title: The Role of Fecal Calprotectin in Evaluating Intestinal Involvement of Behçet's Disease.
abstract: One of the regions of involvement of Behçet's disease (BD), a systematic inflammatory vasculitis with unknown etiology, is the gastrointestinal (GI) tract. Upper GI endoscopy, colonoscopy, and capsule endoscopy are frequently used methods to diagnose the intestinal involvement of BD. The aim of this study was to investigate the role of fecal calprotectin (FC) in the evaluation of intestinal involvement in BD. Material and Method. A total of 30 patients who were diagnosed with BD and had no GI symptoms and 25 individuals in the control group were included in this study. Results. Levels of FC were statistically significantly higher in patients with BD compared to the control group (p < 0.001). The correlation analysis performed including FC and markers of disease activity revealed a positive and statistically significant correlation between FC level and CRP and erythrocyte sedimentation rate (r: 0.255, p < 0.049, and r: 0.404, p < 0.001, resp.). FC levels in patients who were detected to have ulcers in the terminal ileum and colon in the colonoscopic examination were statistically significantly higher compared to the patients with BD without intestinal involvement (p = 0.01). Conclusion. The measurement of FC levels, in patients with BD who are asymptomatic for GI involvement, may be helpful to detect the possible underlying intestinal involvement.
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Muğla Sıtkı Koçman University, 48000 Muğla, Turkey.
authors.forename: Burak
authors.identifier: 0000-0001-5429-513X
authors.initials: B
authors.lastname: Özşeker
authors.affiliation: Department of Internal Medicine, School of Medicine, Muğla Sıtkı Koçman University, 48000 Muğla, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Şahin
authors.affiliation: Department of Pathology, Education and Research Hospital, Muğla Sıtkı Koçman University, 48000 Muğla, Turkey.
authors.forename: Havva Solak
authors.initials: HS
authors.lastname: Özşeker
authors.affiliation: Gastroenterology Unit, Batman State Hospital, 72070 Batman, Turkey.
authors.forename: S Cumali
authors.initials: SC
authors.lastname: Efe
authors.affiliation: Department of Internal Medicine, Division of Gastroenterology, School of Medicine, Hacettepe University, 06230 Ankara, Turkey.
authors.forename: Taylan
authors.identifier: 0000-0003-2879-7739
authors.initials: T
authors.lastname: Kav
authors.affiliation: Department of Internal Medicine, Division of Gastroenterology, School of Medicine, Hacettepe University, 06230 Ankara, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Bayraktar
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000378:metabolism / Q000473:pathology*; D015415:Biomarkers / Q000378:metabolism*; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D005243:Feces / Q000737:chemistry*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000473:pathology*; D039841:Leukocyte L1 Antigen Complex / Q000378:metabolism*; D008297:Male; D011379:Prognosis; D012372:ROC Curve; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D039841:Leukocyte L1 Antigen Complex; D002097:C-Reactive Protein