Direct and Oxidant-Free Electron-Deficient Arylation of N-Acyl-Protected Tetrahydroisoquinolines.
A direct α-C-H electron-deficient arylation reaction of N-acyl protected tetrahydroisoquinolines is developed via visible light photoredox catalysis. The reaction was performed under mild conditions without any extra oxidant and could also proceed smoothly when sunlight was used as the light source. The protecting group on the tetrahydroisoquinolines could be removed easily.
State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Nankai University , Tianjin 300071, People's Republic of China.
Changcun
C
Yan
State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Nankai University , Tianjin 300071, People's Republic of China.
Lili
L
Li
State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Nankai University , Tianjin 300071, People's Republic of China.
Yuxiu
Y
Liu
State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Nankai University , Tianjin 300071, People's Republic of China.|Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , Tianjin 300071, People's Republic of China.
Qingmin
Q
Wang