title: Pancreatic mucinous cystadenocarcinoma: Epidemiology and outcomes.
abstract: BACKGROUND
  Pancreatic mucinous cystadenocarcinoma is a rare malignancy. Our aim was to investigate the demographic, pathological characteristics, treatment modalities and survival of patients with mucinous cystadenocarcinoma via the National Cancer Institute's Surveillance Epidemiology and End Results (SEER) database analysis.
  
  
  METHODS
  This was a retrospective study of SEER database's records on patients with mucinous cystadenocarcinoma diagnosed from 1988 to 2012. Primary outcome measures were clinico-pathological characteristics, observed and disease-specific survival.
  
  
  RESULTS
  A total of 507 patients were identified. Median age at diagnosis was 67 years and most patients were female (68.4%). The tumors were mainly low grade (82.9%, grade I-II) and frequently localized (42.8%) in the body/tail of the pancreas (45.6%). According to Kaplan-Meier curves observed survival was 111 months (95%CI: 82.5, 139.5) vs 14 months (95% CI: 10.9, 17.1) vs 4 months (95%CI: 2.9, 5.1) for patients with localized, regional and distant disease, respectively. One-year disease-specific survival for patients with localized disease was 90.1%, vs. 56.7% for those with regional and 18.7% with distant tumor spread.
  
  
  CONCLUSIONS
  Mucinous cystadenocarcinomas tend to be low grade tumors, localized to the pancreatic body/tail. Surgery as the primary therapeutic intervention and tumor stage are independent predictors of disease-specific survival.
authors.affiliation: Society of Junior Doctors, Athens, Greece.
authors.forename: Ilias P
authors.initials: IP
authors.lastname: Doulamis
authors.affiliation: Society of Junior Doctors, Athens, Greece; Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Konstantinos S
authors.initials: KS
authors.lastname: Mylonas
authors.affiliation: Society of Junior Doctors, Athens, Greece; Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.
authors.forename: Christos E
authors.initials: CE
authors.lastname: Kalfountzos
authors.affiliation: Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Danny
authors.initials: D
authors.lastname: Mou
authors.affiliation: Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
authors.forename: Huzaifa
authors.initials: H
authors.lastname: Haj-Ibrahim
authors.affiliation: Society of Junior Doctors, Athens, Greece. Electronic address: dnasioudis@sni.gr.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Nasioudis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018282:Cystadenocarcinoma, Mucinous / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D011379:Prognosis; D012189:Retrospective Studies; D018426:SEER Program; D016019:Survival Analysis; D014481:United States / Q000453:epidemiology; D055815:Young Adult
keywords: Mucinous cystadenocarcinoma; Neoplasms; Pancreas