title: A case of tophaceous pseudogout of the temporomandibular joint extending to the base of the skull.
abstract: A case of tophaceous pseudogout (i.e., calcium pyrophosphate dihydrate (CPPD) crystal deposition disease) in the temporomandibular joint (TMJ), extending to the base of the skull, is reported. A 38-year-old man was referred to the hospital with mild pain in the right chin and tip of the tongue. Panoramic radiography showed a large calcified mass around the right TMJ. Computed tomography imaging revealed a large, granular, calcified mass surrounding the right condylar head and extending to the base of the skull. The mass was clinically and radiographically suspected to be a pseudogout lesion. A biopsy specimen was collected under general anaesthesia to confirm the diagnosis. On histology, the mass was found to contain deposits of numerous rod-shaped and rhomboid crystals, which suggested tophaceous pseudogout. The deposits were identified as CPPD crystal deposition, based on analysis by X-ray diffraction and Fourier transform infrared spectroscopy. These two crystallography methods were useful in confirming the diagnosis of CPPD crystal deposition disease in the TMJ.
authors.affiliation: Department of Oral Surgery, Subdivision of Molecular Oral Medicine, Division of Integrated Sciences of Translational Research, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan. Electronic address: kkudoh@tokushima-u.ac.jp.
authors.forename: K
authors.initials: K
authors.lastname: Kudoh
authors.affiliation: Department of Oral Surgery, Subdivision of Molecular Oral Medicine, Division of Integrated Sciences of Translational Research, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kudoh
authors.affiliation: Department of Biomaterials, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tsuru
authors.affiliation: Department of Oral Surgery, Subdivision of Molecular Oral Medicine, Division of Integrated Sciences of Translational Research, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Miyamoto
mesh_terms: D000328:Adult; D001706:Biopsy; D002805:Chondrocalcinosis / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D011862:Radiography, Panoramic; D017550:Spectroscopy, Fourier Transform Infrared; D013705:Temporomandibular Joint Disorders / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed; D014961:X-Ray Diffraction
keywords: Fourier transform infrared spectroscopy; X-ray diffraction; calcium pyrophosphate dihydrate; temporomandibular joint; tophaceous pseudogout