title: Effect of balance Solution on the Peritoneal Membrane in Automated Peritoneal Dialysis.
abstract: Interference of conventional peritoneal dialysis fluids (cPDFs) with peritoneal membrane cell functions may be attributed to the dialysis fluid's low pH, high glucose concentration, and/or the presence of glucose degradation products (GDPs), the last of which leads to higher levels of advanced glycation end-products (AGEs). It has been suggested that the peritoneal membrane might be better preserved by using biocompatible solutions, including cancer antigetn 125 (CA125). This prospective, open-label, multicentre, randomized, controlled, cross-over phase IV study compared the in vivo biocompatibility of a neutral-pH, low-GDP peritoneal dialysis (PD) solution (balance) with a cPDF in automated PD (APD) patients. Our study revealed a significantly increased appearance rate and concentration of CA125 in the peritoneal effluent of APD patients treated with the neutral-pH, low-GDP solution balance versus a conventional PD solution.
authors.affiliation: Clinical Research, Fresenius Medical Care Deutschland GmbH, Bad Homburg, Germany tatiana.de-los-rios@fmc-ag.com.
authors.forename: Tatiana
authors.initials: T
authors.lastname: De Los Ríos
authors.affiliation: Nephrology, University Hospital of Albacete, Albacete, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Pérez-Martínez
authors.affiliation: Nephrology, Hospital Universitario Puerta de Hierro, Madrid, Spain.
authors.forename: Jose
authors.initials: J
authors.lastname: Portoles
authors.affiliation: Nephrology, Centrum Dializ Fresenius Nephrocare, Gdansk, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Lichodziejewska-Niemierko
authors.affiliation: Nephrology, Hospital Universitario Ramón y Cajal, Madrid, Spain.
authors.forename: Maite
authors.initials: M
authors.lastname: Rivera
authors.affiliation: Nephrology, Klinika Nefroloqii, Lodz, Poland.
authors.forename: Michał
authors.initials: M
authors.lastname: Nowicki
authors.affiliation: Nephrology, Klinika Nefroloqii, Lodz, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Książek
authors.affiliation: Nephrology, Hospital Universitario Fundación Alcorcón, Alcorcón, Spain.
authors.forename: Ana María
authors.initials: AM
authors.lastname: Tato
authors.affiliation: Clinical Research, Fresenius Medical Care Deutschland GmbH, Bad Homburg, Germany.
authors.forename: Christine
authors.initials: C
authors.lastname: Bohnhorst
authors.affiliation: Dept. of Nephrology, Ospedale Umberto I, Rome, Italy.
authors.forename: Mariano
authors.initials: M
authors.lastname: Feriani
mesh_terms: D000328:Adult; D001331:Automation; D001639:Bicarbonates / Q000032:analysis; D001672:Biocompatible Materials / Q000737:chemistry*; D018394:CA-125 Antigen / Q000378:metabolism; D016001:Confidence Intervals; D003404:Creatinine / Q000652:urine; D018592:Cross-Over Studies; D015314:Dialysis Solutions / Q000737:chemistry*; D005260:Female; D005947:Glucose / Q000032:analysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007676:Kidney Failure, Chronic / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects / Q000379:methods*; D010537:Peritoneum / Q000187:drug effects* / Q000378:metabolism; D011446:Prospective Studies; D014508:Urea / Q000652:urine; D014882:Water-Electrolyte Balance / Q000502:physiology*
chemical_list: D001639:Bicarbonates; D001672:Biocompatible Materials; D018394:CA-125 Antigen; D015314:Dialysis Solutions; D014508:Urea; D003404:Creatinine; D005947:Glucose
keywords: Biocompatibility; cancer antigen 125; pH neutral; peritoneal dialysis fluids; residual renal function; ultrafiltration