title: Papillary Squamotransitional Cell Carcinoma of the Uterine Cervix: A Case Report and Review of the Literature.
abstract: Introduction. Papillary squamotransitional cell carcinoma (PSTCC) is an uncommon histopathological variant of squamous cell carcinoma (SCC) of the uterine cervix, which occurs in postmenopausal women. Presentation of Case. Herein, we describe a case of a 63-year-old woman who presented with 4-month history of postmenopausal vaginal bleeding. Vaginal examination revealed a fragile lesion of size 1 × 1 cm invading left posterior vaginal fornice and parametrium. Biopsy showed the presence of papillae containing fibrovascular cores lined by multilayered atypical epithelial cells resembling squamous and transitional cell epithelium, confirming the diagnosis of PSTCC of the uterine cervix. After staging work-up she was staged according to the International Federation of Gynecology and Obstetrics (FIGO) staging system 2009 as FIGO IIB, and she was started on extended field concurrent chemoradiation. Discussion. PSTCC of the uterine cervix is an extremely rare and aggressive entity. PSTCC is often characterized by the presence of papillary structures with prominent fibrovascular cores. PSTCC of the uterine cervix should be differentiated from transitional cell carcinoma, squamous papilloma, papillary adenocarcinoma, and cervical intraepithelial neoplasia with papillary features. Conclusion. PSTCC of the uterine cervix is a diagnostic challenge; further studies regarding the mechanism underlying the development of PSCC are warranted.
authors.affiliation: Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh 59046, Saudi Arabia.
authors.forename: Shomaila Aamir M
authors.identifier: 0000-0001-9493-9091
authors.initials: SA
authors.lastname: Akbar
authors.affiliation: Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh 59046, Saudi Arabia.
authors.forename: Mutahir A
authors.identifier: 0000-0001-8764-288X
authors.initials: MA
authors.lastname: Tunio
authors.affiliation: Surgical Pathology, Department of Pathology and Laboratory Medicine Administration, King Fahad Medical City, Riyadh 59046, Saudi Arabia; King Saud bin Abdulaziz University, Riyadh, Saudi Arabia; King Saud University, Riyadh, Saudi Arabia.
authors.forename: Sadeq
authors.identifier: 0000-0003-3373-7327
authors.initials: S
authors.lastname: Al-Dandan
authors.affiliation: Gynecology Oncology, Women's Hospital, King Fahad Medical City, Riyadh 59046, Saudi Arabia.
authors.forename: Kareema Mohammed Y
authors.initials: KM
authors.lastname: Salamah
authors.affiliation: Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh 59046, Saudi Arabia.
authors.forename: Mushabbab
authors.initials: M
authors.lastname: AlAsiri