title: A new sensitivity-based adaptive control vector parameterization approach for dynamic optimization of bioprocesses.
abstract: Dynamic optimization is a very effective way to increase the profitability or productivity of bioprocesses. As an important method of dynamic optimization, the control vector parameterization (CVP) approach needs to select an optimal discretization level to balance the computational cost with the desired solution quality. A new sensitivity-based adaptive refinement method is therefore proposed, by which new time grid points are only inserted where necessary and unnecessary points are eliminated so as to obtain economic and effective discretization grids. Moreover, considering that traditional refinement methods may cost a lot to get the high-quality solutions of some bioprocess problems, whose performance indices are sensitive to some significant time points, an optimization technique is further proposed and embedded into the new sensitivity-based CVP approach to efficiently solve these problems. The proposed methods are applied to two well-known bioprocess optimization problems and the results illustrate their effectiveness.
authors.affiliation: College of Control Science and Engineering, Zhejiang University, Hangzhou, 310027, People's Republic of China.
authors.forename: Liwei
authors.initials: L
authors.lastname: Wang
authors.affiliation: College of Control Science and Engineering, Zhejiang University, Hangzhou, 310027, People's Republic of China. lxg@zjuem.zju.edu.cn.
authors.forename: Xinggao
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Mathematics, Zhejiang University, Hangzhou, 310027, People's Republic of China.
authors.forename: Zeyin
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D008954:Models, Biological
keywords: Adaptive grid refinement; Bioprocesses; Control vector parameterization; Dynamic optimization; Sensitivity