title: Highly Enantioselective Direct Synthesis of Endocyclic Vicinal Diamines through Chiral Ru(diamine)-Catalyzed Hydrogenation of 2,2'-Bisquinoline Derivatives.
abstract: An asymmetric hydrogenation of 2,2'-bisquinoline and bisquinoxaline derivatives, catalyzed by chiral cationic ruthenium diamine complexes, was developed. A broad range of chiral endocyclic vicinal diamines were obtained in high yields with excellent diastereo- and enantioselectivity (up to 93:7 dl/meso and >99 % ee). These chiral diamines could be easily transformed into a new class of chiral N-heterocyclic carbenes (NHCs), which are important but difficult to access.
authors.affiliation: CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences, Beijing, 100190, P.R. China.|Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, 300072, P.R. China.
authors.forename: Wenpeng
authors.initials: W
authors.lastname: Ma
authors.affiliation: CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences, Beijing, 100190, P.R. China.|Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, 300072, P.R. China.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Zhang
authors.affiliation: CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences, Beijing, 100190, P.R. China.|Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, 300072, P.R. China.
authors.forename: Cong
authors.initials: C
authors.lastname: Xu
authors.affiliation: CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences, Beijing, 100190, P.R. China.|Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, 300072, P.R. China.
authors.forename: Fei
authors.initials: F
authors.lastname: Chen
authors.affiliation: CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences, Beijing, 100190, P.R. China.|Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, 300072, P.R. China.
authors.forename: Yan-Mei
authors.initials: YM
authors.lastname: He
authors.affiliation: CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences, Beijing, 100190, P.R. China. fanqh@iccas.ac.cn.|Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, 300072, P.R. China. fanqh@iccas.ac.cn.
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Fan
keywords: 2,2′-bisquinolines; asymmetric catalysis; homogeneous catalysis; hydrogenation; vicinal diamines