title: Update on innate immunity and perspectives on metabolite regulation in acute pancreatitis.
abstract: Acute pancreatitis is a major cause of gastrointestinal morbidity for which specific therapy is greatly needed to prevent progression to and induce resolution of severe disease.
  
  
  
  Innate immune components and metabolite signaling are recently identified as strong determinants of disease severity and resolution in acute pancreatitis and this work will be discussed herein.
  
  
  
  Targeting innate immune cell populations and metabolite signaling pathways in acute pancreatitis may result in broader and ultimately more efficacious re-direction of the inflammatory programme toward disease resolution and improved clinical outcomes.
authors.affiliation: Section of Digestive Diseases, Yale University School of Medicine, Yale University, New Haven, Connecticut, USA.
authors.forename: Rafaz
authors.initials: R
authors.lastname: Hoque
mesh_terms: D000208:Acute Disease; D000818:Animals; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D018836:Inflammation Mediators / Q000378:metabolism; D050356:Lipid Metabolism / Q000276:immunology; D058990:Molecular Targeted Therapy; D010195:Pancreatitis / Q000276:immunology* / Q000378:metabolism / Q000628:therapy; D015398:Signal Transduction / Q000276:immunology
chemical_list: D018836:Inflammation Mediators