Effects of social isolation, re-socialization and age on cognitive and aggressive behaviors of Kunming mice and BALB/c mice.
Both Kunming (KM) mice and BALB/c mice have been widely used as rodent models to investigate stress-associated mental diseases. However, little is known about the different behaviors of KM mice and BALB/c mice after social isolation, particularly cognitive and aggressive behaviors. In this study, the behaviors of KM and BALB/c mice isolated for 2, 4 and 8 weeks and age-matched controls were evaluated using object recognition, object location and resident-intruder tests. The recovery of behavioral deficits by re-socialization was also examined for the isolated mice in adolescence. Our study showed that isolation for 2, 4 and 8 weeks led to cognitive deficits and increased aggressiveness for both KM and BALB/c mice. An important finding is that re-socialization could completely recover spatial/non-spatial cognitive deficits resulted from social isolation for both KM and BALB/c mice. In addition, age only impacted aggressiveness of KM mice. Moreover, isolation duration showed different impacts on cognitive and aggressive behaviors for both KM and BALB/c mice. Furthermore, BALB/c mice showed weak spatial/non-spatial memory and low aggressiveness when they were at the same age and isolation duration, compared to KM mice. In conclusion, KM mice and BALB/c mice behaved characteristically under physiology and isolation conditions.
College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
Dong
D
An
College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
Wei
W
Chen
College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
De-Qin
DQ
Yu
Menzies Research Institute, University of Tasmania, Hobart, Australia.
Shi-Wei
SW
Wang
College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
Wei-Zhi
WZ
Yu
College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
Hong
H
Xu
College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
Dong-Mei
DM
Wang
College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
Dan
D
Zhao
College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
Yi-Ping
YP
Sun
College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
Jun-Cheng
JC
Wu
Texas Tech Neuroimaging Institute, Texas Tech University, Lubbock of Texas, USA.
Yi-Yuan
YY
Tang
College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
Sheng-Ming
SM
Yin
D000374:Aggression; D000375:Aging / Q000523:psychology*; D000818:Animals; D003071:Cognition; D004195:Disease Models, Animal; D008297:Male; D001523:Mental Disorders / Q000523:psychology*; D051379:Mice; D008807:Mice, Inbred BALB C; D012934:Social Isolation / Q000523:psychology*; D012951:Socialization; D013997:Time Factors
BALB/c mice; behavior; kunming mice; social isolation