title: Synergistic effects of longitudinal amyloid and vascular changes on lobar microbleeds.
abstract: OBJECTIVE
  To determine whether amyloid and hypertensive cerebral small vessel disease (hCSVD) changes synergistically affect the progression of lobar microbleeds in patients with subcortical vascular mild cognitive impairment (svMCI).
  
  
  METHODS
  Among 72 patients with svMCI who underwent brain MRI and [11C] Pittsburgh compound B (PiB)-PET, 52 (72.2%) completed the third year of follow-up. These patients were evaluated by annual neuropsychological testing, brain MRI, and follow-up PiB-PET.
  
  
  RESULTS
  Over 3 years, 31 of 52 patients (59.6%) had incident cerebral microbleeds (CMBs) in the lobar and deep regions. Both baseline and longitudinal changes in lacune numbers were associated with increased numbers of lobar and deep microbleeds, while baseline and longitudinal changes in PiB uptake ratio were associated only with the progression of lobar microbleeds, especially in the temporal, parietal, and occipital areas. Regional white matter hyperintensity severity was also associated with regional lobar CMBs in the parietal and occipital regions. There were interactive effects between baseline and longitudinal lacune number and PiB retention on lobar microbleed progression. Increased lobar, but not deep, CMBs were associated with decreased scores in the digit span backward task and Rey-Osterrieth Complex Figure Test.
  
  
  CONCLUSIONS
  Our findings suggest that amyloid-related pathology and hCSVD have synergistic effects on the progression of lobar microbleeds, providing new clinical insight into the interaction between amyloid burden and hCSVD on CMB progression and cognitive decline with implications for developing effective prevention strategies.
authors.affiliation: From the Department of Neurology (Y.J.K.), Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon; Departments of Neurology (H.J.K., D.L.N., S.W.S.) and Nuclear Medicine (Y.S.C., K.-H.L., S.H.M.), Sungkyunkwan University School of Medicine, and Neuroscience Center (H.J.K., D.L.N., S.W.S.), Samsung Medical Center, Seoul; Department of Neurology (J.-H.P.), Semyeong Christianity Hospital, Pohang; Biostatistics Team (S.K., S.-Y.W.), Samsung Biomedical Research Institute; Department of Biomedical Engineering (K.-C.K., J.M.L.), Hanyang University, Seoul; Department of Neurology (N.-Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan; Departments of Nuclear Medicine (J.S.K.) and Neurology (J.-H.L.), University of Ulsan College of Medicine, Asan Medical Center, Seoul; Department of Neurology (Y.J.K.), Ilsong Institute of Life Science, Hallym University, Anyang, Korea; Stroke Research Centre (D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, UK; and Departments of Health Sciences and Technology (D.L.N.) and Clinical Research Design & Evaluation (S.W.S.), SAIHST, Sungkyunkwan University, Seoul, Korea.
authors.forename: Yeo Jin
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: From the Department of Neurology (Y.J.K.), Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon; Departments of Neurology (H.J.K., D.L.N., S.W.S.) and Nuclear Medicine (Y.S.C., K.-H.L., S.H.M.), Sungkyunkwan University School of Medicine, and Neuroscience Center (H.J.K., D.L.N., S.W.S.), Samsung Medical Center, Seoul; Department of Neurology (J.-H.P.), Semyeong Christianity Hospital, Pohang; Biostatistics Team (S.K., S.-Y.W.), Samsung Biomedical Research Institute; Department of Biomedical Engineering (K.-C.K., J.M.L.), Hanyang University, Seoul; Department of Neurology (N.-Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan; Departments of Nuclear Medicine (J.S.K.) and Neurology (J.-H.L.), University of Ulsan College of Medicine, Asan Medical Center, Seoul; Department of Neurology (Y.J.K.), Ilsong Institute of Life Science, Hallym University, Anyang, Korea; Stroke Research Centre (D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, UK; and Departments of Health Sciences and Technology (D.L.N.) and Clinical Research Design & Evaluation (S.W.S.), SAIHST, Sungkyunkwan University, Seoul, Korea.
