Long-Term Follow-Up of Outcomes With F-18-Fluorodeoxyglucose Positron Emission Tomography Imaging-Assisted Management of Patients With Severe Left Ventricular Dysfunction Secondary to Coronary Disease.
BACKGROUND
Whether viability imaging can impact long-term patient outcomes is uncertain. The PARR-2 study (Positron Emission Tomography and Recovery Following Revascularization) showed a nonsignificant trend toward improved outcomes at 1 year using an F-18-fluorodeoxyglucose positron emission tomography (PET)-assisted strategy in patients with suspected ischemic cardiomyopathy. When patients adhered to F-18-fluorodeoxyglucose PET recommendations, outcome benefit was observed. Long-term outcomes of viability imaging-assisted management have not previously been evaluated in a randomized controlled trial.


RESULTS
PARR-2 randomized patients with severe left ventricular dysfunction and suspected CAD being considered for revascularization or transplantation to standard care (n= 195) versus PET-assisted management (n=197) at sites participating in long-term follow-up. The predefined primary outcome was time to composite event (cardiac death, myocardial infarction, or cardiac hospitalization). After 5 years, 105 (53%) patients in the PET arm and 111 (57%) in the standard care arm experienced the composite event (hazard ratio for time to composite event =0.82 [95% confidence interval 0.62-1.07]; P=0.15). When only patients who adhered to PET recommendations were included, the hazard ratio for the time to primary outcome was 0.73 (95% confidence interval 0.54-0.99; P=0.042).


CONCLUSIONS
After a 5-year follow-up in patients with left ventricular dysfunction and suspected CAD, overall, PET-assisted management did not significantly reduce cardiac events compared with standard care. However, significant benefits were observed when there was adherence to PET recommendations. PET viability imaging may be best applied when there is likely to be adherence to imaging-based recommendations.


BACKGROUND
URL: http://www.clinicaltrials.gov. Unique identifier: NCT00385242.
From the Molecular Function and Imaging Program, The National Cardiac PET Centre, Division of Cardiology, Department of Medicine and the Division of Cardiac Surgery, Department of Surgery and the Cardiac Research Methods Centre, University of Ottawa Heart Institute and University of Ottawa, Canada (B.M., T.S., R.A.D., J.B., A.G., S.P.L., R.A.D., H.H., L.D., P.H., R.M., T.D.R., B.J.C., L.M., J.N.D., L.G., G.A.W., R.S.B.B.); Department of Medicine, Division of General Internal Medicine, University of Washington-Harborview Center for Prehospital Emergency Care, Seattle, (G.N.); Department of Medicine, Divisions of Cardiology, University Health Network and St Michael's Hospital, University of Toronto, Canada (H.R., M.F.); ES Garnett Memorial PET Center, Department of Nuclear Medicine, Hamilton Health Sciences, Canada (K.G.); Department of Medicine, Division of Cardiology, Montréal Heart Institute, Canada (N.R.); Department of Medicine, Division of Cardiology, London Health Sciences Centre, Canada (D.H.); and Department of Molecular Oncology, University of British Columbia, Vancouver, Canada; and Department of Nuclear Medicine and Radiobiology, Division of Nuclear Medicine, Centre hospitalier universitaire de Sherbrooke, Canada (F.B.).
Brian
B
Mc Ardle
From the Molecular Function and Imaging Program, The National Cardiac PET Centre, Division of Cardiology, Department of Medicine and the Division of Cardiac Surgery, Department of Surgery and the Cardiac Research Methods Centre, University of Ottawa Heart Institute and University of Ottawa, Canada (B.M., T.S., R.A.D., J.B., A.G., S.P.L., R.A.D., H.H., L.D., P.H., R.M., T.D.R., B.J.C., L.M., J.N.D., L.G., G.A.W., R.S.B.B.); Department of Medicine, Division of General Internal Medicine, University of Washington-Harborview Center for Prehospital Emergency Care, Seattle, (G.N.); Department of Medicine, Divisions of Cardiology, University Health Network and St Michael's Hospital, University of Toronto, Canada (H.R., M.F.); ES Garnett Memorial PET Center, Department of Nuclear Medicine, Hamilton Health Sciences, Canada (K.G.); Department of Medicine, Division of Cardiology, Montréal Heart Institute, Canada (N.R.); Department of Medicine, Division of Cardiology, London Health Sciences Centre, Canada (D.H.); and Department of Molecular Oncology, University of British Columbia, Vancouver, Canada; and Department of Nuclear Medicine and Radiobiology, Division of Nuclear Medicine, Centre hospitalier universitaire de Sherbrooke, Canada (F.B.).
