Interaction of MSC with tumor cells.
Tumor development and tumor progression is not only determined by the corresponding tumor cells but also by the tumor microenvironment. This includes an orchestrated network of interacting cell types (e.g. immune cells, endothelial cells, fibroblasts, and mesenchymal stroma/stem cells (MSC)) via the extracellular matrix and soluble factors such as cytokines, chemokines, growth factors and various metabolites. Cell populations of the tumor microenvironment can interact directly and indirectly with cancer cells by mutually altering properties and functions of the involved partners. Particularly, mesenchymal stroma/stem cells (MSC) play an important role during carcinogenesis exhibiting different types of intercellular communication. Accordingly, this work focusses on diverse mechanisms of interaction between MSC and cancer cells. Moreover, some functional changes and consequences for both cell types are summarized which can eventually result in the establishment of a carcinoma stem cell niche (CSCN) or the generation of new tumor cell populations by MSC-tumor cell fusion.
Biochemistry and Tumor Biology Lab, Department of Obstetrics and Gynecology, Hannover Medical School, Carl-Neuberg-Str. 1, D, 30625, Hannover, Germany.
Catharina
C
Melzer
Biochemistry and Tumor Biology Lab, Department of Obstetrics and Gynecology, Hannover Medical School, Carl-Neuberg-Str. 1, D, 30625, Hannover, Germany.|Tongji Hospital Affiliated Tongji University, Shanghai, China.
Yuanyuan
Y
Yang
Biochemistry and Tumor Biology Lab, Department of Obstetrics and Gynecology, Hannover Medical School, Carl-Neuberg-Str. 1, D, 30625, Hannover, Germany. hass.ralf@mh-hannover.de.
Ralf
0000-0002-2481-7547
R
Hass
D000818:Animals; D002450:Cell Communication; D000067128:Extracellular Vesicles / Q000378:metabolism; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism*; D015398:Signal Transduction; D059016:Tumor Microenvironment
Cell fusion; Cellular interaction; MSC; Mesenchymal stroma/stem cells; Tumor cell signaling; Tumor microenvironment