title: Is body mass index relevant to prognosis of papillary thyroid carcinoma? A clinicopathological cohort study.
abstract: OBJECTIVE
  Obesity appears to be related to papillary thyroid carcinoma (PTC) in the observational studies, although its relationship concerning the PTC prognosis has not been established. We investigated the association between body mass index (BMI) and the prognosis of PTC.
  
  
  METHODS
  The WHO BMI classification was used to stratify the degree of obesity. The final outcome was disease status, including recurrence and persistence, of 783 PTC patients. We reviewed patients' BMI, disease status, and other prognostic factors retrospectively.
  
  
  RESULTS
  The mean BMI was 24.2 kg/m2. When stratified according to the WHO BMI classification, 21 were Underweight, 482 were Normal, 232 were Overweight, and 48 were Obese. We divided patients into two groups: <25.0 kg/m2(n = 503) vs. ≥25.0 kg/m2(n = 280). The BMI ≥25.0 group was older and more likely to be male in a multivariate analysis (p < 0.001). For those with BMI <25.0 and ≥25.0, recurrence occurred in 3.0 and 2.1 % (p = 0.486), persistence in 7.2 and 5.1 % (p = 0.265), and either recurrence or persistence in 9.9 and 7.1 %, respectively (p = 0.189). A multivariate analysis revealed that older age and male gender in Overweight vs. Normal, older age in Obese vs. Normal, and advanced T stage in Normal vs. Underweight were statistically significant prognostic factors.
  
  
  CONCLUSIONS
  There was no significant difference in the prognosis according to BMI in PTC patients. However, old age, male gender, and advanced T-stage patients were found more frequently in the higher BMI group than in the lower BMI group.
authors.affiliation: Thyroid and Endocrine Surgery Section, Department of Surgery, Gachon University Gil Medical Center, Gachon University School of Medicine, Gachon University, 1198 Guwol-dong, Namdong-gu, Incheon, 405-760, Republic of Korea.
authors.forename: Yoo Seung
authors.initials: YS
authors.lastname: Chung
authors.affiliation: Thyroid and Endocrine Surgery Section, Department of Surgery, Gachon University Gil Medical Center, Gachon University School of Medicine, Gachon University, 1198 Guwol-dong, Namdong-gu, Incheon, 405-760, Republic of Korea.
authors.forename: Joon-Hyop
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Thyroid and Endocrine Surgery Section, Department of Surgery, Gachon University Gil Medical Center, Gachon University School of Medicine, Gachon University, 1198 Guwol-dong, Namdong-gu, Incheon, 405-760, Republic of Korea. peacemk@gilhospital.com.
authors.forename: Young Don
authors.initials: YD
authors.lastname: Lee
mesh_terms: D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D002277:Carcinoma / Q000473:pathology; D002291:Carcinoma, Papillary; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D009765:Obesity; D011379:Prognosis; D012737:Sex Factors; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000473:pathology
keywords: BMI; Obesity; Papillary thyroid carcinoma; Prognosis