title: Good quantification practices of flavours and fragrances by mass spectrometry.
abstract: Over the past 15 years, chromatographic techniques with mass spectrometric detection have been increasingly used to monitor the rapidly expanded list of regulated flavour and fragrance ingredients. This trend entails a need for good quantification practices suitable for complex media, especially for multi-analytes. In this article, we present experimental precautions needed to perform the analyses and ways to process the data according to the most recent approaches. This notably includes the identification of analytes during their quantification and method validation, when applied to real matrices, based on accuracy profiles. A brief survey of application studies based on such practices is given.This article is part of the themed issue 'Quantitative mass spectrometry'.
authors.affiliation: Firmenich SA, Corporate R&D Division, Route des Jeunes 1, CH-1211 Geneva 8, Switzerland frederic.begnaud@firmenich.com.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Begnaud
authors.affiliation: Firmenich SA, Corporate R&D Division, Route des Jeunes 1, CH-1211 Geneva 8, Switzerland firm.alc@sfr.fr.
authors.forename: Alain
authors.identifier: http://orcid.org/0000-0002-1665-0521
authors.initials: A
authors.lastname: Chaintreau
keywords: good practices; identification points; mass spectrometry; multi-analyte; quantification; validation