Management of knee osteoarthritis. Current status and future trends.
Osteoarthritis (OA) affects a large number of the population, and its incidence is showing a growing trend with the increasing life span. OA is the most prevalent joint condition worldwide, and currently, there is no functional cure for it. This review seeks to briefly overview the management of knee OA concerning standardized pharmaceutical and clinical approaches, as well as the new biotechnological horizons of OA treatment. The potential of biomaterials and state of the art of advanced therapeutic approaches, such as cell and gene therapy focused primarily on cartilage regeneration are the main subjects of this review. Biotechnol. Bioeng. 2017;114: 717-739. © 2016 Wiley Periodicals, Inc.
3B's Research Group-Biomaterials, Biodegradables and Biomimetics, Universidade do Minho, Headquarters of the European Institute Regenerative Medicine, AvePark 4806-909, Caldas das Taipas, Guimaraes, Portugal.|ICVS/3B's-PT Government Associated Laboratory, Braga/Guimaraes, Portugal.
Marta
M
Ondrésik
3B's Research Group-Biomaterials, Biodegradables and Biomimetics, Universidade do Minho, Headquarters of the European Institute Regenerative Medicine, AvePark 4806-909, Caldas das Taipas, Guimaraes, Portugal.|ICVS/3B's-PT Government Associated Laboratory, Braga/Guimaraes, Portugal.
Fatima R
FR
Azevedo Maia
3B's Research Group-Biomaterials, Biodegradables and Biomimetics, Universidade do Minho, Headquarters of the European Institute Regenerative Medicine, AvePark 4806-909, Caldas das Taipas, Guimaraes, Portugal.|ICVS/3B's-PT Government Associated Laboratory, Braga/Guimaraes, Portugal.|Stemmatters, Biotecnologia e Medicina Regenerativa SA, Guimaraes, Portugal.
Alain
A
da Silva Morais
3B's Research Group-Biomaterials, Biodegradables and Biomimetics, Universidade do Minho, Headquarters of the European Institute Regenerative Medicine, AvePark 4806-909, Caldas das Taipas, Guimaraes, Portugal.|ICVS/3B's-PT Government Associated Laboratory, Braga/Guimaraes, Portugal.|Stemmatters, Biotecnologia e Medicina Regenerativa SA, Guimaraes, Portugal.
Ana C
AC
Gertrudes
3B's Research Group-Biomaterials, Biodegradables and Biomimetics, Universidade do Minho, Headquarters of the European Institute Regenerative Medicine, AvePark 4806-909, Caldas das Taipas, Guimaraes, Portugal.|ICVS/3B's-PT Government Associated Laboratory, Braga/Guimaraes, Portugal.|Stemmatters, Biotecnologia e Medicina Regenerativa SA, Guimaraes, Portugal.
Ana H
AH
Dias Bacelar
3B's Research Group-Biomaterials, Biodegradables and Biomimetics, Universidade do Minho, Headquarters of the European Institute Regenerative Medicine, AvePark 4806-909, Caldas das Taipas, Guimaraes, Portugal.|ICVS/3B's-PT Government Associated Laboratory, Braga/Guimaraes, Portugal.|Stemmatters, Biotecnologia e Medicina Regenerativa SA, Guimaraes, Portugal.
Cristina
C
Correia
3B's Research Group-Biomaterials, Biodegradables and Biomimetics, Universidade do Minho, Headquarters of the European Institute Regenerative Medicine, AvePark 4806-909, Caldas das Taipas, Guimaraes, Portugal.|ICVS/3B's-PT Government Associated Laboratory, Braga/Guimaraes, Portugal.|Stemmatters, Biotecnologia e Medicina Regenerativa SA, Guimaraes, Portugal.
Cristiana
C
Gonçalves
3B's Research Group-Biomaterials, Biodegradables and Biomimetics, Universidade do Minho, Headquarters of the European Institute Regenerative Medicine, AvePark 4806-909, Caldas das Taipas, Guimaraes, Portugal.|ICVS/3B's-PT Government Associated Laboratory, Braga/Guimaraes, Portugal.|Stemmatters, Biotecnologia e Medicina Regenerativa SA, Guimaraes, Portugal.
Hajer
H
Radhouani
3B's Research Group-Biomaterials, Biodegradables and Biomimetics, Universidade do Minho, Headquarters of the European Institute Regenerative Medicine, AvePark 4806-909, Caldas das Taipas, Guimaraes, Portugal.|ICVS/3B's-PT Government Associated Laboratory, Braga/Guimaraes, Portugal.|Stemmatters, Biotecnologia e Medicina Regenerativa SA, Guimaraes, Portugal.
Rui
R
Amandi Sousa
3B's Research Group-Biomaterials, Biodegradables and Biomimetics, Universidade do Minho, Headquarters of the European Institute Regenerative Medicine, AvePark 4806-909, Caldas das Taipas, Guimaraes, Portugal.|ICVS/3B's-PT Government Associated Laboratory, Braga/Guimaraes, Portugal.
Joaquim M
JM
Oliveira
3B's Research Group-Biomaterials, Biodegradables and Biomimetics, Universidade do Minho, Headquarters of the European Institute Regenerative Medicine, AvePark 4806-909, Caldas das Taipas, Guimaraes, Portugal.|ICVS/3B's-PT Government Associated Laboratory, Braga/Guimaraes, Portugal.
Rui L
RL
Reis
D001672:Biocompatible Materials; D002358:Cartilage, Articular / Q000166:cytology / Q000502:physiology; D015316:Genetic Therapy; D006801:Humans; D020370:Osteoarthritis, Knee / Q000628:therapy*; D023822:Tissue Engineering
D001672:Biocompatible Materials
articular cartilage; biomaterials; gene therapy; osteoarthritis; regeneration; scaffolds; tissue engineering; viscosupplementation