title: A prediction model of survival for patients with bone metastasis from uterine corpus cancer.
abstract: OBJECTIVE
  The aim of the study was to establish a predictive model of survival period after bone metastasis from endometrial cancer.
  
  
  METHODS
  A total of 28 patients with bone metastasis from uterine corpus cancer were included in the study. Data at the time of bone metastasis diagnosis, which included presence of extraskeletal metastasis, performance status, history of any previous radiation/chemotherapy and the number of bone metastases, were collected. Survival data were analyzed using Kaplan-Meier methods and Cox proportional hazard models.
  
  
  RESULTS
  The most common site of bone metastasis was the pelvis (50.0%), followed by lumbar spine (32.1%), thoracic spine (25.0%) and rib bone (17.9%). The median survival period after bone metastasis was 25 weeks. The overall rate of survival after bone metastasis of the entire cohort was 75.0% at 13 weeks, 46.4% at 26 weeks and 42.9% at 52 weeks. Performance status of 3-4 was confirmed as an independent prognostic factor (Hazard ratio, 3.5; 95% confidence interval, 1.41-8.70) and multiple bone metastases tended to be associated with poor prognosis (Hazard ratio, 2.4; 95% confidence interval, 0.95-5.97). A prognostic score was calculated by adding up the number of these two factors. The 26-week survival rates after bone metastasis were 88.9% for those with a score of 0, 45.5% for those with a score of 1 and 0% for those with a score of 2 (P = 0.0006).
  
  
  CONCLUSIONS
  This scoring system can be used to determine the optimal treatment for patients with bone metastasis from endometrial cancer.
authors.affiliation: Division of Gynecologic Oncology, National Hospital Organization, Hokkaido Cancer Center, Shiroishi-ku, Sapporo.
authors.forename: Sho
authors.initials: S
authors.lastname: Takeshita
authors.affiliation: Division of Gynecologic Oncology, National Hospital Organization, Hokkaido Cancer Center, Shiroishi-ku, Sapporo.
authors.forename: Yukiharu
authors.initials: Y
authors.lastname: Todo
authors.affiliation: Division of Gynecologic Oncology, National Hospital Organization, Hokkaido Cancer Center, Shiroishi-ku, Sapporo.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Matsumiya
authors.affiliation: Division of Gynecologic Oncology, National Hospital Organization, Hokkaido Cancer Center, Shiroishi-ku, Sapporo.
authors.forename: Kazuhira
authors.initials: K
authors.lastname: Okamoto
authors.affiliation: Division of Pathology, National Hospital Organization, Hokkaido Cancer Center, Shiroishi-ku, Sapporo, Japan.
authors.forename: Katsushige
authors.initials: K
authors.lastname: Yamashiro
authors.affiliation: Division of Gynecologic Oncology, National Hospital Organization, Hokkaido Cancer Center, Shiroishi-ku, Sapporo.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Kato
keywords: bone metastasis; endometrial cancer; performance status; prognosis