authors.forename: Hee Jin
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: From the Department of Neurology (Y.J.K.), Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon; Departments of Neurology (H.J.K., D.L.N., S.W.S.) and Nuclear Medicine (Y.S.C., K.-H.L., S.H.M.), Sungkyunkwan University School of Medicine, and Neuroscience Center (H.J.K., D.L.N., S.W.S.), Samsung Medical Center, Seoul; Department of Neurology (J.-H.P.), Semyeong Christianity Hospital, Pohang; Biostatistics Team (S.K., S.-Y.W.), Samsung Biomedical Research Institute; Department of Biomedical Engineering (K.-C.K., J.M.L.), Hanyang University, Seoul; Department of Neurology (N.-Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan; Departments of Nuclear Medicine (J.S.K.) and Neurology (J.-H.L.), University of Ulsan College of Medicine, Asan Medical Center, Seoul; Department of Neurology (Y.J.K.), Ilsong Institute of Life Science, Hallym University, Anyang, Korea; Stroke Research Centre (D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, UK; and Departments of Health Sciences and Technology (D.L.N.) and Clinical Research Design & Evaluation (S.W.S.), SAIHST, Sungkyunkwan University, Seoul, Korea.
authors.forename: Jae-Hyun
authors.initials: JH
authors.lastname: Park
authors.affiliation: From the Department of Neurology (Y.J.K.), Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon; Departments of Neurology (H.J.K., D.L.N., S.W.S.) and Nuclear Medicine (Y.S.C., K.-H.L., S.H.M.), Sungkyunkwan University School of Medicine, and Neuroscience Center (H.J.K., D.L.N., S.W.S.), Samsung Medical Center, Seoul; Department of Neurology (J.-H.P.), Semyeong Christianity Hospital, Pohang; Biostatistics Team (S.K., S.-Y.W.), Samsung Biomedical Research Institute; Department of Biomedical Engineering (K.-C.K., J.M.L.), Hanyang University, Seoul; Department of Neurology (N.-Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan; Departments of Nuclear Medicine (J.S.K.) and Neurology (J.-H.L.), University of Ulsan College of Medicine, Asan Medical Center, Seoul; Department of Neurology (Y.J.K.), Ilsong Institute of Life Science, Hallym University, Anyang, Korea; Stroke Research Centre (D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, UK; and Departments of Health Sciences and Technology (D.L.N.) and Clinical Research Design & Evaluation (S.W.S.), SAIHST, Sungkyunkwan University, Seoul, Korea.
authors.forename: Seonwoo
authors.initials: S
authors.lastname: Kim
authors.affiliation: From the Department of Neurology (Y.J.K.), Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon; Departments of Neurology (H.J.K., D.L.N., S.W.S.) and Nuclear Medicine (Y.S.C., K.-H.L., S.H.M.), Sungkyunkwan University School of Medicine, and Neuroscience Center (H.J.K., D.L.N., S.W.S.), Samsung Medical Center, Seoul; Department of Neurology (J.-H.P.), Semyeong Christianity Hospital, Pohang; Biostatistics Team (S.K., S.-Y.W.), Samsung Biomedical Research Institute; Department of Biomedical Engineering (K.-C.K., J.M.L.), Hanyang University, Seoul; Department of Neurology (N.-Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan; Departments of Nuclear Medicine (J.S.K.) and Neurology (J.-H.L.), University of Ulsan College of Medicine, Asan Medical Center, Seoul; Department of Neurology (Y.J.K.), Ilsong Institute of Life Science, Hallym University, Anyang, Korea; Stroke Research Centre (D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, UK; and Departments of Health Sciences and Technology (D.L.N.) and Clinical Research Design & Evaluation (S.W.S.), SAIHST, Sungkyunkwan University, Seoul, Korea.
