Acute Thermotherapy Prevents Impairments in Cutaneous Microvascular Function Induced by a High Fat Meal.
We tested the hypothesis that a high fat meal (HFM) would impair cutaneous vasodilation, while thermotherapy (TT) would reverse the detrimental effects. Eight participants were instrumented with skin heaters and laser-Doppler (LD) probes and tested in three trials: control, HFM, and HFM + TT. Participants wore a water-perfused suit perfused with 33°C (control and HFM) or 50°C (HFM + TT) water. Participants consumed 1 g fat/kg body weight. Blood samples were taken at baseline and two hours post-HFM. Blood pressure was measured every 5-10 minutes. Microvascular function was assessed via skin local heating from 33°C to 39°C two hours after HFM. Cutaneous vascular conductance (CVC) was calculated and normalized to maximal vasodilation (%CVCmax). HFM had no effect on initial peak (48 ± 4 %CVCmax) compared to control (49 ± 4 %CVCmax) but attenuated the plateau (51 ± 4 %CVCmax) compared to control (63 ± 4 %CVCmax, P < 0.001). Initial peak was augmented in HFM + TT (66 ± 4 %CVCmax) compared to control and HFM (P < 0.05), while plateau (73 ± 3 % CVCmax) was augmented only compared to the HFM trial (P < 0.001). These data suggest that HFM negatively affects cutaneous vasodilation but can be minimized by TT.
Department of Kinesiology & Health, Georgia State University, Atlanta, GA 30302-3975, USA.
Jennifer C
JC
Harvey
Department of Health & Kinesiology, Purdue University, West Lafayette, IN 47907, USA.
Bruno T
BT
Roseguini
Department of Kinesiology & Health, Georgia State University, Atlanta, GA 30302-3975, USA.
Benjamin M
BM
Goerger
Department of Kinesiology & Health, Georgia State University, Atlanta, GA 30302-3975, USA.
Elizabeth A
EA
Fallon
Department of Kinesiology & Health, Georgia State University, Atlanta, GA 30302-3975, USA.
Brett J
0000-0002-4763-0208
BJ
Wong
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose; D059305:Diet, High-Fat; D004041:Dietary Fats / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008297:Male; D062407:Meals; D012867:Skin / Q000098:blood supply*; D014280:Triglycerides / Q000097:blood; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*; D055815:Young Adult
D001786:Blood Glucose; D004041:Dietary Fats; D014280:Triglycerides