Breast Cancer Metastasis Suppressor 1 (BRMS1): Robust Biological and Pathological Data, But Still Enigmatic Mechanism of Action.
Metastasis requires coordinated expression of multiple genetic cassettes, often via epigenetic regulation of gene transcription. BRMS1 blocks metastasis, but not orthotopic tumor growth in multiple tumor types, presumably via SIN3 chromatin remodeling complexes. Although there is an abundance of strong data supporting BRMS1 as a metastasis suppressor, the mechanistic data directly connecting molecular pathways with inhibition of particular steps in metastasis are not well defined. In this review, the data for BRMS1-mediated metastasis suppression in multiple tumor types are discussed along with the steps in metastasis that are inhibited.
University of Kansas Medical Center; Kansas City, KS, United States; University of Kansas Cancer Center, Kansas City, KS, United States. Electronic address: dwelch@kumc.edu.
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DR
Welch
University of Kansas Medical Center; Kansas City, KS, United States.
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Manton
University of Alabama at Birmingham, Birmingham, AL, United States. Electronic address: dhurst@uab.edu.
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DR
Hurst
D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D012097:Repressor Proteins / Q000378:metabolism*
C410024:BRMS1 protein, human; D012097:Repressor Proteins
Adhesion; BRMS1; Chromatin; Epigenetic; HDAC; Histone deacetylase; Invasion; Metastasis suppression; Microenvironment; NFkB; SIN3