title: Identification of a new sildenafil analogue adulterant, desethylcarbodenafil, in a herbal supplement.
abstract: In a maca-containing herbal supplement claimed to remedy erectile dysfunction, a new sildenafil analogue was found using adulterant screening with TLC, GC-MS and LC-MS/MS. This compound was isolated by column chromatography and HPLC, and identified by extensive 1D- and 2D-NMR and mass spectral analyses. The structure of this new compound was established as 5-[2-ethoxy-5-(piperazine-1-carbonyl) phenyl]-1-methyl-3-propyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one, and was named desethylcarbodenafil.
authors.affiliation: a Chemical Lab , Super Laboratory Company Ltd , New Taipei , Taiwan (R.O.C.).
authors.forename: Yen-Chun
authors.initials: YC
authors.lastname: Huang
authors.affiliation: b Division of Research and Analysis , Taiwan Food and Drug Administration , Taipei , Taiwan (R.O.C.).
authors.forename: Hui-Chun
authors.initials: HC
authors.lastname: Lee
authors.affiliation: c Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources , China Medical University , Taichung , Taiwan (R.O.C.).
authors.forename: Yun-Lian
authors.initials: YL
authors.lastname: Lin
authors.affiliation: b Division of Research and Analysis , Taiwan Food and Drug Administration , Taipei , Taiwan (R.O.C.).
authors.forename: Ya-Tze
authors.initials: YT
authors.lastname: Lin
authors.affiliation: b Division of Research and Analysis , Taiwan Food and Drug Administration , Taipei , Taiwan (R.O.C.).
authors.forename: Chia-Fen
authors.initials: CF
authors.lastname: Tsai
authors.affiliation: b Division of Research and Analysis , Taiwan Food and Drug Administration , Taipei , Taiwan (R.O.C.).
authors.forename: Hwei-Fang
authors.initials: HF
authors.lastname: Cheng
mesh_terms: D019587:Dietary Supplements / Q000032:analysis*; D004340:Drug Contamination; D015394:Molecular Structure; D000068677:Sildenafil Citrate / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry
chemical_list: C000617016:desethylcarbodenafil; D000068677:Sildenafil Citrate
keywords: Sildenafil analogue; adulterated food supplements; desethylcarbodenafil