title: The Risk of Thromboembolism in Users of Antidepressants and Antipsychotics.
abstract: Arterial and venous thromboembolism are common causes of morbidity and mortality in the Western world. Mental disorders are also highly prevalent with a lifetime risk of experiencing any psychiatric disease ranging between 32 % and 37 %. Depression and schizophrenia may increase the risk of thromboembolism through genetic, behavioral, and biological mechanisms. Treatment of psychiatric patients with psychotropic drugs is imperative to improve quality of life and to reduce morbidity and mortality. However, studies have shown that psychotropic drugs themselves may modify the risk of arterial and venous thromboembolism, which should be taken into consideration when using these drugs in clinical practice. This association is, however, multifactorial, complex and susceptible to several confounding factors. Psychotropic drugs are widely prescribed, also among patients with cardiovascular disease. Therefore, understanding the association with thromboembolism and the underlying pathophysiological mechanisms is of major importance and will be reviewed in this chapter.
authors.affiliation: Department of Clinical Epidemiology, Aarhus University Hospital, Skejby, Denmark.|Department of Cardiology, Aarhus University Hospital, Skejby, Denmark.
authors.forename: Kasper
authors.initials: K
authors.lastname: Adelborg
authors.affiliation: Department of Clinical Epidemiology, Aarhus University Hospital, Skejby, Denmark.|Department of Cardiology, Aarhus University Hospital, Skejby, Denmark.
authors.forename: Jens
authors.initials: J
authors.lastname: Sundbøll
authors.affiliation: Mental Health Center Glostrup, Glostrup, Denmark.
authors.forename: Poul
authors.initials: P
authors.lastname: Videbech
authors.affiliation: Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark. erikgrove@dadlnet.dk.|Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark. erikgrove@dadlnet.dk.
authors.forename: Erik L
authors.initials: EL
authors.lastname: Grove
mesh_terms: D000928:Antidepressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003863:Depression / Q000188:drug therapy / Q000503:physiopathology; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control; D006801:Humans; D011788:Quality of Life; D012307:Risk Factors; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D013923:Thromboembolism / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control
chemical_list: D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D017367:Selective Serotonin Reuptake Inhibitors
keywords: Antidepressive agents; Depression; Psychotrophic drugs; Schizophrenia; Serotonin uptake inhibitors; Thromboembolism