title: [Prevalence of Elevated Lipoprotein (a) Levels in Patients < 60 Years of Age with Retinal Vein Occlusion].
abstract: BACKGROUND
  The potential impact of elevated Lipoprotein (a) [Lp(a)] levels on retinal venous occlusive (RVO) diseases with regard to age and various risk factors has not been studied extensively.
  
  
  METHODS
  In a retrospective case-control study, thrombophilia data of 106 young patients (< 60 years at the time of the RVO or a previous thromboembolic event) with RVO and 76 healthy subjects were evaluated.
  
  
  RESULTS
  Elevated Lp(a) plasma levels were significantly more prevalent among RVO patients (29.2 %) than among controls (9.2 %; p = 0.0009). Lp(a) levels were found to be significantly (p = 0.012) different between patients and controls. Moreover, we found that an unusual personal or family history of thromboembolism was a strong predictor of elevated Lp(a) (p = 0.03). We observed a significant correlation between elevated Lp(a) and other coagulation disorders (p = 0.005). Multivariate analysis showed that elevated lipoprotein(a) levels (OR: 3.5; p = 0.003) were an independent risk factor for the development of RVO.
  
  
  CONCLUSIONS
  Elevated plasma levels of Lp(a) are associated with the development of RVO. Selective screening of young patients and subjects with a personal or family history of thromboembolism may be helpful in identifying RVO patients with elevated Lp(a).
authors.affiliation: Klinik für Augenheilkunde, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt.
authors.forename: C
authors.initials: C
authors.lastname: Kuhli-Hattenbach
authors.affiliation: Institut für Hämostaseologie und Transfusionsmedizin, Klinikum der Stadt Ludwigshafen gGmbH.
authors.forename: P
authors.initials: P
authors.lastname: Hellstern
authors.affiliation: Medizinische Klinik II/Institut für Transfusionsmedizin und Immunhämatologie, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt.
authors.forename: W
authors.initials: W
authors.lastname: Miesbach
authors.affiliation: Klinik für Augenheilkunde, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt.
authors.forename: T
authors.initials: T
authors.lastname: Kohnen
authors.affiliation: Augenklinik, Klinikum der Stadt Ludwigshafen gGmbH.
authors.forename: L-O
authors.initials: LO
authors.lastname: Hattenbach
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012170:Retinal Vein Occlusion / Q000097:blood* / Q000235:genetics; D012189:Retrospective Studies; D012307:Risk Factors; D013923:Thromboembolism / Q000097:blood / Q000235:genetics; D019851:Thrombophilia / Q000097:blood / Q000235:genetics
chemical_list: D017270:Lipoprotein(a)