title: A dosimetric and treatment efficiency evaluation of stereotactic body radiation therapy for peripheral lung cancer using flattening filter free beams.
abstract: To investigate potential dosimetric benefits and treatment efficiency of dynamic conformal arc therapy (DCA), intensity modulated radiation therapy (IMRT), and double partial arcs Rapidarc (RA) techniques in the treatment of early-stage peripheral lung cancer using stereotactic body radiotherapy (SBRT) with flattening filter free (FFF) beams. Twenty early-stage peripheral lung cancer patients were selected. For each patient, DCA, IMRT and RA plans were created to meet Radiation Therapy Oncology Group (RTOG) 0915 objectives with 48 Gy covering 95% of the planning target volume (PTV) in 4 fractions. PTV coverage, organs at risk (OARs) doses, planning time, monitor units (MU) and treatment time were evaluated. RA was significantly better than DCA for PTV coverage. RA provided a lower V32Gy to chest wall and less V20Gy to lung over those of DCA and IMRT. For other OARs, there is no significant difference among all three techniques. DCA plans showed significantly less planning time, shorter treatment time and lower MU number than those of RA and IMRT. RA provides a superior dosimetric benefit to DCA and IMRT in the treatment of early-stage lung cancer using SBRT with FFF beams. Considering the MU number, planning time and treatment efficiency, DCA technique is an effective treatment strategy.
authors.affiliation: Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou 515031, China.
authors.forename: Ji-Yong
authors.initials: JY
authors.lastname: Zhang
authors.affiliation: Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou 515031, China.
authors.forename: Jia-Yang
authors.initials: JY
authors.lastname: Lu
authors.affiliation: Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou 515031, China.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Wu
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Shantou University Medical College, Shantou 515031, China.
authors.forename: Dan-Li
authors.initials: DL
authors.lastname: Hong
authors.affiliation: Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou 515031, China.
authors.forename: Chang-Chun
authors.initials: CC
authors.lastname: Ma
authors.affiliation: Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou 515031, China.
authors.forename: Xun
authors.initials: X
authors.lastname: Peng
authors.affiliation: Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou 515031, China.
authors.forename: Zhi-Xiong
authors.initials: ZX
authors.lastname: Lin
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000532:radiotherapy*; D008297:Male; D011874:Radiometry / Q000379:methods; D016634:Radiosurgery / Q000379:methods; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods; D016896:Treatment Outcome
keywords: dosimetric benefits; flattening filter free beams; lung cancer; stereotactic body radiation therapy