title: Bringing Prebiotic Nucleosides and Nucleotides Down to Earth.
abstract: There may be more than one way leading to RNA: Recent discoveries in the synthesis of nucleoside and nucleotide precursors are described and put into the wider context of prebiotic systems chemistry. Mixing Butlerow's carbohydrate precursors with Traube's 5-formylaminopyrimidines has led to the formation of prebiotic purine nucleosides whereas the mixing of 5-phosphoribose with barbituric acid and melamine gave supramolecular fibers from stacks of Whitesides' rosettas.
authors.affiliation: Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, Université de Lyon, Claude Bernard Lyon 1, 43 bdv du 11 novembre 1918, 69622, Villeurbanne Cedex, France.
authors.forename: Michele
authors.initials: M
authors.lastname: Fiore
authors.affiliation: Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, Université de Lyon, Claude Bernard Lyon 1, 43 bdv du 11 novembre 1918, 69622, Villeurbanne Cedex, France. strazewski@univ-lyon1.fr.
authors.forename: Peter
authors.initials: P
authors.lastname: Strazewski
mesh_terms: D009690:Nucleic Acid Conformation; D009705:Nucleosides / Q000737:chemistry*; D009711:Nucleotides / Q000737:chemistry*; D056692:Prebiotics
chemical_list: D009705:Nucleosides; D009711:Nucleotides; D056692:Prebiotics
keywords: barbituric acid; formamides; formamidopyrimidines; melamine; prebiotic systems chemistry