title: Cytomegalovirus esophagitis developing during chemoradiotherapy for esophageal cancer: two case reports.
abstract: BACKGROUND
  It is well known that cytomegalovirus esophagitis occurs in immunosuppressed patients. However, few reports have described cytomegalovirus esophagitis occurring during chemoradiotherapy for esophageal cancer.
  
  
  METHODS
  We report two cases of patients with cytomegalovirus esophagitis that developed during chemoradiotherapy for esophageal cancer. Cytomegalovirus esophagitis was diagnosed based on the presence of intranuclear inclusions in tumor biopsy specimens. The two Japanese patients presented with anorexia and fever, which improved with anti-cytomegalovirus treatment, and intranuclear inclusions were no longer seen in the specimens.
  
  
  CONCLUSIONS
  The possibility of cytomegalovirus esophagitis must be kept in mind for patients with esophageal cancer presenting with prolonged fever or digestive symptoms while receiving chemoradiotherapy.
authors.affiliation: Department of Gastroenterology, National Center of Global Health and Medicine, 1-21-1 Toyama Shinjuku-ku, Tokyo, 162-8655, Japan. k.umemoto.k@gmail.com.
authors.forename: Kumiko
authors.initials: K
authors.lastname: Umemoto
authors.affiliation: Department of Gastroenterology, National Center of Global Health and Medicine, 1-21-1 Toyama Shinjuku-ku, Tokyo, 162-8655, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kojima
authors.affiliation: Department of Gastroenterology, National Center of Global Health and Medicine, 1-21-1 Toyama Shinjuku-ku, Tokyo, 162-8655, Japan.
authors.forename: Naoyoshi
authors.initials: N
authors.lastname: Nagata
authors.affiliation: Department of Gastroenterology, National Center of Global Health and Medicine, 1-21-1 Toyama Shinjuku-ku, Tokyo, 162-8655, Japan.
authors.forename: Chizu
authors.initials: C
authors.lastname: Yokoi
authors.affiliation: Department of Gastroenterology, National Center of Global Health and Medicine, 1-21-1 Toyama Shinjuku-ku, Tokyo, 162-8655, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Sakurai
authors.affiliation: Department of Gastroenterology, National Center of Global Health and Medicine, 1-21-1 Toyama Shinjuku-ku, Tokyo, 162-8655, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Kobayakawa
authors.affiliation: Departments of Clinical Pathology, National Center of Global Health and Medicine, 1-21-1 Toyama Shinjuku-ku, 162-8655, Tokyo, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Iizuka
authors.affiliation: Departments of Clinical Pathology, National Center of Global Health and Medicine, 1-21-1 Toyama Shinjuku-ku, 162-8655, Tokyo, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Igari
authors.affiliation: Department of Gastroenterology, National Center of Global Health and Medicine, 1-21-1 Toyama Shinjuku-ku, Tokyo, 162-8655, Japan.
authors.forename: Mikio
authors.initials: M
authors.lastname: Yanase
authors.affiliation: Department of Gastroenterology, National Center of Global Health and Medicine, 1-21-1 Toyama Shinjuku-ku, Tokyo, 162-8655, Japan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Akiyama
keywords: Case report; Cytomegalovirus; Esophageal cancer; Esophagitis