The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.
To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure-associated loci, of which 17 were new; 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target organ damage in multiple tissues but with minor effects in the kidney. Our findings expand current knowledge of blood pressure-related pathways and highlight tissues beyond the classical renal system in blood pressure regulation.
Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.|Cardiology, Department of Medicine, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland.
Georg B
GB
Ehret
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
Teresa
T
Ferreira
Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave. East, Boston, MA 02215, USA.|Harvard Medical School, Boston, MA 02115, USA.
Daniel I
DI
Chasman
Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.|Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Anne U
AU
Jackson
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Ellen M
EM
Schmidt
Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.|GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, UK.
Toby
T
Johnson
deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Gudmar
G
Thorleifsson
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Jian'an
J
Luan
Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.
Lousie A
LA
Donnelly
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Stavroula
S
Kanoni
Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany.
Ann-Kristin
AK
Petersen
Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Vasyl
V
Pihur
Cardiovascular Research Unit, Center for Molecular Medicine L8:03, Department of Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden.|Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.
Rona J
RJ
Strawbridge
Department of Public Health and Clinical Medicine, Umeå University, Sweden.|Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, SE-205 02 Malmö, Sweden.|Department of Odontology, Umeå University, Sweden.
Dmitry
D
Shungin
Centre of Excellence for Public Health, Queens University Belfast, Grosvenor Road, Belfast BT126JP, UK.
Maria F
MF
Hughes
Laboratory of Genetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
Osorio
O
Meirelles
Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK.
Marika
M
Kaakinen
INSERM UMR970, Paris Cardiovascular Research Center PARCC, 56 rue Leblanc, 75015 Paris, France.|University Paris-Descartes, Sorbonne Paris Cité, 12 rue de l'Ecole de medicine, F-75006 Paris, France.
Nabila
N
Bouatia-Naji
National Institute for Health and Welfare, FI-00271 Helsinki, Finland.|Institute for Molecular Medicine Finland FIMM, University of Helsinki, 00290 Helsinki, Finland.
Kati
K
Kristiansson
Genetic Epidemiology Group, Dept. Epidemiology and Public Health, UCL, London, WC1E 6BT, UK.
Sonia
S
Shah
Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
Marcus E
ME
Kleber
Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA.
Xiuqing
X
Guo
Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.|Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33014, Finland.
Leo-Pekka
LP
Lyytikäinen
University of Lund, Dept Internal Medicine, Malmo, SE 20502, Sweden.|University of Verona, Dept of Internal Medicine, Verona, Italy 37134.
Cristiano
C
Fava
Uppsala University, Uppsala Clinical Research Center, SE-75185 Uppsala, Sweden.
Niclas
N
Eriksson
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
Ilja M
IM
Nolte
Dept of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77 Stockholm, Sweden.
Patrik K
PK
Magnusson
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Elias L
EL
Salfati
Second Department of Cardiology, Attikon Hospital, School of Medicine, University of Athens, Athens, Greece.
Loukianos S
LS
Rallidis
Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA.
Elizabeth
E
Theusch
Department of Cardiovascular Genetics, Institute of Cardiovascular Sciences, University College London, London WC1E 6JF, UK.
Andrew J P
AJP
Smith
Cardiovascular Research Unit, Center for Molecular Medicine L8:03, Department of Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden.
Lasse
L
Folkersen
Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.|NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, EC1M 6BQ, UK.
Kate
K
Witkowska
Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115, USA.|Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA 02115, USA.|Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA.|Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic, Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.|Department of Epidemiology Research, Statens Serum Institut, 2300, Copenhagen, Denmark.
Tune H
TH
Pers
National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.
Roby
R
Joehanes
Dept. Dev. Bio. And Genetics, Stanford University Medical Center, Stanford, CA 94305, USA.
Stuart K
SK
Kim
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Lazaros
L
Lataniotis
Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands.
Rick
R
Jansen
National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.|National Heart, Lung and Blood Institute, Cardiovascular Epidemiology and Human Genomics Branch, Bethesda, MD 20814, USA.
Andrew D
AD
Johnson
Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.|NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, EC1M 6BQ, UK.
Helen
H
Warren
Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Young Jin
YJ
Kim
Division of Translational Medicine and Human Genetics, Department of Medicine, University of Pennyslvania, USA.
Wei
W
Zhao
Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Ying
Y
Wu
Department of Preventive Medicine and Epidemiology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 60153, USA.
