Skin disease and thyroid autoimmunity in atopic South Italian children.
OBJECTIVE
To verify the prevalence of thyroid autoimmunity (TA) and the possible association between atopy and TA in children affected by skin disease.


METHODS
Three hundred and twenty-four children consecutively referred due to skin disease symptoms to our Pediatric Department were enrolled. One hundred and eighty-seven were diagnosed with atopic dermatitis (AD), 95 with acute urticaria, 40 with chronic urticaria (CU), and 2 with alopecia areata (AA). According to the work-up for atopy, the children were divided into two groups: Atopics and non-atopics. TA was diagnosed by serum thyroid peroxidase autoantibodies and/or thyroglobulin autoantibodies levels more than twice normal values over a period of two months by immunoassay.


RESULTS
In all children with skin disease, a significant prevalence of TA in atopics compared with non-atopics (13.67% vs 2.67%, P = 0.0016) and a significant association between TA and atopy (OR = 5.76, 95%CI: 1.71-19.35) were observed. These findings were confirmed as significant in children with AD: TA in atopics was 11.5%, while TA in non-atopics was 2.7% (P = 0.03, OR = 4.68, 95%CI: 1.02-21.38). In addition, atopics with CU showed a significantly higher prevalence of TA (26.9%), but none of the non-atopics showed CU (P = 0.0326). On the other hand, atopics with AA showed a 100% (2 out of 2) prevalence of TA, compared with none of the non-atopics.


CONCLUSIONS
In children with skin disease, atopy seems to be associated with an increased risk of TA.
Marcella Pedullà, Vincenzo Fierro, Pierluigi Marzuillo, Francesco Capuano, Emanuele Miraglia del Giudice, Department of Woman, Child and General and Specialized Surgery, Seconda Università degli Studi di Napoli, 80138 Napoli, Italy.
Marcella
M
Pedullà
Marcella Pedullà, Vincenzo Fierro, Pierluigi Marzuillo, Francesco Capuano, Emanuele Miraglia del Giudice, Department of Woman, Child and General and Specialized Surgery, Seconda Università degli Studi di Napoli, 80138 Napoli, Italy.
Vincenzo
V
Fierro
Marcella Pedullà, Vincenzo Fierro, Pierluigi Marzuillo, Francesco Capuano, Emanuele Miraglia del Giudice, Department of Woman, Child and General and Specialized Surgery, Seconda Università degli Studi di Napoli, 80138 Napoli, Italy.
Pierluigi
P
Marzuillo
Marcella Pedullà, Vincenzo Fierro, Pierluigi Marzuillo, Francesco Capuano, Emanuele Miraglia del Giudice, Department of Woman, Child and General and Specialized Surgery, Seconda Università degli Studi di Napoli, 80138 Napoli, Italy.
Francesco
F
Capuano
Marcella Pedullà, Vincenzo Fierro, Pierluigi Marzuillo, Francesco Capuano, Emanuele Miraglia del Giudice, Department of Woman, Child and General and Specialized Surgery, Seconda Università degli Studi di Napoli, 80138 Napoli, Italy.
Emanuele
E
Miraglia Del Giudice
Marcella Pedullà, Vincenzo Fierro, Pierluigi Marzuillo, Francesco Capuano, Emanuele Miraglia del Giudice, Department of Woman, Child and General and Specialized Surgery, Seconda Università degli Studi di Napoli, 80138 Napoli, Italy.
Eleonora
E
Ruocco
Atopic dermatitis; Children; Skin disease; Thyroid autoimmunity