Tushar
T
Shukla
From the Molecular Function and Imaging Program, The National Cardiac PET Centre, Division of Cardiology, Department of Medicine and the Division of Cardiac Surgery, Department of Surgery and the Cardiac Research Methods Centre, University of Ottawa Heart Institute and University of Ottawa, Canada (B.M., T.S., R.A.D., J.B., A.G., S.P.L., R.A.D., H.H., L.D., P.H., R.M., T.D.R., B.J.C., L.M., J.N.D., L.G., G.A.W., R.S.B.B.); Department of Medicine, Division of General Internal Medicine, University of Washington-Harborview Center for Prehospital Emergency Care, Seattle, (G.N.); Department of Medicine, Divisions of Cardiology, University Health Network and St Michael's Hospital, University of Toronto, Canada (H.R., M.F.); ES Garnett Memorial PET Center, Department of Nuclear Medicine, Hamilton Health Sciences, Canada (K.G.); Department of Medicine, Division of Cardiology, Montréal Heart Institute, Canada (N.R.); Department of Medicine, Division of Cardiology, London Health Sciences Centre, Canada (D.H.); and Department of Molecular Oncology, University of British Columbia, Vancouver, Canada; and Department of Nuclear Medicine and Radiobiology, Division of Nuclear Medicine, Centre hospitalier universitaire de Sherbrooke, Canada (F.B.).
Graham
G
Nichol
From the Molecular Function and Imaging Program, The National Cardiac PET Centre, Division of Cardiology, Department of Medicine and the Division of Cardiac Surgery, Department of Surgery and the Cardiac Research Methods Centre, University of Ottawa Heart Institute and University of Ottawa, Canada (B.M., T.S., R.A.D., J.B., A.G., S.P.L., R.A.D., H.H., L.D., P.H., R.M., T.D.R., B.J.C., L.M., J.N.D., L.G., G.A.W., R.S.B.B.); Department of Medicine, Division of General Internal Medicine, University of Washington-Harborview Center for Prehospital Emergency Care, Seattle, (G.N.); Department of Medicine, Divisions of Cardiology, University Health Network and St Michael's Hospital, University of Toronto, Canada (H.R., M.F.); ES Garnett Memorial PET Center, Department of Nuclear Medicine, Hamilton Health Sciences, Canada (K.G.); Department of Medicine, Division of Cardiology, Montréal Heart Institute, Canada (N.R.); Department of Medicine, Division of Cardiology, London Health Sciences Centre, Canada (D.H.); and Department of Molecular Oncology, University of British Columbia, Vancouver, Canada; and Department of Nuclear Medicine and Radiobiology, Division of Nuclear Medicine, Centre hospitalier universitaire de Sherbrooke, Canada (F.B.).
Robert A
RA
deKemp
From the Molecular Function and Imaging Program, The National Cardiac PET Centre, Division of Cardiology, Department of Medicine and the Division of Cardiac Surgery, Department of Surgery and the Cardiac Research Methods Centre, University of Ottawa Heart Institute and University of Ottawa, Canada (B.M., T.S., R.A.D., J.B., A.G., S.P.L., R.A.D., H.H., L.D., P.H., R.M., T.D.R., B.J.C., L.M., J.N.D., L.G., G.A.W., R.S.B.B.); Department of Medicine, Division of General Internal Medicine, University of Washington-Harborview Center for Prehospital Emergency Care, Seattle, (G.N.); Department of Medicine, Divisions of Cardiology, University Health Network and St Michael's Hospital, University of Toronto, Canada (H.R., M.F.); ES Garnett Memorial PET Center, Department of Nuclear Medicine, Hamilton Health Sciences, Canada (K.G.); Department of Medicine, Division of Cardiology, Montréal Heart Institute, Canada (N.R.); Department of Medicine, Division of Cardiology, London Health Sciences Centre, Canada (D.H.); and Department of Molecular Oncology, University of British Columbia, Vancouver, Canada; and Department of Nuclear Medicine and Radiobiology, Division of Nuclear Medicine, Centre hospitalier universitaire de Sherbrooke, Canada (F.B.).
