title: Lentiviral vector interactions with the host cell.
abstract: Lentiviral vectors (LVs)-mediated gene transfer is an efficient method for ex vivo and in vivo gene therapy. Actually, LVs have been used in several clinical trials and therapeutic correction was reached in affected patients. However, in order to be effective gene therapy needs to be efficient without detrimental effects for target cells. Successful cell transduction by LVs can be hampered by several factors such as the activation of innate immune sensors during cell transduction and different restriction factors (RFs) inhibiting viral replication inside the cells. Therefore, a better knowledge of host-vector interactions is important for the development of more efficient gene therapy strategies improving the LVs platform by limiting harmful responses.
authors.affiliation: Department of Health Sciences, Università del Piemonte Orientale "A. Avogadro", Novara 28100, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Borsotti
authors.affiliation: Department of Health Sciences, Università del Piemonte Orientale "A. Avogadro", Novara 28100, Italy.
authors.forename: Ester
authors.initials: E
authors.lastname: Borroni
authors.affiliation: Department of Health Sciences, Università del Piemonte Orientale "A. Avogadro", Novara 28100, Italy. Electronic address: antonia.follenzi@med.uniupo.it.
authors.forename: Antonia
authors.initials: A
authors.lastname: Follenzi
mesh_terms: D004337:Drug Carriers; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D016086:Lentivirus / Q000235:genetics / Q000276:immunology* / Q000502:physiology*; D014161:Transduction, Genetic
chemical_list: D004337:Drug Carriers