Divisions of Identified Parvalbumin-Expressing Basket Cells during Working Memory-Guided Decision Making.
Parvalbumin-expressing basket cells tightly control cortical networks and fire remarkably stereotyped during network oscillations and simple behaviors. How can these cells support multifaceted situations with different behavioral options and complex temporal sequences? We recorded from identified parvalbumin-expressing basket cells in prefrontal cortex of freely moving rats performing a multidimensional delayed cue-matching-to-place task, juxtacellularly filled recorded neurons for unequivocal histological identification, and determined their activity during temporally structured task episodes, associative working-memory, and stimulus-guided choice behavior. We show that parvalbumin-expressing basket cells do not fire homogenously, but individual cells were recruited or inhibited during different task episodes. Firing of individual basket cells was correlated with amount of presynaptic VIP (vasoactive intestinal polypeptide)-expressing GABAergic input. Together with subsets of pyramidal neurons, activity of basket cells differentiated for sequential actions and stimulus-guided choice behavior. Thus, interneurons of the same cell type can be recruited into different neuronal ensembles with distinct firing patterns to support multi-layered cognitive computations.
Department of Cognitive Neurobiology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A-1090, Vienna, Austria. Electronic address: michael.lagler@meduniwien.ac.at.
Michael
M
Lagler
Department of Cognitive Neurobiology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A-1090, Vienna, Austria.
A Tugrul
AT
Ozdemir
Department of Cognitive Neurobiology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A-1090, Vienna, Austria.
Sabria
S
Lagoun
Department of Cognitive Neurobiology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A-1090, Vienna, Austria.
Hugo
H
Malagon-Vina
Department of Cognitive Neurobiology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A-1090, Vienna, Austria.
Zsolt
Z
Borhegyi
Department of Cognitive Neurobiology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A-1090, Vienna, Austria.
Romana
R
Hauer
Department of Cognitive Neurobiology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A-1090, Vienna, Austria.
Anna
A
Jelem
Department of Cognitive Neurobiology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A-1090, Vienna, Austria. Electronic address: thomas.klausberger@meduniwien.ac.at.
Thomas
T
Klausberger
D000818:Animals; D002755:Choice Behavior / Q000502:physiology; D003657:Decision Making / Q000502:physiology*; D059330:GABAergic Neurons / Q000378:metabolism / Q000502:physiology; D007395:Interneurons / Q000378:metabolism / Q000502:physiology*; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D010320:Parvalbumins / Q000378:metabolism*; D017397:Prefrontal Cortex / Q000502:physiology; D017729:Presynaptic Terminals / Q000378:metabolism; D017966:Pyramidal Cells / Q000502:physiology; D051381:Rats; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism
D010320:Parvalbumins; D014660:Vasoactive Intestinal Peptide