Jordan
J
Bernick
From the Molecular Function and Imaging Program, The National Cardiac PET Centre, Division of Cardiology, Department of Medicine and the Division of Cardiac Surgery, Department of Surgery and the Cardiac Research Methods Centre, University of Ottawa Heart Institute and University of Ottawa, Canada (B.M., T.S., R.A.D., J.B., A.G., S.P.L., R.A.D., H.H., L.D., P.H., R.M., T.D.R., B.J.C., L.M., J.N.D., L.G., G.A.W., R.S.B.B.); Department of Medicine, Division of General Internal Medicine, University of Washington-Harborview Center for Prehospital Emergency Care, Seattle, (G.N.); Department of Medicine, Divisions of Cardiology, University Health Network and St Michael's Hospital, University of Toronto, Canada (H.R., M.F.); ES Garnett Memorial PET Center, Department of Nuclear Medicine, Hamilton Health Sciences, Canada (K.G.); Department of Medicine, Division of Cardiology, Montréal Heart Institute, Canada (N.R.); Department of Medicine, Division of Cardiology, London Health Sciences Centre, Canada (D.H.); and Department of Molecular Oncology, University of British Columbia, Vancouver, Canada; and Department of Nuclear Medicine and Radiobiology, Division of Nuclear Medicine, Centre hospitalier universitaire de Sherbrooke, Canada (F.B.).
Ann
A
Guo
From the Molecular Function and Imaging Program, The National Cardiac PET Centre, Division of Cardiology, Department of Medicine and the Division of Cardiac Surgery, Department of Surgery and the Cardiac Research Methods Centre, University of Ottawa Heart Institute and University of Ottawa, Canada (B.M., T.S., R.A.D., J.B., A.G., S.P.L., R.A.D., H.H., L.D., P.H., R.M., T.D.R., B.J.C., L.M., J.N.D., L.G., G.A.W., R.S.B.B.); Department of Medicine, Division of General Internal Medicine, University of Washington-Harborview Center for Prehospital Emergency Care, Seattle, (G.N.); Department of Medicine, Divisions of Cardiology, University Health Network and St Michael's Hospital, University of Toronto, Canada (H.R., M.F.); ES Garnett Memorial PET Center, Department of Nuclear Medicine, Hamilton Health Sciences, Canada (K.G.); Department of Medicine, Division of Cardiology, Montréal Heart Institute, Canada (N.R.); Department of Medicine, Division of Cardiology, London Health Sciences Centre, Canada (D.H.); and Department of Molecular Oncology, University of British Columbia, Vancouver, Canada; and Department of Nuclear Medicine and Radiobiology, Division of Nuclear Medicine, Centre hospitalier universitaire de Sherbrooke, Canada (F.B.).
Siok Ping
SP
Lim
From the Molecular Function and Imaging Program, The National Cardiac PET Centre, Division of Cardiology, Department of Medicine and the Division of Cardiac Surgery, Department of Surgery and the Cardiac Research Methods Centre, University of Ottawa Heart Institute and University of Ottawa, Canada (B.M., T.S., R.A.D., J.B., A.G., S.P.L., R.A.D., H.H., L.D., P.H., R.M., T.D.R., B.J.C., L.M., J.N.D., L.G., G.A.W., R.S.B.B.); Department of Medicine, Division of General Internal Medicine, University of Washington-Harborview Center for Prehospital Emergency Care, Seattle, (G.N.); Department of Medicine, Divisions of Cardiology, University Health Network and St Michael's Hospital, University of Toronto, Canada (H.R., M.F.); ES Garnett Memorial PET Center, Department of Nuclear Medicine, Hamilton Health Sciences, Canada (K.G.); Department of Medicine, Division of Cardiology, Montréal Heart Institute, Canada (N.R.); Department of Medicine, Division of Cardiology, London Health Sciences Centre, Canada (D.H.); and Department of Molecular Oncology, University of British Columbia, Vancouver, Canada; and Department of Nuclear Medicine and Radiobiology, Division of Nuclear Medicine, Centre hospitalier universitaire de Sherbrooke, Canada (F.B.).
Ross A
RA
Davies
From the Molecular Function and Imaging Program, The National Cardiac PET Centre, Division of Cardiology, Department of Medicine and the Division of Cardiac Surgery, Department of Surgery and the Cardiac Research Methods Centre, University of Ottawa Heart Institute and University of Ottawa, Canada (B.M., T.S., R.A.D., J.B., A.G., S.P.L., R.A.D., H.H., L.D., P.H., R.M., T.D.R., B.J.C., L.M., J.N.D., L.G., G.A.W., R.S.B.B.); Department of Medicine, Division of General Internal Medicine, University of Washington-Harborview Center for Prehospital Emergency Care, Seattle, (G.N.); Department of Medicine, Divisions of Cardiology, University Health Network and St Michael's Hospital, University of Toronto, Canada (H.R., M.F.); ES Garnett Memorial PET Center, Department of Nuclear Medicine, Hamilton Health Sciences, Canada (K.G.); Department of Medicine, Division of Cardiology, Montréal Heart Institute, Canada (N.R.); Department of Medicine, Division of Cardiology, London Health Sciences Centre, Canada (D.H.); and Department of Molecular Oncology, University of British Columbia, Vancouver, Canada; and Department of Nuclear Medicine and Radiobiology, Division of Nuclear Medicine, Centre hospitalier universitaire de Sherbrooke, Canada (F.B.).
