Common variants in FKBP5 gene and major depressive disorder (MDD) susceptibility: a comprehensive meta-analysis.
Previous studies have investigated the association between common variants in FKBP5 and MDD; however, the results remain inconsistent. In order to conduct a comprehensive meta-analysis of the association between FKBP5 variants and MDD risk, seven studies involving 26582 subjects, including 12491 cases with MDD and 14091 controls, were enrolled totally. Four common SNPs (rs1360780, rs4713916, rs3800373 and rs755658) with complete data from two or more studies were analyzed. In the total sample, there was no evidence of a significant association between MDD and any of the four SNPs using a random-effects model. However, after removing one heterogeneous German study, as indicated by sensitivity analysis, both the rs1360780 T-allele (Z = 2.95, P = 0.003, OR = 1.06, 95% CI = 1.02-1.11) and the rs3800373 C-allele (Z = 3.05, P = 0.002, OR = 1.07, 95% CI 1.02-1.12) were significantly associated with MDD in a fixed-effect model. Our study thus provides support for an association between specific FKBP5 genetic variants and MDD risk. Rs4713916 was not significantly associated with MDD; However, this analysis had limited statistical power and larger sample sizes are required to further validate this result. Future research should also investigate possible gender- and ethnicity-specific differences in the association between FKBP5 and MDD.
School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
Shuquan
S
Rao
Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Yao
Y
Yao
Disease Epigenetics Group, Murdoch Childrens Research Institute &Department of Paediatrics, University of Melbourne, 3052 Parkville, Victoria, Australia.|Inserm, U1061, Univ Montpellier, F-34093 Montpellier, France.
Joanne
J
Ryan
Mental Health Center, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, 610041, China.
Tao
T
Li
Department of Orthopedics, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, 610041, China.
Duan
D
Wang
Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Chuan
C
Zheng
Department of Psychiatry, First Clinical Medical College/First Hospital of Shanxi Medical University, Taiyuan, 030000, China.
Yong
Y
Xu
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences &Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 10005, China.
Qi
Q
Xu
D003865:Major Depressive Disorder / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D022021:Tacrolimus Binding Proteins / Q000235:genetics*; D000099159:Tacrolimus Binding Protein 5
D022021:Tacrolimus Binding Proteins; D000099159:Tacrolimus Binding Protein 5