title: HMGB1: The metabolic weapon in the arsenal of NK cells.
abstract: Targeting tumor glycolysis would hit the main energy source of cancer. We show that natural killer (NK) cells pursue this strategy by employing high mobility group box 1 (HMGB1) protein-a well-known proinflammatory cytokine-to specifically target glycolysis in cancer cells. This opens up new perspectives for cancer immunotherapy.
authors.affiliation: German Cancer Research Center, Research Group Innate Immunity , Heidelberg, Germany.
authors.forename: Adelheid
authors.initials: A
authors.lastname: Cerwenka
authors.affiliation: Institute of Pathology, University of Heidelberg , Heidelberg, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Kopitz
authors.affiliation: Institute of Pathology, University of Heidelberg , Heidelberg, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Schirmacher
authors.affiliation: Institute of Pathology, University Medical Center Mainz , Mainz, Germany.
authors.forename: Wilfried
authors.initials: W
authors.lastname: Roth
authors.affiliation: Institute of Pathology, University of Heidelberg, Heidelberg, Germany; German Cancer Research Center, Clinical Cooperation Unit Molecular Tumor Pathology, Heidelberg, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Gdynia
keywords: Cancer; HMGB1; NK cells; Natural Killer Cells; cell death; immunotherapy; innate immunity; metabolism