In vitro and in silico investigation of electrospun terbinafine hydrochloride-loaded buccal nanofibrous sheets.
Terbinafine hydrochloride-loaded nanofibrous buccal films were formulated with the aim to improve the solubility and dissolution behavior; thus, the local effectiveness of the antifungal agent. Poly(vinyl alcohol) and chitosan polymer composites were selected as delivery base in order to enhance the mucoadhesion of the fibrous films. The dissolution of terbinafine hydrochloride was carried out applying a stainless steel disc assembly and the terbinafine concentration was determined by HPLC-MS in selective ion monitoring mode. The prediction of the absorption behavior of the prepared fibrous samples in the human oral cavity was modeled using GastroPlus™ software. The result indicates that the fibrous films enabled fast and complete dissolution of the active agent. The drug absorption from the oral cavity could be minimized by the employment of the proper oral transit model. Because of the limited absorption of terbinafine hydrochloride from the oral mucosa the formulation can be beneficial in local administration in the case of hold and expectorate administration mode.
Gedeon Richter Plc., Formulation R&D, Gyömrői Str. 19-21, H-1103 Budapest, Hungary; University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes Endre Str. 7-9, H-1092 Budapest, Hungary.
Péter
P
Szabó
Gedeon Richter Plc., Formulation R&D, Gyömrői Str. 19-21, H-1103 Budapest, Hungary.
Tünde Beáta
TB
Daróczi
Department of Pharmaceutical Chemistry, Semmelweis University, Hőgyes Endre Str. 7, H-1092 Budapest, Hungary.
Gergő
G
Tóth
University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes Endre Str. 7-9, H-1092 Budapest, Hungary. Electronic address: zelko.romana@pharma.semmelweis-univ.hu.
Romána
R
Zelkó
D000268:Adhesiveness; D000278:Administration, Buccal; D048271:Chitosan / Q000737:chemistry; D003198:Computer Simulation; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D065546:Drug Liberation; D005782:Gels / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D066298:In Vitro Techniques; D009055:Mouth / Q000378:metabolism; D057139:Nanofibers; D009281:Naphthalenes / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D011142:Polyvinyl Alcohol / Q000737:chemistry; D012995:Solubility; D000077291:Terbinafine
D004337:Drug Carriers; D005782:Gels; D009281:Naphthalenes; D011142:Polyvinyl Alcohol; D048271:Chitosan; D000077291:Terbinafine
Buccal fibrous sheet; Electrospinning; In silico absorption modeling; In vitro drug release; Nanofiber; Terbinafine hydrochloride