title: Comparable Efficacy of Abatacept Used as First-line or Second-line Biological Agent for Severe Juvenile Idiopathic Arthritis-related Uveitis.
abstract: Abatacept (ABA) has recently been proposed as second-line treatment in patients with juvenile idiopathic arthritis (JIA)-associated uveitis refractory to anti-tumor necrosis factor-α (anti-TNF) agents, but little is known about its efficacy as a first-line approach. The aim of the present study was to compare the safety and efficacy of ABA as a first-line biological agent (ABA-1) with that of ABA as a second-line treatment after 1 or more anti-TNF agents (ABA-2), in patients with severe JIA-related uveitis.
  
  
  
  In this multicenter study, we collected data on patients with severe JIA-related uveitis treated with ABA as a first-line or second-line biological agent. Changes in frequency of uveitis flares/year and ocular complications before and after ABA treatment, clinical remission, and side effects were recorded.
  
  
  
  Thirty-five patients with a mean age of 10.8 years were treated with ABA for a mean period of 19.6 months. In 4 patients, ABA administration was discontinued, owing to inefficacy on arthritis in 3 cases and allergic reaction in 1. Thirty-one patients, 14 in the ABA-1 group and 17 in the ABA-2 group, completed the 12-month followup period; of these, 17 (54.8%) had clinical remission. The mean frequency of uveitis flares decreased from 4.1 to 1.2 in the ABA-1 group (p = 0.002) and from 3.7 to 1.2 in the ABA-2 group (p = 0.004). Preexisting ocular complications improved or remained stable in all but 5 patients, all in the ABA-2 group. No significant difference was found between the efficacy of the 2 treatment modalities. ABA confirmed its good safety profile.
  
  
  
  ABA, used as first-line biological treatment or after 1 or more anti-TNF agents, induces a comparable improvement in severe refractory JIA-related uveitis.
authors.affiliation: From the Department of Pediatrics, Rheumatology Unit, University of Padua, Padua, Italy; Scientific Research Institute of Rheumatology RAMS, Moscow, Russian Federation; A. Meyer Children's Hospital, Rheumatology Unit, and Department of Internal Medicine, Section of Rheumatology, University of Florence, Florence, Italy; Department of Ophthalmology, Scientific Institute San Raffaele, Milan, Italy; Saint-Petersburg Pediatric Medical Academy, Saint-Petersburg, Russian Federation; Rheumatology Service, Cochin Hospital, Paris, France; Department of Pediatrics, Rheumatology Unit, University of Naples Federico II, Naples, Italy; Department of Pediatrics, Antonio Perrino Hospital, Brindisi, Italy; Helmgoltz Moscow Research Institute of Eye Diseases, Moscow, Russian Federation.|C. Birolo, MD, Resident in Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua; M.E. Zannin, MD, PhD, Assistant Professor of Ophthalmology, Department of Pediatrics, Rheumatology Unit, University of Padua; S. Arsenyeva, MD, PhD, Associate Professor of Ophthalmology, Scientific Research Institute of Rheumatology RAMS; R. Cimaz, MD, Professor of Pediatrics, A. Meyer Children's Hospital, Rheumatology Unit, University of Florence; E. Miserocchi, MD, PhD, Assistant Professor of Ophthalmology, Department of Ophthalmology, Scientific Institute San Raffaele; M. Dubko, MD, Associate Professor of Pediatrics, Saint-Petersburg Pediatric Medical Academy; C.J. Deslandre, MD, Associate Professor of Pediatrics, Rheumatology Service, Cochin Hospital; F. Falcini, MD, Associate Professor of Pediatrics, Department of Internal Medicine, Section of Rheumatology, University of Florence; M. Alessio, MD, Associate Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Naples Federico II; F. La Torre, MD, Assistant Professor of Pediatrics, Department of Pediatrics, Antonio Perrino Hospital; E. Denisova, MD, Assistant Professor of Ophthalmology, Helmgoltz Moscow Research Institute of Eye Diseases; G. Martini, MD, PhD, Assistant Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua; I. Nikishina, MD, Associate Professor of Pediatrics, Scientific Research Institute of Rheumatology RAMS; F. Zulian, MD, Associate Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua.
