title: The impact of ovarian stimulation on the outcome of intrauterine insemination treatment: an analysis of 8893 cycles.
abstract: OBJECTIVE
  To evaluate the impact of ovarian stimulation on the outcome of intrauterine insemination (IUI).
  
  
  METHODS
  Retrospective analysis.
  
  
  METHODS
  A single university-based centre.
  
  
  METHODS
  A total of 5109 couples with 8893 cycles.
  
  
  METHODS
  The outcome of IUI with different protocols for ovarian stimulation was examined.
  
  
  METHODS
  The live birth rate (LBR), twin pregnancy rate and ovarian hyperstimulation syndrome (OHSS).
  
  
  RESULTS
  In ovulatory women without ovarian stimulation, the LBR was 7.6%. Stimulation with clomifene citrate (CC), letrozole (LE), human menopausal gonadotrophin (HMG), CC or LE combined with HMG achieved LBRs of 6.1, 5, 7.9, 8 and 12.2%, respectively. LE combined with HMG achieved a significantly improved LBR compared with no stimulation. HMG stimulation was associated with a higher rate of twins (7.4%) than no stimulation (0%, P < 0.01). In ovulatory women, the LBR appeared lower in CC and LE compared with no stimulation (P > 0.05). In anovulatory women, ovarian stimulation with CC, LE, HMG, CC or LE combined with HMG achieved LBRs of 11.3, 5.1, 11.8, 12.6 and 13.6%, respectively. No significant difference was observed. There were no triplet pregnancies or OHSS in stimulated cycles.
  
  
  CONCLUSIONS
  In ovulatory women, ovarian stimulation with LE combined with HMG achieved a significantly improved live birth rate. HMG stimulation resulted in a high risk for twins.
  
  
  CONCLUSIONS
  In ovulatory women, ovarian stimulation with letrozole and HMG resulted in a significantly improved LBR.
authors.affiliation: The State Key Laboratory of Reproductive Medicine, Clinical Centre of Reproductive Medicine, First Affiliated Hospital of Nanjing Medical University, Hong Kong, China.
authors.forename: Jinyong
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Obstetrics and Gynaecology, Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Tin-Chiu
authors.initials: TC
authors.lastname: Li
authors.affiliation: The State Key Laboratory of Reproductive Medicine, Clinical Centre of Reproductive Medicine, First Affiliated Hospital of Nanjing Medical University, Hong Kong, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: The State Key Laboratory of Reproductive Medicine, Clinical Centre of Reproductive Medicine, First Affiliated Hospital of Nanjing Medical University, Hong Kong, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: The State Key Laboratory of Reproductive Medicine, Clinical Centre of Reproductive Medicine, First Affiliated Hospital of Nanjing Medical University, Hong Kong, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Hou
authors.affiliation: The State Key Laboratory of Reproductive Medicine, Clinical Centre of Reproductive Medicine, First Affiliated Hospital of Nanjing Medical University, Hong Kong, China. jyliu_nj@126.com.
authors.forename: Jiayin
authors.initials: J
authors.lastname: Liu
mesh_terms: D002681:China / Q000453:epidemiology; D002996:Clomiphene; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007315:Insemination, Artificial / Q000379:methods*; D000077289:Letrozole; D050498:Live Birth / Q000453:epidemiology*; D008183:Luteal Phase / Q000502:physiology; D009570:Nitriles; D016471:Ovarian Hyperstimulation Syndrome / Q000139:chemically induced / Q000453:epidemiology*; D010062:Ovulation Induction / Q000706:statistics & numerical data; D011247:Pregnancy; D018873:Pregnancy Rate; D059285:Pregnancy, Twin / Q000706:statistics & numerical data*; D018456:Reproductive Medicine; D012189:Retrospective Studies; D016896:Treatment Outcome; D014230:Triazoles
chemical_list: D009570:Nitriles; D014230:Triazoles; D002996:Clomiphene; D000077289:Letrozole
keywords: Clomifene citrate; human menopausal gonadotrophin; intrauterine insemination; letrozole; live birth rate; ovarian stimulation; 卵巢促排卵; 宫腔内人工授精; 尿促性素; 来曲唑; 活产率