title: Optical coherence tomography based microangiography as a non-invasive imaging modality for early detection of choroido-neovascular membrane in choroidal rupture.
abstract: BACKGROUND
  To evaluate and identify early microvascular changes in patient with choroidal rupture using optical coherence tomography (OCT) based microangiography (OMAG).
  
  
  METHODS
  One patient (one eye) with confirmed diagnosis of choroidal rupture after sustained ocular blunt trauma underwent OMAG imaging. OMAG was performed by Zeiss spectral domain OCT-angiography prototype using a "6.5 mm × 6.5 mm" field of view around macular region. The resulting images were presented into bilayers: the retinal layer and the choroidal layer.
  
  
  RESULTS
  Choroidal rupture sites were easily shown on OMAG images with clear evidence of multiple breaks in Bruch's membrane involving macula and the region superior to nerve. OMAG provided detailed vascular network patterns in the areas of choroidal rupture, showing a concern for choroidal neovascularization (CNV). The OMAG demonstrated cross sectional area to visualize CNV location relative to the other layers of the retina, identifying functional blood vessels through the lesion. The patient's progress was followed using OMAG.
  
  
  CONCLUSIONS
  The images provided by OMAG give detailed microvascular findings about the macula and adjacent retinal region along with the underlying choroidal alternations. In our case, details of the architecture and vascular flow of CNVM in choroidal rupture was delivered by OMAG, which were used to follow the progression of the disease progression. Further studies are needed to assess the role of quantitative and qualitative OCT microangiography in the evaluation and treatment of choroidal rupture.
authors.affiliation: Department of Ophthalmology, University of Washington, 325 Ninth Avenue, Seattle, WA 98104 USA.
authors.forename: Kasra A
authors.initials: KA
authors.lastname: Rezaei
authors.affiliation: Department of Bioengineering, University of Washington, 3720 15th Ave NE, Seattle, WA 98195 USA.
authors.forename: Qinqin
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Ophthalmology, University of Washington, 325 Ninth Avenue, Seattle, WA 98104 USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Kam
authors.affiliation: Department of Bioengineering, University of Washington, 3720 15th Ave NE, Seattle, WA 98195 USA.
authors.forename: Jin
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Ophthalmology, University of Washington, 325 Ninth Avenue, Seattle, WA 98104 USA.|Department of Bioengineering, University of Washington, 3720 15th Ave NE, Seattle, WA 98195 USA.
authors.forename: Ruikang K
authors.initials: RK
authors.lastname: Wang