title: Complete Remission of Minimal Change Disease Following an Improvement of Lung Mycobacterium avium Infection.
abstract: A 46-year-old woman suddenly developed peripheral edema. Her massive proteinuria, hypoproteinemia, and renal biopsy findings yielded the diagnosis of minimal change disease (MCD). In addition, lung Mycobacterium avium infection was diagnosed according to a positive culture of her bronchoalveolar lavage fluid. The lung lesion was improved by anti-nontuberculous mycobacteria therapy. Surprisingly, her proteinuria also gradually decreased and she attained complete remission of MCD without any immunosuppressive therapy. She has subsequently remained in complete remission. We herein report an interesting case of MCD with lung Mycobacterium avium infection, suggesting a causal relationship among infection, immune system abnormality, and MCD/nephrotic syndrome.
authors.affiliation: Department of Nephrology and Endocrinology, National Defense Medical College, Japan.
authors.forename: Aoi
authors.initials: A
authors.lastname: Yamashiro
authors.forename: Takahiro
authors.initials: T
authors.lastname: Uchida
authors.forename: Seigo
authors.initials: S
authors.lastname: Ito
authors.forename: Naoki
authors.initials: N
authors.lastname: Oshima
authors.forename: Takashi
authors.initials: T
authors.lastname: Oda
authors.forename: Hiroo
authors.initials: H
authors.lastname: Kumagai
mesh_terms: D001706:Biopsy; D004487:Edema / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents; D007668:Kidney / Q000473:pathology*; D008875:Middle Aged; D009162:Mycobacterium avium / Q000302:isolation & purification*; D015270:Mycobacterium avium-intracellulare Infection / Q000473:pathology*; D009402:Nephrosis, Lipoid / Q000150:complications / Q000473:pathology*; D011507:Proteinuria / Q000209:etiology / Q000473:pathology*; D012074:Remission Induction; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents