title: Cancer and treatment-related symptoms are associated with mobility disability in women with ovarian cancer: A cross-sectional study.
abstract: OBJECTIVE
  To examine the prevalence of symptom-related mobility disability and identify specific symptoms and other factors associated with mobility disability among a national sample of ovarian cancer (OC) survivors.
  
  
  METHODS
  Descriptive, correlational secondary analysis of a National Ovarian Cancer Coalition mailed survey of women with a history of OC (n=713). We used the Symptom Representation Questionnaire (SRQ), the MD Anderson Symptom Inventory (MDASI) Interference Scale, and medical and demographic information to determine prevalence of symptom-related mobility disability. We constructed a multiple linear regression model to determine the relative contributions of specific symptoms and other factors to mobility disability.
  
  
  RESULTS
  A majority of the sample (60.0%) reported symptom-related mobility disability. Independent predictors included: > one comorbidity (β=0.112, p=0.001), active OC (β=0.111, p=0.037), abdominal bloating (β=0.097, p=0.006), fatigue (β=0.314, p<0.001), lack of appetite (β=0.072, p=0.045), numbness/tingling (β=0.134, p<0.001), and pain (β=0.194, p<0.001). The model explained 41.5% of the variance in symptom-related mobility disability (R2=0.415). Unexpectedly, age (β=-0.028, p=0.412) and current chemotherapy (β=0.107, p=0.118) were not significant predictors.
  
  
  CONCLUSIONS
  Symptom-related mobility disability is common among women with OC and is associated with medical comorbidities, abdominal bloating, fatigue, lack of appetite, numbness/tingling, and pain. Longitudinal research should clarify the relationship of these symptoms to mobility disability and determine whether effective symptom management minimizes disability.
authors.affiliation: University of Pittsburgh School of Nursing, 336 Victoria Building, 3500 Victoria Street, Pittsburgh, PA 15261, United States. Electronic address: gbc3@pitt.edu.
authors.forename: Grace
authors.initials: G
authors.lastname: Campbell
authors.affiliation: Massachusetts General Hospital, Harvard Medical School, Yawkey Center, 55 Fruit Street, Boston, MA 02114, United States. Electronic address: thagan@mgh.harvard.edu.
authors.forename: Teresa
authors.initials: T
authors.lastname: Hagan
authors.affiliation: University of Iowa College of Nursing, 50 Newton Road, 444 College of Nursing Building, Iowa City, IA 52242, United States. Electronic address: stephanie-gilbertson-white@uiowa.edu.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Gilbertson-White
authors.affiliation: University of Pittsburgh School of Nursing, 336 Victoria Building, 3500 Victoria Street, Pittsburgh, PA 15261, United States. Electronic address: houzemartin@gmail.com.
authors.forename: Martin
authors.initials: M
authors.lastname: Houze
authors.affiliation: University of Pittsburgh School of Nursing, 336 Victoria Building, 3500 Victoria Street, Pittsburgh, PA 15261, United States. Electronic address: donovanh@pitt.edu.
authors.forename: Heidi
authors.initials: H
authors.lastname: Donovan
mesh_terms: D000328:Adult; D000855:Anorexia / Q000209:etiology / Q000503:physiopathology*; D000970:Antineoplastic Agents / Q000009:adverse effects; D000072716:Cancer Pain / Q000209:etiology / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D005221:Fatigue / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D051346:Mobility Limitation; D010051:Ovarian Neoplasms / Q000150:complications / Q000503:physiopathology*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000503:physiopathology*; D011795:Surveys and Questionnaires
chemical_list: D000970:Antineoplastic Agents
keywords: Disability; Mobility; Ovarian cancer; Physical function; Symptom assessment