The Axon Protective Effects of Syringic Acid on Ischemia/Reperfusion Injury in a Rat Sciatic Nerve Model.
OBJECTIVE
In the relevant literature, there is no experimental study that investigated the axon protective effects of syringic acid- a polyphenol compound- with an anti-oxidant capacity on ischemia/reperfusion injury.


METHODS
The rats were randomly divided into four groups: Control group (no medication or surgical procedure), Sham group, Syringic acid group, and Methyprednisolone (MP) Group. Ischemia was achieved by abdominal aorta clamping and all animals were sacrificed 24 hours after ischemia. Harvested sciatic nerve segments were investigated histopathologically and for tissue biochemistry.


RESULTS
Ischemic fiber degeneration scores were found significantly lower in syringic acid and MP groups than sham group. Additionally, apoptosis-related cysteine peptidase caspase-3 immunostaining scores were lower in syringic acid and MP groups. Biochemically, superoxide dismutase and nuclear respiratory factor 1 values were significantly higher in syringic acid group compared to those of control and sham groups while malondialdehyde levels were significantly lower in the syringic acid group.


CONCLUSIONS
Syringic acid reduces oxidative stress and axonal degeneration in rat sciatic nerve after ischemia/reperfusion injury. Therefore, syringic acid may play a role in the treatment of peripheral nerve injuries due to ischemia/reperfusion.
Medipol University, Faculty of Medicine, Department of Neurosurgery, Istanbul, Turke.
Mehmet
M
Tokmak
Muserref Hilal
MH
Sehitoglu
Yasemin
Y
Yuksel
Mustafa
M
Guven
Tarik
T
Akman
Adem Bozkurt
AB
Aras
Umut
U
Yaka
Cengiz
C
Gomleksiz
Serdar Baki
SB
Albayrak
Murat
M
Cosar
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001369:Axons / Q000187:drug effects* / Q000473:pathology; D004195:Disease Models, Animal; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects; D059348:Peripheral Nerve Injuries / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control*; D011897:Random Allocation; D051381:Rats; D015427:Reperfusion Injury / Q000150:complications*; D012584:Sciatic Nerve / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology
D018696:Neuroprotective Agents; D005707:Gallic Acid; C001945:syringic acid