title: The Impact of Adenomyosis on Women's Fertility.
abstract: Until recently, adenomyosis has been associated with multiparity, not impaired fertility. Currently, adenomyosis is diagnosed with increasing frequency in infertile patients since women delay their first pregnancy until their late 30s or early 40s. Although an association between adenomyosis and infertility has not been fully established, based on the available information, recent studies suggested that adenomyosis has a negative impact on female fertility. Several uncontrolled studies with limited data also suggested that treatment of adenomyosis may improve fertility. This article discusses (i) the hypothesis and epidemiology of adenomyosis, (ii) diagnostic techniques, (iii) clinical evidence of correlation between adenomyosis and infertility, (iv) proposed mechanism of infertility in women with adenomyosis, (v) different treatment strategies and reproductive outcomes, and (vi) assisted reproductive technology outcome in women with adenomyosis.
authors.affiliation: Professor.
authors.forename: Tasuku
authors.initials: T
authors.lastname: Harada
authors.affiliation: Postgraduate Student, Department of Obstetrics and Gynecology, Tottori University Faculty of Medicine, Tottori, Japan.
authors.forename: Yin Mon
authors.initials: YM
authors.lastname: Khine
authors.affiliation: Associate Professor.
authors.forename: Apostolos
authors.initials: A
authors.lastname: Kaponis
authors.affiliation: Training Doctor.
authors.forename: Theocharis
authors.initials: T
authors.lastname: Nikellis
authors.affiliation: Professor, Department of Obstetrics and Gynecology, Patras University School of Medicine, Patra, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Decavalas
authors.affiliation: Associate Professor, Department of Obstetrics and Gynecology, Tottori University, Faculty of Medicine, Tottori, Japan.
authors.forename: Fuminori
authors.initials: F
authors.lastname: Taniguchi
mesh_terms: D062788:Adenomyosis / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D003952:Diagnostic Imaging / Q000379:methods; D019468:Disease Management; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D010043:Outcome and Process Assessment, Health Care; D011247:Pregnancy; D060728:Reproductive Health; D027724:Reproductive Techniques, Assisted; D012307:Risk Factors