title: Effect of epigallocatechin-3-o-gallate and quercetin on the cryopreservation of cartilage tissue.
abstract: The effects of epigallocatechin-3-o-gallate (EGCG) and quercetin on the contents of extracellular matrix (ECM) in porcine cartilage at 4 °C were investigated. The addition of quercetin at 0.01 mM for the incubation of porcine cartilage disks at 4 °C for 2 week could suppress the decrease in ECM and the compliance of the disks, markedly greater than those of EGCG (1.0 mM).
authors.affiliation: a Division of Biotechnology and Macromolecular Chemistry, Graduate School of Engineering , Hokkaido University , Sapporo , Japan.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Kasai
authors.affiliation: b School of Health and Sports Sciences , Mukogawa Women's University , Nishinomiya , Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Mera
authors.affiliation: b School of Health and Sports Sciences , Mukogawa Women's University , Nishinomiya , Japan.|c Graduate School of Biomedical Sciences , Hiroshima University , Hiroshima , Japan.
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Wakitani
authors.affiliation: d Department of Biomedical Engineering , Doshisha University , Kyotanabe , Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Morita
authors.affiliation: e Field of Medical Engineering, Division of Mechanical Engineering and Science, Graduate School of Engineering , Kyoto University , Kyoto , Japan.
authors.forename: Naohide
authors.initials: N
authors.lastname: Tomita
authors.affiliation: a Division of Biotechnology and Macromolecular Chemistry, Graduate School of Engineering , Hokkaido University , Sapporo , Japan.
authors.forename: Mutsumi
authors.initials: M
authors.lastname: Takagi
mesh_terms: D000818:Animals; D002356:Cartilage / Q000166:cytology* / Q000187:drug effects*; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D015925:Cryopreservation; D004305:Dose-Response Relationship, Drug; D005109:Extracellular Matrix / Q000187:drug effects / Q000378:metabolism; D010766:Phosphorylation / Q000187:drug effects; D011794:Quercetin / Q000494:pharmacology*; D013552:Swine
chemical_list: D002392:Catechin; D011794:Quercetin; C045651:epigallocatechin gallate
keywords: cartilage; cryopreservation; mesenchymal stem cells; quercetin