authors.forename: Sook-Young
authors.initials: SY
authors.lastname: Woo
authors.affiliation: From the Department of Neurology (Y.J.K.), Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon; Departments of Neurology (H.J.K., D.L.N., S.W.S.) and Nuclear Medicine (Y.S.C., K.-H.L., S.H.M.), Sungkyunkwan University School of Medicine, and Neuroscience Center (H.J.K., D.L.N., S.W.S.), Samsung Medical Center, Seoul; Department of Neurology (J.-H.P.), Semyeong Christianity Hospital, Pohang; Biostatistics Team (S.K., S.-Y.W.), Samsung Biomedical Research Institute; Department of Biomedical Engineering (K.-C.K., J.M.L.), Hanyang University, Seoul; Department of Neurology (N.-Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan; Departments of Nuclear Medicine (J.S.K.) and Neurology (J.-H.L.), University of Ulsan College of Medicine, Asan Medical Center, Seoul; Department of Neurology (Y.J.K.), Ilsong Institute of Life Science, Hallym University, Anyang, Korea; Stroke Research Centre (D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, UK; and Departments of Health Sciences and Technology (D.L.N.) and Clinical Research Design & Evaluation (S.W.S.), SAIHST, Sungkyunkwan University, Seoul, Korea.
authors.forename: Ki-Chang
authors.initials: KC
authors.lastname: Kwak
authors.affiliation: From the Department of Neurology (Y.J.K.), Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon; Departments of Neurology (H.J.K., D.L.N., S.W.S.) and Nuclear Medicine (Y.S.C., K.-H.L., S.H.M.), Sungkyunkwan University School of Medicine, and Neuroscience Center (H.J.K., D.L.N., S.W.S.), Samsung Medical Center, Seoul; Department of Neurology (J.-H.P.), Semyeong Christianity Hospital, Pohang; Biostatistics Team (S.K., S.-Y.W.), Samsung Biomedical Research Institute; Department of Biomedical Engineering (K.-C.K., J.M.L.), Hanyang University, Seoul; Department of Neurology (N.-Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan; Departments of Nuclear Medicine (J.S.K.) and Neurology (J.-H.L.), University of Ulsan College of Medicine, Asan Medical Center, Seoul; Department of Neurology (Y.J.K.), Ilsong Institute of Life Science, Hallym University, Anyang, Korea; Stroke Research Centre (D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, UK; and Departments of Health Sciences and Technology (D.L.N.) and Clinical Research Design & Evaluation (S.W.S.), SAIHST, Sungkyunkwan University, Seoul, Korea.
authors.forename: Jong Min
authors.initials: JM
authors.lastname: Lee
authors.affiliation: From the Department of Neurology (Y.J.K.), Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon; Departments of Neurology (H.J.K., D.L.N., S.W.S.) and Nuclear Medicine (Y.S.C., K.-H.L., S.H.M.), Sungkyunkwan University School of Medicine, and Neuroscience Center (H.J.K., D.L.N., S.W.S.), Samsung Medical Center, Seoul; Department of Neurology (J.-H.P.), Semyeong Christianity Hospital, Pohang; Biostatistics Team (S.K., S.-Y.W.), Samsung Biomedical Research Institute; Department of Biomedical Engineering (K.-C.K., J.M.L.), Hanyang University, Seoul; Department of Neurology (N.-Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan; Departments of Nuclear Medicine (J.S.K.) and Neurology (J.-H.L.), University of Ulsan College of Medicine, Asan Medical Center, Seoul; Department of Neurology (Y.J.K.), Ilsong Institute of Life Science, Hallym University, Anyang, Korea; Stroke Research Centre (D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, UK; and Departments of Health Sciences and Technology (D.L.N.) and Clinical Research Design & Evaluation (S.W.S.), SAIHST, Sungkyunkwan University, Seoul, Korea.
