Nano-structures mediated co-delivery of therapeutic agents for glioblastoma treatment: A review.
Glioblastoma is a malignant brain tumor and leads to death in most patients. Chemotherapy is a common method for brain cancer in clinics. However, the recent advancements in the chemotherapy of brain tumors have not been efficient enough. With the advancement of nanotechnology, the used drugs can enhance chemotherapy efficiency and increase the access to brain cancers. Combination of therapeutic agents has been recently attracted great attention for glioblastoma chemotherapy. One of the early benefits of combination therapies is the high potential to provide synergistic effects and decrease adverse side effects associated with high doses of single anticancer drugs. Therefore, brain tumor treatments with combination drugs can be considered as a crucial approach for avoiding tumor growth. This review investigates current progress in nano-mediated co-delivery of therapeutic agents with focus on glioblastoma chemotherapy prognosis.
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, International Campus, Tehran University of Medical Sciences, Tehran, Iran.
Basil
B
Mujokoro
Young Researchers and Elite Club, Roudehen Branch, Islamic Azad University, Roudehen, Iran.
Mohsen
M
Adabi
Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Esmaeil
E
Sadroddiny
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: madabi@tums.ac.ir.
Mahdi
M
Adabi
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: drkhosravani@tums.ac.ir.
Masood
M
Khosravani
D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000633:toxicity; D017209:Apoptosis / Q000187:drug effects; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004337:Drug Carriers / Q000737:chemistry*; D018014:Gene Transfer Techniques; D005909:Glioblastoma / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D034741:RNA, Small Interfering / Q000737:chemistry / Q000378:metabolism
D000970:Antineoplastic Agents; D004337:Drug Carriers; D034741:RNA, Small Interfering
Chemosensitizer; Chemotherapy; Co-delivery; Drug delivery; Gene therapy; Glioblastoma; Nanoparticle