title: Effects of antipsychotic drug administration on antioxidative defense enzymes in male rat kidney.
abstract: The use of atypical antipsychotic drugs (APD) was reported to be associated with adverse effects on the kidneys. Thus, the aim of this study was to examine whether APD exerted their adverse effects by interfering with the renal antioxidant defense system. Male 3-mo-old Wistar rats were treated for 28 d with ziprasidone (ZIP), clozapine (CLO), or sertindole (SER) using a daily dose recommended for antipsychotic drug therapy. The expression and activities of antioxidant enzymes superoxide dismutase (SOD) type 1 and type 2, catalase (CAT), glutathione reductase (GR), and glutathione S-transferases (GSTs) activity were measured in the kidneys. Changes in the kidneys were also evaluated histologically. Ziprasidone, CLO, and SER reduced renal SOD type 1 and type 2 activities. Decreased CAT activity was observed only in SER-treated rats. An inhibition in GR activity and increased activity of GST was found only after treatment with CLO. Histological analysis showed dilatation of proximal tubules in kidneys with all three drugs. In conclusion, data indicate that redox disturbances may contribute to renal morphologic alterations in proximal tubules in rats treated with all APD.
authors.affiliation: a Department of Physiology , Institute for Biological Research "Siniša Stanković," University of Belgrade , Belgrade , Serbia.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Nikolić-Kokić
authors.affiliation: a Department of Physiology , Institute for Biological Research "Siniša Stanković," University of Belgrade , Belgrade , Serbia.
authors.forename: Ana
authors.initials: A
authors.lastname: Mijušković
authors.affiliation: a Department of Physiology , Institute for Biological Research "Siniša Stanković," University of Belgrade , Belgrade , Serbia.
authors.forename: Nikola
authors.initials: N
authors.lastname: Tatalović
authors.affiliation: b Department of Biochemistry , Institute for Biological Research "Siniša Stanković," University of Belgrade , Belgrade , Serbia.
authors.forename: Jelena
authors.initials: J
authors.lastname: Nestorov
authors.affiliation: c Department of Cytology , Institute for Biological Research "Siniša Stanković," University of Belgrade , Belgrade , Serbia.
authors.forename: Marko
authors.initials: M
authors.lastname: Miler
authors.affiliation: a Department of Physiology , Institute for Biological Research "Siniša Stanković," University of Belgrade , Belgrade , Serbia.
authors.forename: Zorana
authors.initials: Z
authors.lastname: Oreščanin-Dušić
authors.affiliation: d Department of Biochemistry, Faculty of Chemistry , University of Belgrade , Belgrade , Serbia.
authors.forename: Milan
authors.initials: M
authors.lastname: Nikolić
authors.affiliation: c Department of Cytology , Institute for Biological Research "Siniša Stanković," University of Belgrade , Belgrade , Serbia.
authors.forename: Verica
authors.initials: V
authors.lastname: Milošević
authors.affiliation: a Department of Physiology , Institute for Biological Research "Siniša Stanković," University of Belgrade , Belgrade , Serbia.
authors.forename: Duško
authors.initials: D
authors.lastname: Blagojević
authors.affiliation: a Department of Physiology , Institute for Biological Research "Siniša Stanković," University of Belgrade , Belgrade , Serbia.
authors.forename: Mihajlo
authors.initials: M
authors.lastname: Spasić
authors.affiliation: e Institute of Mental Health, School of Medicine , University of Belgrade , Belgrade , Serbia.
authors.forename: Čedo
authors.initials: Č
authors.lastname: Miljević
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D014150:Antipsychotic Agents / Q000633:toxicity*; D003024:Clozapine / Q000633:toxicity*; D007093:Imidazoles / Q000633:toxicity*; D007211:Indoles / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D010879:Piperazines / Q000633:toxicity*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013844:Thiazoles / Q000633:toxicity*
chemical_list: D000975:Antioxidants; D014150:Antipsychotic Agents; D007093:Imidazoles; D007211:Indoles; D010879:Piperazines; D013844:Thiazoles; C092292:ziprasidone; C066304:sertindole; D003024:Clozapine