authors.forename: Na-Yeon
authors.initials: NY
authors.lastname: Jung
authors.affiliation: From the Department of Neurology (Y.J.K.), Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon; Departments of Neurology (H.J.K., D.L.N., S.W.S.) and Nuclear Medicine (Y.S.C., K.-H.L., S.H.M.), Sungkyunkwan University School of Medicine, and Neuroscience Center (H.J.K., D.L.N., S.W.S.), Samsung Medical Center, Seoul; Department of Neurology (J.-H.P.), Semyeong Christianity Hospital, Pohang; Biostatistics Team (S.K., S.-Y.W.), Samsung Biomedical Research Institute; Department of Biomedical Engineering (K.-C.K., J.M.L.), Hanyang University, Seoul; Department of Neurology (N.-Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan; Departments of Nuclear Medicine (J.S.K.) and Neurology (J.-H.L.), University of Ulsan College of Medicine, Asan Medical Center, Seoul; Department of Neurology (Y.J.K.), Ilsong Institute of Life Science, Hallym University, Anyang, Korea; Stroke Research Centre (D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, UK; and Departments of Health Sciences and Technology (D.L.N.) and Clinical Research Design & Evaluation (S.W.S.), SAIHST, Sungkyunkwan University, Seoul, Korea.
authors.forename: Jae Seung
authors.initials: JS
authors.lastname: Kim
authors.affiliation: From the Department of Neurology (Y.J.K.), Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon; Departments of Neurology (H.J.K., D.L.N., S.W.S.) and Nuclear Medicine (Y.S.C., K.-H.L., S.H.M.), Sungkyunkwan University School of Medicine, and Neuroscience Center (H.J.K., D.L.N., S.W.S.), Samsung Medical Center, Seoul; Department of Neurology (J.-H.P.), Semyeong Christianity Hospital, Pohang; Biostatistics Team (S.K., S.-Y.W.), Samsung Biomedical Research Institute; Department of Biomedical Engineering (K.-C.K., J.M.L.), Hanyang University, Seoul; Department of Neurology (N.-Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan; Departments of Nuclear Medicine (J.S.K.) and Neurology (J.-H.L.), University of Ulsan College of Medicine, Asan Medical Center, Seoul; Department of Neurology (Y.J.K.), Ilsong Institute of Life Science, Hallym University, Anyang, Korea; Stroke Research Centre (D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, UK; and Departments of Health Sciences and Technology (D.L.N.) and Clinical Research Design & Evaluation (S.W.S.), SAIHST, Sungkyunkwan University, Seoul, Korea.
authors.forename: Yearn Seong
authors.initials: YS
authors.lastname: Choe
authors.affiliation: From the Department of Neurology (Y.J.K.), Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon; Departments of Neurology (H.J.K., D.L.N., S.W.S.) and Nuclear Medicine (Y.S.C., K.-H.L., S.H.M.), Sungkyunkwan University School of Medicine, and Neuroscience Center (H.J.K., D.L.N., S.W.S.), Samsung Medical Center, Seoul; Department of Neurology (J.-H.P.), Semyeong Christianity Hospital, Pohang; Biostatistics Team (S.K., S.-Y.W.), Samsung Biomedical Research Institute; Department of Biomedical Engineering (K.-C.K., J.M.L.), Hanyang University, Seoul; Department of Neurology (N.-Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan; Departments of Nuclear Medicine (J.S.K.) and Neurology (J.-H.L.), University of Ulsan College of Medicine, Asan Medical Center, Seoul; Department of Neurology (Y.J.K.), Ilsong Institute of Life Science, Hallym University, Anyang, Korea; Stroke Research Centre (D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, UK; and Departments of Health Sciences and Technology (D.L.N.) and Clinical Research Design & Evaluation (S.W.S.), SAIHST, Sungkyunkwan University, Seoul, Korea.
