title: Cell biology, physiology and enzymology of phosphatidylserine decarboxylase.
abstract: Phosphatidylethanolamine is one of the most abundant phospholipids whose major amounts are formed by phosphatidylserine decarboxylases (PSD). Here we provide a comprehensive description of different types of PSDs in the different kingdoms of life. In eukaryotes, type I PSDs are mitochondrial enzymes, whereas other PSDs are localized to other cellular compartments. We describe the role of mitochondrial Psd1 proteins, their function, enzymology, biogenesis, assembly into mitochondria and their contribution to phospholipid homeostasis in much detail. We also discuss briefly the cellular physiology and the enzymology of Psd2. This article is part of a Special Issue entitled: Lipids of Mitochondria edited by Guenther Daum.
authors.affiliation: Institute of Biochemistry, Graz University of Technology, Petersgasse 12/2, A-8010 Graz, Austria.
authors.forename: Francesca
authors.initials: F
authors.lastname: Di Bartolomeo
authors.affiliation: Institute of Biochemistry, Graz University of Technology, Petersgasse 12/2, A-8010 Graz, Austria.
authors.forename: Ariane
authors.initials: A
authors.lastname: Wagner
authors.affiliation: Institute of Biochemistry, Graz University of Technology, Petersgasse 12/2, A-8010 Graz, Austria. Electronic address: guenther.daum@tugraz.at.
authors.forename: Günther
authors.initials: G
authors.lastname: Daum
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002262:Carboxy-Lyases / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000378:metabolism; D010714:Phosphatidylethanolamines / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism
chemical_list: D024101:Mitochondrial Proteins; D010714:Phosphatidylethanolamines; D010743:Phospholipids; C483858:phosphatidylethanolamine; D002262:Carboxy-Lyases; C022353:phosphatidylserine decarboxylase
keywords: Lipids; Mitochondria; Phosphatidylethanolamine; Phosphatidylserine decarboxylase