title: Interleukin-33 in health and disease.
abstract: Interleukin-33 (IL-33) - a member of the IL-1 family - was originally described as an inducer of type 2 immune responses, activating T helper 2 (TH2) cells and mast cells. Now, evidence is accumulating that IL-33 also potently stimulates group 2 innate lymphoid cells (ILC2s), regulatory T (Treg) cells, TH1 cells, CD8+T cells and natural killer (NK) cells. This pleiotropic nature is reflected in the role of IL-33 in tissue and metabolic homeostasis, infection, inflammation, cancer and diseases of the central nervous system. In this Review, we highlight the molecular and cellular characteristics of IL-33, together with its major role in health and disease and the potential therapeutic implications of these findings in humans.
authors.affiliation: Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow G3 8HF, UK.|School of Biology and Basic Medical Sciences, Soochow University, Suzhou 215006, China.
authors.forename: Foo Yew
authors.initials: FY
authors.lastname: Liew
authors.affiliation: Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, UPS, 31077 Toulouse, France.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Girard
authors.affiliation: Starzl Transplantation Institute, and the Departments of Surgery and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.
authors.forename: Heth Roderick
authors.initials: HR
authors.lastname: Turnquist
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000276:immunology / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D004198:Disease Susceptibility; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate; D056747:Immunomodulation; D007249:Inflammation / Q000209:etiology / Q000378:metabolism; D000067596:Interleukin-33 / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D009369:Neoplasms / Q000209:etiology / Q000378:metabolism; D016377:Organ Transplantation; D012038:Regeneration / Q000235:genetics / Q000276:immunology; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism
chemical_list: D016207:Cytokines; D000067596:Interleukin-33