Salivary psoriasin (S100A7) correlates with diffusion capacity of carbon monoxide in a large cohort of systemic sclerosis patients.
Systemic sclerosis (SSc) is an autoimmune disease characterized by progressive fibrosis of the skin and the internal organs. In a previous work we suggested a correlation between levels of salivary psoriasin (S100A7) and pulmonary involvement in SSc patients. The goals of this study are to determine the distribution characteristics of psoriasin in whole saliva (WS) of SSc and healthy donor populations and define its predictive value on diffusion capacity of carbon monoxide (DLCO), along with others clinical parameters.



Salivary level of psoriasin was determined by ELISA kit in 134 SSc patients, 63 Raynaud syndrome patients, 40 patients affected by other connective diseases (non-case) and 74 healthy control subjects.



A significant increase of salivary psoriasin was observed in SSc patients when compared with other healthy and pathological controls. Moreover, we confirmed the efficacy of salivary psoriasin to correlate with DLCO in a large cohort of SSc patients.



Overall our results suggest a rapid, non invasive and low costing method which can help clinicians in the evaluation of SSc pulmonary involvement.
Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy. laura.giusti@unipi.it.
Laura
0000-0001-7366-1932
L
Giusti
Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, 56126, Pisa, Italy.
Francesca
F
Sernissi
Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.
Elena
E
Donadio
Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.
Federica
F
Ciregia
Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, 56126, Pisa, Italy.
Camillo
C
Giacomelli
Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.
Gino
G
Giannaccini
Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.
Maria Rosa
MR
Mazzoni
Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.
Antonio
A
Lucacchini
Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, 56126, Pisa, Italy.
Laura
L
Bazzichi
D002248:Carbon Monoxide / Q000378:metabolism*; D016022:Case-Control Studies; D015331:Cohort Studies; D004058:Diffusion; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D000075023:S100 Calcium Binding Protein A7; D009418:S100 Proteins / Q000378:metabolism*; D012463:Saliva / Q000378:metabolism*; D012595:Scleroderma, Systemic / Q000378:metabolism*
D000075023:S100 Calcium Binding Protein A7; D009418:S100 Proteins; C089242:S100A7 protein, human; D002248:Carbon Monoxide
Biomarker; Diffusion capacity of carbon monoxide (DLCO); Psoriasin; S100A7; Systemic sclerosis (SSc); Whole saliva