Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus.
A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10(-20)), ER-negative BC (P=1.1 × 10(-13)), BRCA1-associated BC (P=7.7 × 10(-16)) and triple negative BC (P-diff=2 × 10(-5)). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10(-3)) and ABHD8 (P<2 × 10(-3)). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3'-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk.
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Kate
K
Lawrenson
Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Siddhartha
S
Kar
QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia.
Karen
K
McCue
Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Karoline
K
Kuchenbaeker
Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Kyriaki
K
Michailidou
Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Jonathan
J
Tyrer
QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia.
Jonathan
J
Beesley
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Susan J
SJ
Ramus
Medical College, Xiamen University, Xiamen 361102, China.|Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
Qiyuan
Q
Li
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Melissa K
MK
Delgado
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Janet M
JM
Lee
Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki 00029 HUS, Finland.
Kristiina
K
Aittomäki
Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.|Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Irene L
IL
Andrulis
Department of Epidemiology, Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine, Irvine, California 92697, USA.
Hoda
H
Anton-Culver
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
Volker
V
Arndt
University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Banu K
BK
Arun
Department of Oncology, Karolinska University Hospital, Stockholm 171 77, Sweden.
Brita
B
Arver
Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA.
Elisa V
EV
Bandera
Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan 20141, Italy.
Monica
M
Barile
Department of Pathology, Landspitali University Hospital and BMC (Biomedical Centre), Faculty of Medicine, University of Iceland, Reykjavik 600169-2039, Iceland.
Rosa B
RB
Barkardottir
Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Daniel
D
Barrowdale
University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen 91054, Germany.
Matthias W
MW
Beckmann
Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid E-28029, Spain.|Centro de Investigación en Red de Enfermedades Raras, Valencia 28029, Spain.
Javier
J
Benitez
Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Andrew
A
Berchuck
Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York 10065, USA.
Maria
M
Bisogna
Department of Gynecology and Obstetrics, Haukeland University Hospital, 5021 Bergen, Norway.|Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, N-5020 Bergen, Norway.
Line
L
Bjorge
Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki FIN-00029, Finland.
Carl
C
Blomqvist
Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.|International Epidemiology Institute, Rockville, Maryland 20850, USA.
William
W
Blot
Gynaecology Research Unit, Hannover Medical School, Hannover D-30625, Germany.
Natalia
N
Bogdanova
Department of Clinical Genetics, Vejle Hospital, Vejle 7100, Denmark.
Anders
A
Bojesen
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.|Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev 2730, Denmark.|Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev 2730, Denmark.
Stig E
SE
Bojesen
Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Manjeet K
MK
Bolla
Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan 20141, Italy.
Bernardo
B
Bonanni
Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo N-0310, Norway.|K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo N-0310, Norway.
Anne-Lise
AL
Børresen-Dale
Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart D-70376, Germany.|University of Tübingen, Tübingen 72074, Germany.|German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Hiltrud
H
Brauch
International Agency for Research on Cancer, Lyon 69008, France.
Paul
P
Brennan
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.|German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.|Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany.
Hermann
H
Brenner
Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.
Fiona
F
Bruinsma
Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, Girona 08908, Spain.
Joan
J
Brunet
Department of Surgery, National University Health System, Singapore 119077, Singapore.
Shaik Ahmad
SA
Buhari
Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.|Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg 69120, Germany.
Barbara
B
Burwinkel
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki 00029 HUS, Finland.|Department of Pathology, Helsinki University Central Hospital, Helsinki 00029, Finland.
Ralf
R
Butzow
Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.
Saundra S
SS
Buys
Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
Qiuyin
Q
Cai
Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid 28040, Spain.
Trinidad
T
Caldes
Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria 3002, Australia.
Ian
I
Campbell
Cancer Pathology &Prevention, Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo 14263, New York, USA.
Rikki
R
Canniotto
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany.|University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.
Jenny
J
Chang-Claude
Unité de recherche en santé des populations, Centre des maladies du sein Deschênes-Fabia, Centre de recherche FRSQ du Centre hospitalier affilié universitaire de Québec, Québec City, Québec G1J 1Z4, Canada.
Jocelyne
J
Chiquette
Cancer Research Institute, Seoul National University, Seoul 08826, Korea.|Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Korea.
Ji-Yeob
JY
Choi
Center for Medical Genetics, Ghent University, Ghent 9000, Belgium.
