title: Two-Step Route to Diverse N-Functionalized Peptidomimetic-like Isatins through an Oxidation/Intramolecular Oxidative-Amidation Cascade of Ugi Azide and Ugi Three-Component Reaction Products.
abstract: Two-step methodology described herein showcases the first example of an oxidation/oxidative amidation cyclization cascade of MCR products toward diverse N-functionalized isatins. Products of both the Ugi 3CR and the Ugi azide reactions are oxidatively cyclized through a postcondensation process utilizing selenium dioxide. This methodology was found to be applicable for the generation of bis-peptidomimetic-like isatins containing multiple points of diversification.
authors.affiliation: Department of Chemistry and Biochemistry, College of Science and ‡Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona , Tucson, Arizona 85721, United States.
authors.forename: Christopher
authors.initials: C
authors.lastname: Foley
authors.affiliation: Department of Chemistry and Biochemistry, College of Science and ‡Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona , Tucson, Arizona 85721, United States.
authors.forename: Arthur
authors.initials: A
authors.lastname: Shaw
authors.affiliation: Department of Chemistry and Biochemistry, College of Science and ‡Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona , Tucson, Arizona 85721, United States.
authors.forename: Christopher
authors.initials: C
authors.lastname: Hulme