CO2 exposure as translational cross-species experimental model for panic.
The current diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders are being challenged by the heterogeneity and the symptom overlap of psychiatric disorders. Therefore, a framework toward a more etiology-based classification has been initiated by the US National Institute of Mental Health, the research domain criteria project. The basic neurobiology of human psychiatric disorders is often studied in rodent models. However, the differences in outcome measurements hamper the translation of knowledge. Here, we aimed to present a translational panic model by using the same stimulus and by quantitatively comparing the same outcome measurements in rodents, healthy human subjects and panic disorder patients within one large project. We measured the behavioral-emotional and bodily response to CO2 exposure in all three samples, allowing for a reliable cross-species comparison. We show that CO2 exposure causes a robust fear response in terms of behavior in mice and panic symptom ratings in healthy volunteers and panic disorder patients. To improve comparability, we next assessed the respiratory and cardiovascular response to CO2, demonstrating corresponding respiratory and cardiovascular effects across both species. This project bridges the gap between basic and human research to improve the translation of knowledge between these disciplines. This will allow significant progress in unraveling the etiological basis of panic disorder and will be highly beneficial for refining the diagnostic categories as well as treatment strategies.
Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands.|School for Mental Health and Neuroscience, Maastricht University, European Graduate School of Neuroscience, Maastricht, The Netherlands.|Department of Neurology, Yale University, New Haven, CT, USA.
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Leibold
Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands.|School for Mental Health and Neuroscience, Maastricht University, European Graduate School of Neuroscience, Maastricht, The Netherlands.|Division of Molecular Psychiatry, Laboratory of Translational Neuroscience, Center of Mental Health, University of Wuerzburg, Wuerzburg, Germany.
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van den Hove
Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands.|School for Mental Health and Neuroscience, Maastricht University, European Graduate School of Neuroscience, Maastricht, The Netherlands.
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0000-0003-3463-4063
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Viechtbauer
Department of Neurology, Yale University, New Haven, CT, USA.|Department of Neurology, University of Iowa, Iowa City, IA, USA.
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Buchanan
Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands.|School for Mental Health and Neuroscience, Maastricht University, European Graduate School of Neuroscience, Maastricht, The Netherlands.
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Goossens
Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands.|School for Mental Health and Neuroscience, Maastricht University, European Graduate School of Neuroscience, Maastricht, The Netherlands.
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Lange
Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands.|School for Mental Health and Neuroscience, Maastricht University, European Graduate School of Neuroscience, Maastricht, The Netherlands.
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Knuts
Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands.|School for Mental Health and Neuroscience, Maastricht University, European Graduate School of Neuroscience, Maastricht, The Netherlands.|Division of Molecular Psychiatry, Laboratory of Translational Neuroscience, Center of Mental Health, University of Wuerzburg, Wuerzburg, Germany.
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Lesch
Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands.|School for Mental Health and Neuroscience, Maastricht University, European Graduate School of Neuroscience, Maastricht, The Netherlands.
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Steinbusch
Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands.|School for Mental Health and Neuroscience, Maastricht University, European Graduate School of Neuroscience, Maastricht, The Netherlands.|Center for the Psychology of Learning and Experimental Psychopathology, Department of Psychology, University of Leuven, Tiensestraat, Leuven, Belgium.
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Schruers
D000293:Adolescent; D000328:Adult; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D019296:Capnography; D002245:Carbon Dioxide / Q000009:adverse effects / Q000494:pharmacology*; D004195:Disease Models, Animal; D005239:Fear / Q000187:drug effects*; D005260:Female; D064368:Healthy Volunteers; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D051379:Mice; D008875:Middle Aged; D010200:Panic / Q000187:drug effects*; D016584:Panic Disorder / Q000503:physiopathology / Q000523:psychology*; D055815:Young Adult
D002245:Carbon Dioxide