title: Capillary and Venous Lactate Agreement: a pilot prospective observational study.
abstract: BACKGROUND
  Blood lactate is a marker of patient illness severity. Capillary lactate (CAP-LACT) measurement can potentially improve patient screening; however, it has poor evidence of clinical utility.
  
  
  OBJECTIVE
  We aimed to investigate agreement between CAP-LACT and peripheral venous lactate (PV-LACT).
  
  
  METHODS
  We performed a prospective observational pilot study of 99 patients requiring lactate measurement. Paired CAP-LACT and PV-LACT was recorded. Agreement was determined by Bland-Altman analysis.
  
  
  RESULTS
  Bias was 0.2 mmol/L, with 95% limits of agreement from -1.9 to 2.3.
  
  
  CONCLUSIONS
  CAP-LACT has poor agreement with PV-LACT. Further research is needed to improve its potential clinical utility.
authors.affiliation: Emergency Medicine Research Group Edinburgh, Department of Emergency Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK.
authors.forename: Deepankar
authors.identifier: http://orcid.org/0000-0001-9971-9434
authors.initials: D
authors.lastname: Datta
authors.affiliation: Emergency Medicine Research Group Edinburgh, Department of Emergency Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK.
authors.forename: Julia
authors.initials: J
authors.lastname: Grahamslaw
authors.affiliation: Emergency Medicine Research Group Edinburgh, Department of Emergency Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK.
authors.forename: Alasdair James
authors.initials: AJ
authors.lastname: Gray
authors.affiliation: Wellcome Trust Clinical Research Facility, Western General Hospital, Edinburgh, UK.
authors.forename: Catriona
authors.initials: C
authors.lastname: Graham
mesh_terms: D000293:Adolescent; D000328:Adult; D001784:Blood Gas Analysis / Q000379:methods; D002196:Capillaries / Q000737:chemistry*; D005260:Female; D006801:Humans; D019344:Lactic Acid / Q000032:analysis* / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D006113:United Kingdom; D014680:Veins / Q000737:chemistry*
chemical_list: D019344:Lactic Acid
keywords: assessment; clinical care; equipment evaluation