Haissam
H
Haddad
From the Molecular Function and Imaging Program, The National Cardiac PET Centre, Division of Cardiology, Department of Medicine and the Division of Cardiac Surgery, Department of Surgery and the Cardiac Research Methods Centre, University of Ottawa Heart Institute and University of Ottawa, Canada (B.M., T.S., R.A.D., J.B., A.G., S.P.L., R.A.D., H.H., L.D., P.H., R.M., T.D.R., B.J.C., L.M., J.N.D., L.G., G.A.W., R.S.B.B.); Department of Medicine, Division of General Internal Medicine, University of Washington-Harborview Center for Prehospital Emergency Care, Seattle, (G.N.); Department of Medicine, Divisions of Cardiology, University Health Network and St Michael's Hospital, University of Toronto, Canada (H.R., M.F.); ES Garnett Memorial PET Center, Department of Nuclear Medicine, Hamilton Health Sciences, Canada (K.G.); Department of Medicine, Division of Cardiology, Montréal Heart Institute, Canada (N.R.); Department of Medicine, Division of Cardiology, London Health Sciences Centre, Canada (D.H.); and Department of Molecular Oncology, University of British Columbia, Vancouver, Canada; and Department of Nuclear Medicine and Radiobiology, Division of Nuclear Medicine, Centre hospitalier universitaire de Sherbrooke, Canada (F.B.).
Lloyd
L
Duchesne
From the Molecular Function and Imaging Program, The National Cardiac PET Centre, Division of Cardiology, Department of Medicine and the Division of Cardiac Surgery, Department of Surgery and the Cardiac Research Methods Centre, University of Ottawa Heart Institute and University of Ottawa, Canada (B.M., T.S., R.A.D., J.B., A.G., S.P.L., R.A.D., H.H., L.D., P.H., R.M., T.D.R., B.J.C., L.M., J.N.D., L.G., G.A.W., R.S.B.B.); Department of Medicine, Division of General Internal Medicine, University of Washington-Harborview Center for Prehospital Emergency Care, Seattle, (G.N.); Department of Medicine, Divisions of Cardiology, University Health Network and St Michael's Hospital, University of Toronto, Canada (H.R., M.F.); ES Garnett Memorial PET Center, Department of Nuclear Medicine, Hamilton Health Sciences, Canada (K.G.); Department of Medicine, Division of Cardiology, Montréal Heart Institute, Canada (N.R.); Department of Medicine, Division of Cardiology, London Health Sciences Centre, Canada (D.H.); and Department of Molecular Oncology, University of British Columbia, Vancouver, Canada; and Department of Nuclear Medicine and Radiobiology, Division of Nuclear Medicine, Centre hospitalier universitaire de Sherbrooke, Canada (F.B.).
Paul
P
Hendry
From the Molecular Function and Imaging Program, The National Cardiac PET Centre, Division of Cardiology, Department of Medicine and the Division of Cardiac Surgery, Department of Surgery and the Cardiac Research Methods Centre, University of Ottawa Heart Institute and University of Ottawa, Canada (B.M., T.S., R.A.D., J.B., A.G., S.P.L., R.A.D., H.H., L.D., P.H., R.M., T.D.R., B.J.C., L.M., J.N.D., L.G., G.A.W., R.S.B.B.); Department of Medicine, Division of General Internal Medicine, University of Washington-Harborview Center for Prehospital Emergency Care, Seattle, (G.N.); Department of Medicine, Divisions of Cardiology, University Health Network and St Michael's Hospital, University of Toronto, Canada (H.R., M.F.); ES Garnett Memorial PET Center, Department of Nuclear Medicine, Hamilton Health Sciences, Canada (K.G.); Department of Medicine, Division of Cardiology, Montréal Heart Institute, Canada (N.R.); Department of Medicine, Division of Cardiology, London Health Sciences Centre, Canada (D.H.); and Department of Molecular Oncology, University of British Columbia, Vancouver, Canada; and Department of Nuclear Medicine and Radiobiology, Division of Nuclear Medicine, Centre hospitalier universitaire de Sherbrooke, Canada (F.B.).
