title: Cancer metabolism at a glance.
abstract: A defining hallmark of cancer is uncontrolled cell proliferation. This is initiated once cells have accumulated alterations in signaling pathways that control metabolism and proliferation, wherein the metabolic alterations provide the energetic and anabolic demands of enhanced cell proliferation. How these metabolic requirements are satisfied depends, in part, on the tumor microenvironment, which determines the availability of nutrients and oxygen. In this Cell Science at a Glance paper and the accompanying poster, we summarize our current understanding of cancer metabolism, emphasizing pathways of nutrient utilization and metabolism that either appear or have been proven essential for cancer cells. We also review how this knowledge has contributed to the development of anticancer therapies that target cancer metabolism.
authors.affiliation: Cancer Metabolism Research Unit, Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
authors.forename: Alexei
authors.initials: A
authors.lastname: Vazquez
authors.affiliation: Cancer Metabolism Research Unit, Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1QH, UK.
authors.forename: Jurre J
authors.initials: JJ
authors.lastname: Kamphorst
authors.affiliation: Cancer Metabolism Research Unit, Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1QH, UK.
authors.forename: Elke K
authors.initials: EK
authors.lastname: Markert
authors.affiliation: Cancer Metabolism Research Unit, Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
authors.forename: Zachary T
authors.initials: ZT
authors.lastname: Schug
authors.affiliation: Cancer Metabolism Research Unit, Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
authors.forename: Saverio
authors.initials: S
authors.lastname: Tardito
authors.affiliation: Cancer Metabolism Research Unit, Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK e.gottlieb@beatson.gla.ac.uk.
authors.forename: Eyal
authors.identifier: 0000-0002-9770-0956
authors.initials: E
authors.lastname: Gottlieb
mesh_terms: D000818:Animals; D005227:Fatty Acids / Q000096:biosynthesis; D006801:Humans; D053858:Metabolic Networks and Pathways; D055442:Metabolome; D008745:Methylation; D009369:Neoplasms / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D005227:Fatty Acids; D017382:Reactive Oxygen Species
keywords: Cancer; Metabolism; Targeted therapy