title: Increased Proinflammatory Responses of Monocytes and Plasmacytoid Dendritic Cells to Influenza A Virus Infection During Pregnancy.
abstract: Pregnancy-induced alterations in immunity may contribute to the increased morbidity associated with influenza A virus infection during pregnancy. We characterized the immune response of monocytes and plasmacytoid dendritic cells (pDCs) to influenza A virus infection in 21 pregnant and 21 nonpregnant women. In pregnant women, monocytes and pDCs exhibit an exaggerated proinflammatory immune response to 2 strains of influenza A virus, compared with nonpregnant women, characterized by increased expression of major histocompatibility complex class II (approximately 2.0-fold), CD69 (approximately 2.2-fold), interferon γ-induced protein 10 (approximately 2.0-fold), and macrophage inflammatory protein 1β (approximately 1.5-fold). This enhanced innate inflammatory response during pregnancy could contribute to pulmonary inflammation following influenza A virus infection.
authors.affiliation: Department of Medicine.|Stanford Immunology.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Le Gars
authors.affiliation: Department of Pediatrics.
authors.forename: Alexander W
authors.initials: AW
authors.lastname: Kay
authors.affiliation: Stanford Immunology.
authors.forename: Nicholas L
authors.initials: NL
authors.lastname: Bayless
authors.affiliation: Department of Obstetrics and Gynecology.
authors.forename: Natali
authors.initials: N
authors.lastname: Aziz
authors.affiliation: Department of Pediatrics.
authors.forename: Cornelia L
authors.initials: CL
authors.lastname: Dekker
authors.affiliation: Stanford Prevention Research Center.
authors.forename: Gary E
authors.initials: GE
authors.lastname: Swan
authors.affiliation: Howard Hughes Medical Institute.|Department of Microbiology and Immunology, Stanford University School of Medicine, California.
authors.forename: Mark M
authors.initials: MM
authors.lastname: Davis
authors.affiliation: Department of Medicine.|Stanford Immunology.
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Blish
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D054407:Chemokine CCL4 / Q000032:analysis; D054357:Chemokine CXCL10 / Q000032:analysis; D016207:Cytokines / Q000378:metabolism*; D003713:Dendritic Cells / Q000276:immunology* / Q000821:virology*; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D009980:Influenza A virus / Q000276:immunology*; D037181:Lectins, C-Type / Q000032:analysis; D009000:Monocytes / Q000276:immunology* / Q000821:virology*; D011247:Pregnancy; D055815:Young Adult; D000099192:CD69 Antigens
chemical_list: D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D054407:Chemokine CCL4; D054357:Chemokine CXCL10; D016207:Cytokines; D000949:Histocompatibility Antigens Class II; D037181:Lectins, C-Type; D000099192:CD69 Antigens
keywords: influenza virus; innate immunity; monocytes; plasmacytoid dendritic cells; pregnancy