title: Lisdexamfetamine dimesylate in binge eating disorder: a placebo controlled trial.
abstract: To evaluate lisdexamfetamine dimesylate (LDX) in the treatment of binge eating disorder (BED).
  
  
  
  Fifty participants with BED received LDX (20-70 mg/day) (n = 25) or placebo (n = 25) for up to 12 weeks in a single-center, randomized, double-blind, and flexible-dose trial. The primary outcome measure was binge eating (BE) days/week.
  
  
  
  In the primary longitudinal analysis, compared with placebo, LDX was not associated with a significantly greater rate of reduction in BE days/week, as well as BE episodes/week, and scores on the Clinical Global Impression-Severity or Yale-Brown Obsessive-Compulsive Scale modified for binge eating scales. It was, however, associated with significantly decreased weight, body mass index, and fasting triglyceride level. In the secondary last observation carried forward analyses, LDX was associated with statistically significant reductions in BE days/week, BE episodes/week, weight, and BMI, as well as a statistically significant greater level of categorical response and global improvement. The mean (standard deviation) LDX daily dose at endpoint evaluation was 59.6 (14.9) mg. One participant discontinued LDX for a serious adverse cardiovascular event, which resolved fully.
  
  
  
  Lisdexamfetamine dimesylate may have clinical utility for BED but further studies of its efficacy, tolerability, and safety in this population are needed. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Lindner Center of HOPE, Mason, Ohio, USA. anna.guerdjikova@lindnercenter.org.|Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. anna.guerdjikova@lindnercenter.org.
authors.forename: Anna I
authors.initials: AI
authors.lastname: Guerdjikova
authors.affiliation: Lindner Center of HOPE, Mason, Ohio, USA.
authors.forename: Nicole
authors.initials: N
authors.lastname: Mori
authors.affiliation: Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Blom
authors.affiliation: Lindner Center of HOPE, Mason, Ohio, USA.|Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
authors.forename: Paul E
authors.initials: PE
authors.lastname: Keck
authors.affiliation: Lindner Center of HOPE, Mason, Ohio, USA.
authors.forename: Stephanie L
authors.initials: SL
authors.lastname: Williams
authors.affiliation: Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Welge
authors.affiliation: Lindner Center of HOPE, Mason, Ohio, USA.|Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
authors.forename: Susan L
authors.initials: SL
authors.lastname: McElroy
mesh_terms: D000328:Adult; D056912:Binge-Eating Disorder / Q000188:drug therapy*; D015992:Body Mass Index; D001835:Body Weight; D000697:Central Nervous System Stimulants / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D000069478:Lisdexamfetamine Dimesylate / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000697:Central Nervous System Stimulants; D000069478:Lisdexamfetamine Dimesylate
keywords: binge eating disorder; dopamine; lisdexamfetamine; norepinephrine