title: The effects of dietary and herbal phytochemicals on drug transporters.
abstract: Membrane transporter proteins (the ABC transporters and SLC transporters) play pivotal roles in drug absorption and disposition, and thus determine their efficacy and safety. Accumulating evidence suggests that the expression and activity of these transporters may be modulated by various phytochemicals (PCs) found in diets rich in plants and herbs. PC absorption and disposition are also subject to the function of membrane transporter and drug metabolizing enzymes. PC-drug interactions may involve multiple major drug transporters (and metabolizing enzymes) in the body, leading to alterations in the pharmacokinetics of substrate drugs, and thus their efficacy and toxicity. This review summarizes the reported in vitro and in vivo interactions between common dietary PCs and the major drug transporters. The oral absorption, distribution into pharmacological sanctuaries and excretion of substrate drugs and PCs are considered, along with their possible interactions with the ABC and SLC transporters which influence these processes.
authors.affiliation: School of Science, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand; School of Interdisciplinary Health Studies, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Pharmacology & Clinical Pharmacology, School of Medical Sciences, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.
authors.forename: Jezrael
authors.initials: J
authors.lastname: Revalde
authors.affiliation: Department of Pharmacology & Clinical Pharmacology, School of Medical Sciences, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand. Electronic address: j.paxton@auckland.ac.nz.
authors.forename: James W
authors.initials: JW
authors.lastname: Paxton
mesh_terms: D018528:ATP-Binding Cassette Transporters; D000818:Animals; D004032:Diet; D004347:Drug Interactions; D006801:Humans; D026901:Membrane Transport Proteins; D064209:Phytochemicals / Q000494:pharmacology*
chemical_list: D018528:ATP-Binding Cassette Transporters; D026901:Membrane Transport Proteins; D064209:Phytochemicals
keywords: (−)-Epigallocatechin gallate (PubChem CID: 65064); ABC transporter; Chrysin (PubChem CID: 5281607); Curcumin (PubChem CID: 969516); Digoxin (PubChem CID: 2724385); Food–drug interactions; Metformin (PubChem CID: 4091); Morin (PubChem CID: 5281670); Pharmacokinetics; Phytochemical; Quercetin (PubChem CID: 5280343); Quinine (PubChem CID: 3034034); SLC transporter; SN-38 (PubChem CID: 104842); Talinolol (PubChem CID: 68770)