title: [Comparison among measures to prevent intrauterine adhesions after artificial abortion].
abstract: OBJECTIVE
  To investigate the clinical efficacy of oral medicine and sodium hyaluronate in prevention of intrauterine adhesions after artificial abortion.
  
  
  METHODS
  A total of 572 patients with early pregnancy termination through artificial abortion, who experienced two or more times of abortion, were retrospectively analyzed. Patients were randomly and voluntarily divided into 4 groups: an artificial cycle group, a drospirenone and ethinylestradiol tablets group, a sodium hyaluronate group, and a control group. The thickness of the endometrium, return time of menses, and the status of intrauterine adhesions were observed.
  
  
  RESULTS
  The thickness of the endometrium in the artificial period group was greater than that in the control group (P<0.001). It was less in the drospirenone and ethinylestradiol tablets group comparing with that in the control group (P<0.001). There was no significant difference in the thickness of the endometrium between the sodium hyaluronate group and the control group (P=0.717). Return time of menses in the artificial menstrual cycle group and the drospirenone and ethinylestradiol tablets group was shorter than that in the control group (P<0.001). There was no significant difference in return time of menses between the sodium hyaluronate group and the control group (P=0.813). The incidence of intrauterine adhesions could be reduced by the 3 preventive measures (All P<0.01).
  
  
  CONCLUSIONS
  Drugs for artificial cycle and drospirenone and ethinylestradiol tablets medication immediately after artificial abortion can effectively promote endometrial repair and reduce the incidence of intrauterine adhesions. However, for the patients with poor compliance, drospirenoneand ethinylestradiol tablets are the first choice for prevention of intrauterine adhesion.
authors.affiliation: Department of Obstetrics and Gynecology, Third Affiliated Hospital, Zhengzhou University, Zhengzhou 450000, China beileili2004@126.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Obstetrics and Gynecology, Third Affiliated Hospital, Zhengzhou University, Zhengzhou 450000, China.
authors.forename: Manman
authors.initials: M
authors.lastname: Nai
authors.affiliation: Department of Obstetrics and Gynecology, Third Affiliated Hospital, Zhengzhou University, Zhengzhou 450000, China.
authors.forename: Guixiang
authors.initials: G
authors.lastname: Gao
authors.affiliation: Department of Obstetrics and Gynecology, Third Affiliated Hospital, Zhengzhou University, Zhengzhou 450000, China.
authors.forename: Luwen
authors.initials: L
authors.lastname: Wang
mesh_terms: D000028:Abortion, Induced / Q000009:adverse effects*; D000736:Androstenes / Q000494:pharmacology / Q000627:therapeutic use*; D004717:Endometrium / Q000033:anatomy & histology / Q000187:drug effects; D004997:Ethinyl Estradiol / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D008597:Menstrual Cycle / Q000187:drug effects; D008598:Menstruation / Q000187:drug effects; D011247:Pregnancy; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control*
chemical_list: D000736:Androstenes; D004997:Ethinyl Estradiol; D006820:Hyaluronic Acid; C035144:drospirenone