title: The Intrinsic Pathway of Coagulation as a Target for Antithrombotic Therapy.
abstract: Plasma coagulation in the activated partial thromboplastin time assay is initiated by sequential activation of coagulation factors XII, XI, and IX. While this series of proteolytic reactions is not an accurate model for hemostasis in vivo, there is mounting evidence that factor XI and factor XII contribute to thrombosis, and that inhibiting them can produce an antithrombotic effect with a small effect on hemostasis. This article discusses the contributions of components of the intrinsic pathway to thrombosis in animal models and humans, and results of early clinical trials of drugs targeting factors IX, XI, and XII.
authors.affiliation: Department of Pathology, Microbiology and Immunology, Vanderbilt University, C-3321A Medical Center North, 1161 21st Avenue, Nashville, TN 37232, USA; Department of Pediatrics, Vanderbilt University, 397 Preston Research Building, 2220 Pierce Ave, Nashville, TN 37232, USA. Electronic address: allison.p.wheeler@vanderbilt.edu.
authors.forename: Allison P
authors.initials: AP
authors.lastname: Wheeler
authors.affiliation: Department of Pathology, Microbiology and Immunology, Vanderbilt University, C-3321A Medical Center North, 1161 21st Avenue, Nashville, TN 37232, USA; Hematology/Oncology Division, Department of Medicine, Vanderbilt University, 777 Preston Research Building, 2220 Pierce Avenue, Nashville, TN 37232, USA.
authors.forename: David
authors.initials: D
authors.lastname: Gailani
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D001779:Blood Coagulation Factors / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D010314:Partial Thromboplastin Time; D013927:Thrombosis / Q000097:blood* / Q000188:drug therapy*
chemical_list: D001779:Blood Coagulation Factors
keywords: Contact activation; Factor XI; Factor XII; Intrinsic pathway; Thrombosis