title: Altered Neural Correlates of Emotion Associated Pain Processing in Persistent Somatoform Pain Disorder: An fMRI Study.
abstract: Patients with persistent somatoform pain disorder (PSPD) suffer from long-term pain and emotional conflicts. Recently, accumulating evidence indicated that emotion has a significant role in pain perception of somatoform pain disorder. To further understand the association between emotion and pain-related brain activities, functional activities of patients with PSPD fulfilling ICD-10 criteria and healthy controls were assessed using functional magnetic resonance imaging technology, while participants viewed a series of positive, neutral, or negative pictures with or without pinprick pain stimulation. Results showed that patients with PSPD had altered brain activities in the parietal gyrus, temporal gyrus, posterior cingulate cortex, prefrontal cortex, and parahippocampus in response to pinprick pain stimuli during different emotions compared with the healthy control group. Moreover, patients with PSPD consistently showed hyperactivities in the prefrontal, the fusiform gyrus and the insula in response to negative stimuli under pinprick pain vs. non-pain condition. The current findings provide some insights into the underlying relationship between emotion and pain-related brain activity in patients with PSPD, which is of both theoretical and clinical importance.
authors.affiliation: Department of Psychiatry, Tongji Hospital of Tongji University, Shanghai, China.
authors.forename: Yanli
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics (MOE & STCSM), East China Normal University, Shanghai, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Yan
authors.affiliation: Mental Health Center of Changning District, Shanghai, China.
authors.forename: Tianming
authors.initials: T
authors.lastname: Huang
authors.affiliation: Department of Physics, East China Normal University, Shanghai, China.
authors.forename: Mingxia
authors.initials: M
authors.lastname: Fan
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Physics, East China Normal University, Shanghai, China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: Department of Psychiatry, Tongji Hospital of Tongji University, Shanghai, China.
authors.forename: Kaiji
authors.initials: K
authors.lastname: Ni
authors.affiliation: Department of Medical Imaging, Tongji Hospital of Tongji University, Shanghai, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Psychiatry, Tongji Hospital of Tongji University, Shanghai, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Lu
authors.affiliation: Department of Psychiatry, Tongji Hospital of Tongji University, Shanghai, China.
authors.forename: Wenyuan
authors.initials: W
authors.lastname: Wu
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Mingyuan
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Psychiatry, University of Massachusetts Medical School, Massachusetts, USA.
authors.forename: Xiaoduo
authors.initials: X
authors.lastname: Fan
keywords: emotion; functional magnetic resonance imaging; pain; persistent somatoform pain disorder