A Catalytic Intermolecular Formal Ene Reaction between Ketone-Derived Silyl Enol Ethers and Alkynes.
A catalytic formal ene reaction between ketone-derived silyl enol ethers and terminal alkynes is described. This transformation is uniquely capable of bimolecular assembly of 2-siloxy-1,4-dienes and can be used to access β,γ-unsaturated ketones containing quaternary carbons in the α-position.
Department of Chemistry, University of California , Irvine, California 92697-2025, United States.
Stephen D
SD
Holmbo
Department of Chemistry, University of California , Irvine, California 92697-2025, United States.
Nicole A
NA
Godfrey
Department of Chemistry, University of California , Irvine, California 92697-2025, United States.
Joshua J
JJ
Hirner
Department of Chemistry, University of California , Irvine, California 92697-2025, United States.
Sergey V
SV
Pronin