title: Cytogenetics in the management of chronic lymphocytic leukemia: an update by the Groupe francophone de cytogénétique hématologique (GFCH).
abstract: Acquired recurrent cytogenetic abnormalities are frequent in chronic lymphocytic leukaemia (CLL). They can be associated with good or poor prognostic factors, and also with gene mutations. Chromosomal abnormalities could be clonal or sub-clonal. Assessing the TP53 status (deletion/mutation) is currently mandatory before treating patients. The search for 11q deletion (ATM gene) is also recommended. Finally, the prognostic value of other chromosomal abnormalities including complex karyotype is still debated.
authors.affiliation: Hôpital Pitié-Salpêtrière, UPMC Paris 6, Inserm UMRS1138, Paris, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Nguyen-Khac
authors.affiliation: Secteur cytogénétique onco-hématologique, Laboratoire d'hématologie, Hôpital Paul Brousse, Villejuif, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Borie
authors.affiliation: Laboratoire de biologie moléculaire et de cytogénétique des hémopathies, Service d'hématologie biologique - CBPAS, Groupement Hospitalier Sud-Hospices Civils de Lyon, Pierre-Bénite, France.
authors.forename: Evelyne
authors.initials: E
authors.lastname: Callet-Bauchu
authors.affiliation: Laboratoire d'hématologie et de cytogénétique, Hôpital Avicenne APHP, Bobigny, France.
authors.forename: Virginie
authors.initials: V
authors.lastname: Eclache
authors.affiliation: Institut universitaire du cancer Toulouse-Oncopole, Laboratoire d'hématologie/Plateau technique hématologie-oncologie, Toulouse, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Struski
mesh_terms: D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis / Q000379:methods / Q000592:standards* / Q000639:trends; D005602:France; D006405:Hematology / Q000458:organization & administration / Q000592:standards / Q000639:trends; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000235:genetics / Q000628:therapy*; D011379:Prognosis; D012955:Societies, Medical / Q000458:organization & administration / Q000592:standards
keywords: 17p deletion; CLL; TP53; cytogenetic abnormalities