Associations between peripheral blood eosinophil counts in patients with systemic sclerosis and disease severity.
Increased levels of serum pro-fibrotic cytokines have been reported in patients with systemic sclerosis (SSc). Some of these cytokines also play an important role in the differentiation and migration of eosinophils. The aim of this study was to determine whether eosinophilic inflammation is caused in SSc. We retrospectively reviewed the peripheral blood eosinophil counts in 70 untreated patients with SSc and compared them with those in patients with other major collagen diseases. We additionally evaluated a possible association with disease severity. Eosinophil counts were significantly higher levels in patients with SSc than in those with other collagen diseases, whereas total leukocyte counts were not. Eosinophil counts correlated positively with both severe interstitial lung disease (ILD; r = 0.255, p = 0.033) and modified Rodnan total skin thickness score (m-Rodnan TSS) in SSc (r = 0.347, p = 0.003), but did not correlate with ILD severity in other collagen diseases. In conclusion, peripheral eosinophil counts were higher in patients with SSc than in those with other collagen diseases and were correlated with increased disease severity. Our data suggest that eosinophilic inflammation is involved in the pathogenesis and progression of SSc.
Division of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421 Japan.
Katsutoshi
K
Ando
Department of Rheumatology, Kameda Medical Center, 929 Higashi-Cho, Kamogawa-City, Chiba 296-8602 Japan.
Tamao
T
Nakashita
Respiratory Internal Medicine, Kameda Medical Center, 929 Higashi-Cho, Kamogawa-City, Chiba 296-8602 Japan.
Norihiro
N
Kaneko
Division of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421 Japan.
Kazuhisa
K
Takahashi
Department of Rheumatology, Kameda Medical Center, 929 Higashi-Cho, Kamogawa-City, Chiba 296-8602 Japan.
Shinji
S
Motojima
Eosinophil; Interstitial lung disease; Systemic sclerosis; Treatment