title: Anthocyanin Attenuates Doxorubicin-Induced Cardiomyotoxicity via Estrogen Receptor-α/β and Stabilizes HSF1 to Inhibit the IGF-IIR Apoptotic Pathway.
abstract: Doxorubicin (Dox) is extensively used for chemotherapy in different types of cancer, but its use is limited to because of its cardiotoxicity. Our previous studies found that doxorubicin-induced insulin-like growth factor II receptor (IGF-IIR) accumulation causes cardiomyocytes apoptosis via down-regulation of HSF1 pathway. In these studies, we demonstrated a new mechanism through which anthocyanin protects cardiomyoblast cells against doxorubicin-induced injury. We found that anthocyanin decreased IGF-IIR expression via estrogen receptors and stabilized heat shock factor 1 (HSF1) to inhibit caspase 3 activation and apoptosis of cardiomyocytes. Therefore, the phytoestrogen from plants has been considered as another potential treatment for heart failure. It has been reported that the natural compound anthocyanin (ACN) has the ability to reduce the risk of cardiovascular disease (CVD). Here, we demonstrated that anthocyanin acts as a cardioprotective drug against doxorubicin-induced heart failure by attenuating cardiac apoptosis via estrogen receptors to stabilize HSF1 expression and down-regulated IGF-IIR-induced cardiomyocyte apoptosis.
authors.affiliation: Graduate Institute of Clinical Medical Science, China Medical University, Taichung 40402, Taiwan. d27333@mail.cmuh.org.tw.|Department of Obstetrics and Gynecology, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan. d27333@mail.cmuh.org.tw.
authors.forename: Pei-Chen
authors.initials: PC
authors.lastname: Huang
authors.affiliation: Department of Biological Science and Technology, China Medical University, Taichung 40402, Taiwan. wwkuo@mail.cmu.edu.tw.
authors.forename: Wei-Wen
authors.initials: WW
authors.lastname: Kuo
authors.affiliation: Department of Nursing, Mei Ho University, Pingguang Road, Pingtung 91202, Taiwan. x00003061@email.meiho.edu.tw.
authors.forename: Chia-Yao
authors.initials: CY
authors.lastname: Shen
authors.affiliation: Section of Cardiology, Yuan Rung Hospital, Yuanlin 51045, Taiwan. ab8142002@yahoo.com.tw.
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Chen
authors.affiliation: Department of Pathology, Changhua Christian Hospital, Changhua 500, Taiwan. 93668@cch.org.tw.|Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli 35664, Taiwan. 93668@cch.org.tw.
authors.forename: Yueh-Min
authors.initials: YM
authors.lastname: Lin
authors.affiliation: Chinese Medicine Department, China Medical University Beigang Hospital, Taichung 40402, Taiwan. jeron888@gmail.com.
authors.forename: Tsung-Jung
authors.initials: TJ
authors.lastname: Ho
authors.affiliation: Department of Biotechnology, Bharathiar University, Coimbatore 641046, India. padma.vijaya@gmail.com.
authors.forename: V Vijaya
authors.initials: VV
authors.lastname: Padma
authors.affiliation: Institute of Oral Biology, National Yang-Ming University, Taipei 11221, Taiwan. jflo@ym.edu.tw.
authors.forename: Jeng-Fan
authors.initials: JF
authors.lastname: Lo
authors.affiliation: Translation Research Core, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan. terp3458@yahoo.com.tw.
authors.forename: Chih-Yang
authors.initials: CY
authors.lastname: Huang
authors.affiliation: Graduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan. cyhuang@mail.cmu.edu.tw.|Graduate Institute of Chinese Medical Science, China Medical University, Hsueh-Shih Road, Taichung 40402, Taiwan. cyhuang@mail.cmu.edu.tw.|Department of Health and Nutrition Biotechnology, Asia University, Taichung 40402, Taiwan. cyhuang@mail.cmu.edu.tw.
authors.forename: Chih-Yang
authors.initials: CY
authors.lastname: Huang
keywords: IGF-IIR signaling; anthocyanin; apoptosis; cardiomyocyte; doxorubicin; estrogen receptors