title: IL-17A attracts inflammatory cells in murine lung infection with P. aeruginosa.
abstract: IL-17A-dependent immunity is of importance in the protection against extracellular bacterial pathogens. However, IL-17A is also suggested to mediate the pathogenesis of lung diseases, such as acute respiratory distress syndrome. Here, we studied the role of IL-17A in a mouse model of acute pneumonia. IL-17A mediated the expression of keratinocyte-derived chemokine (KC) and the recruitment of inflammatory cells in mice infected with a sub-lethal dose of Pseudomonas aeruginosa. IL-17A deficiency protected mice from lethal P. aeruginosa lung infection. A sub-lethal infection with Streptococcus pneumoniae resulted in increased bacterial burden associated with increased pulmonary inflammation. Thus, the type of infectious bacteria seemed to influence the way in which IL-17A functions during pulmonary infection. Reducing pulmonary inflammation by targeting IL-17A may be a therapeutic option in acute P. aeruginosa pneumonia.
authors.affiliation: 1 Institute for Anatomy and Cell Biology, Germany.
authors.forename: Bodo
authors.initials: B
authors.lastname: Wonnenberg
authors.affiliation: 2 Department of Internal Medicine V - Pulmonology, Allergology and Respiratory Critical Care Medicine, Germany.
authors.forename: Christopher
authors.initials: C
authors.lastname: Jungnickel
authors.affiliation: 2 Department of Internal Medicine V - Pulmonology, Allergology and Respiratory Critical Care Medicine, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Honecker
authors.affiliation: 2 Department of Internal Medicine V - Pulmonology, Allergology and Respiratory Critical Care Medicine, Germany.
authors.forename: Lisa
authors.initials: L
authors.lastname: Wolf
authors.affiliation: 2 Department of Internal Medicine V - Pulmonology, Allergology and Respiratory Critical Care Medicine, Germany.
authors.forename: Meike
authors.initials: M
authors.lastname: Voss
authors.affiliation: 3 Institute of Medical Microbiology and Hygiene Saarland University, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Bischoff
authors.affiliation: 1 Institute for Anatomy and Cell Biology, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Tschernig
authors.affiliation: 2 Department of Internal Medicine V - Pulmonology, Allergology and Respiratory Critical Care Medicine, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Herr
authors.affiliation: 2 Department of Internal Medicine V - Pulmonology, Allergology and Respiratory Critical Care Medicine, Germany.
authors.forename: Robert
authors.initials: R
authors.lastname: Bals
authors.affiliation: 2 Department of Internal Medicine V - Pulmonology, Allergology and Respiratory Critical Care Medicine, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Beisswenger
mesh_terms: D000818:Animals; D002465:Cell Movement; D002478:Cells, Cultured; D006801:Humans; D007109:Immunity / Q000235:genetics; D020381:Interleukin-17 / Q000235:genetics / Q000378:metabolism*; D015603:Keratinocytes / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D058990:Molecular Targeted Therapy; D011008:Pneumococcal Infections / Q000276:immunology* / Q000628:therapy; D011014:Pneumonia / Q000276:immunology*; D011552:Pseudomonas Infections / Q000276:immunology* / Q000628:therapy; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D012128:Respiratory Distress Syndrome / Q000276:immunology* / Q000628:therapy; D013045:Species Specificity; D013296:Streptococcus pneumoniae / Q000276:immunology*
chemical_list: D020381:Interleukin-17
keywords: IL-17A; P. aeruginosa; inflammation; pathology; pneumonia