title: Euonymus alatus: A Review on Its Phytochemistry and Antidiabetic Activity.
abstract: Euonymus alatus (E. alatus) is a medicinal plant used in some Asian countries for treating various conditions including cancer, hyperglycemia, and diabetic complications. This review outlines the phytochemistry and bioactivities of E. alatus related to antidiabetic actions. More than 100 chemical constituents have been isolated and identified from E. alatus, including flavonoids, terpenoids, steroids, lignans, cardenolides, phenolic acids, and alkaloids. Studies in vitro and in vivo have demonstrated the hypoglycemic activity of E. alatus extracts and its certain constituents. The hypoglycemic activity of E. alatus may be related to regulation of insulin signaling and insulin sensitivity, involving PPARγ and aldose reductase pathways. Further studies on E. alatus and its bioactive compounds may help to develop new agents for treating diabetes and diabetic complications.
authors.affiliation: Traditional & Complementary Medicine Program, School of Health Sciences, RMIT University, Bundoora, VIC 3083, Australia; School of Pharmaceutical Sciences, Xi'an Medical University, Xi'an 710021, China.
authors.forename: Xifeng
authors.initials: X
authors.lastname: Zhai
authors.affiliation: Traditional & Complementary Medicine Program, School of Health Sciences, RMIT University, Bundoora, VIC 3083, Australia.
authors.forename: George Binh
authors.identifier: 0000-0002-1315-5242
authors.initials: GB
authors.lastname: Lenon
authors.affiliation: Traditional & Complementary Medicine Program, School of Health Sciences, RMIT University, Bundoora, VIC 3083, Australia.
authors.forename: Charlie C L
authors.identifier: 0000-0001-6937-9088
authors.initials: CC
authors.lastname: Xue
authors.affiliation: Traditional & Complementary Medicine Program, School of Health Sciences, RMIT University, Bundoora, VIC 3083, Australia; National Institute of Complementary Medicine, Western Sydney University, Penrith, NSW 2751, Australia.
authors.forename: Chun-Guang
authors.identifier: 0000-0002-7789-2209
authors.initials: CG
authors.lastname: Li