title: Association between age and overall survival of patients with hepatocellular carcinoma after hepatic resection.
abstract: OBJECTIVE
  The suitability of hepatic resection for older patients remains controversial. This study aimed to investigate whether age influences overall survival of patients with hepatocellular carcinoma (HCC) after resection.
  
  
  METHODS
  Records of 1,132 patients with HCC after hepatic resection were retrospectively reviewed. Overall survival (OS) was compared between younger and older patients based on five cut-off ages (30, 40, 50, 60, and 70 years).
  
  
  RESULTS
  Across all patients, OS was 89.7% at 1 year, 67.7% at 3 years, and 47.7% at 5 years. OS was similar between younger and older patients at all cut-off ages (all P > 0.1), but OS was marginally lower among patients >70 years old than those ≤70 (P = 0.090). Multivariate analyses identified several risk factors for lower OS: preoperative serum albumin <35 g/L, alanine aminotransferase >80 U/L, α-fetoprotein ≥400 ng/ml, presence of esophagogastric varices or macrovascular invasion, incomplete/absent tumor capsule, tumor size >10 cm, tumor number ≥3, and major hepatectomy.
  
  
  CONCLUSIONS
  Age does not influence the prognosis of patients with HCC after hepatic resection. Older patients should be considered for curative resection if remnant liver volume and liver function are adequate. J. Surg. Oncol. 2016;114:966-970. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Surgical Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, P.R. China.
authors.forename: Jun-Tao
authors.initials: JT
authors.lastname: Tan
authors.affiliation: Department of Surgical Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, P.R. China.
authors.forename: Chang
authors.initials: C
authors.lastname: Zhao
authors.affiliation: Department of Surgical Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, P.R. China.
authors.forename: Ning-Fu
authors.initials: NF
authors.lastname: Peng
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, P.R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Surgical Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, P.R. China.
authors.forename: Jian-Hong
authors.initials: JH
authors.lastname: Zhong
authors.affiliation: Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, P.R. China.
authors.forename: Tian
authors.initials: T
authors.lastname: Yang
authors.affiliation: Department of Hepatology, Liver Research Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, P.R. China.
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Zheng
authors.affiliation: Department of Surgical Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, P.R. China.
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Wang
authors.affiliation: Department of Surgical Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, P.R. China.
authors.forename: Wen-Feng
authors.initials: WF
authors.lastname: Gong
authors.affiliation: Department of Surgical Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, P.R. China.
authors.forename: Bang-De
authors.initials: BD
authors.lastname: Xiang
authors.affiliation: Department of Surgical Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, P.R. China.
authors.forename: Le-Qun
authors.initials: LQ
authors.lastname: Li
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis
keywords: age; hepatic resection; hepatocellular carcinoma; overall survival