title: A Critical Review of Properties and Analytical Methods for the Determination of Oxytetracyline in Biological and Pharmaceutical Matrices.
abstract: Antibiotics have an unquestionable importance in the treatment of many infections. Oxytetracycline is an antibiotic belonging to the class of tetracyclines, available for use in human and veterinary medicine. Development of analytical methods that prove the quality and efficacy of these drugs is fundamentally important to the pharmaceutical industry. In this context, the research presents an overview of the analytical profile of oxytetracycline, describing its chemical and pharmacological properties, and analytical methods for quantification of this drug in biological samples and pharmaceutical products. Oxytetracycline can be analyzed in these matrices by many types of methodologies. However, high-performance liquid chromatography is the most widely used, being recommended by official compendia. This kind of study can be useful to support the development of new efficient and sustainable analytical methods that may be utilized in the quality control routine of oxytetracycline in pharmaceutical products and pharmacokinetic monitoring in biological samples.
authors.affiliation: a Department of Pharmaceuticals , School of Pharmaceutical Sciences, São Paulo State University , Araraquara, São Paulo , Brazil.
authors.forename: Rúbia Adrieli
authors.initials: RA
authors.lastname: Sversut
authors.affiliation: b Center of Biological and Health Sciences, Pharmacy Course, Federal University of Mato Grosso do Sul , Campo Grande-MS , Brazil.
authors.forename: Adriane Andrade
authors.initials: AA
authors.lastname: da Silva
authors.affiliation: b Center of Biological and Health Sciences, Pharmacy Course, Federal University of Mato Grosso do Sul , Campo Grande-MS , Brazil.
authors.forename: Teófilo Fernando Mazon
authors.initials: TF
authors.lastname: Cardoso
authors.affiliation: b Center of Biological and Health Sciences, Pharmacy Course, Federal University of Mato Grosso do Sul , Campo Grande-MS , Brazil.
authors.forename: Nájla Mohamad
authors.initials: NM
authors.lastname: Kassab
authors.affiliation: c Institute of Physics, Federal University of Mato Grosso do Sul , Campo Grande-MS , Brazil.
authors.forename: Marcos Serrou
authors.initials: MS
authors.lastname: do Amaral
authors.affiliation: a Department of Pharmaceuticals , School of Pharmaceutical Sciences, São Paulo State University , Araraquara, São Paulo , Brazil.
authors.forename: Hérida Regina Nunes
authors.initials: HR
authors.lastname: Salgado
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D010118:Oxytetracycline / Q000032:analysis*; D004364:Pharmaceutical Preparations / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D004364:Pharmaceutical Preparations; D010118:Oxytetracycline
keywords: Analytical methods; liquid chromatography; oxytetracycline; pharmacological properties; quality control