title: Effect of the antimicrobial photodynamic therapy on microorganism reduction in deep caries lesions: a systematic review and meta-analysis.
abstract: This study aimed to perform a systematic review to assess the effectiveness of antimicrobial photodynamic therapy (aPDT) in the reduction of microorganisms in deep carious lesions. An electronic search was conducted in Pubmed, Web of Science, Scopus, Lilacs, and Cochrane Library, followed by a manual search. The MeSH terms, MeSH synonyms, related terms, and free terms were used in the search. As eligibility criteria, only clinical studies were included. Initially, 227 articles were identified in the electronic search, and 152 studies remained after analysis and exclusion of the duplicated studies; 6 remained after application of the eligibility criteria; and 3 additional studies were found in the manual search. After access to the full articles, three were excluded, leaving six for evaluation by the criteria of the Cochrane Collaboration’s tool for assessing risk of bias. Of these, five had some risk of punctuated bias. All results from the selected studies showed a significant reduction of microorganisms in deep carious lesions for both primary and permanent teeth. The meta-analysis demonstrated a significant reduction in microorganism counts in all analyses (p<0.00001). Based on these findings, there is scientific evidence emphasizing the effectiveness of aPDT in reducing microorganisms in deep carious lesions.
authors.affiliation: Fluminense Federal University, Department of Specific Formation, School of Dentistry, Rua Doutor Silvio Henrique Braune, 22, Centro-Nova Friburgo, Nova Friburgo, Rio de Janeiro, Brazil.
authors.forename: Pâmela Oliveira
authors.initials: PO
authors.lastname: Ornellas
authors.affiliation: Fluminense Federal University, Department of Specific Formation, School of Dentistry, Rua Doutor Silvio Henrique Braune, 22, Centro-Nova Friburgo, Nova Friburgo, Rio de Janeiro, Brazil.
authors.forename: Leonardo Dos Santos
authors.initials: LD
authors.lastname: Antunes
authors.affiliation: Fluminense Federal University, Department of Specific Formation, School of Dentistry, Rua Doutor Silvio Henrique Braune, 22, Centro-Nova Friburgo, Nova Friburgo, Rio de Janeiro, Brazil.
authors.forename: Karla Bianca Fernandes da Costa
authors.initials: KB
authors.lastname: Fontes
authors.affiliation: Fluminense Federal University, Department of Basic Science, School of Dentistry, Rua Doutor Silvio Henrique Braune, 22, Centro, Nova Friburgo, Rio de Janeiro, Brazil.
authors.forename: Helvécio Cardoso Corrêa
authors.initials: HC
authors.lastname: Póvoa
authors.affiliation: University of São Paulo, Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, Av. do Café, s/n - Ribeirão Preto, São Paulo, Brazil.
authors.forename: Erika Calvano
authors.initials: EC
authors.lastname: Küchler
authors.affiliation: Fluminense Federal University, Department of Basic Science, School of Dentistry, Rua Doutor Silvio Henrique Braune, 22, Centro, Nova Friburgo, Rio de Janeiro, Brazil.
authors.forename: Natalia Lopes Pontes
authors.initials: NL
authors.lastname: Iorio
authors.affiliation: Fluminense Federal University, Department of Specific Formation, School of Dentistry, Rua Doutor Silvio Henrique Braune, 22, Centro-Nova Friburgo, Nova Friburgo, Rio de Janeiro, Brazil.
authors.forename: Lívia Azeredo Alves
authors.initials: LA
authors.lastname: Antunes