title: Effect of Alpinia officinarum Hance alcohol extracts on primary dysmenorrheal.
abstract: OBJECTIVE
  To study the effect of Alpinia officinarum Hance (A. officinarum) 80% alcohol extract on the primary dysmenorrhea.
  
  
  METHODS
  A. officinarum 80% alcohol extract were enriched by macroporous adsorption resins. Female mice of primary dysmenorrhea model were established by oxytocin induction; the effects of A. officinarum 80% alcohol extract on primary dysmenorrhea were observed by body twist method; and the homogenate level of prostaglandin F2α (PGF2α), prostaglandin E2 (PGE2) and Ca(2+) in the uterus were observed in oxytocin-induced female mice.
  
  
  RESULTS
  The writhing frequency of primary dysmenorrhea mice was significantly decreased after treatment of A. officinarum 80% alcohol extract and the level of PGF2α, PGE2 and Ca(2+) in mice uterus was significantly decreased (P < 0.05, P < 0.01) in groups of mice treated with middle and high dosage of A. officinarum 80% alcohol extract compared with that of model group.
  
  
  CONCLUSIONS
  These findings suggest that A. Officinarum 80% alcohol extract can significantly relieve primary dysmenorrhea.
authors.affiliation: School of Pharmaceutical Sciences, Hainan Medical University, Haikou 571101, Hainan, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Huang
authors.affiliation: School of Pharmaceutical Sciences, Hainan Medical University, Haikou 571101, Hainan, China.
authors.forename: Jun-Qing
authors.initials: JQ
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Hainan Medical University, Haikou 571101, Hainan, China.
authors.forename: You-Bin
authors.initials: YB
authors.lastname: Li
authors.affiliation: School of Pharmaceutical Sciences, Hainan Medical University, Haikou 571101, Hainan, China.
authors.forename: Mi
authors.initials: M
authors.lastname: Liu
authors.affiliation: School of Pharmaceutical Sciences, Hainan Medical University, Haikou 571101, Hainan, China.
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Deng
authors.affiliation: School of Pharmaceutical Sciences, Hainan Medical University, Haikou 571101, Hainan, China.
authors.forename: Yu-Chao
authors.initials: YC
authors.lastname: Luo
authors.affiliation: School of Pharmaceutical Sciences, Hainan Medical University, Haikou 571101, Hainan, China.
authors.forename: Yin-Feng
authors.initials: YF
authors.lastname: Tan
authors.affiliation: School of Pharmaceutical Sciences, Hainan Medical University, Haikou 571101, Hainan, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Hou
authors.affiliation: School of Pharmaceutical Sciences, Hainan Medical University, Haikou 571101, Hainan, China.
authors.forename: Gui-Wei
authors.initials: GW
authors.lastname: Yao
authors.affiliation: School of Pharmaceutical Sciences, Hainan Medical University, Haikou 571101, Hainan, China. Electronic address: puer6@163.com.
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Guan
keywords: Alpinia officinarum Hance alcohol extracts; Primary dysmenorrhea; Relieve