Roy
R
Masters
From the Molecular Function and Imaging Program, The National Cardiac PET Centre, Division of Cardiology, Department of Medicine and the Division of Cardiac Surgery, Department of Surgery and the Cardiac Research Methods Centre, University of Ottawa Heart Institute and University of Ottawa, Canada (B.M., T.S., R.A.D., J.B., A.G., S.P.L., R.A.D., H.H., L.D., P.H., R.M., T.D.R., B.J.C., L.M., J.N.D., L.G., G.A.W., R.S.B.B.); Department of Medicine, Division of General Internal Medicine, University of Washington-Harborview Center for Prehospital Emergency Care, Seattle, (G.N.); Department of Medicine, Divisions of Cardiology, University Health Network and St Michael's Hospital, University of Toronto, Canada (H.R., M.F.); ES Garnett Memorial PET Center, Department of Nuclear Medicine, Hamilton Health Sciences, Canada (K.G.); Department of Medicine, Division of Cardiology, Montréal Heart Institute, Canada (N.R.); Department of Medicine, Division of Cardiology, London Health Sciences Centre, Canada (D.H.); and Department of Molecular Oncology, University of British Columbia, Vancouver, Canada; and Department of Nuclear Medicine and Radiobiology, Division of Nuclear Medicine, Centre hospitalier universitaire de Sherbrooke, Canada (F.B.).
Heather
H
Ross
From the Molecular Function and Imaging Program, The National Cardiac PET Centre, Division of Cardiology, Department of Medicine and the Division of Cardiac Surgery, Department of Surgery and the Cardiac Research Methods Centre, University of Ottawa Heart Institute and University of Ottawa, Canada (B.M., T.S., R.A.D., J.B., A.G., S.P.L., R.A.D., H.H., L.D., P.H., R.M., T.D.R., B.J.C., L.M., J.N.D., L.G., G.A.W., R.S.B.B.); Department of Medicine, Division of General Internal Medicine, University of Washington-Harborview Center for Prehospital Emergency Care, Seattle, (G.N.); Department of Medicine, Divisions of Cardiology, University Health Network and St Michael's Hospital, University of Toronto, Canada (H.R., M.F.); ES Garnett Memorial PET Center, Department of Nuclear Medicine, Hamilton Health Sciences, Canada (K.G.); Department of Medicine, Division of Cardiology, Montréal Heart Institute, Canada (N.R.); Department of Medicine, Division of Cardiology, London Health Sciences Centre, Canada (D.H.); and Department of Molecular Oncology, University of British Columbia, Vancouver, Canada; and Department of Nuclear Medicine and Radiobiology, Division of Nuclear Medicine, Centre hospitalier universitaire de Sherbrooke, Canada (F.B.).
Michael
M
Freeman
From the Molecular Function and Imaging Program, The National Cardiac PET Centre, Division of Cardiology, Department of Medicine and the Division of Cardiac Surgery, Department of Surgery and the Cardiac Research Methods Centre, University of Ottawa Heart Institute and University of Ottawa, Canada (B.M., T.S., R.A.D., J.B., A.G., S.P.L., R.A.D., H.H., L.D., P.H., R.M., T.D.R., B.J.C., L.M., J.N.D., L.G., G.A.W., R.S.B.B.); Department of Medicine, Division of General Internal Medicine, University of Washington-Harborview Center for Prehospital Emergency Care, Seattle, (G.N.); Department of Medicine, Divisions of Cardiology, University Health Network and St Michael's Hospital, University of Toronto, Canada (H.R., M.F.); ES Garnett Memorial PET Center, Department of Nuclear Medicine, Hamilton Health Sciences, Canada (K.G.); Department of Medicine, Division of Cardiology, Montréal Heart Institute, Canada (N.R.); Department of Medicine, Division of Cardiology, London Health Sciences Centre, Canada (D.H.); and Department of Molecular Oncology, University of British Columbia, Vancouver, Canada; and Department of Nuclear Medicine and Radiobiology, Division of Nuclear Medicine, Centre hospitalier universitaire de Sherbrooke, Canada (F.B.).
