Increase in colonic diverticular hemorrhage and confounding factors.
OBJECTIVE
To classify changes over time in causes of lower gastrointestinal bleeding (LGIB) and to identify factors associated with changes in the incidence and characteristics of diverticular hemorrhage (DH).


METHODS
A total of 1803 patients underwent colonoscopy for overt LGIB at our hospital from 1995 to 2013. Patients were divided into an early group (EG, 1995-2006, n = 828) and a late group (LG, 2007-2013, n = 975), and specific diseases were compared between groups. In addition, antithrombotic drug (ATD) use and nonsteroidal anti-inflammatory drug (NSAID) use were compared between patients with and without DH.


RESULTS
Older patients (≥ 70 years old) and those with colonic DH were more frequent in LG than in EG (P < 0.01). Patients using ATDs as well as NSAIDs, male sex, obesity (body mass index ≥ 25 kg/m(2)), smoking, alcohol drinking, and arteriosclerotic diseases were more frequent in patients with DH than in those without.


CONCLUSIONS
Incidence of colonic DH seems to increase with aging of the population, and factors involved include use of ATDs and NSAIDs, male sex, obesity, smoking, alcohol drinking, and arteriosclerotic disease. These factors are of value in handling DH patients.
Ken Kinjo, Toshiyuki Matsui, Takashi Hisabe, Hiroshi Ishihara, Shinichiro Maki, Kenta Chuman, Akihiro Koga, Kensei Ohtsu, Noritaka Takatsu, Fumihito Hirai, Kenshi Yao, Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka 818-8502, Japan.
Ken
K
Kinjo
Ken Kinjo, Toshiyuki Matsui, Takashi Hisabe, Hiroshi Ishihara, Shinichiro Maki, Kenta Chuman, Akihiro Koga, Kensei Ohtsu, Noritaka Takatsu, Fumihito Hirai, Kenshi Yao, Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka 818-8502, Japan.
Toshiyuki
T
Matsui
Ken Kinjo, Toshiyuki Matsui, Takashi Hisabe, Hiroshi Ishihara, Shinichiro Maki, Kenta Chuman, Akihiro Koga, Kensei Ohtsu, Noritaka Takatsu, Fumihito Hirai, Kenshi Yao, Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka 818-8502, Japan.
Takashi
T
Hisabe
Ken Kinjo, Toshiyuki Matsui, Takashi Hisabe, Hiroshi Ishihara, Shinichiro Maki, Kenta Chuman, Akihiro Koga, Kensei Ohtsu, Noritaka Takatsu, Fumihito Hirai, Kenshi Yao, Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka 818-8502, Japan.
Hiroshi
H
Ishihara
Ken Kinjo, Toshiyuki Matsui, Takashi Hisabe, Hiroshi Ishihara, Shinichiro Maki, Kenta Chuman, Akihiro Koga, Kensei Ohtsu, Noritaka Takatsu, Fumihito Hirai, Kenshi Yao, Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka 818-8502, Japan.
Shinichiro
S
Maki
Ken Kinjo, Toshiyuki Matsui, Takashi Hisabe, Hiroshi Ishihara, Shinichiro Maki, Kenta Chuman, Akihiro Koga, Kensei Ohtsu, Noritaka Takatsu, Fumihito Hirai, Kenshi Yao, Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka 818-8502, Japan.
Kenta
K
Chuman
Ken Kinjo, Toshiyuki Matsui, Takashi Hisabe, Hiroshi Ishihara, Shinichiro Maki, Kenta Chuman, Akihiro Koga, Kensei Ohtsu, Noritaka Takatsu, Fumihito Hirai, Kenshi Yao, Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka 818-8502, Japan.
Akihiro
A
Koga
Ken Kinjo, Toshiyuki Matsui, Takashi Hisabe, Hiroshi Ishihara, Shinichiro Maki, Kenta Chuman, Akihiro Koga, Kensei Ohtsu, Noritaka Takatsu, Fumihito Hirai, Kenshi Yao, Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka 818-8502, Japan.
Kensei
K
Ohtsu
Ken Kinjo, Toshiyuki Matsui, Takashi Hisabe, Hiroshi Ishihara, Shinichiro Maki, Kenta Chuman, Akihiro Koga, Kensei Ohtsu, Noritaka Takatsu, Fumihito Hirai, Kenshi Yao, Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka 818-8502, Japan.
Noritaka
N
Takatsu
Ken Kinjo, Toshiyuki Matsui, Takashi Hisabe, Hiroshi Ishihara, Shinichiro Maki, Kenta Chuman, Akihiro Koga, Kensei Ohtsu, Noritaka Takatsu, Fumihito Hirai, Kenshi Yao, Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka 818-8502, Japan.
Fumihito
F
Hirai
Ken Kinjo, Toshiyuki Matsui, Takashi Hisabe, Hiroshi Ishihara, Shinichiro Maki, Kenta Chuman, Akihiro Koga, Kensei Ohtsu, Noritaka Takatsu, Fumihito Hirai, Kenshi Yao, Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka 818-8502, Japan.
Kenshi
K
Yao
Ken Kinjo, Toshiyuki Matsui, Takashi Hisabe, Hiroshi Ishihara, Shinichiro Maki, Kenta Chuman, Akihiro Koga, Kensei Ohtsu, Noritaka Takatsu, Fumihito Hirai, Kenshi Yao, Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka 818-8502, Japan.
Masakazu
M
Washio
Aging; Colonic diverticular hemorrhage; Increase of incidence; Lower gastrointestinal bleeding