Bout-associated intrinsic functional network changes in cluster headache: A longitudinal resting-state functional MRI study.
Background Previous imaging studies on the pathogenesis of cluster headache (CH) have implicated the hypothalamus and multiple brain networks. However, very little is known regarding dynamic bout-associated, large-scale resting state functional network changes related to CH. Methods Resting-state functional magnetic resonance imaging data were obtained from CH patients and matched controls. Data were analyzed using independent component analysis for exploratory assessment of the changes in intrinsic brain networks and their relationship between in-bout and out-of-bout periods, as well as correlations with clinical observations. Results Compared to healthy controls, CH patients had functional connectivity (FC) changes in the temporal, frontal, salience, default mode, somatosensory, dorsal attention, and visual networks, independent of bout period. Compared to out-of-bout scans, in-bout scans showed altered FC in the frontal and dorsal attention networks. Lower frontal network FC correlated with longer duration of CH. Conclusions The present findings suggest that episodic CH with dynamic bout period shifts may involve bout-associated FC changes in multiple discrete cortical areas within networks outside traditional pain processing areas. Dynamic changes in FC in frontal and dorsal attention networks between bout periods could be important for understanding episodic CH pathophysiology.
1 Brain Research Center, National Yang-Ming University, Taiwan.
Kun-Hsien
KH
Chou
2 Departments of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taiwan.
Fu-Chi
FC
Yang
3 Department of Neurology, National Yang-Ming University, Taiwan.|4 Department of Neurology, Taipei Veterans' General Hospital, Taiwan.
Jong-Ling
JL
Fuh
5 Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taiwan.
Chen-Yuan
CY
Kuo
5 Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taiwan.
Yi-Hsin
YH
Wang
6 Department of Radiology, National Yang-Ming University, Taiwan.|7 Department of Radiology, Taipei, Veterans' General Hospital, Taiwan.
Jiing-Feng
JF
Lirng
1 Brain Research Center, National Yang-Ming University, Taiwan.|3 Department of Neurology, National Yang-Ming University, Taiwan.|4 Department of Neurology, Taipei Veterans' General Hospital, Taiwan.|8 Institute of Brain Science, National Yang-Ming University, Taiwan.
Yung-Yang
YY
Lin
1 Brain Research Center, National Yang-Ming University, Taiwan.|3 Department of Neurology, National Yang-Ming University, Taiwan.|4 Department of Neurology, Taipei Veterans' General Hospital, Taiwan.|8 Institute of Brain Science, National Yang-Ming University, Taiwan.
Shuu-Jiun
SJ
Wang
1 Brain Research Center, National Yang-Ming University, Taiwan.|5 Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taiwan.|8 Institute of Brain Science, National Yang-Ming University, Taiwan.|9 Institute of Neuroscience, National Yang-Ming University, Taiwan.
Ching-Po
CP
Lin
D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology; D003027:Cluster Headache / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009415:Nerve Net / Q000000981:diagnostic imaging* / Q000503:physiopathology*
Bout period; Cluster headache; functional connectivity; hypothalamus; independent component analysis