Karen
K
Gulenchyn
From the Molecular Function and Imaging Program, The National Cardiac PET Centre, Division of Cardiology, Department of Medicine and the Division of Cardiac Surgery, Department of Surgery and the Cardiac Research Methods Centre, University of Ottawa Heart Institute and University of Ottawa, Canada (B.M., T.S., R.A.D., J.B., A.G., S.P.L., R.A.D., H.H., L.D., P.H., R.M., T.D.R., B.J.C., L.M., J.N.D., L.G., G.A.W., R.S.B.B.); Department of Medicine, Division of General Internal Medicine, University of Washington-Harborview Center for Prehospital Emergency Care, Seattle, (G.N.); Department of Medicine, Divisions of Cardiology, University Health Network and St Michael's Hospital, University of Toronto, Canada (H.R., M.F.); ES Garnett Memorial PET Center, Department of Nuclear Medicine, Hamilton Health Sciences, Canada (K.G.); Department of Medicine, Division of Cardiology, Montréal Heart Institute, Canada (N.R.); Department of Medicine, Division of Cardiology, London Health Sciences Centre, Canada (D.H.); and Department of Molecular Oncology, University of British Columbia, Vancouver, Canada; and Department of Nuclear Medicine and Radiobiology, Division of Nuclear Medicine, Centre hospitalier universitaire de Sherbrooke, Canada (F.B.).
Normand
N
Racine
From the Molecular Function and Imaging Program, The National Cardiac PET Centre, Division of Cardiology, Department of Medicine and the Division of Cardiac Surgery, Department of Surgery and the Cardiac Research Methods Centre, University of Ottawa Heart Institute and University of Ottawa, Canada (B.M., T.S., R.A.D., J.B., A.G., S.P.L., R.A.D., H.H., L.D., P.H., R.M., T.D.R., B.J.C., L.M., J.N.D., L.G., G.A.W., R.S.B.B.); Department of Medicine, Division of General Internal Medicine, University of Washington-Harborview Center for Prehospital Emergency Care, Seattle, (G.N.); Department of Medicine, Divisions of Cardiology, University Health Network and St Michael's Hospital, University of Toronto, Canada (H.R., M.F.); ES Garnett Memorial PET Center, Department of Nuclear Medicine, Hamilton Health Sciences, Canada (K.G.); Department of Medicine, Division of Cardiology, Montréal Heart Institute, Canada (N.R.); Department of Medicine, Division of Cardiology, London Health Sciences Centre, Canada (D.H.); and Department of Molecular Oncology, University of British Columbia, Vancouver, Canada; and Department of Nuclear Medicine and Radiobiology, Division of Nuclear Medicine, Centre hospitalier universitaire de Sherbrooke, Canada (F.B.).
Dennis
D
Humen
From the Molecular Function and Imaging Program, The National Cardiac PET Centre, Division of Cardiology, Department of Medicine and the Division of Cardiac Surgery, Department of Surgery and the Cardiac Research Methods Centre, University of Ottawa Heart Institute and University of Ottawa, Canada (B.M., T.S., R.A.D., J.B., A.G., S.P.L., R.A.D., H.H., L.D., P.H., R.M., T.D.R., B.J.C., L.M., J.N.D., L.G., G.A.W., R.S.B.B.); Department of Medicine, Division of General Internal Medicine, University of Washington-Harborview Center for Prehospital Emergency Care, Seattle, (G.N.); Department of Medicine, Divisions of Cardiology, University Health Network and St Michael's Hospital, University of Toronto, Canada (H.R., M.F.); ES Garnett Memorial PET Center, Department of Nuclear Medicine, Hamilton Health Sciences, Canada (K.G.); Department of Medicine, Division of Cardiology, Montréal Heart Institute, Canada (N.R.); Department of Medicine, Division of Cardiology, London Health Sciences Centre, Canada (D.H.); and Department of Molecular Oncology, University of British Columbia, Vancouver, Canada; and Department of Nuclear Medicine and Radiobiology, Division of Nuclear Medicine, Centre hospitalier universitaire de Sherbrooke, Canada (F.B.).
Francois
F
Benard
From the Molecular Function and Imaging Program, The National Cardiac PET Centre, Division of Cardiology, Department of Medicine and the Division of Cardiac Surgery, Department of Surgery and the Cardiac Research Methods Centre, University of Ottawa Heart Institute and University of Ottawa, Canada (B.M., T.S., R.A.D., J.B., A.G., S.P.L., R.A.D., H.H., L.D., P.H., R.M., T.D.R., B.J.C., L.M., J.N.D., L.G., G.A.W., R.S.B.B.); Department of Medicine, Division of General Internal Medicine, University of Washington-Harborview Center for Prehospital Emergency Care, Seattle, (G.N.); Department of Medicine, Divisions of Cardiology, University Health Network and St Michael's Hospital, University of Toronto, Canada (H.R., M.F.); ES Garnett Memorial PET Center, Department of Nuclear Medicine, Hamilton Health Sciences, Canada (K.G.); Department of Medicine, Division of Cardiology, Montréal Heart Institute, Canada (N.R.); Department of Medicine, Division of Cardiology, London Health Sciences Centre, Canada (D.H.); and Department of Molecular Oncology, University of British Columbia, Vancouver, Canada; and Department of Nuclear Medicine and Radiobiology, Division of Nuclear Medicine, Centre hospitalier universitaire de Sherbrooke, Canada (F.B.).
