title: Feasibility of FDG-PET in myocarditis: Comparison to CMR using integrated PET/MRI.
abstract: Besides cardiac sarcoidosis, FDG-PET is rarely used in the diagnosis of myocardial inflammation, while cardiac MRI (CMR) is the actual imaging reference for the workup of myocarditis. Using integrated PET/MRI in patients with suspected myocarditis, we prospectively compared FDG-PET to CMR and the feasibility of integrated FDG-PET/MRI in myocarditis.
  
  
  
  A total of 65 consecutive patients with suspected myocarditis were prospectively assessed using integrated cardiac FDG-PET/MRI. Studies comprised T2-weighted imaging, late gadolinium enhancement (LGE), and simultaneous PET acquisition. Physiological glucose uptake in the myocardium was suppressed using dietary preparation.
  
  
  
  FDG-PET/MRI was successful in 55 of 65 enrolled patients: two patients were excluded due to claustrophobia and eight patients due to failed inhibition of myocardial glucose uptake. Compared with CMR (LGE and/or T2), sensitivity and specificity of PET was 74% and 97%. Overall spatial agreement between PET and CMR was κ = 0.73. Spatial agreement between PET and T2 (κ = 0.75) was higher than agreement between PET and LGE (κ = 0.64) as well as between LGE and T2 (κ = 0.56).
  
  
  
  In patients with suspected myocarditis, FDG-PET is in good agreement with CMR findings.
authors.affiliation: Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45147, Essen, Germany. felix.nensa@uk-essen.de.
authors.forename: Felix
authors.initials: F
authors.lastname: Nensa
authors.affiliation: Clinic for Cardiology, University Hospital Essen, University of Duisburg-Essen, 45147, Essen, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Kloth
authors.affiliation: Clinic for Cardiology, University Hospital Essen, University of Duisburg-Essen, 45147, Essen, Germany.
authors.forename: Ercan
authors.initials: E
authors.lastname: Tezgah
authors.affiliation: Clinic for Nuclear Medicine, University Hospital Essen, University of Duisburg-Essen, 45147, Essen, Germany.
authors.forename: Thorsten D
authors.initials: TD
authors.lastname: Poeppel
authors.affiliation: Department of Diagnostic and Interventional Radiology, University Hospital Dusseldorf, University of Dusseldorf, 45147, Dusseldorf, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Heusch
authors.affiliation: Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45147, Essen, Germany.
authors.forename: Juliane
authors.initials: J
authors.lastname: Goebel
authors.affiliation: Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45147, Essen, Germany.
authors.forename: Kai
authors.initials: K
authors.lastname: Nassenstein
authors.affiliation: Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45147, Essen, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Schlosser
mesh_terms: D000328:Adult; D003287:Contrast Media; D005240:Feasibility Studies; D005260:Female; D019788:Fluorodeoxyglucose F18; D005682:Gadolinium; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D064847:Multimodal Imaging; D009205:Myocarditis / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D011446:Prospective Studies; D019275:Radiopharmaceuticals
chemical_list: D003287:Contrast Media; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005682:Gadolinium
keywords: Fluorodeoxyglucose (FDG); PET imaging; PET/MR imaging; cardiovascular magnetic; myocarditis; resonance imaging