Laponite as carrier for controlled in vitro delivery of dexamethasone in vitreous humor models.
Laponite clay is able to retain dexamethasone by simple physisorption, presumably accomplished by hydrogen bonding formation and/or complexation with sodium counterions, as shown by solid state NMR. The physisorption can be somehow modulated by changing the solvent in the adsorption process. This simple system is able to deliver dexamethasone in a controlled manner to solutions used as models for vitreous humor. The proven biocompatibility of laponite as well as its transparency in the gel state, together with the simplicity of the preparation method, makes this system suitable for future in vivo tests of ophthalmic treatment.
Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), Facultad de Ciencias, Universidad de Zaragoza-CSIC, C/ Pedro Cerbuna 12, E-50009 Zaragoza, Spain. Electronic address: jmfraile@unizar.es.
José M
JM
Fraile
Departamento de Oftalmología, Hospital Universitario Miguel Servet, C/ Padre Arrupe, Edificio Consultas Externas, E-50009 Zaragoza, Spain; Instituto de Investigación Sanitaria Aragón (IIS-Aragón), Universidad de Zaragoza, Facultad de Medicina, C/ Domingo Miral s/n, E-50009 Zaragoza, Spain.
Elena
E
Garcia-Martin
Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), Facultad de Ciencias, Universidad de Zaragoza-CSIC, C/ Pedro Cerbuna 12, E-50009 Zaragoza, Spain.
Cristina
C
Gil
Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), Facultad de Ciencias, Universidad de Zaragoza-CSIC, C/ Pedro Cerbuna 12, E-50009 Zaragoza, Spain. Electronic address: mayoral@unizar.es.
José A
JA
Mayoral
Departamento de Oftalmología, Hospital Universitario Miguel Servet, C/ Padre Arrupe, Edificio Consultas Externas, E-50009 Zaragoza, Spain; Instituto de Investigación Sanitaria Aragón (IIS-Aragón), Universidad de Zaragoza, Facultad de Medicina, C/ Domingo Miral s/n, E-50009 Zaragoza, Spain.
Luis E
LE
Pablo
Departamento de Oftalmología, Hospital Universitario Miguel Servet, C/ Padre Arrupe, Edificio Consultas Externas, E-50009 Zaragoza, Spain; Instituto de Investigación Sanitaria Aragón (IIS-Aragón), Universidad de Zaragoza, Facultad de Medicina, C/ Domingo Miral s/n, E-50009 Zaragoza, Spain.
Vicente
V
Polo
Departamento de Oftalmología, Hospital Universitario Miguel Servet, C/ Padre Arrupe, Edificio Consultas Externas, E-50009 Zaragoza, Spain; Instituto de Investigación Sanitaria Aragón (IIS-Aragón), Universidad de Zaragoza, Facultad de Medicina, C/ Domingo Miral s/n, E-50009 Zaragoza, Spain.
Esther
E
Prieto
Laboratorio de Cromatografía y Espectroscopia, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), Facultad de Ciencias, Universidad de Zaragoza-CSIC, C/ Pedro Cerbuna 12, E-50009 Zaragoza, Spain.
Eugenio
E
Vispe
D000327:Adsorption; D000538:Aluminum Silicates; D001672:Biocompatible Materials / Q000737:chemistry; D000077215:Clay; D003907:Dexamethasone / Q000008:administration & dosage / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D017640:Silicates / Q000737:chemistry*; D012964:Sodium / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D055672:Static Electricity; D014822:Vitreous Body / Q000378:metabolism*
D000538:Aluminum Silicates; D001672:Biocompatible Materials; D004337:Drug Carriers; D017640:Silicates; D012997:Solvents; D003907:Dexamethasone; D012964:Sodium; C524813:laponite; D000077215:Clay
Controlled delivery; Corticosteroids; Dexamethasone; Laponite; Vitreous humor