title: Aerobic Exercise Modulates the Free Fatty Acids and Inflammatory Response During Obesity and Cancer Cachexia.
abstract: White adipose tissue (WAT) is no longer considered a tissue whose main function is the storage of TAG. Since the discovery of leptin in 1994, several studies have elucidated the important role of WAT as an endocrine organ, the source of the adipokines. The low-grade inflammation observed in obese and cancer cachexia patients is explained, at least partially, by the exacerbated release of proinflammatory adipokines. Despite of the recent progress in the characterization of the various adipokines and lipokines produced by WAT, little is known about the mechanisms regulating the secretion of these molecules in different physiological and pathological circumstances. Chronic exercise is a nonpharmacological therapy employed in several chronic diseases and shows an anti-inflammatory effect through the regulation of the cytokine network. In this review, we address the potential mechanisms by which the aerobic physical exercise modulate the production and release of inflammatory adipokines, as well as the inflammation-lipolysis axis in WAT, with special focus in the therapeutic role of exercise in obesity-associated insulin resistance and cancer cachexia.
authors.affiliation: Immunometabolism Research Group, Department of Cell Biology and Development - Institute of Biomedical Sciences I - University of Sao Paulo (USP), Sao Paulo, Brazil.
authors.forename: Alexandre Abilio de Souza
authors.initials: AA
authors.lastname: Teixeira
authors.affiliation: Immunometabolism Research Group, Department of Cell Biology and Development - Institute of Biomedical Sciences I - University of Sao Paulo (USP), Sao Paulo, Brazil.
authors.forename: Fábio Santos
authors.initials: FS
authors.lastname: Lira
authors.affiliation: Faculty of Nutrition - Federal University of Goias (UFG), Goiania, GO, Brazil.
authors.forename: Gustavo D
authors.initials: GD
authors.lastname: Pimentel
authors.affiliation: Immunometabolism Research Group, Department of Cell Biology and Development - Institute of Biomedical Sciences I - University of Sao Paulo (USP), Sao Paulo, Brazil.
authors.forename: Camila
authors.initials: C
authors.lastname: Oliveira de Souza
authors.affiliation: Immunometabolism Research Group, Department of Cell Biology and Development - Institute of Biomedical Sciences I - University of Sao Paulo (USP), Sao Paulo, Brazil.
authors.forename: Helena
authors.initials: H
authors.lastname: Batatinha
authors.affiliation: Immunometabolism Research Group, Department of Cell Biology and Development - Institute of Biomedical Sciences I - University of Sao Paulo (USP), Sao Paulo, Brazil.
authors.forename: Luana A
authors.initials: LA
authors.lastname: Biondo
authors.affiliation: Department of Physiology and Biophysics - Institute of Biomedical Sciences I - University of Sao Paulo (USP), Sao Paulo, Brazil.
authors.forename: Alex S
authors.initials: AS
authors.lastname: Yamashita
authors.affiliation: Immunometabolism Research Group, Department of Cell Biology and Development - Institute of Biomedical Sciences I - University of Sao Paulo (USP), Sao Paulo, Brazil.
authors.forename: Edson A Lima
authors.initials: EA
authors.lastname: Junior
authors.affiliation: Immunometabolism Research Group, Department of Cell Biology and Development - Institute of Biomedical Sciences I - University of Sao Paulo (USP), Sao Paulo, Brazil.
authors.forename: José Cesar Rosa
authors.initials: JC
authors.lastname: Neto
mesh_terms: D052436:Adipose Tissue, White / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D002100:Cachexia / Q000209:etiology / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology*; D015444:Exercise; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006801:Humans; D007249:Inflammation; D009369:Neoplasms / Q000150:complications / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology*; D009765:Obesity / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D005230:Fatty Acids, Nonesterified