title: Quantifying tissue viscoelasticity using optical coherence elastography and the Rayleigh wave model.
abstract: This study demonstrates the feasibility of using the Rayleigh wave model (RWM) in combination with optical coherence elastography (OCE) technique to assess the viscoelasticity of soft tissues. Dispersion curves calculated from the spectral decomposition of OCE-measured air-pulse induced elastic waves were used to quantify the viscoelasticity of samples using the RWM. Validation studies were first conducted on 10% gelatin phantoms with different concentrations of oil. The results showed that the oil increased the viscosity of the gelatin phantom samples. This method was then used to quantify the viscoelasticity of chicken liver. The Young’s modulus of the chicken liver tissues was estimated as E=2.04±0.88??kPa with a shear viscosity ?=1.20±0.13??Pa?s. The analytical solution of the RWM correlated very well with the OCE-measured phased velocities (R2=0.96±0.04). The results show that the combination of the RWM and OCE is a promising method for noninvasively quantifying the biomechanical properties of soft tissues and may be a useful tool for detecting disease.
authors.affiliation: University of Houston, Department of Biomedical Engineering, 3605 Cullen Boulevard, Houston, Texas 77204, United States.
authors.forename: Zhaolong
authors.initials: Z
authors.lastname: Han
authors.affiliation: University of Houston, Department of Biomedical Engineering, 3605 Cullen Boulevard, Houston, Texas 77204, United States.
authors.forename: Manmohan
authors.initials: M
authors.lastname: Singh
authors.affiliation: University of Texas at Austin, Department of Biomedical Engineering, 107 West Dean Keeton Street, Stop C0800, Austin, Texas 78712, United States.
authors.forename: Salavat R
authors.initials: SR
authors.lastname: Aglyamov
authors.affiliation: University of Houston, Department of Biomedical Engineering, 3605 Cullen Boulevard, Houston, Texas 77204, United States.
authors.forename: Chih-Hao
authors.initials: CH
authors.lastname: Liu
authors.affiliation: University of Houston, Department of Biomedical Engineering, 3605 Cullen Boulevard, Houston, Texas 77204, United States.
authors.forename: Achuth
authors.initials: A
authors.lastname: Nair
authors.affiliation: University of Houston, Department of Biomedical Engineering, 3605 Cullen Boulevard, Houston, Texas 77204, United States.
authors.forename: Raksha
authors.initials: R
authors.lastname: Raghunathan
authors.affiliation: University of Houston, Department of Biomedical Engineering, 3605 Cullen Boulevard, Houston, Texas 77204, United States.
authors.forename: Chen
authors.initials: C
authors.lastname: Wu
authors.affiliation: University of Houston, Department of Biomedical Engineering, 3605 Cullen Boulevard, Houston, Texas 77204, United States.
authors.forename: Jiasong
authors.initials: J
authors.lastname: Li
authors.affiliation: University of Houston, Department of Biomedical Engineering, 3605 Cullen Boulevard, Houston, Texas 77204, United StatescTomsk State University, Interdisciplinary Laboratory of Biophotonics, 36 Lenin Avenue, Tomsk 634050, RussiadBaylor College of Medicine, Molecular Physiology and Biophysics, One Baylor Plaza, Houston, Texas 77030, United States.
authors.forename: Kirill V
authors.initials: KV
authors.lastname: Larin