The Diverse Family of Arp2/3 Complexes.
The Arp2/3 complex has so far been considered to be a single seven-subunit protein complex required for actin nucleation and actin filament polymerization in diverse critical cellular functions including phagocytosis, vesicular trafficking and lamellipodia extension. The Arp2/3 complex is also exploited by bacterial pathogens and viruses during cellular infectious processes. Recent studies suggest that some subunits of the complex are dispensable in specific cellular contexts, pointing to the existence of alternative 'hybrid Arp2/3 complexes' containing other components such as vinculin or α-actinin, as well as different isoforms or phosphorylation variants of canonical Arp2/3 subunits. Therefore, this diversity should be now considered when assigning specific Arp2/3 assemblies to different actin-dependent cellular processes.
Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris F-75015, France; INSERM, U604, Paris F-75015, France; INRA, USC2020, Paris F-75015, France. Electronic address: javier.pizarro-cerda@pasteur.fr.
Javier
J
Pizarro-Cerdá
The Weizmann Institute of Science, Department of Molecular Cell Biology, Rehovot 761001, Israel; Department of Chemistry, University of Oxford, Physical and Theoretical Chemistry Laboratory, Oxford OX1 3QZ, UK.
Dror Shlomo
DS
Chorev
The Weizmann Institute of Science, Department of Molecular Cell Biology, Rehovot 761001, Israel.
Benjamin
B
Geiger
Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris F-75015, France; INSERM, U604, Paris F-75015, France; INRA, USC2020, Paris F-75015, France. Electronic address: pascale.cossart@pasteur.fr.
Pascale
P
Cossart
D051376:Actin-Related Protein 2-3 Complex / Q000378:metabolism*; D000818:Animals; D006801:Humans; D008954:Models, Biological; D005810:Multigene Family
D051376:Actin-Related Protein 2-3 Complex
Arp2/3; Listeria monocytogenes; actin polymerization; focal adhesions; vaccinia virus