title: Cytomegalovirus-associated thrombocytopenia treated with thrombopoietin receptor agonist.
abstract: Symptomatic cytomegalovirus (CMV) in immunocompetent individuals is an uncommon, yet recognised, phenomenon. This report discusses a case of CMV-associated thrombocytopenia refractory to immunomodulation and antivirals. Ultimately, a clinicopathological response was attained with eltrombopag. This is the first report of the efficacy of thrombopoietin receptor agonists in this context. This experience provides insight into possible pathogenic mechanisms of CMV-associated thrombocytopenia and presents a therapeutic option.
authors.affiliation: Departments of Haematology, St Vincent's Hospital, Sydney, New South Wales, Australia. jock.simpson@calvarymater.org.au.
authors.forename: J D
authors.identifier: http://orcid.org/0000-0002-1897-1732
authors.initials: JD
authors.lastname: Simpson
authors.affiliation: Departments of Infectious Disease, St Vincent's Hospital, Sydney, New South Wales, Australia.|Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
authors.forename: G V
authors.initials: GV
authors.lastname: Matthews
authors.affiliation: Department of Haematology, Prince of Wales Hospital, Sydney, New South Wales, Australia.
authors.forename: T A
authors.initials: TA
authors.lastname: Brighton
authors.affiliation: Departments of Haematology, St Vincent's Hospital, Sydney, New South Wales, Australia.
authors.forename: J E
authors.initials: JE
authors.lastname: Joseph
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D001565:Benzoates / Q000008:administration & dosage*; D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006834:Hydrazines / Q000008:administration & dosage*; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy*; D011720:Pyrazoles / Q000008:administration & dosage*; D053628:Receptors, Thrombopoietin / Q000819:agonists*
chemical_list: D000998:Antiviral Agents; D001565:Benzoates; D006834:Hydrazines; D011720:Pyrazoles; D053628:Receptors, Thrombopoietin; C520809:eltrombopag; D011241:Prednisone
keywords: cytomegalovirus; eltrombopag; immune thrombocytopenic purpura; platelets; treatment