Late-life Depression and Alzheimer Disease: A Potential Synergy of the Underlying Mechanisms.
A number of biological and clinical characteristics typical of late life depression (LLD) have been suggested by recent research findings. The close association of LLD with cognitive impairment is now well documented and evidenced. However, it is still not clear whether it is depression that leads to cognitive decline, and in more severe cases, to dementia. The work presented in this review article suggests that depression and dementia frequently and strongly copresent, even if the causality remains largely opaque.
Department of Psychiatry, Wroclaw Medical University, Pasteura 10, Str.,50-368 Wroclaw, Poland.
Jerzy
J
Leszek
Department of Psychiatry, Wroclaw Medical University, Pasteura 10, Str.,50-368 Wroclaw, Poland.
Elżbieta
E
Trypka
Medical School, Aristotle University, Thessaloniki, Greece.
Euphrosyni
E
Koutsouraki
Medical School, Aristotle University, Thessaloniki, Greece.
Dimitrios
D
Michmizos
Department of Biochemistry and Bioinformatics, Institute of Science, GITAM University, Visakhapatnam, Andhra Pradesh, 530045, India.
Nagendra Sastry
NS
Yarla
Sechenov First Moscow State Medical University, 119991, Moscow, Russian Federation.
Vadim V
VV
Tarasov
King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
Ghulam Md
GM
Ashraf
Sechenov First Moscow State Medical University, 119991, Moscow, Russian Federation.|GALLY International Biomedical Research Consulting LLC., 7733 Louis Pasteur Drive, #330, San Antonio, TX, 78229, United States.|School of Health Science and Healthcare Administration, University of Atlanta, E. Johns Crossing, #175, Johns Creek, GA, United States.|Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russian Federation.
Gjumrakch
G
Aliev
D000544:Alzheimer Disease / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D003863:Depression / Q000150:complications / Q000453:epidemiology / Q000473:pathology*; D005938:Glucocorticoids / Q000097:blood / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000473:pathology; D010913:Pituitary-Adrenal System / Q000378:metabolism; D017397:Prefrontal Cortex / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism
D019208:Brain-Derived Neurotrophic Factor; D016207:Cytokines; D005938:Glucocorticoids; D011960:Receptors, Estrogen
Aging; Alzheimer disease; BDNF late-life depression; dementia; depression.