title: IgG4-related Disease Involving Multiple Organs with Elevated Serum Interleukin-6 Levels.
abstract: A 63-year-old woman presented to our hospital with elevated levels of serum IgG4, marked wall thickening of the gallbladder, hepatomegaly, and abdominal lymphadenopathy. She experienced a recurrent fever and leg edema. Her laboratory data demonstrated anemia, hypoalbuminemia, and elevated serum levels of interleukin-6 and C-reactive protein. The patient was eventually diagnosed with IgG4-related disease according to the comprehensive diagnostic criteria, although the patient exhibited common clinical manifestations of multicentric Castleman disease such as a fever, anemia, lymphadenopathy, and elevated levels of serum interleukin-6 and C-reactive protein. This case report highlights the difficulties in differentiating between these two diseases.
authors.affiliation: The Third Department of Internal Medicine, Kansai Medical University, Japan.
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Ikeura
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Horitani
authors.forename: Masataka
authors.initials: M
authors.lastname: Masuda
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kasai
authors.forename: Masato
authors.initials: M
authors.lastname: Yanagawa
authors.forename: Hideaki
authors.initials: H
authors.lastname: Miyoshi
authors.forename: Kazushige
authors.initials: K
authors.lastname: Uchida
authors.forename: Makoto
authors.initials: M
authors.lastname: Takaoka
authors.forename: Chika
authors.initials: C
authors.lastname: Miyasaka
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Uemura
authors.forename: Kazuichi
authors.initials: K
authors.lastname: Okazaki
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism; D005871:Castleman Disease / Q000097:blood / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006529:Hepatomegaly / Q000175:diagnosis; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D000072281:Lymphadenopathy / Q000175:diagnosis; D008232:Lymphoproliferative Disorders / Q000175:diagnosis; D008875:Middle Aged
chemical_list: C508600:IL6 protein, human; D007074:Immunoglobulin G; D015850:Interleukin-6; D002097:C-Reactive Protein