title: Usefulness of chemoradiotherapy for inoperable gastric cancer.
abstract: Introduction Radiotherapy is not commonly used for the treatment of gastric cancer in Japan, where surgery is the standard local treatment. We report the results of chemoradiotherapy in patients with advanced or recurrent gastric cancer which was deemed difficult to treat surgically. Methods Twenty-one patients with gastric cancer (including sixteen with advanced/recurrent gastric cancer and five with poor general condition) underwent chemo-radiotherapy, for whom the therapeutic efficacy, toxicity and survival period were analysed. Results The tumour response to chemoradiotherapy was categorised as complete, partial, stable or progressive in 5, 9, 3, and 4 patients, respectively, with an overall response rate of 67%. No serious complications such as gastrointestinal perforation or bleeding occurred, and no cardiac, hepatic or renal dysfunction developed during the follow-up period. The mean survival time was 19.8 months (range, 3-51 months). One patient died of another disease, 18 died of primary cancer and the cause of death was unknown in 2 patients. Conclusions Chemoradiotherapy appears to be an effective treatment for localised gastric cancer without distant metastases, but further studies are needed to determine the indications for chemoradiotherapy and late adverse effects, as well as the chemotherapy regimens to be used.
authors.affiliation: Department of Surgery, Jikei University Daisan Hospital , Tokyo , Japan.
authors.forename: T
authors.initials: T
authors.lastname: Taki
authors.affiliation: Department of Surgery, Jikei University Daisan Hospital , Tokyo , Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hoya
authors.affiliation: Department of Surgery, Jikei University Daisan Hospital , Tokyo , Japan.
authors.forename: A
authors.initials: A
authors.lastname: Watanabe
authors.affiliation: Department of Surgery, Jikei University Daisan Hospital , Tokyo , Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakayoshi
authors.affiliation: Department of Surgery, Jikei University Daisan Hospital , Tokyo , Japan.
authors.forename: T
authors.initials: T
authors.lastname: Okamoto
authors.affiliation: Department of Radiology, Jikei University Daisan Hospital , Tokyo , Japan.
authors.forename: H
authors.initials: H
authors.lastname: Sekine
authors.affiliation: Department of Radiology, Jikei University Daisan Hospital , Tokyo , Japan.
authors.forename: N
authors.initials: N
authors.lastname: Mitsumori
authors.affiliation: Department of Surgery, Jikei University School of Medicine , Tokyo , Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yanaga
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000628:therapy*; D000368:Aged; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D059248:Chemoradiotherapy; D002945:Cisplatin / Q000008:administration & dosage; D004338:Drug Combinations; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007564:Japan; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000628:therapy*; D010094:Oxonic Acid / Q000627:therapeutic use*; D020266:Radiotherapy, Conformal / Q000379:methods*; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology / Q000628:therapy*; D015996:Survival Rate; D005641:Tegafur / Q000627:therapeutic use*
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin; D005472:Fluorouracil
keywords: Advanced gastric cancer; Chemo-radiation therapy; Non-curative resection; Recurrent gastric cancer