title: The Comparison of Effectiveness of Various Potential Predictors of Response to Treatment With SSRIs in Patients With Depressive Disorder.
abstract: The substantial non-response rate in depressive patients indicates a continuing need to identify predictors of treatment outcome. The aim of this 6-week, open-label study was (1) to compare the efficacy of a priori defined predictors: ≥20% reduction in MADRS score at week 1, ≥20% reduction in MADRS score at week 2 (RM ≥ 20% W2), decrease of cordance (RC), and increase of serum and plasma level of brain-derived neurotrophic factor at week 1; and (2) to assess whether their combination yields higher efficacy in the prediction of response to selective serotonin re-uptake inhibitors (SSRIs) than when used singly. Twenty-one patients (55%) achieved a response to SSRIs. The RM ≥20% W2 (areas under curve-AUC = 0.83) showed better predictive efficacy compared to all other predictors with the exception of RC. The identified combined model (RM ≥ 20% W2 + RC), which predicted response with an 84% accuracy (AUC = 0.92), may be a useful tool in the prediction of response to SSRIs.
authors.affiliation: National Institute of Mental Health Czech Republic, Klecany; and Department of Psychiatry and Medical Psychology of Third Medical Faculty, Charles University, Prague, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Bares
authors.forename: Tomas
authors.initials: T
authors.lastname: Novak
authors.forename: Martin
authors.initials: M
authors.lastname: Brunovsky
authors.forename: Miloslav
authors.initials: M
authors.lastname: Kopecek
authors.forename: Cyril
authors.initials: C
authors.lastname: Höschl
mesh_terms: D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D003865:Major Depressive Disorder / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D061218:Depressive Disorder, Treatment-Resistant / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D004569:Electroencephalography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011237:Predictive Value of Tests; D017397:Prefrontal Cortex / Q000503:physiopathology*; D011379:Prognosis; D011569:Psychiatric Status Rating Scales; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D013826:Theta Rhythm / Q000502:physiology
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D017367:Selective Serotonin Reuptake Inhibitors; C579455:BDNF protein, human