Mutation in the Drosophila insulin-like receptor substrate, chico, affects the neuroendocrine stress-reaction development.
It is shown for the first time that the insulin receptor substrate gene chico controls the functioning of the systems of metabolism of dopamine and juvenile hormone in Drosophila melanogaster females under normal conditions and in thermal stress.
Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, pr. Akademika Lavrent'eva 10, Novosibirsk, 630090, Russia. nataly@bionet.nsc.ru.
E K
EK
Karpova
Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, pr. Akademika Lavrent'eva 10, Novosibirsk, 630090, Russia.
I Yu
IY
Rauschenbach
Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, pr. Akademika Lavrent'eva 10, Novosibirsk, 630090, Russia.
E V
EV
Burdina
Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, pr. Akademika Lavrent'eva 10, Novosibirsk, 630090, Russia.
N E
NE
Gruntenko
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D030801:Animals, Genetically Modified; D004298:Dopamine / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism*; D005260:Female; D018882:Heat Stress Disorders / Q000235:genetics* / Q000378:metabolism*; D055504:Insulin Receptor Substrate Proteins / Q000235:genetics* / Q000378:metabolism*; D007605:Juvenile Hormones / Q000378:metabolism; D009154:Mutation; D013312:Stress, Physiological / Q000235:genetics / Q000502:physiology; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D029721:Drosophila Proteins; D055504:Insulin Receptor Substrate Proteins; D007605:Juvenile Hormones; C120233:chico protein, Drosophila; D014446:Tyrosine 3-Monooxygenase; D000469:Alkaline Phosphatase; D004298:Dopamine