title: Noninvasive follicular thyroid neoplasm with papillary-like nuclear features.
abstract: Recently, it was proposed that some papillary thyroid carcinomas (PTC) will no longer be termed 'cancer' and are christened as 'noninvasive follicular thyroid neoplasm with papillary-like nuclear features' (NIFTP). As this is a recent definition, little information is available about NIFTP. The objective of this study was to report the frequency, ultrasonographic appearance, cytology result and long-term evolution of cases of NIFTP seen at our institution. We excluded tumours ≤1 cm. The sample consisted of 129 patients. Sixty-four patients were submitted to total thyroidectomy and 65 to lobectomy. These patients with NIFTP did not receive radioiodine. NIFTP corresponded to 15% of cases diagnosed as PTC >1 cm. An ultrasonographic appearance considered to be of low suspicion for malignancy was common in NIFTP (32.5%), whereas a highly suspicious appearance was uncommon (5%). NIFTP frequently exhibited indeterminate cytology (62%), while malignant cytology was uncommon (4%). The patients were followed up for 12-146 months (median 72 months) after surgery. None of the patients developed structural disease during follow-up. Comparing the concentrations of thyroglobulin (Tg) and anti-Tg antibodies (TgAb) obtained 6-12 months after surgery and in the last assessment, none of the patients exhibited an increase in these markers.
authors.affiliation: Santa Casa de Belo HorizonteMinas Gerais, Brazil pedrowsrosario@gmail.com.
authors.forename: Pedro Weslley
authors.initials: PW
authors.lastname: Rosario
authors.affiliation: Santa Casa de Belo HorizonteMinas Gerais, Brazil.
authors.forename: Gabriela Franco
authors.initials: GF
authors.lastname: Mourão
authors.affiliation: Santa Casa de Belo HorizonteMinas Gerais, Brazil.
authors.forename: Maurício Buzelin
authors.initials: MB
authors.lastname: Nunes
authors.affiliation: Santa Casa de Belo HorizonteMinas Gerais, Brazil.
authors.forename: Marcelo Saldanha
authors.initials: MS
authors.lastname: Nunes
authors.affiliation: Santa Casa de Belo HorizonteMinas Gerais, Brazil.
authors.forename: Maria Regina
authors.initials: MR
authors.lastname: Calsolari
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000368:Aged; D044963:Biopsy, Fine-Needle; D002291:Carcinoma, Papillary / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D018193:Neoplasms, Complex and Mixed / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D013965:Thyroidectomy; D047368:Tumor Burden; D014463:Ultrasonography; D055815:Young Adult
keywords: NIFTP; cytology; long-term; noninvasive encapsulated follicular variant; ultrasonography