title: The role of MDM4 SNP34091 A>C polymorphism in cancer: a meta-analysis on 19,328 patients and 51,058 controls.
abstract: BACKGROUND
  Cancer is one of the leading causes of death in the world. Several observational studies have suggested a significant association of the MDM4 SNP34091 A>C polymorphism with cancers. However, the results of the published studies are inconsistent.
  
  
  METHODS
  PubMed, Embase/Ovid and the Chinese National Knowledge Infrastructure were searched for relevant studies with a time limit of April 20, 2016. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of the association between MDM4 polymorphism and cancer risk. Publication bias was estimated using Begg's funnel plots and Egger's regression test.
  
  
  RESULTS
  A total of 19,328 patients and 51,058 controls were included in the analysis. Overall, a significantly decreased risk of cancer was associated with MDM4 SNP34091 polymorphism for the allele model (C vs. A, OR = 0.715, 95% CI: 0.622-0.821, p = 0.000), dominant model (CC + AC vs. AA, OR = 0.684, 95% CI: 0.563-0.831, p = 0.000), recessive model (CC vs. AC + AA, OR = 1.139, 95% CI = 1.055-1.230, p = 0.001) and heterozygote model (AC vs. AA, OR = 0.687, 95% CI = 0.568-0.832). In the subgroup analysis by cancer type, no significant association was found in the breast cancer subgroup. In the subgroup analysis by geographical region, 2 genetic models, the allele and heterozygote models, showed a significant association in Chinese populations.
  
  
  CONCLUSIONS
  The results of our meta-analysis showed that the MDM4 SNP34091 A>C polymorphism may function as a protective factor against cancer risk.
authors.affiliation: Department of Urology, The Affiliated Taizhou People's Hospital of Nantong University, Taizhou, Jiangsu - China.
authors.forename: Xin
authors.initials: X
authors.lastname: Jin
authors.affiliation: Department of Urology, The Affiliated Taizhou People's Hospital of Nantong University, Taizhou, Jiangsu - China.
authors.forename: Wenchao
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Department of Urology, The Affiliated Taizhou People's Hospital of Nantong University, Taizhou, Jiangsu - China.
authors.forename: Minghua
authors.initials: M
authors.lastname: Zheng
authors.affiliation: Department of Urology, The Affiliated Taizhou People's Hospital of Nantong University, Taizhou, Jiangsu - China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhou
authors.affiliation: Department of Urology, The Affiliated Taizhou People's Hospital of Nantong University, Taizhou, Jiangsu - China.
authors.forename: Tianli
authors.initials: T
authors.lastname: Niu
mesh_terms: D016022:Case-Control Studies; D018797:Cell Cycle Proteins; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D012307:Risk Factors
chemical_list: D018797:Cell Cycle Proteins; C482775:MDM4 protein, human; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins