title: Phenylboronic Acid-Cross-Linked Nanoparticles with Improved Stability as Dual Acid-Responsive Drug Carriers.
abstract: Herein, a kind of dual acid-sensitive nanoparticles based on monomethoxy poly(ethylene glycol)-imine-β-cyclodextrin is constructed by a facile phenylboronic acid-cross-linked way. The data of dynamic light scattering and transmission electron microscope reveal the cross-linked nanoparticles have improved stability. The cross-linked nanoparticles could easily self-assemble and load the anticancer drug at neutral pH condition. However, when the drug-loaded nanoparticles are delivered to extracellular tumor sites (pH ≈6.8), the surface of the nanoparticles would be amino positively charged and easily internalized by tumor cell due to the cleavage of the acid-labile benzoic-imine. Subsequently, with the acidity in subcellular compartments significantly increasing (such as the endosome pH ≈5.3), the loaded drug would fast release from the endocytosis carriers due to the hydrolysis of boronate ester. These features suggest that these dual acid-sensitive cross-linked nanoparticles not only possess excellent biocompatibility but also can efficiently load and deliver anticancer drug into tumor cells to enhance the inhibition of cellular proliferation, outlining a favorable platform as drug carriers.
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China.
authors.forename: Chunran
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China.
authors.forename: Jinze
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Chen
authors.affiliation: Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.
authors.forename: Xu
authors.initials: X
authors.lastname: Zheng
authors.affiliation: Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Xie
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.affiliation: Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.
authors.forename: Xuesi
authors.initials: X
authors.lastname: Chen
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000138:chemical synthesis; D001897:Boronic Acids / Q000008:administration & dosage / Q000737:chemistry; D004317:Doxorubicin / Q000008:administration & dosage / Q000138:chemical synthesis; D004337:Drug Carriers / Q000008:administration & dosage / Q000138:chemical synthesis*; D016503:Drug Delivery Systems; D056945:Hep G2 Cells; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011092:Polyethylene Glycols
chemical_list: D000970:Antineoplastic Agents; D001897:Boronic Acids; D004337:Drug Carriers; D011092:Polyethylene Glycols; D004317:Doxorubicin; C010686:benzeneboronic acid
keywords: anticancer; cross-linked micelles; drug delivery; dual pH-responsive; phenylboronic acid