title: Antiretroviral therapy in HIV-infected children.
abstract: The pediatric highly-active antiretroviral therapy (HAART) has shown enormous progress in recent years but still, a high percentage of children continue to experience treatment failure. The main causes found responsible are the development of drug resistance, inadequate dosing and poor adherence. This review is aimed at exploring the current status of antiretroviral therapy in children with focus on the interaction between disease, drug and patient behavior, all of which are strongly correlated .An overview of HIV viral characteristics and of the available antiretroviral drug classes currently combined to avoid development of resistance has been also discussed.
authors.affiliation: Department of Anesthesiology, Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou, China.
authors.forename: Conghai
authors.initials: C
authors.lastname: Fan
authors.affiliation: Department of Anesthesiology, Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou, China - fengchaozhang007@gmail.com.
authors.forename: Fengchao
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology, Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000494:pharmacology; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D002648:Child; D004305:Dose-Response Relationship, Drug; D024882:Drug Resistance, Viral; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D055118:Medication Adherence; D017211:Treatment Failure
chemical_list: D019380:Anti-HIV Agents