title: SERKing Coreceptors for Receptors.
abstract: Plants have evolved a large number of cell surface-resident receptor-like kinases (RLKs) and receptor-like proteins (RLPs), many of which are implicated in sensing extrinsic and intrinsic signals, and govern diverse cellular responses. The signaling pathways mediated by RLKs and RLPs converge at a small group of RLKs, somatic embryogenesis receptor kinases (SERKs), via ligand-induced heterodimerization and transphosphorylation. As shared coreceptors in diverse signaling receptorsomes, SERKs exhibit functional plasticity yet maintain a high degree of signaling specificity. Here, we review recent advances in newly identified SERK functions in plant cell differentiation, growth, and immunity; discuss the regulation and activation mechanisms of SERK-associated receptorsomes; and provide insights into how SERKs maintain signaling specificity as convergent hubs in various signaling pathways.
authors.affiliation: Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX 77843, USA; Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX 77843, USA.
authors.forename: Xiyu
authors.initials: X
authors.lastname: Ma
authors.affiliation: Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX 77843, USA; Molecular & Environmental Plant Sciences, Texas A&M University, College Station, TX 77843, USA.
authors.forename: Guangyuan
authors.initials: G
authors.lastname: Xu
authors.affiliation: Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX 77843, USA; Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX 77843, USA; Molecular & Environmental Plant Sciences, Texas A&M University, College Station, TX 77843, USA.
authors.forename: Ping
authors.initials: P
authors.lastname: He
authors.affiliation: Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX 77843, USA; Molecular & Environmental Plant Sciences, Texas A&M University, College Station, TX 77843, USA; Department of Plant Pathology & Microbiology, Texas A&M University, College Station, TX 77843, USA. Electronic address: lshan@tamu.edu.
authors.forename: Libo
authors.initials: L
authors.lastname: Shan
mesh_terms: D018506:Gene Expression Regulation, Plant; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism*; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*
chemical_list: D010940:Plant Proteins; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases
keywords: plant growth and development; plant immunity; receptor-like kinases (RLKs); receptor-like proteins (RLPs); somatic embryogenesis receptor kinases (SERKs)