Revisiting the role of environmental and climate factors on the epidemiology of Kawasaki disease.
Can environmental factors, such as air-transported preformed toxins, be of key relevance to the health outcomes of poorly understood human ailments (e.g., rheumatic diseases such as vasculitides, some inflammatory diseases, or even severe childhood acquired heart diseases)? Can the physical, chemical, or biological features of air masses be linked to the emergence of diseases such as Kawasaki disease (KD), Henoch-Schönlein purpura, Takayasu's aortitis, and ANCA-associated vasculitis? These diseases surprisingly share some common epidemiological features. For example, they tend to appear as clusters of cases grouped geographically and temporarily progress in nonrandom sequences that repeat every year in a similar way. They also show concurrent trend changes within regions in countries and among different world regions. In this paper, we revisit transdisciplinary research on the role of environmental and climate factors in the epidemiology of KD as a paradigmatic example of this group of diseases. Early-warning systems based on environmental alerts, if successful, could be implemented as a way to better inform patients who are predisposed to, or at risk for, developing KD. Further research on the etiology of KD could facilitate the development of vaccines and specific medical therapies.
Institut Català de Ciències del Clima (IC3).|Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
Xavier
X
Rodó
Institut Català de Ciències del Clima (IC3).
Joan
J
Ballester
Institut Català de Ciències del Clima (IC3).
Roger
R
Curcoll
Institut Català de Ciències del Clima (IC3).
Joseph
J
Boyard-Micheau
Institut Català de Ciències del Clima (IC3).
Sílvia
S
Borràs
Institut Català de Ciències del Clima (IC3).
Josep-Anton
JA
Morguí
D002980:Climate; D004781:Environmental Exposure / Q000009:adverse effects*; D006801:Humans; D009080:Mucocutaneous Lymph Node Syndrome / Q000175:diagnosis / Q000453:epidemiology*; D012621:Seasons; D014919:Wind
Kawasaki disease; environmental toxins; epidemiology; vasculitides; wind