Bamidele O
BO
Tayo
Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Route de la Corniche 10, 1010 Lausanne, Switzerland.
Murielle
M
Bochud
HudsonAlpha Institute for Biotechnology, Huntsville, AL 35086, USA.
Devin
D
Absher
Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA.
Linda S
LS
Adair
Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam, 3015CN, The Netherlands.
Najaf
N
Amin
Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Dan E
DE
Arking
Uppsala University, Department of Medical Sciences, SE-75185 Uppsala, Sweden.
Tomas
T
Axelsson
Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy.|Centro Cardiologico Monzino, IRCCS, Milan, Italy.
Damiano
D
Baldassarre
INSERM Centre for Research in Epidemiology and Population Health, U1018, Villejuif, France University Paris-Sud, URMS 1018, Villejuif, France.
Beverley
B
Balkau
Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.
Stefania
S
Bandinelli
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.|NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, EC1M 6BQ, UK.
Michael R
MR
Barnes
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, UK.|University of Cambridge Metabolic Research Laboratories, Level 4, Institute of Metabolic Science Box 289 Addenbrookes Hospital Cambridge CB2 OQQ, UK.|NIHR Cambridge Biomedical Research Centre, Level 4, Institute of Metabolic Science Box 289 Addenbrookes Hospital Cambridge CB2 OQQ, UK.
Inês
I
Barroso
School of Life Science, University of Lincoln, Joseph Banks Laboratories, Lincoln LN6 7DL, UK.
Stephen
S
Bevan
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.
Joshua C
JC
Bis
deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Gyda
G
Bjornsdottir
Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.|Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Michael
M
Boehnke
Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, 1200 Pressler St., Suite 453E, Houston, TX 77030, USA.
Eric
E
Boerwinkle
Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Lori L
LL
Bonnycastle
Department of Biological Psychology, VU University, Amsterdam, The Netherlands.
Dorret I
DI
Boomsma
Dept of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany.
Stefan R
SR
Bornstein
The Barts Heart Centre, William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, UK.
Morris J
MJ
Brown
Nephrology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Bugnon 17, 1005 Lausanne, Switzerland.
Michel
M
Burnier
Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.|NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, EC1M 6BQ, UK.
Claudia P
CP
Cabrera
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.|Department of Cardiology, Ealing Hospital NHS Trust, Uxbridge Road, Southall, Middlesex UB1 3EU, UK.|Imperial College Healthcare NHS Trust, London, UK.
John C
JC
Chambers
National Institute of Cancer Research, National Health Research Institutes. 35 Keyan Rd., Zhunan Town, Miaoli County 350, Taiwan.
I-Shou
IS
Chang
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore.|Duke-NUS Graduate Medical School Singapore, Singapore 169857, Singapore.|Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228.
Ching-Yu
CY
Cheng
Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Peter S
PS
Chines
Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes. 35 Keyan Rd., Zhunan Town, Miaoli County 350, Taiwan.
Ren-Hua
RH
Chung
Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Francis S
FS
Collins
University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.
John M
JM
Connell
Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg 85764, Germany.|Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg 85764, Germany.
Angela
A
Döring
UMR744 Inserm-Lille2-Institut Pasteur Lille, France.
Jean
J
Dallongeville
Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.|Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, UK.|NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
John
J
Danesh
Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Ulf
U
de Faire
Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
Graciela
G
Delgado
BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, 126 University Place, Glasgow, G12 8QT, UK.
Anna F
AF
Dominiczak
Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.
Alex S F
ASF
Doney
Department of Cardiovascular Genetics, Institute of Cardiovascular Sciences, University College London, London WC1E 6JF, UK.
Fotios
F
Drenos
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, UK.
Sarah
S
Edkins
National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.|National Heart, Lung and Blood Institute, Cardiovascular Epidemiology and Human Genomics Branch, Bethesda, MD 20814, USA.
John D
JD
Eicher
Cardiovascular Epidemiology and Genetics. IMIM (Institut Hospital del Mar d'Investigacions Mèdiques), Barcelona, Spain.
Roberto
R
Elosua
Department of Immunology, Genetics and Pathology, University of Uppsala, Box 815, Biomerical center, 751 08 Uppsala, Sweden.|Science for Life Laboratory, University of Uppsala, Box 815, Biomerical center, 751 08 Uppsala, Sweden.
