title: [RELATIONSHIP BETWEEN INFLAMMATIONAND HEART DYSSYNCHRONY IN PATIENTS WITH CHRONIC HEART FAILURE AND DIABETES MELLITUS TYPE 2].
abstract: The study involved 100 patients with chronic heart failure of ischemic origin II-III functional class (NYNA) and diabetes mellitus type 2. The concentration of serum markers of inflammation was determined by enzyme immunoassay. Сardiac dyssynchrony was detected echocardiographic and electrocardiographic methods. The study showed that the presence of cardiac dyssynchrony is accompanied by significant increase concentrations of inflammatory markers (CRP (p=2•10-9), TNF-α (p=4•10-6), IL-1β (p=0,01596), IL-6 (р=2•10-6) in patients. Аlso revealed statistically significant direct correlations between levels: Ts and CRP (r=0,604; p<0,001) and Ts-SD (r=0,611; p<0,001); TNF-α and Ts (r=0,585; p<0,001) and Ts-SD (r=0,561; p<0,001); IL-1β with the QRS (r=0,257; p<0,05), Ts (r=0,365; p<0,001), Ts-SD (r=0,350; p<0,001) and IVMD (r=0,272; p<0,05); IL-6 and Ts (r=0,744, p<0,001) and Ts-SD (r=0,744; p<0,001), which implies that the amplification of inflammation contributes to the further progression of myocardial dyssynchrony in patients with chronic heart failure of ischemic origin and type 2 diabetes.
authors.affiliation: Kharkiv Medical Academy of Postgraduate Education, Kharkov, Ukraine.
authors.forename: I
authors.initials: I
authors.lastname: Asoyan
authors.affiliation: Kharkiv Medical Academy of Postgraduate Education, Kharkov, Ukraine.
authors.forename: A
authors.initials: A
authors.lastname: Bilchenko
authors.affiliation: Kharkiv Medical Academy of Postgraduate Education, Kharkov, Ukraine.
authors.forename: S
authors.initials: S
authors.lastname: Pavlov
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D002908:Chronic Disease; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging / Q000503:physiopathology; D006333:Heart Failure / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000150:complications / Q000503:physiopathology; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D017202:Myocardial Ischemia / Q000097:blood / Q000150:complications / Q000503:physiopathology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D053583:Interleukin-1beta; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein