title: C-H Phosphonation of Pyrrolopyrimidines: Synthesis of Substituted 7- and 9-Deazapurine-8-phosphonate Derivatives.
abstract: The Mn(OAc)3-promoted C-H phosphonation of 7-deazapurines (pyrrolo[2,3-d]pyrimidines) and 9-deazapurines (pyrrolo[3,2-d]pyrimidines) with diethylphosphite was developed. The reactions occur regioselectively at position 8 both in 7 and 9-deazapurines, leading to new deazapurine-8-phosphonate derivatives, which can be further modified and transformed to 6-(het)aryl-deazapurine derivatives or deprotected to free phosphonic acids.
authors.affiliation: Department of Organic Chemistry, Faculty of Science, Charles University in Prague , Hlavova 8, 12843, Prague-2, Czech Republic.|Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Gilead & IOCB Research Center , Flemingovo nám. 2, 16610, Prague-6, Czech Republic.
authors.forename: Nazarii
authors.initials: N
authors.lastname: Sabat
authors.affiliation: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Gilead & IOCB Research Center , Flemingovo nám. 2, 16610, Prague-6, Czech Republic.
authors.forename: Lenka
authors.initials: L
authors.lastname: Poštová Slavětínská
authors.affiliation: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Gilead & IOCB Research Center , Flemingovo nám. 2, 16610, Prague-6, Czech Republic.
authors.forename: Blanka
authors.initials: B
authors.lastname: Klepetářová
authors.affiliation: Department of Organic Chemistry, Faculty of Science, Charles University in Prague , Hlavova 8, 12843, Prague-2, Czech Republic.|Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Gilead & IOCB Research Center , Flemingovo nám. 2, 16610, Prague-6, Czech Republic.
authors.forename: Michal
authors.initials: M
authors.lastname: Hocek