title: Asymmetric Synthesis of Apratoxin E.
abstract: An efficient method for asymmetric synthesis of apratoxin E 2 is described in this report. The chiral lactone 8, recycled from the degradation of saponin glycosides, was utilized to prepare the non-peptide fragment 6. In addition to this "from nature to nature" strategy, olefin cross-metathesis (CM) was applied as an alternative approach for the formation of the double bond. Moreover, pentafluorophenyl diphenylphosphinate was found to be an efficient condensation reagent for the macrocyclization.
authors.affiliation: Department of Natural Products Chemistry, School of Pharmacy, Fudan University , 826 Zhangheng Road, Shanghai 201203, China.|Institutes of Biomedical Sciences, Fudan University , 130 Dongan Road, Shanghai 200032, China.
authors.forename: Zhuo-Ya
authors.initials: ZY
authors.lastname: Mao
authors.affiliation: Department of Natural Products Chemistry, School of Pharmacy, Fudan University , 826 Zhangheng Road, Shanghai 201203, China.
authors.forename: Chang-Mei
authors.initials: CM
authors.lastname: Si
authors.affiliation: Institutes of Biomedical Sciences, Fudan University , 130 Dongan Road, Shanghai 200032, China.
authors.forename: Yi-Wen
authors.initials: YW
authors.lastname: Liu
authors.affiliation: Institutes of Biomedical Sciences, Fudan University , 130 Dongan Road, Shanghai 200032, China.
authors.forename: Han-Qing
authors.initials: HQ
authors.lastname: Dong
authors.affiliation: Department of Natural Products Chemistry, School of Pharmacy, Fudan University , 826 Zhangheng Road, Shanghai 201203, China.
authors.forename: Bang-Guo
authors.initials: BG
authors.lastname: Wei
authors.affiliation: Department of Natural Products Chemistry, School of Pharmacy, Fudan University , 826 Zhangheng Road, Shanghai 201203, China.|Institutes of Biomedical Sciences, Fudan University , 130 Dongan Road, Shanghai 200032, China.
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Lin