title: Generalized plasma skimming model for cells and drug carriers in the microvasculature.
abstract: In microvascular transport, where both blood and drug carriers are involved, plasma skimming has a key role on changing hematocrit level and drug carrier concentration in capillary beds after continuous vessel bifurcation in the microvasculature. While there have been numerous studies on modeling the plasma skimming of blood, previous works lacked in consideration of its interaction with drug carriers. In this paper, a generalized plasma skimming model is suggested to predict the redistributions of both the cells and drug carriers at each bifurcation. In order to examine its applicability, this new model was applied on a single bifurcation system to predict the redistribution of red blood cells and drug carriers. Furthermore, this model was tested at microvascular network level under different plasma skimming conditions for predicting the concentration of drug carriers. Based on these results, the applicability of this generalized plasma skimming model is fully discussed and future works along with the model's limitations are summarized.
authors.affiliation: Advanced Institutes of Convergence Technology, Seoul National University, Suwon, 443-270, Republic of Korea. taerinlee@snu.ac.kr.
authors.forename: Tae-Rin
authors.initials: TR
authors.lastname: Lee
authors.affiliation: Advanced Institutes of Convergence Technology, Seoul National University, Suwon, 443-270, Republic of Korea.
authors.forename: Sung Sic
authors.initials: SS
authors.lastname: Yoo
authors.affiliation: Advanced Institutes of Convergence Technology, Seoul National University, Suwon, 443-270, Republic of Korea.|Department of Computer Science, Technische Universität München, Boltzmannstraße 3, Garching, Germany.
authors.forename: Jiho
authors.initials: J
authors.lastname: Yang
mesh_terms: D004337:Drug Carriers / Q000032:analysis / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D008833:Microcirculation / Q000502:physiology*; D055806:Microvessels / Q000378:metabolism; D008954:Models, Biological; D010949:Plasma / Q000737:chemistry / Q000378:metabolism*
chemical_list: D004337:Drug Carriers
keywords: Drug carrier; Microvascular transport; Nanomedicine; Plasma skimming