title: Rapid Photoactivated Generation of Nitroxyl (HNO) under Neutral pH Conditions.
abstract: Directly obtaining kinetic and mechanistic data for the reactions of nitroxyl (HNO) with biomolecules (k≈103-107m-1s-1) is not feasible for many systems because of slow HNO release from HNO donor molecules (t1/2is typically minutes to hours). To address this limitation, we have developed a photoactivatable HNO donor incorporating the (3-hydroxy-2-naphthalenyl)methyl phototrigger, which rapidly releases HNO on demand. A "proof of concept" study is reported, which demonstrates that, upon continuous xenon light excitation, rapid decomposition of the HNO donor occurs within seconds. The amount of HNO generated is strongly dependent on solvent and the rate of the reaction is dependent on the light intensity.
authors.affiliation: Department of Chemistry and Biochemistry, Kent State University (KSU), Kent, OH, 44240, USA.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: School of Applied Sciences, Auckland University of Technology (AUT), Private Bag 92006, Auckland, 1142, New Zealand.
authors.forename: Ruth B
authors.initials: RB
authors.lastname: Cink
authors.affiliation: Department of Chemistry and Biochemistry, Kent State University (KSU), Kent, OH, 44240, USA.
authors.forename: Rohan S
authors.initials: RS
authors.lastname: Dassanayake
authors.affiliation: Department of Chemistry and Biochemistry, Kent State University (KSU), Kent, OH, 44240, USA.
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Seed
authors.affiliation: School of Applied Sciences, Auckland University of Technology (AUT), Private Bag 92006, Auckland, 1142, New Zealand. nbrasch@aut.ac.nz.
authors.forename: Nicola E
authors.initials: NE
authors.lastname: Brasch
authors.affiliation: Department of Chemistry and Biochemistry, Kent State University (KSU), Kent, OH, 44240, USA. psampson@kent.edu.
authors.forename: Paul
authors.identifier: 0000-0002-0135-3161
authors.initials: P
authors.lastname: Sampson
keywords: HNO donors; nitrosyl hydride; nitroxyl; photochemistry; photolysis