title: A structure-based kinetic model of transcription.
abstract: During transcription, RNA polymerase moves downstream along the DNA template and maintains a transcription bubble. Several recent structural studies of transcription complexes with a complete transcription bubble provide new insights into how RNAP couples the nucleotide addition reaction to its directional movement.
authors.affiliation: a Department of Molecular Biophysics and Biochemistry , Yale University , New Haven , CT , USA.
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Zuo
authors.affiliation: a Department of Molecular Biophysics and Biochemistry , Yale University , New Haven , CT , USA.|b Howard Hughes Medical Institute , New Haven , CT , USA.|c Department of Chemistry , Yale University , New Haven , CT , USA.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Steitz
mesh_terms: D004247:DNA / Q000737:chemistry / Q000235:genetics*; D012321:DNA-Directed RNA Polymerases / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D014158:Transcription, Genetic
chemical_list: D004247:DNA; D012321:DNA-Directed RNA Polymerases
keywords: RNA polymerase; nucleotide addition cycle; pyrophosphate release; transcription bubble; transcription elongation; transcription initiation; translocation