title: ZikaVR: An Integrated Zika Virus Resource for Genomics, Proteomics, Phylogenetic and Therapeutic Analysis.
abstract: Current Zika virus (ZIKV) outbreaks that spread in several areas of Africa, Southeast Asia, and in pacific islands is declared as a global health emergency by World Health Organization (WHO). It causes Zika fever and illness ranging from severe autoimmune to neurological complications in humans. To facilitate research on this virus, we have developed an integrative multi-omics platform; ZikaVR (http://bioinfo.imtech.res.in/manojk/zikavr/), dedicated to the ZIKV genomic, proteomic and therapeutic knowledge. It comprises of whole genome sequences, their respective functional information regarding proteins, genes, and structural content. Additionally, it also delivers sophisticated analysis such as whole-genome alignments, conservation and variation, CpG islands, codon context, usage bias and phylogenetic inferences at whole genome and proteome level with user-friendly visual environment. Further, glycosylation sites and molecular diagnostic primers were also analyzed. Most importantly, we also proposed potential therapeutically imperative constituents namely vaccine epitopes, siRNAs, miRNAs, sgRNAs and repurposing drug candidates.
authors.affiliation: Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh, 160036, India.
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Gupta
authors.affiliation: Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh, 160036, India.
authors.forename: Karambir
authors.initials: K
authors.lastname: Kaur
authors.affiliation: Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh, 160036, India.
authors.forename: Akanksha
authors.initials: A
authors.lastname: Rajput
authors.affiliation: Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh, 160036, India.
authors.forename: Sandeep Kumar
authors.initials: SK
authors.lastname: Dhanda
authors.affiliation: Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh, 160036, India.
authors.forename: Manika
authors.initials: M
authors.lastname: Sehgal
authors.affiliation: Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh, 160036, India.
authors.forename: Md Shoaib
authors.initials: MS
authors.lastname: Khan
authors.affiliation: Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh, 160036, India.
authors.forename: Isha
authors.initials: I
authors.lastname: Monga
authors.affiliation: Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh, 160036, India.
authors.forename: Showkat Ahmad
authors.initials: SA
authors.lastname: Dar
authors.affiliation: Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh, 160036, India.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Singh
authors.affiliation: Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh, 160036, India.
authors.forename: Gandharva
authors.initials: G
authors.lastname: Nagpal
authors.affiliation: Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh, 160036, India.
authors.forename: Salman Sadullah
authors.initials: SS
authors.lastname: Usmani
authors.affiliation: Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh, 160036, India.
authors.forename: Anamika
authors.initials: A
authors.lastname: Thakur
authors.affiliation: Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh, 160036, India.
authors.forename: Gazaldeep
authors.initials: G
authors.lastname: Kaur
authors.affiliation: Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh, 160036, India.
authors.forename: Shivangi
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh, 160036, India.
authors.forename: Aman
authors.initials: A
authors.lastname: Bhardwaj
authors.affiliation: Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh, 160036, India.
authors.forename: Abid
authors.initials: A
authors.lastname: Qureshi
authors.affiliation: Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh, 160036, India.
authors.forename: Gajendra Pal Singh
authors.initials: GP
authors.lastname: Raghava
authors.affiliation: Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh, 160036, India.
authors.forename: Manoj
authors.initials: M
authors.lastname: Kumar
mesh_terms: D000818:Animals; D003062:Codon / Q000235:genetics; D016679:Genome, Viral; D006031:Glycosylation; D006801:Humans; D025202:Molecular Diagnostic Techniques; D058977:Molecular Sequence Annotation; D010802:Phylogeny; D040901:Proteomics; D012367:RNA, Viral / Q000378:metabolism; D012984:Software; D014764:Viral Proteins / Q000378:metabolism; D000071244:Zika Virus / Q000145:classification* / Q000235:genetics*; D000071243:Zika Virus Infection / Q000628:therapy* / Q000821:virology
chemical_list: D003062:Codon; D012367:RNA, Viral; D014764:Viral Proteins