Overweight and Weight Gain Predict Psoriasis Development in a Population-based Cohort.
Overweight is a proposed risk factor for psoriasis. How-ever, evidence from prospective studies is limited. The aim of this study was to investigate the association be-tween overweight, weight gain and risk of psoriasis, and potential synergism with smoking, within a population-based cohort including 8,752 individuals followed from 1994 up to 2008. There was a 32% increased odds of psoriasis from a body mass index (BMI) of 27 kg/m2, in multi-variable logistic regression analysis, further increasing to 43% at BMI 28 kg/m2, and to 71% at BMI ≥ 30 kg/m2 in non-smokers. There was a dose-response association between weight gain from age 25 years, with up to 90% higher odds of psoriasis from middle age, independent of weight category. There was no indication of a synergism between overweight and smoking, and no interaction with sex. Overweight and weight gain represent modifiable risk factors that may be targets for primary prevention of psoriasis.
Department of Dermatology, Neuro and Orthopedic Clinic, University Hospital of North Norway, 9038 Tromsø, Norway.
Kjersti
K
Danielsen
Tom
T
Wilsgaard
Anne Olaug
AO
Olsen
Anne-Sofie
AS
Furberg
D000328:Adult; D000368:Aged; D015992:Body Mass Index; D016009:Chi-Square Distribution; D005260:Female; D006306:Health Surveys; D006801:Humans; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009664:Norway; D016017:Odds Ratio; D050177:Overweight / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology / Q000517:prevention & control; D011446:Prospective Studies; D011565:Psoriasis / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D018570:Risk Assessment; D012307:Risk Factors; D040242:Risk Reduction Behavior; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects; D000074606:Smoking Prevention; D013997:Time Factors; D015430:Weight Gain