title: Mucinous carcinoma of the thyroid: A case report and review of the literature.
abstract: We report the case of a primary mucinous carcinoma of the thyroid in a man of 74 who had a 4-cm nodule in the right lobe of the thyroid, with a solido-cystic appearance on ultrasound associated with lymph node metastases. On scintigraphy, the nodule was hot and not extinctive. The patient underwent total thyroidectomy with a ipsilateral right lymph node dissection. The immunohistochemical study showed the negativity of CK 7 and CK 20 and the positivity of thyroglobulin and TTF 1. Postoperatively the rate of blood thyroglobulin 3 months after surgery had collapsed to 0.17ng/ml. The evolution was marked by the appearance of pulmonary metastasis and the patient died 4 months after surgery. Histological study showed the presence of almas of neoplastic cells surrounded by large deposits of extracellular mucin. Primitive mucinous carcinoma of the thyroid is a rare tumor which differential diagnosis is established on the positive immunohistochemistry of thyroglobulin and TTF1 but negative for other markers.
authors.affiliation: Service d'ORL et chirurgie cervico-facial, université Hassan II, hôpital 20 Août 1953, Casablanca, Morocco. Electronic address: m.y.bajja@gmail.com.
authors.forename: Mohamed Yahya
authors.initials: MY
authors.lastname: Bajja
authors.affiliation: Service d'endocrinologie, université Hassan II, CHU Ibn Rochd, Casablanca, Morocco. Electronic address: fzahra.ben@hotmail.fr.
authors.forename: Fatima Zahra
authors.initials: FZ
authors.lastname: Benassila
authors.affiliation: Service d'ORL et chirurgie cervico-facial, université Hassan II, hôpital 20 Août 1953, Casablanca, Morocco.
authors.forename: Radallah Larbi
authors.initials: RL
authors.lastname: Abada
authors.affiliation: Service d'ORL et chirurgie cervico-facial, université Hassan II, hôpital 20 Août 1953, Casablanca, Morocco.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Mahtar
authors.affiliation: Service d'endocrinologie, université Hassan II, CHU Ibn Rochd, Casablanca, Morocco. Electronic address: drachadli@gmail.com.
authors.forename: Asma
authors.initials: A
authors.lastname: Chadli
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D000368:Aged; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D013954:Thyroglobulin / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D013965:Thyroidectomy
chemical_list: D013954:Thyroglobulin
keywords: Cancer thyroïde; Carcinome mucineux; Mucin; Mucine; Mucinous carcinoma; TTF1; Thyroid cancer