Kathleen B M
KB
Claes
Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico 87131, USA.
Linda S
LS
Cook
Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield S10 2TN, UK.
Angela
A
Cox
Harvard HT Chan School of Public Health, Boston, Massachusetts 02115, USA.|Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Daniel W
DW
Cramer
Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield S10 2TN, UK.
Simon S
SS
Cross
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin 70-115, Poland.
Cezary
C
Cybulski
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-171 77, Sweden.
Kamila
K
Czene
Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.
Mary B
MB
Daly
INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon 69373, France.
Francesca
F
Damiola
Department of Pathology and Laboratory Diagnostics the Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Warsaw 44-101, Poland.
Agnieszka
A
Dansonka-Mieszkowska
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-171 77, Sweden.
Hatef
H
Darabi
Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Joe
J
Dennis
Department of Pathology, Leiden University Medical Center, Leiden 2333, The Netherlands.|Department of Human Genetics, Leiden University Medical Center, Leiden 2333, The Netherlands.
Peter
P
Devilee
Oncogenetics Group, University Hospital Vall d'Hebron, Vall d'Hebron Institute of Oncology (VHIO) and Universitat Autònoma de Barcelona, Barcelona 08035, Spain.
Orland
O
Diez
Department of Community and Family Medicine, Section of Biostatistics &Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire 03755, USA.
Jennifer A
JA
Doherty
Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Susan M
SM
Domchek
Department of Genetics, University of Pretoria, Pretoria 0083, South Africa.
Cecilia M
CM
Dorfling
Gynaecology Research Unit, Hannover Medical School, Hannover D-30625, Germany.
Thilo
T
Dörk
Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Québec G1V 4G2, Canada.
Martine
M
Dumont
Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 751 05, Sweden.|Department of Clinical Genetics, Lund University Hospital, Lund 221 00, Sweden.
Hans
H
Ehrencrona
Department of Oncology, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.
Bent
B
Ejlertsen
Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Steve
S
Ellis
Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04107 Leipzig, Germany.
Christoph
C
Engel
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Eunjung
E
Lee
Genomic Medicine, Manchester Academic Health Sciences Centre, Institute of Human Development, Manchester University, Central Manchester University Hospitals NHS Foundation Trust, Manchester M13 9PL, UK.
D Gareth
DG
Evans
University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen 91054, Germany.|University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, Los Angeles California 90095, USA.
Peter A
PA
Fasching
Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute),Catalan Institute of Oncology, Barcelona 08908, Spain.
Lidia
L
Feliubadalo
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, USA.
Jonine
J
Figueroa
Institute for Medical Biometrics and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.|Department of Cancer Epidemiology, Clinical Cancer Registry, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.
Dieter
D
Flesch-Janys
Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.|Division of Breast Cancer Research, The Institute of Cancer Research, London SW7 3RP, UK.
Olivia
O
Fletcher
Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark.
Henrik
H
Flyger
Masaryk Memorial Cancer Institute and Medical Faculty MU, 625 00 Brno, Czech Republic.
Lenka
L
Foretova
Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis, Athens 153 10, Greece.
Florentia
F
Fostira
Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Montreal, Quebec H2W 1S6, Canada.
William D
WD
Foulkes
Biostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, Kansas 66160, USA.
Brooke L
BL
Fridley
Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer 52621, Israel.
Eitan
E
Friedman
Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Debra
D
Frost
Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa, Pisa 56126, Italy.
Gaetana
G
Gambino
UCLA Schools of Medicine and Public Health, Division of Cancer Prevention &Control Research, Jonsson Comprehensive Cancer Center, Los Angeles, California 90024, USA.
Patricia A
PA
Ganz
Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
Judy
J
Garber
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, USA.|Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.
Montserrat
M
García-Closas
Women's Cancer, UCL EGA Institute for Women's Health, London WC1E 6AU, UK.
Aleksandra
A
Gentry-Maharaj
Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Maya
M
Ghoussaini
Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.|Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia.
Graham G
GG
Giles
Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow G12 0YN, UK.
Rosalind
R
Glasspool
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA.
Andrew K
AK
Godwin
Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montreal, Québec H3A 1A1, Canada.|Department of Medicine, McGill University, Montreal, Québec H3A 1A1, Canada.
