title: Skin aging in patients with acquired immunodeficiency syndrome.
abstract: To evaluate the histomorphometric skin changes over aging patients with autopsied acquired immunodeficiency syndrome (AIDS). In 29 skin fragments of autopsied elderly (older than 50 years) and nonelderly patients with AIDS, epidermal thickness, the number of layers, the diameter of cells, the percentage of collagen and elastic fibers in the dermis, and the number and morphology of Langerhans cells were assessed. Statistical analysis was performed by SigmaStat 2.03 program. The thickness of the epidermis (92.55 × 158.94 μm), the number of layers (7 × 9 layers), and the diameter of the cells (13.27 × 17.6 μm) were statistically lower among the elderly. The quantity of collagen fibers (9.68 × 14.11%) and elastic fibers (11.89 × 15.31%) was also significantly lower in the elderly. There was a decrease in total (10.61 × 12.38 cel/mm(2)) and an increase in immature Langerhans cells (6.31 × 4.98 cel/mm(2)) in elderly patients with AIDS. The aging of the skin of patients with AIDS is amended in different histomorphometric aspects, the epidermis constituents suffer less pronounced changes in normal aging, and the dermis has more intense changes in elastic fibers and collagen.
authors.affiliation: Biological and Natural Science Institute, General Pathology Discipline, Triângulo Mineiro Federal University (UFTM), Uberaba, MG, Brazil.
authors.forename: Grace Kelly Naves
authors.initials: GK
authors.lastname: de Aquino Favarato
authors.affiliation: Biological and Natural Science Institute, General Pathology Discipline, Triângulo Mineiro Federal University (UFTM), Uberaba, MG, Brazil.
authors.forename: Aline Cristina Souza
authors.initials: AC
authors.lastname: da Silva
authors.affiliation: Biological and Natural Science Institute, General Pathology Discipline, Triângulo Mineiro Federal University (UFTM), Uberaba, MG, Brazil.
authors.forename: Lívia Ferreira
authors.initials: LF
authors.lastname: Oliveira
authors.affiliation: Biological and Natural Science Institute, General Pathology Discipline, Triângulo Mineiro Federal University (UFTM), Uberaba, MG, Brazil.
authors.forename: Mara Lúcia
authors.initials: ML
authors.lastname: da Fonseca Ferraz
authors.affiliation: Biological and Natural Science Institute, General Pathology Discipline, Triângulo Mineiro Federal University (UFTM), Uberaba, MG, Brazil.
authors.forename: Vicente
authors.initials: V
authors.lastname: de Paula Antunes Teixeira
authors.affiliation: Biological and Natural Science Institute, General Pathology Discipline, Triângulo Mineiro Federal University (UFTM), Uberaba, MG, Brazil. Electronic address: camila@patge.uftm.edu.br.
authors.forename: Camila Lourencini
authors.initials: CL
authors.lastname: Cavellani
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis / Q000473:pathology*; D000328:Adult; D000368:Aged; D000375:Aging; D003094:Collagen / Q000378:metabolism; D004547:Elastic Tissue / Q000473:pathology; D004817:Epidermis / Q000473:pathology; D005260:Female; D006801:Humans; D007801:Langerhans Cells / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015595:Skin Aging / Q000473:pathology* / Q000502:physiology
chemical_list: D003094:Collagen
keywords: Acquired immunodeficiency syndrome; Aging; Epidermis; Skin