Modern management of phagocyte defects.
Phagocytic neutrophil granulocytes are among the first immune cells active at sites of infection, forming an important first-line defense against invading microorganisms. Congenital immune defects concerning these phagocytes may be due to reduced neutrophil numbers or function. Management of affected patients depends on the type and severity of disease. Here, we provide an overview of causes and treatment of diseases associated with congenital neutropenia, as well as defects of the phagocytic respiratory burst.
Division of Immunology, University Children's Hospital Zurich and Children's Research Centre, University Zurich, Switzerland.
Lorenza Lisa Serena
LL
Lanini
Division of Immunology, University Children's Hospital Zurich and Children's Research Centre, University Zurich, Switzerland.
Seraina
S
Prader
Division of Immunology, University Children's Hospital Zurich and Children's Research Centre, University Zurich, Switzerland.
Ulrich
U
Siler
Division of Immunology, University Children's Hospital Zurich and Children's Research Centre, University Zurich, Switzerland.
Janine
J
Reichenbach
D000818:Animals; D019072:Antibiotic Prophylaxis; D002454:Cell Differentiation; D000080984:Congenital Bone Marrow Failure Syndromes; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006105:Granulomatous Disease, Chronic / Q000276:immunology* / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D007113:Immunity, Innate; D007153:Immunologic Deficiency Syndromes / Q000235:genetics / Q000276:immunology* / Q000628:therapy; D038042:Myelopoiesis / Q000235:genetics; D009503:Neutropenia / Q000151:congenital* / Q000235:genetics / Q000276:immunology / Q000628:therapy; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis / Q000235:genetics; D000081207:Primary Immunodeficiency Diseases; D016897:Respiratory Burst / Q000235:genetics; D014860:Warts / Q000235:genetics / Q000276:immunology* / Q000628:therapy
D016179:Granulocyte Colony-Stimulating Factor
CGD; G-CSF; HSCT; Phagocyte defects; chronic granulomatous disease; congenital neutropenia; gene therapy