title: Long-lasting monoaminergic and behavioral dysfunctions in a mice model of socio-environmental stress during adolescence.
abstract: Adolescence is one of the critical periods of development and has great importance to health for an individual as an adult. Stressors or traumatic events during this period are associated with several psychiatric disorders as related to anxiety or depression and cognitive impairments, but whether negative experiences continue to hinder individuals as they age is not as well understood. We determined how stress during adolescence affects behavior and neurochemistry in adulthood. Using an unpredictable paradigm (2 stressors per day for 10days) in Balb/c mice, behavioral, hormonal, and neurochemical changes were identified 20days after the cessation of treatment. Adolescent stress increased motor activity, emotional arousal and vigilance, together with a reduction in anxiety, and also affected recognition memory. Furthermore, decreased serotonergic activity on hippocampus, hypothalamus and cortex, decreased noradrenergic activity on hippocampus and hypothalamus, and increased the turnover of dopamine in cortex. These data suggest behavioral phenotypes associated with emotional arousal, but not depression, emerge after cessation of stress and remain in adulthood. Social-environmental stress can induce marked and long-lasting changes in HPA resulting from monoaminergic neurotransmission, mainly 5-HT activity.
authors.affiliation: Department of Pathology, School of Veterinary Medicine, University of São Paulo, São Paulo, Brazil. Electronic address: paulanlima@gmail.com.
authors.forename: A P N
authors.initials: AP
authors.lastname: de Lima
authors.affiliation: Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address: thaisasandini@gmail.com.
authors.forename: T M
authors.initials: TM
authors.lastname: Sandini
authors.affiliation: Department of Neuroscience and Behavior, Psychology Institute, University of São Paulo, São Paulo, Brazil. Electronic address: thiago.mreis@usp.br.
authors.forename: T M
authors.initials: TM
authors.lastname: Reis-Silva
authors.affiliation: Department of Pathology, School of Veterinary Medicine, University of São Paulo, São Paulo, Brazil. Electronic address: cmassoco@gmail.com.
authors.forename: C O
authors.initials: CO
authors.lastname: Massoco
mesh_terms: D000311:Adrenal Glands / Q000473:pathology; D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D002940:Circadian Rhythm / Q000502:physiology; D003345:Corticosterone / Q000097:blood; D003623:Dark Adaptation / Q000502:physiology; D004195:Disease Models, Animal; D004777:Environment; D005106:Exploratory Behavior / Q000502:physiology; D019417:Hindlimb Suspension; D008297:Male; D001523:Mental Disorders / Q000209:etiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D021641:Recognition, Psychology / Q000502:physiology; D012919:Social Behavior; D013315:Stress, Psychological / Q000150:complications / Q000378:metabolism / Q000473:pathology
chemical_list: D015306:Biogenic Monoamines; D003345:Corticosterone
keywords: Adolescence; Behavior; Corticosterone; Mice; Neurochemistry; Unpredictable stress