title: Comparative study of false memory in dementia with Lewy bodies and Alzheimer's disease.
abstract: The production of false memories (FMs) is a normal phenomenon, which can be affected in neurodegenerative diseases such as Alzheimer's disease (AD). Only few studies investigated FMs in patients with dementia with Lewy bodies (DLB). The aim of our preliminary study was to assess FMs in patients with DLB and to identify the underlying cognitive deficits influencing the production of FMs in DLB and AD. Ten AD patients and nine DLB patients performed a memory task (free recall and recognition) coupling two paradigms, namely the DRM (Deese-Roediger-McDermott) paradigm, promoting the production of FMs and the "Remember/Know" (R/K) paradigm, allowing to investigate the phenomenological experience during the recollection of a memory. A standard cognitive evaluation of memory, executive and instrumental functions completed the assessment. No FM was found in the DLB group during free recall, while the number of FMs was substantially identical in both groups during recognition. However, FMs differed from the phenomenological experience, with more K responses in DLB patients and more R responses in AD patients. None of the tests of the standard neuropsychological evaluation did correlate with measures of interest of FMs. In AD patients, the R responses associated with FMs reflect an alteration of the source memory. In DLB patients, the critical item lead to a sense of familiarity, without recollection of the circumstances in which the item was encoded, hence the K responses. This indicates a preservation of their source memory. Contrary to expectations, the type of FMs in both groups was not correlated to their cognitive profile. Hence, cognitive processes underlying the FMs appear to be different in AD and the LBD, but FMs seem independent of memory and executive abilities in these diseases.
authors.affiliation: Hôpitaux universitaires de Strasbourg, Centre mémoire de ressources et de recherche (CMRR), service de neurologie, unité de neuropsychologie, Strasbourg, France, Hôpitaux universitaires de Strasbourg, Hôpital de jour, Centre mémoire de ressources et de recherche (CMRR), Pôle de gériatrie, Strasbourg, France.
authors.forename: Clélie
authors.initials: C
authors.lastname: Phillipps
authors.affiliation: Hôpitaux universitaires de Strasbourg, Centre mémoire de ressources et de recherche (CMRR), service de neurologie, unité de neuropsychologie, Strasbourg, France, Hôpitaux universitaires de Strasbourg, Hôpital de jour, Centre mémoire de ressources et de recherche (CMRR), Pôle de gériatrie, Strasbourg, France.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Kemp
authors.affiliation: Centre hospitalier de Nancy, unité cognitivo-comportementale ; Laboratoire InterPsy, EA4432, Groupe de recherche sur les communications, Université de Lorraine, Nancy, France.
authors.forename: Christel
authors.initials: C
authors.lastname: Jacob
authors.affiliation: Hôpitaux universitaires de Strasbourg, Hôpital de jour, Centre mémoire de ressources et de recherche (CMRR), Pôle de gériatrie, Strasbourg, France.
authors.forename: Alyssa
authors.initials: A
authors.lastname: Veronneau
authors.affiliation: Hôpitaux universitaires de Strasbourg, Centre mémoire de ressources et de recherche (CMRR), service de neurologie, unité de neuropsychologie, Strasbourg, France, Hôpitaux universitaires de Strasbourg, Hôpital de jour, Centre mémoire de ressources et de recherche (CMRR), Pôle de gériatrie, Strasbourg, France.
authors.forename: Timothée
authors.initials: T
authors.lastname: Albasser
authors.affiliation: Hôpitaux universitaires de Strasbourg, Centre mémoire de ressources et de recherche (CMRR), service de neurologie, unité de neuropsychologie, Strasbourg, France, Hôpitaux universitaires de Strasbourg, Hôpital de jour, Centre mémoire de ressources et de recherche (CMRR), Pôle de gériatrie, Strasbourg, France, Université de Strasbourg et CNRS, Laboratoire ICube UMR 7357, Fédération de médecine translationnelle de Strasbourg (FMTS), Équipe IMIS/Neurocrypto, Strasbourg, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Philippi
authors.affiliation: Hôpitaux universitaires de Strasbourg, Centre mémoire de ressources et de recherche (CMRR), service de neurologie, unité de neuropsychologie, Strasbourg, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Cretin
authors.affiliation: Laboratoire de neurosciences cognitives et adaptatives - UMR 7364 CNRS/UdS, Strasbourg, France, Université de Strasbourg et CNRS, Laboratoire ICube UMR 7357, Fédération de médecine translationnelle de Strasbourg (FMTS), Équipe IMIS/Neurocrypto, Strasbourg, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Bernard
authors.affiliation: Hôpitaux universitaires de Strasbourg, Centre mémoire de ressources et de recherche (CMRR), service de neurologie, unité de neuropsychologie, Strasbourg, France, Hôpitaux universitaires de Strasbourg, Hôpital de jour, Centre mémoire de ressources et de recherche (CMRR), Pôle de gériatrie, Strasbourg, France, Université de Strasbourg et CNRS, Laboratoire ICube UMR 7357, Fédération de médecine translationnelle de Strasbourg (FMTS), Équipe IMIS/Neurocrypto, Strasbourg, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Blanc
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000523:psychology*; D003072:Cognition Disorders / Q000209:etiology / Q000523:psychology; D005260:Female; D006801:Humans; D020961:Lewy Body Disease / Q000523:psychology*; D008297:Male; D011939:Mental Recall; D008875:Middle Aged; D009483:Neuropsychological Tests; D011597:Psychomotor Performance; D012094:Repression, Psychology
keywords: Alzheimer's disease; DRM paradigm; Lewy bodies disease; false memory; source memory