[Nitroxoline - an option for the antibiotic treatment of urinary tract infections].
BACKGROUND
Resistance of uropathogenic bacteria against the common antibiotics is considerable-especially in the elderly.


OBJECTIVE
In Germany nitroxoline is licensed for the treatment of acute urinary tract infections and for prophylaxis of recurrent infections. What is the actual resistance pattern of uropathogenic bacteria?


METHODS
The in vitro susceptibility of 477 uropathogenic bacteria from patients in 2015 was determined by means of the agar diffusion method.


RESULTS
Obviously, this agent is still active against the vast majority of uropathogenic bacteria and in particular against strains of Escherichia coli (E. coli). Pseudomonas aeruginosa and enterococci are not really within the spectrum of nitroxoline. One has to keep in mind, however, that even among E. coli and other enterobacteriaceae there are single resistant isolates. This applies in particular to problem strains resistant to many other antibiotics.


CONCLUSIONS
Nitroxoline is a reasonable alternative and a promising option for calculated treatment of urinary tract infections-especially of the elderly, although this drug is not recommended in the current guideline. Laboratory testing of clinical isolates should be requested-at least when treatment fails.
MVZ Labor Limbach, Im Breitspiel 15, 69126, Heidelberg, Deutschland. herbert.hof@labor-limbach.de.
H
H
Hof
MVZ Labor Limbach, Im Breitspiel 15, 69126, Heidelberg, Deutschland.
D
D
Bertsch
Praxis für Urologie, Hanau, Deutschland.
D
D
Passek
MVZ Labor Limbach, Im Breitspiel 15, 69126, Heidelberg, Deutschland.
R
R
Schwarz
D000293:Adolescent; D000328:Adult; D000368:Aged; D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage; D001419:Bacteria / Q000145:classification / Q000187:drug effects*; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology*; D006801:Humans; D008875:Middle Aged; D009600:Nitroquinolines / Q000008:administration & dosage*; D016896:Treatment Outcome; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology*; D055815:Young Adult
D000892:Anti-Infective Agents, Urinary; D009600:Nitroquinolines; C005308:nitroxoline
Enterobacteriaceae; Escherichia coli; Multiresistant strains; Pseudomonas aeruginosa; Uropathogenic bacteria