title: Production and purification of Scandium-47: A potential radioisotope for cancer theranostics.
abstract: In this study, production of47Sc radionuclide by irradiating the natural titanium dioxide powder (TiO2) in the fast neutron flux (~3*1013ncm-2s-1) for 4 days in Tehran Research Reactor (TRR, Iran) and separation from titanium target was investigated. The study showed the feasibility of production47Sc by TRR. The separation efficiency and radiochemical purity (ScCl3) of radio-scandium,47Sc radionuclide purity were obtained 98%, 99% and 88% respectively.
authors.affiliation: Department of Medical Radiation Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Leila
authors.initials: L
authors.lastname: Deilami-Nezhad
authors.affiliation: Radiopharmaceutical Research and Development Lab, Nuclear Science and Technology Institute, P.O. Box: 14155-1339, Tehran, Iran.
authors.forename: Leila
authors.initials: L
authors.lastname: Moghaddam-Banaem
authors.affiliation: Radiation Application Research School, Nuclear Science and Technology Research Institute, P.O. Box: 14395-836, Tehran, Iran. Electronic address: msadeghi@nrcam.org.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Sadeghi
authors.affiliation: Radiopharmaceutical Research and Development Lab, Nuclear Science and Technology Institute, P.O. Box: 14155-1339, Tehran, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Asgari
mesh_terms: D006801:Humans; D007553:Isotope Labeling / Q000379:methods*; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D011868:Radioisotopes / Q000737:chemistry* / Q000302:isolation & purification* / Q000627:therapeutic use; D019275:Radiopharmaceuticals / Q000302:isolation & purification* / Q000627:therapeutic use*; D012538:Scandium / Q000737:chemistry* / Q000302:isolation & purification* / Q000627:therapeutic use; D000068936:Theranostic Nanomedicine / Q000379:methods
chemical_list: D011868:Radioisotopes; D019275:Radiopharmaceuticals; C000615359:Scandium-47; D012538:Scandium
keywords: Cation exchange chromatography; Natural titanium; Reactor production; Scandium-47