title: Predictive value of serum cytokine levels in chronic myeloid leukemia patients.
abstract: Serum samples taken at diagnosis in 28 chronic myeloid leukemia patients were tested for the presence of 20 cytokines by a magnetic bead-based Bio-plex immunoassay. According to complete cytogenetic remission achieved at 12 months of treatment, patients were divided into groups with either optimal or non-optimal outcome. Patients with increased cytokine levels tended to react optimally to the therapy more frequently than those others. TGF-β3 was a notable exception; its levels were significantly higher in patients with non-optimal outcomes. Further analysis enabled us to define two combinations of cytokine cut-off levels - namely low TGF-β3 and either high IL-8 or high MCP-1-each of which corresponded to therapy outcome better than either Sokal or EUTOS scores.
authors.affiliation: Department of Immunology, Institute of Hematology and Blood Transfusion, Prague, Czech Republic. Electronic address: martina.petrackova@uhkt.cz.
authors.forename: Martina
authors.initials: M
authors.lastname: Petrackova
authors.affiliation: Department of Immunology, Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
authors.forename: Eva
authors.initials: E
authors.lastname: Hamsikova
authors.affiliation: Department of Immunology, Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
authors.forename: Martina
authors.initials: M
authors.lastname: Duskova
authors.affiliation: Department of Immunology, Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
authors.forename: Pavlina
authors.initials: P
authors.lastname: Ptackova
authors.affiliation: Clinical Department, Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
authors.forename: Hana
authors.initials: H
authors.lastname: Klamova
authors.affiliation: Department of Immunology and Microbiology, 1st Medical Faculty, Charles University, Prague, Czech Republic.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Humlova
authors.affiliation: Department of Immunology, Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Vonka
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood* / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015415:Biomarkers; D016207:Cytokines
keywords: Chronic myeloid leukemia; EUTOS; Prediction reliability; Serum cytokines; Sokal