title: CEACAM1: Expression and Role in Melanocyte Transformation.
abstract: Metastases represent the main cause of death in melanoma patients. Despite the current optimized targeted therapy or immune checkpoint inhibitors the treatment of metastatic melanoma is unsatisfactory. Because of the poor prognosis of advanced melanoma there is an urgent need to identify new biomarkers to differentiate melanoma cells from normal melanocytes, to stratify patients according to their risk, and to identify subgroups of patients that require close follow-up or more aggressive therapy. Furthermore, melanoma progression has been associated with the dysregulation of cell adhesion molecules. We have reviewed the literature and have discussed the important role of the expression of the carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) in the development of melanoma. Thus, novel insights into CEACAM1 may lead to promising strategies in melanoma treatment, in monitoring melanoma patients, in assessing the response to immunotherapy, and in completing the standard immunohistochemical panel used in melanoma examination.
authors.affiliation: Colentina Clinical Hospital, 1st Dermatology Department, "Carol Davila" University of Medicine and Pharmacy, 020125 Bucharest, Romania.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Turcu
authors.affiliation: Department of Pathophysiology II, Clinical Department No. 2, "Carol Davila" University of Medicine and Pharmacy, 021105 Bucharest, Romania.
authors.forename: Roxana Ioana
authors.identifier: 0000-0001-7071-527X
authors.initials: RI
authors.lastname: Nedelcu
authors.affiliation: Department of Pathophysiology II, Clinical Department No. 2, "Carol Davila" University of Medicine and Pharmacy, 021105 Bucharest, Romania.
authors.forename: Daniela Adriana
authors.initials: DA
authors.lastname: Ion
authors.affiliation: Department of Pathophysiology II, Clinical Department No. 2, "Carol Davila" University of Medicine and Pharmacy, 021105 Bucharest, Romania.
authors.forename: Alice
authors.initials: A
authors.lastname: Brînzea
authors.affiliation: Pathology Department, Colentina Clinical Hospital, "Carol Davila" University of Medicine and Pharmacy, 020125 Bucharest, Romania.
authors.forename: Mirela Daniela
authors.initials: MD
authors.lastname: Cioplea
authors.affiliation: Department of Medicine, Section of Medical Oncology, Yale University School of Medicine, New Haven, CT 208028, USA.
authors.forename: Lucia Beatrice
authors.initials: LB
authors.lastname: Jilaveanu
authors.affiliation: Pathology Department, Colentina Clinical Hospital, "Carol Davila" University of Medicine and Pharmacy, 020125 Bucharest, Romania.
authors.forename: Sabina Andrada
authors.identifier: 0000-0002-3498-8454
authors.initials: SA
authors.lastname: Zurac
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008544:Melanocytes / Q000378:metabolism / Q000473:pathology*
chemical_list: D015703:Antigens, CD; C069847:CD66 antigens; D015815:Cell Adhesion Molecules