Alternative functions for the multifarious inflammasome.
The inflammasome has been mainly studied in innate immune cells in which it senses microbes and cellular damage, and induces secretion of pro-inflammatory cytokines. This process induces an inflammatory response that is critical for the resolution of infections and repair of tissue damage following injury. Recent studies indicate that inflammasome complex formation also participates in many other cellular and physiological processes beyond modulation of inflammation, such as autophagy, metabolism, eicosanoids production, and phagosome maturation.
Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan; Laboratory of Nanomaterials, Chang Gung University, Taoyuan, Taiwan.
Jan
J
Martel
Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan; Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Research Center of Bacterial Pathogenesis, Chang Gung University, Taoyuan, Taiwan; Department of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Research Center for Industry of Human Ecology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan; Graduate Institute of Health Industry and Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan.
Hsin-Chih
HC
Lai
Biochemical Engineering Research Center, Ming Chi University of Technology, New Taipei City, Taiwan.
Yun-Fei
YF
Ko
Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan; Laboratory of Nanomaterials, Chang Gung University, Taoyuan, Taiwan; Biochemical Engineering Research Center, Ming Chi University of Technology, New Taipei City, Taiwan; Laboratory of Cellular Physiology and Immunology, Rockefeller University, NY, USA.
John D
JD
Young
Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan; Department of Biomedical Sciences, University of the Pacific, Arthur Dugoni School of Dentistry, San Francisco, CA, USA. Electronic address: dojcius@pacific.edu.
David M
DM
Ojcius
D000818:Animals; D001343:Autophagy / Q000276:immunology*; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D058847:Inflammasomes / Q000276:immunology*; D007249:Inflammation / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*
D016207:Cytokines; D058847:Inflammasomes
Autophagy; Inflammation; Innate immunity; NLRP3; Non-canonical inflammasome