title: Diastereoselective Cobalt-Mediated Cross-Couplings of Cycloalkyl Iodides with Alkynyl or (Hetero)Aryl Grignard Reagents.
abstract: A highly diastereoselective cross-coupling of variously substituted cycloalkyl iodides with alkynyl and (hetero)aryl Grignard reagents using cobalt(II) chloride has been successfully developed. With the THF-soluble CoCl2·LiCl and the inexpensive ortho-phenanthroline derivative, neocuproine, as a ligand, diastereomeric ratios of up to 99:1 were achieved. A range of functional groups are tolerated in the Grignard reagent (e.g., CF3, Piv, CN, OPiv, NMe2, CO2NEt2, SF5, OTBS).
authors.affiliation: Department of Chemistry, Ludwig-Maximilians-Universität München , Butenandtstr. 5-13, Haus F, 81377 Munich, Germany.
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Hammann
authors.affiliation: Department of Chemistry, Ludwig-Maximilians-Universität München , Butenandtstr. 5-13, Haus F, 81377 Munich, Germany.
authors.forename: Diana
authors.initials: D
authors.lastname: Haas
authors.affiliation: Department of Chemistry, Ludwig-Maximilians-Universität München , Butenandtstr. 5-13, Haus F, 81377 Munich, Germany.
authors.forename: Carl-Phillip
authors.initials: CP
authors.lastname: Tüllmann
authors.affiliation: Department of Chemistry, Ludwig-Maximilians-Universität München , Butenandtstr. 5-13, Haus F, 81377 Munich, Germany.
authors.forename: Konstantin
authors.initials: K
authors.lastname: Karaghiosoff
authors.affiliation: Department of Chemistry, Ludwig-Maximilians-Universität München , Butenandtstr. 5-13, Haus F, 81377 Munich, Germany.
authors.forename: Paul
authors.initials: P
authors.lastname: Knochel