title: Is cerebral glucose metabolism related to blood-brain barrier dysfunction and intrathecal IgG synthesis in Alzheimer disease?: A 18F-FDG PET/CT study.
abstract: The aim of this study was to investigate the relationships between blood-brain barrier (BBB) dysfunction, intrathecal IgG synthesis, and brain glucose consumption as detectable by means of serum/cerebrospinal fluid (CSF) albumin index (Qalb) and IgG index [(CSF IgG/serum IgG) × Serum albumin/CSF albumin)] and 2-deoxy-2-(F) fluoro-D-glucose (F-FDG) positron emission tomography/computed tomography (PET/CT) in a selected population affected by Alzheimer disease (AD). The study included 134 newly diagnosed AD patients according to the NINCDS-ADRDA criteria. The mean (±SD) age of the patients was 70 (±6) years; 60 were male and 64 were female. Mini mental State Examination was equal to 18.9 (±7.2). All patients underwent a CSF assay and magnetic resonance before F-FDG PET scanning. The relationships were evaluated by means of statistical parametric mapping (SPM8). We found a significant negative correlation between the increase of Qalb and F-FDG uptake in the Brodmann Area 42 and 22 that corresponds to the left superior temporal gyrus, with higher Qalb values being related to a reduced glucose consumption in these areas. No significant relationships have been found between brain glucose consumption and IgG index. The results of our study suggest that BBB dysfunction is related to reduction of cortical activity in the left temporal cortex in AD subjects.
authors.affiliation: Department of Biomedicine and Prevention, University Tor Vergata, Rome, Italy IRCCS Neuromed, Pozzilli, Italy Department of Health Sciences, University Magna Graecia, Catanzaro, Italy Department of Neurosciences, University Tor Vergata, Rome, Italy IRCCS Santa Lucia, Rome, Italy.
authors.forename: Agostino
authors.initials: A
authors.lastname: Chiaravalloti
authors.forename: Alessandro
authors.initials: A
authors.lastname: Fiorentini
authors.forename: Ursini
authors.initials: U
authors.lastname: Francesco
authors.forename: Alessandro
authors.initials: A
authors.lastname: Martorana
authors.forename: Giacomo
authors.initials: G
authors.lastname: Koch
authors.forename: Lorena
authors.initials: L
authors.lastname: Belli
authors.forename: Sofia
authors.initials: S
authors.lastname: Toniolo
authors.forename: Barbara
authors.initials: B
authors.lastname: Di Pietro
authors.forename: Caterina
authors.initials: C
authors.lastname: Motta
authors.forename: Orazio
authors.initials: O
authors.lastname: Schillaci
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D001812:Blood-Brain Barrier / Q000503:physiopathology*; D001921:Brain / Q000378:metabolism*; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis*; D008297:Male; D000072078:Positron Emission Tomography Computed Tomography
chemical_list: D007074:Immunoglobulin G; D019788:Fluorodeoxyglucose F18; D005947:Glucose