title: Cerebrovascular complications of diabetes: focus on cognitive dysfunction.
abstract: The incidence of diabetes has more than doubled in the United States in the last 30 years and the global disease rate is projected to double by 2030. Cognitive impairment has been associated with diabetes, worsening quality of life in patients. The structural and functional interaction of neurons with the surrounding vasculature is critical for proper function of the central nervous system including domains involved in learning and memory. Thus, in this review we explore cognitive impairment in patients and experimental models, focusing on links to vascular dysfunction and structural changes. Lastly, we propose a role for the innate immunity-mediated inflammation in neurovascular changes in diabetes.
authors.affiliation: Department of Physiology, Medical College of Georgia, Augusta University, Augusta, GA 30912, U.S.A.
authors.forename: Trevor
authors.initials: T
authors.lastname: Hardigan
authors.affiliation: Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, U.S.A.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Ward
authors.affiliation: Department of Physiology, Medical College of Georgia, Augusta University, Augusta, GA 30912, U.S.A. Charlie Norwood Veterans Administration Medical Center, Augusta, GA 30912, U.S.A. aergul@augusta.edu.
authors.forename: Adviye
authors.initials: A
authors.lastname: Ergul
mesh_terms: D000818:Animals; D002561:Cerebrovascular Disorders / Q000209:etiology / Q000523:psychology*; D003071:Cognition; D048909:Diabetes Complications / Q000209:etiology / Q000276:immunology / Q000523:psychology*; D003920:Diabetes Mellitus / Q000235:genetics / Q000276:immunology; D006801:Humans; D011788:Quality of Life
keywords: cerebral vasculature; cognitive impairment; diabetes; vascular