title: Immunohistochemical Expression of Myeloperoxidase in Placental Samples of Systematic Lupus Erythematosus Pregnancies.
abstract: OBJECTIVE
  Reports of increased level of Myeloperoxidase (MPO) in plasma and placental extracts of Systematic Lupus Erythematosus (SLE) has been proposed that MPO may have an important role in this pregnancy complication. In present study immunohistochemical MPO expression was investigated in placental samples of SLE women compared with normal controls.
  
  
  METHODS
  Ten patients with SLE were recruited as case group. Control group was selected from mothers with normal uncomplicated pregnancies. A monoclonal antibody specific for MPO was used for immunohistochemical staining and then the staining was quantified and differences between groups were compared using Mann-Whitney U test.
  
  
  RESULTS
  There were significant differences in the expression levels of MPO in the syncytiotrophoblast cells and the extravillous trophoblast cells between the control and SLE groups (p < 0.05). There were no significant differences in the expression level of MPO in the vascular endothelium and the relative number of the MPO-positive leukocytes in placental tissue between SLE and control groups (p > 0.05).
  
  
  CONCLUSIONS
  The present study showed that MPO expression is increased in syncytiotrophoblast cells and the extravillous trophoblast cells of SLE placentas compared to healthy subjects. It seems that these changes are able to impress structure and function of placenta and survival of the fetus.
authors.affiliation: Infectious Diseases and Tropical Medicine Research Center AND Department of Histology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Heidari
authors.affiliation: Infectious Diseases and Tropical Medicine Research Center AND Department of Histology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Mahmoudzadeh Sagheb
authors.affiliation: Department of Histology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: Nadia
authors.initials: N
authors.lastname: Sheibak
keywords: Immunohistochemistry; Lupus Erythematosus; Peroxidase; Placenta; Pregnancy Complications; Trophoblasts