title: Hippocampal arterial cerebral blood volume in early psychosis.
abstract: Recent studies of patients in the early stage of psychosis have revealed increased cerebral blood volume (CBV) in specific subfields of the anterior hippocampus. These studies required injection of a contrast agent to measure steady state CBV. Here we used a novel, non-invasive method, inflow-based-vascular-space-occupancy with dynamic subtraction (iVASO-DS), to measure the arterial component of CBV (aCBV) in a single slice of the hippocampus. Based on evidence from contrast-enhanced CBV studies, we hypothesized increased aCBV in the anterior hippocampus in early psychosis. We used 3T MRI to generate iVASO-derived aCBV maps in 17 medicated patients (average duration of illness = 7.6 months) and 25 matched controls. We did not find hemispheric or regional group differences in hippocampal aCBV. The limited spatial resolution of the iVASO-DS method did not allow us to test for aCBV differences in specific subfields of the hippocampus. Future studies should investigate venous and arterial CBV changes in the hippocampus of early psychosis patients.
authors.affiliation: Vanderbilt Brain Institute, Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN 37212, USA. Electronic address: pratik.talati@vanderbilt.edu.
authors.forename: Pratik
authors.initials: P
authors.lastname: Talati
authors.affiliation: Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Radiology, University of Washington, Seattle, WA 98195, USA.
authors.forename: Swati
authors.initials: S
authors.lastname: Rane
authors.affiliation: Vanderbilt Brain Institute, Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN 37212, USA; Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
authors.forename: Manus J
authors.initials: MJ
authors.lastname: Donahue
authors.affiliation: Vanderbilt Brain Institute, Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN 37212, USA.
authors.forename: Stephan
authors.initials: S
authors.lastname: Heckers
mesh_terms: D000293:Adolescent; D000328:Adult; D000071937:Cerebral Blood Volume / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D011618:Psychotic Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology*; D055815:Young Adult
keywords: ACBV; Arterial cerebral blood volume; Early psychosis; Hippocampus; IVASO; Inflow-based-vascular-space-occupancy