title: Clinical Application of a Modular Genomics Technique in Systemic Lupus Erythematosus: Progress towards Precision Medicine.
abstract: Monitoring disease activity in a complex, heterogeneous disease such as lupus is difficult. Both over- and undertreatment lead to damage. Current standard of care serologies are unreliable. Better measures of disease activity are necessary as we move into the era of precision medicine. We show here the use of a data-driven, modular approach to genomic biomarker development within lupus-specifically lupus nephritis.
authors.affiliation: Division of Rheumatology, Medical University of South Carolina, Charleston, SC 29425, USA.
authors.forename: Eric
authors.identifier: 0000-0003-0017-9250
authors.initials: E
authors.lastname: Zollars
authors.affiliation: Center for Genomic Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
authors.forename: Sean M
authors.identifier: 0000-0002-6048-5949
authors.initials: SM
authors.lastname: Courtney
authors.affiliation: Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC 29425, USA.
authors.forename: Bethany J
authors.initials: BJ
authors.lastname: Wolf
authors.affiliation: Biogen Idec, Cambridge, MA 02142, USA.
authors.forename: Norm
authors.initials: N
authors.lastname: Allaire
authors.affiliation: Biogen Idec, Cambridge, MA 02142, USA.
authors.forename: Ann
authors.initials: A
authors.lastname: Ranger
authors.affiliation: Center for Genomic Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
authors.forename: Gary
authors.initials: G
authors.lastname: Hardiman
authors.affiliation: Division of Rheumatology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
authors.forename: Michelle
authors.initials: M
authors.lastname: Petri