title: Adenovirus Early Proteins and Host Sumoylation.
abstract: The human adenovirus genome is transported into the nucleus, where viral gene transcription, viral DNA replication, and virion assembly take place. Posttranslational modifications by small ubiquitin-like modifiers (SUMOs) are implicated in the regulation of diverse cellular processes, particularly nuclear events. It is not surprising, therefore, that adenovirus modulates and utilizes the host sumoylation system. Adenovirus early proteins play an important role in establishing optimal host environments for virus replication within infected cells by stimulating the cell cycle and counteracting host antiviral defenses. Here, we review findings on the mechanisms and functional consequences of the interplay between human adenovirus early proteins and the host sumoylation system.
authors.affiliation: Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, New York, USA.
authors.forename: Sook-Young
authors.initials: SY
authors.lastname: Sohn
authors.affiliation: Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, New York, USA patrick.hearing@stonybrook.edu.
authors.forename: Patrick
authors.initials: P
authors.lastname: Hearing
mesh_terms: D017456:Adenovirus Early Proteins / Q000235:genetics / Q000378:metabolism*; D000260:Adenoviruses, Human / Q000235:genetics / Q000502:physiology*; D002467:Cell Nucleus / Q000821:virology; D054884:Host-Pathogen Interactions; D006801:Humans; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism; D058207:Sumoylation; D025801:Ubiquitin / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism; D014779:Virus Replication
chemical_list: D017456:Adenovirus Early Proteins; D025841:Small Ubiquitin-Related Modifier Proteins; D025801:Ubiquitin; D014764:Viral Proteins