Molecular pathways driving disease-specific alterations of intestinal epithelial cells.
Due to the fact that chronic inflammation as well as tumorigenesis in the gut is crucially impacted by the fate of intestinal epithelial cells, our article provides a comprehensive overview of the composition, function, regulation and homeostasis of the gut epithelium. In particular, we focus on those aspects which were found to be altered in the context of inflammatory bowel diseases or colorectal cancer and also discuss potential molecular targets for a disease-specific therapeutic intervention.
Department of Medicine 1, Friedrich-Alexander-University Erlangen-Nuremberg, Ulmenweg 18, 91054, Erlangen, Germany.
Rocío
R
López-Posadas
Department of Medicine 1, Friedrich-Alexander-University Erlangen-Nuremberg, Ulmenweg 18, 91054, Erlangen, Germany.
Markus F
MF
Neurath
Department of Medicine 1, Friedrich-Alexander-University Erlangen-Nuremberg, Ulmenweg 18, 91054, Erlangen, Germany. imke.atreya@uk-erlangen.de.
Imke
0000-0002-2708-9688
I
Atreya
D000818:Animals; D004194:Disease / Q000235:genetics*; D004847:Epithelial Cells / Q000378:metabolism*; D006801:Humans; D007422:Intestines / Q000166:cytology*; D009154:Mutation / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics*; D019108:Tight Junctions / Q000378:metabolism
Colitis-associated cancer; Colorectal cancer; Epithelial integrity; Inflammatory bowel diseases; Intestinal epithelial cells