title: The Number of Stenotic Intracranial Arteries Is Independently Associated with Ischemic Stroke Severity.
abstract: BACKGROUND
  The severity of ischemic stroke symptoms varies among patients and is a critical determinant of patient outcome. To date, the association between the number of stenotic intracranial arteries and stroke severity remains unclear.
  
  
  OBJECTIVE
  We aimed to investigate the association between the number of stenotic major intracranial arteries (NSMIA) and ischemic stroke severity, as well as the degree of stenosis and common stroke risk factors.
  
  
  METHODS
  We performed a retrospective analysis of patients with digital subtraction angiography (DSA)-confirmed ischemic stroke. Clinical stroke severity was measured using the National Institutes of Health Stroke Scale (NIHSS). The number of stenotic vessels was counted from the internal carotid arteries and vertebral arteries, bilaterally.
  
  
  RESULTS
  Eighty three patients were recruited from a single center and included in the study. NSMIA was significantly correlated with stroke severity (Pearson Correlation Coefficient = 0.485, P < 0.001), but not with the degree of stenosis (Pearson Correlation Coefficient = 0.01, P = 0.90). Multivariate regression analysis revealed that NSMIA was significantly associated with the NIHSS score after adjusting for stroke risk factors. The adjusted odds ratio (per lateral) was 2.092 (95% CI, 0.865 to 3.308, P = 0.001). The degree of stenosis was also significantly associated with the NIHSS score after adjusting for common risk factors. The odds ratio (per 10%) was 0.712 (95% CI, 0.202 to 1.223, P = 0.007).
  
  
  CONCLUSIONS
  The number of stenotic intracranial major arteries is associated with the severity of ischemic stroke independent of the degree of stenosis and other stroke risk factors. To the best of our knowledge, this has not been previosuly studied in great detail using DSA. Our data highlight the importance of examining all major arteries in stroke patients.
authors.affiliation: Medicine and Pharmaceutics Research Center, Binzhou Medical University, Yantai, Shandong, China.
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Wei
authors.affiliation: Department of Clinical Imaging, Affiliated Hospital, Binzhou Medical University, Binzhou, Shandong, China.
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Medicine and Pharmaceutics Research Center, Binzhou Medical University, Yantai, Shandong, China.
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.affiliation: Medicine and Pharmaceutics Research Center, Binzhou Medical University, Yantai, Shandong, China.
authors.forename: Chunhua
authors.initials: C
authors.lastname: Yang
authors.affiliation: Department of Clinical Imaging, Affiliated Hospital, Binzhou Medical University, Binzhou, Shandong, China.
authors.forename: Wenming
authors.initials: W
authors.lastname: Wang
authors.affiliation: Medicine and Pharmaceutics Research Center, Binzhou Medical University, Yantai, Shandong, China.
authors.forename: Xianglin
authors.initials: X
authors.lastname: Li
authors.affiliation: Medicine and Pharmaceutics Research Center, Binzhou Medical University, Yantai, Shandong, China.
authors.forename: Shuping
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Medicine and Pharmaceutics Research Center, Binzhou Medical University, Yantai, Shandong, China.
authors.forename: Xuri
authors.initials: X
authors.lastname: Li
authors.affiliation: Medicine and Pharmaceutics Research Center, Binzhou Medical University, Yantai, Shandong, China.
authors.forename: Geng
authors.initials: G
authors.lastname: Tian
authors.affiliation: Department of Chemistry-BMC and SciLifeLab, Analytical Chemistry, Uppsala University, Uppsala, Sweden.
authors.forename: Jonas
authors.initials: J
authors.lastname: Bergquist
authors.affiliation: Medicine and Pharmaceutics Research Center, Binzhou Medical University, Yantai, Shandong, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.affiliation: Medicine and Pharmaceutics Research Center, Binzhou Medical University, Yantai, Shandong, China.|Department of Chemistry-BMC and SciLifeLab, Analytical Chemistry, Uppsala University, Uppsala, Sweden.
authors.forename: Jia
authors.initials: J
authors.lastname: Mi
mesh_terms: D000328:Adult; D000368:Aged; D015901:Angiography, Digital Subtraction; D002545:Brain Ischemia / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D003251:Constriction, Pathologic / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D020765:Intracranial Arterial Diseases / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D020521:Stroke / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D055815:Young Adult