authors.forename: Carolina
authors.initials: C
authors.lastname: Birolo
authors.affiliation: From the Department of Pediatrics, Rheumatology Unit, University of Padua, Padua, Italy; Scientific Research Institute of Rheumatology RAMS, Moscow, Russian Federation; A. Meyer Children's Hospital, Rheumatology Unit, and Department of Internal Medicine, Section of Rheumatology, University of Florence, Florence, Italy; Department of Ophthalmology, Scientific Institute San Raffaele, Milan, Italy; Saint-Petersburg Pediatric Medical Academy, Saint-Petersburg, Russian Federation; Rheumatology Service, Cochin Hospital, Paris, France; Department of Pediatrics, Rheumatology Unit, University of Naples Federico II, Naples, Italy; Department of Pediatrics, Antonio Perrino Hospital, Brindisi, Italy; Helmgoltz Moscow Research Institute of Eye Diseases, Moscow, Russian Federation.|C. Birolo, MD, Resident in Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua; M.E. Zannin, MD, PhD, Assistant Professor of Ophthalmology, Department of Pediatrics, Rheumatology Unit, University of Padua; S. Arsenyeva, MD, PhD, Associate Professor of Ophthalmology, Scientific Research Institute of Rheumatology RAMS; R. Cimaz, MD, Professor of Pediatrics, A. Meyer Children's Hospital, Rheumatology Unit, University of Florence; E. Miserocchi, MD, PhD, Assistant Professor of Ophthalmology, Department of Ophthalmology, Scientific Institute San Raffaele; M. Dubko, MD, Associate Professor of Pediatrics, Saint-Petersburg Pediatric Medical Academy; C.J. Deslandre, MD, Associate Professor of Pediatrics, Rheumatology Service, Cochin Hospital; F. Falcini, MD, Associate Professor of Pediatrics, Department of Internal Medicine, Section of Rheumatology, University of Florence; M. Alessio, MD, Associate Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Naples Federico II; F. La Torre, MD, Assistant Professor of Pediatrics, Department of Pediatrics, Antonio Perrino Hospital; E. Denisova, MD, Assistant Professor of Ophthalmology, Helmgoltz Moscow Research Institute of Eye Diseases; G. Martini, MD, PhD, Assistant Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua; I. Nikishina, MD, Associate Professor of Pediatrics, Scientific Research Institute of Rheumatology RAMS; F. Zulian, MD, Associate Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua.
authors.forename: Maria Elisabetta
authors.initials: ME
authors.lastname: Zannin
authors.affiliation: From the Department of Pediatrics, Rheumatology Unit, University of Padua, Padua, Italy; Scientific Research Institute of Rheumatology RAMS, Moscow, Russian Federation; A. Meyer Children's Hospital, Rheumatology Unit, and Department of Internal Medicine, Section of Rheumatology, University of Florence, Florence, Italy; Department of Ophthalmology, Scientific Institute San Raffaele, Milan, Italy; Saint-Petersburg Pediatric Medical Academy, Saint-Petersburg, Russian Federation; Rheumatology Service, Cochin Hospital, Paris, France; Department of Pediatrics, Rheumatology Unit, University of Naples Federico II, Naples, Italy; Department of Pediatrics, Antonio Perrino Hospital, Brindisi, Italy; Helmgoltz Moscow Research Institute of Eye Diseases, Moscow, Russian Federation.|C. Birolo, MD, Resident in Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua; M.E. Zannin, MD, PhD, Assistant Professor of Ophthalmology, Department of Pediatrics, Rheumatology Unit, University of Padua; S. Arsenyeva, MD, PhD, Associate Professor of Ophthalmology, Scientific Research Institute of Rheumatology RAMS; R. Cimaz, MD, Professor of Pediatrics, A. Meyer Children's Hospital, Rheumatology Unit, University of Florence; E. Miserocchi, MD, PhD, Assistant Professor of Ophthalmology, Department of Ophthalmology, Scientific Institute San Raffaele; M. Dubko, MD, Associate Professor of Pediatrics, Saint-Petersburg Pediatric Medical Academy; C.J. Deslandre, MD, Associate Professor of Pediatrics, Rheumatology Service, Cochin Hospital; F. Falcini, MD, Associate Professor of Pediatrics, Department of Internal Medicine, Section of Rheumatology, University of Florence; M. Alessio, MD, Associate Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Naples Federico II; F. La Torre, MD, Assistant Professor of Pediatrics, Department of Pediatrics, Antonio Perrino Hospital; E. Denisova, MD, Assistant Professor of Ophthalmology, Helmgoltz Moscow Research Institute of Eye Diseases; G. Martini, MD, PhD, Assistant Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua; I. Nikishina, MD, Associate Professor of Pediatrics, Scientific Research Institute of Rheumatology RAMS; F. Zulian, MD, Associate Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Arsenyeva
