title: Eosinophilic tubulointerstitial nephritis on treatment with isotretinoin.
abstract: Drug-related acute tubulointerstitial nephritis is one of the most common causes of childhood acute renal failures which originate from kidneys. Sixteen-year old male patient with the history of isotretinoin use for the last 3 months was admitted with acute renal failure. Renal function parameters were measured as follows: blood urea nitrogen 21 mg/dL, serum creatinine 1.68 mg/dL, cystatin C 1.15 mg/L, and estimated glomerular filtration rate based on cystatin C 56.5 mL/min/1.73 m2. The patient whom pathological signs of renal biopsy sections revealed interstitial mononuclear cell and eosinophilic infiltration was diagnosed with acute tubulointerstitial nephritis.
  
  
  CONCLUSIONS
  Isotretinoin is a vitamin A-derived agent which is commonly used in the treatment of acne and may cause drug-related acute tubulointerstitial nephritis. What is Known: •Drug-related acute tubulointerstitial nephritis (ATIN) is one of the most common causes of childhood acute renal failures. What is New: •Isotretinoin may cause drug-related acute tubulointerstitial nephritis.
authors.affiliation: Department of Pediatric Nephrology, Akdeniz University, School of Medicine, Antalya, Turkey. gkayaaksoy@gmail.com.|Department of Pediatric Nephrology, Akdeniz University Medical Faculty, 07070, Antalya, Turkey. gkayaaksoy@gmail.com.
authors.forename: Gulsah
authors.initials: G
authors.lastname: Kaya Aksoy
authors.affiliation: Department of Pediatric Nephrology, Akdeniz University, School of Medicine, Antalya, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Koyun
authors.affiliation: Department of Pathology, Akdeniz University, School of Medicine, Antalya, Turkey.
authors.forename: Bahar
authors.initials: B
authors.lastname: Akkaya
authors.affiliation: Department of Pediatric Nephrology, Akdeniz University, School of Medicine, Antalya, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Comak
authors.affiliation: Department of Pediatric Nephrology, Akdeniz University, School of Medicine, Antalya, Turkey.
authors.forename: Atilla
authors.initials: A
authors.lastname: Gemici
authors.affiliation: Department of Pediatric Nephrology, Akdeniz University, School of Medicine, Antalya, Turkey.
authors.forename: Sema
authors.initials: S
authors.lastname: Akman
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy; D058186:Acute Kidney Injury / Q000139:chemically induced*; D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D003879:Dermatologic Agents / Q000009:adverse effects*; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects*; D007668:Kidney / Q000473:pathology; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced*; D011239:Prednisolone / Q000008:administration & dosage
chemical_list: D000893:Anti-Inflammatory Agents; D003879:Dermatologic Agents; D011239:Prednisolone; D015474:Isotretinoin
keywords: Acute tubulointerstitial nephritis; Drug-related tubulointerstitial nephritis; Isotretinoin; Renal failure