title: [INFLUENCE OF THE INTRA-ABDOMINAL HYPERTENSION ON THE BLOOD COAGULATION SYSTEM (EXPERIMENTAL STUDY)].
abstract: The analysis of the influence of the intra-abdominal hypertension on the blood coagulation system by carrying out an experimental research with laboratory animals is presented in article. After simulating intra-abdominal hypertension with different degree and exposition we made the laboratory research of blood coagulation system (fibrinogen, PTI, SFMC, APTT) and ELISA research on the concentration of the modern marker of thrombozis - D-dimer. The results in article clearly demonstrate that there is a direct linear dependence of level of fibrinogen and SFMC on degree of intra-abdominal hypertension, and the multidirectional changes of indicators with increase of intra-abdominal hypertension duration - towards hypercoagulation for 3-12 hours, and then by 24 o'clock - in the opposite direction towards hypocoagulation. Perhaps, it is explained with development of organ dysfunction and a coagulopathy of consumption. Indicator D-dimer has also direct linear dependence on the intra-abdominal hypertension level with contents peak at 3 hour exposition, and at all intra-abdominal hypertension levels, more than 2-fold rise of D-dimer level is statistically significant.
authors.affiliation: Karaganda State Medical University, Kazakhstan.
authors.forename: Y
authors.initials: Y
authors.lastname: Turgunov
authors.affiliation: Karaganda State Medical University, Kazakhstan.
authors.forename: D
authors.initials: D
authors.lastname: Matyushko
authors.affiliation: Karaganda State Medical University, Kazakhstan.
authors.forename: A
authors.initials: A
authors.lastname: Nurbekov
authors.affiliation: Karaganda State Medical University, Kazakhstan.
authors.forename: D
authors.initials: D
authors.lastname: Kaliyeva
authors.affiliation: Karaganda State Medical University, Kazakhstan.
authors.forename: A
authors.initials: A
authors.lastname: Alibekov
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D059325:Intra-Abdominal Hypertension / Q000097:blood*; D010314:Partial Thromboplastin Time; D011516:Prothrombin / Q000032:analysis; D051381:Rats; D013997:Time Factors
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; C011468:fibrinmonomer; D011516:Prothrombin; D005340:Fibrinogen