title: GPS for QSP: A Summary of the ACoP6 Symposium on Quantitative Systems Pharmacology and a Stage for Near-Term Efforts in the Field.
abstract: Quantitative Systems Pharmacology (QSP) is experiencing increased application in the drug discovery and development process. Like its older sibling, systems biology, the QSP field is comprised of a mix of established disciplines and methods, from molecular biology to engineering to pharmacometrics. As a result, there exist critical segments of the discipline that differ dramatically in approach and a need to bring these groups together toward a common goal.
authors.affiliation: Cardiovascular and Metabolic Diseases Research Unit, Pfizer Inc., Cambridge, Massachusetts, USA.
authors.forename: C J
authors.initials: CJ
authors.lastname: Musante
authors.affiliation: Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Abernethy
authors.affiliation: Quantitative Pharmacology and Pharmacometrics, Merck Research Labs, Merck & Co, Rahway, New Jersey, USA.
authors.forename: S R
authors.initials: SR
authors.lastname: Allerheiligen
authors.affiliation: Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Lauffenburger
authors.affiliation: Quantitative Sciences, Janssen Research and Development, San Diego, California, USA. mzager1@its.jnj.com.
authors.forename: M G
authors.initials: MG
authors.lastname: Zager
mesh_terms: D000818:Animals; D003226:Congresses as Topic / Q000639:trends; D004219:District of Columbia; D055808:Drug Discovery / Q000379:methods* / Q000639:trends; D006801:Humans; D013597:Systems Analysis; D049490:Systems Biology / Q000379:methods* / Q000639:trends