Estimated Cerebrospina Fluid Pressure and the 5-Year Incidence of Primary Open-Angle Glaucoma in a Chinese Population.
OBJECTIVE
We aim to assess the longitudinal association between baseline estimated cerebrospinal fluid pressure (CSFP) and 5-year incident primary open angle glaucoma (POAG) in a population-based sample of Bai Chinese living in rural China.


METHODS
Among the 2133 Bai Chinese aged 50 years or older who had participated in the baseline examination of the Yunnan Minority Eye Study, 1520 (71.3%) attended the follow-up examination after five years and 1485 were at risk of developing POAG. Participants underwent comprehensive ophthalmic examinations at both baseline and follow-up surveys. CSFP in mmHg was estimated as 0.55 × body mass index (kg/m2) + 0.16 × diastolic blood pressure (mmHg)-0.18 × age (years)-1.91. Glaucoma was defined using the International Society of Geographical and Epidemiological Ophthalmology Classification criteria. Multivariate logistic regression models were established to determine the association between baseline CSFP and incident POAG.


RESULTS
After a mean follow-up time of 5 years, 19 new cases of POAG were detected, with an incidence rate of 1.3% (95% confidence interval, 0.7-1.9%). In multivariate logistic regression analysis, after adjusting for age, gender, education, intraocular pressure, central corneal thickness, hypertension and diabetes, no significant associations, nor any trends, were evident between baseline estimated CSFP and incident POAG. The association between estimated CSFP per mmHg increase in baseline and 5-year incidence of POAG was also non-significant, with adjusted relative risk of 0.96 (P = 0.11) in multivariate analysis.


CONCLUSIONS
This longitudinal cohort study does not support previously observed cross-sectional association between estimated CSFP and POAG in population-based studies.
Department of Ophthalmology, the First Hospital of Kunming, Kunming, China.
Lan
L
Li
Affiliated Hospital of Dali University, Dali, China.
Cairui
C
Li
Department of Ophthalmology, the First Affiliated Hospital of Kunming Medical University, Kunming, China.
Hua
H
Zhong
Department of Ophthalmology, the First Affiliated Hospital of Kunming Medical University, Kunming, China.
Yijin
Y
Tao
Department of Ophthalmology, the First Affiliated Hospital of Kunming Medical University, Kunming, China.
Yuansheng
Y
Yuan
Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Suzhou, China.
Chen-Wei
CW
Pan
D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D015170:Cerebrospinal Fluid Pressure / Q000502:physiology*; D002681:China / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000453:epidemiology* / Q000503:physiopathology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged