title: Two-sex mosquito model for the persistence of Wolbachia.
abstract: We develop and analyse an ordinary differential equation model to investigate the transmission dynamics of releasing Wolbachia-infected mosquitoes to establish an endemic infection in a population of wild uninfected mosquitoes. Wolbachia is a genus of endosymbiotic bacteria that can infect mosquitoes and reduce their ability to transmit some viral mosquito-transmitted diseases, including dengue fever, chikungunya, and Zika. Although the bacterium is transmitted vertically from infected mothers to their offspring, it can be difficult to establish an endemic infection in a wild mosquito population. Our transmission model for the adult and aquatic-stage mosquitoes takes into account Wolbachia-induced fitness change and cytoplasmic incompatibility. We show that, for a wide range of realistic parameter values, the basic reproduction number, [Formula: see text], is less than one. Hence, the epidemic will die out if only a few Wolbachia-infected mosquitoes are introduced into the wild population. Even though the basic reproduction number is less than one, an endemic Wolbachia infection can be established if a sufficient number of infected mosquitoes are released. This threshold effect is created by a backward bifurcation with three coexisting equilibria: a stable zero-infection equilibrium, an intermediate-infection unstable endemic equilibrium, and a high-infection stable endemic equilibrium. We analyse the impact of reducing the wild mosquito population before introducing the infected mosquitoes and observed that the most effective approach to establish the infection in the wild is based on reducing mosquitoes in both the adult and aquatic stages.
authors.affiliation: a Department of Mathematics, Center for Computational Science , Tulane University , New Orleans , LA , USA.
authors.forename: Ling
authors.initials: L
authors.lastname: Xue
authors.affiliation: a Department of Mathematics, Center for Computational Science , Tulane University , New Orleans , LA , USA.
authors.forename: Carrie A
authors.initials: CA
authors.lastname: Manore
authors.affiliation: b School of Public Health and Tropical Medicine , Tulane University , New Orleans , LA , USA.
authors.forename: Panpim
authors.initials: P
authors.lastname: Thongsripong
authors.affiliation: a Department of Mathematics, Center for Computational Science , Tulane University , New Orleans , LA , USA.
authors.forename: James M
authors.initials: JM
authors.lastname: Hyman
mesh_terms: D000330:Aedes / Q000382:microbiology*; D000818:Animals; D050936:Basic Reproduction Number; D005260:Female; D008297:Male; D008954:Models, Biological; D020577:Wolbachia / Q000502:physiology*
keywords: 92D30; 97M10; Dengue fever; Zika; backward bifurcation; basic reproduction number; chikungunya; cytoplasmic incompatibility; threshold condition; vertical transmission