title: What we need to know about renal nerve ablation for treatment of hypertension and other states of sympathetic overactivity.
abstract: Renal nerves are key players in the regulation of kidney function and blood pressure control. Targeting the neurogenic mechanisms underlying hypertension and cardiac and renal disease has been attempted by means of surgical and pharmacologic approaches and most recently by catheter-based interventions aimed at disrupting renal sympathetic nerve traffic. The recent developments in the area and the relevant questions that need to be addressed to advance the field further are briefly reviewed in this article.
authors.affiliation: School of Medicine and Pharmacology-Royal Perth Hospital Unit, The University of Western Australia, Perth, Western Australia, Australia; markus.schlaich@uwa.edu.au.|Neurovascular Hypertension and Kidney Disease Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia; and.|Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.
authors.forename: Markus P
authors.initials: MP
authors.lastname: Schlaich
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology / Q000628:therapy*; D007668:Kidney / Q000294:innervation* / Q000503:physiopathology; D013562:Sympathectomy / Q000379:methods*; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D016896:Treatment Outcome
keywords: blood pressure; cardiovascular disease; renal denervation; resistant hypertension; sympathetic overactivity