title: Intracerebral Stem Cell Administration Inhibits Relapse-like Alcohol Drinking in Rats.
abstract: Study describes the blockade of relapse-like alcohol drinking by mesenchymal stem cells (MSCs). High alcohol-intake bred rats consumed alcohol for 3 months and were subjected to repeated alcohol deprivations for 7-14 days, followed by alcohol reaccess. Upon reaccess, animals consumed 2.2 g alcohol/kg in 60 minutes. A single intra-cerebroventricular MSC administration inhibited relapse-like drinking up to 80-85% for 40 days (P < 0.001). An alcohol-use-disorder was prevented.
authors.affiliation: Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, University of Chile, Santiago, Chile yisrael@uchile.cl yedy.israel@vtr.net.
authors.forename: Yedy
authors.initials: Y
authors.lastname: Israel
authors.affiliation: Centro de Medicina Regenerativa, Facultad de Medicina Clínica Alemana-Universidad del Desarrollo, Santiago, Chile.
authors.forename: Fernando
authors.initials: F
authors.lastname: Ezquer
authors.affiliation: Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, University of Chile, Santiago, Chile.
authors.forename: María Elena
authors.initials: ME
authors.lastname: Quintanilla
authors.affiliation: Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, University of Chile, Santiago, Chile.
authors.forename: Paola
authors.initials: P
authors.lastname: Morales
authors.affiliation: Centro de Medicina Regenerativa, Facultad de Medicina Clínica Alemana-Universidad del Desarrollo, Santiago, Chile.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Ezquer
authors.affiliation: Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, University of Chile, Santiago, Chile.
authors.forename: Mario
authors.initials: M
authors.lastname: Herrera-Marschitz
mesh_terms: D000428:Alcohol Drinking / Q000378:metabolism* / Q000628:therapy*; D000818:Animals; D002470:Cell Survival / Q000502:physiology; D004195:Disease Models, Animal; D005260:Female; D057967:Infusions, Intraventricular; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D012008:Recurrence
chemical_list: D017382:Reactive Oxygen Species