title: Mechanisms and significance of brain glucose signaling in energy balance, glucose homeostasis, and food-induced reward.
abstract: The concept that hypothalamic glucose signaling plays an important role in regulating energy balance, e.g., as instantiated in the so-called "glucostat" hypothesis, is one of the oldest in the field of metabolism. However the mechanisms by which neurons in the hypothalamus sense glucose, and the function of glucose signaling in the brain, has been difficult to establish. Nevertheless recent studies probing mechanisms of glucose signaling have also strongly supported a role for glucose signaling in regulating energy balance, glucose homeostasis, and food-induced reward.
authors.affiliation: Department of Neuroscience, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave., 9-119, New York, NY 10029, USA; Department of Endocrinology, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave., 9-119, New York, NY 10029, USA.
authors.forename: Kavya
authors.initials: K
authors.lastname: Devarakonda
authors.affiliation: Department of Neuroscience, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave., 9-119, New York, NY 10029, USA; Department of Endocrinology, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave., 9-119, New York, NY 10029, USA; Department of Geriatrics, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave., 9-119, New York, NY 10029, USA. Electronic address: charles.mobbs@mssm.edu.
authors.forename: Charles V
authors.initials: CV
authors.lastname: Mobbs
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D004734:Energy Metabolism; D005502:Food; D005947:Glucose / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D012201:Reward; D015398:Signal Transduction
chemical_list: D005947:Glucose
keywords: Diabetes; Glucose; Hypothalamus; Obesity; Reward; Signaling