title: Evaluation of Cerebral Oxygenation in Neonates with Sepsis with Near-Infrared Spectroscopy.
abstract: ObjectiveNeonates with sepsis have increased risk of cerebral injury. Our aim was to evaluate cerebral oxygenation in septic neonates using near-infrared spectroscopy.Study DesignA prospective study was designed enrolling neonates with sepsis, as defined by the International Consensus Conference of Pediatric Sepsis criteria and matched controls. Three cerebral half-hourly measurements were performed during the first, third, and seventh day of the episode and the values of tissue oxygenation index (TOI) and fractional tissue oxygen extraction (FTOE) were compared between the two groups.ResultThe study population consisted of 50 septic and 44 control neonates with similar characteristics. No differences on TOI and FTOE were recorded in the first and third day. However, on the seventh day, septic neonates had significantly decreased oxygenation (62.7 ± 7 vs. 71.4 ± 4.4%,p< 0.001) and increased oxygen extraction (0.35 ± 0.07 vs. 0.27 ± 0.05,p< 0.001), irrespectively of the severity of the infection.ConclusionAlthough septic neonates have normal cerebral oxygenation in the first and third day of the sepsis, they present decreased cerebral oxygenation in the seventh day independently of the infection severity.
authors.affiliation: 2nd NICU and Neonatology Department, General Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Rallis
authors.affiliation: 2nd NICU and Neonatology Department, General Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Paraskevi
authors.initials: P
authors.lastname: Karagianni
authors.affiliation: 2nd NICU and Neonatology Department, General Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Eleni
authors.initials: E
authors.lastname: Milona
authors.affiliation: 2nd NICU and Neonatology Department, General Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Paraskevi
authors.initials: P
authors.lastname: Pratsiou
authors.affiliation: 2nd NICU and Neonatology Department, General Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Nikolaidis
authors.affiliation: 2nd NICU and Neonatology Department, General Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Christos
authors.initials: C
authors.lastname: Tsakalidis
mesh_terms: D016022:Case-Control Studies; D054022:Cerebrum / Q000378:metabolism*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D011446:Prospective Studies; D018805:Sepsis / Q000503:physiopathology*; D012720:Severity of Illness Index; D012772:Shock, Septic / Q000503:physiopathology; D019265:Spectroscopy, Near-Infrared; D013997:Time Factors
chemical_list: D010100:Oxygen