title: Emergence of Acinetobacter baumannii ST730 carrying the blaOXA-72 gene in Brazil.
abstract: Over the last decade, Acinetobacter baumannii resistant to carbapenems has emerged in many medical centres and has been commonly associated with high morbimortality. In Brazil, this resistance is mainly attributed to the spread of OXA-23-producing clones and, to a lesser extent, to OXA-143-producing clones. Here, we describe, for the first time, two OXA-72-producing A. baumannii isolates in southern Brazil to a broad spectrum of antibiotics, except polymyxin B and tigecycline. Molecular typing by multilocus sequence typing (MLST) demonstrated that both OXA-72-producing isolates belong to a new sequence type (ST), ST730, which was recently identified in OXA-23-producing A. baumannii isolates in São Paulo, Brazil. We demonstrate that the two A. baumannii ST730 isolates carrying blaOXA-72share a common ancestral origin with the blaOXA-23producers in Brazil. This observation reinforces the importance of strain-typing methods in order to clarify the dynamics of the emergence of new clones in a geographic region.
authors.affiliation: Universidade Federal do Rio Grande do Sul, Faculdade de Farmácia, Programa de Pós-Graduação em Ciências Farmacêuticas, Porto Alegre, RS, Brasil.|Hospital de Clínicas de Porto Alegre, Centro de Pesquisa Experimental, Laboratório de Pesquisa em Resistência Bacteriana, Porto Alegre, RS, Brasil.
authors.forename: Mariana
authors.initials: M
authors.lastname: Pagano
authors.affiliation: Universidade Federal do Rio Grande do Sul, Faculdade de Farmácia, Programa de Pós-Graduação em Ciências Farmacêuticas, Porto Alegre, RS, Brasil.|Hospital de Clínicas de Porto Alegre, Centro de Pesquisa Experimental, Laboratório de Pesquisa em Resistência Bacteriana, Porto Alegre, RS, Brasil.
authors.forename: Franciéli P
authors.initials: FP
authors.lastname: Rozales
authors.affiliation: Hospital de Clínicas de Porto Alegre, Centro de Pesquisa Experimental, Laboratório de Pesquisa em Resistência Bacteriana, Porto Alegre, RS, Brasil.
authors.forename: Diego
authors.initials: D
authors.lastname: Bertolini
authors.affiliation: Laboratório Fleury, Porto Alegre, RS, Brasil.
authors.forename: Lisiane
authors.initials: L
authors.lastname: Rocha
authors.affiliation: Laboratório Fleury, Porto Alegre, RS, Brasil.
authors.forename: Jorge Lm
authors.initials: JL
authors.lastname: Sampaio
authors.affiliation: Universidade Federal do Rio Grande do Sul, Faculdade de Farmácia, Programa de Pós-Graduação em Ciências Farmacêuticas, Porto Alegre, RS, Brasil.|Hospital de Clínicas de Porto Alegre, Centro de Pesquisa Experimental, Laboratório de Pesquisa em Resistência Bacteriana, Porto Alegre, RS, Brasil.
authors.forename: Afonso L
authors.initials: AL
authors.lastname: Barth
authors.affiliation: Hospital de Clínicas de Porto Alegre, Centro de Pesquisa Experimental, Laboratório de Pesquisa em Resistência Bacteriana, Porto Alegre, RS, Brasil.|Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Microbiologia Agrícola e do Ambiente, Porto Alegre, RS, Brasil.
authors.forename: Andreza F
authors.initials: AF
authors.lastname: Martins
mesh_terms: D040981:Acinetobacter baumannii / Q000201:enzymology / Q000235:genetics*; D000368:Aged; D001426:Bacterial Proteins / Q000235:genetics; D001938:Brazil; D024881:Drug Resistance, Bacterial / Q000235:genetics; D005798:Genes, Bacterial / Q000235:genetics*; D006801:Humans; D008297:Male; D058885:Multilocus Sequence Typing; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D001618:beta-Lactamases