title: The efficacy of febuxostat 10 mg for the prevention of hyperuricemia associated with tumor lysis syndrome (TLS) in Japanese patients with non-Hodgkin's lymphoma .
abstract: Tumor lysis syndrome (TLS) is a life-threatening oncologic emergency. The control of serum uric acid level (UA) is important for prevention of TLS. Febuxostat has demonstrated its superiority over allopurinol in decreasing UA level. We retrospectively evaluated the efficacy of febuxostat 10 mg in prevention of hyperuricemia associated with TLS (HU-TLS) in 12 patients with non-Hodgkin's lymphoma (NHL). Mean UA levels were found to significantly decrease (p = 0.003). HU-TLS was prevented in all patients. Thus, febuxostat 10 mg is effective in prevention of HU-TLS. Future study is need to determine whether the incidence of HU-TLS change with dosage of febuxostat. .
authors.forename: Takeo
authors.initials: T
authors.lastname: Yasu
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Mai
authors.initials: M
authors.lastname: Horii
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Kurokawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000069465:Febuxostat / Q000627:therapeutic use*; D005260:Female; D006074:Gout Suppressants / Q000627:therapeutic use*; D006801:Humans; D033461:Hyperuricemia / Q000517:prevention & control*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015275:Tumor Lysis Syndrome / Q000150:complications*
chemical_list: D006074:Gout Suppressants; D000069465:Febuxostat