title: Metabolic control of epigenetics in cancer.
abstract: Alterations in the epigenome and metabolism both affect molecular rewiring in cancer cells and facilitate cancer development and progression. However, recent evidence suggests the existence of important bidirectional regulatory mechanisms between metabolic remodelling and the epigenome (specifically methylation and acetylation of histones) in cancer. Most chromatin-modifying enzymes require substrates or cofactors that are intermediates of cell metabolism. Such metabolites, and often the enzymes that produce them, can transfer into the nucleus, directly linking metabolism to nuclear transcription. We discuss how metabolic remodelling can contribute to tumour epigenetic alterations, thereby affecting cancer cell differentiation, proliferation and/or apoptosis, as well as therapeutic responses.
authors.affiliation: Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.|Division of Urology, Department of Surgery, University of Alberta, Edmonton, Alberta T6G 2R7, Canada.
authors.forename: Adam
authors.initials: A
authors.lastname: Kinnaird
authors.affiliation: Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
authors.forename: Kathryn E
authors.initials: KE
authors.lastname: Wellen
authors.affiliation: Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Evangelos D
authors.initials: ED
authors.lastname: Michelakis
mesh_terms: D000107:Acetylation; D002477:Cells / Q000378:metabolism*; D019175:DNA Methylation; D044127:Epigenesis, Genetic / Q000235:genetics* / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism*