Asymmetric aerobic oxidative NHC-catalysed synthesis of dihydropyranones utilising a system of electron transfer mediators.
In the context of green chemistry, the replacement of high molecular weight stoichiometric oxidants with O2 is most desirable but difficult. Here, we report the asymmetric aerobic oxidative synthesis of dihydropyranones. The oxidation is aided by a system of electron transfer mediators and is selective toward the homoenolate. The dihydropyranones can be isolated in high to excellent yields, with high ee (up to 95%).
Chemistry and Chemical Engineering, Chalmers University of Technology, Kemivägen 10 412 96 Göteborg, Sweden. sundenh@chalmers.se.
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Axelsson
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Hammarvid
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Sundén