title: The future therapy of endometrial cancer: microRNA's functionality, capability, and putative clinical application.
abstract: Endometrial cancer (EC) therapy is characterized by the heterogeneity of EC subtypes resulting in unclear clinical behavior as well as in unsatisfactory treatment options. The available biomarkers, such as cellular tumor antigen p53 (TP53), phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase (PTEN), and phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) genes alone might not be sufficient, and thus, new predictive and prognostic biomarkers are urgently required. The biomolecule class of microRNA represents a group of endogenously expressed regulatory factors primarily involved in control of pivotal cancer-related mechanisms including cell cycle, proliferation, apoptosis, and metastasis. Here, we review the current state of science regarding microRNA functionality in EC progression.
authors.affiliation: Cancer Laboratory, Department of Urology, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany. matthias.stope@uni-greifswald.de.
authors.forename: Matthias B
authors.initials: MB
authors.lastname: Stope
authors.affiliation: Department of Gynaecology and Obstetrics, University Medicine Greifswald, Greifswald, Germany.
authors.forename: Dominique
authors.initials: D
authors.lastname: Koensgen
authors.affiliation: Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany.
authors.forename: Jörg
authors.initials: J
authors.lastname: Weimer
authors.affiliation: Department of Gynaecology and Obstetrics, University Medicine Greifswald, Greifswald, Germany.
authors.forename: Madeleine
authors.initials: M
authors.lastname: Paditz
authors.affiliation: Cancer Laboratory, Department of Urology, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Burchardt
authors.affiliation: Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Bauerschlag
authors.affiliation: Department of Gynaecology and Obstetrics, University Medicine Greifswald, Greifswald, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Mustea
mesh_terms: D016889:Endometrial Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D011379:Prognosis
chemical_list: D035683:MicroRNAs
keywords: Biomarker; Diagnosis; Endometrial cancer; MicroRNA; Prognosis