Adsorption of viral particles from the blood plasma of patients with viral hepatitis on nanodiamonds.
Adsorption of viral particles from the blood plasma of patients with viral hepatitis B and C on modified nanodiamonds (MNDs) was shown in the in vitro experiments. PCR method showed the treatment of plasma with MNDs leads to a decrease in the viral load by 2-3 orders of magnitude or more in both cases studied. These results make it possible to predict the applicability of MNDs for the development of new technologies of hemodialysis and plasmapheresis for binding and removal of viral particles from the blood of infected patients.
Institute of Biophysics, Siberian Branch, Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russia. alexeybaron@mail.ru.|Siberian Federal University, Svobodnyi pr. 79, Krasnoyarsk, 660041, Russia. alexeybaron@mail.ru.
A V
AV
Baron
Krasnoyarsk Regional Center for Prevention and Control of AIDS, ul. Karla Marksa 47, Krasnoyarsk, 660049, Russia.
N V
NV
Osipov
Krasnoyarsk Regional Center for Prevention and Control of AIDS, ul. Karla Marksa 47, Krasnoyarsk, 660049, Russia.
S V
SV
Yashchenko
Krasnoyarsk Regional Center for Prevention and Control of AIDS, ul. Karla Marksa 47, Krasnoyarsk, 660049, Russia.
Yu A
YA
Kokotukha
Voino-Yasenetskii State Medical University, Ministry of Health of the Russian Federation, ul. Partizana Zheleznyaka 1, Krasnoyarsk, 660022, Russia.
I J
IJ
Baron
Institute of Biophysics, Siberian Branch, Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russia.
A P
AP
Puzyr
Krasnoyarsk Branch of Hematology Research Center, Ministry of Health of the Russian Federation, Krasnoyarsk, Russia.|Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences, Krasnoyarsk, 630036, Russia.
I A
IA
Olkhovskiy
Institute of Biophysics, Siberian Branch, Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russia.
V S
VS
Bondar
D000327:Adsorption; D004279:DNA, Viral / Q000097:blood; D006509:Hepatitis B / Q000097:blood* / Q000628:therapy*; D006526:Hepatitis C / Q000097:blood* / Q000628:therapy*; D006801:Humans; D058612:Nanodiamonds / Q000627:therapeutic use*; D010316:Particle Size; D010956:Plasmapheresis / Q000379:methods; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000097:blood; D006435:Renal Dialysis / Q000379:methods; D016896:Treatment Outcome; D019562:Viral Load; D014771:Virion / Q000378:metabolism*
D004279:DNA, Viral; D058612:Nanodiamonds; D012367:RNA, Viral