title: The restorative role of annexin A1 at the blood-brain barrier.
abstract: Annexin A1 is a potent anti-inflammatory molecule that has been extensively studied in the peripheral immune system, but has not as yet been exploited as a therapeutic target/agent. In the last decade, we have undertaken the study of this molecule in the central nervous system (CNS), focusing particularly on the primary interface between the peripheral body and CNS: the blood-brain barrier. In this review, we provide an overview of the role of this molecule in the brain, with a particular emphasis on its functions in the endothelium of the blood-brain barrier, and the protective actions the molecule may exert in neuroinflammatory, neurovascular and metabolic disease. We focus on the possible new therapeutic avenues opened up by an increased understanding of the role of annexin A1 in the CNS vasculature, and its potential for repairing blood-brain barrier damage in disease and aging.
authors.affiliation: Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster, London, UK.
authors.forename: Simon
authors.initials: S
authors.lastname: McArthur
authors.affiliation: William Harvey Research Institute, School of Medicine and Dentistry, Queen Mary University, London, UK.
authors.forename: Rodrigo Azevedo
authors.initials: RA
authors.lastname: Loiola
authors.affiliation: William Harvey Research Institute, School of Medicine and Dentistry, Queen Mary University, London, UK.
authors.forename: Elisa
authors.initials: E
authors.lastname: Maggioli
authors.affiliation: Department of Basic Medical Sciences, Neuroscience and Sensory Organs, Bari University School of Medicine, Bari, Italy.
authors.forename: Mariella
authors.initials: M
authors.lastname: Errede
authors.affiliation: Department of Basic Medical Sciences, Neuroscience and Sensory Organs, Bari University School of Medicine, Bari, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Virgintino
authors.affiliation: William Harvey Research Institute, School of Medicine and Dentistry, Queen Mary University, London, UK. e.solito@qmul.ac.uk.
authors.forename: Egle
authors.identifier: http://orcid.org/0000-0001-5279-0049
authors.initials: E
authors.lastname: Solito
keywords: Annexin A1; Blood–brain barrier; Inflammation; Metabolism; Multiple sclerosis; Stroke