Polyethylene glycol plus ascorbic acid for bowel preparation in chronic kidney disease.
The safety of polyethylene glycol plus ascorbic acid has not been fully investigated in patients with renal insufficiency. High-dose ascorbic acid could induce hyperoxaluria, thereby causing tubule-interstitial nephritis and renal failure. This study aims to evaluate the safety and efficacy of polyethylene glycol plus ascorbic acid in patients with chronic kidney disease.We retrospectively reviewed prospectively collected data on colonoscopy in patients with impaired renal function. Patients were divided into 2 groups: 2 L polyethylene glycol plus ascorbic acid (n = 61) and 4 L polyethylene glycol (n = 80). The safety of the 2 groups was compared by assessing the differences in laboratory findings before and after bowel cleansing.The laboratory findings were not significantly different before and after the administration of 2 L polyethylene glycol plus ascorbic acid or 4 L polyethylene glycol. In both groups, the estimated glomerular filtration rate was not influenced by the administration of the bowel-cleansing agent. Patients' reports on tolerance and acceptability were better in the 2 L polyethylene glycol plus ascorbic acid group than in the 4 L polyethylene glycol group.The 2 L polyethylene glycol plus ascorbic acid solution is a safe choice for bowel preparation before colonoscopy in patients with impaired renal function.
Division of Gastroenterology and Hepatology Division of Nephrology, Department of Internal Medicine, Korea University College of Medicine, Seongbuk-gu, Seoul, 02841, Korea.
Jae Min
JM
Lee
Bora
B
Keum
In Kyung
IK
Yoo
Seung Han
SH
Kim
Hyuk Soon
HS
Choi
Eun Sun
ES
Kim
Yeon Seok
YS
Seo
Yoon Tae
YT
Jeen
Hoon Jai
HJ
Chun
Hong Sik
HS
Lee
Soon Ho
SH
Um
Chang Duck
CD
Kim
Myung Gyu
MG
Kim
Sang Kyung
SK
Jo
D000368:Aged; D001205:Ascorbic Acid; D002400:Cathartics; D003113:Colonoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols; D051436:Renal Insufficiency, Chronic; D012189:Retrospective Studies
D002400:Cathartics; D011092:Polyethylene Glycols; D001205:Ascorbic Acid