title: Immune and Pancreatic β Cell Interactions in Type 1 Diabetes.
abstract: The autoimmune destruction of the pancreatic islet β cells is due to a targeted lymphocyte attack. Different T cell subsets communicate with each other and with the insulin-producing β cells in this process, with evidence not only of damage to the tissue cells but also of lymphocyte regulation. Here we explore the various components of the immune response as well as the cellular interactions that are involved in causing or reducing immune damage to the β cells. We consider these in the light of the possibility that understanding them may help us identify therapeutic targets to reduce the damage and destruction leading to type 1 diabetes.
authors.affiliation: Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
authors.forename: Joanne
authors.initials: J
authors.lastname: Boldison
authors.affiliation: Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, UK. Electronic address: WongFS@Cardiff.ac.uk.
authors.forename: F Susan
authors.initials: FS
authors.lastname: Wong
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D050417:Insulin-Secreting Cells / Q000276:immunology / Q000378:metabolism*; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism
keywords: autoimmune disease; immune crosstalk; inflammation; pancreatic islets; type 1 diabetes