Primary splenic B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma: A case report.
B-cell lymphoma (BCL), unclassifiable, with features intermediate between diffuse large BCL (DLBCL) and classical Hodgkin's lymphoma (CHL), is a novel entity to the World Health Organization classification system. These tumors are rare aggressive lymphomas that have a poor prognosis. The present study reports the case of a patient with one such lymphoma that occurred in the spleen, which expressed cluster of differentiation (CD)20, CD79α, melanoma associated antigen (mutated) 1, BCL6, CD15 and CD30. Polymerase chain reaction analysis demonstrated a clonal rearrangement of the genes coding for immunoglobulin heavy chains. The tumor cells demonstrated a negative reaction in the Epstein-Barr virus-encoded small RNA assay. Following the diagnosis of unclassifiable BCL, with intermediate features between DLBCL and CHL, the patient received 7 cycles of the CHOP regimen, and so far, has been in good general condition and tumor-free for 17 months.
Department of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China.
Feng
F
Shi
Department of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China.
Quan
Q
Zhou
Department of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China.
Ying
Y
Gao
Department of Pathology, Pu Ren Hospital, Beijing 100062, P.R. China.
Xiang-Qing
XQ
Cui
Department of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China.
Hong
H
Chang
B-cell lymphoma; gray zone; lymphoma; spleen; unclassifiable