title: Vasculogenesis and Its Cellular Therapeutic Applications.
abstract: Vasculogenesis was originally defined by Risau in 1997 [Nature 386: 671-674] as the de novo formation of vessels from endothelial progenitor cells (EPCs), so-called angioblasts. Initially, this process was believed to be related only to embryonic life; however, further studies reported vasculogenesis to occur also in adult tissues. This overview presents the current knowledge about the origin, differentiation and significance of EPCs that have been observed in various diseases, tumors, and reparative processes. We also summarize the knowledge of how to activate these cells for therapeutic purposes and the outcomes of the therapies.
authors.affiliation: Department of Pathology, Center for Biostructure, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Ratajska
authors.forename: Ewa
authors.initials: E
authors.lastname: Jankowska-Steifer
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Czarnowska
authors.forename: Radosław
authors.initials: R
authors.lastname: Olkowski
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Gula
authors.forename: Justyna
authors.initials: J
authors.lastname: Niderla-Bielińska
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Flaht-Zabost
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Jasińska
mesh_terms: D000818:Animals; D064987:Cell- and Tissue-Based Therapy; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D047108:Embryonic Development; D066026:Endothelial Progenitor Cells / Q000166:cytology; D006801:Humans; D018919:Neovascularization, Physiologic