title: Continuous venovenous hemofiltration combined with hemoperfusion for toxic epidermal necrolysis: a retrospective cohort study.
abstract: OBJECTIVE
  The current treatments of toxic epidermal necrolysis (TEN) are limited to the discontinuation of a suspect medication and supportive measures. We conducted a retrospective study to evaluate the efficacy of adding continuous venovenous hemofiltration (CVVH) and hemoperfusion (HP) to the conventional treatment for TEN.
  
  
  METHODS
  TEN patients who were admitted to our center between January 2008 and May 2016 were considered as candidates. The included patients were divided into the CVVH&HP group (n = 34) and the conventional group (n = 34) according to their accepted therapies during hospital stay.
  
  
  RESULTS
  The patients in the conventional group had a significantly reduced 28-day survival proportion compared with patients in the CVVH&HP group (73.5 versus 91.2%, p = .047). The adjusted results demonstrated that the conventional group had a significantly higher risk of 28-day mortality as well. Moreover, patients in the CVVH&HP group were associated with significantly shorter hospital stay, rash, fever, and antibiotic durations. However, the addition of CVVH&HP to conventional treatment did not significantly increase the in-hospital cost.
  
  
  CONCLUSIONS
  In conclusion, CVVH&HP might be a safe and effective adjuvant therapy for TEN. Further well-designed studies are warranted to obtain robust evidence.
authors.affiliation: a Department of Nephrology , Xijing Hospital, the Fourth Military Medical Univerisity , Shaanxi , China.
authors.forename: Ming
authors.initials: M
authors.lastname: Bai
authors.affiliation: a Department of Nephrology , Xijing Hospital, the Fourth Military Medical Univerisity , Shaanxi , China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yu
authors.affiliation: a Department of Nephrology , Xijing Hospital, the Fourth Military Medical Univerisity , Shaanxi , China.
authors.forename: Chen
authors.initials: C
authors.lastname: Huang
authors.affiliation: a Department of Nephrology , Xijing Hospital, the Fourth Military Medical Univerisity , Shaanxi , China.
authors.forename: Yirong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: a Department of Nephrology , Xijing Hospital, the Fourth Military Medical Univerisity , Shaanxi , China.
authors.forename: Meilan
authors.initials: M
authors.lastname: Zhou
authors.affiliation: a Department of Nephrology , Xijing Hospital, the Fourth Military Medical Univerisity , Shaanxi , China.
authors.forename: Yangping
authors.initials: Y
authors.lastname: Li
authors.affiliation: a Department of Nephrology , Xijing Hospital, the Fourth Military Medical Univerisity , Shaanxi , China.
authors.forename: Feng
authors.initials: F
authors.lastname: Ma
authors.affiliation: a Department of Nephrology , Xijing Hospital, the Fourth Military Medical Univerisity , Shaanxi , China.
authors.forename: Rui
authors.initials: R
authors.lastname: Jing
authors.affiliation: a Department of Nephrology , Xijing Hospital, the Fourth Military Medical Univerisity , Shaanxi , China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Zhao
authors.affiliation: a Department of Nephrology , Xijing Hospital, the Fourth Military Medical Univerisity , Shaanxi , China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: a Department of Nephrology , Xijing Hospital, the Fourth Military Medical Univerisity , Shaanxi , China.
authors.forename: Pengbo
authors.initials: P
authors.lastname: Wang
authors.affiliation: a Department of Nephrology , Xijing Hospital, the Fourth Military Medical Univerisity , Shaanxi , China.
authors.forename: Lijie
authors.initials: L
authors.lastname: He
authors.affiliation: a Department of Nephrology , Xijing Hospital, the Fourth Military Medical Univerisity , Shaanxi , China.
authors.forename: Shiren
authors.initials: S
authors.lastname: Sun
mesh_terms: D000328:Adult; D005260:Female; D006440:Hemofiltration / Q000379:methods*; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D013262:Stevens-Johnson Syndrome / Q000401:mortality / Q000628:therapy*; D015996:Survival Rate
keywords: Stevens–Johnson syndrome; Toxic epidermal necrolysis; continuous venovenous hemofiltration; glucocorticoids; hemoperfusion