title: Distribution of lung blood on modified bilateral Glenn shunt evaluated by Tc-99m-MAA lung perfusion scintigraphy: A retrospective study.
abstract: The aim of the present study was to determine the distribution of lung blood in a modified bilateral Glenn procedure designed in our institute with lung perfusion scintigraphy. Sixteen consecutive patients who underwent modified bilateral Glenn operation from 2011 to 2014 were enrolled in the study. The control group consisted of 7 patients who underwent bidirectional Glenn shunt. Radionuclide lung perfusion scintigraphy was performed using Tc-99m-macro aggregated albumin (MAA) in all patients. For the patients in modified bilateral Glenn group, the time at which the radioactivity accumulation peaked did not differ significantly between the right and left lung field (t = 0.608, P = 0.554). The incidence of perfusion abnormality in each lung lobe also did not differ significantly (P = 0.426 by Fisher exact test). The radioactive counts were higher in the right lung than in the left lung, but the difference was not statistically significant (t = 1.502, P = 0.157). Radioactive perfusion in the lower lung field was significantly greater than that in the upper field (t = 4.368, P < 0.001). Compared with that in the bidirectional Glenn group, the ratio of radioactivity in the right lung to that in left lung was significantly lower in the modified bilateral Glenn group (t = 3.686, P = 0.002). Lung perfusion scintigraphy confirmed the benefit of the modified bilateral Glenn shunt with regard to more balanced blood perfusion in both lungs.
authors.affiliation: Department of Mechanics and Engineering Science, Fudan University, Shanghai Department of Nuclear Medicine, The 88th Hospital of Jinan Military Region, Taian Institute of Cardiovascular Disease, General Hospital of Jinan Military Region, Jinan, Shandong Dongfang Hospital, Tongji University, Shanghai, China.
authors.forename: Biao
authors.initials: B
authors.lastname: Si
authors.forename: Zhao-Sheng
authors.initials: ZS
authors.lastname: Luan
authors.forename: Tong-Jian
authors.initials: TJ
authors.lastname: Wang
authors.forename: Yan-Song
authors.initials: YS
authors.lastname: Ning
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.forename: Meng
authors.initials: M
authors.lastname: Zhu
authors.forename: Zhong-Min
authors.initials: ZM
authors.lastname: Liu
authors.forename: Guang-Hong
authors.initials: GH
authors.lastname: Ding
authors.forename: Bin
authors.initials: B
authors.lastname: Qiao
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D018729:Fontan Procedure / Q000379:methods*; D006801:Humans; D008168:Lung / Q000098:blood supply* / Q000000981:diagnostic imaging*; D008297:Male; D055420:Perfusion Imaging / Q000379:methods*; D019275:Radiopharmaceuticals / Q000008:administration & dosage*; D012189:Retrospective Studies; D013668:Technetium Tc 99m Aggregated Albumin / Q000008:administration & dosage*
chemical_list: D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin