title: Physiological and Biochemical Mechanisms of Lifespan Regulation in Rats Kept Under Various Light Conditions.
abstract: The present study was aimed to identify how age-related changes in some physiological and biochemical systems are related to changes in the life span of rats with long-term pineal gland hypo- and hyperfunction induced by constant light and constant darkness, respectively.
  
  
  
  At the age of 25 days the rats were randomly divided into 3 groups: standard light/dark regimen (LD), constant light (LL) and constant darkness (DD). Age-related Antioxidant System (AOS) changes in liver tissues, alteration of immunoreactivity in blood smears were investigated, pubescence and lifespan of the animals were determined.
  
  
  
  Modification of the level of melatonin synthesis induced by constant light results in interrelated rearrangements in the functioning of the investigated physiological systems. Elevated activity of the antioxidant system extends the lifespan, while at the same time slowing down pubescence and altering the morpho-functional properties of leukocytes in blood.
  
  
  
  The absence of light/dark alternation (constant light and constant darkness) affects only those physiological indices that follow the organism's circadian rhythms (Activity of Antioxidant Enzymes (AOE), levels of individual immune system cell types), whereas changes in the parameters not governed by circadian fluctuations (vitamin concentrations, pubescence, and aging) depend on the level of melatonin produced by the pineal gland.
authors.affiliation: Institute of Biology, Karelian Research Centre, Russian Academy of Sciences. 185910, Petrozavodsk, Russia.
authors.forename: Evgeniy A
authors.initials: EA
authors.lastname: Khizhkin
authors.forename: Victor A
authors.initials: VA
authors.lastname: Ilukha
authors.forename: Irina A
authors.initials: IA
authors.lastname: Vinogradova
authors.forename: Lyudmila B
authors.initials: LB
authors.lastname: Uzenbaeva
authors.forename: Tatiana N
authors.initials: TN
authors.lastname: Ilyina
authors.forename: Victoria D
authors.initials: VD
authors.lastname: Yunash
authors.forename: Artem V
authors.initials: AV
authors.lastname: Morozov
authors.forename: Vladimir N
authors.initials: VN
authors.lastname: Anisimov
mesh_terms: D000375:Aging / Q000276:immunology / Q000378:metabolism / Q000528:radiation effects; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D003624:Darkness; D005260:Female; D008027:Light; D008099:Liver / Q000378:metabolism; D008136:Longevity / Q000276:immunology / Q000502:physiology / Q000528:radiation effects*; D008297:Male; D008550:Melatonin / Q000378:metabolism; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D008550:Melatonin