title: Comparison of Effects of Propofol and Isosorbide Dinitrate during Rewarming on Cardiopulmonary Bypass.
abstract: OBJECTIVE
  Comparison of effects of propofol and isosorbide dinitrate during rewarming on cardiopulmonary bypass in patients undergoing coronary artery bypasses grafting.
  
  
  METHODS
  It was randomized prospective clinical trial. One hundred and twenty patient (120) undergoing CABG surgery were included in this study. Group-I (Study group, n=60): in which only propofol infusion used during rewarming and Group-II (control Group, n=60) in which isosorbide dinitrate and propofol infusion combination was used during rewarming. The data was entered and analyzed through SPSS Version 19. Independent sample T-test and chi-square test were used for data analysis. P value of ≤ 0.05 was taken as significant.
  
  
  RESULTS
  Mean arterial pressures during rewarming were 63.41±3.61 mmHg in propofol group versus 60.80±4.86 mmHg in control group (p-value 0.001). Core temperature on weaning from cardiopulmonary bypass was 37.11±0.49 °C in propofol group and 37.00±0.18 °C in control group. After drop in core temperature was little more in propofol group (1.02±0.36 °C) versus 0.96±0.37 °C in control group but this difference was not statistically significant (p-value 0.41). Mean Ventilation time after surgery in propofol group was 4.65±0.65 hours versus 5.03±0.81 hours in control group (p-value 0.006).
  
  
  CONCLUSIONS
  Propofol alone is capable of fulfilling the requirements of adequate rewarming during Cardiopulmonary bypass and can produce more hemodynamic stability and early post-operative recovery.
authors.affiliation: Dr. Aamir Furqan, FCPS. Assistant Professor, Department of Anesthesia, Multan Institute of Kidney Diseases, Multan - Pakistan.
authors.forename: Aamir
authors.initials: A
authors.lastname: Furqan
authors.affiliation: Dr. Sohail Ahmad, FCPS. M.Sc Pain Medicine, Assistant Professor of Anesthesia, Ch. Pervaiz Elahi Institute of Cardiology, Multan, Pakistan.
authors.forename: Sohail
authors.initials: S
authors.lastname: Ahmad
authors.affiliation: Dr. Liaqat Ali, FCPS. Assistant Professor of Anesthesia, Multan Medical and Dental College, Multan, Pakistan.
authors.forename: Liaqat
authors.initials: L
authors.lastname: Ali
authors.affiliation: Dr. Rahat Akhtar, MBBS. Woman Medical Officer, Nishter Hospital Multan, Pakistan.
authors.forename: Rahat
authors.initials: R
authors.lastname: Akhtar
authors.affiliation: Mr. Mirza Ahmad Raza Baig, B.Sc Hons. Cardiac Perfusion. Clinical Perfusionist.
authors.forename: Mr Mirza Ahmad Raza
authors.initials: MM
authors.lastname: Baig
authors.affiliation: Prof. Rana Altaf, FCPS, FICS, Professor of Anesthesia, Chief Anesthetist, Ch. Pervaiz Elahi Institute of Cardiology, Multan, Pakistan.
authors.forename: Rana
authors.initials: R
authors.lastname: Altaf
keywords: Cardiopulmonary Bypass; Isosorbide Dinitrate; Propofol