GAG mimetic functionalised solid and mesoporous silica nanoparticles as viral entry inhibitors of herpes simplex type 1 and type 2 viruses.
A glycosaminoglycan mimetic was attached to the surface of solid and mesoporous silica nanoparticles to create novel antiviral agents against herpes simplex type 1 and type 2 viruses. The nanoparticles act as viral entry inhibitors that appear to block viral attachment and penetration into susceptible cells.
The University of Queensland, School of Pharmacy, Brisbane, QLD 4072, Australia. b.ross1@uq.edu.au a.popat@uq.edu.au.
Edward C
EC
Lee
Nicholas
N
Davis-Poynter
Chau T H
CT
Nguyen
Amelia A
AA
Peters
Gregory R
GR
Monteith
Ekaterina
E
Strounina
Amirali
A
Popat
Benjamin P
BP
Ross
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001557:Benzenesulfonates; D002522:Chlorocebus aethiops; D006025:Glycosaminoglycans; D006561:Herpes Simplex; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D018258:Herpesvirus 2, Human / Q000187:drug effects*; D053758:Nanoparticles; D012822:Silicon Dioxide; D014709:Vero Cells; D010948:Viral Plaque Assay; D053586:Virus Internalization / Q000187:drug effects*
D000998:Antiviral Agents; D001557:Benzenesulfonates; D006025:Glycosaminoglycans; C032365:benzenesulfonic acid; D012822:Silicon Dioxide