title: Hypoadiponectinemia, elevated iron and high-sensitivity C-reactive protein levels and their relation with prostate size in benign prostatic hyperplasia.
abstract: Elevated iron, high-sensitivity C-reactive protein (CRP) and hypoadiponectinemia are known to initiate tumour development. There is paucity of data regarding the above-mentioned parameters and their relation with prostate size in benign prostatic hyperplasia (BPH). The present study was designed to assess the levels of iron, hs-CRP and adiponectin levels and their association with prostate size in BPH patients. A total of 37 BPH cases and 36 controls were enrolled in the study. Iron, hs-CRP and adiponectin were estimated in both the groups. Iron and hs-CRP were significantly increased and adiponectin was significantly reduced in BPH cases when compared with controls. Iron (r = .397, p = .015), hs-CRP (r = .341, p = .039) and adiponectin (r = -.464, p = .004) were significantly associated with prostate size in BPH cases. Multivariate linear regression analysis showed that iron acts as predictor of prostate size in BPH (R2= 0.395, β = 0.526, p = .001). We conclude that iron and hs-CRP are elevated and adiponectin is reduced in BPH cases and associated with prostate size.
authors.affiliation: Department of Biochemistry and Urology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
authors.forename: H
authors.initials: H
authors.lastname: Nandeesha
authors.affiliation: Department of Biochemistry and Urology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
authors.forename: A
authors.initials: A
authors.lastname: Eldhose
authors.affiliation: Department of Biochemistry and Urology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
authors.forename: L N
authors.initials: LN
authors.lastname: Dorairajan
authors.affiliation: Department of Biochemistry and Urology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
authors.forename: B
authors.initials: B
authors.lastname: Anandhi
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000172:deficiency*; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D006801:Humans; D007501:Iron / Q000097:blood*; D008297:Male; D008661:Metabolism, Inborn Errors / Q000097:blood* / Q000150:complications; D008875:Middle Aged; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood; D011470:Prostatic Hyperplasia / Q000097:blood* / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000097:blood; D012307:Risk Factors
chemical_list: D052242:Adiponectin; D002097:C-Reactive Protein; D007501:Iron; D017430:Prostate-Specific Antigen
keywords: C-reactive protein; adiponectin; benign prostatic hyperplasia; iron; prostate-specific antigen