title: Outbreak of OXA-48-Producing Klebsiella pneumoniae Involving a Sequence Type 101 Clone in Batna University Hospital, Algeria.
abstract: Seven nonredundant ertapenem-resistant Klebsiella pneumoniae isolates were collected between May 2014 and 19 January 2015 in the nephrology and hematology units of Batna University Hospital in Algeria. All strains coproduced the blaOXA-48, blaCTX-M-15, blaSHV-1, and blaTEM-1Dgenes. Six of these isolates belonged to the pandemic clone sequence type 101 (ST101). The blaOXA-48gene was located on a conjugative IncL/M-type plasmid. This is the first known outbreak of OXA-48-producing K. pneumoniae isolates involving an ST101 clone in Batna University Hospital.
authors.affiliation: Laboratoire de Biotechnologie des Molécules Bioactives et de la Physiopathologie Cellulaire (LBMBPC), Faculté des Sciences de la Nature et de la Vie, Université de Batna 2, Batna, Algeria.|Unité de Recherche sur les Maladies Infectieuses et Tropicales Émergentes (URMITE), UM 63, CNRS 7278, IRD 198, INSERM 1095, IHU Méditerranée Infection, Faculté de Médecine et de Pharmacie, Aix-Marseille-Université, Marseille, France.
authors.forename: Lotfi
authors.initials: L
authors.lastname: Loucif
authors.affiliation: Faculté de Médecine, Université de Batna 2, Batna, Algeria.|Laboratoire Central de Biologie Médicale, Centre Anti-Cancer, Batna, Algeria.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Kassah-Laouar
authors.affiliation: Faculté de Médecine, Université de Batna 2, Batna, Algeria.|Service Onco-Hématologie, Centre Anti-Cancer, Batna, Algeria.
authors.forename: Mahdia
authors.initials: M
authors.lastname: Saidi
authors.affiliation: Faculté de Médecine, Université de Batna 2, Batna, Algeria.
authors.forename: Amina
authors.initials: A
authors.lastname: Messala
authors.affiliation: Faculté des Sciences de la Nature et de la Vie, Université de Batna 2, Batna, Algeria.
authors.forename: Widad
authors.initials: W
authors.lastname: Chelaghma
authors.affiliation: Unité de Recherche sur les Maladies Infectieuses et Tropicales Émergentes (URMITE), UM 63, CNRS 7278, IRD 198, INSERM 1095, IHU Méditerranée Infection, Faculté de Médecine et de Pharmacie, Aix-Marseille-Université, Marseille, France jean-marc.rolain@univ-amu.fr.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Rolain
mesh_terms: D000462:Algeria / Q000453:epidemiology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016470:Bacteremia / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D002999:Clone Cells; D003227:Conjugation, Genetic; D004196:Disease Outbreaks; D000077727:Ertapenem; D015870:Gene Expression; D006785:Hospitals, University; D006801:Humans; D007710:Klebsiella Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000145:classification / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D009393:Nephritis / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D010802:Phylogeny; D010957:Plasmids / Q000737:chemistry / Q000378:metabolism; D018440:beta-Lactam Resistance / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism; D047090:beta-Lactams / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D001618:beta-Lactamases; C108449:oxacillinase; D000077727:Ertapenem