Mark S
MS
Goldberg
Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA.
David E
DE
Goldgar
Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid E-28029, Spain.
Anna
A
González-Neira
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55902, USA.
Ellen L
EL
Goode
Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.|Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
Marc T
MT
Goodman
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20892, USA.
Mark H
MH
Greene
Department of Genetics and Pathology, Pomeranian Medical University, 70-204 Szczecin, Poland.
Jacek
J
Gronwald
Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, 94805 Villejuif, France.|University Paris-Sud, 91405 Villejuif, France.
Pascal
P
Guénel
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Christopher A
CA
Haiman
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-171 77, Sweden.
Per
P
Hall
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55902, USA.
Emily
E
Hallberg
Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Ute
U
Hamann
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.
Thomas V O
TV
Hansen
Department of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK.
Patricia A
PA
Harrington
Department of Surgery, National University Health System, Singapore 119077, Singapore.|Saw Swee Hock School of Public Health, National University of Singapore Singapore 119077, Singapore.
Mikael
M
Hartman
Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, 50603 Kuala Lumpur, Malaysia.|Cancer Research Initiatives Foundation, Subang Jaya, 47500 Selangor, Malaysia.
Norhashimah
N
Hassan
QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia.
Sue
S
Healey
Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, 45136 Essen, Germany.|Department of Gynecology and Gynecologic Oncology, Dr Horst Schmidt Kliniken Wiesbaden, 65199 Wiesbaden, Germany.
Florian
F
Heitz
Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network, Duarte California 91010, USA.
Josef
J
Herzog
Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, 2730 Copenhagen, Denmark.|Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, DK-2100 Copenhagen, Denmark.
Estrid
E
Høgdall
Department of Gynecology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.
Claus K
CK
Høgdall
Family Cancer Clinic, Netherlands Cancer Institute, 1006 Amsterdam, The Netherlands.
Frans B L
FB
Hogervorst
Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, 3015 Rotterdam, The Netherlands.
Antoinette
A
Hollestelle
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia.
John L
JL
Hopper
Center for Medical Genetics, NorthShore University Health System, Evanston, Illinois, 60201, USA.
Peter J
PJ
Hulick
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin 70-115, Poland.
Tomasz
T
Huzarski
N.N. Petrov Institute of Oncology, St Petersburg 197758, Russia.
Evgeny N
EN
Imyanitov
Lombardi Comprehensive Cancer Center, Georgetown University, Washington District of Columbia 20057, USA.
Claudine
C
Isaacs
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Aichi 464-8681, Japan.
Hidemi
H
Ito
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin 70-115, Poland.
Anna
A
Jakubowska
State Research Institute Centre for Innovative Medicine, LT-01102 Vilnius, Lithuania.
Ramunas
R
Janavicius
Department of Gynecology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.
Allan
A
Jensen
Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California 94538, USA.
Esther M
EM
John
Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.|Division of Breast Cancer Research, The Institute of Cancer Research, London SW7 3RP, UK.
Nichola
N
Johnson
Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Maria
M
Kabisch
Cancer Research Institute, Seoul National University, Seoul 08826, Korea.|Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Korea.|Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 08826, Korea.
Daehee
D
Kang
Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Victoria 3010, Australia.
Miroslav
M
Kapuscinski
Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
Beth Y
BY
Karlan
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki 00029 HUS, Finland.
Sofia
S
Khan
Radboud University Medical Centre, Radboud Institute for Health Sciences, 6500 Nijmegen, The Netherlands.
Lambertus A
LA
Kiemeney
Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, DK-2100 Copenhagen, Denmark.|Department of Gynecology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.
Susanne Kruger
SK
Kjaer
Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.|Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario M5T 3M7, Canada.
Julia A
JA
Knight
Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis, Athens 153 10, Greece.
Irene
I
Konstantopoulou
Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, 70210 Kuopio, Finland.|Cancer Center, Kuopio University Hospital, 70210 Kuopio, Finland.|Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, 70210 Kuopio, Finland.
Veli-Matti
VM
Kosma
Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo N-0310, Norway.|K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo N-0310, Norway.|Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, 1478 Oslo, Norway.
Vessela
V
Kristensen
Department of Pathology and Laboratory Diagnostics the Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Warsaw 44-101, Poland.
Jolanta
J
Kupryjanczyk
The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong, China.|Department of Surgery, The University of Hong Kong, Hong Kong, China.