Stefan
S
Enroth
Institut für Integrative und Experimentelle Genomik, Universiät zu Lübeck, RatzeburgerAllee 160, 23538 Lübeck, Germany.|Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), partner site Hamburg, Kiel, Lübeck, Universität zu Lübeck, Lübeck, Germany.
Jeanette
J
Erdmann
Cardiovascular Research Unit, Center for Molecular Medicine L8:03, Department of Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden.
Per
P
Eriksson
Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.|Divisions of Endocrinology/Children's Hospital, Boston, MA 02115, USA.|Broad Institute of Harvard and MIT, Cambridge, MA 02139 USA.
Tonu
T
Esko
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.|Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, 45110, Greece.
Evangelos
E
Evangelou
Centre of Excellence for Public Health, Queens University Belfast, Grosvenor Road, Belfast BT126JP, UK.
Alun
A
Evans
Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Tove
T
Fall
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.|Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Martin
M
Farrall
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA Rotterdam, The Netherlands.
Janine F
JF
Felix
Toulouse University School of Medicine, Rangueil University Hospital, INSERM UMR1027, Toulouse, France.
Jean
J
Ferrières
Translational Gerontology Branch, National Institute on Aging, Baltimore MD, USA.
Luigi
L
Ferrucci
Institute of Molecular Medicine, University of Texas Health Science Center at Houston, TX, USA.
Myriam
M
Fornage
Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston 7, Jamaica.
Terrence
T
Forrester
Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA.
Nora
N
Franceschini
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA Rotterdam, The Netherlands.
Oscar H Franco
OHF
Duran
Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, 45110, Greece.
Anders
A
Franco-Cereceda
Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.|Synpromics Ltd, 9 Bioquarter, Little France Road, Edinburgh, EH16 4UX, Scotland.
Ross M
RM
Fraser
University of Michigan Medical School, 7220 MSRB III, Ann Arbor MI 48109, USA.
Santhi K
SK
Ganesh
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.
He
H
Gao
Cardiovascular Research Unit, Center for Molecular Medicine L8:03, Department of Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden.|Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.
Karl
K
Gertow
EPIMED Research Centre - Epidemiology and Preventive Medicine, Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy.|Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo NEUROMED, 86077 Pozzilli, Italy.
Francesco
F
Gianfagna
Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Bruna
B
Gigante
Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave. East, Boston, MA 02215, USA.
Franco
F
Giulianini
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.|Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Anuj
A
Goel
Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.|National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK.
Alison H
AH
Goodall
Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Mark O
MO
Goodarzi
Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.|Department of Nephrology, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.
Mathias
M
Gorski
Department of Medicine III, Division Pathobiochemistry, Technische Universität Dresden, Dresden, Germany.
Jürgen
J
Gräßler
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Christopher
C
Groves
Icelandic Heart Association, Kopavogur, Iceland.|Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Vilmundur
V
Gudnason
Department of Immunology, Genetics and Pathology, University of Uppsala, Box 815, Biomerical center, 751 08 Uppsala, Sweden.|Science for Life Laboratory, University of Uppsala, Box 815, Biomerical center, 751 08 Uppsala, Sweden.
Ulf
U
Gyllensten
Department of Public Health and Clinical Medicine, Umeå University, Sweden.
Göran
G
Hallmans
Institute of Clinical Medicine/Obstetrics and Gynaecology, University of Oulu, Oulu, Finland.|Medical Research Center, Oulu University Hospital, Oulu, Finland.
Anna-Liisa
AL
Hartikainen
Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Maija
M
Hassinen
National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Aki S
AS
Havulinna
Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU Scotland, UK.
Caroline
C
Hayward
UREN, INSERM U557, INRA U1125, CNAM, SMBH, Sorbonne Paris Cité, Université Paris 13, Bobigny, France.
Serge
S
Hercberg
Institute of Biomedicine, University of Oulu, Medical Research Center Oulu and Oulu University Hospital, Finland.|Biocenter Oulu, P.O.Box 5000, Aapistie 5A, FI-90014 University of Oulu, Finland.|Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland.
Karl-Heinz
KH
Herzig
Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, 39100, Italy - affiliated institute of the University of Lübeck, Germany.
Andrew A
AA
Hicks
Genetic Epidemiology Group, Dept. Epidemiology and Public Health, UCL, London, WC1E 6BT, UK.
