title: Pediatric Contact Dermatitis Registry Inaugural Case Data.
abstract: BACKGROUND
  Little is known about the epidemiology of allergic contact dermatitis (ACD) in US children. More widespread diagnostic confirmation through epicutaneous patch testing is needed.
  
  
  OBJECTIVE
  The aim was to quantify patch test results from providers evaluating US children.
  
  
  METHODS
  The study is a retrospective analysis of deidentified patch test results of children aged 18 years or younger, entered by participating providers in the Pediatric Contact Dermatitis Registry, during the first year of data collection (2015-2016).
  
  
  RESULTS
  One thousand one hundred forty-two cases from 34 US states, entered by 84 providers, were analyzed. Sixty-five percent of cases had one or more positive patch test (PPT), with 48% of cases having 1 or more relevant positive patch test (RPPT). The most common PPT allergens were nickel (22%), fragrance mix I (11%), cobalt (9.1%), balsam of Peru (8.4%), neomycin (7.2%), propylene glycol (6.8%), cocamidopropyl betaine (6.4%), bacitracin (6.2%), formaldehyde (5.7%), and gold (5.7%).
  
  
  CONCLUSIONS
  This US database provides multidisciplinary information on pediatric ACD, rates of PPT, and relevant RPPT reactions, validating the high rates of pediatric ACD previously reported in the literature. The registry database is the largest comprehensive collection of US-only pediatric patch test cases on which future research can be built. Continued collaboration between patients, health care providers, manufacturers, and policy makers is needed to decrease the most common allergens in pediatric consumer products.
authors.affiliation: From the *Department of Dermatology, University of California San Diego, La Jolla; †Department of Dermatology, Indiana University Health, Indianapolis; ‡Icahn School of Medicine at Mount Sinai, New York, NY; §Department of Dermatology, University of Utah, Salt Lake City; ∥Department of Pediatrics, Eastern Maine Medical Center, Bangor; ¶College of Medicine, The University of Vermont, Burlington; #Department of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL; **Weill Medical College of Cornell University, New York, NY; ††Department of Medicine, State University of New York at Stony Brook, NY; ‡‡Allergy & Immunology Training Program, Winthrop University Hospital, Mineola, NY; §§Department of Dermatology & Cutaneous Surgery, University of Miami, Gables, FL; ∥∥Department of Dermatology and Pediatrics, Emory University School of Medicine, Atlanta, GA; ¶¶Department of Dermatology and Pediatrics, University of Connecticut School of Medicine, Farmington; ##Clinical Dermatology, Northwestern University, Chicago, IL; ***Department of Pediatrics, University of Miami Miller School of Medicine, FL; †††Children's Specialty Group, Department of Pediatrics and Dermatology, Eastern Virginia Medical School, Norfolk; ‡‡‡Department of Dermatology, Yale School of Medicine, New Haven, CT; §§§Department of Dermatology, University of Colorado Denver; ∥∥∥Denver VAMC, CO; ¶¶¶Vanguard Skin Specialists, Colorado Springs; ###Department of Dermatology, University of California San Diego; ****Department of Dermatology, Medical College of Wisconsin, Milwaukee; ††††Asthma and Allergy Care of Delaware, Newark; ‡‡‡‡Department of Dermatology, University of California San Francisco; §§§§The Everett Clinic, Dermatology Department, WA; ∥∥∥∥Physicians Skin Care, PLLC Louisville, KY, ¶¶¶¶DermResearch, PLLC, Louisville, KY and Icahn School of Medicine 
authors.forename: Alina
authors.initials: A
authors.lastname: Goldenberg
authors.forename: Nico
authors.initials: N
authors.lastname: Mousdicas
authors.forename: Nanette
authors.initials: N
authors.lastname: Silverberg
authors.forename: Douglas
authors.initials: D
authors.lastname: Powell
authors.forename: Janice L
authors.initials: JL
authors.lastname: Pelletier
authors.forename: Jonathan I
authors.initials: JI
authors.lastname: Silverberg
authors.forename: Jonathan
authors.initials: J
authors.lastname: Zippin
authors.forename: Luz
authors.initials: L
authors.lastname: Fonacier
authors.forename: Antonella
authors.initials: A
authors.lastname: Tosti
authors.forename: Leslie
authors.initials: L
authors.lastname: Lawley
authors.forename: Mary
authors.initials: M
authors.lastname: Wu Chang
authors.forename: Andrew
authors.initials: A
authors.lastname: Scheman
authors.forename: Gary
authors.initials: G
authors.lastname: Kleiner
authors.forename: Judith
authors.initials: J
authors.lastname: Williams
authors.forename: Kalman
authors.initials: K
authors.lastname: Watsky
authors.forename: Cory A
authors.initials: CA
authors.lastname: Dunnick
authors.forename: Rachel
authors.initials: R
authors.lastname: Frederickson
authors.forename: Catalina
authors.initials: C
authors.lastname: Matiz
authors.forename: Keri
authors.initials: K
authors.lastname: Chaney
authors.forename: Tracy S
authors.initials: TS
authors.lastname: Estes
authors.forename: Nina
authors.initials: N
authors.lastname: Botto
authors.forename: Michelle
authors.initials: M
authors.lastname: Draper
authors.forename: Leon
authors.initials: L
authors.lastname: Kircik
authors.forename: Aida
authors.initials: A
authors.lastname: Lugo-Somolinos
authors.forename: Brian
authors.initials: B
authors.lastname: Machler
authors.forename: Sharon E
authors.initials: SE
authors.lastname: Jacob
mesh_terms: D000293:Adolescent; D000485:Allergens / Q000009:adverse effects; D001414:Bacitracin / Q000009:adverse effects; D001453:Balsams / Q000009:adverse effects; D001622:Betaine / Q000009:adverse effects / Q000031:analogs & derivatives; D002648:Child; D002675:Child, Preschool; D003035:Cobalt / Q000009:adverse effects; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005557:Formaldehyde / Q000009:adverse effects; D006046:Gold / Q000009:adverse effects; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009355:Neomycin / Q000009:adverse effects; D009532:Nickel / Q000009:adverse effects; D010328:Patch Tests; D010476:Perfume / Q000009:adverse effects; D019946:Propylene Glycol / Q000009:adverse effects; D012042:Registries; D012189:Retrospective Studies; D014481:United States / Q000453:epidemiology
chemical_list: D000485:Allergens; D001453:Balsams; D010476:Perfume; D001414:Bacitracin; D005557:Formaldehyde; D003035:Cobalt; D001622:Betaine; C077055:cocamidopropyl betaine; D019946:Propylene Glycol; D006046:Gold; D009532:Nickel; C025080:Peruvian balsam; D009355:Neomycin