title: Relationship between cardio-ankle vascular index and homocysteine in hypertension subjects with hyperhomocysteinemia.
abstract: BACKGROUND
  Arteriosclerosis evaluated by arterial stiffness is the basic pathophysiological change during the development of hypertension. Cardio-ankle vascular index (CAVI) is an index of arterial stiffness. Hyperhomocysteinemia (HHcy) is an independent risk factor for vascular diseases. However, there was little research about the relationship between CAVI and homocysteine (Hcy) in hypertension subjects with HHcy.
  
  
  METHODS
  A total of 330 subjects (M/F 133/197) from Vascular Medicine of Peking University Shougang Hospital were divided into four groups: control group (group 1, normotensive with normal Hcy, n = 149), hypertension group (group 2, n = 113), HHcy group (group 3, n = 30), and hypertension with HHcy group (group 4, n = 38). CAVI was measured by VS-1000 apparatus.
  
  
  RESULTS
  Our results showed that CAVI was significantly higher in group 4 than in group 1 and group 2 (8.41 ± 1.08 vs. 7.79 ± 1.14; 8.41 ± 1.08 vs. 7.87 ± 1.02, both p < 0.05, respectively). Positive correlation between CAVI and Hcy was found in the entire study group (r = 0.109, p = 0.049) and hypertension subjects (group 2 + group 4; r = 0.202, p = 0.014). Multivariate analysis showed that Hcy was an independent associating factor of CAVI in all subjects (β = 0.251, p = 0.034).
  
  
  CONCLUSIONS
  The present study showed that CAVI was significantly higher in hypertension subjects with HHcy compared to hypertension group. There was significant correlation between CAVI and Hcy, indicating the relationship between arterial stiffness and biomarkers in vascular-related diseases.
authors.affiliation: a Department of Vascular Medicine , Peking University Shougang Hospital , Beijing , P. R. of China.
authors.forename: Jinbo
authors.initials: J
authors.lastname: Liu
authors.affiliation: a Department of Vascular Medicine , Peking University Shougang Hospital , Beijing , P. R. of China.
authors.forename: Huan
authors.initials: H
authors.lastname: Liu
authors.affiliation: a Department of Vascular Medicine , Peking University Shougang Hospital , Beijing , P. R. of China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Zhao
authors.affiliation: a Department of Vascular Medicine , Peking University Shougang Hospital , Beijing , P. R. of China.
authors.forename: Yingyan
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: a Department of Vascular Medicine , Peking University Shougang Hospital , Beijing , P. R. of China.
authors.forename: Lihong
authors.initials: L
authors.lastname: Li
authors.affiliation: a Department of Vascular Medicine , Peking University Shougang Hospital , Beijing , P. R. of China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Wang
mesh_terms: D000369:Aged, 80 and over; D000842:Ankle / Q000098:blood supply; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D001795:Blood Pressure Determination / Q000379:methods*; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000150:complications; D006973:Hypertension / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D063177:Pulse Wave Analysis / Q000379:methods*; D015203:Reproducibility of Results; D012307:Risk Factors; D013223:Statistics as Topic; D059289:Vascular Stiffness / Q000502:physiology*
chemical_list: D015415:Biomarkers; D006710:Homocysteine
keywords: Arterial function; cardio-ankle vascular index; hyperhomocysteinemia; hypertension; hypertension complications