title: [Progress on the role of Toll-like receptors in Candida albicans infections].
abstract: Toll like receptors (TLRs) are expressed mainly on innate immunocytes such as dendritic cells and macrophages, and may have the potential to recognize and bind to pathogen-associated molecular patterns (PAMPs) from Candida albicans, thereby triggering the downstream signals. The genetic polymorphism of TLRs is associated with susceptibility to Candida albicans. The activation of TLRs by PAMPs from Candida albicans can induce the production of proinflammatory cytokines that play key roles in the anti-infection of Candida albicans. However, in order to evade the immune response of host,Candida albicans can also change its bacterial phase. Understanding of the interaction between TLRs and Candida albicans will provide novel evidence to further clarify the mechanisms of anti-fungal immune response.
authors.affiliation: Zhejiang University City College School of Medicine, Hangzhou 310015, China;Department of Pathogen Biology, Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Yun
authors.affiliation: Zhejiang University City College School of Medicine, Hangzhou 310015, China. jppan@zucc.edu.cn.
authors.forename: Pan
authors.initials: P
authors.lastname: Jianping
mesh_terms: D002176:Candida albicans / Q000472:pathogenicity*; D002177:Candidiasis / Q000276:immunology*; D016207:Cytokines; D003713:Dendritic Cells; D006801:Humans; D008264:Macrophages; D051193:Toll-Like Receptors / Q000502:physiology*
chemical_list: D016207:Cytokines; D051193:Toll-Like Receptors