title: Noncoding RNA Interplay with the Genome.
abstract: The majority of our genome is transcribed to produce RNA molecules that are mostly noncoding. Among them, long noncoding RNAs (lncRNAs) are the most numerous and functionally versatile class.LncRNAs have emerged as key regulators of gene expression at multiple levels.This section describes bioinformatics aspects important for lncRNA discovery and molecular approaches to perform structure-function characterization of this exciting class of regulatory molecules.
authors.affiliation: Dulbecco Telethon Institute and Division of Regenerative Medicine, San Raffaele Scientific Institute, Milano, Italy. gabellini.davide@hsr.it.
authors.forename: Davide
authors.initials: D
authors.lastname: Gabellini
mesh_terms: D005786:Gene Expression Regulation / Q000235:genetics*; D016678:Genome; D008967:Molecular Biology / Q000379:methods*; D062085:RNA, Long Noncoding / Q000235:genetics*; D013329:Structure-Activity Relationship
chemical_list: D062085:RNA, Long Noncoding
keywords: Bioinformatics; ChIRP; Chart; LncRNA; RAP; RIP; RNA pull-down; RNA-seq