title: Re-Treatment With Ethambutol After Toxic Optic Neuropathy.
abstract: There are no data in the literature regarding the safety of re-treatment with ethambutol for recurrent mycobacterial infection after prior ethambutol-induced optic neuropathy. We describe a patient who developed optic neuropathy attributed to ethambutol, recovered fully after drug withdrawal, and tolerated a 14-month long re-treatment 10 years later without developing recurrent optic neuropathy.
authors.affiliation: Department of Neurology (MAB, NT), Beth Israel Deaconess Medical Center, Boston, Massachusetts; Division of Infectious Disease (RRN, DY), Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts; and Division of Ophthalmology (NT), Department of Surgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
authors.forename: Marc A
authors.initials: MA
authors.lastname: Bouffard
authors.forename: Ruvandhi R
authors.initials: RR
authors.lastname: Nathavitharana
authors.forename: David S
authors.initials: DS
authors.lastname: Yassa
authors.forename: Nurhan
authors.initials: N
authors.lastname: Torun
mesh_terms: D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004977:Ethambutol / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D015269:Mycobacterium avium Complex / Q000302:isolation & purification; D015270:Mycobacterium avium-intracellulare Infection / Q000188:drug therapy* / Q000382:microbiology; D009901:Optic Nerve Diseases / Q000139:chemically induced* / Q000175:diagnosis; D012165:Retinal Ganglion Cells / Q000473:pathology*; D019233:Retreatment
chemical_list: D000995:Antitubercular Agents; D004977:Ethambutol