Preliminary studies: differences in microRNA expression in asthma and chronic obstructive pulmonary disease.
BACKGROUND
The asthma- and chronic obstructive pulmonary disease (COPD)-related morbidity has been increasing during the recent years. Both asthma and COPD are diseases of inflammatory etiology. The increasing interest in the pathomechanisms involved in the development of obstructive pulmonary diseases seems to be fully justified. Recent research has attempted to determine the associations of microRNA with the pathogenesis of pulmonary diseases.


OBJECTIVE
To assess the expression of microRNA in the blood sera of patients diagnosed with bronchial asthma and chronic obstructive pulmonary disease in comparison with healthy subjects.


METHODS
In our study, at the preliminary stage, we compared the expression of miRNA in the groups of patients with asthma and COPD versus the control group of healthy subjects.


RESULTS
A significant difference in hsa-miRNA-224, hsa-miRNA-339-5p, hsa-miRNA-382 in patients with asthma and COPD as compared with the controls was noted.


CONCLUSIONS
With such difference of expression of specific micro-RNA in serum of patient with asthma and COPD, those small non-coding RNA has to play a significant role in those diseases pathway. Therefore we expect to increase the size and differentation of the study groups in next studies.
Department of Pneumology and Allergology, Institute of Onternal Medicine, Medical University of Lodz, Lodz, Poland.
Małgorzata
M
Pietrusińska
Department of Pneumology and Allergology, Institute of Onternal Medicine, Medical University of Lodz, Lodz, Poland.
Aneta
A
Pająk
Department of Pneumology and Allergology, Institute of Onternal Medicine, Medical University of Lodz, Lodz, Poland.
Paweł
P
Górski
Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz, Lodz, Poland.
Piotr
P
Kuna
Department of Medical Biochemistry, Medical University of Lodz, Lodz, Poland.
Janusz
J
Szemraj
Department of General Pulmonology and Oncology, Medical University of Lodz, Lodz, Poland.
Agnieszka
A
Goździńska-Nielepkowicz
Department of Clinical Pharmacology, Medical University of Lodz, Lodz, Poland.
Tadeusz
T
Pietras
asthma; chronic obstructive pulmonary disease; microRNA; serum