title: Hyaluronic Acid-Coated Silver Nanoparticles As a Nanoplatform for in Vivo Imaging Applications.
abstract: An efficient chemical reduction protocol has been developed for the synthesis of hyaluronic acid-coated silver nanoparticles (HA-Ag NPs) that are spherical, ultrasmall and monodisperse. The as-synthesized HA-Ag NPs not only exhibited excellent long-term stability and low cytotoxicity but also could be used as a nanoplatform for X-ray computed tomography (CT) and single-photon emission computed tomography (SPECT) imaging after being radiolabeled with99mTc.
authors.affiliation: Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center , Beijing 100191, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center , Beijing 100191, China.
authors.forename: Meinan
authors.initials: M
authors.lastname: Yao
authors.affiliation: Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center , Beijing 100191, China.
authors.forename: Muhua
authors.initials: M
authors.lastname: Chen
authors.affiliation: Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center , Beijing 100191, China.
authors.forename: Liqiang
authors.initials: L
authors.lastname: Li
authors.affiliation: Key Laboratory of Protein and Peptide Pharmaceuticals, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences , Beijing 100101, China.
authors.forename: Chengyan
authors.initials: C
authors.lastname: Dong
authors.affiliation: Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Hou
authors.affiliation: Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center , Beijing 100191, China.|Medical and Healthy Analytical Center, Peking University , Beijing 100191, China.
authors.forename: Huiyun
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center , Beijing 100191, China.|Medical and Healthy Analytical Center, Peking University , Beijing 100191, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Jia
authors.affiliation: Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center , Beijing 100191, China.|Key Laboratory of Protein and Peptide Pharmaceuticals, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences , Beijing 100101, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Wang
mesh_terms: D006820:Hyaluronic Acid; D053768:Metal Nanoparticles; D012834:Silver; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D012834:Silver; D006820:Hyaluronic Acid
keywords: HA-Ag NPs; SPECT imaging; X-ray computed tomography (CT); long-term stability; low cytotoxicity; nanoplatform