title: Bevacizumab for Ovarian Cancer at High Risk of Progression: Reproducibility of Trial Results in 'Real-world' Patients.
abstract: Bevacizumab has become a 'community standard' at many UK centres as part of first-line treatment of patients with ovarian cancer at high risk of progression [International Federation of Gynecology and Obstetrics (FIGO) stage IV, or suboptimally debulked stage III] based on the results of phase III trials such as ICON-7. Its impact in patients treated outside clinical trials is, however, still unknown. In this study, we investigated patient characteristics, treatment patterns, adverse events and progression-free survival in 'real-world' patients in South West Wales. A total of 60 patients, treated between 2012 and 2015, were included in the study. Patient characteristics were less favourable compared to the bevacizumab-treated high-risk group in the ICON-7 trial (median age: 66 vs. 60 years; stage IV: 58% vs. 42%; performance status 0: 18% vs. 41%); 75% had received neoadjuvant chemotherapy before starting bevacizumab. After a median treatment duration of 8 months (range=0-34 months), 45 patients (75%) had experienced disease progression and 34 (56.7%) had died. Median progression-free survival was 16 months (95% confidence interval=14.4-17.6 months). The most common toxicities consisted of proteinuria (66.7%, all grade 1) and grade 1-2 hypertension (15%). Cardiovascular incidents, two of which were fatal, occurred in 6.7% of patients. In conclusion, our study provides encouraging evidence that the routine use of bevacizumab as part of first-line treatment of patients with ovarian cancer at high risk of progression may be associated with outcomes comparable with those obtained in clinical trials.
authors.affiliation: Department of Oncology, Singleton Hospital, Swansea, U.K. Gian.bertelli@wales.nhs.uk.
authors.forename: Gianfilippo
authors.initials: G
authors.lastname: Bertelli
authors.affiliation: Department of Gynaecological Oncology, Singleton Hospital, Swansea, U.K.
authors.forename: Florian
authors.initials: F
authors.lastname: Drews
authors.affiliation: Department of Gynaecological Oncology, Singleton Hospital, Swansea, U.K.
authors.forename: Kerryn
authors.initials: K
authors.lastname: Lutchman-Singh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000068258:Bevacizumab / Q000008:administration & dosage* / Q000009:adverse effects; D016190:Carboplatin / Q000008:administration & dosage; D002318:Cardiovascular Diseases / Q000139:chemically induced / Q000473:pathology*; D017326:Clinical Trials, Phase III as Topic; D018572:Disease-Free Survival; D064420:Drug-Related Side Effects and Adverse Reactions / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D017239:Paclitaxel / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D000068258:Bevacizumab; D016190:Carboplatin; D017239:Paclitaxel
keywords: Ovarian cancer; adjuvant/neoadjuvant chemotherapy; bevacizumab; carboplatin and paclitaxel; maintenance treatment