The unexpected role of mTORC1 in intestinal stem cells during calorie restriction.
a Department of Biology , Glenn Labs for the Science of Aging, and Koch Institute, MIT , Cambridge, MA , USA.
Masaki
M
Igarashi
a Department of Biology , Glenn Labs for the Science of Aging, and Koch Institute, MIT , Cambridge, MA , USA.
Leonard
L
Guarente
D000818:Animals; D031204:Caloric Restriction; D007422:Intestines / Q000166:cytology*; D000076222:Mechanistic Target of Rapamycin Complex 1 / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D019879:Paneth Cells / Q000378:metabolism; D015398:Signal Transduction; D013234:Stem Cells / Q000378:metabolism*
D000076222:Mechanistic Target of Rapamycin Complex 1
S6K1; SIRT1; calorie restriction; intestinal stem cell; mTORC1