Viral Hepatitis and Diabetes: Clinical Implications of Diabetes Prevention Through Hepatitis Vaccination.
Viral hepatitis has been posited to play a role in the development of type 2 diabetes. Thus, prevention of viral hepatitis through vaccination has the potential to reduce the burden of type 2 diabetes. We have shown that successful hepatitis B vaccination reduces the risk of diabetes by 33 %. Although diabetes can be prevented by behavior modification and pharmaceutical agents, these require significant personal commitment and cost. In contrast, diabetes prevention through hepatitis B vaccination would require little personal commitment and relatively low cost. In this review, we discuss hepatitis viruses A, B, and C and their interaction with diabetes; explore the potential underlying mechanisms and potential for hepatitis vaccination to reduce diabetes; and estimate the medical expense savings that would result from such an intervention. Given the projected increase of diabetes prevalence in the developing regions, where hepatitis B is endemic, exploration of such an intervention is very timely.
Division of Endocrinology, Metabolism and Genetics, Department of Internal Medicine, University of Kansas Medical Center, Kansas, KS, USA.
Rudruidee
R
Karnchanasorn
Division of Endocrinology and Metabolism, Department of Internal Medicine, National Cheng-Kung University Medical College and Hospital, Tainan, Taiwan.
Horng-Yih
HY
Ou
Department of Gastroenterology, City of Hope National Medical Center, Duarte, CA, USA.
James
J
Lin
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.|Graduate Institute of Preventive Medicine, School of Public Health, National Taiwan University, Taipei, Taiwan.
Lee-Ming
LM
Chuang
Department of Clinical Diabetes, Endocrinology, and Metabolism, City of Hope National Medical Center, Duarte, CA, 91010-3000, USA. kchiu@coh.org.|Division of Endocrinology, Metabolism and Nutrition, Department of Internal Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA. kchiu@coh.org.
Ken C
KC
Chiu
D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000517:prevention & control*; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006525:Hepatitis, Viral, Human / Q000150:complications*; D006801:Humans; D014611:Vaccination
D017325:Hepatitis B Vaccines
Diabetes mellitus; Diabetes prevention; Hepatitis; Liver; Vaccination