Terrence D
TD
Ruddy
From the Molecular Function and Imaging Program, The National Cardiac PET Centre, Division of Cardiology, Department of Medicine and the Division of Cardiac Surgery, Department of Surgery and the Cardiac Research Methods Centre, University of Ottawa Heart Institute and University of Ottawa, Canada (B.M., T.S., R.A.D., J.B., A.G., S.P.L., R.A.D., H.H., L.D., P.H., R.M., T.D.R., B.J.C., L.M., J.N.D., L.G., G.A.W., R.S.B.B.); Department of Medicine, Division of General Internal Medicine, University of Washington-Harborview Center for Prehospital Emergency Care, Seattle, (G.N.); Department of Medicine, Divisions of Cardiology, University Health Network and St Michael's Hospital, University of Toronto, Canada (H.R., M.F.); ES Garnett Memorial PET Center, Department of Nuclear Medicine, Hamilton Health Sciences, Canada (K.G.); Department of Medicine, Division of Cardiology, Montréal Heart Institute, Canada (N.R.); Department of Medicine, Division of Cardiology, London Health Sciences Centre, Canada (D.H.); and Department of Molecular Oncology, University of British Columbia, Vancouver, Canada; and Department of Nuclear Medicine and Radiobiology, Division of Nuclear Medicine, Centre hospitalier universitaire de Sherbrooke, Canada (F.B.).
Benjamin J
BJ
Chow
From the Molecular Function and Imaging Program, The National Cardiac PET Centre, Division of Cardiology, Department of Medicine and the Division of Cardiac Surgery, Department of Surgery and the Cardiac Research Methods Centre, University of Ottawa Heart Institute and University of Ottawa, Canada (B.M., T.S., R.A.D., J.B., A.G., S.P.L., R.A.D., H.H., L.D., P.H., R.M., T.D.R., B.J.C., L.M., J.N.D., L.G., G.A.W., R.S.B.B.); Department of Medicine, Division of General Internal Medicine, University of Washington-Harborview Center for Prehospital Emergency Care, Seattle, (G.N.); Department of Medicine, Divisions of Cardiology, University Health Network and St Michael's Hospital, University of Toronto, Canada (H.R., M.F.); ES Garnett Memorial PET Center, Department of Nuclear Medicine, Hamilton Health Sciences, Canada (K.G.); Department of Medicine, Division of Cardiology, Montréal Heart Institute, Canada (N.R.); Department of Medicine, Division of Cardiology, London Health Sciences Centre, Canada (D.H.); and Department of Molecular Oncology, University of British Columbia, Vancouver, Canada; and Department of Nuclear Medicine and Radiobiology, Division of Nuclear Medicine, Centre hospitalier universitaire de Sherbrooke, Canada (F.B.).
Lisa
L
Mielniczuk
From the Molecular Function and Imaging Program, The National Cardiac PET Centre, Division of Cardiology, Department of Medicine and the Division of Cardiac Surgery, Department of Surgery and the Cardiac Research Methods Centre, University of Ottawa Heart Institute and University of Ottawa, Canada (B.M., T.S., R.A.D., J.B., A.G., S.P.L., R.A.D., H.H., L.D., P.H., R.M., T.D.R., B.J.C., L.M., J.N.D., L.G., G.A.W., R.S.B.B.); Department of Medicine, Division of General Internal Medicine, University of Washington-Harborview Center for Prehospital Emergency Care, Seattle, (G.N.); Department of Medicine, Divisions of Cardiology, University Health Network and St Michael's Hospital, University of Toronto, Canada (H.R., M.F.); ES Garnett Memorial PET Center, Department of Nuclear Medicine, Hamilton Health Sciences, Canada (K.G.); Department of Medicine, Division of Cardiology, Montréal Heart Institute, Canada (N.R.); Department of Medicine, Division of Cardiology, London Health Sciences Centre, Canada (D.H.); and Department of Molecular Oncology, University of British Columbia, Vancouver, Canada; and Department of Nuclear Medicine and Radiobiology, Division of Nuclear Medicine, Centre hospitalier universitaire de Sherbrooke, Canada (F.B.).
