title: Polymorphisms in exon 2 of CD1 genes are associated with susceptibility to Guillain-Barré syndrome.
abstract: Guillain-Barré syndrome (GBS) is a post-infectious autoimmune peripheral neuropathy. Studies have shown that a T cell-mediated immune response to peripheral nerve is associated with the pathogenesis of GBS. CD1 molecules are MCH-like glycoproteins specialized to capture and present glycolipids to T cells. Polymorphisms of CD1 genes may affect susceptibility to GBS. We investigated the polymorphisms of CD1 genes in GBS patients in a Chinese Han population. In 126 patients and in 138 controls we genotyped exon 2 of the CD1A and CD1E genes. The results indicated that polymorphisms of CD1A genes are associated with GBS. Furthermore, subjects with CD1A*01/02 had a 2.9 times lower risk of developing GBS, and those with CD1A*02/02 had a 2.5 times higher risk to developing GBS than the controls, while there was no association between polymorphisms of CD1E genes and the susceptibilities to GBS.
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Henan, People's Republic of China. Electronic address: liuhongbo6279@126.com.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Henan, People's Republic of China.
authors.forename: Yanmeng
authors.initials: Y
authors.lastname: Xing
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Henan, People's Republic of China.
authors.forename: Yake
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Department of Neurosurgery, General Hospital, Tianjin Medical University, Tianjin, People's Republic of China.
authors.forename: Peidong
authors.initials: P
authors.lastname: Liu
authors.affiliation: Department of Neurology, Xuanwu Hospital, Affiliated to Capital Medical University, Beijing, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Henan, People's Republic of China.
authors.forename: Bing
authors.initials: B
authors.lastname: Xue
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Henan, People's Republic of China.
authors.forename: Jifei
authors.initials: J
authors.lastname: Shou
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Henan, People's Republic of China.
authors.forename: Juanfeng
authors.initials: J
authors.lastname: Qian
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Henan, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Peng
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Henan, People's Republic of China.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Henan, People's Republic of China.
authors.forename: YiWei
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Henan, People's Republic of China.
authors.forename: Shuyou
authors.initials: S
authors.lastname: Fang
mesh_terms: D000293:Adolescent; D000328:Adult; D018949:Antigens, CD1 / Q000235:genetics*; D002648:Child; D005091:Exons / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D020275:Guillain-Barre Syndrome / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D055815:Young Adult
chemical_list: D018949:Antigens, CD1
keywords: CD1 genes polymorphism; Glycolipid presentation; Guillain–Barré syndrome