Similar impact of multiple sclerosis and migraine on sexual function in women : Is the multiple sclerosis impact scale questionnaire useful?
BACKGROUND
Sexuality is an integral part of overall health but the impact of neurological diseases on sexual function still receives too little attention.


OBJECTIVE
The aim of this case control study was to compare frequencies and characteristics of sexual dysfunction in women with stable relapsing-remitting multiple sclerosis (MS) and migraine.


METHODS
Sexually active women aged 18-50 years were recruited at the MS and headache outpatient clinics of a university hospital and asked to complete questionnaires on sexual function using the multiple sclerosis intimacy and sexuality questionnaire (MSISQ-19) adapted for patients with migraine, depression using the Beck depression inventory (BDI-II) and quality of life using the short form-36 questionnaire (SF-36).


RESULTS
At least one symptom of sexual dysfunction was "almost always" or "always" present in 35.7 % of 42 patients with MS and in 22.6 % of 30 patients with migraine (p = 0.3). The MSISQ-19 total score did not differ between the two groups (31.6 ± 10.8 vs. 28.2 ± 11.6, respectively, p = 0.2). Sexual dysfunction was categorized as primary, secondary and tertiary in 66.7 %, 40 % and 33.3 % of MS patients and in 57.1 % (p = 0.7), 71.4 % (p = 0.2) and 71.4 % (p = 0.1) of migraine patients, respectively. Depressive symptoms were more common in women with sexual dysfunction than in those without both in MS (p = 0.001) and migraine (p = 0.006). The SF-36 showed decreasing quality of life with increasing MSISQ-19 sum scores (mental subscale p < 0.001 and physical subscale p = 0.04).


CONCLUSIONS
Sexual dysfunction is a major problem both in women with MS and in women with migraine and is strongly associated with comorbid depression and impaired quality of life. Thus, categorizing sexuality as done by MSISQ-19 is limited by its complex biopsychosocial interactions.
Medical University of Vienna, Vienna, Austria. sabine.salhofer-polanyi@meduniwien.ac.at.|Department of Neurology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria. sabine.salhofer-polanyi@meduniwien.ac.at.
Sabine
S
Salhofer-Polanyi
Medical University of Vienna, Vienna, Austria.
Christian
C
Wöber
Medical University of Vienna, Vienna, Austria.
Ricarda
R
Prohazka
Medical University of Vienna, Vienna, Austria.
Assunta
A
Dal-Bianco
Medical University of Vienna, Vienna, Austria.
Barbara
B
Bajer-Kornek
Medical University of Vienna, Vienna, Austria.
Karin
K
Zebenholzer
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D015984:Causality; D015897:Comorbidity; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D008881:Migraine Disorders / Q000175:diagnosis / Q000453:epidemiology*; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000453:epidemiology*; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012735:Sexual Dysfunction, Physiological / Q000175:diagnosis* / Q000453:epidemiology*; D018434:Sickness Impact Profile; D011795:Surveys and Questionnaires; D016387:Women's Health / Q000706:statistics & numerical data; D055815:Young Adult
Depression; Migraine; Multiple sclerosis; Quality of life; Sexual dysfunction