title: Association of swine leukocyte antigen class II haplotypes and immune-related traits in a swine line selected for resistance to mycoplasmal pneumonia.
abstract: By selective breeding for five generations, a Landrace line has been recently established to improve resistance to mycoplasmal pneumonia of swine (MPS), daily gain (DG), back fat thickness (BF), and plasma cortisol concentrations (COR). To clarify the involvement of swine leukocyte antigen (SLA) polymorphisms in the selection process, we investigated possible associations of 11 SLA-class II haplotypes with selected traits or immune parameters. Pigs with the low-resolution SLA haplotype Lr-0.23 or Lr-0.13, which increased in frequency with the passage of generations, had less severe pathological lesions of MPS, increased leukocyte phagocytic activity, and higher white blood cell counts. In contrast, Lr-0.12 and Lr-0.2, which decreased in subsequent generations, were weakly associated with more severe pathological lesions of MPS. Therefore, in the studied Landrace line, the Lr-0.23 and Lr-0.13 haplotypes are potentially useful genetic markers for selecting and breeding animals with less severe pathological lesions of MPS.
authors.affiliation: Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
authors.forename: Asako
authors.initials: A
authors.lastname: Ando
authors.affiliation: Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Shigenari
authors.affiliation: Miyagi Livestock Experimental Station, 1 Hiwatashi, Minamisawa, Iwadeyama, Osaki, Miyagi 989-6445, Japan.
authors.forename: Chihiro
authors.initials: C
authors.lastname: Kojima-Shibata
authors.affiliation: Miyagi Livestock Experimental Station, 1 Hiwatashi, Minamisawa, Iwadeyama, Osaki, Miyagi 989-6445, Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Nakajoh
authors.affiliation: Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Aoba-ku, Sendai, Miyagi 981-8555, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Suzuki
authors.affiliation: Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, Gifu 501-1193, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kitagawa
authors.affiliation: Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Shiina
authors.affiliation: Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Inoko
authors.affiliation: Division of Animal Sciences, Institute of Agrobiological Sciences, National Agriculture and Food Research Organization, 1-2 Owashi, Tsukuba, Ibaraki 305-8634, Japan. Electronic address: huenishi@affrc.go.jp.
authors.forename: Hirohide
authors.initials: H
authors.lastname: Uenishi
mesh_terms: D000818:Animals; D001947:Breeding; D060467:Disease Resistance / Q000235:genetics; D005819:Genetic Markers; D005838:Genotype; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000276:immunology*; D006854:Hydrocortisone / Q000097:blood; D007958:Leukocyte Count; D010587:Phagocytosis; D010641:Phenotype; D045729:Pneumonia of Swine, Mycoplasmal / Q000235:genetics* / Q000276:immunology* / Q000382:microbiology / Q000503:physiopathology; D011110:Polymorphism, Genetic; D013552:Swine / Q000276:immunology*
chemical_list: D005819:Genetic Markers; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; C438668:swine leukocyte antigen; D006854:Hydrocortisone
keywords: Disease association; Genotype; Haplotype; Mycoplasmal pneumonia; Swine leukocyte antigen