Lignans and indole alkaloids from the seeds of Centaurea vlachorum Hartvig (Asteraceae), growing wild in Albania and their biological activity.
The present phytochemical investigation of the seeds of Centaurea vlachorum led to the isolation and characterisation of four compounds including two indole alkaloids N-(p-coumaroyl) serotonin (1) and moschamine (2) and two dibenzylbutyrolactone lignans matairesinol (3) and arctiin (4). This is the first report on the isolation of non-volatile secondary metabolites from C. vlachorum. The chemataxonomic significance of these compounds was summarised. Moreover, the isolated compounds were tested for their free radical scavenging activity using the following in vitro assays: (i) interaction with the free stable radical of DPPH (1,1-diphenyl-2-picrylhydrazyl), (ii) inhibition of linoleic acid peroxidation with the dihydrochloric acid of 2,2-Azobis-2-amidinopropane (AAPH). Finally, their inhibitory activity towards soybean lipoxygenase was evaluated, using linoleic acid as substrate.
a Laboratory of Pharmacognosy, Faculty of Health Sciences, School of Pharmacy , Aristotle University of Thessaloniki , Thessaloniki , Greece.|b Faculty of Natural Sciences, Department of Industrial Chemistry , University of Tirana , Tirana , Albania.
Entela
E
Hodaj
a Laboratory of Pharmacognosy, Faculty of Health Sciences, School of Pharmacy , Aristotle University of Thessaloniki , Thessaloniki , Greece.
Olga
O
Tsiftsoglou
c Department of Pharmacy , Aldent University , Tirana , Albania.
Sokol
S
Abazi
d Department of Pharmaceutical Chemistry, School of Pharmacy, Faculty of Health Sciences , Aristotle University of Thessaloniki , Thessaloniki , Greece.
Dimitra
D
Hadjipavlou-Litina
a Laboratory of Pharmacognosy, Faculty of Health Sciences, School of Pharmacy , Aristotle University of Thessaloniki , Thessaloniki , Greece.
Diamanto
D
Lazari
D000975:Antioxidants / Q000494:pharmacology; D031179:Centaurea / Q000737:chemistry* / Q000254:growth & development; D026121:Indole Alkaloids / Q000032:analysis / Q000494:pharmacology*; D017705:Lignans / Q000032:analysis / Q000494:pharmacology*; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology; D012639:Seeds / Q000737:chemistry
D000975:Antioxidants; D026121:Indole Alkaloids; D017705:Lignans; D016859:Lipoxygenase Inhibitors
Asteraceae; Centaurea vlachorum; indole alkaloids; lignans