title: Evaluation of correlations between frequencies of complete denture relines and serum levels of 3 bone metabolic markers: A cross-sectional pilot study.
abstract: BACKGROUND
  Continuous bone resorption is the primary reason for complete denture relines. Because resorption rates vary, the frequency at which individuals require relines also varies. Currently, there are no predictors to identify individuals at risk of frequent relines or to guide clinicians in decisions related to relines.
  
  
  OBJECTIVE
  The purpose of this cross-sectional pilot study was to determine the utility of measuring bone metabolic markers (C-terminal telopeptide, osteocalcin, 25-OH hydroxy vitamin D) to predict the frequency of complete denture relines.
  
  
  METHODS
  One hundred adult participants with complete dentures (either maxillary, mandibular, or both) participated in 1 dental clinic visit involving a dental examination and brief interview to obtain relevant medical and dental history, information on medication/supplement use, and 1 laboratory blood draw for the measurement of bone metabolic markers. Data were analyzed by using the Pearson correlation, independent Student t test, or analysis of variance (α=.05).
  
  
  RESULTS
  Significant correlations were found between the frequency of relines and C-telopeptide and osteocalcin levels but not with vitamin D or age. No significant associations with reline frequency and other factors (sex, ethnicity, presence or absence of diabetes, use of calcium and vitamin D supplements) were observed.
  
  
  CONCLUSIONS
  Elevated levels of bone turnover markers in individuals with edentulism were associated with increased frequency of denture relines.
authors.affiliation: Former graduate student, Advanced Specialty Education Program in Prosthodontics, Loma Linda University School of Dentistry, Loma Linda, Calif. Electronic address: spuri@llu.edu.
authors.forename: Shweta
authors.initials: S
authors.lastname: Puri
authors.affiliation: Professor, Advanced Specialty Education Program in Prosthodontics, Loma Linda University School of Dentistry, Loma Linda, Calif.
authors.forename: Mathew T
authors.initials: MT
authors.lastname: Kattadiyil
authors.affiliation: Assistant Professor, Department of Medicine, Loma Linda University School of Medicine, Loma Linda, Calif.
authors.forename: Nishant
authors.initials: N
authors.lastname: Puri
authors.affiliation: Physician, Veterans Affairs Loma Linda Healthcare System, Loma Linda, Calif; and Associate Professor, Department of Medicine and Department of Basic Science, Loma Linda University School of Medicine, Loma Linda, Calif.
authors.forename: Susan L
authors.initials: SL
authors.lastname: Hall
mesh_terms: D000368:Aged; D016301:Alveolar Bone Loss / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016723:Bone Remodeling / Q000502:physiology; D024042:Collagen Type I / Q000097:blood*; D003430:Cross-Sectional Studies; D003822:Denture Liners; D003824:Denture, Complete; D005260:Female; D006801:Humans; D008297:Male; D015675:Osteocalcin / Q000097:blood*; D010455:Peptides / Q000097:blood*; D010865:Pilot Projects; D011475:Prosthesis Failure; D014807:Vitamin D / Q000097:blood*
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D014807:Vitamin D