title: BP Neural Network Could Help Improve Pre-miRNA Identification in Various Species.
abstract: MicroRNAs (miRNAs) are a set of short (21-24 nt) noncoding RNAs that play significant regulatory roles in cells. In the past few years, research on miRNA-related problems has become a hot field of bioinformatics because of miRNAs' essential biological function. miRNA-related bioinformatics analysis is beneficial in several aspects, including the functions of miRNAs and other genes, the regulatory network between miRNAs and their target mRNAs, and even biological evolution. Distinguishing miRNA precursors from other hairpin-like sequences is important and is an essential procedure in detecting novel microRNAs. In this study, we employed backpropagation (BP) neural network together with 98-dimensional novel features for microRNA precursor identification. Results show that the precision and recall of our method are 95.53% and 96.67%, respectively. Results further demonstrate that the total prediction accuracy of our method is nearly 13.17% greater than the state-of-the-art microRNA precursor prediction software tools.
authors.affiliation: School of Computer Science and Technology, Tianjin University, Tianjin 300350, China; School of Information and Electrical Engineering, Hebei University of Engineering, Handan 056038, China.
authors.forename: Limin
authors.initials: L
authors.lastname: Jiang
authors.affiliation: School of Information and Electrical Engineering, Hebei University of Engineering, Handan 056038, China.
authors.forename: Jingjun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: School of Computer Science and Technology, Heilongjiang University, Harbin 150080, China.
authors.forename: Ping
authors.identifier: 0000-0001-5328-691X
authors.initials: P
authors.lastname: Xuan
authors.affiliation: School of Computer Science and Technology, Tianjin University, Tianjin 300350, China; State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300074, China.
authors.forename: Quan
authors.identifier: 0000-0001-6406-1142
authors.initials: Q
authors.lastname: Zou
mesh_terms: D000465:Algorithms; D000818:Animals; D001483:Base Sequence; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D008969:Molecular Sequence Data; D016571:Neural Networks, Computer; D010363:Pattern Recognition, Automated / Q000379:methods*; D012322:RNA Precursors / Q000235:genetics*; D017423:Sequence Analysis, RNA / Q000379:methods*; D012984:Software; D013045:Species Specificity
chemical_list: D035683:MicroRNAs; D012322:RNA Precursors