Adenosine A2B Receptor: From Cell Biology to Human Diseases.
Extracellular adenosine is a ubiquitous signaling molecule that modulates a wide array of biological processes. Recently, significant advances have been made in our understanding of A2B adenosine receptor (A2BAR). In this review, we first summarize some of the general characteristics of A2BAR, and then we describe the multiple binding partners of the receptor, such as newly identified α-actinin-1 and p105, and discuss how these associated proteins could modulate A2BAR's functions, including certain seemingly paradoxical functions of the receptor. Growing evidence indicates a critical role of A2BAR in cancer, renal disease, and diabetes, in addition to its importance in the regulation of vascular diseases, and lung disease. Here, we also discuss the role of A2BAR in cancer, renal disease, and diabetes and the potential of the receptor as a target for treating these three diseases.
Department of Biology, South University of Science and Technology of ChinaShenzhen, China; Shenzhen Key Laboratory of Cell Microenvironment, South University of Science and Technology of ChinaShenzhen, China.
Ying
Y
Sun
Division of Life Science, Hong Kong University of Science and TechnologyHong Kong, China; Division of Biomedical Engineering, Hong Kong University of Science and TechnologyHong Kong, China; State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and TechnologyHong Kong, China.
Pingbo
P
Huang
A2B adenosine receptor; binding proteins; cancer; diabetes; renal disease