title: Hepatosplenic T Cell Lymphoma in an Immunocompetent Female Diagnosed using Flow Cytometry: A Rare Clinical Entity.
abstract: Hepatosplenic T-cell lymphoma is a rare haematopoietic malignancy that comprises less than 1% of Non-Hodgkin lymphomas. We are reporting a case of a 26-year-old female, who presented with pallor, weight loss, jaundice, pancytopenia and hepatosplenomegaly. The bone marrow examination showed infiltration by lymphoid cells. These cells on flow cytometric evaluation showed the phenotype of hepatosplenic T cell lymphoma. The cells were positive for CD3, CD8, CD56 and TCR γδ and negative for CD5, CD4, CD8, CD16, CD57, TCRαβ along with B cell markers. This case is reported for being a rare clinical entity and its presence in an immunocompetent female making it rarer.
authors.affiliation: Associate Consultant, Department of Pathology and Lab Medicine, Medanta The Medicity , Gurgaon, Haryana, India .
authors.forename: Pranav
authors.initials: P
authors.lastname: Dorwal
authors.affiliation: Senior Consultant, Department of Pathology and Lab Medicine, Medanta The Medicity , Gurgaon, Haryana, India .
authors.forename: Ritesh
authors.initials: R
authors.lastname: Sachdev
authors.affiliation: Junior Scientist, Department of Pathology and Lab Medicine, Medanta The Medicity , Gurgaon, Haryana, India .
authors.forename: Amit
authors.initials: A
authors.lastname: Pande
authors.affiliation: Scientist, Department of Pathology and Lab Medicine, Medanta The Medicity , Gurgaon, Haryana, India .
authors.forename: Dharmendra
authors.initials: D
authors.lastname: Jain
authors.affiliation: Associate Consultant, Department of Pathology and Lab Medicine, Medanta The Medicity , Gurgaon, Haryana, India .
authors.forename: Bhawna
authors.initials: B
authors.lastname: Jha
authors.affiliation: Director, Department of Pathology and Lab Medicine, Medanta The Medicity , Gurgaon, Haryana, India .
authors.forename: Vimarsh
authors.initials: V
authors.lastname: Raina
keywords: Cluster of differentiation; Hepatosplenomegaly; Immunophenotyping; Pancytopenia