title: Association between Pesticide Use and Cholangiocarcinoma.
abstract: BACKGROUND
  Thailand remains a primarily agricultural country and Thai farmers are heavy users of pesticides. Coincidentally the incidence of cholangiocarcinoma (CCA) is high in parts of the country, but no previous study has examined any association between the two.
  
  
  METHODS
  The present matched, case-control study covered patients admitted to Srinagarind Hospital, Khon Kaen University, Thailand. The case group comprised 210 cases diagnosed with CCA and the control group 840 diagnosed with other diseases. Cases and controls were matched for sex, age within five years, and date of admission within three months. Multiple conditional logistic regression was used for the analysis.
  
  
  RESULTS
  After adjusting for potential confounders, pesticide use as compared with never used pesticide was not associated with CCA (ORadj=1.11, 95% CI: 0.77, 1.60) and neither was there any significant relationship between CCA and duration of pesticide use, type or number of types of pesticide.
  
  
  CONCLUSIONS
  The current study thus found no association between pesticide use and CCA.
authors.affiliation: Department of Epidemiology and Biostatistics, Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand E-mail : rsirip@kku.ac.th.
authors.forename: Kornthip
authors.initials: K
authors.lastname: Jeephet
authors.forename: Siriporn
authors.initials: S
authors.lastname: Kamsa-Ard
authors.forename: Vajarabhongsa
authors.initials: V
authors.lastname: Bhudhisawasdi
authors.forename: Supot
authors.initials: S
authors.lastname: Kamsa-Ard
authors.forename: Varisara
authors.initials: V
authors.lastname: Luvira
authors.forename: Vor
authors.initials: V
authors.lastname: Luvira
mesh_terms: D000383:Agriculture; D001650:Bile Duct Neoplasms / Q000209:etiology*; D016022:Case-Control Studies; D018281:Cholangiocarcinoma / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010575:Pesticides / Q000009:adverse effects*; D012307:Risk Factors; D013785:Thailand
chemical_list: D010575:Pesticides