title: Viral Diversity, Prey Preference, and Bartonella Prevalence in Desmodus rotundus in Guatemala.
abstract: Certain bat species serve as natural reservoirs for pathogens in several key viral families including henipa-, lyssa-, corona-, and filoviruses, which may pose serious threats to human health. The Common Vampire Bat (Desmodus rotundus), due to its abundance, sanguivorous feeding habit involving humans and domestic animals, and highly social behavioral ecology, may have an unusually high potential for interspecies disease transmission. Previous studies have investigated rabies dynamics in D. rotundus, yet the diversity of other viruses, bacteria, and other microbes that these bats may carry remains largely unknown. We screened 396 blood, urine, saliva, and fecal samples from D. rotundus captured in Guatemala for 13 viral families and genera. Positive results were found for rhabdovirus, adenovirus, and herpesvirus assays. We also screened these samples for Bartonella spp. and found that 38% of individuals tested positive. To characterize potential for interspecies transmission associated with feeding behavior, we also analyzed cytochrome B sequences from fecal samples to identify prey species and found that domestic cattle (Bos taurus) made up the majority of blood meals. Our findings suggest that the risk of pathogen spillover from Desmodus rotundus, including between domestic animal species, is possible and warrants further investigation to characterize this microbial diversity and expand our understanding of foraging ecology in their populations.
authors.affiliation: Department of Ecology, Evolution, and Environmental Biology, Columbia University, New York, NY, USA.
authors.forename: Amy K
authors.initials: AK
authors.lastname: Wray
authors.affiliation: EcoHealth Alliance, 460 W. 34th Street, Suite 1701, New York, NY, 11231, USA. olival@ecohealthalliance.org.
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Olival
authors.affiliation: Center for Health Studies, Universidad del Valle de Guatemala, Guatemala City, Guatemala.
authors.forename: David
authors.initials: D
authors.lastname: Morán
authors.affiliation: Center for Health Studies, Universidad del Valle de Guatemala, Guatemala City, Guatemala.
authors.forename: Maria Renee
authors.initials: MR
authors.lastname: Lopez
authors.affiliation: Center for Health Studies, Universidad del Valle de Guatemala, Guatemala City, Guatemala.
authors.forename: Danilo
authors.initials: D
authors.lastname: Alvarez
authors.affiliation: Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA.
authors.forename: Isamara
authors.initials: I
authors.lastname: Navarrete-Macias
authors.affiliation: EcoHealth Alliance, 460 W. 34th Street, Suite 1701, New York, NY, 11231, USA.|Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA.
authors.forename: Eliza
authors.initials: E
authors.lastname: Liang
authors.affiliation: American Museum of Natural History, New York, NY, USA.
authors.forename: Nancy B
authors.initials: NB
authors.lastname: Simmons
authors.affiliation: Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA.
authors.forename: W Ian
authors.initials: WI
authors.lastname: Lipkin
authors.affiliation: EcoHealth Alliance, 460 W. 34th Street, Suite 1701, New York, NY, 11231, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Daszak
authors.affiliation: EcoHealth Alliance, 460 W. 34th Street, Suite 1701, New York, NY, 11231, USA.|Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA.
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Anthony
mesh_terms: D000818:Animals; D001473:Bartonella / Q000472:pathogenicity*; D002417:Cattle; D002685:Chiroptera / Q000382:microbiology*; D006166:Guatemala / Q000453:epidemiology; D006801:Humans; D015995:Prevalence; D011818:Rabies / Q000453:epidemiology / Q000635:transmission
keywords: Bartonella; Chiroptera; adenovirus; bats; disease ecology; feeding preference; herpesvirus; pathogen discovery; rhabdovirus; viral