title: Analysis of the Prognostic Factors of Extensive Disease Small-Cell Lung Cancer Patients in Tokushima University Hospital.
abstract: BACKGROUND
  Small-cell lung cancer (SCLC) presents aggressive clinical behavior, and its prognosis is still poor. Previously, performance status (PS), or the existence of brain, bone, or liver metastasis were reported to be unfavorable prognostic factors. Given the recent progress of treatment modalities such as radiotherapy techniques and bone modifying agents, the prognostic factors might be different from previous findings. Therefore, we analyzed the prognostic factors of extensive disease SCLC (ED-SCLC) in recent years.
  
  
  METHODS
  ED-SCLC patients treated in Tokushima University Hospital between 2010 and 2016 were analyzed. Log-rank test and the Cox proportional hazards regression model was used in univariate and multivariate analysis, respectively.
  
  
  RESULTS
  Totally, 79 patients were analyzed. In the univariate analysis, age, PS, interstitial pneumonia (IP), liver metastasis, pleural dissemination, neutrophil counts, hypoalbuminemia, hypercalcemia and several liver and biliary enzymes were identified as poor prognostic factors. In the multivariate analysis, age, PS, IP, and liver and biliary enzymes were identified. Moreover, the PS in patients with liver metastasis was significantly worsened.
  
  
  CONCLUSIONS
  In this study, we newly demonstrated that IP was a significant poor prognostic factor of ED-SCLC. Although liver metastasis was not extracted in multivariate analysis, it may have an impact on the prognosis of ED-SCLC. J. Med. Invest. 63: 286-293, August, 2016.
authors.affiliation: Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Ogino
authors.forename: Masaki
authors.initials: M
authors.lastname: Hanibuchi
authors.forename: Soji
authors.initials: S
authors.lastname: Kakiuchi
authors.forename: Atsuro
authors.initials: A
authors.lastname: Saijo
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Tezuka
authors.forename: Yuko
authors.initials: Y
authors.lastname: Toyoda
authors.forename: Makoto
authors.initials: M
authors.lastname: Tobiume
authors.forename: Kenji
authors.initials: K
authors.lastname: Otsuka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Sakaguchi
authors.forename: Hisatsugu
authors.initials: H
authors.lastname: Goto
authors.forename: Kokichi
authors.initials: K
authors.lastname: Arisawa
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Nishioka
mesh_terms: D000368:Aged; D005260:Female; D006785:Hospitals, University; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D017563:Lung Diseases, Interstitial / Q000401:mortality; D008175:Lung Neoplasms / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D055752:Small Cell Lung Carcinoma / Q000401:mortality*