Pretreatment lymphocyte-to-monocyte ratio as an independent prognostic factor for head and neck cancer.
The purpose of this study was to analyze the relationship between pretreatment inflammatory markers and the prognosis of patients with oropharyngeal, hypopharyngeal, and laryngeal cancers.



The data for 285 patients treated with curative intent by concurrent chemoradiotherapy (CRT) were obtained and their pretreatment inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) were calculated.



Significant relationships were observed between a high NLR and oropharyngeal or hypopharyngeal cancer, T3 to T4, N2b to N3, and clinical stage III to IV, whereas significant relationships were observed between a high LMR and laryngeal cancer, T1 to T2, and clinical stage I to II. With regard to survival outcomes, a high NLR, a high PLR, and a low LMR were all significantly associated with decreases in overall survival (OS) and disease-free survival (DFS). Furthermore, multivariate analysis showed that LMR was an independent prognostic factor.



Pretreatment LMR was found to be an independent prognostic factor for patients with head and neck cancers treated by concurrent CRT. © 2016 Wiley Periodicals, Inc. Head Neck 39: 247-253, 2017.
Department of Otolaryngology - Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Satoshi
S
Kano
Department of Otolaryngology - Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Akihiro
A
Homma
Department of Otolaryngology - Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Hiromitsu
H
Hatakeyama
Department of Otolaryngology - Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Takatsugu
T
Mizumachi
Department of Otolaryngology - Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Tomohiro
T
Sakashita
Department of Otolaryngology - Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Tomohiko
T
Kakizaki
Department of Otolaryngology - Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Satoshi
S
Fukuda
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D059248:Chemoradiotherapy / Q000379:methods*; D015331:Cohort Studies; D016208:Databases, Factual; D018572:Disease-Free Survival; D005260:Female; D006258:Head and Neck Neoplasms / Q000097:blood* / Q000401:mortality* / Q000628:therapy; D006785:Hospitals, University; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000097:blood / Q000401:mortality / Q000628:therapy; D018836:Inflammation Mediators / Q000097:blood*; D007564:Japan; D053208:Kaplan-Meier Estimate; D007822:Laryngeal Neoplasms / Q000097:blood / Q000401:mortality / Q000628:therapy; D007825:Laryngectomy / Q000379:methods*; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000166:cytology; D037981:Neck Dissection / Q000379:methods; D009959:Oropharyngeal Neoplasms / Q000097:blood / Q000401:mortality / Q000628:therapy; D010976:Platelet Count; D011300:Preoperative Care / Q000379:methods; D016016:Proportional Hazards Models; D012372:ROC Curve; D012189:Retrospective Studies; D016019:Survival Analysis
D018836:Inflammation Mediators
chemoradiotherapy; head and neck cancer; lymphocyte-to-monocyte ratio (LMR); neutrophil-to-lymphocyte ratio (NLR); platelet-to-lymphocyte ratio (PLR)