title: Comparison of clinicopathological and prognostic characteristics in patients with mucinous carcinoma and signet ring cell carcinoma of the stomach.
abstract: To determine whether there are any clinicopathological or prognostic differences between mucinous gastric carcinoma (MGC) and signet ring cell carcinoma (SRCC).
  
  
  
  Pathological parameters, clinical parameters, and treatment efficacy were compared in patients with MGC and SRCC.
  
  
  
  In total, 193 patients (51 with MGC and 142 with SRCC) were included in this study. Patients with SRCC in particular had notably higher lymphovascular invasion, perineural invasion, rate of Borrmann types III and IV, and stage III-IV cancer (according to its TNM stage) compared with patients with MGC. However, tumor size was larger in patients with MGC (tumor size ≥5 cm). Median overall survival (OS) was 29.8 months in the MGC group and 16.6 months in the SRCC group (p = .04). The median OS in stage I-III patients was 59.9 and 42.5 months in the MGC and SRCC groups, respectively (p = .35). Comparing OS between MGC and SRCC stage IV patients revealed that the median OS was 10.1 and 8.8 months, respectively (p = .96). Multivariate analysis of the entire patient group revealed that the presence of weight loss at diagnosis, distant metastasis, and lymph node involvement were significantly related to OS. Multivariate analysis also revealed that weight loss at the diagnosis and T3-4 tumors were significant factors influencing OS in the stage I-III group.
  
  
  
  Patients with SRCC had generally poorer prognosis and lower survival rates compared with patients with MGC. Further studies on the prognosis and treatment plan based on the pathological subtypes of SRCC and MGC are still needed.
authors.affiliation: a Ankara Numune Education and Research Hospital, Department of Medical Oncology , Ankara , Turkey.
authors.forename: Yakup
authors.initials: Y
authors.lastname: Bozkaya
authors.affiliation: a Ankara Numune Education and Research Hospital, Department of Medical Oncology , Ankara , Turkey.
authors.forename: Gökmen Umut
authors.initials: GU
authors.lastname: Erdem
authors.affiliation: a Ankara Numune Education and Research Hospital, Department of Medical Oncology , Ankara , Turkey.
authors.forename: Nuriye Yıldırın
authors.initials: NY
authors.lastname: Ozdemir
authors.affiliation: a Ankara Numune Education and Research Hospital, Department of Medical Oncology , Ankara , Turkey.
authors.forename: Nebi Serkan
authors.initials: NS
authors.lastname: Demirci
authors.affiliation: a Ankara Numune Education and Research Hospital, Department of Medical Oncology , Ankara , Turkey.
authors.forename: Cemil
authors.initials: C
authors.lastname: Hocazade
authors.affiliation: a Ankara Numune Education and Research Hospital, Department of Medical Oncology , Ankara , Turkey.
authors.forename: Ozan
authors.initials: O
authors.lastname: Yazıcı
authors.affiliation: a Ankara Numune Education and Research Hospital, Department of Medical Oncology , Ankara , Turkey.
authors.forename: Nurullah
authors.initials: N
authors.lastname: Zengin
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000401:mortality / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018279:Carcinoma, Signet Ring Cell / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology*
keywords: Gastric cancer; mucin; mucinous gastric carcinoma; signet ring cell carcinoma