Layer-by-Layer Encapsulation of Probiotics for Delivery to the Microbiome.
The gastrointestinal (GI) microbiome is widely investigated for its role in many diseases. However, technologies designed for microbiome delivery are lacking. Here, a layer-by-layer (LbL) approach is reported for probiotic encapsulation to protect probiotics against GI tract insults and improve their adhesion and growth on the intestines. These advantages translate to significantly enhanced survival of LbL-probiotics in vivo.
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA, 02139, USA.
Aaron C
AC
Anselmo
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA, 02139, USA.
Kevin J
KJ
McHugh
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA, 02139, USA.
Jamie
J
Webster
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA, 02139, USA.
Robert
R
Langer
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA, 02139, USA.
Ana
A
Jaklenec
D000818:Animals; D000070000:Bacillus coagulans / Q000166:cytology / Q000254:growth & development / Q000302:isolation & purification / Q000378:metabolism; D001422:Bacterial Adhesion; D001647:Bile Acids and Salts / Q000378:metabolism / Q000494:pharmacology; D004339:Drug Compounding; D000069196:Gastrointestinal Microbiome / Q000502:physiology; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000187:drug effects / Q000382:microbiology; D019936:Probiotics / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D013552:Swine
D001647:Bile Acids and Salts
biomaterials; gastrointestinal tract; microbiome; oral delivery