title: The Mechanisms of the Regulation of Immune Response in Patients with Comorbidity of Chronic Obstructive Pulmonary Disease and Asthma.
abstract: Background. Comorbidity of chronic obstructive pulmonary disease (COPD) and asthma (asthma COPD overlap syndrome, ACOS) is a significant problem in pulmonary practice, whose pathogenetic issues are not clarified yet.Objective. To study the features of the regulation of immune response in patients with comorbid COPD and asthma.Methods. We assessed the levels of CD3+, CD4+, CD8+, CD4+/CD8+, CD19+, CD25+, HLA-DR, total IgE, TNF-α, IL-4, IFN-γ, TXB2, and LTB4in patients with comorbid COPD and asthma.Results. The study involved 44 people with COPD, 39 people with asthma, and 12 people with comorbid COPD and asthma. The specific features in comorbid COPD and asthma were lymphocytosis, increased absolute count of T-helper cells, increased cytotoxic T-lymphocytes in relative and absolute count, increased relative and absolute numbers of B-lymphocytes, and high levels of total IgE. The elevated levels of TNF-αand IL-4 and inhibition of IFN-γproduction were detected. The content of LTB4was maximal; TXB2levels were higher than in control group but lower than in COPD and asthma.Conclusion. In comorbid COPD and asthma inflammation increased even during stable period. High levels of eicosanoids, low production of Th1-type cytokines, and active synthesis of opposition IL-4, along with increased IgE, indicate the activation of Th2-type immune response.
authors.affiliation: Institute of Medical Climatology and Rehabilitation Treatment, Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration, 73g Russkaya St., Vladivostok 690105, Russia.
authors.forename: Elena P
authors.initials: EP
authors.lastname: Kalinina
authors.affiliation: Institute of Medical Climatology and Rehabilitation Treatment, Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration, 73g Russkaya St., Vladivostok 690105, Russia.
authors.forename: Yulia K
authors.identifier: 0000-0003-4130-8899
authors.initials: YK
authors.lastname: Denisenko
authors.affiliation: Institute of Medical Climatology and Rehabilitation Treatment, Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration, 73g Russkaya St., Vladivostok 690105, Russia.
authors.forename: Tatyana I
authors.identifier: 0000-0002-1009-9011
authors.initials: TI
authors.lastname: Vitkina
authors.affiliation: Institute of Medical Climatology and Rehabilitation Treatment, Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration, 73g Russkaya St., Vladivostok 690105, Russia.
authors.forename: Elena G
authors.initials: EG
authors.lastname: Lobanova
authors.affiliation: Institute of Medical Climatology and Rehabilitation Treatment, Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration, 73g Russkaya St., Vladivostok 690105, Russia.
authors.forename: Tatyana P
authors.initials: TP
authors.lastname: Novgorodtseva
authors.affiliation: Institute of Medical Climatology and Rehabilitation Treatment, Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration, 73g Russkaya St., Vladivostok 690105, Russia.
authors.forename: Marina V
authors.initials: MV
authors.lastname: Antonyuk
authors.affiliation: Institute of Medical Climatology and Rehabilitation Treatment, Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration, 73g Russkaya St., Vladivostok 690105, Russia.
authors.forename: Tatyana A
authors.initials: TA
authors.lastname: Gvozdenko
authors.affiliation: Institute of Medical Climatology and Rehabilitation Treatment, Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration, 73g Russkaya St., Vladivostok 690105, Russia.
authors.forename: Vera V
authors.initials: VV
authors.lastname: Knyshova
authors.affiliation: Institute of Medical Climatology and Rehabilitation Treatment, Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration, 73g Russkaya St., Vladivostok 690105, Russia.
authors.forename: Anna V
authors.identifier: 0000-0003-1214-5752
authors.initials: AV
authors.lastname: Nazarenko