authors.affiliation: From the Department of Pediatrics, Rheumatology Unit, University of Padua, Padua, Italy; Scientific Research Institute of Rheumatology RAMS, Moscow, Russian Federation; A. Meyer Children's Hospital, Rheumatology Unit, and Department of Internal Medicine, Section of Rheumatology, University of Florence, Florence, Italy; Department of Ophthalmology, Scientific Institute San Raffaele, Milan, Italy; Saint-Petersburg Pediatric Medical Academy, Saint-Petersburg, Russian Federation; Rheumatology Service, Cochin Hospital, Paris, France; Department of Pediatrics, Rheumatology Unit, University of Naples Federico II, Naples, Italy; Department of Pediatrics, Antonio Perrino Hospital, Brindisi, Italy; Helmgoltz Moscow Research Institute of Eye Diseases, Moscow, Russian Federation.|C. Birolo, MD, Resident in Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua; M.E. Zannin, MD, PhD, Assistant Professor of Ophthalmology, Department of Pediatrics, Rheumatology Unit, University of Padua; S. Arsenyeva, MD, PhD, Associate Professor of Ophthalmology, Scientific Research Institute of Rheumatology RAMS; R. Cimaz, MD, Professor of Pediatrics, A. Meyer Children's Hospital, Rheumatology Unit, University of Florence; E. Miserocchi, MD, PhD, Assistant Professor of Ophthalmology, Department of Ophthalmology, Scientific Institute San Raffaele; M. Dubko, MD, Associate Professor of Pediatrics, Saint-Petersburg Pediatric Medical Academy; C.J. Deslandre, MD, Associate Professor of Pediatrics, Rheumatology Service, Cochin Hospital; F. Falcini, MD, Associate Professor of Pediatrics, Department of Internal Medicine, Section of Rheumatology, University of Florence; M. Alessio, MD, Associate Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Naples Federico II; F. La Torre, MD, Assistant Professor of Pediatrics, Department of Pediatrics, Antonio Perrino Hospital; E. Denisova, MD, Assistant Professor of Ophthalmology, Helmgoltz Moscow Research Institute of Eye Diseases; G. Martini, MD, PhD, Assistant Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua; I. Nikishina, MD, Associate Professor of Pediatrics, Scientific Research Institute of Rheumatology RAMS; F. Zulian, MD, Associate Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua.
authors.forename: Rolando
authors.initials: R
authors.lastname: Cimaz
authors.affiliation: From the Department of Pediatrics, Rheumatology Unit, University of Padua, Padua, Italy; Scientific Research Institute of Rheumatology RAMS, Moscow, Russian Federation; A. Meyer Children's Hospital, Rheumatology Unit, and Department of Internal Medicine, Section of Rheumatology, University of Florence, Florence, Italy; Department of Ophthalmology, Scientific Institute San Raffaele, Milan, Italy; Saint-Petersburg Pediatric Medical Academy, Saint-Petersburg, Russian Federation; Rheumatology Service, Cochin Hospital, Paris, France; Department of Pediatrics, Rheumatology Unit, University of Naples Federico II, Naples, Italy; Department of Pediatrics, Antonio Perrino Hospital, Brindisi, Italy; Helmgoltz Moscow Research Institute of Eye Diseases, Moscow, Russian Federation.|C. Birolo, MD, Resident in Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua; M.E. Zannin, MD, PhD, Assistant Professor of Ophthalmology, Department of Pediatrics, Rheumatology Unit, University of Padua; S. Arsenyeva, MD, PhD, Associate Professor of Ophthalmology, Scientific Research Institute of Rheumatology RAMS; R. Cimaz, MD, Professor of Pediatrics, A. Meyer Children's Hospital, Rheumatology Unit, University of Florence; E. Miserocchi, MD, PhD, Assistant Professor of Ophthalmology, Department of Ophthalmology, Scientific Institute San Raffaele; M. Dubko, MD, Associate Professor of Pediatrics, Saint-Petersburg Pediatric Medical Academy; C.J. Deslandre, MD, Associate Professor of Pediatrics, Rheumatology Service, Cochin Hospital; F. Falcini, MD, Associate Professor of Pediatrics, Department of Internal Medicine, Section of Rheumatology, University of Florence; M. Alessio, MD, Associate Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Naples Federico II; F. La Torre, MD, Assistant Professor of Pediatrics, Department of Pediatrics, Antonio Perrino Hospital; E. Denisova, MD, Assistant Professor of Ophthalmology, Helmgoltz Moscow Research Institute of Eye Diseases; G. Martini, MD, PhD, Assistant Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua; I. Nikishina, MD, Associate Professor of Pediatrics, Scientific Research Institute of Rheumatology RAMS; F. Zulian, MD, Associate Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Miserocchi
