blaOXA-48 carrying clonal colistin resistant-carbapenem resistant Klebsiella pneumoniae in neonate intensive care unit, India.
Bacteria resistant to colistin, a last resort antibiotic reflect the pre-antibiotic era. In this study, colistin resistance carbapenem-resistant K. pneumoniae (COLR- CRKP) strains from neonate's intensive care unit were evaluated. Molecular analysis showed that all the four colistin resistant K. pneumoniae isolates were clonally related with strong biofilm formation ability and harbored blaSHV-34and blaOXA-48genes. Our result suggested the need of proper surveillance and adequate infection control to limiting the spread of these organisms.
School of Biological Sciences, National Institute of Science Education and Research, Jatni, Odisha, India.
Santosh Kumar
SK
Singh
TATA Main Hospital, Jamshedpur, Jharkhand, India. Electronic address: guptaminakshitmh@gmail.com.
Minakshi
M
Gupta
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015780:Carbapenems / Q000494:pharmacology*; D016000:Cluster Analysis; D003091:Colistin / Q000494:pharmacology*; D003428:Cross Infection / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D005838:Genotype; D006801:Humans; D007194:India; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D007710:Klebsiella Infections / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000145:classification / Q000187:drug effects / Q000201:enzymology* / Q000302:isolation & purification; D058889:Molecular Typing; D001618:beta-Lactamases / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D015780:Carbapenems; D001618:beta-Lactamases; C108449:oxacillinase; D003091:Colistin
Colistin resistance; Klebsiella pneumoniae; Pandrug resistant