title: 177Lu-DOTATATE PRRT in Recurrent Skull-Base Phosphaturic Mesenchymal Tumor Causing Osteomalacia: A Potential Application of PRRT Beyond Neuroendocrine Tumors.
abstract: The potential of peptide receptor radionuclide therapy (PRRT) is described in a case of recurrent inoperable phosphaturic mesenchymal tumor causing osteomalacia in the left basiocciput, for which the patient had undergone surgery twice previously. After one cycle of PRRT, there was good symptomatic improvement, with a modest reduction in uptake on both68Ga-DOTATATE PET/CT and18F-FDG PET/CT suggesting a favorable response. Hence, treatment with a second cycle was considered. Being somatostatin receptor-avid, this rare group of tumors when inoperable or recurrent may potentially be targeted with PRRT. Well-tolerated and noninvasive, PRRT could evolve as a promising targeted treatment approach in this clinical setting. In summary, tumor-induced osteomalacia with68Ga-DOTATATE-avid inoperable or recurrent tumor can be considered a potential clinical application for PRRT beyond neuroendocrine tumors.
authors.affiliation: Radiation Medicine Centre, Bhabha Atomic Research Centre, Parel, Mumbai, India drsanb@yahoo.com.
authors.forename: Sandip
authors.initials: S
authors.lastname: Basu
authors.affiliation: Radiation Medicine Centre, Bhabha Atomic Research Centre, Parel, Mumbai, India.
authors.forename: Preeti
authors.initials: P
authors.lastname: Fargose
mesh_terms: D005260:Female; D006801:Humans; D008875:Middle Aged; D009372:Neoplasms, Connective Tissue / Q000000981:diagnostic imaging / Q000209:etiology* / Q000378:metabolism / Q000532:radiotherapy*; D015282:Octreotide / Q000031:analogs & derivatives*; D009942:Organometallic Compounds; D010018:Osteomalacia; D010257:Paraneoplastic Syndromes; D000072078:Positron Emission Tomography Computed Tomography; D017481:Receptors, Somatostatin / Q000378:metabolism*; D012008:Recurrence; D012886:Skull
chemical_list: D009942:Organometallic Compounds; D017481:Receptors, Somatostatin; C447941:lutetium Lu 177 dotatate; D015282:Octreotide
keywords: 177Lu-DOTATATE PRRT; 68Ga-DOTATATE PET/CT; oncogenic osteomalacia; tumor-induced osteomalacia