title: New steroids from Anemarrhena asphodeloides rhizome and their α-glucosidase inhibitory activity.
abstract: Two new steroids were isolated from acid hydrolysis residue of the rhizomes of Anemarrhena asphodeloides. Their structures were identified on the basis of several spectroscopic analysis approaches including 1D, 2D-NMR techniques, and MS data, and by the comparison of spectral data of the known compounds. The biological activities of these two isolated compounds were explored on α-glucosidase. Compound 1 displayed 4.7 folds inhibitory activity against α-glucosidase compared with the positive control acarbose.
authors.affiliation: a Faculty of Chemistry , Thai Nguyen University of Education , Thai Nguyen City 250000 , Viet Nam.|b Shanghai Key Laboratory of New Drug Design, School of Pharmacy , East China University of Science and Technology , Shanghai 200237 , China.
authors.forename: Pham Van
authors.initials: PV
authors.lastname: Khang
authors.affiliation: a Faculty of Chemistry , Thai Nguyen University of Education , Thai Nguyen City 250000 , Viet Nam.
authors.forename: Dao Mai
authors.initials: DM
authors.lastname: Phuong
authors.affiliation: b Shanghai Key Laboratory of New Drug Design, School of Pharmacy , East China University of Science and Technology , Shanghai 200237 , China.
authors.forename: Lei
authors.initials: L
authors.lastname: Ma
mesh_terms: D031403:Anemarrhena / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013150:Spirostans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000520:alpha-Glucosidases / Q000187:drug effects*
chemical_list: C000617252:21-formyl sarsasapogenin; C000617230:21-hydroxysarsasapogenin; D004365:Drugs, Chinese Herbal; D065089:Glycoside Hydrolase Inhibitors; D012503:Saponins; D013150:Spirostans; D013256:Steroids; D000520:alpha-Glucosidases
keywords: Anemarrhena asphodeloides; inhibitory activity; steroid; α-glucosidase