Photo-induced graft-versus-host disease.
Overlap chronic graft-versus-host disease (GVHD) associates both features of acute and chronic GVHD. Trigger factors for chronic GVHD are unclear. We describe two patients who received allogenic haematopoietic stem-cell transplantation, and who later developed overlap chronic GVHD after sun exposure. Available data from in vivo investigations suggest ultraviolet B radiation (UVB) has a beneficial effect on acute and chronic GVHD. The role of sun irradiation as a trigger for isomorphic cutaneous GVHD has been rarely reported in the literature. Herein, we demonstrate for the first time, using repetitive broadband phototesting, that UVB triggers chronic GVHD.
Department of Dermatology, Toulouse University Hospital, Paul Sabatier University, Toulouse, France.
Juliette M
JM
Hardy
Department of Dermatology, Toulouse University Hospital, Paul Sabatier University, Toulouse, France.
Marie-Claude
MC
Marguery
Department of Hematology, IUCT-O, Toulouse University Hospital, Toulouse, France.
Anne
A
Huynh
Department of Hematology, IUCT-O, Toulouse University Hospital, Toulouse, France.
Cécile
C
Borel
Laboratory of Immunology, Toulouse University Hospital, Toulouse, France.
Pol André
PA
Apoil
Pathology Laboratory, Oncopôle-IUC, Toulouse, France.
Laurence
L
Lamant
Pathology Laboratory, Oncopôle-IUC, Toulouse, France.
Emilie
E
Tournier
Department of Dermatology, Toulouse University Hospital, Paul Sabatier University, Toulouse, France.
Chloé
C
Alberto
Department of Dermatology, Toulouse University Hospital, Paul Sabatier University, Toulouse, France.
Céline
C
Pauwels
Department of Dermatology, Toulouse University Hospital, Paul Sabatier University, Toulouse, France.
Marianne
M
Thomas
Department of Dermatology, Toulouse University Hospital, Paul Sabatier University, Toulouse, France.
Juliette
J
Mazereeuw Hautier
Department of Dermatology, Toulouse University Hospital, Paul Sabatier University, Toulouse, France.
Carle
C
Paul
Department of Dermatology, Toulouse University Hospital, Paul Sabatier University, Toulouse, France.
Cristina
C
Bulai Livideanu
D000328:Adult; D064591:Allografts; D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000209:etiology / Q000473:pathology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D012871:Skin Diseases / Q000209:etiology / Q000473:pathology; D014466:Ultraviolet Rays / Q000009:adverse effects*
overlap chronic GVH disease; photodermatosis; ultraviolet B; ultraviolet radiation