title: Secretion of full-length tau or tau fragments in a cell culture model.
abstract: Tau is a microtubule-associated protein that plays an important role in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease. Several studies have suggested that tau may be secreted to extracellular medium and may be responsible of spreading of neurodegeneration. The overexpression of tau in cultured non-neuronal cells leads to the secretion of this protein. The proline-rich region of tau may serve as a membrane-binding site during the secretion of the full-length tau molecule. Tau fragments lacking this proline-region are either not secreted or are secreted in a distinct manner to the full-length molecule.
authors.affiliation: Departamento de Anatomía Histología y Neurociencia, Facultad de Medicina UAM, 28029 Madrid, Spain.
authors.forename: Mar
authors.initials: M
authors.lastname: Pérez
authors.affiliation: Centro de Biología Molecular Severo Ochoa (CSIC-UAM), 28049 Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Cuadros
authors.affiliation: Centro de Biología Molecular Severo Ochoa (CSIC-UAM), 28049 Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain.
authors.forename: Félix
authors.initials: F
authors.lastname: Hernández
authors.affiliation: Centro de Biología Molecular Severo Ochoa (CSIC-UAM), 28049 Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain. Electronic address: javila@cbm.csic.es.
authors.forename: Jesús
authors.initials: J
authors.lastname: Avila
mesh_terms: D000818:Animals; D019556:COS Cells; D016923:Cell Death; D002522:Chlorocebus aethiops; D005110:Extracellular Space / Q000378:metabolism; D006801:Humans; D010446:Peptide Fragments / Q000235:genetics / Q000378:metabolism; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D016875:tau Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D010446:Peptide Fragments; D020033:Protein Isoforms; D016875:tau Proteins
keywords: Extracellular; Protein aggregation; Protein secretion; Tau fragments; Tau protein