title: [Interleukin-1, inflammasome and autoinflammatory diseases].
abstract: Interleukin-1 is a major cytokine of innate immunity and inflammation. It exerts various systemic effects during the inflammatory response, such as fever induction, thrombopoiesis and granulopoiesis, or leukocyte recruitment. Its involvement has been demonstrated in many inflammatory-mediated diseases, such as diabetes or gout. Moreover, interleukin-1 plays a pivotal role in some autoinflammatory diseases, such as cryopyrinopathies or familial Mediterranean fever. In these diseases, a constitutional defect of the inflammasome, a protein complex responsible for the activation of interleukin-1, explains the hypersecretion of interleukin-1. Other autoinflammatory diseases have a more complex pathophysiology involving deregulation of the interleukin-1 pathway, upstream or downstream of the inflammasome, or through more complex mechanisms. In this review, we are detailing the synthesis, the activation, the signalling, and the regulation of interleukin-1. We then describe the autoinflammatory diseases or related-diseases where the pathological role of interleukin-1 has been demonstrated.
authors.affiliation: Service de médecine interne, université Claude-Bernard-Lyon 1, hôpital de la Croix-Rousse, 103, grande rue de la Croix-Rousse, 69004 Lyon, France; Centre international de recherche en infectiologie (CIRI), Inserm U1111, université Lyon 1, 69007 Lyon, France. Electronic address: yvanjamilloux@hotmail.com.
authors.forename: Y
authors.initials: Y
authors.lastname: Jamilloux
authors.affiliation: Centre international de recherche en infectiologie (CIRI), Inserm U1111, université Lyon 1, 69007 Lyon, France.
authors.forename: E
authors.initials: E
authors.lastname: Bourdonnay
authors.affiliation: Service de médecine interne, université Claude-Bernard-Lyon 1, hôpital de la Croix-Rousse, 103, grande rue de la Croix-Rousse, 69004 Lyon, France.
authors.forename: M
authors.initials: M
authors.lastname: Gerfaud-Valentin
authors.affiliation: Centre international de recherche en infectiologie (CIRI), Inserm U1111, université Lyon 1, 69007 Lyon, France.
authors.forename: B F
authors.initials: BF
authors.lastname: Py
authors.affiliation: Centre international de recherche en infectiologie (CIRI), Inserm U1111, université Lyon 1, 69007 Lyon, France.
authors.forename: L
authors.initials: L
authors.lastname: Lefeuvre
authors.affiliation: Service de médecine interne, université Claude-Bernard-Lyon 1, hôpital de la Croix-Rousse, 103, grande rue de la Croix-Rousse, 69004 Lyon, France.
authors.forename: T
authors.initials: T
authors.lastname: Barba
authors.affiliation: Service de médecine interne, université Claude-Bernard-Lyon 1, hôpital de la Croix-Rousse, 103, grande rue de la Croix-Rousse, 69004 Lyon, France.
authors.forename: C
authors.initials: C
authors.lastname: Broussolle
authors.affiliation: Centre international de recherche en infectiologie (CIRI), Inserm U1111, université Lyon 1, 69007 Lyon, France.
authors.forename: T
authors.initials: T
authors.lastname: Henry
authors.affiliation: Service de médecine interne, université Claude-Bernard-Lyon 1, hôpital de la Croix-Rousse, 103, grande rue de la Croix-Rousse, 69004 Lyon, France.
authors.forename: P
authors.initials: P
authors.lastname: Sève
mesh_terms: D020022:Genetic Predisposition to Disease; D056660:Hereditary Autoinflammatory Diseases / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D058847:Inflammasomes / Q000378:metabolism*; D007375:Interleukin-1 / Q000378:metabolism*; D009154:Mutation
chemical_list: D058847:Inflammasomes; D007375:Interleukin-1
keywords: Anakinra; Auto-inflammation; Maladie de Still; NLRP3; Pyrin; Pyrine; Still's disease