title: Hypothermia in Traumatic Brain Injury.
abstract: For over 50 years, clinicians have used hypothermia to manage traumatic brain injury (TBI). In the last two decades numerous trials have assessed whether hypothermia is of benefit in patients. Mild to moderate hypothermia reduces the intracranial pressure (ICP). Randomized control trials for short-term hypothermia indicate no benefit in outcome after severe TBI, whereas longer-term hypothermia could be of benefit by reducing ICP. This article summarises current evidence and gives recommendations based upon the conclusions.
authors.affiliation: Miami Project to Cure Paralysis, Lois Pope Life Center, University of Miami, 1095 Northwest, 14th Terrace, Miami, FL 33136, USA. Electronic address: a.ahmed@soton.ac.uk.
authors.forename: Aminul I
authors.initials: AI
authors.lastname: Ahmed
authors.affiliation: Miami Project to Cure Paralysis, Lois Pope Life Center, University of Miami, 1095 Northwest, 14th Terrace, Miami, FL 33136, USA.
authors.forename: M Ross
authors.initials: MR
authors.lastname: Bullock
authors.affiliation: Miami Project to Cure Paralysis, Lois Pope Life Center, University of Miami, 1095 Northwest, 14th Terrace, Miami, FL 33136, USA.
authors.forename: W Dalton
authors.initials: WD
authors.lastname: Dietrich
mesh_terms: D001921:Brain / Q000503:physiopathology*; D000070642:Brain Injuries, Traumatic / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D007427:Intracranial Pressure / Q000502:physiology*; D016896:Treatment Outcome
keywords: Hypothermia; Intracranial pressure; Neuroprotection; Traumatic brain injury