Epigenetic Control of Reprogramming and Transdifferentiation by Histone Modifications.
Somatic cells can be reprogrammed to pluripotent stem cells or transdifferentiate to another lineage cell type. Much efforts have been made to unravel the epigenetic mechanisms underlying the cell fate conversion. Histone modifications as the major epigenetic regulator are implicated in various aspects of reprogramming and transdifferentiation. Here, we discuss the roles of histone modifications on reprogramming and transdifferentiation and hopefully provide new insights into induction and promotion of the cell fate conversion by modulating histone modifications.
Tianjin Medical University, Tianjin, 300070, China.
Hua
H
Qin
Tianjin Medical University, Tianjin, 300070, China.
Andong
A
Zhao
Key Laboratory of Wound Repair and Regeneration of PLA, The First Hospital Affiliated to the PLA General Hospital, 51 Fu Cheng Road, Haidian District, Beijing, China.
Cuiping
C
Zhang
Key Laboratory of Wound Repair and Regeneration of PLA, The First Hospital Affiliated to the PLA General Hospital, 51 Fu Cheng Road, Haidian District, Beijing, China. fuxiaobing@vip.sina.com.
Xiaobing
X
Fu
D000818:Animals; D054338:Cell Transdifferentiation / Q000235:genetics*; D065150:Cellular Reprogramming / Q000235:genetics*; D044127:Epigenesis, Genetic; D042421:Histone Code; D006655:Histone Deacetylases / Q000378:metabolism; D056466:Histone Demethylases / Q000378:metabolism; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D054852:Small Molecule Libraries / Q000494:pharmacology
D054852:Small Molecule Libraries; D056466:Histone Demethylases; D006655:Histone Deacetylases
Cell fate conversion; Epigenetic; Histone modifications; Reprogramming; Somatic cells; Transdifferentiation; iPSCs