title: Pulmonary Kirsten Rat Sarcoma Virus Mutation Positive Mucinous Adenocarcinoma Arising in a Congenital Pulmonary Airway Malformation, Mixed Type 1 and 2.
abstract: Congenital pulmonary airway malformation (CPAM) is a developmental abnormality of the lung, which results from an abnormality of branching during fetal development of the lung. We report the case of an 18 year-old woman who developed Kirsten rat sarcoma virus (KRAS) mutation positive mucinous adenocarcinoma of the lung (AC) in association with mixed CPAM type 1 and 2. This case is unique as KRAS mutation positive AC is present in a setting of both CPAM 1 and 2 in the same lesion.
authors.affiliation: Section of Thoracic Surgery, Columbia University Medical Center, New York, New York.
authors.forename: Gopal
authors.initials: G
authors.lastname: Singh
authors.affiliation: Department of Pathology, Columbia University Medical Center, New York, New York.
authors.forename: Amy
authors.initials: A
authors.lastname: Coffey
authors.affiliation: Section of Thoracic Surgery, Columbia University Medical Center, New York, New York.
authors.forename: Robert
authors.initials: R
authors.lastname: Neely
authors.affiliation: Section of Thoracic Surgery, Columbia University Medical Center, New York, New York.
authors.forename: Daniel
authors.initials: D
authors.lastname: Lambert
authors.affiliation: Section of Thoracic Surgery, Columbia University Medical Center, New York, New York.
authors.forename: Joshua
authors.initials: J
authors.lastname: Sonett
authors.affiliation: Department of Pathology, Weill Cornell Medical Center, New York, New York.
authors.forename: Alain C
authors.initials: AC
authors.lastname: Borczuk
authors.affiliation: Section of Thoracic Surgery, Columbia University Medical Center, New York, New York. Electronic address: lag17@columbia.edu.
authors.forename: Lyall
authors.initials: L
authors.lastname: Gorenstein
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology*; D000077192:Adenocarcinoma of Lung; D002288:Adenocarcinoma, Mucinous / Q000473:pathology / Q000601:surgery; D000293:Adolescent; D000818:Animals; D001707:Biopsy, Needle; D002908:Chronic Disease; D015615:Cystic Adenomatoid Malformation of Lung, Congenital / Q000150:complications* / Q000235:genetics / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007708:Kirsten murine sarcoma virus / Q000235:genetics* / Q000302:isolation & purification; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology*; D009154:Mutation / Q000235:genetics; D011013:Pneumonectomy / Q000379:methods; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics*; D051381:Rats; D012141:Respiratory Tract Infections / Q000175:diagnosis / Q000209:etiology; D020775:Thoracic Surgery, Video-Assisted / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome
chemical_list: C528430:Kras protein, rat; D016283:Proto-Oncogene Proteins p21(ras)