title: Primary Marginal Zone Lymphoma in the Posterior Mediastinum with Pleural Involvement.
abstract: We herein report a case of primary marginal zone lymphoma (MZL) of the posterior mediastinum in an 84-year-old woman. Computed tomography of the chest showed a posterior mediastinal mass in the right thoracic paravertebral region with right pleural effusion. Pathological findings of a surgical biopsy from the posterior mediastinum, along with immunohistochemical and flow cytometric results, indicated MZL. The patient was treated with chemotherapy and radiation therapy for the mediastinal lesion and achieved complete remission. A relapse occurred 3 months after the initial treatment regimen. However, a second relapse has not occurred more than 2 years after second-line chemotherapy. This is the first case of MZL originating in the posterior mediastinum.
authors.affiliation: Department of Laboratory Medicine and Pathology, National Hospital Organization Kinki-chuo Chest Medical Center, Japan.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Shimizu
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Inoue
authors.forename: Tomoki
authors.initials: T
authors.lastname: Utsumi
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Okuma
authors.forename: Tomoya
authors.initials: T
authors.lastname: Kawaguchi
authors.forename: Takahiko
authors.initials: T
authors.lastname: Kasai
authors.forename: Satoru
authors.initials: S
authors.lastname: Munakata
authors.forename: Masaru
authors.initials: M
authors.lastname: Shibano
authors.forename: Shinji
authors.initials: S
authors.lastname: Atagi
mesh_terms: D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols; D001706:Biopsy; D005047:Etoposide / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018442:Lymphoma, B-Cell, Marginal Zone / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D008479:Mediastinal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D008482:Mediastinum / Q000473:pathology*; D009364:Neoplasm Recurrence, Local; D010879:Piperazines / Q000627:therapeutic use*; D010994:Pleura / Q000473:pathology*; D012074:Remission Induction; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D010879:Piperazines; D005047:Etoposide; C057773:sobuzoxane