Influence of the use of testosterone associated with physical training on some hematologic and physical parameters in older rats with alloxan-induced diabetes.
OBJECTIVE
This study investigated the possible blood changes in wistar rats elderly with and without treatment with anabolic steroids submitted physical training.


METHODS
Elderly rats (32) were divided into four groups: normal (N), treated normal (NT), diabetic (D) and treated diabetic (DT). They were submitted to 20 sessions of swimming with overload (5% body weight), 40 min/day for four weeks. The NT and DT groups received application of testosterone twice a week. At the end of the sessions, the animals were subjected to swimming until exhaustion and then killed for removal of blood and visceral fat. We evaluated maximum swim time, weight of visceral fat, erythrogram, leukogram, lipidogram and serum levels of glucose, lactate, aspartate aminotransferase and creatine kinase. The results were compared using one-way ANOVA followed by the post hoc Tukey test.


RESULTS
In elderly diabetic rats, the use of anabolic associated with physical training in older rats resulted in improvement in erythrogram, lipidogram and physical performance for high-intensity aerobic exercise. However, it was related to changes in leukocyte count, probably associated with inflammation.


CONCLUSIONS
The combination of the use of testosterone with physical training, followed by maximal effort test caused changes hematological and biochemical can be associated with improvement in physiological characteristics, with increase of the swimming time and decrease of visceral fat levels, improvement in aerobic metabolism of fatty acids and glucose in normal and diabetic animals.
Centro de Ciências da Saúde e Desporto, Universidade Federal do Acre (UFAC), Rio Branco, AC, Brasil.|Centro Universitário do Planalto de Araxá (Uniaraxá), Araxá, MG, Brasil.
Romeu Paulo Martins
RP
Silva
Centro Universitário do Planalto de Araxá (Uniaraxá), Araxá, MG, Brasil.
Rodrigo Otávio Dos
RO
Santos
Centro Universitário do Planalto de Araxá (Uniaraxá), Araxá, MG, Brasil.
Nelson Eurípedes
NE
Matildes
Instituto de Genética e Bioquímica, Universidade Federal de Uberlândia (UFU), Uberlândia, MG, Brasil.
Antônio Vicente
AV
Mundim
Instituto de Genética e Bioquímica, Universidade Federal de Uberlândia (UFU), Uberlândia, MG, Brasil.
Mario da Silva
MD
Garrote-Filho
Centro Universitário do Planalto de Araxá (Uniaraxá), Araxá, MG, Brasil.
Pâmella Ferreira
PF
Rodrigues
Instituto de Genética e Bioquímica, Universidade Federal de Uberlândia (UFU), Uberlândia, MG, Brasil.
Nilson
N
Penha-Silva
D000818:Animals; D001774:Blood Chemical Analysis; D001786:Blood Glucose / Q000032:analysis*; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000503:physiopathology / Q000628:therapy; D008297:Male; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming / Q000502:physiology*; D013739:Testosterone / Q000008:administration & dosage*
D001786:Blood Glucose; D013739:Testosterone