title: The Content of Reticulocyte Hemoglobin and Serum Concentration of the Soluble Transferrin Receptor for Diagnostics of Anemia in Chronically Hemodialyzed Patients.
abstract: BACKGROUND
  Chronic renal disease constitutes a serious worldwide clinical problem. An important issue arising early during the treatment of renal failure is anemia. Patients in the end-stage of renal disease chronically treated with hemodialysis frequently suffer from anemia with iron deficiency.
  
  
  OBJECTIVE
  The aim of the study was to evaluate the usefulness of determining the reticulocyte hemoglobin content and serum concentration of soluble transferrin receptor in the detection of anemia caused by iron deficiency in comparison with the classic markers of iron circulation in serum in chronic dialysis patients with ESRD.
  
  
  METHODS
  66 sets of hematologic results and iron turnover rates were analyzed, sampled from hemodialyzed patients (test group), as well as 34 sets of the same results taken from healthy people (control group). Statistically significant variables were found and a stepwise backward discriminant analysis was performed for them.
  
  
  RESULTS
  The results showed that dialyzed patients have a significantly lower serum concentration of hemoglobin, CHr, HCT, TSAT, Fe and TIBC and significantly higher serum concentration of sTfR, ferritin and C-reactive protein compared to the control group. Based on the results of discriminant analysis, we proposed a scheme for assessing the risk of anemia.
  
  
  CONCLUSIONS
  The concentrations of hemoglobin, soluble transferrin receptor, iron in the serum and C-reactive protein turned out to be the most useful for diagnostic purposes. Moreover, the concentration of soluble transferrin receptor confirmed its high diagnostic value in the detection of iron deficiency-based anemia in patients undergoing dialysis for chronic renal failure at the end-stage compared to conventional iron turnover ratios in the serum.
authors.affiliation: Analytical Laboratory SP ZOZ Team Municipal Hospital, Chorzów, Poland.
authors.forename: Teresa
authors.initials: T
authors.lastname: Kurzawa
authors.affiliation: Statistical Division, Department of Instrumental Analysis, Medical University of Silesia, Sosnowiec, Poland.
authors.forename: Aleksander
authors.initials: A
authors.lastname: Owczarek
authors.affiliation: Department of Medical and Molecular Biology, School of Medicine with the Division of Dentistry, Medical University of Silesia, Zabrze, Poland.
authors.forename: Joanna K
authors.initials: JK
authors.lastname: Strzelczyk
authors.affiliation: Department of Medical and Molecular Biology, School of Medicine with the Division of Dentistry, Medical University of Silesia, Zabrze, Poland.
authors.forename: Karolina
authors.initials: K
authors.lastname: Gołąbek
authors.affiliation: Department of Medical and Molecular Biology, School of Medicine with the Division of Dentistry, Medical University of Silesia, Zabrze, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Wiczkowski
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018798:Anemia, Iron-Deficiency / Q000175:diagnosis* / Q000209:etiology; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016002:Discriminant Analysis; D005293:Ferritins / Q000097:blood; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D007501:Iron / Q000097:blood; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011990:Receptors, Transferrin / Q000097:blood*; D006435:Renal Dialysis / Q000009:adverse effects / Q000379:methods*; D012156:Reticulocytes / Q000378:metabolism*; D012680:Sensitivity and Specificity; D012995:Solubility
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; D011990:Receptors, Transferrin; D002097:C-Reactive Protein; D005293:Ferritins; D007501:Iron
keywords: anemia; hemodialysis patients; reticulocyte hemoglobin content; soluble transferrin receptor