title: Adverse outcome of coarctation stenting in patients with Turner syndrome.
abstract: OBJECTIVE
  This study examines the outcome and procedural outcomes of percutaneous stent angioplasty for aortic coarctation in patients with Turner syndrome (TS).
  
  
  BACKGROUND
  TS occurs in 1 in 2,500 live-born females and is associated with aortic coarctation.
  
  
  METHODS
  In this multicenter, retrospective cohort study, all patients with TS and a coarctation of the aorta, treated with percutaneous stent implantation were included. The procedural strategies were dictated by local protocols. Adverse events at short- and long-term follow-up and qualitative parameters concerning the stent implantation were assessed.
  
  
  RESULTS
  In the largest study to date of TS patients receiving aortic stents, a total of 19 patients from 10 centers were included. Twelve patients were treated for native and 7 for recurrent coarctation. Age at intervention was 16.9 (7-60) years (median; min-max). The coarctation diameter increased significantly from 8.0 mm (2-12) pre-intervention to 15.0 mm (10-19) post-intervention (P < 0.001). Three (15.8%) adverse events occurred within 30 days of the procedure, including two dissections despite the use of covered stents, one resulting in death. At long-term follow-up (6.5 years, min-max: 1-16), two additional deaths occurred not known to be stent-related.
  
  
  CONCLUSIONS
  Though percutaneous treatment of aortic coarctation in TS patients is effective, it is associated with serious morbidity and mortality. These risks suggest that alternative treatment options should be carefully weighed against percutaneous stenting strategies. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Congenital Cardiology, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Allard T
authors.initials: AT
authors.lastname: van den Hoven
authors.affiliation: Department of Cardiology, UMC Radboud, Nijmegen, The Netherlands.
authors.forename: Anthonie L
authors.initials: AL
authors.lastname: Duijnhouwer
authors.affiliation: Department Pediatric Cardiology and Congenital Heart Disease, German Heart Centre, Munich, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Eicken
authors.affiliation: Ahmanson/UCLA Adult Congenital Heart Disease Center, Ronald Reagan/UCLA Medical Center, Los Angeles, California.
authors.forename: Jamil
authors.initials: J
authors.lastname: Aboulhosn
authors.affiliation: Division of Pediatric Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
authors.forename: Christiaan
authors.initials: C
authors.lastname: de Bruin
authors.affiliation: Division of Pediatric Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
authors.forename: Philippe F
authors.initials: PF
authors.lastname: Backeljauw
authors.affiliation: Department of Cardiology, UZ Gent, Gent, Belgium.
authors.forename: Laurent
authors.initials: L
authors.lastname: Demulier
authors.affiliation: Center for Pediatric and Congenital Cardiology, IRCCS Policlinico, San Donato, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Chessa
authors.affiliation: Department Pediatric Cardiology and Congenital Heart Disease, RBHT, London, United Kingdom.
authors.forename: Anselm
authors.initials: A
authors.lastname: Uebing
authors.affiliation: Division of Pediatric Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
authors.forename: Gruschen R
authors.initials: GR
authors.lastname: Veldtman
authors.affiliation: The Heart Center, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio.
authors.forename: Aimee K
authors.initials: AK
authors.lastname: Armstrong
authors.affiliation: Department of Congenital Cardiology, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Annemien E
authors.initials: AE
authors.lastname: van den Bosch
authors.affiliation: Department of Congenital Cardiology, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Maarten
authors.initials: M
authors.lastname: Witsenburg
authors.affiliation: Department of Congenital Cardiology, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Jolien W
authors.initials: JW
authors.lastname: Roos-Hesselink
mesh_terms: D000293:Adolescent; D000328:Adult; D017130:Angioplasty / Q000009:adverse effects* / Q000295:instrumentation* / Q000401:mortality; D001017:Aortic Coarctation / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D001027:Aortography / Q000379:methods; D002648:Child; D000072226:Computed Tomography Angiography; D005260:Female; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D015607:Stents; D013997:Time Factors; D016896:Treatment Outcome; D014424:Turner Syndrome / Q000150:complications* / Q000175:diagnosis / Q000401:mortality; D055815:Young Adult
keywords: BALA; BMS; CONA; STEC; adults; balloon angioplasty; bare metal; congenital heart disease; stent; stenting technique