title: Venous Thromboembolic Disease in Children and Adolescents.
abstract: The VTE is mainly a disease of the older adult, though its incidence has increased significantly in the pediatric population over the past several years. This trend is likely due to enhanced awareness and recognition of VTE, as well as increased prevalence of thromboembolic associated risk factors, such as increases in the proportion of children with predisposing medical conditions. The evaluation and management of a child with VTE is similar to that of adults, however pediatric patients have their own distinct aspects of care, stemming from particularities of the hemostatic system, age-related risk factors and differences in response to anticoagulant and antithrombotic therapy. This review addresses the risk factors and the evaluation and management of children with VTE.
authors.affiliation: Department of Pediatrics, University of Kentucky, KY Clinic J 453 740S Limestone St, Lexington, KY, 40536, USA. vlad.radulescu@uky.edu.
authors.forename: Vlad C
authors.initials: VC
authors.lastname: Radulescu
authors.affiliation: Department of Pediatrics, Markey Cancer Center, University of Kentucky, Combs Research Bldg. Rm. 204 800 Rose Street, Lexington, KY, 40536, USA.
authors.forename: John A
authors.initials: JA
authors.lastname: D'Orazio
mesh_terms: D000293:Adolescent; D000925:Anticoagulants / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D062905:Central Venous Catheters / Q000009:adverse effects; D002648:Child; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006330:Heart Defects, Congenital / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D009369:Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D012307:Risk Factors; D018805:Sepsis / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D013514:Surgical Procedures, Operative / Q000009:adverse effects; D017131:Thrombectomy; D013923:Thromboembolism / Q000175:diagnosis / Q000209:etiology / Q000601:surgery / Q000628:therapy*; D020246:Venous Thrombosis / Q000175:diagnosis / Q000209:etiology / Q000601:surgery / Q000628:therapy*
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents
keywords: Anticoagulant therapy; Children; Clotting; Inherited thrombophilia; Thromboembolism; Thrombolytic therapy