title: Transition Metal Catalyzed Direct Amination of the Cage B(4)-H Bond in o-Carboranes: Synthesis of Tertiary, Secondary, and Primary o-Carboranyl Amines.
abstract: Transition metal catalyzed regioselective amination of the cage B(4)-H bond in o-carboranes has been achieved for the first time using O-benzoyl hydroxylamines or organic azides as the amination reagents, leading to the preparation of a series of tertiary and secondary carboranyl amines. Both amination reactions proceeded under mild conditions without the addition of any external oxidants. Hydrogenolysis of the resultant product 4-N(CH2Ph)2-o-carborane afforded the primary carboranyl amine, 4-amino-o-carborane, in quantitative yield.
authors.affiliation: Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The Chinese University of Hong Kong , Shatin, N. T., Hong Kong, China.
authors.forename: Hairong
authors.initials: H
authors.lastname: Lyu
authors.affiliation: Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The Chinese University of Hong Kong , Shatin, N. T., Hong Kong, China.
authors.forename: Yangjian
authors.initials: Y
authors.lastname: Quan
authors.affiliation: Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The Chinese University of Hong Kong , Shatin, N. T., Hong Kong, China.
authors.forename: Zuowei
authors.initials: Z
authors.lastname: Xie