title: Looping around Bcl6 in Germinal Center to Sharpen B Cell Immunity.
abstract: We are beginning to understand the function of 3D genome architecture in the immune system. In this issue, Bunting et al. (2016) reported massive multi-layer genome reorganization from naive B cells to germinal center B cells, centered on a locus control region of Bcl6.
authors.affiliation: Systems Biology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA.
authors.forename: Gangqing
authors.initials: G
authors.lastname: Hu
authors.affiliation: Systems Biology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA. Electronic address: zhaok@nhlbi.nih.gov.
authors.forename: Keji
authors.initials: K
authors.lastname: Zhao
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D018858:Germinal Center / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D051560:Proto-Oncogene Proteins c-bcl-6 / Q000276:immunology* / Q000378:metabolism*
chemical_list: D051560:Proto-Oncogene Proteins c-bcl-6