title: Office-Based vs Traditional Operating Room Management of Recurrent Respiratory Papillomatosis: Impact of Patient Characteristics and Disease Severity.
abstract: Management of recurrent respiratory papillomatosis (RRP) in adults has evolved to include office-based laser techniques.
  
  
  
  To determine whether demographic or disease characteristics differ between patients undergoing office-based (office group) vs traditional operating room (OR group) surgical approaches for RRP.
  
  
  
  This study was a medical record review of adult patients with RRP treated between January 2011 and September 2013 at a tertiary care center. Patients were divided into 2 groups according to the setting in which the patient had the most procedures during the past 2 years.
  
  
  
  Demographic and disease characteristics were compared between patients receiving predominantly office-based vs predominantly OR management.
  
  
  
  Of 57 patients (47 male and 10 female, with a mean [SD] age of 53.5 [16.4] years) treated during the 2-year period, 34 patients underwent predominantly office-based management and 23 patients underwent predominantly OR management. Sex, age, and weight were not statistically significantly different between the 2 groups. Patients in the OR group had a younger age at RRP diagnosis (mean [SD], 28.7 [22.0] years in the OR group and 45.5 [20.5] years in the office group), with a mean difference of 16.8 years (95% CI, -28.3 to -5.4 years). Patients in the OR group also had a significantly higher Derkay score (mean [SD], 15.1 [5.7] in the OR group and 10.7 [5.0] in the office group), with a mean difference of 4.4 (95% CI, 1.6-7.3). No statistically significant differences in comorbidities were observed between the 2 groups except for type 1 or 2 diabetes, which was more common in the OR group. There were 5 patients (22%) with diabetes in the OR group and 1 patient (3%) with diabetes in the office group, with a mean difference of 19% (95% CI, 2.7%-35%). In a subanalysis that excluded patients with juvenile-onset RRP, Derkay score (mean [SD], 13.9 [4.5] in the OR group and 10.8 [5.1] in the office group), with a mean difference of 3.1 (95% CI, 0.5-6.1), and the incidence of diabetes (25% [4 of 16] in the OR group and 3% [1 of 31] in the office group), with a mean difference of 22% (95% CI, 3%-40%), remained significantly higher in the OR group, while age at diagnosis of RRP was no longer statistically significant (mean [SD], 40.2 [15.6] years in the OR group and 49.6 [16.4] years in the office group), with a mean difference of 9.4 years (95% CI, -19.4 to -0.7 years).
  
  
  
  There were no sex or age differences between patients with RRP treated in the office compared with those treated in the OR. Patients with earlier age at diagnosis of RRP and greater disease severity were more likely to be managed in the OR.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors.forename: Emel Çadalli
authors.initials: EÇ
authors.lastname: Tatar
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Washington School of Medicine, Seattle3Department of Otolaryngology-Head and Neck Surgery, University of Michigan Medical School, Ann Arbor.
authors.forename: Robbi A
authors.initials: RA
authors.lastname: Kupfer
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, College of Medicine, University of Arizona Medical Center, Tucson.
authors.forename: Jonnae Y
authors.initials: JY
authors.lastname: Barry
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University, Bethesda, Maryland.
authors.forename: Clint T
authors.initials: CT
authors.lastname: Allen
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Washington School of Medicine, Seattle.
authors.forename: Albert L
authors.initials: AL
authors.lastname: Merati
mesh_terms: D000328:Adult; D000367:Age Factors; D000556:Ambulatory Surgical Procedures / Q000706:statistics & numerical data*; D015331:Cohort Studies; D016001:Confidence Intervals; D019468:Disease Management; D005260:Female; D005500:Follow-Up Studies; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D009819:Office Visits / Q000706:statistics & numerical data; D009873:Operating Rooms / Q000706:statistics & numerical data*; D017063:Outcome Assessment, Health Care; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery*; D018579:Patient Selection; D011183:Postoperative Complications / Q000453:epidemiology / Q000503:physiopathology; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery*; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D012737:Sex Factors