SNP rs1805874 of the Calbindin1 Gene Is Associated with Parkinson's Disease in Han Chinese.
OBJECTIVE
The single-nucleotide polymorphism, rs1805874, in the Calbindin1 gene has been associated with Parkinson's disease among the Japanese people, but not among Europeans or Americans. To help clarify these contrasting results, we conducted a case-control study to explore whether such an association exists among the Han Chinese.


METHODS
We used the ligase detection reaction to genotype the rs1805874 SNP in 514 Han Chinese with Parkinson's disease as well as in 475 healthy Han Chinese controls.


RESULTS
We identified a significant association between the A allele of rs1805874 and the risk of Parkinson's disease (OR 1.257, 95% CI 1.036-1.524, p = 0.020). Subgroup analysis revealed a significant association of the A allele with male gender (OR 1.306, 95% CI 1.009-1.691, p = 0.042) and late onset of disease (OR 1.247, 95% CI 1.010-1.540, p = 0.040).


CONCLUSIONS
Our findings suggest that the A allele of rs1805874 is associated with risk of Parkinson's disease among the Han Chinese. Our results, combined with previous studies, suggest that rs1805874 is associated with Parkinson's disease in East Asians, but not Caucasians.
Department of Neurology, West China Hospital, Sichuan University , Chengdu, People's Republic of China .
Xinglong
X
Yang
Department of Neurology, West China Hospital, Sichuan University , Chengdu, People's Republic of China .
Quanzhen
Q
Zhao
Department of Neurology, West China Hospital, Sichuan University , Chengdu, People's Republic of China .
Ran
R
An
Department of Neurology, West China Hospital, Sichuan University , Chengdu, People's Republic of China .
Huayong
H
Zhou
Department of Neurology, West China Hospital, Sichuan University , Chengdu, People's Republic of China .
Zhenfang
Z
Lin
Department of Neurology, West China Hospital, Sichuan University , Chengdu, People's Republic of China .
Yanming
Y
Xu
D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D064092:Calbindin 1 / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D002681:China; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D044465:White People / Q000235:genetics
C576498:CALB1 protein, human; D064092:Calbindin 1
Calbindin1; Parkinson's disease; genetic polyporphism; rs1805874