title: Structural biology of the macroautophagy machinery.
abstract: Macroautophagy is a conserved degradative process mediated through formation of a unique double-membrane structure, the autophagosome. The discovery of autophagy-related (Atg) genes required for autophagosome formation has led to the characterization of approximately 20 genes mediating this process. Recent structural studies of the Atg proteins have provided the molecular basis for their function. Here we summarize the recent progress in elucidating the structural basis for autophagosome formation.
authors.affiliation: Department of Biochemistry and Molecular Biology, The University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada.
authors.forename: Leon H
authors.initials: LH
authors.lastname: Chew
authors.affiliation: Department of Biochemistry and Molecular Biology, The University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada.
authors.forename: Calvin K
authors.initials: CK
authors.lastname: Yip
keywords: Atg proteins; X-ray crystallography; autophagy; macroautophagy; single-particle electron microscopy; structural biology