title: Caulobacter spp: A Rare Pathogen Responsible for Paucisintomatic Persisitant Meningitis in a Glioblastoma Patient.
abstract: BACKGROUND
  Caulobacter spp. are Gram-negative bacteria that have rarely been found to be pathogenic in humans.
  
  
  METHODS
  This report describes the first case, to our knowledge, of meningitis in an adult patient caused by Caulobacter spp. A 75-year-old man was operated for a glioblastoma with no evident signs of primary infection in the wound site. Eight days after surgery, the patient developed signs and symptoms of meningitis. Caulobacter was then isolated on 3 separate occasions in the patient's cerebrospinal fluid. Thereafter, specific antibiotic therapy began. After 2 weeks of therapy, the patient was discharged with complete resolution of any related symptoms.
  
  
  CONCLUSIONS
  Caulobacter spp. can cause adult meningitis even where there is no evidence of surgical site infection.
authors.affiliation: Division of Neurosurgery, Department of Neuroscience, University of Torino, Turin, Italy. Electronic address: federica.penner@gmail.com.
authors.forename: Federica
authors.initials: F
authors.lastname: Penner
authors.affiliation: Microbiology and Virology Laboratory, University of Turin, Turin, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Brossa
authors.affiliation: Microbiology and Virology Laboratory, University of Turin, Turin, Italy.
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Barbui
authors.affiliation: Division of Neurosurgery, Department of Neuroscience, University of Torino, Turin, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Ducati
authors.affiliation: Microbiology and Virology Laboratory, University of Turin, Turin, Italy.
authors.forename: Rossana
authors.initials: R
authors.lastname: Cavallo
authors.affiliation: Division of Neurosurgery, Department of Neuroscience, University of Torino, Turin, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Zenga
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000601:surgery*; D016934:Caulobacter / Q000187:drug effects / Q000472:pathogenicity*; D002555:Cerebrospinal Fluid / Q000382:microbiology; D005909:Glioblastoma / Q000601:surgery*; D016905:Gram-Negative Bacterial Infections / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008297:Male; D016920:Meningitis, Bacterial / Q000175:diagnosis* / Q000188:drug therapy; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D011183:Postoperative Complications / Q000175:diagnosis* / Q000188:drug therapy; D013845:Thienamycins / Q000627:therapeutic use; D014774:Virulence
chemical_list: D013845:Thienamycins; D000077731:Meropenem
keywords: Caulobacter; Complications; Glioblastoma; Meningitis; Neurosurgery; Postoperative meningitis