title: UV-Induced Adenine Radicals Induced in DNA A-Tracts: Spectral and Dynamical Characterization.
abstract: Adenyl radicals generated in DNA single and double strands, (dA)20and (dA)20·(dT)20, by one- and two-photon ionization by 266 nm laser pulses decay at 600 nm with half-times of 1.0 ± 0.1 and 4 ± 1 ms, respectively. Though ionization initially forms the cation radical, the radicals detected for (dA)20are quantitatively identified as N6-deprotonated adenyl radicals by their absorption spectrum, which is computed quantum mechanically employing TD-DFT. Theoretical calculations show that deprotonation of the cation radical induces only weak spectral changes, in line with the spectra of the adenyl radical cation and the deprotonated radical trapped in low temperature glasses.
authors.affiliation: LIDYL, CEA, CNRS, Université Paris-Saclay , F-91191 Gif-sur-Yvette, France.
authors.forename: Akos
authors.initials: A
authors.lastname: Banyasz
authors.affiliation: LIDYL, CEA, CNRS, Université Paris-Saclay , F-91191 Gif-sur-Yvette, France.
authors.forename: Tiia-Maaria
authors.initials: TM
authors.lastname: Ketola
authors.affiliation: LIDYL, CEA, CNRS, Université Paris-Saclay , F-91191 Gif-sur-Yvette, France.
authors.forename: Aurora
authors.initials: A
authors.lastname: Muñoz-Losa
authors.affiliation: Department of Chemistry, Oakland University , Rochester, Michigan 48309, United States.
authors.forename: Sunny
authors.initials: S
authors.lastname: Rishi
authors.affiliation: Department of Chemistry, Oakland University , Rochester, Michigan 48309, United States.
authors.forename: Amitava
authors.initials: A
authors.lastname: Adhikary
authors.affiliation: Department of Chemistry, Oakland University , Rochester, Michigan 48309, United States.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Sevilla
authors.affiliation: Istituto Biostrutture e Bioimmagini-Consiglio Nazionale delle Ricerche, Via Mezzocannone 16, I-80134 Napoli, Italy.
authors.forename: Lara
authors.initials: L
authors.lastname: Martinez-Fernandez
authors.affiliation: Istituto Biostrutture e Bioimmagini-Consiglio Nazionale delle Ricerche, Via Mezzocannone 16, I-80134 Napoli, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Improta
authors.affiliation: LIDYL, CEA, CNRS, Université Paris-Saclay , F-91191 Gif-sur-Yvette, France.
authors.forename: Dimitra
authors.initials: D
authors.lastname: Markovitsi
mesh_terms: D000225:Adenine / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals / Q000737:chemistry*; D017665:Hydroxyl Radical / Q000737:chemistry; D017785:Photons; D011789:Quantum Theory; D013053:Spectrophotometry; D014466:Ultraviolet Rays
chemical_list: D005609:Free Radicals; D017665:Hydroxyl Radical; D004247:DNA; D000225:Adenine