title: Survivin, a Promising Gene for Targeted Cancer Treatment.
abstract: Drawbacks of conventional cancer treatments, with lack of specificity and cytotoxicity using current approaches, underlies the necessity for development of a novel approach, gene-directed cancer therapy. This has provided novel technological opportunities in vitro and in vivo. This review focuses on a member of an apoptosis inhibitor family, survivin, as a valuable target. Not only the gene but also its promoter are applicable in this context. This article is based on a literature survey, with especial attention to RNA interference as well as tumor- specific promoter action. The search engine and databases utilized were Science direct, PubMed, MEDLINE and Google. In addition to cell-cycle modulation, apoptosis inhibition, interaction in cell-signaling pathways, cancer-selective expression, survivin also may be considered as specific target through its promoter as a novel treatment for cancer. Our purpose in writing this article was to create awareness in researchers, emphasizing relation of survivin gene expression to potential cancer treatment. The principal result and major conclusion of this manuscript are that survivin structure, biological functions and applications of RNA interference systems as well as tumor-specific promoter activity are of major interest for cancer gene therapy.
authors.affiliation: Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran E-mail : shahbazimajid@ yahoo.co.uk, mrakbari201177@yahoo.com.
authors.forename: Fatemeh T
authors.initials: FT
authors.lastname: Shamsabadi
authors.forename: Mohammad Reza Akbari
authors.initials: MR
authors.lastname: Eidgahi
authors.forename: Parvaneh
authors.initials: P
authors.lastname: Mehrbod
authors.forename: Nasibeh
authors.initials: N
authors.lastname: Daneshvar
authors.forename: Zeenathul Nazariah
authors.initials: ZN
authors.lastname: Allaudin
authors.forename: Ahad
authors.initials: A
authors.lastname: Yamchi
authors.forename: Majid
authors.initials: M
authors.lastname: Shahbazi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects / Q000235:genetics; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000235:genetics*; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000187:drug effects / Q000235:genetics; D034622:RNA Interference / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D051034:Inhibitor of Apoptosis Proteins