title: Association of Poly (ADP-Ribose) Polymerase 1 Variants with Oral Squamous Cell Carcinoma Susceptibility in a South Indian Population.
abstract: BACKGROUND
  Oral cancers account for approximately 2% of all cancers diagnosed each year; however, the vast majority (80%) of the affected individuals are smokers whose risk of developing a lesion is five to nine times greater than that of non-smokers. Tobacco smoke contains numerous carcinogens that cause DNA damage, including oxidative lesions that are removed effectively by the base-excision repair (BER) pathway, in which poly (ADP-ribose) polymerase 1 (PARP-1), plays key roles. Genetic variations in the genes encoding DNA repair enzymes may alter their functions. Several studies reported mixed effects on the association between PARP-1 variants and the risk of cancer development. Till now no reported studies have investigated the association between PARP-1 variants and oral squamous cell carcinoma (OSCC) risk in an Indian population.
  
  
  METHODS
  In the present case control study 100 OSCC patients and 100 matched controls were genotyped using PARP1 single nucleotide peptides (SNP's) rs1136410 and rs3219090 using TaqMan assays.
  
  
  RESULTS
  The results indicated significantly higher risk with PARP1 rs1136410 minor allele "C" (OR=1.909; p=0.02942; CI, 1.060- 3.439). SNP rs1136410 also showed significantly increased risk in patients with smoking habit at C/C genotype and at minor allele C.
  
  
  CONCLUSIONS
  The PAPR-1 Ala762Val polymorphism may play a role in progression of OSCC. Larger studies with a greater number of samples are needed to verify these findings.
authors.affiliation: Department of Preventive Dental Sciences, College of Dentistry, Prince Sattam Bin Abdulaziz University, Al-Kharj, India E-mail : darshandevang@gmail.com.
authors.forename: Sukumaran
authors.initials: S
authors.lastname: Anil
authors.forename: P B
authors.initials: PB
authors.lastname: Gopikrishnan
authors.forename: Ashik Bin
authors.initials: AB
authors.lastname: Basheer
authors.forename: B G
authors.initials: BG
authors.lastname: Vidyullatha
authors.forename: Yahya A
authors.initials: YA
authors.lastname: Alogaibi
authors.forename: Elna P
authors.initials: EP
authors.lastname: Chalisserry
authors.forename: Fawad
authors.initials: F
authors.lastname: Javed
authors.forename: M Hn
authors.initials: MH
authors.lastname: Dalati
authors.forename: Sajith
authors.initials: S
authors.lastname: Vellappally
authors.forename: Mohamed Ibrahim
authors.initials: MI
authors.lastname: Hashem
authors.forename: Darshan Devang
authors.initials: DD
authors.lastname: Divakar
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000235:genetics*; D016022:Case-Control Studies; D004260:DNA Repair / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000209:etiology / Q000235:genetics*; D000071137:Poly (ADP-Ribose) Polymerase-1 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
chemical_list: C499320:PARP1 protein, human; D000071137:Poly (ADP-Ribose) Polymerase-1