Progression of temporal processing deficits in the HIV-1 transgenic rat.
The HIV-1 transgenic (Tg) rat, which expresses 7 of the 9 HIV-1 genes, was used to investigate the effect(s) of long-term HIV-1 viral protein exposure on chronic neurocognitive deficits observed in pediatric HIV-1 (PHIV). A longitudinal experimental design was used to assess the progression of temporal processing deficits, a potential underlying dimension of neurocognitive impairment in HIV-1. Gap prepulse inhibition (gap-PPI), a translational experimental paradigm, was conducted every thirty days from postnatal day (PD) 30 to PD 180. HIV-1 Tg animals, regardless of sex, displayed profound alterations in the development of temporal processing, assessed using prepulse inhibition. A differential sensitivity to the manipulation of interstimulus interval was observed in HIV-1 Tg animals in comparison to control animals. Moreover, presence of the HIV-1 transgene was diagnosed with 90.8% accuracy using measures of prepulse inhibition and temporal sensitivity. Progression of temporal processing deficits in the HIV-1 Tg rat affords a relatively untapped opportunity to increase our mechanistic understanding of the role of long-term exposure to HIV-1 viral proteins, observed in pediatric HIV-1, in the development of chronic neurological impairment, as well as suggesting an innovative clinical diagnostic screening tool.
Program in Behavioral Neuroscience Department of Psychology University of South Carolina Columbia, SC 29208, USA.
Kristen A
KA
McLaurin
Program in Behavioral Neuroscience Department of Psychology University of South Carolina Columbia, SC 29208, USA.
Rosemarie M
RM
Booze
Program in Behavioral Neuroscience Department of Psychology University of South Carolina Columbia, SC 29208, USA.
Charles F
CF
Mactutus
D000161:Acoustic Stimulation; D000818:Animals; D001307:Auditory Perception / Q000502:physiology*; D015658:HIV Infections / Q000503:physiopathology* / Q000821:virology; D015497:HIV-1 / Q000502:physiology*; D008297:Male; D065808:Prepulse Inhibition / Q000502:physiology*; D051381:Rats; D011916:Rats, Inbred F344; D055647:Rats, Transgenic; D055139:Sensory Gating / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*