title: A whole-killed, blood-stage lysate vaccine protects against the malaria liver stage.
abstract: Although the attenuated sporozoite is the most efficient vaccine to prevent infection with the malaria parasite, the limitation of a source of sterile sporozoites greatly hampers its application. In this study, we found that the whole-killed, blood-stage lysate vaccine could confer protection against the blood stage as well as the liver stage. Although the protective immunity induced by the whole-organism vaccine against the blood stage is dependent on parasite-specific CD4+T-cell responses and antibodies, in mice immunized with the whole-killed, blood-stage lysate vaccine, CD8+, but not CD4+effector T-cell responses greatly contributed to protection against the liver stage. Thus, our data suggested that the whole-killed, blood-stage lysate vaccine could be an alternative promising strategy to prevent malaria infection and to reduce the morbidity and mortality of patients with malaria.
authors.affiliation: Department of Pathogenic Biology, Third Military Medical University, Chongqing, China.|Department of Microbiology, Third Military Medical University, Chongqing, China.
authors.forename: X
authors.initials: X
authors.lastname: Lu
authors.affiliation: Department of Pathogenic Biology, Third Military Medical University, Chongqing, China.
authors.forename: T
authors.initials: T
authors.lastname: Liu
authors.affiliation: Department of Pathogenic Biology, Third Military Medical University, Chongqing, China.
authors.forename: F
authors.initials: F
authors.lastname: Zhu
authors.affiliation: Department of Pathogenic Biology, Third Military Medical University, Chongqing, China.
authors.forename: L
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Pathogenic Biology, Third Military Medical University, Chongqing, China.
authors.forename: W
authors.initials: W
authors.lastname: Xu
mesh_terms: D000818:Animals; D005260:Female; D008099:Liver / Q000276:immunology / Q000469:parasitology; D008288:Malaria / Q000276:immunology / Q000517:prevention & control*; D017780:Malaria Vaccines / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010967:Plasmodium yoelii; D034101:Sporozoites / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014611:Vaccination; D015164:Vaccines, Inactivated / Q000276:immunology
chemical_list: D017780:Malaria Vaccines; D015164:Vaccines, Inactivated
keywords: T-cell response; antibody; blood stage; liver stage; whole-killed blood-stage lysate vaccine