title: Shedding light on paraspeckle structure by super-resolution microscopy.
abstract: The nuclear body paraspeckle is built on the lncRNA Neat1 and plays important roles in gene regulation. In this issue, West et al. (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201601071) use super-resolution structured illumination microscopy to show that paraspeckles are organized in a core-shell spheroidal structure composed of Neat1 and seven proteins.
authors.affiliation: State Key Laboratory of Molecular Biology, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Shi-Bin
authors.initials: SB
authors.lastname: Hu
authors.affiliation: State Key Laboratory of Molecular Biology, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Run-Wen
authors.initials: RW
authors.lastname: Yao
authors.affiliation: State Key Laboratory of Molecular Biology, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China University of Chinese Academy of Sciences, Beijing 100049, China School of Life Science, ShanghaiTech University, Shanghai 200031, China linglingchen@sibcb.ac.cn.
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Chen
mesh_terms: D000818:Animals; D045586:Intranuclear Inclusion Bodies / Q000378:metabolism* / Q000648:ultrastructure; D008322:Mammals / Q000378:metabolism; D008853:Microscopy / Q000379:methods*; D062085:RNA, Long Noncoding / Q000235:genetics / Q000378:metabolism
chemical_list: D062085:RNA, Long Noncoding