title: Breast malignant phyllodes tumor with rare pelvic metastases and long-term overall survival: A case report and literature review.
abstract: BACKGROUND
  Malignant phyllodes tumor (PT) is a rare fibro epithelial neoplasm of the breast, which is poor prognosis due to high risk of recurrence and distant metastasis.
  
  
  METHODS
  We report a case of malignant PT. It had recurred locally five times, and the sixth relapse was occurred 54 months after first diagnosis, presenting a huge pelvic mass (14 cm × 11 cm) by CT scan. Histopathological examination has demonstrated a metastatic phyllodes tumor. After postoperative chemotherapy treatment, a longer survival has been achieved, which is more than 72 months.
  
  
  RESULTS
  Our case report describes a breast PT with several local recurrences and a rare metastasis (pelvic cavity), but long-term overall survival was achieved after surgery and chemotherapy.
  
  
  CONCLUSIONS
  We conclude that trustworthy prognosticators that identify patients with excessive potential of aggressive clinical course should be explored. Moreover, proper treatment could prolong overall survival of metastatic PT patients.
authors.affiliation: Department of Surgical Oncology and Cancer Institute, Key Laboratory of Cancer Prevention & Intervention, National Ministry of Education, Provincial Key Laboratory of Molecular Biology in Medical Sciences, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou Department of Pathology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China Division of Hematopoietic Stem Cell and Leukemia Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA.
authors.forename: Jinlan
authors.initials: J
authors.lastname: Shan
authors.forename: Shizhen
authors.initials: S
authors.lastname: Zhang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.forename: Yanbiao
authors.initials: Y
authors.lastname: Fu
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.forename: Xiaochen
authors.initials: X
authors.lastname: Wang
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008408:Mastectomy / Q000379:methods; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D010386:Pelvic Neoplasms / Q000556:secondary* / Q000601:surgery; D010388:Pelvis / Q000473:pathology; D003557:Phyllodes Tumor / Q000556:secondary*; D000072078:Positron Emission Tomography Computed Tomography