title: Roles of LPA receptor signaling in breast cancer.
abstract: LPA and its receptors play an important role in mediating malignant behaviors in various cancers, including breast cancer. Aberrant expression of certain LPA receptors in breast cancer suggested that LPA receptors could be potential biomarkers in understanding malignant growth patterns of breast cancer. Further research considering molecular mechanisms for LPA receptors will contribute to new methods of malignant breast cancer diagnosis and treatment. Areas covered: Accumulating studies have indicated that LPA receptors correlated to proliferation, invasion, migration and metastasis both in vivo and in vitro. In this manuscript, we have reviewed LPA receptors expressions and LPA mediated biological behaviors in cell lines, mouse models and patients and their potential molecular pathways. Expert commentary: LPA receptors could be applied in early diagnosis, survival rate prediction, metastasis probability and potential treatment targets. However, further studies are required to clarify the upstream and downstream molecular mechanisms of LPA receptors in breast cancer.
authors.affiliation: a The Second Department of Thoracic Surgery , The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , P.R. China.
authors.forename: Jizhao
authors.initials: J
authors.lastname: Wang
authors.affiliation: b Department of Radiation Oncology , The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , P.R. China.
authors.forename: Yuchen
authors.initials: Y
authors.lastname: Sun
authors.affiliation: a The Second Department of Thoracic Surgery , The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , P.R. China.
authors.forename: Jingkun
authors.initials: J
authors.lastname: Qu
authors.affiliation: a The Second Department of Thoracic Surgery , The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , P.R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yan
authors.affiliation: c Department iii of Radiation Oncology, 2 Comprehensive Thermal Therapy Center , The First Affiliated Hospital of Zhengzhou University , Zhengzhou , P.R. China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Yang
authors.affiliation: d The Department of Vascular Surgery , The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , P.R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Cai
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D015415:Biomarkers; D001943:Breast Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D002465:Cell Movement; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D018450:Disease Progression; D019008:Drug Resistance, Neoplasm; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008246:Lysophospholipids / Q000096:biosynthesis; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D049368:Receptors, Lysophosphatidic Acid / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D059467:Transcriptome; D000099189:Lysophospholipase D
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; D008246:Lysophospholipids; D010727:Phosphoric Diester Hydrolases; D049368:Receptors, Lysophosphatidic Acid; D000099189:Lysophospholipase D
keywords: LPA receptors; biomarker; breast cancer; clinical implication; expression; malignant behaviors