title: Choroidal Structural Changes in Myopic Choroidal Neovascularization After Treatment With Antivascular Endothelial Growth Factor Over 1 Year.
abstract: OBJECTIVE
  To evaluate choroidal structural changes in eyes with myopic choroidal neovascularization (mCNV) treated with anti-VEGF over 12 months.
  
  
  METHODS
  We prospectively evaluated subfoveal choroidal thickness (SFCT) and choroidal vascularity index (CVI) using spectral-domain optical coherence tomography (SD-OCT) at baseline, 6, and 12 months in both eyes in patients presenting with unilateral mCNV. Choroidal vascularity index was defined as the ratio of luminal area to total choroidal area after SD-OCT images were binarized digitally.
  
  
  RESULTS
  We included 20 patients (20 eyes with mCNV and 20 fellow eyes without mCNV) with mean age of 60.35 ± 10.85 years. At baseline, mean SFCT and CVI was similar between eyes with mCNV and fellow eyes (69.20 ± 63.04 μm vs. 67.10 ± 65.74 μm, P = 0.713 for SFCT and 59.44 ± 3.92% vs. 59.03 ±. 5.58%, P = 0.958 for CVI). Subfoveal choroidal thickness decreased significantly in the mCNV eyes to 54.75 ± 45.43 μm (P = 0.017) at 12 months after anti-VEGF therapy, whereas SFCT in the contralateral eyes did not change significantly. There was no significant change in CVI in mCNV eyes or contralateral eyes from baseline to 12 months. Thinning of SFCT did not influence final BCVA.
  
  
  CONCLUSIONS
  Thinning of subfoveal choroid without alteration in CVI was observed in eyes with mCNV treated with anti-VEGF therapy over 12 months. This finding may be explained by mechanical stretching in response to globe expansion.
authors.affiliation: Singapore National Eye Centre, Singapore.
authors.forename: Wei Yan
authors.initials: WY
authors.lastname: Ng
authors.affiliation: Singapore National Eye Centre, Singapore.
authors.forename: Daniel Shu Wei
authors.initials: DS
authors.lastname: Ting
authors.affiliation: Singapore Eye Research Institute, Singapore 3National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore.
authors.forename: Rupesh
authors.initials: R
authors.lastname: Agrawal
authors.affiliation: National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore.
authors.forename: Neha
authors.initials: N
authors.lastname: Khandelwal
authors.affiliation: Singapore Eye Research Institute, Singapore 4Ophthalmology Academic Clinical Program, Duke-NUS Medical School, Singapore.
authors.forename: Hla Myint
authors.initials: HM
authors.lastname: Htoon
authors.affiliation: Singapore National Eye Centre, Singapore 4Ophthalmology Academic Clinical Program, Duke-NUS Medical School, Singapore.
authors.forename: Shu Yen
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Singapore National Eye Centre, Singapore 2Singapore Eye Research Institute, Singapore 4Ophthalmology Academic Clinical Program, Duke-NUS Medical School, Singapore 5Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Tien Yin
authors.initials: TY
authors.lastname: Wong
authors.affiliation: Singapore National Eye Centre, Singapore 2Singapore Eye Research Institute, Singapore 4Ophthalmology Academic Clinical Program, Duke-NUS Medical School, Singapore 5Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Gemmy Chui Ming
authors.initials: GC
authors.lastname: Cheung