Fabrication of electrospun polycaprolactone coated withchitosan-silver nanoparticles membranes for wound dressing applications.
In this study, electrospun polycaprolactone membrane coated with chitosan-silver nanoparticles (CsAg), electrospun polycaprolactone/chitosan/Ag nanoparticles, was fabricated by immersing the plasma-treated electrospun polycaprolactone membrane in the CsAg gel. The plasma modification of electrospun polycaprolactone membrane prior to CsAg coating was tested by methylene blue stain and scanning electron microscope. The presence of silver and chitosan on the plasma-treated electrospun polycaprolactone membrane was confirmed by energy-dispersive X-ray spectroscopy and FT-IR spectrum. Scanning electron microscope observation was employed to observe the morphology of the membranes. The release of Ag ions from electrospun polycaprolactone/chitosan/Ag nanoparticles membrane was tested using atomic absorption spectrometry. Electrospun polycaprolactone/chitosan/Ag nanoparticles membrane inherited advantages from both CsAg gel and electrospun polycaprolactone membrane such as: increasing biocompatibility, mechanical strength, and antibacterial activity against both Gram-negative and Gram-positive bacteria. Thus, this investigation introduces a highly potential membrane that can increase the efficacy of the wound dressing process.
Tissue Engineering and Regenerative Medicine Group, Department of Biomedical Engineering, International University, Vietnam National University-Ho Chi Minh City (VNU-HCM), HCMC, 700000, Vietnam.
Tra Thanh
TT
Nhi
Tissue Engineering and Regenerative Medicine Group, Department of Biomedical Engineering, International University, Vietnam National University-Ho Chi Minh City (VNU-HCM), HCMC, 700000, Vietnam.
Huynh Chan
HC
Khon
School of Biotechnology, International University, Vietnam National University-Ho Chi Minh City (VNU-HCM), HCMC, 700000, Vietnam.
Nguyen Thi Thu
NTT
Hoai
The Center for Molecular Biomedicine, University of Medicine and Pharmacy, HCMC, 700000, Vietnam.
Bui Chi
BC
Bao
Department - Materiasl and Pharmaceutical chemistry, Institute of Applied Materials Science-Vietnam Academy of Science and Technology, VAST, HCMC, 700000, Vietnam.
Tran Ngoc
TN
Quyen
Tissue Engineering and Regenerative Medicine Group, Department of Biomedical Engineering, International University, Vietnam National University-Ho Chi Minh City (VNU-HCM), HCMC, 700000, Vietnam.
Vo
V
Van Toi
Tissue Engineering and Regenerative Medicine Group, Department of Biomedical Engineering, International University, Vietnam National University-Ho Chi Minh City (VNU-HCM), HCMC, 700000, Vietnam. nthiep@hcmiu.edu.vn.
Nguyen Thi
NT
Hiep
D000535:Aluminum / Q000737:chemistry; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry; D047070:Bandages, Hydrocolloid; D001672:Biocompatible Materials / Q000737:chemistry; D002460:Cell Line; D048271:Chitosan / Q000737:chemistry*; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D007477:Ions; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D008855:Microscopy, Electron, Scanning; D011091:Polyesters / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D013052:Spectrometry, X-Ray Emission; D017550:Spectroscopy, Fourier Transform Infrared; D013314:Stress, Mechanical; D013718:Tensile Strength; D014867:Water / Q000737:chemistry; D014945:Wound Healing
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D007477:Ions; D011091:Polyesters; D014867:Water; C016240:polycaprolactone; D012834:Silver; D048271:Chitosan; D000535:Aluminum