Aroon D
AD
Hingorani
Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115, USA.|Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA 02115, USA.|Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA.|Department of Genetics, Harvard Medical School, Boston, 02115, USA.
Joel N
JN
Hirschhorn
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA Rotterdam, The Netherlands.|Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Albert
A
Hofman
HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, Norway.
Jostein
J
Holmen
HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, Norway.|St. Olav Hospital, Trondheim University Hospital, Trondheim, Norway.
Oddgeir Lingaas
OL
Holmen
Department of Biological Psychology, VU University, Amsterdam, The Netherlands.
Jouke-Jan
JJ
Hottenga
Department of Cardiovascular Genetics, Institute of Cardiovascular Sciences, University College London, London WC1E 6JF, UK.
Phil
P
Howard
Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes. 35 Keyan Rd., Zhunan Town, Miaoli County 350, Taiwan.
Chao A
CA
Hsiung
Cardiovascular Genetics Division, University of Utah School of Medicine, Salt Lake City, Utah, USA.|Department of Genetic Medicine, Weill Cornell Medical College Qatar, Doha, Qatar.
Steven C
SC
Hunt
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA Rotterdam, The Netherlands.|Department of Radiology, Erasmus MC, The Netherlands.|Department of Neurology, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA Rotterdam, The Netherlands.
M Arfan
MA
Ikram
Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany.|Hannover Unified Biobank, Hannover Medical School, Hannover 30625, Germany.|Hannover Medical School, Institute for Human Genetics, Carl-Neuberg-Strasse 1, 30625 Hanover, Germany.
Thomas
T
Illig
Kaiser Permanente, Division of Research, Oakland, CA 94612, USA.
Carlos
C
Iribarren
Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, 1200 Pressler St., Suite 453E, Houston, TX 77030, USA.|Department of Medicine, University of Washington, Seattle, Washington 98101, USA.
Richard A
RA
Jensen
Department of Clinical Physiology, Tampere University Hospital, Tampere 33521, Finland.
Mika
M
Kähönen
Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.|Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Hyun
H
Kang
Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA.|Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.|Department of Medicine, Harvard Medical School, Boston, MA, USA.|Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA.|Cardiology Division, Department of Medicine, Massachusetts General Hospital.
Sekar
S
Kathiresan
Division of Transplantation, Department of Surgery, University of Pennsylvania, PA 19104 USA.|Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, USA.
Brendan J
BJ
Keating
Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge CB2 2SR, UK.
Kay-Tee
KT
Khaw
Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Yun Kyoung
YK
Kim
Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA.
Eric
E
Kim
Genetic Epidemiology Group, Dept. Epidemiology and Public Health, UCL, London, WC1E 6BT, UK.
Mika
M
Kivimaki
Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany.|Hannover Unified Biobank, Hannover Medical School, Hannover 30625, Germany.
Norman
N
Klopp
1st Cardiology Department, Onassis Cardiac Surgery Center 356, Sygrou Ave, Athens, Greece.
Genovefa
G
Kolovou
Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Pirjo
P
Komulainen
National Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, Ducane Road, London W12 0NN, UK.|Department of Cardiology, Ealing Hospital NHS Trust, Uxbridge Road, Southall, Middlesex UB1 3EU, UK.|Imperial College Healthcare NHS Trust, London, UK.
Jaspal S
JS
Kooner
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.|Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA.|Broad Institute of Harvard and MIT, Cambridge, MA 02139 USA.
Gulum
G
Kosova
Department of Medicine, Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA.
Ronald M
RM
Krauss
MRC Unit for Lifelong Health and Ageing at UCL, London, WC1B 5JU, UK.
Diana
D
Kuh
Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.|Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Zoltan
Z
Kutalik
Department of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
Johanna
J
Kuusisto
HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, Norway.
Kirsti
K
Kvaløy
Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Finland.|Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.|Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.
Timo A
TA
Lakka
Office of Population Studies Foundation Inc., Talamban, Cebu City, 6000, Philippines.|Department of Anthropology, Sociology, and History, University of San Carlos, Talamban, Cebu City, 6000, Philippines.
Nanette R
NR
Lee
Division of Endocrine and Metabolism, Department of Internal Medicine, Chichung Veterans General Hospital, Taichung 40705, Taiwan.|School of Medicine, National Yang-Ming University, Taipei, Taiwan.
