Anemia and markers of erythropoiesis in pediatric kidney transplant recipients compared to children with chronic renal failure.
PTA and anemia of CKD share a similar pathogenesis. However, PTA may be disproportionate to the reduction in the GFR. Data relating to the mechanism of PTA are scarce. We evaluated the erythropoiesis parameters in pediatric kidney recipients compared to children with CKD. A total of 100 patients (54 post-kidney TX, 46 with CKD) were enrolled in the single-center cohort study. GFR was found to be significantly lower in the CKD group (49.7±22.4 vs 72.9±28.5 mL/min/1.73 m², P<.001); anemia was significantly more common in the TX patients (52% vs 41.3%, P<.001). Iron transferrin saturation and serum ferritin levels were lower in the CKD patients. In both groups, hemoglobin Z scores significantly correlated with GFR (R=.31, P=.07). This correlation was more prominent in the CKD group (R=.43, P=.008) compared to the TX group (R=.31, P=.04). Anemia was significantly more common in the TX patients than in the CKD patients despite a better GFR. The higher prevalence of anemia in the TX group could not be explained by an iron deficiency or reduced EPO production. We speculate that immunosuppressive therapy together with resistance to EPO may play a role in the pathogenesis of post-transplantation anemia.
Institute of Nephrology, Schneider Children's Medical Center of Israel, Petach Tikvah, Israel. iritk3@clalit.org.il.|Department of Pediatrics C, Schneider Children's Medical Center of Israel, Petach Tikvah, Israel. iritk3@clalit.org.il.|Sackler Faculty of Medicine Tel Aviv University, Ramat Aviv, Israel. iritk3@clalit.org.il.
Irit
I
Krause
Institute of Nephrology, Schneider Children's Medical Center of Israel, Petach Tikvah, Israel.|Sackler Faculty of Medicine Tel Aviv University, Ramat Aviv, Israel.
Miriam
M
Davidovits
Sackler Faculty of Medicine Tel Aviv University, Ramat Aviv, Israel.|Pediatric Hematology Unit, Schneider Children's Medical Center of Israel, Petach Tikvah, Israel.
Hannah
H
Tamary
Institute of Nephrology, Schneider Children's Medical Center of Israel, Petach Tikvah, Israel.
Maria
M
Yutcis
Institute of Nephrology, Schneider Children's Medical Center of Israel, Petach Tikvah, Israel.|Sackler Faculty of Medicine Tel Aviv University, Ramat Aviv, Israel.
Amit
A
Dagan
D000293:Adolescent; D000740:Anemia / Q000150:complications*; D002648:Child; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004920:Erythropoiesis / Q000502:physiology*; D005260:Female; D005293:Ferritins / Q000097:blood; D005919:Glomerular Filtration Rate; D006801:Humans; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007501:Iron / Q000097:blood; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D014168:Transferrin / Q000032:analysis; D055815:Young Adult
D007166:Immunosuppressive Agents; D014168:Transferrin; D005293:Ferritins; D007501:Iron
erythropoietin; iron; kidney graft; renal failure