title: [Giant coronary aneurysms in infants with Kawasaki disease].
abstract: BACKGROUND
  Kawasaki disease (KD) is an acute vasculitis of unknown origin and predominant in males. The long-term effects of the disease depend on whether there are coronary lesions, particularly aneurysms. The prognosis of patients with giant aneurysms is very poor due to their natural progression to coronary thrombosis or severe obstructive lesions.
  
  
  OBJECTIVE
  A series of 8 cases is presented where the epidemiology and diagnostic methods are described. The treatment of the acute and long-term cardiovascular sequelae is also reviewed.
  
  
  METHODS
  A descriptive analysis was conducted on patients admitted to the Paediatric Cardiology Unit of La Fe University Hospital (Valencia) with KD and a coronary lesion.
  
  
  RESULTS
  More than one artery was involved in all patients. Although early diagnosis was established in only two cases, none of the patients had severe impairment of ventricular function during the acute phase. Treatment included intravenous gammaglobulin and acetylsalicylic acid at anti-inflammatory doses during the acute phase. A combination of dual antiplatelet therapy and corticosteroids was given in cases of coronary thrombosis. The silent aneurysms continue to persist.
  
  
  CONCLUSIONS
  KD is the most common cause of acquired heart disease in children. The delay in diagnosis is associated with a greater likelihood of coronary lesions that could increase the risk of cardiovascular events in adulthood. Thus, this subgroup requires close clinical monitoring for a better control of cardiovascular risk factors over time.
authors.affiliation: Servicio de Cardiología Pediátrica, Hospital Universitario y Politécnico La Fe, Valencia, España. Electronic address: tonisanchan@hotmail.com.
authors.forename: Antonio
authors.initials: A
authors.lastname: Sánchez Andrés
authors.affiliation: Servicio de Cardiología Pediátrica, Hospital Universitario y Politécnico La Fe, Valencia, España.
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Salvador Mercader
authors.affiliation: Servicio de Cardiología Pediátrica, Hospital Universitario y Politécnico La Fe, Valencia, España.
authors.forename: Julia
authors.initials: J
authors.lastname: Seller Moya
authors.affiliation: Servicio de Cardiología Pediátrica, Hospital Universitario y Politécnico La Fe, Valencia, España.
authors.forename: José Ignacio
authors.initials: JI
authors.lastname: Carrasco Moreno
mesh_terms: D002675:Child, Preschool; D003323:Coronary Aneurysm / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications*; D012189:Retrospective Studies
keywords: Aneurismas coronarios gigantes; Children; Enfermedad de Kawasaki; Giant coronary aneurysms; Infancia; Kawasaki disease