title: Long-Circulating Au-TiO2Nanocomposite as a Sonosensitizer for ROS-Mediated Eradication of Cancer.
abstract: Although sonodynamic therapy (SDT) has emerged as a potential alternative to conventional photodynamic therapy, the low quantum yield of the sonosensitizer such as TiO2nanoparticles (NPs) is still a major concern. Here, we have developed hydrophilized Au-TiO2nanocomposites (HAu-TiO2NCs) as sonosensitizers for improved SDT. The physicochemical properties of HAu-TiO2NCs were thoroughly studied and compared with their counterparts without gold deposition. Upon exposure of HAu-TiO2NCs to ultrasound, a large quantity of reactive oxygen species (ROS) were generated, leading to complete suppression of tumor growth after their systemic administration in vivo. Overall, it was evident that the composites of gold with TiO2NPs significantly augmented the levels of ROS generation, implying their potential as SDT agents for cancer therapy.
authors.affiliation: School of Chemical Engineering, College of Engineering, Sungkyunkwan University , Suwon 16419, Republic of Korea.
authors.forename: V G
authors.initials: VG
authors.lastname: Deepagan
authors.affiliation: School of Chemical Engineering, College of Engineering, Sungkyunkwan University , Suwon 16419, Republic of Korea.|Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology , Seoul 02792, Republic of Korea.
authors.forename: Dong Gil
authors.initials: DG
authors.lastname: You
authors.affiliation: Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology , Seoul 02792, Republic of Korea.|Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University , Seoul 06351, Republic of Korea.
authors.forename: Wooram
authors.initials: W
authors.lastname: Um
authors.affiliation: Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University , Seoul 06351, Republic of Korea.
authors.forename: Hyewon
authors.initials: H
authors.lastname: Ko
authors.affiliation: School of Chemical Engineering, College of Engineering, Sungkyunkwan University , Suwon 16419, Republic of Korea.
authors.forename: Seunglee
authors.initials: S
authors.lastname: Kwon
authors.affiliation: School of Chemical Engineering, College of Engineering, Sungkyunkwan University , Suwon 16419, Republic of Korea.
authors.forename: Ki Young
authors.initials: KY
authors.lastname: Choi
authors.affiliation: School of Chemical Engineering, College of Engineering, Sungkyunkwan University , Suwon 16419, Republic of Korea.
authors.forename: Gi-Ra
authors.initials: GR
authors.lastname: Yi
authors.affiliation: School of Chemical Engineering, College of Engineering, Sungkyunkwan University , Suwon 16419, Republic of Korea.
authors.forename: Jun Young
authors.initials: JY
authors.lastname: Lee
authors.affiliation: School of Chemical Engineering, College of Engineering, Sungkyunkwan University , Suwon 16419, Republic of Korea.
authors.forename: Doo Sung
authors.initials: DS
authors.lastname: Lee
authors.affiliation: Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology , Seoul 02792, Republic of Korea.
authors.forename: Kwangmeyung
authors.initials: K
authors.lastname: Kim
authors.affiliation: Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology , Seoul 02792, Republic of Korea.
authors.forename: Ick Chan
authors.initials: IC
authors.lastname: Kwon
authors.affiliation: School of Chemical Engineering, College of Engineering, Sungkyunkwan University , Suwon 16419, Republic of Korea.|Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University , Seoul 06351, Republic of Korea.
authors.forename: Jae Hyung
authors.initials: JH
authors.lastname: Park
keywords: Au-TiO2 nanocomposite; ROS; enhanced sonodynamic therapy; prolonged circulation; ultrasound