title: Effect of Oral Pregabalin as Preemptive Analgesic in Patients Undergoing Lower Limb Orthopedic Surgeries under Spinal Anaesthesia.
abstract: BACKGROUND
  Conquering postoperative pain which has significant impact on the surgery outcome can be challenging for the clinicians. Pregabalin is a GABA analogue used for various neuropathic pain syndromes. Very few studies are there with the use of pregabalin as a preemptive analgesic for orthopedic surgeries.
  
  
  OBJECTIVE
  To compare pregabalin 150 mg with placebo for postoperative pain control in patients undergoing elective lower limb orthopedic surgeries under spinal anaesthesia and to assess any side effects.
  
  
  METHODS
  A randomized double blinded prospective study was undertaken. Ninety patients with ASA physical status I, II, aged between 18-50 years were enrolled in the study. One hour prior to spinal anaesthesia Group C - received colour matched empty capsules, Group P - received 150mg of oral pregabalin. Spinal anaesthesia was administered in sitting position in L3-L4 space with Inj. Bupivacaine heavy (0.5%) at a dose of 0.3mg/kg body weight with 20 mg being the maximum dose using 25 gauge spinal needle. Rescue analgesia was provided with using Inj. Diclofenac 1.5 mg/kg intramuscular.
  
  
  RESULTS
  Time for rescue analgesia (VAS score >3) was significantly increased in Group P than in Group C. The total dose of diclofenac required in the 24 hour postoperative period was significantly lower in Group P than in Group C. The sedation scores and patient satisfaction scores were also more in Group P than in Group C.
  
  
  CONCLUSIONS
  Preemptive pregabalin in an oral dose of 150 mg offers good postoperative analgesia in lower limb orthopedic surgeries under spinal anaesthesia.
authors.affiliation: Resident, Department of Anaesthesia, Sri Devaraj Urs Medical College , Tamaka, Kolar, India .
authors.forename: Bon
authors.initials: B
authors.lastname: Sebastian
authors.affiliation: Professor, Department of Anaesthesia, Sri Devaraj Urs Medical College , Tamaka, Kolar, India .
authors.forename: Anand Tippanna
authors.initials: AT
authors.lastname: Talikoti
authors.affiliation: Assistant Professor, Department of Anaesthesia, Sri Devaraj Urs Medical College , Tamaka, Kolar, India .
authors.forename: Kiran
authors.initials: K
authors.lastname: Nelamangala
authors.affiliation: Professor and Head, Department of Anaesthesia, Sri Devaraj Urs Medical College , Tamaka, Kolar, India .
authors.forename: Dinesh
authors.initials: D
authors.lastname: Krishnamurthy
keywords: Analgesia; Placebo; Regional anaesthesia