title: RNA Regulators: Formidable Modulators of Yersinia Virulence.
abstract: A large repertoire of RNA-based regulatory mechanisms, including a plethora of cis- and trans-acting noncoding RNAs (ncRNAs), sensory RNA elements, regulatory RNA-binding proteins, and RNA-degrading enzymes have been uncovered lately as key players in the regulation of metabolism, stress responses, and virulence of the genus Yersinia. Many of them are strictly controlled in response to fluctuating environmental conditions sensed during the course of the infection, and certain riboregulators have already been shown to be crucial for virulence. Some of them are highly conserved among the family Enterobacteriaceae, while others are genus-, species-, or strain-specific and could contribute to the difference in Yersinia pathogenicity. Importantly, the analysis of Yersinia riboregulators has not only uncovered crucial elements and regulatory mechanisms governing host-pathogen interactions, it also revealed exciting new venues for the design of novel anti-infectives.
authors.affiliation: Department of Molecular Infection Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Nuss
authors.affiliation: Department of Molecular Infection Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
authors.forename: Ann Kathrin
authors.initials: AK
authors.lastname: Heroven
authors.affiliation: Department of Molecular Infection Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany. Electronic address: petra.dersch@helmholtz-hzi.de.
authors.forename: Petra
authors.initials: P
authors.lastname: Dersch
mesh_terms: D000818:Animals; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics*; D054884:Host-Pathogen Interactions; D006801:Humans; D016372:RNA, Antisense / Q000235:genetics*; D012329:RNA, Bacterial / Q000235:genetics*; D022661:RNA, Untranslated / Q000235:genetics*; D058928:Riboswitch / Q000235:genetics; D014774:Virulence / Q000235:genetics; D037521:Virulence Factors / Q000235:genetics; D015007:Yersinia / Q000235:genetics* / Q000472:pathogenicity*
chemical_list: D016372:RNA, Antisense; D012329:RNA, Bacterial; D022661:RNA, Untranslated; D058928:Riboswitch; D037521:Virulence Factors
keywords: Csr; RNA thermometers; Yersinia; gene regulation; regulated RNA degradation; regulatory RNAs; riboswitches; thermosensing; virulence