title: Overhydration Negatively Affects Quality of Life in Peritoneal Dialysis Patients: Evidence from a Prospective Observational Study.
abstract: Backgound: This study evaluated whether the hydration status affected health-related quality of life (HRQOL) during 12 months in peritoneal dialysis (PD) patients.
  
  
  METHODS
  The hydration status and the HRQOL were examined at baseline and after 12 months using a bioimpedance spectroscopy and Kidney Disease Quality of Life-Short Form, respectively in PD patients. Four hundred eighty-one patients were included and divided according to the baseline overhydration (OH) value; normohydration group (NH group, -2L≤ OH ≤+2L, n=266) and overhydration group (OH group, OH >+2L, n=215). Baseline HRQOL scores were compared between the two groups. The subjects were re-stratified into quartiles according to the OH difference (OH value at baseline - OH value at 12 months; <-1, -1 - -0.1, -0.1 - +1, and ≥+1L). The relations of OH difference with HRQOL scores at 12 months and the association of OH difference with the HRQOL score difference (HRQOL score at baseline - HRQOL score at 12 months) were assessed.
  
  
  RESULTS
  The OH group showed significantly lower baseline physical and mental health scores (PCS and MCS), and kidney disease component scores (KDCS) compared with the NH group (all, P<0.01). At 12 months, the adjusted PCS, MCS, and KDCS significantly increased as the OH difference quartiles increased (P<0.001, P=0.002, P<0.001, respectively). In multivariate analysis, the OH difference was independently associated with higher PCS (β = 2.04, P< .001), MCS (β=1.02, P=0.002), and KDCS (β=1.06, P<0.001) at 12 months. The OH difference was independently associated with the PCS difference (β = -1.81, P<0.001), MCS difference (β=-0.92, P=0.01), and KDCS difference (β=-0.90, P=0.001).
  
  
  CONCLUSIONS
  The hydration status was associated with HRQOL and increased hydration status negatively affected HRQOL after 12 months in PD patients.
authors.affiliation: Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea.
authors.forename: Hye Eun
authors.initials: HE
authors.lastname: Yoon
authors.affiliation: Department of Internal Medicine, Guro Hospital, Korea University;
authors.forename: Young Joo
authors.initials: YJ
authors.lastname: Kwon
authors.affiliation: Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea.
authors.forename: Ho Cheol
authors.initials: HC
authors.lastname: Song
authors.affiliation: Department of Internal Medicine, Soonchunhyang University Bucheon Hospital;
authors.forename: Jin Kuk
authors.initials: JK
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Hallym University Sacred Heart Hospital;
authors.forename: Young Rim
authors.initials: YR
authors.lastname: Song
authors.affiliation: Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea.
authors.forename: Seok Joon
authors.initials: SJ
authors.lastname: Shin
authors.affiliation: Department of Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea.
authors.forename: Hyung Wook
authors.initials: HW
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Hanyang University Medical Center;
authors.forename: Chang Hwa
authors.initials: CH
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, KyungHee University Medical Center;
authors.forename: Tae Won
authors.initials: TW
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea.
authors.forename: Young Ok
authors.initials: YO
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, St. Paul's Hospital, The Catholic University of Korea.
authors.forename: Byung Soo
authors.initials: BS
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Veterans Health Service Medical Center;
authors.forename: Kyoung Hyoub
authors.initials: KH
authors.lastname: Moon
authors.affiliation: Department of Internal Medicine, Daejeon St. Mary's Hospital, The Catholic University of Korea.
authors.forename: Yoon Kyung
authors.initials: YK
authors.lastname: Chang
authors.affiliation: Department of Internal Medicine, Daejeon Sun Hospital;
authors.forename: Seong Suk
authors.initials: SS
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Eulji University Hospital;
authors.forename: Kitae
authors.initials: K
authors.lastname: Bang
authors.affiliation: Department of Internal Medicine, Dankook University Hospital;
authors.forename: Jong Tae
authors.initials: JT
authors.lastname: Cho
authors.affiliation: Department of Internal Medicine, Konyang University Hospital;
authors.forename: Sung Ro
authors.initials: SR
authors.lastname: Yun
authors.affiliation: Department of Internal Medicine, Chungnam National University Hospital;
authors.forename: Ki Ryang
authors.initials: KR
authors.lastname: Na
authors.affiliation: Department of Internal Medicine, Inje University Haeundae Paik Hospital;
authors.forename: Yang Wook
authors.initials: YW
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Yonsei University Wonju College of Medicine;
authors.forename: Byoung Geun
authors.initials: BG
authors.lastname: Han
authors.affiliation: Department of Internal Medicine, Chosun University Hospital;
authors.forename: Jong Hoon
authors.initials: JH
authors.lastname: Chung
authors.affiliation: Department of Internal Medicine, Presbyterian Medical Center.
authors.forename: Kwang Young
authors.initials: KY
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, St. Carollo Hospital;
authors.forename: Jong Hyeok
authors.initials: JH
authors.lastname: Jeong
authors.affiliation: Department of Internal Medicine, Keimyung University Dongsan Medical Center;
authors.forename: Eun Ah
authors.initials: EA
authors.lastname: Hwang
authors.affiliation: Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Yong-Soo
authors.initials: YS
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D003681:Dehydration / Q000150:complications / Q000503:physiopathology*; D058266:Dielectric Spectroscopy; D005260:Female; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D007674:Kidney Diseases / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D011788:Quality of Life; D059289:Vascular Stiffness / Q000502:physiology
keywords: bioimpedance; fluid overload; overhydration; peritoneal dialysis; quality of life.