title: Dietary Nitrate Acutely and Markedly Increased Exhaled Nitric Oxide in a Cystic Fibrosis Case.
abstract: Airway nitric oxide (NO) is a ubiquitous signaling molecule with bronchoprotective, anti-inflammatory and anti-infective roles. Cystic fibrosis (CF) is a chronic lung condition associated with deceased exhaled NO. Strategies to increase exhaled NO in CF have yielded inconsistent results. A potential new method of increasing systemic NO involves ingestion of dietary, inorganic nitrate which is reduced to nitrite and NO. We present the case of a 12-year-old, athletic boy with CF who demonstrated acute but marked increases in exhaled NO following dietary nitrate consumption compared to placebo.
authors.affiliation: Paediatric Respiratory Department, National Children's Hospital, Dublin 24, Ireland conorkerley@gmail.com.|School of Medicine and Medical Sciences, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Conor P
authors.initials: CP
authors.lastname: Kerley
authors.affiliation: Paediatric Respiratory Department, National Children's Hospital, Dublin 24, Ireland.
authors.forename: Emma
authors.initials: E
authors.lastname: Kilbride
authors.affiliation: Paediatric Respiratory Department, National Children's Hospital, Dublin 24, Ireland.
authors.forename: Peter
authors.initials: P
authors.lastname: Greally
authors.affiliation: Paediatric Respiratory Department, National Children's Hospital, Dublin 24, Ireland.
authors.forename: Basil
authors.initials: B
authors.lastname: Elnazir
mesh_terms: D001120:Arginine / Q000737:chemistry; D002648:Child; D003550:Cystic Fibrosis / Q000178:diet therapy* / Q000503:physiopathology*; D004032:Diet; D045853:Exhalation; D006801:Humans; D007249:Inflammation; D007501:Iron / Q000737:chemistry; D008297:Male; D009566:Nitrates / Q000737:chemistry*; D009569:Nitric Oxide / Q000737:chemistry*; D009573:Nitrites / Q000737:chemistry; D010919:Placebos; D012129:Respiratory Function Tests; D016896:Treatment Outcome
chemical_list: D009566:Nitrates; D009573:Nitrites; D010919:Placebos; D009569:Nitric Oxide; D001120:Arginine; D007501:Iron
keywords: Cystic fibrosis; Dietary nitrate; Exhaled nitric oxide; Nitrite