title: Soluble (Pro) Renin Receptor is a Predictor of Gestational Diabetes Mellitus.
abstract: BACKGROUND
  Gestational diabetes mellitus (GDM) is a common endocrine complication in pregnancy. While it has been established that age, family history of diabetes, insulin resistance and several biomarkers are associated with GDM but significant gaps remain in understanding risk factors for GDM. Soluble pro-renin receptor (s [Pro] RR) as a biomarker reflects the activation of renin-angiotensin system in tissues which may be related to insulin resistance Objective: The aim of this study was to determine the role of (s [pro] RR) in predicting GDM.
  
  
  METHODS
  one hundred-eighty singleton pregnant women in first trimester were enrolled. We excluded women with previous history of GDM, hypertension and consumption of drugs affected reninangiotensin system. A fasting blood glucose and s (pro) RR level were obtained during first trimester and OGTT was performed at 24-28 weeks of gestation. We used ROC curves to identify s (pro) RR cutoff points for detecting GDM and the difference in s (pro)RR level was assessed in GDM and non- GDM women.
  
  
  RESULTS
  Among 180 women, 24 (13.33%) had GDM. There was no significant difference between age and body mass index in subjects with GDM compared to non- GDM. The concentration of s (pro) RR was significantly higher in GDM subjects rather than non- GDM [29.27(24.60-35.92) vs. 22.89(19.46- 24.27), P<0.001]. Multiple logistic regression analysis revealed a significant association of s(pro) RR with GDM (odd ratio: 1.32, 95% CI: 1.17-1.48, P=0.04). A cut-off point 24.52 ng/ml of s(pro) RR had 75% sensitivity and 80% specificity for predicting GDM.
  
  
  CONCLUSIONS
  Increased level of s (pro) RR in first trimester may be a marker for predicting GDM.
authors.affiliation: Endocrine Research Center, Faculty of Medicine, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Postal Code: 91766. Iran.
authors.forename: Shokoufeh
authors.initials: S
authors.lastname: Bonakdaran
authors.affiliation: Endocrine Research Center, Mashhad University of Medical Sciences, Mashhad. Iran.
authors.forename: Ghazaleh
authors.initials: G
authors.lastname: Azami
authors.affiliation: Department of Obstetrics and Gynecology, Ommolbanin Hospital, Mashhad University of Medical Sciences, Mashhad. Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Tara
authors.affiliation: Department of Obstetrics and Gynecology, Ommolbanin Hospital, Mashhad University of Medical Sciences, Mashhad. Iran.
authors.forename: Leila
authors.initials: L
authors.lastname: Poorali
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016640:Diabetes, Gestational / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance; D007492:Iran; D016015:Logistic Models; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood* / Q000175:diagnosis*; D011261:Pregnancy Trimester, First; D012372:ROC Curve; D011956:Receptors, Cell Surface / Q000097:blood*; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012995:Solubility; D025262:Vacuolar Proton-Translocating ATPases / Q000097:blood*; D055815:Young Adult; D000093342:Prorenin Receptor
chemical_list: D015415:Biomarkers; D011956:Receptors, Cell Surface; D025262:Vacuolar Proton-Translocating ATPases; C458319:ATP6AP2 protein, human; D000093342:Prorenin Receptor
keywords: Biomarkers; Gestational Diabetes Mellitus (GDM); glucose; insulin resistance; pregnancy; soluble pro-renin receptor