Ava
A
Kwong
Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid 28040, Spain.
Miguel
M
de la Hoya
Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer 52621, Israel.
Yael
Y
Laitman
Vesalius Research Center, VIB, 3000 Leuven, Belgium.|Laboratory for Translational Genetics, Department of Oncology, University of Leuven, 3000 Leuven, Belgium.
Diether
D
Lambrechts
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Nhu
N
Le
Center for Medical Genetics, Ghent University, Ghent 9000, Belgium.
Kim
K
De Leeneer
Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
Jenny
J
Lester
Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York 10065, USA.
Douglas A
DA
Levine
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-171 77, Sweden.
Jingmei
J
Li
Department of Molecular Medicine and Surgery, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Annika
A
Lindblom
Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
Jirong
J
Long
Division of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK.
Artitaya
A
Lophatananon
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20892, USA.
Jennifer T
JT
Loud
Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Karen
K
Lu
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin 70-115, Poland.
Jan
J
Lubinski
Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, 70210 Kuopio, Finland.|Cancer Center, Kuopio University Hospital, 70210 Kuopio, Finland.|Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, 70210 Kuopio, Finland.
Arto
A
Mannermaa
Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), 20133 Milan, Italy.
Siranoush
S
Manoukian
University of Hawaii Cancer Center, Honolulu, Hawaii 96813, USA.
Loic
L
Le Marchand
Department of Oncology - Pathology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Sara
S
Margolin
Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg 69120, Germany.|National Center for Tumour Diseases, University of Heidelberg, 69117 Heidelberg, Germany.
Frederik
F
Marme
Department of Gynaecology, Radboud University Medical Centre, 6500 Nijmegen, The Netherlands.
Leon F A G
LF
Massuger
Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka 812-8582, Japan.
Keitaro
K
Matsuo
INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon 69373, France.
Sylvie
S
Mazoyer
Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Lesley
L
McGuffog
Anatomical Pathology, The Alfred Hospital, Melbourne, Victoria 3004, Australia.
Catriona
C
McLean
Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, Glasgow G61 1BD, UK.
Iain
I
McNeish
Division of Gynaecology and Obstetrics, Technische Universität München, 81675 Munich, Germany.
Alfons
A
Meindl
Women's Cancer, UCL EGA Institute for Women's Health, London WC1E 6AU, UK.
Usha
U
Menon
Department of Human Genetics, Radboud University Medical Centre, 6500 Nijmegen, The Netherlands.
Arjen R
AR
Mensenkamp
Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.|Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia.
Roger L
RL
Milne
Immunology and Molecular Oncology Unit, Instituto Oncologico Veneto IOV, IRCCS, 35128 Padua, Italy.
Marco
M
Montagna
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
Kirsten B
KB
Moysich
Division of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK.|Institute of Population Health, University of Manchester, Manchester M13 9PL, UK.
Kenneth
K
Muir
Laboratory Medicine Program, University Health Network, Toronto, Ontario M5G 1L7, Canada.|Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
Anna Marie
AM
Mulligan
Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Katherine L
KL
Nathanson
The University of Texas School of Public Health, Houston, Texas 77030, USA.
Roberta B
RB
Ness
Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California 91010, USA.
Susan L
SL
Neuhausen
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki 00029 HUS, Finland.
Heli
H
Nevanlinna
K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo N-0310, Norway.
Silje
S
Nord
Department of Medicine and Genetics, University of California, San Francisco, California 94143, USA.
Robert L
RL
Nussbaum
Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
Kunle
K
Odunsi
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York 10065, USA.
Kenneth
K
Offit
Department of Molecular Genetics, National Institute of Oncology, 1122 Budapest, Hungary.
Edith
E
Olah
Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, Illinois 60637, USA.
Olufunmilayo I
OI
Olopade
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55902, USA.
Janet E
JE
Olson
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55902, USA.
Curtis
C
Olswold
The Ohio State University and the James Cancer Center, Columbus, Ohio 43210, USA.
David
D
O'Malley
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York 10017, USA.
Irene
I
Orlow
Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.
Nick
N
Orr
Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), 28019 Madrid, Spain.|Biomedical Network on Rare Diseases (CIBERER), 28029 Madrid, Spain.
