title: Molecular and Electrophysiological Mechanisms Underlying Cardiac Arrhythmogenesis in Diabetes Mellitus.
abstract: Diabetes is a common endocrine disorder with an ever increasing prevalence globally, placing significant burdens on our healthcare systems. It is associated with significant cardiovascular morbidities. One of the mechanisms by which it causes death is increasing the risk of cardiac arrhythmias. The aim of this article is to review the cardiac (ion channel abnormalities, electrophysiological and structural remodelling) and extracardiac factors (neural pathway remodelling) responsible for cardiac arrhythmogenesis in diabetes. It is concluded by an outline of molecular targets for future antiarrhythmic therapy for the diabetic population.
authors.affiliation: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.
authors.forename: Gary
authors.identifier: 0000-0001-5510-1253
authors.initials: G
authors.lastname: Tse
authors.affiliation: School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong.
authors.forename: Eric Tsz Him
authors.identifier: 0000-0002-8712-0042
authors.initials: ET
authors.lastname: Lai
authors.affiliation: Department of Physiology, McGill University, Montreal, QC, Canada H3G 1Y6.
authors.forename: Vivian
authors.initials: V
authors.lastname: Tse
authors.affiliation: School of Medicine, Imperial College London, London SW7 2AZ, UK.
authors.forename: Jie Ming
authors.initials: JM
authors.lastname: Yeo
mesh_terms: D000200:Action Potentials; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D002118:Calcium / Q000378:metabolism*; D009202:Cardiomyopathies / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D016757:Death, Sudden, Cardiac / Q000209:etiology; D003920:Diabetes Mellitus / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D007473:Ion Channels / Q000378:metabolism*; D017202:Myocardial Ischemia / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D007473:Ion Channels; D002118:Calcium