title: Principles of vestibular pharmacotherapy.
abstract: Ideally, vestibular pharmacotherapy is intended, through specific and targeted molecular actions, to significantly alleviate vertigo symptoms, to protect or repair the vestibular sensory network under pathologic conditions, and to promote vestibular compensation, with the eventual aim of improving the patient's quality of life. In fact, in order to achieve this aim, considerable progress still needs to be made. The lack of information on the etiology of vestibular disorders and the pharmacologic targets to modulate, as well as the technical challenge of targeting a drug to its effective site are some of the main issues yet to be overcome. In this review, my intention is to provide an account of the therapeutic principles that have shaped current vestibular pharmacotherapy and to further explore crucial questions that must be taken into consideration in order to develop targeted and specific pharmacologic therapies for each type and stage of vestibular disorders.
authors.affiliation: Integrative and Adaptative Neurosciences, University of Aix Marseille, Marseille, France. Electronic address: christian.chabbert@univ-amu.fr.
authors.forename: C
authors.initials: C
authors.lastname: Chabbert
mesh_terms: D018692:Antimanic Agents / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D018680:Cholinergic Antagonists / Q000627:therapeutic use; D004358:Drug Therapy / Q000379:methods*; D006801:Humans; D008954:Models, Biological; D015837:Vestibular Diseases / Q000188:drug therapy*
chemical_list: D018692:Antimanic Agents; D002121:Calcium Channel Blockers; D018680:Cholinergic Antagonists
keywords: antiemetics; antivertiginous drugs; vertigo; vestibular depressants; vestibular disorders