title: Bisphosphonate related osteonecrosis of the jaws (BRONJ) in osteoporotic males.
abstract: BACKGROUND
  The purpose of this study was to describe the clinical characteristics of bisphosphonate related osteonecrosis of the jaws (BRONJ) in osteoporotic males.
  
  
  METHODS
  The medical records of BRONJ patients from 2007 to 2014 were reviewed. The data from only the male patients was extracted, and demographic data was collected and biochemical markers were measured.
  
  
  RESULTS
  11 Patients out of 210 (5 %) being males. Among the 11 patients, the indication of bisphosphonate (BP) was osteoporosis in 9 patients, and cancer in two. In one of the osteoporosis patients, osteoporosis was thought to be secondary to hypogonadism after testicular tumor resection. Serum c-terminal telopetide crosslink of type I collagen (s-CTX) values ranged from 60 to 165 pg/mL (mean: 84.6 ± 36.8, median: 70). Serum osteocalcin (s-OC) ranged from 0 to 5.06 ng/mL (mean: 1.83 ± 1.66, median: 1.5) and vitamin D ranged from 0 to 11.9 (mean: 5.02 ± 4.92, median: 3.5).
  
  
  CONCLUSIONS
  BRONJ can be overlooked in male patients with osteoporosis. Although the incidence of BRONJ in males may be low, dentists should also check if their male patients are on osteoporosis treatment since osteoporosis in males can be manifested as a secondary disease to hypogonadism.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Graduate School, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Yong-Dae
authors.initials: YD
authors.lastname: Kwon
authors.affiliation: Department of Oral and Maxillofacial Surgery, Graduate School, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Chae-Yoon
authors.initials: CY
authors.lastname: Lee
authors.affiliation: Department of Oral and Maxillofacial Surgery, Graduate School, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Sung Ok
authors.initials: SO
authors.lastname: Hong
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Republic of Korea.
authors.forename: Yeon-Ah
authors.initials: YA
authors.lastname: Lee
authors.affiliation: Department of Oral and Maxillofacial Surgery, Graduate School, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Joo-Young
authors.initials: JY
authors.lastname: Ohe
authors.affiliation: Department of Nuclear Medicine, Kyung Hee University School of Medicine, Seoul, 02447 Republic of Korea.
authors.forename: Deog-Yoon
authors.initials: DY
authors.lastname: Kim
keywords: BRONJ; Bisphosphonate related osteonecrosis; ONJ