title: Interactions Between α-Synuclein and Tau Protein: Implications to Neurodegenerative Disorders.
abstract: Tau and α-Synuclein (α-Syn) are abundant brain proteins with distinct biological functions. Findings suggest that interactions between α-Syn and tau at the cellular level cause disruption of cytoskeletal organization, axonal transport defects, and aberrant synaptic organization. The ability of tau and α-Syn to affect each other directly or indirectly might contribute to the overlap in the clinical and pathological features of tauopathies and synucleinopathies. The interactions between α-Syn and tau, and the underlying molecular pathogenic mechanisms, including induction and spread of protein aggregates, still deserve further investigation.
authors.affiliation: Department of Neurology, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, 150001, China.
authors.forename: Xuling
authors.initials: X
authors.lastname: Li
authors.affiliation: Oxidation Biology Unit, Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, Parkville, Victoria, 3052, Australia. simon.james@florey.edu.au.
authors.forename: Simon
authors.initials: S
authors.lastname: James
authors.affiliation: Oxidation Biology Unit, Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, Parkville, Victoria, 3052, Australia. peng.lei@scu.edu.cn.|Department of Neurology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, 610041, China. peng.lei@scu.edu.cn.
authors.forename: Peng
authors.identifier: http://orcid.org/0000-0001-5652-1962
authors.initials: P
authors.lastname: Lei
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D006801:Humans; D010300:Parkinson Disease / Q000378:metabolism* / Q000473:pathology; D011485:Protein Binding; D011499:Protein Processing, Post-Translational; D013569:Synapses / Q000378:metabolism; D051844:alpha-Synuclein / Q000235:genetics / Q000378:metabolism*; D016875:tau Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D051844:alpha-Synuclein; D016875:tau Proteins
keywords: Alzheimer’s disease; Neurodegeneration; Parkinson’s disease; Tau; α-Synuclein