title: Improvement in visualization of carotid artery uniformity using silent magnetic resonance angiography.
abstract: Three-dimensional time-of-flight magnetic resonance angiography (TOF MRA) has been widely used in clinics. TOF MRA can cause dephasing artifacts, which lead to an intraluminal signal decrease. Silent MRA is a novel imaging technique that uses arterial spin labeling to achieve an ultrashort echo time (uTE), which is expected to decrease these effects and allow for accurate assessment of the flow in blood vessels. This study quantified the accuracy of Silent MRA images for visualizing the turbulent flow in flow-phantom and in vivo studies. The vessel contrast and coefficients of variation (CVs) for Silent MRA and TOF MRA were compared using normal and stenosis phantoms. Then, we performed both types of MRA on seven healthy volunteers. In the phantom study, although the contrast in the TOF MRA images was low distal to the stenosis region and at a high flow velocity, the contrast in the Silent MRA images did not change under these conditions. Furthermore, the mean CV for Silent MRA was smaller than that for TOF MRA under stenosis conditions. In the in vivo study, the mean contrast and vessel uniformity were significantly higher for Silent MRA than for TOF MRA. Although Silent MRA has limited spatial resolution and requires additional imaging time, this method may have the potential to improve the image quality of the carotid artery.
authors.affiliation: Department of Medical Imaging, Faculty of Life Sciences, Kumamoto University, 4-24-1 Kuhonji, Chuo-ku, Kumamoto, 862-0976, Japan. yfuji@kumamoto-u.ac.jp.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Fujiwara
authors.affiliation: Radiological Center, Fukui Prefectural Hospital, 2-8-1 Yotui, Fukui, 910-8526, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Muranaka
mesh_terms: D000328:Adult; D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D019047:Phantoms, Imaging
keywords: Arterial spin labeling; Artifact; Carotid artery; Magnetic resonance angiography; Ultrashort echo time