title: Meta-analysis of CYP2E1 polymorphisms in liver carcinogenesis.
abstract: BACKGROUND
  The CYP2E1 protein is a monooxygenase with certain polymorphisms linked to liver cancer. However, results from individual studies remain controversial.
  
  
  OBJECTIVE
  To evaluate CYP2E1 polymorphisms in liver carcinogenesis through meta-analysis.
  
  
  METHODS
  All studies about CYP2E1 polymorphisms and liver cancer were retrieved from seven major databases. Original data from each study were pooled and re-analyzed.
  
  
  RESULTS
  Total of 16 articles with 4862 cases were selected, including 1820 cases of liver cancer and 3042 cases of controls. The c1 allelic frequency in the cases and controls was 83.3% and 85.3%, respectively. Five genetic variations were compared: dominant c1c2/c2c2 vs. c1/c1 (OR=0.987 (0.853, 1.141)), homozygous c2c2 vs. c1c1 (OR=0.767 (0.526, 1.119)), heterozygous c1c2 vs. c1c1 (OR=1.005 (0.854, 1.182)), recessive c2c2 vs. c1c2/c2c2 (OR=0.771 (0.530, 1.122)), and different alleles c2 vs. c1 (OR=0.947 (0.828, 1.082)). Pooled data were further analyzed based on ethnicity, control sources, and HWE (Hardy-Weinberg equilibrium). These results from stratified groups were similar to that of nonstratified groups.
  
  
  CONCLUSIONS
  Our meta-analysis results suggest that there is no evidence for a major role of CYP2E1 polymorphism in liver carcinogenesis, but do not rule out the possibility in certain cases.
authors.affiliation: Department of Hepatobiliary-Pancreatic Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
authors.forename: Peiyao
authors.initials: P
authors.lastname: Fu
authors.affiliation: Department of Cardiothoracic Surgery, Changhai Hospital of the Second Military Medical University, Shanghai, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.affiliation: Department of Epidemiology, School of Public Health of Jilin University, Changchun, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.affiliation: Department of Hepatobiliary-Pancreatic Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
authors.forename: Biao
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Hepatobiliary-Pancreatic Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
authors.forename: Lianyue
authors.initials: L
authors.lastname: Guan
authors.affiliation: Department of Hepatobiliary-Pancreatic Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
authors.forename: Jiyao
authors.initials: J
authors.lastname: Sheng
authors.affiliation: Department of Hepatobiliary-Pancreatic Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
authors.forename: Yanshuo
authors.initials: Y
authors.lastname: Ye
authors.affiliation: Department of Hepatobiliary-Pancreatic Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
authors.forename: Zhanpeng
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Tumor Therapy, Tumor Hospital of Jilin Province, Changchun, China.
authors.forename: Peidong
authors.initials: P
authors.lastname: Li
authors.affiliation: Department of Cardiothoracic Surgery, Changhai Hospital of the Second Military Medical University, Shanghai, China.
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Cardiothoracic Surgery, Changhai Hospital of the Second Military Medical University, Shanghai, China.
authors.forename: Liangjian
authors.initials: L
authors.lastname: Zou
authors.affiliation: Department of Hepatobiliary-Pancreatic Surgery, China-Japan Union Hospital of Jilin University, Changchun, China. Electronic address: weili888@hotmail.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
mesh_terms: D000483:Alleles; D063646:Carcinogenesis / Q000235:genetics*; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D019392:Cytochrome P-450 CYP2E1
keywords: CYP2E1; Database; Liver cancer; Polymorphism