title: Prognostic Value of Focal Adhesion Kinase (FAK) in Human Solid Carcinomas: A Meta-Analysis.
abstract: BACKGROUND
  Recently, the number of reports on focal adhesion kinase (FAK) as a vital therapeutic target in solid carcinomas has increased; however, the prognostic role of FAK status remains poorly understood. This study aims to evaluate the prognostic effect of FAK by means of a meta-analysis.
  
  
  METHODS
  We performed a systematic literature search in order to examine the correlation between expression of FAK and overall survival(OS). The hazard ratio (HR) of OS was used to measure survival. A random-effects model was used to pool study statistics. Sensitivity and publication bias analyses were also conducted.
  
  
  RESULTS
  Thirty eligible studies involving 4702 patients were included. The median expression rate of FAK was 54%. Meta-analysis of the HRs demonstrated that high FAK expression was associated with worse OS (average HR = 2.073, 95%confidence interval[CI]:1.712-2.510, p = 0.000). Regarding cancer type, FAK was associated with worse OS in gastric cancer (HR = 2.646,95% CI:1.743-4.017, p = 0.000), hepatocellular carcinoma (HR = 1.788,95% CI:1.228-2.602, p = 0.002), ovarian cancer (HR = 1.815, 95% CI: 1.193-2.762, p = 0.005), endometrial cancer (HR = 4.149, 95% CI:2.832-6.079, p = 0.000), gliomas (HR = 2.650, 95% CI: 1.205-5.829, p = 0.015), and squamous cell carcinoma (HR = 1,696, 95% CI: 1.030-2.793, p = 0.038). No association was found between HR and disease staging according to our meta-regression analysis.
  
  
  CONCLUSIONS
  Our study shows that high expression of FAK is associated with a worse OS in patients with carcinomas, but the association between FAK and prognosis varies according to cancer type. The value of FAK status in clinical prognosis in cancer needs further research.
authors.affiliation: Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Xiao-Qing
authors.initials: XQ
authors.lastname: Zeng
authors.affiliation: Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.affiliation: Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Ma
authors.affiliation: Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Yu-Jen
authors.initials: YJ
authors.lastname: Tseng
authors.affiliation: Department of Biostatistics, Fudan University, Shanghai, China.|Evidence-based Medicine Center, Fudan University, Shanghai, China.
authors.forename: Nai-Qing
authors.initials: NQ
authors.lastname: Zhao
authors.affiliation: Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, China.|Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, China.|Evidence-based Medicine Center, Fudan University, Shanghai, China.
authors.forename: Shi-Yao
authors.initials: SY
authors.lastname: Chen
mesh_terms: D005260:Female; D051416:Focal Adhesion Protein-Tyrosine Kinases / Q000378:metabolism*; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000201:enzymology* / Q000473:pathology; D011379:Prognosis
chemical_list: D051416:Focal Adhesion Protein-Tyrosine Kinases