title: Fecal Microbiota Transplant in Patients With Recurrent Clostridium Difficile Infection.
abstract: The clinical effectiveness of fecal microbiota transplant (FMT) for the treatment of recurrent Clostridium difficile infections (rCDI) has been demonstrated in randomized controlled trials. To assess the current status of FMT in Germany with respect to active centers, local standards, clinical effectiveness and safety, the MicroTrans Registry (NCT02681068) was established.
  
  
  
  In a long-term retrospective multicenter observational study by the German Clinical Microbiome Study Group (GCMSG), primary and secondary cure on day 30 and 90, as well as occurrence of treatment-related adverse events were assessed. In addition to patient demographic data, we provide an overview of the FMT procedures and techniques used at different centers.
  
  
  
  Overall, 133 eligible patients from 33 centers were included, of which 64.7% were female (n = 86). The mean age was 75 years (interquartile range: 59.5-81.5). Administration via the duodenal route (n = 59; 44.4%) was the most frequently applied option, followed by colonic (n = 55; 41.1%), capsule (n = 13; 9.8%), and gastric administration (n = 4; 3.0%). Primary cure on day 30 and 90 was achieved in 84.2% (n = 101/120) and 78.3% (n = 72/92) of patients, respectively. Including re-treatment, secondary response was achieved in 87.5% (d 30; n = 105/120) and 85.9% (d 90; n = 79/92), respectively. Treatment- elated adverse events were documented in 16 patients (12.0%).
  
  
  
  FMT is a safe and effective treatment option for rCDI. However, FMT is currently available only in few centers in Germany, and treatment options vary from one center to another.
authors.affiliation: Center for Infectious Diseases and Infection Control, Jena University Hospital|Jena, Department of Internal Medicine IV (Gastroenterology, Hepatology and Infectious Diseases), Jena University Hospital, Jena
authors.forename: Stefan
authors.initials: S
authors.lastname: Hagel
authors.forename: Anne
authors.initials: A
authors.lastname: Fischer
authors.forename: Philipp
authors.initials: P
authors.lastname: Ehlermann
authors.forename: Thorsten
authors.initials: T
authors.lastname: Frank
authors.forename: Kester
authors.initials: K
authors.lastname: Tueffers
authors.forename: Andreas
authors.initials: A
authors.lastname: Sturm
authors.forename: Alexander
authors.initials: A
authors.lastname: Link
authors.forename: Muenevver
authors.initials: M
authors.lastname: Demir
authors.forename: Arno
authors.initials: A
authors.lastname: Siebenhaar
authors.forename: Martin
authors.initials: M
authors.lastname: Storr
authors.forename: Thomas
authors.initials: T
authors.lastname: Glueck
authors.forename: Erhard
authors.initials: E
authors.lastname: Siegel
authors.forename: Philip
authors.initials: P
authors.lastname: Solbach
authors.forename: Felix
authors.initials: F
authors.lastname: Goeser
authors.forename: Christian B.
authors.initials: CB
authors.lastname: Koelbel
authors.forename: Ansgar
authors.initials: A
authors.lastname: Lohse
authors.forename: Christoph
authors.initials: C
authors.lastname: Luebbert
authors.forename: Ulrich
authors.initials: U
authors.lastname: Kandzi
authors.forename: Matthias
authors.initials: M
authors.lastname: Maier
authors.forename: Stefanie
authors.initials: S
authors.lastname: Schuerle
authors.forename: Markus M.
authors.initials: MM
authors.lastname: Lerch
authors.forename: Daniela
authors.initials: D
authors.lastname: Tacke
authors.forename: Oliver A.
authors.initials: OA
authors.lastname: Cornely
authors.affiliation: Jena, Department of Internal Medicine IV (Gastroenterology, Hepatology and Infectious Diseases), Jena University Hospital, Jena
authors.forename: Andreas
authors.initials: A
authors.lastname: Stallmach
authors.affiliation: Department I of Internal Medicine and Center for Integrated Oncology CIO Köln/Bonn, University Hospital of Cologne; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne
authors.forename: Maria
authors.initials: M
authors.lastname: Vehreschild
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003015:Clostridium Infections / Q000382:microbiology / Q000401:mortality* / Q000628:therapy*; D000069467:Fecal Microbiota Transplantation / Q000379:methods / Q000401:mortality* / Q000706:statistics & numerical data*; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012008:Recurrence; D012042:Registries; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome