title: Expression of nephronectin is enhanced by 1α,25-dihydroxyvitamin D3.
abstract: The extracellular matrix protein nephronectin (Npnt), also called POEM, is considered to play critical roles as an adhesion molecule in development and functions of various tissues, such as the kidneys, liver, and bone. In the present study, we examined the molecular mechanism of Npnt gene expression and found that vitamin D3 (1α,25-dihydroxyvitamin D3,VD 3) strongly enhanced Npnt mRNA expression in MC3T3-E1 cells from a mouse osteoblastic cell line. The VD 3-induced increase in Npnt expression is both time- and dose-dependent and is mediated by the vitamin D receptor (VDR).
authors.affiliation: Department of Biochemistry School of Dentistry Showa University Tokyo Japan; Department of Perioperative Medicine Division of Anesthesiology School of Dentistry Showa University Tokyo Japan.
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Hiranuma
authors.affiliation: Department of Biochemistry School of Dentistry Showa University Tokyo Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yamada
authors.affiliation: Department of Biochemistry School of Dentistry Showa University Tokyo Japan.
authors.forename: Tamaki
authors.initials: T
authors.lastname: Kurosawa
authors.affiliation: Department of Biochemistry School of Dentistry Showa University Tokyo Japan; Department of Periodontology School of Dentistry Showa University Tokyo Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Aizawa
authors.affiliation: Department of Biochemistry School of Dentistry Showa University Tokyo Japan.
authors.forename: Dai
authors.initials: D
authors.lastname: Suzuki
authors.affiliation: Department of Biochemistry School of Dentistry Showa University Tokyo Japan; Department of Oral and Maxillofacial Surgery School of Dentistry Showa University Tokyo Japan.
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Saito
authors.affiliation: Department of Biochemistry School of Dentistry Showa University Tokyo Japan; Department of Orthodontics School of Dentistry Showa University Tokyo Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Nagahama
authors.affiliation: Department of Biochemistry School of Dentistry Showa University Tokyo Japan; Department of Oral and Maxillofacial Surgery Tokyo Medical University Japan.
authors.forename: Mikiko
authors.initials: M
authors.lastname: Ikehata
authors.affiliation: Department of Biochemistry School of Dentistry Showa University Tokyo Japan; Present address: Department of Immunology Graduate School of Medicine and Faculty of Medicine The University of Tokyo Hongo 7-3-1, Bunkyo-ku Tokyo 113-0033 Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Tsukasaki
authors.affiliation: Brain Science Laboratory The Research Organization of Science and Technology Ritsumeikan University Kusatsu Shiga Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Morimura
authors.affiliation: Department of Oral and Maxillofacial Surgery Tokyo Medical University Japan.
authors.forename: Daichi
authors.initials: D
authors.lastname: Chikazu
authors.affiliation: Department of Orthodontics School of Dentistry Showa University Tokyo Japan.
authors.forename: Koutaro
authors.initials: K
authors.lastname: Maki
authors.affiliation: Department of Oral and Maxillofacial Surgery School of Dentistry Showa University Tokyo Japan.
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Shirota
authors.affiliation: Department of Pharmacology School of Dentistry Showa University Tokyo Japan.
authors.forename: Masamichi
authors.initials: M
authors.lastname: Takami
authors.affiliation: Department of Periodontology School of Dentistry Showa University Tokyo Japan.
authors.forename: Matsuo
authors.initials: M
authors.lastname: Yamamoto
authors.affiliation: Department of Perioperative Medicine Division of Anesthesiology School of Dentistry Showa University Tokyo Japan.
authors.forename: Takehiko
authors.initials: T
authors.lastname: Iijima
authors.affiliation: Department of Biochemistry School of Dentistry Showa University Tokyo Japan.
authors.forename: Ryutaro
authors.initials: R
authors.lastname: Kamijo
keywords: 1α,25‐dihydroxyvitamin D3; nephronectin; vitamin D receptor