title: Mitochondrial Antigen Presentation: A Vacuolar Path to Autoimmunity in Parkinson's Disease.
abstract: Mitochondrial antigens can be presented by MHC molecules and initiate adaptive immune responses but the mechanisms of mitochondrial antigen presentation (MitAP) have remained mostly unknown. A recent study proposes a new model whereby MitAP is mediated by a vesicle transport pathway that is suppressed by the Parkinson's disease (PD) associated proteins PTEN-induced putative kinase 1 (PINK1) and Parkin. This discovery brings a new perspective on the link between mitochondrial dysfunction and autoimmunity in PD.
authors.affiliation: German Centre for Neurodegenerative Diseases (DZNE) Tübingen within the Helmholtz Association, Tübingen, Germany; Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
authors.forename: Pascale
authors.initials: P
authors.lastname: Baden
authors.affiliation: German Centre for Neurodegenerative Diseases (DZNE) Tübingen within the Helmholtz Association, Tübingen, Germany; Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany. Electronic address: michela.deleidi@dzne.de.
authors.forename: Michela
authors.initials: M
authors.lastname: Deleidi
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D017951:Antigen Presentation; D001324:Autoantigens / Q000276:immunology / Q000378:metabolism*; D015551:Autoimmunity; D006649:Histocompatibility Antigens / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000276:immunology / Q000378:metabolism*; D018448:Models, Immunological; D010300:Parkinson Disease / Q000276:immunology*; D011494:Protein Kinases / Q000378:metabolism*; D021381:Protein Transport; D022142:Secretory Vesicles / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*; D014617:Vacuoles / Q000378:metabolism; D000099202:PTEN-Induced Putative Kinase
chemical_list: D001324:Autoantigens; D006649:Histocompatibility Antigens; D011494:Protein Kinases; D044767:Ubiquitin-Protein Ligases; D000099202:PTEN-Induced Putative Kinase; C111567:parkin protein