Interactive effect of 5-HTTLPR genotype and age on sources of cortical rhythms in healthy women.
This study was aimed to localize the effects of 5-HTTLPR (serotonin-transporter-linked polymorphic region) on the age differences of spontaneous EEG activity in women using neuroimaging analysis sLORETA (Standardized Low Resolution brain Electromagnetic Tomography). DNA samples extracted from cheek swabs and resting-state EEG recorded at 60 standard leads were collected from young (YW, N=86, 18-35years) and older (OW, N=45; 55-80years) healthy women. We have shown that advanced age was associated with increased posterior EEG desynchronization in S'/S'. S' (LG allele was grouped with S alleles owing to its functional equivalence and this group was labeled as S') genotype carriers denoted by decrease of delta - beta1 current source density, and to a lesser extent in L/L homozygotes denoted by decrease in delta activity. In heterozygotes OW, as compared with heterozygotes YW, higher source density estimates of beta1 in frontal and temporal cortex were observed. Age differences were more pronounced in the right hemisphere in S'/S' and L/L carriers and in the left hemisphere in heterozygotes. We also found that in OW, current source density estimates of theta, alpha1, alpha2, alpha3 and beta1 sources in the right occipital lobe were higher in S'/L than in S'/S' carriers. These results may have implications for understanding 5-HTT-dependent variation in the effect of aging on brain activity.
State Scientific-Research Institute of Physiology and Basic Medicine, Timakova Street 4, Novosibirsk 630117, Russia; Novosibirsk State University, Pirogova Street 2, Novosibirsk 630090, Russia.
Nina V
NV
Volf
State Scientific-Research Institute of Physiology and Basic Medicine, Timakova Street 4, Novosibirsk 630117, Russia. Electronic address: lv-belousova@physiol.ru.
Ludmila V
LV
Belousova
State Scientific-Research Institute of Physiology and Basic Medicine, Timakova Street 4, Novosibirsk 630117, Russia.
Gennady G
GG
Knyazev
Novosibirsk State University, Pirogova Street 2, Novosibirsk 630090, Russia; Institute of Cytology and Genetics of Siberian Branch of Russian Academy of Sciences, Prospekt Lavrentyeva, 10, Novosibirsk 630090, Russia.
Alexander V
AV
Kulikov
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D058256:Brain Waves / Q000235:genetics*; D002540:Cerebral Cortex / Q000502:physiology*; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D055815:Young Adult
C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins
5-HTTLPR; Electroencephalography; Women; sLORETA