title: Metabolic pathways in the periphery and brain: Contribution to mental disorders?
abstract: The association between mental disorders and diabetes has a long history. Recent large-scale, well-controlled epidemiological studies confirmed a link between diabetes and psychiatric illnesses. The scope of this review is to summarize our current understanding of this relationship from a molecular perspective. We first discuss the potential contribution of diabetes-associated metabolic impairments to the etiology of mental conditions. Then, we focus on possible shared molecular risk factors and mechanisms. Simple comorbidity, shared susceptibility loci, and common pathophysiological processes in diabetes and mental illnesses have changed our traditional way of thinking about mental illness. We conclude that schizophrenia and affective disorders are not limited to an imbalance in dopaminergic and serotoninergic neurotransmission in the brain. They are also systemic disorders that can be considered, to some extent, as metabolic disorders.
authors.affiliation: Laboratory of Molecular Neurobiology, Centre of New Technologies, University of Warsaw, 02-097 Warsaw, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Nagalski
authors.affiliation: Laboratory of Molecular Neurobiology, Centre of New Technologies, University of Warsaw, 02-097 Warsaw, Poland.
authors.forename: Kamil
authors.initials: K
authors.lastname: Kozinski
authors.affiliation: Laboratory of Molecular Neurobiology, Centre of New Technologies, University of Warsaw, 02-097 Warsaw, Poland. Electronic address: m.wisniewska@uw.edu.pl.
authors.forename: Marta B
authors.initials: MB
authors.lastname: Wisniewska
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D001523:Mental Disorders / Q000453:epidemiology / Q000378:metabolism*; D053858:Metabolic Networks and Pathways
chemical_list: D005947:Glucose
keywords: Diabetes; Genetic risk factors; Insulin; Metabolism; Serious mental disorders