title: Black-blood native T1mapping: Blood signal suppression for reduced partial voluming in the myocardium.
abstract: To study the feasibility of black-blood contrast in native T1mapping for reduction of partial voluming at the blood-myocardium interface.
  
  
  
  A saturation pulse prepared heart-rate-independent inversion recovery (SAPPHIRE) T1mapping sequence was combined with motion-sensitized driven-equilibrium (MSDE) blood suppression for black-blood T1mapping at 3 Tesla. Phantom scans were performed to assess the T1time accuracy. In vivo black-blood and conventional SAPPHIRE T1mapping was performed in eight healthy subjects and analyzed for T1times, precision, and inter- and intraobserver variability. Furthermore, manually drawn regions of interest (ROIs) in all T1maps were dilated and eroded to analyze the dependence of septal T1times on the ROI thickness.
  
  
  
  Phantom results and in vivo myocardial T1times show comparable accuracy with black-blood compared to conventional SAPPHIRE (in vivo: black-blood: 1562 ± 56 ms vs. conventional: 1583 ± 58 ms, P = 0.20); Using black-blood SAPPHIRE precision was significantly lower (standard deviation: 133.9 ± 24.6 ms vs. 63.1 ± 6.4 ms, P < .0001), and blood T1time measurement was not possible. Significantly increased interobserver interclass correlation coefficient (ICC) (0.996 vs. 0.967, P = 0.011) and similar intraobserver ICC (0.979 vs. 0.939, P = 0.11) was obtained with the black-blood sequence. Conventional SAPPHIRE showed strong dependence on the ROI thickness (R2= 0.99). No such trend was observed using the black-blood approach (R2= 0.29).
  
  
  
  Black-blood SAPPHIRE successfully eliminates partial voluming at the blood pool in native myocardial T1mapping while providing accurate T1times, albeit at a reduced precision. Magn Reson Med 78:484-493, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
authors.affiliation: Computer Assisted Clinical Medicine, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.|Electrical and Computer Engineering, University of Minnesota, Minneapolis, Minnesota, United States.|Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, United States.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Weingärtner
authors.affiliation: Computer Assisted Clinical Medicine, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.|DZHK (German Centre for Cardiovascular Research) partner site Mannheim, Germany.
authors.forename: Nadja M
authors.initials: NM
authors.lastname: Meßner
authors.affiliation: Computer Assisted Clinical Medicine, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.
authors.forename: Frank G
authors.initials: FG
authors.lastname: Zöllner
authors.affiliation: Electrical and Computer Engineering, University of Minnesota, Minneapolis, Minnesota, United States.|Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, United States.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Akçakaya
authors.affiliation: Computer Assisted Clinical Medicine, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.
authors.forename: Lothar R
authors.initials: LR
authors.lastname: Schad
mesh_terms: D000328:Adult; D001769:Blood / Q000000981:diagnostic imaging*; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D019047:Phantoms, Imaging; D012815:Signal Processing, Computer-Assisted
keywords: MSDE; SAPPHIRE; T1 Mapping; black-blood; partial voluming