title: Plasma Leptin Is Elevated in Acute Exacerbation of Idiopathic Pulmonary Fibrosis.
abstract: Background. The natural history of idiopathic pulmonary fibrosis (IPF) is very complex and unpredictable. Some patients will experience acute exacerbation (AE) and fatal outcomes. Methods. The study included 30 AE-IPF patients, 32 stable IPF (S-IPF) patients, and 12 healthy controls. We measured the plasma concentrations of leptin and KL-6. Simple correlation was used to assess associations between leptin and other variables. Plasma leptin levels were compared between AE-IPF and S-IPF subjects, decedents, and survivors. Kaplan-Meier curves were used to display survival and Cox proportional hazards regression was used to examine risk factors for survival. Results. In subjects with AE-IPF, plasma leptin was significantly greater than in subjects with S-IPF (p = 0.0003) or healthy controls (p < 0.0001). Plasma leptin was correlated with BMI, KL-6, LDH, CRP, and PaO2/FiO2 (p = 0.007; p = 0.005; p = 0.003; p = 0.033; and p = 0.032, resp.). Plasma leptin was significantly greater in 33 decedents than in the 23 survivors (p = 0.007). Multivariate Cox regression analysis showed leptin (>13.79 ng/mL) was an independent predictor of survival (p = 0.004). Conclusions. Leptin could be a promising plasma biomarker of AE-IPF occurrence and predictor of survival in IPF patients.
authors.affiliation: Department of Respiratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Nanjing University Medical School, Nanjing, Jiangsu 210008, China.
authors.forename: Mengshu
authors.identifier: 0000-0002-8735-1262
authors.initials: M
authors.lastname: Cao
authors.affiliation: Interstitial Lung Disease Program, Department of Medicine, National Jewish Health, University of Colorado Denver, Denver, CO 80206, USA.
authors.forename: Jeffery J
authors.identifier: 0000-0002-9874-8265
authors.initials: JJ
authors.lastname: Swigris
authors.affiliation: Department of Respiratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Nanjing University Medical School, Nanjing, Jiangsu 210008, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Respiratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Nanjing University Medical School, Nanjing, Jiangsu 210008, China.
authors.forename: Min
authors.initials: M
authors.lastname: Cao
authors.affiliation: Department of Respiratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Nanjing University Medical School, Nanjing, Jiangsu 210008, China.
authors.forename: Yuying
authors.initials: Y
authors.lastname: Qiu
authors.affiliation: Department of Respiratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Nanjing University Medical School, Nanjing, Jiangsu 210008, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Huang
authors.affiliation: Department of Respiratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Nanjing University Medical School, Nanjing, Jiangsu 210008, China.
authors.forename: Yonglong
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: Department of Respiratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Nanjing University Medical School, Nanjing, Jiangsu 210008, China.
authors.forename: Hourong
authors.identifier: 0000-0001-7618-6436
authors.initials: H
authors.lastname: Cai
mesh_terms: D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000097:blood* / Q000401:mortality / Q000473:pathology*; D053208:Kaplan-Meier Estimate; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000097:blood; D016016:Proportional Hazards Models
chemical_list: D015415:Biomarkers; D020738:Leptin; C060192:MUC1 protein, human; D018396:Mucin-1; D002097:C-Reactive Protein