title: Benzophenones from Mango Leaves Exhibit α-Glucosidase and NO Inhibitory Activities.
abstract: Mango (Mangifera indica L.) is a succulent tropical fruit. Bioactive phytochemical investigation has been carried out to the leaves of mango. Three new benzophenone glycosides, along with 14 known compounds, were purified and identified. The novel benzophenones were elucidated to be 2,4,4',6-tetrahydroxy-3'-methoxybenzophenone-3-C-β-d-glucopyranoside (1), 4,4',6-trihydroxybenzophenone-2-O-α-l-arabinofuranoside (7), and 4',6-dihydroxy-4-methoxybenzophenone-2-O-(2″),3-C-(1″)-1″-desoxy-α-l-fructofuranoside (11). The α-glucosidase inhibitory, NO production inhibitory, and antioxidant activities were assessed for the purified benzophenones and triterpenoids. Some benzophenones showed moderate α-glucosidase and NO inhibitory activities. The IC50value of the α-glucosidase inhibitory of isolated compounds 1, 13, and 14 were 284.93 ± 20.29, 239.60 ± 25.00, and 297.37 ± 8.12 μM, respectively. Most compounds showed moderate effects to reduce the NO content in 50 and 100 μM. The above results of bioactivity powerfully demonstrated the phytochemicals from mango, especially benzophenones, probably partially rational for its antidiabetes and anti-inflammatory.
authors.affiliation: School of Pharmacy, Guangdong Pharmaceutical University , 280 East Outer Ring Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Pan
authors.affiliation: School of Pharmacy, Guangdong Pharmaceutical University , 280 East Outer Ring Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Yi
authors.affiliation: School of Pharmacy, Guangdong Pharmaceutical University , 280 East Outer Ring Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China.
authors.forename: Yihai
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Pharmacy, Guangdong Pharmaceutical University , 280 East Outer Ring Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China.
authors.forename: Guisi
authors.initials: G
authors.lastname: Chen
authors.affiliation: School of Pharmacy, Guangdong Pharmaceutical University , 280 East Outer Ring Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China.|Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica, State Administration of TCM , Guangzhou 510006, China.
authors.forename: Xiangjiu
authors.initials: X
authors.lastname: He
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D001577:Benzophenones / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D004353:Drug Evaluation, Preclinical / Q000379:methods; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D031022:Mangifera / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D009589:Nitrogen Oxides / Q000378:metabolism*; D018515:Plant Leaves / Q000737:chemistry; D000520:alpha-Glucosidases / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D001577:Benzophenones; D065089:Glycoside Hydrolase Inhibitors; D009589:Nitrogen Oxides; D000520:alpha-Glucosidases
keywords: Mangifera indica; anti-inflammatory; antioxidant; benzophenones; mango; α-glucosidase inhibitory