[Creutzfeldt-Jakob disease: Report of one case].
Creutzfeldt-Jakob disease has a higher incidence in Chile than in other countries. The post mortem pathological characterization of brain tissue is necessary to reach a definitive diagnosis. We report a 73 years old man with a history compatible with of a rapidly progressive dementia, in which the first electroencephalographic study showed a pattern consistent with non-convulsive status epilepticus. Besides discarding this diagnosis, it was necessary to rule out other causes of rapidly progressive dementia such as Hashimoto encephalopathy. Finally, the sustained clinical deterioration with no response to anticonvulsants and corticosteroids, the imaging studies, a serial electroencephalographic monitoring study and the detection of 14-3-3 protein in cerebrospinal fluid were the keys to achieve the diagnosis of the disease.
Departamento de Ciencias Neurológicas Oriente, Facultad de Medicina, Universidad de Chile, Santiago, Chile, marcosirp@hotmail.com.
Marcos
M
Ramírez
Departamento de Ciencias Neurológicas Oriente, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Andrés
A
Gallardo
Instituto de Neurocirugía Dr. Asenjo, Santiago, Chile.
Aarón
A
Vidal
Escuela de Postgrado, Universidad de Santiago de Chile, Santiago, Chile.
Sebastián
S
Cornejo
Servicio de Neurología, Hospital del Salvador, Santiago, Chile.
Darío
D
Ramírez
Biomedical Neuroscience Institute, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Danilo
D
Medinas
Servicio de Neurología, Hospital del Salvador, Santiago, Chile.
Gonzalo
G
Bustamante
Departamento de Ciencias Neurológicas Oriente, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Renzo
R
Pasquali
Biomedical Neuroscience Institute, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Claudio
C
Hetz
D048948:14-3-3 Proteins / Q000134:cerebrospinal fluid; D000368:Aged; D001344:Autopsy; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis*; D004569:Electroencephalography; D017809:Fatal Outcome; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male
D048948:14-3-3 Proteins