Genotype Distribution of Human Papillomavirus among Women with Cervical Cytological Abnormalities or Invasive Squamous Cell Carcinoma in a High-Incidence Area of Esophageal Carcinoma in China.
Data of HPV genotype including 16 high-risk HPV (HR-HPV) and 4 low-risk HPV from 38,397 women with normal cytology, 1341 women with cervical cytology abnormalities, and 223 women with ISCC were retrospectively evaluated by a hospital-based study. The prevalence of high-risk HPV (HR-HPV) was 6.51%, 41.83%, and 96.86% in women with normal cytology, cervical cytology abnormalities, and ISCC, respectively. The three most common HPV types were HPV-52 (1.76%), HPV-16 (1.28%), and HPV-58 (0.97%) in women with normal cytology, whereas the most prevalent HPV type was HPV-16 (16.85%), followed by HPV-52 (9.55%) and HPV-58 (7.83%) in women with cervical cytology abnormalities. Specifically, HPV-16 had the highest frequency in ASC-H (24.16%, 36/149) and HSIL (35.71%, 110/308), while HPV-52 was the most common type in ASC-US (8.28%, 53/640) and LSIL (16.80%, 41/244). HPV-16 (75.78%), HPV18 (10.31%), and HPV58 (9.87%) were the most common types in women with ISCC. These data might contribute to increasing the knowledge of HPV epidemiology and providing the guide for vaccine selection for women in Shantou.
Department of Pathology, Shantou Central Hospital and the Affiliated Shantou Hospital of Sun Yat-Sen University, Shantou, Guangdong 515041, China.
Yuanyuan
Y
Wang
Department of Pathology, Shantou Central Hospital and the Affiliated Shantou Hospital of Sun Yat-Sen University, Shantou, Guangdong 515041, China.
Shaohong
S
Wang
Department of Pathology, Shantou Central Hospital and the Affiliated Shantou Hospital of Sun Yat-Sen University, Shantou, Guangdong 515041, China.
Jinhui
J
Shen
Department of Laboratory Medicine, Shantou Central Hospital and the Affiliated Shantou Hospital of Sun Yat-Sen University, Shantou, Guangdong 515041, China.
Yanyan
Y
Peng
Department of Laboratory Medicine, Shantou Central Hospital and the Affiliated Shantou Hospital of Sun Yat-Sen University, Shantou, Guangdong 515041, China.
Lechuan
L
Chen
Department of Laboratory Medicine, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, China.
Ruiqin
R
Mai
Department of Pathology, Shantou University Medical College, Shantou, Guangdong 515041, China.
Guohong
0000-0002-3856-3111
G
Zhang
D000368:Aged; D052685:Alphapapillomavirus / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000821:virology; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000821:virology; D005260:Female; D005838:Genotype; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000821:virology