The Ultimaster Biodegradable-Polymer Sirolimus-Eluting Stent: An Updated Review of Clinical Evidence.
The Ultimaster coronary stent system (Terumo Corporation, Tokyo, Japan) represents a new iteration in drug-eluting stent (DES) technology that has recently received the Conformité Européenne (CE) mark approval for clinical use. The Ultimaster is a thin-strut, cobalt chromium, biodegradable-polymer, sirolimus-eluting coronary stent. The high elasticity of the biodegradable-polymer (PDLLA-PCL) and the abluminal gradient coating technology are additional novel features of this coronary device. The Ultimaster DES has undergone extensive clinical evaluation in two studies: The CENTURY I and II trials. Results from these two landmark studies suggested an excellent efficacy and safety profile of the Ultimaster DES across several lesion and patient subsets, with similar clinical outcomes to contemporary, new-generation DES. The aim of this review is to summarize the rationale behind this novel DES technology and to provide an update of available evidence about the clinical performance of the Ultimaster DES.
Division of Cardiology, Santa Corona Hospital, Via XXV Aprile, 38, Pietra Ligure 17027, Italy. albertochisari@yahoo.it.
Alberto
A
Chisari
Division of Cardiology, San Paolo Hospital, Savona 17100, Italy. annamariapistritto@hotmail.it.
Anna Maria
AM
Pistritto
Department of Cardiology, Bern University Hospital, University of Bern, Bern 3010, Switzerland. Raffaele.Piccolo@insel.ch.
Raffaele
R
Piccolo
Cardiovascular Department, Ferrarotto Hospital, University of Catania, Catania 95124, Italy. lamanna.cardio@gmail.com.
Alessio
A
La Manna
Division of Cardiology, Santa Corona Hospital, Via XXV Aprile, 38, Pietra Ligure 17027, Italy. gbdanzi@tin.it.
Gian Battista
GB
Danzi
D000800:Angioplasty, Balloon / Q000009:adverse effects / Q000379:methods*; D063566:Biodegradable Plastics / Q000009:adverse effects / Q000737:chemistry; D017321:Clinical Trials, Phase I as Topic; D017322:Clinical Trials, Phase II as Topic; D054855:Drug-Eluting Stents / Q000009:adverse effects*; D006801:Humans; D020123:Sirolimus / Q000008:administration & dosage*
D063566:Biodegradable Plastics; D020123:Sirolimus
Ultimaster stent; biodegradable polymer drug eluting stent; coronary stent; new-generation DES; sirolimus-eluting stent