Microarray Analysis of 8p23.1 Deletion in New Patients with Atypical Phenotypical Traits.
We describe two patients carrying deletions of chromosome 8p23.1 with a commonly critical region identified by means of oligonucleotide array comparative genomic hybridization (array CGH). They didn't present congenital heart defects or behavioral problems. Only one patient presented with intellectual disability and carrying deletion of TNKS gene. We presumed the inclusion of TNKS gene in the mental impairment.
Cytogenetic and Reproductive Biology Department, Farhat Hached University Teaching Hospital, Sousse, Tunisia; Common Service Units for Research in Genetics, Faculty of Medicine of Sousse, University of Sousse, Tunisia.
Hela Ben
HB
Khelifa
Cytogenetic and Reproductive Biology Department, Farhat Hached University Teaching Hospital, Sousse, Tunisia; Common Service Units for Research in Genetics, Faculty of Medicine of Sousse, University of Sousse, Tunisia.
Molka
M
Kammoun
Cytogenetic and Reproductive Biology Department, Farhat Hached University Teaching Hospital, Sousse, Tunisia; Common Service Units for Research in Genetics, Faculty of Medicine of Sousse, University of Sousse, Tunisia.
Hanene
H
Hannachi
Pediatric Department, Farhat Hached University Teaching Hospital, Sousse, Tunisia.
Najla
N
Soyah
Pediatric Department, Fattouma Bourguiba University Teaching Hospital, Monastir, Tunisia.
Saber
S
Hammami
Cytogenetic and Reproductive Biology Department, Farhat Hached University Teaching Hospital, Sousse, Tunisia; Common Service Units for Research in Genetics, Faculty of Medicine of Sousse, University of Sousse, Tunisia.
Hatem
H
Elghezal
Cytogenetic Department, Biological and Pathological Center EST, Bron, Lyon- France.
Damien
D
Sanlaville
Cytogenetic and Reproductive Biology Department, Farhat Hached University Teaching Hospital, Sousse, Tunisia; Common Service Units for Research in Genetics, Faculty of Medicine of Sousse, University of Sousse, Tunisia.
Ali
A
Saad
Cytogenetic and Reproductive Biology Department, Farhat Hached University Teaching Hospital, Sousse, Tunisia; Common Service Units for Research in Genetics, Faculty of Medicine of Sousse, University of Sousse, Tunisia.
Soumaya
S
Mougou-Zerelli
8p deletion; CGH array; TNKS gene; intellectual disability