title: Baseline Body Composition in Prepubertal Short Stature Children with Severe and Moderate Growth Hormone Deficiency.
abstract: Objective. To compare body composition parameters in short children with severe versus moderate and no growth hormone deficiency (GHD). Design and Method. 61 children (40 boys) were studied. Height SDS, BMI Z-score, waist/height ratio (W/HtR), and body composition parameters (BIA) as fat tissue (FAT%), fat-free mass (FFM%), predicted muscle mass (PMM%), and total body water (TBW%) were evaluated. GH secretion in the overnight profile and two stimulation tests and insulin-like growth factor 1 (IGF-1) level were measured. Results. Overall, in 16 (26%) moderate (7.0 > peak GH < 10 ng/mL) and in 11 (18%) severe (GH ≤ 7.0 ng/mL) GHD was diagnosed. In children with sGHD BMI Z-score, W/HtR and FAT% were significantly higher, while FFM%, PMM%, and TBW% were significantly lower versus mGHD and versus noGHD subgroups. No significant differences between mGHD and noGHD were found. There were no differences in height SDS and IGF-1 SDS between evaluated subgroups. Night GH peak level correlated significantly with FAT%, FFM%, PMM%, and TBW%, (p < 0.05) in the entire group. Conclusions. Only sGHD is associated with significant impairment of body composition. Body composition analysis may be a useful tool in distinguishing between its severe and moderate form of GHD.
authors.affiliation: School of Medicine in Katowice, Department of Pediatrics and Pediatric Endocrinology, Medical University of Silesia, Katowice, Poland.
authors.forename: Pawel
authors.identifier: 0000-0002-8943-7051
authors.initials: P
authors.lastname: Matusik
authors.affiliation: Scientific Society of Medical Students, Medical University of Silesia, Katowice, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Klesiewicz
authors.affiliation: Scientific Society of Medical Students, Medical University of Silesia, Katowice, Poland.
authors.forename: Karolina
authors.identifier: 0000-0001-6315-0987
authors.initials: K
authors.lastname: Klos
authors.affiliation: Scientific Society of Medical Students, Medical University of Silesia, Katowice, Poland.
authors.forename: Martyna
authors.identifier: 0000-0003-1914-527X
authors.initials: M
authors.lastname: Stasiulewicz
authors.affiliation: Scientific Society of Medical Students, Medical University of Silesia, Katowice, Poland.
authors.forename: Aleksandra
authors.identifier: 0000-0003-0879-2738
authors.initials: A
authors.lastname: Barylak
authors.affiliation: Scientific Society of Medical Students, Medical University of Silesia, Katowice, Poland.
authors.forename: Patrycja
authors.identifier: 0000-0003-1378-9410
authors.initials: P
authors.lastname: Nazarkiewicz
authors.affiliation: School of Medicine in Katowice, Department of Pediatrics and Pediatric Endocrinology, Medical University of Silesia, Katowice, Poland.
authors.forename: Ewa
authors.identifier: 0000-0002-2693-7622
authors.initials: E
authors.lastname: Malecka-Tendera