title: Italian Advisory Board: sFlt-1/PlGF ratio and preeclampsia, state of the art and developments in diagnostic, therapeutic and clinical management.
abstract: Extensive research has been published, showing the usefulness of angiogenic markers in both diagnosis and subsequent prediction and management of preeclampsia and placenta-related disorders. Recent evidence provides a helpful cut off for the Elecsys ratio sFlt-1 to PlGF, that predicts preeclampsia development in women with sign and symptoms, before its clinical onset in the short term. In Europe, no accordance exists for the use of such kind of test in clinical practice; only German guidelines have recently taken it into account, as a diagnostic aid for preeclampsia, in conjunction with other clinical findings. This panel of Italian experts recently met, in order to review the literature and to promote the evaluation of the clinical utility of sFlt-1/PlGF ratio at the Italian country level, as regards: prediction of preeclampsia during the first trimester, prediction or exclusion of new onset or recurrence in patients with risk factors for preeclampsia, triage of patients suffering from gestational hypertension, evaluation of disease severity, prediction of adverse maternal and fetal outcomes.
authors.affiliation: Department of Woman, Mother and Neonate, Buzzi Children's Hospital, Biomedical and Clinical Sciences, School of Medicine, University of Milan, Milan, Italy. Electronic address: daniela.dimartino@asst-fbf-sacco.it.
authors.forename: Daniela
authors.initials: D
authors.lastname: Di Martino
authors.affiliation: Department of Mother and Child, Hospital Luigi Sacco, Center for Fetal Research "Giorgio Pardi", School of Medicine, University of Milan, Milan, Italy.
authors.forename: Irene
authors.initials: I
authors.lastname: Cetin
authors.affiliation: Department of Mother and Child, Hospital of Parma, School of Medicine, University of Parma, Parma, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Frusca
authors.affiliation: Department of Woman, Mother and Neonate, Buzzi Children's Hospital, Biomedical and Clinical Sciences, School of Medicine, University of Milan, Milan, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Ferrazzi
authors.affiliation: Department of Woman, Mother and Neonate, Buzzi Children's Hospital, Biomedical and Clinical Sciences, School of Medicine, University of Milan, Milan, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Fuse'
authors.affiliation: Department of Women's and Children's Health, Hospital of Padova, Padova, Italy.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Gervasi
authors.affiliation: Department of Laboratory Medicine, Hospital of Padova, Padova, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Plebani
authors.affiliation: Department of Mother and Fetus, Hospital of Turin, Obstetrics and Gynecology Unit, School of Medicine, University of Turin, Turin, Italy.
authors.forename: Tullia
authors.initials: T
authors.lastname: Todros
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007558:Italy; D000072483:Placenta Growth Factor / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis* / Q000628:therapy; D011247:Pregnancy; D012307:Risk Factors; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood*
chemical_list: C000608036:PGF protein, human; D000072483:Placenta Growth Factor; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1
keywords: Angiogenic markers; Placenta; Preeclampsia