IFR4/MUM1-positive lymphoma in Waldeyer ring with co-expression of CD5 and CD10.
IRF4/MUM1-positive lymphoma is a new subgroup of germinal center-derived B-cell lymphoma, predominantly involving the Waldeyer ring (WR) in children. CD5 expression is rare in these lymphomas. We report a 7-year-old Chinese male with B-cell lymphoma. Evaluation of his specimen by morphology, immunohistochemistry, and FISH analysis demonstrated IRF4/MUM1-positive lymphoma with strong and extensive CD5 and CD10 positivity. Despite the lack of t(14;18)(q32;q21) rearrangement, BCL2 protein was expressed. Our report highlights the clinicopathologic features of IFR4/MUM1-positive lymphoma in WR with co-expression of CD5 and CD10, and thereby provides insight into this newly recognized disease entity.
Department of Pathology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Lei
L
Chen
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
Lika'a Fasih Y
LF
Al-Kzayer
Department of Pediatric Hematology/Oncology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Tingting
T
Liu
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
Norimoto
N
Kobayashi
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
Yozo
Y
Nakazawa
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
Kenichi
K
Koike
D018956:CD5 Antigens / Q000235:genetics / Q000378:metabolism*; D002648:Child; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D050835:Interferon Regulatory Factors / Q000235:genetics / Q000378:metabolism*; D008223:Lymphoma / Q000145:classification / Q000378:metabolism / Q000473:pathology*; D008297:Male; D015260:Neprilysin / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis; D014067:Tonsillar Neoplasms / Q000378:metabolism / Q000473:pathology*; D000099218:Interferon Regulatory Factor-4
D018956:CD5 Antigens; D050835:Interferon Regulatory Factors; D015260:Neprilysin; D000099218:Interferon Regulatory Factor-4
CD5; IRF4/MUM1-positive lymphoma; Waldeyer ring; pediatric follicular lymphoma