title: Pestalotic acids A-I, antibacterial ambuic acid analogues, from a mycoparasite (Pestalotipsis sp. cr014) of Cronartium ribicola.
abstract: The white pine blister rust caused by Cronartium ribicola is a severe disease of Pinus armandii Franch in Sichuan Province, China. A mycoparasite was isolated from aeciospore piles of C. ribicola and identified as Pestalotipsis sp. The chemical constituents were investigated and nine new polyketides, named pestalotic acids A-I (1-9), were isolated from solid fermentation products of Pestalotiopsis sp. cr014. Their structures were elucidated by extensive spectroscopic methods, including 1D- and 2D- NMR, HR-MS experiments. Compounds 2-5 and 7-9 exhibited strong antibacterial activities in vitro against five plant pathogens, with minimum inhibitory concentration values of 0.78-100 µg/mL.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, China.|Life Science College, Southwest Forestry University, Kunming, 650224, China.|University of Chinese Academy of Sciences, Beijing, 100049, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, China.|Life Science College, Southwest Forestry University, Kunming, 650224, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Xie
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, China.
authors.forename: Fei-Xue
authors.initials: FX
authors.lastname: Yu
authors.affiliation: Life Science College, Southwest Forestry University, Kunming, 650224, China.
authors.forename: Yu-Hui
authors.initials: YH
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, China. Pjzhao@outlook.com.|State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, 650091, China. Pjzhao@outlook.com.
authors.forename: Pei-Ji
authors.identifier: http://orcid.org/0000-0003-4612-1257
authors.initials: PJ
authors.lastname: Zhao
keywords: Antibacterial activity; Pestalotic acid; Pestalotiopsis sp. cr014; Plant pathogen; Polyketide