Apoptosis in Porcine Pluripotent Cells: From ICM to iPSCs.
Pigs have great potential to provide preclinical models for human disease in translational research because of their similarities with humans. In this regard, porcine pluripotent cells, which are able to differentiate into cells of all three primary germ layers, might be a suitable animal model for further development of regenerative medicine. Here, we describe the current state of knowledge on apoptosis in pluripotent cells including inner cell mass (ICM), epiblast, embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs). Information is focused on the apoptotic phenomenon in pluripotency, maintenance, and differentiation of pluripotent stem cells and reprogramming of somatic cells in pigs. Additionally, this review examines the multiple roles of apoptosis and summarizes recent progress in porcine pluripotent cells.
Institute for Stem Cell & Regenerative Medicine (ISCRM), Chungbuk National University, Cheongju 28644, Chungbuk, Korea. iwsleh@nate.com.|Laboratory of Veterinary Embryology and Biotechnology(VETEMBIO), Veterinary Medical Center and Collage of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Chungbuk, Korea. iwsleh@nate.com.
Eunhye
E
Kim
Institute for Stem Cell & Regenerative Medicine (ISCRM), Chungbuk National University, Cheongju 28644, Chungbuk, Korea. shhyun@cbu.ac.kr.|Laboratory of Veterinary Embryology and Biotechnology(VETEMBIO), Veterinary Medical Center and Collage of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Chungbuk, Korea. shhyun@cbu.ac.kr.
Sang-Hwan
SH
Hyun
D000818:Animals; D017209:Apoptosis; D053624:Blastocyst Inner Cell Mass / Q000166:cytology*; D002454:Cell Differentiation; D065150:Cellular Reprogramming; D053595:Embryonic Stem Cells / Q000166:cytology; D005855:Germ Layers / Q000166:cytology*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology*; D039904:Pluripotent Stem Cells / Q000166:cytology*; D044968:Regenerative Medicine; D013552:Swine
apoptosis; embryo; embryonic stem cells; induced pluripotent stem cells; pigs