title: Cardiac Relapse of Acute Myeloid Leukemia after Allogeneic Hematopoietic Stem Cell Transplantation.
abstract: Secondary or metastatic cardiac tumors are much more common than primary benign or malignant cardiac tumors. Any tumor can cause myocardial or pericardial metastasis, although isolated or combined tumor invasion of the pericardium is more common. Types of neoplasia with the highest rates of cardiac or pericardial involvement are melanoma, lung cancer, and breast and mediastinal carcinomas. Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. Initial treatment involves chemotherapy followed by consolidation treatment to reduce the risk of relapse. In high-risk patients, the treatment of choice for consolidation is hematopoietic stem cell transplantation (HSCT). Relapse of AML is the most common cause of HSCT failure. Extramedullary relapse is rare. The organs most frequently affected, called "sanctuaries," are the testes, ovaries, and central nervous system. We present a case with extramedullary relapse in the form of a solid cardiac mass.
authors.affiliation: Servicio de Cardiología, Hospital Universitario de La Candelaria, Carretera del Rosario No. 145, 38010 Santa Cruz de Tenerife, Spain.
authors.forename: María
authors.identifier: 0000-0003-1973-8577
authors.initials: M
authors.lastname: Facenda-Lorenzo
authors.affiliation: Hematology Service, University Hospital Nuestra Señora de La Candelaria, Santa Cruz de Tenerife, Tenerife, Canarias, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Sánchez-Quintana
authors.affiliation: Servicio de Cardiología, Hospital Universitario de La Candelaria, Carretera del Rosario No. 145, 38010 Santa Cruz de Tenerife, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Quijada-Fumero
authors.affiliation: Servicio de Cardiología, Hospital Universitario de La Candelaria, Carretera del Rosario No. 145, 38010 Santa Cruz de Tenerife, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Laynez-Carnicero
authors.affiliation: Hematology Service, University Hospital Nuestra Señora de La Candelaria, Santa Cruz de Tenerife, Tenerife, Canarias, Spain.
authors.forename: Joaquín
authors.initials: J
authors.lastname: Breña-Atienza
authors.affiliation: Servicio de Cardiología, Hospital Universitario de La Candelaria, Carretera del Rosario No. 145, 38010 Santa Cruz de Tenerife, Spain.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Poncela-Mireles
authors.affiliation: Radiology Service, University Hospital Nuestra Señora de La Candelaria, Santa Cruz de Tenerife, Tenerife, Canarias, Spain.
authors.forename: Juan M
authors.initials: JM
authors.lastname: Llanos-Gómez
authors.affiliation: Hematology Service, University Hospital Nuestra Señora de La Candelaria, Santa Cruz de Tenerife, Tenerife, Canarias, Spain.
authors.forename: Ana I
authors.initials: AI
authors.lastname: Cabello-Rodríguez
authors.affiliation: Servicio de Cardiología, Hospital Universitario de La Candelaria, Carretera del Rosario No. 145, 38010 Santa Cruz de Tenerife, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Ramos-López