title: Niosomes as Nano-Delivery Systems in the Pharmaceutical Field.
abstract: Nanosystems used in the pharmaceutical field aim to guarantee a controlled release and efficacy boost with dose reduction of the drug. The same active ingredient could be vehiculated in different concentrations in distinct nanosystems. Among these nanostructures, the vesicular ones present a versatile delivery system that could be applied to encapsulate lipophilic, amphiphilic, and hydrophilic compounds. Liposomes are the most well-known vesicular nanosystems; however, there are others, such as niosomes, that are composed of nonionic surfactants that are polymeric or conventional. Niosomes could be prepared using the thin film hydration method, in which the active ingredient is solubilized in organic solvent with the surfactant or in aqueous solution depending on its polarity. In addition, co-surfactants could be used to improve stabilization and vesicle integrity because they occupy regions in the interface where the mainly surfactant could not reach. Vesicular nanosystems could be characterized by different techniques, such as microscopy, dynamic light scattering, nuclear magnetic resonance, and others. These nanostructures could be applied to drugs (administered by different routes) or to gene and cosmetic delivery systems.
authors.affiliation: Federal University of Rio de Janeiro, Institute of Macromolecules, Center of Technology, Ilha do Fundao, Rio de Janeiro, Brazil.
authors.forename: Cristal
authors.initials: C
authors.lastname: Cerqueira-Coutinho
authors.affiliation: Federal University of Rio de Janeiro, Faculty of Pharmacy, Department of Drugs and Medicines, Laboratorio de Desenvolvimento Galenico (LADEG), Ilha do Fundao, Rio de Janeiro, Brazil.
authors.forename: Elisabete P
authors.initials: EP
authors.lastname: Dos Santos
authors.affiliation: Federal University of Rio de Janeiro, Institute of Macromolecules, Center of Technology, Ilha do Fundao, Rio de Janeiro, Brazil.
authors.forename: Claudia Regina E
authors.initials: CR
authors.lastname: Mansur
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D003358:Cosmetics / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation; D018014:Gene Transfer Techniques / Q000295:instrumentation; D015316:Genetic Therapy / Q000295:instrumentation; D057927:Hydrophobic and Hydrophilic Interactions; D008081:Liposomes / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D011108:Polymers / Q000737:chemistry; D012995:Solubility; D012997:Solvents / Q000737:chemistry*; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D003358:Cosmetics; D008081:Liposomes; D004364:Pharmaceutical Preparations; D011108:Polymers; D012997:Solvents; D013501:Surface-Active Agents; D014867:Water