title: Acute vanishing bile duct syndrome after the use of ibuprofen.
abstract: We present a case report of a 7-year-old patient who developed toxic epidermal necrolysis (TEN) and vanishing bile duct syndrome (VBDS) after oral ibuprofen intake. Acute VBDS is a rare disease with unknown aetiology, often presenting with progressive loss of the intrahepatic biliary tract. TEN is an immune complex-mediated hypersensitivity reaction involving the skin and mucosa, which is induced by drugs or infectious diseases, sometimes leading to systemic symptoms. The patient in this case report was treated with supportive care, a steroid and ursodeoxycholic acid, with complete recovery observed by the end of the 8th month. This case report suggests that ibuprofen can cause acute vanishing duct syndrome.
authors.affiliation: Department of Paediatric Gastroenterology, Akdeniz University Faculty of Medicine, Dumlupinar Bulvari Campus, 07059 Antalya, Turkey. Electronic address: drahmetbasturk@hotmail.com.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Basturk
authors.affiliation: Department of Paediatric Gastroenterology, Akdeniz University Faculty of Medicine, Dumlupinar Bulvari Campus, 07059 Antalya, Turkey.
authors.forename: Reha
authors.initials: R
authors.lastname: Artan
authors.affiliation: Department of Paediatric Gastroenterology, Akdeniz University Faculty of Medicine, Dumlupinar Bulvari Campus, 07059 Antalya, Turkey.
authors.forename: Aygen
authors.initials: A
authors.lastname: Yılmaz
authors.affiliation: Department of Pathology, Akdeniz University Faculty of Medicine, Dumlupinar Bulvari Campus, 07059 Antalya, Turkey.
authors.forename: Mustafa T
authors.initials: MT
authors.lastname: Gelen
authors.affiliation: Department of Paediatric Neurology, Akdeniz University Faculty of Medicine, Dumlupinar Bulvari Campus, 07059 Antalya, Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Duman
mesh_terms: D058633:Antipyretics / Q000009:adverse effects*; D002648:Child; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects*; D008297:Male; D013262:Stevens-Johnson Syndrome / Q000209:etiology*; D013577:Syndrome
chemical_list: D058633:Antipyretics; D007052:Ibuprofen
keywords: Child; Ibuprofen; Vanishing bile duct syndrome