title: Acupuncture for osteoporosis: a systematic review protocol.
abstract: Osteoporosis is a global high prevalence of chronic metabolic disease with serious disability-adjusted life years losing. Acupuncture is used to treat osteoporosis broadly in China and other countries although the evidence on effectiveness cannot give a certain answer. The aim of this systematic review protocol is to appraise the efficacy and safety of acupuncture for osteoporosis.
  
  
  
  A literature search of randomized controlled trials focusing on acupuncture for osteoporosis will be performed in the databases of Medline, Cochrane Library, Web of Science, EBASE, Springer, WHO International Clinical Trials Registry Platform (ICTRP), China National Knowledge Infrastructure (CNKI), Wan fang, Chinese Biomedical Literature Database (CBM), Chinese Scientific Journal Database (VIP), and other possible resources with a valid search strategy. Outcomes of pain, bone mineral density, fracture, mortality, improvement proportion, biochemical indicators, quality of life, adverse event, and other valid will be extracted and merged for quantitative analysis using Review Manager software (V.5.3.5) or descriptive analysis correspondingly.
  
  
  
  This is the first systematic review to estimate the effect of acupuncture on osteoporosis, and the result may provide evidence to clinical doctor.
  
  
  
  PROSPERO CRD42016037829.
authors.affiliation: School of Acupuncture-Tuina and Rehabilitation, Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan Province, China.
authors.forename: Taipin
authors.initials: T
authors.lastname: Guo
authors.affiliation: Xi'an Encephalopathy Hospital of Traditional Chinese Medicine, Xi'an, Shanxi Province, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Chen
authors.affiliation: Acupuncture Department, the First Affiliated Hospital, Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan Province, China.
authors.forename: Xiangnong
authors.initials: X
authors.lastname: Wu
authors.affiliation: School of Acupuncture-Tuina and Rehabilitation, Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan Province, China.
authors.forename: Exian
authors.initials: E
authors.lastname: Shan
authors.affiliation: School of Acupuncture-Tuina and Rehabilitation, Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan Province, China.
authors.forename: Yaju
authors.initials: Y
authors.lastname: Jin
authors.affiliation: School of Acupuncture-Tuina and Rehabilitation, Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan Province, China. taixiantao@163.com.
authors.forename: Xiantao
authors.initials: X
authors.lastname: Tai
authors.affiliation: School of Acupuncture-Tuina and Rehabilitation, Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan Province, China.
authors.forename: Zili
authors.initials: Z
authors.lastname: Liu
authors.affiliation: School of Acupuncture-Tuina and Rehabilitation, Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan Province, China.
authors.forename: Bowen
authors.initials: B
authors.lastname: Zhu
authors.affiliation: School of Acupuncture-Tuina and Rehabilitation, Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan Province, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Yuan
authors.affiliation: School of Acupuncture-Tuina and Rehabilitation, Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan Province, China. 0871czk@sina.com.
authors.forename: Zukun
authors.initials: Z
authors.lastname: Chen
mesh_terms: D015670:Acupuncture Therapy; D006801:Humans; D010024:Osteoporosis / Q000628:therapy*; D012107:Research Design; D000078202:Systematic Reviews as Topic