title: InsP3R, the calcium whisperer: Maintaining mitochondrial function in cancer.
abstract: Mitochondrial metabolism is essential to fulfill the large demand for macromolecule biosynthesis in cancer. We recently identified low-level InsP3R-mediated Ca(2+) transfer to mitochondria as an unexpected requirement for mitochondrial function. Here we reveal that its absence specifically targets cancer cells and causes necrosis at daughter cell separation during ongoing proliferation.
authors.affiliation: Center for Neuroscience Research, Tufts University School of Medicine , Boston, MA, USA.
authors.forename: Alenka
authors.initials: A
authors.lastname: Lovy
authors.affiliation: Departments of Physiology and Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA, USA.
authors.forename: J Kevin
authors.initials: JK
authors.lastname: Foskett
authors.affiliation: Anatomy and Developmental Biology Program, Institute of Biomedical Sciences, University of Chile, Santiago, Chile; Geroscience Center for Brain Health and Metabolism, Santiago, Chile.
authors.forename: César
authors.initials: C
authors.lastname: Cárdenas
keywords: AMPK; MCU; OXPHOS; autophagy; cell cycle; necrosis