title: Low expression of DCXR protein indicates a poor prognosis for hepatocellular carcinoma patients.
abstract: The aim of this study was to investigate the prognostic value of dicarbonyl/L-xylulose reductase (DCXR) in human hepatocellular carcinoma (HCC). Immunohistochemistry and tissue microarrays were used to evaluate DCXR protein expression levels. Image-Pro Plus was used to calculate the integral optic density (IOD) in each tissue sample, which represented the expression level of DCXR. DCXR proteins were found to be significantly lower in HCC tumor tissues (P < 0.0001) according to immunohistochemical analysis of DCXR protein levels in 74 paired HCC tissue and peritumoral non-cancer tissues. The prognostic value of DCXR in HCC was assessed in 290 cases of the training cohort and 74 cases of the validation cohort. Shorter overall survival (OS) time and shorter time to recurrence (TTR) in both the training and validation set were found to be associated with lower expression levels of DCXR. In the training set, the expression level of DCXR in HCC was an independent prognostic factor for OS according to univariate and multivariate analyses. In conclusion, DCXR expression is an independent prognostic factor for OS and TTR of post-operative HCC patients, and low expression levels of DCXR in HCC may indicate poor outcome of HCC patients after surgical resection.
authors.affiliation: Department of Infection Diseases, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, 200003, Shanghai, People's Republic of China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Hang
authors.affiliation: Department of Infection Diseases, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, 200003, Shanghai, People's Republic of China.
authors.forename: Zhiqin
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department VI of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 225 Changhai Road, 200433, Shanghai, People's Republic of China.
authors.forename: Kaijian
authors.initials: K
authors.lastname: Chu
authors.affiliation: Department of Oncology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, 200003, Shanghai, People's Republic of China.
authors.forename: Guanzhen
authors.initials: G
authors.lastname: Yu
authors.affiliation: Department of Microbiology, Second Military Medical University, 8 Panshan Road, 200433, Shanghai, People's Republic of China.
authors.forename: Haoran
authors.initials: H
authors.lastname: Peng
authors.affiliation: Department of Infection Diseases, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, 200003, Shanghai, People's Republic of China.
authors.forename: Haiguang
authors.initials: H
authors.lastname: Xin
authors.affiliation: Department of Infection Diseases, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, 200003, Shanghai, People's Republic of China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Miao
authors.affiliation: Department of Infection Diseases, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, 200003, Shanghai, People's Republic of China. docd1@sina.com.
authors.forename: Junxue
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Infection Diseases, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, 200003, Shanghai, People's Republic of China. xuws@medinfect.com.
authors.forename: Wensheng
authors.initials: W
authors.lastname: Xu
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D013401:Sugar Alcohol Dehydrogenases / Q000378:metabolism*; D015996:Survival Rate; D046888:Tissue Array Analysis
chemical_list: D014408:Biomarkers, Tumor; D013401:Sugar Alcohol Dehydrogenases; C023300:L-xylulose reductase
keywords: Dicarbonyl/L-xylulose reductase; Hepatocellular carcinoma; Prognosis; Tissue microarray