title: Sarcoidosis-related mortality in France: a multiple-cause-of-death analysis.
abstract: We evaluated mortality rates and underlying causes of death among French decedents with sarcoidosis from 2002 to 2011.We used data from the French Epidemiological Centre for the Medical Causes of Death to 1) calculate sarcoidosis-related mortality rates, 2) examine differences by age and gender, 3) determine underlying and nonunderlying causes of death, 4) compare with the general population (observed/expected ratios), and 5) analyse regional differences.1662 death certificates mentioning sarcoidosis were recorded. The age-standardised mortality rate was 3.6 per million population and significantly increased over the study period. The mean age at death was 70.4 years (versus 76.2 years for the general population). The most common underlying cause of death was sarcoidosis. Sarcoidosis decedents were more likely to be males when aged <65 years. When sarcoidosis was the underlying cause of death, the main other mentions on death certificates were chronic respiratory and cardiovascular diseases. The overall observed/expected ratio was >1 for infectious disease, tuberculosis and chronic respiratory disease, and <1 for neoplasms. We observed a north-south gradient of age-standardised mortality ratio at the country level.Despite the limitation of possibly capturing the more severe cases of sarcoidosis, this study may help define and prioritise preventive interventions.
authors.affiliation: Dept of Internal Medicine, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Université Claude Bernard-Lyon 1, Lyon, France yvanjamilloux@hotmail.com.|These authors contributed equally to this work.
authors.forename: Yvan
authors.initials: Y
authors.lastname: Jamilloux
authors.affiliation: Service de Biostatistiques, Hospices Civils de Lyon, Université Claude Bernard-Lyon 1, Lyon, France.|CNRS UMR5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, Villeurbanne, France.|These authors contributed equally to this work.
authors.forename: Delphine
authors.initials: D
authors.lastname: Maucort-Boulch
authors.affiliation: Dept of Anaesthesiology and Critical Care, Lariboisière University Hospital, AP-HP, Paris, France.|University Denis Diderot - Paris VII, Paris, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Kerever
authors.affiliation: Dept of Internal Medicine, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Université Claude Bernard-Lyon 1, Lyon, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Gerfaud-Valentin
authors.affiliation: Dept of Internal Medicine, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Université Claude Bernard-Lyon 1, Lyon, France.
authors.forename: Christiane
authors.initials: C
authors.lastname: Broussolle
authors.affiliation: INSERM, CépiDc, Le Kremlin-Bicêtre, Paris, France.
authors.forename: Mireille
authors.initials: M
authors.lastname: Eb
authors.affiliation: Assistance Publique - Hôpitaux de Paris, Hôpital Avicenne and Université Paris 13, Sorbonne Paris Cité, Bobigny, France.|These authors contributed equally to this work.
authors.forename: Dominique
authors.initials: D
authors.lastname: Valeyre
authors.affiliation: Dept of Internal Medicine, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Université Claude Bernard-Lyon 1, Lyon, France.|These authors contributed equally to this work.
authors.forename: Pascal
authors.initials: P
authors.lastname: Seve
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002423:Cause of Death; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012507:Sarcoidosis / Q000401:mortality*; D017678:Sex Distribution; D055815:Young Adult