title: A systematic review on phenolic compounds in Passiflora plants: Exploring biodiversity for food, nutrition, and popular medicine.
abstract: Passiflora plants are strategic in the context of biodiversity for food and nutrition. We applied the procedures of a systematic review protocol to study the state of the art on identification of phenolic compounds from Passiflora plants. An automated literature search was conducted using six databases and a combination of seven keywords. All the analytical, chromatographic, and spectroscopic methods were included. The studies were classified according to their method of identification, phenolic classes, and method of extraction. In total, 8,592 abstracts were found, from which 122 studies were selected for complete reading and 82 were selected for further analysis. Techniques of extraction, evaluated parts of the plant and methods of identification were systematized. Studies with leaves were most conspicuous (54.4%), 34 species of Passiflora were evaluated and orientin, isoorientin, vitexin, isovitexin were commonly found structures. A High Performance Liquid Chromatography-diode array detector was the technique most applied, with which the same structures were identified all through the studies, although other unknown structures were detected, but not elucidated. The use of Nuclear Magnetic Resonance and Mass Spectrometry, which are more sensitive techniques, needs to be intensified, to identify other unconventional compounds detected in Passiflora, to enhance the comprehension of the bioactive compounds in these plants.
authors.affiliation: a Department of Nutrition, Faculty of Health Sciences , Campus Universitário Darcy Ribeiro, Universidade de Brasília , Brasília , DF , Brazil.
authors.forename: Izabel Lucena
authors.initials: IL
authors.lastname: Gadioli
authors.affiliation: a Department of Nutrition, Faculty of Health Sciences , Campus Universitário Darcy Ribeiro, Universidade de Brasília , Brasília , DF , Brazil.
authors.forename: Marcela de Sá Barreto
authors.identifier: http://orcid.org/0000-0002-1388-033X
authors.initials: MSB
authors.lastname: da Cunha
authors.affiliation: a Department of Nutrition, Faculty of Health Sciences , Campus Universitário Darcy Ribeiro, Universidade de Brasília , Brasília , DF , Brazil.
authors.forename: Mariana Veras Oliveira
authors.initials: MVO
authors.lastname: de Carvalho
authors.affiliation: b Embrapa Cerrados, Laboratory of Food Science , Planaltina, Federal District , Brazil.
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Costa
authors.affiliation: a Department of Nutrition, Faculty of Health Sciences , Campus Universitário Darcy Ribeiro, Universidade de Brasília , Brasília , DF , Brazil.
authors.forename: Lívia de Lacerda de Oliveira
authors.identifier: http://orcid.org/0000-0001-5410-8752
authors.initials: LLO
authors.lastname: Pineli
mesh_terms: D047310:Apigenin / Q000032:analysis; D005419:Flavonoids / Q000032:analysis*; D005504:Food Analysis; D005960:Glucosides / Q000032:analysis; D047311:Luteolin / Q000032:analysis; D029598:Passiflora / Q000737:chemistry*; D010636:Phenols / Q000032:analysis; D064209:Phytochemicals / Q000032:analysis*; D010936:Plant Extracts / Q000737:chemistry
chemical_list: D005419:Flavonoids; D005960:Glucosides; D010636:Phenols; D064209:Phytochemicals; D010936:Plant Extracts; D047310:Apigenin; C032731:vitexin; C057912:homoorientin; C065886:orientin; C049772:isovitexin; D047311:Luteolin
keywords: Passiflora; antioxidants; bioactive compounds; chromatography; phenolics extraction; spectroscopy