title: Placental ABC Transporters: Biological Impact and Pharmaceutical Significance.
abstract: The human placenta fulfills a variety of essential functions during prenatal life. Several ABC transporters are expressed in the human placenta, where they play a role in the transport of endogenous compounds and may protect the fetus from exogenous compounds such as therapeutic agents, drugs of abuse, and other xenobiotics. To date, considerable progress has been made toward understanding ABC transporters in the placenta. Recent studies on the expression and functional activities are discussed. This review discusses the placental expression and functional roles of several members of ABC transporter subfamilies B, C, and G including MDR1/P-glycoprotein, the MRPs, and BCRP, respectively. Since placental ABC transporters modulate fetal exposure to various compounds, an understanding of their functional and regulatory mechanisms will lead to more optimal medication use when necessary in pregnancy.
authors.affiliation: Department of Pharmaceutics, Virginia Commonwealth University School of Pharmacy, Richmond, Virginia, 23298-0533, USA.
authors.forename: Anand A
authors.initials: AA
authors.lastname: Joshi
authors.affiliation: Department of Pharmaceutics, Virginia Commonwealth University School of Pharmacy, Richmond, Virginia, 23298-0533, USA.|Novartis Institutes of Biomedical Research, Cambridge, Massachusetts, USA.
authors.forename: Soniya S
authors.initials: SS
authors.lastname: Vaidya
authors.affiliation: Department of Clinical Pharmacology and Toxicology, University of Zurich Hospital, Zurich, Switzerland.
authors.forename: Marie V
authors.initials: MV
authors.lastname: St-Pierre
authors.affiliation: Department of Pharmaceutics, University of Washington School of Pharmacy, Seattle, Washington, USA.|Department of Neurosurgery, Institute of Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, Washington, 98109, USA.
authors.forename: Andrei M
authors.initials: AM
authors.lastname: Mikheev
authors.affiliation: Department of Pharmaceutical Chemistry, University of Kansas School of Pharmacy, Lawrence, Kansas, USA.|Abbvie Inc, North Chicago, Illinois, USA.
authors.forename: Kelly E
authors.initials: KE
authors.lastname: Desino
authors.affiliation: Department of Pharmaceutics, Virginia Commonwealth University School of Pharmacy, Richmond, Virginia, 23298-0533, USA.
authors.forename: Abner N
authors.initials: AN
authors.lastname: Nyandege
authors.affiliation: Department of Pharmaceutical Chemistry, University of Kansas School of Pharmacy, Lawrence, Kansas, USA.
authors.forename: Kenneth L
authors.initials: KL
authors.lastname: Audus
authors.affiliation: Department of Pharmaceutics, University of Washington School of Pharmacy, Seattle, Washington, USA.
authors.forename: Jashvant D
authors.initials: JD
authors.lastname: Unadkat
authors.affiliation: Department of Pharmaceutics, Virginia Commonwealth University School of Pharmacy, Richmond, Virginia, 23298-0533, USA. pmgerk@vcu.edu.
authors.forename: Phillip M
authors.initials: PM
authors.lastname: Gerk
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics / Q000378:metabolism; D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D016207:Cytokines / Q000378:metabolism; D005260:Female; D006728:Hormones / Q000378:metabolism; D006801:Humans; D008431:Maternal-Fetal Exchange; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism; D010920:Placenta / Q000187:drug effects* / Q000378:metabolism; D011110:Polymorphism, Genetic; D011247:Pregnancy; D015262:Xenobiotics / Q000378:metabolism
chemical_list: D018435:ATP Binding Cassette Transporter, Subfamily B; D018528:ATP-Binding Cassette Transporters; D016207:Cytokines; D006728:Hormones; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D004364:Pharmaceutical Preparations; D015262:Xenobiotics
keywords: P-glycoprotein; breast cancer resistance protein; drug transport; multidrug resistance-associated protein; placenta; regulation of expression