authors.affiliation: From the Department of Pediatrics, Rheumatology Unit, University of Padua, Padua, Italy; Scientific Research Institute of Rheumatology RAMS, Moscow, Russian Federation; A. Meyer Children's Hospital, Rheumatology Unit, and Department of Internal Medicine, Section of Rheumatology, University of Florence, Florence, Italy; Department of Ophthalmology, Scientific Institute San Raffaele, Milan, Italy; Saint-Petersburg Pediatric Medical Academy, Saint-Petersburg, Russian Federation; Rheumatology Service, Cochin Hospital, Paris, France; Department of Pediatrics, Rheumatology Unit, University of Naples Federico II, Naples, Italy; Department of Pediatrics, Antonio Perrino Hospital, Brindisi, Italy; Helmgoltz Moscow Research Institute of Eye Diseases, Moscow, Russian Federation.|C. Birolo, MD, Resident in Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua; M.E. Zannin, MD, PhD, Assistant Professor of Ophthalmology, Department of Pediatrics, Rheumatology Unit, University of Padua; S. Arsenyeva, MD, PhD, Associate Professor of Ophthalmology, Scientific Research Institute of Rheumatology RAMS; R. Cimaz, MD, Professor of Pediatrics, A. Meyer Children's Hospital, Rheumatology Unit, University of Florence; E. Miserocchi, MD, PhD, Assistant Professor of Ophthalmology, Department of Ophthalmology, Scientific Institute San Raffaele; M. Dubko, MD, Associate Professor of Pediatrics, Saint-Petersburg Pediatric Medical Academy; C.J. Deslandre, MD, Associate Professor of Pediatrics, Rheumatology Service, Cochin Hospital; F. Falcini, MD, Associate Professor of Pediatrics, Department of Internal Medicine, Section of Rheumatology, University of Florence; M. Alessio, MD, Associate Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Naples Federico II; F. La Torre, MD, Assistant Professor of Pediatrics, Department of Pediatrics, Antonio Perrino Hospital; E. Denisova, MD, Assistant Professor of Ophthalmology, Helmgoltz Moscow Research Institute of Eye Diseases; G. Martini, MD, PhD, Assistant Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua; I. Nikishina, MD, Associate Professor of Pediatrics, Scientific Research Institute of Rheumatology RAMS; F. Zulian, MD, Associate Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua.
authors.forename: Margarita
authors.initials: M
authors.lastname: Dubko
authors.affiliation: From the Department of Pediatrics, Rheumatology Unit, University of Padua, Padua, Italy; Scientific Research Institute of Rheumatology RAMS, Moscow, Russian Federation; A. Meyer Children's Hospital, Rheumatology Unit, and Department of Internal Medicine, Section of Rheumatology, University of Florence, Florence, Italy; Department of Ophthalmology, Scientific Institute San Raffaele, Milan, Italy; Saint-Petersburg Pediatric Medical Academy, Saint-Petersburg, Russian Federation; Rheumatology Service, Cochin Hospital, Paris, France; Department of Pediatrics, Rheumatology Unit, University of Naples Federico II, Naples, Italy; Department of Pediatrics, Antonio Perrino Hospital, Brindisi, Italy; Helmgoltz Moscow Research Institute of Eye Diseases, Moscow, Russian Federation.|C. Birolo, MD, Resident in Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua; M.E. Zannin, MD, PhD, Assistant Professor of Ophthalmology, Department of Pediatrics, Rheumatology Unit, University of Padua; S. Arsenyeva, MD, PhD, Associate Professor of Ophthalmology, Scientific Research Institute of Rheumatology RAMS; R. Cimaz, MD, Professor of Pediatrics, A. Meyer Children's Hospital, Rheumatology Unit, University of Florence; E. Miserocchi, MD, PhD, Assistant Professor of Ophthalmology, Department of Ophthalmology, Scientific Institute San Raffaele; M. Dubko, MD, Associate Professor of Pediatrics, Saint-Petersburg Pediatric Medical Academy; C.J. Deslandre, MD, Associate Professor of Pediatrics, Rheumatology Service, Cochin Hospital; F. Falcini, MD, Associate Professor of Pediatrics, Department of Internal Medicine, Section of Rheumatology, University of Florence; M. Alessio, MD, Associate Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Naples Federico II; F. La Torre, MD, Assistant Professor of Pediatrics, Department of Pediatrics, Antonio Perrino Hospital; E. Denisova, MD, Assistant Professor of Ophthalmology, Helmgoltz Moscow Research Institute of Eye Diseases; G. Martini, MD, PhD, Assistant Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua; I. Nikishina, MD, Associate Professor of Pediatrics, Scientific Research Institute of Rheumatology RAMS; F. Zulian, MD, Associate Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua.
