title: Hypothyroidism Affects Olfactory Evoked Potentials.
abstract: Background. Objective electrophysiological methods for investigations of the organ of smell consist in recordings of olfactory cortex responses to specific, time restricted odor stimuli. In hypothyroidism have impaired sense of smell.Material and Methods. Two groups: control of 31 healthy subjects and study group of 21 with hypothyroidism. The inclusion criterion for the study group was the TSH range from 3.54 to 110μIU/mL.Aim. Assessment of the latency time of evoked responses from the olfactory nerve N1 and the trigeminal nerve N5 using two smells of mint and anise in hypothyroidism.Results. The smell perception in subjective olfactory tests was normal in 85% of the hypothyroid group. Differences were noticed in the objective tests. The detailed intergroup analysis of latency times of recorded cortical responsesPN5andPN1performed by means between the groups of patients with overt clinical hypothyroidism versus subclinical hypothyroidism demonstrated a significant difference (p< 0.05) whereas no such differences were found between the control group versus subclinical hypothyroidism group (p> 0.05).Conclusion. We can conclude that registration of cortex potentials at irritation of olfactory and trigeminal nerves offers possibilities for using this method as an objective indicator of hypothyroidism severity and prognostic process factor.
authors.affiliation: Department of Biophysics, ul. Fredry 10, 61-701 Poznań, Poland.
authors.forename: Teodor
authors.initials: T
authors.lastname: Świdziński
authors.affiliation: Department of Conservative Dentistry and Periodontology, University of Medical Sciences, ul. Bukowska 70, 60-567 Poznań, Poland.
authors.forename: Kamila
authors.identifier: 0000-0003-1734-4865
authors.initials: K
authors.lastname: Linkowska-Świdzińska
authors.affiliation: Department of Phoniatrics and Audiology, University of Medical Sciences, ul. Przybyszewskiego 49, 60-355 Poznań, Poland.
authors.forename: Hanna
authors.initials: H
authors.lastname: Czerniejewska-Wolska
authors.affiliation: Department of Phoniatrics and Audiology, University of Medical Sciences, ul. Przybyszewskiego 49, 60-355 Poznań, Poland.
authors.forename: Bożena
authors.initials: B
authors.lastname: Wiskirska-Woźnica
authors.affiliation: Department of Endocrinology, Metabolism and Internal Medicine, University of Medical Sciences, ul. Przybyszewskiego 49, 60-355 Poznań, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Owecki
authors.affiliation: Department of Organization and Management in Health Care, University of Medical Sciences, ul. Smoluchowskiego 11, 60-179 Poznań, Poland.
authors.forename: Maria Danuta
authors.initials: MD
authors.lastname: Głowacka
authors.affiliation: Department of Organization and Management in Health Care, University of Medical Sciences, ul. Smoluchowskiego 11, 60-179 Poznań, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Frankowska
authors.affiliation: Department of Endocrinology, Metabolism and Internal Medicine, University of Medical Sciences, ul. Przybyszewskiego 49, 60-355 Poznań, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Łącka
authors.affiliation: Department of Oral Rehabilitation, Division of Prosthodontics, University of Medical Sciences, ul. Bukowska 70, 60-567 Poznań, Poland.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Glapiński
authors.affiliation: Department of Oral Rehabilitation, Division of Prosthodontics, University of Medical Sciences, ul. Bukowska 70, 60-567 Poznań, Poland.
authors.forename: Zofia
authors.initials: Z
authors.lastname: Maciejewska-Szaniec
authors.affiliation: Department of Phoniatrics and Audiology, University of Medical Sciences, ul. Przybyszewskiego 49, 60-355 Poznań, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Świdziński