title: The effect of acotiamide on epigastric pain syndrome and postprandial distress syndrome in patients with functional dyspepsia.
abstract: The effect of acotiamide on gastrointestinal symptoms is undefined. The aim of this study is to evaluate the effect of acotiamide on abdominal symptoms in patients with functional dyspepsia. We retrospectively reviewed 51 patients treated with acotiamide. We evaluated patient quality of life using the Izumo scale that detects changes in quality of life caused by abdominal symptoms. Acotiamide ameliorated the symptoms of functional dyspepsia at one and three months (improved: 61% vs 80%, p=0.029 and resolved: 17% vs 33%, p=0.069). We then evaluated the effect of acotiamide on epigastric pain syndrome (EPS) (n=33) and postprandial distress syndrome (PDS) (n=41). Acotiamide treatment showed an early effect on rates of improvement (63%) and resolution (42%) of EPS symptoms at one month, maintained up to three months (69% and 39%, respectively). Both rates of improvement and resolution of PDS symptoms showed a significant increase from one month to three months (56% vs 78%, p=0.021 and 17% vs 46%, p=0.004, respectively). The severity of functional dyspepsia symptoms before treatment was significantly associated with failed resolution of functional dyspepsia symptoms (p=0.013). Acotiamide improves and resolves EPS symptoms as well as PDS symptoms. PDS symptoms take longer to resolve than EPS symptoms. J. Med. Invest. 63: 230-235, August, 2016.
authors.affiliation: Shinozaki Medical Clinic.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Shinozaki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Osawa
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Sakamoto
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Alan
authors.initials: A
authors.lastname: Kawarai Lefor
authors.forename: Hironori
authors.initials: H
authors.lastname: Yamamoto
mesh_terms: D015746:Abdominal Pain / Q000188:drug therapy*; D000328:Adult; D000368:Aged; D001549:Benzamides / Q000627:therapeutic use*; D004415:Dyspepsia / Q000188:drug therapy*; D005260:Female; D005764:Gastroesophageal Reflux / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period / Q000502:physiology*; D011788:Quality of Life; D012189:Retrospective Studies; D013577:Syndrome; D013844:Thiazoles / Q000627:therapeutic use*
chemical_list: D001549:Benzamides; D013844:Thiazoles; C410959:Z 338