title: Increased Plasma Dipeptidyl Peptidase-4 Activities in Patients with Coronary Artery Disease.
abstract: Dipeptidyl peptidase-4 (DPP4) is one of the most potent mammalian serine proteases participated in the pathogenesis of subclinical atherosclerosis. Here we investigated whether the plasma soluble form of DPP4 is associated with the prevalence of coronary artery disease (CAD) with and without diabetes mellitus (DM). A cross-sectional study was conducted of 496 aged 26-81 years with (n = 362) and without (n = 134) CAD. Plasma DPP4 activity, high sensitive C-reactive protein (hs-CRP), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein levels were measured. The coronary atherosclerotic plaques were evaluated by coronary angiography. The CAD patients with (n = 84) and without (n = 278) DM had significantly higher DPP4 levels (11.8 ± 3.1 vs. 6.9 ± 3.5 ng/mL, P<0.01) than the nonCAD subjects. The acute coronary syndrome patients (n = 299) had elevated DPP4 levels than those with stable angina patients (n = 83). CAD patients even without DM had increased plasma DPP4 activities as compared with nonCAD subjects (10.9 ± 4.9 vs. 6.4 ± 3.1, ng/L, P< 0.01). A linear regression analysis revealed that overall, the DPP4 levels were positively associated with LCL-C and hs-CRP levels as well as syntax scores. A multiple logistic regression analysis demonstrated that plasma DPP4 activity was independent predictor of CAD (odds ratio, 1.56; 95% CI, 1.19-1.73; P<0.01). Our study shows that increased DPP4 activity levels are associated with the presence of CAD and that the plasma DPP4 level serves as a novel biomarker for CAD even without DM.
authors.affiliation: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin P.R., China.
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin P.R., China.
authors.forename: Yuzi
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin P.R., China.
authors.forename: Lan
authors.initials: L
authors.lastname: Cui
authors.affiliation: Department of Physiology, Yanbian University Medical College, Yanji, China.
authors.forename: Haiying
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin P.R., China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Central Laboratory, Yanbian University Hospital, Yanji, China.
authors.forename: Chunzi
authors.initials: C
authors.lastname: Jin
authors.affiliation: Department of Angiography Center, Yanbian University Hospital, Yanji, China.
authors.forename: Dehao
authors.initials: D
authors.lastname: Jin
authors.affiliation: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin P.R., China.
authors.forename: Guangxian
authors.initials: G
authors.lastname: Zhao
authors.affiliation: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin P.R., China.
authors.forename: Jiyong
authors.initials: J
authors.lastname: Jin
authors.affiliation: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin P.R., China.
authors.forename: Rui
authors.initials: R
authors.lastname: Sun
authors.affiliation: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin P.R., China.
authors.forename: Limei
authors.initials: L
authors.lastname: Piao
authors.affiliation: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin P.R., China.
authors.forename: Wenhu
authors.initials: W
authors.lastname: Xu
authors.affiliation: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin P.R., China.
authors.forename: Chenghu
authors.initials: C
authors.lastname: Fang
authors.affiliation: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin P.R., China.
authors.forename: Yanna
authors.initials: Y
authors.lastname: Lei
authors.affiliation: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin P.R., China.
authors.forename: Kuichang
authors.initials: K
authors.lastname: Yuan
authors.affiliation: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin P.R., China.
authors.forename: Chunhua
authors.initials: C
authors.lastname: Xuan
authors.affiliation: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin P.R., China.
authors.forename: Dazi
authors.initials: D
authors.lastname: Ding
authors.affiliation: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin P.R., China.|Department of Internal Medicine, Kyung Hee University, Seoul, South Korea.
authors.forename: Xianwu
authors.identifier: http://orcid.org/0000-0002-9758-0632
authors.initials: X
authors.lastname: Cheng