title: Outcomes of Sacral Neuromodulation in Patients with Prior Surgical Treatment of Stress Urinary Incontinence and Pelvic Organ Prolapse.
abstract: The aim of this study was to evaluate the efficacy of sacral neuromodulation in patients with prior stress urinary incontinence (SUI) or pelvic organ prolapse (POP) surgery.
  
  
  
  Women in our prospective neuromodulation database were evaluated. Patients with a history of prior SUI/POP surgery were compared to those without. Medical records at baseline were reviewed, and primary outcome was defined as moderate/marked improvement on Global Response Assessment (GRA) at 3 months. Secondary outcomes were measured using bladder diaries and Overactive Bladder Symptom Severity (OABq-SS)/health-related quality of life (HRQOL). Data were analyzed with Pearson χ test, Fisher exact test, Wilcoxon rank-sum test, and repeated-measures analyses.
  
  
  
  Of 210 subjects, 108 (51%) had prior SUI/POP surgery. Patients with SUI/POP surgery had more prior hysterectomies. At 3 months, there was no difference between groups on GRA outcomes. On the bladder diary, both groups had improvement in median voids per 24 hours, urgency severity, and urge incontinence over 2 years. On the GRA, fewer patients in the SUI/POP group were treatment responders at 12 and 24 months. For urinary urgency, a few in this group were moderately/markedly improved at 6 months, and a higher proportion are reported still leaking urine at 6 and 12 months. Similar proportions in each group reported moderate/marked improvement in leaking. Satisfaction was similar between groups. The OABq-SS/HRQOL scores improved, and there was no difference between the groups.
  
  
  
  Sacral neuromodulation improves bladder symptoms in women with prior SUI/POP surgery, but response may be slightly less in those with prior surgery due to underlying bladder or pelvic floor issues.
authors.affiliation: From the *Oakland University William Beaumont School of Medicine, Rochester, MI; and †Beaumont Health, Royal Oak, MI.
authors.forename: Jamie M
authors.initials: JM
authors.lastname: Bartley
authors.forename: Verity
authors.initials: V
authors.lastname: Ramirez
authors.forename: Kim A
authors.initials: KA
authors.lastname: Killinger
authors.forename: Judith A
authors.initials: JA
authors.lastname: Boura
authors.forename: Priyanka
authors.initials: P
authors.lastname: Gupta
authors.forename: Natalie
authors.initials: N
authors.lastname: Gaines
authors.forename: Jason P
authors.initials: JP
authors.lastname: Gilleran
authors.forename: Kenneth M
authors.initials: KM
authors.lastname: Peters
mesh_terms: D000368:Aged; D004599:Electric Stimulation Therapy; D005260:Female; D006801:Humans; D008160:Lumbosacral Plexus; D008875:Middle Aged; D056887:Pelvic Organ Prolapse / Q000150:complications / Q000601:surgery*; D011446:Prospective Studies; D011788:Quality of Life; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D053201:Urinary Bladder, Overactive / Q000209:etiology / Q000628:therapy*; D014550:Urinary Incontinence, Stress / Q000150:complications / Q000601:surgery*; D053202:Urinary Incontinence, Urge / Q000209:etiology / Q000628:therapy*