title: Cefoperazone Induced Gastrointestinal Bleeding.
abstract: Cefoperazone is a beta-lactam antibiotic which is frequently used in treating a variety of gram positive and gram negative infections. The chemical structure of cefoperazone contains a side chain of N-methylthiotetrazole which can inhibit vitamin K metabolism resulting in hypoprothombinemia. We report a case of cefoperazone induced coagulopathy manifesting as gastrointestinal bleeding. A Naranjo assessment score of 5 was obtained, indicating a probable relationship between the patient's coagulation function disorder and her use of the suspect drug.
authors.affiliation: Junior Resident, Department of General Medicine, Kasturba Medical College, Kasturba Hospital , Manipal, Udupi, Karnataka, India .
authors.forename: Goutham Reddy
authors.initials: GR
authors.lastname: Katukuri
authors.affiliation: Junior Resident, Department of General Medicine, Kasturba Medical College, Kasturba Hospital , Manipal, Udupi, Karnataka, India .
authors.forename: Raja Naga Mahesh
authors.initials: RN
authors.lastname: Maddala
authors.affiliation: Assistant Professor, Department of General Medicine, Kasturba Medical College, Kasturba Hospital , Manipal, Udupi, Karnataka, India .
authors.forename: Kusugodlu
authors.initials: K
authors.lastname: Ramamoorthi
authors.affiliation: Professor and HOD, Department of General Medicine, Kasturba Medical College, Kasturba Hospital , Manipal, Udupi, Karnataka, India .
authors.forename: Manjunatha
authors.initials: M
authors.lastname: Hande
keywords: Cefoperazone; Coagulopathy; Vitamin K