title: Natural Compounds for Overcoming Multidrug Resistance in Mycobacteria.
abstract: BACKGROUND
  Tuberculosis caused by Mycobacterium tuberculosis (MTB) is currently a major health concern due to its growing mortality rates around the world. The known anti-TB drugs although are available for the treatment but it produces adverse side effects on the human health and are also not very cost effective. Moreover, emergence of multidrug resistance (MDR) phenomenon has also compromised their activities.
  
  
  OBJECTIVE
  Hence there is an urgent need to search novel drugs and compounds from natural sources having lesser side effects which have proved to be vital and widely used nowadays. Many recent studies have been established which show promising antimycobacterial activities against MTB.
  
  
  RESULTS
  This review summarizes the various naturally occurring active compounds acting on different targets against MTB. Moreover, it also deals with the compounds having patent perspective.
  
  
  CONCLUSIONS
  Together, the article laid emphasis on reverting towards the natural compounds so that further work is carried out to exploit their therapeutic interventions.
authors.forename: Sharda
authors.initials: S
authors.lastname: Sharma
authors.forename: Saif
authors.initials: S
authors.lastname: Hameed
authors.affiliation: Amity Institute of Biotechnology, Amity University Haryana, Gurgaon (Manesar)- 122413, India. drzeeshanfatima@gmail.com.
authors.forename: Zeeshan
authors.initials: Z
authors.lastname: Fatima
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D001688:Biological Products / Q000494:pharmacology*; D018432:Drug Resistance, Multiple / Q000187:drug effects*; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D010330:Patents as Topic; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D001688:Biological Products