Effects of FOXJ2 on TGF-β1-induced epithelial-mesenchymal transition through Notch signaling pathway in non-small lung cancer.
As one member of Forkhead box transcription factors, Forkhead box J2 (FOXJ2) has been found to be involved in epithelial-mesenchymal transition (EMT) process. However, the role and mechanism of FOXJ2 in non-small cell lung cancer (NSCLC) and EMT regulation have not been fully revealed. In this paper, it was revealed that the expression of FOXJ2 was lower in NSCLC samples compared with matched peritumoral lung tissue. We demonstrated that FOXJ2 expression was down-regulated by transforming growth factor-β1 (TGF-β1) treated, and overexpression of FOXJ2 inhibited TGF-β1-induced EMT. Mechanistically, knocking out the expression of FOXJ2 promoted EMT by increasing the expression of Notch1 and NICD. This study implicates the potential value of FOXJ2 as a molecular marker for NSCLC.
Department of Pathology, The Second Affiliated Hospital of Nantong University, Nantong City, Jiangsu Province, China.
Qichang
Q
Yang
Department of Clinical Laboratory, The Second Affiliated Hospital of Nantong University, Nantong City, Jiangsu Province, China.
Xingjian
X
Cao
Department of Clinical Laboratory, The Second Affiliated Hospital of Nantong University, Nantong City, Jiangsu Province, China.
Guohua
G
Tao
Department of Clinical Laboratory, The Second Affiliated Hospital of Nantong University, Nantong City, Jiangsu Province, China.
Feng
F
Zhou
Department of Clinical Laboratory, The Second Affiliated Hospital of Nantong University, Nantong City, Jiangsu Province, China.
Ping
P
Zhao
Department of Pathology, The Second Affiliated Hospital of Nantong University, Nantong City, Jiangsu Province, China.
Yi
Y
Shen
Department of Clinical Laboratory, The Second Affiliated Hospital of Nantong University, Nantong City, Jiangsu Province, China.
Xiang
X
Chen
D000072283:A549 Cells; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism* / Q000473:pathology*; D058750:Epithelial-Mesenchymal Transition / Q000187:drug effects*; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D055786:Gene Knockout Techniques; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism / Q000473:pathology*; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects*; D053773:Transforming Growth Factor beta1 / Q000494:pharmacology*
C408469:FOXJ2 protein, human; D051858:Forkhead Transcription Factors; D051880:Receptors, Notch; D053773:Transforming Growth Factor beta1
EMT; FOXJ2; NSCLC; Notch signaling pathway; TGF-β1