title: Increased prenatal blood manganese may induce gestational blood pressure.
abstract: OBJECTIVE
  Pregnancy hypertension is the most common gestational complication and poses a critical risk for mother and fetus. Whether environmental factors may play an important role in disease occurrence is not fully determined.
  
  
  METHODS
  To investigate the effects of prenatal manganese (Mn) exposure on gestational blood pressure, 386 women were examined.
  
  
  RESULTS
  Early pregnancy blood Mn was significantly (p < 0.05) correlated with blood pressure through gestation. A significant association between odds of pre-hypertension with blood Mn was shown (OR:1.150, 95% CI:1.052-1.258).
  
  
  CONCLUSIONS
  The current study results might suggest the blood Mn level during early stage of pregnancy as a potential risk factor for increasing the risk of gestational blood pressure.
authors.affiliation: a Department of Occupational Epidemiology , National Institute of Occupational Safety and Health , Kawasaki , Japan.|b Department of Epidemiology and Environmental Health , Juntendo University Faculty of Medicine , Tokyo , Japan.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Vigeh
authors.affiliation: b Department of Epidemiology and Environmental Health , Juntendo University Faculty of Medicine , Tokyo , Japan.
authors.forename: Emiko
authors.initials: E
authors.lastname: Nishioka
authors.affiliation: b Department of Epidemiology and Environmental Health , Juntendo University Faculty of Medicine , Tokyo , Japan.
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Yokoyama
authors.affiliation: a Department of Occupational Epidemiology , National Institute of Occupational Safety and Health , Kawasaki , Japan.
authors.forename: Katsumi
authors.initials: K
authors.lastname: Ohtani
authors.affiliation: b Department of Epidemiology and Environmental Health , Juntendo University Faculty of Medicine , Tokyo , Japan.
authors.forename: Takehisa
authors.initials: T
authors.lastname: Matsukawa
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D016640:Diabetes, Gestational / Q000097:blood / Q000209:etiology*; D005260:Female; D006801:Humans; D008345:Manganese / Q000097:blood / Q000633:toxicity*; D018811:Maternal Exposure / Q000009:adverse effects*; D011247:Pregnancy
chemical_list: D008345:Manganese
keywords: Manganese; blood pressure; pre-hypertension; pregnancy; prenatal