title: Polyphosphoesters: New Trends in Synthesis and Drug Delivery Applications.
abstract: Polymers with repeating phosphoester linkages in the backbone are biodegradable materials that emerge as a promising class of novel biomaterials, especially in the field of drug delivery systems. In contrast to aliphatic polyesters, the pentavalency of the phosphorus atom offers a large diversity of structures and as a consequence a wide range of properties for these materials. In this paper, it is focused on the synthesis of well-defined polyphosphoesters (PPEs) by organocatalyzed ring-opening polymerization, improving the functionalities by combination with click reactions, degradation of functional PPEs and their cytotoxicity, and inputs for applications in drug delivery.
authors.affiliation: Center for Education and Research on Macromolecules (CERM), University of Liège (ULg), CESAM-RU, Sart Tilman, Building B6a, Liège, B-4000, Belgium.
authors.forename: Zeynep Ergul
authors.initials: ZE
authors.lastname: Yilmaz
authors.affiliation: Center for Education and Research on Macromolecules (CERM), University of Liège (ULg), CESAM-RU, Sart Tilman, Building B6a, Liège, B-4000, Belgium.
authors.forename: Christine
authors.initials: C
authors.lastname: Jérôme
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D001419:Bacteria / Q000187:drug effects; D001672:Biocompatible Materials / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D016503:Drug Delivery Systems / Q000379:methods; D004952:Esters / Q000138:chemical synthesis*; D006801:Humans; D051379:Mice; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D004952:Esters; D011108:Polymers
keywords: click reactions; drug delivery; hydrolytic degradation; organocatalyzed ROP; polyphosphoesters