Time-Course of Changes in Choroidal Thickness after Complete Mydriasis Induced by Compound Tropicamide in Children.
OBJECTIVE
The aim of this study was to investigate the time-course of changes in choroidal thickness (ChT) following complete mydriasis induced by compound tropicamide.


METHODS
ChT was measured by OCT with the enhanced-depth imaging technique (Spectralis HRA+OCT, Heidelberg Engineering, Germany) at nine locations of the fundus: subfoveal ChT (SFChT) and ChT at 1 mm and 3 mm from the fovea in four quadrants. Mydriasis was induced with compound tropicamide (0.5% tropicamide plus 0.5% phenylephrine hydrochloride, three doses at 5-minute intervals). Measurements were conducted prior to the instillation and at 0, 30, and 60 min following complete mydriasis. Results at different time-points were compared using repeated-measures ANOVA to investigate the time-course of the changes.


RESULTS
Thirty-nine subjects (mean age 11.9±2 years; 16 males and 23 females) were enrolled in the study. Compound tropicamide resulted in a statistically significant decrease in SFChT at 0, 30, and 60 min after complete mydriasis, as compared to baseline (-5±4 μm, -12±4 μm, and -13±4 μm, respectively; all P<0.0001). No significant changes were detected in the parafoveal choroid except at 1 mm temporal (T1mm) and nasal (N1mm) to the fovea at 30 and 60 min (T1mm: -6±4 μm and -7±5 μm at 30 and 60 min; N1mm: -6±4 μm and -7±5 μm at 30 and 60 min, respectively; all P<0.0001). Repeated-measures ANOVA showed a significant interaction between the time after complete mydriasis and the effect of the mydriasis agent.


CONCLUSIONS
Complete mydriasis induced by compound tropicamide led to choroidal thinning, and the magnitude varied over time.
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Zhouyue
http://orcid.org/0000-0002-1069-0581
Z
Li
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Junwen
J
Zeng
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Wei
W
Jin
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Wen
W
Long
Optometry and Visual Science Institute, Aier Eye Hospital Group, Changsha, Hunan Province, China.|State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Weizhong
W
Lan
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Xiao
X
Yang
D060433:Administration, Ophthalmic; D000293:Adolescent; D002648:Child; D002829:Choroid / Q000187:drug effects* / Q000473:pathology; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D009184:Mydriatics / Q000008:administration & dosage* / Q000009:adverse effects; D013997:Time Factors; D041623:Tomography, Optical Coherence; D014331:Tropicamide / Q000008:administration & dosage* / Q000009:adverse effects
D009184:Mydriatics; D014331:Tropicamide