title: Bayesian analysis of parent-specific transmission ratio distortion in seven Spanish beef cattle breeds.
abstract: Transmission ratio distortion (TRD) is the departure from the expected Mendelian ratio in offspring, a poorly investigated biological phenomenon in livestock species. Given the current availability of specific parametric methods for the analysis of segregation data, this study focused on the screening of TRD in 602 402 single nucleotide polymorphisms covering all autosomal chromosomes in seven Spanish beef cattle breeds. On average, 0.13% (n = 786) and 0.01% (n = 29) of genetic markers evidenced sire- or dam-specific TRD respectively. There were no single nucleotide polymorphisms accounting for both sire- and dam-specific TRD at the same time, and only one marker (rs43147474) accounted for (sire-specific) TRD in all seven breeds. It must be noted that rs43147474 is located in the fourth intronic region of the GTP-binding protein 10 gene, and this locus has been previously linked to the maintenance of mitochondria and nucleolar architectures. Alternatively, other candidate genes surround this hot-spot for sire-specific TRD in the cattle genome, and they are related to embryonic and postnatal lethality as well as prostate cancer, among others. This research characterized the distribution of TRD in the bovine genome, highlighting heterogeneous results when comparing across breeds.
authors.affiliation: Grup de Recerca en Millora Genètica Molecular Veterinària, Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona, Bellaterra, 08193, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Casellas
authors.affiliation: Grup de Recerca en Remugants, Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain.
authors.forename: J J
authors.initials: JJ
authors.lastname: Cañas-Álvarez
authors.affiliation: Departamento de Anatomía, Embriología y Genética, Universidad de Zaragoza, 50013, Zaragoza, Spain.
authors.forename: A
authors.initials: A
authors.lastname: González-Rodríguez
authors.affiliation: Grup de Recerca en Millora Genètica Molecular Veterinària, Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona, Bellaterra, 08193, Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Puig-Oliveras
authors.affiliation: Grup de Recerca en Remugants, Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Fina
authors.affiliation: Grup de Recerca en Remugants, Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Piedrafita
authors.affiliation: MERAGEM, Universidad de Córdoba, 14071, Córdoba, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Molina
authors.affiliation: Departamento de Mejora Genética Animal, INIA, 28040, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Díaz
authors.affiliation: Departamento de Ciencias Agroforestales, Universidad de Valladolid, 34004, Palencia, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Baró
authors.affiliation: Departamento de Anatomía, Embriología y Genética, Universidad de Zaragoza, 50013, Zaragoza, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Varona
mesh_terms: D000483:Alleles; D000818:Animals; D001499:Bayes Theorem; D001947:Breeding; D002417:Cattle / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D040582:Inheritance Patterns; D008297:Male; D020641:Polymorphism, Single Nucleotide; D000069466:Red Meat; D013030:Spain
chemical_list: D005819:Genetic Markers
keywords: Bayes factor; GTP-binding protein; gametic competition; genome scan; meiotic drive