Simultaneous determination of ascorbic acid, acetaminophen and codeine based on multi-walled carbon nanotubes modified with magnetic nanoparticles paste electrode.
Based on incorporating ZnCrFeO4 into multi-walled carbon nanotubes paste matrix (MWCNTs/ZnCrFeO4/CPE), a chemically modified electrode was prepared for the simultaneous determination of ascorbic acid (AA), acetaminophen (AC) and codeine (CO). The prepared electrode, MWCNTs/ZnCrFeO4/CPE, was characterized by scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS). The MWCNTs/ZnCrFeO4/CPE showed an efficient electrocatalytic activity for the oxidation of AA, AC, and CO. The separations of the oxidation peak potentials for AA-AC and AC-CO were about 250mV and 630mV, respectively. The calibration curves obtained for AA, AC, and CO were in the ranges of 0.4-730.0μmolL(-1), 0.1-368.0μmolL(-1), and 0.3-250.0μmolL(-1), respectively. The detection limits (S/N=3) were 0.03μmolL(-1), 0.009μmolL(-1), and 0.01μmolL(-1) for AA, AC, and CO, respectively. The method was also successfully employed as a selective, simple, and precise method to determinate AA, AC, and CO in pharmaceutical and biological samples.
Department of Chemistry, Payame Noor University, 19395-4697 Tehran, Islamic Republic of Iran. Electronic address: m.taei@ch.iut.ac.ir.
M
M
Taei
Department of Chemistry, Payame Noor University, 19395-4697 Tehran, Islamic Republic of Iran.
H
H
Salavati
Department of Chemistry, Payame Noor University, 19395-4697 Tehran, Islamic Republic of Iran.
F
F
Hasanpour
Department of Chemistry, Payame Noor University, 19395-4697 Tehran, Islamic Republic of Iran.
S
S
Habibollahi
Department of Chemistry, Payame Noor University, 19395-4697 Tehran, Islamic Republic of Iran.
H
H
Baghlani
D000082:Acetaminophen / Q000032:analysis* / Q000097:blood / Q000652:urine; D000596:Amino Acids / Q000737:chemistry; D001205:Ascorbic Acid / Q000032:analysis* / Q000097:blood / Q000652:urine; D015374:Biosensing Techniques; D003061:Codeine / Q000032:analysis* / Q000097:blood / Q000652:urine; D058266:Dielectric Spectroscopy; D055664:Electrochemical Techniques / Q000295:instrumentation*; D004566:Electrodes; D005290:Ferric Compounds / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010084:Oxidation-Reduction; D017550:Spectroscopy, Fourier Transform Infrared; D013607:Tablets / Q000737:chemistry
D000596:Amino Acids; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; D037742:Nanotubes, Carbon; D013607:Tablets; C585964:zinc chromium ferrite; D000082:Acetaminophen; D001205:Ascorbic Acid; D003061:Codeine
Acetaminophen; Ascorbic acid; Codeine; Multi-walled carbon nanotubes; ZnCrFeO(4)