title: Expression of Sialyl Lewis a, Sialyl Lewis x, Lewis y, Gal-3, Gal-7, STMN1 and p16 in cervical dysplasia.
abstract: OBJECTIVE
  Cervical intraepithelial neoplasia (CIN) is commonly divided into three grades. Guidelines increasingly recommend surgery only in CIN 3 lesions. We investigated markers to evaluate differences in CIN 2 and 3 lesions as well as possible predictors for regression/progression in CIN 2 lesions.
  
  
  METHODS
  Biopsies (n = 128) of healthy cervical tissue and CIN 1-3 were stained for Sialyl Lewis a, Sialyl Lewis x, Lewis y, Gal-3, Gal-7, STMN1 and p16.
  
  
  RESULTS
  We observed significant differences between CIN 2 and 3 lesions for Sialyl Lewis a, Sialyl Lewis x, Gal-3, Gal-7, STMN1 and p16. Expression of Sialyl Lewis a was significantly higher in CIN 2 patients who progressed during follow-up.
  
  
  CONCLUSIONS
  Significant differences in marker expression support the differentiation of CIN 2 and 3. Lewis a may help to predict progression/regression in CIN 2 patients.
authors.affiliation: Department for Obstetrics & Gynecology, University Hospital of Munich, Ludwig-Maximilians-University, Marchioninistr. 15, 81377, Munich, Germany.
authors.forename: Theresa M
authors.initials: TM
authors.lastname: Kolben
authors.affiliation: Department for Obstetrics & Gynecology, University Hospital of Munich, Ludwig-Maximilians-University, Marchioninistr. 15, 81377, Munich, Germany.
authors.forename: Franziska
authors.initials: F
authors.lastname: Kraft
authors.affiliation: Department for Obstetrics & Gynecology, University Hospital of Munich, Ludwig-Maximilians-University, Marchioninistr. 15, 81377, Munich, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Kolben
authors.affiliation: Department for Obstetrics & Gynecology, University Hospital of Munich, Ludwig-Maximilians-University, Marchioninistr. 15, 81377, Munich, Germany.
authors.forename: Christine
authors.initials: C
authors.lastname: Goess
authors.affiliation: Department for Obstetrics & Gynecology, University Hospital of Munich, Ludwig-Maximilians-University, Marchioninistr. 15, 81377, Munich, Germany.
authors.forename: Anna
authors.initials: A
authors.lastname: Semmlinger
authors.affiliation: Department for Obstetrics & Gynecology, University Hospital of Munich, Ludwig-Maximilians-University, Marchioninistr. 15, 81377, Munich, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Dannecker
authors.affiliation: Department of Pathology, University Hospital of Munich, Ludwig-Maximilians-University, Marchioninistr. 27, 81377, Munich, Germany.
authors.forename: Elisa
authors.initials: E
authors.lastname: Schmoeckel
authors.affiliation: Department of Pathology, University Hospital of Munich, Ludwig-Maximilians-University, Marchioninistr. 27, 81377, Munich, Germany.
authors.forename: Doris
authors.initials: D
authors.lastname: Mayr
authors.affiliation: Institute for Clinical Radiology, University Hospital of Munich, Ludwig-Maximilians-University, Marchioninistr. 15, 81377, Munich, Germany.
authors.forename: Nora N
authors.initials: NN
authors.lastname: Sommer
authors.affiliation: Department for Obstetrics & Gynecology, University Hospital of Munich, Ludwig-Maximilians-University, Marchioninistr. 15, 81377, Munich, Germany.
authors.forename: Sven
authors.initials: S
authors.lastname: Mahner
authors.affiliation: Department for Obstetrics & Gynecology, University Hospital of Munich, Ludwig-Maximilians-University, Marchioninistr. 15, 81377, Munich, Germany.
authors.forename: Udo
authors.initials: U
authors.lastname: Jeschke
mesh_terms: D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; D016022:Case-Control Studies; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000235:genetics / Q000378:metabolism*; D018450:Disease Progression; D005260:Female; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D060787:Neoplasm Grading; D009844:Oligosaccharides / Q000378:metabolism*; D000080506:Sialyl Lewis X Antigen; D050777:Stathmin / Q000235:genetics / Q000378:metabolism*; D002578:Uterine Cervical Dysplasia / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; D019941:Cyclin-Dependent Kinase Inhibitor p16; D009844:Oligosaccharides; C493995:STMN1 protein, human; D000080506:Sialyl Lewis X Antigen; D050777:Stathmin
keywords: Gal-3; Gal-7; HPV; STMN1; Sialyl Lewis a; Sialyl Lewis x and Lewis y; cervical intraepithelial neoplasia; conization; p16