title: Leucine-zipper and Sterile-α Motif Kinase (ZAK): A Potential Target for Drug Discovery.
abstract: Leucine-zipper and sterile-α motif kinase (ZAK) is a member of mixed-lineage kinase family (MLKs), which is considered as a new potential target for different physiological disorders, including myocardial hypertrophy and cardiac fibrosis, inflammation and cancer. However, the progress on its biological functions and small molecule inhibitors is limited. Only several multi-kinases inhibitors are reported to non-selectively bind with ZAK with various potencies. Herein, we provide an updated overview on the biological functions and small molecular inhibitors of ZAKs.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chang
authors.forename: Qingwen
authors.initials: Q
authors.lastname: Zhang
authors.forename: Zhengqiu
authors.initials: Z
authors.lastname: Li
authors.affiliation: School of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China. dingke@jnu.edu.cn.
authors.forename: Ke
authors.initials: K
authors.lastname: Ding
authors.affiliation: State Key Laboratory of Respiratory Diseases, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190, Kaiyuan Avenue, Science Park, Guangzhou, China. luxy2016@jnu.edu.cn.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Lu
mesh_terms: D006332:Cardiomegaly / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D055808:Drug Discovery; D006801:Humans; D016350:Leucine Zippers; D020930:MAP Kinase Kinase Kinases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D020928:Mitogen-Activated Protein Kinases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D062105:Molecular Docking Simulation; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D034622:RNA Interference; D000071682:Sterile Alpha Motif
chemical_list: D020928:Mitogen-Activated Protein Kinases; D020930:MAP Kinase Kinase Kinases