title: Synthesis of Pyrido-annelated Diazepines, Oxazepines and Thiazepines.
abstract: The immense amount of research on benzodiazepines resulted in the synthesis of heterocycle-fused diazepine derivatives with potential pharmacological activity. Pyridoazepines are recognized to be active in the central nervous system and have a comparable activity to the well-known benzodiazepines. This makes the synthesis and the study of pyridodiazepines an important research topic. This review comprises of the synthesis and activity of pyridodiazepines, pyridooxazepines and pyridothiazepines. Although these structures have a great similarity with benzodiazepines, much less work has been published on their synthesis or derivatization. Therefore, there is a need to further develop these classes of underexplored scaffolds, in search for new chemistry, new methodology and hence new biological features.
authors.forename: Koen
authors.initials: K
authors.lastname: Muylaert
authors.forename: Martyna
authors.initials: M
authors.lastname: Jatczak
authors.forename: Sven
authors.initials: S
authors.lastname: Mangelinckx
authors.affiliation: Department of Sustainable Organic Chemistry and Technology, Campus Coupure, Ghent University, Coupure Links 653, 9000 Ghent, Belgium.
authors.forename: Christian V
authors.initials: CV
authors.lastname: Stevens
mesh_terms: D002490:Central Nervous System / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D006801:Humans; D010077:Oxazepines / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D011725:Pyridines / Q000737:chemistry*; D013841:Thiazepines / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D010077:Oxazepines; D011725:Pyridines; D013841:Thiazepines; C023666:pyridine