title: Effect of perinatal glucocorticoids on vascular health and disease.
abstract: The benefits of antenatal glucocorticoids are now firmly established in the perinatal management of threatened preterm birth. Postnatal glucocorticoid therapy, however, remains controversial in neonatal medicine, with the need to balance short-term physiological benefits against the potential for long-term adverse consequences. This review focuses on the vascular effects of prenatal and postnatal glucocorticoids, synthesizing data from both experimental animal models and human infants with the goal of better appreciation of the short and long-term effects of these commonly used drugs. Due to their widespread and varied use, improved understanding of the cellular and molecular impact of glucocorticoids is important in guiding current practice and future research.
authors.affiliation: Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee.
authors.forename: Aaron R
authors.initials: AR
authors.lastname: Millage
authors.affiliation: Department of Pediatrics, Albert Einstein College of Medicine and the Children's Hospital at Montefiore, Bronx, New York.
authors.forename: Mariam S
authors.initials: MS
authors.lastname: Latuga
authors.affiliation: Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee.|Department of Pediatrics, Albert Einstein College of Medicine and the Children's Hospital at Montefiore, Bronx, New York.
authors.forename: Judy L
authors.initials: JL
authors.lastname: Aschner
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001808:Blood Vessels / Q000187:drug effects* / Q000502:physiology; D005260:Female; D005325:Fetal Organ Maturity / Q000187:drug effects / Q000502:physiology; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000187:drug effects / Q000196:embryology / Q000502:physiology; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D018743:Perinatal Care; D011247:Pregnancy; D011652:Pulmonary Circulation / Q000187:drug effects / Q000502:physiology
chemical_list: D005938:Glucocorticoids; D052250:Nitric Oxide Synthase Type III