title: Clinical Efficacy of Azithromycin as an Adjunctive Therapy to Non-Surgical Periodontal Treatment of Periodontitis: A Systematic Review and Meta-Analysis.
abstract: BACKGROUND
  Over the years, numerous trials have sufficiently documented benefits of adjuvant administration of antibiotics in combination to Scaling and Root Planing (SRP) in treatment of periodontitis. Nevertheless there are justified doubts in respect to antibiotics administration with regard to increasing development of resistances.
  
  
  OBJECTIVE
  The aim of this review study and meta-analysis was to verify a possible benefit of Azithromycin (AZM) as an alternative adjuvant antibiotic in combination with SRP.
  
  
  METHODS
  Electronic databases (Pubmed) were searched from the earliest point of record until May 2015. A hand search was also conducted. The variables considered in this respect were Probing Depth (PD), Clinical Attachment Level (CAL), Bleeding on Probing (BOP) and SRP. A meta-analysis containing trials comparing SRP as a sole therapy with SRP and administration of AZM was produced once all of the data obtained had been reviewed.
  
  
  RESULTS
  Six randomised clinical trials were accepted into the review and the meta-analysis following the process of trial selection. Meta-analysis revealed larger overall effects by the systemic administration of AZM compared with SRP on their own in terms of PD, CAL, BOP, Plaque-Index and total bacterial load reduction after three and six months.
  
  
  CONCLUSIONS
  The data used in this study revealed that the systemic administration of AZM is beneficial compared with SRP on its own for the treatment of chronic periodontitis.
authors.affiliation: Faculty, Department of Cariology, Endodontology and Periodontology, Centre for Periodontology, University Hospital of Leipzig , Leipzig, Germany .
authors.forename: Antonio
authors.initials: A
authors.lastname: Renatus
authors.affiliation: Student, Department of Cariology, Endodontology and Periodontology, Centre for Periodontology, University Hospital of Leipzig , Leipzig, Germany .
authors.forename: Jörg
authors.initials: J
authors.lastname: Herrmann
authors.affiliation: Student, Department of Psychology, Clinical Research Organization , Leipzig, Germany .
authors.forename: Antje
authors.initials: A
authors.lastname: Schönfelder
authors.affiliation: Professor, Faculty of Informatics/Mathematics, University of Applied Sciences , Dresden, Germany .
authors.forename: Fabian
authors.initials: F
authors.lastname: Schwarzenberger
authors.affiliation: Professor, Department of Cariology, Endodontology and Periodontology, Centre for Periodontology, University Hospital of Leipzig , Leipzig, Germany .
authors.forename: Holger
authors.initials: H
authors.lastname: Jentsch
keywords: Antibiotics; Drug therapy; Periodontal debridement