title: An experimental study: evaluating the tissue structure of penis with 2D-ShearWave™ Elastography.
abstract: The aim of this study was to investigate the feasibility of two-dimensional-ShearWave™ Elastography (2D-SWE) on evaluating the change of tissue structure of penis. Twenty healthy male Sprague Dawley rats were divided into penis-developed group (PDG, 52 weeks) and penis-underdeveloped group (PUDG, 5 weeks). The ultrafast ultrasound device-Aixplorer® (SuperSonic Imagine) was used for 2D-SWE imaging of the penis, the measurement index was shear wave stiffness (SWS, kPa). All rat penises were cut off immediately after ultrasonic examination. After paraffin embedding, slicing and hematoxylin-eosin staining, the tissue structure of the penis was observed under light microscope. SWS of all rat penises were measured successfully. The results showed that SWS of PDG was significantly lower than PUDG (P=0.008). At the same time, the pathological results found that there were significant differences in the tissue structures (sinusoids, smooth muscle cells and fibrocytes) of the penises between the two groups. These results suggest that there are significant differences in SWS between different tissue structures of penis. 2D-SWE is expected to be used on the etiological diagnosis of erectile dysfunction by serving as a new noninvasive method of evaluating the change of tissue structure of penis.
authors.affiliation: Department of Medical Ultrasound, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
authors.forename: X-H
authors.initials: XH
authors.lastname: Qiao
authors.affiliation: Department of Medical Ultrasound, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
authors.forename: J-J
authors.initials: JJ
authors.lastname: Zhang
authors.affiliation: Department of Medical Ultrasound, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
authors.forename: F
authors.initials: F
authors.lastname: Gao
authors.affiliation: Department of Medical Ultrasound, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
authors.forename: F
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Medical Ultrasound, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Medical Ultrasound, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
authors.forename: L-X
authors.initials: LX
authors.lastname: Xing
authors.affiliation: Department of Medical Ultrasound, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
authors.forename: L-F
authors.initials: LF
authors.lastname: Du
authors.affiliation: Department of Medical Ultrasound, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
authors.forename: J-F
authors.initials: JF
authors.lastname: Xing
mesh_terms: D000818:Animals; D054459:Elasticity Imaging Techniques / Q000379:methods*; D008297:Male; D010413:Penis / Q000000981:diagnostic imaging* / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley