title: Evaluation of Pipeline Flex delivery system for the treatment of unruptured aneurysms.
abstract: Refinements in endovascular technology have revolutionized the treatment of intracranial aneurysms (IAs) with the development of flow-diversion technology. The first generation of the Pipelin Embolization Device (PED) has demonstrated its safety and efficacy. However, the deployment technique was a difficult task that often led to complex maneuvers. The Pipeline Flex Embolization Device (PED Flex) is the second generation and its introduction has arrived with high expectations due to a completely redesigned delivery system that intends to overcome deployment difficulties seen in the previous generation. Areas covered: Preclinical studies, mechanism of action of flow-diverters, technical aspects and deployment system of the PED Flex, and clinical outcomes with both PED generations. Expert commentary: Flow diversion has allowed us to treat lesions that would be otherwise challenging for surgical clipping or unsuitable for other endosaccular strategies. Although the experience with PED Flex is limited, initial results suggest its safety and short-term efficacy.
authors.affiliation: a Lyerly Neurosurgery , Baptist Health , Jacksonville , FL , USA.
authors.forename: Pedro
authors.initials: P
authors.lastname: Aguilar-Salinas
authors.affiliation: b Division of Neurosurgery , University of Arizona , Tucson , AZ , USA.
authors.forename: Leonardo B C
authors.initials: LB
authors.lastname: Brasiliense
authors.affiliation: a Lyerly Neurosurgery , Baptist Health , Jacksonville , FL , USA.
authors.forename: Douglas
authors.initials: D
authors.lastname: Gonsales
authors.affiliation: a Lyerly Neurosurgery , Baptist Health , Jacksonville , FL , USA.
authors.forename: Bartley
authors.initials: B
authors.lastname: Mitchell
authors.affiliation: a Lyerly Neurosurgery , Baptist Health , Jacksonville , FL , USA.
authors.forename: Andrey
authors.initials: A
authors.lastname: Lima
authors.affiliation: a Lyerly Neurosurgery , Baptist Health , Jacksonville , FL , USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Sauvageau
authors.affiliation: a Lyerly Neurosurgery , Baptist Health , Jacksonville , FL , USA.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Hanel
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D004621:Embolization, Therapeutic / Q000295:instrumentation*; D006801:Humans; D002532:Intracranial Aneurysm / Q000628:therapy*; D016896:Treatment Outcome
keywords: Intracranial aneurysms; endovascular treatment; flow diversion; pipeline flex embolization device; unruptured aneurysms