title: A critical overview of long non-coding RNA in glioma etiology 2016: an update.
abstract: With the development of whole genome and transcriptome sequencing technologies, a growing body of long non-coding RNAs (lncRNAs) has been identified and is receiving increasing attention. LncRNAs are non-protein encoding transcripts whose functions are crucial for advancing our comprehensive understanding of biological processes in human health and diseases, specifically glioma. It has been established that lncRNAs are differently expressed in the central nervous system and may play a vital role in glioma. As of June 2016, 20 lncRNAs have been identified that may play a role in glioma pathogenesis. Investigation into the role of lncRNAs in glioma may help to identify potential biomarkers which can improve the diagnosis and treatment of glioma. In this paper, we review current understanding of the function of lncRNAs in glioma initiation and progression.
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, People's Republic of China.|Institute of Clinical Pharmacology, Central South University, Changsha, 410078, People's Republic of China.|Hunan Key Laboratory of Pharmacogenetics, Changsha, 410078, People's Republic of China.
authors.forename: Yuan-Feng
authors.initials: YF
authors.lastname: Gao
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, People's Republic of China.|Institute of Clinical Pharmacology, Central South University, Changsha, 410078, People's Republic of China.|Hunan Key Laboratory of Pharmacogenetics, Changsha, 410078, People's Republic of China.
authors.forename: Zhi-Bin
authors.initials: ZB
authors.lastname: Wang
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, People's Republic of China.|Institute of Clinical Pharmacology, Central South University, Changsha, 410078, People's Republic of China.|Hunan Key Laboratory of Pharmacogenetics, Changsha, 410078, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhu
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, People's Republic of China.|Institute of Clinical Pharmacology, Central South University, Changsha, 410078, People's Republic of China.|Hunan Key Laboratory of Pharmacogenetics, Changsha, 410078, People's Republic of China.
authors.forename: Chen-Xue
authors.initials: CX
authors.lastname: Mao
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, People's Republic of China.|Institute of Clinical Pharmacology, Central South University, Changsha, 410078, People's Republic of China.|Hunan Key Laboratory of Pharmacogenetics, Changsha, 410078, People's Republic of China.
authors.forename: Xiao-Yuan
authors.initials: XY
authors.lastname: Mao
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, People's Republic of China.|Institute of Clinical Pharmacology, Central South University, Changsha, 410078, People's Republic of China.|Hunan Key Laboratory of Pharmacogenetics, Changsha, 410078, People's Republic of China.
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, People's Republic of China.|Institute of Clinical Pharmacology, Central South University, Changsha, 410078, People's Republic of China.|Hunan Key Laboratory of Pharmacogenetics, Changsha, 410078, People's Republic of China.
authors.forename: Ji-Ye
authors.initials: JY
authors.lastname: Yin
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, People's Republic of China.|Institute of Clinical Pharmacology, Central South University, Changsha, 410078, People's Republic of China.|Hunan Key Laboratory of Pharmacogenetics, Changsha, 410078, People's Republic of China.
authors.forename: Hong-Hao
authors.initials: HH
authors.lastname: Zhou
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, People's Republic of China. liuzhaoqian63@126.com.|Institute of Clinical Pharmacology, Central South University, Changsha, 410078, People's Republic of China. liuzhaoqian63@126.com.|Hunan Key Laboratory of Pharmacogenetics, Changsha, 410078, People's Republic of China. liuzhaoqian63@126.com.
authors.forename: Zhao-Qian
authors.identifier: http://orcid.org/0000-0003-0428-3928
authors.initials: ZQ
authors.lastname: Liu
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D002490:Central Nervous System / Q000473:pathology*; D018450:Disease Progression; D005910:Glioma / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D062085:RNA, Long Noncoding
keywords: Functional roles; Glioma; Potential biomarkers and therapeutic targets; lncRNAs