title: Hepatitis B Virus (HBV) Load Response to 2 Antiviral Regimens, Tenofovir/Lamivudine and Lamivudine, in HIV/ HBV-Coinfected Pregnant Women in Guangxi, China: The Tenofovir in Pregnancy (TiP) Study.
abstract: BACKGROUND
  There is limited information on antiviral therapy for hepatitis B virus (HBV) infection among pregnant women coinfected with human immunodeficiency virus (HIV) and HBV.
  
  
  METHODS
  A phase 2 randomized, controlled trial of a regimen containing tenofovir (TDF)/lamivudine (3TC) and a regimen containing 3TC in HIV/HBV-coinfected pregnant women in China. The HBV virological response was compared in study arms.
  
  
  RESULTS
  The median decline in the HBV DNA level was 2.60 log10copies/mL in the TDF/3TC arm and 2.24 log10copies/mL in the 3TC arm (P = .41). All women achieved HBV DNA levels of <6 log10copies/mL at delivery.
  
  
  CONCLUSIONS
  Initiation of either regimen led to achievement of HBV DNA levels below the threshold associated with perinatal HBV transmission.
  
  
  BACKGROUND
  NCT01125696.
authors.affiliation: Global AIDS Program China Office, Division of HIV and Tuberculosis, Center for Global Health, US Centers for Disease Control and Prevention (CDC).|Beijing Ditan Hospital.|Clinical Center for HIV/AIDS, Capital Medical University.
authors.forename: Liming
authors.initials: L
authors.lastname: Wang
authors.affiliation: Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Wiener
authors.affiliation: Global AIDS Program China Office, Division of HIV and Tuberculosis, Center for Global Health, US Centers for Disease Control and Prevention (CDC).|Center for Global Health, CDC, Atlanta, Georgia.
authors.forename: Marc
authors.initials: M
authors.lastname: Bulterys
authors.affiliation: Global AIDS Program China Office, Division of HIV and Tuberculosis, Center for Global Health, US Centers for Disease Control and Prevention (CDC).
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Wei
authors.affiliation: Guangxi Zhuang Autonomous Region Health and Family Planning Commission.
authors.forename: Lili
authors.initials: L
authors.lastname: Chen
authors.affiliation: Guangxi Provincial Center for Disease Control and Prevention, Nanning, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Guangxi Provincial Center for Disease Control and Prevention, Nanning, China.
authors.forename: Shujia
authors.initials: S
authors.lastname: Liang
authors.affiliation: Global AIDS Program China Office, Division of HIV and Tuberculosis, Center for Global Health, US Centers for Disease Control and Prevention (CDC).|Center for Global Health, CDC, Atlanta, Georgia.
authors.forename: Colin
authors.initials: C
authors.lastname: Shepard
authors.affiliation: National Center for Women and Children's Health.
authors.forename: Linhong
authors.initials: L
authors.lastname: Wang
authors.affiliation: National Center for Women and Children's Health.
authors.forename: Ailing
authors.initials: A
authors.lastname: Wang
authors.affiliation: Beijing Ditan Hospital.|Clinical Center for HIV/AIDS, Capital Medical University.|National Center for AIDS/STD Prevention and Control, Chinese Center for Disease Control and Prevention, Beijing.
authors.forename: Fujie
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion.
authors.forename: Athena P
authors.initials: AP
authors.lastname: Kourtis
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage*; D002681:China; D060085:Coinfection / Q000188:drug therapy; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D006509:Hepatitis B / Q000150:complications / Q000188:drug therapy*; D006515:Hepatitis B virus / Q000302:isolation & purification; D006801:Humans; D019259:Lamivudine / Q000008:administration & dosage*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D000068698:Tenofovir / Q000008:administration & dosage*; D016896:Treatment Outcome; D019562:Viral Load; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D019259:Lamivudine; D000068698:Tenofovir
keywords: HBV DNV viral load; HBV suppression; HIV/HBV coinfection; lamivudine; pregnancy; tenofovir