title: Ultrafast in cellulo photoinduced dynamics processes of the paradigm molecular light switch [Ru(bpy)2dppz](2.).
abstract: An in cellulo study of the ultrafast excited state processes in the paradigm molecular light switch [Ru(bpy)2dppz](2+) by localized pump-probe spectroscopy is reported for the first time. The localization of [Ru(bpy)2dppz](2+) in HepG2 cells is verified by emission microscopy and the characteristic photoinduced picosecond dynamics of the molecular light switch is observed in cellulo. The observation of the typical phosphorescence stemming from a (3)MLCT state suggests that the [Ru(bpy)2dppz](2+) complex intercalates with the DNA in the nucleus. The results presented for this benchmark coordination compound reveal the necessity to study the photoinduced processes in coordination compounds for intracellular use, e.g. as sensors or as photodrugs, in the actual biological target environment in order to derive a detailed molecular mechanistic understanding of the excited-state properties of the systems in the actual biological target environment.
authors.affiliation: Leibniz-Institute of Photonic Technology Jena, Albert-Einstein-Straße 9, 07745 Jena, Germany.|Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University Jena, Helmholtzweg 4, 07743 Jena, Germany.
authors.forename: Alejandro
authors.initials: A
authors.lastname: De la Cadena
authors.affiliation: Leibniz-Institute of Photonic Technology Jena, Albert-Einstein-Straße 9, 07745 Jena, Germany.|Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University Jena, Helmholtzweg 4, 07743 Jena, Germany.
authors.forename: Dar'ya
authors.initials: D
authors.lastname: Davydova
authors.affiliation: Leibniz-Institute of Photonic Technology Jena, Albert-Einstein-Straße 9, 07745 Jena, Germany.|Department of Internal Medicine IV, Division of Gastroenterology, Hepatology and Infectious Diseases, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Tolstik
authors.affiliation: Leibniz-Institute of Photonic Technology Jena, Albert-Einstein-Straße 9, 07745 Jena, Germany.|Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University Jena, Helmholtzweg 4, 07743 Jena, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Reichardt
authors.affiliation: Leibniz-Institute of Photonic Technology Jena, Albert-Einstein-Straße 9, 07745 Jena, Germany.|Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University Jena, Helmholtzweg 4, 07743 Jena, Germany.
authors.forename: Sapna
authors.initials: S
authors.lastname: Shukla
authors.affiliation: Leibniz-Institute of Photonic Technology Jena, Albert-Einstein-Straße 9, 07745 Jena, Germany.
authors.forename: Denis
authors.initials: D
authors.lastname: Akimov
authors.affiliation: Leibniz-Institute of Photonic Technology Jena, Albert-Einstein-Straße 9, 07745 Jena, Germany.|Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University Jena, Helmholtzweg 4, 07743 Jena, Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Heintzmann
authors.affiliation: Leibniz-Institute of Photonic Technology Jena, Albert-Einstein-Straße 9, 07745 Jena, Germany.|Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University Jena, Helmholtzweg 4, 07743 Jena, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Popp
authors.affiliation: Leibniz-Institute of Photonic Technology Jena, Albert-Einstein-Straße 9, 07745 Jena, Germany.|Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University Jena, Helmholtzweg 4, 07743 Jena, Germany.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Dietzek