title: Dynamic GABAergic afferent modulation of AgRP neurons.
abstract: Agouti-related peptide (AgRP) neurons of the arcuate nucleus of the hypothalamus (ARC) promote homeostatic feeding at times of caloric insufficiency, yet they are rapidly suppressed by food-related sensory cues before ingestion. Here we identify a highly selective inhibitory afferent to AgRP neurons that serves as a neural determinant of this rapid modulation. Specifically, GABAergic projections arising from the ventral compartment of the dorsomedial nucleus of the hypothalamus (vDMH) contribute to the preconsummatory modulation of ARCAgRPneurons. In a manner reciprocal to ARCAgRPneurons, ARC-projecting leptin receptor-expressing GABAergic vDMH neurons exhibit rapid activation upon availability of food that additionally reflects the relative value of the food. Thus, leptin receptor-expressing GABAergic vDMH neurons form part of the sensory network that relays real-time information about the nature and availability of food to dynamically modulate ARCAgRPneuron activity and feeding behavior.
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.|Centre for Integrative Physiology, Hugh Robson Building, University of Edinburgh, Edinburgh, UK.
authors.forename: Alastair S
authors.initials: AS
authors.lastname: Garfield
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Bhavik P
authors.initials: BP
authors.lastname: Shah
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Christian R
authors.initials: CR
authors.lastname: Burgess
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Monica M
authors.initials: MM
authors.lastname: Li
authors.affiliation: Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.|National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA.
authors.forename: Chia
authors.initials: C
authors.lastname: Li
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Steger
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Madara
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: John N
authors.initials: JN
authors.lastname: Campbell
authors.affiliation: Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Kroeger
authors.affiliation: Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Scammell
authors.affiliation: Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
authors.forename: Bakhos A
authors.initials: BA
authors.lastname: Tannous
authors.affiliation: Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.|Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA.
authors.forename: Martin G
authors.initials: MG
authors.lastname: Myers
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Mark L
authors.initials: ML
authors.lastname: Andermann
authors.affiliation: Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.|National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Krashes
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Bradford B
authors.initials: BB
authors.lastname: Lowell
mesh_terms: D054369:Agouti-Related Protein / Q000378:metabolism*; D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000378:metabolism*; D005247:Feeding Behavior; D059330:GABAergic Neurons / Q000378:metabolism*; D051379:Mice; D009478:Neuropeptide Y / Q000378:metabolism; D054411:Receptors, Leptin / Q000378:metabolism; D012677:Sensation / Q000502:physiology
chemical_list: D054369:Agouti-Related Protein; D009478:Neuropeptide Y; D054411:Receptors, Leptin