N-glycans of growth factor receptors: their role in receptor function and disease implications.
Numerous signal-transduction-related molecules are secreted proteins or membrane proteins, and the mechanism by which these molecules are regulated by glycan chains is a very important issue for developing an understanding of the cellular events that transpire. This review covers the functional regulation of epidermal growth factor receptor (EGFR), ErbB3 and the transforming growth factor β (TGF-β) receptor by N-glycans. This review shows that the N-glycans play important roles in regulating protein conformation and interactions with carbohydrate recognition molecules. These results point to the possibility of a novel strategy for controlling cell signalling and developing novel glycan-based therapeutics.
Department of Biochemistry, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan takam@sapmed.ac.jp) dglycotani@riken.jp.
Motoko
M
Takahashi
Department of Biochemistry, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan Department of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan.
Yoshihiro
Y
Hasegawa
Systems Glycobiology Research Group, RIKEN-Max Planck Joint Research Center, Global Research Cluster, RIKEN, Wako 351-0198, Japan.
Congxiao
C
Gao
Department of Biochemistry, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan.
Yoshio
Y
Kuroki
Systems Glycobiology Research Group, RIKEN-Max Planck Joint Research Center, Global Research Cluster, RIKEN, Wako 351-0198, Japan takam@sapmed.ac.jp) dglycotani@riken.jp.
Naoyuki
N
Taniguchi
D000818:Animals; D005786:Gene Expression Regulation; D006031:Glycosylation; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D011134:Polysaccharides / Q000378:metabolism*; D017978:Receptors, Growth Factor / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
D036341:Intercellular Signaling Peptides and Proteins; D011134:Polysaccharides; D017978:Receptors, Growth Factor
EGFR; ErbB3; SP-D; TGF-β receptor; glycoform; glycosyltransferase