title: Novel Form of Curcumin Improves Endothelial Function in Young, Healthy Individuals: A Double-Blind Placebo Controlled Study.
abstract: Curcumin, a turmeric extract, may protect against cardiovascular diseases by enhancing endothelial function. In this randomized controlled double-blind parallel prospective study, fifty-nine healthy adults were assigned to placebo, 50 mg (50 mg), or 200 mg (200 mg) curcumin, for 8 weeks. The higher curcumin (200 mg) supplementation produced a dose-mediated improvement in endothelial function measured by flow-mediated dilation (FMD). The outcome was a clinically substantial 3.0% increase (90% CI 0.7 to 5.3%, p = 0.032; benefit : harm odds ratio 546 : 1) with the 200 mg dose, relative to placebo. The 50 mg dose also increased FMD relative to placebo by 1.7% (-0.6 to 4.0%, p = 0.23; 25 : 1), but the outcome was not clinically decisive. In apparently healthy adults, 8 weeks of 200 mg oral curcumin supplementation resulted in a clinically meaningful improvement in endothelial function as measured by FMD. Oral curcumin supplementation may present a simple lifestyle strategy for decreasing the risk of cardiovascular diseases. This trial was registered at ISRCTN registry (ISRCTN90184217).
authors.affiliation: Department of Kinesiology, Texas Christian University, TCU Box 297730, Fort Worth, TX 76129, USA.
authors.forename: Jonathan M
authors.identifier: 0000-0002-2505-1977
authors.initials: JM
authors.lastname: Oliver
authors.affiliation: School of Sport and Exercise, Massey University, 63 Wallace Street, Wellington 6021, New Zealand.
authors.forename: Lee
authors.initials: L
authors.lastname: Stoner
authors.affiliation: School of Sport and Exercise, Massey University, 63 Wallace Street, Wellington 6021, New Zealand.
authors.forename: David S
authors.initials: DS
authors.lastname: Rowlands
authors.affiliation: Department of Kinesiology, Texas Christian University, TCU Box 297730, Fort Worth, TX 76129, USA.
authors.forename: Aaron R
authors.initials: AR
authors.lastname: Caldwell
authors.affiliation: Department of Kinesiology, Texas Christian University, TCU Box 297730, Fort Worth, TX 76129, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Sanders
authors.affiliation: Department of Kinesiology, Texas Christian University, TCU Box 297730, Fort Worth, TX 76129, USA.
authors.forename: Andreas
authors.initials: A
authors.lastname: Kreutzer
authors.affiliation: Department of Kinesiology, Texas Christian University, TCU Box 297730, Fort Worth, TX 76129, USA.
authors.forename: Joel B
authors.initials: JB
authors.lastname: Mitchell
authors.affiliation: Increnovo LLC, 2138 E. Lafayette Place, Milwaukee, WI 53202, USA.
authors.forename: Martin
authors.initials: M
authors.lastname: Purpura
authors.affiliation: Increnovo LLC, 2138 E. Lafayette Place, Milwaukee, WI 53202, USA.
authors.forename: Ralf
authors.initials: R
authors.lastname: Jäger