title: Effects of pomegranate juice consumption on oxidative stress in patients with type 2 diabetes: a single-blind, randomized clinical trial.
abstract: Increased free radicals production due to hyperglycemia produces oxidative stress in patients with diabetes. Pomegranate juice (PJ) has antioxidant properties. This study was conducted to determine the effects of PJ consumption in oxidative stress in type 2 diabetic patients. This study was a randomized clinical trial performed on 60, 40-65 years old diabetic patients. The patients were randomly allocated either to PJ consumption group or control. Patients in PJ group consumed 200 ml of PJ daily for six weeks. Sex distribution and the mean age were not different between two groups. After six weeks intervention, oxidized LDL and anti-oxidized LDL antibodies decreased and total serum antioxidant capacity and arylesterase activity of paraoxonase increased significantly in the PJ-treated group compared to the control group. Our data have shown that six weeks supplementation of PJ could have favorable effects on oxidative stress in patients with type 2 diabetes (T2D).
authors.affiliation: a Department of Clinical Nutrition and dietetics, Faculty of Nutrition Sciences and Food Technology , Shahid Beheshti University of Medical Sciences , Tehran , Iran.
authors.forename: Golbon
authors.initials: G
authors.lastname: Sohrab
authors.affiliation: b Cellular & Molecular Nutrition Department, Faculty of Nutrition Sciences and Food Technology , Shahid Beheshti University of Medical Sciences , Tehran , Iran.
authors.forename: Samira
authors.initials: S
authors.lastname: Ebrahimof
authors.affiliation: c Department of Community Nutrition, School of Nutritional Sciences and Dietetics , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Giti
authors.initials: G
authors.lastname: Sotoudeh
authors.affiliation: d Department of Nutrition Research, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Science and Food Technology , Shahid Beheshti University of Medical Sciences , Tehran , Iran.
authors.forename: Tirang Reza
authors.initials: TR
authors.lastname: Neyestani
authors.affiliation: b Cellular & Molecular Nutrition Department, Faculty of Nutrition Sciences and Food Technology , Shahid Beheshti University of Medical Sciences , Tehran , Iran.
authors.forename: Pooneh
authors.initials: P
authors.lastname: Angoorani
authors.affiliation: e Cellular-Molecular Research center , Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences , Tehran , Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Hedayati
authors.affiliation: c Department of Community Nutrition, School of Nutritional Sciences and Dietetics , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Fereidoun
authors.initials: F
authors.lastname: Siasi
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000032:analysis; D043303:Aryldialkylphosphatase / Q000097:blood / Q000235:genetics / Q000378:metabolism; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy*; D002149:Energy Intake; D005260:Female; D005638:Fruit / Q000737:chemistry; D000067030:Fruit and Vegetable Juices; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D029561:Lythraceae; D008297:Male; D008875:Middle Aged; D015596:Nutrition Assessment; D018384:Oxidative Stress / Q000502:physiology*; D016037:Single-Blind Method
chemical_list: D000975:Antioxidants; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human
keywords: Pomegranate juice; cardiovascular disease; diabetes; oxidative stress