title: Remineralizing Effect of Topical NovaMin and Nano-hydroxyapatite on caries-like Lesions in Primary teeth.
abstract: BACKGROUND
  NovaMin is a synthetic mineral compound composed of calcium, sodium, phosphorus, and silica. It releases crystalline hydroxyl-carbonate apatite (HCA), which structurally resembles the minerals naturally found in the teeth. Nano-hydroxyapatite (NHA) is a biocompatible compound with high affinity for tooth enamel. NHA particles morphologically resemble dental enamel apatite crystals. Considering the efficacy of remineralizing agents and the importance of conservative preventive measures, this study aimed to compare the remin-eralizing effects of NovaMin and NHA on caries-like lesions in primary teeth.
  
  
  METHODS
  This in vitro experimental study was conducted on 30 sound human primary anterior teeth with no cracks or fractures. The surface microhardness (SMH) of each tooth was measured at baseline using a Vickers microhard-ness tester. The teeth were then subjected to remineralization/ demineralization cycles, and artificial caries lesions were created in them. The SMH of each tooth was measured again and the teeth were then randomly treated with toothpastes containing NovaMin or 10% NHA powder for 2 minutes daily for a period of 5 days. The SMH of each was again measured afterward. Data were statistically analyzed using independent t-tests and Mann-Whitney U tests.
  
  
  RESULTS
  The mean SMH was found to be higher in the teeth treated with NovaMin toothpaste (422.67 kgf/mm(2)) than in the teeth treated with NHA (384.2 kgf/mm(2)); However, this difference was not statistically significant.
  
  
  CONCLUSIONS
  Both NHA and NovaMin were effective for reminer-alization of caries-like lesions of primary teeth and no significant difference was detected in their efficacy.
authors.affiliation: Department of Pediatric Dentistry, Dental School, Shahed University, Tehran, Iran.
authors.forename: Roza
authors.initials: R
authors.lastname: Haghgoo
authors.affiliation: Department of Pediatric Dentistry, Dental School, Shahed University, Tehran, Iran.
authors.forename: Motahare
authors.initials: M
authors.lastname: Ahmadvand
authors.affiliation: Pedodontist Private Practice, Department of Pediatric Dentistry, Private Practice, Tehran, Iran, Phone: +02122075225, e-mail: sara_moshaverinia@yahoo.com.
authors.forename: Sareh
authors.initials: S
authors.lastname: Moshaverinia
mesh_terms: D000287:Administration, Topical; D002327:Cariostatic Agents / Q000008:administration & dosage; D003731:Dental Caries / Q000150:complications; D017886:Durapatite / Q000008:administration & dosage* / Q000032:analysis; D005898:Glass / Q000032:analysis; D006801:Humans; D066298:In Vitro Techniques; D049329:Nanostructures / Q000008:administration & dosage; D017001:Tooth Demineralization / Q000188:drug therapy* / Q000209:etiology; D014089:Tooth Remineralization / Q000379:methods*; D014094:Tooth, Deciduous; D014100:Toothpastes / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D002327:Cariostatic Agents; C510984:NovaMin; D014100:Toothpastes; D017886:Durapatite
keywords: Caries; Demineralization; Nano-hydroxyapatite; NovaMin; Remineralization; Surface microhardness.