title: Association of polymorphisms in Dickopff (DKK) gene towards modulating risk for lung cancer in north Indians.
abstract: OBJECTIVE
  To investigate the association between the genetic variants of DKK4 (rs2073664), DKK3 (rs2291599, rs3206824 and rs7391689) and DKK2 (rs447372, rs419558 and rs17037102) and lung cancer predisposition in north Indians.
  
  
  METHODS
  A total of 600 subjects were genotyped using PCR restriction fragment length polymorphism technique. Association analysis was carried out using logistic regression approach.
  
  
  RESULTS
  DKK3 rs7396187 showed a protective effect (p = 0.01). Subjects with heterozygous genotype of DKK2 rs17037102 and rs419558 showed an increased risk. The variant genotype of the genotypic combination, DKK3 rs3206824 and DKK2 rs419558 showed a twofold increased risk (p = 0.008). Lung cancer risk increased four-times in subjects with variant genotype of all the three DKK2 variants.
  
  
  CONCLUSIONS
  DKK2 is certainly playing a crucial role in modulating cancer susceptibility.
authors.affiliation: Department of Biotechnology, Thapar University, Patiala, Punjab-147002, India.
authors.forename: Charu
authors.initials: C
authors.lastname: Bahl
authors.affiliation: Department of Pulmonary Medicine, Post Graduate Institute of Education & Medical Research (PGIMER), Sector 14, Chandigarh, India.
authors.forename: Navneet
authors.initials: N
authors.lastname: Singh
authors.affiliation: Department of Pulmonary Medicine, Post Graduate Institute of Education & Medical Research (PGIMER), Sector 14, Chandigarh, India.
authors.forename: Digambar
authors.initials: D
authors.lastname: Behera
authors.affiliation: Department of Biotechnology, Thapar University, Patiala, Punjab-147002, India.
authors.forename: Siddharth
authors.initials: S
authors.lastname: Sharma
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007194:India / Q000453:epidemiology; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D015810:Linkage Disequilibrium; D008175:Lung Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D012307:Risk Factors; D047368:Tumor Burden
chemical_list: D036341:Intercellular Signaling Peptides and Proteins
keywords: DKK; Wnt pathway; lung cancer