Techniques and Approaches to Genetic Analyses in Nephrological Disorders.
Inherited renal disease is a leading cause of morbidity and mortality in pediatric nephrology. High throughput advancements in genomics have led to greater understanding of the biologic underpinnings of these diseases. However, the underlying genetic changes explain only part of the molecular biology that contributes to disease manifestation and progression. Other omics technologies will provide a more complete picture of these cellular processes. This review discusses these omics technologies in the context of pediatric renal disease.
Center for Pediatric Genomic Medicine, Kansas City, Missouri, United States; Division of Nephrology, Children's Mercy Hospital, Kansas City, Missouri, United States; Department of Pediatrics, University of Missouri-Kansas City, Kansas City, Missouri, United States.
Laurel K
LK
Willig
epigenomics; genomics; metabolomics; nephrology; next generation sequencing; proteomics; transcriptomics