title: Usefulness of thyroglobulin in cervical lymph node fine-needle aspirations at initial thyroidectomy for the diagnosis of metastases in papillary thyroid cancer.
abstract: OBJECTIVE
  To study the role of fine-needle aspiration biopsy and thyroglobulin measurement (FNAB-Tg) in diagnosing cervical lymph node (CLN) metastases in patients with papillary thyroid cancer (PTC) before thyroidectomy.
  
  
  METHODS
  Ultrasonography (US)-guided FNAB was performed on 92 patients with PTCs with 105 CLNs before surgery. The wash-out of the FNAB-Tg level was detected.
  
  
  RESULTS
  Based on the final pathology, 67 lymph nodes (LNs) were positive for metastasis, and 38 LNs were negative for metastasis. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of FNAB-Tg in thyroidectomized patients was 100%, 86.8%, 95.2%, 97.3%, and 95.2%, respectively.
  
  
  CONCLUSIONS
  FNAB-Tg is a useful technique for diagnosing CLN metastasis of PTC before thyroidectomy. .
authors.forename: Jing
authors.initials: J
authors.lastname: Yu
authors.forename: Yanpeng
authors.initials: Y
authors.lastname: Song
authors.forename: Zhirong
authors.initials: Z
authors.lastname: Jiang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D002291:Carcinoma, Papillary / Q000737:chemistry / Q000473:pathology* / Q000556:secondary* / Q000601:surgery; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000737:chemistry; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*; D013954:Thyroglobulin / Q000032:analysis*; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D013965:Thyroidectomy; D018084:Ultrasonography, Interventional; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D013954:Thyroglobulin