title: Effect of wire fretting on the corrosion resistance of common medical alloys.
abstract: Metallic medical devices such as intravascular stents can undergo fretting damage in vivo that might increase their susceptibility to pitting corrosion. As a result, the US Food and Drug Administration has recommended that such devices be evaluated for corrosion resistance after the devices have been fatigue tested in situations where significant micromotion can lead to fretting damage. Three common alloys that cardiovascular implants are made from [MP35N cobalt chromium (MP35N), electropolished nitinol (EP NiTi), and 316LVM stainless steel (316LVM)] were selected for this study. In order to evaluate the effect of wire fretting on the pitting corrosion susceptibility of these medical alloys, small and large fretting scar conditions of each alloy fretting against itself, and the other alloys in phosphate buffered saline (PBS) at 37°C were tested per ASTM F2129 and compared against as received or PBS immersed control specimens. Although the general trend observed was that fretting damage significantly lowered the rest potential (Er) of these specimens (p < 0.01), fretting damage had no significant effect on the breakdown potential (Eb, p > 0.05) and hence did not affect the susceptibility to pitting corrosion. In summary, our results demonstrate that fretting damage in PBS alone is not sufficient to cause increased susceptibility to pitting corrosion in the three common alloys investigated. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2487-2494, 2017.
authors.affiliation: US Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Division of Applied Mechanics, Silver Spring, MD.|Oak Ridge Institute for Science and Education, Oak Ridge, TN.
authors.forename: Danyal A
authors.initials: DA
authors.lastname: Siddiqui
authors.affiliation: US Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Division of Applied Mechanics, Silver Spring, MD.|Oak Ridge Institute for Science and Education, Oak Ridge, TN.
authors.forename: Shiril
authors.initials: S
authors.lastname: Sivan
authors.affiliation: US Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Division of Applied Mechanics, Silver Spring, MD.
authors.forename: Jason D
authors.initials: JD
authors.lastname: Weaver
authors.affiliation: US Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Division of Applied Mechanics, Silver Spring, MD.
authors.forename: Matthew
authors.initials: M
authors.lastname: Di Prima
mesh_terms: D000497:Alloys / Q000737:chemistry*; D001864:Bone Wires; D003343:Corrosion; D008422:Materials Testing
chemical_list: D000497:Alloys
keywords: corrosion; fretting; medical device