title: Correlating Corneal Biomechanics and Ocular Biometric Properties with Lamina Cribrosa Measurements in Healthy Subjects.
abstract: OBJECTIVE
  To examine interrelations between corneal biomechanics, ocular biometric variables and optic disc size (ODS), lamina cribosa depth (LCD) or thickness (LCT) in a healthy population.
  
  
  METHODS
  In a cross-sectional case-control study, the following measurements were made in 81 eyes of 81 participants: axial length, anterior chamber depth, lens thickness, and central corneal thickness using the optical biometer Lenstar LS900; and corneal hysteresis (CH), corneal resistance factor (CRF), Goldman-correlated intraocular pressure (IOPg), and corneal-compensated IOP (IOPcc) using the Ocular Response Analyzer. Serial horizontal enhanced depth imaging optical coherence tomography (EDI OCT) B-scans of the optic nerve head were obtained in each participant. Mean ODS, mean LCD, and mean LCT were measured in 11 equally spaced horizontal B-scans, excluding the LC insertion area under Bruch's membrane and scleral rim.
  
  
  RESULTS
  LCD was measured in 74 of 81 eyes (91.36%); LCT in 60/81 (75.3%); ODS in 81/81 (100%). CRF was poorly, but significantly, correlated with LCT (Pearson's R = 0.264; P = 0.045). IOPcc, IOPg, CH, and ocular biometrics variables were poorly (non-significantly) correlated with LCD, LCT, and ODS.
  
  
  CONCLUSIONS
  CRF was poorly but directly correlated with LCT. No association was detected between CH or ocular biometric variables and ODS, LCD, or LCT.
authors.affiliation: a Hospital Clinico Universitario San Carlos , Ophthalmology , Profesor Martín Lagos S/N, Madrid , Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Pérez Bartolomé
authors.affiliation: a Hospital Clinico Universitario San Carlos , Ophthalmology , Profesor Martín Lagos S/N, Madrid , Spain.
authors.forename: Jose María
authors.initials: JM
authors.lastname: Martínez de la Casa
authors.affiliation: a Hospital Clinico Universitario San Carlos , Ophthalmology , Profesor Martín Lagos S/N, Madrid , Spain.
authors.forename: Irene
authors.initials: I
authors.lastname: Camacho Bosca
authors.affiliation: a Hospital Clinico Universitario San Carlos , Ophthalmology , Profesor Martín Lagos S/N, Madrid , Spain.
authors.forename: Federico
authors.initials: F
authors.lastname: Sáenz-Francés
authors.affiliation: a Hospital Clinico Universitario San Carlos , Ophthalmology , Profesor Martín Lagos S/N, Madrid , Spain.
authors.forename: Soledad
authors.initials: S
authors.lastname: Aguilar Munoa
authors.affiliation: a Hospital Clinico Universitario San Carlos , Ophthalmology , Profesor Martín Lagos S/N, Madrid , Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Martín Juan
authors.affiliation: a Hospital Clinico Universitario San Carlos , Ophthalmology , Profesor Martín Lagos S/N, Madrid , Spain.
authors.forename: Julian
authors.initials: J
authors.lastname: Garcia-Feijoo
mesh_terms: D000328:Adult; D001699:Biometry; D016022:Case-Control Studies; D003315:Cornea / Q000000981:diagnostic imaging / Q000502:physiology*; D003430:Cross-Sectional Studies; D004548:Elasticity; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000000981:diagnostic imaging*; D041623:Tomography, Optical Coherence / Q000379:methods; D014065:Tonometry, Ocular; D014794:Visual Fields; D055815:Young Adult
keywords: Central corneal thickness; corneal hysteresis; corneal resistance factor; lamina cribrosa depth; lamina cribrosa thickness