Sigmoid Sinus Characteristics Correlate with Early Clinical and Imaging Surrogates in Anterior Circulation Ischemic Stroke.
Cerebral venous outflow may play a decisive role in acute ischemic stroke. Here, we assessed the relation of cerebral sinus vein characteristics with clinical and imaging surrogates of early outcome in acute ischemic stroke. We evaluated cerebral vein characteristics in 212 patients with the middle cerebral artery (MCA) occlusive stroke confirmed by CT angiography CTA within 6 h from symptom onset. Readout parameters included volume and density of the sigmoid sinus (SS) and density of the superior sagittal sinus (SupSagS). These were correlated with early clinical outcome defined as hospital death (HD), final infarct volume (FIV), and National Institute of Health Stroke Scale (NIHSS) at discharge. We found a correlation for the volume of the right SS and the FIV when the M1 segment of the MCA of either side was occluded (p = 0.002, Rho = 0.206, n = 134). A decrease in SS density was more pronounced in the subgroup with unfavorable outcome (NIHSS > 15 + HD) but only when the left hemisphere was affected (p = 0.026, n = 101). On stepwise logistic regression analysis, adjusted for on-admission NIHSS, age at presentation, and FIV, smaller SS volume was independently associated with lower odds for hospital death (n = 183, OR 0.13, 95 % CI 0.02-0.94, p = 0.043). A larger right SS and a decrease in density increase the risk of unfavorable early clinical and imaging outcome in AIS. This finding of an outflow pattern independent of the stroke site implicates an involvement of the cerebral venous drainage system in the pathophysiology of ischemic stroke.
Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, Salzburg, Austria.
Slaven
S
Pikija
Department of Neurology, Univerzitetni Klinični Center Maribor, Maribor, Slovenia.
Jozef
J
Magdic
Neurovascular Imaging Research Core and UCLA Stroke Center, University of California, Los Angeles, CA, USA.
David S
DS
Liebeskind
Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, Salzburg, Austria.
Arthur
A
Karamyan
Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, Salzburg, Austria.
Nele
N
Bubel
Division of Neuroradiology, Christian Doppler Medical Center, Paracelsus Medical University Salzburg, Salzburg, Austria.
Mark R
MR
McCoy
Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, Salzburg, Austria. j.sellner@salk.at.|Department of Neurology, Klinikum rechts der Isar, Technische Universität München, München, Germany. j.sellner@salk.at.
Johann
J
Sellner
D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D005260:Female; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D015912:Thrombolytic Therapy / Q000379:methods; D016896:Treatment Outcome
Biomarker; Cerebral veins; Computed tomography; Densitometry; Ischemic stroke; Outcome