title: Clinical efficacy and safety of hypernormal shortened door to needle time (DNT) plus individualized low-dose alteplase therapy in treating acute ischemic stroke.
abstract: OBJECTIVE
  This study aims to observe the clinical efficacies of hyper-early low-dose alteplase thrombolysis in treating acute ischemic stroke (AIS).
  
  
  METHODS
  Two hundred twenty AIS patients were randomly divided into group A (90 cases), group B (90 cases), and group C (40 cases). The National Institutes of Health Stroke Scale (NIHSS) scores, mRS score-evaluated prognosis, intracranial hemorrhage, and mortality of the three groups were observed before and after the treatment.
  
  
  RESULTS
  The NIHSS scores of the three groups were significantly reduced after the treatment (P<0.05), among which the NIHSS score of group A was the lowest (P<0.05); and the difference between group B and C was not significant (P>0.05). The incidence of such complications as cerebral hemorrhage in the three groups was low, and there was no significant difference among the groups (P>0.05). The modified Rankin Scale (mRS)scores of the three groups showed that group A had much better prognosis than group B and C, while the difference between group B and group C was not significant.
  
  
  CONCLUSIONS
  The hyper-early low-dose alteplase thrombolysis was safe and effective in Acute ischemic stroke (AIS).
authors.affiliation: Yansen Cui, Department of Emergency, Linyi People's Hospital, Linyi 276000, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Zheng
authors.affiliation: Hongyan Lei, Department of Emergency, Linyi People's Hospital, Linyi 276000, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Lei
authors.affiliation: Yansen Cui, Department of Emergency, Linyi People's Hospital, Linyi 276000, China.
authors.forename: Yansen
authors.initials: Y
authors.lastname: Cui
authors.affiliation: Daiqun Yang, Department of Emergency, Linyi People's Hospital, Linyi 276000, China.
authors.forename: Daiqun
authors.initials: D
authors.lastname: Yang
authors.affiliation: Liquang Wang, Department of Emergency, Linyi People's Hospital, Linyi 276000, China.
authors.forename: Liquang
authors.initials: L
authors.lastname: Wang
authors.affiliation: Ziran Wang, Department of Emergency, Linyi People's Hospital, Linyi 276000, China.
authors.forename: Ziran
authors.initials: Z
authors.lastname: Wang
keywords: Acute ischemic stroke; Alteplase; Efficacy and safety; Hypernormal shortened DNT