title: Sodium alginate stabilized silver nanoparticles-silica nanohybrid and their antibacterial characteristics.
abstract: Due to the problem of resistance of many infectious agents to the usual treatments, this study addresses the ways of obtaining and using new sodium alginate stabilized-silver/mesoporous silica (Na-Alg-s-AgNPs@SiO2) nanohybrid as antimicrobial agents. Capping AgNPs with a shell of mesoporous SiO2is a system to build the increase biocompatibility of AgNPs. In this work, we report a simple and green way to deal with setting up a uniform sodium alginate-stabilized silver nanoparticles embedded mesoporous silica (Na-Alg-s-AgNPs@SiO2nanohybrid). The synthesized nanocomposite was characterized using transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectra, and ultraviolet-visible (UV-vis) absorption spectra, which exhibited that AgNPs with average of size of ∼7nm were consistently and compactly deposited in the nanocomposite. The nanohybrid demonstrated excellent antibacterial activity against both Gram negative (-ve) and Gram positive (+ve) bacteria. Thus, the developed Na-Alg-s-AgNPs@SiO2nanohybrid has a potential to be used for various antibacterial applications in biotechnology and biomedical fields.
authors.affiliation: Department of Applied Chemistry, University of Johannesburg, P.O. Box 17011, Doornfontien 2028, Johannesburg, South Africa; Centre for Nanomaterials Science Research, University of Johannesburg, South Africa. Electronic address: sadanand.au@gmail.com.
authors.forename: Sadanand
authors.initials: S
authors.lastname: Pandey
authors.affiliation: Department of Applied Chemistry, University of Johannesburg, P.O. Box 17011, Doornfontien 2028, Johannesburg, South Africa; Centre for Nanomaterials Science Research, University of Johannesburg, South Africa.
authors.forename: James
authors.initials: J
authors.lastname: Ramontja
mesh_terms: D000464:Alginates / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D020723:Glucuronic Acid / Q000737:chemistry / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000254:growth & development*; D006094:Gram-Positive Bacteria / Q000254:growth & development*; D006603:Hexuronic Acids / Q000737:chemistry / Q000494:pharmacology; D053768:Metal Nanoparticles / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry / Q000494:pharmacology; D012834:Silver / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000464:Alginates; D000900:Anti-Bacterial Agents; D006603:Hexuronic Acids; D012834:Silver; D012822:Silicon Dioxide; D020723:Glucuronic Acid
keywords: Antimicrobial activity; Bacteria; Biopolymer; Dispersity; Nanohybrid; Silver nanoparticles