title: Advanced computational workflow for the multi-scale modeling of the bone metabolic processes.
abstract: Multi-scale modeling of the musculoskeletal system plays an essential role in the deep understanding of complex mechanisms underlying the biological phenomena and processes such as bone metabolic processes. Current multi-scale models suffer from the isolation of sub-models at each anatomical scale. The objective of this present work was to develop a new fully integrated computational workflow for simulating bone metabolic processes at multi-scale levels. Organ-level model employs multi-body dynamics to estimate body boundary and loading conditions from body kinematics. Tissue-level model uses finite element method to estimate the tissue deformation and mechanical loading under body loading conditions. Finally, cell-level model includes bone remodeling mechanism through an agent-based simulation under tissue loading. A case study on the bone remodeling process located on the human jaw was performed and presented. The developed multi-scale model of the human jaw was validated using the literature-based data at each anatomical level. Simulation outcomes fall within the literature-based ranges of values for estimated muscle force, tissue loading and cell dynamics during bone remodeling process. This study opens perspectives for accurately simulating bone metabolic processes using a fully integrated computational workflow leading to a better understanding of the musculoskeletal system function from multiple length scales as well as to provide new informative data for clinical decision support and industrial applications.
authors.affiliation: Sorbonne University, Université de Technologie de Compiègne, CNRS, UMR 7338 Biomechanics and Bioengineering, Centre de recherche Royallieu, CS 60 319, 60203, Compiègne Cedex, France. tien-tuan.dao@utc.fr.
authors.forename: Tien Tuan
authors.initials: TT
authors.lastname: Dao
mesh_terms: D001696:Biomechanical Phenomena / Q000502:physiology; D016723:Bone Remodeling / Q000502:physiology; D001842:Bone and Bones / Q000378:metabolism* / Q000502:physiology*; D003198:Computer Simulation; D006801:Humans; D013314:Stress, Mechanical; D057188:Workflow
keywords: Agent-based modeling; Bone metabolic processes; Bone remodeling; Finite element modeling; Fully integrated computational workflow; Multi-scale modeling; Musculoskeletal system; Rigid body modeling