title: T1 mapping in children and young adults with hypertrophic cardiomyopathy.
abstract: To assess the global and segmental left ventricular (LV) native T1 and extracellular volume fraction (ECV) in children and young adults with hypertrophic cardiomyopathy (HCM) compared to a control cohort. The study population included 21 HCM patients (mean 14.1 ± 4.6 years) and 21 controls (mean 15.7 ± 1.5 years). Native modified Look-Locker inversion recovery sequence was performed before and after contrast injection in 3 short axis planes. Global and segmental LV native T1 and ECV were quantified and compared between HCM patients and controls. Mean native T1 in HCM patients and controls was 1020.4 ± 41.2 and 965.6 ± 30.2 ms respectively (p < 0.0001). Hypertrophied myocardium had significantly higher native global T1 and global ECV compared to non-hypertrophied myocardium in HCM (p < 0.0001, = 0.14 and 0.048, = 0.01 respectively). In a subset of patients, ECV was higher in LV segments with LGE compared to no LGE (p < 0.0001). No significant correlation was identified between global native T1 and ECV and parameters of LV structure and function. Native T1 cut-off of 987 ms provided the highest sensitivity (95 %) and specificity (91 %) to separate HCM patients from controls. Global and segmental native T1 are elevated in HCM patients. LV segments with hypertrophy and/or LGE had higher ECV in a subset of HCM patients. LV native T1 and ECV do not correlate with parameters of LV structure and function. T1 in children and young adults may be used as a non-invasive tool to assess for HCM and related fibrosis.
authors.affiliation: Department of Medical Imaging, Ann and Robert H. Lurie Children's Hospital of Chicago, 225 East Chicago Avenue, Chicago, IL, 60611, USA. 23.keyurparekh@gmail.com.|Department of Radiology, Feinberg School of Medicine, Northwestern University, 225 East Chicago Avenue, Chicago, IL, 60611, USA. 23.keyurparekh@gmail.com.
authors.forename: Keyur
authors.initials: K
authors.lastname: Parekh
authors.affiliation: Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N Michigan Avenue, Chicago, IL, 60611, USA.|Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, 737 N Michigan Avenue, Chicago, IL, 60611, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Markl
authors.affiliation: Department of Medical Imaging, Ann and Robert H. Lurie Children's Hospital of Chicago, 225 East Chicago Avenue, Chicago, IL, 60611, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Deng
authors.affiliation: Department of Medical Imaging, Ann and Robert H. Lurie Children's Hospital of Chicago, 225 East Chicago Avenue, Chicago, IL, 60611, USA.|Division of Pediatric Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 East Chicago Avenue, Chicago, IL, 60611, USA.|Department of Pediatrics, Feinberg School of Medicine, Northwestern University, 225 East Chicago Avenue, Chicago, IL, 60611, USA.
authors.forename: Roger A
authors.initials: RA
authors.lastname: de Freitas
authors.affiliation: Department of Medical Imaging, Ann and Robert H. Lurie Children's Hospital of Chicago, 225 East Chicago Avenue, Chicago, IL, 60611, USA.|Department of Radiology, Feinberg School of Medicine, Northwestern University, 225 East Chicago Avenue, Chicago, IL, 60611, USA.
authors.forename: Cynthia K
authors.initials: CK
authors.lastname: Rigsby
mesh_terms: D000293:Adolescent; D019540:Area Under Curve; D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D005355:Fibrosis; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009206:Myocardium / Q000473:pathology; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D015203:Reproducibility of Results; D016277:Ventricular Function, Left; D055815:Young Adult
chemical_list: D003287:Contrast Media
keywords: Children; Hypertrophic cardiomyopathy; Magnetic resonance imaging; T1 mapping