title: miR-15/miR-16 loss, miR-21 upregulation, or deregulation of their target genes predicts poor prognosis in prostate cancer patients.
abstract: It is clear that several prostate cancers remain indolent whereas others develop into advanced forms. There is a need to improve patient management by identifying biomarkers for personalized treatment. We demonstrated that miR-15/miR-16 loss, miR-21 upregulation, and deregulation of their target genes represent a promising predictive signature of poor patient prognosis.
authors.affiliation: Department of Hematology, Oncology and Molecular Medicine, Instituto Superiore di Sanità, Rome, Italy; Scientific Directorate, Regina Elena National Cancer Institute, Rome, Italy.
authors.forename: Désirée
authors.initials: D
authors.lastname: Bonci
authors.affiliation: Scientific Directorate, Regina Elena National Cancer Institute , Rome, Italy.
authors.forename: Ruggero
authors.initials: R
authors.lastname: De Maria
keywords: Metastases; Prostate cancer; miRNA