title: The role of IL-29 in immunity and cancer.
abstract: Interleukin-29 (IL-29) is a new member of the recently discovered interferon λ (IFNλ) family. It is produced predominantly by maturing dendritic cells and macrophages. It has been implicated in numerous immunological responses and has shown antiviral activity similar to the Type I interferons, although its target cell population is more limited than the Type I interferons. In recent years, the role of IL-29 in the pathogenesis of various cancers has also been extensively studied. In this review, we will discuss the recent advances of IL-29 in immunological processes and the pathogenesis of various cancer.
authors.affiliation: Department of Microbiology, Immunology & Pathology, Des Moines University, Des Moines, IA 50312, United States.
authors.forename: Noah E
authors.initials: NE
authors.lastname: Kelm
authors.affiliation: Department of Surgery, University of Missouri School of Medicine, Columbia, MO 65212, United States.
authors.forename: Ziwen
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Department of Microbiology, Immunology & Pathology, Des Moines University, Des Moines, IA 50312, United States.
authors.forename: Vivi A
authors.initials: VA
authors.lastname: Ding
authors.affiliation: Department of Microbiology, Immunology & Pathology, Des Moines University, Des Moines, IA 50312, United States; The Affiliated Hospital of Xiangnan University, Chenzhou, Hunan, China.
authors.forename: Huaping
authors.initials: H
authors.lastname: Xiao
authors.affiliation: Department of Surgery, University of Missouri School of Medicine, Columbia, MO 65212, United States.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Wakefield
authors.affiliation: Department of Surgery, University of Missouri School of Medicine, Columbia, MO 65212, United States.
authors.forename: Qian
authors.initials: Q
authors.lastname: Bai
authors.affiliation: Department of Microbiology, Immunology & Pathology, Des Moines University, Des Moines, IA 50312, United States; Department of Surgery, University of Missouri School of Medicine, Columbia, MO 65212, United States. Electronic address: yujiang.fang@dmu.edu.
authors.forename: Yujiang
authors.initials: Y
authors.lastname: Fang
mesh_terms: D000818:Animals; D006801:Humans; D007372:Interferons; D007378:Interleukins / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology*; D000095022:Interferon Lambda
chemical_list: D007372:Interferons; D007378:Interleukins; C000624353:interferon-lambda, human; D000095022:Interferon Lambda
keywords: Cancer; Cytokine; IL-29; Immune response