title: Fluorescence enhancement of glutathione capped CdTe/ZnS quantum dots by embedding into cationic starch for sensitive detection of rifampicin.
abstract: In this study, we describe the synthesis of a new quantum dots (QDs) by embedding glutathione capped CdTe/ZnS QDs into cationic starch biopolymer (CS-GSH-CdTe/ZnS QDs). The fluorescence intensity of prepared QDs was significantly enhanced. When QDs interacted with rifampicin, the fluorescence intensity of the CS-GSH-CdTe/ZnS QDs was highly quenched compared with GSH-CdTe/ZnS QDs. Based on the above, a new fluorescent nanosensor for simple, sensitive and selective detection of rifampicin was developed. The fluorescence quenching was well described by the typical Stern-Volmer equation. After optimization, the linear range of the as-prepared QDs fluorescence intensity versus the concentration of rifampicin was F0/F=0.0422Q+1.109 (R2=0.99). The detection limit was 0.06×10-6mol/L. The proposed method with satisfactory results was used to detect rifampicin in commercial capsules and tablets.
authors.affiliation: Department of Chemistry, Payame Noor University, PO BOX 19395-3697, Tehran, Iran.
authors.forename: Zari
authors.initials: Z
authors.lastname: Hooshyar
authors.affiliation: Department of Chemistry, Payame Noor University, PO BOX 19395-3697, Tehran, Iran. Electronic address: rezanejad@pnu.ac.ir.
authors.forename: Ghasem Rezanejade
authors.initials: GR
authors.lastname: Bardajee
mesh_terms: D019187:Cadmium Compounds / Q000737:chemistry; D002214:Capsules / Q000032:analysis; D005453:Fluorescence; D005978:Glutathione / Q000737:chemistry*; D057230:Limit of Detection; D046529:Microscopy, Electron, Transmission; D045663:Quantum Dots / Q000737:chemistry*; D012293:Rifampin / Q000032:analysis* / Q000737:chemistry; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence / Q000379:methods*; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013213:Starch / Q000737:chemistry; D013440:Sulfides / Q000737:chemistry; D013607:Tablets / Q000032:analysis; D013691:Tellurium / Q000737:chemistry; D013818:Thermogravimetry; D017967:Zinc Compounds / Q000737:chemistry
chemical_list: D019187:Cadmium Compounds; D002214:Capsules; D013440:Sulfides; D013607:Tablets; D017967:Zinc Compounds; D013213:Starch; D005978:Glutathione; C031238:zinc sulfide; D013691:Tellurium; C028337:cadmium telluride; D012293:Rifampin
keywords: Cationic starch; Drug determination; Nanosensor; Quantum dot