Jean N
JN
DaSilva
From the Molecular Function and Imaging Program, The National Cardiac PET Centre, Division of Cardiology, Department of Medicine and the Division of Cardiac Surgery, Department of Surgery and the Cardiac Research Methods Centre, University of Ottawa Heart Institute and University of Ottawa, Canada (B.M., T.S., R.A.D., J.B., A.G., S.P.L., R.A.D., H.H., L.D., P.H., R.M., T.D.R., B.J.C., L.M., J.N.D., L.G., G.A.W., R.S.B.B.); Department of Medicine, Division of General Internal Medicine, University of Washington-Harborview Center for Prehospital Emergency Care, Seattle, (G.N.); Department of Medicine, Divisions of Cardiology, University Health Network and St Michael's Hospital, University of Toronto, Canada (H.R., M.F.); ES Garnett Memorial PET Center, Department of Nuclear Medicine, Hamilton Health Sciences, Canada (K.G.); Department of Medicine, Division of Cardiology, Montréal Heart Institute, Canada (N.R.); Department of Medicine, Division of Cardiology, London Health Sciences Centre, Canada (D.H.); and Department of Molecular Oncology, University of British Columbia, Vancouver, Canada; and Department of Nuclear Medicine and Radiobiology, Division of Nuclear Medicine, Centre hospitalier universitaire de Sherbrooke, Canada (F.B.).
Linda
L
Garrard
From the Molecular Function and Imaging Program, The National Cardiac PET Centre, Division of Cardiology, Department of Medicine and the Division of Cardiac Surgery, Department of Surgery and the Cardiac Research Methods Centre, University of Ottawa Heart Institute and University of Ottawa, Canada (B.M., T.S., R.A.D., J.B., A.G., S.P.L., R.A.D., H.H., L.D., P.H., R.M., T.D.R., B.J.C., L.M., J.N.D., L.G., G.A.W., R.S.B.B.); Department of Medicine, Division of General Internal Medicine, University of Washington-Harborview Center for Prehospital Emergency Care, Seattle, (G.N.); Department of Medicine, Divisions of Cardiology, University Health Network and St Michael's Hospital, University of Toronto, Canada (H.R., M.F.); ES Garnett Memorial PET Center, Department of Nuclear Medicine, Hamilton Health Sciences, Canada (K.G.); Department of Medicine, Division of Cardiology, Montréal Heart Institute, Canada (N.R.); Department of Medicine, Division of Cardiology, London Health Sciences Centre, Canada (D.H.); and Department of Molecular Oncology, University of British Columbia, Vancouver, Canada; and Department of Nuclear Medicine and Radiobiology, Division of Nuclear Medicine, Centre hospitalier universitaire de Sherbrooke, Canada (F.B.).
George A
GA
Wells
From the Molecular Function and Imaging Program, The National Cardiac PET Centre, Division of Cardiology, Department of Medicine and the Division of Cardiac Surgery, Department of Surgery and the Cardiac Research Methods Centre, University of Ottawa Heart Institute and University of Ottawa, Canada (B.M., T.S., R.A.D., J.B., A.G., S.P.L., R.A.D., H.H., L.D., P.H., R.M., T.D.R., B.J.C., L.M., J.N.D., L.G., G.A.W., R.S.B.B.); Department of Medicine, Division of General Internal Medicine, University of Washington-Harborview Center for Prehospital Emergency Care, Seattle, (G.N.); Department of Medicine, Divisions of Cardiology, University Health Network and St Michael's Hospital, University of Toronto, Canada (H.R., M.F.); ES Garnett Memorial PET Center, Department of Nuclear Medicine, Hamilton Health Sciences, Canada (K.G.); Department of Medicine, Division of Cardiology, Montréal Heart Institute, Canada (N.R.); Department of Medicine, Division of Cardiology, London Health Sciences Centre, Canada (D.H.); and Department of Molecular Oncology, University of British Columbia, Vancouver, Canada; and Department of Nuclear Medicine and Radiobiology, Division of Nuclear Medicine, Centre hospitalier universitaire de Sherbrooke, Canada (F.B.). rbeanlands@ottawaheart.ca.
Rob S B
RS
Beanlands
D000368:Aged; D002170:Canada; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy*; D018572:Disease-Free Survival; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology / Q000401:mortality; D009204:Myocardial Revascularization / Q000009:adverse effects / Q000401:mortality; D009206:Myocardium / Q000473:pathology; D010359:Patient Readmission; D000072078:Positron Emission Tomography Computed Tomography; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals / Q000008:administration & dosage*; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors; D014022:Tissue Survival; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D016277:Ventricular Function, Left
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
fluorodeoxyglucose; heart failure; positron emission tomography; revascularization; viability imaging