title: Immunopathology alters Th17 cell glucocorticoid sensitivity.
abstract: Th17 cells contribute to several inflammatory conditions and increasing evidence supports that Th17 cells are glucocorticoid resistant. However, Th17 cells in psoriasis and related diseases are glucocorticoid sensitive. We compare glucocorticoid sensitive and resistant immunological diseases and suggest that several aspects in Th17-related diseases alter glucocorticoid sensitivity of Th17 cells. We identify molecular pathways that are implicated in glucocorticoid sensitivity of Th17 cells in the literature, as this information is useful for developing approaches to overcome glucocorticoid-resistant immunopathology.
authors.affiliation: Division of Allergy-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: J
authors.initials: J
authors.lastname: Banuelos
authors.affiliation: Division of Allergy-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Division of Allergy-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: S C
authors.initials: SC
authors.lastname: Shin
authors.affiliation: Division of Allergy-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: N Z
authors.initials: NZ
authors.lastname: Lu
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism / Q000494:pharmacology*; D002454:Cell Differentiation / Q000276:immunology; D016207:Cytokines / Q000378:metabolism; D004198:Disease Susceptibility; D004361:Drug Tolerance; D005786:Gene Expression Regulation; D005938:Glucocorticoids / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007154:Immune System Diseases / Q000188:drug therapy / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D007249:Inflammation / Q000188:drug therapy / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D058504:Th17 Cells / Q000166:cytology / Q000187:drug effects* / Q000276:immunology* / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D005938:Glucocorticoids
keywords: Th17 cells; asthma; autoimmunity; glucocorticoid resistance; glucocorticoids