title: Comparative Effect of Insulin Sensitizers and Statin on Metabolic Profile and Ultrasonographical Score in Non Alcoholic Fatty Liver Disease.
abstract: BACKGROUND
  Non Alcoholic Fatty Liver Disease (NAFLD) is a metabolic disorder involving fat accumulation in the liver. The initial management for patients with NAFLD includes lifestyle modification and weight loss in overweight or obese patients.
  
  
  OBJECTIVE
  The present study was conducted to compare the efficacy of insulin sensitizers and statin in the patients of NAFLD.
  
  
  METHODS
  The study included 98 patients diagnosed with NAFLD on USG (Ultrasonography) abdomen, divided into three Groups randomly and administered Metformin (Group I), Rosuvastatin (Group II) or Pioglitazone (Group III) along with dietary intervention and lifestyle modification. Their Body Mass Index (BMI), liver function tests, fasting lipid profile, USG scores for fatty liver were done and followed up at 4 weeks, 12 weeks and 24 week for change in above parameters.
  
  
  RESULTS
  Out of the three Groups, Group II showed a maximum improvements in usg scores for NAFLD (p<0.001) and fasting lipid profile. Group II also showed maximum derangement of liver enzymes at 24 weeks though none of the subjects had more than three times elevation of liver enzymes.
  
  
  CONCLUSIONS
  Rosuvastatin may be an effective therapy as add on treatment to dietary and lifestyle intervention in patients of NAFLD. As an add-on treatment Rosuvastatin was superior to Pioglitazone or Metformin and acute decompensation is unlikely with this drug. Metformin was not effective as add on therapy for NAFLD, rather rapid weight loss in short period of time resulted in worsening of hepatic steatosis.
authors.affiliation: Junior Resident, Department of Medicine, King George's Medical University , Lucknow, Uttar Pradesh, India .
authors.forename: Himanshu
authors.initials: H
authors.lastname: Rana
authors.affiliation: Senior Resident, Department of Pharmacology, King George's Medical University , Lucknow, Uttar Pradesh, India .
authors.forename: Suraj Singh
authors.initials: SS
authors.lastname: Yadav
authors.affiliation: Associate Professor, Department of Medicine, King George's Medical University , Lucknow, Uttar Pradesh, India .
authors.forename: Himanshu D
authors.initials: HD
authors.lastname: Reddy
authors.affiliation: Junior Resident, Department of Medicine, King George's Medical University , Lucknow, Uttar Pradesh, India .
authors.forename: Shubham
authors.initials: S
authors.lastname: Singhal
authors.affiliation: Junior Resident, Department of Medicine, King George's Medical University , Lucknow, Uttar Pradesh, India .
authors.forename: Dinesh Kumar
authors.initials: DK
authors.lastname: Singh
authors.affiliation: Professor, Department of Medicine, King George's Medical University , Lucknow, Uttar Pradesh, India .
authors.forename: Kauser
authors.initials: K
authors.lastname: Usman
keywords: Metformin; NAFLD; Pharmacotherapy; Pioglitazone; Rosuvastatin