title: Hypophosphatemia-induced Cardiomyopathy.
abstract: Relatively few studies have been conducted to evaluate the effect of hypophosphatemia on cardiac function. The goal of this review was to determine whether there is an association between hypophosphatemia and cardiac function and to increase awareness of hypophosphatemia-induced cardiomyopathy as a new clinical entity and a reversible cause of heart failure. We searched MEDLINE and PubMed from 1971 until March 2015 for primary studies, which reported the relationship between hypophosphatemia and cardiac function. A total of 837 articles were initially obtained. Of these articles, 826 publications were excluded according to the inclusion and exclusion criteria. In all, 11 articles were included in this review. These articles included 7 case series or case reports, 1 case-control study, 1 pretest versus posttest in a single group and 2 animal studies. In conclusion, the mechanisms of hypophosphatemia in cardiomyopathy have been reported to be a depletion of adenosine triphosphate in myocardial cells and decreased 2,3-diphosphoglycerate in erythrocytes. After correction of hypophosphatemia, left ventricular performance seems to improve in patients with severe hypophosphatemia, but not in those with mild-to-moderate hypophosphatemia. However, analyses of the relationship between cardiac function and hypophosphatemia using clinical end points have not been conducted.
authors.affiliation: Department of Internal Medicine, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii. Electronic address: na39@hawaii.edu.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Ariyoshi
authors.affiliation: Department of Internal Medicine, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Nogi
authors.affiliation: Department of Internal Medicine, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii.
authors.forename: Akika
authors.initials: A
authors.lastname: Ando
authors.affiliation: Department of Internal Medicine, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Watanabe
authors.affiliation: Department of Internal Medicine, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii.
authors.forename: Sari
authors.initials: S
authors.lastname: Umekawa
mesh_terms: D019794:2,3-Diphosphoglycerate / Q000097:blood; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D009202:Cardiomyopathies / Q000097:blood / Q000209:etiology*; D006321:Heart / Q000503:physiopathology; D006334:Heart Function Tests; D006801:Humans; D017674:Hypophosphatemia / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D010710:Phosphates / Q000097:blood; D012720:Severity of Illness Index
chemical_list: D010710:Phosphates; D019794:2,3-Diphosphoglycerate; D000255:Adenosine Triphosphate
keywords: Cardiomyopathy; Heart failure; Hypophosphatemia