Two gene polymorphisms (rs4977756 and rs11515) in CDKN2A/B and glioma risk in South Indian population.
Gliomas are most common neoplasms in the CNS with unknown aetiology. Gene polymorphisms have been studied in glioma to check its risk in different population. CDKN2A, commonly altered tumor suppressor gene polymorphisms were recently shown to be associated with glioma in Caucasians. Present study evaluated potential association between two SNPs in CDKN2A/B gene with glioma risk in South Indian population with a total of 128 cases and 140 control subjects. Allelic discrimination assay was used for the genotyping and the association of each SNP with glioma risk were calculated using odds ratio and 95% CI. There was no association between rs4977756 polymorphism and glioma risk in south Indian population. GG genotype had a non-significant low risk in glioma (OR = 0.69). rs11515 polymorphism was not in Hardy Weinberg Equilibrium in our sample, so it was not considered for association studies. There was difference in genotype in tissue samples paired with blood samples for rs4977756 polymorphism, suggesting the importance of tissue SNP status in association studies. These results show that these two polymorphisms may not contribute to risk for glioma in South Indian population.
Department of Human Genetics, National Institute of Mental Health and Neuro Sciences, Bangalore 560029, India.
M K
MK
Sibin
Department of Neurosurgery, National Institute of Mental Health and Neuro Sciences, Bangalore 560029, India.
I Bhat
IB
Dhananjaya
Department of Neurosurgery, National Institute of Mental Health and Neuro Sciences, Bangalore 560029, India.
K V L
KV
Narasingarao
Department of Human Genetics, National Institute of Mental Health and Neuro Sciences, Bangalore 560029, India.
S M
SM
Harshitha
Department of Human Genetics, National Institute of Mental Health and Neuro Sciences, Bangalore 560029, India.
M
M
Jeru-Manoj
Department of Human Genetics, National Institute of Mental Health and Neuro Sciences, Bangalore 560029, India.
G K
GK
Chetan
CDKN2A; Glioma; Polymorphism; rs11515; rs4977756