title: [Role of correction of the syndrome of intestinal failure and abdominal hypertension in the prevention of infection of pancreatic necrosis].
abstract: The number of patients with acute pancreatitis and pancreatic necrosis has been steadily increasing. Mortality in infected pancreatic necrosis remains high.
  
  
  OBJECTIVE
  To develop measures to prevent infection of pancreatic necrosis by timely correction of intra-abdominal hypertension and the syndrome of intestinal failure.
  
  
  METHODS
  Developed a package of measures, consisting of early intestinal lavage and enterosorption, intravenous highdoses of octreotide, epidural blockade, adequate detox and the start of effective antimicrobial therapy. Comparative evaluation of clinical, laboratory and instrumental data in the primary (n=50) and control (n=50) groups.
  
  
  RESULTS
  In the main group pancreatogenic sepsis occurred in 10%, control 18%. Mortality, respectively, was 8 and 16%.
authors.affiliation: MSMSU them. A.I. Evdokimov Department of surgical diseases and clinical angiology, Moscow, Russia.
authors.forename: M D
authors.initials: MD
authors.lastname: Dibirov
authors.affiliation: MSMSU them. A.I. Evdokimov Department of surgical diseases and clinical angiology, Moscow, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Isaev
authors.affiliation: MSMSU them. A.I. Evdokimov Department of surgical diseases and clinical angiology, Moscow, Russia.
authors.forename: A B
authors.initials: AB
authors.lastname: Jadjiev
authors.affiliation: MSMSU them. A.I. Evdokimov Department of surgical diseases and clinical angiology, Moscow, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Ashimova
authors.affiliation: MSMSU them. A.I. Evdokimov Department of surgical diseases and clinical angiology, Moscow, Russia.
authors.forename: T
authors.initials: T
authors.lastname: Ataev
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy / Q000379:methods; D019446:Endotoxemia / Q000175:diagnosis / Q000628:therapy; D005260:Female; D005440:Fluid Therapy / Q000379:methods; D005769:Gastrointestinal Motility; D006440:Hemofiltration / Q000379:methods; D006801:Humans; D007415:Intestinal Obstruction / Q000175:diagnosis / Q000628:therapy; D059325:Intra-Abdominal Hypertension / Q000175:diagnosis / Q000628:therapy; D008297:Male; D008875:Middle Aged; D019283:Pancreatitis, Acute Necrotizing / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D016060:Sorption Detoxification / Q000379:methods; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents