title: [A Case of HER2-Positive Inflammatory Breast Cancer for Which Preoperative Chemotherapy with Pertuzumab Resulted in a Pathological Complete Response].
abstract: A 52-year-old woman presented with redness and swelling with a peau d'orange appearance in the whole right breast. Ultrasound revealed elevated subcutaneus fat density and a diffuse hypoechoic area. She was diagnosed with inflammatory breast cancer(T4dN2M0, Stage III B of the HER2 subtype). After 4 courses of EC treatment as primary systemic therapy, the hypoechoic area was still present. Subsequent chemotherapy with pertuzumab, trastuzumab, and docetaxel was effective, as hypoechoic area was not observed on ultrasound. She underwent mastectomy and axillary dissection, and pathological examination revealed pCR. At present, 2 years after surgery, the patient is alive with no reccurence.
authors.affiliation: Dept. of Surgery, Kuwana City Medical Center.
authors.forename: Naomi
authors.initials: N
authors.lastname: Konishi
authors.forename: Takao
authors.initials: T
authors.lastname: Iwanaga
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Ishino
authors.forename: Aya
authors.initials: A
authors.lastname: Sugisawa
authors.forename: Shozo
authors.initials: S
authors.lastname: Ide
authors.forename: Hiroko
authors.initials: H
authors.lastname: Kimura
authors.forename: Takashi
authors.initials: T
authors.lastname: Iwata
authors.forename: Hideki
authors.initials: H
authors.lastname: Watanabe
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yokoe
authors.forename: Eiki
authors.initials: E
authors.lastname: Ojima
authors.forename: Hideki
authors.initials: H
authors.lastname: Ito
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ikeda
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Tonouchi
authors.forename: Chika
authors.initials: C
authors.lastname: Shigemori
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D001706:Biopsy; D005260:Female; D006801:Humans; D058922:Inflammatory Breast Neoplasms / Q000737:chemistry / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D008408:Mastectomy; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human; C485206:pertuzumab