title: Subchronic Arsenic Exposure Through Drinking Water Alters Lipid Profile and Electrolyte Status in Rats.
abstract: Arsenic is a groundwater pollutant and can cause various cardiovascular disorders in the exposed population. The aim of the present study was to assess whether subchronic arsenic exposure through drinking water can induce vascular dysfunction associated with alteration in plasma electrolytes and lipid profile. Rats were exposed to arsenic as 25, 50, and 100 ppm of sodium arsenite through drinking water for 90 consecutive days. On the 91st day, rats were sacrificed and blood was collected. Lipid profile and the levels of electrolytes (sodium, potassium, and chloride) were assessed in plasma. Arsenic reduced high-density lipoprotein cholesterol (HDL-C) and HDL-C/LDL-C ratio, but increased the levels of triglycerides, total cholesterol, low-density lipoprotein cholesterol (LDL-C), and electrolytes. The results suggest that the arsenic-mediated dyslipidemia and electrolyte retention could be important mechanisms in the arsenic-induced vascular disorder.
authors.affiliation: Department of Veterinary Pharmacology and Toxicology, Veterinary College, Vinobanagar, Shimoga, Karnataka, 577 204, India. drprashant1985@gmail.com.
authors.forename: Prashantkumar
authors.initials: P
authors.lastname: Waghe
authors.affiliation: Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, 243 122, India.
authors.forename: Souvendra Nath
authors.initials: SN
authors.lastname: Sarkar
authors.affiliation: Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, 243 122, India.
authors.forename: Thengumpallil Sasindran
authors.initials: TS
authors.lastname: Sarath
authors.affiliation: Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, 243 122, India.
authors.forename: Kannan
authors.initials: K
authors.lastname: Kandasamy
authors.affiliation: Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, 243 122, India.
authors.forename: Soumen
authors.initials: S
authors.lastname: Choudhury
authors.affiliation: Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, 243 122, India.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Gupta
authors.affiliation: Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, 243 122, India.
authors.forename: Sankarankutty
authors.initials: S
authors.lastname: Harikumar
authors.affiliation: Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, 243 122, India.
authors.forename: Santosh Kumar
authors.initials: SK
authors.lastname: Mishra
mesh_terms: D000818:Animals; D018053:Arsenites / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology*; D002712:Chlorides / Q000097:blood*; D060766:Drinking Water / Q000737:chemistry*; D004573:Electrolytes / Q000097:blood*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008055:Lipids / Q000097:blood*; D008297:Male; D011188:Potassium / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000097:blood*; D017670:Sodium Compounds / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology*
chemical_list: D018053:Arsenites; D002712:Chlorides; D060766:Drinking Water; D004573:Electrolytes; D008055:Lipids; D017670:Sodium Compounds; C017947:sodium arsenite; D012964:Sodium; D011188:Potassium
keywords: Aorta; Arsenic; Lipid profile; Rats