title: Atrophy and Depigmentation After Pretibial Corticosteroid Injection for Medial Tibial Stress Syndrome: Two Case Reports.
abstract: BACKGROUND
  No reports have been published on the results of corticosteroid injections for medial tibial stress syndrome (MTSS).
  
  
  METHODS
  The authors present 2 cases of women with MTSS who showed atrophy and depigmentation of the skin after pretibial corticosteroid injections. Case 1 is an 18-y-old woman presenting with pain in her lower leg for 12 mo. No improvement was noticed after conservative treatment, so she received local injections with corticosteroids. Five months later physical examination showed tissue atrophy and depigmentation around the injection sites. Case 2 is a 22-y-old woman who presented with pain in both lower legs for 24 mo. Several conservative treatment options failed, so she received local injections with corticosteroids. Physical examination revealed tissue atrophy and depigmentation around the injection sites.
  
  
  CONCLUSIONS
  No positive effect of injections with corticosteroids was found in 2 cases of MTSS. Furthermore, considerable tissue atrophy and hypopigmentation of the skin was observed.
authors.forename: Miette F
authors.initials: MF
authors.lastname: Loopik
authors.forename: Marinus
authors.initials: M
authors.lastname: Winters
authors.forename: Maarten H
authors.initials: MH
authors.lastname: Moen
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000009:adverse effects* / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001284:Atrophy / Q000139:chemically induced; D005260:Female; D006801:Humans; D017496:Hypopigmentation / Q000139:chemically induced*; D007267:Injections; D058923:Medial Tibial Stress Syndrome / Q000188:drug therapy*; D050151:Subcutaneous Fat / Q000187:drug effects* / Q000473:pathology*; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents
keywords: MTSS; side effects; treatment