The Yin-Yang Principle of Endoplasmic Reticulum Stress and oral cancer.
The endoplasmic reticulum (ER) is an organelle, which performs several cellular functions and is thus an important site for maintaining cellular homeostasis. Sometimes pathways within the ER are disturbed, especially those regulating the protein folding, gene expression, cellular metabolism, and calcium signaling, and is called an "ER stress."(1) The accumulation of unfolded, misfolded, or damaged proteins can irreparably damage cellular functions and can pose a severe threat to the existence of the cell. Under such circumstances, ER functions become overwhelmed triggering the homeostatic "ER stress response" or "unfolded protein response" (UPR).(2).
Associate Professor, Department of Oral Pathology and Microbiology, D. Y. Patil Dental College & Hospital, Pune, Maharashtra, India, India, Phone: +919823871462, e-mail: gargi14@gmail.com.
Gargi S
GS
Sarode
Department of Oral Pathology and Microbiology, D. Y. Patil Dental College & Hospital, Pune, Maharashtra, India.
Sachin C
SC
Sarode
Department of Diagnostic Sciences, Division of Oral Pathology College of Dentistry, Jazan University, Jazan, Kingdom of Saudi Arabia.
Shankargouda
S
Patil
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D020013:Calcium Signaling / Q000502:physiology; D049109:Cell Proliferation / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D059865:Endoplasmic Reticulum Stress / Q000502:physiology*; D015870:Gene Expression / Q000502:physiology; D006801:Humans; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000503:physiopathology*; D017510:Protein Folding; D043562:Receptors, G-Protein-Coupled / Q000502:physiology; D051742:Transcription Factor CHOP / Q000502:physiology
D043562:Receptors, G-Protein-Coupled; D051742:Transcription Factor CHOP