title: Nationwide Surveillance of Novel Oxazolidinone Resistance Gene optrA in Enterococcus Isolates in China from 2004 to 2014.
abstract: A total of 2,201 nonduplicate enterococcal isolates collected from 29 hospitals in 23 cities in China between 2004 and 2014 were screened for the oxazolidinone resistance gene optrA; 45 isolates (2.0%) were optrA positive with 11 OptrA variants identified. The positive rate of optrA increased from 0.4% to 3.9% during the 10-year surveillance period. Pulsed-field gel electrophoresis (PFGE) and multilocus sequence type (MLST) analysis revealed that 37 optrA-positive Enterococcus faecalis isolates clustered into 25 PFGE patterns and 21 sequence types, while 6 Enterococcus faecium isolates represented 6 PFGE patterns and 6 sequence types. The present study underscores the importance of routine and persistent monitoring of oxazolidinone resistance and optrA gene.
authors.affiliation: Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China.
authors.forename: Lanqing
authors.initials: L
authors.lastname: Cui
authors.affiliation: Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China lvyuan0901@sina.com.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Lv
authors.affiliation: Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Wang
authors.affiliation: Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China.
authors.forename: Yunjia
authors.initials: Y
authors.lastname: Song
authors.affiliation: Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Li
authors.affiliation: Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.affiliation: Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Xue
authors.affiliation: Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Yang
authors.affiliation: Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002681:China / Q000453:epidemiology; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D016521:Electrophoresis, Gel, Pulsed-Field; D013293:Enterococcus faecalis / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development / Q000302:isolation & purification; D016984:Enterococcus faecium / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development / Q000302:isolation & purification; D005798:Genes, Bacterial; D005838:Genotype; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D058885:Multilocus Sequence Typing; D009154:Mutation; D023303:Oxazolidinones / Q000494:pharmacology; D062486:Public Health Surveillance
chemical_list: D000900:Anti-Bacterial Agents; D023303:Oxazolidinones