title: Age and gender effects on bone mass density variation: finite elements simulation.
abstract: Bone remodeling is a physiological process by which bone constantly adapts its structure to changes in long-term loading manifested by interactions between osteoclasts and osteoblasts. This process can be influenced by many local factors, via effects on bone cells differentiation and proliferation, which are produced by bone cells and act in a paracrine or autocrine way. The aim of the current work is to provide mechanobiological finite elements modeling coupling both cellular activities and mechanical behavior in order to investigate age and gender effects on bone remodeling evolution. A series of computational simulations have been performed on a 2D and 3D human proximal femur. An age- and gender-related impacts on bulk density alteration of trabecular bone have been noticed, and the major actors responsible of this phenomenon have been then discussed.
authors.affiliation: Laboratoire de Mécanique Appliquée et Ingénierie (LR-MAI), Ecole Nationale d'Ingénieurs de Tunis, LR-11-ES19, Université de Tunis El Manar, 1002, Tunis, Tunisie. abdelwahed.barkaoui@ipeiem.utm.tn.
authors.forename: Abdelwahed
authors.identifier: 0000-0001-7268-5860
authors.initials: A
authors.lastname: Barkaoui
authors.affiliation: Laboratoire de Mécanique Appliquée et Ingénierie (LR-MAI), Ecole Nationale d'Ingénieurs de Tunis, LR-11-ES19, Université de Tunis El Manar, 1002, Tunis, Tunisie.
authors.forename: Rabeb
authors.initials: R
authors.lastname: Ben Kahla
authors.affiliation: Laboratoire Ingénierie des Systèmes de Versailles, Université de Versailles St Quentin en Yvelines, 10 avenue del'Europe, 78140, Velizy, France.
authors.forename: Tarek
authors.initials: T
authors.lastname: Merzouki
authors.affiliation: PRISME Laboratory, EA4229, University of Orleans Polytech' Orléans, 8, Rue Léonard de Vinci, 45072, Orléans, France.
authors.forename: Ridha
authors.initials: R
authors.lastname: Hambli
mesh_terms: D000367:Age Factors; D015519:Bone Density / Q000502:physiology*; D016723:Bone Remodeling; D003198:Computer Simulation; D005260:Female; D005269:Femur / Q000502:physiology; D020342:Finite Element Analysis; D006801:Humans; D008297:Male; D008954:Models, Biological; D012737:Sex Factors
keywords: Age; Bone remodeling; Finite elements method; Mass density