Evaluation of posterior ocular changes using enhanced depth imaging-optical coherence tomography in patients with obstructive sleep apnea syndrome.
OBJECTIVE
Evaluation of the nerve fiber thicknesses of the macula, choroid, and retina using the apnea-hypopnea index in individuals with obstructive sleep apnea syndrome (OSAS) without systemic components.


METHODS
Prospective, controlled study. The central macular, choroidal, and retinal nerve fiber layer (RNFL) thicknesses were evaluated using enhanced depth imaging-spectral domain optical coherence tomography in individuals with OSAS. In people with severe OSAS who had received treatment, posterior ocular structures were examined over 3 months (4th and 12th weeks), and changes were evaluated. Only the right eyes of the participants were evaluated in the study.


RESULTS
A total of 72 people were involved in the study, with 18 in the control group and 19 with mild, 16 with moderate, and 19 with severe OSAS. No significant difference was found among the groups in terms of demographic measures. No significant differences were found among the groups in terms of the measures of central macular, central subfoveal choroidal (CSCT), temporal choroidal, nasal choroidal, and RNFL thicknesses. In severe OSAS cases in which treatment was administered, although subjective clinical recovery was observed, statistically significant thinning was detected during the 3-month follow-up period in the CSCT, general RNFL, as well as in the inferior and superior nasal quadrants, and temporal superior quadrant (p=0.005, p=0.009, p=0.039, p=0.003, and p=0.02, respectively).


CONCLUSIONS
In the group with severe OSAS, thinning in some posterior ocular tissues was observed. Although patients with severe OSAS may experience clinical recovery, we recommend that they would be followed up in terms of ocular ischemic injury.
Eye Clinic, Kayseri Training and Research Hospital Kayseri, Kayseri, Turkey.
İsa
İ
Yuvacı
Eye Clinic, Kayseri Training and Research Hospital Kayseri, Kayseri, Turkey.
Emine
E
Pangal
Eye Clinic, Kayseri Training and Research Hospital Kayseri, Kayseri, Turkey.
Nurettin
N
Bayram
Neurology Clinic, Kayseri Training and Research Hospital, Kayseri, Turkey.
Sevgi Arık
SA
Yüksel
Eye Clinic, Kayseri Training and Research Hospital Kayseri, Kayseri, Turkey.
Bedirhan
B
Alabay
Eye Clinic, Kayseri Training and Research Hospital Kayseri, Kayseri, Turkey.
Alperen
A
Ağadayı
Eye Clinic, Kayseri Training and Research Hospital Kayseri, Kayseri, Turkey.
Ender
E
Sırakaya
Eye Clinic, Kayseri Training and Research Hospital Kayseri, Kayseri, Turkey.
Ahmet
A
Gülhan
D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D002829:Choroid / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D005901:Glaucoma / Q000473:pathology; D006801:Humans; D007429:Intraocular Pressure; D008266:Macula Lutea / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D011446:Prospective Studies; D012160:Retina / Q000000981:diagnostic imaging* / Q000473:pathology; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000188:drug therapy / Q000473:pathology*; D018709:Statistics, Nonparametric; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000379:methods*; D016896:Treatment Outcome