title: Aortic valve replacement in a patient with MPO-ANCA-positive Goodpasture disease.
abstract: Goodpasture disease (GD) is a rare autoimmune disorder characterized by the development of pathologic autoantibodies against both glomerular and alveolar basal membranes. Approximately one third of the patients with GD are also positive for anti-neutrophil cytoplasmic antibody (ANCA). In this case report, a 74-year-old woman was diagnosed as having myeloperoxidase (MPO)-ANCA-positive GD with severe aortic valve stenosis (AS). She underwent immunosuppressive therapy and plasmapheresis that led to GD remission. Whether a cardiac surgery affects a MPO-ANCA-positive GD in remission is unknown. We reported the outcomes after aortic valve replacement for severe AS in a patient with MPO-ANCA-positive GD.
authors.affiliation: Department of Cardiovascular Surgery, Tokyo Women's Medical University Medical Center East, 2-1-10, Nishiogu, Arakawa-ku, 116-8567, Tokyo, Japan. kataokago@yahoo.co.jp.
authors.forename: Go
authors.initials: G
authors.lastname: Kataoka
authors.affiliation: Department of Cardiovascular Surgery, Tokyo Women's Medical University Medical Center East, 2-1-10, Nishiogu, Arakawa-ku, 116-8567, Tokyo, Japan.
authors.forename: Ryota
authors.initials: R
authors.lastname: Asano
authors.affiliation: Department of Cardiovascular Surgery, Tokyo Women's Medical University Medical Center East, 2-1-10, Nishiogu, Arakawa-ku, 116-8567, Tokyo, Japan.
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Sato
authors.affiliation: Department of Cardiovascular Surgery, Tokyo Women's Medical University Medical Center East, 2-1-10, Nishiogu, Arakawa-ku, 116-8567, Tokyo, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Tatsuishi
authors.affiliation: Department of Cardiovascular Surgery, Tokyo Women's Medical University Medical Center East, 2-1-10, Nishiogu, Arakawa-ku, 116-8567, Tokyo, Japan.
authors.forename: Kiyoharu
authors.initials: K
authors.lastname: Nakano
keywords: Goodpasture disease; Interstitial pneumonia; MPO-ANCA