Critical finger ischemia and myocardial fibrosis development after sudden interruption of sildenafil treatment in a systemic sclerosis patient.
Systemic sclerosis (SSc) is a connective tissue disease frequently associated with Raynaud's Phenomenon (RP). Among possible pharmacological treatments, phosphodiesterase 5 inhibitors are considered in cases of severe non -responsive RP. We present the case of a male SSc patient wh presented with critical finger ischemia and concomitant appearance of myocardial fibrosis after sudden interruption of sildenafil treatment.
Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Firenze. cosimobruni85@gmail.com.
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Bruni
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Bellando-Randone
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Gargani
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E
Picano
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Pingitore
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Matucci-Cerinic
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Guiducci
D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D009202:Cardiomyopathies / Q000209:etiology / Q000473:pathology*; D005385:Fingers / Q000098:blood supply*; D006801:Humans; D007511:Ischemia; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D011928:Raynaud Disease / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D012307:Risk Factors; D012595:Scleroderma, Systemic / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D000068677:Sildenafil Citrate / Q000009:adverse effects* / Q000627:therapeutic use; D013375:Substance Withdrawal Syndrome; D013997:Time Factors
D018501:Antirheumatic Agents; D000068677:Sildenafil Citrate