Gold Nanorods as Drug Delivery Vehicles for Rifampicin Greatly Improve the Efficacy of Combating Mycobacterium tuberculosis with Good Biocompatibility with the Host Cells.
TB remains a challenging disease to control worldwide. Nanoparticles have been used as drug carriers to deliver high concentrations of antibiotics directly to the site of infection, reducing the duration of treatment along with any side effects of off-target toxicities after systemic exposure to the antibiotics. Herein we have developed a drug delivery platform where gold nanorods (AuNRs) are conjugated to rifampicin (RF), which is released after uptake into macrophage cells (RAW264.7). Due to the nature of the macrophage cells, the nanoparticles are actively internalized into macrophages and release RF after uptake, under the safety frame of the host cells (macrophage). AuNRs without RF conjugation exhibit obvious antimicrobial activity. Therefore, AuNRs could be a promising antimycobacterial agent and an effective delivery vehicle for the antituberculosis drug Rifampicin for use in tuberculosis therapy.
School of Chemistry and Biochemistry, Georgia Institute of Technology , Atlanta, Georgia 30332-0400, United States.|Animal Health Research Institute (AHRI) , Department of Bacteriology and Immunology, Dokki, Giza, Egypt.|Department of Veterinary Medicine, Cairo University , Giza, Cairo, Egypt.
Hala R
HR
Ali
School of Chemistry and Biochemistry, Georgia Institute of Technology , Atlanta, Georgia 30332-0400, United States.
Moustafa R K
MR
Ali
School of Chemistry and Biochemistry, Georgia Institute of Technology , Atlanta, Georgia 30332-0400, United States.
Yue
Y
Wu
Department of Veterinary Medicine, Cairo University , Giza, Cairo, Egypt.
Salah A
SA
Selim
Department of Pathobiological Sciences, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.
Hazem F M
HF
Abdelaal
Veterinary Serum and Vaccine Research Institute , Bacterial Diagnostics Research Department (Tuberculosis), Abbasia, Cairo, Egypt.
Essam A
EA
Nasr
School of Chemistry and Biochemistry, Georgia Institute of Technology , Atlanta, Georgia 30332-0400, United States.|Adjunct Professor, School of Chemistry, King Abdul Aziz University , Jeddah, Saudi Arabia.
Mostafa A
MA
El-Sayed
D000818:Animals; D000995:Antitubercular Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002460:Cell Line; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation; D006046:Gold / Q000737:chemistry; D054884:Host-Pathogen Interactions / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects / Q000382:microbiology; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000472:pathogenicity; D043942:Nanotubes / Q000737:chemistry*; D012293:Rifampin / Q000008:administration & dosage*; D014376:Tuberculosis / Q000188:drug therapy / Q000382:microbiology
D000995:Antitubercular Agents; D006046:Gold; D012293:Rifampin