title: Potential of Surface Enhanced Raman Spectroscopy (SERS) in Therapeutic Drug Monitoring (TDM). A Critical Review.
abstract: Surface-Enhanced Raman Spectroscopy (SERS) is a label-free technique that enables quick monitoring of substances at low concentrations in biological matrices. These advantages make it an attractive tool for the development of point-of-care tests suitable for Therapeutic Drug Monitoring (TDM) of drugs with a narrow therapeutic window, such as chemotherapeutic drugs, immunosuppressants, and various anticonvulsants. In this article, the current applications of SERS in the field of TDM for cancer therapy are discussed in detail and illustrated according to the different strategies and substrates. In particular, future perspectives are provided and special concerns regarding the standardization of self-assembly methods and nanofabrication procedures, quality assurance, and technology readiness are critically evaluated.
authors.affiliation: Department of Engineering and Architecture, University of Trieste, Via Valerio 6a, 34127 Trieste, Italy. ajaworska@units.it.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Jaworska
authors.affiliation: Department of Engineering and Architecture, University of Trieste, Via Valerio 6a, 34127 Trieste, Italy. sfornasaro@units.it.
authors.forename: Stefano
authors.initials: S
authors.lastname: Fornasaro
authors.affiliation: Department of Engineering and Architecture, University of Trieste, Via Valerio 6a, 34127 Trieste, Italy. sergo@units.it.
authors.forename: Valter
authors.initials: V
authors.lastname: Sergo
authors.affiliation: Department of Engineering and Architecture, University of Trieste, Via Valerio 6a, 34127 Trieste, Italy. abonifacio@units.it.
authors.forename: Alois
authors.initials: A
authors.lastname: Bonifacio
keywords: Individualized cancer chemotherapy; SERS; TDM; drug monitoring