title: Accelerated skin wound healing using electrospun nanofibrous mats blended with mussel adhesive protein and polycaprolactone.
abstract: Nanofibrous scaffolds have been assessed as one of many promising tissue engineering scaffolds to be utilized for wound-healing applications. Previously, we reported multi-functionalized electrospun nanofibrous scaffolds blended with mussel adhesive protein (MAP) and polycaprolactone (PCL), which provide durable mechanical strength, cell-friendly environments, and a substantial ability to capture diverse bioactive molecules without any surface modifications. In the present work, we applied the blended nanofibrous mats of MAP and PCL for in vivo skin wound healing. The nanofibrous mats showed accelerated regeneration in a rat skin wound-healing model, which might be attributed to a highly compatible environment for keratinocyte cell growth, an ability to capture inherent growth factors, and an efficient exudate absorption capacity. Thus, this work would suggest that adhesive property of scaffold could be a factor of successful application for wound healing. The MAP-blended nanofibers could also be potentially exploited for diverse tissue regeneration applications. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 218-225, 2017.
authors.affiliation: Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, 790-784, Korea.
authors.forename: Bum Jin
authors.initials: BJ
authors.lastname: Kim
authors.affiliation: Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, 790-784, Korea.
authors.forename: Hogyun
authors.initials: H
authors.lastname: Cheong
authors.affiliation: Department of Plastic and Reconstructive Surgery, Daegu Catholic University Medical Center, Daegu, 705-718, Korea.
authors.forename: Eun-Som
authors.initials: ES
authors.lastname: Choi
authors.affiliation: Department of Plastic and Reconstructive Surgery, Daegu Catholic University Medical Center, Daegu, 705-718, Korea.
authors.forename: So-Hee
authors.initials: SH
authors.lastname: Yun
authors.affiliation: Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, 790-784, Korea.
authors.forename: Bong-Hyuk
authors.initials: BH
authors.lastname: Choi
authors.affiliation: Department of Plastic and Reconstructive Surgery, Daegu Catholic University Medical Center, Daegu, 705-718, Korea.
authors.forename: Ki-Soo
authors.initials: KS
authors.lastname: Park
authors.affiliation: Nano Fusion Technology Research Group, Division of Frontier Fibers, Institute for Fiber Engineering, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, Ueda, 386-8567, Japan.
authors.forename: Ick Soo
authors.initials: IS
authors.lastname: Kim
authors.affiliation: Department of Plastic and Reconstructive Surgery, Daegu Catholic University Medical Center, Daegu, 705-718, Korea.
authors.forename: Dae-Hwan
authors.initials: DH
authors.lastname: Park
authors.affiliation: Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, 790-784, Korea.
authors.forename: Hyung Joon
authors.initials: HJ
authors.lastname: Cha
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D015603:Keratinocytes / Q000378:metabolism / Q000473:pathology; D008297:Male; D057139:Nanofibers / Q000737:chemistry / Q000627:therapeutic use; D011091:Polyesters / Q000737:chemistry / Q000494:pharmacology; D011506:Proteins / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000293:injuries / Q000378:metabolism / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D011091:Polyesters; D011506:Proteins; C037403:adhesive protein, mussel; C016240:polycaprolactone
keywords: electrospinning; mussel adhesive protein; nanofibrous mat; skin regeneration; wound healing