title: Removal of cephalosporin antibiotics 7-ACA from wastewater during the cultivation of lipid-accumulating microalgae.
abstract: The aim of this study is to evaluate the feasibility of using lipid-accumulating microalgae to remove cephalosporin antibiotics 7-amino cephalosporanic acid (7-ACA) from wastewater with the additional benefit of biofuels production. Three isolated microalgal strains (namely, Chlorella sp. Cha-01, Chlamydomonas sp. Tai-03 and Mychonastes sp. YL-02) were cultivated under 7-ACA stress and their biomass productivity, lipid production and N-NO3-consumption were monitored. It was found that 7-ACA had slight inhibition effects on the microalgal growth at the ratio of 12.0% (Cha-01), 9.6% (YL-02), 11.7% (Tai-03). However, lipid accumulation in the three microalgae was not influenced by the presence of 7-ACA. The investigation on the 7-ACA removal mechanisms during microalgal growth shows that 7-ACA was mainly removed by microalgae adsorption as well as hydrolysis and photolysis reactions. This study demonstrates that using microalgae to treat antibiotic-containing wastewater is promising due to the potential of simultaneous antibiotic removal and biofuel production.
authors.affiliation: State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, 73 Huanghe Road, Harbin, Heilongjiang 150090, PR China.
authors.forename: Wan-Qian
authors.initials: WQ
authors.lastname: Guo
authors.affiliation: State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, 73 Huanghe Road, Harbin, Heilongjiang 150090, PR China.
authors.forename: He-Shan
authors.initials: HS
authors.lastname: Zheng
authors.affiliation: State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, 73 Huanghe Road, Harbin, Heilongjiang 150090, PR China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Li
authors.affiliation: State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, 73 Huanghe Road, Harbin, Heilongjiang 150090, PR China.
authors.forename: Juan-Shan
authors.initials: JS
authors.lastname: Du
authors.affiliation: State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, 73 Huanghe Road, Harbin, Heilongjiang 150090, PR China.
authors.forename: Xiao-Chi
authors.initials: XC
authors.lastname: Feng
authors.affiliation: State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, 73 Huanghe Road, Harbin, Heilongjiang 150090, PR China.
authors.forename: Ren-Li
authors.initials: RL
authors.lastname: Yin
authors.affiliation: State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, 73 Huanghe Road, Harbin, Heilongjiang 150090, PR China.
authors.forename: Qing-Lian
authors.initials: QL
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, 73 Huanghe Road, Harbin, Heilongjiang 150090, PR China.
authors.forename: Nan-Qi
authors.initials: NQ
authors.lastname: Ren
authors.affiliation: State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, 73 Huanghe Road, Harbin, Heilongjiang 150090, PR China; Department of Chemical Engineering, National Cheng Kung University, Tainan 701, Taiwan; Research Center for Energy Technology and Strategy Center, National Cheng Kung University, Tainan 701, Taiwan. Electronic address: changjs@mail.ncku.edu.tw.
authors.forename: Jo-Shu
authors.initials: JS
authors.lastname: Chang
mesh_terms: D056804:Biofuels; D018533:Biomass; D002511:Cephalosporins / Q000302:isolation & purification*; D002696:Chlamydomonas / Q000254:growth & development / Q000378:metabolism; D002708:Chlorella / Q000254:growth & development / Q000378:metabolism; D008055:Lipids / Q000096:biosynthesis*; D058086:Microalgae / Q000254:growth & development* / Q000378:metabolism*; D062065:Wastewater / Q000737:chemistry*; D014874:Water Pollutants, Chemical / Q000302:isolation & purification; D018508:Water Purification / Q000379:methods
chemical_list: D056804:Biofuels; D002511:Cephalosporins; D008055:Lipids; D062065:Wastewater; D014874:Water Pollutants, Chemical
keywords: 7-ACA; Antibiotics-containing wastewater; Cephalosporins; Lipid production; Microalgae