title: Genetic association of Toll-like receptor 4 gene and coronary artery disease in a Chinese Han population.
abstract: OBJECTIVE
  Toll-like receptor 4 (TLR4) is known to be involved in innate immunity and inflammatory responses that play important roles in the pathogenesis of coronary artery disease (CAD). But the relationship between TLR4 gene and CAD has yet to be investigated. The present study aimed to evaluate the association of TLR4 gene polymorphisms with CAD susceptibility in a Chinese Han population.
  
  
  METHODS
  A total of 1094 subjects (577 unrelated patients with CAD and 517 controls) were recruited between 2008 and 2012. Three tag SNPs (rs1927907, rs1927911 and rs11536889) present in the TLR4 gene were genotyped using Sequenom Mass-ARRAY system.
  
  
  RESULTS
  The genotypic distributions of the three SNPs were not deviate from Hardy-Weinberg equilibrium. There was no significant difference in distributions of allelic frequencies of each SNPs between healthy controls and CAD patients (P > 0.05). Genotype frequencies of TLR4 gene did not show any statistically significant difference between the two groups in co-dominant, dominant or recessive genetic models (P > 0.05). The frequency of haplotypes in the case group was similar to that in the control group (P > 0.05).
  
  
  CONCLUSIONS
  TLR4 gene do not relate to genetic susceptibility of CAD in the Chinese Han population.
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Jilin University, 1163 Xin Min Street, Changchun, 130021 China.
authors.forename: Liting
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Jilin University, 1163 Xin Min Street, Changchun, 130021 China.
authors.forename: Dongchun
authors.initials: D
authors.lastname: Zheng
authors.affiliation: Department of Emergency, China-Japan Union Hospital, Jilin University, Changchun, China.
authors.forename: Shuyue
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Jilin University, 1163 Xin Min Street, Changchun, 130021 China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Jilin University, 1163 Xin Min Street, Changchun, 130021 China.
authors.forename: Yiyang
authors.initials: Y
authors.lastname: Jia
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Jilin University, 1163 Xin Min Street, Changchun, 130021 China.
authors.forename: Di
authors.initials: D
authors.lastname: Sun
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Jilin University, 1163 Xin Min Street, Changchun, 130021 China.
authors.forename: Jin
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Jilin University, 1163 Xin Min Street, Changchun, 130021 China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Jilin University, 1163 Xin Min Street, Changchun, 130021 China.
authors.forename: Huaiji
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Jilin University, 1163 Xin Min Street, Changchun, 130021 China.
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Jilin University, 1163 Xin Min Street, Changchun, 130021 China.
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Jilin University, 1163 Xin Min Street, Changchun, 130021 China.
authors.forename: Lin
authors.initials: L
authors.lastname: Ye
keywords: Coronary artery disease; Gene polymorphism; Toll-like receptor 4