title: Prevalence and risk factors of chorioamnionitis in Dhaka, Bangladesh.
abstract: To estimate the association between chorioamnionitis, maternal risk factors and birth outcomes.
  
  
  
  A cross-sectional study of 600 pregnant women was conducted at a maternity center in Dhaka from January to October 2011. Outcomes included histologic, microbiologic and clinical chorioamnionitis. Log-binomial models assessed the association between risk factors and histologic chorioamnionitis (HC).
  
  
  
  Of the 552 women with placental specimens, 70 (12.7%) were classified with HC: 46 (65.7%) with and 24 (34.3%) without fetal involvement. HC was associated with non-physician care (relative risk [RR] 2.04, 95% confidence interval [CI] 1.04 to 4.00), home slab or hanging latrine (RR 1.69, 95% CI 1.10 to 2.62), and lack of tetanus toxoid (RR 1.80, 95% CI 1.03 to 3.14). Women with fever (RR 2.30, 95% CI 1.18 to 4.50) or discolored amniotic fluid (RR 1.74, 95% CI 1.08 to 2.81) had a higher risk of HC. Microbiologic and clinical chorioamnionitis were unreliable HC measures.
  
  
  
  Prevalence of HC is high; many cases are not captured by clinical diagnosis or microbiologic cultures.
authors.affiliation: Division of Medicine Critical Care, Boston Children's Hospital, Boston, MA, USA.|Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
authors.forename: G J
authors.initials: GJ
authors.lastname: Chan
authors.affiliation: Division of Medicine Critical Care, Boston Children's Hospital, Boston, MA, USA.
authors.forename: M
authors.initials: M
authors.lastname: Silverman
authors.affiliation: Centre for Child and Adolescent Health, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
authors.forename: M
authors.initials: M
authors.lastname: Zaman
authors.affiliation: Department of Pathology, Boston Children's Hospital, Boston, MA, USA.
authors.forename: A
authors.initials: A
authors.lastname: Murillo-Chaves
authors.affiliation: Centre for Child and Adolescent Health, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
authors.forename: A
authors.initials: A
authors.lastname: Mahmud
authors.affiliation: Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
authors.forename: A H
authors.initials: AH
authors.lastname: Baqui
authors.affiliation: Department of Pathology, Boston Children's Hospital, Boston, MA, USA.
authors.forename: T K
authors.initials: TK
authors.lastname: Boyd
mesh_terms: D000293:Adolescent; D000328:Adult; D000653:Amniotic Fluid / Q000382:microbiology; D001459:Bangladesh / Q000453:epidemiology; D002821:Chorioamnionitis / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D010920:Placenta / Q000382:microbiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D015995:Prevalence; D012307:Risk Factors; D055815:Young Adult