title: Functional versus non-functional intratumor heterogeneity in cancer.
abstract: Next-generation sequencing data from human cancers are often difficult to interpret within the context of tumor evolution. We developed a mathematical model describing the accumulation of mutations under neutral evolutionary dynamics and showed that 323/904 cancers (∼30%) from multiple types were consistent with the neutral model of tumor evolution.
authors.affiliation: Evolution and Cancer Laboratory, Barts Cancer Institute, Queen Mary University of London, London, UK; Department of Cell and Developmental Biology, University College London, London, UK.; Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College, London, UK.
authors.forename: Marc J
authors.initials: MJ
authors.lastname: Williams
authors.affiliation: Centre for Evolution and Cancer, The Institute of Cancer Research , London, UK.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Werner
authors.affiliation: Evolution and Cancer Laboratory, Barts Cancer Institute, Queen Mary University of London , London, UK.
authors.forename: Trevor A
authors.initials: TA
authors.lastname: Graham
authors.affiliation: Centre for Evolution and Cancer, The Institute of Cancer Research , London, UK.
authors.forename: Andrea
authors.initials: A
authors.lastname: Sottoriva
keywords: Cancer genome; intratumor heterogeneity; mathematical model; mutation rate; neutral expansion; site-frequency spectrum