title: The effect of maternal exposure to endocrine disrupting chemicals on fetal and neonatal development: A review on the major concerns.
abstract: There is a widespread exposure of general population, including pregnant women and developing fetuses, to the endocrine disrupting chemicals (EDCs). These chemicals have been reported to be present in urine, blood serum, breast milk, and amniotic fluid. Endocrine disruptions induced by environmental toxicants have placed a heavy burden on society, since environmental exposures during critical periods of development can permanently reprogram normal physiological responses, thereby increasing susceptibility to disease later in life-a process known as developmental reprogramming. During development, organogenesis and tissue differentiation occur through a continuous series of tightly-regulated and precisely-timed molecular, biochemical, and cellular events. Humans may encounter EDCs daily and during all stages of life, from conception and fetal development through adulthood and senescence. Nevertheless, prenatal and early postnatal windows are the most critical for proper development, due to rapid changes in system growth. Although there are still gaps in our knowledge, currently available data support the urgent need for health and environmental policies aimed at protecting the public and, in particular, the developing fetus and women of reproductive age. Birth Defects Research (Part C) 108:224-242, 2016. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Surgical and Medical Sciences and Translational Medicine, Sant'Andrea Hospital, University of Rome Sapienza.
authors.forename: Maddalena
authors.initials: M
authors.lastname: Mallozzi
authors.affiliation: Department of Surgical and Medical Sciences and Translational Medicine, Sant'Andrea Hospital, University of Rome Sapienza.
authors.forename: Giulia
authors.initials: G
authors.lastname: Bordi
authors.affiliation: Department of Surgical and Medical Sciences and Translational Medicine, Sant'Andrea Hospital, University of Rome Sapienza.
authors.forename: Chiara
authors.initials: C
authors.lastname: Garo
authors.affiliation: Department of Surgical and Medical Sciences and Translational Medicine, Sant'Andrea Hospital, University of Rome Sapienza. donatella.caserta@uniroma1.it.
authors.forename: Donatella
authors.initials: D
authors.lastname: Caserta
mesh_terms: D052244:Endocrine Disruptors / Q000009:adverse effects; D004703:Endocrine System; D004781:Environmental Exposure / Q000009:adverse effects; D004785:Environmental Pollutants / Q000009:adverse effects; D005260:Female; D047109:Fetal Development / Q000187:drug effects*; D005333:Fetus / Q000187:drug effects; D006801:Humans; D000068104:Infant Health; D018811:Maternal Exposure / Q000009:adverse effects*; D011247:Pregnancy; D012098:Reproduction / Q000187:drug effects
chemical_list: D052244:Endocrine Disruptors; D004785:Environmental Pollutants
keywords: development; endocrine disruptors; environment; pregnancy