Development of Novel Immunotherapies for Multiple Myeloma.
Multiple myeloma (MM) is a disorder of terminally differentiated plasma cells characterized by clonal expansion in the bone marrow (BM). It is the second-most common hematologic malignancy. Despite significant advances in therapeutic strategies, MM remains a predominantly incurable disease emphasizing the need for the development of new treatment regimens. Immunotherapy is a promising treatment modality to circumvent challenges in the management of MM. Many novel immunotherapy strategies, such as adoptive cell therapy and monoclonal antibodies, are currently under investigation in clinical trials, with some already demonstrating a positive impact on patient survival. In this review, we will summarize the current standards of care and discuss major new approaches in immunotherapy for MM.
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA. ealhejaily@gmail.com.
Ensaf M
EM
Al-Hujaily
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA. robyn.oldham@mail.utoronto.ca.|Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada. robyn.oldham@mail.utoronto.ca.
Robyn A A
RA
Oldham
Department of Medicine, Division of Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, USA. phari@mcw.edu.
Parameswaran
P
Hari
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA. jmedin@mcw.edu.|Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada. jmedin@mcw.edu.|The Institute of Medical Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada. jmedin@mcw.edu.|Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA. jmedin@mcw.edu.|Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA. jmedin@mcw.edu.
Jeffrey A
JA
Medin
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D009101:Multiple Myeloma / Q000276:immunology / Q000628:therapy*
D000911:Antibodies, Monoclonal
CAR-T cell therapy; monoclonal antibodies; multiple myeloma; stem cell transplantation