title: Rab11 and phosphoinositides: A synergy of signal transducers in the control of vesicular trafficking.
abstract: Rab11 and phosphoinositides are signal transducers able to direct the delivery of membrane components to the cell surface. Rab11 is a small GTPase that, by cycling from an active to an inactive state, controls key events of vesicular transport, while phosphoinositides are major determinants of membrane identity, modulating compartmentalized small GTPase function. By sharing common effectors, these two signal transducers synergistically direct vesicular traffic to specific intracellular membranes. This review focuses on the latest advances regarding the mechanisms that ensure the compartmentalized regulation of Rab11 function through its interaction with phosphoinositides.
authors.affiliation: Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center (MBC), University of Torino, Via Nizza 52, 10126 Torino, Italy.
authors.forename: Carlo Cosimo
authors.initials: CC
authors.lastname: Campa
authors.affiliation: Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center (MBC), University of Torino, Via Nizza 52, 10126 Torino, Italy. Electronic address: emilio.hirsch@unito.it.
authors.forename: Emilio
authors.initials: E
authors.lastname: Hirsch
mesh_terms: D000818:Animals; D001692:Biological Transport; D022162:Cytoplasmic Vesicles / Q000378:metabolism*; D020690:GTPase-Activating Proteins / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics / Q000378:metabolism*; D006153:Guanosine Diphosphate / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000378:metabolism; D006801:Humans; D010716:Phosphatidylinositols / Q000378:metabolism*; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D020691:rab GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D000099193:rab11 GTP-Binding Proteins
chemical_list: D020690:GTPase-Activating Proteins; D020662:Guanine Nucleotide Exchange Factors; D006153:Guanosine Diphosphate; D006160:Guanosine Triphosphate; D010716:Phosphatidylinositols; D020033:Protein Isoforms; D020691:rab GTP-Binding Proteins; D000099193:rab11 GTP-Binding Proteins