title: Endothelial glycocalyx layer shedding following lung resection.
abstract: OBJECTIVE
  We investigated if the serum biomarkers of endothelial glycocalyx layer (EGL) disruption, heparan sulfate proteoglycan (HSPG) and syndecan-1 (SDC1) were elevated following lung resection surgery.
  
  
  METHODS
  Plasma samples were collected from 16 patients undergoing lobectomy for primary lung cancer. HSPG and SDC1 were measured at five perioperative timepoints. Postoperative oxygenation was recorded.
  
  
  RESULTS
  Post-hoc pair wise comparisons showed SDC1 concentration was significantly elevated on postoperative day 2, p < 0.001. There was no relationship found between HSPG or SDC1 levels and postoperative oxygenation.
  
  
  CONCLUSIONS
  Our pilot study is the first to provide evidence of EGL disruption following lung resection surgery. We hypothesize that EGL disruption is involved in the pathogenesis of post-lung resection acute lung injury. Abstract presentation: This work was presented in a part at the Anaesthetic Research Society Spring Meeting, Royal College of Anaesthetists, London, UK, 22 April 2015.
authors.affiliation: Academic Unit of Anesthesia, Pain & Critical Care Medicine, University of Glasgow, Glasgow, UK.|Department of Anesthesia, Golden Jubilee National Hospital, Clydebank, UK.
authors.forename: Alexander
authors.initials: A
authors.lastname: Arthur
authors.affiliation: Academic Unit of Anesthesia, Pain & Critical Care Medicine, University of Glasgow, Glasgow, UK.|Department of Anesthesia, Golden Jubilee National Hospital, Clydebank, UK.
authors.forename: Phillip J
authors.initials: PJ
authors.lastname: McCall
authors.affiliation: Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, UK.
authors.forename: Lisa
authors.initials: L
authors.lastname: Jolly
authors.affiliation: Academic Unit of Anesthesia, Pain & Critical Care Medicine, University of Glasgow, Glasgow, UK.
authors.forename: John
authors.initials: J
authors.lastname: Kinsella
authors.affiliation: Department of Cardiothoracic Surgery, Golden Jubilee National Hospital, Clydebank, UK.
authors.forename: Alan
authors.initials: A
authors.lastname: Kirk
authors.affiliation: Academic Unit of Anesthesia, Pain & Critical Care Medicine, University of Glasgow, Glasgow, UK.|Department of Anesthesia, Golden Jubilee National Hospital, Clydebank, UK.
authors.forename: Ben G
authors.initials: BG
authors.lastname: Shelley
mesh_terms: D055371:Acute Lung Injury / Q000473:pathology; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001784:Blood Gas Analysis; D004730:Endothelium, Vascular / Q000378:metabolism; D005260:Female; D005541:Forced Expiratory Volume; D019276:Glycocalyx / Q000378:metabolism*; D019812:Heparan Sulfate Proteoglycans / Q000097:blood; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000032:analysis; D010865:Pilot Projects; D011184:Postoperative Period; D053668:Syndecan-1 / Q000097:blood
chemical_list: D015415:Biomarkers; D019812:Heparan Sulfate Proteoglycans; D053668:Syndecan-1; D010100:Oxygen
keywords: ARDS; acute lung injury; endothelial glycocalyx layer; heparan sulfate proteoglycan; lung resection; syndecan-1