title: Delivery of Fluorescent Nanoparticles to the Brain.
abstract: Nanotechnology applications in neuroscience promises to deliver significant scientific and technological breakthroughs, providing answers to unresolved questions regarding the processes occurring in the brain. In this perspective, we provide a short background on two distinct fluorescent nanoparticles and summarize several studies focussed on achieving delivery of these into the brain and their interaction with brain tissue. Furthermore, we discuss challenges and opportunities for further development of nanoparticle-based therapies for targeting delivery of drugs across the blood-brain barrier.
authors.affiliation: School of Mathematical and Physical Sciences, University of Technology Sydney, P.O. Box 123, Broadway, Sydney, NSW, 2007, Australia. olga.shimoni@uts.edu.au.
authors.forename: Olga
authors.identifier: http://orcid.org/0000-0001-8822-1024
authors.initials: O
authors.lastname: Shimoni
authors.affiliation: Department of Biomedical Science, Faculty of Medicine and Health Science, Macquarie University, Sydney, NSW, 2109, Australia.
authors.forename: Bingyang
authors.initials: B
authors.lastname: Shi
authors.affiliation: The Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Adlard
authors.affiliation: The Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia.
authors.forename: Ashley I
authors.initials: AI
authors.lastname: Bush
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000000981:diagnostic imaging / Q000378:metabolism*; D016503:Drug Delivery Systems / Q000379:methods; D005456:Fluorescent Dyes / Q000493:pharmacokinetics*; D006801:Humans; D008164:Luminescent Proteins / Q000493:pharmacokinetics*; D058612:Nanodiamonds; D059906:Neuroimaging / Q000379:methods
chemical_list: D005456:Fluorescent Dyes; D008164:Luminescent Proteins; D058612:Nanodiamonds
keywords: Blood-brain barrier; Fluorescent nanoparticles; Multifunctional nanoparticles; Nanodiamonds; Upconversion nanoparticles