title: [Cerebrospinal fluid diagnostics in multiple sclerosis].
abstract: As a chronic inflammatory disease of the central nervous system (CNS), multiple sclerosis (MS) is associated with characteristic abnormalities in cerebrospinal fluid (CSF). Thus, in addition to magnetic resonance imaging, CSF examination is a central diagnostic procedure in patients with MS, which can corroborate a diagnosis of MS and may also help to discern differential diagnoses. The most important CSF finding in MS is the detection of persistent polyspecific intrathecal immunoglobulin synthesis. This review summarizes CSF findings of patients with MS and addresses issues of relevance for clinical practice, potential diagnostic pitfalls as well as new developments in CSF diagnostics of MS.
authors.affiliation: Klinik für Neurologie, Klinisches und Experimentelles Forschungszentrum für Multiple Sklerose, Charité - Universitätsmedizin Berlin, Berlin, Deutschland.
authors.forename: K
authors.initials: K
authors.lastname: Ruprecht
authors.affiliation: Fachklinik für Neurologie Dietenbronn, Dietenbronn 7, 88477, Schwendi, Deutschland. hayrettin.tumani@uni-ulm.de.|Neurologische Universitätsklinik im RKU, Oberer Eselsberg 45, 89081, Ulm, Deutschland. hayrettin.tumani@uni-ulm.de.
authors.forename: H
authors.initials: H
authors.lastname: Tumani
mesh_terms: D015415:Biomarkers / Q000134:cerebrospinal fluid*; D002555:Cerebrospinal Fluid / Q000737:chemistry*; D003943:Diagnostic Techniques, Neurological; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis*; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000175:diagnosis*
chemical_list: D015415:Biomarkers; D007136:Immunoglobulins
keywords: Cerebrospinal fluid; Diagnosis; Differential diagnosis; Immunoglobulins; Oligoclonal bands