Pyrrole Oligoglycosides from the Starfish Acanthaster planci Suppress Lipopolysaccharide-Induced Nitric Oxide Production in RAW264.7 Macrophages.
Two new pyrrole oligoglycosides, plancipyrrosides A and B (1 and 2), were isolated from methanol extract of the Vietnamese starfish Acanthaster planci using various chromatographic procedures. Their structures were elucidated by spectroscopic methods including one and two dimensional (1D- and 2D)-NMR and Fourier transform ion cyclotron resonance (FT-ICR)-MS. The finding of 1 and 2 represents the third case of pyrrole oligoglycosides obtaining reported to date. Moreover, plancipyrroside B (2) exhibits a potent inhibitory effect on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells with IC50of 5.94±0.34 µM, whereas plancipyrroside A (1) shows this inhibitory activity with IC50of 16.61±1.85 µM.
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST).
Le Thi
LT
Vien
Tran Thi Hong
TT
Hanh
Phan Thi Thanh
PT
Huong
Nguyen Hai
NH
Dang
Nguyen Van
NV
Thanh
Ekaterina
E
Lyakhova
Nguyen Xuan
NX
Cuong
Nguyen Hoai
NH
Nam
Phan Van
PV
Kiem
Alla
A
Kicha
Chau Van
CV
Minh
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008968:Molecular Conformation; D009569:Nitric Oxide / Q000096:biosynthesis*; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013215:Starfish / Q000737:chemistry*
D006027:Glycosides; D008070:Lipopolysaccharides; D011758:Pyrroles; D009569:Nitric Oxide