title: Aspernolides L and M, new butyrolactones from the endophytic fungus Aspergillus versicolor.
abstract: During the systematic search of active compounds from endophytic fungi, two new butyrolactones, namely aspernolides L (2) and M (4), together with four known compounds: 1-O-acetylglycerol (1), butyrolactone I (3), butyrolactone VI (5), and (+) alantrypinone (6) were characterized from the EtOAc extract of the endophytic fungus Aspergillus versicolor isolated from the roots of Pulicaria crispa (Asteraceae). Extensive spectroscopic analysis, including 1D, 2D NMR, and HRESIMS, was used to elucidate their structures. Compounds 1, 5, and 6 are reported for the first time from this fungus.
authors.affiliation: Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al Madinah Al Munawwarah 30078, Saudi Arabia, Phone: +966 581183034, E-mail: sribrahim@taibahu.edu.sa.|Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
authors.forename: Sabrin R M
authors.initials: SRM
authors.lastname: Ibrahim
authors.affiliation: Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.|Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.
authors.forename: Gamal A
authors.initials: GA
authors.lastname: Mohamed
authors.affiliation: National Center for Natural Products Research, Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, Mississippi 38677, United States of America.
authors.forename: Samir A
authors.initials: SA
authors.lastname: Ross
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000302:isolation & purification*; D001230:Aspergillus / Q000737:chemistry*; D000431:Ethanol / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018517:Plant Roots / Q000382:microbiology; D052587:Pulicaria / Q000382:microbiology*; D012997:Solvents / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D012997:Solvents; D000431:Ethanol; D015107:4-Butyrolactone
keywords: Aspergillus versicolor; Aspernolide; Pulicaria crispa; butyrolactones; endophytic fungi