Vitamin D Receptor (VDR) Polymorphisms in Pediatric Patients Presenting With Hodgkin's Lymphoma.
Vitamin D receptor (VDR) polymorphisms are found more commonly in some tumor types than in healthy individuals, suggesting that some polymorphisms (Cdx2, Fok1, Bsm1, Apa1, Taq1) contribute to tumor development. There is no previous report on VDR polymorphism in Hodgkin's lymphoma (HL) patients. VDR polymorphism patterns in 95 pediatric HL cases with 100 healthy controls were compared. No statistically significant difference was found between the patient group and control group in terms of Cdx2, Fok1, Bsm1, Apa1, and Taq1 polymorphisms (P>0.5). Our findings suggest that VDR polymorphisms may not play a role in HL development.
Dr Sami Ulus Maternity and Children ResearchTraining Hospital, Ankara, Turkey.
Sibel A
SA
Tekgündüz
Şule
Ş
Yeşil
Ayşe C
AC
Ören
Hikmet G
HG
Tanyildiz
Mehmet O
MO
Çandir
Ceyhun
C
Bozkurt
Gürses
G
Şahin
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006689:Hodgkin Disease / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D018167:Receptors, Calcitriol / Q000235:genetics*; D018401:Sample Size; D013154:Spleen / Q000473:pathology; D014421:Turkey
D018167:Receptors, Calcitriol