title: [INFLUENCE OF EMOTIONAL STRESS ON CELLULAR IMMUNITY EXPOSED TO LOW DOSE OF GAMMA-RADIATION IN THE REMOTE PERIOD (EXPERIMENTAL STUDY)].
abstract: The study aim was to investigate the combined influence of emotional stress and low doses of ionizing radiation (0.2 Gr) on cellular immunity of laboratory animals in the remote period. One hundred and twenty Wistar rats were divided into 4 groups: 1 group control, 2 group - exposed to gamma-radiation, 3 group - exposed to emotional stress, 4 group was exposed to the combined influence of emotional stress and gamma-radiation. Emotional stress was simulated by tail suspension. Animals from groups 2 and 4 were exposed to a single dose of 0.2 Gr 90 days prior the investigation via «TERAGAM» 60Co (ISOTREND spol. s.r.o., Check Republic). The results of our study show that in a remote period after exposure to a low dose of gamma-radiation the decrease of quantitative and increase of qualitative indicators of cellular immunity are observed, which is manifested by lymphopenia and decease of CD3+- CD4+ - and CD8+-lymphocytes subpopulations, and lymphokin-producing capacity of leucocytes. The late phase of stress-reaction is characterized by lymphocytosis, increase in absolute numbers of CD3+- and CD4+- lymphocytes, normal range of CD8+- cells and lymphokin-producing capacity of leucocytes and decrease of immunoregulatory index.
authors.affiliation: The State Medical University; Kazakh Humanitarian-Juridical Innovative University, Semey, Kazakhstan.
authors.forename: A
authors.initials: A
authors.lastname: Utegenova
authors.affiliation: The State Medical University; Kazakh Humanitarian-Juridical Innovative University, Semey, Kazakhstan.
authors.forename: B
authors.initials: B
authors.lastname: Zhetpisbayev
authors.affiliation: The State Medical University; Kazakh Humanitarian-Juridical Innovative University, Semey, Kazakhstan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Semenova
authors.affiliation: The State Medical University; Kazakh Humanitarian-Juridical Innovative University, Semey, Kazakhstan.
authors.forename: A
authors.initials: A
authors.lastname: Kydyrmoldina
authors.affiliation: The State Medical University; Kazakh Humanitarian-Juridical Innovative University, Semey, Kazakhstan.
authors.forename: A
authors.initials: A
authors.lastname: Argynbekova
mesh_terms: D000818:Animals; D017252:CD3 Complex / Q000097:blood; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000528:radiation effects; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D007111:Immunity, Cellular / Q000528:radiation effects*; D007962:Leukocytes / Q000276:immunology / Q000528:radiation effects*; D008222:Lymphokines / Q000097:blood; D008231:Lymphopenia / Q000097:blood / Q000276:immunology; D008297:Male; D011833:Radiation Injuries, Experimental / Q000276:immunology*; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000276:immunology*
chemical_list: D017252:CD3 Complex; D008222:Lymphokines