title: Clinicopathological, Cytogenetic, and Prognostic Analysis of 131 Myeloid Sarcoma Patients.
abstract: Myeloid sarcoma (MS) is an extramedullary tumor of immature myeloid cells. We analyzed 131 patients with MS, including: (1) de novo MS; (2) MS with concomitant acute myeloid leukemia (AML); (3) MS following myelodysplastic syndrome, myeloproliferative neoplasm, or chronic myelogenous leukemia; and (4) MS as a recurrence of AML. The most common development site was the lymph node. Testicular lesions were statistically more frequent in MS as a recurrence of AML than in other types of MS (P=0.0183). MS tended to lack myeloid markers (myeloperoxidase was present in 63.2%, CD68 in 51.3%, CD13 in 48.7%, and CD33 in 48.7% of patients) and express T-cell markers such as CD3 (20.7%) and CD5 (34.2%). All T-cell marker-positive MS cases were negative for the αβ and γδ T-cell receptors on immunohistochemistry. Underlying myelodysplastic syndrome or myeloproliferative neoplasm was a poor prognostic factor (vs. de novo MS: P=0.0383; vs. MS with concomitant AML: P=0.0143). However, there was no statistical difference in prognosis between de novo MS and MS with concomitant AML (P=0.288). There were no significant differences in prognosis between the prognoses of T-cell marker-positive and T-cell marker-negative MS cases. In addition, CXCR4 expression was a poor prognostic factor in MS (P=0.0229). This study involves the largest MS cohort to date and expands the clinical and pathologic knowledge of the disease.
authors.affiliation: *Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Niigata †Department of Pathology, School of Medicine, Kurume University, Kurume, Japan ‡Dana-Farber Cancer Institute, Medical Oncology, Boston, MA.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kawamoto
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Miyoshi
authors.forename: Noriaki
authors.initials: N
authors.lastname: Yoshida
authors.forename: Jun
authors.initials: J
authors.lastname: Takizawa
authors.forename: Hirohito
authors.initials: H
authors.lastname: Sone
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohshima
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D053208:Kaplan-Meier Estimate; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D023981:Sarcoma, Myeloid / Q000235:genetics* / Q000401:mortality* / Q000473:pathology*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor