Therapeutic drug monitoring of antiretroviral drugs in HIV-infected patients.
Therapeutic drug monitoring (TDM) may be beneficial when applied to antiretroviral (ARV). Even though TDM can be a valuable strategy in HIV management, its role remains controversial. Areas covered: This review provides a comprehensive update on important issues relating to TDM of ARV drugs in HIV-infected patients. Articles from PubMed with keywords relevant to each topic section were reviewed. Search strategies limited to articles published in English. Expert commentary: There is evidence supporting the use of TDM in HIV treatment. However, some limitations need to be considered. The evidence supporting the use of routine TDM for all patients is limited, as it is not clear that this strategy offers any advantages over TDM for selected indications. Selected groups of patients including patients with physiological changes, patients with drug-drug interactions or toxicity, and the elderly could potentially benefit from TDM, as optimized dosing is challenging in these populations.
a Department of Pharmaceutical Care, Faculty of Pharmacy , Chiang Mai University , Chiang Mai , Thailand.
Baralee
B
Punyawudho
a Department of Pharmaceutical Care, Faculty of Pharmacy , Chiang Mai University , Chiang Mai , Thailand.
Noppaket
N
Singkham
b HIV-NAT , Thai Red Cross AIDS Research Centre , Bangkok , Thailand.
Narukjaporn
N
Thammajaruk
b HIV-NAT , Thai Red Cross AIDS Research Centre , Bangkok , Thailand.
Theera
T
Dalodom
b HIV-NAT , Thai Red Cross AIDS Research Centre , Bangkok , Thailand.|c The Kirby Institute, University of New South Wales , Sydney , Australia.|d Department of Global Health, Academic Medical Center , University of Amsterdam, Amsterdam Institute for Global Health and Development , Amsterdam , The Netherlands.
Stephen J
SJ
Kerr
e Radbound University Medical Center , Nijmegen , The Netherlands.
David M
DM
Burger
b HIV-NAT , Thai Red Cross AIDS Research Centre , Bangkok , Thailand.|f Faculty of Medicine , Chulalongkorn University , Bangkok , Thailand.
Kiat
K
Ruxrungtham
D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000097:blood / Q000145:classification / Q000627:therapeutic use*; D016903:Drug Monitoring / Q000379:methods*; D024882:Drug Resistance, Viral; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy*; D015497:HIV-1 / Q000187:drug effects; D006801:Humans
D019380:Anti-HIV Agents
HIV; Therapeutic drug monitoring; antiretroviral drugs