title: Unusual presentation of Erdheim-Chester disease in a child with acute lymphoblastic leukemia.
abstract: Erdheim-Chester disease (ECD) is an uncommon, non-familial, non-Langerhans cell histiocytosis, which involves skeletal system and soft tissue usually in middle aged and elderly patients. The characteristic radiologic features include bilateral, symmetric cortical osteosclerosis of the diaphyseal and metaphyseal parts of the long bones, or bilateral symmetrically abnormal intense (99m)Technetium labelling of the metaphyseal-diaphyseal region of the long bones, and computed tomography scan findings of "coated aorta" or "hairy kidneys". ECD in childhood with osteolytic lesion is extremely rare. We describe an unusual case with an expansile lytic bone lesion at presentation in a case of acute lymphoblastic leukemia.
authors.affiliation: Archana George Vallonthaiel, Asit Ranjan Mridha, Mehar Chand Sharma, Department of Pathology, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Archana George
authors.initials: AG
authors.lastname: Vallonthaiel
authors.affiliation: Archana George Vallonthaiel, Asit Ranjan Mridha, Mehar Chand Sharma, Department of Pathology, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Asit Ranjan
authors.initials: AR
authors.lastname: Mridha
authors.affiliation: Archana George Vallonthaiel, Asit Ranjan Mridha, Mehar Chand Sharma, Department of Pathology, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Shivanand
authors.initials: S
authors.lastname: Gamanagatti
authors.affiliation: Archana George Vallonthaiel, Asit Ranjan Mridha, Mehar Chand Sharma, Department of Pathology, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Manisha
authors.initials: M
authors.lastname: Jana
authors.affiliation: Archana George Vallonthaiel, Asit Ranjan Mridha, Mehar Chand Sharma, Department of Pathology, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Mehar Chand
authors.initials: MC
authors.lastname: Sharma
authors.affiliation: Archana George Vallonthaiel, Asit Ranjan Mridha, Mehar Chand Sharma, Department of Pathology, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Shah Alam
authors.initials: SA
authors.lastname: Khan
authors.affiliation: Archana George Vallonthaiel, Asit Ranjan Mridha, Mehar Chand Sharma, Department of Pathology, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Sameer
authors.initials: S
authors.lastname: Bakhshi
keywords: Acute lymphoblastic leukemia; Bone; Erdheim-Chester disease; Osteolytic lesion