Food Fight: Role of Itaconate and Other Metabolites in Antimicrobial Defense.
Itaconate is a newly discovered mammalian metabolite bearing significant implications for our understanding of cellular immunometabolism and antimicrobial defense. Here, we explore recent findings regarding the role of itaconate in the innate immune response and highlight the emerging principle that metabolites can have distinct immunological functions independent of bioenergetics.
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Harding H
HH
Luan
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: ruslan.medzhitov@yale.edu.
Ruslan
R
Medzhitov
D000890:Anti-Infective Agents / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects; D005502:Food; D007109:Immunity / Q000187:drug effects; D007249:Inflammation / Q000473:pathology; D055442:Metabolome / Q000187:drug effects*; D013386:Succinates / Q000494:pharmacology*
D000890:Anti-Infective Agents; D013386:Succinates; C005229:itaconic acid