Two cases of malignant lymphoma with reactivation of resolved hepatitis B virus infection after bendamustine hydrochloride monotherapy.
A 63-year-old female and a 63-year-old male with resolved HBV infection suffered a relapse of malignant lymphoma. After bendamustine hydrochloride monotherapy, HBV reactivation occurred. Entecavir treatment was commenced immediately, with tests for HBV DNA negative without development of hepatitis. Regular monitoring of HBV DNA based on the guidelines from the Japan Society of Hepatology was useful.
Department of Internal Medicine, Kitakyushu Municipal Medical Center.
Yoshiki
Y
Hiraki
Akira
A
Kawano
Hirohisa
H
Shigematsu
Koichiro
K
Miki
Hideyuki
H
Nomura
Shinji
S
Shimoda
D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D000069461:Bendamustine Hydrochloride / Q000627:therapeutic use*; D005260:Female; D006509:Hepatitis B / Q000821:virology*; D006515:Hepatitis B virus / Q000502:physiology*; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D014775:Virus Activation
D018906:Antineoplastic Agents, Alkylating; D000069461:Bendamustine Hydrochloride