Construction of Pyrrolo[1,2-a]indoles via Cobalt(III)-Catalyzed Enaminylation of 1-(Pyrimidin-2-yl)-1H-indoles with Ketenimines and Subsequent Base-Promoted Cyclization.
A cobalt(III)-catalyzed cross-coupling reaction of 1-(pyrimidin-2-yl)-1H-indoles with ketenimines is reported. The reaction provided 2-enaminylated indole derivatives in moderate to excellent yields with a broad substrate scope. The prepared 2-enaminylated indoles could be conveniently converted into pyrrolo[1,2-a]indoles, which are an important class of compounds in medicinal chemistry.
Department of Chemistry, Zhejiang University , Hangzhou 310027, P. R. China.
Xiaorong
X
Zhou
Department of Chemistry, Zhejiang University , Hangzhou 310027, P. R. China.
Zili
Z
Fan
Department of Chemistry, Zhejiang University , Hangzhou 310027, P. R. China.
Zhiyin
Z
Zhang
Department of Chemistry, Zhejiang University , Hangzhou 310027, P. R. China.
Ping
P
Lu
Department of Chemistry, Zhejiang University , Hangzhou 310027, P. R. China.
Yanguang
Y
Wang