A Computational Method for Optimizing Experimental Environments for Phellinus igniarius via Genetic Algorithm and BP Neural Network.
Flavones, the secondary metabolites of Phellinus igniarius fungus, have the properties of antioxidation and anticancer. Because of the great medicinal value, there are large demands on flavones for medical use and research. Flavones abstracted from natural Phellinus can not meet the medical and research need, since Phellinus in the natural environment is very rare and is hard to be cultivated artificially. The production of flavones is mainly related to the fermentation culture of Phellinus, which made the optimization of culture conditions an important problem. Some researches were made to optimize the fermentation culture conditions, such as the method of response surface methodology, which claimed the optimal flavones production was 1532.83 μg/mL. In order to further optimize the fermentation culture conditions for flavones, in this work a hybrid intelligent algorithm with genetic algorithm and BP neural network is proposed. Our method has the intelligent learning ability and can overcome the limitation of large-scale biotic experiments. Through simulations, the optimal culture conditions are obtained and the flavones production is increased to 2200 μg/mL.
College of Computer and Communication Engineering, China University of Petroleum, Qingdao, Shandong 266580, China.
Zhongwei
Z
Li
College of Computer and Communication Engineering, China University of Petroleum, Qingdao, Shandong 266580, China.
Beibei
B
Sun
College of Computer and Communication Engineering, China University of Petroleum, Qingdao, Shandong 266580, China.
Yuezhen
Y
Xin
College of Computer and Communication Engineering, China University of Petroleum, Qingdao, Shandong 266580, China; Center for Bioengineering and Biotechnology, China University of Petroleum, Qingdao, Shandong 266580, China.
Xun
X
Wang
Center for Bioengineering and Biotechnology, China University of Petroleum, Qingdao, Shandong 266580, China.
Hu
0000-0002-0478-6392
H
Zhu
D000465:Algorithms; D000972:Antineoplastic Agents, Phytogenic / Q000096:biosynthesis; D000975:Antioxidants / Q000378:metabolism; D001487:Basidiomycota / Q000378:metabolism*; D005285:Fermentation; D047309:Flavones / Q000096:biosynthesis*; D000069550:Machine Learning; D008516:Medicine, Chinese Traditional; D016571:Neural Networks, Computer
D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D047309:Flavones