title: Maternal Immunization with Pneumococcal Polysaccharide Vaccine: Persistence of Maternal Antibodies in Infants.
abstract: To evaluate the level and the persistence of maternal antibodies in infants after maternal immunization with pneumococcal polysaccharide vaccine (Pn23V).
  
  
  
  Pregnant women were assigned to two groups, during routine low-risk pre-natal visits. The first Group (VAC) received the Pn23V vaccine shortly after enrolment at 28 weeks or later, and the second Group (NO_VAC) received no vaccine. To investigate the antibody persistence, we collected blood samples from the mothers after 1 month of delivery and from the infants at 1 and 6 months of age.
  
  
  
  Antibody titers were measured for serotypes 1, 6B and 14. Geometric mean antibody concentrations of specific immunoglobulin G were significantly higher in the vaccinated group compared with unvaccinated controls for all three serotypes tested.
  
  
  
  Despite the antibody level's decline, at 6 months of age, proportions  >0.35 μg/ml remained higher in the infants of vaccinated mothers than controls for all three serotypes.
authors.affiliation: Faculdade Ciências Médicas Santa Casa de São Paulo, São Paulo, Brazil.
authors.forename: Eitan N
authors.initials: EN
authors.lastname: Berezin
authors.forename: Claudia C
authors.initials: CC
authors.lastname: Lopes
authors.affiliation: Faculdade de Saúde Publica Universidade de S. Paulo, São Paulo, Brazil.
authors.forename: Maria Regina A
authors.initials: MRA
authors.lastname: Cardoso
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood* / Q000276:immunology; D005260:Female; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007114:Immunization; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D011008:Pneumococcal Infections / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D022242:Pneumococcal Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D011247:Pregnancy; D012703:Serotyping / Q000379:methods; D013997:Time Factors; D014611:Vaccination; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D022242:Pneumococcal Vaccines
keywords: maternal vaccines; pneumococcal serotype.; pneumococcal vaccines