title: Paclitaxel loaded magnetic nanocomposites with folate modified chitosan/carboxymethyl surface; a vehicle for imaging and targeted drug delivery.
abstract: In this study, Paclitaxel (PTX) containing, bovine serum albumin (BSA) nanoparticles were fabricated via a simple approach. Folic acid (FA) was conjugated to chitosan (CS)/carboxymethyl cellulose (CMC) through an esterification reaction to produce BSA-CS-FA or BSA-CMC-FA conjugates. NiFe2O4noncore (NFs) and PTX were loaded through a heat treatment and by a diffusion process. NFs-BSA-CS and NFs-BSA-CMC-FA with size of about 80nm, showed superior transversal R2relaxation rate of 349 (mM)-1s-1along with folate receptor-targeted and magnetically directed functions. NFs-BSA-CS-FA or NFs-BSA-CS-FA were found stable and biocompatible. Application of an external magnetic field effectively enhanced the PTX release from PTX-NFs-BSA-CS-FA or PTX-NFs-BSA-CS-FA and hence tumor inhibition rate. This study validate that NFs-BSA-CS-FA or NFs-BSA-CMC-FA and PTX-NFs-BSA-CS-FA or PTX-NFs-BSA-CS-FA are suitable systems for tumor diagnosis and therapy.
authors.affiliation: Department of Physics, The Islamia University of Bahawalpur, Pakistan; Nanosciences and Technology Department (NSTD), National Centre for Physics (NCP), Islamabad, Pakistan; Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan. Electronic address: shaziaphy@gmail.com.
authors.forename: Shazia
authors.initials: S
authors.lastname: Bano
authors.affiliation: Department of Physics, The Islamia University of Bahawalpur, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Afzal
authors.affiliation: Radiology (diagnostic), Quaid- e- Azam Medical College B.V.H, Pakistan.
authors.forename: Mustansar Mahmood
authors.initials: MM
authors.lastname: Waraich
authors.affiliation: National Institute of Vacuum Science & Technology (NINVAST), Pakistan.
authors.forename: Khalid
authors.initials: K
authors.lastname: Alamgir
authors.affiliation: Nanosciences and Technology Department (NSTD), National Centre for Physics (NCP), Islamabad, Pakistan. Electronic address: seegasami01@yahoo.com.
authors.forename: Samina
authors.initials: S
authors.lastname: Nazir
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000737:chemistry / Q000627:therapeutic use; D016503:Drug Delivery Systems; D065546:Drug Liberation; D004912:Erythrocytes / Q000187:drug effects; D005290:Ferric Compounds / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D005492:Folic Acid / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D006461:Hemolysis; D006801:Humans; D061986:MCF-7 Cells; D060328:Magnetic Phenomena; D053761:Nanocomposites / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy; D009532:Nickel / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D017239:Paclitaxel / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D012710:Serum Albumin, Bovine / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005290:Ferric Compounds; C514968:carboxymethyl-chitosan; C550717:nickel ferrite; D012710:Serum Albumin, Bovine; D009532:Nickel; D048271:Chitosan; D005492:Folic Acid; D017239:Paclitaxel
keywords: Biopolymers; Drug delivery system; Folate conjugation; Magnetic drug release; Magnetic resonance imaging