title: Endometrial carcinoma-related genetic factors: application to research and clinical practice in China.
abstract: Genetic factors affect the initiation and progression of endometrial carcinoma (EC). The routine detection of genetic factors involved in EC has not been extensively performed in Chinese clinical practice, however. In this review we summarise EC-related genetic factors, including Lynch syndrome-associated mutations and non-Lynch syndrome-associated genetic predispositions found in Chinese women, and their potential clinical applications. In addition, we propose a clinical testing strategy for patients with EC and their family members. The objective of this review is to advance basic research regarding the genetic factors involved in EC and to improve its clinical implementation in China.
  
  
  CONCLUSIONS
  Review summarises Chinese research progression of EC-related genetic factors and proposes innovative screening strategy.
authors.affiliation: Department of Obstetrics and Gynaecology, Peking University People's Hospital, Beijing, China.
authors.forename: J Y
authors.initials: JY
authors.lastname: Zhou
authors.affiliation: Prenatal Diagnosis Centre, Peking University People's Hospital, Beijing, China.
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics and Gynaecology, Peking University People's Hospital, Beijing, China.
authors.forename: L H
authors.initials: LH
authors.lastname: Wei
authors.affiliation: Department of Obstetrics and Gynaecology, Peking University People's Hospital, Beijing, China. wangjianliu@pkuph.edu.cn, wangjianliu1203@163.com.
authors.forename: J L
authors.initials: JL
authors.lastname: Wang
mesh_terms: D044466:Asian People / Q000235:genetics; D035843:Biomedical Research; D002681:China / Q000453:epidemiology; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D004252:DNA Mutational Analysis; D018450:Disease Progression; D055088:Early Detection of Cancer / Q000379:methods*; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D005820:Genetic Testing / Q000639:trends*; D006801:Humans; D020641:Polymorphism, Single Nucleotide
keywords: Endometrial carcinoma; Lynch syndrome; genetic factors; polymorphism; risk factors; single-nucleotide epigenetics