authors.forename: Kyung-Han
authors.initials: KH
authors.lastname: Lee
authors.affiliation: From the Department of Neurology (Y.J.K.), Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon; Departments of Neurology (H.J.K., D.L.N., S.W.S.) and Nuclear Medicine (Y.S.C., K.-H.L., S.H.M.), Sungkyunkwan University School of Medicine, and Neuroscience Center (H.J.K., D.L.N., S.W.S.), Samsung Medical Center, Seoul; Department of Neurology (J.-H.P.), Semyeong Christianity Hospital, Pohang; Biostatistics Team (S.K., S.-Y.W.), Samsung Biomedical Research Institute; Department of Biomedical Engineering (K.-C.K., J.M.L.), Hanyang University, Seoul; Department of Neurology (N.-Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan; Departments of Nuclear Medicine (J.S.K.) and Neurology (J.-H.L.), University of Ulsan College of Medicine, Asan Medical Center, Seoul; Department of Neurology (Y.J.K.), Ilsong Institute of Life Science, Hallym University, Anyang, Korea; Stroke Research Centre (D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, UK; and Departments of Health Sciences and Technology (D.L.N.) and Clinical Research Design & Evaluation (S.W.S.), SAIHST, Sungkyunkwan University, Seoul, Korea.
authors.forename: Seung Hwan
authors.initials: SH
authors.lastname: Moon
authors.affiliation: From the Department of Neurology (Y.J.K.), Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon; Departments of Neurology (H.J.K., D.L.N., S.W.S.) and Nuclear Medicine (Y.S.C., K.-H.L., S.H.M.), Sungkyunkwan University School of Medicine, and Neuroscience Center (H.J.K., D.L.N., S.W.S.), Samsung Medical Center, Seoul; Department of Neurology (J.-H.P.), Semyeong Christianity Hospital, Pohang; Biostatistics Team (S.K., S.-Y.W.), Samsung Biomedical Research Institute; Department of Biomedical Engineering (K.-C.K., J.M.L.), Hanyang University, Seoul; Department of Neurology (N.-Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan; Departments of Nuclear Medicine (J.S.K.) and Neurology (J.-H.L.), University of Ulsan College of Medicine, Asan Medical Center, Seoul; Department of Neurology (Y.J.K.), Ilsong Institute of Life Science, Hallym University, Anyang, Korea; Stroke Research Centre (D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, UK; and Departments of Health Sciences and Technology (D.L.N.) and Clinical Research Design & Evaluation (S.W.S.), SAIHST, Sungkyunkwan University, Seoul, Korea.
authors.forename: Jae-Hong
authors.initials: JH
authors.lastname: Lee
authors.affiliation: From the Department of Neurology (Y.J.K.), Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon; Departments of Neurology (H.J.K., D.L.N., S.W.S.) and Nuclear Medicine (Y.S.C., K.-H.L., S.H.M.), Sungkyunkwan University School of Medicine, and Neuroscience Center (H.J.K., D.L.N., S.W.S.), Samsung Medical Center, Seoul; Department of Neurology (J.-H.P.), Semyeong Christianity Hospital, Pohang; Biostatistics Team (S.K., S.-Y.W.), Samsung Biomedical Research Institute; Department of Biomedical Engineering (K.-C.K., J.M.L.), Hanyang University, Seoul; Department of Neurology (N.-Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan; Departments of Nuclear Medicine (J.S.K.) and Neurology (J.-H.L.), University of Ulsan College of Medicine, Asan Medical Center, Seoul; Department of Neurology (Y.J.K.), Ilsong Institute of Life Science, Hallym University, Anyang, Korea; Stroke Research Centre (D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, UK; and Departments of Health Sciences and Technology (D.L.N.) and Clinical Research Design & Evaluation (S.W.S.), SAIHST, Sungkyunkwan University, Seoul, Korea.
