title: Biomarkers for Early Diagnosis of Acute Kidney Injury: Current Progress and Clinical Prospects.
abstract: Acute kidney injury (AKI) is one of the most common complications in critically ill patients, resulting in high morbidity and mortality. AKI usually occurs after major surgery, severe infection or drug-induced nephrotoxicity and is associated with prolonged hospital stays, increased costs and adverse clinical outcomes. The diagnosis of AKI is currently based on decreased glomerular filtration rate (GFR) and urine output, and increased serum creatinine. Novel biomarkers are required for early identification of patients with AKI to allow timely therapy and improve patient outcomes. With the advent of proteomics and genomics techniques, a vast array of biomarkers are now available in clinical practice.
authors.affiliation: Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou. China.
authors.forename: Hong-Feng
authors.initials: HF
authors.lastname: Huang
authors.affiliation: Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou. China.
authors.forename: Jing-Yi
authors.initials: JY
authors.lastname: Zhou
authors.affiliation: Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Qingchun Road 79, Hangzhou. China.
authors.forename: Jiang-Hua
authors.initials: JH
authors.lastname: Chen
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000175:diagnosis* / Q000473:pathology / Q000652:urine; D015415:Biomarkers / Q000097:blood / Q000652:urine; D003404:Creatinine / Q000097:blood; D016638:Critical Illness; D055316:Cystatin C / Q000097:blood*; D042241:Early Diagnosis; D050556:Fatty Acid-Binding Proteins / Q000652:urine*; D005919:Glomerular Filtration Rate; D000072596:Hepatitis A Virus Cellular Receptor 1 / Q000378:metabolism*; D006801:Humans; D020382:Interleukin-18 / Q000097:blood / Q000652:urine*; D000071068:Lipocalin-2 / Q000652:urine*; D011237:Predictive Value of Tests; D000074083:Sodium-Hydrogen Exchanger 3; D017923:Sodium-Hydrogen Exchangers / Q000652:urine*; D016482:Urinalysis
chemical_list: D015415:Biomarkers; D055316:Cystatin C; C493319:FABP1 protein, human; D050556:Fatty Acid-Binding Proteins; C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; C000589760:IL18 protein, human; D020382:Interleukin-18; C489506:LCN2 protein, human; D000071068:Lipocalin-2; C000613385:SLC9A3 protein, human; D000074083:Sodium-Hydrogen Exchanger 3; D017923:Sodium-Hydrogen Exchangers; D003404:Creatinine
keywords: Acute kidney injury; IL-18; KIM-1; L-FABP; NGAL; NHE-3; biomarkers; cystatin C