title: Stress-driven lymphatic dissemination: An unanticipated consequence of communication between the sympathetic nervous system and lymphatic vasculature.
abstract: Chronic stress drives cancer progression, but the routes of metastasis are unclear. We recently demonstrated that chronic stress activates a neural-inflammatory signaling axis to remodel lymphatic vasculature and increase lymph flow. This unanticipated crosstalk between stress and the lymphatic system provides pathways of tumor cell dissemination and accelerates metastasis.
authors.affiliation: Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, Victoria, Australia.
authors.forename: Caroline P
authors.initials: CP
authors.lastname: Le
authors.affiliation: Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Department of Cancer and Pain Medicine, Peter MacCallum Cancer, East Melbourne, Victoria, Australia; Cousins Center for PNI, UCLA Semel Institute, Jonsson Comprehensive Cancer Center, and UCLA AIDS Institute, University of California Los Angeles, Los Angeles, CA, USA.
authors.forename: Erica K
authors.initials: EK
authors.lastname: Sloan
keywords: Adrenergic; lymphatic; metastasis; sympathetic nervous system; β-blocker