title: Genetics of Takotsubo Syndrome.
abstract: Takotsubo syndrome (TTS) is an enigmatic disease with a multifactorial and still unresolved pathogenesis. A genetic predisposition has been suggested based on the few familial TTS cases. Conflicting results have been published regarding the role of functional polymorphisms in relevant candidate genes, such as α1-, β1-, and β2-adrenergic receptors; G protein-coupled receptor kinase 5; and estrogen receptors. Further research is required to help clarify the role of genetic susceptibility in TTS.
authors.affiliation: Cardiologia SUN, Monaldi Hospital, AORN dei Colli, Second University of Naples, Via L Bianchi, Naples 80100, Italy. Electronic address: limongelligiuseppe@libero.it.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Limongelli
authors.affiliation: Cardiologia SUN, Monaldi Hospital, AORN dei Colli, Second University of Naples, Via L Bianchi, Naples 80100, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Masarone
authors.affiliation: Genomic and Cellular Lab, Monaldi Hospital, AORN dei Colli, Second University of Naples, Via L Bianchi, Naples 80100, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Maddaloni
authors.affiliation: Cardiologia SUN, Monaldi Hospital, AORN dei Colli, Second University of Naples, Via L Bianchi, Naples 80100, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Rubino
authors.affiliation: Cardiologia SUN, Monaldi Hospital, AORN dei Colli, Second University of Naples, Via L Bianchi, Naples 80100, Italy.
authors.forename: Fiorella
authors.initials: F
authors.lastname: Fratta
authors.affiliation: Cardiologia SUN, Monaldi Hospital, AORN dei Colli, Second University of Naples, Via L Bianchi, Naples 80100, Italy.
authors.forename: Annapaola
authors.initials: A
authors.lastname: Cirillo
authors.affiliation: Cardiologia SUN, Monaldi Hospital, AORN dei Colli, Second University of Naples, Via L Bianchi, Naples 80100, Italy.
authors.forename: Spinelli Barrile
authors.initials: SB
authors.lastname: Ludovica
authors.affiliation: Cardiologia SUN, Monaldi Hospital, AORN dei Colli, Second University of Naples, Via L Bianchi, Naples 80100, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Pacileo
authors.affiliation: Cardiologia SUN, Monaldi Hospital, AORN dei Colli, Second University of Naples, Via L Bianchi, Naples 80100, Italy.
authors.forename: Adelaide
authors.initials: A
authors.lastname: Fusco
authors.affiliation: Cardiologia SUN, Monaldi Hospital, AORN dei Colli, Second University of Naples, Via L Bianchi, Naples 80100, Italy.
authors.forename: Guido Ronald
authors.initials: GR
authors.lastname: Coppola
authors.affiliation: Cardiologia SUN, Monaldi Hospital, AORN dei Colli, Second University of Naples, Via L Bianchi, Naples 80100, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Pisacane
authors.affiliation: Heart Department, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", Salerno, Italy; Cardiology Division, Heart Department, "Cava de' Tirreni and Amalfi Coast" Hospital, University of Salerno, via De Marinis, Cava de" Tirreni (SA) 84013, Italy.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Bossone
authors.affiliation: Cardiologia SUN, Monaldi Hospital, AORN dei Colli, Second University of Naples, Via L Bianchi, Naples 80100, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Calabrò
authors.affiliation: Cardiologia SUN, Monaldi Hospital, AORN dei Colli, Second University of Naples, Via L Bianchi, Naples 80100, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Calabrò
authors.affiliation: Cardiologia SUN, Monaldi Hospital, AORN dei Colli, Second University of Naples, Via L Bianchi, Naples 80100, Italy.
authors.forename: Maria Giovanna
authors.initials: MG
authors.lastname: Russo
authors.affiliation: Cardiologia SUN, Monaldi Hospital, AORN dei Colli, Second University of Naples, Via L Bianchi, Naples 80100, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Pacileo
mesh_terms: D054774:G-Protein-Coupled Receptor Kinase 5 / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D018340:Receptors, Adrenergic, alpha-1 / Q000235:genetics; D018342:Receptors, Adrenergic, beta-1 / Q000235:genetics; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics; D054549:Takotsubo Cardiomyopathy / Q000235:genetics* / Q000473:pathology
chemical_list: C547713:ADRA1A protein, human; C547787:ADRB1 protein, human; C553443:ADRB2 protein, human; D018340:Receptors, Adrenergic, alpha-1; D018342:Receptors, Adrenergic, beta-1; D018343:Receptors, Adrenergic, beta-2; D054774:G-Protein-Coupled Receptor Kinase 5; C517898:GRK5 protein, human
keywords: Adrenoceptor polymorphisms; Catecholamine-induced myocardial toxicity; Takotsubo syndrome