title: Health-related quality of life following treatment for extremity soft tissue sarcoma.
abstract: OBJECTIVE
  The primary objective of this study was to estimate the change in health-related quality of life (HRQL) 1 year following treatment for extremity soft tissue sarcoma (STS), measured by the EQ-5D. Secondary objectives included determining clinical variables associated with HRQL at 1 year, estimating the proportion with a clinically important difference (CID) in HRQL, and evaluating variability within EQ-5D domains.
  
  
  METHODS
  Patients over the age of 16 years, treated for a localized extremity STS, were included. The EQ-5D change score from pre-treatment to 1-year follow-up was determined. The association of clinical variables with EQ-5D scores was estimated using a linear regression model. The proportion of patients with a CID in HRQL score was determined. A vector analysis of the EQ-5D domains was undertaken.
  
  
  RESULTS
  The mean EQ-5D change score was 0.02. Age, sex, disease status, and initial EQ-5D score were associated with EQ-5D score at 1 year. There was a CID improvement in 32% and a deterioration in 24%. The anxiety and depression domain demonstrated the most change between baseline and 1 year after treatment.
  
  
  CONCLUSIONS
  Most patients maintain a high level of HRQL following treatment for extremity STS. J. Surg. Oncol. 2016;114:821-827. © 2016 2016 Wiley Periodicals, Inc.
authors.affiliation: University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Canada. djdavi@u.washington.edu.
authors.forename: Darin
authors.initials: D
authors.lastname: Davidson
authors.affiliation: Department of Pediatrics, McMaster University, Hamilton, Canada.
authors.forename: Ronald D
authors.initials: RD
authors.lastname: Barr
authors.affiliation: University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Canada.
authors.forename: Soha
authors.initials: S
authors.lastname: Riad
authors.affiliation: University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Canada.
authors.forename: Anthony M
authors.initials: AM
authors.lastname: Griffin
authors.affiliation: Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Canada.
authors.forename: Peter W
authors.initials: PW
authors.lastname: Chung
authors.affiliation: Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Canada.
authors.forename: Charles N
authors.initials: CN
authors.lastname: Catton
authors.affiliation: Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Canada.
authors.forename: Brian
authors.initials: B
authors.lastname: O'Sullivan
authors.affiliation: University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Canada.|Department of Surgical Oncology, Princess Margaret Hospital, Toronto, Canada.|Department of Surgery, University of Toronto, Toronto, Canada.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Ferguson
authors.affiliation: Division of Health Care and Outcomes Research, Toronto Western Research Institute, University Health Network and Institute of Health Policy, Management and Evaluation and Department of Physical Therapy, University of Toronto, Toronto, Canada.
authors.forename: Aileen M
authors.initials: AM
authors.lastname: Davis
authors.affiliation: University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Canada.|Department of Surgical Oncology, Princess Margaret Hospital, Toronto, Canada.|Department of Surgery, University of Toronto, Toronto, Canada.
authors.forename: Jay S
authors.initials: JS
authors.lastname: Wunder
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005121:Extremities / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006305:Health Status Indicators; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D063868:Patient Outcome Assessment; D011788:Quality of Life / Q000523:psychology; D012189:Retrospective Studies; D012509:Sarcoma / Q000175:diagnosis / Q000523:psychology / Q000601:surgery*; D055815:Young Adult
keywords: health-related quality of life; patient reported outcome; soft tissue sarcoma