title: 18F-NaF and 18F-FDG PET/CT in Gorham-Stout Disease.
abstract: Gorham-Stout disease (GSD) is an extremely rare skeletal disorder of unknown etiology characterized by benign proliferation of vascular or lymphatic channels, leading to progressive bone resorption. We report on a patient diagnosed with GSD affecting the right scapula and the right ribs, who underwent PET/CT scans using F-FDG and F-NaF. The remnant upper portion of the affected scapula did not show F-FDG uptake but demonstrated markedly increased F-NaF activity. Furthermore, intense F-NaF activity was seen on the right posterior ribs, which were actively being resorbed, suggesting the potential application of F-NaF-PET/CT imaging in GSD diagnosis and follow-up.
authors.affiliation: From the *Radiology and Imaging Sciences, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda; †Division of Nuclear Medicine, RAD&IS, Clinical Center, National Institutes of Health, Bethesda, MD; ‡Center for Research in Computer Vision, Electrical and Computer Science Department, University of Central Florida, Orlando, FL; §National Institute of Child Health and Human Development, National Institutes of Health, Bethesda; and ∥Craniofacial and Skeletal Diseases Branch, National Institutes of Dental and Craniofacial Research, Bethesda, MD.
authors.forename: Georgios Z
authors.initials: GZ
authors.lastname: Papadakis
authors.forename: Corina
authors.initials: C
authors.lastname: Millo
authors.forename: Ulas
authors.initials: U
authors.lastname: Bagci
authors.forename: Jenny
authors.initials: J
authors.lastname: Blau
authors.forename: Michael T
authors.initials: MT
authors.lastname: Collins
mesh_terms: D000328:Adult; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D010015:Osteolysis, Essential / Q000000981:diagnostic imaging*; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals; D012969:Sodium Fluoride
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D012969:Sodium Fluoride