Building Congested Ketone: Substituted Hantzsch Ester and Nitrile as Alkylation Reagents in Photoredox Catalysis.
For the first time, 4-alkyl Hantzsch esters were used to construct molecules with all-carbon quaternary centers by visible light-induced photoredox catalysis via transfer alkylation. Up to a 1500 h(-1) turnover frequency was achieved in this reaction. Reactions of 4-alkyl Hantzsch nitriles as tertiary radical donors joined two contiguous all-carbon quaternary centers intermolecularly, and this chemistry was used to synthesize a common precursor of a class of hydroxysteroid dehydrogenase inhibitors.
Institute of Chemistry and Biomedical Sciences, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing, China.
Wenxin
W
Chen
Institute of Chemistry and Biomedical Sciences, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing, China.
Zheng
Z
Liu
Key Laboratory of Mesoscopic Chemistry of MOE, Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing, China.
Jiaqi
J
Tian
Institute of Chemistry and Biomedical Sciences, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing, China.
Jin
J
Li
Key Laboratory of Mesoscopic Chemistry of MOE, Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing, China.
Jing
J
Ma
Institute of Chemistry and Biomedical Sciences, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing, China.
Xu
X
Cheng
Institute of Chemistry and Biomedical Sciences, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing, China.|Department of Chemistry and Biochemistry, Texas Tech University , Lubbock, Texas 79409, United States.
Guigen
G
Li