title: GDF-15 and Hepcidin Levels in Nonanemic Patients with Impaired Glucose Tolerance.
abstract: Aims. Growth Differentiation Factor-15 (GDF-15) has been suggested as one of the regulators of hepcidin, an important regulatory peptide for iron deposition. Current data is conflicting about the relationship between hepcidin and disorders of glucose metabolism. We aimed to investigate serum hepcidin and GDF-15 concentrations and their associations with each other, in nonanemic subjects with impaired glucose tolerance (IGT) in comparison with the nonanemic subjects with normal glucose tolerance (NGT). Methods. Thirty-seven subjects with IGT and 32 control subjects with NGT, who were age-, gender-, and body mass index- (BMI-) matched, were included in the study. Results. Serum GDF-15 levels were significantly higher in IGT compared to NGT. There were no differences in hepcidin, interleukin-6, and high sensitive C-reactive protein levels between the groups. We found a positive correlation between GDF-15 and hepcidin levels. There were also positive correlations between GDF-15 and age, uric acid, creatinine, and area under the curve for glucose (AUC-G). Hepcidin was correlated positively with ferritin levels. In the multiple regression analysis, GDF-15 concentrations were independently associated with age, uric acid, and AUC-G. Conclusions. Impaired glucose tolerance is associated with increased GDF-15 levels even in the absence of anemia, but the levels of hepcidin are not significantly altered in prediabetic state.
authors.affiliation: Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, 06560 Ankara, Turkey.
authors.forename: Mehmet Muhittin
authors.identifier: 0000-0002-1041-6881
authors.initials: MM
authors.lastname: Yalcin
authors.affiliation: Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, 06560 Ankara, Turkey.
authors.forename: Alev Eroglu
authors.initials: AE
authors.lastname: Altinova
authors.affiliation: Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, 06560 Ankara, Turkey.
authors.forename: Mujde
authors.initials: M
authors.lastname: Akturk
authors.affiliation: Department of Biochemistry, Gazi University Faculty of Medicine, 06560 Ankara, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Gulbahar
authors.affiliation: Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, 06560 Ankara, Turkey.
authors.forename: Emre
authors.initials: E
authors.lastname: Arslan
authors.affiliation: Department of Internal Medicine, Gazi University Faculty of Medicine, 06560 Ankara, Turkey.
authors.forename: Damla
authors.initials: D
authors.lastname: Ors Sendogan
authors.affiliation: Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, 06560 Ankara, Turkey.
authors.forename: Ilhan
authors.initials: I
authors.lastname: Yetkin
authors.affiliation: Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, 06560 Ankara, Turkey.
authors.forename: Fusun Balos
authors.initials: FB
authors.lastname: Toruner
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D005293:Ferritins / Q000097:blood; D018149:Glucose Intolerance / Q000097:blood*; D055436:Growth Differentiation Factor 15 / Q000097:blood*; D064451:Hepcidins / Q000097:blood*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged
chemical_list: D055436:Growth Differentiation Factor 15; D064451:Hepcidins; D015850:Interleukin-6; D002097:C-Reactive Protein; D005293:Ferritins