Modulation of the Inflammasome Signaling Pathway by Enteropathogenic and Enterohemorrhagic Escherichia coli.
Innate immunity is an essential component in the protection of a host against pathogens. Enteropathogenic and enterohemorrhagic Escherichia coli (EPEC and EHEC, respectively) are known to modulate the innate immune responses of infected cells. The interference is dependent on their type III secretion system (T3SS) and T3SS-dependent effector proteins. Furthermore, these cytosolically injected effectors have been demonstrated to engage multiple immune signaling pathways, including the IFN/STAT, MAPK, NF-κB, and inflammasome pathways. In this review, recent work describing the interaction between EPEC/EHEC and the inflammasome pathway will be discussed.
Department of Biomedical Informatics, Graduate School of Medicine, Osaka University Osaka, Japan.
Hilo
H
Yen
Department of Biomedical Informatics, Graduate School of Medicine, Osaka University Osaka, Japan.
Masaki
M
Karino
Department of Biomedical Informatics, Graduate School of Medicine, Osaka University Osaka, Japan.
Toru
T
Tobe
D000818:Animals; D054324:Enterohemorrhagic Escherichia coli / Q000276:immunology / Q000472:pathogenicity*; D054308:Enteropathogenic Escherichia coli / Q000276:immunology / Q000472:pathogenicity*; D029968:Escherichia coli Proteins / Q000378:metabolism; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D058847:Inflammasomes / Q000037:antagonists & inhibitors*; D015398:Signal Transduction; D000069296:Type III Secretion Systems / Q000378:metabolism; D037521:Virulence Factors / Q000378:metabolism*
D029968:Escherichia coli Proteins; D058847:Inflammasomes; D000069296:Type III Secretion Systems; D037521:Virulence Factors
effectors; enteropathogenic Escherichia coli; enterophenorrhagic Escherichia coli; inflammasome; type 3 secretion system