title: An Increase Incidence in Uric Acid Nephrolithiasis: Changing Patterns.
abstract: BACKGROUND
  Nephrolithiasis is a complex disease affecting all age groups globally. As the causative factors for nephrolithiasis rises significantly, its incidence, prevalence and recurrence continues to baffle clinicians and patients.
  
  
  OBJECTIVE
  To study the prevalence of different types of renal stones extracted by Percutaneous Nephrolithotomy (PCNL) and open surgical procedures.
  
  
  METHODS
  Renal stones from 50 patients were retrieved by Percutaneous Nephrolithotomy (PCNL), Ureterorenoscopy (URS) and open surgical techniques for qualitative tests for detection of calcium, oxalate, uric acid, phosphate, ammonium ion, carbonate, cystine and xanthine.
  
  
  RESULTS
  Three patients had stone removed by open surgery and rest had undergone PCNL. Nine of the stones were pure of calcium oxalate, 9 were of pure uric acid and 32 were mixed stones. Forty one stones had calcium. Among the mixed stones, oxalate was present in 25 samples (39 of total), uric acid was seen in 17 (25 of total stones), phosphate was present in 23 (23 of total) and carbonate was present in 4 stones (4 of total). Only 1 patient had triple phosphate stone. 12 were of staghorn appearance of which 6 were of struvite type, 6 were pure uric acid and remaining were mixed oxalate-phosphate stones.
  
  
  CONCLUSIONS
  Our study, though in a small number of hospital based patients, found much higher prevalence of uric acid stones and mixed stones than reported by previous hospital based studies in north India (oxalate stones~90%, uric acid~1% and mixed stones~3%). Biochemical analysis of renal stones is warranted in all cases.
authors.affiliation: Demonstrator, Department of Biochemistry, PGIMS , Rohtak, Haryana, India .
authors.forename: Asha
authors.initials: A
authors.lastname: Kumari
authors.affiliation: Assistant Professor, Department of Biochemistry, PGIMS , Rohtak, Haryana, India .
authors.forename: Sumit
authors.initials: S
authors.lastname: Dokwal
authors.affiliation: Medical Officer, ESI Pinjore, Haryana, India .
authors.forename: Pawan
authors.initials: P
authors.lastname: Mittal
authors.affiliation: Junior Resident, Department of Biochemistry, PGIMS , Rohtak, Haryana, India .
authors.forename: Rajender
authors.initials: R
authors.lastname: Kumar
authors.affiliation: Junior Resident, Department of Biochemistry, PGIMS , Rohtak, Haryana, India .
authors.forename: Richa
authors.initials: R
authors.lastname: Goel
authors.affiliation: Assistant Professor, Department of Biochemistry, BPS GMC Khanpur, Sonepat, Haryana, India .
authors.forename: Piyush
authors.initials: P
authors.lastname: Bansal
authors.affiliation: Junior Resident, Department of Biochemistry, PGIMS , Rohtak, Haryana, India .
authors.forename: Himanshu Devender
authors.initials: HD
authors.lastname: Kumar
authors.affiliation: House Surgeon, Department of Pulmonary and Critical Care Medicine, PGIMS , Rohtak, Haryana, India .
authors.forename: Jaikrit
authors.initials: J
authors.lastname: Bhutani
keywords: Oxalate; PCNL; Paradigm shift in renal stones; Renal stones; Stone composition