title: Use of intravoxel incoherent motion diffusion-weighted imaging in identifying the vascular and avascular zones of human meniscus.
abstract: To investigate the hypothesis that the intravoxel incoherent motion (IVIM) diffusion-weighted imaging may depict microcirculation of meniscus and the perfusion changes in meniscal disorder.
  
  
  
  Fifty patients received diffusion-weighted MRI with multiple b-values ranging from 0 to 400 s/mm2. The four horns of the menisci were divided into normal, degenerated, and torn groups. IVIM parameters including perfusion fraction (f), pseudo-diffusion coefficient (D*), true diffusion coefficient (D), and the product of f and D* (f D*) of normal meniscal red zone and white zone were derived and compared for microcirculation changes of normal, degenerated, and torn posterior horn of the medial meniscus (PMM). The parameters between red and white zones among the groups were compared. Significant differences were considered when P < 0.05.
  
  
  
  Mean f and fD* were significantly higher in the red zone than those in the white zone for the normal four meniscal horns (P < 0.05), whereas D* (P = 0.882, 0.011, 0.593, and 0.33) and D (P = 0.186, 0.099, 0.767, and 0.041) did not significantly differ between the two zones. Among the normal, degenerated, and torn PMM, f was observed to be lower in the red zone of torn horns as compared to the normal horns (P = 0.013). D*, fD*, and D did not exhibit statistically significant difference among different groups (P = 0.353, 0.661, and 0.327, respectively).
  
  
  
  This hypothesis driven work shows that IVIM imaging is able to depict microcirculation of meniscus and the perfusion changes in meniscal disorder.
  
  
  
  3 J. Magn. Reson. Imaging 2017;45:1090-1096.
authors.affiliation: Department of Radiology, Beijing Hospital, Beijing, China.
authors.forename: Tan
authors.initials: T
authors.lastname: Guo
authors.affiliation: Department of Radiology, Beijing Hospital, Beijing, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Chen
authors.affiliation: GE Healthcare China, Beijing, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Wu
authors.affiliation: GE Healthcare China, Beijing, China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Zheng
authors.affiliation: Department of Radiology, Beijing Hospital, Beijing, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Jiao
authors.affiliation: Department of Radiology, Beijing Hospital, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Song
authors.affiliation: Department of Radiology, Beijing Hospital, Beijing, China.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D000072600:Meniscus / Q000098:blood supply* / Q000000981:diagnostic imaging*; D008875:Middle Aged; D009038:Motion; D055815:Young Adult
keywords: DWI; intravoxel incoherent motion imaging; meniscal tear; meniscus; red zone; white zone