I-Te
IT
Lee
Department of Medical Research, Taichung Veterans General Hospital, Taichung 407, Taiwan.
Wen-Jane
WJ
Lee
National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.|Population Sciences Branch, National Heart Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Daniel
D
Levy
Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA.
Xiaohui
X
Li
Cardiovascular Center, Taichung Veterans General Hospital, Taichung, 40705, Taiwan.|Institute of Clinical Medicine, National Yang Ming University School of Medicine, Taipei 112, Taiwan.
Kae-Woei
KW
Liang
Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, 02446 MA, USA.|National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.
Honghuang
H
Lin
Cardiology, Department of Medicine, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland.
Li
L
Lin
National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Jaana
J
Lindström
European Genomic Institute for Diabetes (EGID), FR 3508 Lille, France.|Centre National de la Recherche Scientifique (CNRS) UMR 8199, Lille Pasteur Institute, 1 rue du Prof Calmette, 59019 Lille Cedex, France.|Lille 2 University, Lille, France.
Stéphane
S
Lobbens
National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Satu
S
Männistö
Center for Evidence-based Healthcare, University of Dresden, Medical Faculty Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany.
Gabriele
G
Müller
Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany.|Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians University, Munich, Germany.|Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, München 81377, Germany.
Martina
M
Müller-Nurasyid
Cardiology, Department of Medicine, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland.
François
F
Mach
Neurology Unit, University of Cambridge, R3, Box 83, Cambridge Biomedical Campus, Cambridge, Cb2 0QQ, UK.
Hugh S
HS
Markus
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.|Department of Dietetics-Nutrition, Harokopio University, 70 El. Venizelou Str, Athens, Greece.
Eirini
E
Marouli
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Mark I
MI
McCarthy
Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston 7, Jamaica.
Colin A
CA
McKenzie
INSERM U1142 LIMICS, UMR_S 1142 Sorbonne Universités, UPMC Université Paris 06, Université Paris 13, Paris, France.
Pierre
P
Meneton
Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Cristina
C
Menni
Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
Andres
A
Metspalu
Department of Life and Reproduction Sciences, University of Verona, Strada le Grazie 8, 37134 Verona, Italy.
Vladan
V
Mijatovic
Department of Medicine, Kuopio University Hospital, Kuopio, Finland.|Unit of General Practice, Oulu University Hospital, Oulu, Finland.
Leena
L
Moilanen
Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA.
May E
ME
Montasser
Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.
Andrew D
AD
Morris
Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, 1200 Pressler St., Suite 453E, Houston, TX 77030, USA.
Alanna C
AC
Morrison
Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monseratto, Monserrato, Cagliari 09042, Italy.
Antonella
A
Mulas
Laboratory of Genetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
Ramaiah
R
Nagaraja
Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Narisu
N
Narisu
Department of Cardiology, School of Medicine, University of Tampere, Tampere 33014, Finland.|School of Medicine, University of Tampere, Tampere 33014, Finland.
Kjell
K
Nikus
National Heart, Lung and Blood Institute, Division of Intramural Research, Bethesda, MD, USA.|National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.|Cardiology Division, Department of Medicine, Massachusetts General Hospital.
Christopher J
CJ
O'Donnell
Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK.
Paul F
PF
O'Reilly
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Ken K
KK
Ong
Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Route de la Corniche 10, 1010 Lausanne, Switzerland.
Fred
F
Paccaud
Divisions of Endocrinology, Children's Hospital Boston, Massachusetts 02115, USA.|Genetics and Program in Genomics, Children's Hospital Boston, Massachusetts 02115, USA.|Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA.
Cameron D
CD
Palmer
Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA.
Afshin
A
Parsa
Dept of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77 Stockholm, Sweden.
Nancy L
NL
Pedersen
Department of Psychiatry, EMGO Institute, Neuroscience Campus, VU University Medical Centre, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands.|Department of Psychiatry, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.|Department of Psychiatry, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The Netherlands.
Brenda W
BW
Penninx
National Institute for Health and Welfare, FI-00271 Helsinki, Finland.|Institute for Molecular Medicine Finland FIMM, University of Helsinki, 00290 Helsinki, Finland.|Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
Markus
M
Perola
Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg 85764, Germany.
Annette
A
Peters
International Centre for Circulatory Health, Imperial College London, W2 1PG, UK.
