title: [Hyperprolactinemia: unusual association between peripheral hypothyroidism and microprolactinoma].
abstract: We report a rare case of hyperprolactinemia revealing the association between peripheral hypothyroidism and prolactin pituitary macroadenomas. The patient was a 43-year old woman, presenting with spontaneous bilateral galactorrhea over a period of 1 year. Hyperprolactinemia was confirmed and etiologic investigation revealed peripheral hypothyroidism secondary to autoimmune thyroiditis. Therapy consisted of administration of thyroid hormone, with clinical stabilization and hormonal normalization three months later. The evolution was marked by the persistence of hyperprolactinemia and galactorrhea. The diagnosis of microprolactinoma was objectified by pituitary MRI which showed microadenoma, justifying the administration of antidopaminergic therapy Six months later, the evolution was marked by normalization of prolactin levels and disappearance of pituitary microadenoma image.
authors.affiliation: Service d'Endocrinologie Diabétologie et Maladies Métaboliques, Hopital Arrazi, CHU Mohamed VI, Faculté de Médecine et de Pharmacie, Université Cadi Ayad, Marrakech, Maroc.
authors.forename: Asmaa
authors.initials: A
authors.lastname: Chafik
authors.affiliation: Service d'Endocrinologie Diabétologie et Maladies Métaboliques, Hopital Arrazi, CHU Mohamed VI, Faculté de Médecine et de Pharmacie, Université Cadi Ayad, Marrakech, Maroc.
authors.forename: Ghizlane
authors.initials: G
authors.lastname: El Mghari
authors.affiliation: Service d'Endocrinologie Diabétologie et Maladies Métaboliques, Hopital Arrazi, CHU Mohamed VI, Faculté de Médecine et de Pharmacie, Université Cadi Ayad, Marrakech, Maroc.
authors.forename: Nawal
authors.initials: N
authors.lastname: El Ansari
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006966:Hyperprolactinemia / Q000175:diagnosis* / Q000209:etiology; D007037:Hypothyroidism / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D008279:Magnetic Resonance Imaging; D010911:Pituitary Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D015175:Prolactinoma / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D013963:Thyroid Hormones / Q000008:administration & dosage; D013967:Thyroiditis, Autoimmune / Q000150:complications / Q000175:diagnosis
chemical_list: D013963:Thyroid Hormones
keywords: Hyperprolactinemia; hypothyroidism; prolactinoma