title: Networks Models of Actin Dynamics during Spermatozoa Postejaculatory Life: A Comparison among Human-Made and Text Mining-Based Models.
abstract: Here we realized a networks-based model representing the process of actin remodelling that occurs during the acquisition of fertilizing ability of human spermatozoa (HumanMade_ActinSpermNetwork, HM_ASN). Then, we compared it with the networks provided by two different text mining tools: Agilent Literature Search (ALS) and PESCADOR. As a reference, we used the data from the online repository Kyoto Encyclopaedia of Genes and Genomes (KEGG), referred to the actin dynamics in a more general biological context. We found that HM_ALS and the networks from KEGG data shared the same scale-free topology following the Barabasi-Albert model, thus suggesting that the information is spread within the network quickly and efficiently. On the contrary, the networks obtained by ALS and PESCADOR have a scale-free hierarchical architecture, which implies a different pattern of information transmission. Also, the hubs identified within the networks are different: HM_ALS and KEGG networks contain as hubs several molecules known to be involved in actin signalling; ALS was unable to find other hubs than "actin," whereas PESCADOR gave some nonspecific result. This seems to suggest that the human-made information retrieval in the case of a specific event, such as actin dynamics in human spermatozoa, could be a reliable strategy.
authors.affiliation: Faculty of Veterinary Medicine, University of Teramo, Via Renato Balzarini 1, 64100 Teramo, Italy.
authors.forename: Nicola
authors.identifier: 0000-0001-5140-9656
authors.initials: N
authors.lastname: Bernabò
authors.affiliation: Faculty of Veterinary Medicine, University of Teramo, Via Renato Balzarini 1, 64100 Teramo, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Ordinelli
authors.affiliation: Faculty of Veterinary Medicine, University of Teramo, Via Renato Balzarini 1, 64100 Teramo, Italy.
authors.forename: Marina
authors.initials: M
authors.lastname: Ramal Sanchez
authors.affiliation: Faculty of Veterinary Medicine, University of Teramo, Via Renato Balzarini 1, 64100 Teramo, Italy; Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise "G. Caporale", Campo Boario, 64100 Teramo, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Mattioli
authors.affiliation: Faculty of Veterinary Medicine, University of Teramo, Via Renato Balzarini 1, 64100 Teramo, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Barboni
mesh_terms: D000199:Actins / Q000378:metabolism*; D004542:Ejaculation / Q000502:physiology; D005306:Fertilization / Q000502:physiology*; D006801:Humans; D008297:Male; D013094:Spermatozoa / Q000502:physiology*
chemical_list: D000199:Actins