Prognostic Value of Late Gadolinium Enhancement in Nonischemic Cardiomyopathy.
The purpose of this study was to determine the prognostic value of late gadolinium enhancement seen on cardiac magnetic resonance (CMR) imaging in patients with nonischemic cardiomyopathy (NICMP). Patients with NICMP are at increased risk for cardiovascular events and death. The presence of late gadolinium enhancement (LGE) in CMR may be associated with a poor prognosis, but its significance is still under investigation. We retrospectively studied 105 consecutive patients with NICMP and left ventricular ejection fraction (LVEF) ≤40% referred for CMR. The cohort was analyzed for the presence of LGE and left and right ventricular functional parameters. Patients were followed for the composite end point of hospitalization for congestive heart failure, appropriate implantable cardioverter-defibrillator therapy, or all-cause mortality. LGE was observed in 68% (n = 71) of the cohort. Both groups were similar in age, LVEF and LV end-diastolic volume. The LGE+ patients were more often men and had larger right ventricular volumes. At a mean follow-up of 806 ± 582 days, there were 26 patients (23 in the LGE+ group) who reached the primary end point. Event-free survival was significantly worse for the LGE+ patients. After adjusting for traditional risk factors (age, gender, and LVEF), patients with LGE had an increased risk of experiencing the primary end point (hazard ratio 4.47, 95% CIs 1.27 to 15.74, p = 0.02). The presence of LGE in patients with NICMP strongly predicts the occurrence of adverse events. In conclusion, this may be important in risk stratification and management.
Department of Medicine, Winthrop University Hospital, Mineola, New York.
Juan
J
Gaztanaga
Department of Medicine, Winthrop University Hospital, Mineola, New York.
Vijayapraveena
V
Paruchuri
Department of Medicine, Mount Sinai School of Medicine, New York, New York.
Elliott
E
Elias
Department of Medicine, Mount Sinai School of Medicine, New York, New York.
Jonathan
J
Wilner
Department of Medicine, Winthrop University Hospital, Mineola, New York.
Shahidul
S
Islam
Department of Medicine, The Medical City, Pasig City, Philippines.
Simonette
S
Sawit
Department of Medicine, University of Miami Hospital, Miami, Florida.
Juan
J
Viles-Gonzalez
Department of Medicine, Mount Sinai School of Medicine, New York, New York.
Javier
J
Sanz
Department of Medicine, Montefiore-Einstein Center for Heart and Vascular Care, Albert Einstein College of Medicine, Bronx, New York. Electronic address: mariogar@montefiore.org.
Mario J
MJ
Garcia
D000328:Adult; D000368:Aged; D009202:Cardiomyopathies / Q000000981:diagnostic imaging* / Q000453:epidemiology; D015331:Cohort Studies; D003287:Contrast Media; D017147:Defibrillators, Implantable; D005260:Female; D019786:Gadolinium DTPA; D006333:Heart Failure / Q000453:epidemiology; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008279:Magnetic Resonance Imaging; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D013318:Stroke Volume; D017180:Tachycardia, Ventricular / Q000453:epidemiology; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000453:epidemiology; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging* / Q000453:epidemiology; D014693:Ventricular Fibrillation / Q000453:epidemiology
D003287:Contrast Media; D019786:Gadolinium DTPA