title: Takotsubo Syndrome: Insights from Japan.
abstract: We report the history and new insights of takotsubo syndrome based on the achievements that Japanese researchers have contributed and summarize the evidence originally presented from Japan. Takotsubo syndrome is a newly described heart failure characterized by transient left ventricular dysfunction. We should be aware of this entity as a syndrome, not actual cardiomyopathy. Japanese researchers focus on the experimental approaches for clinical diagnosis and treatment of takotsubo syndrome. As representatives from a country originally naming this syndrome takotsubo, a global registry for takotsubo syndrome including Japan should be established.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao Miyamae-ku, Kawasaki, Kanagawa, 216-8511, Japan. Electronic address: yoakashi-circ@umin.ac.jp.
authors.forename: Yoshihiro J
authors.initials: YJ
authors.lastname: Akashi
authors.affiliation: Division of Coronary Artery Disease, Department of Internal Medicine, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan.
authors.forename: Masaharu
authors.initials: M
authors.lastname: Ishihara
mesh_terms: D019468:Disease Management; D005260:Female; D049673:History, 20th Century; D006801:Humans; D007564:Japan; D008297:Male; D012042:Registries; D013312:Stress, Physiological; D013315:Stress, Psychological / Q000503:physiopathology; D054549:Takotsubo Cardiomyopathy / Q000209:etiology / Q000266:history* / Q000523:psychology / Q000628:therapy*
keywords: Apical ballooning; Autonomic nervous; Catecholamine; Estrogen; Heart failure; Stress