title: Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy.
abstract: The paper presents current evidence on the properties of human umbilical cord-derived mesenchymal stem cells, including origin, proliferative potential, plasticity, stability of karyotype and phenotype, transcriptome, secretome, and immunomodulatory activity. A review of preclinical studies and clinical trials using this cell type is performed. Prospects for the use of mesenchymal stem cells, derived from the umbilical cord, in cell transplantation are associated with the need for specialized biobanking and transplant standardization criteria.
authors.affiliation: Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of the Russian Federation, No. 4, Oparin Street, Moscow 117997, Russia.
authors.forename: Irina
authors.identifier: 0000-0002-4344-8943
authors.initials: I
authors.lastname: Arutyunyan
authors.affiliation: Pirogov Russian National Research Medical University, Ministry of Healthcare of the Russian Federation, No. 1, Ostrovitianov Street, Moscow 117997, Russia.
authors.forename: Andrey
authors.identifier: 0000-0002-2392-4439
authors.initials: A
authors.lastname: Elchaninov
authors.affiliation: Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of the Russian Federation, No. 4, Oparin Street, Moscow 117997, Russia.
authors.forename: Andrey
authors.identifier: 0000-0003-2133-2293
authors.initials: A
authors.lastname: Makarov
authors.affiliation: Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of the Russian Federation, No. 4, Oparin Street, Moscow 117997, Russia; Pirogov Russian National Research Medical University, Ministry of Healthcare of the Russian Federation, No. 1, Ostrovitianov Street, Moscow 117997, Russia.
authors.forename: Timur
authors.identifier: 0000-0002-6498-5764
authors.initials: T
authors.lastname: Fatkhudinov