title: SNAP-25 gene variations and attention-deficit hyperactivity disorder in Iranian population.
abstract: OBJECTIVE
  Attention deficit hyperactivity disorder (ADHD) is a common psychiatric condition of childhood characterized by persistent symptoms of hyperactivity, inattention, and impulsivity. The objective of this study was to investigate the association of synaptosomal-associated protein of 25 kDa (SNAP-25) gene variants with ADHD.
  
  
  METHODS
  A case-control study with a total of 150 children with ADHD (mean age 9.61; range 6-16; gender ratio 105m/45f) and 150 normal children (mean age 10.02; range 6-16; gender ratio 98m/52f) was conducted. Genomic DNA was extracted from peripheral blood of all samples and SNPs rs78428954 and rs3746544 located in SNAP-25 gene were genotyped.
  
  
  RESULTS
  Our analysis indicated that there is no significant association between none of studied variants in SNAP-25 and ADHD.
  
  
  CONCLUSIONS
  To our knowledge, it is the first report of SNAP-25 genotyping in Iranian patients with ADHD. Further investigations with larger populations are needed in order to clarify the exact role of SNAP-25 variations in susceptibility to ADHD.
authors.affiliation: a Faculty of Basic Sciences, Department of Biology, Shahrekord Branch , Islamic Azad University , Shahrekord , Iran.
authors.forename: Mahjoubeh
authors.initials: M
authors.lastname: Zarrabi Alhosseini
authors.affiliation: b Noncommunicable Diseases Research Center , Fasa University of Medical Sciences , Fasa , Iran.
authors.forename: Javad
authors.initials: J
authors.lastname: Jamshidi
authors.affiliation: c Molecular Immunology Research Center , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Zare Bidoki
authors.affiliation: d Mehr Hospital , Mashhad University of Medical Sciences , Mashhad , Iran.
authors.forename: Saeid
authors.initials: S
authors.lastname: Ganji
authors.affiliation: e Department of Psychiatry, Imam Hossein Medical Hospital , Shahid Behashti University of Medical Sciences , Tehran , Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Eslami Amirabadi
authors.affiliation: f Department of Medical Genetics , School of Medicine, Shahid Beheshti University of Medical Sciences , Tehran , Iran.
authors.forename: Babak
authors.initials: B
authors.lastname: Emamalizadeh
authors.affiliation: f Department of Medical Genetics , School of Medicine, Shahid Beheshti University of Medical Sciences , Tehran , Iran.
authors.forename: Shaghayegh
authors.initials: S
authors.lastname: Taghavi
authors.affiliation: g Tehran Medical Sciences Branch , Islamic Azad University , Tehran , Iran.
authors.forename: Parasto
authors.initials: P
authors.lastname: Shokraeian
authors.affiliation: h Advanced Science & Technology Faculty , Tehran Medical Branch, Islamic Azad University , Tehran , Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Mohajerani
authors.affiliation: f Department of Medical Genetics , School of Medicine, Shahid Beheshti University of Medical Sciences , Tehran , Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Darvish
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D001289:Attention Deficit Disorder with Hyperactivity / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017678:Sex Distribution; D050825:Synaptosomal-Associated Protein 25
chemical_list: D050825:Synaptosomal-Associated Protein 25
keywords: ADHD; Iranian; Polymorphism; SNAP-25; Variation