title: Human Hair Reconstruction: Close, But Yet So Far.
abstract: Billions of dollars are annually invested in pharmaceutical industry and cosmetic sector with intent to develop new drugs and treatment strategies for alopecia. Because the hair looks an important characteristic of humans-an effective appendage in perception, expression of beauty, and preservation of self-esteem-the global market for hair loss treatment products is exponentially increasing. However, current methods to treat hair loss endure yet multiple challenges, such as unfavorable outcomes, nonpermanent and patient-dependent results, as well as unpredictable impacts, which limit their application. Over recent years, remarkable advances in the fields of regenerative medicine and hair tissue engineering have raised new hopes for introducing novel cell-based approaches to treat hair loss. Through cell-based approaches, it is possible to produce hair-like structures in the laboratory setting or manipulate cells in their native niche (in vivo lineage reprogramming) to reconstruct the hair follicle. However, challenging issues still exist with the functionality of cultured human hair cells, the proper selection of nonhair cell sources in cases of shortage of donor hair, and the development of defined culture conditions. Moreover, in the case of in vivo lineage reprogramming, selecting appropriate induction factors and their efficient delivery to guide resident cells into a hair fate-with the aim of reconstructing functional hair-still needs further explorations. In this study, we highlight recent advances and current challenges in hair loss treatment using cell-based approaches and provide novel insights for crucial steps, which must be taken into account to develop reproducible, safe, and efficient cell-based treatment.
authors.affiliation: 1 Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology , ACECR, Tehran, Iran .|2 Department of Developmental Biology, University of Science and Culture , Tehran, Iran .
authors.forename: Parvaneh
authors.initials: P
authors.lastname: Mohammadi
authors.affiliation: 3 Department of Developmental Neurobiology, Instituto de Neurociencias CSIC-UMH , San Juan de Alicante, Spain .
authors.forename: Khalil Kass
authors.initials: KK
authors.lastname: Youssef
authors.affiliation: 1 Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology , ACECR, Tehran, Iran .
authors.forename: Saeed
authors.initials: S
authors.lastname: Abbasalizadeh
authors.affiliation: 1 Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology , ACECR, Tehran, Iran .|2 Department of Developmental Biology, University of Science and Culture , Tehran, Iran .
authors.forename: Hossein
authors.initials: H
authors.lastname: Baharvand
authors.affiliation: 1 Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology , ACECR, Tehran, Iran .
authors.forename: Nasser
authors.initials: N
authors.lastname: Aghdami
mesh_terms: D000505:Alopecia / Q000473:pathology / Q000628:therapy; D006197:Hair / Q000502:physiology*; D018859:Hair Follicle / Q000254:growth & development; D006801:Humans; D012038:Regeneration / Q000502:physiology*; D055153:Stem Cell Niche
keywords: alopecia; dermal papilla cells; hair loss; hair regeneration; hair stem cells