title: Extreme Hyperferritinemia in Dizygotic Twins With Human Parechovirus-3 Infection.
abstract: Human parechovirus-3 has been associated with severe clinical manifestations in infants, such as sepsis-like illness and meningoencephalitis. Nevertheless, the vast majority of patients have a favorable outcome. We report the occurrence of this infection in dizygotic infants with extreme hyperferritinemia and a transient impairment of natural killer cell cytotoxicity.
authors.affiliation: From the *Pediatrics Department, and †Molecular Microbiology Department, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain; ‡Pediatric Infectious Diseases Research Group, Institut de Recerca Pediàtrica Hospital Sant Joan de Déu, Barcelona, Spain; CIBER Epidemiología y Salud Pública CIBERESP, Health Institute "Carlos III", Madrid, Spain; §Enterovirus Unit, National Centre for Microbiology, Health Institute "Carlos III", Madrid, Spain; and ¶Allergy and Clinical Immunology Department, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain.
authors.forename: Dídac
authors.initials: D
authors.lastname: Casas-Alba
authors.forename: Antonio
authors.initials: A
authors.lastname: Martínez-Monseny
authors.forename: Laura
authors.initials: L
authors.lastname: Monfort
authors.forename: Carmen
authors.initials: C
authors.lastname: Muñoz-Almagro
authors.forename: María
authors.initials: M
authors.lastname: Cabrerizo
authors.forename: Àngela
authors.initials: À
authors.lastname: Deyà
authors.forename: Cristian
authors.initials: C
authors.lastname: Launes
mesh_terms: D005260:Female; D006801:Humans; D007223:Infant; D019189:Iron Metabolism Disorders; D051359:Lymphohistiocytosis, Hemophagocytic; D008297:Male; D030061:Parechovirus; D010850:Picornaviridae Infections; D014429:Twins, Dizygotic