Recent Advances in the Synthesis of SCF2H- and SCF2FG-Containing Molecules.
In recent years, much interest has been paid to difluoromethylthiolated molecules as the "SCF2" moiety is a key motif in drug and agrochemical research. Consequently, the development of versatile strategies for the selective synthesis of SCF2H- and SCF2FG-containing molecules (FG=functional group) has attracted a lot of attention and inspired the scientific community to design new tools. This Minireview highlights the major progress made in this field. Particularly, methodologies developed for the difluoromethylation of sulfur-containing molecules and the direct construction of C-SCF2bonds in various classes of compounds are showcased and discussed.
Normandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000, Rouen, France.
Heng-Ying
http://orcid.org/0000-0003-0726-524X
HY
Xiong
Normandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000, Rouen, France.
Xavier
http://orcid.org/0000-0002-4598-7895
X
Pannecoucke
Normandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000, Rouen, France.
Tatiana
http://orcid.org/0000-0003-4877-5270
T
Besset
difluoromethylation; difluoromethylthiolation; fluorine; sulfur; synthetic methods