title: Reproducibility and repeatability of foveal avascular zone area measurements using swept-source optical coherence tomography angiography in healthy subjects.
abstract: OBJECTIVE
  To assess the reproducibility and repeatability of foveal avascular zone (FAZ) area measurements using swept-source optical coherence tomography angiography (SS-OCTA) in healthy subjects.
  
  
  METHODS
  Sixty-four eyes of 64 healthy volunteers were randomly subjected to FAZ area measurements using SS-OCTA by 2 examiners in 2 different sessions.
  
  
  RESULTS
  The FAZ areas measured by the first and second observer were 0.269 ± 0.092 mm2 and 0.270 ± 0.090 mm2, respectively. Within subjects, the coefficients of variations were 2.44% (95% confidence interval [CI] 1.95% to 2.93%) and 2.66% (95% CI 2.00% to 3.31%) for the first and second observers, respectively. The coefficient of repeatability average measurements of FAZ area were 0.021 mm2 and 0.024 mm2. The intraclass correlation coefficient values were 0.993 (95% CI 0.989 to 0.996) and 0.991 (95% CI 0.986 to 0.995). Interobserver and intraobserver concordance correlation coefficients ranged from 0.998 (95% CI 0.997 to 0.999) to 0.999 (95% CI 0.998 to 0.999) and from 0.989 (95% CI 0.982 to 0.993) to 0.987 (95% CI 0.979 to 0.992), respectively.
  
  
  CONCLUSIONS
  The FAZ area measurements by means of SS-OCTA showed high reproducibility and repeatability in healthy eyes.
authors.affiliation: Ophthalmology Clinic, Moorfields Eye Hospital, London - UK.
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Mastropasqua
authors.affiliation: Ophthalmology Clinic, Department of Medicine and Aging Sciences, High-Tech National Center in Ophthalmology, University "G. d'Annunzio" Chieti-Pescara, Chieti - Italy.
authors.forename: Lisa
authors.initials: L
authors.lastname: Toto
authors.affiliation: Ophthalmology Clinic, Department of Medicine and Aging Sciences, High-Tech National Center in Ophthalmology, University "G. d'Annunzio" Chieti-Pescara, Chieti - Italy.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Mattei
authors.affiliation: Department of Experimental and Clinical Sciences, Laboratory of Biostatistics, University "G. d'Annunzio" Chieti-Pescara, Chieti - Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Di Nicola
authors.affiliation: Department of Experimental and Clinical Sciences, Laboratory of Biostatistics, University "G. d'Annunzio" Chieti-Pescara, Chieti - Italy.
authors.forename: Isaia A L
authors.initials: IAL
authors.lastname: Zecca
authors.affiliation: Ophthalmology Clinic, Department of Medicine and Aging Sciences, High-Tech National Center in Ophthalmology, University "G. d'Annunzio" Chieti-Pescara, Chieti - Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Carpineto
authors.affiliation: Ophthalmology Clinic, Department of Medicine and Aging Sciences, High-Tech National Center in Ophthalmology, University "G. d'Annunzio" Chieti-Pescara, Chieti - Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Di Antonio
mesh_terms: D000328:Adult; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D005584:Fovea Centralis / Q000166:cytology*; D005654:Fundus Oculi; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D015203:Reproducibility of Results; D012171:Retinal Vessels / Q000166:cytology*; D041623:Tomography, Optical Coherence / Q000379:methods*; D055815:Young Adult