title: Hydrodynamic collective effects of active proteins in biological membranes.
abstract: Lipid bilayers forming biological membranes are known to behave as viscous two-dimensional fluids on submicrometer scales; usually they contain a large number of active protein inclusions. Recently, it was shown [A. S. Mikhailov and R. Kapral, Proc. Natl. Acad. Sci. USA 112, E3639 (2015)PNASA60027-842410.1073/pnas.1506825112] that such active proteins should induce nonthermal fluctuating lipid flows leading to diffusion enhancement and chemotaxislike drift for passive inclusions in biomembranes. Here, a detailed analytical and numerical investigation of such effects is performed. The attention is focused on the situations when proteins are concentrated within lipid rafts. We demonstrate that passive particles tend to become attracted by active rafts and are accumulated inside them.
authors.affiliation: Department of Physics, Graduate School of Science, Chiba University, Chiba 263-8522, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Koyano
authors.affiliation: Department of Physics, Graduate School of Science, Chiba University, Chiba 263-8522, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kitahata
authors.affiliation: Abteilung Physikalische Chemie, Fritz-Haber-Institut der Max-Planck-Gesellschaft, 14195 Berlin, Germany.|Department of Mathematical and Life Sciences, Hiroshima University, Hiroshima 739-8526, Japan.
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Mikhailov
mesh_terms: D002462:Cell Membrane / Q000378:metabolism*; D004058:Diffusion; D057446:Hydrodynamics; D008051:Lipid Bilayers / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*
chemical_list: D008051:Lipid Bilayers; D011506:Proteins