title: Acetagastrodin effects on retinal oscillatory potentials in patients during the early stages of diabetes.
abstract: OBJECTIVE
  To investigate the protective effect of acetagastrodin on visual electrophysiology in patients with early-stage diabetes.
  
  
  METHODS
  A prospective, randomized, controlled, double-blind trial was conducted. Subjects who were randomly assigned to either the treatment group or the control group were orally administered acetagastrodin or placebo, respectively, for 6 months. The quantity, mean amplitude and mean latency of oscillatory potentials (OPs) wavelets at baseline and 6 months were measured on electroretinogram (ERG), in all subjects.
  
  
  RESULTS
  A total of 92 right eyes in 92 patients with type 2 diabetes, who were diagnosed for the first time, were enrolled. Each group consisted of 46 cases (46 eyes). There was no significant difference in baseline characteristic between treatment and control groups at baseline, but quantity in treatment group was more than that in control group at 6 months (P = 0.001). The mean amplitude of OPs was reduced in the control group 6 months later compared with treatment group (P = 0.001). As to mean latency of OPs, statistical difference was also detectable between the treatment group and control group 6 months later (P < 0.001). No statistical differences were found in hemoglobin between both groups at 6 months (P > 0.05).
  
  
  CONCLUSIONS
  Electrophysiological changes would go on worsening even hemoglobin was under control during the initial stage of diabetes. Acetagastrodin treatment may be an effective treatment to protect retinal neurons against such functional impairment during the early stages of diabetes.
authors.affiliation: Department of Ophthalmology, The First People's Hospital of Yunnan Province, Ocular Fundus Disease Research Center of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Second General Surgery, The First People's Hospital of Yunnan Province, Kunming, Yunnan, China. abc_45d@163.com.
authors.forename: Jianbiao
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Ophthalmology, The First People's Hospital of Yunnan Province, Ocular Fundus Disease Research Center of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Ophthalmology, The First People's Hospital of Yunnan Province, Ocular Fundus Disease Research Center of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.
authors.forename: Ninghua
authors.initials: N
authors.lastname: Ni
authors.affiliation: Department of Ophthalmology, The First People's Hospital of Yunnan Province, Ocular Fundus Disease Research Center of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China. meikm@163.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Mei
authors.affiliation: Department of Ophthalmology, The First People's Hospital of Yunnan Province, Ocular Fundus Disease Research Center of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.
authors.forename: Huo
authors.initials: H
authors.lastname: Lei
authors.affiliation: Department of Ophthalmology, Huizhou Municipal Central Hospital, Huizhou, Guangdong, China.
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, The First People's Hospital of Yunnan Province, Kunming, Yunnan, China.
authors.forename: Ben
authors.initials: B
authors.lastname: Niu
mesh_terms: D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003930:Diabetic Retinopathy / Q000503:physiopathology / Q000517:prevention & control*; D004311:Double-Blind Method; D004596:Electroretinography / Q000187:drug effects*; D005260:Female; D005960:Glucosides / Q000627:therapeutic use*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D011446:Prospective Studies; D012160:Retina / Q000503:physiopathology*; D058067:Wavelet Analysis
chemical_list: D005960:Glucosides; D006454:Hemoglobins; D018696:Neuroprotective Agents; C051420:acetagastrodine
keywords: Acetagastrodin; Diabetic retinopathy; Electrophysiology; Neuropathy; Neuroprotection