Meta-analysis of polymorphism rs6311 and rs6313 in the 5-HT2AR gene and schizophrenia.
BACKGROUND
rs6311 and rs6313 polymorphism of 5-hydroxytryptamine 2A receptor has been widely studied regarding association with susceptibility to schizophrenia, but the results remained inconsistent.


OBJECTIVE
This study aimed to assess the association between rs6311 and rs6313 polymorphism and schizophrenia using a meta-analysis.


METHODS
Pubmed, Web of Science, and Embase databases were searched for all articles linking rs6311 and rs6313 polymorphism and schizophrenia. All studies which met the inclusion and exclusion criteria were included in this meta-analysis. Pooled odds ratio and 95% confidence intervals were used to evaluate the association between rs6311 and rs6313 polymorphism and schizophrenia risk. Sub-group analysis was also performed by different ethnic studies (Asian and Caucasian) and different minor allelic studies (rs6311: minor allele = A and minor allele = G; rs6313: minor allele = T and minor allele = C).


RESULTS
Forty articles, including 50 case-control studies, were included in this meta-analysis. Specifically, 12 studies with 4100 cases and 4541 controls involved rs6311, 38 studies with 8960 cases and 9729 controls involved rs6313. The results showed that rs6311 and rs6313 were not associated with schizophrenia. Moreover, no associations were found between rs6311 and schizophrenia in different sub-groups, rs6313 was found to associated with schizophrenia among studies in which C is the minor allele.


CONCLUSIONS
This meta-analysis indicates that rs6311 and rs6313 polymorphisms of 5-HT2AR are not associated with schizophrenia. However, the rs6313 polymorphism is associated with schizophrenia in studies in which the minor allele is C.
a Department of Pharmacy , the Second Xiangya Hospital, Central South University , Changsha , PR China.|b Institute of Clinical Pharmacy , Central South University , Changsha , PR China.|c Department of Pharmacy , the Maternal and Child Health Hospital of Human Province , Changsha , PR China.
Li
L
Sun
a Department of Pharmacy , the Second Xiangya Hospital, Central South University , Changsha , PR China.|b Institute of Clinical Pharmacy , Central South University , Changsha , PR China.
Ping
P
Xu
a Department of Pharmacy , the Second Xiangya Hospital, Central South University , Changsha , PR China.|b Institute of Clinical Pharmacy , Central South University , Changsha , PR China.
Yan-Gang
YG
Zhou
d Center of Clinical Pharmacology and Pharmacy Department , the Third Xiangya Hospital, Central South University , Changsha , PR China.
Shan-Ru
SR
Zuo
a Department of Pharmacy , the Second Xiangya Hospital, Central South University , Changsha , PR China.|b Institute of Clinical Pharmacy , Central South University , Changsha , PR China.
Yi-Ping
YP
Liu
D006801:Humans; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
D044402:Receptor, Serotonin, 5-HT2A
5-HT2AR; meta-analysis; rs6311; rs6313; schizophrenia