Neil
N
Poulter
Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, 39100, Italy - affiliated institute of the University of Lübeck, Germany.|Department of Neurology, General Central Hospital, Bolzano, 39100, Italy.|Department of Neurology, University of Lübeck, Lübeck, Germany.
Peter P
PP
Pramstaller
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.|Department of Epidemiology, University of Washington, Seattle, WA, USA.|Department of Health Services, University of Washington, Seattle, WA.|Group Health Research Institute, Group Health Cooperative, Seattle, WA.
Bruce M
BM
Psaty
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Thomas
T
Quertermous
Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO, 63110, USA.
Dabeeru C
DC
Rao
Center for Non-Communicable Diseases, Karachi, Pakistan.
Asif
A
Rasheed
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.|Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.|Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, UK.
N William N W R
NWNWR
Rayner
Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, SE-205 02 Malmö, Sweden.|Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.|Department of Public Health and Clinical Medicine, Umeå University, Sweden.
Frida
F
Renström
Institute of Physiology, University Medicine Greifswald, Greifswald, Germany.
Rainer
R
Rettig
Department of Biostatistics, University of Washington, Seattle, WA, USA.
Kenneth M
KM
Rice
University of Ottawa Heart Institute, Cardiovascular Research Methods Centre Ontario, Canada.|Ruddy Canadian Cardiovascular Genetics Centre, Ontario, Canada.
Robert
R
Roberts
Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave. East, Boston, MA 02215, USA.
Lynda M
LM
Rose
National Heart, Lung, and Blood Institute, 6701 Rockledge Ave., Bethesda, MD 20892, USA.
Jacques
J
Rossouw
Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.|Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester LE3 9QP, UK.
Nilesh J
NJ
Samani
Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monseratto, Monserrato, Cagliari 09042, Italy.
Serena
S
Sanna
South Karelia Central Hospital, Lappeenranta, Finland.
Jouko
J
Saramies
Deutsches Herzzentrum München, Germany.|Technische Universität München, Germany.|Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), München, Germany.|Munich Heart Alliance, Germany.
Heribert
H
Schunkert
Center For Life-course Health Research, P.O.Box 5000, FI-90014 University of Oulu, Finland.|Biocenter Oulu, P.O.Box 5000, Aapistie 5A, FI-90014 University of Oulu, Finland.|Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.
Sylvain
S
Sebert
Division of Endocrine and Metabolism, Department of Internal Medicine, Chichung Veterans General Hospital, Taichung 40705, Taiwan.|School of Medicine, National Yang-Ming University, Taipei, Taiwan.|College of Medicine, National Defense Medical Center, Taipei, Taiwan.
Wayne H-H
WH
Sheu
Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Young-Ah
YA
Shin
Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.|Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.|Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597.
Xueling
X
Sim
Department of Psychiatry, EMGO Institute, Neuroscience Campus, VU University Medical Centre, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands.
Johannes H
JH
Smit
Icelandic Heart Association, Kopavogur, Iceland.|Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Albert V
AV
Smith
Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Maria X
MX
Sosa
Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Tim D
TD
Spector
University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
Alena
A
Stančáková
Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland.
Alice
A
Stanton
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.|Department of Haematology, University of Cambridge, Cambridge, UK.
Kathleen E
KE
Stirrups
Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.|Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Heather M
HM
Stringham
Uppsala University, Department of Medical Sciences, SE-75185 Uppsala, Sweden.
Johan
J
Sundstrom
Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Amy J
AJ
Swift
Uppsala University, Department of Medical Sciences, SE-75185 Uppsala, Sweden.
Ann-Christine
AC
Syvänen
Department of Medicine, National University of Singapore and National University Health System, Singapore 119228, Singapore.|Duke-NUS Graduate Medical School Singapore, Singapore 169857, Singapore.|Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597.
E-Shyong
ES
Tai
Translational Gerontology Branch, National Institute on Aging, Baltimore MD, USA.
Toshiko
T
Tanaka
Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, 21224, USA.
Kirill V
KV
Tarasov
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Alexander
A
Teumer
deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.|Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Unnur
U
Thorsteinsdottir
Department of Health Sciences, University of Leicester, University Rd, Leicester LE1 7RH, UK.
Martin D
MD
Tobin
Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy.|Centro Cardiologico Monzino, IRCCS, Milan, Italy.
