title: Clinical outcome of 2nd generation cryoballoon pulmonary vein isolation in patients over 75 years of age.
abstract: Pulmonary vein isolation is an established therapy for symptomatic atrial fibrillation. Despite the fact that incidence and prevalence of atrial fibrillation increases with age, patients over 75 years of age have been excluded in all major atrial fibrillation ablation trials. Pulmonary vein isolation with the cryoballoon has been shown to be equally effective compared to irrigated radiofrequency catheter ablation, but patients over 75 years have also been excluded. The 2nd generation cryoballoon has shown superior efficacy compared to the 1st generation cryoballoon. The aim of the study was to assess the efficacy of pulmonary vein isolation with the 2nd generation cryoballoon for symptomatic atrial fibrillation in elderly patients over 75 years.
  
  
  
  Patients over 75 years of age presenting with symptomatic paroxysmal or persistent atrial fibrillation refractory or intolerant to at least one class I or class III antiarrhythmic drug who underwent pulmonary vein isolation with the 2nd generation cryoballoon were included in this single-center observational study.
  
  
  
  A total of 40 patients with a mean age of 78.3±2.7 years with paroxysmal (n=31; 77.5%) or persistent (n=9; 22.5%) atrial fibrillation were identified. All patients had a successful pulmonary vein isolation procedure with 100% of veins isolated. After a 3-month blanking period during a mean follow-up of 15.1±8.2 months there were 9 (22.5%) arrhythmia recurrences, while 31 patients (77.5%) maintained stable sinus rhythm. Freedom from arrhythmia recurrence was 86.4% at 12 months and 80.2% at 24 months.
  
  
  
  Pulmonary vein isolation with the 2nd generation cryoballoon appears to be an effective treatment for symptomatic atrial fibrillation also in patients over 75 years of age.
authors.affiliation: Department of Medicine II, Ulm University Medical Center, Ulm, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Pott
authors.affiliation: Department of Medicine II, Ulm University Medical Center, Ulm, Germany.
authors.forename: Marvin
authors.initials: M
authors.lastname: Messemer
authors.affiliation: Department of Medicine II, Ulm University Medical Center, Ulm, Germany.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Petscher
authors.affiliation: Department of Medicine II, Ulm University Medical Center, Ulm, Germany.
authors.forename: Mario
authors.initials: M
authors.lastname: Iturbe-Orbe
authors.affiliation: Department of Medicine II, Ulm University Medical Center, Ulm, Germany.
authors.forename: Carlo
authors.initials: C
authors.lastname: Bothner
authors.affiliation: Department of Medicine II, Ulm University Medical Center, Ulm, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Rottbauer
authors.affiliation: Department of Medicine II, Ulm University Medical Center, Ulm, Germany. Electronic address: tillman.dahme@uniklinik-ulm.de.
authors.forename: Tillman
authors.initials: T
authors.lastname: Dahme
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000188:drug therapy / Q000601:surgery*; D003452:Cryosurgery / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D011667:Pulmonary Veins / Q000601:surgery*; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D000889:Anti-Arrhythmia Agents
keywords: Ablation; Atrial fibrillation; Cryoballoon; Elderly