title: The Therapeutic Potential of Differentiated Lung Cells from Embryonic Stem Cells in Lung Diseases.
abstract: Lung diseases cause great morbidity and mortality. The choice of effective medical treatment is limited and the number of lung diseases are difficult to treat with current treatments. The embryonic stem cells (ESCs) have the potential to differentiate into cell types of all three germinal layers, including lung epithelial cells. So they can be a potential source for new cell therapies for hereditary or acquired diseases of the airways and lungs. One method for treatment of lung diseases is cell therapy and the use of ESCs that can replace the damaged epithelial and endothelial cells. Progress using ESCs has developed slowly for lung regeneration because differentiation of lung cells from ESCs is more difficult as compared to differentiation of other cells. The review studies the therapeutic effects of differentiated lung cells from embryonic stem cells in lung diseases. There are few studies of differentiation of ESCs into a lineage of respiratory and then investigation of this cell in experimental model of lung diseases.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Mokhber Dezfouli
authors.affiliation: Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
authors.forename: Sirous Sadeghian
authors.initials: SS
authors.lastname: Chaleshtori
authors.forename: Mohammad Mehdi
authors.initials: MM
authors.lastname: Dehghan
authors.forename: Hamid
authors.initials: H
authors.lastname: Tavanaeimanesh
authors.forename: Hossein
authors.initials: H
authors.lastname: Baharvand
authors.forename: Yaser
authors.initials: Y
authors.lastname: Tahamtani
mesh_terms: D002454:Cell Differentiation; D019070:Cell Lineage; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D053595:Embryonic Stem Cells / Q000166:cytology* / Q000637:transplantation*; D042783:Endothelial Cells / Q000166:cytology; D004847:Epithelial Cells / Q000166:cytology; D006801:Humans; D008168:Lung / Q000166:cytology*; D008171:Lung Diseases / Q000628:therapy*; D012038:Regeneration / Q000502:physiology