title: Class II Phosphoinositide 3-Kinases as Novel Drug Targets.
abstract: The phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases central to regulating a wide range of important intracellular processes. Despite the vast knowledge around class I PI3Ks, the class II PI3Ks have been neglected, seemingly only due to the chronology of their discovery. Here we focus on the cellular functions of the three class II PI3K isoforms, PI3KC2α, PI3KC2β, and PI3KC2γ, in different cell systems and underline the emerging importance of these enzymes in different physiological and pathological contexts. We provide an overview on the current development of class II PI3 kinase inhibitors and outline the potential use for such inhibitors. The field is in its infancy as compared to their class I counterparts. Nevertheless, recent advances in understanding the roles of class II PI3 kinases in different pathological contexts is leading to an increased interest in the development of specific inhibitors that can provide potential novel pharmacological tools.
authors.affiliation: Metabolic Signalling Group, School of Biomedical Sciences, CHIRI Biosciences, Curtin University , Perth, Western Australia 6845, Australia.
authors.forename: Marco
authors.initials: M
authors.lastname: Falasca
authors.affiliation: Australian Centre for Blood Diseases and Department of Clinical Haematology, Monash University , 99 Commercial Road, Melbourne, Victoria 3004, Australia.
authors.forename: Justin R
authors.initials: JR
authors.lastname: Hamilton
authors.affiliation: Australian Centre for Blood Diseases and Department of Clinical Haematology, Monash University , 99 Commercial Road, Melbourne, Victoria 3004, Australia.
authors.forename: Maria
authors.initials: M
authors.lastname: Selvadurai
authors.affiliation: Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus) , 381 Royal Parade, Parkville, Victoria 3052, Australia.
authors.forename: Krithika
authors.initials: K
authors.lastname: Sundaram
authors.affiliation: Metabolic Signalling Group, School of Biomedical Sciences, CHIRI Biosciences, Curtin University , Perth, Western Australia 6845, Australia.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Adamska
authors.affiliation: Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus) , 381 Royal Parade, Parkville, Victoria 3052, Australia.
authors.forename: Philip E
authors.initials: PE
authors.lastname: Thompson
mesh_terms: D000818:Animals; D004194:Disease; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D000081082:Phosphoinositide-3 Kinase Inhibitors
chemical_list: D004791:Enzyme Inhibitors; D000081082:Phosphoinositide-3 Kinase Inhibitors