Diet-Intestinal Microbiota Axis in Osteoarthritis: A Possible Role.
Intestinal microbiota is highly involved in host physiology and pathology through activity of the microbiome and its metabolic products. Osteoarthritis (OA) is a common form of arthritis characterized by articular cartilage destruction and osteophyte formation. Although various person-level risk factors, such as age, sex, and obesity, have been proposed for the pathogenesis of OA, the underlying links between these person-level factors and OA are still enigmatic. Based on the current understanding in the crosstalk between intestinal microbiota and these risk factors, intestinal microbiota could be considered as a major hidden risk factor that provides a unifying mechanism to explain the involvement of these person-level risk factors in OA.
Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China.
Yusheng
Y
Li
Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China.
Wei
W
Luo
Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China.
Zhenhan
Z
Deng
Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China.
Guanghua
0000-0001-9230-9053
G
Lei
D000818:Animals; D002358:Cartilage, Articular / Q000382:microbiology*; D004032:Diet; D005260:Female; D000069196:Gastrointestinal Microbiome; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000150:complications; D010003:Osteoarthritis / Q000150:complications / Q000382:microbiology / Q000503:physiopathology*; D012307:Risk Factors; D012737:Sex Factors