authors.forename: Chantal Job
authors.initials: CJ
authors.lastname: Deslandre
authors.affiliation: From the Department of Pediatrics, Rheumatology Unit, University of Padua, Padua, Italy; Scientific Research Institute of Rheumatology RAMS, Moscow, Russian Federation; A. Meyer Children's Hospital, Rheumatology Unit, and Department of Internal Medicine, Section of Rheumatology, University of Florence, Florence, Italy; Department of Ophthalmology, Scientific Institute San Raffaele, Milan, Italy; Saint-Petersburg Pediatric Medical Academy, Saint-Petersburg, Russian Federation; Rheumatology Service, Cochin Hospital, Paris, France; Department of Pediatrics, Rheumatology Unit, University of Naples Federico II, Naples, Italy; Department of Pediatrics, Antonio Perrino Hospital, Brindisi, Italy; Helmgoltz Moscow Research Institute of Eye Diseases, Moscow, Russian Federation.|C. Birolo, MD, Resident in Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua; M.E. Zannin, MD, PhD, Assistant Professor of Ophthalmology, Department of Pediatrics, Rheumatology Unit, University of Padua; S. Arsenyeva, MD, PhD, Associate Professor of Ophthalmology, Scientific Research Institute of Rheumatology RAMS; R. Cimaz, MD, Professor of Pediatrics, A. Meyer Children's Hospital, Rheumatology Unit, University of Florence; E. Miserocchi, MD, PhD, Assistant Professor of Ophthalmology, Department of Ophthalmology, Scientific Institute San Raffaele; M. Dubko, MD, Associate Professor of Pediatrics, Saint-Petersburg Pediatric Medical Academy; C.J. Deslandre, MD, Associate Professor of Pediatrics, Rheumatology Service, Cochin Hospital; F. Falcini, MD, Associate Professor of Pediatrics, Department of Internal Medicine, Section of Rheumatology, University of Florence; M. Alessio, MD, Associate Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Naples Federico II; F. La Torre, MD, Assistant Professor of Pediatrics, Department of Pediatrics, Antonio Perrino Hospital; E. Denisova, MD, Assistant Professor of Ophthalmology, Helmgoltz Moscow Research Institute of Eye Diseases; G. Martini, MD, PhD, Assistant Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua; I. Nikishina, MD, Associate Professor of Pediatrics, Scientific Research Institute of Rheumatology RAMS; F. Zulian, MD, Associate Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua.
authors.forename: Fernanda
authors.initials: F
authors.lastname: Falcini
authors.affiliation: From the Department of Pediatrics, Rheumatology Unit, University of Padua, Padua, Italy; Scientific Research Institute of Rheumatology RAMS, Moscow, Russian Federation; A. Meyer Children's Hospital, Rheumatology Unit, and Department of Internal Medicine, Section of Rheumatology, University of Florence, Florence, Italy; Department of Ophthalmology, Scientific Institute San Raffaele, Milan, Italy; Saint-Petersburg Pediatric Medical Academy, Saint-Petersburg, Russian Federation; Rheumatology Service, Cochin Hospital, Paris, France; Department of Pediatrics, Rheumatology Unit, University of Naples Federico II, Naples, Italy; Department of Pediatrics, Antonio Perrino Hospital, Brindisi, Italy; Helmgoltz Moscow Research Institute of Eye Diseases, Moscow, Russian Federation.|C. Birolo, MD, Resident in Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua; M.E. Zannin, MD, PhD, Assistant Professor of Ophthalmology, Department of Pediatrics, Rheumatology Unit, University of Padua; S. Arsenyeva, MD, PhD, Associate Professor of Ophthalmology, Scientific Research Institute of Rheumatology RAMS; R. Cimaz, MD, Professor of Pediatrics, A. Meyer Children's Hospital, Rheumatology Unit, University of Florence; E. Miserocchi, MD, PhD, Assistant Professor of Ophthalmology, Department of Ophthalmology, Scientific Institute San Raffaele; M. Dubko, MD, Associate Professor of Pediatrics, Saint-Petersburg Pediatric Medical Academy; C.J. Deslandre, MD, Associate Professor of Pediatrics, Rheumatology Service, Cochin Hospital; F. Falcini, MD, Associate Professor of Pediatrics, Department of Internal Medicine, Section of Rheumatology, University of Florence; M. Alessio, MD, Associate Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Naples Federico II; F. La Torre, MD, Assistant Professor of Pediatrics, Department of Pediatrics, Antonio Perrino Hospital; E. Denisova, MD, Assistant Professor of Ophthalmology, Helmgoltz Moscow Research Institute of Eye Diseases; G. Martini, MD, PhD, Assistant Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua; I. Nikishina, MD, Associate Professor of Pediatrics, Scientific Research Institute of Rheumatology RAMS; F. Zulian, MD, Associate Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua.
