title: Growth rate controls mRNA turnover in steady and non-steady states.
abstract: Gene expression has been investigated in relation with growth rate in the yeast Saccharomyces cerevisiae, following different experimental strategies. The expression of some specific gene functional categories increases or decreases with growth rate. Our recently published results have unveiled that these changes in mRNA concentration with growth depend on the relative alteration of mRNA synthesis and decay, and that, in addition to this gene-specific transcriptomic signature of growth, global mRNA turnover increases with growth rate. We discuss here these results in relation with other previous and concurrent publications, and we add new evidence which indicates that growth rate controls mRNA turnover even under non-steady-state conditions.
authors.affiliation: a Departamento de Genética and E.R.I. Biotecmed , Universitat de València , Burjassot , Spain.
authors.forename: José
authors.initials: J
authors.lastname: García-Martínez
authors.affiliation: b Departamento de Bioquımica y Biologia Molecular and E.R.I. Biotecmed, Universitat de València , Burjassot , Spain.
authors.forename: Kevin
authors.initials: K
authors.lastname: Troulé
authors.affiliation: c Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocıo-CSIC-Universidad de Sevilla, and Departamento de Genetica, Universidad de Sevilla , Seville , Spain.
authors.forename: Sebastián
authors.initials: S
authors.lastname: Chávez
authors.affiliation: b Departamento de Bioquımica y Biologia Molecular and E.R.I. Biotecmed, Universitat de València , Burjassot , Spain.
authors.forename: José E
authors.initials: JE
authors.lastname: Pérez-Ortín
mesh_terms: D015966:Gene Expression Regulation, Fungal; D020871:RNA Stability; D012331:RNA, Fungal / Q000737:chemistry / Q000378:metabolism; D012333:RNA, Messenger / Q000737:chemistry / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism
chemical_list: D012331:RNA, Fungal; D012333:RNA, Messenger
keywords: Gene expression; Saccharomyces cerevisiae; growth rate; mRNA stability; transcription; yeast