title: Dietary total antioxidant capacity as a tool in health outcomes in middle-aged and older adults: A systematic review.
abstract: The dietary total antioxidant capacity (TAC) has been a useful tool in epidemiological studies. To assess whether the TAC is associated with chronic diseases in middle-aged and older adults carried out a systematic review of articles indexed in MEDLINE and Science Direct. Of the 104 articles found, nine were included to meet the inclusion criteria. There was variation among the items on the sample size, sample origin, use of statistical tests, analysis of different outcomes and the use of assays to evaluate the TAC, which brought limitations to the comparability of results on the association of TAC with the outcomes of interest. However, in six studies we found an inverse association between TAC and the risk of chronic diseases, showing that this method has great potential for clinical applications and public health.
authors.affiliation: a Departament of Nutrition and Health , Universidade Federal de Vicosa , Vicosa , Brazil.
authors.forename: Mary Anne
authors.identifier: http://orcid.org/0000-0002-3525-6554
authors.initials: MA
authors.lastname: Nascimento-Souza
authors.affiliation: b Department of Chemical Engineering , Universidade Federal de Minas Gerais , Belo Horizonte , Brazil.
authors.forename: Pedro Gontijo
authors.identifier: http://orcid.org/0000-0003-1177-8849
authors.initials: PG
authors.lastname: Paiva
authors.affiliation: c Department of Nutrition and Health , Universidade Federal de Vicosa , Vicosa , Brazil.
authors.forename: Hércia Stampini Duarte
authors.initials: HSD
authors.lastname: Martino
authors.affiliation: c Department of Nutrition and Health , Universidade Federal de Vicosa , Vicosa , Brazil.
authors.forename: Andréia Queiroz
authors.identifier: http://orcid.org/0000-0001-6546-1252
authors.initials: AQ
authors.lastname: Ribeiro
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D016208:Databases, Factual; D004032:Diet; D015438:Health Behavior; D006801:Humans; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D064887:Observational Studies as Topic; D011634:Public Health; D026361:Reactive Nitrogen Species / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000975:Antioxidants; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species
keywords: Total antioxidant capacity; aging; antioxidant; chronic disease; elderly nutrition