Mitochondrial Transfer from Astrocytes to Neurons following Ischemic Insult: Guilt by Association?
Intercellular mitochondrial transfer has been shown in tumor models, following lung injury and in xenotransplants of leukemic cells, but trafficking between cells in the brain remains unexplored. A suggestion that mitochondria move from astrocytes to neurons in a model of ischemia in a recent article in Nature by Hayakawa et al. (2016) should be interpreted with caution.
Malaghan Institute of Medical Research, Wellington 6012, New Zealand. Electronic address: mberridge@malaghan.org.nz.
Michael V
MV
Berridge
Malaghan Institute of Medical Research, Wellington 6012, New Zealand; Victoria University of Wellington, Wellington 6140, New Zealand.
Remy T
RT
Schneider
Victoria University of Wellington, Wellington 6140, New Zealand.
Melanie J
MJ
McConnell
D001253:Astrocytes; D001921:Brain; D002545:Brain Ischemia; D006167:Guilt; D006801:Humans; D008928:Mitochondria; D009474:Neurons