title: Genotypic distribution of single nucleotide polymorphisms in oral cancer: global scene.
abstract: Globocan 2012 reports the global oral cancer incidence of 300,373 new oral cancer cases annually, contributing to 2.1 % of the world cancer burden. The major well-established risk factors for oral cancer include tobacco, betel/areca nut, alcohol and high-risk oncogenic human papilloma virus (HPV) 16/18. However, only 5-10 % of individuals with high-risk lifestyle develop oral cancer. Thus, genomic variants in individuals represented as single nucleotide polymorphisms (SNPs) influence susceptibility to oral cancer. With a view to understanding the role of genomic variants in oral cancer, we reviewed SNPs in case-control studies with a minimum of 100 cases and 100 controls. PubMed and HuGE navigator search engines were used to obtain data published from 1990 to 2015, which identified 67 articles investigating the role of SNPs in oral cancer. Single publications reported 93 SNPs in 55 genes, with 34 SNPs associated with a risk of oral cancer. Meta-analysis of data in multiple studies defined nine SNPs associated with a risk of oral cancer. The genes were associated with critical functions deregulated in cancers, including cell proliferation, immune function, inflammation, transcription, DNA repair and xenobiotic metabolism.
authors.affiliation: Department of Biological Sciences, Sunandan Divatia School of Science, NMIMS (Deemed-to-be) University, Mumbai, Maharashtra, 400056, India.
authors.forename: Shaleen
authors.initials: S
authors.lastname: Multani
authors.affiliation: Department of Biological Sciences, Sunandan Divatia School of Science, NMIMS (Deemed-to-be) University, Mumbai, Maharashtra, 400056, India. dhananjaya.saranath@nmims.edu.
authors.forename: Dhananjaya
authors.initials: D
authors.lastname: Saranath
mesh_terms: D001114:Areca / Q000009:adverse effects; D049109:Cell Proliferation / Q000235:genetics; D004260:DNA Repair / Q000235:genetics; D000431:Ethanol / Q000009:adverse effects; D020022:Genetic Predisposition to Disease; D006801:Humans; D007249:Inflammation / Q000235:genetics; D009062:Mouth Neoplasms / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D014026:Nicotiana / Q000009:adverse effects
chemical_list: D000431:Ethanol
keywords: Genomic variants; Meta-analysis; Oral cancer; Risk; Single nucleotide polymorphisms; Susceptibility