The PDRG1 is an oncogene in lung cancer cells, promoting radioresistance via the ATM-P53 signaling pathway.
PDRG1, is short for P53 and DNA damage-regulated gene, which have been found over 10 years. Although severe studies have described the roles of PDRG1 separately in many kinds of tumors, how to act as an oncogene are unclear. To better verify the function of PDRG1 in lung cancer, both loss-function and gain-function of PDRG1 studies based on two human lung cancer lines were performed. Following the transfection of PDRG1, both A549 and 95-D cells showed significant changes in cell viability, the expression of some protein and apoptosis, which were all implied the PDRG1 is an oncogene. Another interesting finding is PDRG1 could promote radioresistance involved the ATM-p53 signaling pathway in lung cancer. If we combine radiotherapy with gene-targeted therapy together effectively, predominant effect may be acquired, which is a huge milestone in clinical cure about lung cancer.
Department of Cardiothoracic Surgery, First Affiliated Hospital of Soochow University, Suzhou, 215006, China. Electronic address: 114015615@qq.com.
Zheng
Z
Tao
Department of Cardiothoracic Surgery, First Affiliated Hospital of Soochow University, Suzhou, 215006, China. Electronic address: chenshaomu@suda.edu.cn.
Shaomu
S
Chen
Department of Cardiothoracic Surgery, First Affiliated Hospital of Soochow University, Suzhou, 215006, China. Electronic address: 844023585@qq.com.
Guocai
G
Mao
Department of Cardiothoracic Surgery, First Affiliated Hospital of Soochow University, Suzhou, 215006, China. Electronic address: 1036095832@qq.com.
Haifeng
H
Xia
Department of Cardiothoracic Surgery, First Affiliated Hospital of Soochow University, Suzhou, 215006, China. Electronic address: 15312180734@163.com.
Haitao
H
Huang
Department of Cardiothoracic Surgery, First Affiliated Hospital of Soochow University, Suzhou, 215006, China. Electronic address: mahaitaosuzhou@126.com.
Haitao
H
Ma
D000818:Animals; D064007:Ataxia Telangiectasia Mutated Proteins / Q000235:genetics* / Q000528:radiation effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000235:genetics / Q000528:radiation effects; D004268:DNA-Binding Proteins / Q000008:administration & dosage / Q000235:genetics* / Q000528:radiation effects; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000532:radiotherapy; D051379:Mice; D008819:Mice, Nude; D009857:Oncogenes / Q000235:genetics* / Q000528:radiation effects; D011836:Radiation Tolerance / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics / Q000528:radiation effects; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000528:radiation effects
D004268:DNA-Binding Proteins; C478985:PDRG1 protein, human; D016159:Tumor Suppressor Protein p53; C576324:ATM protein, human; D064007:Ataxia Telangiectasia Mutated Proteins
Cell apoposis; Cell proliferation; Irradiation; Lung cancer cells; PDRG1