Ana
A
Osorio
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Korea.|Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 08826, Korea.|Department of Surgery, Seoul National University College of Medicine, Seoul, 03080 Korea.
Sue Kyung
SK
Park
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Celeste L
CL
Pearce
Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon 97239, USA.|Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon 97239, USA.
Tanja
T
Pejovic
IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, 16 20139 Milan, Italy.
Paolo
P
Peterlongo
Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.
Georg
G
Pfeiler
Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida 33606, USA.
Catherine M
CM
Phelan
Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.|Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, Massachusetts 02115, USA.
Elizabeth M
EM
Poole
Laboratory of Cancer Genetics and Tumour Biology, Northern Finland Laboratory Centre NordLab, FI-90014 Oulu, Finland.|Laboratory of Cancer Genetics and Tumour Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, FI-90014 Oulu, Finland.
Katri
K
Pylkäs
Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), 20133 Milan, Italy.
Paolo
P
Radice
Department of Clinical Genetics, Karolinska University Hospital, 171 76 Stockholm, Sweden.
Johanna
J
Rantala
Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.|Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH &RC), Lahore 54000, Pakistan.
Muhammad Usman
MU
Rashid
Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Haifa 34362, Israel.
Gad
G
Rennert
Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Valerie
V
Rhenius
Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, 50931 Cologne, Germany.
Kerstin
K
Rhiem
Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut 06510, USA.
Harvey A
HA
Risch
Division of Gynecologic Oncology, NorthShore University HealthSystem, Evanston, Illinois 60201, USA.
Gus
G
Rodriguez
Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.|Department of Epidemiology, University of Washington, Seattle, Washington 98109, USA.
Mary Anne
MA
Rossing
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany.
Anja
A
Rudolph
Department of Gynecology and Obstetrics, Haukeland University Hospital, 5021 Bergen, Norway.|Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, N-5020 Bergen, Norway.
Helga B
HB
Salvesen
National Cancer Institute, Bangkok 10400, Thailand.
Suleeporn
S
Sangrajrang
Research Oncology, Guy's Hospital, King's College London, London SE1 9RT, UK.
Elinor J
EJ
Sawyer
Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.|Cancer Control and Population Sciences, Duke Cancer Institute, Durham, North Carolina 27710, USA.
Joellen M
JM
Schildkraut
Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, The Netherlands.
Marjanka K
MK
Schmidt
Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, 50676 Cologne, Germany.|Center for Integrated Oncology, University Hospital of Cologne, 50676 Cologne, Germany.|Center for Molecular Medicine, University Hospital of Cologne, 50676 Cologne, Germany.|Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne, 50676 Cologne, Germany.
Rita K
RK
Schmutzler
Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida 33606, USA.
Thomas A
TA
Sellers
Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, 3015 Rotterdam, The Netherlands.
Caroline
C
Seynaeve
Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Mitul
M
Shah
Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.|School of Public Health, China Medical University, Taichung 404, Taiwan.
Chen-Yang
CY
Shen
Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
Xiao-Ou
XO
Shu
Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford California 94305, USA.
Weiva
W
Sieh
Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.
Christian F
CF
Singer
Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon - Centre Léon Bérard, Lyon 69008, France.|INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon 69003, France.
Olga M
OM
Sinilnikova
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55902, USA.
Susan
S
Slager
Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Honglin
H
Song
Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Québec G1V 4G2, Canada.
Penny
P
Soucy
Department of Pathology, University of Melbourne, Parkville, Victoria 3010, Australia.
Melissa C
MC
Southey
Department of Clinical Genetics, Lund University Hospital, Lund 221 00, Sweden.|Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University, 581 83 Linköping, Sweden.
Marie
M
Stenmark-Askmalm
Institut Curie, Department of Tumour Biology, Paris, France; Institut Curie, INSERM U830, 75248 Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, 75270 Paris, France.
Dominique
D
Stoppa-Lyonnet
Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Christian
C
Sutter
Division of Breast Cancer Research, The Institute of Cancer Research, London SW7 3RP, UK.|Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.
Anthony
A
Swerdlow
Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
Sandrine
S
Tchatchou
Department of Genetics, Portuguese Oncology Institute, Porto 4200-072, Portugal.|Biomedical Sciences Institute (ICBAS), Porto University, Porto 4099-002, Portugal.
