title: Renal Denervation in a Real Life Setting: A Gradual Decrease in Home Blood Pressure.
abstract: OBJECTIVE
  To investigate the blood pressure dynamics after renal denervation through monthly home blood pressure measurements throughout the first 12 months.
  
  
  METHODS
  A cohort of 70 patients performed highly standardized monthly home blood pressure monitoring during the first year after denervation according to the European Society of Hypertension guidelines. At baseline and 12 months follow-up, office and ambulatory blood pressure as well as routine physical and laboratory assessment was performed.
  
  
  RESULTS
  Home blood pressure decreased with a rate of 0.53 mmHg/month (95% CI 0.20 to 0.86) systolic and 0.26 mmHg/month (95% CI 0.08 to 0.44) diastolic throughout 12 months of follow-up, while the use of antihypertensive medication remained stable (+0.03 daily defined doses/month, 95% CI -0.01 to 0.08). On average, a 12 month reduction of 8.1 mmHg (95% CI 4.2 to 12.0) was achieved in home systolic blood pressure, 9.3 mmHg (95% CI -14.2 to -4.4) as measured by 24-hour ambulatory blood pressure monitoring and 15.9 mmHg (95% CI -23.8 to -7.9) on office measurements.
  
  
  CONCLUSIONS
  Blood pressure reduction after renal denervation occurs as a gradual decrease that extends to at least one-year follow-up. Home monitoring seems a suitable alternative for ambulatory blood pressure monitoring after renal denervation.
authors.affiliation: Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
authors.forename: Martine M A
authors.initials: MM
authors.lastname: Beeftink
authors.affiliation: Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
authors.forename: Wilko
authors.initials: W
authors.lastname: Spiering
authors.affiliation: Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
authors.forename: Michiel L
authors.initials: ML
authors.lastname: Bots
authors.affiliation: Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
authors.forename: Willemien L
authors.initials: WL
authors.lastname: Verloop
authors.affiliation: Department of Nephrology & Hypertension, University Medical Center Utrecht, Utrecht, the Netherlands.
authors.forename: Rosa L
authors.initials: RL
authors.lastname: De Jager
authors.affiliation: Department of Nephrology & Hypertension, University Medical Center Utrecht, Utrecht, the Netherlands.
authors.forename: Margreet F
authors.initials: MF
authors.lastname: Sanders
authors.affiliation: Department of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands.
authors.forename: Evert-Jan
authors.initials: EJ
authors.lastname: Vonken
authors.affiliation: Department of Nephrology & Hypertension, University Medical Center Utrecht, Utrecht, the Netherlands.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Blankestijn
authors.affiliation: Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
authors.forename: Michiel
authors.initials: M
authors.lastname: Voskuil
mesh_terms: D000368:Aged; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D003714:Denervation; D005260:Female; D006801:Humans; D007668:Kidney / Q000294:innervation* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged