title: Sesquiterpenes from the roots of Lindera strychnifolia with inhibitory effects on nitric oxide production in RAW 264.7 cells.
abstract: Seven new sesquiterpenes, linderolides N-T (1-7), along with nine known compounds, were isolated from roots of Lindera strychnifolia (Lauraceae). Their structures were established by extensive spectroscopic analysis. The relative and absolute configurations were determined by NOESY and CD analysis, respectively. Among the isolated compounds, two new compounds, linderolide O (2) and linderolide P (3) inhibited lipopolysaccharide-stimulated nitric oxide production in murine RAW 264.7 macrophage cells, with IC50values of 6.3 and 9.6μM, respectively.
authors.affiliation: College of Pharmacy, Chungbuk National University, Chungdae-ro, Seowon-gu, Cheongju 28644, Republic of Korea.
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
authors.affiliation: College of Pharmacy, Chungbuk National University, Chungdae-ro, Seowon-gu, Cheongju 28644, Republic of Korea.
authors.forename: Yang Hee
authors.initials: YH
authors.lastname: Jo
authors.affiliation: College of Pharmacy, Chungbuk National University, Chungdae-ro, Seowon-gu, Cheongju 28644, Republic of Korea.
authors.forename: Seon Beom
authors.initials: SB
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Chungbuk National University, Chungdae-ro, Seowon-gu, Cheongju 28644, Republic of Korea.
authors.forename: Qinghao
authors.initials: Q
authors.lastname: Jin
authors.affiliation: College of Pharmacy, Chungbuk National University, Chungdae-ro, Seowon-gu, Cheongju 28644, Republic of Korea.
authors.forename: Bang Yeon
authors.initials: BY
authors.lastname: Hwang
authors.affiliation: College of Pharmacy, Chungbuk National University, Chungdae-ro, Seowon-gu, Cheongju 28644, Republic of Korea. Electronic address: mklee@chungbuk.ac.kr.
authors.forename: Mi Kyeong
authors.initials: MK
authors.lastname: Lee
mesh_terms: D000818:Animals; D002460:Cell Line; D020128:Inhibitory Concentration 50; D027443:Lindera / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D018517:Plant Roots / Q000737:chemistry*; D012717:Sesquiterpenes / Q000302:isolation & purification*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D012717:Sesquiterpenes; D009569:Nitric Oxide
keywords: Anti-inflammation; Lauraceae; Lindera strychnifolia; Linderolides N–T; Sesquiterpene