title: Selenium attenuates apoptosis, inflammation and oxidative stress in the blood and brain of aged rats with scopolamine-induced dementia.
abstract: A potent antioxidant, selenium might modulate dementia-induced progression of brain and blood oxidative and apoptotic injuries. The present study explores whether selenium protects against experimental dementia (scopolamine, SCOP)-induced brain, and blood oxidative stress, apoptosis levels, and cytokine production in rats. Thirty-two rats were equally divided into four groups. The first group was used as an untreated control. The second group was treated with SCOP to induce dementia. The third and fourth groups received 1.5 mg/kg selenium (sodium selenite) and SCOP + selenium, respectively. Dementia was induced in the second and forth groups by intraperitoneal SCOP (1 mg/kg) administration. Brain, plasma, and erythrocyte lipid peroxidation levels as well as plasma TNF-α, interleukin (IL)-1β, and IL-4 levels were high in the SCOP group though they were low in selenium treatments. Selenium and selenium + SCOP treatments increased the lowered glutathione peroxidase activity, reduced glutathione, vitamins A and E concentrations in the brain, erythrocytes and plasma of the SCOP group. Apoptotic value expressions as active caspase-3, procaspase-9, and PARP were also increased by SCOP, while they were decreased by selenium and selenium + SCOP treatments. In conclusion, selenium induced protective effects against experimental dementia-induced brain, and blood oxidative injuries and apoptosis through regulation of cytokine production, vitamin E, glutathione concentrations, and glutathione peroxidase activity.
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
authors.forename: Kadir
authors.initials: K
authors.lastname: Demirci
authors.affiliation: Department of Neuroscience, Institute of Health Science, Suleyman Demirel University, Isparta, Turkey. mustafanaziroglu@sdu.edu.tr.|Neuroscience Research Center, University of Suleyman Demirel, -32260, Isparta, TR, Turkey. mustafanaziroglu@sdu.edu.tr.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Nazıroğlu
authors.affiliation: Department of Neuroscience, Institute of Health Science, Suleyman Demirel University, Isparta, Turkey.
authors.forename: İshak Suat
authors.initials: İS
authors.lastname: Övey
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Balaban
mesh_terms: D000375:Aging / Q000473:pathology; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects*; D016207:Cytokines / Q000378:metabolism; D003704:Dementia / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D004660:Encephalitis / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy / Q000469:parasitology; D018727:Muscarinic Antagonists; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012601:Scopolamine; D012643:Selenium / Q000494:pharmacology* / Q000627:therapeutic use*; D014815:Vitamins / Q000378:metabolism
chemical_list: D000975:Antioxidants; D016207:Cytokines; D018727:Muscarinic Antagonists; D018696:Neuroprotective Agents; D014815:Vitamins; D012601:Scopolamine; D012643:Selenium
keywords: Antioxidants; Brain; Inflammation; Scopolamine; Selenium