title: Total Synthesis of Cytospolide D and Its Biomimetic Conversion to Cytospolides M, O, and Q.
abstract: A total synthesis of cytospolide D, starting from l-glutamic acid, is described. The critical macrolactonization to the 10-membered lactone containing an (E)-configured double bond was successfully achieved by Shiina esterification. Conversion of cytospolide D to its bicyclic derivatives M, O, and Q was accomplished under mild conditions, lending support to the proposed biosynthetic hypothesis.
authors.affiliation: Department of Chemistry, Institute of Organic Chemistry, University of Hamburg , Martin-Luther-King-Platz 6, 20146 Hamburg, Germany.
authors.forename: Gunnar
authors.initials: G
authors.lastname: Ehrlich
authors.affiliation: Department of Chemistry, Institute of Organic Chemistry, University of Hamburg , Martin-Luther-King-Platz 6, 20146 Hamburg, Germany.
authors.forename: Christian B W
authors.initials: CB
authors.lastname: Stark