title: Effect of Chinese Herbal Medicine Jinlida Granule in Treatment of Patients with Impaired Glucose Tolerance.
abstract: BACKGROUND
  Diabetes mellitus (DM) remains a major health problem worldwide. Several clinical trials have shown the superiority of the Traditional Chinese Medicine in delaying or reversing the development and progression of DM. This study aimed to evaluate the efficacy of Jinlida (JLD) granule, a Chinese herbal recipe, in the treatment of impaired glucose tolerance (IGT) and its effect on the prevention of DM.
  
  
  METHODS
  Sixty-five IGT patients were randomized to receive one bag of JLD granules three times daily (JLD group, n = 34) or no drug intervention (control group, n = 31) for 12 weeks. Oral glucose tolerance test, glycated hemoglobin A1c (HbA1c), body mass index, blood lipids levels, fasting insulin, and insulin resistance calculated using homeostatic model assessment (HOMA-IR) of all the patients were observed and compared before and after the treatment.
  
  
  RESULTS
  Sixty-one participants completed the trial (32 in JLD group and 29 in the control group). There were statistically significant decreases in HbA1c (P < 0.001), 2-h plasma glucose (P < 0.001), and HOMA-IR (P = 0.029) in JLD group compared with the control group after 12 weeks of treatment. After 12 weeks of treatment, two (6.9%) patients returned to normal blood glucose, and five (17.2%) patients turned into DM in control group, while in the JLD group, 14 (43.8%) returned to normal blood glucose and 2 (6.2%) turned into DM. There was a significant difference in the number of subjects who had normal glucose at the end of the study between two groups (P = 0.001).
  
  
  CONCLUSIONS
  JLD granule effectively improved glucose control, increased the conversion of IGT to normal glucose, and improved the insulin resistance in patients with IGT. This Chinese herbal medicine may have a clinical value for IGT.
authors.affiliation: Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003; Department of Medical Sciences, Medical College, Xiamen University, Xiamen, Fujian 361000, China.
authors.forename: Ya-Lin
authors.initials: YL
authors.lastname: Shi
authors.affiliation: Department of Endocrinology, Zhangzhou Affiliated Traditional Chinese Medicine Hospital of Fujian University of Traditional Chinese Medicine, Zhangzhou, Fujian 363000, China.
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Liu
authors.affiliation: Department of Medical Sciences, Medical College, Xiamen University, Xiamen, Fujian 361000; Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003, China.
authors.forename: Xiao-Fang
authors.initials: XF
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003, China.
authors.forename: Wei-Juan
authors.initials: WJ
authors.lastname: Su
authors.affiliation: Department of Medical Sciences, Medical College, Xiamen University, Xiamen, Fujian 361000; Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003, China.
authors.forename: Ning-Ning
authors.initials: NN
authors.lastname: Chen
authors.affiliation: Department of Medical Sciences, Medical College, Xiamen University, Xiamen, Fujian 361000; Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003, China.
authors.forename: Shu-Hua
authors.initials: SH
authors.lastname: Lu
authors.affiliation: Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003, China.
authors.forename: Li-Ying
authors.initials: LY
authors.lastname: Wang
authors.affiliation: Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003, China.
authors.forename: Xiu-Lin
authors.initials: XL
authors.lastname: Shi
authors.affiliation: Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003; Epidemiology Research Unit, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361000, China.
authors.forename: Zhi-Bin
authors.initials: ZB
authors.lastname: Li
authors.affiliation: Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003, China.
authors.forename: Shu-Yu
authors.initials: SY
authors.lastname: Yang
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000187:drug effects; D015992:Body Mass Index; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000188:drug therapy*; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin; C000601818:jinlida