Relationship between interleukin-1β and depressive disorder after acute coronary syndrome.
This study was aimed to investigate the effect of serum interleukin (IL)-1β in the depression trajectory after acute coronary syndrome (ACS) considering two IL-1β polymorphisms: -511C/T or +3953C/T. A total of 969 patients were evaluated within 2weeks after ACS and of these, 711 were followed-up 1year later. Depressive disorders were evaluated at baseline and 1year after ACS, using the Mini-International Neuropsychiatric Interview. Serum IL-1β levels and IL-1β genotypes were investigated at baseline. Covariates on socio-demographic and clinical characteristics including depressive symptoms, cardiovascular risk factors, and current cardiac status were assessed. Depression during the acute ACS was significantly associated with the IL-1β levels and the -511T allele. The interaction of the IL-1β level with depression at baseline in the presence of the -511T allele was also significant. No associations were found with depression during the chronic ACS. For the +3953C/T genotype, there was no association with depression in either the acute or chronic phase. The IL-1β level and -511C/T genotype, separately or interactively, could be a biomarker for depressive disorder in the acute phase of ACS. Focused interventions for those with higher IL-1β level and -511T allele might reduce the risk of depressive disorder.
Departments of Psychiatry, Chonnam National University Medical School, Republic of Korea.
Hee-Ju
HJ
Kang
Departments of Psychiatry, Chonnam National University Medical School, Republic of Korea.
Kyung-Yeol
KY
Bae
Departments of Psychiatry, Chonnam National University Medical School, Republic of Korea.
Sung-Wan
SW
Kim
Departments of Psychiatry, Chonnam National University Medical School, Republic of Korea.
Il-Seon
IS
Shin
Departments of Caridology, Chonnam National University Medical School, Republic of Korea.
Young Joon
YJ
Hong
Departments of Caridology, Chonnam National University Medical School, Republic of Korea.
Youngkeun
Y
Ahn
Departments of Caridology, Chonnam National University Medical School, Republic of Korea.
Myung Ho
MH
Jeong
Departments of Psychiatry, Chonnam National University Medical School, Republic of Korea.
Jin-Sang
JS
Yoon
Departments of Psychiatry, Chonnam National University Medical School, Republic of Korea. Electronic address: jmkim@chonnam.ac.kr.
Jae-Min
JM
Kim
D054058:Acute Coronary Syndrome / Q000150:complications* / Q000235:genetics*; D016009:Chi-Square Distribution; D003866:Depressive Disorder / Q000097:blood / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood* / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
D053583:Interleukin-1beta
Acute coronary syndrome; Depression; Gene association study; Interaction; Interleukin-1β