title: Overexpression of Paxillin Correlates with Tumor Progression and Predicts Poor Survival in Glioblastoma.
abstract: OBJECTIVE
  To explore the prognostic and clinicopathological features of glioma with Paxillin (PXN) expression based on a large number of samples.
  
  
  METHODS
  RNA sequencing data of 325 glioma samples from Chinese Glioma Genome Atlas (CGGA) database were obtained as discovery set. Three additional datasets were further obtained as validation sets. The protein expression pattern of PXN in glioma was measured by IHC. Kaplan-Meier survival and multivariate Cox analysis were used to estimate the survival distributions. Moreover, the functional annotation of PXN was also analyzed.
  
  
  RESULTS
  In the discovery set, PXN overexpression was significantly associated with high-grade glioma as well as the higher mortality in survival analysis (log-rank test, P < 0.01). The results of the other validation datasets showed similar findings. PXN also served as an independent prognostic biomarker in glioblastoma patients. Functional assays showed that PXN contributed to glioma cell proliferation and invasion.
  
  
  CONCLUSIONS
  PXN plays as an oncogene in glioma progression and suggests a new potential biotarget for therapy.
authors.affiliation: Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.|Department of Neurosurgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Sun
authors.affiliation: Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
authors.forename: Fu-Qiang
authors.initials: FQ
authors.lastname: Yang
authors.affiliation: Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
authors.forename: Chuan-Bao
authors.initials: CB
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Wu
authors.affiliation: Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
authors.forename: Jing-Shan
authors.initials: JS
authors.lastname: Liang
authors.affiliation: Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Jin
authors.affiliation: Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, 2nd affiliated hospital of Harbin Medical University, Harbin, China.
authors.forename: Hong-Jun
authors.initials: HJ
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: Zhao-Shi
authors.initials: ZS
authors.lastname: Bao
authors.affiliation: Department of Neurosurgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.
authors.forename: Zheng-Xiang
authors.initials: ZX
authors.lastname: Yang
authors.affiliation: Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.|Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.|Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing, China.|China National Clinical Research Center for Neurological Diseases, Beijing, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000368:Aged; D017209:Apoptosis / Q000502:physiology; D001932:Brain Neoplasms / Q000378:metabolism* / Q000401:mortality*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D030561:Databases, Nucleic Acid; D018450:Disease Progression; D005260:Female; D005909:Glioblastoma / Q000378:metabolism* / Q000401:mortality*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D051419:Paxillin / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D034741:RNA, Small Interfering / Q000494:pharmacology
chemical_list: D051419:Paxillin; D012333:RNA, Messenger; D034741:RNA, Small Interfering
keywords: 
  PXN
  ; Glioma; Oncogene; Prognosis