Carbacaprazamycins: Chemically Stable Analogues of the Caprazamycin Nucleoside Antibiotics.
Carbacaprazamycins, which are chemically stable analogues of caprazamycins, were designed and synthesized. These analogues were active against drug-resistant bacterial pathogens such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci, and their activities were comparable to those of the parent caprazamycins. The effect of treatment with carbacaprazamycin on morphological changes in S. aureus indicated that the mode of action was completely different from those of existing peptidoglycan inhibitors.
Faculty of Pharmaceutical Sciences and ‡Center for Research and Education on Drug Discovery, Hokkaido University , Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
Satoshi
S
Ichikawa
Faculty of Pharmaceutical Sciences and ‡Center for Research and Education on Drug Discovery, Hokkaido University , Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
Mayumi
M
Yamaguchi
Faculty of Pharmaceutical Sciences and ‡Center for Research and Education on Drug Discovery, Hokkaido University , Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
Lee Shang
LS
Hsuan
Faculty of Pharmaceutical Sciences and ‡Center for Research and Education on Drug Discovery, Hokkaido University , Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
Yuta
Y
Kato
Faculty of Pharmaceutical Sciences and ‡Center for Research and Education on Drug Discovery, Hokkaido University , Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
Akira
A
Matsuda
MraY; antibiotics; caprazamycins; drug resistance; peptidoglycan