Elena
E
Tremoli
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA Rotterdam, The Netherlands.|Department of internal medicine, Erasmus MC, Rotterdam, 3000CA, The Netherlands.
Andre G
AG
Uitterlinden
Department of Public Health and Clinical Nutrition, University of Eastern Finland, Finland.|Research Unit, Kuopio University Hospital, Kuopio, Finland.
Matti
M
Uusitupa
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.|Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
Ahmad
A
Vaez
Johns Hopkins Medical Institutions, 1830 East Monument St., Baltimore, MD 21287, USA.
Dhananjay
D
Vaidya
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA Rotterdam, The Netherlands.|Centre of Medical Systems Biology (CMSB 1-2), NGI Erasmus Medical Center, Rotterdam, The Netherlands.
Cornelia M
CM
van Duijn
Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, The Netherlands.|Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands.
Erik P A
EPA
van Iperen
National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.|Section of Preventive medicine, Department of Medicine, Boston University School of Medicine, Boston, 02446 MA, USA.|Cardiology, Department of Medicine, Boston University School of Medicine, Boston, 02446 MA, USA.
Ramachandran S
RS
Vasan
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA Rotterdam, The Netherlands.
Germaine C
GC
Verwoert
National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Jarmo
J
Virtamo
Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU Scotland, UK.
Veronique
V
Vitart
Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA.|Department of Pharmacology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Benjamin F
BF
Voight
Department of Internal medicine, University Hospital Lausanne, Lausanne, Switzerland.
Peter
P
Vollenweider
Department of Epidemiology and Public Health, EA3430, University of Strasbourg, Strasbourg, France.
Aline
A
Wagner
Department of Health Sciences, University of Leicester, University Rd, Leicester LE1 7RH, UK.
Louise V
LV
Wain
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Nicholas J
NJ
Wareham
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.|Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Hugh
H
Watkins
Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Alan B
AB
Weder
University Medical Center Groningen, University of Groningen, Groningen, 9700RB, The Netherlands.
Harm-Jan
HJ
Westra
Epidemiology Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston 7, Jamaica.
Rainford
R
Wilks
Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.|Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.
Tom
T
Wilsgaard
Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.|Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU Scotland, UK.
James F
JF
Wilson
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore.|Duke-NUS Graduate Medical School Singapore, Singapore 169857, Singapore.|Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228.
Tien Y
TY
Wong
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.|MRC Cancer Unit, University of Cambridge, Cambridge, UK.
Tsun-Po
TP
Yang
Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA.
Jie
J
Yao
European Genomic Institute for Diabetes (EGID), FR 3508 Lille, France.|Centre National de la Recherche Scientifique (CNRS) UMR 8199, Lille Pasteur Institute, 1 rue du Prof Calmette, 59019 Lille Cedex, France.|Lille 2 University, Lille, France.
Loic
L
Yengo
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.|Department of Cardiology, Ealing Hospital NHS Trust, Uxbridge Road, Southall, Middlesex UB1 3EU, UK.
Weihua
W
Zhang
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Jing Hua
JH
Zhao
Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
Xiaofeng
X
Zhu
Ministry of Health, Victoria, Republic of Seychelles.|Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Route de la Corniche 10, 1010 Lausanne, Switzerland.
Pascal
P
Bovet
Department of Preventive Medicine and Epidemiology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 60153, USA.
Richard S
RS
Cooper
Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Karen L
KL
Mohlke
Department of Biostatistics and Epidemiology, University of Pennsylvania, USA.|Center for Non-Communicable Diseases, Karachi, Pakistan.
Danish
D
Saleheen
Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Jong-Young
JY
Lee
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.|MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.
Paul
P
Elliott
Dept. Dev. Bio. And Genetics, Stanford University Medical Center, Stanford, CA 94305, USA.|Enterprise Informatics, Illumina Inc., Santa Clara CA, 95050, USA.
Hinco J
HJ
Gierman
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.|Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.|Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Cristen J
CJ
Willer
Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, 9711, The Netherlands.
Lude
L
Franke
Dept Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.
G Kees
GK
Hovingh
Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA.
Kent D
KD
Taylor
Department of Dietetics-Nutrition, Harokopio University, 70 El. Venizelou Str, Athens, Greece.
George
G
Dedoussis
International Centre for Circulatory Health, Imperial College London, W2 1PG, UK.
