title: Treatment-related myelodysplastic syndrome (t-MDS)/acute myeloid leukemia (AML) in children with cancer: A single-center experience.
abstract: Treatment-related myelodysplastic syndrome (t-MDS)/acute myeloid leukemia (AML) is a devastating early or late complication of treatment for childhood cancer related with a significant morbidity and mortality. We retrospectively studied survivors of childhood cancer. Overall, 287 patients were recorded in the databases and we identified three (1.04%) with t-MDS. The primary cancer diagnoses were Langerhans cell histiocytosis (one patient) and acute lymphoblastic leukemia (ALL; two patients). The mean age of patients was 12.1 years. All patients had received systemic antifungal treatment for invasive pulmonary aspergillosis successfully treated with voriconazole and liposomal amphotericin B before diagnosis of t-MDS. Two patients (66%) remain alive after a median follow-up period of 3.5 years.
authors.affiliation: 2nd Pediatric Department, Aristotle University of Thessaloniki, AHEPA Hospital, Greece atragian@auth.gr.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Tragiannidis
authors.affiliation: 2nd Pediatric Department, Aristotle University of Thessaloniki, AHEPA Hospital, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Gombakis
authors.affiliation: 2nd Pediatric Department, Aristotle University of Thessaloniki, AHEPA Hospital, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Papageorgiou
authors.affiliation: 2nd Pediatric Department, Aristotle University of Thessaloniki, AHEPA Hospital, Greece.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Hatzipantelis
authors.affiliation: 2nd Pediatric Department, Aristotle University of Thessaloniki, AHEPA Hospital, Greece.
authors.forename: Theodotis
authors.initials: T
authors.lastname: Papageorgiou
authors.affiliation: 2nd Pediatric Department, Aristotle University of Thessaloniki, AHEPA Hospital, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Hatzistilianou
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008297:Male; D009190:Myelodysplastic Syndromes / Q000139:chemically induced*; D016609:Neoplasms, Second Primary / Q000188:drug therapy*; D012189:Retrospective Studies; D065819:Voriconazole / Q000008:administration & dosage
chemical_list: C068538:liposomal amphotericin B; D000666:Amphotericin B; D065819:Voriconazole
keywords: Childhood; treatment-related myelodysplastic syndromes