Magnetic isotope effect of magnesium (25)Mg on E. coli resistance to antibiotics.
Effects of synergism and antagonism of antibacterial drugs and magnetic isotope of magnesium (25)Mg on antibiotic resistance of bacteria E. coli were discovered. Fourteen antibiotics from seven different groups were tested. The increase in antibiotic resistance in the presence of the ion (25)Mg(2+) was discovered in E. coli cells incubated with quinolones/fluoroquinolones, indicating the inhibiting effect of the magnetic moments of nuclei (25)Mg on DNA synthesis. The change in antibiotic resistance was also detected in bacteria affected by magnesium (25)Mg and certain antibiotics from aminoglycoside and lincosamide groups.
Orenburg State University, pr. Pobedy 13, Orenburg, 460018, Russia. shevulyana@yandex.ru.
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Letuta
Orenburg State University, pr. Pobedy 13, Orenburg, 460018, Russia.
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Vekker
Orenburg State University, pr. Pobedy 13, Orenburg, 460018, Russia.
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Kornilova
Orenburg State University, pr. Pobedy 13, Orenburg, 460018, Russia.
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Gryaznov
Orenburg State University, pr. Pobedy 13, Orenburg, 460018, Russia.
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Cheplakov
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002413:Cations, Divalent; D003470:Culture Media; D004261:DNA Replication / Q000187:drug effects; D024881:Drug Resistance, Bacterial / Q000502:physiology*; D004926:Escherichia coli / Q000187:drug effects* / Q000378:metabolism*; D007554:Isotopes; D008274:Magnesium / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D002413:Cations, Divalent; D003470:Culture Media; D007554:Isotopes; D008274:Magnesium