title: Anti Mullerian Hormone: Ovarian response indicator in young patients receiving Long GnRH Agonist Protocol for Ovarian Stimulation.
abstract: OBJECTIVE
  Anti Mullerian hormone (AMH) is gaining place as ovarian marker, chiefly in infertility assistance. We explored its correlation with oocytes retrieval after long GnRH agonist protocol for stimulation, in younger and older infertile population.
  
  
  METHODS
  This retrospective analysis compiled data of 166 females, receiving ICSI treatment from June 2014 to March 2015. Serum FSH, LH, Estadiol, AMH and antral follicle count were assessed. Outcomes were measured as good (5 to 19 oocytes) and bad responders.
  
  
  RESULTS
  Higher discriminatory power of AMH (AUROC; 0.771; p < 0.05) was seen in comparison to FSH (0.692; p < 0.05) and AFC (0.690; p < 0.01). AMH reported strongest association with oocyte retrieved (odds ratio of 15.06). Subgroup analysis reported 68.6 % risk of bad response with AMH levels of less than 1.37ng/ml. This association was observed more significant in young infertile patients <35 year of age (r=0.245; p=0.012) versus older population >35 year (r=0.169; p>0.05).
  
  
  CONCLUSIONS
  Our study reaffirms that serum AMH correlates well with oocytes retrieved, particularly in females younger than 35 years. We suggest incorporation of AMH in baseline assessment of infertile females, who are falsely advised to postpone interventions based on their age and normal FSH levels.
authors.affiliation: Zehra Jamil, Department of Biological & Biomedical Sciences, Aga Khan University, Karachi, Pakistan.
authors.forename: Zehra
authors.initials: Z
authors.lastname: Jamil
authors.affiliation: Syeda Sadia Fatima, Department of Biological & Biomedical Sciences, Aga Khan University, Karachi, Pakistan.
authors.forename: Syeda Sadia
authors.initials: SS
authors.lastname: Fatima
authors.affiliation: Rehana Rehman, Department of Biological & Biomedical Sciences, Aga Khan University, Karachi, Pakistan.
authors.forename: Rehana
authors.initials: R
authors.lastname: Rehman
authors.affiliation: Faiza Alam, Department of Biological & Biomedical Sciences, Aga Khan University, Karachi, Pakistan.
authors.forename: Faiza
authors.initials: F
authors.lastname: Alam
authors.affiliation: Sara Arif, Intern, Civil Hospital, Karachi, Pakistan.
authors.forename: Sara
authors.initials: S
authors.lastname: Arif
keywords: Anti Mullerian Hormone; Assisted Reproductive Technology; Ovarian reserve; Ovarian stimulation