title: The Influence of Age and Gender on the Pro/Antioxidant Status in Young Healthy People.
abstract: The aim of the present study was to examine the influence of age and gender on the pro/antioxidant balance in young healthy subject aged 20-40 years. The individuals were divided into women: aged 20-25 years (group A), aged 32-39 years (group B), and men aged 20-25 years (group C). In blood, the metals, markers of oxidative stress and antioxidants were estimated. The Cu level and Cu/Zn ratio in group B was higher than in group A. There were no differences in metals concentrations between groups A and C. The similar levels of malondialdehyde concentrations and gamma-glutamyl transpeptidase activities were observed in all groups. The decrease in glutathione reduced and glutathione peroxidase was in group B than in group A. The higher glutathione reduced, lower glutathione oxidized concentrations and glutathione-dependent enzymes (glutathione reductase and glutathione peroxidase) were observed in group C when compared to group A. The superoxide dismutase and catalase activities were higher in groups B and C than in group A.The age and gender have an influence on the pro/antioxidant status in healthy people aged 20-40 years. The main antioxidants responsible for the removal of free radicals in men aged 20-25 years and women aged 32-39 years are superoxide dismutase and catalase, while the glutathione peroxidase activity declines. The detoxification being mediated through glutathione is weakened in women aged 32-39 years.
authors.affiliation: Department of Biomedical and Environmental Analysis, Faculty of Pharmacy, Wroclaw Medical University, Wrocław, Poland kasiakowalska1987@gmail.com.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kowalska
authors.affiliation: Department of Biomedical and Environmental Analysis, Faculty of Pharmacy, Wroclaw Medical University, Wrocław, Poland halina.milnerowicz@umed.wroc.pl.
authors.forename: Halina
authors.initials: H
authors.lastname: Milnerowicz
mesh_terms: D000328:Adult; D000367:Age Factors; D000375:Aging / Q000097:blood*; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D003300:Copper / Q000097:blood; D005260:Female; D019803:Glutathione Disulfide / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D016877:Oxidants / Q000097:blood*; D012727:Sex Characteristics; D013482:Superoxide Dismutase / Q000378:metabolism; D055815:Young Adult; D015032:Zinc / Q000097:blood; D005723:gamma-Glutamyltransferase
chemical_list: D000975:Antioxidants; D016877:Oxidants; D008315:Malondialdehyde; D003300:Copper; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005723:gamma-Glutamyltransferase; D005982:Glutathione Transferase; D015032:Zinc; D019803:Glutathione Disulfide
keywords: age; antioxidants; gender; metals; oxidative stress markers