title: Sentinel Lymph Node Detection by Blue Dye Versus Indocyanine Green Fluorescence Imaging in Colon Cancer.
abstract: Nodal staging is used in colorectal cancer (CRC) to determine which patients should receive adjuvant chemotherapy. The aim of this study was to evaluate the role of indocyanine green fluorescence imaging (ICG-FI) in sentinel lymph node (SLN) detection compared to the standard technique.
  
  
  
  Twenty patients with CRC admitted for elective colectomy were included (NCT01995591). Ex vivo SLN detection was performed using patent blue (PB) and free ICG injected around the tumor.
  
  
  
  Identification rates were 95% (19/20) for both techniques. Sensitivity was 43% for PB and 57% for ICG. Correlation between the techniques was 83%. FI was more sensitive in patients with body mass index (BMI) >25 kg/m(2) Serial section analysis did not allow for up-staging of patients.
  
  
  
  The use of ICG-FI is superior to the blue dye technique in patients with a BMI >25 kg/m(2) However, the sensitivity of ICG-FI in SLN detection remains low, with a high rate of false-negative results.
authors.affiliation: Department of Surgical Oncology, Jules Bordet Institute, Free University of Brussels, Brussels, Belgium Gabriel.liberale@bordet.be.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Liberale
authors.affiliation: Department of Nuclear Medicine and Clinic-Unit of Lymphology, Jules Bordet Institute, Free University of Brussels, Brussels, Belgium.
authors.forename: Sophie
authors.initials: S
authors.lastname: Vankerckhove
authors.affiliation: Department of Pathology, Jules Bordet Institute, Free University of Brussels, Brussels, Belgium.
authors.forename: Maria Gomez
authors.initials: MG
authors.lastname: Galdon
authors.affiliation: Department of Pathology, Jules Bordet Institute, Free University of Brussels, Brussels, Belgium.
authors.forename: Denis
authors.initials: D
authors.lastname: Larsimont
authors.affiliation: Department of Nuclear Medicine and Clinic-Unit of Lymphology, Jules Bordet Institute, Free University of Brussels, Brussels, Belgium.
authors.forename: Bissan
authors.initials: B
authors.lastname: Ahmed
authors.affiliation: Department of Surgical Oncology, Jules Bordet Institute, Free University of Brussels, Brussels, Belgium.
authors.forename: Fikri
authors.initials: F
authors.lastname: Bouazza
authors.affiliation: Data Centre and Department of Statistics, Jules Bordet Institute, Free University of Brussels, Brussels, Belgium.
authors.forename: Michel
authors.initials: M
authors.lastname: Moreau
authors.affiliation: Department of Surgical Oncology, Jules Bordet Institute, Free University of Brussels, Brussels, Belgium.
authors.forename: Issam
authors.initials: I
authors.lastname: El Nakadi
authors.affiliation: Department of Surgical Oncology, Jules Bordet Institute, Free University of Brussels, Brussels, Belgium.
authors.forename: Vincent
authors.initials: V
authors.lastname: Donckier
authors.affiliation: Department of Nuclear Medicine and Clinic-Unit of Lymphology, Jules Bordet Institute, Free University of Brussels, Brussels, Belgium.
authors.forename: Pierre
authors.initials: P
authors.lastname: Bourgeois
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003110:Colonic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D007208:Indocyanine Green / Q000627:therapeutic use*; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D061848:Optical Imaging; D000071036:Sentinel Lymph Node / Q000000981:diagnostic imaging* / Q000473:pathology
chemical_list: D007208:Indocyanine Green
keywords: Colorectal neoplasms; TNM staging; fluorescence imaging; indocyanine green; lymph node