title: High-resolution HLA A∼B∼DRB1 haplotype frequencies from the Ezer Mizion Bone Marrow Donor Registry in Israel.
abstract: We have investigated HLA population alleles and haplotype frequencies for the ethnicities that comprise the contemporary population of Israel, using a large data set from the Ezer Mizion Bone Barrow Donor Registry. We genotyped 275,699 individuals at the HLA-A, -B and -DRB1 loci using HLA genotyping methods. HLA A∼B∼DRB1 haplotype frequencies were estimated from 19 sub-ethnic Jewish populations and other non-Jewish minorities using the maximum likelihood model, which accommodates typing ambiguities. We present overall and sub-ethnicity specific HLA diversity results of the registry, which will help guide a data-driven strategy for future registry expansion.
authors.affiliation: Ezer Mizion Bone Marrow Donor Registry, Petach Tikva, Israel. Electronic address: sigal@bmdr.org.il.
authors.forename: Sigal
authors.initials: S
authors.lastname: Manor
authors.affiliation: Bioinformatics Research, National Marrow Donor Program, Minneapolis, MN, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Halagan
authors.affiliation: Ezer Mizion Bone Marrow Donor Registry, Petach Tikva, Israel.
authors.forename: Nira
authors.initials: N
authors.lastname: Shriki
authors.affiliation: Ezer Mizion Bone Marrow Donor Registry, Petach Tikva, Israel; Bone Marrow Transplant Unit, Schneider Children's Medical Center of Israel, Petach Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Isaac
authors.initials: I
authors.lastname: Yaniv
authors.affiliation: Ezer Mizion Bone Marrow Donor Registry, Petach Tikva, Israel.
authors.forename: Bracha
authors.initials: B
authors.lastname: Zisser
authors.affiliation: Bioinformatics Research, National Marrow Donor Program, Minneapolis, MN, USA.
authors.forename: Martin
authors.initials: M
authors.lastname: Maiers
authors.affiliation: Bioinformatics Research, National Marrow Donor Program, Minneapolis, MN, USA.
authors.forename: Abeer
authors.initials: A
authors.lastname: Madbouly
authors.affiliation: Bone Marrow Transplant Unit, Schneider Children's Medical Center of Israel, Petach Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Jerry
authors.initials: J
authors.lastname: Stein
mesh_terms: D016026:Bone Marrow Transplantation; D005006:Ethnicity; D005787:Gene Frequency; D005828:Genetics, Population; D005838:Genotype; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006239:Haplotypes; D059014:High-Throughput Nucleotide Sequencing; D006650:Histocompatibility Testing; D006801:Humans; D007557:Israel; D012042:Registries; D014019:Tissue Donors
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens; D059811:HLA-DRB1 Chains
keywords: Bone marrow donor registry; HLA; Haplotype and allele frequencies; Jewish population