title: Erectile dysfunction in young men with type 1 diabetes.
abstract: Erectile dysfunction (ED) is a common comorbidity of diabetes mellitus, but few studies investigated its prevalence in type 1 diabetes. The objective of this study was to evaluate the prevalence and correlates of ED in young men with type 1 diabetes treated with different intensive insulin regimens. The study population included 151 type 1 diabetic men, aged 18-35 years, and 60 healthy age-matched controls. Ninety-four men were treated with multiple daily injections of insulin (MDI), and the remaining 71 with continuous subcutaneous insulin infusion (CSII). All participants in the study completed the International Index of Erectile function (IIEF-5), and other validated multiple-choice questionnaires assessing quality of life, physical activity, depressive symptoms and diabetes-related problems. The overall prevalence of ED was higher in diabetic men (37%), as compared with controls (6%, P<0.001). ED prevalence rates were similar in both MDI (36%) and CSII (39%) groups (P=0.326); both were higher compared with controls (P<0.001 for both). More than half of diabetic men (58%) had mild ED. Compared with men without ED, diabetic men with ED showed lower weight, body mass index, fasting glucose, insulin dose and high-density lipoprotein cholesterol levels, and higher self-rating depression score (SRDS). In the multiple regression analysis only the SRDS (P=0.032) were independent predictors of IIEF-5 score in the overall diabetic men. Young men with type 1 diabetes treated with MDI or CSII show a higher prevalence of ED, as compared with healthy age-matched men. Depression was associated with ED in diabetic population.
authors.affiliation: Endocrinology and Metabolic Diseases Unit, Department of Medical, Surgical, Neurological, Metabolic Sciences and Aging, Second University of Naples, Naples, Italy.
authors.forename: M I
authors.initials: MI
authors.lastname: Maiorino
authors.affiliation: Endocrinology and Metabolic Diseases Unit, Department of Medical, Surgical, Neurological, Metabolic Sciences and Aging, Second University of Naples, Naples, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Bellastella
authors.affiliation: Endocrinology and Metabolic Diseases Unit, Department of Medical, Surgical, Neurological, Metabolic Sciences and Aging, Second University of Naples, Naples, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Della Volpe
authors.affiliation: Endocrinology and Metabolic Diseases Unit, Department of Medical, Surgical, Neurological, Metabolic Sciences and Aging, Second University of Naples, Naples, Italy.
authors.forename: O
authors.initials: O
authors.lastname: Casciano
authors.affiliation: Endocrinology and Metabolic Diseases Unit, Department of Medical, Surgical, Neurological, Metabolic Sciences and Aging, Second University of Naples, Naples, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Scappaticcio
authors.affiliation: Endocrinology and Metabolic Diseases Unit, Department of Medical, Surgical, Neurological, Metabolic Sciences and Aging, Second University of Naples, Naples, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Cirillo
authors.affiliation: Endocrinology and Metabolic Diseases Unit, Department of Medical, Surgical, Neurological, Metabolic Sciences and Aging, Second University of Naples, Naples, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Giugliano
authors.affiliation: Diabetes Unit, Department of Medical, Surgical, Neurological, Metabolic Sciences and Aging, Second University of Naples, Naples, Italy.
authors.forename: K
authors.initials: K
authors.lastname: Esposito
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D003863:Depression; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000188:drug therapy*; D007172:Erectile Dysfunction / Q000453:epidemiology* / Q000523:psychology*; D015444:Exercise; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use*; D007332:Insulin Infusion Systems; D007558:Italy; D008137:Longitudinal Studies; D008297:Male; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D012307:Risk Factors; D057566:Self Report; D013997:Time Factors; D055815:Young Adult
chemical_list: D007328:Insulin