title: [Current Status of Translational Research on Irritable Bowel Syndrome].
abstract: Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. The pathophysiology of IBS is not completely understood. Genetic, immune, environmental, inflammatory, neurological and psychological factors contribute to the risk of this condition. Traditional research explored gastrointestinal motor abnormalities, central neural dysregulation, abnormal psychological features, and visceral hypersensitivity. More recent investigations consider bacterial overgrowth, abnormal serotonin pathways, altered gut flora, immune activation and mucosal inflammation. The purpose of this article is to review recent translational research concerning the pathophysiology, biomarker and genetic factors of IBS and to encourage IBS research in Korea.
authors.affiliation: Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Yong Hwan
authors.initials: YH
authors.lastname: Kwon
authors.affiliation: Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea.
authors.forename: Hyun Jin
authors.initials: HJ
authors.lastname: Kim
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D002169:Campylobacter Infections / Q000150:complications / Q000175:diagnosis / Q000382:microbiology; D016207:Cytokines / Q000097:blood; D004195:Disease Models, Animal; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology; D057170:Translational Research, Biomedical
chemical_list: D015415:Biomarkers; D016207:Cytokines
keywords: Biomarkers; Genetic; Irritable bowel syndrome; Physiopathology; Translational medical research