title: Antiobesity Effect of Garlic Extract Fermented by Lactobacillus plantarum BL2 in Diet-Induced Obese Mice.
abstract: Obesity is viewed as a serious public health problem. This study aimed to investigate the antiobesity effects of fermented garlic extract by lactic acid bacteria (LAFGE) on obesity. Male C57BL/6J mice were fed with high-fat diet (HFD) to induce obesity. The HFD-induced obese mice were orally administrated with 250 or 500 mg/kg LAFGE for 8 weeks. Feeding HFD-fed mice with 250 or 500 mg/kg LAFGE reduced body weight by 14% and 18%, respectively, compared to HFD. HFD-fed mice with 500 mg/kg LAFGE administration had lower epididymal, retroperitoneal, and mesenteric adipose tissue mass by 36%, 44%, and 63%, respectively, compared to HFD. The concentration of plasma triacylglyceride and total cholesterol was significantly lower in the HFD-fed mice with LAFGE administration. Moreover, LAFGE supplementation suppressed adipogenesis by downregulation in mRNA and protein expression of PPARγ, C/EBPα, and lipogenic proteins, including SREBP-1c, FAS, and SCD-1. Based on these findings, LAFGE may ameliorate diet-induced obesity by inhibiting adipose tissue hypertrophy by suppressing adipogenesis.
authors.affiliation: 1 Department of Food and Biotechnology, Korea University , Sejong City, Republic of Korea.
authors.forename: Hee-Seop
authors.initials: HS
authors.lastname: Lee
authors.affiliation: 1 Department of Food and Biotechnology, Korea University , Sejong City, Republic of Korea.
authors.forename: Won-Chul
authors.initials: WC
authors.lastname: Lim
authors.affiliation: 2 R&D Center , Bioland, Gyeonggi, Republic of Korea.
authors.forename: Sung-Jin
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: 2 R&D Center , Bioland, Gyeonggi, Republic of Korea.
authors.forename: Seung-Hyun
authors.initials: SH
authors.lastname: Lee
authors.affiliation: 1 Department of Food and Biotechnology, Korea University , Sejong City, Republic of Korea.
authors.forename: Jin-Hyup
authors.initials: JH
authors.lastname: Lee
authors.affiliation: 1 Department of Food and Biotechnology, Korea University , Sejong City, Republic of Korea.
authors.forename: Hong-Yon
authors.initials: HY
authors.lastname: Cho
mesh_terms: D050156:Adipogenesis / Q000187:drug effects*; D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001835:Body Weight / Q000187:drug effects; D022763:CCAAT-Enhancer-Binding Protein-alpha / Q000097:blood; D002784:Cholesterol / Q000097:blood; D059305:Diet, High-Fat; D015536:Down-Regulation; D005285:Fermentation; D005737:Garlic; D048191:Lactiplantibacillus plantarum / Q000378:metabolism*; D050356:Lipid Metabolism / Q000187:drug effects; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity / Q000188:drug therapy / Q000378:metabolism*; D047495:PPAR gamma / Q000097:blood; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D012333:RNA, Messenger / Q000378:metabolism; D013230:Stearoyl-CoA Desaturase / Q000097:blood; D051780:Sterol Regulatory Element Binding Protein 1 / Q000097:blood; D014280:Triglycerides / Q000097:blood
chemical_list: D019440:Anti-Obesity Agents; D022763:CCAAT-Enhancer-Binding Protein-alpha; D047495:PPAR gamma; D010936:Plant Extracts; D012333:RNA, Messenger; D051780:Sterol Regulatory Element Binding Protein 1; D014280:Triglycerides; D002784:Cholesterol; D013230:Stearoyl-CoA Desaturase; C000594769:stearoyl-CoA desaturase SCD-1, rat
keywords: Lactobacillus (Acidophilus, Bulgaricus,and others); antiobesity; fermented foods; garlic