Oxytocin modulation of neural circuits for social behavior.
Oxytocin is a hypothalamic neuropeptide that has gained attention for the effects on social behavior. Recent findings shed new light on the mechanisms of oxytocin in synaptic plasticity and adaptively modifying neural circuits for social interactions such as conspecific recognition, pair bonding, and maternal care. Here, we review several of these newer studies on oxytocin in the context of previous findings, with an emphasis on social behavior and circuit plasticity in various brain regions shown to be enriched for oxytocin receptors. We provide a framework that highlights current circuit-level mechanisms underlying the widespread action of oxytocin. © 2016 Wiley Periodicals, Inc. Develop Neurobiol 77: 169-189, 2017.
Department of Neuroscience, Columbia University, New York, New York, 10032.|Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York, 10032.
Bianca J
BJ
Marlin
Department of Otolaryngology, Skirball Institute for Biomolecular Medicine, Neuroscience Institute, New York University School of Medicine, New York, New York.|Department of Neuroscience and Physiology Skirball Institute for Biomolecular Medicine, Neuroscience Institute New York University School of Medicine, New York, New York.|Center for Neural Science, New York University, New York, New York.
Robert C
RC
Froemke
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*; D010121:Oxytocin / Q000502:physiology*; D012919:Social Behavior
D010121:Oxytocin
cortex; inhibition; neural circuits; oxytocin; synaptic plasticity