title: NBR2: A former junk gene emerges as a key player in tumor suppression.
abstract: NBR2 (neighbor of BRCA1 gene 2) is a non-protein coding gene that resides adjacent to tumor suppressor gene BRCA1, but its role in cancer biology has remained unknown. Our recent study showed that NBR2 encodes a long non-coding RNA and suppresses tumor development through regulation of adenosine monophosphate-activated protein kinase (AMPK) activation.
authors.affiliation: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center , Houston, TX, USA.
authors.forename: Zhen-Dong
authors.initials: ZD
authors.lastname: Xiao
authors.affiliation: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center , Houston, TX, USA.
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center , Houston, TX, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Zhuang
authors.affiliation: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center , Houston, TX, USA.
authors.forename: Boyi
authors.initials: B
authors.lastname: Gan
keywords: AMPK; BRCA1; NBR2; energy stress response; lncRNA; tumor suppression