authors.forename: Yun Joong
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: From the Department of Neurology (Y.J.K.), Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon; Departments of Neurology (H.J.K., D.L.N., S.W.S.) and Nuclear Medicine (Y.S.C., K.-H.L., S.H.M.), Sungkyunkwan University School of Medicine, and Neuroscience Center (H.J.K., D.L.N., S.W.S.), Samsung Medical Center, Seoul; Department of Neurology (J.-H.P.), Semyeong Christianity Hospital, Pohang; Biostatistics Team (S.K., S.-Y.W.), Samsung Biomedical Research Institute; Department of Biomedical Engineering (K.-C.K., J.M.L.), Hanyang University, Seoul; Department of Neurology (N.-Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan; Departments of Nuclear Medicine (J.S.K.) and Neurology (J.-H.L.), University of Ulsan College of Medicine, Asan Medical Center, Seoul; Department of Neurology (Y.J.K.), Ilsong Institute of Life Science, Hallym University, Anyang, Korea; Stroke Research Centre (D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, UK; and Departments of Health Sciences and Technology (D.L.N.) and Clinical Research Design & Evaluation (S.W.S.), SAIHST, Sungkyunkwan University, Seoul, Korea.
authors.forename: David J
authors.initials: DJ
authors.lastname: Werring
authors.affiliation: From the Department of Neurology (Y.J.K.), Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon; Departments of Neurology (H.J.K., D.L.N., S.W.S.) and Nuclear Medicine (Y.S.C., K.-H.L., S.H.M.), Sungkyunkwan University School of Medicine, and Neuroscience Center (H.J.K., D.L.N., S.W.S.), Samsung Medical Center, Seoul; Department of Neurology (J.-H.P.), Semyeong Christianity Hospital, Pohang; Biostatistics Team (S.K., S.-Y.W.), Samsung Biomedical Research Institute; Department of Biomedical Engineering (K.-C.K., J.M.L.), Hanyang University, Seoul; Department of Neurology (N.-Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan; Departments of Nuclear Medicine (J.S.K.) and Neurology (J.-H.L.), University of Ulsan College of Medicine, Asan Medical Center, Seoul; Department of Neurology (Y.J.K.), Ilsong Institute of Life Science, Hallym University, Anyang, Korea; Stroke Research Centre (D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, UK; and Departments of Health Sciences and Technology (D.L.N.) and Clinical Research Design & Evaluation (S.W.S.), SAIHST, Sungkyunkwan University, Seoul, Korea.
authors.forename: Duk L
authors.initials: DL
authors.lastname: Na
authors.affiliation: From the Department of Neurology (Y.J.K.), Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon; Departments of Neurology (H.J.K., D.L.N., S.W.S.) and Nuclear Medicine (Y.S.C., K.-H.L., S.H.M.), Sungkyunkwan University School of Medicine, and Neuroscience Center (H.J.K., D.L.N., S.W.S.), Samsung Medical Center, Seoul; Department of Neurology (J.-H.P.), Semyeong Christianity Hospital, Pohang; Biostatistics Team (S.K., S.-Y.W.), Samsung Biomedical Research Institute; Department of Biomedical Engineering (K.-C.K., J.M.L.), Hanyang University, Seoul; Department of Neurology (N.-Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan; Departments of Nuclear Medicine (J.S.K.) and Neurology (J.-H.L.), University of Ulsan College of Medicine, Asan Medical Center, Seoul; Department of Neurology (Y.J.K.), Ilsong Institute of Life Science, Hallym University, Anyang, Korea; Stroke Research Centre (D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, UK; and Departments of Health Sciences and Technology (D.L.N.) and Clinical Research Design & Evaluation (S.W.S.), SAIHST, Sungkyunkwan University, Seoul, Korea. sangwonseo@empal.com.
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Seo
mesh_terms: D000368:Aged; D000686:Amyloidosis / Q000000981:diagnostic imaging* / Q000235:genetics / Q000503:physiopathology; D000814:Aniline Compounds; D001057:Apolipoproteins E / Q000235:genetics; D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging* / Q000235:genetics / Q000503:physiopathology; D059345:Cerebral Small Vessel Diseases / Q000000981:diagnostic imaging* / Q000235:genetics / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D011446:Prospective Studies; D019275:Radiopharmaceuticals; D013844:Thiazoles; D066127:White Matter / Q000000981:diagnostic imaging / Q000503:physiopathology
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000814:Aniline Compounds; D001057:Apolipoproteins E; D019275:Radiopharmaceuticals; D013844:Thiazoles