title: Identification and validation of novel drug targets in Mycobacterium tuberculosis.
abstract: Tuberculosis (TB) is a global epidemic associated increasingly with resistance to first- and second-line antitubercular drugs. The magnitude of this global health threat underscores the urgent need to discover new antimycobacterial agents that have novel mechanisms of action (MOA). In this review, we highlight some of the key advances that have enabled the strengths of target-led and phenotypic approaches to TB drug discovery to be harnessed both independently and in combination. Critically, these promise to fuel the front-end of the TB drug pipeline with new, pharmacologically validated drug targets together with lead compounds that act on these targets.
authors.affiliation: MRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research, Institute of Infectious Disease and Molecular Medicine & Department of Pathology, University of Cape Town, Anzio Road, Observatory 7925, South Africa. Electronic address: vinayak.singh@uct.ac.za.
authors.forename: Vinayak
authors.initials: V
authors.lastname: Singh
authors.affiliation: MRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research, Institute of Infectious Disease and Molecular Medicine & Department of Pathology, University of Cape Town, Anzio Road, Observatory 7925, South Africa.
authors.forename: Valerie
authors.initials: V
authors.lastname: Mizrahi
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology*; D055808:Drug Discovery; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D014376:Tuberculosis / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents