title: Lack of Any Role of Systemic Inflammatory Responses in Predicting Muscle Invasion by Bladder Cancer.
abstract: BACKGROUND
  The purpose of this study is to evaluate if there is a relation between platelet:lymphocyte ratio (PLR) and neutrophil lymphocyte ratio (NLR) values and tumour histology and spread in bladder cancer cases.
  
  
  METHODS
  Bladder cancer patients undergoing TUR-M operation, with histopathologically verified diagnosis, followed-up and treated at the Private Medical Park Gaziantep Hospital between 2010 and 2015, were included in the study. NLR and PLR values were calculated using complete blood count data obtained at the first presentation.
  
  
  RESULTS
  A total of 99 patients were included in the study, 7 (7.1%) women and 92 men (92.9%). When NLR was used as the indicator of systemic inflammatory response (SIR), it was determined that 52 (52.5%) of the patients were SIR negative and 47 (47.5%) SIR positive. No significant relation could be detected between NLR and tumour grade and muscle invasion (p=0.948, p=0.480). When PLR was used as SIR indicator, it was determined that 71 (71.7%) of the patients were found as negative and 28 (28.3%) as positive. No significant relation could be detected between PLR and tumour grade and muscle invasion (p=0.651, p=0.494).
  
  
  CONCLUSIONS
  In our study we did not detected a relation between tumour histological behavior and PLR and NLR in bladder cancer. However, NLR and PLR are easily calculated, accessible, inexpensive and simple-to-use laboratory data from whole blood counts.
authors.affiliation: Medicalpark Gaziantep Hospital, Department of Urology, Gaziantep, Turkey E-mail : mustafayildirim7@yahoo.com.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Solakhan
authors.forename: Ozlem
authors.initials: O
authors.lastname: Demirpence
authors.forename: Nuri
authors.initials: N
authors.lastname: Orhan
authors.forename: Omer Aydin
authors.initials: OA
authors.lastname: Yildirim
authors.forename: Ebru
authors.initials: E
authors.lastname: Guzel
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yildirim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001772:Blood Cell Count / Q000379:methods; D001792:Blood Platelets / Q000473:pathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D007958:Leukocyte Count / Q000379:methods; D018655:Lymphocyte Count / Q000379:methods; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000473:pathology*; D009504:Neutrophils / Q000473:pathology; D010976:Platelet Count / Q000379:methods; D011379:Prognosis; D012189:Retrospective Studies; D001749:Urinary Bladder Neoplasms / Q000473:pathology*