title: Efficacy of platelet rich fibrin in the treatment of human intrabony defects with or without bone graft: A randomized controlled trial.
abstract: OBJECTIVE
  To evaluate the efficacy of platelet rich fibrin (PRF) with or without bone graft [demineralized bone matrix (DBM) graft] in the treatment of intrabony defects based on clinical and radiographic parameters.
  
  
  METHODS
  Thirty six intrabony defects in 36 patients were randomly divided into three different groups and were treated with group A (PRF with DBM) or group B (PRF alone) or group C [open flap debridement (OFD)]. Clinical parameters such as plaque index (PI), gingival index (GI), probing depth (PD), relative attachment level (RAL), and gingival recession (GR) were assessed at baseline and 9 months postoperatively; radiographic parameters such as linear bone growth (LBG) and percentage in bone fill (%BF) were calculated by using the image analysis software. Comparisons of groups were analyzed using Kruskal-Wallis analysis of variance test. Pair-wise comparison of groups was done by Mann-Whitney U test.
  
  
  RESULTS
  Mean PD reduction and RAL gain were greater in group A (4.25 ± 1.48, 3.92 ± 0.90) and group B (3.82 ± 0.75, 3.27 ± 0.65) than control (3.00 ± 1.21, 2.25 ± 0.62). Furthermore, statistically significant improvement in LBG and %BF was found in group A (3.47 ± 0.53, 61.53 ± 4.54) compared to group B (2.55 ± 0.61, 49.60 ± 14.08) and group C (1.21 ± 0.80, 24.69 ± 15.59).
  
  
  CONCLUSIONS
  The study demonstrated that PRF improves clinical and radiological parameters compared to OFD alone in intrabony defects. Addition of DBM enhances the effects of PRF in RAL gain and radiographic defect fill.
authors.affiliation: Department of Periodontics, Sree Mookambika Institute of Dental Sciences, Padanilam, Kulasekharam, Kanyakumari, India.
authors.forename: Nikhil D
authors.initials: ND
authors.lastname: Chandradas
authors.affiliation: Department of Periodontics, Sri Hasanamba Dental College and Hospital, Vidyanagar, Hassan, India.
authors.forename: Shivamurthy
authors.initials: S
authors.lastname: Ravindra
authors.affiliation: Department of Periodontics, Sri Hasanamba Dental College and Hospital, Vidyanagar, Hassan, India.
authors.forename: Vivekananda M
authors.initials: VM
authors.lastname: Rangaraju
authors.affiliation: Sumukha Orofacial and Dental Care, Hassan, Karnataka, India.
authors.forename: Sheetal
authors.initials: S
authors.lastname: Jain
authors.affiliation: Department of Periodontics, Sri Hasanamba Dental College and Hospital, Vidyanagar, Hassan, India.
authors.forename: Shivaprasad
authors.initials: S
authors.lastname: Dasappa
keywords: Chronic periodontitis; clinical trial; periodontal attachment loss; platelet-derived growth factor; regeneration