title: Characteristics of Cerebral White Matter Lesions on MRI in Juvenile Patients with Migraine.
abstract: OBJECTIVE
  Cerebral white matter lesions (WMLs) have been frequently observed on MRI in patients with migraine. We investigated characteristics of WMLs in migraine and tried to determine the relationship between its causal mechanism and arteriosclerosis.
  
  
  METHODS
  A head MRI was performed in juvenile migraine patients. The distributions of deep and periventricular WMLs were separately studied in the anterior and posterior circulation. Grading was conducted according to the Fazekas classification. Arteriosclerotic risk factors were identified, and their effects on WMLs were investigated.
  
  
  RESULTS
  WMLs were observed in 85 (40.5%) of 210 patients in our hospital. This is significantly higher than the 10 (19.2%) of 63 patients in the control group (p < 0.01). WMLs were significantly observed on the anterior territory of the deep white matter (p < 0.01) and the posterior territory of the periventricular white matter (p < 0.05). Multivariable analysis revealed that the occurrence of WMLs was not related to arteriosclerotic risk factors, while migraine (p < 0.01) and aging (p < 0.05) were significant risk factors.
  
  
  CONCLUSIONS
  While migraine was a risk factor of WMLs, its relationship with arteriosclerotic factors was weak. Accordingly, a mechanism other than arteriosclerosis may be involved.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yasuda
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kodera
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Iijima
authors.forename: Atsushi
authors.initials: A
authors.lastname: Mizuma
authors.forename: Kentaro
authors.initials: K
authors.lastname: Tokuoka
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Okuma
authors.forename: Shunya
authors.initials: S
authors.lastname: Takizawa
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Kitagawa
authors.affiliation: Department of Neurology, Tokai University Hachioji Hospital, 1838 Ishikawamachi, Hachioji, Tokyo 192-0032, Japan. snogawa@tokai-u.jp.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Nogawa
mesh_terms: D000328:Adult; D000375:Aging; D001161:Arteriosclerosis / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008881:Migraine Disorders / Q000000981:diagnostic imaging*; D012307:Risk Factors; D066127:White Matter / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology; D055815:Young Adult