title: Phylogenetic analysis of a transfusion-transmitted hepatitis A outbreak.
abstract: A transfusion-associated hepatitis A outbreak was found in the first time in Hungary. The outbreak involved five cases. Parenteral transmission of hepatitis A is rare, but may occur during viraemia. Direct sequencing of nested PCR products was performed, and all the examined samples were identical in the VP1/2A region of the hepatitis A virus genome. HAV sequences found in recent years were compared and phylogenetic analysis showed that the strain which caused these cases is the same as that had spread in Hungary recently causing several hepatitis A outbreaks throughout the country.
authors.affiliation: Division of Virology, National Reference Laboratory for Hepatitis Viruses, National Center for Epidemiology, Albert Flórián út 2-6, Budapest, 1097, Hungary.
authors.forename: Andrea
authors.initials: A
authors.lastname: Hettmann
authors.affiliation: Government Office of the Capital City Budapest, Policy Administration Services of Public Health, Budapest, Hungary.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Juhász
authors.affiliation: Division of Virology, National Reference Laboratory for Hepatitis Viruses, National Center for Epidemiology, Albert Flórián út 2-6, Budapest, 1097, Hungary.
authors.forename: Ágnes
authors.initials: Á
authors.lastname: Dencs
authors.affiliation: Division of Virology, National Reference Laboratory for Hepatitis Viruses, National Center for Epidemiology, Albert Flórián út 2-6, Budapest, 1097, Hungary.
authors.forename: Bálint
authors.initials: B
authors.lastname: Tresó
authors.affiliation: Division of Virology, National Reference Laboratory for Hepatitis Viruses, National Center for Epidemiology, Albert Flórián út 2-6, Budapest, 1097, Hungary.
authors.forename: Erzsébet
authors.initials: E
authors.lastname: Rusvai
authors.affiliation: National Blood Transfusion Service, Budapest, Hungary.
authors.forename: Éva
authors.initials: É
authors.lastname: Barabás
authors.affiliation: Division of Virology, National Reference Laboratory for Hepatitis Viruses, National Center for Epidemiology, Albert Flórián út 2-6, Budapest, 1097, Hungary. takmar@gmail.com.
authors.forename: Mária
authors.identifier: http://orcid.org/0000-0002-2492-6890
authors.initials: M
authors.lastname: Takács
mesh_terms: D000328:Adult; D000368:Aged; D004196:Disease Outbreaks; D005260:Female; D006506:Hepatitis A / Q000175:diagnosis / Q000453:epidemiology / Q000635:transmission* / Q000821:virology*; D030041:Hepatitis A virus / Q000145:classification* / Q000235:genetics*; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D008111:Liver Function Tests; D008297:Male; D010802:Phylogeny; D065227:Transfusion Reaction; D015678:Viral Structural Proteins / Q000235:genetics
chemical_list: C096539:VP1 protein, hepatitis A virus; D015678:Viral Structural Proteins
keywords: Hepatitis A; Outbreak; Phylogenetic analysis; Transfusion-transmitted