title: Marrow Fat Quality Differences by Sex in Healthy Adults.
abstract: Several studies have demonstrated the relationship between bone marrow adiposity (BMAT) and bone mass.1H magnetic resonance spectroscopy is a noninvasive technique able to assess both BMAT quantity and quality. The aim of our study was to perform quantitative and qualitative analyses of BMAT and to investigate its association with bone mineral density (BMD) in healthy nonobese volunteers. Fifty-one healthy volunteers, 21 men and 30 women, underwent 1.5 T1H magnetic resonance spectroscopy of the lumbar spine. BMD was determined by dual-energy X-ray absorptiometry of the lumbar spine. Correlation analysis was performed to evaluate association among lipids fractions, BMD, and age. The female and male volunteers had similar body mass index and BMD (p > 0.05). Our data demonstrated an inverse correlation of BMD and BMAT with age, with a stronger correlation of saturated lipids (r = 0.701; p < 0.0001) compared with unsaturated lipids (UL) (r = 0.278; p = 0.004). Importantly, female subjects had the highest amount of UL (confidence interval: 0.685%-1.722%; p < 0.001). Our study reports that men and women with similar BMD and body mass index have striking differences in bone marrow lipids composition, namely women have higher UL than men. In addition, we believe that our study brings new insights to the complex network involving BMAT and other factors that influence bone integrity.
authors.affiliation: Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo (USP), Ribeirão Preto, Brazil. Electronic address: jamillygomes@fmrp.usp.br.
authors.forename: Jamilly G
authors.initials: JG
authors.lastname: Maciel
authors.affiliation: Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo (USP), Ribeirão Preto, Brazil.
authors.forename: Iana M
authors.initials: IM
authors.lastname: de Araújo
authors.affiliation: Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo (USP), Ribeirão Preto, Brazil.
authors.forename: Adriana L
authors.initials: AL
authors.lastname: Carvalho
authors.affiliation: Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo (USP), Ribeirão Preto, Brazil.
authors.forename: Marcelo N
authors.initials: MN
authors.lastname: Simão
authors.affiliation: Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo (USP), Ribeirão Preto, Brazil.
authors.forename: Clara M
authors.initials: CM
authors.lastname: Bastos
authors.affiliation: Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo (USP), Ribeirão Preto, Brazil.
authors.forename: Luiz E A
authors.initials: LE
authors.lastname: Troncon
authors.affiliation: Department of Physics, Faculty of Philosophy, Sciences and Arts of Ribeirao Preto, University of Sao Paulo (USP), Ribeirão Preto, Brazil.
authors.forename: Carlos E G
authors.initials: CE
authors.lastname: Salmon
authors.affiliation: Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo (USP), Ribeirão Preto, Brazil.
authors.forename: Francisco J A
authors.initials: FJ
authors.lastname: de Paula
authors.affiliation: Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo (USP), Ribeirão Preto, Brazil.
authors.forename: Marcello H
authors.initials: MH
authors.lastname: Nogueira-Barbosa
mesh_terms: D015502:Absorptiometry, Photon; D000273:Adipose Tissue / Q000000981:diagnostic imaging* / Q000378:metabolism; D000328:Adult; D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D015519:Bone Density; D001853:Bone Marrow / Q000000981:diagnostic imaging* / Q000378:metabolism; D005223:Fats / Q000378:metabolism; D005224:Fats, Unsaturated / Q000378:metabolism; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D066244:Proton Magnetic Resonance Spectroscopy; D012737:Sex Factors; D055815:Young Adult
chemical_list: D005223:Fats; D005224:Fats, Unsaturated
keywords: Bone marrow adiposity; MR spectroscopy; bone mineral density; unsaturated lipids