title: Electrochemically Modulated Nitric Oxide Release From Flexible Silicone Rubber Patch: Antimicrobial Activity For Potential Wound Healing Applications.
abstract: Herein, we report a novel design and the antimicrobial efficacy of a flexible nitric oxide (NO) releasing patch for potential wound healing applications. The compact sized polydimethylsiloxane (PDMS) planar patch generates NO via electrochemical reduction of nitrite ions mediated by a copper(II)-ligand catalyst using a portable power system and an internal gold coated stainless steel mesh working electrode. Patches are fabricated via soft lithography and 3-D printing. The devices can continuously release NO over 4 days and exhibit potent bactericidal effects on bothEscherichia coliandStaphylococcus aureus. The device may provide an effective, safe, and less costly alternative for treating chronic wounds.
authors.affiliation: Department of Chemistry, Department of Environmental Health Sciences, University of Michigan , Ann Arbor, Michigan 48109-1055, United States.
authors.forename: Woong Hee
authors.initials: WH
authors.lastname: Lee
authors.affiliation: Department of Chemistry, Department of Environmental Health Sciences, University of Michigan , Ann Arbor, Michigan 48109-1055, United States.
authors.forename: Hang
authors.initials: H
authors.lastname: Ren
authors.affiliation: Department of Chemistry, Department of Environmental Health Sciences, University of Michigan , Ann Arbor, Michigan 48109-1055, United States.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Electrical and Computer Engineering, University of Utah , Salt Lake City, Utah 84112, United States.
authors.forename: Ondrej
authors.initials: O
authors.lastname: Novak
authors.affiliation: Department of Electrical and Computer Engineering, University of Utah , Salt Lake City, Utah 84112, United States.
authors.forename: Richard B
authors.initials: RB
authors.lastname: Brown
authors.affiliation: Department of Chemistry, Department of Environmental Health Sciences, University of Michigan , Ann Arbor, Michigan 48109-1055, United States.
authors.forename: Chuanwu
authors.initials: C
authors.lastname: Xi
authors.affiliation: Department of Chemistry, Department of Environmental Health Sciences, University of Michigan , Ann Arbor, Michigan 48109-1055, United States.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Meyerhoff
keywords: 3D printing; antimicrobial patch; electrochemical devices; nitric oxide release; portable planar NO generation