title: Multimodal population brain imaging in the UK Biobank prospective epidemiological study.
abstract: Medical imaging has enormous potential for early disease prediction, but is impeded by the difficulty and expense of acquiring data sets before symptom onset. UK Biobank aims to address this problem directly by acquiring high-quality, consistently acquired imaging data from 100,000 predominantly healthy participants, with health outcomes being tracked over the coming decades. The brain imaging includes structural, diffusion and functional modalities. Along with body and cardiac imaging, genetics, lifestyle measures, biological phenotyping and health records, this imaging is expected to enable discovery of imaging markers of a broad range of diseases at their earliest stages, as well as provide unique insight into disease mechanisms. We describe UK Biobank brain imaging and present results derived from the first 5,000 participants' data release. Although this covers just 5% of the ultimate cohort, it has already yielded a rich range of associations between brain imaging and other measures collected by UK Biobank.
authors.affiliation: Oxford Centre for Functional MRI of the Brain (FMRIB), University of Oxford, Oxford, UK.
authors.forename: Karla L
authors.initials: KL
authors.lastname: Miller
authors.affiliation: Oxford Centre for Functional MRI of the Brain (FMRIB), University of Oxford, Oxford, UK.
authors.forename: Fidel
authors.initials: F
authors.lastname: Alfaro-Almagro
authors.affiliation: Department of Electrical Engineering, Brigham Young University, Provo, Utah, USA.
authors.forename: Neal K
authors.initials: NK
authors.lastname: Bangerter
authors.affiliation: Institute of Neurology, University College London, London, UK.
authors.forename: David L
authors.initials: DL
authors.lastname: Thomas
authors.affiliation: Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Essa
authors.initials: E
authors.lastname: Yacoub
authors.affiliation: Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Junqian
authors.identifier: 0000-0001-8438-2066
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Neuroradiology, University of Heidelberg, Heidelberg, Germany.
authors.forename: Andreas J
authors.initials: AJ
authors.lastname: Bartsch
authors.affiliation: Oxford Centre for Functional MRI of the Brain (FMRIB), University of Oxford, Oxford, UK.
authors.forename: Saad
authors.initials: S
authors.lastname: Jbabdi
authors.affiliation: Oxford Centre for Functional MRI of the Brain (FMRIB), University of Oxford, Oxford, UK.
authors.forename: Stamatios N
authors.initials: SN
authors.lastname: Sotiropoulos
authors.affiliation: Oxford Centre for Functional MRI of the Brain (FMRIB), University of Oxford, Oxford, UK.
authors.forename: Jesper L R
authors.initials: JL
authors.lastname: Andersson
authors.affiliation: Oxford Centre for Functional MRI of the Brain (FMRIB), University of Oxford, Oxford, UK.
authors.forename: Ludovica
authors.initials: L
authors.lastname: Griffanti
authors.affiliation: Oxford Centre for Functional MRI of the Brain (FMRIB), University of Oxford, Oxford, UK.
authors.forename: Gwenaëlle
authors.initials: G
authors.lastname: Douaud
authors.affiliation: Oxford Centre for Functional MRI of the Brain (FMRIB), University of Oxford, Oxford, UK.
authors.forename: Thomas W
authors.identifier: 0000-0001-8258-0659
authors.initials: TW
authors.lastname: Okell
authors.affiliation: Siemens Healthcare UK, Frimley, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Weale
authors.affiliation: Siemens Healthcare UK, Frimley, UK.
authors.forename: Iulius
authors.initials: I
authors.lastname: Dragonu
authors.affiliation: UK Biobank, Stockport, UK.
authors.forename: Steve
authors.initials: S
authors.lastname: Garratt
authors.affiliation: UK Biobank, Stockport, UK.
authors.forename: Sarah
authors.initials: S
authors.lastname: Hudson
authors.affiliation: UK Biobank, Stockport, UK.|Nuffield Department of Population Health, University of Oxford, Oxford, UK.
authors.forename: Rory
authors.initials: R
authors.lastname: Collins
authors.affiliation: Oxford Centre for Functional MRI of the Brain (FMRIB), University of Oxford, Oxford, UK.
authors.forename: Mark
authors.initials: M
authors.lastname: Jenkinson
authors.affiliation: Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Matthews
authors.affiliation: Oxford Centre for Functional MRI of the Brain (FMRIB), University of Oxford, Oxford, UK.
authors.forename: Stephen M
authors.identifier: 0000-0001-8166-069X
authors.initials: SM
authors.lastname: Smith
mesh_terms: D000328:Adult; D000368:Aged; D018070:Biological Specimen Banks; D001921:Brain / Q000166:cytology*; D016021:Epidemiologic Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging; D011446:Prospective Studies; D012307:Risk Factors; D006113:United Kingdom