title: Perioperative Quality of Life in Cushing's Disease.
abstract: BACKGROUND
  Our study evaluated the perioperative quality of life (QoL) in Cushing's disease (CD) patients, along with correlations between patient variables and cure rate.
  
  
  METHODS
  The 36-item Short-Form Health Survey (SF)-36 questionnaire was used to assess perioperative QoL. Patients completed one survey preoperatively and two surveys postoperatively. Retrospective chart review was conducted to collect SF-36 data as well as examine variables including: age, hospital stay, size of tumour, pathological diagnosis, timing of cure, and complication rates. Statistical analysis was conducted on the scores reported by the SF-36, and were compared with the normal Canadian population values, and to a sample of QoL from nonfunctioning pituitary tumour patients. This project was approved by University of British Columbia Research Ethics Board #H15-01572.
  
  
  RESULTS
  In general, CD patients have relatively poor QoL that does improve as expected when cured, but not quite to normal levels. Factors associated with cure included presence of macroadenoma, confirmatory pathology, and patient age. Postoperative timing of cure appears to affect the durability of cure, with an immediate cure having a higher durability rate than delayed cure. Most recurrences occurred within 10 months postoperatively.
  
  
  CONCLUSIONS
  This review of the perioperative QoL in CD helps to illustrate how QoL changes throughout the treatment process, how QoL compares to normal Canadian population levels, and how QoL compares to patients with nonfunctioning pituitary adenomas. As treatment outcome has such a high impact on QoL, the variables identified in this study will help to better inform patients about the treatment course.
authors.affiliation: 1Faculty of Medicine,University of British Columbia,Vancouver,British Columbia,Canada.
authors.forename: Vincent Chen
authors.initials: VC
authors.lastname: Ye
authors.affiliation: 1Faculty of Medicine,University of British Columbia,Vancouver,British Columbia,Canada.
authors.forename: Ryojo
authors.initials: R
authors.lastname: Akagami
mesh_terms: D000328:Adult; D002170:Canada; D005260:Female; D005500:Follow-Up Studies; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D059035:Perioperative Period / Q000379:methods / Q000523:psychology*; D047748:Pituitary ACTH Hypersecretion / Q000523:psychology* / Q000601:surgery*; D011184:Postoperative Period; D011788:Quality of Life / Q000523:psychology*; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: Neurosurgery; Pituitary Adenomas; Quality of Life