Feasibility and applicability of diffusion-weighted and dynamic contrast-enhanced magnetic resonance imaging in routine assessments of children with high-grade gliomas.
Diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) have been used as imaging biomarkers in adults with high-grade gliomas (HGGs). We incorporated free-breathing DW-MRI and DCE-MRI, at a single time point, in the routine follow-up of five children (median age 9 years, range 8-15) with histologically confirmed HGG within a prospective imaging study. It was feasible to incorporate DW-MRI and DCE-MRI in routine assessments of children with HGG. DW and DCE parameters were repeatable in paediatric HGG. Higher median ADC100-1000significantly correlated with longer survival in our sample.
Paediatric & Adolescent Drug Development Team, Children & Young People's Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom.|Division of Clinical Studies and Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom.
Fernando
F
Carceller
Cancer Research UK Cancer Imaging Centre, The Institute of Cancer Research, London, United Kingdom.
Neil P
NP
Jerome
Cancer Research UK Cancer Imaging Centre, The Institute of Cancer Research, London, United Kingdom.
Keiko
K
Miyazaki
Cancer Research UK Cancer Imaging Centre, The Institute of Cancer Research, London, United Kingdom.
David J
DJ
Collins
Cancer Research UK Cancer Imaging Centre, The Institute of Cancer Research, London, United Kingdom.
Matthew R
MR
Orton
Cancer Research UK Cancer Imaging Centre, The Institute of Cancer Research, London, United Kingdom.
James A
JA
d'Arcy
Radiology Department, The Royal Marsden NHS Foundation Trust, London, United Kingdom.
Toni
T
Wallace
Paediatric & Adolescent Drug Development Team, Children & Young People's Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom.|Division of Clinical Studies and Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom.|Clinical Trials Unit, Paediatric Oncology Department, Hospital Niño Jesús, Madrid, Spain.
Lucas
L
Moreno
Paediatric & Adolescent Drug Development Team, Children & Young People's Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom.|Division of Clinical Studies and Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom.
Andrew D J
AD
Pearson
Paediatric & Adolescent Drug Development Team, Children & Young People's Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom.|Division of Clinical Studies and Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom.
Stergios
S
Zacharoulis
Cancer Research UK Cancer Imaging Centre, The Institute of Cancer Research, London, United Kingdom.
Martin O
MO
Leach
Paediatric & Adolescent Drug Development Team, Children & Young People's Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom.|Division of Clinical Studies and Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom.
Lynley V
LV
Marshall
Radiology Department, The Royal Marsden NHS Foundation Trust, London, United Kingdom.
Dow-Mu
DM
Koh
D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D002648:Child; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D005910:Glioma / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008297:Male; D060787:Neoplasm Grading; D011379:Prognosis; D055815:Young Adult
D003287:Contrast Media
diffusion-weighted; dynamic contrast-enhanced; functional imaging; high-grade glioma; magnetic resonance; paediatric