title: DNA Binding and Recognition of a CC Mismatch in a DNA Duplex by Water-Soluble Peptidocalix[4]arenes: Synthesis and Applications.
abstract: Water-soluble peptidocalix[4]arenes were synthesized by the introduction of arginine-rich narrow groove-binding residues at lower rims through solid-phase synthesis. The study of binding of these water-soluble bidentate ligands to well-matched and mismatched DNA duplexes by fluorescent titrations, ethidium bromide (EB) displacement assays, DNA-melting experiments, and circular dichroism (CD) analysis revealed a sequence-dependent groove-binding mechanism.
authors.affiliation: Chemistry and Chemical Engineering Research Center of Iran , P.O. Box 14335-186, Tehran 1496813151, Iran.
authors.forename: Nahid S
authors.initials: NS
authors.lastname: Alavijeh
authors.affiliation: Chemistry and Chemical Engineering Research Center of Iran , P.O. Box 14335-186, Tehran 1496813151, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Zadmard
authors.affiliation: Peptide Chemistry Research Center, K.N. Toosi University of Technology , P.O. Box 15875-4416, Tehran 1969764499, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Balalaie
authors.affiliation: Pharmidex Pharmaceutical Services, Limited, London W1S 1YH, U.K.
authors.forename: Mohammad S
authors.initials: MS
authors.lastname: Alavijeh
authors.affiliation: Department of Chemistry, Sharif University of Technology , P.O. Box 11155-3516, Tehran 1458889694, Iran.
authors.forename: Nima
authors.initials: N
authors.lastname: Soltani
mesh_terms: D001482:Base Composition; D020137:Base Pair Mismatch; D001483:Base Sequence; D001665:Binding Sites; D047250:Calixarenes / Q000138:chemical synthesis* / Q000737:chemistry; D002942:Circular Dichroism; D003596:Cytosine / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D008024:Ligands; D009842:Oligopeptides; D014867:Water; D047250:Calixarenes; D003596:Cytosine; D004247:DNA