title: [Multi-Line Chemotherapy for Metastatic Colorectal Cancer].
abstract: We administered multi-line chemotherapy(ie, more than fifth-line chemotherapy)to 5 patients with metastatic colorectal cancer(age range, 62to 78 years; median age, 68years). Four of the five patients died because of cancer progression; however, the mean overall survival(OS)was 39 months. In our experience, re-challenging with key drugs was associated with clinical benefits. A case that could be thrown until ninth-line treatment was also experienced. A strategy based on rechallenging and changes in the combination of key drugs[5-FU-based chemotherapy, oxaliplatin, irinotecan(CPT-11), bevacizumab(Bmab)and panitumumab(Pmab)]may prolong life and offer new hope for these patients.
authors.affiliation: Dept. of Surgery, Goushi Hospital.
authors.forename: Masanobu
authors.initials: M
authors.lastname: Terakura
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Mayumi
authors.forename: Masashi
authors.initials: M
authors.lastname: Takemura
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016879:Salvage Therapy; D016896:Treatment Outcome