title: Serological prevalence of celiac disease in Brazilian population of multiple sclerosis, neuromyelitis optica and myelitis.
abstract: OBJECTIVE
  Comorbidity of celiac disease with demyelinating diseases of the central nervous system has been reported since the 1960s. The objective of this study was to determine the serological prevalence of celiac disease in the largest series of patients diagnosed with multiple sclerosis, neuromyelitis optica, or myelitis.
  
  
  METHODS
  A prevalence study was conducted with patients evaluated at Sarah Network of Rehabilitation Hospitals between March 2012 and September 2013. They were previously diagnosed with multiple sclerosis, neuromyelitis optica, or idiopathic myelitis. The serum levels of antibodies against tissue transglutaminase and endomysium were assessed.
  
  
  RESULTS
  Of the 379 patients evaluated, 249 (65.70%) were diagnosed with multiple sclerosis, 37 (9.56%) with neuromyelitis optica, and 96 (24.54%) with idiopathic myelitis. Two patients (0.53%), one with multiple sclerosis and other with myelitis, tested positive for both antibodies.
  
  
  CONCLUSIONS
  Our study do not confirm the relationship between celiac serological antibodies with multiple sclerosis, neuromyelitis optica and inflammatory myelitis of an unknown etiology.
authors.affiliation: Medical neurologist, Department of Neurology, Sarah Network of Rehabilitation Hospitals, SMHS Quadra 501 Conj. A, Brasilia, DF 70.330-150 Brazil. Electronic address: 12918@sarah.br.
authors.forename: Pérola
authors.initials: P
authors.lastname: de Oliveira
authors.affiliation: Medical geneticist, Department of Genetics, Sarah Network of Rehabilitation Hospitals, Brasilia, Brazil. Electronic address: danielcarvalho@sarah.br.
authors.forename: Daniel Rocha
authors.initials: DR
authors.lastname: de Carvalho
authors.affiliation: Medical neurologist, Department of Neurology, Sarah Network of Rehabilitation Hospitals, Salvador, Brazil. Electronic address: 205364@sarah.br.
authors.forename: Ivar Viana
authors.initials: IV
authors.lastname: Brandi
authors.affiliation: Research Center on Chronic and Immunogenetic Diseases of the Faculty of Medicine, University of Brasilia, Brasilia, Brazil. Electronic address: pratesir@unb.br.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Pratesi
mesh_terms: D000293:Adolescent; D000328:Adult; D001938:Brazil / Q000453:epidemiology; D002446:Celiac Disease / Q000097:blood / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000453:epidemiology*; D009187:Myelitis / Q000097:blood / Q000453:epidemiology*; D009471:Neuromyelitis Optica / Q000097:blood / Q000453:epidemiology*; D015995:Prevalence; D012189:Retrospective Studies; D055815:Young Adult
keywords: Celiac disease; Epidemiology; Multiple sclerosis; Myelitis; Neuromyelitis optica