title: Increased susceptibility of asymmetrically prominent cortical veins correlates with misery perfusion in patients with occlusion of the middle cerebral artery.
abstract: OBJECTIVE
  To evaluate tissue perfusion and venous susceptibility in ischaemic stroke patients as a means to predict clinical status and early prognosis.
  
  
  METHODS
  A retrospective study of 51 ischaemic stroke patients were enrolled in this study. Susceptibility, perfusion and National Institute of Health stroke scale (NIHSS) were compared between patients with and without asymmetrically prominent cortical veins (APCVs). The correlation between susceptibility, perfusion and NIHSS was performed.
  
  
  RESULTS
  Compared to patients without APCVs, the age of patients with APCVs was statistically older (p = 0.017). Patients with APCVs at discharge showed clinical deterioration in their NIHSS. Mean transit time (MTT), time to peak (TTP) and cerebral blood flow (CBF) in the stroke hemisphere were statistically delayed/decreased in patients with and without APCVs (all p < 0.05). In patients with APCVs, the changes in susceptibility positively correlated with increases in MTT and TTP (p < 0.05). Susceptibility and TTP positively correlated and CBF negatively correlated with NIHSS both at admission and discharge (p < 0.05).
  
  
  CONCLUSIONS
  Patients with APCVs have a tendency of deterioration. The presence of APCVs indicates the tissue has increased oxygen extraction fraction. Increased susceptibility from APCVs positively correlated with the delayed MTT and TTP, which reflects the clinical status at admission and predicts an early prognosis.
  
  
  CONCLUSIONS
  • Patients with and without APCVs have similar misery perfusion. • Patients with APCVs have a tendency of deterioration compared to those without. • The presence of APCVs indicated the tissue has increased oxygen extraction fraction. • Increased susceptibility from APCVs positively correlated with the MTT and TTP. • Increased susceptibility from APCVs reflected the clinical status at admission.
authors.affiliation: Radiology Department, Branch of Shanghai First Hospital No.1878, North Sichuan Road, Shanghai, China, 200081.
authors.forename: Yu
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Neurological Department, Tianjin First Central Hospital, Tianjin, China, 300192.
authors.forename: Zhongying
authors.initials: Z
authors.lastname: Gong
authors.affiliation: Radiology Department, Branch of Shanghai First Hospital No.1878, North Sichuan Road, Shanghai, China, 200081.
authors.forename: Yongming
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Neurosurgery Department, Tianjin First Central Hospital, Tianjin, China, 300192.
authors.forename: Binge
authors.initials: B
authors.lastname: Chang
authors.affiliation: Radiology Department, Tianjin First Central Hospital, Tianjin, China, 300192.
authors.forename: Chao
authors.initials: C
authors.lastname: Chai
authors.affiliation: Radiology Department, Zhengzhou University People's Hospital, Zhengzhou, China, 450003.
authors.forename: Taiyuan
authors.initials: T
authors.lastname: Liu
authors.affiliation: Radiology Department, Zhengzhou University People's Hospital, Zhengzhou, China, 450003.
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Han
authors.affiliation: Radiology Department, Zhengzhou University People's Hospital, Zhengzhou, China, 450003. marian9999@163.com.
authors.forename: Meiyun
authors.initials: M
authors.lastname: Wang
authors.affiliation: Siemens Healthcare, MR collaboration, Northeast Asia, No.7, Wangjing Zhonghuan South Road, Beijing, China, 100102.
authors.forename: Tianyi
authors.initials: T
authors.lastname: Qian
authors.affiliation: Radiology Department, Wayne State University, Detroit, MI, USA.
authors.forename: E Mark
authors.initials: EM
authors.lastname: Haacke
authors.affiliation: Radiology Department, Tianjin First Central Hospital, Tianjin, China, 300192. xiashuang77@163.com.
authors.forename: Shuang
authors.initials: S
authors.lastname: Xia
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002550:Cerebral Veins / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D000072226:Computed Tomography Angiography; D018450:Disease Progression; D005260:Female; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000503:physiopathology*; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000502:physiology; D064847:Multimodal Imaging; D010100:Oxygen / Q000502:physiology; D011379:Prognosis; D012189:Retrospective Studies; D020521:Stroke / Q000503:physiopathology*
chemical_list: D010100:Oxygen
keywords: Acute occlusion; Asymmetrically prominent cortical veins; Middle cerebral artery; Misery perfusion; Susceptibility weighted imaging and mapping