title: Preventive Effect of Dihydromyricetin against Cisplatin-Induced Nephrotoxicity In Vitro and In Vivo.
abstract: Nephrotoxicity is a frequent severe side effect of cisplatin chemotherapy, limiting its clinical use despite being one of the most potent chemotherapy drugs. Dihydromyricetin is a highly abundant compound purified from the leaves of Ampelopsis grossedentata. Previous studies have demonstrated the anti-inflammatory and antioxidative effects of Dihydromyricetin both in vitro and in vivo, but little is known about the effects of Dihydromyricetin on cisplatin-induced nephrotoxicity and its underlying mechanisms. In the present study, we investigated its potential renoprotective effect and found that Dihydromyricetin ameliorated the renal functional impairment and structural damage caused by cisplatin. Moreover, Dihydromyricetin markedly attenuated cisplatin-induced oxidative stress, as well as protecting against cisplatin-induced inflammation and apoptotic cell death in mouse kidney tissues. These results collectively highlight the potential of DMY as a rational renoprotective agent against cisplatin.
authors.affiliation: Center for Stem Cell & Regenerative Medicine, The Second Hospital of Shandong University, Jinan 250012, China.
authors.forename: Fei
authors.identifier: 0000-0001-7917-0819
authors.initials: F
authors.lastname: Wu
authors.affiliation: Department of Joint Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China.
authors.forename: Yi
authors.identifier: 0000-0002-4602-2518
authors.initials: Y
authors.lastname: Li
authors.affiliation: Center for Stem Cell & Regenerative Medicine, The Second Hospital of Shandong University, Jinan 250012, China.
authors.forename: Haibo
authors.identifier: 0000-0003-1077-0466
authors.initials: H
authors.lastname: Song
authors.affiliation: Center for Stem Cell & Regenerative Medicine, The Second Hospital of Shandong University, Jinan 250012, China.
authors.forename: Yuan
authors.identifier: 0000-0001-5977-1895
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Center for Stem Cell & Regenerative Medicine, The Second Hospital of Shandong University, Jinan 250012, China.
authors.forename: Yuzhu
authors.identifier: 0000-0003-2882-3992
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Center for Stem Cell & Regenerative Medicine, The Second Hospital of Shandong University, Jinan 250012, China.
authors.forename: Miao
authors.identifier: 0000-0001-6194-8813
authors.initials: M
authors.lastname: Jiang
authors.affiliation: Center for Stem Cell & Regenerative Medicine, The Second Hospital of Shandong University, Jinan 250012, China.
authors.forename: Fang
authors.identifier: 0000-0002-6553-3890
authors.initials: F
authors.lastname: Wang
authors.affiliation: Center for Stem Cell & Regenerative Medicine, The Second Hospital of Shandong University, Jinan 250012, China.
authors.forename: Qian
authors.identifier: 0000-0002-9839-1980
authors.initials: Q
authors.lastname: Mu
authors.affiliation: Center for Stem Cell & Regenerative Medicine, The Second Hospital of Shandong University, Jinan 250012, China.
authors.forename: Wen
authors.identifier: 0000-0002-9532-917X
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Center for Stem Cell & Regenerative Medicine, The Second Hospital of Shandong University, Jinan 250012, China.
authors.forename: Liang
authors.identifier: 0000-0003-2771-0910
authors.initials: L
authors.lastname: Li
authors.affiliation: Center for Stem Cell & Regenerative Medicine, The Second Hospital of Shandong University, Jinan 250012, China.
authors.forename: Dongqi
authors.identifier: 0000-0001-8023-1252
authors.initials: D
authors.lastname: Tang