title: When membranes need an ESCRT: endosomal sorting and membrane remodelling in health and disease.
abstract: Originally discovered as regulators of cargo sorting during endosomal trafficking, ESCRT (endosomal sorting complexes required for transport) proteins are emerging as flexible machines that shape the behaviour of membranes throughout the cell. Deregulation of ESCRT activity is observed in neuro-degenerative diseases, virus infection and cancer. However, the mechanisms of pathogenesis involving ESCRTs have not yet fully come into focus. Here, we review the current knowledge of ESCRT function in health and disease and provide educated guesses for future research and focused therapeutic intervention.
authors.affiliation: IFOM-FIRC Institute of Molecular Oncology, Milan, Italy.
authors.forename: Victor
authors.initials: V
authors.lastname: Alfred
authors.affiliation: IFOM-FIRC Institute of Molecular Oncology, Milan, Italy.
authors.forename: Thomas
authors.initials: T
authors.lastname: Vaccari
mesh_terms: D000818:Animals; D056827:Endosomal Sorting Complexes Required for Transport / Q000235:genetics / Q000502:physiology / Q000627:therapeutic use; D011992:Endosomes; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000503:physiopathology / Q000628:therapy; D019636:Neurodegenerative Diseases / Q000503:physiopathology / Q000628:therapy; D009685:Nuclear Envelope; D014777:Virus Diseases / Q000503:physiopathology / Q000628:therapy
chemical_list: D056827:Endosomal Sorting Complexes Required for Transport