Synthesis and antiproliferative activity of new tonantzitlolone-derived diterpene derivatives.
The synthesis of the diterpene (+)-tonantzitlolone A and a series of derivatives is reported. The study includes the determination of their antiproliferative activities against selected cancer cell lines.
Institut für Organische Chemie and Biomolekulares Wirkstoffzentrum (BMWZ), Leibniz Universität Hannover, Schneiderberg 1b, 30167 Hannover, Germany. andreas.kirschning@oci.uni-hannover.de.
Torsten
T
Busch
Gerald
G
Dräger
Eike
E
Kunst
Hannah
H
Benson
Florenz
F
Sasse
Karsten
K
Siems
Andreas
A
Kirschning
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000970:Antineoplastic Agents; D004224:Diterpenes; D047028:Macrocyclic Compounds; C510266:tonantzitlolone