title: Interleukin-6 polymorphisms and risk of coronary artery diseases in a Chinese population: A case-control study.
abstract: OBJECTIVE
  We aimed to evaluate the relationship between IL-6-174G>C, -572G>C and -597G>A polymorphisms and development of coronary artery diseases in a Chinese population.
  
  
  METHODS
  A total of 275 patients with coronary artery disease and 296 healthy control subjects were collected between January 2013 and November 2014. The IL-6 genotyping for -174G>C, -592G>C and -597G>A polymorphic sites was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) according to the manufacturer instructions.
  
  
  RESULTS
  Using unconditional regression analysis, we observed that the AC and CC genotypes of IL-6 -592A>C were associated with the increased risk of developing coronary artery disease when compared with the AA genotype, and the adjusted ORs (95%CI) were 1.63(1.12-2.38) and 2.70(1.57-4.67), respectively. Additionally, the C allele of IL-6 -592A>C (OR=1.65, 95%CI=1.29-2.11) was correlated with a higher risk of developing coronary artery disease in comparison to the A allele. However, no relationship was found between IL-6-174G>C and -597G>A polymorphisms and coronary artery disease susceptibility.
  
  
  CONCLUSIONS
  This study suggests that IL-6 -592G>C polymorphism is correlated with the risk of coronary artery disease. More well-designed prospective studies based on large sample size, multiple SNPs or haplotypes are required to confirm the current findings.
authors.affiliation: Yao Hongmei, Department of Cardiology, The First Hospital of Shanxi Medical University, No. 85 Xinjiannan Road, Taiyuan 030001, Shanxi, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Hongmei
authors.affiliation: Jia Yongping, Department of Cardiology, The First Hospital of Shanxi Medical University, No. 85 Xinjiannan Road, Taiyuan 030001, Shanxi, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Yongping
authors.affiliation: Lv Jiyuan, Department of Cardiology, The First Hospital of Shanxi Medical University, No. 85 Xinjiannan Road, Taiyuan 030001, Shanxi, China.
authors.forename: Lv
authors.initials: L
authors.lastname: Jiyuan
keywords: -174G>C; -572G>C; -597G>A; Coronary artery disease; Interleukin-6; Polymorphism