Dendrimers as Innovative Radiopharmaceuticals in Cancer Radionanotherapy.
Radiotherapy is one of the most commonly used cancer treatments, with an estimate of 40% success that could be improved further if more efficient targeting and retention of radiation at the tumor site were achieved. This review focuses on the use of dendrimers in radionanotherapy, an emerging technology aimed to improve the efficiency of radiotherapy by implementing nanovectorization, an already established praxis in drug delivery and diagnosis. The labeling of dendrimers with radionuclides also aims to reduce the dose of radiolabeled materials and, hence, their toxicity and tumor resistance. Examples of radiolabeled dendrimers with alpha, beta, and Auger electron emitters are commented, along with the use of dendrimers in boron neutron capture therapy (BNCT). The conjugation of radiolabeled dendrimers to monoclonal antibodies for a more efficient targeting and the application of dendrimers in gene delivery radiotherapy are also covered.
INSERM U 1066, 'Micro et Nanomédecines biomimétiques - MINT', and Plateforme de Radiobiologie et d'IMagerie EXpérimentale, PRIMEX, SFR ICAT 4208, Université Angers, UMR-S1066, 49933 Angers, Cedex 9, France.|Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela , Jenaro de la Fuente s/n, 15782 Santiago de Compostela, Spain.
Flonja
F
Liko
INSERM U 1066, 'Micro et Nanomédecines biomimétiques - MINT', and Plateforme de Radiobiologie et d'IMagerie EXpérimentale, PRIMEX, SFR ICAT 4208, Université Angers, UMR-S1066, 49933 Angers, Cedex 9, France.
François
F
Hindré
Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela , Jenaro de la Fuente s/n, 15782 Santiago de Compostela, Spain.
Eduardo
E
Fernandez-Megia
D016754:Boron Neutron Capture Therapy; D050091:Dendrimers / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D006801:Humans; D050997:Nanomedicine; D009369:Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D019275:Radiopharmaceuticals / Q000737:chemistry / Q000627:therapeutic use*
D050091:Dendrimers; D019275:Radiopharmaceuticals