title: Serum Soluble Corin Deficiency Predicts Major Disability within 3 Months after Acute Stroke.
abstract: OBJECTIVE
  Serum soluble corin has been associated with stroke. However, whether it is associated with stroke prognosis has not yet been studied. Therefore, we aimed to study the association of serum soluble corin with risk of poor outcomes within 3 months after stroke.
  
  
  METHODS
  We followed 522 stroke patients for 3 months to identify major disability, death and vascular events. Serum soluble corin was measured at baseline for all participants. Logistic regression was used to examine the associations of baseline serum soluble corin with outcomes of stroke, adjusting for age, sex, baseline NIHSS score, hours from onset to hospitalization, smoking, drinking, hypertension, diabetes, coronary heart disease, atrial fibrillation, family history of stroke, and stroke subtype.
  
  
  RESULTS
  Patients with high corin had a significantly lower crude risk for the composite outcome of major disability or death (OR = 0.64, 95%CI: 0.43-0.96) than patients with low corin (the lowest tertile). After adjustment for age and baseline NIHSS score, patients with high corin still had a significantly lower risk for the composite outcome of major disability or death (OR = 0.60, 95%CI: 0.36-0.99). This association became bottom line significant after additionally adjusting for other conventional factors (OR = 0.61, P = 0.058). No association was found between serum soluble corin and other composite outcomes.
  
  
  CONCLUSIONS
  Serum soluble corin deficiency predicted risk for major disability within 3 months after stroke, independent of baseline neurological deficient. Our results may indicate a probable role of corin in stroke prognosis.
authors.affiliation: Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Hu
authors.affiliation: School of Nursing, Medical College of Soochow University, Suzhou, China.
authors.forename: Shi
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Neurology, Anshan Changda Hospital, Anshan, China.
authors.forename: Yulin
authors.initials: Y
authors.lastname: Song
authors.affiliation: Department of Emergency, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
authors.forename: Fangfang
authors.initials: F
authors.lastname: Zhu
authors.affiliation: Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Jijun
authors.initials: J
authors.lastname: Shi
authors.affiliation: Department of Neurology, Anshan Changda Hospital, Anshan, China.
authors.forename: Xiujie
authors.initials: X
authors.lastname: Han
authors.affiliation: Department of Neurology, Anshan Changda Hospital, Anshan, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Zhou
authors.affiliation: Department of Emergency, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
authors.forename: Zhongwen
authors.initials: Z
authors.lastname: Zhi
authors.affiliation: Department of Neurology, Anshan Changda Hospital, Anshan, China.
authors.forename: Fuding
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Emergency, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou, China.|Institute of Neuroscience, Soochow University, Suzhou, China.
authors.forename: Chun-Feng
authors.initials: CF
authors.lastname: Liu
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.
authors.forename: Hao
authors.identifier: http://orcid.org/0000-0001-6277-662X
authors.initials: H
authors.lastname: Peng