Detection of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans after Systemic Administration of Amoxicillin Plus Metronidazole as an Adjunct to Non-surgical Periodontal Therapy: A Systematic Review and Meta-Analysis.
OBJECTIVE
To evaluate the variations in the detection of Porphyromonas gingivalis and/or Aggregatibacter actinomycetemcomitans before and after systemic administration of amoxicillin plus metronidazole in association with non-surgical periodontal therapy (NSPT).


BACKGROUND
The adjunctive use of antibiotics has been advocated to improve the clinical outcomes of NSPT. However, no systematic review has investigated the microbiological benefit of this combination.


METHODS
An electronic search was conducted up to December 2015. Randomized clinical trials comparing the number of patients testing positive for P. gingivalis and/or A. actinomycetemcomitans before and after NSPT with (test group) or without (control group) amoxicillin plus metronidazole were included. The difference between groups in the variation of positive patients was calculated using the inverse variance method with a random effects model.


RESULTS
The frequency of patients positive for A. actinomycetemcomitans was decreased by 30% (p = 0.002) and by 25% (p = 0.01) in the test group compared to the control group at 3- and 6-month follow-up, respectively. Similar findings were observed when considering the frequency of patients positive for Porphyromonas gingivalis, with a reduction by 28% (p < 0.0001), 32% (p < 0.0001), and 34% (p = 0.03) in the test group compared to the control group at 3-, 6-, and 12-month follow-up, respectively.


CONCLUSIONS
The systemic administration of amoxicillin plus metronidazole as an adjunct to NSPT significantly decreased the number of patients positive for P. gingivalis and A. actinomycetemcomitans compared with periodontal therapy alone or with a placebo.
Department of Periodontology, Service of Odontology, U.F.R. of Odontology, Rothschild Hospital, AP-HP, Paris Diderot University Paris, France.
Aleksandar
A
Dakic
Department of Periodontology, Service of Odontology, U.F.R. of Odontology, Rothschild Hospital, AP-HP, Paris Diderot UniversityParis, France; UMS 011, Population-based Epidemiologic Cohorts Unit, Institut National de la Santé et de la Recherche MédicaleVillejuif, France.
Adrien
A
Boillot
Department of Periodontology, Service of Odontology, U.F.R. of Odontology, Rothschild Hospital, AP-HP, Paris Diderot University Paris, France.
Cyrille
C
Colliot
Department of Periodontology, Service of Odontology, U.F.R. of Odontology, Rothschild Hospital, AP-HP, Paris Diderot UniversityParis, France; UMS 011, Population-based Epidemiologic Cohorts Unit, Institut National de la Santé et de la Recherche MédicaleVillejuif, France.
Maria-Clotilde
MC
Carra
UMS 011, Population-based Epidemiologic Cohorts Unit, Institut National de la Santé et de la Recherche MédicaleVillejuif, France; Department of Nutrition, Hôpital Européen Georges Pompidou, AP-HP, Paris Descartes UniversityParis, France.
Sébastien
S
Czernichow
Department of Periodontology, Service of Odontology, U.F.R. of Odontology, Rothschild Hospital, AP-HP, Paris Diderot UniversityParis, France; EA 2496, U.F.R. of Odontology, Paris Descartes UniversityMontrouge, France.
Philippe
P
Bouchard
Aggregatibacter actinomycetemcomitans; Porphyromonas gingivalis; amoxicillin; meta-analysis; metronidazole; periodontitis/therapy