title: Association between apolipoprotein B EcoRI poly﻿mor﻿phisms and coronary heart disease : A meta-analysis.
abstract: OBJECTIVE
  The study was carried out to examine the association between apolipoprotein B (ApoB) EcoRI polymorphism (E-vs. E+) (rs1042031) and coronary heart disease (CHD) risk by systematically analyzing multiple independent studies.
  
  
  METHODS
  The Hardy-Weinberg equilibrium (HWE) test was applied to assess genotype frequency distribution in healthy controls. The quality of the studies was assessed using the Newcastle-Ottawa scale (NOS). Power analysis was performed with Power and Precision V4 software. A fixed effect model was used because no deviation from homogeneity was found. Publication bias was quantified and examined with Begg's funnel plot test and Egger's linear regression method. The meta-analysis was performed by Stata 12.0 software.
  
  
  RESULTS
  A total of 21 eligible association studies were merged in this meta-analysis and the pooled sample consisted of 2994 CHD patients and 3258 healthy controls. No significant publication bias and heterogeneity were observed in these studies. The pooled odds ratio (OR) and 95% confidence interval (CI) of E-vs. E+were 1.18 (1.06-1.32). The pooled OR (95% CI) of E+E-+ E-E-vs. E+E+was 1.18 (1.04-1.34).
  
  
  CONCLUSIONS
  This meta-analysis indicated that ApoB EcoRI confers a moderate risk for CHD and the E-allele at this locus might be a susceptibility allele for the development of CHD.
authors.affiliation: Institute of Medical Systems Biology, and School of Public Health, Guangdong Medical University, No. 1 New City Avenue, Songshan Lake Science and Technology Industry Park, 523808, Dongguan, Guangdong, China.
authors.forename: Yeda
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Institute of Medical Systems Biology, and School of Public Health, Guangdong Medical University, No. 1 New City Avenue, Songshan Lake Science and Technology Industry Park, 523808, Dongguan, Guangdong, China.
authors.forename: Jingtang
authors.initials: J
authors.lastname: Zeng
authors.affiliation: Institute of Medical Systems Biology, and School of Public Health, Guangdong Medical University, No. 1 New City Avenue, Songshan Lake Science and Technology Industry Park, 523808, Dongguan, Guangdong, China.
authors.forename: Yiqing
authors.initials: Y
authors.lastname: Tan
authors.affiliation: Institute of Medical Systems Biology, and School of Public Health, Guangdong Medical University, No. 1 New City Avenue, Songshan Lake Science and Technology Industry Park, 523808, Dongguan, Guangdong, China.
authors.forename: Min
authors.initials: M
authors.lastname: Feng
authors.affiliation: Institute of Medical Systems Biology, and School of Public Health, Guangdong Medical University, No. 1 New City Avenue, Songshan Lake Science and Technology Industry Park, 523808, Dongguan, Guangdong, China.
authors.forename: Jiheng
authors.initials: J
authors.lastname: Qin
authors.affiliation: Institute of Medical Systems Biology, and School of Public Health, Guangdong Medical University, No. 1 New City Avenue, Songshan Lake Science and Technology Industry Park, 523808, Dongguan, Guangdong, China.
authors.forename: Meihua
authors.initials: M
authors.lastname: Lin
authors.affiliation: Institute of Medical Systems Biology, and School of Public Health, Guangdong Medical University, No. 1 New City Avenue, Songshan Lake Science and Technology Industry Park, 523808, Dongguan, Guangdong, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Institute of Medical Systems Biology, and School of Public Health, Guangdong Medical University, No. 1 New City Avenue, Songshan Lake Science and Technology Industry Park, 523808, Dongguan, Guangdong, China.
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Maoming People's Hospital, Maoming, Guangdong, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Maoming People's Hospital, Maoming, Guangdong, China.
authors.forename: Naizun
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Institute of Medical Systems Biology, and School of Public Health, Guangdong Medical University, No. 1 New City Avenue, Songshan Lake Science and Technology Industry Park, 523808, Dongguan, Guangdong, China. raoshaoq@gdmc.edu.cn.
authors.forename: Shaoqi
authors.initials: S
authors.lastname: Rao
mesh_terms: D001055:Apolipoproteins B / Q000235:genetics*; D003324:Coronary Artery Disease / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D012680:Sensitivity and Specificity
chemical_list: D001055:Apolipoproteins B; D005819:Genetic Markers
keywords: Apolipoprotein B; Coronary heart disease; EcoRI polymorphisms; Meta-analysis; ﻿Case-control study