title: Twenty-Four-Hour Ambulatory Pulse Wave Analysis in Hypertension Management: Current Evidence and Perspectives.
abstract: The predictive value of vascular biomarkers such as pulse wave velocity (PWV), central arterial pressure (CAP), and augmentation index (AIx), obtained through pulse wave analysis (PWA) in resting conditions, has been documented in a variety of patient groups and populations. This allowed to make appropriate recommendations in clinical practice guidelines of several scientific societies. Due to advances in technologies, largely operator-independent methods are currently available for estimating vascular biomarkers also in ambulatory conditions, over the 24 h. According to the acceptable accuracy and reproducibility of 24-h ambulatory PWA, it appears to be a promising tool for evaluating vascular biomarkers in daily life conditions. This approach may provide an opportunity to further improve the early cardiovascular screening in subjects at risk. However, concerning the clinical use of PWA over the 24 h in ambulatory conditions at the moment, there is no sufficient evidence to support its routine clinical use. In particular, long-term outcome studies are needed to show the predictive value of 24-h PWV, CAP, and AIx values, provided by these devices, over and beyond peripheral blood pressure, and to answer the many technical and clinical questions still open. To this regard, the VASOTENS Registry, an international observational prospective study recently started, will help providing answers on a large sample of hypertensive patients recruited worldwide.
authors.affiliation: Clinical Research Unit, Italian Institute of Telemedicine, Via Colombera 29, Solbiate Arno, 21048, Varese, Italy. stefano.omboni@iitelemed.org.
authors.forename: Stefano
authors.identifier: 0000-0002-7124-2096
authors.initials: S
authors.lastname: Omboni
authors.affiliation: Hemodynamic Laboratory Ltd, Nizhniy Novgorod, Russian Federation.
authors.forename: Igor N
authors.initials: IN
authors.lastname: Posokhov
authors.affiliation: Department of Cardiology and Personified Medicine, Peoples' Friendship University of Russia, Moscow, Russian Federation.|Department of Cardiovascular Ageing, Russian Scientific and Clinical Center of Gerontology, Moscow, Russian Federation, Pirogov Russian National Research Medical University, Moscow, Russia.
authors.forename: Yulia V
authors.initials: YV
authors.lastname: Kotovskaya
authors.affiliation: Cardiovascular Prevention and Research Unit, Department of Pathophysiology, Internal Medicine and Cardiovascular Unit, "Laiko" Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Athanase D
authors.initials: AD
authors.lastname: Protogerou
authors.affiliation: Diagnosis and Therapeutic Center, Hotel-Dieu Hospital, AP-HP, Paris Descartes University, Paris, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Blacher
mesh_terms: D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods*; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D011237:Predictive Value of Tests; D063177:Pulse Wave Analysis / Q000379:methods*; D015203:Reproducibility of Results
keywords: Ambulatory monitoring; Arterial hypertension; Augmentation index; Central arterial pressure; Pulse wave analysis; Pulse wave velocity