title: Serous degeneration of bone marrow mimics spinal tumor.
abstract: To present a rare case of serous degeneration of bone marrow which resembles primary spinal tumor or bony metastasis to spine. Serous degeneration of bone marrow or gelatinous marrow transformation is a rare disease characterized by focal marrow hypoplasia, fat atrophy, and accumulation of extracellular mucopolysaccharides abundant in hyaluronic acid. Few literature was reviewed and few clinical case was presented.
  
  
  
  Two cases of serous marrow transformation were reported.
  
  
  
  In the first case, a 29-year-old man suffered from severe left buttock pain. Bone metastasis was impressed in radiology examinations. Percutaneous endoscopic lumbar discectomy was performed along with bone biopsy. In the second case, a 49-year-old man presented lower back pain with radiation to bilateral lower legs. Magnetic resonance imaging revealed a water-like signal lesion in sacrum. Serous marrow transformation was confirmed pathologically in both cases.
  
  
  
  To the best of our knowledge, a case of serous degeneration of bone marrow resembling malignancy has not been reported in the literature. In this report, two cases demonstrate serous transformation of bone marrow mimics spinal tumor.
authors.affiliation: School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
authors.forename: Chih-Wei
authors.initials: CW
authors.lastname: Sung
authors.affiliation: Department of Medical Imaging, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.|Translational Imaging Research Center, College of Medicine, Taipei Medical University, Taipei, Taiwan.
authors.forename: Kevin Li-Chun
authors.initials: KL
authors.lastname: Hsieh
authors.affiliation: Division of Oral Pathology, Department of Dentistry, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.|School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
authors.forename: Yun-Ho
authors.initials: YH
authors.lastname: Lin
authors.affiliation: Department of Orthopaedics Surgery, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.
authors.forename: Chun-Yi
authors.initials: CY
authors.lastname: Lin
authors.affiliation: Department of Orthopaedics Surgery, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.|Department of Orthopaedics Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
authors.forename: Chian-Her
authors.initials: CH
authors.lastname: Lee
authors.affiliation: Department of Orthopaedics Surgery, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan.|Department of Orthopaedics Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
authors.forename: Yang-Hwei
authors.initials: YH
authors.lastname: Tsuang
authors.affiliation: Department of Orthopaedics Surgery, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan. benkuo5@tmu.edu.tw.|Department of Orthopaedics Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. benkuo5@tmu.edu.tw.
authors.forename: Yi-Jie
authors.initials: YJ
authors.lastname: Kuo
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000000981:diagnostic imaging; D001855:Bone Marrow Diseases / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D003937:Diagnosis, Differential; D017587:Diskectomy, Percutaneous; D005780:Gelatin; D006025:Glycosaminoglycans; D006801:Humans; D006820:Hyaluronic Acid; D007405:Intervertebral Disc Displacement / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D012447:Sacrum / Q000000981:diagnostic imaging* / Q000473:pathology; D013125:Spinal Neoplasms / Q000000981:diagnostic imaging*
chemical_list: D006025:Glycosaminoglycans; D005780:Gelatin; D006820:Hyaluronic Acid
keywords: Gelatinous marrow transformation; Magnetic resonance imaging; Serous atrophy; Serous degeneration