title: Expression of Wnt11 and Rock2 in esophageal squamous cell carcinoma by activation of the WNT/PCP pathway and its clinical significance.
abstract: The purpose of this study was to investigate the relation between expression of Wnt11, Rho-associated protein kinase 2 (Rock2), and its clinical characteristics in esophageal squamous cell carcinoma (ESCC). Expression of Wnt11 and Rock2 protein was examined by using immunohistochemistry that contained 260 paraffin-embedded specimens of ESCC and its adjacent normal tissues; expression of Wnt11 and Rock2 protein was verified by Western-blotting that contained 20 specimens of ESCC and its adjacent normal tissues. The positive rates of Wnt11 protein in normal esophageal epithelium tissue was 29.8% and in esophageal carcinomas tissue was 31.9%; there was no significant difference between the two groups(P>0.05); The positive rates of Rock2 protein in normal esophageal epithelium tissue was 12.3% and in esophageal carcinomas tissues was 56.5%, there was a significant difference between the two groups (p<0.05). The expression of Rock2 protein was significantly related with the invasion of vascular and there was no significantly difference between the expression of Rock2 protein and ESCC patients' tumor location, differentiation, T stage, and lymph node metastases. The abnormal expression of Rock2 protein may promote tumor cell invasion.
authors.affiliation: Department of Pathology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China. Electronic address: wangxuefen2010@126.com.
authors.forename: Xuefen
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Pathology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Liu
authors.affiliation: Hypertension Center of the People's Hospital of Xinjiang Uygur Autonomous Region, Hypertension Institute of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang 83000, China.
authors.forename: Keming
authors.initials: K
authors.lastname: Zhou
authors.affiliation: Department of Pathology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Bowei
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Pathology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Pathology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Feiyan
authors.initials: F
authors.lastname: Deng
authors.affiliation: Department of Pathology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Qiaoxin
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Pathology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China. Electronic address: mayuqing-patho@hotmail.com.
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Ma
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009367:Neoplasm Staging; D051153:Wnt Proteins / Q000378:metabolism*; D060449:Wnt Signaling Pathway / Q000502:physiology*; D054460:rho-Associated Kinases / Q000378:metabolism*
chemical_list: D051153:Wnt Proteins; C540523:Wnt11 protein, human; C515852:ROCK2 protein, human; D054460:rho-Associated Kinases
keywords: Esophageal squamous cell carcinoma; Invasion; Rock2; WNT/PCP pathway; Wnt11