[Epidemiology of multi-drug resistant gramnegative bacilli].
Current antimicrobial resistance in Gram negative bacilli is particularly worrisome due to development of resistance to all available antimicrobial agents. This situation dramatically limits therapeutic options. The microorganisms acquire a multiresistance phenotype as a consequence of different complex processes in which the antimicrobials acts as selective driver of resistance. Dissemination of multiresistant bacteria is driven by the expansion of the high-risk clones. These clones can be selected in the presence of antimicrobials allowing their persistence over time.
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Rafael Cantón, Servicio de Microbiología. Hospital Universitario Ramón y Cajal. 28034-Madrid. Spain. rafael.canton@salud.madrid.org.
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D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D016905:Gram-Negative Bacterial Infections / Q000453:epidemiology* / Q000235:genetics / Q000382:microbiology*; D006801:Humans
D000900:Anti-Bacterial Agents