title: [Current Status of Translational Research on Constipation].
abstract: Constipation is one of the most common gastrointestinal disorders with a prevalence up to 16.5% in the general population. It is frequently multifactorial and the pathophysiologic mechanism of constipation is not fully understood. Many preclinical studies of constipation have used animal models. Translational research using these animal models is essential to the investigation of neurogenic and myogenic mechanisms of colon, and to the estimation of the clinical efficacy of new drugs. In this review, we discuss some of the current translational research projects on constipation using animal models.
authors.affiliation: Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
authors.forename: Hyun Jik
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
authors.forename: Kyung Sik
authors.initials: KS
authors.lastname: Park
mesh_terms: D000818:Animals; D020117:Cisapride / Q000627:therapeutic use; D003106:Colon / Q000502:physiology; D003248:Constipation / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D004195:Disease Models, Animal; D006801:Humans; D056885:Interstitial Cells of Cajal / Q000378:metabolism; D011985:Receptors, Serotonin / Q000737:chemistry / Q000378:metabolism; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use; D057170:Translational Research, Biomedical
chemical_list: D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; C078730:serotonin 5 receptor; D020117:Cisapride
keywords: Colon; Constipation; Gastrointestinal motility; Translational medical research