title: Combined Diffusion Tensor Imaging and Arterial Spin Labeling as Markers of Early Parkinson's disease.
abstract: This study aimed to identify a PD-specific MRI pattern using combined diffusion tensor imaging (DTI) and arterial spin labeling (ASL) to discriminate patients with early PD from healthy subjects and evaluate disease status. Twenty-one early and 22 mid-late PD patients, and 22 healthy, age/gender-matched controls underwent 3-T MRI with apparent diffusion coefficient (ADC), fractional anisotropy (FA), fiber number (FN) and cerebral blood flow (CBF) measurements. We found that compared with healthy subjects, there was a profound reduction in FN passing through the SN in PD. FA in the SN and CBF in the caudate nucleus were inversely correlated with motor dysfunction. A negative correlation was observed between FA in the hippocampus (Hip) and the NMSS-Mood score, whereas CBF in the Hip and the prefrontal cortex(PFC) correlated with declined cognition. Stratified five-fold cross-validation identified FA in the SN(FA-SNAv), CBF in the PFC(CBF-PFCAv) and FA in the parietal white matter(FA-PWMAv), and the combination of these measurements offered relatively high accuracy (AUC 0.975, 90% sensitivity and 100% specificity) in distinguishing those with early PD from healthy subjects. We demonstrate that the decreased FNs through SN in combination with changes in FA-SNAv, CBF-PFCAv and FA-PWMAv values might serve as potential markers of early-stage PD.
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Tianhe Road 600, Guangzhou, Guangdong 510630, China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Wei
authors.affiliation: Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Tianhe Road 600, Guangzhou, Guangdong 510630, China.
authors.forename: Ronghua
authors.initials: R
authors.lastname: Yan
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Tianhe Road 600, Guangzhou, Guangdong 510630, China.
authors.forename: Zhaoyu
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Tianhe Road 600, Guangzhou, Guangdong 510630, China.
authors.forename: Ruihui
authors.initials: R
authors.lastname: Weng
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Tianhe Road 600, Guangzhou, Guangdong 510630, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Tianhe Road 600, Guangzhou, Guangdong 510630, China.
authors.forename: Huimin
authors.initials: H
authors.lastname: Gao
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Tianhe Road 600, Guangzhou, Guangdong 510630, China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Tianhe Road 600, Guangzhou, Guangdong 510630, China.
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Kang
authors.affiliation: School of biomedical Engineering, Southern Medical University, Guangzhou, Guangdong 510515, China.
authors.forename: Zhexing
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, #74 Zhongshan 2nd Road, Guangzhou, Guangdong 510080, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Liu
authors.affiliation: The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Box 8100, N-4068 Stavanger, Norway.
authors.forename: Jan Petter
authors.initials: JP
authors.lastname: Larsen
authors.affiliation: Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Tianhe Road 600, Guangzhou, Guangdong 510630, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Neurology and The State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan 410078 China.
authors.forename: Beisha
authors.initials: B
authors.lastname: Tang
authors.affiliation: Human Motor Control Section, NINDS, NIH, Bethesda, MD 20892-1428 Stavanger, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Hallett
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Tianhe Road 600, Guangzhou, Guangdong 510630, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000368:Aged; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000000981:diagnostic imaging*; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging*; D013113:Spin Labels
chemical_list: D013113:Spin Labels