[Allogeneic stem cell transplantation : An option for autoimmune diseases?]
According to experimental animal models and experiences of patients with coexisting autoimmune diseases, allogeneic stem cell transplantation has the potential to reestablish and maintain immunological tolerance. On the other hand, it is associated with significant treatment related mortality and may induce diverse immunological diseases by graft-versus-host reaction. Other than with severe aplastic anemia, it is not an established therapy for autoimmune diseases; it is under investigation in clinical trials and might be considered in severe, refractory immune cytopenia.
Abteilung für Onkologie, Hämatologie, klinische Immunologie, Rheumatologie, Pulmologie, Medizinische Klinik der Universität Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Deutschland. stefan.wirths@med.uni-tuebingen.de.
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Wirths
Abteilung für Onkologie, Hämatologie, klinische Immunologie, Rheumatologie, Pulmologie, Medizinische Klinik der Universität Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Deutschland.
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Bethge
Abteilung für Onkologie, Hämatologie, klinische Immunologie, Rheumatologie, Pulmologie, Medizinische Klinik der Universität Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Deutschland.
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Henes
D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000628:therapy*; D019317:Evidence-Based Medicine; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D012219:Rheumatology / Q000639:trends; D033581:Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods*; D014184:Transplantation, Homologous / Q000009:adverse effects / Q000379:methods; D016896:Treatment Outcome
Allogeneic stem cell transplantation; Chimerism; Graft-versus-host disease; Immune tolerance; Treatment-related mortality