title: Comparison of the safety and efficacy of single injection of subtenon triamcinolone and topical dexamethasone in reducing postoperative inflammation after phacoemulsification and intraocular lens implantation.
abstract: To compare the safety and efficacy of single injection of sub-tenon triamcinolone and topical dexamethasone in reducing post-operative inflammation after phacoemulsification and intraocular lens implantation.
  
  
  
  The randomised controlled study was conducted at Khyber Teaching Hospital, Peshawar, Pakistan, from September 2013 to February 2014. Patients who had undergone uneventful phacoemulsification with intraocular lens implantation by the same surgeon were included. Patients in Group A received 0.1% dexamethasone eye drops and those in Group B received sub-tenon triamcinolone injection (40mg/1ml). Follow-up was at 1st day, 14th day and 6 weeks post-operatively. At follow-up visit, grades of anterior chamber cells and aqueous flare were examined with slit lamp, and intraocular pressure was recorded.
  
  
  
  Of the 108 patients, each group had 54(50%) subjects. The mean age was 58.87±9.69 years (range: 33 to 84 years) in Group A and 57.77±8.93 years (range: 30 to 78 years) in Group B (p=0.544). On the first post-operative day, all the patients in both groups had some degree of inflammation in the anterior chamber. On the 14th post-operative day, anterior chamber cells were present in 4(7.4%) eyes in Group A and in 3(5.55%) eyes in Group B (p>0.999), while aqueous flare was present in 5(9.25%) eyes in Group A and 9(16.66%) eyes in Group B (p=0.391). Six weeks after the operation, no anterior chamber cells or aqueous flare was seen in any eye in either group.
  
  
  
  Sub-tenon triamcinolone injection was found to be a safe and effective alternative to topical dexamethasone for control of post-operative inflammation after phacoemulsification.
authors.affiliation: Department of Ophthalmology, Khyber Teaching Hospital Peshawar.
authors.forename: Habibullah
authors.initials: H
authors.lastname: Khan
authors.affiliation: Department of Ophthalmology , Kuwait Teaching Hospital Peshawar.
authors.forename: Mumtaz
authors.initials: M
authors.lastname: Alam
authors.affiliation: Department of Ophthalmology , Kuwait Teaching Hospital Peshawar.
authors.forename: Akbar
authors.initials: A
authors.lastname: Khan
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003907:Dexamethasone / Q000008:administration & dosage*; D005938:Glucocorticoids; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D007429:Intraocular Pressure; D019654:Lens Implantation, Intraocular; D008875:Middle Aged; D010154:Pakistan; D018918:Phacoemulsification; D011183:Postoperative Complications; D014221:Triamcinolone / Q000008:administration & dosage*; D014606:Uveitis, Anterior
chemical_list: D005938:Glucocorticoids; D014221:Triamcinolone; D003907:Dexamethasone
keywords: Dexamethasone, Intraocular inflammation, Phacoemulsification, Triamcinolone.