title: Liposome encapsulated perfluorohexane enhances radiotherapy in mice without additional oxygen supply.
abstract: To investigate the effect of perfluorochemical preparations in enhancing radiotherapy, perfluocarbon nanoparticles were by encapsulating perfluorohexane into liposome [lip(PFH)].
  
  
  
  After intravenous injection, lip(PFH) could accumulate in the tumor site over time, with a prominent accumulation in tumor 24 h post injection. X-ray was delivered to the tumor site 24 h after the injection of lip(PFH) under room air. The experimental mice were randomized into four groups: control (saline), lip(PFH) (lip(PFH) only), X-ray (X-ray only), and lip(PFH) + X-ray (lip(PFH) with X-ray radiation). Tumor volume and histology were monitored to assess treatment efficacy.
  
  
  
  Tumor growth was significantly reduced in mice received lip(PFH) and X-ray compared with X-ray only. The histological data also revealed more destruction of tumor tissue in lip(PFH) + X-ray group compared with X-ray only. In addition, lip(PFH) did not show any significant tissue damage to major organs or induce significant liver/kidney dysfunction.
  
  
  
  Lip(PFH) could accumulate in the tumor site and enhance radiotherapy without additional oxygen supply.
authors.affiliation: Department of Uroloågy, Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, 210008, China.|State Key Laboratory of Pharmaceutical Biotechnology, School of Medicine, Nanjing University, Nanjing, 210093, China.|Institute of Urology, Nanjing University, Nanjing, 210008, China.
authors.forename: Linfeng
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Uroloågy, Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, 210008, China.|State Key Laboratory of Pharmaceutical Biotechnology, School of Medicine, Nanjing University, Nanjing, 210093, China.|Institute of Urology, Nanjing University, Nanjing, 210008, China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Qiu
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Medicine, Nanjing University, Nanjing, 210093, China.
authors.forename: Yanting
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Uroloågy, Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, 210008, China.|State Key Laboratory of Pharmaceutical Biotechnology, School of Medicine, Nanjing University, Nanjing, 210093, China.|Institute of Urology, Nanjing University, Nanjing, 210008, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Cao
authors.affiliation: Department of Uroloågy, Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, 210008, China.|Institute of Urology, Nanjing University, Nanjing, 210008, China.
authors.forename: Xiaozhi
authors.initials: X
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Medicine, Nanjing University, Nanjing, 210093, China. wuj@nju.edu.cn.
authors.forename: Jinhui
authors.initials: J
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Medicine, Nanjing University, Nanjing, 210093, China. huyiqiao@nju.edu.cn.
authors.forename: Yiqiao
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Uroloågy, Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, 210008, China. dr.guohongqian@gmail.com.|Institute of Urology, Nanjing University, Nanjing, 210008, China. dr.guohongqian@gmail.com.
authors.forename: Hongqian
authors.initials: H
authors.lastname: Guo
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003110:Colonic Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D005466:Fluorocarbons / Q000494:pharmacology* / Q000633:toxicity; D007677:Kidney Function Tests; D008081:Liposomes / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D053758:Nanoparticles / Q000737:chemistry*; D010100:Oxygen / Q000494:pharmacology*; D011836:Radiation Tolerance / Q000187:drug effects
chemical_list: D015415:Biomarkers; D005466:Fluorocarbons; D008081:Liposomes; C078626:perflexane; D010100:Oxygen
keywords: Accumulation; Nanoparticles; Oxygen supply; Perfluorocarbon; Perfluorohexane; Radiosensitization