title: ECG imaging of ventricular tachycardia: evaluation against simultaneous non-contact mapping and CMR-derived grey zone.
abstract: ECG imaging is an emerging technology for the reconstruction of cardiac electric activity from non-invasively measured body surface potential maps. In this case report, we present the first evaluation of transmurally imaged activation times against endocardially reconstructed isochrones for a case of sustained monomorphic ventricular tachycardia (VT). Computer models of the thorax and whole heart were produced from MR images. A recently published approach was applied to facilitate electrode localization in the catheter laboratory, which allows for the acquisition of body surface potential maps while performing non-contact mapping for the reconstruction of local activation times. ECG imaging was then realized using Tikhonov regularization with spatio-temporal smoothing as proposed by Huiskamp and Greensite and further with the spline-based approach by Erem et al. Activation times were computed from transmurally reconstructed transmembrane voltages. The results showed good qualitative agreement between the non-invasively and invasively reconstructed activation times. Also, low amplitudes in the imaged transmembrane voltages were found to correlate with volumes of scar and grey zone in delayed gadolinium enhancement cardiac MR. The study underlines the ability of ECG imaging to produce activation times of ventricular electric activity-and to represent effects of scar tissue in the imaged transmembrane voltages.
authors.affiliation: Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), Kaiserstr. 12, 76131, Karlsruhe, Germany. publications@ibt.kit.edu.
authors.forename: Walther H W
authors.initials: WHW
authors.lastname: Schulze
authors.affiliation: Division of Imaging Sciences, St. Thomas' Hospital, King's College London, London, UK.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Chen
authors.affiliation: INRIA Sophia Antipolis, Sophia Antipolis, France.
authors.forename: Jatin
authors.initials: J
authors.lastname: Relan
authors.affiliation: Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), Kaiserstr. 12, 76131, Karlsruhe, Germany.
authors.forename: Danila
authors.initials: D
authors.lastname: Potyagaylo
authors.affiliation: Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), Kaiserstr. 12, 76131, Karlsruhe, Germany.|ABB AG, Corporate Research, Ladenburg, Germany.
authors.forename: Martin W
authors.initials: MW
authors.lastname: Krueger
authors.affiliation: Division of Imaging Sciences, St. Thomas' Hospital, King's College London, London, UK.
authors.forename: Rashed
authors.initials: R
authors.lastname: Karim
authors.affiliation: Division of Imaging Sciences, St. Thomas' Hospital, King's College London, London, UK.
authors.forename: Manav
authors.initials: M
authors.lastname: Sohal
authors.affiliation: Division of Imaging Sciences, St. Thomas' Hospital, King's College London, London, UK.
authors.forename: Anoop
authors.initials: A
authors.lastname: Shetty
authors.affiliation: Division of Imaging Sciences, St. Thomas' Hospital, King's College London, London, UK.
authors.forename: YingLiang
authors.initials: Y
authors.lastname: Ma
authors.affiliation: INRIA Sophia Antipolis, Sophia Antipolis, France.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Ayache
authors.affiliation: INRIA Sophia Antipolis, Sophia Antipolis, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Sermesant
authors.affiliation: INRIA Sophia Antipolis, Sophia Antipolis, France.
authors.forename: Herve
authors.initials: H
authors.lastname: Delingette
authors.affiliation: Division of Imaging Sciences, St. Thomas' Hospital, King's College London, London, UK.
authors.forename: Julian
authors.initials: J
authors.lastname: Bostock
authors.affiliation: Division of Imaging Sciences, St. Thomas' Hospital, King's College London, London, UK.
authors.forename: Reza
authors.initials: R
authors.lastname: Razavi
authors.affiliation: Division of Imaging Sciences, St. Thomas' Hospital, King's College London, London, UK.
authors.forename: Kawal S
authors.initials: KS
authors.lastname: Rhode
authors.affiliation: Division of Imaging Sciences, St. Thomas' Hospital, King's College London, London, UK.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Rinaldi
authors.affiliation: Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), Kaiserstr. 12, 76131, Karlsruhe, Germany.
authors.forename: Olaf
authors.initials: O
authors.lastname: Dössel
mesh_terms: D018780:Body Surface Potential Mapping / Q000379:methods; D017115:Catheter Ablation / Q000379:methods; D022062:Electrophysiologic Techniques, Cardiac / Q000379:methods; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D017180:Tachycardia, Ventricular / Q000175:diagnosis* / Q000503:physiopathology*; D013909:Thorax / Q000502:physiology
keywords: Clinical validation; ECG imaging; Inverse problem of ECG; Non-contact mapping; Ventricular tachycardia