title: Preparation of enteric-coated microcapsules of astaxanthin oleoresin by complex coacervation.
abstract: Astaxanthin oleoresin (AO) has a number of beneficial physiological functions. However, its sensitivity to light, heat, oxygen and gastric fluids has limited its application. In this paper, we describe the preparation of AO enteric microcapsules by coacervation to improve its stability and enteric solubility, and evaluate their efficacy by measuring the drug loading, encapsulation efficiency, optical microscopic appearance, stability, in vitro release and bioavailability. The results obtained showed that the AO enteric microcapsules possessed a high encapsulation efficiency (85.9%), a satisfactory in vitro release profile, and the ability of the microencapsulated AO to resist the effects of light, heat and oxygen was improved by 2.2-fold, 3.1-fold and 2.4-fold, respectively, during storage. In addition, the bioavailability of AO microcapsules was approximately 1.29-fold higher than AO, which is important for pharmaceutical applications and as a functional food.
authors.affiliation: a School of Pharmacy Engineering , Shenyang Pharmaceutical University , Shenyang , PR China.
authors.forename: Rongli
authors.initials: R
authors.lastname: Li
authors.affiliation: a School of Pharmacy Engineering , Shenyang Pharmaceutical University , Shenyang , PR China.
authors.forename: Rencai
authors.initials: R
authors.lastname: Chen
authors.affiliation: a School of Pharmacy Engineering , Shenyang Pharmaceutical University , Shenyang , PR China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Liu
authors.affiliation: a School of Pharmacy Engineering , Shenyang Pharmaceutical University , Shenyang , PR China.
authors.forename: Cuiying
authors.initials: C
authors.lastname: Qin
authors.affiliation: a School of Pharmacy Engineering , Shenyang Pharmaceutical University , Shenyang , PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Han
mesh_terms: D000464:Alginates / Q000737:chemistry*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D002214:Capsules / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D004355:Drug Stability; D045703:Emulsifying Agents / Q000737:chemistry; D005780:Gelatin / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D017207:Rats, Sprague-Dawley; D024341:Xanthophylls / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D000464:Alginates; D000975:Antioxidants; D002214:Capsules; D004337:Drug Carriers; D045703:Emulsifying Agents; D006603:Hexuronic Acids; D010936:Plant Extracts; D024341:Xanthophylls; C018620:oleoresins; D020723:Glucuronic Acid; C005948:astaxanthine; D005780:Gelatin
keywords: Astaxanthin oleoresin; complex coacervation; enteric-coated microcapsules; in vitro release study; stability