title: CYP4F2 (rs2108622) Gene Polymorphism Association with Age-Related Macular Degeneration.
abstract: Background. Age-related macular degeneration is the leading cause of blindness in elderly individuals where aetiology and pathophysiology of age-related macular degeneration are not absolutely clear. Purpose. To determine the frequency of the genotype of rs2108622 in patients with early and exudative age-related macular degeneration. Methods. The study enrolled 190 patients with early age-related macular degeneration, 181 patients with exudative age-related macular degeneration (eAMD), and a random sample of 210 subjects from the general population (control group). The genotyping of rs2108622 was carried out using the real-time polymerase chain reaction method. Results. The analysis of rs2108622 gene polymorphism did not reveal any differences in the distribution of C/C, C/T, and T/T genotypes between the early AMD group, the eAMD group, and the control group. The CYP4F2 (1347C>T) T/T genotype was more frequent in males with eAMD compared to females (10.2% versus 0.8%; p = 0.0052); also T/T genotype was less frequently present in eAMD females compared to healthy control females (0.8% versus 6.2%; p = 0.027). Conclusion. Rs2108622 gene polymorphism had no predominant effect on the development of early AMD and eAMD. The T/T genotype was more frequent in males with eAMD compared to females and less frequently present in eAMD females compared to healthy females.
authors.affiliation: Lithuanian University of Health Sciences, Medical Academy, Eiveniu 2, LT-50009 Kaunas, Lithuania.
authors.forename: Ruta
authors.identifier: 0000-0002-8382-5192
authors.initials: R
authors.lastname: Sakiene
authors.affiliation: Neuroscience Institute, Lithuanian University of Health Sciences, Medical Academy, Eiveniu 2, LT-50009 Kaunas, Lithuania.
authors.forename: Alvita
authors.identifier: 0000-0002-0427-5568
authors.initials: A
authors.lastname: Vilkeviciute
authors.affiliation: Neuroscience Institute, Lithuanian University of Health Sciences, Medical Academy, Eiveniu 2, LT-50009 Kaunas, Lithuania; Department of Ophthalmology, Lithuanian University of Health Sciences, Medical Academy, Eiveniu 2, LT-50009 Kaunas, Lithuania.
authors.forename: Loresa
authors.initials: L
authors.lastname: Kriauciuniene
authors.affiliation: Department of Ophthalmology, Lithuanian University of Health Sciences, Medical Academy, Eiveniu 2, LT-50009 Kaunas, Lithuania.
authors.forename: Vilma Jurate
authors.initials: VJ
authors.lastname: Balciuniene
authors.affiliation: Department of Ophthalmology, Lithuanian University of Health Sciences, Medical Academy, Eiveniu 2, LT-50009 Kaunas, Lithuania.
authors.forename: Dovile
authors.initials: D
authors.lastname: Buteikiene
authors.affiliation: Department of Ophthalmology, Lithuanian University of Health Sciences, Medical Academy, Eiveniu 2, LT-50009 Kaunas, Lithuania.
authors.forename: Goda
authors.initials: G
authors.lastname: Miniauskiene
authors.affiliation: Neuroscience Institute, Lithuanian University of Health Sciences, Medical Academy, Eiveniu 2, LT-50009 Kaunas, Lithuania; Department of Ophthalmology, Lithuanian University of Health Sciences, Medical Academy, Eiveniu 2, LT-50009 Kaunas, Lithuania.
authors.forename: Rasa
authors.initials: R
authors.lastname: Liutkeviciene