Balanced excitation and inhibition in temperature responses to meth.
Fatal hyperthermia after administration of various amphetamines is well-known clinical phenomenon, however, there is no consistent theory explaining its etiology and/or pathogenesis. Dose-dependence of temperature responses to methamphetamine is intricate. Recently, using mathematical modeling it was suggested that delicate interplay of excitatory and inhibitory mechanisms underlies this complexity.
Department of Mathematical Sciences; Indiana University - Purdue University Indianapolis ; Indianapolis, IN USA.
Yaroslav I
YI
Molkov
Department of Emergency Medicine; Indiana University School of Medicine , Indianapolis, IN USA.
Dmitry V
DV
Zaretsky
body temperature; methamphetamine; modeling; neural control