title: A regeneration-based, nonobturation root-canal treatment for fully-mature teeth: Six years' experience with "SealBio".
abstract: OBJECTIVE
  To provide scientific evidence on the outcome of a large number of cases treated by SealBio over the longer follow-up period.
  
  
  METHODS
  One hundred and thirty-four teeth in 116 patients presenting with pulp and periapical disease were randomly recruited between 2009 and 2014. SealBio was performed, and cases were followed up at regular intervals up to 6-year.
  
  
  RESULTS
  Of the total 134 teeth treated, 16 teeth could not be followed up and 9 cases failed (7.62% of cases). In only 4 cases (approximately 3.38% of cases), the failure could be directly attributed to endodontic causes. In the remaining 5 cases, coronal leakage from under the crown margins or dislodged restoration was found after 3-5 years of treatment.
  
  
  CONCLUSIONS
  SealBio was found to be a successful, nonobturation, regeneration-based endodontic treatment protocol. By cell homing of endogenous stem cells, a biological seal rather than an artificial seal with gutta-percha and sealer cement is possible to achieve. It is highly cost saving and easier to perform, in addition to other advantages, such as retreatment is much simpler, and postcore restoration is possible after SealBio treatment.
authors.affiliation: Department of Dentistry, Hindu Rao Hospital, North Delhi Municipal Corporation Medical College, New Delhi, India.
authors.forename: Naseem
authors.initials: N
authors.lastname: Shah
keywords: Endogenous stem cells; SealBio; homing of stem cells; nonobturation root canal treatment; periapical healing; regenerative endodontic treatment