title: Loss of Lysyl Oxidase-like 3 Attenuates Embryonic Lung Development in Mice.
abstract: Lysyl oxidase-like 3 (LOXL3), a human disease gene candidate, is a member of the lysyl oxidase (LOX) family and is indispensable for mouse palatogenesis and vertebral column development. Our previous study showed that the loss of LOXL3 resulted in a severe cleft palate and spinal deformity. In this study, we investigated a possible role for LOXL3 in mouse embryonic lung development. LOXL3-deficient mice displayed reduced lung volumes and weights, diminished saccular spaces, and deformed and smaller thoracic cavities. Excess elastic fibres were detected in LOXL3-deficient lungs, which might be related to the increased LOXL4 expression. Increased transforming growth factor β1 (TGFβ1) expression might be involved in the up-regulation of LOXL4 in LOXL3-deficient lungs. We concluded that the loss of LOXL3 attenuates mouse embryonic lung development.
authors.affiliation: School of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan 250100, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: School of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan 250100, China.
authors.forename: Ziyi
authors.initials: Z
authors.lastname: Liu
authors.affiliation: School of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan 250100, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Jinan First People's Hospital, Jinan 250011, China.
authors.forename: Zhuchun
authors.initials: Z
authors.lastname: Lin
authors.affiliation: School of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan 250100, China.
authors.forename: Zhenzu
authors.initials: Z
authors.lastname: Li
authors.affiliation: School of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan 250100, China.
authors.forename: Aizhen
authors.initials: A
authors.lastname: Zhang
authors.affiliation: School of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan 250100, China.
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Sun
authors.affiliation: School of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan 250100, China.
authors.forename: Jiangang
authors.initials: J
authors.lastname: Gao
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000172:deficiency*; D000818:Animals; D004622:Embryo, Mammalian / Q000196:embryology*; D018507:Gene Expression Regulation, Developmental; D008168:Lung / Q000196:embryology*; D051379:Mice; D018345:Mice, Knockout; D038081:Organogenesis; D008249:Protein-Lysine 6-Oxidase / Q000096:biosynthesis / Q000235:genetics; D053773:Transforming Growth Factor beta1 / Q000096:biosynthesis / Q000235:genetics
chemical_list: C508961:Tgfb1 protein, mouse; D053773:Transforming Growth Factor beta1; D000594:Amino Acid Oxidoreductases; C511777:LOXL3 protein, mouse; C432408:Loxl4 protein, mouse; D008249:Protein-Lysine 6-Oxidase