title: Cyclophosphamide and epirubicin-induced diabetes mellitus in breast cancer: A rare occurrence.
abstract: Breast cancer is the leading cause of death in women. Epirubicin and cyclophosphamide (EC) is one of the chemotherapeutic regimens used for the treatment of breast cancer. We describe a case treated with EC regimen and who presented to us with symptoms suggestive of diabetes mellitus postchemotherapy. Absence of family history of diabetes and normal blood sugar level, prechemotherapy points toward drug-induced hyperglycemia. These chemotherapeutic agents capable of altering immune response and might act synergistically to cause immunological damage to the islets of pancreas which might precipitate diabetes mellitus. Causality analysis on Naranjo's scale indicates a possible association with regimen.
authors.affiliation: Department of Pharmacology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
authors.forename: Pramod Kumar
authors.initials: PK
authors.lastname: Sharma
authors.affiliation: Department of Pharmacology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
authors.forename: Arup Kumar
authors.initials: AK
authors.lastname: Misra
authors.affiliation: Department of Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
authors.forename: Vikram
authors.initials: V
authors.lastname: Singh
authors.affiliation: Department of Pharmacology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
authors.forename: Ajay
authors.initials: A
authors.lastname: Gupta
authors.affiliation: Department of Pharmacology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
authors.forename: Shrishti
authors.initials: S
authors.lastname: Saroha
authors.affiliation: Department of Pharmacology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
authors.forename: Surjit
authors.initials: S
authors.lastname: Singh
keywords: Cyclophosphamide; diabetes mellitus; epirubicin; hyperglycemia