title: Obesity, Type 1 Diabetes, and Psoriasis: An Autoimmune Triple Flip.
abstract: Obesity, type 1 diabetes, and psoriasis are wide-ranging health problems. Genetics, epigenetics, and environmental factors together with immune disturbances are involved in these diseases. The white adipose tissue is an active endocrine organ, secreting a wide variety of soluble mediators called adipokines that have a central role in the relationship between adipose tissue and immune system. Inflammatory cytokines, including the IL-23/IL-17 and IL-18 axes, and microRNAs are involved in many processes, including immunity and inflammation, thus having a major role in the onset of these three diseases. In this review, we present an overview of the roles of adipokines, cytokines, and microRNAs in the pathogenesis and the progression of these three diseases.
authors.affiliation: Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
authors.forename: Mariagrazia
authors.initials: M
authors.lastname: Granata
authors.forename: Evangelia
authors.initials: E
authors.lastname: Skarmoutsou
authors.forename: Chiara
authors.initials: C
authors.lastname: Trovato
authors.forename: Giulio A
authors.initials: GA
authors.lastname: Rossi
authors.forename: Maria Clorinda
authors.initials: MC
authors.lastname: Mazzarino
authors.forename: Fabio
authors.initials: F
authors.lastname: D'Amico
mesh_terms: D054392:Adipokines / Q000276:immunology; D052436:Adipose Tissue, White / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology*; D016207:Cytokines / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D006801:Humans; D035683:MicroRNAs / Q000276:immunology; D009765:Obesity / Q000276:immunology*; D011565:Psoriasis / Q000276:immunology*
chemical_list: D054392:Adipokines; D016207:Cytokines; D035683:MicroRNAs