title: Lipid accumulation product as a marker of cardiometabolic susceptibility in women with different phenotypes of polycystic ovary syndrome.
abstract: OBJECTIVE
  There are limited data on cardiometabolic risk factors and the prevalence of metabolic syndrome (MetS) across the different PCOS phenotypes in Caucasian population. Lipid accumulation product (LAP) is a clinical surrogate marker that could be used for evaluation of MetS in clinical practice. The aim of the study was to analyze metabolic characteristics and the ability of LAP to predict MetS in different PCOS phenotypes.
  
  
  METHODS
  Cross-sectional clinical study analyzing 365 women with PCOS divided into four phenotypes according to the ESHRE/ASRM criteria, and 125 healthy BMI-matched controls.
  
  
  METHODS
  In all subjects, LAP was determined and MetS was diagnosed according to the National Cholesterol Education Program/Adult Treatment Panel III (NCEP-ATP III), the International Diabetes Federation (IDF) and the Joint Interim Statement (JIS) criteria. Logistic regression and ROC curve analyses were used to determine predictors of MetS in each PCOS phenotype. All analyses were performed with age and BMI adjustment.
  
  
  RESULTS
  All PCOS phenotypes in comparison to controls had higher prevalence of MetS assessed by NCEP-ATP III criteria, and only classic phenotypes when IDF and JIS criteria were used. All phenotypes had the same prevalence of MetS irrespective of used definition. LAP and exhibited the highest diagnostic accuracy and was an independent predictor of MetS in all phenotypes.
  
  
  CONCLUSIONS
  LAP is an independent and accurate clinical determinant of MetS in all PCOS phenotypes in our Caucasian population. All PCOS phenotypes, including non-classic ones, are metabolically challenged and with cardiovascular risk, particularly phenotype B.
authors.affiliation: Clinic of EndocrinologyDiabetes and Metabolic Diseases, Clinical Centre of Serbia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Božić-Antić
authors.affiliation: Clinic of EndocrinologyDiabetes and Metabolic Diseases, Clinical Centre of Serbia.
authors.forename: Dušan
authors.initials: D
authors.lastname: Ilić
authors.affiliation: UMC Bežanijska kosaFaculty of Medicine.
authors.forename: Jelica
authors.initials: J
authors.lastname: Bjekić-Macut
authors.affiliation: Clinic of EndocrinologyDiabetes and Metabolic Diseases, Clinical Centre of Serbia.
authors.forename: Tamara
authors.initials: T
authors.lastname: Bogavac
authors.affiliation: Institute for Biological Research "Siniša Stanković".
authors.forename: Danijela
authors.initials: D
authors.lastname: Vojnović-Milutinović
authors.affiliation: Clinic of Obstetrics and GynecologyClinical Centre of Serbia.
authors.forename: Biljana
authors.initials: B
authors.lastname: Kastratovic-Kotlica
authors.affiliation: Institute of Medical Statistics.
authors.forename: Nataša
authors.initials: N
authors.lastname: Milić
authors.affiliation: Institute of Medical PhysiologyFaculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Olivera
authors.initials: O
authors.lastname: Stanojlović
authors.affiliation: UMC Bežanijska kosaFaculty of Medicine.
authors.forename: Zoran
authors.initials: Z
authors.lastname: Andrić
authors.affiliation: Clinic of EndocrinologyDiabetes and Metabolic Diseases, Clinical Centre of Serbia djmacut@gmail.com.
authors.forename: Djuro
authors.initials: D
authors.lastname: Macut
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004198:Disease Susceptibility / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006801:Humans; D064237:Lipid Accumulation Product / Q000502:physiology*; D024821:Metabolic Syndrome / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D055815:Young Adult
chemical_list: D015415:Biomarkers