Association between ABCB1 polymorphisms and haplotypes and Alzheimer's disease: a meta-analysis.
Although several epidemiological studies have investigated the association between ATP-binding cassette subfamily B member 1 (ABCB1) gene polymorphisms and Alzheimer's disease (AD) susceptibility, controversial results exist. Here, we performed a meta-analysis to assess whether ABCB1 polymorphisms 3435C > T (rs1045642), 2677G > T/A (rs2032582), 1236C > T (rs1128503) and haplotypes were associated with AD risk. Nine independent publications were included and analyzed. Crude odds ratio (OR) and 95% confidence interval (CI) were applied to investigate the strength of the association. Sensitivity analysis was conducted to measure the robustness of our analysis. A funnel plot and trim and fill method were used to test and adjust for publication bias. The results showed a significant association between the 3435C > T single nucleotide polymorphism (SNP) and AD susceptibility (CT vs. CC: OR = 1.24, 95% CI = 1.06-1.45, P = 0.01; CT + TT vs. CC: OR = 1.21, 95% CI = 1.04-1.41, P = 0.01) in the total population, as well as in Caucasian subgroup. The 2677G > T/A SNP was related to a decreased AD risk in Caucasian subgroup (TT + TA + AA vs. GT + GA + GG: OR = 0.68, 95% CI = 0.47-0.98, P = 0.04). Moreover, the ABCB1 haplotype analysis showed that the 1236T/2677T/3435C haplotype was associated with a higher risk of AD (OR = 1.99, 95% CI = 1.24-3.18, P = 0.00). Our results suggest that the ABCB1 3435C > T SNP, the 2677G > T/A SNP and 1236T/2677T/3435C haplotype are significantly associated with AD susceptibility.
School of Pharmacy, Department of Pharmacology, China Medical University, Shenyang, Liaoning 110122, China.
Xin
X
Zhong
School of Pharmacy, Department of Pharmacology, China Medical University, Shenyang, Liaoning 110122, China.
Ming-Yan
MY
Liu
Department of Neurology, the Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, China.
Xiao-Hong
XH
Sun
School of Pharmacy, Department of Pharmacology, China Medical University, Shenyang, Liaoning 110122, China.
Min-Jie
MJ
Wei
D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics; D000544:Alzheimer Disease / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D020641:Polymorphism, Single Nucleotide
C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B