title: [Current Status of Translational Research on Functional Dyspepsia].
abstract: Functional dyspepsia (FD) has a diverse pathophysiology and treatment is difficult. Translational research to understand its pathophysiology is underway. Hormonal factors, including ghrelin, seem promising, offering an understanding of appetite and eating. Functional MRI brain study can expand our knowledge of the brain-gut axis. Finally, immune systems research, including mast cells, can help with comprehensive understanding of FD. The clinical approaches based on these translational research projects are necessary to improve understanding of FD, leading to more effective treatment.
authors.affiliation: Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan, Korea.|Department of Gastroenterology, Ulsan University Hospital, Ulsan, Korea.
authors.forename: Jae Ho
authors.initials: JH
authors.lastname: Park
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.
authors.forename: Jong Wook
authors.initials: JW
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan, Korea.|Department of Gastroenterology, Gangneung Asan Hospital, Gangneung, Korea.
authors.forename: Jong Kyu
authors.initials: JK
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
authors.forename: Cheol Min
authors.initials: CM
authors.lastname: Shin
authors.affiliation: Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan, Korea.|Department of Gastroenterology, Asan Medical Center, Seoul, Korea.
authors.forename: Kee Wook
authors.initials: KW
authors.lastname: Jung
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging; D004415:Dyspepsia / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D054439:Ghrelin / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D008407:Mast Cells / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D057170:Translational Research, Biomedical
chemical_list: D054439:Ghrelin
keywords: Functional dyspepsia; Translational medical research