title: Effect of the g.98535683A>G SNP in the CAST gene on meat traits of Nellore beef cattle (Bos indicus) and their crosses with Bos taurus.
abstract: The objective of this study was to estimate allele frequencies of the g.98535683A>G:BTAU7 SNP in the CAST gene in different genetic groups of beef cattle produced in Brazil (Nellore and their crosses with Bos taurus), and to evaluate associations between this polymorphism and meat traits. Five hundred animals from six different genetic groups were genotyped and phenotyped for shear force (SF), myofibrillar fragmentation index (MFI), rib eye area, backfat thickness, and total lipids. Alleles A and G of the SNP were detected in all genetic groups and the frequency of A was higher than G. Significant association (P<0.05) was observed between the polymorphism and meat tenderness (SF and MFI), in which genotype AA exhibited the best values. These results demonstrate for the first time the occurrence of the studied SNP in a Zebu breed and its potential application to the genetic improvement of meat tenderness in the Nellore breed (Bos indicus) and its crosses with Bos taurus.
authors.affiliation: Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, SP 14884-900, Brazil. Electronic address: cruzelenae@gmail.com.
authors.forename: Cruz Elena
authors.initials: CE
authors.lastname: Enriquez-Valencia
authors.affiliation: Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, SP 14884-900, Brazil.
authors.forename: Guilherme Luis
authors.initials: GL
authors.lastname: Pereira
authors.affiliation: Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, SP 14884-900, Brazil.
authors.forename: Jessica Moraes
authors.initials: JM
authors.lastname: Malheiros
authors.affiliation: Departamento de Melhoramento e Nutrição Animal, Faculdade de Medicina Veterinária e Zootecnia, Universidade Estadual Paulista, Botucatu, SP 18618-000, Brazil.
authors.forename: Josineudson Augusto I I
authors.initials: JAII
authors.lastname: de Vasconcelos Silva
authors.affiliation: Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, SP 14884-900, Brazil.
authors.forename: Lúcia Galvão
authors.initials: LG
authors.lastname: Albuquerque
authors.affiliation: Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, SP 14884-900, Brazil.
authors.forename: Henrique Nunes
authors.initials: HN
authors.lastname: de Oliveira
authors.affiliation: Departamento de Melhoramento e Nutrição Animal, Faculdade de Medicina Veterinária e Zootecnia, Universidade Estadual Paulista, Botucatu, SP 18618-000, Brazil.
authors.forename: Luis Artur Loyola
authors.initials: LAL
authors.lastname: Chardulo
authors.affiliation: Departamento de Melhoramento e Nutrição Animal, Faculdade de Medicina Veterinária e Zootecnia, Universidade Estadual Paulista, Botucatu, SP 18618-000, Brazil.
authors.forename: Rogério Abdallah
authors.initials: RA
authors.lastname: Curi
mesh_terms: D000483:Alleles; D000818:Animals; D001938:Brazil; D001947:Breeding; D002135:Calcium-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D002417:Cattle / Q000235:genetics*; D005787:Gene Frequency; D060005:Genotyping Techniques; D016014:Linear Models; D015810:Linkage Disequilibrium; D009210:Myofibrils / Q000378:metabolism; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D000069466:Red Meat / Q000032:analysis*
chemical_list: D002135:Calcium-Binding Proteins; C033668:calpastatin
keywords: Calpastatin; DNA polymorphism; Fat cover; Marbling; Meat tenderness