title: Biomarkers of migraine: Part 1 - Genetic markers.
abstract: BACKGROUND
  Migraine is a multifactorial socially significant disease affecting the peripheral and central nervous system. The diagnosis of "migraine" is still the only clinical, and additional methods of inspection are only required to avoid secondary headaches if certain "signs of danger". Accordingly, the search for biomarkers of migraine, confirming the diagnosis, rather than refuting others, is the leading vector in this scientific field.
  
  
  OBJECTIVE
  In this paper we have analyzed the literature data on the genetic markers associated with migraine.
  
  
  METHODS
  List of genes was compiled using Pathway Studio 10® software and abstract database ResNet12 ® made by Elsevier. Addition search (last time on 15 March 2016) was performed by using PubMed or TargetInsights. Information about 185 polymorphic loci in 98 genes associated with migraine was extracted and described.
  
  
  RESULTS
  The genes associated with migraine could be classified into 8 major groups: homeostasis of blood vessels - 26.5%, metabolism of neurotransmitters - 11.2%, transport and reception of neurotransmitters - 24.5%, neurogenesis - 5.1%, inflammation - 8.2%, sex hormones - 5.1%, ion channels and membrane potential - 11.2%, other - 8.2%.
  
  
  CONCLUSIONS
  These findings parallel the range of mechanisms implicated in migraine pathogenesis.
authors.affiliation: Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia.
authors.forename: Natalia
authors.initials: N
authors.lastname: Kondratieva
authors.affiliation: University Headache Clinic, Moscow, Russia.
authors.forename: Julia
authors.initials: J
authors.lastname: Azimova
authors.affiliation: University Headache Clinic, Moscow, Russia.
authors.forename: Kirill
authors.initials: K
authors.lastname: Skorobogatykh
authors.affiliation: University Headache Clinic, Moscow, Russia; Department of Neuroscience, Scientific-Research Centre, Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: Alexey
authors.initials: A
authors.lastname: Sergeev
authors.affiliation: Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia; University Headache Clinic, Moscow, Russia.
authors.forename: Elena
authors.initials: E
authors.lastname: Naumova
authors.affiliation: Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia.
authors.forename: Zarema
authors.initials: Z
authors.lastname: Kokaeva
authors.affiliation: Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia.
authors.forename: Arina
authors.initials: A
authors.lastname: Anuchina
authors.affiliation: Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia.
authors.forename: Olga
authors.initials: O
authors.lastname: Rudko
authors.affiliation: University Headache Clinic, Moscow, Russia; Department of Neuroscience, Scientific-Research Centre, Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: Gyuzyal
authors.initials: G
authors.lastname: Tabeeva
authors.affiliation: Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia; University Diagnostic Laboratory, Moscow, Russia. Electronic address: klimov_eugeney@mail.ru.
authors.forename: Eugene
authors.initials: E
authors.lastname: Klimov
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008881:Migraine Disorders / Q000175:diagnosis* / Q000235:genetics*
chemical_list: D015415:Biomarkers
keywords: Gene; Genetic association; Genetic polymorphism; Migraine