title: [Histopathologic comparison of dexmedetomidine's and thiopental's cerebral protective effects on focal cerebral ischemia in rats].
abstract: This study was designed to investigate whether dexmedetomidine and thiopental have cerebral protective effects after focal cerebral ischemia in rats. Thirty male Sprague Dawley rats were randomly assigned to three groups: control group (Group C, n=10), dexmedetomidine group (Group D, n=10), thiopental group (Group T, n=10). After all rats were anesthetized, they were intubated, then mechanically ventilated. A catheter was inserted into the right femoral artery for continuous mean arterial pressure, physiological parameters and blood sampling at baseline, 5min after occlusion and 20min after reperfusion. A catheter was inserted into the left femoral vein for intravenous (IV) medication administration. Right common carotid artery of each rat was isolated and clamped for 45min. At the end of the duration common carotid artery were unclamped and the brain reperfusion was achieved for 90min. Dexmedetomidine was administered for Group D IV infusion, and Group T received thiopental IV. According to histopathologic scores cerebral ischemia was documented in all rats in Group C, but no ischemia was found in three rats in Group T and in four rats in Group D. Grade 3 cerebral ischemia was documented in three rats in Group C, and in only one rat in both groups T and D. For histopathologic grades the difference between Group T and Group D was not significant (p>0.05). But the differences between Group C and Group T (p<0.05) and Group C and Group D (p<0.01) were statically significant. In conclusion, we demonstrated that dexmedetomidine and thiopental have experimental histopathologic cerebral protective effects on experimental focal cerebral ischemia in rats.
authors.affiliation: Ordu University, Training and Research Hospital, Clinic of Anesthesiology and Reanimation, Ordu, Turquia. Electronic address: canakciebru@gmail.com.
authors.forename: Ebru
authors.initials: E
authors.lastname: Çanakçı
authors.affiliation: Erzurum Training and Research Hospital, Department of Pathology, Erzurum, Turquia.
authors.forename: Sevilay Akalp
authors.initials: SA
authors.lastname: Özmen
authors.affiliation: Ordu State Hospital, Clinic of Anesthesiology and Reanimation, Ordu, Turkey.
authors.forename: Mustafa Ferhat
authors.initials: MF
authors.lastname: Çolak
authors.affiliation: Atatük University, Faculty of Medicine, Research Hospital, Clinic of Anesthesiology and Reanimation, Erzurum, Turquia.
authors.forename: Hüsnü
authors.initials: H
authors.lastname: Kürşad
keywords: Brain ischemia; Dexmedetomidina; Dexmedetomidine; Isquemia encefálica; Neuroprotection; Neuroproteção; Thiopental; Tiopental