title: Structural modulation of the gut microbiota and the relationship with body weight: compared evaluation of liraglutide and saxagliptin treatment.
abstract: The mechanisms underlying the weight-loss effect of GLP-1 receptor agonists need further elucidation. The present study was performed to explore the effects of liraglutide and saxagliptin on the composition of the gut microbiota. Mice were randomly treated with saxagliptin or liraglutide for eight weeks. Their metabolic profiles were assessed, and 454 pyrosequencing of 16s rRNA of faeces was performed. Liraglutide induced a smaller body weight gain in mice. The pyrosequencing showed that liraglutide, but not saxagliptin, substantially changed the overall structure of the gut microbiota as well as the relative abundance of weight-relevant phylotypes. Subsequent ridge regression analyses indicated that, in addition to food intake (β = -0.182, p = 0.043 in phylotypes inversely correlated with body weight) and blood glucose level (β = -0.240, p = 0.039 in phylotypes positively correlated with body weight), the administration of liraglutide was another independent factor associated with the abundance of weight-relevant phylotypes (β = 0.389, p = 6.24e-5 in inversely correlated ones; β = -0.508, p = 2.25e-5 in positively correlated ones). These results evidenced that GLP-1 receptor agonist liraglutide could modulate the composition of the gut microbiota, leading to a more lean-related profile that was consistent with its weight-losing effect.
authors.affiliation: Department of Metabolism and Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, People's Republic of China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Metabolism and Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, People's Republic of China.
authors.forename: Peicheng
authors.initials: P
authors.lastname: Li
authors.affiliation: Department of Metabolism and Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, People's Republic of China.
authors.forename: Zhaosheng
authors.initials: Z
authors.lastname: Tang
authors.affiliation: Department of Metabolism and Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, People's Republic of China.
authors.forename: Xinfeng
authors.initials: X
authors.lastname: Yan
authors.affiliation: Department of Metabolism and Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, People's Republic of China.
authors.forename: Bo
authors.initials: B
authors.lastname: Feng
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects*; D004269:DNA, Bacterial / Q000235:genetics; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D004151:Dipeptides / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects; D005243:Feces / Q000382:microbiology; D000069196:Gastrointestinal Microbiome / Q000187:drug effects / Q000235:genetics; D015870:Gene Expression; D000067757:Glucagon-Like Peptide-1 Receptor / Q000235:genetics / Q000378:metabolism; D006943:Hyperglycemia / Q000139:chemically induced / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D000069450:Liraglutide / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D013311:Streptozocin; D000097789:Glucagon-Like Peptide-1 Receptor Agonists
chemical_list: D001786:Blood Glucose; D004269:DNA, Bacterial; D004151:Dipeptides; C000593834:Glp1r protein, mouse; D000067757:Glucagon-Like Peptide-1 Receptor; D007004:Hypoglycemic Agents; D012336:RNA, Ribosomal, 16S; D013311:Streptozocin; D000069450:Liraglutide; C502994:saxagliptin; D000218:Adamantane; D000097789:Glucagon-Like Peptide-1 Receptor Agonists