title: Does IGF-1 play a role in the biology of endometrial cancer?
abstract: Insulin-like growth factor 1 (IGF-1) is a mitogen which plays a key role in regulating cell proliferation, differentiation, and apoptosis. It belongs to the family of proteins also composed of insulin-like growth factor 2 (IGF-2), two types of membrane receptors (IGF-1R and IGF-2R), 6 binding proteins (IGFBP 1-6), hydrolyzing proteases, and reactive molecules binding proteins, which regulate the activity of growth factors. Disturbances in the functioning of IGFBP/IGF/1GF1R can lead to induction of carcinogenesis, which has been demonstrated in breast, prostate or colon cancers. Findings evaluating the role of IGF-1 in endometrial cancer biology are ambiguous and contradictory. Therefore, in the present study, we analyzed the role of IGF-1 in the process of carcinogenesis of endometrial cancer, based on the available literature.
authors.affiliation: Department of Surgical, Endoscopic and Oncologic Gynecology, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland. majchrzak.dominika@gmail.com.
authors.forename: Dominika
authors.initials: D
authors.lastname: Majchrzak-Baczmańska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Malinowski
mesh_terms: D063646:Carcinogenesis; D049109:Cell Proliferation; D016889:Endometrial Neoplasms / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D009389:Neovascularization, Pathologic
chemical_list: D007334:Insulin-Like Growth Factor I
keywords: carcinogenesis; endometrial cancer; insulin-like growth factor-1