title: Antifungal activity of 1'-homo-N-1,2,3-triazol-bicyclic carbonucleosides: A novel type of compound afforded by azide-enolate (3+2) cycloaddition.
abstract: The first report of 1'-homo-N-1,2,3-triazol-bicyclic carbonucleosides (7a and 7b) is described herein. Azide-enolate (3+2) cycloaddition afforded the synthesis of this novel type of compound. Antifungal activity was evaluated in vitro against four filamentous fungi (Aspergillus fumigatus, Trichosporon cutaneum, Rhizopus oryzae and Mucor hiemalis) as well as nine species of Candida spp. as yeast specimens. These pre-clinical studies suggest that compounds 7a and 7b are promising candidates for complementary biological studies due to their good activity against Candida spp.
authors.affiliation: Departamento de Química Orgánica, Facultad de Química, Universidad Autónoma del Estado de México, Paseo Colón/Paseo Tollocan s/n, Toluca, Estado de México 50120, Mexico. Electronic address: qfb_dgonzalez@yahoo.com.mx.
authors.forename: Davir
authors.initials: D
authors.lastname: González-Calderón
authors.affiliation: Departamento de Química Orgánica, Facultad de Química, Universidad Autónoma del Estado de México, Paseo Colón/Paseo Tollocan s/n, Toluca, Estado de México 50120, Mexico.
authors.forename: María G
authors.initials: MG
authors.lastname: Mejía-Dionicio
authors.affiliation: Departamento de Química Orgánica, Facultad de Química, Universidad Autónoma del Estado de México, Paseo Colón/Paseo Tollocan s/n, Toluca, Estado de México 50120, Mexico.
authors.forename: Marco A
authors.initials: MA
authors.lastname: Morales-Reza
authors.affiliation: Departamento de Química Orgánica, Facultad de Química, Universidad Autónoma del Estado de México, Paseo Colón/Paseo Tollocan s/n, Toluca, Estado de México 50120, Mexico.
authors.forename: José G
authors.initials: JG
authors.lastname: Aguirre-de Paz
authors.affiliation: Departamento de Química Orgánica, Facultad de Química, Universidad Autónoma del Estado de México, Paseo Colón/Paseo Tollocan s/n, Toluca, Estado de México 50120, Mexico.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Ramírez-Villalva
authors.affiliation: Departamento de Microbiología, Facultad de Química, Universidad Autónoma del Estado de México, Paseo Colón/Paseo Tollocan s/n, Toluca, Estado de México 50120, Mexico.
authors.forename: Macario
authors.initials: M
authors.lastname: Morales-Rodríguez
authors.affiliation: Departamento de Química Orgánica, Facultad de Química, Universidad Autónoma del Estado de México, Paseo Colón/Paseo Tollocan s/n, Toluca, Estado de México 50120, Mexico.
authors.forename: Aydeé
authors.initials: A
authors.lastname: Fuentes-Benítes
authors.affiliation: Departamento de Química Orgánica, Facultad de Química, Universidad Autónoma del Estado de México, Paseo Colón/Paseo Tollocan s/n, Toluca, Estado de México 50120, Mexico. Electronic address: cgonzalezr@uaemex.mx.
authors.forename: Carlos
authors.initials: C
authors.lastname: González-Romero
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects; D001386:Azides / Q000737:chemistry*; D061565:Cycloaddition Reaction; D004305:Dose-Response Relationship, Drug; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D009089:Mucor / Q000187:drug effects; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012233:Rhizopus / Q000187:drug effects; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D014250:Trichosporon / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D001386:Azides; D009705:Nucleosides; D014230:Triazoles
keywords: 1,2,3-Triazole; 1′-Homonucleosides; Antifungal activity; Azide-enolate cycloaddition