title: Uterus human leucocyte antigen expression in the perspective of transplantation.
abstract: OBJECTIVE
  To describe class I and II human leucocyte antigen (HLA) expression using different uterine tissues in the perspective of uterus transplantation.
  
  
  METHODS
  Human uterine tissues were obtained from 12 women who had undergone hysterectomy for the treatment of benign disease. HLA class I and HLA-antigen D related (DR) expression were assessed via immunochemistry. HLA class I expression in the uterus was compared with expression in other organs and tissues, including kidney and myocardium samples.
  
  
  RESULTS
  HLA class I expression was strong in the endometrial glands and mild in the myometrium. Staining of endometrial glands was similar to glomerular staining in the kidney. The myometrium seems to express HLA class I similarly to hepatocytes and myocardial cells. HLA class I expression in the uterus did not differ in younger or post-menopausal women. HLA-DR was expressed in the endometrial glands, but not in the myometrium. A lack of HLA-DR expression seemed to be correlated with cell proliferation.
  
  
  CONCLUSIONS
  HLA expression in the endometrium and myometrium is different. The endometrium should be the major target of alloreactive response. As for other transplanted organs, assessment of HLA unacceptable antigens and multiple immunosuppressive treatments is necessary in uterus transplantation.
authors.affiliation: Obstetrics and Gynecology Department, CHU Limoges, France.|UMR-850 INSERM, University of Medicine, Limoges, France.
authors.forename: Tristan
authors.initials: T
authors.lastname: Gauthier
authors.affiliation: Laboratory of Immunology and Immunogenetics, CHU Limoges, France.
authors.forename: Matthieu
authors.initials: M
authors.lastname: Filloux
authors.affiliation: Anatomopathology Department, CHU Limoges, France.
authors.forename: Angelique
authors.initials: A
authors.lastname: Guillaudeau
authors.affiliation: Nephrology, Dialysis, Transplantation CHU Limoges, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Essig
authors.affiliation: University of Limoges, EA 3842 Homéostasie Cellulaire et Pathologies, University of Medicine, Limoges, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Bibes
authors.affiliation: Laboratory of Immunology and Immunogenetics, CHU Limoges, France.
authors.forename: Adam Fodil
authors.initials: AF
authors.lastname: Pacha
authors.affiliation: Obstetrics and Gynecology Department, CHU Limoges, France.|UMR-850 INSERM, University of Medicine, Limoges, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Piver
authors.affiliation: Obstetrics and Gynecology Department, CHU Limoges, France.|UMR-850 INSERM, University of Medicine, Limoges, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Aubard
authors.affiliation: UMR-850 INSERM, University of Medicine, Limoges, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Marquet
authors.affiliation: Laboratory of Immunology and Immunogenetics, CHU Limoges, France.
authors.forename: Mireille
authors.initials: M
authors.lastname: Drouet
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006680:HLA Antigens / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008593:Menopause; D008875:Middle Aged; D054792:Muscle, Striated / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009215:Myometrium / Q000378:metabolism; D014599:Uterus / Q000378:metabolism* / Q000637:transplantation*
chemical_list: D006680:HLA Antigens
keywords: HLA; fertility; immunogenicity; transplantation; uterus