title: Haemodynamic of blood flow through stenotic aortic valve.
abstract: Aortic valve (AV) stenosis is described as the deposition of calcium within the valve leaflets. With the growth of stenosis, haemodynamic, mechanical performances of the AV and blood flow through the valve are changed. In this study, we proposed two fluid-structure interaction (FSI) finite element (FE) models. The hyperelastic material model was considered for leaflets tissue. The leaflet tissue was considered stiffer in stenotic valve than the healthy leaflets because of its calcium content. Therefore, the valve could not open completely and this led to a decrease in the orifice area of the valve. The orifice area decreased from 2.4 cm2for the healthy AV to 1.4 cm2for the stenosis case. Mean pressure gradient increased in mid systole and the axial velocity experienced a three times increment in magnitude. Higher blood shear stress magnitudes were observed in stenotic valve due to the structure of the leaflet. In addition, strain concentration and higher stress values were observed on the leaflets in stenotic valve and the effective stress was greater than healthy case. In addition, pressure and velocity results were consistent with the echocardiography data literature. We have compared the performance of healthy and stenotic AV models during a complete cardiac cycle. Although improvements are still needed, there was good agreement between our computed data and other published studies.
authors.affiliation: a Department of Biomechanics , College of Biomedical Engineering, Tehran Science and Research Branch, Azad Islamic University , Tehran , Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Sadeghpour
authors.affiliation: b Department of Biomechanics, Faculty of Biomedical Engineering , Amirkabir University of Technology (Tehran Polytechnic) , Tehran , Iran.
authors.forename: Nasser
authors.initials: N
authors.lastname: Fatouraee
authors.affiliation: c Department of the Mechanical Engineering , Iran University of Science and Technology , Tehran , Iran.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Navidbakhsh
mesh_terms: D001021:Aortic Valve / Q000503:physiopathology; D001024:Aortic Valve Stenosis / Q000503:physiopathology*; D001783:Blood Flow Velocity / Q000502:physiology*; D002114:Calcinosis / Q000503:physiopathology; D003198:Computer Simulation; D020342:Finite Element Analysis; D006801:Humans; D008955:Models, Cardiovascular
keywords: Aortic valve; mean pressure gradient; stenosis; stress