Comparison of global cerebral blood flow measured by phase-contrast mapping MRI with15O-H2O positron emission tomography.
To compare mean global cerebral blood flow (CBF) measured by phase-contrast mapping magnetic resonance imaging (PCM MRI) and by15O-H2O positron emission tomography (PET) in healthy subjects. PCM MRI is increasingly being used to measure mean global CBF, but has not been validated in vivo against an accepted reference technique.



Same-day measurements of CBF by15O-H2O PET and subsequently by PCM MRI were performed on 22 healthy young male volunteers. Global CBF by PET was determined by applying a one-tissue compartment model with measurement of the arterial input function. Flow was measured in the internal carotid and vertebral arteries by a noncardiac triggered PCM MRI sequence at 3T. The measured flow was normalized to total brain weight determined from a volume-segmented 3D T1-weighted anatomical MR-scan.



Mean CBF was 34.9 ± 3.4 mL/100 g/min measured by15O-H2O PET and 57.0 ± 6.8 mL/100 g/min measured by PCM MRI. The measurements were highly correlated (P = 0.0008, R2= 0.44), although values obtained by PCM MRI were higher compared to15O-H2O PET (absolute and relative differences were 22.0 ± 5.2 mL/100 g/min and 63.4 ± 14.8%, respectively).



This study confirms the use of PCM MRI for quantification of global CBF, but also that PCM MRI systematically yields higher values relative to15O-H2O PET, probably related to methodological bias.



3 J. Magn. Reson. Imaging 2017;45:692-699.
Functional Imaging Unit, Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital Rigshospitalet Glostrup, Glostrup, Denmark.
Mark Bitsch
MB
Vestergaard
Functional Imaging Unit, Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital Rigshospitalet Glostrup, Glostrup, Denmark.
Ulrich
U
Lindberg
Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Niels Jacob
NJ
Aachmann-Andersen
Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Kristian
K
Lisbjerg
Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Søren Just
SJ
Christensen
Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Peter
P
Rasmussen
Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.|Department of Neuroanaesthesia, Neuroscience Centre, Copenhagen University Hospital Rigshospitalet Blegdamsvej, Copenhagen, Denmark.
Niels Vidiendal
NV
Olsen
Institute for Clinical Medicine, The Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.|Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital Rigshospitalet Blegdamsvej, Copenhagen, Denmark.
Ian
I
Law
Functional Imaging Unit, Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital Rigshospitalet Glostrup, Glostrup, Denmark.|Institute for Clinical Medicine, The Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Henrik Bo Wiberg
HB
Larsson
Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital Rigshospitalet Blegdamsvej, Copenhagen, Denmark.
Otto Mølby
OM
Henriksen
D000293:Adolescent; D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology*; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D064847:Multimodal Imaging / Q000379:methods; D010100:Oxygen / Q000097:blood*; D010104:Oxygen Radioisotopes; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014867:Water; D055815:Young Adult
D010104:Oxygen Radioisotopes; C000615263:Oxygen-15; D019275:Radiopharmaceuticals; D014867:Water; D010100:Oxygen
cerebral blood flow; phase-contrast mapping; positron emission tomography