Whole-body MRI, FDG-PET/CT, and bone marrow biopsy, for the assessment of bone marrow involvement in patients with newly diagnosed lymphoma.
To compare whole-body MRI (WB-MRI) with diffusion-weighted imaging (DWI), FDG-PET/CT, and bone marrow biopsy (BMB), for the evaluation of bone marrow involvement (BMI) in patients with newly diagnosed lymphoma.



This retrospective study was approved by our Institutional Review Board. Two independent radiologists and one nuclear medicine specialist reviewed all WB-MRI and FDG-PET/CT scans prospectively performed on 104 patients with newly diagnosed lymphoma (53 males; 47 Hodgkin; mean age: 44 years; range, 15-86 years) between 2013 and 2015. The delay between imaging scans and BMBs was up to 10 days. The diagnostic accuracy of WB-MRI (1.5 Tesla MR scanner, with T1w, T2w-STIR, and DWI sequences) was evaluated using BMB and FDG-PET/CT as the reference standard. We applied Cohen's kappa coefficient to assess the inter-observer agreement in WB-MRI interpretation and to compare WB-MRI, FDG-PET/CT and BMB. The Student's t test was done to compare pelvic marrow ADC values of patients with positive and negative BMB. A P-value of < 0.01 was considered significant.



Inter-observer agreement was excellent (k = 0.937). Agreement between WB-MRI and FDG-PET/CT was excellent, with a k = 0.935. Agreement between WB-MRI and BMB was moderate (k = 0.489), and fair between FDG-PET/CT and BMB (k = 0.370). WB-MRI and FDG-PET/CT were falsely negative in four indolent non-Hodgkin lymphomas with BMI < 30% of marrow cellularity. Conversely, WB-MRI and FDG-PET/CT detected all cases with a BMI>30% of marrow cellularity. Mean ADC values in patients with positive and negative BMB were not significantly different (P = 0.049).



WB-MRI and FDG-PET/CT are valuable tools for the assessment of BMI.



3 J. Magn. Reson. Imaging 2017;45:1082-1089.
Department of Radiology, DIBIMED, University of Palermo, Palermo, Italy.
Domenico
0000-0001-7989-9861
D
Albano
Department of Hematology I, Azienda Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy.
Caterina
C
Patti
Department of Radiology, DIBIMED, University of Palermo, Palermo, Italy.
Roberto
R
Lagalla
Department of Radiology, DIBIMED, University of Palermo, Palermo, Italy.
Massimo
M
Midiri
Department of Radiology, DIBIMED, University of Palermo, Palermo, Italy.
Massimo
M
Galia
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D001853:Bone Marrow / Q000000981:diagnostic imaging / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008223:Lymphoma / Q000000981:diagnostic imaging* / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012189:Retrospective Studies; D051598:Whole Body Imaging / Q000379:methods*; D055815:Young Adult
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
bone marrow biopsy; lymphoma; magnetic resonance imaging; positron emission tomography-computerized tomography; staging