title: Correlations of Hepatic Hemodynamics, Liver Function, and Fibrosis Markers in Nonalcoholic Fatty Liver Disease: Comparison with Chronic Hepatitis Related to Hepatitis C Virus.
abstract: The progression of chronic liver disease differs by etiology. The aim of this study was to elucidate the difference in disease progression between chronic hepatitis C (CHC) and nonalcoholic fatty liver disease (NAFLD) by means of fibrosis markers, liver function, and hepatic tissue blood flow (TBF). Xenon computed tomography (Xe-CT) was performed in 139 patients with NAFLD and 152 patients with CHC (including liver cirrhosis (LC)). The cutoff values for fibrosis markers were compared between NAFLD and CHC, and correlations between hepatic TBF and liver function tests were examined at each fibrosis stage. The cutoff values for detection of the advanced fibrosis stage were lower in NAFLD than in CHC. Although portal venous TBF (PVTBF) correlated with liver function tests, PVTBF in initial LC caused by nonalcoholic steatohepatitis (NASH-LC) was significantly lower than that in hepatitis C virus (C-LC) (p = 0.014). Conversely, the liver function tests in NASH-LC were higher than those in C-LC (p < 0.05). It is important to recognize the difference between NAFLD and CHC. We concluded that changes in hepatic blood flow occurred during the earliest stage of hepatic fibrosis in patients with NAFLD; therefore, patients with NAFLD need to be followed carefully.
authors.affiliation: Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kanagawa, Kawasaki 216-8511, Japan. r2shigefuku@marianna-u.ac.jp.
authors.forename: Ryuta
authors.initials: R
authors.lastname: Shigefuku
authors.affiliation: Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kanagawa, Kawasaki 216-8511, Japan. hide-bo@marianna-u.ac.jp.|Division of Gastroenterology, St. Marianna University School of Medicine, Yokohama City Seibu Hospital, Kanagawa, Yokohama 241-0811, Japan. hide-bo@marianna-u.ac.jp.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Takahashi
authors.affiliation: Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kanagawa, Kawasaki 216-8511, Japan. h-nakano@marianna-u.ac.jp.
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Nakano
authors.affiliation: Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kanagawa, Kawasaki 216-8511, Japan. twatanab@marianna-u.ac.jp.
authors.forename: Tsunamasa
authors.initials: T
authors.lastname: Watanabe
authors.affiliation: Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kanagawa, Kawasaki 216-8511, Japan. kotarom@marianna-u.ac.jp.
authors.forename: Kotaro
authors.initials: K
authors.lastname: Matsunaga
authors.affiliation: Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kanagawa, Kawasaki 216-8511, Japan. nobu1020@marianna-u.ac.jp.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Matsumoto
authors.affiliation: Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kanagawa, Kawasaki 216-8511, Japan. masaki0801_3@marianna-u.ac.jp.
authors.forename: Masaki
authors.initials: M
authors.lastname: Kato
authors.affiliation: Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kanagawa, Kawasaki 216-8511, Japan. r2morita@marianna-u.ac.jp.
authors.forename: Ryo
authors.initials: R
authors.lastname: Morita
authors.affiliation: Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kanagawa, Kawasaki 216-8511, Japan. y2michikawa@marianna-u.ac.jp.
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Michikawa
authors.affiliation: Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kanagawa, Kawasaki 216-8511, Japan. t2tamura@marianna-u.ac.jp.|Division of Gastroenterology, St. Marianna University School of Medicine, Yokohama City Seibu Hospital, Kanagawa, Yokohama 241-0811, Japan. t2tamura@marianna-u.ac.jp.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Tamura
authors.affiliation: Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kanagawa, Kawasaki 216-8511, Japan. t2hiraishi@marianna-u.ac.jp.|Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kawasaki Municipal Tama Hospital, Kanagawa, Kawasaki 214-8525, Japan. t2hiraishi@marianna-u.ac.jp.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Hiraishi
authors.affiliation: Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kanagawa, Kawasaki 216-8511, Japan. hattyorina.224@gmail.com.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Hattori
authors.affiliation: Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kanagawa, Kawasaki 216-8511, Japan. y2noguchi@marianna-u.ac.jp.|Division of Gastroenterology, St. Marianna University School of Medicine, Yokohama City Seibu Hospital, Kanagawa, Yokohama 241-0811, Japan. y2noguchi@marianna-u.ac.jp.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Noguchi
authors.affiliation: Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kanagawa, Kawasaki 216-8511, Japan. nakahara@marianna-u.ac.jp.
authors.forename: Kazunari
authors.initials: K
authors.lastname: Nakahara
authors.affiliation: Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kanagawa, Kawasaki 216-8511, Japan. ikedahi@marianna-u.ac.jp.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ikeda
authors.affiliation: Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kanagawa, Kawasaki 216-8511, Japan. t2ishii@marianna-u.ac.jp.|Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kawasaki Municipal Tama Hospital, Kanagawa, Kawasaki 214-8525, Japan. t2ishii@marianna-u.ac.jp.
authors.forename: Toshiya
authors.initials: T
authors.lastname: Ishii
authors.affiliation: Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kanagawa, Kawasaki 216-8511, Japan. c2okuse@marianna-u.ac.jp.|Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kawasaki Municipal Tama Hospital, Kanagawa, Kawasaki 214-8525, Japan. c2okuse@marianna-u.ac.jp.
authors.forename: Chiaki
authors.initials: C
authors.lastname: Okuse
authors.affiliation: Anzai Medical Company, Ltd., Tokyo 141-0033, Japan. sase@anzai-med.co.jp.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Sase
authors.affiliation: Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kanagawa, Kawasaki 216-8511, Japan. fitoh@marianna-u.ac.jp.
authors.forename: Fumio
authors.initials: F
authors.lastname: Itoh
authors.affiliation: Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kanagawa, Kawasaki 216-8511, Japan. michstmu@marianna-u.ac.jp.|Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kawasaki Municipal Tama Hospital, Kanagawa, Kawasaki 214-8525, Japan. michstmu@marianna-u.ac.jp.
authors.forename: Michihiro
authors.initials: M
authors.lastname: Suzuki
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D018450:Disease Progression; D005260:Female; D006439:Hemodynamics; D016174:Hepacivirus / Q000502:physiology; D019698:Hepatitis C, Chronic / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology* / Q000821:virology; D054884:Host-Pathogen Interactions; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D008111:Liver Function Tests / Q000379:methods; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D012372:ROC Curve; D012039:Regional Blood Flow / Q000502:physiology; D014057:Tomography, X-Ray Computed / Q000379:methods; D014978:Xenon
chemical_list: D015415:Biomarkers; D014978:Xenon
keywords: WFA+-M2BP; chronic hepatitis C; hepatic hemodynamics; liver function; nonalcoholic steatohepatitis