title: Post Stroke Dysglycemia and Acute Infarct Volume Growth: A Study Using Continuous Glucose Monitoring.
abstract: The aim of the present study was to clarify the effect of glucose profiles after stroke, which was assessed by a continuous glucose monitoring (CGM) device.
  
  
  
  Acute ischemic stroke patients within 24 h of onset were prospectively studied. CGM was performed for 72 h after admission. CGM parameters were evaluated as follows: (1) mean glucose level, (2) area under the curve (AUC) for glucose level >140 mg/dl and (3) SD of the glucose level. Infarct volume was measured at admission and 24 and 72 h after admission using diffusion-weighted imaging. CGM data and infarct volume growth were compared at 24 and 72 h.
  
  
  
  Seventy-eight patients were enrolled in the present study. Spearman's rank correlation coefficients showed that both the mean glucose level (r = 0.433, p < 0.001 for 24 h; r = 0.308, p = 0.006 for 72 h) and AUC >140 mg/dl (r = 0.417, p < 0.001 for 24 h; r = 0.277, p = 0.014 for 72 h) were significantly correlated with acute infarct volume growth. The SD of the glucose level was associated with infarct volume growth at 24 h (r = 0.303, p = 0.007), but not 72 h (r = 0.195, p = 0.088).
  
  
  
  Post-stroke hyperglycemia was associated with infarct volume growth during the acute phase of ischemic stroke.
authors.affiliation: Department of Stroke Medicine, Kawasaki Medical School, Kurashiki, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Shimoyama
authors.forename: Kazumi
authors.initials: K
authors.lastname: Kimura
authors.forename: Junichi
authors.initials: J
authors.lastname: Uemura
authors.forename: Naoki
authors.initials: N
authors.lastname: Saji
authors.forename: Kensaku
authors.initials: K
authors.lastname: Shibazaki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D001786:Blood Glucose / Q000378:metabolism*; D002341:Carotid Artery Thrombosis / Q000097:blood* / Q000150:complications*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000097:blood* / Q000209:etiology*; D020244:Infarction, Middle Cerebral Artery / Q000097:blood* / Q000150:complications*; D018810:Magnetic Resonance Angiography; D008297:Male; D008991:Monitoring, Physiologic / Q000295:instrumentation*; D011446:Prospective Studies; D020521:Stroke / Q000097:blood* / Q000150:complications*
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human