[Stereotactic body radiation therapy for spinal metastases].
After the liver and lungs, bones are the third most common sites of cancer metastasis. Palliative radiotherapy for secondary bone tumours helps relieve pain, improve the quality of life and reduce the risk of fractures. Stereotactic body radiotherapy can deliver high radiation doses with very tight margins, which has significant advantages when treating tumours close to the spinal cord. Strict quality control is essential as dose gradient at the edge of the spinal cord is important. Optimal schedule is not defined. A range of dose-fractionation schedules have been used. Pain relief and local control are seen in over 80%. Toxicity rates are low, although vertebral fracture may occur. Ongoing prospective studies will help clarify its role in the management of oligometastatic patients.
Département universitaire de radiothérapie, centre Oscar-Lambret, 3, rue Frédéric-Combemale, 59020 Lille, France; CNRS UMR 9189, centre de recherche en informatique, signal et automatique de Lille : Cristal, université de Lille, bâtiment M3 extension, avenue Carl-Gauss, 59655 Villeneuve-d'Ascq cedex, France. Electronic address: d-pasquier@o-lambret.fr.
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Pasquier
Département universitaire de radiothérapie, centre Oscar-Lambret, 3, rue Frédéric-Combemale, 59020 Lille, France.
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Martinage
Département universitaire de radiothérapie, centre Oscar-Lambret, 3, rue Frédéric-Combemale, 59020 Lille, France.
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Mirabel
Département universitaire de radiothérapie, centre Oscar-Lambret, 3, rue Frédéric-Combemale, 59020 Lille, France.
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Lacornerie
Département universitaire de radiothérapie, centre Oscar-Lambret, 3, rue Frédéric-Combemale, 59020 Lille, France.
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Makhloufi
Département universitaire de radiothérapie-curiethérapie, institut de cancérologie de Lorraine Alexis-Vautrin, 6, avenue de Bourgogne, 54519 Vandœuvre-lès-Nancy, France.
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Faivre
Département de radiothérapie, centre Henri-Becquerel, rue d'Amiens, 76000 Rouen, France.
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Thureau
Département universitaire de radiothérapie, centre Oscar-Lambret, 3, rue Frédéric-Combemale, 59020 Lille, France; CNRS UMR 9189, centre de recherche en informatique, signal et automatique de Lille : Cristal, université de Lille, bâtiment M3 extension, avenue Carl-Gauss, 59655 Villeneuve-d'Ascq cedex, France.
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Lartigau
D001416:Back Pain / Q000209:etiology / Q000628:therapy*; D006801:Humans; D058958:Organs at Risk; D016634:Radiosurgery; D011879:Radiotherapy Dosage; D013125:Spinal Neoplasms / Q000532:radiotherapy* / Q000556:secondary*
Hypofractionation; Hypofractionnement; Métastases vertébrales; Oligometastasis; Oligométastases; Radiothérapie stéréotaxique; Spinal metastases; Stereotactic radiotherapy