title: Giant Cell Tumor of Bone: Documented Progression over 4 Years from Its Origin at the Metaphysis to the Articular Surface.
abstract: The exact location of origin for giant cell tumors of bone (GCTB) remains controversial, as lesions are not routinely imaged early but rather late when the tumor is large and clinically symptomatic. At the time of diagnosis, GCTB are classically described as lucent, eccentric lesions with nonsclerotic margins, located within the epiphysis to a greater extent than the metaphysis. Here we present a case of a biopsy proven GCTB initially incidentally seen on MRI as a small strictly metaphyseal lesion, which over the course of several years expanded across a closed physis to involve the epiphysis and abut the articular surface/subchondral bone plate.
authors.affiliation: Department of Radiology & Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue, M-391, San Francisco, CA 94143-0628, USA.
authors.forename: Colin
authors.identifier: 0000-0002-5043-8452
authors.initials: C
authors.lastname: Burke
authors.affiliation: Department of Radiology & Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue, M-391, San Francisco, CA 94143-0628, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Link
authors.affiliation: Department of Orthopaedic Surgery, University of California, San Francisco, 1825 Fourth Street, Fourth Floor, San Francisco, CA 94158, USA.
authors.forename: Richard J
authors.identifier: 0000-0002-6366-2701
authors.initials: RJ
authors.lastname: O'Donnell
authors.affiliation: Department of Pathology, University of California, San Francisco, 1825 Fourth Street, Room M2370, San Francisco, CA 94143, USA.
authors.forename: Soo-Jin
authors.initials: SJ
authors.lastname: Cho
authors.affiliation: Department of Radiology & Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue, M-391, San Francisco, CA 94143-0628, USA.
authors.forename: Daria
authors.initials: D
authors.lastname: Motamedi