Increased circulating procoagulant and anticoagulant factors as TF and TFPI according to severity or infecting serotypes in human dengue infection.
Tissue Factor (TF) is the initiator of coagulation and Tissue Factor Inhibitor (TFPI) is the physiological inhibitor of the TF/FVIIa complex. Circulating levels of TF and TFPI were quantified in dengue patients and the relationships with disease severity and infecting serotype analysed. A significant decrease in TF and TPFI plasma levels was observed in mild DF patients compared with severe dengue. Furthermore, both factors were associated with haemorrhagic manifestations. Finally, TF levels were significantly increased in DENV-1/2 infected patients as compared with DENV-4. These findings suggest that activation of TF-pathway is an important component of DENV -related coagulation disorders.
Laboratory of Viral Immunology, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil. Electronic address: elzinandes@ioc.fiocruz.br.
Elzinandes
E
Leal de Azeredo
Laboratory of Viral Immunology, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil.
Victor Edgar Fiestas
VE
Solórzano
Laboratory of Viral Immunology, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil.
Débora Batista
DB
de Oliveira
Laboratory of Viral Immunology, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil.
Cintia Ferreira
CF
Marinho
Referral Centre for Dengue, Campos de Goytacazes, Brazil.
Luiz José
LJ
de Souza
Department of Clinical Medicine, Universidade Federal do Mato Grosso do Sul, Campo Grande, Brazil.
Rivaldo Venâncio
RV
da Cunha
Rio-Laranjeiras Hospital, Gaffrée Guinle University Hospital (The Federal University of Rio de Janeiro), Rio de Janeiro, Brazil; Pedro Ernesto University Hospital (The State University of Rio de Janeiro), Rio de Janeiro, Brazil.
Paulo Vieira
PV
Damasco
Laboratory of Viral Immunology, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil.
Claire Fernandes
CF
Kubelka
Laboratory of Viral Immunology, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil.
Luzia Maria
LM
de-Oliveira-Pinto
D000328:Adult; D003715:Dengue / Q000473:pathology*; D003716:Dengue Virus / Q000145:classification*; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D065288:Serogroup; D012720:Severity of Illness Index; D013925:Thromboplastin / Q000032:analysis*; D055815:Young Adult
D008074:Lipoproteins; C051928:lipoprotein-associated coagulation inhibitor; D013925:Thromboplastin
Dengue; TF; TFPI