title: 8-isoprostane as Oxidative Stress Marker in Coal Mine Workers.
abstract: This study was to investigate whether working in conditions of elevated concentrations of mine gases (CO2, CO, CH4, DMS) and dust may result in oxidative stress. Coal miners (n=94) from the Velenje Coal mine who were arranged into control group and three groups according to a number of consecutive working days. 8-isoprostane as a biological marker of oxidative stress was measured in exhaled breath condensate (EBC). Miners who worked for three consecutive days had higher 8-isoprostane values in EBC compared to the control group. Gas/dust concentrations and exposure time of a single/two day shift seem too low to trigger immediate oxidative stress.
authors.affiliation: National Institute of Public Health, Trubarjeva 2, 1000 Ljubljana, Slovenia.
authors.forename: Zlatko
authors.initials: Z
authors.lastname: Zimet
authors.affiliation: Department of Public Health, Faculty of Medicine, University of Ljubljana, Zaloška 4, 1000 Ljubljana Slovenia.
authors.forename: Marjan
authors.initials: M
authors.lastname: Bilban
authors.affiliation: University Clinic of Pulmonary and Allergic Diseases Golnik, Golnik 36, 4204 Golnik, Slovenia.
authors.forename: Mateja
authors.initials: M
authors.lastname: Marc Malovrh
authors.affiliation: University Clinic of Pulmonary and Allergic Diseases Golnik, Golnik 36, 4204 Golnik, Slovenia.
authors.forename: Peter
authors.initials: P
authors.lastname: Korošec
authors.affiliation: Faculty of Health Sciences, University of Ljubljana, Zdravstvena pot 5, 1000 Ljubljana, Slovenia.
authors.forename: Borut
authors.initials: B
authors.lastname: Poljšak
authors.affiliation: University Medical Centre Ljubljana, Institute of Clinical Chemistry and Biochemistry, Njegoseva 4, 1000 Ljubljana, Slovenia.
authors.forename: Joško
authors.initials: J
authors.lastname: Osredkar
authors.affiliation: University Clinic of Pulmonary and Allergic Diseases Golnik, Golnik 36, 4204 Golnik, Slovenia.
authors.forename: Mira
authors.initials: M
authors.lastname: Šilar
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis; D001944:Breath Tests; D003031:Coal / Q000009:adverse effects; D003032:Coal Mining; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000032:analysis; D004391:Dust / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D000067572:Miners / Q000706:statistics & numerical data; D016273:Occupational Exposure / Q000032:analysis; D018384:Oxidative Stress; D000078329:Workforce
chemical_list: D015415:Biomarkers; D003031:Coal; D004391:Dust; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost