title: Pregnancy-driven cardiovascular maternal miR-29 plasticity in obesity.
abstract: Obesity in pregnancy (MO) is a risk factor for maternal and/or fetal cardiovascular system disorders. This study evaluated maternal CVS expression of microRNA-29 family and its target molecules in MO to test the hypotheses: CVS miR-29 concentrations are increased in pregnancy and decreased in MO.
  
  
  
  Non-pregnant (n=4), pregnant obese (POb, n=4), and pregnant non-obese (PnOb, n=4) baboons (Papio spp.) were studied. Maternal left ventricle (LV), left atrium (LA), and aortic arch (AA) were collected at the end of gestation. Expression of MiR-29 and elastin (ELN) mRNA were quantified.
  
  
  
  LA miR-29 (a, c) expression was highest in PnOb. In the LV, miR-29b expression trended lower (P=.059) for PnOb animals. ELN mRNA expression correlated positively with miR-29b expression in AA (r=.76, P=.03).
  
  
  
  Maternal obesity diminishes miR-29 adaptation to pregnancy. Pharmacologic, tissue-specific targeting of miRNA-29 may represent a strategy for prevention and treatment of MO complications.
authors.affiliation: Department of Obstetrics and Gynecology, Texas Tech University Health Sciences Center at the Permian Basin, Odessa, TX, USA.
authors.forename: N
authors.initials: N
authors.lastname: Schlabritz-Loutsevitch
authors.affiliation: Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, TN, USA.
authors.forename: K
authors.initials: K
authors.lastname: Apostolakis-Kyrus
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
authors.forename: R
authors.initials: R
authors.lastname: Krutilina
authors.affiliation: Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
authors.forename: G
authors.initials: G
authors.lastname: Hubbard
authors.affiliation: Division of Biostatistics and Epidemiology, Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
authors.forename: M
authors.initials: M
authors.lastname: Kocak
authors.affiliation: Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA.
authors.forename: Z
authors.initials: Z
authors.lastname: Janjetovic
authors.affiliation: Division of Pediatric Cardiology, University of Tennessee Health Science Center, Memphis, TN, USA.
authors.forename: S
authors.initials: S
authors.lastname: Sathanandam
authors.affiliation: Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA.|VA Medical Center, Birmingham AL, USA.
authors.forename: A T
authors.initials: AT
authors.lastname: Slominski
authors.affiliation: Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, TN, USA.
authors.forename: G
authors.initials: G
authors.lastname: Mari
authors.affiliation: Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
authors.forename: E
authors.initials: E
authors.lastname: Dick
mesh_terms: D000818:Animals; D005260:Female; D035683:MicroRNAs / Q000378:metabolism*; D008992:Monkey Diseases / Q000209:etiology / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D009765:Obesity / Q000209:etiology / Q000378:metabolism / Q000662:veterinary*; D010215:Papio; D011247:Pregnancy
chemical_list: D035683:MicroRNAs
keywords: maternal obesity; non-human primate; vascular remodeling