A literature review of flavonoids and lifespan in model organisms.
Epidemiological data on consumption of flavonoid-containing food points to the notion that some of these secondary plant metabolites may favour healthy ageing. The aim of the present paper was to review the literature on lifespan extension by flavonoids in worms, flies and mice. In most studies, worms and flies experienced lifespan extension when supplemented with flavonoids either as extracts or single compounds. Studies with mutant worms and flies give hints as to which gene products may be regulated by flavonoids and consequently enhance longevity. We discuss the data considering putative mechanisms that may underlie flavonoid action such as energy-restriction-like effects, inhibition of insulin-like-growth-factor signalling, induction of antioxidant defence mechanisms, hormesis as well as antimicrobial properties. However, it remains uncertain whether human lifespan could be prolonged by increased flavonoid intake.
Institute of Human Nutrition and Food Science, University of Kiel,Germany.
Kathrin
K
Pallauf
Institute of Human Nutrition and Food Science, University of Kiel,Germany.
Nils
N
Duckstein
Institute of Human Nutrition and Food Science, University of Kiel,Germany.
Gerald
G
Rimbach
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology*; D017173:Caenorhabditis elegans / Q000187:drug effects; D019587:Dietary Supplements; D004331:Drosophila melanogaster / Q000187:drug effects; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D008136:Longevity / Q000187:drug effects*; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology
D000890:Anti-Infective Agents; D000975:Antioxidants; D005419:Flavonoids; D010936:Plant Extracts
 BE blueberry extract;  BTE black tea extract;  EGCG epigallocatechin gallate;  ER energy restriction;  FOXO forkhead box O;  GTE green tea extract;  IGF insulin-like growth factor;  PG pomegranate powder;  SOD superoxide dismutases; Catechin; Longevity; Polyphenols; Quercetin