title: Integrating a Rapid Diagnostic Test and Antimicrobial Stewardship: Optimizing Discharge Antibiotics in Skin and Soft Tissue Infections.
abstract: A rapid test to detect methicillin resistance in Staphylococcus aureus through the penicillin-binding protein 2a antigen was introduced for pediatric patients hospitalized for purulent skin and soft tissue infections. Integration of this test with physician education and stewardship guidance improved targeted antibiotic use for infections caused by methicillin-susceptible S. aureus (44%-80%, P < 0.001), including when final culture results were not available.
authors.affiliation: From the *Department of Pharmacy, Children's Mercy Hospital, Kansas City, Missouri; †Department of Pharmacy; Ann and Robert H. Lurie Children's Hospital, Chicago, Illinois ‡Department of Pediatrics, Children's Mercy Hospital, Kansas City, Missouri, and §Division of Laboratory Medicine, Children's Mercy Hospital, Kansas City, Missouri.
authors.forename: Diana
authors.initials: D
authors.lastname: Yu
authors.forename: Leslie
authors.initials: L
authors.lastname: Stach
authors.forename: Jason G
authors.initials: JG
authors.lastname: Newland
authors.forename: Rangaraj
authors.initials: R
authors.lastname: Selvarangan
authors.forename: Jennifer
authors.initials: J
authors.lastname: Goldman
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D015373:Bacterial Typing Techniques / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification*; D046915:Penicillin-Binding Proteins; D010607:Pharmacy Service, Hospital; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity; D013207:Staphylococcal Skin Infections / Q000175:diagnosis* / Q000188:drug therapy* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000302:isolation & purification*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D046915:Penicillin-Binding Proteins; D011933:Reagent Kits, Diagnostic