title: Reduction of the Lamina Cribrosa Curvature After Trabeculectomy in Glaucoma.
abstract: OBJECTIVE
  To investigate whether the lamina cribrosa (LC) curvature is decreased after trabeculectomy.
  
  
  METHODS
  Thirty-nine eyes of 39 patients with primary open-angle glaucoma who underwent trabeculectomy were included. Optic nerves were scanned by using enhanced-depth-imaging spectral-domain optical coherence tomography before and after trabeculectomy. The LC curvature was assessed by measuring the LC curvature index (LCCI) in seven horizontal B-scan images in each eye.
  
  
  RESULTS
  The LCCI was significantly smaller at postoperative 6 months than at the preoperative level in all seven planes (all P < 0.001). Preoperative LCCI was associated with younger age at superior midperiphery, midhorizontal plane, inferior midperiphery (all P ≤ 0.005) and higher preoperative intraocular pressure (IOP) at superior and inferior midperiphery (both P = 0.039). Younger age and larger preoperative LCCI were associated with a larger reduction of the LCCI at all three locations (P = 0.003 and 0.031 at superior midperiphery, P = 0.011 and 0.001 at midhorizontal plane, and P = 0.014 and 0.005 at inferior midperiphery, respectively), whereas the percentage IOP lowering was associated at superior and inferior midperiphery (P = 0.017 and 0.047, respectively).
  
  
  CONCLUSIONS
  Lamina cribrosa curvature was reduced after trabeculectomy. This finding suggests that LC curvature may have value as a parameter relevant to optic nerve head biomechanics.
authors.affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
authors.forename: Seung Hyen
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Da-Ae
authors.initials: DA
authors.lastname: Yu
authors.affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
authors.forename: Tae-Woo
authors.initials: TW
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
authors.forename: Eun Ji
authors.initials: EJ
authors.lastname: Lee
authors.affiliation: Department of Biomedical Engineering, National University of Singapore, Singapore 4Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
authors.forename: Michaël J A
authors.initials: MJ
authors.lastname: Girard
authors.affiliation: GePaSud, Université de la Polynésie Française, Tahiti, French Polynesia.
authors.forename: Jean Martial
authors.initials: JM
authors.lastname: Mari