title: Degradable Organically-Derivatized Polyoxometalate with Enhanced Activity against Glioblastoma Cell Line.
abstract: High efficacy and low toxicity are critical for cancer treatment. Polyoxometalates (POMs) have been reported as potential candidates for cancer therapy. On accounts of the slow clearance of POMs, leading to long-term toxicity, the clinical application of POMs in cancer treatment is restricted. To address this problem, a degradable organoimido derivative of hexamolybdate is developed by modifying it with a cleavable organic group, leading to its degradation. Of note, this derivative exhibits favourable pharmacodynamics towards human malignant glioma cell (U251), the ability to penetrate across blood brain barrier and low toxicity towards rat pheochromocytoma cell (PC12). This line of research develops an effective POM-based agent for glioblastoma inhibition and will pave a new way to construct degradable anticancer agents for clinical cancer therapy.
authors.affiliation: Department of Chemistry, Tsinghua University, Beijing 100084, China.|State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.
authors.forename: Shan
authors.initials: S
authors.lastname: She
authors.affiliation: Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China.
authors.forename: Shengtai
authors.initials: S
authors.lastname: Bian
authors.affiliation: Laboratory Animal Center, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Ruichao
authors.initials: R
authors.lastname: Huo
authors.affiliation: Department of Chemistry, Tsinghua University, Beijing 100084, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Tsinghua University, Beijing 100084, China.
authors.forename: Zehuan
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of Chemistry, Tsinghua University, Beijing 100084, China.
authors.forename: Jiangwei
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, Tsinghua University, Beijing 100084, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Hao
authors.affiliation: Department of Chemistry, Tsinghua University, Beijing 100084, China.|State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.
authors.forename: Yongge
authors.initials: Y
authors.lastname: Wei