title: Fractionated stereotactic radiosurgery for vestibular schwannomas using cyberknife: A single institution experience.
abstract: To assess tumour control, hearing preservation status, and complication ratio after fractionated stereotactic radiosurgery/radiotherapy by using CyberKnife device in patients with vestibular schwannomas.
  
  
  
  This retrospective study was conducted at Izmir Ataturk Research and Tranining Hospital, Turkey, and comprised data of vestibular schwannomas patients treated with stereotactic radiosurgery/radiotherapy from March 2010 to December 2013. The patients were subjected to a dose ranging from 12 to 30Gy using CyberKnife system with an average of three fractions. SPSS 17 was used for data analysis. Paired t-test and Pearson's chi-square test were used to compare clinical parameters between groups. P<0.05 was considered significant.
  
  
  
  Of the 41 patients, 26(63.4%) were women and 15(36.6%) were men. The median follow-up duration after stereotactic radiosurgery/radiotherapy was 25 months (interquartile range: 9-44 months). Radiographic control evaluation ratio was 95.7% with a median follow-up of 3 years (IQR: 18.5 months). Results of 23(56%) patients showed stabile response, 17(42%) regression response and 1(2%) progression response. There were no statistically significant changes between pre- and post-stereotactic radiosurgery/radiotherapy symptoms (p>0.05). One (2.4%) patient reported new onset facial paresis.
  
  
  
  Stereotactic radiosurgery/radiotherapy treatment of vestibular schwannomas resulted in a good ratio of tumour control. Hearing preservation status and ratios of toxicity were comparable to published literature.
authors.affiliation: Department of Radiation Oncology, Ataturk Education and Research Hospital, Katip Celebi University, Izmir, Turkey.
authors.forename: Mihriban Erdogan
authors.initials: ME
authors.lastname: Kocak
authors.affiliation: Department of Radiation Oncology, Ataturk Education and Research Hospital, Katip Celebi University, Izmir, Turkey. ).
authors.forename: Adem
authors.initials: A
authors.lastname: Sengul
authors.affiliation: Department of Radiation Oncology, Medical Faculty, Inonu University, Malatya, Turkey.
authors.forename: Kemal
authors.initials: K
authors.lastname: Ekici
authors.affiliation: Department of Radiation Oncology, Ataturk Education and Research Hospital, Katip Celebi University, Izmir, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Olmezoglu
authors.affiliation: Department of Radiation Oncology, Memorial Hospital, Diyarbakir, Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Seseogullari
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009464:Neuroma, Acoustic / Q000601:surgery*; D016634:Radiosurgery; D012189:Retrospective Studies; D016896:Treatment Outcome; D014421:Turkey
keywords:  Vestibular schwannoma, Cyberknife, Stereotactic radiosurgery, Stereotactic radiotherapy.