title: Pathogen metadata platform: software for accessing and analyzing pathogen strain information.
abstract: BACKGROUND
  Pathogen metadata includes information about where and when a pathogen was collected and the type of environment it came from. Along with genomic nucleotide sequence data, this metadata is growing rapidly and becoming a valuable resource not only for research but for biosurveillance and public health. However, current freely available tools for analyzing this data are geared towards bioinformaticians and/or do not provide summaries and visualizations needed to readily interpret results.
  
  
  RESULTS
  We designed a platform to easily access and summarize data about pathogen samples. The software includes a PostgreSQL database that captures metadata useful for disease outbreak investigations, and scripts for downloading and parsing data from NCBI BioSample and BioProject into the database. The software provides a user interface to query metadata and obtain standardized results in an exportable, tab-delimited format. To visually summarize results, the user interface provides a 2D histogram for user-selected metadata types and mapping of geolocated entries. The software is built on the LabKey data platform, an open-source data management platform, which enables developers to add functionalities. We demonstrate the use of the software in querying for a pathogen serovar and for genome sequence identifiers.
  
  
  CONCLUSIONS
  This software enables users to create a local database for pathogen metadata, populate it with data from NCBI, easily query the data, and obtain visual summaries. Some of the components, such as the database, are modular and can be incorporated into other data platforms. The source code is freely available for download at https://github.com/wchangmitre/bioattribution .
authors.affiliation: Data Analytics Department, The MITRE Corporation, 2280 Historic Decatur Rd, San Diego, CA, 92106, USA.
authors.forename: Wenling E
authors.initials: WE
authors.lastname: Chang
authors.affiliation: Data Analytics Department, The MITRE Corporation, 202 Burlington Rd, Bedford, MA, 01730, USA.
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Peterson
authors.affiliation: Data Analytics Department, The MITRE Corporation, 202 Burlington Rd, Bedford, MA, 01730, USA.
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Garay
authors.affiliation: Data Analytics Department, The MITRE Corporation, 202 Burlington Rd, Bedford, MA, 01730, USA. tkorves@mitre.org.
authors.forename: Tonia
authors.initials: T
authors.lastname: Korves
mesh_terms: D016208:Databases, Factual; D004196:Disease Outbreaks; D064349:Genome, Microbial; D023281:Genomics; D006801:Humans; D000071253:Metadata; D012984:Software
keywords: BioSample; Biosurveillance; Geocoding; Java; LabKey; Metadata; Pathogen; PostgreSQL