title: Pinpointing a Factor in Myeloma Bone Disease.
abstract: A recent study implicates thymidine phosphorylase in myeloma-induced bone disease and suggests that inhibiting the enzyme may be a viable therapeutic option. Thymidine phosphorylase provokes osteolytic lesions by disrupting the balance between bone resorption and formation, shifting it toward a net loss of bone tissue.
mesh_terms: D000818:Animals; D016723:Bone Remodeling / Q000187:drug effects; D001862:Bone Resorption / Q000150:complications / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002118:Calcium / Q000378:metabolism; D050659:Core Binding Factor Alpha 1 Subunit / Q000235:genetics*; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics*; D000090205:DNA Methyltransferase 3A; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D050835:Interferon Regulatory Factors / Q000235:genetics*; D051379:Mice; D009101:Multiple Myeloma / Q000150:complications / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D010010:Osteoclasts / Q000378:metabolism / Q000473:pathology; D000076182:Sp7 Transcription Factor; D013939:Thymidine Phosphorylase / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics*; D000099185:Interferon Regulatory Factor-8
chemical_list: D002118:Calcium; D050659:Core Binding Factor Alpha 1 Subunit; D004248:DNA (Cytosine-5-)-Methyltransferases; D000090205:DNA Methyltransferase 3A; D050835:Interferon Regulatory Factors; D000076182:Sp7 Transcription Factor; D013939:Thymidine Phosphorylase; D014157:Transcription Factors; D000099185:Interferon Regulatory Factor-8; C000717967:DNMT3A protein, human; C493709:RUNX2 protein, human; C478163:SP7 protein, human