title: A single-nucleotide polymorphism in MMP9 is associated with decreased risk of steroid-induced osteonecrosis of the femoral head.
abstract: Osteonecrosis of the femoral head (ONFH) is a common hip joint disease, and steroid-induced ONFH accounts for a large number of cases. Here, we examined eight previously-identified single-nucleotide polymorphisms (SNPs) in the MPP2 and MPP9 genes of 285 steroid-induced ONFH patients and 507 healthy controls from northern China to determine whether these SNPs were associated with the risk of developing steroid-induced ONFH. Chi-squared tests and genetic model and haplotype analyses were used to evaluate associations. The rs2274755 SNP in MMP9 was associated with a decreased risk of steroid-induced ONFH in the allele, dominant, and additive models. Additionally, the "CGC" MMP9 haplotype was associated with a 0.69-fold decrease in the risk of steroid-induced ONFH. Although additional, larger population-based studies are needed to confirm these findings, our results reveal for the first time an association between a MMP9 SNP at the rs2274755 locus and a decreased risk of steroid-induced ONFH in a northern Chinese population.
authors.affiliation: Inner Mongolia Medical University, Hohhot, Inner Mongolia, 010050, China.|Department of Orthopedics and Traumatology, The 2th Affiliated Hospital of Inner Mongolia University, Hohhot, Inner Mongolia, 010030, China.
authors.forename: Jieli
authors.initials: J
authors.lastname: Du
authors.affiliation: Department of Orthopedics and Traumatology, The 2th Affiliated Hospital of Inner Mongolia University, Hohhot, Inner Mongolia, 010030, China.
authors.forename: Wanlin
authors.initials: W
authors.lastname: Liu
authors.affiliation: The College of Life Sciences Northwest University, 710069, China.
authors.forename: Tianbo
authors.initials: T
authors.lastname: Jin
authors.affiliation: Department of Orthopedics and Traumatology, The 2th Affiliated Hospital of Inner Mongolia University, Hohhot, Inner Mongolia, 010030, China.
authors.forename: Zhenqun
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: Department of Orthopedics and Traumatology, The 2th Affiliated Hospital of Inner Mongolia University, Hohhot, Inner Mongolia, 010030, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Bai
authors.affiliation: Department of Orthopedics and Traumatology, The 2th Affiliated Hospital of Inner Mongolia University, Hohhot, Inner Mongolia, 010030, China.
authors.forename: Huiqin
authors.initials: H
authors.lastname: Xue
authors.affiliation: Inner Mongolia Medical University, Hohhot, Inner Mongolia, 010050, China.|Department of Orthopedics and Traumatology, The 2th Affiliated Hospital of Inner Mongolia University, Hohhot, Inner Mongolia, 010030, China.
authors.forename: Junyu
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Orthopedics and Traumatology, The 2th Affiliated Hospital of Inner Mongolia University, Hohhot, Inner Mongolia, 010030, China.
authors.forename: Mingqi
authors.initials: M
authors.lastname: Sun
authors.affiliation: The College of Life Sciences Northwest University, 710069, China.
authors.forename: Xiyang
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Orthopedics and Traumatology, The 2th Affiliated Hospital of Inner Mongolia University, Hohhot, Inner Mongolia, 010030, China.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Orthopedics and Traumatology, The 2th Affiliated Hospital of Inner Mongolia University, Hohhot, Inner Mongolia, 010030, China.
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Wang
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China; D005260:Female; D005271:Femur Head Necrosis / Q000139:chemically induced / Q000208:ethnology / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013256:Steroids
chemical_list: D013256:Steroids; D020780:Matrix Metalloproteinase 9
keywords: MMP2; MMP9; association study; osteonecrosis of the femoral head; single nucleotide polymorphisms