title: [Research progress of the application of probiotics in preterm infants].
abstract: The gastrointestinal structure, function and immunity of preterm infants are immature. Furthermore the gastrointestinal microbe colonization is abnormal. Therefore the preterm infants are prone to a variety of gastrointestinal diseases. Probiotics can regulate gastrointestinal microbe constitute, improve gastrointestinal barrier function, reduce gastrointestinal inflammation response and regulate the immunity. At present, it is used for the prevention of necrotizing enterocolitis, late-onset sepsis, and feeding intolerance. The safety and efficacy of probiotics for preterm infants are still controversial.
authors.affiliation: Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang 110004, China. lijuan@sj-hospital.org.
authors.forename: Xin
authors.initials: X
authors.lastname: Gan
authors.forename: Juan
authors.initials: J
authors.lastname: Li
mesh_terms: D017209:Apoptosis; D020345:Enterocolitis, Necrotizing / Q000517:prevention & control; D041981:Gastrointestinal Tract / Q000276:immunology / Q000382:microbiology; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000517:prevention & control*; D000072742:Invasive Fungal Infections / Q000517:prevention & control; D000071074:Neonatal Sepsis / Q000517:prevention & control; D019936:Probiotics / Q000009:adverse effects / Q000627:therapeutic use*