title: A space network structure constructed by tetraneedlelike ZnO whiskers supporting boron nitride nanosheets to enhance comprehensive properties of poly(L-lacti acid) scaffolds.
abstract: In this study, the mechanical strength and modulus of poly(L-lacti acid) (PLLA) scaffolds were enhanced with the mechanical properties of boron nitride nanosheets (BNNSs) and tetraneedlelike ZnO whiskers (T-ZnOw). The adhesion and proliferation of cells were improved as well as osteogenic differentiation of stem cells was increased. Their dispersion statues in PLLA matrix were improved through a space network structure constructed by three-dimensional T-ZnOw supporting two-dimensional BNNSs. The results showed that the compressive strength, modulus and Vickers hardness of the scaffolds with incorporation of 1 wt% BNNSs and 7 wt% T-ZnOw together were about 96.15%, 32.86% and 357.19% higher than that of the PLLA scaffolds, respectively. This might be due to the effect of the pull out and bridging of BNNSs and T-ZnOw as well as the crack deflection, facilitating the formation of effective stress transfer between the reinforcement phases and the matrix. Furthermore, incorporation of BNNSs and T-ZnOw together into PLLA scaffolds was beneficial for attachment and viability of MG-63 cells. More importantly, the scaffolds significantly increased proliferation and promoted osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs). The enhanced mechanical and biological properties provide the potentials of PLLA/BNNSs/T-ZnOw scaffolds for the application into bone tissue engineering.
authors.affiliation: Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya School of Medicine, School of Basic Medical Science, Central South University, Changsha 410013, China.|State Key Laboratory of High Performance Complex Manufacturing, the State Key Laboratory for Powder Metallurgy, Central South University, Changsha 410083, China.|State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xi'an 710072, China.
authors.forename: Pei
authors.initials: P
authors.lastname: Feng
authors.affiliation: Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya School of Medicine, School of Basic Medical Science, Central South University, Changsha 410013, China.|School of Basic Medical Science, Central South University, Changsha 410078, China.
authors.forename: Shuping
authors.initials: S
authors.lastname: Peng
authors.affiliation: College of Chemistry, Xiangtan University, Xiangtan 411105, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wu
authors.affiliation: State Key Laboratory of High Performance Complex Manufacturing, the State Key Laboratory for Powder Metallurgy, Central South University, Changsha 410083, China.
authors.forename: Chengde
authors.initials: C
authors.lastname: Gao
authors.affiliation: State Key Laboratory of High Performance Complex Manufacturing, the State Key Laboratory for Powder Metallurgy, Central South University, Changsha 410083, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.affiliation: Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Youwen
authors.initials: Y
authors.lastname: Deng
authors.affiliation: State Key Laboratory of High Performance Complex Manufacturing, the State Key Laboratory for Powder Metallurgy, Central South University, Changsha 410083, China.
authors.forename: Cijun
authors.initials: C
authors.lastname: Shuai