title: The role of pulmonary resection in tumors metastatic from esophageal carcinoma.
abstract: OBJECTIVE
  The purposes of this study were to determine the role of surgical treatment and to identify factors affecting survival of patients undergoing resection of pulmonary metastatic tumors from esophageal carcinoma.
  
  
  METHODS
  We reviewed 33 patients who had undergone resection of pulmonary metastatic tumors from esophageal carcinoma after definitive treatment.
  
  
  RESULTS
  The operative morbidity rate was only 5%, no patients died within 30 days after resection, and complete resection was achieved in 30 patients. The overall 1-, 3- and 5-year survival rates after pulmonary metastasectomy were 79.4, 47.8 and 43.0%, respectively, and the median survival time was 17.9 months. The factors found on univariate analysis to affect survival significantly were disease-free interval <16 months and nodal involvement of the primary tumor. The most frequent pattern of initial recurrence after pulmonary resection was distant metastasis (70%).
  
  
  CONCLUSIONS
  We demonstrated the safety and effectiveness of surgical resection for selected patients with pulmonary metastatic tumors from esophageal carcinoma. However, with a high recurrence rate in patients with negative prognostic factors, adjuvant systemic chemotherapy after pulmonary resection should be considered.
authors.affiliation: Division of Esophageal Surgery, National Cancer Center Hospital East , Kashiwa.|Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya.
authors.forename: Jun
authors.initials: J
authors.lastname: Kanamori
authors.affiliation: Division of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
authors.forename: Keiju
authors.initials: K
authors.lastname: Aokage
authors.affiliation: Division of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Hishida
authors.affiliation: Division of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
authors.forename: Junji
authors.initials: J
authors.lastname: Yoshida
authors.affiliation: Division of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tsuboi
authors.affiliation: Division of Esophageal Surgery, National Cancer Center Hospital East , Kashiwa.
authors.forename: Takeo
authors.initials: T
authors.lastname: Fujita
authors.affiliation: Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya.
authors.forename: Masato
authors.initials: M
authors.lastname: Nagino
authors.affiliation: Division of Esophageal Surgery, National Cancer Center Hospital East , Kashiwa hdaikou@east.ncc.go.jp.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Daiko
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000473:pathology*; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D004938:Esophageal Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011013:Pneumonectomy; D011379:Prognosis; D012189:Retrospective Studies
keywords: esophageal carcinoma; metastasectomy; prognostic factors