title: Current state of knowledge of hepatic encephalopathy (part III): non-absorbable disaccharides.
abstract: Nonabsorbable disaccharides have been the mainstay of treatment for hepatic encephalopathy since introduced into clinical practice in 1966. Their beneficial effects reflect their ability to reduce the intestinal production/absorption of ammonia. A recent Cochrane review confirmed the efficacy and safety of nonabsorbable disaccharides for the treatment and prevention of hepatic encephalopathy in patients with cirrhosis. The findings were robust and support the use of nonabsorbable disaccharides as a first line treatment for hepatic encephalopathy, in this patient population, and for its prevention.
authors.affiliation: UCL Institute for Liver & Digestive Health, Division of Medicine, Royal Free Campus, University College London, London, NW3 2PF, UK. marsha.morgan@ucl.ac.uk.
authors.forename: Marsha Y
authors.initials: MY
authors.lastname: Morgan
mesh_terms: D000641:Ammonia / Q000037:antagonists & inhibitors / Q000378:metabolism; D000818:Animals; D004187:Disaccharides / Q000494:pharmacology / Q000627:therapeutic use*; D005765:Gastrointestinal Agents / Q000494:pharmacology / Q000627:therapeutic use; D007722:Health Knowledge, Attitudes, Practice; D006501:Hepatic Encephalopathy / Q000188:drug therapy* / Q000378:metabolism*; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects / Q000502:physiology*; D007792:Lactulose / Q000494:pharmacology / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic / Q000379:methods; D013402:Sugar Alcohols / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D004187:Disaccharides; D005765:Gastrointestinal Agents; D013402:Sugar Alcohols; D007792:Lactulose; D000641:Ammonia
keywords: Hepatic encephalopathy; efficacy; lactitol; lactulose; safety