title: Functional alterations of fronto-limbic circuit and default mode network systems in first-episode, drug-naïve patients with major depressive disorder: A meta-analysis of resting-state fMRI data.
abstract: The neurobiological mechanisms of depression are increasingly being explored through resting-state brain imaging studies. However, resting-state fMRI findings have varied, perhaps because of differences between study populations, which included the disorder course and medication use. The aim of our study was to integrate studies of resting-state fMRI and explore the alterations of abnormal brain activity in first-episode, drug-naïve patients with major depressive disorder.
  
  
  
  Relevant imaging reports in English were searched, retrieved, selected and subjected to analysis by activation likelihood estimation, a coordinate-based meta-analysis technique (final sample, 31 studies). Coordinates extracted from the original reports were assigned to two categories based on effect directionality.
  
  
  
  Compared with healthy controls, the first-episode, medication-naïve major depressive disorder patients showed decreased brain activity in the dorsolateral prefrontal cortex, superior temporal gyrus, posterior precuneus, and posterior cingulate, as well as in visual areas within the occipital lobe, lingual gyrus, and fusiform gyrus, and increased activity in the putamen and anterior precuneus.
  
  
  
  Not every study that has reported relevant data met the inclusion criteria.
  
  
  
  Resting-state functional alterations were located mainly in the fronto-limbic system, including the dorsolateral prefrontal cortex and putamen, and in the default mode network, namely the precuneus and superior/middle temporal gyrus. Abnormal functional alterations of the fronto-limbic circuit and default mode network may be characteristic of first-episode, drug-naïve major depressive disorder patients.
authors.affiliation: Medical Psychological Institute, Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Zhong
authors.affiliation: Medical Psychological Institute, Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
authors.forename: Weidan
authors.initials: W
authors.lastname: Pu
authors.affiliation: Medical Psychological Institute, Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China. Electronic address: shuqiaoyao@163.com.
authors.forename: Shuqiao
authors.initials: S
authors.lastname: Yao
mesh_terms: D001921:Brain / Q000503:physiopathology; D003865:Major Depressive Disorder / Q000503:physiopathology; D005625:Frontal Lobe / Q000503:physiopathology*; D006179:Gyrus Cinguli / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D009434:Neural Pathways / Q000503:physiopathology*; D009778:Occipital Lobe / Q000503:physiopathology; D012146:Rest / Q000523:psychology*; D012559:Schizophrenia / Q000503:physiopathology*; D013702:Temporal Lobe / Q000503:physiopathology
keywords: Drug-naïve major depressive disorder; First-episode; Meta-analysis; Resting-state fMRI