authors.forename: Maria
authors.initials: M
authors.lastname: Alessio
authors.affiliation: From the Department of Pediatrics, Rheumatology Unit, University of Padua, Padua, Italy; Scientific Research Institute of Rheumatology RAMS, Moscow, Russian Federation; A. Meyer Children's Hospital, Rheumatology Unit, and Department of Internal Medicine, Section of Rheumatology, University of Florence, Florence, Italy; Department of Ophthalmology, Scientific Institute San Raffaele, Milan, Italy; Saint-Petersburg Pediatric Medical Academy, Saint-Petersburg, Russian Federation; Rheumatology Service, Cochin Hospital, Paris, France; Department of Pediatrics, Rheumatology Unit, University of Naples Federico II, Naples, Italy; Department of Pediatrics, Antonio Perrino Hospital, Brindisi, Italy; Helmgoltz Moscow Research Institute of Eye Diseases, Moscow, Russian Federation.|C. Birolo, MD, Resident in Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua; M.E. Zannin, MD, PhD, Assistant Professor of Ophthalmology, Department of Pediatrics, Rheumatology Unit, University of Padua; S. Arsenyeva, MD, PhD, Associate Professor of Ophthalmology, Scientific Research Institute of Rheumatology RAMS; R. Cimaz, MD, Professor of Pediatrics, A. Meyer Children's Hospital, Rheumatology Unit, University of Florence; E. Miserocchi, MD, PhD, Assistant Professor of Ophthalmology, Department of Ophthalmology, Scientific Institute San Raffaele; M. Dubko, MD, Associate Professor of Pediatrics, Saint-Petersburg Pediatric Medical Academy; C.J. Deslandre, MD, Associate Professor of Pediatrics, Rheumatology Service, Cochin Hospital; F. Falcini, MD, Associate Professor of Pediatrics, Department of Internal Medicine, Section of Rheumatology, University of Florence; M. Alessio, MD, Associate Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Naples Federico II; F. La Torre, MD, Assistant Professor of Pediatrics, Department of Pediatrics, Antonio Perrino Hospital; E. Denisova, MD, Assistant Professor of Ophthalmology, Helmgoltz Moscow Research Institute of Eye Diseases; G. Martini, MD, PhD, Assistant Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua; I. Nikishina, MD, Associate Professor of Pediatrics, Scientific Research Institute of Rheumatology RAMS; F. Zulian, MD, Associate Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua.
