Lorentz force optical coherence elastography.
Quantifying tissue biomechanical properties can assist in detection of abnormalities and monitoring disease progression and/or response to a therapy. Optical coherence elastography (OCE) has emerged as a promising technique for noninvasively characterizing tissue biomechanical properties. Several mechanical loading techniques have been proposed to induce static or transient deformations in tissues, but each has its own areas of applications and limitations. This study demonstrates the combination of Lorentz force excitation and phase-sensitive OCE at ?1.5??million A-lines per second to quantify the elasticity of tissue by directly imaging Lorentz force-induced elastic waves. This method of tissue excitation opens the possibility of a wide range of investigations using tissue biocurrents and conductivity for biomechanical analysis.
University of Houston, Department of Biomedical Engineering, 3605 Cullen Boulevard, Houston, Texas 77204, United States.
Chen
C
Wu
University of Houston, Department of Biomedical Engineering, 3605 Cullen Boulevard, Houston, Texas 77204, United States.
Manmohan
M
Singh
University of Houston, Department of Biomedical Engineering, 3605 Cullen Boulevard, Houston, Texas 77204, United States.
Zhaolong
Z
Han
University of Houston, Department of Biomedical Engineering, 3605 Cullen Boulevard, Houston, Texas 77204, United States.
Raksha
R
Raghunathan
University of Houston, Department of Biomedical Engineering, 3605 Cullen Boulevard, Houston, Texas 77204, United States.
Chih-Hao
CH
Liu
University of Houston, Department of Biomedical Engineering, 3605 Cullen Boulevard, Houston, Texas 77204, United States.
Jiasong
J
Li
University of Houston, Department of Biomedical Engineering, 3605 Cullen Boulevard, Houston, Texas 77204, United States.
Alexander
A
Schill
University of Houston, Department of Biomedical Engineering, 3605 Cullen Boulevard, Houston, Texas 77204, United StatesbTomsk State University, Interdisciplinary Laboratory of Biophotonics, 36 Lenin Avenue, Tomsk 634050, RussiacBaylor College of Medicine, Molecular Physiology and Biophysics, One Baylor Plaza, Houston, Texas 77030, United States.
Kirill V
KV
Larin
D000818:Animals; D054459:Elasticity Imaging Techniques / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D007091:Image Processing, Computer-Assisted; D008099:Liver / Q000000981:diagnostic imaging; D019047:Phantoms, Imaging; D012815:Signal Processing, Computer-Assisted; D013552:Swine; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods*