title: Trials without tribulations: Minimizing the burden of pragmatic research on healthcare systems.
abstract: Pragmatic clinical trials are increasingly common because they have the potential to yield findings that are directly translatable to real-world healthcare settings. Pragmatic clinical trials need to integrate research into clinical workflow without placing an undue burden on the delivery system. This requires a research partnership between investigators and healthcare system representatives. This paper, organized as a series of case studies drawn from our experience in the NIH Health Care Systems Research Collaboratory, presents guidance from informational interviews of physician-scientists, health services researchers, and delivery system leaders who recently launched pragmatic clinical trials.
authors.affiliation: Group Health Research Institute, Seattle, WA, USA.
authors.forename: Eric B
authors.initials: EB
authors.lastname: Larson
authors.affiliation: Group Health Research Institute, Seattle, WA, USA.
authors.forename: Chris
authors.initials: C
authors.lastname: Tachibana
authors.affiliation: Group Health Research Institute, Seattle, WA, USA.
authors.forename: Ella
authors.initials: E
authors.lastname: Thompson
authors.affiliation: Kaiser Permanente Center for Health Research, Portland, OR, USA.
authors.forename: Gloria D
authors.initials: GD
authors.lastname: Coronado
authors.affiliation: Kaiser Permanente Center for Health Research, Portland, OR, USA.
authors.forename: Lynn
authors.initials: L
authors.lastname: DeBar
authors.affiliation: University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
authors.forename: Laura M
authors.initials: LM
authors.lastname: Dember
authors.affiliation: Hawaii Permanente Medical Group, Mililani, HI, USA.
authors.forename: Stacey
authors.initials: S
authors.lastname: Honda
authors.affiliation: University of California Irvine School of Medicine, Irvine CA, USA.
authors.forename: Susan S
authors.initials: SS
authors.lastname: Huang
authors.affiliation: University of Washington, Seattle, WA, USA.
authors.forename: Jeffrey G
authors.initials: JG
authors.lastname: Jarvik
authors.affiliation: OCHIN, Portland, OR USA.
authors.forename: Christine
authors.initials: C
authors.lastname: Nelson
authors.affiliation: Clinical Services Group, Hospital Corporation of America, Nashville, TN, USA.
authors.forename: Edward
authors.initials: E
authors.lastname: Septimus
authors.affiliation: Group Health Research Institute, Seattle, WA, USA.
authors.forename: Greg
authors.initials: G
authors.lastname: Simon
authors.affiliation: Group Health Research Institute, Seattle, WA, USA. Electronic address: johnson.ke@ghc.org.
authors.forename: Karin E
authors.initials: KE
authors.lastname: Johnson
mesh_terms: D003299:Cooperative Behavior; D003695:Delivery of Health Care; D006302:Health Services Research / Q000379:methods*; D006801:Humans; D064792:Pragmatic Clinical Trials as Topic / Q000191:economics* / Q000592:standards*; D012107:Research Design / Q000592:standards*; D014481:United States
keywords: Pragmatic trials