title: Marginal zone dural lymphoma: the Memorial Sloan Kettering Cancer Center and University of Miami experiences.
abstract: Dural lymphoma (DL) is a rare type of primary CNS lymphoma arising from the dura mater. The optimal treatment is uncertain. A retrospective review was performed on 26 DL patients. Seventeen patients underwent resection and nine had a biopsy. Twenty three patients could be assessed for a response to treatment after surgery. Thirteen received focal radiotherapy (RT), six whole brain RT (WBRT), three chemotherapy alone and one chemotherapy followed by WBRT. Twenty two achieved complete response (CR) and one a partial response (PR). Four patients relapsed (two local and two systemic). Median follow up was 64 months, with median progression free survival (PFS) and OS not reached. Three year PFS was 89% (95% CI 0.64-0.97). All patients are alive at last follow-up, demonstrating that DL is an indolent tumor with long survival. CR is achievable with focal therapy in the majority of cases, but there is a risk for relapses and long-term follow-up is recommended.
authors.affiliation: a Departments of Neurology and Sylvester Comprehensive Cancer Center , University of Miami , Miami , FL , USA.
authors.forename: Macarena I
authors.initials: MI
authors.lastname: de la Fuente
authors.affiliation: b Department of Neurology , Memorial Sloan Kettering Cancer Center , New York , NY , USA.
authors.forename: Aya
authors.initials: A
authors.lastname: Haggiagi
authors.affiliation: c Department of Hematopathology, Pathology and Laboratory Medicine , University of Miami/Sylvester Comprehensive Cancer Center , Miami , FL , USA.|g Division of Hematology-Oncology, Department of Medicine , Sylvester Comprehensive Cancer Center, University of Miami , Miami , FL , USA.
authors.forename: Adrienne
authors.initials: A
authors.lastname: Moul
authors.affiliation: d Department of Radiology , Memorial Sloan Kettering Cancer Center , New York , NY , USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Young
authors.affiliation: e Department of Radiology , University of Miami , Miami , FL , USA.
authors.forename: Charif
authors.initials: C
authors.lastname: Sidani
authors.affiliation: f Department of Radiation Oncology , University of Miami , FL , USA.
authors.forename: Arnold
authors.initials: A
authors.lastname: Markoe
authors.affiliation: c Department of Hematopathology, Pathology and Laboratory Medicine , University of Miami/Sylvester Comprehensive Cancer Center , Miami , FL , USA.
authors.forename: Francisco
authors.initials: F
authors.lastname: Vega
authors.affiliation: b Department of Neurology , Memorial Sloan Kettering Cancer Center , New York , NY , USA.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: DeAngelis
authors.affiliation: g Division of Hematology-Oncology, Department of Medicine , Sylvester Comprehensive Cancer Center, University of Miami , Miami , FL , USA.|h Department of Molecular and Cellular Pharmacology , Sylvester Comprehensive Cancer Center, University of Miami , Miami , FL , USA.
authors.forename: Izidore S
authors.initials: IS
authors.lastname: Lossos
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001706:Biopsy; D001921:Brain / Q000473:pathology; D016543:Central Nervous System Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*; D004388:Dura Mater / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
keywords: Dural lymphoma; focal radiotherapy; marginal zone lymphoma; primary central nervous system lymphoma