title: Use of an Octapeptide-Guanidiniocarbonylpyrrole Conjugate for the Formation of a Supramolecular β-Helix that Self-Assembles into pH-Responsive Fibers.
abstract: Peptides that adopt β-helix structures are predominantly found in transmembrane protein domains or in the lipid bilayer of vesicles. Constructing a β-helix structure in pure water has been considered difficult without the addition of membrane mimics. Herein, we report such an example; peptide 1 self-assembles into a supramolecular β-helix in pure water based on charge interactions between the individual peptides. Peptide 1 further showed intriguing transitions from small particles to helical fibers in a time-dependent process. The fibers can be switched to vesicles by changing the pH value.
authors.affiliation: Institute for Organic Chemistry, University of Duisburg-Essen, 45117, Essen, Germany.
authors.forename: Mao
authors.initials: M
authors.lastname: Li
authors.affiliation: Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Zagreb, Croatia.
authors.forename: Marijana
authors.initials: M
authors.lastname: Radić Stojković
authors.affiliation: Institute for Organic Chemistry, University of Duisburg-Essen, 45117, Essen, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Ehlers
authors.affiliation: Institute for Organic Chemistry, University of Duisburg-Essen, 45117, Essen, Germany.
authors.forename: Elio
authors.initials: E
authors.lastname: Zellermann
authors.affiliation: Institute for Organic Chemistry, University of Duisburg-Essen, 45117, Essen, Germany.
authors.forename: Ivo
authors.initials: I
authors.lastname: Piantanida
authors.affiliation: Institute for Organic Chemistry, University of Duisburg-Essen, 45117, Essen, Germany. carsten.schmuck@uni-due.de.
authors.forename: Carsten
authors.initials: C
authors.lastname: Schmuck
keywords: ion pair formation; molecular recognition; peptide fibers; peptide structures; self-assembly