authors.forename: Francesco
authors.initials: F
authors.lastname: La Torre
authors.affiliation: From the Department of Pediatrics, Rheumatology Unit, University of Padua, Padua, Italy; Scientific Research Institute of Rheumatology RAMS, Moscow, Russian Federation; A. Meyer Children's Hospital, Rheumatology Unit, and Department of Internal Medicine, Section of Rheumatology, University of Florence, Florence, Italy; Department of Ophthalmology, Scientific Institute San Raffaele, Milan, Italy; Saint-Petersburg Pediatric Medical Academy, Saint-Petersburg, Russian Federation; Rheumatology Service, Cochin Hospital, Paris, France; Department of Pediatrics, Rheumatology Unit, University of Naples Federico II, Naples, Italy; Department of Pediatrics, Antonio Perrino Hospital, Brindisi, Italy; Helmgoltz Moscow Research Institute of Eye Diseases, Moscow, Russian Federation.|C. Birolo, MD, Resident in Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua; M.E. Zannin, MD, PhD, Assistant Professor of Ophthalmology, Department of Pediatrics, Rheumatology Unit, University of Padua; S. Arsenyeva, MD, PhD, Associate Professor of Ophthalmology, Scientific Research Institute of Rheumatology RAMS; R. Cimaz, MD, Professor of Pediatrics, A. Meyer Children's Hospital, Rheumatology Unit, University of Florence; E. Miserocchi, MD, PhD, Assistant Professor of Ophthalmology, Department of Ophthalmology, Scientific Institute San Raffaele; M. Dubko, MD, Associate Professor of Pediatrics, Saint-Petersburg Pediatric Medical Academy; C.J. Deslandre, MD, Associate Professor of Pediatrics, Rheumatology Service, Cochin Hospital; F. Falcini, MD, Associate Professor of Pediatrics, Department of Internal Medicine, Section of Rheumatology, University of Florence; M. Alessio, MD, Associate Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Naples Federico II; F. La Torre, MD, Assistant Professor of Pediatrics, Department of Pediatrics, Antonio Perrino Hospital; E. Denisova, MD, Assistant Professor of Ophthalmology, Helmgoltz Moscow Research Institute of Eye Diseases; G. Martini, MD, PhD, Assistant Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua; I. Nikishina, MD, Associate Professor of Pediatrics, Scientific Research Institute of Rheumatology RAMS; F. Zulian, MD, Associate Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Denisova
authors.affiliation: From the Department of Pediatrics, Rheumatology Unit, University of Padua, Padua, Italy; Scientific Research Institute of Rheumatology RAMS, Moscow, Russian Federation; A. Meyer Children's Hospital, Rheumatology Unit, and Department of Internal Medicine, Section of Rheumatology, University of Florence, Florence, Italy; Department of Ophthalmology, Scientific Institute San Raffaele, Milan, Italy; Saint-Petersburg Pediatric Medical Academy, Saint-Petersburg, Russian Federation; Rheumatology Service, Cochin Hospital, Paris, France; Department of Pediatrics, Rheumatology Unit, University of Naples Federico II, Naples, Italy; Department of Pediatrics, Antonio Perrino Hospital, Brindisi, Italy; Helmgoltz Moscow Research Institute of Eye Diseases, Moscow, Russian Federation.|C. Birolo, MD, Resident in Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua; M.E. Zannin, MD, PhD, Assistant Professor of Ophthalmology, Department of Pediatrics, Rheumatology Unit, University of Padua; S. Arsenyeva, MD, PhD, Associate Professor of Ophthalmology, Scientific Research Institute of Rheumatology RAMS; R. Cimaz, MD, Professor of Pediatrics, A. Meyer Children's Hospital, Rheumatology Unit, University of Florence; E. Miserocchi, MD, PhD, Assistant Professor of Ophthalmology, Department of Ophthalmology, Scientific Institute San Raffaele; M. Dubko, MD, Associate Professor of Pediatrics, Saint-Petersburg Pediatric Medical Academy; C.J. Deslandre, MD, Associate Professor of Pediatrics, Rheumatology Service, Cochin Hospital; F. Falcini, MD, Associate Professor of Pediatrics, Department of Internal Medicine, Section of Rheumatology, University of Florence; M. Alessio, MD, Associate Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Naples Federico II; F. La Torre, MD, Assistant Professor of Pediatrics, Department of Pediatrics, Antonio Perrino Hospital; E. Denisova, MD, Assistant Professor of Ophthalmology, Helmgoltz Moscow Research Institute of Eye Diseases; G. Martini, MD, PhD, Assistant Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua; I. Nikishina, MD, Associate Professor of Pediatrics, Scientific Research Institute of Rheumatology RAMS; F. Zulian, MD, Associate Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua.
