title: Interlinking Periodontitis and Type 2 Diabetes Mellitus by Assessment of Crevicular Visfatin Levels in Health and in Disease Before and After Initial Periodontal Therapy.
abstract: BACKGROUND
  Visfatin is a new adipocytokine associated with both chronic periodontitis and type 2 diabetes mellitus independently.
  
  
  OBJECTIVE
  We aimed to estimate and compare the changes in the levels of visfatin in the Gingival Crevicular Fluid (GCF) of healthy subjects and in subjects with periodontitis with or without controlled Type 2 Diabetes Mellitus (T2DM) after administration of non-surgical periodontal therapy.
  
  
  METHODS
  Forty two subjects were equally divided into Group 1 (healthy), Group 2 (systemically healthy with chronic periodontitis), Group 3 (subjects with chronic periodontitis having controlled T2DM). Defined clinical parameters were recorded at baseline and at one month follow-up period. Visfatin was assessed using enzyme linked immunosorbent assay. One way ANOVA and Tukey's multiple post hoc procedures were used. Pearson's correlation coefficient was used for correlation.
  
  
  RESULTS
  Significant increase in the visfatin levels was seen with the highest values observed in diabetes with periodontal disease. Visfatin responded to non-surgical periodontal therapy as observed by significant decrease in levels after one month but even at this period diabetics showed the highest levels.
  
  
  CONCLUSIONS
  Visfatin levels are highest in individuals with both periodontal disease and diabetes even after periodontal therapy. Individuals with T2DM may be at higher risk of developing periodontal disease.
authors.affiliation: Senior Lecturer, Department of Periodontics, Sri Sai College of Dental Surgery , Vikarabad, Telangana, India .
authors.forename: Vandita
authors.initials: V
authors.lastname: Mishra
authors.affiliation: Professor and Head, Department of Periodontics, S.D.M. College of Dental Sciences and Hospital , Dharwad, Karnataka, India .
authors.forename: Leena
authors.initials: L
authors.lastname: Shettar
authors.affiliation: Student, Department of Periodontics, SDM College of Dental Sciences and Hospital , Dharwad, Karnataka, India .
authors.forename: Mahesh
authors.initials: M
authors.lastname: Bajaj
authors.affiliation: Reader, Department of Prosthodontics, Sri Sai College of Dental Surgery , Vikarabad, Telangana, India .
authors.forename: Abhishek Savir
authors.initials: AS
authors.lastname: Math
authors.affiliation: Principal and Professor, Department of Periodontics, S.D.M. College of Dental Sciences and Hospital , Dharwad, Karnataka, India .
authors.forename: Srinath L
authors.initials: SL
authors.lastname: Thakur
keywords: Adipokines; Biomarkers; Gingival crevicular fluid; Glycated haemoglobin; Periodontal disease