title: Hepatitis C virus (HCV) reactivation during fingolimod treatment for relapsing and remitting multiple sclerosis.
abstract: We here report a case involving a 38-year-old female with relapsing and remitting multiple sclerosis who developed reactivation of hepatitis C virus (HCV) during administration of fingolimod for 16 months. She had been previously treated for chronic hepatitis C with pegylated interferon and ribavirin, and kept an undetectable HCV-RNA state for more than 4 years before fingolimod starting. Although the increased risk for viral reactivation, for example of herpes zoster virus and varicella-zoster virus, during fingolimod treatment is known, this is, to our knowledge, the first case report of HCV reappearance.
authors.affiliation: Departments of Neurology, International University of Health and Welfare Hospital, 537-3 Iguchi Nasushiobara City, Tochigi 329-2763, Japan. Electronic address: tagawa@iuhw.ac.jp.
authors.forename: Asako
authors.initials: A
authors.lastname: Tagawa
authors.affiliation: Departments of Neurology, International University of Health and Welfare Hospital, 537-3 Iguchi Nasushiobara City, Tochigi 329-2763, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Ogawa
authors.affiliation: Departments of Neurology, International University of Health and Welfare Hospital, 537-3 Iguchi Nasushiobara City, Tochigi 329-2763, Japan.
authors.forename: Syuichi
authors.initials: S
authors.lastname: Tetsuka
authors.affiliation: Departments of Neurology, International University of Health and Welfare Hospital, 537-3 Iguchi Nasushiobara City, Tochigi 329-2763, Japan.
authors.forename: Mieko
authors.initials: M
authors.lastname: Otsuka
authors.affiliation: Departments of Neurology, International University of Health and Welfare Hospital, 537-3 Iguchi Nasushiobara City, Tochigi 329-2763, Japan.
authors.forename: Ritsuo
authors.initials: R
authors.lastname: Hashimoto
authors.affiliation: Departments of Neurology, International University of Health and Welfare Hospital, 537-3 Iguchi Nasushiobara City, Tochigi 329-2763, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kato
authors.affiliation: Departments of Gastroenterology, International University of Health and Welfare Hospital, 537-3, Iguchi Nasushiobara City, Tochigi 329-2763, Japan.
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Ando
authors.affiliation: Departments of Gastroenterology, International University of Health and Welfare Hospital, 537-3, Iguchi Nasushiobara City, Tochigi 329-2763, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Tanabe
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging; D066193:Cervical Cord / Q000000981:diagnostic imaging; D005260:Female; D000068876:Fingolimod Hydrochloride / Q000009:adverse effects* / Q000627:therapeutic use; D016174:Hepacivirus; D006526:Hepatitis C / Q000150:complications* / Q000000981:diagnostic imaging; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy*; D012008:Recurrence
chemical_list: D007166:Immunosuppressive Agents; D000068876:Fingolimod Hydrochloride
keywords: Fingolimod; Hepatitis C virus; Multiple sclerosis; Reactivation