title: Aberrant ketolysis fuels hepatocellular cancer progression.
abstract: At odds with their normal counterparts, hepatocellular carcinoma cells efficiently utilize ketone bodies to proliferate despite serum deprivation. These findings, which have been recently published in Cell Research, identify a novel metabolic circuitry through which tumors successfully cope with adverse microenvironmental conditions.
authors.affiliation: Department of Radiation Oncology, Weill Cornell Medical College, New York, NY 10065, USA.|Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France.|INSERM, U1138, 75006 Paris, France.|Université Paris Descartes/Paris V, Sorbonne Paris Cité, 75006 Paris, France.|Université Pierre et Marie Curie/Paris VI, 75006 Paris, France.|Gustave Roussy Comprehensive Cancer Institute, 94805 Villejuif, France.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Galluzzi
authors.affiliation: Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France.|INSERM, U1138, 75006 Paris, France.|Université Paris Descartes/Paris V, Sorbonne Paris Cité, 75006 Paris, France.|Université Pierre et Marie Curie/Paris VI, 75006 Paris, France.|Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Institute, 94805 Villejuif, France.|Pôle de Biologie, Hopitâl Européen George Pompidou, AP-HP, 75015 Paris, France.|Department of Women's and Children's Health, Karolinska University Hospital, 17176 Stockholm, Sweden.
authors.forename: Guido
authors.initials: G
authors.lastname: Kroemer
mesh_terms: D000328:Adult; D006528:Carcinoma, Hepatocellular; D002648:Child; D018450:Disease Progression; D006801:Humans; D007657:Ketone Bodies; D008113:Liver Neoplasms
chemical_list: D007657:Ketone Bodies