title: Comparison of naproxen with cyclobenzaprine, oxycodone-acetaminophen, and placebo for the treatment of acute low back pain.
abstract: Clinical Question Does the addition of cyclobenzaprine or oxycodone with acetaminophen to naproxen result in improved functional outcomes at one week when compared to placebo in patients with acute low back pain? Article Chosen Friedman B, Dym A, Davitt, M, et al. Naproxen with cyclobenzaprine, oxycodone/acetaminophen, or placebo for treating acute low back pain: a randomized clinical trial. JAMA 2015:20;314(15):1572-80. Study Objective The primary objective of this study was to compare functional outcomes at one week and three months after emergency department (ED) presentation for acute low back pain among patients prescribed naproxen plus one of the following: (1) oxycodone/acetaminophen; (2) cyclobenzaprine; or (3) placebo.
authors.affiliation: *Department of Emergency Medicine,Rush UniversityMedical Center,Chicago,IL.
authors.forename: Michael
authors.initials: M
authors.lastname: Gottlieb
authors.affiliation: †Department of Emergency Medicine,Cook County (Stroger) Hospital,Chicago,IL.
authors.forename: Abdoulie
authors.initials: A
authors.lastname: Njie
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use*; D000208:Acute Disease; D000284:Administration, Oral; D000328:Adult; D000639:Amitriptyline / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004338:Drug Combinations; D004636:Emergency Service, Hospital; D005260:Female; D005500:Follow-Up Studies; D006784:Hospitals, Teaching; D006801:Humans; D017116:Low Back Pain / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009288:Naproxen / Q000627:therapeutic use*; D010098:Oxycodone / Q000627:therapeutic use*; D010147:Pain Measurement; D017060:Patient Satisfaction / Q000706:statistics & numerical data; D012720:Severity of Illness Index; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D004338:Drug Combinations; C514822:oxycodone-acetaminophen; D000639:Amitriptyline; D000082:Acetaminophen; D009288:Naproxen; C004704:cyclobenzaprine; D010098:Oxycodone
keywords: cyclobenzaprine; emergency department; low back pain; muscle relaxant; opioid; oxycodone