title: Remote Actuation of Magnetic Nanoparticles For Cancer Cell Selective Treatment Through Cytoskeletal Disruption.
abstract: Motion of micron and sub-micron size magnetic particles in alternating magnetic fields can activate mechanosensitive cellular functions or physically destruct cancer cells. However, such effects are usually observed with relatively large magnetic particles (>250 nm) that would be difficult if at all possible to deliver to remote sites in the body to treat disease. Here we show a completely new mechanism of selective toxicity of superparamagnetic nanoparticles (SMNP) of 7 to 8 nm in diameter to cancer cells. These particles are coated by block copolymers, which facilitates their entry into the cells and clustering in the lysosomes, where they are then magneto-mechanically actuated by remotely applied alternating current (AC) magnetic fields of very low frequency (50 Hz). Such fields and treatments are safe for surrounding tissues but produce cytoskeletal disruption and subsequent death of cancer cells while leaving healthy cells intact.
authors.affiliation: Center for Nanotechnology in Drug Delivery, University of North Carolina, Chapel Hill, NC, USA.
authors.forename: Alyssa M
authors.initials: AM
authors.lastname: Master
authors.affiliation: Center for Nanotechnology in Drug Delivery, University of North Carolina, Chapel Hill, NC, USA.|Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Philise N
authors.initials: PN
authors.lastname: Williams
authors.affiliation: Macromolecules and Interfaces Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
authors.forename: Nikorn
authors.initials: N
authors.lastname: Pothayee
authors.affiliation: Macromolecules and Interfaces Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
authors.forename: Nipon
authors.initials: N
authors.lastname: Pothayee
authors.affiliation: Macromolecules and Interfaces Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Center for Nanotechnology in Drug Delivery, University of North Carolina, Chapel Hill, NC, USA.|Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Hemant M
authors.initials: HM
authors.lastname: Vishwasrao
authors.affiliation: Nanocenter, G. R. Derzhavin Tambov State University, Tambov, 392000, Russian Federation.|Laboratory of Chemical Design of Bionanomaterials, Faculty of Chemistry, M. V. Lomonosov Moscow State University, Moscow, 117234, Russian Federation.
authors.forename: Yuri I
authors.initials: YI
authors.lastname: Golovin
authors.affiliation: Macromolecules and Interfaces Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
authors.forename: Judy S
authors.initials: JS
authors.lastname: Riffle
authors.affiliation: Center for Nanotechnology in Drug Delivery, University of North Carolina, Chapel Hill, NC, USA.
authors.forename: Marina
authors.initials: M
authors.lastname: Sokolsky
authors.affiliation: Center for Nanotechnology in Drug Delivery, University of North Carolina, Chapel Hill, NC, USA.
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Kabanov
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival; D003599:Cytoskeleton / Q000378:metabolism / Q000473:pathology*; D004560:Electricity; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008954:Models, Biological; D009369:Neoplasms / Q000473:pathology*
chemical_list: D000180:Acrylic Resins; D058185:Magnetite Nanoparticles; C006903:carbopol 940