title: Short-term esmolol attenuates remodeling of the thoracic aorta in hypertensive rats by decreasing concentrations of ADMA down-regulated by oxidative stress.
abstract: Esmolol produces early regression of left ventricular hypertrophy and improves coronary artery remodeling, although the impact of short-term treatment with this beta-blocker on remodeling in large arteries has not yet been studied. We hypothesized that even a short (48h) course of esmolol might alter remodeling of the aorta in the spontaneously hypertensive rat (SHR). Fourteen-month-old male SHRs were treated intravenously with vehicle (SHR, n=8) or esmolol (SHR-E, n=8) (300μg/kg/min). Age-matched, vehicle-treated male Wistar-Kyoto rats (WKY, n=8) served as controls. After 48h, we studied the structure, volume density of elastic fibers, and passive mechanical properties of the aorta. Determination of asymmetrical dimethylarginine concentrations and total protein carbonyls in the aorta were analyzed. Esmolol significantly attenuated abnormal aortic wall thickness, cross-sectional area, wall-to-lumen ratio, volume density of elastic fibers, and wall stiffness. The protective effect of esmolol could be related to a decrease in asymmetrical dimethylarginine levels after down-regulation by oxidative stress. These findings could play a key role in the selection of antihypertensive therapy in patients with hypertension and aortic remodeling.
authors.affiliation: Department of Anesthesiology, Hospital Gregorio Marañón, Health Research Institute of Hospital Gregorio Marañón, 28007 Madrid, Spain. Electronic address: begoquinti@gmail.com.
authors.forename: Begoña
authors.initials: B
authors.lastname: Quintana-Villamandos
authors.affiliation: Department of Physiology Faculty of Medicine, Universidad Autónoma de Madrid, 28029 Madrid, Spain. Electronic address: m.c.gonzalez@uam.es.
authors.forename: María Carmen
authors.initials: MC
authors.lastname: González
authors.affiliation: Molecular Biology Laboratory, Department Experimental Medicine and Surgery, Hospital Gregorio Marañón, Health Research Institute of Hospital Gregorio Marañón, 28007 Madrid, Spain. Electronic address: mj.delgadomartos@gmail.com.
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Delgado-Martos
authors.affiliation: Department of Physiology Faculty of Medicine, Universidad Autónoma de Madrid, 28029 Madrid, Spain. Electronic address: lcondezotm@hotmail.com.
authors.forename: Luis
authors.initials: L
authors.lastname: Condezo-Hoyos
authors.affiliation: Department of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. Electronic address: boeger@uke.uni-hamburg.de.
authors.forename: Rainer H
authors.initials: RH
authors.lastname: Böger
authors.affiliation: Department of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. Electronic address: n.lueneburg@uke.de.
authors.forename: Nicole
authors.initials: N
authors.lastname: Lüneburg
authors.affiliation: Department of Anesthesiology, Hospital Gregorio Marañón, Health Research Institute of Hospital Gregorio Marañón, 28007 Madrid, Spain. Electronic address: lpazosay8@gmail.com.
authors.forename: Laia
authors.initials: L
authors.lastname: Pazó-Sayós
authors.affiliation: Department of Physiology Faculty of Medicine, Universidad Autónoma de Madrid, 28029 Madrid, Spain. Electronic address: pela.gutierrez@gmail.com.
authors.forename: Perla Yareli
authors.initials: PY
authors.lastname: Gutiérrez-Arzapalo
authors.affiliation: Molecular Biology Laboratory, Department Experimental Medicine and Surgery, Hospital Gregorio Marañón, Health Research Institute of Hospital Gregorio Marañón, 28007 Madrid, Spain. Electronic address: delgadobaeza@gmail.com.
authors.forename: Emilio
authors.initials: E
authors.lastname: Delgado-Baeza
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects* / Q000473:pathology* / Q000503:physiopathology; D001120:Arginine / Q000031:analogs & derivatives* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D015536:Down-Regulation / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D011412:Propanolamines / Q000494:pharmacology*; D050050:Protein Carbonylation / Q000187:drug effects; D051381:Rats; D011918:Rats, Inbred SHR; D013718:Tensile Strength / Q000187:drug effects; D066253:Vascular Remodeling / Q000187:drug effects*
chemical_list: D011412:Propanolamines; C018524:N,N-dimethylarginine; D001120:Arginine; C036604:esmolol
keywords: Aorta; Asymmetrical dimethylarginine; Esmolol; Hypertension; Spontaneously hypertensive rats; Vascular remodeling