title: Guidelines for the Management of Severe Traumatic Brain Injury, Fourth Edition.
abstract: The scope and purpose of this work is 2-fold: to synthesize the available evidence and to translate it into recommendations. This document provides recommendations only when there is evidence to support them. As such, they do not constitute a complete protocol for clinical use. Our intention is that these recommendations be used by others to develop treatment protocols, which necessarily need to incorporate consensus and clinical judgment in areas where current evidence is lacking or insufficient. We think it is important to have evidence-based recommendations to clarify what aspects of practice currently can and cannot be supported by evidence, to encourage use of evidence-based treatments that exist, and to encourage creativity in treatment and research in areas where evidence does not exist. The communities of neurosurgery and neuro-intensive care have been early pioneers and supporters of evidence-based medicine and plan to continue in this endeavor. The complete guideline document, which summarizes and evaluates the literature for each topic, and supplemental appendices (A-I) are available online at https://www.braintrauma.org/coma/guidelines.
authors.affiliation: Oregon Health & Science University, Portland, Oregon.
authors.forename: Nancy
authors.initials: N
authors.lastname: Carney
authors.affiliation: Oregon Health & Science University, Portland, Oregon.
authors.forename: Annette M
authors.initials: AM
authors.lastname: Totten
authors.affiliation: Oregon Health & Science University, Portland, Oregon.
authors.forename: Cindy
authors.initials: C
authors.lastname: O'Reilly
authors.affiliation: Hofstra North Shore-LIJ School of Medicine, Hempstead, New York.
authors.forename: Jamie S
authors.initials: JS
authors.lastname: Ullman
authors.affiliation: University of Utah, Salt Lake City, Utah.
authors.forename: Gregory W J
authors.initials: GW
authors.lastname: Hawryluk
authors.affiliation: University of Pittsburgh, Pittsburgh, Pennsylvania.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Bell
authors.affiliation: University of Utah, Salt Lake City, Utah.
authors.forename: Susan L
authors.initials: SL
authors.lastname: Bratton
authors.affiliation: University of Washington, Seattle, Washington.
authors.forename: Randall
authors.initials: R
authors.lastname: Chesnut
authors.affiliation: Stanford University, Stanford, California.
authors.forename: Odette A
authors.initials: OA
authors.lastname: Harris
authors.affiliation: University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Niranjan
authors.initials: N
authors.lastname: Kissoon
authors.affiliation: El Bosque University, Bogota, Colombia.|MEDITECH Foundation, Neiva, Colombia.
authors.forename: Andres M
authors.initials: AM
authors.lastname: Rubiano
authors.affiliation: University of Pittsburgh, Pittsburgh, Pennsylvania.
authors.forename: Lori
authors.initials: L
authors.lastname: Shutter
authors.affiliation: Harvard Medical School & Boston Children's Hospital, Boston, Massachusetts.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Tasker
authors.affiliation: University of Washington, Seattle, Washington.
authors.forename: Monica S
authors.initials: MS
authors.lastname: Vavilala
authors.affiliation: Drexel University, Pittsburgh, Pennsylvania.
authors.forename: Jack
authors.initials: J
authors.lastname: Wilberger
authors.affiliation: Emory University, Atlanta, Georgia.
authors.forename: David W
authors.initials: DW
authors.lastname: Wright
authors.affiliation: Stanford University, Stanford, California.
authors.forename: Jamshid
authors.initials: J
authors.lastname: Ghajar
mesh_terms: D000070642:Brain Injuries, Traumatic / Q000628:therapy*; D003422:Critical Care; D019317:Evidence-Based Medicine; D006801:Humans; D019635:Neurosurgical Procedures; D017410:Practice Guidelines as Topic
keywords: Adults; Critical care; Evidence-based medicine; Guidelines; Severe traumatic brain injury; Systematic review