Pediatric genetic diseases causing glaucoma.
Glaucomatous optic neuropathy may be considered as an endpoint of multiple systemic factors. Genetic conditions commonly causing glaucoma in children and adolescents include Axenfeld-Reiger syndrome, aniridia, Marfan syndrome, Weill-Marchessani syndrome, Sturge-Weber syndrome, Rubinstein-Taybi syndrome, nevus of Ota, congenital rubella and neurofibromatosis type 1. In the recent years, with the advancements in genetic research our understanding of the fundamental causes of glaucoma associated with inherited disorders has improved. In addition to intraocular pressure reduction, it is important for the clinician to be familiar with the multiple systemic associations with glaucoma, to re-evaluate treatment frequently, and to target the underlying disease process, if present.
Glaucoma Service, Department of Ophthalmology, Government Medical College and Hospital, Chandigarh, India.
Parul
P
Ichhpujani
Glaucoma Service, Department of Ophthalmology, Government Medical College and Hospital, Chandigarh, India.
Rohan B
RB
Singh
Axenfeld-Reiger syndrome; Marfan syndrome; Rubinstein-Taybi syndrome; Sturge-Weber syndrome; aniridia; childhood glaucoma; congenital rubella; neurofibromatosis type 1; nevus of Ota