title: Radiation-induced Leiomyosarcoma of the Oral Cavity: A Rare Occurrence Detected on 18F-FDG PET/CT.
abstract: Radiation-induced sarcomas (RIS) or postirradiation sarcomas have been reported as a rare long-term complication of radiation therapy (RT). The survival benefit offered by radiotherapy has been masked by an increase in the incidence of these sarcomas, thus making radiotherapy a double-edged sword. RIS generally develop with a mean latency period of 10-15 years and encompass different histological types. We report a case of oral leiomyosarcoma with a rather short latency period of 4 years after the radiotherapy of the prior oral squamous cell carcinoma (OSCC) detected on fluorine-18 (18F)-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT). The rarity of occurrence of leiomyosarcoma in the oral cavity is also highlighted.
authors.affiliation: Department of Pathology, National Institute of Pathology, Indian Council of Medical Research, New Delhi, India.
authors.forename: Fouzia
authors.initials: F
authors.lastname: Siraj
authors.affiliation: Department of Pathology, National Institute of Pathology, Indian Council of Medical Research, New Delhi, India.
authors.forename: Varsha
authors.initials: V
authors.lastname: Dalal
authors.affiliation: Department of Pathology, National Institute of Pathology, Indian Council of Medical Research, New Delhi, India.
authors.forename: Manveen
authors.initials: M
authors.lastname: Kaur
authors.affiliation: Department of Radiotherapy, Safdarjung Hospital, New Delhi, India.
authors.forename: Kapil
authors.initials: K
authors.lastname: Suri
keywords: Leiomyosarcoma; oral cavity; radiation; squamous cell carcinoma