title: Transforming LiTMP Lithiation of Challenging Diazines through Gallium Alkyl Trans-Metal-Trapping.
abstract: This study establishes a new trans-metal-trapping (TMT) procedure based on a mixture of LiTMP (the base) and tris(trimethylsilylmethyl)gallium [Ga(CH2SiMe3)3, GaR3] (the trap) that, operating in a tandem manner, is effective for the regioselective deprotonation of sensitive diazines in hydrocarbon solution, as illustrated through reactions of pyrazine, pyridazine, and pyrimidine, as well as through the N-S heterocycle benzothiazole. The metallo-activated complexes of all of these compounds were isolated and structurally defined.
authors.affiliation: WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, G1 1XL, UK.
authors.forename: Marina
authors.initials: M
authors.lastname: Uzelac
authors.affiliation: WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, G1 1XL, UK.
authors.forename: Alan R
authors.identifier: 0000-0003-3652-6015
authors.initials: AR
authors.lastname: Kennedy
authors.affiliation: WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, G1 1XL, UK. eva.hevia@strath.ac.uk.
authors.forename: Eva
authors.identifier: 0000-0002-3998-7506
authors.initials: E
authors.lastname: Hevia
authors.affiliation: WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, G1 1XL, UK. r.e.mulvey@strath.ac.uk.
authors.forename: Robert E
authors.identifier: 0000-0002-1015-2564
authors.initials: RE
authors.lastname: Mulvey
keywords: diazines; gallium; heterocyclic chemistry; lithiation; structure elucidation