title: Clinical and Imaging Outcomes up to 1 Year Following Balloon Angioplasty for Isolated Penile Artery Stenoses in Patients With Erectile Dysfunction: The PERFECT-2 Study.
abstract: To assess the angiographic and clinical outcomes in patients with erectile dysfunction and isolated penile artery stenoses treated by balloon angioplasty.
  
  
  
  In this prospective study, 22 patients (mean age 61.0±7.6 years, range 50-79) with erectile dysfunction and 34 isolated penile artery stenoses (mean 74.9%±9.1%) were enrolled and underwent balloon angioplasty. The mean International Index for Erectile Function-5 (IIEF-5) score at baseline was 10.3±4.5. The mean lesion length was 11.1±9.0 mm (mean reference vessel diameter 1.7±0.4 mm). The primary endpoint was in-segment restenosis ≥50% by pelvic computed tomography angiography (CTA) at 8 months. The 1-year sustained clinical success (IIEF-5 score ≥22 or a ≥4-point change in the IIEF-5 score and no later decline by ≥4) was the secondary outcome measure.
  
  
  
  Procedural success was achieved in 31 (91%) of 34 stenotic lesions; there was 1 flow-limiting dissection and 2 arteries with >30% residual stenosis. At 8 months, 14 of 34 lesions in 13 of 22 patients had CTA-documented binary restenosis. At 1 year, sustained clinical success was achieved in 11 of 22 patients. Of the 9 patients not developing binary restenosis, 8 achieved sustained clinical success.
  
  
  
  Our findings establish the safety and efficacy of penile artery angioplasty for patients with erectile dysfunction and isolated penile artery stenoses. They also highlight the unmet need for a more enduring treatment strategy for penile artery stenotic disease.
authors.affiliation: Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei City, Taiwan tdwang@ntu.edu.tw.
authors.forename: Tzung-Dau
authors.initials: TD
authors.lastname: Wang
authors.affiliation: Department of Medical Imaging, National Taiwan University Hospital, Taipei City, Taiwan.
authors.forename: Wen-Jeng
authors.initials: WJ
authors.lastname: Lee
authors.affiliation: Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin County, Taiwan.
authors.forename: Shao-Chi
authors.initials: SC
authors.lastname: Yang
authors.affiliation: Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei City, Taiwan.
authors.forename: Po-Chih
authors.initials: PC
authors.lastname: Lin
authors.affiliation: Department of Urology, National Taiwan University Hospital, Taipei City, Taiwan.
authors.forename: Huai-Ching
authors.initials: HC
authors.lastname: Tai
authors.affiliation: Department of Urology, National Taiwan University Hospital, Taipei City, Taiwan.
authors.forename: Shih-Ping
authors.initials: SP
authors.lastname: Liu
authors.affiliation: Department of Emergency Medicine, National Taiwan University Hospital, Taipei City, Taiwan.
authors.forename: Chien-Hua
authors.initials: CH
authors.lastname: Huang
authors.affiliation: Department of Emergency Medicine, National Taiwan University Hospital, Taipei City, Taiwan.
authors.forename: Wen-Jone
authors.initials: WJ
authors.lastname: Chen
authors.affiliation: Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei City, Taiwan.
authors.forename: Ming-Fong
authors.initials: MF
authors.lastname: Chen
authors.affiliation: Department of Urology, National Taiwan University Hospital, Taipei City, Taiwan.
authors.forename: Ju-Ton
authors.initials: JT
authors.lastname: Hsieh
mesh_terms: D000368:Aged; D000800:Angioplasty, Balloon / Q000009:adverse effects; D001158:Arteries / Q000000981:diagnostic imaging* / Q000503:physiopathology; D000072226:Computed Tomography Angiography; D003251:Constriction, Pathologic; D006801:Humans; D018783:Impotence, Vasculogenic / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D010410:Penile Erection; D010413:Penis / Q000098:blood supply*; D058729:Peripheral Arterial Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D020127:Recovery of Function; D012008:Recurrence; D013997:Time Factors; D016896:Treatment Outcome; D014654:Vascular Patency
keywords: angiography; angioplasty; computed tomography; erectile dysfunction; penile artery; restenosis