title: Prognostic significance of low microRNA-218 expression in patients with different types of cancer: Evidence from published studies.
abstract: BACKGROUND
  Mounting evidence showed that microRNAs may be useful as prognostic biomarkers of cancer. Therefore, we summarize the predictive role of microRNA-218 (miR-218) for survival in patients with various cancers.
  
  
  METHODS
  We performed a systematic literature review and assessed the quality of included studies based on Meta-analysis of Observational Studies in Epidemiology group (MOOSE). Hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) were calculated to assess the correlation between miR-218 expression and prognosis of different cancers.
  
  
  RESULTS
  We identified 10 studies for pooled analyses. For overall survival, a lower expression levels of miR-218 significantly predicted poorer survival, with the pooled HR of 2.61 (95% CI: 2.11-3.22, P < 0.001). For disease-free survival/progressive-free survival/recurrence-free survival (DFS/PFS/RFS), a lower expression level of miR-218 significantly predicted worse DFS/PFS/RFS in various carcinomas, with the pooled HR of 2.73 (95% CI: 2.08-3.58, P < 0.001). Similarly, subgroup analysis by detection method, ethnicity and cancer subtype analysis suggested that lower expression of miR-218 correlated with.
  
  
  CONCLUSIONS
  Our data demonstrated that lower miR-218 expression is significantly associated with poorer overall survival (OS) and DFS/PFS/RFS and may be a novel prognostic biomarker in some cancer types.
authors.affiliation: Department of Hospital Infection Management Department of Ultrasound, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan, China Department of Epidemiology, College of Public Health, Zhengzhou University Department of Nosocomial Infection Management, The First Affiliated Hospital of Zhengzhou University Henan Key Laboratory of Tumor Epidemiology, Zhengzhou, Henan, China College of Professional Study, Northeastern University, Boston, MA.
authors.forename: Fujiao
authors.initials: F
authors.lastname: Duan
authors.forename: Kaijuan
authors.initials: K
authors.lastname: Wang
authors.forename: Liping
authors.initials: L
authors.lastname: Dai
authors.forename: Xia
authors.initials: X
authors.lastname: Zhao
authors.forename: Yajing
authors.initials: Y
authors.lastname: Feng
authors.forename: Chunhua
authors.initials: C
authors.lastname: Song
authors.forename: Shuli
authors.initials: S
authors.lastname: Cui
authors.forename: Chengzeng
authors.initials: C
authors.lastname: Wang
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D009369:Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; C547471:MIRN218 microRNA, human; D035683:MicroRNAs