title: Clinical features and outcomes of diffuse endocapillary proliferation Henoch-Schönlein purpura nephritis in children.
abstract: OBJECTIVE
  To investigate the outcomes of childhood diffuse endocapillary proliferation Henoch-Schönlein purpura nephritis (DEP-HSPN) in response to early diagnosis and prompt treatment.
  
  
  METHODS
  Eleven cases of DEP-HSPN in children were investigated in comparison to HSPN without diffuse endocapillary proliferation (non-DEP-HSPN).
  
  
  RESULTS
  DEP-HSPN had a higher prevalence of nephrotic syndrome but a lower prevalence of hematuria compared to non-DEP-HSPN. IgA, IgG and IgM antibody deposition was found in DEP-HSPN by histopathological examination. Proteinuria cleared in all 11 cases through treatment with steroids and/or immunosuppressive drugs. However, half of the DEP-HSPN patients continuously had hematuria after treatment.
  
  
  CONCLUSIONS
  The early diagnosis and prompt initiation of immunosuppressive treatment based on renal biopsy are important for achieving favorable outcomes.
authors.affiliation: The Children's Hospital of Zhejiang University School of Medicine, Department of Nephrology, Hangzhou 310003, China.
authors.forename: Haidong
authors.initials: H
authors.lastname: Fu
authors.affiliation: The Children's Hospital of Zhejiang University School of Medicine, Department of Nephrology, Hangzhou 310003, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Mao
authors.affiliation: The Children's Hospital of Zhejiang University School of Medicine, Department of Nephrology, Hangzhou 310003, China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Xu
authors.affiliation: The Children's Hospital of Zhejiang University School of Medicine, Department of Nephrology, Hangzhou 310003, China.
authors.forename: Weizhong
authors.initials: W
authors.lastname: Gu
authors.affiliation: The Children's Hospital of Zhejiang University School of Medicine, Department of Nephrology, Hangzhou 310003, China.
authors.forename: Xiujuan
authors.initials: X
authors.lastname: Zhu
authors.affiliation: The Children's Hospital of Zhejiang University School of Medicine, Department of Nephrology, Hangzhou 310003, China.
authors.forename: Aimin
authors.initials: A
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006417:Hematuria; D006801:Humans; D011695:IgA Vasculitis / Q000188:drug therapy* / Q000473:pathology*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007668:Kidney / Q000473:pathology; D008297:Male; D009393:Nephritis / Q000188:drug therapy* / Q000473:pathology*; D011241:Prednisone / Q000627:therapeutic use; D011507:Proteinuria; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D011241:Prednisone