Future Therapies in Burn Resuscitation.
Since the 1940s, the resuscitation of burn patients has evolved with dramatic improvements in mortality. The most significant achievement remains the creation and adoption of formulae to calculate estimated fluid requirements to guide resuscitation. Modalities to attenuate the hypermetabolic phase of injury include pharmacologic agents, early enteral nutrition, and the aggressive approach of early excision of large injuries. Recent investigations into the genomic response to severe burns and the application of computer-based decision support tools will likely guide future resuscitation, with the goal of further reducing mortality and morbidity, and improving functional and quality of life outcomes.
Division of Burns, Trauma, and Critical Care, Department of Surgery, University of Texas-Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9158, USA.
Erica I
EI
Hodgman
Division of Burns, Trauma, and Critical Care, Department of Surgery, University of Texas-Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9158, USA.
Madhu
M
Subramanian
Division of Burns, Trauma, and Critical Care, Department of Surgery, University of Texas-Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9158, USA.
Brett D
BD
Arnoldo
Division of Burns, Trauma, and Critical Care, Department of Surgery, University of Texas-Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9158, USA.
Herb A
HA
Phelan
Division of Burns, Trauma, and Critical Care, Department of Surgery, University of Texas-Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9158, USA. Electronic address: steven.wolf@utsouthwestern.edu.
Steven E
SE
Wolf
D002056:Burns / Q000503:physiopathology / Q000628:therapy*; D005440:Fluid Therapy / Q000379:methods* / Q000639:trends; D006801:Humans; D008991:Monitoring, Physiologic; D015532:Rehydration Solutions / Q000008:administration & dosage*; D012151:Resuscitation / Q000379:methods* / Q000639:trends
D015532:Rehydration Solutions
Burns; Fluid creep; Fluid resuscitation; Monitoring