title: Calcification of the aortic valve and mitral apparatus: location, quantification and implications for device selection.
abstract: The treatment of both aortic and now mitral valvular disease has been transformed through transcatheter valvular interventions. TAVR has rapidly become the treatment of choice for symptomatic severe aortic stenosis in both high, and now intermediate-risk patients. Building upon this success the last two years have seen the clinical introduction of transcatheter mitral valve replacement (TMVR), with a number of devices being utilised in first-in-man and feasibility studies. These experiences have helped determine the anatomical requirements and specifications that enable successful device deployment and avoidance of complications. A unique strength of cardiac CT is the ability to identify and characterise calcification of the aortic and mitral apparatus, en-abling a deeper understanding of the relationship of calcification and procedural complications.
authors.affiliation: Centre for Heart Valve Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Jonathon
authors.initials: J
authors.lastname: Leipsic
authors.forename: Philipp
authors.initials: P
authors.lastname: Blanke
mesh_terms: D001021:Aortic Valve / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D001024:Aortic Valve Stenosis / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery; D002114:Calcinosis / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery; D006328:Cardiac Catheterization / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D008943:Mitral Valve / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery; D018579:Patient Selection; D011237:Predictive Value of Tests; D011474:Prosthesis Design; D015641:Radiography, Interventional / Q000009:adverse effects / Q000379:methods*; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D065467:Transcatheter Aortic Valve Replacement / Q000295:instrumentation / Q000379:methods; D016896:Treatment Outcome