title: Hyperferritinemia increases the risk of hyperuricemia in HFE-hereditary hemochromatosis.
abstract: OBJECTIVE
  Hyperuricemia is becoming increasingly frequent in the population, and is known to be sometimes the cause of gout. The impact of uric acid is still not clearly understood, however. The iron metabolism may interact with the uric acid metabolism. The aim of this study was to examine the relationship between the serum uric acid and serum ferritin levels in a cohort of hemochromatosis patients who were homozygous for the HFE p.Cys282Tyr mutation.
  
  
  METHODS
  738 patients with the HFE gene mutation Cys282Tyr in the homozygous state were included in the study. The variables measured during the initial evaluation were compared in univariate analysis by Student's t test. In multivariate analysis, linear stepwise regression was used.
  
  
  RESULTS
  In the group of hyperuricemic patients, ferritinemia was significantly higher than in the group of non-hyperuricemic patients (1576.7±1387.4μg/l vs. 1095.63±1319.24μg/l, P<0.005). With multivariate analysis, only ferritin and BMI independently explained the uricemia (R2=0.258) after adjustment for age, glycemia and CRP. The correlation between uricemia and log(ferritin) with partial regression correlation coefficients was 0.307 (P<0.01).
  
  
  CONCLUSIONS
  The increase in uricemia is associated with the increase in ferritin in a population of patients who were homozygous for the HFE gene mutation p.Cys282Tyr and this independently of factors commonly associated with hyperuricemia. The increase in uric acid associated with hyperferritinemia, could be a response to the visceral toxicity of excess non-transferrin bound iron linked to oxidative stress via the antioxidant properties of uric acid.
authors.affiliation: Rheumatology Department, Rennes University Hospital, 16, bd de Bulgarie, 35203 Rennes, France. Electronic address: jeremyflais@gmail.com.
authors.forename: Jérémy
authors.initials: J
authors.lastname: Flais
authors.affiliation: INSERM UMR 991, 35000 Rennes, France; University Rennes 1, Medicine Faculty, 35043 Rennes, France; Reference Centre for Rare Genetic Iron Overload Disorders, Clinic for Liver Disorders, Rennes University Hospital, Pontchaillou Hospital, 2 rue Henri Le Guilloux, 35033 Rennes, France.
authors.forename: Edouard
authors.initials: E
authors.lastname: Bardou-Jacquet
authors.affiliation: University Rennes 1, Medicine Faculty, 35043 Rennes, France; Reference Centre for Rare Genetic Iron Overload Disorders, Clinic for Liver Disorders, Rennes University Hospital, Pontchaillou Hospital, 2 rue Henri Le Guilloux, 35033 Rennes, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Deugnier
authors.affiliation: Rheumatology Department, Rennes University Hospital, 16, bd de Bulgarie, 35203 Rennes, France; University Rennes 1, Medicine Faculty, 35043 Rennes, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Coiffier
authors.affiliation: Rheumatology Department, Rennes University Hospital, 16, bd de Bulgarie, 35203 Rennes, France; University Rennes 1, Medicine Faculty, 35043 Rennes, France.
authors.forename: Aleth
authors.initials: A
authors.lastname: Perdriger
authors.affiliation: Rheumatology Department, Rennes University Hospital, 16, bd de Bulgarie, 35203 Rennes, France; University Rennes 1, Medicine Faculty, 35043 Rennes, France.
authors.forename: Gérard
authors.initials: G
authors.lastname: Chalès
authors.affiliation: INSERM UMR 991, 35000 Rennes, France; Reference Centre for Rare Genetic Iron Overload Disorders, Clinic for Liver Disorders, Rennes University Hospital, Pontchaillou Hospital, 2 rue Henri Le Guilloux, 35033 Rennes, France.
authors.forename: Martine
authors.initials: M
authors.lastname: Ropert
authors.affiliation: INSERM UMR 991, 35000 Rennes, France; Reference Centre for Rare Genetic Iron Overload Disorders, Clinic for Liver Disorders, Rennes University Hospital, Pontchaillou Hospital, 2 rue Henri Le Guilloux, 35033 Rennes, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Loréal
authors.affiliation: Rheumatology Department, Rennes University Hospital, 16, bd de Bulgarie, 35203 Rennes, France; INSERM UMR 991, 35000 Rennes, France; University Rennes 1, Medicine Faculty, 35043 Rennes, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Guggenbuhl
mesh_terms: D000328:Adult; D005260:Female; D005293:Ferritins / Q000097:blood*; D006432:Hemochromatosis / Q000097:blood / Q000235:genetics*; D000071020:Hemochromatosis Protein / Q000235:genetics*; D006801:Humans; D033461:Hyperuricemia / Q000097:blood*; D019189:Iron Metabolism Disorders / Q000097:blood; D008297:Male; D008875:Middle Aged; D009154:Mutation; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: C103673:HFE protein, human; D000071020:Hemochromatosis Protein; D014527:Uric Acid; D005293:Ferritins
keywords: Hemochromatosis; Hyperferritinemia; Hyperuricemia; Oxidative stress