title: Characteristics of mild cognitive impairment tending to convert into Alzheimer's disease or dementia with Lewy bodies: A follow-up study in a memory clinic.
abstract: OBJECTIVE
  To determine characteristics of MCI that can predict whether patients will go on to develop AD or DLB.
  
  
  METHODS
  Ninety-three patients diagnosed with MCI underwent neuropsychological and neuroimaging examinations, and were followed-up for a mean of 44.9±19.3months. They were divided into four MCI subtypes (amnestic/non-amnestic MCI, single/multiple domain) according to neuropsychological findings, and into three other MCI categories (AD-type PET, DLB-type PET, and unknown-type PET) based on (18)F-fluorodeoxyglucose PET findings. Patients who were eventually diagnosed with AD, DLB, other dementia, or remained MCI were analyzed in relation to the groups to which they had initially been allocated at the MCI stage.
  
  
  RESULTS
  Clinical diagnosis after follow-up determined AD in 21 patients (22.6%), DLB in 12 patients (12.9%), other dementia in 2 patients (2.2%), and non-converter in 58 patients (62.3%). Amnestic single-domain MCI and AD-type PET tended to convert into AD. Amnestic multiple-domain MCI and DLB-type PET tended to convert into DLB. A few patients with AD-type PET later developed DLB, and some with DLB-type PET later developed AD.
  
  
  CONCLUSIONS
  Predicting which type of dementia a person with MCI will later develop might be possible based on early assessment with clinical symptoms in conjunction with neuropsychological and (18)F-fluorodeoxyglucose PET findings.
authors.affiliation: PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, Japan; Department of Psychiatry, Yokohama City University School of Medicine, Japan.
authors.forename: Daizo
authors.initials: D
authors.lastname: Kondo
authors.affiliation: PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, Japan.
authors.forename: Kazumi
authors.initials: K
authors.lastname: Ota
authors.affiliation: PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, Japan; Department of Psychiatry, Juntendo University School of Medicine, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Kasanuki
authors.affiliation: PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, Japan.
authors.forename: Hiroshige
authors.initials: H
authors.lastname: Fujishiro
authors.affiliation: PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, Japan; Department of Psychiatry, Yokohama City University School of Medicine, Japan.
authors.forename: Yuhei
authors.initials: Y
authors.lastname: Chiba
authors.affiliation: PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Murayama
authors.affiliation: PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, Japan.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Sato
authors.affiliation: Department of Psychiatry, Yokohama City University School of Medicine, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Hirayasu
authors.affiliation: Department of Psychiatry, Juntendo University School of Medicine, Japan.
authors.forename: Heii
authors.initials: H
authors.lastname: Arai
authors.affiliation: PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, Japan; Department of Psychiatry, Juntendo University School of Medicine, Japan. Electronic address: eiseki@juntendo.ac.jp.
authors.forename: Eizo
authors.initials: E
authors.lastname: Iseki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis*; D060825:Cognitive Dysfunction / Q000473:pathology / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D005500:Follow-Up Studies; D005947:Glucose / Q000378:metabolism; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D020961:Lewy Body Disease / Q000175:diagnosis*; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D014793:Visual Cortex / Q000000981:diagnostic imaging / Q000378:metabolism
chemical_list: D019788:Fluorodeoxyglucose F18; D005947:Glucose
keywords: (18)F-fluorodeoxyglucose PET; Alzheimer's disease; Cingulate island sign; Dementia with Lewy bodies; Mild cognitive impairment; Primary visual cortex