Ulcer healing potential of ethanolic extract of Caralluma attenuata on experimental diabetic rats.
BACKGROUND
Available data indicated that diabetes mellitus (DM) increases the vulnerability of the gastric ulcers and the need of the hour is to develop effective agents to treat ulcer with diabetes for better patient compliance and cost effectiveness. The ulcer-healing properties of ethanolic extract of Caralluma attenuata (CAEt) against both chemically- and physically induced gastric ulcers in experimental rats are recently studied.


OBJECTIVE
To assess the ulcer healing potential of Ethanolic Extract of Caralluma attenuata on Experimental Diabetic Rats.


METHODS
The current study aimed to evaluate ulcer healing properties of CAEt on the aspirin induced gastric ulcer in rats with streptozotocin induced DM. The hypothesis is based on the fact that DM results in compromising the mucosal defensive factors associated with delay in gastric ulcer healing, and if these changes can be corrected by using agents known for their antidiabetic and antiulcer properties. Experimental albino rats were divided into six groups. Except for Group I, other groups contained streptozotocin-induced diabetic rats. Group I (normal control) and Group II (diabetic control) were administered vehicle, Groups III and IV (diabetic experimental) were administered CAEt in dose of 100 mg/kg and 250 mg/kg, respectively, and Groups V and VI (positive controls) were respectively administered oral standard drugs omeprazole, 20 mg/kg, and tolbutamide 10 mg/kg.


RESULTS
The results confirmed that the CAEt significantly decreases the ulcer index (P < 0.05) in the aspirin-induced gastric ulcers and also significantly exhibit antioxidant and glucose lowering activity in the diabetic ulcer rats. The study showed that C. attenuata has the potential to be used as an antiulcer agent in experimental diabetic rats.
Department of Pharmacy, Mewar University, Chittorgarh, Rajasthan, India.
Sunil
S
Garg
Amity Institute of Pharmacy, Amity University, Lucknow Campus, Lucknow, Uttar Pradesh, India.
Sajal
S
Srivastava
Department of Pharmacy, Dr. K. N. Modi Institute of Pharmaceutical Education, Modinagar, Uttar Pradesh, India.
Kisanpal
K
Singh
Clinical Research Division, Synapse Clinical Research Foundation, Delhi, India.
Alok
A
Sharma
R and D Division, INC Research Inc., Gurgaon, Haryana, India.
Kavita
K
Garg
Antiulcer agent; Caralluma attenuate; diabetes mellitus; herbal drug