title: Mitochondria in the Aging Muscles of Flies and Mice: New Perspectives for Old Characters.
abstract: Sarcopenia is the loss of muscle mass accompanied by a decrease in muscle strength and resistance and is the main cause of disability among the elderly. Muscle loss begins long before there is any clear physical impact in the senior adult. Despite all this, the molecular mechanisms underlying muscle aging are far from being understood. Recent studies have identified that not only mitochondrial metabolic dysfunction but also mitochondrial dynamics and mitochondrial calcium uptake could be involved in the degeneration of skeletal muscle mass. Mitochondrial homeostasis influences muscle quality which, in turn, could play a triggering role in signaling of systemic aging. Thus, it has become apparent that mitochondrial status in muscle cells could be a driver of whole body physiology and organismal aging. In the present review, we discuss the existing evidence for the mitochondria related mechanisms underlying the appearance of muscle aging and sarcopenia in flies and mice.
authors.affiliation: Centro de Estudios Moleculares de la Célula, ICBM, Facultad de Medicina, Universidad de Chile, 8389100 Santiago, Chile.
authors.forename: Andrea
authors.identifier: 0000-0003-3830-7334
authors.initials: A
authors.lastname: Del Campo
authors.affiliation: Centro de Estudios Moleculares de la Célula, ICBM, Facultad de Medicina, Universidad de Chile, 8389100 Santiago, Chile.
authors.forename: Enrique
authors.identifier: 0000-0002-4938-7176
authors.initials: E
authors.lastname: Jaimovich
authors.affiliation: Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, 8580000 Santiago, Chile.
authors.forename: Maria Florencia
authors.identifier: 0000-0002-8915-1328
authors.initials: MF
authors.lastname: Tevy
mesh_terms: D000375:Aging; D000818:Animals; D002118:Calcium / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D063154:Mitochondrial Dynamics; D063306:Mitophagy; D053580:Muscle Strength; D018482:Muscle, Skeletal / Q000378:metabolism*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species; D002118:Calcium