title: MicroRNA-1284 inhibits proliferation and induces apoptosis in SGC-7901 human gastric cancer cells.
abstract: OBJECTIVE
  To explore the functional effects of miR-1284 on gastric cancer cells.
  
  
  RESULTS
  Overexpression of miR-1284 significantly reduced SGC-7901 cell proliferation, but improved apoptosis. However, miR-1284 suppression displayed the inversed impacts. Furthermore, the protein levels of p27, Bax, procaspase-3 and active caspase-3 were up-regulated by miR-1284 overexpression, but were down-regulated by miR-1284 suppression. The level of Bcl-2 was down-regulated by miR-1284 overexpression, while it was up-regulated by miR-1284 suppression. The level of p21 was unaffected.
  
  
  CONCLUSIONS
  These results suggest that miR-1284 overexpression might be a suppressor for gastric cancer via controlling of cell proliferation and apoptosis.
authors.affiliation: Department of Gastrointestinal Surgery, Affiliated Tumor Hospital of Guangxi Medical University, No.71 Hedi Road, Nanning, 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Mingwei
authors.initials: M
authors.lastname: Huang
authors.affiliation: Department of Gastrointestinal Surgery, Affiliated Tumor Hospital of Guangxi Medical University, No.71 Hedi Road, Nanning, 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Liucheng
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Gastrointestinal Surgery, Affiliated Tumor Hospital of Guangxi Medical University, No.71 Hedi Road, Nanning, 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Luo
authors.affiliation: Department of Gastrointestinal Surgery, Affiliated Tumor Hospital of Guangxi Medical University, No.71 Hedi Road, Nanning, 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Haiquan
authors.initials: H
authors.lastname: Qin
authors.affiliation: Department of Gastrointestinal Surgery, Affiliated Tumor Hospital of Guangxi Medical University, No.71 Hedi Road, Nanning, 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Gastrointestinal Surgery, Affiliated Tumor Hospital of Guangxi Medical University, No.71 Hedi Road, Nanning, 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Jiansi
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Gastrointestinal Surgery, Affiliated Tumor Hospital of Guangxi Medical University, No.71 Hedi Road, Nanning, 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Gastrointestinal Surgery, Affiliated Tumor Hospital of Guangxi Medical University, No.71 Hedi Road, Nanning, 530021, Guangxi Zhuang Autonomous Region, China. qinyuzhou1065@126.com.
authors.forename: Yuzhou
authors.initials: Y
authors.lastname: Qin
mesh_terms: D017209:Apoptosis / Q000235:genetics / Q000502:physiology*; D053148:Caspase 3 / Q000378:metabolism; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000235:genetics / Q000502:physiology*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics / Q000502:physiology; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000502:physiology*; D013274:Stomach Neoplasms / Q000235:genetics* / Q000378:metabolism
chemical_list: C000613155:MIRN1284 microRNA, human; D035683:MicroRNAs; D053148:Caspase 3
keywords: Apoptosis; Cell proliferation; Gastric cancer; SGC-7901 cells; miR-1284