title: Clinical Evaluation of 2 Point-of-Care Lateral Flow Tests for the Diagnosis of Syphilis.
abstract: A diagnostic performance study comparing the only Food and Drug Administration-approved, point-of-care (POC) treponemal test (Syphilis Health Check) and the World Health Organization pre-qualified SD Bioline POC treponemal test against a treponemal hemagglutination test (TPHA) and a sequential algorithm of nontreponemal rapid plasma reagin and TPHA found both POC tests had >85% sensitivity compared with the TPHA and >85% sensitivity and >95% specificity compared with the rapid plasma reagin and TPHA standards.
authors.affiliation: From the *STD Clinic/Ward 12, Mulago National Tertiary Referral Hospital; †School of Public Health, Makerere University College of Health Sciences; ‡Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda; and §Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore MD.
authors.forename: Edith
authors.initials: E
authors.lastname: Nakku-Joloba
authors.forename: Agnes
authors.initials: A
authors.lastname: Kiragga
authors.forename: Joshua Kimeze
authors.initials: JK
authors.lastname: Mbazira
authors.forename: Fred
authors.initials: F
authors.lastname: Kambugu
authors.forename: Mary
authors.initials: M
authors.lastname: Jett-Goheen
authors.forename: Rosalind Parkes
authors.initials: RP
authors.lastname: Ratanshi
authors.forename: Charlotte
authors.initials: C
authors.lastname: Gaydos
authors.forename: Yukari C
authors.initials: YC
authors.lastname: Manabe
mesh_terms: D000328:Adult; D000465:Algorithms; D000907:Antibodies, Bacterial / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006386:Hemagglutination Tests; D006801:Humans; D008297:Male; D019095:Point-of-Care Systems; D011935:Reagins / Q000097:blood; D012680:Sensitivity and Specificity; D013587:Syphilis / Q000175:diagnosis* / Q000382:microbiology; D013588:Syphilis Serodiagnosis; D014210:Treponema pallidum / Q000276:immunology* / Q000302:isolation & purification; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D011935:Reagins