title: The Combination Therapy of Dissolution Using Carbonated Liquid and Endoscopic Procedure for Bezoars: Pragmatical and Clinical Review.
abstract: Bezoars are relatively rare foreign bodies of gastrointestinal tract and often cause ileus and ulcerative lesions in the stomach and subsequent bleeding and perforation due to their size and stiffness. Therefore, the removal of bezoars is essential and recent development of devices, the endoscopic removal procedure, is often applied. However, due to their stiffness, simple endoscopic removal failed in not a few cases, and surgical removal has also been used. Recently, the efficacy of a combination therapy of endoscopic procedure and dissolution using carbonated liquid has been reported. To develop the safe and effective removal procedure, we carefully reviewed a total of 55 reported cases in this study including our 3 additional cases, successfully treated with dissolution with endoscopic fragmentation. In summary, the data showed the efficiency in the combination therapy, treating the larger size of bezoar and reducing the length of hospital stay. To the best of our knowledge, this is the largest pragmatical and clinical review for the combination therapy of dissolution and endoscopic treatment for bezoars. This review should help physicians to manage bezoars more efficiently.
authors.affiliation: Division of Gastroenterology and Hepatology, Graduate School of Medical Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan.
authors.forename: Kohei
authors.initials: K
authors.lastname: Ogawa
authors.affiliation: Division of Gastroenterology and Hepatology, Graduate School of Medical Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan.
authors.forename: Kenya
authors.identifier: 0000-0001-7182-4400
authors.initials: K
authors.lastname: Kamimura
authors.affiliation: Division of Gastroenterology and Hepatology, Graduate School of Medical Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan.
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Mizuno
authors.affiliation: Division of Gastroenterology and Hepatology, Graduate School of Medical Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Shinagawa
authors.affiliation: Division of Gastroenterology and Hepatology, Graduate School of Medical Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kobayashi
authors.affiliation: Division of Gastroenterology and Hepatology, Graduate School of Medical Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Abe
authors.affiliation: Division of Gastroenterology and Hepatology, Graduate School of Medical Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan.
authors.forename: Yukari
authors.initials: Y
authors.lastname: Watanabe
authors.affiliation: Division of Gastroenterology and Hepatology, Graduate School of Medical Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan.
authors.forename: Shunsaku
authors.initials: S
authors.lastname: Takahashi
authors.affiliation: Division of Gastroenterology and Hepatology, Graduate School of Medical Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan.
authors.forename: Kazunao
authors.initials: K
authors.lastname: Hayashi
authors.affiliation: Division of Gastroenterology and Hepatology, Graduate School of Medical Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan.
authors.forename: Junji
authors.initials: J
authors.lastname: Yokoyama
authors.affiliation: Division of Gastroenterology and Hepatology, Graduate School of Medical Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Takeuchi
authors.affiliation: Division of Gastroenterology and Hepatology, Graduate School of Medical Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan.
authors.forename: Masaaki
authors.identifier: 0000-0003-4053-3402
authors.initials: M
authors.lastname: Kobayashi
authors.affiliation: Division of Gastroenterology and Hepatology, Graduate School of Medical Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamagiwa
authors.affiliation: Division of Gastroenterology and Hepatology, Graduate School of Medical Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Sato
authors.affiliation: Division of Gastroenterology and Hepatology, Graduate School of Medical Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan.
authors.forename: Shuji
authors.initials: S
authors.lastname: Terai