title: CETP polymorphisms confer genetic contribution to centenarians of Hainan, south of China.
abstract: OBJECTIVE
  In this paper, we will discuss if the CETP polymorphism contributes to the centenarians in Hainan island.
  
  
  METHODS
  We tested the TaqIB and I405V polymorphisms of CETP gene among 276 centenarians and 301 matched healthy individuals by AS-PCR and analyzed the data with SPSS software package (Version 19.0).
  
  
  RESULTS
  Our data indicated that allele B1 and V have the significant differences between centenarians and healthy control groups with P < 0.001. Further analysis implied that genotypes B1B1 (P < 0.001, OR = 0.148, 95% CI = 0.095-0.230) and VV (P < 0.001 and OR = 0.353, 95% CI = 0.237-0.525) were significantly different between centenarians and matched controls. The combination of B and V, such as B1B1-II (P < 0.001, OR = 0.128, 95% CI = 0.049-0.329), B1B1-IV (P < 0.001, OR = 0.115, 95% CI = 0.056-0.237), B1B2-VV (P < 0.05, OR = 0.534, 95% CI = 0.310-0.920), and B2B2-VV (P < 0.001, OR = 0.198, 95% CI = 0.086-0.453) have significant differences between centenarians and matched healthy individuals from Hainan.
  
  
  CONCLUSIONS
  Our results implied that allele B1B1 and VV, as well as the combination B1B1-II, B1B1-IV, B1B2-VV and B2B2-VV may contribute to the longevity in centenarians of Hainan, south of China.
authors.affiliation: Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou, Hainan Province, China.
authors.forename: Yun-Xia
authors.initials: YX
authors.lastname: Zhang
authors.affiliation: Hainan Cadre Sanatorium/Geriatric Hospital of Hainan, Haikou, Hainan Province, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Su
authors.affiliation: Department of Reproduction and Genetics, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
authors.forename: Li
authors.initials: L
authors.lastname: Tang
authors.affiliation: Department of Reproduction and Genetics, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
authors.forename: Ze-Xing
authors.initials: ZX
authors.lastname: Yang
authors.affiliation: Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou, Hainan Province, China.
authors.forename: Dai-Feng
authors.initials: DF
authors.lastname: Zhou
authors.affiliation: Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou, Hainan Province, China.
authors.forename: Yi-Min
authors.initials: YM
authors.lastname: Qiu
authors.affiliation: Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou, Hainan Province, China. Electronic address: caiww591020@163.com.
authors.forename: Wang-Wei
authors.initials: WW
authors.lastname: Cai
keywords: Centenarians; Genetic contribution; Polymorphisms of CETP