[Main manifestations of the phenomenon of remote post-conditioning of the heart. Clinical application of post-conditioning].
It was determined that remote post-conditioning (RP) exerts infarction-limiting and antiapoptotic effects. The infarction-limiting effect of RP is associated with enhancement of autophagia of cardiomyocytes. It was determined that RP may be an effective method of preventing reperfusion contractile dysfunction of the heart. The problem of whether RP exerts an antiarrhythmic effect in cardiac ischaemia-reperfusion remains unsolved as yet. Limitation of leukocytic invasion may have direct relation to the cardioprotector effect of RP. Decreasing the level of anti-inflammatory cytokines and MCP-1 chemokine may contribute to limitation of leukocytic infiltration into the reperfusion zone. It was determined that RP provides a decrease in intensity of lipid peroxidation. Remote postconditioning prevents reperfusion damage to cardiomyocytes both in children and adults, but RP does not improve the clinical course of the postoperative period in patients with coronary bypass grafting. In children, RP improves the course of the postoperative period. What is the reason of such difference between children and adults remains unknown. It was shown that RP exerts an infarction-limiting effect in transcutaneous coronary interventions in patients with ST elevation myocardial infarction.
Scientific Research Institute of Cardiology, Tomsk, Russia.
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Maslov
D000328:Adult; D000367:Age Factors; D002648:Child; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D057775:Ischemic Postconditioning / Q000379:methods*; D019157:Ischemic Preconditioning, Myocardial / Q000379:methods; D009203:Myocardial Infarction / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D032383:Myocytes, Cardiac / Q000502:physiology; D020556:Neutrophil Infiltration / Q000502:physiology; D065840:Protective Factors
D016207:Cytokines