title: Identification of 5-hydroxytryptamine receptor gene polymorphisms modulating hyperprolactinaemia in antipsychotic drug-treated patients with schizophrenia.
abstract: Hyperprolactinaemia (HPRL) is a classical side effect of antipsychotic drugs primarily attributed to blockade of dopamine D2 subtype receptors in the pituitary gland. Although dopamine is considered the primary factor inhibiting prolactin release, the activity of prolactin-producing lactotrophs is also regulated by the secretagogues thyrotrophin releasing hormone, vasoactive intestinal polypeptide and serotonin (5-hydroxytryptamine; 5-HT).
  
  
  
  We describe the association between HPRL and a set of 29 SNPs from 5-HT receptor genes HTR1A, HTR1B, HTR2A, HTR2C, HTR3A, HTR3B and HTR6 in a population of 446 Caucasians (221 males/225 females) with a clinical diagnosis of schizophrenia (according to ICD-10: F20) who were treated with classical and/or atypical antipsychotic drugs.
  
  
  
  None of the studied autosomal markers were found to be associated with HPRL. However, a significant association was established between various HTR2C polymorphisms and HPRL.
  
  
  
  This study revealed an association between HPRL and X-chromosome haplotypes comprised of the rs569959 and rs17326429 polymorphisms.
authors.affiliation: a Mental Health Research Institute , Tomsk , Russian Federation.|b National Research Tomsk Polytechnic University , Tomsk , Russian Federation.
authors.forename: Svetlana A
authors.initials: SA
authors.lastname: Ivanova
authors.affiliation: a Mental Health Research Institute , Tomsk , Russian Federation.|c National Research Tomsk State University , Tomsk , Russian Federation.
authors.forename: Diana Z
authors.initials: DZ
authors.lastname: Osmanova
authors.affiliation: d Department of Twin Research and Genetic Epidemiology , King's College London , London , UK.|e Research Institute for Medical Genetics , Tomsk , Russian Federation.
authors.forename: Maxim B
authors.initials: MB
authors.lastname: Freidin
authors.affiliation: a Mental Health Research Institute , Tomsk , Russian Federation.|b National Research Tomsk Polytechnic University , Tomsk , Russian Federation.
authors.forename: Olga Yu
authors.initials: OY
authors.lastname: Fedorenko
authors.affiliation: a Mental Health Research Institute , Tomsk , Russian Federation.
authors.forename: Anastasia S
authors.initials: AS
authors.lastname: Boiko
authors.affiliation: a Mental Health Research Institute , Tomsk , Russian Federation.|c National Research Tomsk State University , Tomsk , Russian Federation.
authors.forename: Ivan V
authors.initials: IV
authors.lastname: Pozhidaev
authors.affiliation: a Mental Health Research Institute , Tomsk , Russian Federation.
authors.forename: Arkadiy V
authors.initials: AV
authors.lastname: Semke
authors.affiliation: a Mental Health Research Institute , Tomsk , Russian Federation.|c National Research Tomsk State University , Tomsk , Russian Federation.
authors.forename: Nikolay A
authors.initials: NA
authors.lastname: Bokhan
authors.affiliation: a Mental Health Research Institute , Tomsk , Russian Federation.
authors.forename: Alexey A
authors.initials: AA
authors.lastname: Agarkov
authors.affiliation: f Department of Pharmacy , University of Groningen , Groningen , The Netherlands.|g Department of Clinical Pharmacy and Pharmacology , University of Groningen, University Medical Center Groningen , Groningen , The Netherlands.
authors.forename: Bob
authors.initials: B
authors.lastname: Wilffert
authors.affiliation: g Department of Clinical Pharmacy and Pharmacology , University of Groningen, University Medical Center Groningen , Groningen , The Netherlands.|h GGZ Westelijk Noord-Brabant , Bergen op Zoom , The Netherlands.
authors.forename: Anton J M
authors.initials: AJ
authors.lastname: Loonen
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D041321:Chromosomes, Human, X; D004298:Dopamine / Q000378:metabolism; D005260:Female; D006239:Haplotypes; D006801:Humans; D006966:Hyperprolactinemia / Q000139:chemically induced / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000187:drug effects*; D020641:Polymorphism, Single Nucleotide; D044405:Receptor, Serotonin, 5-HT2C / Q000235:genetics*; D012559:Schizophrenia / Q000188:drug therapy*; D012800:Siberia
chemical_list: D014150:Antipsychotic Agents; D044405:Receptor, Serotonin, 5-HT2C; D004298:Dopamine
keywords: Serotonin receptors; antipsychotics; hyperprolactinaemia; polymorphism; schizophrenia