title: Concepts in mature T-cell lymphomas - highlights from an international joint symposium on T-cell immunology and oncology<sup/>.
abstract: Growing attention in mature T-cell lymphomas/leukemias (MTCL) is committed to more accurate and meaningful classifications, improved pathogenetic concepts and expanded therapeutic options. This requires considerations of the immunologic concepts of T-cell homeostasis and the specifics of T-cell receptor (TCR) affinities and signaling. Scientists from various disciplines established the CONTROL-T research unit and in an international conference on MTCL they brought together experts from T-cell immunity, oncology, immunotherapy and systems biology. We report here meeting highlights on the covered topics of diagnostic pitfalls, implications by the new WHO classification, insights from discovered genomic lesions as well as TCR-centric concepts of cellular dynamics in host defense, auto-immunity and tumorigenic clonal escape, including predictions to be derived from in vivo imaging and mathematical modeling. Presentations on novel treatment approaches were supplemented by strategies of optimizing T-cell immunotherapies. Work packages, that in joint efforts would advance the field of MTCL more efficiently, are identified.
authors.affiliation: a Department of Internal Medicine, Center for Integrated Oncology (CIO) Köln-Bonn, Excellence Cluster for Cellular Stress Response and Aging-Associated Diseases (CECAD) , University of Cologne , Cologne , Germany.
authors.forename: Marco
authors.initials: M
authors.lastname: Herling
authors.affiliation: b Dr. Senckenberg Institute of Pathology, Goethe-University , Frankfurt/M , Germany.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Rengstl
authors.affiliation: c Institute of Cell Biology (Cancer Research), University of Duisburg-Essen , Essen , Germany.
authors.forename: René
authors.initials: R
authors.lastname: Scholtysik
authors.affiliation: b Dr. Senckenberg Institute of Pathology, Goethe-University , Frankfurt/M , Germany.
authors.forename: Sylvia
authors.initials: S
authors.lastname: Hartmann
authors.affiliation: c Institute of Cell Biology (Cancer Research), University of Duisburg-Essen , Essen , Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Küppers
authors.affiliation: b Dr. Senckenberg Institute of Pathology, Goethe-University , Frankfurt/M , Germany.
authors.forename: Martin-Leo
authors.initials: ML
authors.lastname: Hansmann
authors.affiliation: d Faculty of Medicine Carl Gustav Carus , Technische Universität Dresden, Institute for Medical Informatics and Biometry , Dresden , Germany.
authors.forename: Hans H
authors.initials: HH
authors.lastname: Diebner
authors.affiliation: d Faculty of Medicine Carl Gustav Carus , Technische Universität Dresden, Institute for Medical Informatics and Biometry , Dresden , Germany.
authors.forename: Ingo
authors.initials: I
authors.lastname: Roeder
authors.affiliation: a Department of Internal Medicine, Center for Integrated Oncology (CIO) Köln-Bonn, Excellence Cluster for Cellular Stress Response and Aging-Associated Diseases (CECAD) , University of Cologne , Cologne , Germany.|e Center for Molecular Medicine Cologne, University of Cologne , Cologne , Germany.
authors.forename: Hinrich
authors.initials: H
authors.lastname: Abken
authors.affiliation: b Dr. Senckenberg Institute of Pathology, Goethe-University , Frankfurt/M , Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Newrzela
authors.affiliation: f Division of Immunology , Paul-Ehrlich-Institute , Langen , Germany.
authors.forename: Jörg
authors.initials: J
authors.lastname: Kirberg
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D019468:Disease Management; D006801:Humans; D007167:Immunotherapy; D016399:Lymphoma, T-Cell / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology / Q000628:therapy; D060787:Neoplasm Grading; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D014944:World Health Organization
keywords: Chimeric antigen receptor T-cell; T-cell homeostasis; T-cell immunotherapy; T-cell leukemia; T-cell lymphoma; T-cell receptor