title: Role of CD46 Polymorphisms in the Occurrence of Disease in Young Chinese Men With Human Adenovirus Type 55 Infection.
abstract: Human adenovirus type 55 (HAdV-55) has recently caused multiple outbreaks. This study examined polymorphisms in CD46 to determine their involvement in HAdV-55 infection.
  
  
  
  A total of 214 study subjects infected with HAdV-55 were included in our study. The study subjects were divided into those with silent infections (n=91), minor infections (n=85), and severe infections (n=38). Ten single nucleotide polymorphisms (SNPs) from CD46 were examined.
  
  
  
  Compared with the AA genotype, the TT genotype at rs2724385 (CD46, A/T) was associated with a protective effect against disease occurrence, with an odds ratio (95% confidence interval) of 0.20 (0.04-0.97) (P=0.038). There were no significant differences between the patients with minor and severe infection and those who had silent HAdV-55 infection in the other CD46 SNPs. We next compared the polymorphisms of these genes according to disease severity in HAdV-55-infected patients with clinical symptoms. The results showed that there were no significant differences between minor infections and severe infections.
  
  
  
  Our results suggested that the CD46 SNP at rs2724385 is associated with the occurrence of disease in HAdV-55-infected patients. A much larger number of samples is required to understand the role of CD46 polymorphisms in the occurrence and progression of infection by HAdV-55. (Disaster Med Public Health Preparedness. 2018;12:427-430).
authors.affiliation: 1Institute of Disaster Medicine and Public Health,Affiliated Hospital of the Logistic University of the Chinese People's Armed Police Force (PAP),Tianjin,China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Lv
authors.affiliation: 2Key Laboratory of Emergency and Disaster Medicine in the Chinese People's Liberation Army (PLA),Tianjin,China.
authors.forename: Hui
authors.initials: H
authors.lastname: Ding
authors.affiliation: 1Institute of Disaster Medicine and Public Health,Affiliated Hospital of the Logistic University of the Chinese People's Armed Police Force (PAP),Tianjin,China.
authors.forename: Zi-Quan
authors.initials: ZQ
authors.lastname: Liu
authors.affiliation: 1Institute of Disaster Medicine and Public Health,Affiliated Hospital of the Logistic University of the Chinese People's Armed Police Force (PAP),Tianjin,China.
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Gao
authors.affiliation: 1Institute of Disaster Medicine and Public Health,Affiliated Hospital of the Logistic University of the Chinese People's Armed Police Force (PAP),Tianjin,China.
authors.forename: Bao-Guo
authors.initials: BG
authors.lastname: Yu
authors.affiliation: 1Institute of Disaster Medicine and Public Health,Affiliated Hospital of the Logistic University of the Chinese People's Armed Police Force (PAP),Tianjin,China.
authors.forename: Zhou-Wei
authors.initials: ZW
authors.lastname: Wu
authors.affiliation: 1Institute of Disaster Medicine and Public Health,Affiliated Hospital of the Logistic University of the Chinese People's Armed Police Force (PAP),Tianjin,China.
authors.forename: Hao-Jun
authors.initials: HJ
authors.lastname: Fan
authors.affiliation: 1Institute of Disaster Medicine and Public Health,Affiliated Hospital of the Logistic University of the Chinese People's Armed Police Force (PAP),Tianjin,China.
authors.forename: Shi-Ke
authors.initials: SK
authors.lastname: Hou
mesh_terms: D000256:Adenoviridae / Q000472:pathogenicity; D000257:Adenoviridae Infections / Q000097:blood / Q000235:genetics*; D000293:Adolescent; D044466:Asian People / Q000208:ethnology / Q000706:statistics & numerical data; D002681:China; D004196:Disease Outbreaks; D006801:Humans; D008297:Male; D051916:Membrane Cofactor Protein / Q000032:analysis* / Q000097:blood; D011110:Polymorphism, Genetic / Q000235:genetics* / Q000276:immunology; D055815:Young Adult
chemical_list: C497857:CD46 protein, human; D051916:Membrane Cofactor Protein
keywords: CD46; adenovirus type 55; polymorphisms