title: Clinical features and surgical treatment for Chinese juvenile onset current respiratory papillomatosis (JORRP).
abstract: Juvenile onset current respiratory papillomatosis (JORRP), which is the commonest benign laryngeal disease in children, has not been well investigated. This study aimed at further evaluating the clinical features and surgery for such children with JORRP. Patients diagnosed as JORRP in our department from January 2011 to June 2014 were enrolled, and the demographic and clinical data were collected. All the patients were followed up after surgery, and the recurrences were recorded. A total of 124 patients were included and categorized into low recurrence (<4/year, n = 97) and high recurrence (≥4/year, n = 27) groups based on the recurrence at diagnosis, respectively. The demographic characteristics were comparable in two groups. There were more patients in high recurrence group who had dyspnea II-III, abnormal chest X-ray findings and severe illness, and needed electrocardiscope monitoring (P < 0.05). Patients who had dyspnea II (P = 0.008) and severe illness (P = 0.002) needed electrocardiscope monitoring (P = 0.014) in high recurrence group were more prone to have recurrence after surgery. Multivariate logistic regression analysis proved that high recurrence at diagnosis was an independent risk factor for recurrence after surgery in JORRP [95 %CI OR 17.342 (1.266, 237.608), P = 0.033]. The recurrence at diagnosis could be used as a prognostic factor for JORRP after surgery, which could help to improve the therapeutic efficacy in such children.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.|Ministry of Education, Key Laboratory of Otolaryngology Head and Neck Surgery, Capital Medical University, Beijing, 100730, China.
authors.forename: Weixin
authors.initials: W
authors.lastname: Cui
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China. xuwendoc@126.com.|Ministry of Education, Key Laboratory of Otolaryngology Head and Neck Surgery, Capital Medical University, Beijing, 100730, China. xuwendoc@126.com.
authors.forename: Wen
authors.initials: W
authors.lastname: Xu
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.|Ministry of Education, Key Laboratory of Otolaryngology Head and Neck Surgery, Capital Medical University, Beijing, 100730, China.
authors.forename: Qingwen
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.|Ministry of Education, Key Laboratory of Otolaryngology Head and Neck Surgery, Capital Medical University, Beijing, 100730, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Hu
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002681:China; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007223:Infant; D007818:Laryngeal Diseases / Q000601:surgery*; D008297:Male; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000601:surgery*; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000601:surgery*; D012307:Risk Factors
keywords: Diagnosis; Juvenile onset current respiratory papillomatosis; Outcome; Surgery