Clinical Significance of Circulating Osteopontin Levels in Patients With Lung Cancer and Correlation With VEGF and MMP-9.
Osteopontin (OPN) is a multifunctional cytokine involved in carcinogenesis. Serum levels of OPN, vascular endothelial growth factor (VEGF), and matrix metalloproteinase-9 (MMP-9) were measured by ELISA in 90 lung cancer patients. OPN levels were elevated in patients compared to controls (p <.0001). Smokers, patients with worse performance status, and weight loss exhibited higher OPN levels (p =.0012,.00036, and.0003, respectively). Increased OPN levels were associated with worse survival (p =.0018). Finally, OPN levels were positively correlated with both VEGF (p =.0008) and MMP-9 (p <.0001). OPN might serve as a prognostic biomarker, and the positive correlation between OPN and both VEGF and MMP-9 could implicate new insights in tumor angiogenesis.
a Respiratory Medicine Department , University of Thessaly Medical School, University Hospital of Larissa , Larissa , Greece.
Theodora
T
Kerenidi
a Respiratory Medicine Department , University of Thessaly Medical School, University Hospital of Larissa , Larissa , Greece.
Aikaterini P
AP
Kazakou
a Respiratory Medicine Department , University of Thessaly Medical School, University Hospital of Larissa , Larissa , Greece.
Martha
M
Lada
a Respiratory Medicine Department , University of Thessaly Medical School, University Hospital of Larissa , Larissa , Greece.
Irini
I
Tsilioni
a Respiratory Medicine Department , University of Thessaly Medical School, University Hospital of Larissa , Larissa , Greece.
Zoe
Z
Daniil
a Respiratory Medicine Department , University of Thessaly Medical School, University Hospital of Larissa , Larissa , Greece.
Konstantinos I
KI
Gourgoulianis
D000368:Aged; D014408:Biomarkers, Tumor; D001706:Biopsy; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000401:mortality; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic; D053495:Osteopontin / Q000097:blood*; D011379:Prognosis; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
D014408:Biomarkers, Tumor; D042461:Vascular Endothelial Growth Factor A; D053495:Osteopontin; D020780:Matrix Metalloproteinase 9
Prognostic studies; angiogenesis; cancer biomarkers; lung cancer