title: Effect of Fibrin Glue on the Incidence of Surgical Complications After Living-Related-Donor Kidney Transplantation: Results of a Randomized Clinical Trial.
abstract: BACKGROUND The incidence of surgical complications after kidney transplantation ranges from 10-25%. The purpose of this study was to evaluate if the application of fibrin glue as a preventive agent reduces surgical morbidity after a living-related-donor kidney transplantation. MATERIAL AND METHODS A controlled clinical trial involving 78 recipients randomly assigned to receive fibrin glue and 79 in the control group without the application of fibrin glue. Patients were followed for six months after surgery. RESULTS The average ages were 24.8±9.4 and 27.4±11.3 years in the control and study groups, respectively (p=0.11). Individual morbidities, such as urologic, lymphatic, vascular, and wound complications, were not statistically different between groups; however, the total number of surgical complications observed were in five patients in the study group and 16 patients in the control group. This difference was statistically significant (p<0.01, relative risk 0.44, 95% CI 0.20-0.97). There was no mortality or adverse reaction to fibrin glue. One kidney graft was lost because of uncontrollable bleeding secondary to tearing of the renal capsule. The incidence of early medical complications was similar between groups. CONCLUSIONS Applications of the biological adhesive reduced the incidence of surgical complications.
authors.affiliation: Biomedical Research Unit 02, Specialties Hospital, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: Clotilde
authors.initials: C
authors.lastname: Fuentes-Orozco
authors.affiliation: Biomedical Research Unit 02, Specialties Hospital, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: Salvador
authors.initials: S
authors.lastname: González-Mercado
authors.affiliation: Department of Urology and Transplant, Specialties Hospital, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: Joel Mario
authors.initials: JM
authors.lastname: Sandoval-Sandoval
authors.affiliation: Department of Vascular and Solid Organ Transplant, Specialties Hospital, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: Carlos
authors.initials: C
authors.lastname: Valdespino-Mejía
authors.affiliation: Department of Urology and Transplant, Specialties Hospital, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: Eduardo
authors.initials: E
authors.lastname: González-González
authors.affiliation: Department of Vascular and Solid Organ Transplant, Specialties Hospital, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: Juan Narciso
authors.initials: JN
authors.lastname: Ramírez-Robles
authors.affiliation: Department of Nephrology, Specialties Hospital, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: Benjamín
authors.initials: B
authors.lastname: Gómez-Navarro
authors.affiliation: Department of Anesthesiology, Specialties Hospital, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: Blanca Estela
authors.initials: BE
authors.lastname: Dávalos-Delgadillo
authors.affiliation: Department of Anesthesiology, Specialties Hospital, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: Leticia
authors.initials: L
authors.lastname: Marquez-Leaño
authors.affiliation: Biomedical Research Unit 02, Specialties Hospital, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: Mariana
authors.initials: M
authors.lastname: Chávez-Tostado
authors.affiliation: Biomedical Research Unit 02, Specialties Hospital, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: Anais
authors.initials: A
authors.lastname: Ramírez-Arce
authors.affiliation: Biomedical Research Unit 02, Specialties Hospital, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Andalón-Dueñas
authors.affiliation: Biomedical Research Unit 02, Specialties Hospital, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: Arturo
authors.initials: A
authors.lastname: Espinosa-Partida
authors.affiliation: Biomedical Research Unit 02, Specialties Hospital, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: Michel Dassaejv
authors.initials: MD
authors.lastname: Macías-Amezcua
authors.affiliation: Biomedical Research Unit 02, Specialties Hospital, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: Alejandro
authors.initials: A
authors.lastname: González-Ojeda
keywords: Fibrin Tissue Adhesive; Kidney Transplantation; Morbidity