title: Current Concepts in the Pathogenesis of Takotsubo Syndrome.
abstract: Takotsubo syndrome is typically characterized by acute reversible impairment of apical and mid -left ventricular systolic function. The pathophysiology is complex and remains to be completely understood. A catecholamine surge appears to be a central feature. Patients with prior history of psychiatric disorders have a predisposition. The putative role of a switch in b-adrenoceptor signalling resulting in negative inotropy remains uncertain. Downregulation of noncritical cellular functions may offer some protection in preventing irreversible cellular necrosis. Microvascular function is a common occurrence in these patients.
authors.affiliation: Cardiovascular and Cell Sciences Research Institute, St. George's, University of London, Cranmer Terrace, London SW17 0RE, UK.
authors.forename: Rupert
authors.initials: R
authors.lastname: Williams
authors.affiliation: Cardiovascular Division, Rayne Institute, King's College London, St Thomas' Hospital, Westminster Bridge Road, London SE1 7EH, UK.
authors.forename: Satpal
authors.initials: S
authors.lastname: Arri
authors.affiliation: Cardiovascular and Cell Sciences Research Institute, St. George's, University of London, Cranmer Terrace, London SW17 0RE, UK. Electronic address: aprasad@sgul.ac.uk.
authors.forename: Abhiram
authors.initials: A
authors.lastname: Prasad
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002395:Catecholamines / Q000378:metabolism; D015897:Comorbidity; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D054549:Takotsubo Cardiomyopathy / Q000209:etiology* / Q000378:metabolism / Q000473:pathology*
chemical_list: D002395:Catecholamines
keywords: Apical ballooning syndrome; Catecholamine; Pathophysiology; Takotsubo syndrome