title: Next-Generation Epidemiology: Using Real-Time Core Genome Multilocus Sequence Typing To Support Infection Control Policy.
abstract: Multidrug-resistant bacteria are responsible for substantial morbidity and mortality worldwide. Tracking the nosocomial spread of resistant bacteria is critical to infection control. Mellmann et al. (J. Clin. Microbiol. 54:2874-2881, 2016, http://dx.doi.org/10.1128/JCM.00790-16) have described prospective whole-genome sequencing with core genome multilocus sequencing typing (cgMLST) analysis for real-time surveillance and have addressed the practical aspects of implementing this type of operation in the hospital setting.
authors.affiliation: Department of Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.
authors.forename: John P
authors.initials: JP
authors.lastname: Dekker
authors.affiliation: Department of Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, Maryland, USA Karen.frank@nih.gov.
authors.forename: Karen M
authors.initials: KM
authors.lastname: Frank
mesh_terms: D003428:Cross Infection / Q000382:microbiology*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D016984:Enterococcus faecium / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D016680:Genome, Bacterial / Q000235:genetics*; D005858:Germany; D006761:Hospitals; D006801:Humans; D017053:Infection Control / Q000379:methods*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000235:genetics / Q000302:isolation & purification; D017720:Molecular Epidemiology / Q000379:methods*; D058885:Multilocus Sequence Typing / Q000379:methods*; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D065507:Vancomycin-Resistant Enterococci / Q000235:genetics / Q000302:isolation & purification