Intercellular Networks Underlying Developmental Decisions.
In this issue of Neuron, Yuzwa et al. (2016) identify secreted factors that influence the cell fates of embryonic neural progenitor cells. Surprisingly, the major contributors are trophic factors from the GDNF family and a cytokine, interferon-γ. Advanced analysis of proteomic and transcriptome data discovered ligand receptors that influence cell-cell communication.
Departments of Cell Biology, Physiology & Neuroscience, and Psychiatry, Skirball Institute of Biomolecular Medicine, New York University Langone Medical School, New York, NY 10016, USA. Electronic address: moses.chao@med.nyu.edu.
Moses V
MV
Chao
D051100:Glial Cell Line-Derived Neurotrophic Factor; D051097:Glial Cell Line-Derived Neurotrophic Factor Receptors; D009414:Nerve Growth Factors; D058953:Neural Stem Cells; D009474:Neurons; D040901:Proteomics
D051100:Glial Cell Line-Derived Neurotrophic Factor; D051097:Glial Cell Line-Derived Neurotrophic Factor Receptors; D009414:Nerve Growth Factors