title: Rosacea: Molecular Mechanisms and Management of a Chronic Cutaneous Inflammatory Condition.
abstract: Rosacea is a chronic cutaneous inflammatory disease that affects the facial skin. Clinically, rosacea can be categorized into papulopustular, erythematotelangiectatic, ocular, and phymatous rosacea. However, the phenotypic presentations of rosacea are more heterogeneous. Although the pathophysiology of rosacea remains to be elucidated, immunologic alterations and neurovascular dysregulation are thought to have important roles in initiating and strengthening the clinical manifestations of rosacea. In this article, we present the possible molecular mechanisms of rosacea based on recent laboratory and clinical studies. We describe the genetic predisposition for rosacea along with its associated diseases, triggering factors, and suggested management options in detail based on the underlying molecular biology. Understanding the molecular pathomechanisms of rosacea will likely aid toward better comprehending its complex pathogenesis.
authors.affiliation: Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 07345, Korea. w1206@naver.com.
authors.forename: Yu Ri
authors.initials: YR
authors.lastname: Woo
authors.affiliation: Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 07345, Korea. redtor@hanmail.net.
authors.forename: Ji Hong
authors.initials: JH
authors.lastname: Lim
authors.affiliation: Department of Life Science, Sookmyung Women's University, Seoul 04310, Korea. cdhkor@sookmyung.ac.kr.
authors.forename: Dae Ho
authors.initials: DH
authors.lastname: Cho
authors.affiliation: Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 07345, Korea. hjpark@catholic.ac.kr.
authors.forename: Hyun Jeong
authors.initials: HJ
authors.lastname: Park
mesh_terms: D000071797:Butyrophilins / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics; D059805:HLA-DR alpha-Chains / Q000235:genetics; D006801:Humans; D007107:Immune System / Q000378:metabolism; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics; D012393:Rosacea / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D012867:Skin / Q000469:parasitology / Q000528:radiation effects; D014466:Ultraviolet Rays
chemical_list: C408263:BTNL2 protein, human; D000071797:Butyrophilins; D059805:HLA-DR alpha-Chains; C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein; D005982:Glutathione Transferase
keywords: genetic; immune defect; inflammation; neurovascular dysregulation; rosacea; triggering factor