Peter
P
Sever
MRC Unit for Lifelong Health and Ageing at UCL, London, WC1B 5JU, UK.
Andrew
A
Wong
Uppsala University, Department of Medical Sciences, SE-75185 Uppsala, Sweden.
Lars
L
Lind
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Themistocles L
TL
Assimes
Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.|Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.
Inger
I
Njølstad
Dept of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany.
Peter Eh
PE
Schwarz
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Claudia
C
Langenberg
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
Harold
H
Snieder
Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.|NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, EC1M 6BQ, UK.
Mark J
MJ
Caulfield
University of Lund, Dept Internal Medicine, Malmo, SE 20502, Sweden.
Olle
O
Melander
Department of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
Markku
M
Laakso
Department of Medicine, Central Finland Health Care District, Jyväskylä, Finland.
Juha
J
Saltevo
Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.|Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.
Rainer
R
Rauramaa
National Institute for Health and Welfare, FI-00271 Helsinki, Finland.|Dasman Diabetes Institute, Dasman, 15462 Kuwait.|Saudi Diabetes Research Group, King Abdulaziz University, 21589 Jeddah, Saudi Arabia.|Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria.
Jaakko
J
Tuomilehto
Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.|Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
Erik
E
Ingelsson
Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.|Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33014, Finland.
Terho
T
Lehtimäki
HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, Norway.
Kristian
K
Hveem
Department of Medicine, Columbia University, 622 West 168th St., New York, NY 10032, USA.
Walter
W
Palmas
Synlab Academy, Synlab Services GmbH, P5, 7, 68161 Mannheim, Germany.|Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036 Graz, Austria.
Winfried
W
März
Genetic Epidemiology Group, Dept. Epidemiology and Public Health, UCL, London, WC1E 6BT, UK.
Meena
M
Kumari
National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Veikko
V
Salomaa
Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA.
Yii-Der I
YI
Chen
Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA.
Jerome I
JI
Rotter
European Genomic Institute for Diabetes (EGID), FR 3508 Lille, France.|Centre National de la Recherche Scientifique (CNRS) UMR 8199, Lille Pasteur Institute, 1 rue du Prof Calmette, 59019 Lille Cedex, France.|Lille 2 University, Lille, France.|Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK.
Philippe
P
Froguel
Center For Life-course Health Research, P.O.Box 5000, FI-90014 University of Oulu, Finland.|Biocenter Oulu, P.O.Box 5000, Aapistie 5A, FI-90014 University of Oulu, Finland.|Unit of Primary Care, Oulu University Hospital, Kajaanintie 50, P.O.Box 20, FI-90220 Oulu, 90029 OYS, Finland.|MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.
Marjo-Riitta
MR
Jarvelin
Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, 21224, USA.
Edward G
EG
Lakatta
National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Kari
K
Kuulasmaa
Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, SE-205 02 Malmö, Sweden.|Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.|Department of Public Health and Clinical Medicine, Umeå University, Sweden.
Paul W
PW
Franks
Cardiovascular Research Unit, Center for Molecular Medicine L8:03, Department of Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden.|Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.
Anders
A
Hamsten
Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg 85764, Germany.|Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, München 81377, Germany.|Grosshadern, Klinikum, München 81377, Germany.
H-Erich
HE
Wichmann
Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.
Colin N A
CNA
Palmer
deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.|Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Kari
K
Stefansson
Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave. East, Boston, MA 02215, USA.|Harvard Medical School, Boston, MA 02115, USA.
Paul M
PM
Ridker
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.|The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.|Mindich Child health Development Institute, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Ruth J F
RJF
Loos
Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Aravinda
A
Chakravarti
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.|Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Panos
P
Deloukas
Department of Biostatistics, University of Liverpool, Liverpool L69 3GA, UK.|Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
Andrew P
AP
Morris
Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA.|Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.|Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA.|Broad Institute of Harvard and MIT, Cambridge, MA 02139 USA.
Christopher
C
Newton-Cheh
Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.|NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, EC1M 6BQ, UK.
Patricia B
PB
Munroe
D044466:Asian People / Q000235:genetics; D044383:Black People / Q000235:genetics; D001794:Blood Pressure / Q000235:genetics*; D002478:Cells, Cultured; D055106:Genome-Wide Association Study; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000473:pathology; D046228:Microarray Analysis; D020641:Polymorphism, Single Nucleotide