authors.forename: Giorgia
authors.initials: G
authors.lastname: Martini
authors.affiliation: From the Department of Pediatrics, Rheumatology Unit, University of Padua, Padua, Italy; Scientific Research Institute of Rheumatology RAMS, Moscow, Russian Federation; A. Meyer Children's Hospital, Rheumatology Unit, and Department of Internal Medicine, Section of Rheumatology, University of Florence, Florence, Italy; Department of Ophthalmology, Scientific Institute San Raffaele, Milan, Italy; Saint-Petersburg Pediatric Medical Academy, Saint-Petersburg, Russian Federation; Rheumatology Service, Cochin Hospital, Paris, France; Department of Pediatrics, Rheumatology Unit, University of Naples Federico II, Naples, Italy; Department of Pediatrics, Antonio Perrino Hospital, Brindisi, Italy; Helmgoltz Moscow Research Institute of Eye Diseases, Moscow, Russian Federation.|C. Birolo, MD, Resident in Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua; M.E. Zannin, MD, PhD, Assistant Professor of Ophthalmology, Department of Pediatrics, Rheumatology Unit, University of Padua; S. Arsenyeva, MD, PhD, Associate Professor of Ophthalmology, Scientific Research Institute of Rheumatology RAMS; R. Cimaz, MD, Professor of Pediatrics, A. Meyer Children's Hospital, Rheumatology Unit, University of Florence; E. Miserocchi, MD, PhD, Assistant Professor of Ophthalmology, Department of Ophthalmology, Scientific Institute San Raffaele; M. Dubko, MD, Associate Professor of Pediatrics, Saint-Petersburg Pediatric Medical Academy; C.J. Deslandre, MD, Associate Professor of Pediatrics, Rheumatology Service, Cochin Hospital; F. Falcini, MD, Associate Professor of Pediatrics, Department of Internal Medicine, Section of Rheumatology, University of Florence; M. Alessio, MD, Associate Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Naples Federico II; F. La Torre, MD, Assistant Professor of Pediatrics, Department of Pediatrics, Antonio Perrino Hospital; E. Denisova, MD, Assistant Professor of Ophthalmology, Helmgoltz Moscow Research Institute of Eye Diseases; G. Martini, MD, PhD, Assistant Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua; I. Nikishina, MD, Associate Professor of Pediatrics, Scientific Research Institute of Rheumatology RAMS; F. Zulian, MD, Associate Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua.
authors.forename: Irina
authors.initials: I
authors.lastname: Nikishina
authors.affiliation: From the Department of Pediatrics, Rheumatology Unit, University of Padua, Padua, Italy; Scientific Research Institute of Rheumatology RAMS, Moscow, Russian Federation; A. Meyer Children's Hospital, Rheumatology Unit, and Department of Internal Medicine, Section of Rheumatology, University of Florence, Florence, Italy; Department of Ophthalmology, Scientific Institute San Raffaele, Milan, Italy; Saint-Petersburg Pediatric Medical Academy, Saint-Petersburg, Russian Federation; Rheumatology Service, Cochin Hospital, Paris, France; Department of Pediatrics, Rheumatology Unit, University of Naples Federico II, Naples, Italy; Department of Pediatrics, Antonio Perrino Hospital, Brindisi, Italy; Helmgoltz Moscow Research Institute of Eye Diseases, Moscow, Russian Federation. zulian@pediatria.unipd.it.|C. Birolo, MD, Resident in Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua; M.E. Zannin, MD, PhD, Assistant Professor of Ophthalmology, Department of Pediatrics, Rheumatology Unit, University of Padua; S. Arsenyeva, MD, PhD, Associate Professor of Ophthalmology, Scientific Research Institute of Rheumatology RAMS; R. Cimaz, MD, Professor of Pediatrics, A. Meyer Children's Hospital, Rheumatology Unit, University of Florence; E. Miserocchi, MD, PhD, Assistant Professor of Ophthalmology, Department of Ophthalmology, Scientific Institute San Raffaele; M. Dubko, MD, Associate Professor of Pediatrics, Saint-Petersburg Pediatric Medical Academy; C.J. Deslandre, MD, Associate Professor of Pediatrics, Rheumatology Service, Cochin Hospital; F. Falcini, MD, Associate Professor of Pediatrics, Department of Internal Medicine, Section of Rheumatology, University of Florence; M. Alessio, MD, Associate Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Naples Federico II; F. La Torre, MD, Assistant Professor of Pediatrics, Department of Pediatrics, Antonio Perrino Hospital; E. Denisova, MD, Assistant Professor of Ophthalmology, Helmgoltz Moscow Research Institute of Eye Diseases; G. Martini, MD, PhD, Assistant Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua; I. Nikishina, MD, Associate Professor of Pediatrics, Scientific Research Institute of Rheumatology RAMS; F. Zulian, MD, Associate Professor of Pediatrics, Department of Pediatrics, Rheumatology Unit, University of Padua. zulian@pediatria.unipd.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Zulian
mesh_terms: D000069594:Abatacept / Q000627:therapeutic use*; D000293:Adolescent; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001171:Arthritis, Juvenile / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D019233:Retreatment; D016896:Treatment Outcome; D014605:Uveitis / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D018501:Antirheumatic Agents; D007166:Immunosuppressive Agents; D000069594:Abatacept
keywords: ABATACEPT; ANTI-TUMOR NECROSIS FACTOR AGENTS; JUVENILE IDIOPATHIC ARTHRITIS; UVEITIS