title: Iridoid glycosides from Callicarpa nudiflora Hook.
abstract: Four new iridoid glycoside derivatives (1-4), along with ten known iridoid glycosides (5-14), were isolated from Callicarpa nudiflora Hook et Arn. The structure of the new iridoid glycosides was elucidated as 5″-methoxy-ampicoside (1), 6″-O-trans-caffeoylcatalpol (2), 6″-O-trans-feruloylcatalpol (3) and 3″-methoxy-agnucastoside C (4) on the basis of spectroscopic analysis. Compounds 1-11 were reported from this plant for the first time. The cytotoxic activity of the isolated compounds against human cervical carcinoma Hela cells and ovarian carcinoma HeyA8 cells was evaluated using the microculture tetrazolium assay. Compounds 4, 5, 8, 12 and 13 showed cytotoxic activity against the Hela cell line with IC50values of 25.3, 48.1, 17.3, 38.3 and 28.2 μM, respectively. While only compound 8 showed cytotoxicity against the HeyA8 cell line, with an IC50of 35.5 μM.
authors.affiliation: a Key Laboratory of South Subtropical Plant Diversity , Fairy Lake Botanical Garden, Shenzhen & Chinese Academy of Sciences , Shenzhen , China.
authors.forename: Shi-Xiu
authors.initials: SX
authors.lastname: Feng
authors.affiliation: b Pharmacy Department of the 187th Hospital of People's Liberation Army , Haikou , China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yi
authors.affiliation: a Key Laboratory of South Subtropical Plant Diversity , Fairy Lake Botanical Garden, Shenzhen & Chinese Academy of Sciences , Shenzhen , China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.affiliation: a Key Laboratory of South Subtropical Plant Diversity , Fairy Lake Botanical Garden, Shenzhen & Chinese Academy of Sciences , Shenzhen , China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.affiliation: b Pharmacy Department of the 187th Hospital of People's Liberation Army , Haikou , China.
authors.forename: Hai
authors.initials: H
authors.lastname: Lin
authors.affiliation: b Pharmacy Department of the 187th Hospital of People's Liberation Army , Haikou , China.
authors.forename: Wen-Tong
authors.initials: WT
authors.lastname: Xu
mesh_terms: D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology; D032408:Callicarpa / Q000737:chemistry*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D006801:Humans; D057889:Iridoid Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D013057:Spectrum Analysis
chemical_list: D000970:Antineoplastic Agents; D057889:Iridoid Glycosides
keywords: Callicarpa nudiflora; cytotoxic activity; iridoid glycosides