MicroRNAs in acute kidney injury.
Acute kidney injury (AKI) is an important clinical issue that is associated with significant morbidity and mortality. Despite research advances over the past decades, the complex pathophysiology of AKI is not fully understood. The regulatory mechanisms underlying post-AKI repair and fibrosis have not been clarified either. Furthermore, there is no definitively effective treatment for AKI. MicroRNAs (miRNAs) are endogenous single-stranded noncoding RNAs of 19~23 nucleotides that have been shown to be crucial to the post-transcriptional regulation of various cellular biological functions, including proliferation, differentiation, metabolism, and apoptosis. In addition to being fundamental to normal development and physiology, miRNAs also play important roles in various human diseases. In AKI, some miRNAs appear to act pathogenically by promoting inflammation, apoptosis, and fibrosis, while others may act protectively by exerting anti-inflammatory, anti-apoptotic, anti-fibrotic, and pro-angiogenic effects. Thus, miRNAs have not only emerged as novel biomarkers for AKI; they also hold promise to be potential therapeutic targets.
Kidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.|Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan.
Pei-Chun
PC
Fan
Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan.
Chia-Chun
CC
Chen
Kidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.
Yung-Chang
YC
Chen
Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan.
Yu-Sun
YS
Chang
Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taipei, Taiwan. taipei.chu@gmail.com.|Healthcare Center, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taipei, Taiwan. taipei.chu@gmail.com.|Heart Failure Center, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taipei, Taiwan. taipei.chu@gmail.com.|Department of Cardiology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, 199 Tung Hwa North Road, Taipei, 105, Taiwan. taipei.chu@gmail.com.
Pao-Hsien
0000-0003-0361-6348
PH
Chu
D058186:Acute Kidney Injury / Q000175:diagnosis / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D015870:Gene Expression; D005786:Gene Expression Regulation; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism
D015415:Biomarkers; D035683:MicroRNAs
Acute kidney injury; MicroRNAs; Renal fibrosis