title: Molecular tools for acute spatiotemporal manipulation of signal transduction.
abstract: The biochemical activities involved in signal transduction in cells are under tight spatiotemporal regulation. To study the effects of the spatial patterning and temporal dynamics of biochemical activities on downstream signaling, researchers require methods to manipulate signaling pathways acutely and rapidly. In this review, we summarize recent developments in the design of three broad classes of molecular tools for perturbing signal transduction, classified by their type of input signal: chemically induced, optically induced, and magnetically induced.
authors.affiliation: Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Ross
authors.affiliation: Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.
authors.forename: Sohum
authors.initials: S
authors.lastname: Mehta
authors.affiliation: Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA; Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD, USA. Electronic address: jzhang32@ucsd.edu.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
mesh_terms: D008280:Magnetics; D055095:Optics and Photonics; D015398:Signal Transduction