title: RIFM fragrance ingredient safety assessment, 2-ethyl-1-butanol, CAS Registry Number 97-95-0.
abstract: The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog 2-ethylhexanol (CAS # 104-76-7) show that this material is not genotoxic. Data from the suitable read across analog isopropyl alcohol (CAS # 67-63-0) show that this material does not have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (1.4 mg/day). The repeated dose toxicity endpoint was completed using 2-ethylhexanol (CAS # 104-76-7) and 1-heptanol, 2-propyl (CAS # 10042-59-8) as suitable read across analogs, which provided a MOE > 100. The developmental and reproductive toxicity endpoint was completed using 2-ethyl-hexanol (CAS # 104-76-7) and isobutyl alcohol (CAS # 78-83-1) as suitable read across analogs, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA. Electronic address: AApi@rifm.org.
authors.forename: A M
authors.initials: AM
authors.lastname: Api
authors.affiliation: Columbia University Medical Center, Department of Dermatology, 161 Fort Washington Ave., New York, NY, 10032, USA.
authors.forename: D
authors.initials: D
authors.lastname: Belsito
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.
authors.forename: S
authors.initials: S
authors.lastname: Bhatia
authors.affiliation: Malmo University Hospital, Department of Occupational & Environmental Dermatology, Sodra Forstadsgatan 101, Entrance 47, Malmo, SE-20502, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Bruze
authors.affiliation: Humphrey School of Public Affairs, University of Minnesota, 301 19th Avenue South, Minneapolis, MN, 55455, USA.
authors.forename: P
authors.initials: P
authors.lastname: Calow
authors.affiliation: University of Sao Paulo, School of Veterinary Medicine and Animal Science, Department of Pathology, Av. Prof. Dr. Orlando Marques de Paiva, 87, Sao Paulo, CEP 05508-900, Brazil.
authors.forename: M L
authors.initials: ML
authors.lastname: Dagli
authors.affiliation: University of Wuerzburg, Department of Toxicology, Versbacher Str. 9, 97078, Würzburg, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Dekant
authors.affiliation: Oregon Health Science University, 3181 SW Sam Jackson Park Rd., Portland, OR, 97239, USA.
authors.forename: A D
authors.initials: AD
authors.lastname: Fryer
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.
authors.forename: L
authors.initials: L
authors.lastname: Kromidas
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.
authors.forename: S
authors.initials: S
authors.lastname: La Cava
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.
authors.forename: J F
authors.initials: JF
authors.lastname: Lalko
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.
authors.forename: A
authors.initials: A
authors.lastname: Lapczynski
authors.affiliation: Vanderbilt University School of Medicine, Department of Biochemistry, Center in Molecular Toxicology, 638 Robinson Research Building, 2200 Pierce Avenue, Nashville, TN, 37232-0146, USA.
authors.forename: D C
authors.initials: DC
authors.lastname: Liebler
authors.affiliation: Department of Dermatology, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Miyachi
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.
authors.forename: V T
authors.initials: VT
authors.lastname: Politano
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.
authors.forename: G
authors.initials: G
authors.lastname: Ritacco
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.
authors.forename: D
authors.initials: D
authors.lastname: Salvito
authors.affiliation: The University of Tennessee, College of Veterinary Medicine, Department of Comparative Medicine, 2407 River Dr., Knoxville, TN, 37996-4500, USA.
authors.forename: T W
authors.initials: TW
authors.lastname: Schultz
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.
authors.forename: J
authors.initials: J
authors.lastname: Shen
authors.affiliation: Department of Pharmacology, University of Arizona, College of Medicine, 1501 North Campbell Avenue, P.O. Box 245050, Tucson, AZ, 85724-5050, USA.
authors.forename: I G
authors.initials: IG
authors.lastname: Sipes
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.
authors.forename: B
authors.initials: B
authors.lastname: Wall
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.
authors.forename: D K
authors.initials: DK
authors.lastname: Wilcox
mesh_terms: D000818:Animals; D003257:Consumer Product Safety; D004249:DNA Damage / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D023381:Endpoint Determination; D000441:Hexanols / Q000737:chemistry / Q000633:toxicity*; D019055:No-Observed-Adverse-Effect Level; D010476:Perfume / Q000737:chemistry / Q000633:toxicity*; D051381:Rats; D018570:Risk Assessment; D018675:Toxicity Tests / Q000379:methods*
chemical_list: D000441:Hexanols; D010476:Perfume; C553992:2-ethyl-1-butanol
keywords: Developmental and reproductive; Environmental safety; Genotoxicity; Local respiratory toxicity; Phototoxicity/photoallergenicity; Repeated dose; Skin sensitization; Toxicity