title: TNF-α and LT-α polymorphisms and the risk of leukemia: a meta-analysis.
abstract: OBJECTIVE
  The aim of this study is to investigate whether TNF-α or LT-α polymorphisms are associated with the risk of leukemia.
  
  
  METHODS
  A meta-analysis was performed to examine the association between the TNF-α -308 G&gt;A and LT-α +252 A&gt;G polymorphisms and the incidence of leukemia. We also performed subgroup analyses based on the classification of leukemias. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the association.
  
  
  RESULTS
  A total of 19 publications comprising 1,509 cases and 4,075 controls were selected in the study. An association between the risk of leukemia and the LT-α +252 AA genotype was found (GG + AG vs. AA, OR = 0.485, 95% CI 0.368-0.639, p = 0.000). After multivariable analysis TNF-α polymorphism showed no consistent association with leukemia.
  
  
  CONCLUSIONS
  This meta-analysis suggests that the LT-α +252 AA polymorphism is associated with the risk of leukemia.
authors.affiliation: Beijing Chao-Yang Hospital, Capital Medical University, Beijing - China.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Gong
authors.affiliation: Beijing Chao-Yang Hospital, Capital Medical University, Beijing - China.
authors.forename: Fei-Fei
authors.initials: FF
authors.lastname: Han
authors.affiliation: Beijing Chao-Yang Hospital, Capital Medical University, Beijing - China.
authors.forename: Ya-Li
authors.initials: YL
authors.lastname: Lv
authors.affiliation: Beijing Chao-Yang Hospital, Capital Medical University, Beijing - China.
authors.forename: He
authors.initials: H
authors.lastname: Liu
authors.affiliation: Beijing Chao-Yang Hospital, Capital Medical University, Beijing - China.
authors.forename: Zi-Rui
authors.initials: ZR
authors.lastname: Wan
authors.affiliation: Beijing Chao-Yang Hospital, Capital Medical University, Beijing - China.
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Beijing Chao-Yang Hospital, Capital Medical University, Beijing - China.
authors.forename: Ming-Biao
authors.initials: MB
authors.lastname: Shi
authors.affiliation: Beijing Chao-Yang Hospital, Capital Medical University, Beijing - China.
authors.forename: Li-Xia
authors.initials: LX
authors.lastname: Pei
authors.affiliation: Beijing Chao-Yang Hospital, Capital Medical University, Beijing - China.
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Liu
mesh_terms: D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D008233:Lymphotoxin-alpha / Q000235:genetics*; D011110:Polymorphism, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha