Effect of pregnancy-specific β1-glycoprotein on indoleamine-2,3-dioxygenase activity in human monocytes.
The role of heterogenic human pregnancy-specific glycoprotein (PSG), obtained by the authors' technology, in the regulation of the indoleamine-2,3-dioxygenase (IDO) activity in female blood monocytes has been studied in vitro. PSG stimulated IDO activity under the conditions of induction of the monocytes by interferon-γ. Upon the induction of cell proliferation by lipopolysaccharides, the stimulating effect was obtained only with 10 μg/mL of PSG. Enhanced IDO activity is probably a factor of peripheral immunological tolerance and antimicrobial protection against intracellular infections in the gestation period.
Institute of Ecology and Genetics of Microorganisms, Ural Division, Russian Academy of Sciences, Perm, Russia. mantissa7@mail.ru.|Perm State National Research University, Perm, Russia. mantissa7@mail.ru.
S A
SA
Zamorina
Institute of Ecology and Genetics of Microorganisms, Ural Division, Russian Academy of Sciences, Perm, Russia.
V P
VP
Timganova
Institute of Ecology and Genetics of Microorganisms, Ural Division, Russian Academy of Sciences, Perm, Russia.
M S
MS
Bochkova
Perm State National Research University, Perm, Russia.
P V
PV
Khramtsov
Institute of Ecology and Genetics of Microorganisms, Ural Division, Russian Academy of Sciences, Perm, Russia.|Yeltsin Ural Federal University, Yekaterinburg, Russia.
M B
MB
Raev
D000328:Adult; D005260:Female; D006801:Humans; D007108:Immune Tolerance; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000276:immunology* / Q000378:metabolism; D007371:Interferon-gamma / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D009000:Monocytes / Q000276:immunology* / Q000378:metabolism; D011247:Pregnancy / Q000097:blood / Q000276:immunology*; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000276:immunology* / Q000378:metabolism
C576710:IDO1 protein, human; C573415:IFNG protein, human; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D008070:Lipopolysaccharides; D011268:Pregnancy-Specific beta 1-Glycoproteins; D007371:Interferon-gamma