title: Tackling breast cancer chemoresistance with nano-formulated siRNA.
abstract: Breast cancer is the leading cancer diagnosed in women and the second leading cause of cancer-related deaths in women. Current limitations to standard chemotherapy in the clinic are extensively researched, including problems arising from repeated treatments with the same drugs. The phenomenon that cancer cells become resistant toward certain chemo drugs is called chemotherapy resistance. In this review, we are focusing on nanoformulation of siRNA for the fight against breast cancer chemoresistance.
authors.affiliation: Department of Oncology, Wayne State University, Detroit, MI, USA.
authors.forename: S K
authors.initials: SK
authors.lastname: Jones
authors.affiliation: Department of Oncology, Wayne State University, Detroit, MI, USA.|Department of Pharmaceutical Sciences, Wayne State University, Detroit, MI, USA.|Department of Pharmacy, Pharmaceutical Technology and Biopharmacy, Ludwig-Maximilians-Universität München, München, Germany.
authors.forename: O M
authors.initials: OM
authors.lastname: Merkel
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000628:therapy*; D002986:Clinical Trials as Topic; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D044127:Epigenesis, Genetic; D005260:Female; D006801:Humans; D053758:Nanoparticles / Q000627:therapeutic use; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000235:genetics; D000067492:RNAi Therapeutics / Q000379:methods*
chemical_list: D034741:RNA, Small Interfering