title: Molecular epidemiology of the enteroviruses associated with hand, foot and mouth disease/herpangina in Dongguan, China, 2015.
abstract: Enteroviruses (EVs) are the etiological agents involved in most cases of hand, foot and mouth disease (HFMD) and herpangina (HA). Information on the epidemiology profiles of EVs in China is very limited, as the present surveillance system of China focuses on CAV16 and EV71, and no published data are available in Dongguan. The aim of this study is to determine the prevalence of EVs among patients with HFMD and HA in Dongguan, China, during 2015. A total of 271 clinical stool specimens that were clinically determined to be positive for enteroviruses were genotyped by semi-nested polymerase chain reaction (PCR) for the VP1 genes of EVs. The results showed that a total of 14 enterovirus genotypes were identified among HFMD and HA patients in this study. CVA6 was the most common genotype for HFMD, and CVA2 accounted for the majority of HA cases in this study. Sequence and phylogenetic analysis showed that all of the CVA6 and CVA2 strains identified in our study displayed a close genetic relationship to strains identified in other cities in China. This study also demonstrates that there are associations between particular causative enterovirus genotypes and some clinical symptoms, which may provide useful information for improving case prevention, diagnosis and treatment of HFMD and HA.
authors.affiliation: Department of Pediatric Infectious Diseases, Children's Hospital of Dongguan, Dongguan, Guangdong, China.|Department of Medical and Molecular Genetics, Dongguan Institute of Pediatrics, Dongguan, Guangdong, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Peng
authors.affiliation: Department of Pediatric Infectious Diseases, Children's Hospital of Dongguan, Dongguan, Guangdong, China.|Department of Medical and Molecular Genetics, Dongguan Institute of Pediatrics, Dongguan, Guangdong, China.|Guangdong Medical University, Dongguan, Guangdong, China.
authors.forename: Mingyu
authors.initials: M
authors.lastname: Xie
authors.affiliation: Department of Pediatric Infectious Diseases, Children's Hospital of Dongguan, Dongguan, Guangdong, China.|Department of Medical and Molecular Genetics, Dongguan Institute of Pediatrics, Dongguan, Guangdong, China.
authors.forename: Yinghong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Pediatric Infectious Diseases, Children's Hospital of Dongguan, Dongguan, Guangdong, China.|Department of Medical and Molecular Genetics, Dongguan Institute of Pediatrics, Dongguan, Guangdong, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Pediatric Infectious Diseases, Children's Hospital of Dongguan, Dongguan, Guangdong, China.|Department of Medical and Molecular Genetics, Dongguan Institute of Pediatrics, Dongguan, Guangdong, China.
authors.forename: Wenrui
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Pediatric Infectious Diseases, Children's Hospital of Dongguan, Dongguan, Guangdong, China.|Department of Medical and Molecular Genetics, Dongguan Institute of Pediatrics, Dongguan, Guangdong, China.
authors.forename: Siping
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Pediatric Infectious Diseases, Children's Hospital of Dongguan, Dongguan, Guangdong, China.|Department of Medical and Molecular Genetics, Dongguan Institute of Pediatrics, Dongguan, Guangdong, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Department of Pediatric Infectious Diseases, Children's Hospital of Dongguan, Dongguan, Guangdong, China. lxm020@126.com.|Department of Medical and Molecular Genetics, Dongguan Institute of Pediatrics, Dongguan, Guangdong, China. lxm020@126.com.
authors.forename: Xiaomei
authors.identifier: http://orcid.org/0000-0002-1647-0547
authors.initials: X
authors.lastname: Lu
authors.affiliation: Department of Pediatric Infectious Diseases, Children's Hospital of Dongguan, Dongguan, Guangdong, China. zbomao@163.com.|Department of Medical and Molecular Genetics, Dongguan Institute of Pediatrics, Dongguan, Guangdong, China. zbomao@163.com.|Guangdong Medical University, Dongguan, Guangdong, China. zbomao@163.com.
authors.forename: Baimao
authors.initials: B
authors.lastname: Zhong
mesh_terms: D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D016000:Cluster Analysis; D004770:Enterovirus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D005243:Feces / Q000821:virology; D005260:Female; D005838:Genotype; D060005:Genotyping Techniques; D006232:Hand, Foot and Mouth Disease / Q000453:epidemiology* / Q000473:pathology / Q000821:virology*; D006557:Herpangina / Q000453:epidemiology* / Q000473:pathology / Q000821:virology*; D006801:Humans; D007223:Infant; D008297:Male; D017720:Molecular Epidemiology; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D015995:Prevalence; D017422:Sequence Analysis, DNA; D015678:Viral Structural Proteins / Q000235:genetics
chemical_list: D015678:Viral Structural Proteins