Changes in circulating levels of fibroblast growth factor 23 induced by short-term dietary magnesium deficiency in rats.
Fibroblast growth factor 23 (FGF23) is a potent regulator of phosphorus (P) and vitamin D metabolism. Long-term dietary magnesium (Mg) deficiency increases circulating levels of FGF23, whereas the effects of short-term dietary Mg deficiency are unclear. Thus, the present study investigated whether short-term dietary Mg deficiency affects circulating levels of FGF23. We also assessed changes in renal mRNA expression of vitamin D metabolizing enzymes and type II sodium-phosphate (Na/Pi) cotransporters, since these are regulated by FGF23. Rats were fed a control diet (control group) or an Mg-deficient diet (Mg-deficient group) for 2, 4 or 7 days. Serum Mg levels were significantly lower in the Mg-deficient group than in the control group at all time points. Serum FGF23 levels were significantly higher in the Mg-deficient group than in the control group at day 7. The 25-hydroxyvitamin D-24-hydroxylase (24(OH)ase) mRNA levels were significantly higher in the Mg-deficient group than in the control group at day 7 . No significant differences in types IIa and IIc Na/Pi cotransporter mRNA levels were observed between the control and Mg-deficient groups. These results suggest that dietary Mg deficiency causes a rapid increase in circulating levels of FGF23 and renal 24(OH)ase mRNA levels.
Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo 156-8502, Japan, Department of Food and Nutritional Science, Graduate School of Agriculture, Graduate School of Tokyo University of Agriculture, Tokyo 156-8502, Japan.
Hiroshi
H
Matsuzaki
Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo 156-8502, Japan, Department of Food and Nutritional Science, Graduate School of Agriculture, Graduate School of Tokyo University of Agriculture, Tokyo 156-8502, Japan.
Shinichi
S
Katsumata
Department of Food and Nutritional Science, Graduate School of Agriculture, Graduate School of Tokyo University of Agriculture, Tokyo 156-8502, Japan.
Yoshiaki
Y
Maeda
Department of Food Sciences, College of Life Sciences, Ibaraki Christian University, Ibaraki 319-1295, Japan.
Yasutaka
Y
Kajita
D000818:Animals; D004032:Diet; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood*; D008275:Magnesium Deficiency / Q000097:blood*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23
fibroblast growth factor 23; rats; short-term dietary magnesium deficiency; type II sodium-phosphate cotransporter; vitamin D metabolizing enzyme