A Radical Break: Restraining Neutrophil Migration.
When neutrophils infiltrate a site of inflammation, they have to stop at the right place to exert their effector function. In this issue of Developmental Cell, Wang et al. (2016) show that neutrophils sense reactive oxygen species via the TRPM2 channel to arrest migration at their target site.
Institute of Science and Technology Austria (IST Austria), am Campus 1, 3400 Klosterneuburg, Austria.
Jörg
J
Renkawitz
Institute of Science and Technology Austria (IST Austria), am Campus 1, 3400 Klosterneuburg, Austria. Electronic address: sixt@ist.ac.at.
Michael
M
Sixt
D002465:Cell Movement / Q000235:genetics; D002634:Chemotaxis, Leukocyte / Q000235:genetics; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D009504:Neutrophils / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D050053:TRPM Cation Channels / Q000235:genetics / Q000378:metabolism*
D017382:Reactive Oxygen Species; D050053:TRPM Cation Channels; C121934:TRPM2 protein, human