title: Colorectal Cancer Mortality in Shiraz, Iran.
abstract: BACKGROUND
  Mortality among Iranian patients with colorectal cancer has not been fully examined and the factors associated with their survival are still controversial. This study aimed to determine the mortality rate and its related factors among the patients with colorectal cancer in southwestern regions in Iran.
  
  
  METHODS
  This prospective cohort study was conducted on 220 patients with colorectal cancer referred to Fahighi Hospital, Shiraz, Iran from 2009 to 2014. Data were collected from the patients' medical records and were analyzed using Cox regression analysis.
  
  
  RESULTS
  Over a median follow-up of 29.3 months, 56 out of the 220 patients (25.5%) died, 32 (14.5%) aged below 40 years, and 45.5% were female. Based on the results of multiple Cox regression analysis, family history of gastrointestinal cancer, stage III, former smoking, type of lesion (fungative and polypoid), and opium use were associated with a greater risk of colorectal cancer mortality (all <0.05).
  
  
  CONCLUSIONS
  This cohort study found that the mortality rate of colorectal cancer in Iran is lower than that in European countries. In addition, behavioral and clinical factors were significantly associated with the survival rate. Addressing the related factors would help healthcare providers and physicians provide the best care and improve the survival rate.
authors.affiliation: Student Research Committee, Department of Epidemiology, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran E-mail : ghaemh@sums.ac.ir.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Dianatinasab
authors.forename: Haleh
authors.initials: H
authors.lastname: Ghaem
authors.forename: Abbas
authors.initials: A
authors.lastname: Rezaianzadeh
authors.forename: Seysd Vahid
authors.initials: SV
authors.lastname: Hosseini
authors.forename: Hajar
authors.initials: H
authors.lastname: Khazraei
mesh_terms: D000328:Adult; D015179:Colorectal Neoplasms / Q000401:mortality*; D005060:Europe; D005260:Female; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012042:Registries; D012044:Regression Analysis; D012307:Risk Factors; D015996:Survival Rate