title: The Role of EphA4 Signaling in Radiation-Induced EMT-Like Phenotype in Colorectal Cancer Cells.
abstract: Radiotherapy is widely used for advanced rectal tumors. However, refractory metastasis has become the major cause of therapy failure in rectal cancer patients. Understanding the molecular mechanism that controls the aggressive cellular response to this treatment is essential for developing new therapeutic applications and improving radiotherapy response in colorectal cancer patients. Using the progeny of cells that were submitted to irradiation, we have demonstrated that the PI3K/AKT, Wnt/β-catenin signaling pathways as well as ERK1/2 downstream of EPHA4 receptor activation, play an important role in the regulation of events related with the EMT development, which may be associated with the therapeutic failure in rectal cancer after radiotherapy. Here, we further discuss about EphA4 receptor as a potential therapeutic target for the treatment of this cancer type. J. Cell. Biochem. 118: 442-445, 2017. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Cellular Biology Program, Brazilian National Cancer Institute (INCA), 37 André Cavalcanti Street, 5th Floor, Rio de Janeiro, RJ 20230-051, Brazil.
authors.forename: Priscila Guimarães
authors.initials: PG
authors.lastname: de Marcondes
authors.affiliation: Cellular Biology Program, Brazilian National Cancer Institute (INCA), 37 André Cavalcanti Street, 5th Floor, Rio de Janeiro, RJ 20230-051, Brazil.
authors.forename: José Andrés
authors.initials: JA
authors.lastname: Morgado-Díaz
mesh_terms: D058750:Epithelial-Mesenchymal Transition / Q000235:genetics / Q000528:radiation effects*; D006801:Humans; D020935:MAP Kinase Signaling System / Q000235:genetics / Q000528:radiation effects*; D019950:Mitogen-Activated Protein Kinase 1 / Q000235:genetics / Q000378:metabolism; D048052:Mitogen-Activated Protein Kinase 3 / Q000235:genetics / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics / Q000378:metabolism; D036122:Receptor, EphA4 / Q000235:genetics / Q000378:metabolism*; D012004:Rectal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000532:radiotherapy*; D060449:Wnt Signaling Pathway / Q000235:genetics / Q000528:radiation effects*
chemical_list: D019869:Phosphatidylinositol 3-Kinases; D036122:Receptor, EphA4; D051057:Proto-Oncogene Proteins c-akt; C535150:MAPK1 protein, human; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3
keywords: COLORECTAL CANCER; EPITHELIAL-TO-MESENCHYMAL-TRANSITION; EphA4 RECEPTOR; RADIOTHERAPY; SIGNALING PATHWAYS