title: Standardization procedure for the nasal nitric oxide measurement method using Niox MINO® and the tidal-breathing technique with velum-closure.
abstract: Nitric oxide (NO) is a molecule that performs many functions in the human body. The entire respiratory tract can produce NO, but the highest production occurs in the upper respiratory tract, in the paranasal sinuses in particular. The aim of the present study was to assess a new nasal NO (nNO) measurement method using the Niox MINO Nasal® device (Aerocrine AB, Solna, Sweden) and a special procedure, in order to compare the nNO values obtained in 32 healthy subjects with the values found in the international literature. The measured normal nNO values were equal to 426.76±143.27 ppb, with a 95% confidence interval [160.22-733.30]. Males had an average nNO value equal to 446.76±133.63 [178.64  714.02], whereas in females the average value was 403.80±154.90 [94.00-713.60]. This study allows us to confirm that we have been able to establish the normal range of nitric oxide quantity produced in the nasal/sinus cavities of healthy individuals using the Niox MINO Nasal® device and tidal-breathing with velum-closure manoeuvre.
authors.affiliation: Section of Otolaryngology, Department of Basic Medical Science, Neuroscience and Sensory Organs, University of Bari, Bari, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Gelardi
authors.affiliation: Section of Otolaryngology, Department of Basic Medical Science, Neuroscience and Sensory Organs, University of Bari, Bari, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Abbattista
authors.affiliation: Section of Otolaryngology, Department of Basic Medical Science, Neuroscience and Sensory Organs, University of Bari, Bari, Italy.
authors.forename: V N
authors.initials: VN
authors.lastname: Quaranta
authors.affiliation: Section of Otolaryngology, Department of Basic Medical Science, Neuroscience and Sensory Organs, University of Bari, Bari, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Quaranta
authors.affiliation: Otorhinolaryngology Unit, Department of Neuroscienze, A.O.U. Pisana, Pisa, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Seccia
authors.affiliation: Medical and Scientific Department, Stallergenes, Milan, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Buttafava
authors.affiliation: Medical and Scientific Department, Stallergenes, Milan, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Frati
authors.affiliation: Department of Internal Medicine, IRCCS A.O.U. San Martino, Genoa, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Ciprandi
mesh_terms: D000328:Adult; D001944:Breath Tests / Q000295:instrumentation / Q000379:methods*; D055664:Electrochemical Techniques / Q000295:instrumentation; D005260:Female; D006801:Humans; D008297:Male; D009058:Mouth Breathing; D009296:Nasal Cavity; D009569:Nitric Oxide / Q000032:analysis*; D010160:Palate, Soft / Q000502:physiology*; D012015:Reference Standards; D012016:Reference Values; D015203:Reproducibility of Results; D055815:Young Adult
chemical_list: D009569:Nitric Oxide