title: Non-invasive fecal microbiota transplantation for recurrent Clostridium difficile infection in a patient presenting with hypertensive disorder post interventionem.
abstract: Fecal microbiota transplantation has gathered much attention due to its high efficacy in resolving recurrentClostridium difficileinfection. Until today, it is recognized as a safe procedure without any severe side effects. Patients with impaired conscious states suffering from recurrent episodes of aspiration are at increased risk by endoscopic interventions needed during standard approaches for fecal microbiota transplantation application.Here, we illustrate the case of a tetraplegic patient undergoing fecal microbiota transplantation due to his fifth recurrent episode ofClostridium difficileinfection using a self-advancing nasal jejunal feeding tube as effective minimal-invasive option of fecal microbiota transplantation application. Persistent aggravation of arterial hypertension, which developed post-intervention in this patient, could be interpreted as a hitherto unknown side effect of fecal microbiota transplantation in this setting. Moreover, this is a further hint for a link between the intestinal microbiome and arterial hypertension in general.
authors.affiliation: Medizinische Klinik und Poliklinik I, Universitätsklinikum Bonn, Bonn.
authors.forename: F
authors.initials: F
authors.lastname: Goeser
authors.affiliation: Medizinische Klinik und Poliklinik I, Universitätsklinikum Bonn, Bonn.
authors.forename: S
authors.initials: S
authors.lastname: Schlabe
authors.affiliation: Medizinische Klinik und Poliklinik I, Universitätsklinikum Bonn, Bonn.
authors.forename: C E
authors.initials: CE
authors.lastname: Ruiner
authors.affiliation: Radiologische Klinik, Universitätsklinikum Bonn, Bonn.
authors.forename: L
authors.initials: L
authors.lastname: Kramer
authors.affiliation: Medizinische Klinik und Poliklinik I, Universitätsklinikum Bonn, Bonn.
authors.forename: C P
authors.initials: CP
authors.lastname: Strassburg
authors.affiliation: Medizinische Klinik und Poliklinik I, Universitätsklinikum Bonn, Bonn.
authors.forename: U
authors.initials: U
authors.lastname: Spengler
mesh_terms: D000369:Aged, 80 and over; D016360:Clostridioides difficile; D004750:Enteral Nutrition; D004761:Enterocolitis, Pseudomembranous / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D000069467:Fecal Microbiota Transplantation / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods*; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D008297:Male; D012008:Recurrence; D016896:Treatment Outcome