Manuel R
MR
Teixeira
Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, 50603 Kuala Lumpur, Malaysia.|Cancer Research Initiatives Foundation, Subang Jaya, 47500 Selangor, Malaysia.
Soo H
SH
Teo
Harvard HT Chan School of Public Health, Boston, Massachusetts 02115, USA.|Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Kathryn L
KL
Terry
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York 10027, USA.
Mary Beth
MB
Terry
Department of Clinical Genetics, Odense University Hospital, 5000 Odense C, Denmark.
Mads
M
Thomassen
UO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria, 21100 Varese, Italy.
Maria Grazia
MG
Tibiletti
Latvian Biomedical Research and Study Centre, Riga LV-1067, Latvia.
Laima
L
Tihomirova
Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico), 64 - 35128 Padua, Italy.
Silvia
S
Tognazzo
Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio 43210, USA.
Amanda Ewart
AE
Toland
Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford OX3 7BN, UK.
Ian
I
Tomlinson
Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.|Institute of Human Genetics, Pontificia Universidad Javeriana, Cra. 7 #40-62 Bogota, Colombia.
Diana
D
Torres
Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, 94805 Villejuif, France.|University Paris-Sud, 91405 Villejuif, France.
Thérèse
T
Truong
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Chiu-Chen
CC
Tseng
Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.
Nadine
N
Tung
Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.|Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, Massachusetts 02115, USA.
Shelley S
SS
Tworoger
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55902, USA.
Celine
C
Vachon
Department of Clinical Genetics, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.
Ans M W
AM
van den Ouweland
Department of Gynecology, Family Cancer Clinic, Erasmus MC Cancer Institute, 3015 CE Rotterdam, The Netherlands.
Helena C
HC
van Doorn
Department of Genetics, University of Pretoria, Pretoria 0083, South Africa.
Elizabeth J
EJ
van Rensburg
Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, The Netherlands.
Laura J
LJ
Van't Veer
Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, B-3000 Leuven, Belgium.
Adriaan
A
Vanderstichele
Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, B-3000 Leuven, Belgium.
Ignace
I
Vergote
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York 10065, USA.
Joseph
J
Vijai
Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Qin
Q
Wang
Shan
S
Wang-Gohrke
Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network, Duarte California 91010, USA.
Jeffrey N
JN
Weitzel
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda Maryland 20892, USA.
Nicolas
N
Wentzensen
Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford California 94305, USA.
Alice S
AS
Whittemore
Multidisciplinary Breast Center, Department of General Medical Oncology, University Hospitals Leuven, B-3000 Leuven, Belgium.
Hans
H
Wildiers
Laboratory of Cancer Genetics and Tumour Biology, Northern Finland Laboratory Centre NordLab, FI-90014 Oulu, Finland.|Laboratory of Cancer Genetics and Tumour Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, FI-90014 Oulu, Finland.
Robert
R
Winqvist
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Anna H
AH
Wu
Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research 'Demokritos', Athens 153 10, Greece.
Drakoulis
D
Yannoukakos
Cancer Research Initiatives Foundation, Sime Darby Medical Centre, 47500 Subang Jaya, Malaysia.|University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, 59100 Kuala Lumpur, Malaysia.
Sook-Yee
SY
Yoon
Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, 114 Taiwan.
Jyh-Cherng
JC
Yu
Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
Wei
W
Zheng
Shanghai Center for Disease Control and Prevention, Shanghai, China.
Ying
Y
Zheng
QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia.
Kum Kum
KK
Khanna
Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Québec G1V 4G2, Canada.
Jacques
J
Simard
Cancer Epidemiology Program, Division of Population Sciences, H. Lee Moffitt Cancer Center &Research Institute, Tampa, Florida 33612, USA.
Alvaro N
AN
Monteiro
QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia.
Juliet D
JD
French
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55902, USA.|Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Fergus J
FJ
Couch
Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
Matthew L
ML
Freedman
Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.|Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Douglas F
DF
Easton
Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Alison M
AM
Dunning
Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Paul D
PD
Pharoah
QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia.
Stacey L
SL
Edwards
QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia.
Georgia
G
Chenevix-Trench
Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Antonis C
AC
Antoniou
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Simon A
SA
Gayther
D000483:Alleles; D044466:Asian People / Q000235:genetics; D044383:Black People / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D010051:Ovarian Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
D012333:RNA, Messenger