title: Peripheral and bone marrow CD34+cell levels on chronic myeloproliferative disease.
abstract: OBJECTIVE
  The aim of the present study was to examine the relationship between peripheral CD34+and bone marrow CD34+levels and the clinicopathologic characteristics and laboratory parameters of myeloproliferative disease (MPD) patients.
  
  
  METHODS
  A total of 103 MPD patients were enrolled in this study. We examined the relationship between bone marrow CD34+and peripheral CD34+levels and the patients' clinicopathologic and laboratory parameters.
  
  
  RESULTS
  There were no significant correlations between the peripheral CD34+levels and the JAK-2 V617F mutation, thrombosis, white blood cells (WBC), lactate dehydrogenase (LDH), transferrin saturation (TS), ferritin, or bone marrow cellularity. In addition, there were no significant correlations between bone marrow CD34+levels and the JAK-2 V617F mutation, thrombosis, WBC, LDH, TS, ferritin, or bone marrow cellularity (P > 0.05). We did not identify any significant relationship between peripheral CD34+and bone marrow CD34+levels (P > 0.05). However, there were significant correlations between peripheral CD34+levels and bone marrow fibrosis (P < 0.001), between bone marrow CD34+levels and constitutional symptoms (P < 0.05), and between bone marrow CD34+levels and bone marrow fibrosis (P < 0.001).
  
  
  CONCLUSIONS
  We did not find any significant relationship between the clinicopathologic and laboratory characteristics and peripheral and bone marrow CD34+cells from bone marrow fibrosis patients. There was also no significant relationship between bone marrow CD34+cells and peripheral CD34+cells. Some peripheral CD34+cells may originate from the spleen rather than the bone marrow, which may given us different result of some parameters.
authors.affiliation: a Department of Hematology , Ankara Numune Education and Research Hospital , Ankara , Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Pamukcuoglu
authors.affiliation: b Department of Hematology, Faculty of Medicine , Gazi University , Ankara , Turkey.
authors.forename: K
authors.initials: K
authors.lastname: Acar
authors.affiliation: c Department of Biostatistics, Faculty of Health Sciences , Gazi University , Ankara , Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Celik
authors.affiliation: d Department of Pathology, Faculty of Medicine , Gazi University , Ankara , Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Akyurek
authors.affiliation: b Department of Hematology, Faculty of Medicine , Gazi University , Ankara , Turkey.
authors.forename: M S
authors.initials: MS
authors.lastname: Pepeler
authors.affiliation: e Department of Hematology, Faculty of Medicine , Medical Park University , İstanbul , Turkey.
authors.forename: G T
authors.initials: GT
authors.lastname: Sucak
mesh_terms: D018952:Antigens, CD34 / Q000097:blood / Q000378:metabolism*; D002908:Chronic Disease; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009196:Myeloproliferative Disorders / Q000097:blood / Q000378:metabolism*
chemical_list: D018952:Antigens, CD34
keywords: Peripheral CD34+ cells; bone marrow CD34+ cells; bone marrow fibrosis; myeloproliferative disease