Copper Nitrate Mediated Regio- and Stereoselective Difunctionalization of Alkynes: A Direct Approach to α-Chloro-β-nitroolefins.
An efficient copper nitrate mediated chloronitration reaction was developed for the direct synthesis of α-chloro-β-nitroolefins with high regio- and stereoselectivity from simple alkynes and low toxic stannous chloride. This protocol provides a direct access to polysubstituted alkenes with operational simplicity, good functional group tolerance, and a wide substrate scope. Various applications of given products allowed the straightforward assembly of molecular complexity and indicated them as promising and valuable building blocks in organic synthesis.
School of Materials Science and Engineering, Department of Chemistry, Innovative Drug Research Center, Shanghai University , Shanghai 200444, China.
Mingchun
M
Gao
School of Materials Science and Engineering, Department of Chemistry, Innovative Drug Research Center, Shanghai University , Shanghai 200444, China.|State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , Shanghai 200032, China.|Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University , Shanghai 200062, China.
Bin
B
Xu