title: Identification of Circulating MiR-25 as a Potential Biomarker for Pancreatic Cancer Diagnosis.
abstract: BACKGROUND
  The aim of this study was to identify novel microRNAs for potential use in the diagnosis of pancreatic cancer (PaC).
  
  
  METHODS
  A total of 1063 serum samples from 303 patients with PaC were collected, and the expression level of miR-25 was measured using quantitative real-time PCR (qRT-PCR).
  
  
  RESULTS
  We found that miR-25 had significant diagnostic value for the differential diagnosis of PaC in normal controls with an AUC (the area under the ROC curve) of 0.915 (95% CI: 0.893-0.937) that was significantly higher compared with an AUC of 0.725 for serum tumor marker carcinoembryonic antigen (CEA) and an AUC of 0.844 for CA19-9.
  
  
  CONCLUSIONS
  These data suggest that serum miR-25 has strong potential as a novel biomarker for the early detection of PaC.
authors.affiliation: Department of Gastrointestinal Medical Oncology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center of Cancer; Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Deng
authors.forename: Yaozong
authors.initials: Y
authors.lastname: Yuan
authors.forename: Chunni
authors.initials: C
authors.lastname: Zhang
authors.forename: Chenyu
authors.initials: C
authors.lastname: Zhang
authors.forename: Weiyan
authors.initials: W
authors.lastname: Yao
authors.forename: Cheng
authors.initials: C
authors.lastname: Wang
authors.forename: Rui
authors.initials: R
authors.lastname: Liu
authors.forename: Yi
authors.initials: Y
authors.lastname: Ba
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D014408:Biomarkers, Tumor / Q000097:blood* / Q000235:genetics; D018395:CA-19-9 Antigen / Q000097:blood / Q000235:genetics; D002272:Carcinoembryonic Antigen / Q000097:blood / Q000235:genetics; D016022:Case-Control Studies; D003937:Diagnosis, Differential; D042241:Early Diagnosis; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D015870:Gene Expression; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics; D008875:Middle Aged; D009367:Neoplasm Staging; D010179:Pancreas / Q000378:metabolism / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D050500:Pancreatitis, Chronic / Q000097:blood / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D012372:ROC Curve
chemical_list: D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen; C543351:MIRN25 microRNA, human; D035683:MicroRNAs