title: Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?
abstract: In recent years there has been a growing interest among cancer biologists in cancer metabolism. This Review summarizes past and recent advances in our understanding of the reprogramming of glucose metabolism in cancer cells, which is mediated by oncogenic drivers and by the undifferentiated character of cancer cells. The reprogrammed glucose metabolism in cancer cells is required to fulfil anabolic demands. This Review discusses the possibility of exploiting the reprogrammed glucose metabolism for therapeutic approaches that selectively target cancer cells.
authors.affiliation: Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607 and Research and Development Section, Jesse Brown VA Medical Center, Chicago, Illinois 60612, USA.
authors.forename: Nissim
authors.initials: N
authors.lastname: Hay
mesh_terms: D004734:Energy Metabolism; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000628:therapy*
chemical_list: D005947:Glucose