title: Prognostic and clinicopathological value of Gli-1 expression in gastric cancer: A meta-analysis.
abstract: Glioma associated oncogene-1 (Gli-1) is considered as a strong positive activator of downstream target genes of hedgehog signal pathway in mammalians. However, its diagnostic and prognostic value in gastric cancer remains unclear and controversial. Therefore, a quantitative meta-analysis was conducted to determine the clinical value of Gli-1 in gastric cancer patients. Twelve eligible articles with 886 gastric cancer patients were included in this meta-analysis. The relationship between Gli-1 expression in gastric cancer patients and clinicopathological features and 5-year overall survival (OS) was evaluated using pooled odds ratios (ORs) and hazard ratio (HR) with 95% confidence intervals (CIs). The meta-analysis showed that the upregulated Gli-1 was associated with sample type (gastric cancer tissues) (OR 10.31, 95%CI 7.14-14.88; P = 0.000), differentiation type (OR 3.76, 95%CI 2.55-5.53; P = 0.000), depth of invasion (OR 8.17, 95%CI 3.60-18.55; P = 0.000), lymph node metastasis (OR 3.97, 95%CI 2.73-5.78; P = 0.000) and high TNM stage (OR 3.65, 95%CI 1.89-7.04; P = 0.000). Three studies including 316 patients were assessed for the correlation between Gli-1 and 5-year OS, which indicated that positive Gli-1 expression was associated with poor prognosis in gastric cancer patients (HR 2.14, 95%CI 1.35-3.40; P = 0.001). Little publication bias was identified by funnel plots and Egger's tests. The sensitivity analysis indicated that no study substantially influenced pooled OR/HR. Taken together, Gli-1 is a credible indicator for highly aggressive tumor with poor prognosis in gastric cancer patients.
authors.affiliation: Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China.
authors.forename: Li
authors.initials: L
authors.lastname: Lu
authors.affiliation: Department of Radiology, Second Hospital of Tianjin Medical University,Tianjin, China.
authors.forename: Menglin
authors.initials: M
authors.lastname: Wu
authors.affiliation: Department of Radiology, Second Hospital of Tianjin Medical University,Tianjin, China.
authors.forename: Feixiang
authors.initials: F
authors.lastname: Zhao
authors.affiliation: Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Fu
authors.affiliation: Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Radiology, Second Hospital of Tianjin Medical University,Tianjin, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Liu
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D016017:Odds Ratio; D011379:Prognosis; D016016:Proportional Hazards Models; D015398:Signal Transduction; D013274:Stomach Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000401:mortality; D016896:Treatment Outcome; D000071676:Zinc Finger Protein GLI1 / Q000235:genetics / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C400551:GLI1 protein, human; D000071676:Zinc Finger Protein GLI1
keywords: Gli-1; gastric cancer; prognosis