title: Inflammation at the blood-brain barrier: The role of liver X receptors.
abstract: The blood-brain barrier (BBB) is indispensable for the maintenance of brain homeostasis and proper neuronal functioning. Dysfunction of the BBB significantly contributes to the pathogenesis of neuroinflammatory and neurodegenerative diseases like stroke, multiple sclerosis (MS), and Alzheimer's disease (AD). The neuroinflammatory environment that characterizes these disorders propagates chronic impaired function of the BBB, processes that will be discussed in this review. Limiting dysfunction of the BBB may be an attractive target for treatment of neurological disorders. To date, no current treatments are directly targeting the function of the BBB. In this review, we will specifically discuss the potential protective role of nuclear liver X receptors (LXRs) as a promising therapeutic target to reverse or prevent BBB impairment in neurological diseases.
authors.affiliation: Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: n.dewit1@vumc.nl.
authors.forename: N M
authors.initials: NM
authors.lastname: de Wit
authors.affiliation: Biomedical Research Institute, School of Life Sciences, Hasselt University/Transnational University Limburg, Diepenbeek, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Vanmol
authors.affiliation: Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Kamermans
authors.affiliation: Biomedical Research Institute, School of Life Sciences, Hasselt University/Transnational University Limburg, Diepenbeek, Belgium.
authors.forename: Jja
authors.initials: J
authors.lastname: Hendriks
authors.affiliation: Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: H E
authors.initials: HE
authors.lastname: de Vries
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000276:immunology*; D006801:Humans; D000071518:Liver X Receptors / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000378:metabolism; D015213:Neuroimmunomodulation / Q000502:physiology; D000066829:Neuroprotection / Q000502:physiology
chemical_list: D000071518:Liver X Receptors
keywords: Blood-brain barrier; Liver X receptor; Neurodegenerative disease; Neuroinflammation; Tight junction