title: Acidic Co-Catalysts in Cationic Gold Catalysis.
abstract: A systematic study on the effects of Lewis or Brønsted acid co-catalysts in gold-catalyzed reactions was undertaken using representative reactions (O-, N-, and C-nucleophilic additions to alkynes). Through these reactions, it was demonstrated that an acidic co-catalyst can increase the catalyst turnover significantly, enabling practical reaction rates at competitive catalyst loadings (<1 mol %). Further investigation is currently underway to improve the understanding of the subtle principles underlying these experimental observations.
authors.affiliation: Departamento de Química Orgánica, Universidad de Valencia., 46100, Burjassot, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Barrio
authors.affiliation: Department of Chemistry, University of Louisville, Louisville, Kentucky, 40292, USA.
authors.forename: Manish
authors.initials: M
authors.lastname: Kumar
authors.affiliation: Department of Chemistry, University of Louisville, Louisville, Kentucky, 40292, USA.
authors.forename: Zhichao
authors.initials: Z
authors.lastname: Lu
authors.affiliation: Department of Chemistry, University of Louisville, Louisville, Kentucky, 40292, USA.
authors.forename: Junbin
authors.initials: J
authors.lastname: Han
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai, 201620, P. R. China. bo.xu@dhu.edu.cn.
authors.forename: Bo
authors.initials: B
authors.lastname: Xu
authors.affiliation: Department of Chemistry, University of Louisville, Louisville, Kentucky, 40292, USA. gb.hammond@louisville.edu.
authors.forename: Gerald B
authors.initials: GB
authors.lastname: Hammond
keywords: Lewis acid; catalyst decay; co-catalyst; gold catalysis; transition metal