title: Endometriosis and Glanzmanns thrombasthenia.
abstract: Glanzmanns thrombasthenia (GT) is a rare bleeding syndrome characterized by deficiency or defect of platelet aggregation complex. The pathogenesis of endometriosis is controversial but the strongest evidence leans towards retrograde menstruation. GT probably predisposes to endometriosis. The management of women affected by this disease can be difficult due to the risk of bleeding complications, especially during surgical treatment. We describe the cases of three sisters affected by endometriosis and GT, referred to our Department, who received different therapeutic management.
authors.affiliation: Department of Gynecology, Obstetrics and Urology, Sapienza, University of Rome, Policlinico Umberto I, Rome, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Imperiale
authors.affiliation: Department of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Policlinico Umberto I, Rome, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Manganaro
authors.affiliation: Department of Gynecology, Obstetrics and Urology, Sapienza, University of Rome, Policlinico Umberto I, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Ticino
authors.affiliation: Department of Gynecology, Obstetrics and Urology, Sapienza, University of Rome, Policlinico Umberto I, Rome, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Piacenti
authors.affiliation: Department of Molecular Medicine, Sapienza University of Rome, Policlinico Umberto I, Rome, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Anastasi
authors.affiliation: Department of Gynecology, Obstetrics and Urology, Sapienza, University of Rome, Policlinico Umberto I, Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Resta
authors.affiliation: Department of Gynecology, Obstetrics and Urology, Sapienza, University of Rome, Policlinico Umberto I, Rome, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Benedetti Panici
authors.affiliation: Department of Gynecology, Obstetrics and Urology, Sapienza, University of Rome, Policlinico Umberto I, Rome, Italy.
authors.forename: M G
authors.initials: MG
authors.lastname: Porpora
mesh_terms: D000328:Adult; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects / Q000627:therapeutic use; D004198:Disease Susceptibility; D004200:Diseases in Twins; D004715:Endometriosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D015942:Factor VIIa / Q000627:therapeutic use; D005260:Female; D006409:Hematometra / Q000209:etiology; D006474:Hemorrhagic Disorders / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D007436:Intrauterine Devices, Medicated; D016912:Levonorgestrel / Q000627:therapeutic use; D017258:Medroxyprogesterone Acetate / Q000627:therapeutic use; D008595:Menorrhagia / Q000209:etiology; D010049:Ovarian Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology / Q000601:surgery; D019990:Perioperative Care; D011994:Recombinant Proteins / Q000627:therapeutic use; D012002:Rectal Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology; D013915:Thrombasthenia / Q000150:complications* / Q000235:genetics; D014148:Tranexamic Acid / Q000627:therapeutic use; D017329:Triptorelin Pamoate / Q000627:therapeutic use; D014623:Vaginal Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology
chemical_list: D003278:Contraceptives, Oral, Hormonal; D011994:Recombinant Proteins; D017329:Triptorelin Pamoate; D016912:Levonorgestrel; D014148:Tranexamic Acid; C103587:recombinant FVIIa; D017258:Medroxyprogesterone Acetate; D015942:Factor VIIa