title: Associations Between Neurocognitive Impairment and Biomarkers of Poor Physiologic Reserve in a Clinic-Based Sample of Older Adults Living with HIV.
abstract: Data from a cross-sectional study of a clinic-based sample of older people living with HIV (PLWH; n = 100) were used to examine associations between biomarkers of physical health and neurocognitive impairment (NCI). In this sample, anemia, chronic kidney disease (CKD) stages 4-5, and hypocalcemia were associated with impairment in executive functioning or processing speed. Furthermore, participants with anemia were more likely to have CD4+ T cell counts <200 cells/mm3(χ2[1] = 19.57, p < .001); hypocalcemia (χ2[1] = 17.55, p < .001); and CKD 4-5 (χ2[2] = 10.12, p = .006). Black and Hispanic participants were more likely to be anemic compared to other races and ethnicities (χ2[3] = 12.76, p = .005). Common medical conditions (e.g., anemia, hypocalcemia, CKD) should be investigated as potential contributors to NCI in older PLWH. Additionally, laboratory testing in racial/ethnic minority PLWH may help inform NCI screening.
authors.forename: Kalvin C
authors.initials: KC
authors.lastname: Yu
authors.forename: Paul A
authors.initials: PA
authors.lastname: D'Avanzo
authors.forename: Leigh
authors.initials: L
authors.lastname: Nesheiwat
authors.forename: Richard E
authors.initials: RE
authors.lastname: Greene
authors.forename: Antonio
authors.initials: A
authors.lastname: Urbina
authors.forename: Perry N
authors.initials: PN
authors.lastname: Halkitis
authors.forename: Farzana
authors.initials: F
authors.lastname: Kapadia
mesh_terms: D000368:Aged; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D015415:Biomarkers; D015496:CD4-Positive T-Lymphocytes; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000523:psychology*; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000097:blood / Q000453:epidemiology; D009483:Neuropsychological Tests; D019562:Viral Load
chemical_list: D044966:Anti-Retroviral Agents; D015415:Biomarkers
keywords: HIV; neurocognitive impairment; screening