title: Submandibular oncocytic carcinoma: A case report and literature review.
abstract: BACKGROUND
  Oncocytic carcinoma (OC) arising in the submandibular gland is an unusual malignant neoplasm, with <20 cases previously reported. The cancer is characterized by numerous morphologically abnormal mitochondria present in the cytoplasm and marked cellular pleomorphism. At its most severe, the tumor may invade into the surrounding tissues, including intravascular, lymphatic, or perineural invasion, and lead to regional nodal or distant metastasis.
  
  
  METHODS
  The current study describes a novel OC case in a 46-year-old male, the youngest case of the review. The patient presented with a 5-month history of an intermittently painful mass.
  
  
  RESULTS
  Following magnetic resonance imaging, excisional biopsy, hematoxylin-eosin staining, phosphotungstic acid-hematoxylin staining, and immunohistochemical examination, an OC of the submandibular gland was diagnosed.
  
  
  CONCLUSIONS
  The current study summarizes the pathogenesis, diagnosis, therapeutics, and the prognosis of OC. The literature review regarding this rare disease is also presented to emphasize the lack of specific markers of OC and the risk of cervical lymph metastasis.
authors.affiliation: Department of Pathology College of Basic Medical Sciences, Gannan Medical University Department of Stomatology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, P.R. China.
authors.forename: Hai
authors.initials: H
authors.lastname: Xiao
authors.forename: Tingyu
authors.initials: T
authors.lastname: Wen
authors.forename: Xinzheng
authors.initials: X
authors.lastname: Liu
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000473:pathology*; D006801:Humans; D008297:Male; D024862:Oxyphil Cells; D013363:Submandibular Gland / Q000473:pathology*; D013365:Submandibular Gland Neoplasms / Q000473:pathology*