HIV, Aging, and Viral Coinfections: Taking the Long View.
Viral suppression of human immunodeficiency virus (HIV) with combination antiviral therapy (cART) has led to increasing longevity but has not enabled a complete return to health among aging HIV-infected individuals (HIV+). Viral coinfections are prevalent in the HIV+ host and are implicated in cancer, liver disease, and accelerated aging. We must move beyond a simplistic notion of HIV becoming a "chronic controllable illness" and develop an understanding of how viral suppression alters the natural history of HIV infection, especially at the intersection of HIV with other common viral coinfections in the context of an altered, aging immune system.
Section of Digestive Diseases, VA Connecticut-Healthcare System, West Haven, CT, USA.|Section of Digestive Diseases, Yale University School of Medicine, 333 Cedar St., PO Box 208019, New Haven, CT, 06520-8019, USA.
Tamar H
TH
Taddei
Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.|Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School, 836 Blockley Hall, 423 Guardian Drive, Philadelphia, PA, 19104-6021, USA.
Vincent
V
Lo Re
Veterans Aging Cohort Study Coordinating Center, VA Connecticut Healthcare System, West Haven, CT, USA. amy.justice2@va.gov.|Division of General Internal Medicine, Yale University School of Medicine, New Haven, CT, USA. amy.justice2@va.gov.|Center for Interdisciplinary Research on AIDS, Yale University School of Public Health, New Haven, CT, USA. amy.justice2@va.gov.|Yale School of Medicine, Building 35A, Room 2-212 (11-ACSLG), 950 Campbell Avenue, West Haven, CT, 06516, USA. amy.justice2@va.gov.
Amy C
AC
Justice
D000375:Aging / Q000276:immunology*; D019380:Anti-HIV Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D060085:Coinfection / Q000276:immunology* / Q000821:virology; D024882:Drug Resistance, Viral; D015658:HIV Infections / Q000150:complications* / Q000276:immunology / Q000503:physiopathology; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000276:immunology / Q000503:physiopathology; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D007165:Immunosuppression Therapy; D008113:Liver Neoplasms / Q000473:pathology / Q000821:virology; D015995:Prevalence; D016896:Treatment Outcome; D019562:Viral Load
D019380:Anti-HIV Agents; D000998:Antiviral Agents
Aging; Cancer; Coinfection; HIV; HPV; Liver disease; Viral hepatitis