Measurement of liver function using hepatobiliary scintigraphy improves risk assessment in patients undergoing major liver resection.
(99m)Tc-mebrofenin-hepatobiliary-scintigraphy (HBS) enables measurement of future remnant liver (FRL)-function and was implemented in our preoperative routine after calculation of the cut-off value for prediction of postoperative liver failure (LF). This study evaluates our results since the implementation of HBS. Additionally, CT-volumetric methods of FRL-assessment, standardized liver volumetry and FRL/body-weight ratio (FRL-BWR), were evaluated.



163 patients who underwent major liver resection were included. Insufficient FRL-volume and/or FRL-function <2.7%/min/m(2) were indications for portal vein embolization (PVE). Non-PVE patients were compared with a historical cohort (n = 55). Primary endpoints were postoperative LF and LF related mortality. Secondary endpoint was preoperative identification of patients at risk for LF using the CT-volumetric methods.



29/163 patients underwent PVE; 8/29 patients because of insufficient FRL-function despite sufficient FRL-volume. According to FRL-BWR and standardized liver volumetry, 16/29 and 11/29 patients, respectively, would not have undergone PVE. LF and LF related mortality were significantly reduced compared to the historical cohort. HBS appeared superior in the identification of patients with increased surgical risk compared to the CT-volumetric methods.



Implementation of HBS in the preoperative work-up led to a function oriented use of PVE and was associated with a significant decrease in postoperative LF and LF related mortality.
Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands. Electronic address: k.p.cieslak@amc.uva.nl.
Kasia P
KP
Cieslak
Department of Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands.
Roelof J
RJ
Bennink
Department of Gastroenterology & Hepatology, Erasmus Medical Center Rotterdam, The Netherlands.
Wilmar
W
de Graaf
Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands.
Krijn P
KP
van Lienden
Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands.
Marc G
MG
Besselink
Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands.
Olivier R C
OR
Busch
Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands.
Dirk J
DJ
Gouma
Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands. Electronic address: t.m.vangulik@amc.uva.nl.
Thomas M
TM
van Gulik
D000368:Aged; D000814:Aniline Compounds; D004621:Embolization, Therapeutic; D005260:Female; D005998:Glycine; D006498:Hepatectomy / Q000009:adverse effects; D006801:Humans; D007098:Imino Acids / Q000008:administration & dosage; D008099:Liver / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery*; D017093:Liver Failure / Q000209:etiology / Q000517:prevention & control; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D015609:Organotechnetium Compounds / Q000008:administration & dosage; D011169:Portal Vein / Q000000981:diagnostic imaging; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D012189:Retrospective Studies; D000072098:Single Photon Emission Computed Tomography Computed Tomography; D016896:Treatment Outcome
D000814:Aniline Compounds; D007098:Imino Acids; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C034837:technetium Tc 99m mebrofenin; D005998:Glycine