title: The Independent and Joint Association of Blood Pressure, Serum Total Homocysteine, and Fasting Serum Glucose Levels With Brachial-Ankle Pulse Wave Velocity in Chinese Hypertensive Adults.
abstract: This study aimed to investigate the independent and joint association of blood pressure (BP), homocysteine (Hcy), and fasting blood glucose (FBG) levels with brachial-ankle pulse wave velocity (baPWV, a measure of arterial stiffness) in Chinese hypertensive adults.The analyses included 3967 participants whose BP, Hcy, FBG, and baPWV were measured along with other covariates. Systolic BP (SBP) was analyzed as 3 categories (SBP < 160 mmHg; 160 to 179 mmHg; ≥ 180 mmHg); Hcy as 3 categories (< 10 μmol/L; 10 to 14.9 μmol/L; ≥ 15.0 μmol/L) and FBG: normal (FBG < 5.6 mmol/L), impaired (5.6 mmol/L ≤ FBG < 7.0 mmol/L), and diabetes mellitus (FBG ≥ 7.0 mmol/L). We performed linear regression analyses to evaluate their associations with baPWV with adjustment for covariables.When analyzed individually, BP, Hcy, and FBG were each associated with baPWV. When BP and FBG were analyzed jointly, the highest baPWV value (mean ± SD: 2227 ± 466 cm/s) was observed in participants with FBG ≥ 7.0 mmol/L and SBP ≥ 180 mmHg (β = 432.5, P < 0.001), and the lowest baPWV value (mean ± SD: 1692 ± 289 cm/s) was seen in participants with NFG and SBP < 160 mmHg. When Hcy and FBG were analyzed jointly, the highest baPWV value (2072 ± 480 cm/s) was observed in participants with FBG ≥ 7.0 mmol/L and Hcy ≥ 15.0 μmol/L (β = 167.6, P < 0.001), while the lowest baPWV value (mean ± SD: 1773 ± 334 cm/s) was observed in participants with NFG and Hcy < 10 μmol/L.In Chinese hypertensive adults, SBP, Hcy, and FBG are individually and jointly associated with baPWV.Our findings underscore the importance of identifying individuals with multiple risk factors of baPWV including high SBP, FBG, and Hcy.
authors.affiliation: Department of Cardiology, Peking University People's Hospital.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Liu
authors.forename: Ningling
authors.initials: N
authors.lastname: Sun
authors.forename: Tao
authors.initials: T
authors.lastname: Yu
authors.forename: Fangfang
authors.initials: F
authors.lastname: Fan
authors.forename: Meili
authors.initials: M
authors.lastname: Zheng
authors.forename: Geng
authors.initials: G
authors.lastname: Qian
authors.forename: Binyan
authors.initials: B
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Genfu
authors.initials: G
authors.lastname: Tang
authors.forename: Jianping
authors.initials: J
authors.lastname: Li
authors.forename: Xianhui
authors.initials: X
authors.lastname: Qin
authors.forename: Fanfan
authors.initials: F
authors.lastname: Hou
authors.forename: Xiping
authors.initials: X
authors.lastname: Xu
authors.forename: Xinchun
authors.initials: X
authors.lastname: Yang
authors.forename: Yundai
authors.initials: Y
authors.lastname: Chen
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Wang
authors.forename: Yong
authors.initials: Y
authors.lastname: Huo
mesh_terms: D000328:Adult; D000368:Aged; D055109:Ankle Brachial Index; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure / Q000502:physiology; D002681:China; D003430:Cross-Sectional Studies; D005215:Fasting / Q000097:blood; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000208:ethnology / Q000503:physiopathology*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis
chemical_list: D001786:Blood Glucose; D006710:Homocysteine