Corticotropin-Releasing Factor Receptors and Their Interacting Proteins: Functional Consequences.
The corticotropin-releasing factor (CRF) system, which is involved in stress, addiction, and anxiety disorders such as depression, acts through G-protein-coupled receptors (GPCRs) known as type-1 and type-2 CRF receptors. The purpose of this review is to highlight recent advances in the interactions of CRF receptors with other GPCRs and non-GPCR proteins and their associated functional consequences. A better understanding of these interactions may generate new pharmacological alternatives for the treatment of addiction and stress-related disorders.
Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.
Paula G
PG
Slater
Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.
Hector E
HE
Yarur
Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile kgysling@bio.puc.cl.
Katia
K
Gysling
D000818:Animals; D006801:Humans; D008954:Models, Biological; D011485:Protein Binding; D055503:Protein Multimerization; D018019:Receptors, Corticotropin-Releasing Hormone / Q000378:metabolism*
D018019:Receptors, Corticotropin-Releasing Hormone