Ungual hyalohyphomycosis caused by Fusarium proliferatum in an immunocompetent patient.
The patient was a 73-year-old healthy female farmer who had been treated with terbinafine for 25.5 months by a primary physician. She exhibited a discoloration and thickening of the right big toenail. She had no concomitant paronychia. Direct microscopy revealed chlamydoconidia and hyphae, and periodic acid-Schiff stained nail specimen showed septate hyphae. On the basis of these morphological features and gene analysis, the final diagnosis was ungual hyalohyphomycosis caused by Fusarium proliferatum. Topical application of 10% efinaconazole solution cured the disease in 10 months.
Noguchi Dermatology Clinic, Kumamoto, Japan.|Ochanomizu Institute for Medical Mycology and Allergology, Tokyo, Japan.
Hiromitsu
H
Noguchi
Ochanomizu Institute for Medical Mycology and Allergology, Tokyo, Japan.
Masataro
M
Hiruma
Ochanomizu Institute for Medical Mycology and Allergology, Tokyo, Japan.
Tadahiko
T
Matsumoto
Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa, Japan.
Rui
R
Kano
Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Hironobu
H
Ihn
D000287:Administration, Topical; D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005533:Foot Dermatoses / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D060585:Fusariosis / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D005670:Fusarium / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D025301:Hyphae / Q000302:isolation & purification; D009281:Naphthalenes / Q000008:administration & dosage / Q000627:therapeutic use*; D014009:Onychomycosis / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D000077291:Terbinafine; D014230:Triazoles / Q000008:administration & dosage / Q000627:therapeutic use*
D000935:Antifungal Agents; D009281:Naphthalenes; D014230:Triazoles; D000077291:Terbinafine; C431707:efinaconazole

Fusarium proliferatum
; efinaconazole; hyalohyphomycosis; non-dermatophyte; onychomycosis