title: Infective endocarditis after device closure of atrial septal defects: Case report and review of the literature.
abstract: We report a case of late infective endocarditis in an 8-year-old boy 3 years after transcatheter closure of an atrial septal defect with the Amplatzer Atrial Septal Occluder Device. Echocardiography showed a very thick pannus lining the left atrial disc of the prosthesis, with some mobile elements. MRI showed several cerebral microemboli. The patient had dental caries and blood cultures found Staphylococcus aureus. Patient was treated with gentamicin and oxacillin before surgical removal of the prosthesis. Twenty-one cases of infective endocarditis after atrial defect device closure have been reported in the literature (13 ostium secundum ASD and 8 patent foramen ovale). Seven pediatric cases were reported. S. aureus was the most frequent bacterium. Antibiotics were administered in all cases and most patients (n = 18) underwent surgical removal of the device. Incomplete endothelialization of the prosthesis was a suggested mechanism. Two patients died after surgery. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Pediatric and Congenital Cardiology Department, M3C Regional Center, University Hospital, Montpellier, France.|Physiology and Experimental Biology of Heart and Muscles Laboratory - PHYMEDEXP, UMR CNRS 9214 - INSERM U1046, Montpellier, France.
authors.forename: Pascal
authors.identifier: http://orcid.org/0000-0003-3649-0294
authors.initials: P
authors.lastname: Amedro
authors.affiliation: Pediatric and Congenital Cardiology Department, M3C Regional Center, University Hospital, Montpellier, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Soulatges
authors.affiliation: Pediatric Cardiology Service, Royal Brompton and Harefield Hospital Trust, London, United Kingdom.
authors.forename: Alain
authors.initials: A
authors.lastname: Fraisse
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D006328:Cardiac Catheterization / Q000009:adverse effects* / Q000295:instrumentation; D002648:Child; D020878:Device Removal; D004452:Echocardiography; D004697:Endocarditis, Bacterial / Q000175:diagnosis / Q000382:microbiology* / Q000601:surgery; D006344:Heart Septal Defects, Atrial / Q000000981:diagnostic imaging / Q000628:therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D016459:Prosthesis-Related Infections / Q000175:diagnosis / Q000382:microbiology* / Q000601:surgery; D012307:Risk Factors; D055989:Septal Occluder Device / Q000009:adverse effects*; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000382:microbiology* / Q000601:surgery; D013211:Staphylococcus aureus / Q000302:isolation & purification*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents
keywords: ASD; Amplatzer Atrial Septal Occluder Device; atrial septal defect; infective endocarditis; pediatrics