title: Hydrogel-Based Controlled Delivery Systems for Articular Cartilage Repair.
abstract: Delivery of bioactive factors is a very valuable strategy for articular cartilage repair. Nevertheless, the direct supply of such biomolecules is limited by several factors including rapid degradation, the need for supraphysiological doses, the occurrence of immune and inflammatory responses, and the possibility of dissemination to nontarget sites that may impair their therapeutic action and raise undesired effects. The use of controlled delivery systems has the potential of overcoming these hurdles by promoting the temporal and spatial presentation of such factors in a defined target. Hydrogels are promising materials to develop delivery systems for cartilage repair as they can be easily loaded with bioactive molecules controlling their release only where required. This review exposes the most recent technologies on the design of hydrogels as controlled delivery platforms of bioactive molecules for cartilage repair.
authors.affiliation: Center of Experimental Orthopaedics, Saarland University Medical Center, Homburg, 66421 Saar, Germany.
authors.forename: Ana
authors.identifier: 0000-0003-1682-498X
authors.initials: A
authors.lastname: Rey-Rico
authors.affiliation: Center of Experimental Orthopaedics, Saarland University Medical Center, Homburg, 66421 Saar, Germany; Department of Orthopaedic Surgery, Saarland University Medical Center, Homburg, 66421 Saar, Germany.
authors.forename: Henning
authors.initials: H
authors.lastname: Madry
authors.affiliation: Center of Experimental Orthopaedics, Saarland University Medical Center, Homburg, 66421 Saar, Germany.
authors.forename: Magali
authors.identifier: 0000-0003-0323-8922
authors.initials: M
authors.lastname: Cucchiarini
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000293:injuries* / Q000378:metabolism* / Q000473:pathology; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D020100:Hydrogels / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D020100:Hydrogels