title: Paraffin-embedded micrographic surgery for the treatment of dermatofibrosarcoma protuberans: Analysis of 33 patients.
abstract: BACKGROUND
  Dermatofibrosarcoma protuberans is a rare malignant tumor with a high rate of recurrence after surgery. Moh's micrographic surgery allows examination of all surgical margins to ensure complete removal.
  
  
  OBJECTIVE
  To evaluate the use of Moh's micrographic surgery using paraffin-embedded sections for the treatment of dermatofibrosarcoma protuberans.
  
  
  METHODS
  We performed a retrospective analysis of 33 patients with dermatofibrosarcoma protuberans treated in our department with paraffin-embedded micrographic surgery between January 2002 and June 2015. Our cases included patients with primary untreated disease and also those with persistent disease previously treated surgically elsewhere, with histologically positive margins.
  
  
  RESULTS
  Tumors were most commonly located on the trunk. After the first stage of micrographic surgery, including an initial lateral margin, 20 (60.6%) tumors were completely excised, 11 (33.3%) tumors required two stages and one tumor each (3.0%) required 4 and 6 stages respectively. Patients were monitored for recurrence for a mean duration of 6.5 years. There was no recurrence in any of our 33 patients.
  
  
  CONCLUSIONS
  Our results indicate that Moh's micrographic surgery with paraffin-embedded sections may be the method of choice to treat dermatofibrosarcoma protuberans with a low recurrence rate, while preserving surrounding normal healthy tissue.
authors.affiliation: Department of Dermatology, Hospital Universitario de Guadalajara, Guadalajara, Spain.
authors.forename: Adriana
authors.initials: A
authors.lastname: Martín-Fuentes
authors.affiliation: Department of Dermatology, Hospital Universitario de Guadalajara, Guadalajara, Spain.
authors.forename: Esther
authors.initials: E
authors.lastname: De Eusebio-Murillo
authors.affiliation: Department of Dermatology, Hospital Universitario de Guadalajara, Guadalajara, Spain.
authors.forename: Consuelo Sánchez
authors.initials: CS
authors.lastname: Herreros
authors.affiliation: Department of Dermatology, Hospital Universitario de Guadalajara, Guadalajara, Spain.
authors.forename: Adrian
authors.initials: A
authors.lastname: Ballano-Ruiz
authors.affiliation: Department of Dermatology, Hospital Universitario de Guadalajara, Guadalajara, Spain.
authors.forename: Esther Jiménez
authors.initials: EJ
authors.lastname: Blázquez
authors.affiliation: Department of Pathology, Hospital Universitario de Guadalajara, Guadalajara, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Cuevas-Santos
mesh_terms: D000328:Adult; D018223:Dermatofibrosarcoma / Q000175:diagnosis* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015580:Mohs Surgery / Q000379:methods*; D016612:Paraffin Embedding / Q000379:methods*; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: Dermatofibrosarcoma protuberans; Moh's micrographic surgery; paraffin-embedded sections