title: [Chemotherapy-induced amenorrhea in moroccan population: a retrospective cohort study].
abstract: BACKGROUND
  Breast cancer is one of the most common cancers in premenopausal women and its treatment may affect their fertility. Indeed, chemotherapy used in breast cancer may cause transient or permanent amenorrhea in premenopausal women.
  
  
  METHODS
  We conducted a retrospective study of young patients with localized breast canceri in the Department of Medical Oncology, Mohammed VI Inuversity Hospital, Oujda, Morocco over a 3-year period from January 2009 to December 2011. The aim of our study was to analyse the impact of chemotherapy-induced amenorrhea (CIA) as well as predictive factors for its occurrence.
  
  
  RESULTS
  In our series, 74% of patients had CIA and 33.6% of patients had definitive chemotherapy-induced amenorrhea. Several factors have been studied in search of predictive factors for amenorrhea occurrence. With regard to the age factor, our analysis showed that women over 40 were more likely to have amenorrhea than those aged less than 40 years (95.7% versus 56.1%), with a statistically significant difference (p = 0.003).
  
  
  CONCLUSIONS
  In our study the incidence of ICA seems comparable to that found in the literature, while age is the predominant predictor of its occurrence.
authors.affiliation: Service d'Oncologie Médicale, Centre Hospitalier Mohammed VI, Oujda, Maroc.
authors.forename: Sami Aziz
authors.initials: SA
authors.lastname: Brahmi
authors.affiliation: Service d'Oncologie Médicale, Centre Hospitalier Hassan II, Fès, Maroc.
authors.forename: Fatima Zahra
authors.initials: FZ
authors.lastname: Ziani
authors.affiliation: Service d'Oncologie Médicale, Centre Hospitalier Mohammed VI, Oujda, Maroc.
authors.forename: Seddik
authors.initials: S
authors.lastname: Youssef
authors.affiliation: Service d'Oncologie Médicale, Centre Hospitalier Mohammed VI, Oujda, Maroc.
authors.forename: Said
authors.initials: S
authors.lastname: Afqir
mesh_terms: D000328:Adult; D000367:Age Factors; D000568:Amenorrhea / Q000139:chemically induced* / Q000453:epidemiology; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D009018:Morocco; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents
keywords: Breast cancer; amenorrhea; chemotherapy