title: Neuropsychiatric Profile in Malaria: An Overview.
abstract: BACKGROUND
  Malaria is the most important parasitic disease of humans causes clinical illness over 300-500 million people globally and over one million death every year globally. The involvement of the nervous system in malaria is studied in this paper, to help formulate a strategy for better malaria management.
  
  
  OBJECTIVE
  To study the Neuropsychiatric manifestation in malaria.
  
  
  METHODS
  This was a prospective observational study in 170 patients with a clinical diagnosis of malaria admitted in various medical wards of medicine department of PBM Hospital, Bikaner during epidemic of malaria. It included both sexes of all age groups except the paediatric range. The diagnosis of malaria was confirmed by examination of thick and thin smear/optimal test/strip test. Only those cases that had asexual form of parasite of malaria in the blood by smear examination or optimal test were included in the study.
  
  
  RESULTS
  Out of total 170 patients 104 (62%) reported Plasmodium falciparum (PF), Plasmodium vivax (PV) were 57 (33.5%) followed by mixed (PF+PV) 9 (5.3%) cases. The total PBF-MP test positivity was 84.5%. Maximum patients were belonging to the age range of 21-40 year with male predominance. Neuropsychiatric manifestation seen in falciparum malaria (n=111) as follow: altered consciousness 20 (18.01%), headache 17 (15.32%), neck rigidity 5 (4.5%), convulsion 5 (4.55%), extra pyramidal rigidity 2 (1.8%), decorticate rigidity 1 (0.90%), decerebrate rigidity 1 (0.90%), cerebellar ataxia 3 (2.7%), subarachnoid haemorrhage 1 (0.90%), aphasia 2 (1.8%), subconjunctival haemorrhage 1 (0.90%), conjugate deviation of eye 1 (0.90%) and psychosis 6 (5.40%). Twenty one patients presented with cerebral malaria out of 111 patients. Most patients of cerebral malaria presented with altered level of consciousness followed by headache and psychosis. Acute confusional state with clouding of consciousness was the most common presentation of psychosis (50%).
  
  
  CONCLUSIONS
  Neuropsychiatric manifestations are not an uncommon presentation of malaria. Most commonly caused by PF malaria. Malaria should be thought as a differential diagnosis in pyrexia with neuropsychiatric manifestation. Observation obtained in the study will be highly useful for the diagnosis and management of patients suffering from malaria.
authors.affiliation: Senior Professor, Department of Medicine, SP Medical College , Bikaner, Rajasthan, India .
authors.forename: Veer Bahadur
authors.initials: VB
authors.lastname: Singh
authors.affiliation: Senior Resident, Department of Medicine, SP Medical College , Bikaner, Rajasthan, India .
authors.forename: Harish
authors.initials: H
authors.lastname: Kumar
authors.affiliation: Assistant Professor, Department of Medicine, SP Medical College , Bikaner, Rajasthan, India .
authors.forename: Babu Lal
authors.initials: BL
authors.lastname: Meena
authors.affiliation: Assistant Professor, Department of Medicine, SP Medical College , Bikaner, Rajasthan, India .
authors.forename: Subhash
authors.initials: S
authors.lastname: Chandra
authors.affiliation: Registrar, Department of Medicine, SP Medical College , Bikaner, Rajasthan, India .
authors.forename: Jatin
authors.initials: J
authors.lastname: Agrawal
authors.affiliation: Student, Department of Medicine, SP Medical College , Bikaner, Rajasthan, India .
authors.forename: Naresh
authors.initials: N
authors.lastname: Kanogiya
keywords: Neuropsychiatric manifestation; Plasmodium falciparum; Plasmodium vivax