Match of Solubility Parameters Between Oil and Surfactants as a Rational Approach for the Formulation of Microemulsion with a High Dispersed Volume of Copaiba Oil and Low Surfactant Content.
Aim was to formulate oil-in-water (O/W) microemulsion with a high volume ratio of complex natural oil, i.e. copaiba oil and low surfactant content. The strategy of formulation was based on (i) the selection of surfactants based on predictive calculations of chemical compatibility between their hydrophobic moiety and oil components and (ii) matching the HLB of the surfactants with the required HLB of the oil.



Solubility parameters of the hydrophobic moiety of the surfactants and of the main components found in the oil were calculated and compared. In turn, required HLB of oils were calculated. Selection of surfactants was achieved matching their solubility parameters with those of oil components. Blends of surfactants were prepared with HLB matching the required HLB of the oils. Oil:water mixtures (15:85 and 25:75) were the titrated with surfactant blends until a microemulsion was formed.



Two surfactant blends were identified from the predictive calculation approach. Microemulsions containing up to 19.6% and 13.7% of selected surfactant blends were obtained.



O/W microemulsions with a high volume fraction of complex natural oil and a reasonable surfactant concentration were formulated. These microemulsions can be proposed as delivery systems for the oral administration of poorly soluble drugs.
Université Paris-Sud, Institut Galien Paris Sud - UMR CNRS 8612 - Faculté de Pharmacie, 92296, Chatenay-Malabry Cedex, France.|Universidade Federal do Rio Grande do Norte, Centro de Ciências da Saúde, Departamento de Farmácia, Laboratório de Sistemas Dispersos (LaSiD), Av. Gal. Gustavo Cordeiro de Farias, S/N, Petrópolis, 59010-180, Natal, RN, Brazil.
Francisco Humberto
FH
Xavier-Junior
Université Paris-Sud, Institut Galien Paris Sud - UMR CNRS 8612 - Faculté de Pharmacie, 92296, Chatenay-Malabry Cedex, France.
Nicolas
N
Huang
Université Paris-Sud, Institut Galien Paris Sud - UMR CNRS 8612 - Faculté de Pharmacie, 92296, Chatenay-Malabry Cedex, France.
Jean-Jacques
JJ
Vachon
Universidade Estadual de Campinas (UNICAMP) - Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas. Rua Alexandre Cazelatto, 999, Vila Betel, Paulínia, SP, Brazil.
Vera Lucia Garcia
VL
Rehder
Universidade Federal do Rio Grande do Norte, Centro de Ciências da Saúde, Departamento de Farmácia, Laboratório de Sistemas Dispersos (LaSiD), Av. Gal. Gustavo Cordeiro de Farias, S/N, Petrópolis, 59010-180, Natal, RN, Brazil.
Eryvaldo Sócrates Tabosa
ES
do Egito
Université Paris-Sud, Institut Galien Paris Sud - UMR CNRS 8612 - Faculté de Pharmacie, 92296, Chatenay-Malabry Cedex, France. christine.vauthier@u-psud.fr.
Christine
0000-0003-3963-0045
C
Vauthier
D002626:Chemistry, Pharmaceutical; D003198:Computer Simulation; D004337:Drug Carriers; D004655:Emulsions; D007887:Fabaceae / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008956:Models, Chemical; D010316:Particle Size; D010938:Plant Oils / Q000737:chemistry*; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D004337:Drug Carriers; D004655:Emulsions; D010938:Plant Oils; D013501:Surface-Active Agents; D014867:Water
HLB; copaiba oil; microemulsion; oil-in-water; solubility parameters