title: Long-Term Oncological Outcomes After Laparoscopic Versus Abdominal Radical Hysterectomy in Stage IA2 to IIA2 Cervical Cancer: A Matched Cohort Study.
abstract: The aim of the study was to investigate the long-term oncological outcomes of laparoscopic radical hysterectomy (LRH) and abdominal radical hysterectomy (ARH) for treatment of stage IA2 to IIA2 cervical cancer.
  
  
  
  We matched stage IA2 to IIA2 cervical cancer patients with known risk factors for recurrence who underwent ARH or LRH.
  
  
  
  After matching, a total of 203 patient pairs (LRH-ARH) were included. The LRH and ARH group had similar 5-year recurrence-free survival (RFS) rates (91.3% vs 90.4%, P = 0.83) and overall survival (OS) rates (93.2% vs 92.1%, P = 0.94). Patients with different tumor size (≤2, 2-4, >4 cm) had similar 5-year OS and RFS. Even in patients with pelvic lymph node metastasis, the 5-year RFS (69.20% vs 69.20%, P = 0.87) and OS (77.4% vs 76.3%, P = 0.83) did not differ statistically between the 2 groups. The LRH and ARH group had similar mean time to recurrence (16.29 vs 22.15 months, P = 0.68) and pattern of recurrence (P = 0.63). Compared with ARH, LRH resulted in significantly shorter operating time, less blood loss, and shorter hospital stay. The intraoperative complications rate was similar between the 2 groups (P = 0.72). The rate of postoperative complications was significantly lower in the LRH group than in the ARH group (P = 0.004).
  
  
  
  Laparoscopic radical hysterectomy was associated with fewer operating time, blood loss, postoperative complication, and earlier recovery. Laparoscopic radical hysterectomy is an oncologically safe alternative to ARH.
authors.affiliation: *Department of Obstetrics and Gynecology, the First Affiliated Hospital, Sun Yat-sen University; †Department of Otorhinolaryngology Head and Neck Surgery, the Third Affiliated Hospital of Southern Medical University; and ‡Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Hong Juan
authors.initials: HJ
authors.lastname: Chu
authors.forename: Chun Liang
authors.initials: CL
authors.lastname: Shang
authors.forename: Xiao
authors.initials: X
authors.lastname: Gong
authors.forename: Tian Yu
authors.initials: TY
authors.lastname: Liu
authors.forename: Yun He
authors.initials: YH
authors.lastname: Zhao
authors.forename: Jia Ming
authors.initials: JM
authors.lastname: Huang
authors.forename: Shu-Zhong
authors.initials: SZ
authors.lastname: Yao
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000401:mortality / Q000601:surgery*; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects / Q000379:methods / Q000706:statistics & numerical data*; D010535:Laparoscopy / Q000009:adverse effects / Q000706:statistics & numerical data; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology* / Q000209:etiology; D002583:Uterine Cervical Neoplasms / Q000401:mortality / Q000601:surgery*