title: Research on pediatric glomerular disease and normal kidney with shear wave based elastography point quantification.
abstract: OBJECTIVE
  To evaluate the renal cortex stiffness in children with glomerular disease by shear wave based elastography point quantification (ElastPQ), and to investigate the association between shear wave velocity (SWV) in the renal cortex and age in normal children, and the inter-gender differences.
  
  
  METHODS
  One hundred and five children who were pathologically confirmed with glomerular diseases were selected as the disease group. Meanwhile, 120 healthy children were selected as the control group. Effective values were measured 5 times at the same kidney sites on each side.
  
  
  RESULTS
  Comparisons of SWV measurements between left and right kidneys in the disease and control groups all showed significant differences (left kidney t = 6.896, P = 0.004; right kidney t = 7.415, P = 0.001). In the control group, left and right kidney SWV measurements were all positively correlated with age (left kidney r = 0.792, P = 0.003; right kidney r = 0.794, P = 0.004). Moreover, inter-gender difference was present in the right kidney measurements.
  
  
  CONCLUSIONS
  ElastPQ technology has certain advantages in predicting pediatric glomerular disease compared to conventional ultrasound. ElastPQ technology contributes to the early diagnosis of the disease.
authors.affiliation: Department of Ultrasound, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, 310003, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Xu
authors.affiliation: Department of Ultrasound, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, 310003, China.
authors.forename: Guoping
authors.initials: G
authors.lastname: Jiang
authors.affiliation: Department of Ultrasound, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, 310003, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Ye
authors.affiliation: Department of Ultrasound, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, 310003, China.
authors.forename: Jin
authors.initials: J
authors.lastname: He
authors.affiliation: Department of PICU, The Children's Hospital of Zhejiang University School of Medicine, No 57 Zhugan Lane, Xiacheng District, Hangzhou, 310003, China. xwfhz@hotmail.com.
authors.forename: Wangfang
authors.initials: W
authors.lastname: Xie
mesh_terms: D000293:Adolescent; D001707:Biopsy, Needle; D002648:Child; D002675:Child, Preschool; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007674:Kidney Diseases / Q000000981:diagnostic imaging*; D008297:Male
keywords: Child; Elastography; Kidney; Shear wave velocity; Ultrasound