title: Enterococcus faecium strain L-3 and glatiramer acetate ameliorate experimental allergic encephalomyelitis in rats by affecting different populations of immune cells.
abstract: The effect of probiotic Enterococcus faecium strain L-3 was studied in rats with experimental allergic encephalomyelitis (EAE). Glatiramer acetate (GA) was used as control drug. E. faecium strain L-3 and GA both were able to reduce the severity of EAE in a similar fashion. Both approaches increased the proportion of EAE resistant rats and rats with mild disease, prolonged the inductive phase of EAE and reduced the disease duration. Study of the phenotypes of immune cells in blood revealed the differences in immunoregulatory pathways that mediate the protective action of probiotic or GA treatment of EAE. The presence of pronounced protective and immunomodulating effects of the probiotic E. faecium strain L-3 opens an opportunity of its application for the treatment of multiple sclerosis.
authors.affiliation: 1 Institute of Experimental Medicine, 12 Academician Pavlov St., 197376 St.-Petersburg, Russian Federation.|2 Saint-Petersburg State Pediatric Medical University, 2 Lithuanian St., 194100 St.-Petersburg, Russian Federation.
authors.forename: I N
authors.initials: IN
authors.lastname: Abdurasulova
authors.affiliation: 1 Institute of Experimental Medicine, 12 Academician Pavlov St., 197376 St.-Petersburg, Russian Federation.
authors.forename: A V
authors.initials: AV
authors.lastname: Matsulevich
authors.affiliation: 1 Institute of Experimental Medicine, 12 Academician Pavlov St., 197376 St.-Petersburg, Russian Federation.|3 Research laboratory 'Explana', 14a Academician Pavlov St., 197376 St.-Petersburg, Russian Federation.
authors.forename: E A
authors.initials: EA
authors.lastname: Tarasova
authors.affiliation: 1 Institute of Experimental Medicine, 12 Academician Pavlov St., 197376 St.-Petersburg, Russian Federation.|4 School of Biomedicine of Far Eastern Federal University, 8 Sukhanova St., 690950 Vladivostok, Russian Federation.
authors.forename: I V
authors.initials: IV
authors.lastname: Kudryavtsev
authors.affiliation: 1 Institute of Experimental Medicine, 12 Academician Pavlov St., 197376 St.-Petersburg, Russian Federation.|5 ITMO University, 49 Kronverksky Pr., 197101 St.-Petersburg, Russian Federation.
authors.forename: M K
authors.initials: MK
authors.lastname: Serebrjakova
authors.affiliation: 1 Institute of Experimental Medicine, 12 Academician Pavlov St., 197376 St.-Petersburg, Russian Federation.|6 Saint-Petersburg State University, 7-9 University Em., 199034 St.-Petersburg, Russian Federation.
authors.forename: E I
authors.initials: EI
authors.lastname: Ermolenko
authors.affiliation: 7 Kirov Military Medical Academy, 6 Academician Lebedev St., 194044 St.-Petersburg, Russian Federation.
authors.forename: G N
authors.initials: GN
authors.lastname: Bisaga
authors.affiliation: 1 Institute of Experimental Medicine, 12 Academician Pavlov St., 197376 St.-Petersburg, Russian Federation.
authors.forename: V M
authors.initials: VM
authors.lastname: Klimenko
authors.affiliation: 1 Institute of Experimental Medicine, 12 Academician Pavlov St., 197376 St.-Petersburg, Russian Federation.|6 Saint-Petersburg State University, 7-9 University Em., 199034 St.-Petersburg, Russian Federation.
authors.forename: A N
authors.initials: AN
authors.lastname: Suvorov
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D016984:Enterococcus faecium; D005260:Female; D000068717:Glatiramer Acetate / Q000494:pharmacology*; D056747:Immunomodulation; D009103:Multiple Sclerosis / Q000188:drug therapy*; D010455:Peptides / Q000494:pharmacology; D019936:Probiotics / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010455:Peptides; D000068717:Glatiramer Acetate
keywords: Enterococcus faecium; experimental allergic encephalomyelitis; immunomodulation; intestinal microbiota; multiple sclerosis; neuroprotection; probiotics