title: Factors affecting clinical pregnancy rates after IUI for the treatment of unexplained infertility and mild male subfertility.
abstract: OBJECTIVE
  The aim of the present retrospective study was to evaluate intrauterine insemination (IUI) clinical experiences and to define the variables for predicting success.
  
  
  METHODS
  The present study was an observational trial performed in a private IVF center on subfertile couples who had applied for treatment between 2002 and 2012, in which the data of 503 IUI cases were retrospectively reviewed. Couples who had been diagnosed with unexplained and mild male subfertility were included. The primary outcome measure was the clinical pregnancy rate in an attempt to form a predictive model for the odds of a clinical pregnancy. Recorded parameters were used to determine the prediction model.
  
  
  RESULTS
  Utilizing univariate logistic regression analysis, clinical pregnancy was positively associated with the duration of infertility (OR=1.09, p=0.089), secondary infertility (OR=1.77, p=0.050), and +4 sperm motility after preparation (OR=1.03, p=0.091). Following an adjustment analysis involving a multivariate logistic regression, clinical pregnancy was still found to positively associate with secondary infertility (OR=2.51, p=0.008).
  
  
  CONCLUSIONS
  IUI success in secondary infertile couples who were in the unexplained infertility and mild male subfertility groups was higher than that in primary infertile couples, and the chances of pregnancy increased as sperm numbers with +4 motility increased. It is difficult to concomitantly evaluate all these parameters and to determine a predictive parameter in IUI independent from other factors.
authors.affiliation: Department of Obstetrics and Gynecology, Giresun University School of Medicine, Giresun, Turkey.
authors.forename: Melahat
authors.initials: M
authors.lastname: Atasever
authors.affiliation: Department of Obstetrics and Gynecology, Turgut Özal University School of Medicine, Ankara, Turkey.
authors.forename: Müberra Namlı
authors.initials: MN
authors.lastname: Kalem
authors.affiliation: Clinart IVF Center, Giresun, Turkey.
authors.forename: Şafak
authors.initials: Ş
authors.lastname: Hatırnaz
authors.affiliation: Clinart IVF Center, Giresun, Turkey.
authors.forename: Ebru
authors.initials: E
authors.lastname: Hatırnaz
authors.affiliation: Gürgan Clinic IVF Center, Ankara, Turkey.
authors.forename: Ziya
authors.initials: Z
authors.lastname: Kalem
authors.affiliation: Department of Statistics, Middle East Technical University, Ankara, Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Kalaylıoğlu
keywords: Intrauterine insemination; male subfertility; unexplained infertility