Recurrent Hypoglycaemia due to Insulin Autoimmune Disease (Hirata Disease) Associated with Monoclonal Gammopathy of Unknown Significance.
Hirata disease is a rare disease characterised by recurrent episodes of hypoglycaemia due to anti-insulin antibody. In most of these cases causative agents were sulfhydryl containing compounds like Penicillamine, Glutathione, and Methimazole. The presentation of disease closely mimics insulinoma. We report 52 years female patient presenting with recurrent episodes of hypoglycaemia due to anti-insulin antibody. On evaluation, underlying cause of antibody was found to be monoclonal gammopathy of unknown significance (MGUS).
Resident.
Jayant
J
Gite
Resident.
Rohit
R
Shrivastav
Resident.
Nikhil
N
Bhasin
Senior Resident.
Puneet
P
Mashru
Associate Professor.
Manish
M
Itolikar
Professor and Head of Unit at Department of Medicine, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra.
Milind Y
MY
Nadkar
D001327:Autoimmune Diseases / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology*; D007330:Insulin Antibodies / Q000097:blood; D008875:Middle Aged; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000175:diagnosis*; D012008:Recurrence
D007330:Insulin Antibodies