title: The effects of a multigrowth factor-containing cream on recovery after laser treatment: a double-blinded, randomized, split-face controlled study.
abstract: BACKGROUND
  Patients who receive laser treatments may experience transient erythema, edema, and crusts for several days. Although a variety of growth factor-containing creams for promoting recovery after laser treatment are available, evidence for their efficacy remains insufficient.
  
  
  OBJECTIVE
  We performed a randomized controlled split-face study to assess the effects of a multigrowth factor (MGF)-containing cream on patients recovering from laser treatment.
  
  
  METHODS
  Twenty patients underwent treatment using an ablative fractional laser and were randomized with respect to the side of the face treated with an MGF-containing cream or control cream. We measured post-treatment erythema and pigmentation using the erythema and melanin indices, respectively, and evaluated the total area of microcrusts with dermoscopy. Additionally, patient satisfaction levels and global improvement scores were assessed.
  
  
  RESULTS
  We found that the area of microcrusts was significantly smaller in the MGF-treated regions. Global improvement scores for post-treatment edema and wrinkles were also significantly higher for MGF cream-treated sides than for the control sides.
  
  
  CONCLUSIONS
  The MGF cream-treated regions showed a more rapid recovery from crusts and edema. Thus, the use of an MGF-containing cream after laser treatment can effectively reduce recovery time.
authors.affiliation: Department of Dermatology, Severance Hospital & Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Sungsik
authors.initials: S
authors.lastname: Shin
authors.affiliation: Department of Dermatology, Severance Hospital & Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Jung U
authors.initials: JU
authors.lastname: Shin
authors.affiliation: Department of Dermatology, Severance Hospital & Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Youngin
authors.initials: Y
authors.lastname: Lee
authors.affiliation: Department of Dermatology, Severance Hospital & Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Tae Gwang
authors.initials: TG
authors.lastname: Kwon
authors.affiliation: Department of Dermatology, Severance Hospital & Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Ju Hee
authors.initials: JH
authors.lastname: Lee
mesh_terms: D000328:Adult; D003357:Cosmetic Techniques / Q000009:adverse effects; D046169:Dermoscopy; D004311:Double-Blind Method; D004338:Drug Combinations; D004487:Edema / Q000188:drug therapy* / Q000209:etiology; D004815:Epidermal Growth Factor / Q000627:therapeutic use; D004890:Erythema / Q000188:drug therapy* / Q000209:etiology; D005145:Face; D005260:Female; D005346:Fibroblast Growth Factors / Q000627:therapeutic use; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use*; D054020:Lasers, Gas / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D010781:Photography; D010859:Pigmentation Disorders / Q000188:drug therapy* / Q000209:etiology; D010982:Platelet-Derived Growth Factor / Q000627:therapeutic use; D011446:Prospective Studies; D015595:Skin Aging; D063465:Skin Cream; D042461:Vascular Endothelial Growth Factor A / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects*; D055815:Young Adult
chemical_list: D004338:Drug Combinations; D036341:Intercellular Signaling Peptides and Proteins; D010982:Platelet-Derived Growth Factor; D042461:Vascular Endothelial Growth Factor A; D005346:Fibroblast Growth Factors; D004815:Epidermal Growth Factor
keywords: cosmeceutical; growth factor; laser treatment