title: Effects of receptor correlations on molecular information transmission.
abstract: Cells measure concentrations of external ligands by capturing ligand molecules with cell surface receptors. The numbers of molecules captured by different receptors co-vary because they depend on the same extrinsic ligand fluctuations. However, these numbers also counter-vary due to the intrinsic stochasticity of chemical processes because a single molecule randomly captured by a receptor cannot be captured by another. Such structure of receptor correlations is generally believed to lead to an increase in information about the external signal compared to the case of independent receptors. We analyze a solvable model of two molecular receptors and show that, contrary to this widespread expectation, the correlations have a small and negative effect on the information about the ligand concentration. Further, we show that measurements that average over multiple receptors are almost as informative as those that track the states of every individual one.
authors.affiliation: Department of Physics, Emory University, Atlanta, Georgia 30322, USA.|Computational Neuroscience Initiative, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
authors.forename: Vijay
authors.initials: V
authors.lastname: Singh
authors.affiliation: Department of Physics, Emory University, Atlanta, Georgia 30322, USA.|Department of Physics, Lamar University, Beaumont, Texas 77710, USA.
authors.forename: Martin
authors.initials: M
authors.lastname: Tchernookov
authors.affiliation: Department of Physics, Emory University, Atlanta, Georgia 30322, USA.|Department of Biology, Emory University, Atlanta, Georgia 30322, USA.
authors.forename: Ilya
authors.initials: I
authors.lastname: Nemenman
mesh_terms: D002468:Cell Physiological Phenomena; D008024:Ligands; D011485:Protein Binding; D011956:Receptors, Cell Surface / Q000378:metabolism
chemical_list: D008024:Ligands; D011956:Receptors, Cell Surface