title: Comparison of maternal serum lipoproteins in normal pregnancy and primiparous patients with eclampsia.
abstract: OBJECTIVE
  To evaluate changes in serum lipoproteins in primiparous women with eclampsia and compare it with pregnant women having normal blood pressure.
  
  
  METHODS
  This cross sectional study was conducted on 65 primiparous eclamptic patients and 21 normotensive pregnant women in the tertiary care hospitals of Peshawar. History of each woman was recorded on a questionnaire. Blood pressure was measured using standard methods. About 5 ml of venous blood was drawn for the analysis of lipoproteins. The data was analyzed using computer software package SPSS version 10. The P value <0.05 was considered statistically significant.
  
  
  RESULTS
  Mean age of hypertensive cases was 23.2 ± 0.52 years while that for controls was 23.9 ± 1.16 years. Significant differences were found in serum lipoproteins. Women having eclampsia had 28.8%, 29.5%, 31.1%, 32.9% and 65.3% higher, low density lipoprotein-cholesterol (LDLC), triglycerides (TG), total cholesterol (TC):high density lipoprotein-cholesterol (HDLC) ratio, LDLC: HDLC ratio and TG: HDLC ratio respectively as compared to the control group. The HDLC concentrations, HDLC: VLDLC ratio and apolipoprotein-A1 level were 26.9%, 56.6% and 27.9% respectively, lower in the patient group as compared to the controls.
  
  
  CONCLUSIONS
  This study suggests that evaluation of lipoprotein concentrations during antenatal period can be helpful in the early detection and prevention of developing eclampsia.
authors.affiliation: Dr. Rubina Nazli, MBBS, PhD. Assoc. Prof. of Biochemistry, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan.
authors.forename: Rubina
authors.initials: R
authors.lastname: Nazli
authors.affiliation: Dr. Tasleem Akhtar, M. Phil, PhD Chemistry. Senior Scientific Officer (Rtd), PMRC Research Centre, Khyber Medical College, Peshawar, Pakistan.
authors.forename: Tasleem
authors.initials: T
authors.lastname: Akhtar
authors.affiliation: Dr. Nabila Sher Mohammad MBBS, M.Phil. Assistant Professor of Biochemistry, Khyber Girls Medical College, Peshawar, Pakistan.
authors.forename: Nabila
authors.initials: N
authors.lastname: Sher
authors.affiliation: Jamila Haider, BS Microbiology, Dept. of Microbiology, Swat University, KPK, Pakistan.
authors.forename: Jamila
authors.initials: J
authors.lastname: Haider
authors.affiliation: Dr. Mohammad Akmal Khan, MBBS, MCPS, FCPS. Psychiatry Unit, Hayatabad Medical Complex, Peshawar, Pakistan.
authors.forename: M Akmal
authors.initials: MA
authors.lastname: Khan
authors.affiliation: Dr. Hina Aslam, MBBS, FCPS-1. Gynea Unit, Hayatabad Medical Complex, Peshawar, Pakistan.
authors.forename: Hina
authors.initials: H
authors.lastname: Aslam
keywords: Eclampsia; Hypertension; Lipoproteins; Primiparous women