A
Wysong
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000556:secondary* / Q000628:therapy; D000068818:Cetuximab / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use*; D018572:Disease-Free Survival; D006801:Humans; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000628:therapy
D000970:Antineoplastic Agents; D000068818:Cetuximab; D002945:Cisplatin