title: Added Value of IP-10 as a Read-Out of Mycobacterium tuberculosis: Specific Immunity in Young Children.
abstract: We have explored the added value of interferon-γ (IFNγ)-inducible protein 10 as a read-out of Mycobacterium tuberculosis-specific immunity in young Indian children, where the sensitivity of the IFNγ release assays for tuberculosis is poor. Reduced frequency of indeterminate results and an increased sensitivity for tuberculosis suggest a potential for fewer missed cases with a combined IFNγ/inducible protein 10 read-out in a 4th generation IFNγ release assays.
authors.affiliation: From the *Department of Clinical Science, University of Bergen, Bergen, Norway; †Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway; ‡Department of Clinical Science, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway; §Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark; ¶Division of Infectious Diseases, St. John's Research Institute, Koramangala, Bangalore, India; and ‖GlaxoSmithKline, Vaccines, Wavre, Belgium.
authors.forename: Synne
authors.initials: S
authors.lastname: Jenum
authors.forename: Sivakumaran
authors.initials: S
authors.lastname: Dhanasekaran
authors.forename: Christian
authors.initials: C
authors.lastname: Ritz
authors.forename: Ragini
authors.initials: R
authors.lastname: Macaden
authors.forename: T Mark
authors.initials: TM
authors.lastname: Doherty
authors.forename: Harleen M S
authors.initials: HM
authors.lastname: Grewal
mesh_terms: D054357:Chemokine CXCL10 / Q000032:analysis* / Q000276:immunology; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007371:Interferon-gamma / Q000032:analysis* / Q000276:immunology; D059425:Interferon-gamma Release Tests / Q000379:methods*; D008297:Male; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D011446:Prospective Studies; D014374:Tuberculin Test; D014376:Tuberculosis / Q000175:diagnosis* / Q000276:immunology
chemical_list: C114753:CXCL10 protein, human; D054357:Chemokine CXCL10; D007371:Interferon-gamma