title: THBS2 is a Potential Prognostic Biomarker in Colorectal Cancer.
abstract: Colorectal cancer is one of the most common leading causes of death worldwide. Prognostic at an early stage is a useful way that decrease and avoid mortality. Although remarkable progress has been made to investigate the underlying mechanism, the understanding of the complicated carcinogenesis process was enormously hindered by large-scale tumor heterogeneity. Here we proposed that the prognosis-related gene THBS2, responsible for cooperativity disorientation, probably contain untapped prognostic resource of colorectal cancer. We originally established Spearman correlation transition, Kaplan-Meier survival analysis and meta-analysis that combine public dataset and clinical samples to quantify the prognostic value of THBS2. THBS2 could be considered as a novel prognostic marker in colorectal cancer.
authors.affiliation: Department of Pharmacology, China Pharmaceutical University, Nanjing, 210009, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Pharmacology, China Pharmaceutical University, Nanjing, 210009, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Pathology, School of Medicine, Zhejiang University, Hangzhou 310058, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Pathology, School of Medicine, Zhejiang University, Hangzhou 310058, China.
authors.forename: WenJie
authors.initials: W
authors.lastname: Sun
authors.affiliation: Department of Pathology, School of Medicine, Zhejiang University, Hangzhou 310058, China.|Key Laboratory of Disease Proteomics of Zhejiang Province, Hangzhou 310058, China.
authors.forename: Honghe
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Pharmacology, China Pharmaceutical University, Nanjing, 210009, China.|Department of Pathology, School of Medicine, Zhejiang University, Hangzhou 310058, China.|Key Laboratory of Disease Proteomics of Zhejiang Province, Hangzhou 310058, China.
authors.forename: Maode
authors.initials: M
authors.lastname: Lai
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D049109:Cell Proliferation; D016000:Cluster Analysis; D015179:Colorectal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D019992:Databases as Topic; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D045325:HCT116 Cells; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis; D016016:Proportional Hazards Models; D015203:Reproducibility of Results; D019699:Thrombospondins / Q000235:genetics / Q000378:metabolism*; D000099262:Thrombospondin 2
chemical_list: D014408:Biomarkers, Tumor; D019699:Thrombospondins; D000099262:Thrombospondin 2