Comment on "Principles of connectivity among morphologically defined cell types in adult neocortex".
Jiang et al (Research Article, 27 November 2015, aac9462) describe detailed experiments that substantially add to the knowledge of cortical microcircuitry and are unique in the number of connections reported and the quality of interneuron reconstruction. The work appeals to experts and laypersons because of the notion that it unveils new principles and provides a complete description of cortical circuits. We provide a counterbalance to the authors' claims to give those less familiar with the minutiae of cortical circuits a better sense of the contributions and the limitations of this study.
159C Mellon Institute, Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA.
Alison
L
Barth
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Andreas
A
Burkhalter
Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. jochen.staiger@med.uni-goettingen.de rudyb01@med.nyu.edu callaway@salk.edu.
Edward M
EM
Callaway
Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA.
Barry W
BW
Connors
Neuroscience Paris Seine (NPS), Cortical Network and Neurovascular Coupling (CNNC), CNRS UMR 8246, Inserm U 1130, UPMC UM 119, Université Pierre et Marie Curie, 9 Quai Saint Bernard, 75005 Paris, France.
Bruno
B
Cauli
Laboratorio Cajal de Circuitos Corticales, Centro de Tecnologia Biomedica, Universidad Politecnica de Madrid, Campus Montegancedo S/N, Pozuelo de Alarcon, 28223 Madrid, Spain. Instituto Cajal (CSIC), Avenida Doctor Arce 37, 28002 Madrid, Spain.
Javier
J
DeFelipe
Institut für Neurowissenschaften und Medizin (INM-2), Forschungszentrum Jülich, 52425 Jülich, Germany.
Dirk
D
Feldmeyer
Department of Cellular and Network Neurobiology, Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1450 Budapest, POB 67, Hungary.
Tamas
T
Freund
Division of Cerebral Circuitry, National Institute for Physiological Sciences, 5-1 Myodaiji-Higashiyama, Okazaki, Aichi 444-8787, Japan.
Yasuo
Y
Kawaguchi
University of Debrecen, Department of Anatomy, Histology, Embryology, Laboratory for Cortical Systems Neuroscience, Nagyerdei krt. 98, 4012 Debrecen, Hungary.
Zoltan
Z
Kisvarday
Division of Cerebral Circuitry, National Institute for Physiological Sciences, 5-1 Myodaiji-Higashiyama, Okazaki, Aichi 444-8787, Japan.
Yoshiyuki
Y
Kubota
Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, 35 Convent Drive MSC3715, Bethesda, MD 20892, USA.
Chris
C
McBain
Max Planck Institute for Biological Cybernetics, Computational Neuroanatomy Group, D-72076 Tubingen, Germany.
Marcel
M
Oberlaender
Neuroscience Paris Seine, Univerisité Pierre et Marie Curie (UPMC) Paris VI, 7-9 Quai Saint Bernard, 75005 Paris, France.
Jean
J
Rossier
Neuroscience Institute, Department of Anesthesiology, Perioperative Care, and Pain Medicine, New York University School of Medicine, Smilow Research Center, 522 First Avenue, New York, NY 10016, USA. jochen.staiger@med.uni-goettingen.de rudyb01@med.nyu.edu callaway@salk.edu.
Bernardo
B
Rudy
University Medicine Goettingen, Center for Anatomy, Institute for Neuroanatomy, Kreuzbergring 36, D-37075 Goettingen, Germany. jochen.staiger@med.uni-goettingen.de rudyb01@med.nyu.edu callaway@salk.edu.
Jochen F
JF
Staiger
Medical Research Council Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3TH, UK.
Peter
P
Somogyi
Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép Fasor 52, Szeged, H-6726 Hungary.
Gabor
G
Tamas
Kavli institute of Brain Science, Columbia University, Department of Biological Sciences, West 120 Street, New York, NY 10027, USA.
Rafael
R
Yuste
D006801:Humans; D007395:Interneurons; D019579:Neocortex