Engineering the Ionic Self-Assembly of Polyoxometalates and Facial-Like Peptides.
The self-assembly behavior of polyoxometalates (PMs) and facial-like cationic peptides carrying lysine residues were systematically investigated. Circular dichroism and UV/Vis spectra demonstrated that the multivalent electrostatic attractions between polyanionic PMs and short peptides with protonated lysine residues initiated the conformational transition of peptide molecules from random-coil to β-sheet state, and subsequently the co-assembly. TEM and atomic force microscopy (AFM) measurements showed that uniform nanofibers formed with decreasing size of the PMs or increasing the intermolecular forces of the peptides, such as through hydrogen-bonding, hydrophobic, and/or π-π interactions. Additionally, the stability of the nanostructures can be improved by rational suppression of the electrostatic repulsion of the shell peptides covering the surface of the nanostructures. These results provide new insight into understanding the ionic self-assembly of peptides and PMs and controlling their final morphology.
State Key Laboratory of Supramolecular Structure and Materials, Institute of Theoretical Chemistry, Jilin University, Qianjin Avenue 2699, Changchun, 130012, P.R. China.
Jingfang
J
Li
State Key Laboratory of Supramolecular Structure and Materials, Institute of Theoretical Chemistry, Jilin University, Qianjin Avenue 2699, Changchun, 130012, P.R. China.
Xiaodong
X
Li
State Key Laboratory of Supramolecular Structure and Materials, Institute of Theoretical Chemistry, Jilin University, Qianjin Avenue 2699, Changchun, 130012, P.R. China.
Jing
J
Xu
State Key Laboratory of Supramolecular Structure and Materials, Institute of Theoretical Chemistry, Jilin University, Qianjin Avenue 2699, Changchun, 130012, P.R. China.
Yang
Y
Wang
State Key Laboratory of Supramolecular Structure and Materials, Institute of Theoretical Chemistry, Jilin University, Qianjin Avenue 2699, Changchun, 130012, P.R. China.
Lixin
L
Wu
State Key Laboratory of Supramolecular Structure and Materials, Institute of Theoretical Chemistry, Jilin University, Qianjin Avenue 2699, Changchun, 130012, P.R. China.
Yanqiu
Y
Wang
State Key Laboratory of Supramolecular Structure and Materials, Institute of Theoretical Chemistry, Jilin University, Qianjin Avenue 2699, Changchun, 130012, P.R. China.
Liyan
L
Wang
State Key Laboratory of Supramolecular Structure and Materials, Institute of Theoretical Chemistry, Jilin University, Qianjin Avenue 2699, Changchun, 130012, P.R. China.
Myongsoo
M
Lee
State Key Laboratory of Supramolecular Structure and Materials, Institute of Theoretical Chemistry, Jilin University, Qianjin Avenue 2699, Changchun, 130012, P.R. China. wenli@jlu.edu.cn.
Wen
W
Li
D002942:Circular Dichroism; D006860:Hydrogen Bonding; D057927:Hydrophobic and Hydrophilic Interactions; D007477:Ions; D018625:Microscopy, Atomic Force; D057139:Nanofibers / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D055672:Static Electricity; D017973:Tungsten Compounds / Q000737:chemistry*; D000099294:Polyoxometalates
D007477:Ions; D010455:Peptides; D017973:Tungsten Compounds; C102296:polyoxometalate I; D000099294:Polyoxometalates
cationic peptides; multivalent interactions; polyoxometalates; self-assembly morphology