title: Facilitators of HCV treatment adherence among people who inject drugs: a systematic qualitative review and implications for scale up of direct acting antivirals.
abstract: While the public health benefits of new HCV treatments depend on treatment adherence, particularly among people who inject drugs (PWID), several social and medical factors can jeopardize treatment adherence. The aim of this study is to examine the qualitative literature on facilitators to HCV treatment adherence among PWID.
  
  
  
  We searched six databases to identify qualitative research studies on HCV treatment adherence facilitators among PWID. Two reviewers independently extracted and analyzed data using PRISMA guidelines and the CASP tool to evaluate study quality.
  
  
  
  From ten studies representing data from 525 participants, three major themes emerged across studies: logistical facilitators within health systems enhanced HCV treatment adherence, positive social interactions between PWID and staff provided positive feedback during treatment, and HCV treatment may complicate the addiction recovery process.
  
  
  
  Although PWID face several barriers to adherence, we identified treatment adherence facilitators that could be incorporated into clinical practice.
authors.affiliation: UNC Project China, Guangdong Provincial Dermatovenerology Hospital, Guangdong Province, 2 Lujing Road, Floor 11, Guangzhou, 510095, Guangdong, China.
authors.forename: Zachary C
authors.initials: ZC
authors.lastname: Rich
authors.affiliation: UNC Project China, Guangdong Provincial Dermatovenerology Hospital, Guangdong Province, 2 Lujing Road, Floor 11, Guangzhou, 510095, Guangdong, China.|Department of Medicine, School of Medicine, University of California San Francisco, San Francisco, 94143, California, USA.
authors.forename: Carissa
authors.initials: C
authors.lastname: Chu
authors.affiliation: UNC Project China, Guangdong Provincial Dermatovenerology Hospital, Guangdong Province, 2 Lujing Road, Floor 11, Guangzhou, 510095, Guangdong, China.
authors.forename: Jessica
authors.initials: J
authors.lastname: Mao
authors.affiliation: UNC Project China, Guangdong Provincial Dermatovenerology Hospital, Guangdong Province, 2 Lujing Road, Floor 11, Guangzhou, 510095, Guangdong, China.
authors.forename: Kali
authors.initials: K
authors.lastname: Zhou
authors.affiliation: Guangzhou Number Eight People's Hospital, Guangzhou, 510000, China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Cai
authors.affiliation: UNC Project China, Guangdong Provincial Dermatovenerology Hospital, Guangdong Province, 2 Lujing Road, Floor 11, Guangzhou, 510095, Guangdong, China.
authors.forename: Qingyan
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Department of Medicine, School of Medicine, University of California San Francisco, San Francisco, 94143, California, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Volberding
authors.affiliation: UNC Project China, Guangdong Provincial Dermatovenerology Hospital, Guangdong Province, 2 Lujing Road, Floor 11, Guangzhou, 510095, Guangdong, China. jdtucker@med.unc.edu.|Institute of Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, 27517, North Carolina, USA. jdtucker@med.unc.edu.
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Tucker
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D016208:Databases, Factual; D006526:Hepatitis C / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D010349:Patient Compliance; D012932:Social Facilitation; D015819:Substance Abuse, Intravenous / Q000150:complications*
chemical_list: D000998:Antiviral Agents
keywords: Hepatitis C virus; Injection drug use; Treatment adherence