Visual pathway abnormalities in tuberculous meningitis.
Ophthalmological complications are common and disabling in patients with tuberculous meningitis. We aimed to study the visual pathway abnormalities in patients with tuberculous meningitis. Forty-three patients with tuberculous meningitis were subjected to visual evoked responses (VER) and neuroophthalmologic assessment. Neuroophthalmologic assessment revealed abnormalities in 22 (51.3%) patients. VER were found to be abnormal in 27 (62.8%) patients. The VER abnormalities included prolonged P100 latencies with relatively normal amplitude and significant interocular latency differences. Visual pathways abnormalities are common in patients with tuberculous meningitis and are often subclinical. Pathophysiologic explanations for electrophysiological abnormalities on VER in these patients are incompletely understood and needs further exploration.
Department of Neurology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Vibhuti Khand, Gomti Nagar, Lucknow, Uttar Pradesh 226010, India.
Pradeep Kumar
PK
Maurya
Department of Neurology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Vibhuti Khand, Gomti Nagar, Lucknow, Uttar Pradesh 226010, India.
Ajai Kumar
AK
Singh
Department of Medicine, B.R.D. Medical College, Gorakhpur, India.
Lalit
L
Sharma
Department of Neurology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Vibhuti Khand, Gomti Nagar, Lucknow, Uttar Pradesh 226010, India.
Dinkar
D
Kulshreshtha
Department of Neurology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Vibhuti Khand, Gomti Nagar, Lucknow, Uttar Pradesh 226010, India. Electronic address: anupthacker@yahoo.co.in.
Anup Kumar
AK
Thacker
D000293:Adolescent; D000328:Adult; D004569:Electroencephalography; D005074:Evoked Potentials, Visual; D005128:Eye Diseases / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D014390:Tuberculosis, Meningeal / Q000000981:diagnostic imaging / Q000503:physiopathology*; D014786:Vision Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology*; D014792:Visual Acuity; D014795:Visual Pathways / Q000503:physiopathology*; D055815:Young Adult
Neuro-ophthalmology; Tuberculous meningitis; Vision loss; Visual evoked response; Visual pathways