title: Vascular smooth muscle cell dysfunction in diabetes: nuclear receptors channel to relaxation.
abstract: Endothelial dysfunction and impaired vascular relaxation represent a common cause of microvascular disease in patients with diabetes. Although multiple mechanisms underlying altered endothelial cell function in diabetes have been described, there is currently no specific and approved pharmacological treatment. In this edition of Clinical Science, Morales-Cano et al. characterize voltage-dependent K(+) (Kv) channels as genes regulated by pharmacological activation of peroxisome proliferator-activated receptor-b/d (PPARb/d). Diabetes altered Kv channel function leading to impaired coronary artery relaxation, which was prevented by pharmacological activation of PPARb/d. These studies highlight an important mechanism of vascular dysfunction in diabetes and point to a potential approach for therapy, particularly considering that PPARb/d ligands have been developed and tested in small clinical trials.
authors.affiliation: Division of Cardiology, Department of Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, UPMC and University of Pittsburgh School of Medicine Pittsburgh, PA 15261, U.S.A.
authors.forename: Geneviève
authors.initials: G
authors.lastname: Doyon
authors.affiliation: Division of Cardiology, Department of Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, UPMC and University of Pittsburgh School of Medicine Pittsburgh, PA 15261, U.S.A. bruemmerd@upmc.edu.
authors.forename: Dennis
authors.initials: D
authors.lastname: Bruemmer
mesh_terms: D000818:Animals; D003331:Coronary Vessels / Q000503:physiopathology; D003920:Diabetes Mellitus / Q000235:genetics / Q000378:metabolism; D058065:Diabetic Cardiomyopathies / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D042783:Endothelial Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D014664:Vasodilation
chemical_list: D018160:Receptors, Cytoplasmic and Nuclear