title: Bisphenol A induces hypothalamic down-regulation of the the cannabinoid receptor 1 and anorexigenic effects in male mice.
abstract: Bisphenol A is an environment-polluting industrial chemical able to interfere with the endocrine system. An obesogenic effect in perinatally exposed rodents has been described as estrogenic activity. We exposed male mice to Bisphenol A during fetal-perinatal period (from 10 days post coitum to 31 days post partum) and investigated the effects of this early-life exposure at 78 days of age. Body weight, food intake, fat mass, and hypothalamic signals related to anorexigenic control of food intake were analyzed. Results show that Bisphenol A exposure reduced body weight and food intake. In addition, the exposure decreased epididymal fat mass and adiposity, acting negatively on adipocyte volume. At hypothalamic level, Bisphenol A exposure reduced the expression of the cannabinoid receptor 1 and induced gene expression of cocaine and amphetamine-regulated transcript-1. This observation suggests that Bisphenol A induces activation of anorexigenic signals via down-regulation of the hypothalamic cannabinoid receptor 1 with negative impact on food intake.
authors.affiliation: Department of Experimental Medicine, Sez. Bottazzi, II University of Naples, 80138, Napoli, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Suglia
authors.affiliation: Department of Experimental Medicine, Sez. Bottazzi, II University of Naples, 80138, Napoli, Italy.
authors.forename: Rosanna
authors.initials: R
authors.lastname: Chianese
authors.affiliation: Department of Experimental Medicine, Sez. Bottazzi, II University of Naples, 80138, Napoli, Italy.
authors.forename: Marina
authors.initials: M
authors.lastname: Migliaccio
authors.affiliation: Department of Science and Technology University of Sannio, Via Port'Arsa 11, 82100, Benevento, Italy; IRGS, Biogem, Via Camporeale, 83031, Ariano Irpino, Avellino, Italy.
authors.forename: Concetta
authors.initials: C
authors.lastname: Ambrosino
authors.affiliation: Department of Experimental Medicine, Sez. Bottazzi, II University of Naples, 80138, Napoli, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Fasano
authors.affiliation: Department of Experimental Medicine, Sez. Bottazzi, II University of Naples, 80138, Napoli, Italy. Electronic address: riccardo.pierantoni@unina2.it.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Pierantoni
authors.affiliation: Department of Experimental Medicine, Sez. Bottazzi, II University of Naples, 80138, Napoli, Italy.
authors.forename: Gilda
authors.initials: G
authors.lastname: Cobellis
authors.affiliation: Department of Experimental Medicine, Sez. Bottazzi, II University of Naples, 80138, Napoli, Italy.
authors.forename: Teresa
authors.initials: T
authors.lastname: Chioccarelli
mesh_terms: D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism; D050154:Adiposity / Q000187:drug effects; D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002186:Cannabinoids / Q000378:metabolism*; D015536:Down-Regulation / Q000187:drug effects*; D004435:Eating / Q000187:drug effects; D015870:Gene Expression / Q000187:drug effects; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D010636:Phenols / Q000494:pharmacology*; D043884:Receptor, Cannabinoid, CB1 / Q000378:metabolism*; D000098826:Bisphenol A Compounds
chemical_list: D001067:Appetite Depressants; D001559:Benzhydryl Compounds; D002186:Cannabinoids; D010636:Phenols; D043884:Receptor, Cannabinoid, CB1; C543264:Cnr1 protein, rat; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: BPA; CB1 receptor; Estrogens; Food intake; Hypothalamus; POMC/CART anorexigenic signals