Fibrinolysis parameters in Sudanese women with severe preeclampsia.
BACKGROUND
Although preeclampsia remains a major cause of maternal and fetal morbidity and mortality, its pathogenesis is not fully understood. Coagulation and fibrinolysis changes were suggested to have a role in the pathogenesis of preeclampsia.


OBJECTIVE
A case-control study was conducted in Medani Hospital, Sudan, to investigate thrombin-activatable fibrinolysis inhibitor (TAFI) and plasminogen-activated inhibitor (PAI) in women with severe preeclampsia. Obstetrics and medical history was gathered using questionnaire. TAFI, PAI-1, and PAI-2 levels were measured using ELISA.


RESULTS
In comparison with the controls, women with severe preeclampsia had significantly higher levels [mean (SD)] of TAFI [3.4 (1.1) vs. 3.0(0.7) ng/ml, P = 0.019], PAI-1 [3.2 (1.3) vs. 2.5(1.0), IU/ml, P = 0.001], and significantly lower PAI-2 level [4.2(1.3) vs. 5.8(2.6) ng/ml, P < 0.001]. In linear regression, severe preeclampsia was significantly associated with TAFI (0.408 ng/ml, P = 0.038), PAI-1 (0.722, IU/ml P = 0.003), and PAI-2 (-1.745, ng/ml, P < 0.001).


CONCLUSIONS
The current study revealed a significant increase level of TAFI and PAI-1, coupled with a decrease in PAI-2 in women with severe preeclampsia in comparison with the control group.
a Faculty of Medical Laboratory Sciences , Al-ZaiemAl-Azhari University , Khartoum , Sudan.
Husham O
HO
Elzein
a Faculty of Medical Laboratory Sciences , Al-ZaiemAl-Azhari University , Khartoum , Sudan.
Abdel Rahim M
AR
Muddathir
a Faculty of Medical Laboratory Sciences , Al-ZaiemAl-Azhari University , Khartoum , Sudan.
Mohammed
M
Rida
b Faculty of Medicine , University of Khartoum , Khartoum , Sudan.
Duria A
DA
Rayis
c Faculty of Medicine , University of Geziera , Medani , Sudan.
Elhassan M
EM
Elhassan
b Faculty of Medicine , University of Khartoum , Khartoum , Sudan.
Ishag
I
Adam
D000328:Adult; D025901:Carboxypeptidase B2 / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D017396:Plasminogen Activator Inhibitor 2 / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis; D011247:Pregnancy; D012720:Severity of Illness Index; D013397:Sudan; D055815:Young Adult
D017395:Plasminogen Activator Inhibitor 1; D017396:Plasminogen Activator Inhibitor 2; C585364:CPB2 protein, human; D025901:Carboxypeptidase B2
Preeclampsia; Sudan; fibrinolysis; plasminogen; pregnancy; thrombin