title: [The choice of surgery in patients with diffuse toxic goiter].
abstract: OBJECTIVE
  to define clear individual indications for different operations for diffuse toxic goiter by research of immunological markers of thyrotoxicosis recurrence probability.
  
  
  METHODS
  Long-term results of survey and treatment of 215 patients with diffuse toxic goiter are presented. Patients were divided into 2 groups. The 1st group consisted of 31 patienrs who underwent conventional partial thyroidectomy. Group 2 included 184 patients. They were divided into 2 subgroups depending on type of surgery. Subgroup A included 59 patients after partial thyroidectomy and subgroup B - 125 patients after total thyroidectomy. In group 2 surgery was defined based on only level of antibodies against TSH-receptors.
  
  
  RESULTS
  Recurrence incidence was 16 and 0% in groups 1 and 2 respectively.
  
  
  CONCLUSIONS
  In patients with diffuse toxic goiter partial thyroidectomy is possible if normal titer of antibodies against TSH-receptors is present (<1.5 U/l). Total thyroidectomy is advisable in titer ≥1.5 U/l.
authors.affiliation: Department and Clinic of Faculty Surgery, Samara State Medical University, Ministry of Health of the Russian Federation, Russia.
authors.forename: A N
authors.initials: AN
authors.lastname: Vachev
authors.affiliation: Department and Clinic of Faculty Surgery, Samara State Medical University, Ministry of Health of the Russian Federation, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Frolova
authors.affiliation: Department and Clinic of Faculty Surgery, Samara State Medical University, Ministry of Health of the Russian Federation, Russia.
authors.forename: D R
authors.initials: DR
authors.lastname: Sakhipov
authors.affiliation: Department and Clinic of Faculty Surgery, Samara State Medical University, Ministry of Health of the Russian Federation, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Morkovskikh
mesh_terms: D000328:Adult; D005260:Female; D006042:Goiter / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D018828:Immunoglobulins, Thyroid-Stimulating / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015166:Monitoring, Immunologic / Q000379:methods; D010347:Patient Care Planning; D011300:Preoperative Care / Q000379:methods; D011379:Prognosis; D011989:Receptors, Thyrotropin / Q000276:immunology*; D012008:Recurrence; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D013965:Thyroidectomy / Q000009:adverse effects / Q000379:methods; D013971:Thyrotoxicosis / Q000175:diagnosis / Q000209:etiology / Q000276:immunology / Q000503:physiopathology
chemical_list: D018828:Immunoglobulins, Thyroid-Stimulating; D011989:Receptors, Thyrotropin