title: Major depressive disorder is associated with subsequent adult-onset asthma: a population-based cohort study.
abstract: To examine the incidence of asthma in adult patients with major depressive disorder (MDD).
  
  
  
  From the National Health Insurance database of Taiwan, we identified 30 169 adult patients who were newly diagnosed with MDD between 2000 and 2010. Individuals without depression were randomly selected four times and frequency matched for sex, age and year of diagnosis. Both cohorts were followed-up for the occurrence of asthma up to the end of 2011. Adjusted hazard ratios (aHRs) of asthma were estimated using the Cox proportional hazards method.
  
  
  
  The overall incidence of asthma was 1.91-fold higher in the MDD cohort than in the non-depression cohort (7.55 v. 3.96 per 1000 person-years), with an aHR of 1.66 (95% confidence interval (CI) 1.55-1.78). In both cohorts, the incidence of asthma was higher in patients and controls who were female, aged, with comorbidities and users of aspirin or beta-adrenergic receptor blockers. No significant difference was observed in the occurrence of asthma between patients with MDD treated with selective serotonin reuptake inhibitors (SSRIs) and those treated with non-SSRIs (SSRIs to non-SSRIs aHR = 1.03, 95% CI 0.91-1.17).
  
  
  
  Adult patients with MDD are at a higher risk of asthma than those without depression are.
authors.affiliation: Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University,Taichung,Taiwan.
authors.forename: T-C
authors.initials: TC
authors.lastname: Shen
authors.affiliation: Management Office for Health Data, China Medical University Hospital,Taichung,Taiwan.
authors.forename: C-L
authors.initials: CL
authors.lastname: Lin
authors.affiliation: Department of Psychiatry,China Medical University Hospital,Taichung,Taiwan.
authors.forename: C H
authors.initials: CH
authors.lastname: Liao
authors.affiliation: Children's Hospital, China Medical University Hospital,Taichung,Taiwan.
authors.forename: C-C
authors.initials: CC
authors.lastname: Wei
authors.affiliation: Management Office for Health Data, China Medical University Hospital,Taichung,Taiwan.
authors.forename: F-C
authors.initials: FC
authors.lastname: Sung
authors.affiliation: Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University,Taichung,Taiwan.
authors.forename: C-H
authors.initials: CH
authors.lastname: Kao
mesh_terms: D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use; D001249:Asthma / Q000175:diagnosis / Q000453:epidemiology*; D016022:Case-Control Studies; D015331:Cohort Studies; D016208:Databases, Factual; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D016016:Proportional Hazards Models; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D012737:Sex Factors; D013624:Taiwan / Q000453:epidemiology
chemical_list: D018687:Antidepressive Agents, Second-Generation; D017367:Selective Serotonin Reuptake Inhibitors
keywords: Asthma; cohort study; major depressive disorder (MDD); selective serotonin reuptake inhibitors (SSRIs)