Weight loss and decubitus duodenal ulcer in Parkinson's disease treated with levodopa-carbidopa intestinal gel infusion.
Apparently, unexplained weight loss is a common symptom experienced by patients affected by Parkinson's disease, especially in those treated by levodopa-carbidopa infusion gel (LCIG) with a poor control of dyskinesias. Weight loss is considered part of gastrointestinal dysfunction seen in patients affected by Parkinson's disease, along with gastroparesis and reduced bowel peristalsis. In patients treated with LCIG, weight loss needs to be accurately evaluated, because of possible underlying life-threatening adverse events, like duodenum decubitus ulcer.
SC Neurologia Universitaria-AOU Ospedali Riuniti of Foggia, Foggia, Italy. tommartin@hotmail.it.
Tommaso
http://orcid.org/0000-0001-8877-4104
T
Martino
SC Neurologia Universitaria-AOU Ospedali Riuniti of Foggia, Foggia, Italy.
Donato
D
Melchionda
Gastroenterology Unit-AOU Ospedali Riuniti of Foggia, Foggia, Italy.
Paolo
P
Tonti
Gastroenterology Unit-AOU Ospedali Riuniti of Foggia, Foggia, Italy.
Vincenzo
V
De Francesco
SC Neurologia Universitaria-AOU Ospedali Riuniti of Foggia, Foggia, Italy.
Alessandra
A
Lalla
SC Neurologia Universitaria-AOU Ospedali Riuniti of Foggia, Foggia, Italy.
Luigi Maria
LM
Specchio
SC Neurologia Universitaria-AOU Ospedali Riuniti of Foggia, Foggia, Italy.
Carlo
C
Avolio
D000368:Aged; D000978:Antiparkinson Agents / Q000009:adverse effects*; D002230:Carbidopa / Q000009:adverse effects*; D004338:Drug Combinations; D004381:Duodenal Ulcer / Q000000981:diagnostic imaging / Q000209:etiology*; D004386:Duodenum / Q000000981:diagnostic imaging / Q000502:physiology*; D020820:Dyskinesias / Q000209:etiology; D020776:Endoscopes, Gastrointestinal; D006801:Humans; D007980:Levodopa / Q000009:adverse effects*; D008297:Male; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed; D015431:Weight Loss / Q000187:drug effects*
D000978:Antiparkinson Agents; D004338:Drug Combinations; C009265:carbidopa, levodopa drug combination; D007980:Levodopa; D002230:Carbidopa
Duodenal decubitus ulcer; Intestinal levodopa infusion; Parkinson’s disease