Chitosan: An efficient biomacromolecule support for synergic catalyzing of Hantzsch esters by CuSO4.
The synergic effect of the chitosan biomacromolecule support for catalyzing of Hantzsch esters formation by CuSO4has been demonstrated for one-pot and efficient pseudo-four-component reaction to afford a wide range of 1,4-dihydropyridine (DHP) or polyhydroquinoline (PHQ) derivatives. The desired products were simply prepared from different aldehydes, β-dicarbonyls and ammonium acetate in the presence of a low loading of chitosan supported copper(II) sulfate (CSCS) in EtOH under reflux conditions. The biodegradable CSCS catalyst was characterized by field emission scanning electron microscopy (FESEM) and energy-dispersive X-ray spectroscopy analysis (EDX) methods as well as coupled plasma-atomic emission (ICP-AE) and FT-IR spectroscopy. The CSCS catalyst is recyclable and reused four times without significant loss of its activity.
Pharmaceutical and Biologically-Active Compounds Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran. Electronic address: mdekamin@iust.ac.ir.
Mohammad G
MG
Dekamin
Pharmaceutical and Biologically-Active Compounds Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran.
Elham
E
Kazemi
Pharmaceutical and Biologically-Active Compounds Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran.
Zahra
Z
Karimi
Pharmaceutical and Biologically-Active Compounds Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran.
Maryam
M
Mohammadalipoor
Pharmaceutical and Biologically-Active Compounds Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran.
M Reza
MR
Naimi-Jamal
D002384:Catalysis; D048271:Chitosan / Q000737:chemistry*; D019327:Copper Sulfate / Q000737:chemistry*
D048271:Chitosan; D019327:Copper Sulfate
Biodegradable heterogeneous catalysis; Chitosan supported copper(II) sulfate (CSCS); Green chemistry; Hantzsch esters; Multicomponent reactions (MCRs)