title: Respiratory-motion artefacts in liver MRI following injection of gadoxetate disodium and gadobenate dimeglumine: an intra-individual comparative study in cirrhotic patients.
abstract: OBJECTIVE
  To perform an intra-individual comparison of the frequency of respiratory-motion artefacts on magnetic resonance imaging (MRI) in cirrhotic patients following injection of gadoxetate disodium and gadobenate dimeglumine.
  
  
  METHODS
  Ninety-five cirrhotic patients (61 men and 34 women, mean age 58 years) underwent liver MRI with intravenous administration of gadoxetate disodium and gadobenate dimeglumine at different times (interval between studies, 189±83 days). Three readers scored the severity of respiratory-motion artefacts on the three-dimensional (3D) gradient-echo (GRE) images acquired before and after contrast medium injection. McNemar's test was used to assess the difference in frequency of new respiratory-motion artefacts and transient severe motion (TSM) artefacts between gadoxetate disodium and gadobenate dimeglumine MRI studies. The association between clinical and technical features and the occurrence of TSM on gadoxetate disodium MRI studies was investigated.
  
  
  RESULTS
  On arterial phase images, new respiratory-motion artefacts were present in 32/95 (34%) cases after injection of gadoxetate disodium, while only seen in 2/95 (2%) cases after injection of gadobenate dimeglumine (p<0.0001). TSM was present in 6/95 (6%) cases after injection of gadoxetate disodium, and in 0/95 (0%) case after injection of gadobenate dimeglumine. No clinical or technical features were associated with the occurrence of TSM.
  
  
  CONCLUSIONS
  In cirrhotic patients, respiratory-motion artefacts on arterial phase 3D GRE images are more frequently seen after injection of gadoxetate disodium than after injection of gadobenate dimeglumine.
authors.affiliation: Department of Radiology, University of Pittsburgh, UPMC Presbyterian Shadyside, Radiology, Suite 200, East Wing, 200 Lothrop Street, Pittsburgh, PA 15213, USA. Electronic address: furlana@upmc.edu.
authors.forename: A
authors.initials: A
authors.lastname: Furlan
authors.affiliation: Department of Radiology, University of Pittsburgh, UPMC Presbyterian Shadyside, Radiology, Suite 200, East Wing, 200 Lothrop Street, Pittsburgh, PA 15213, USA.
authors.forename: O N
authors.initials: ON
authors.lastname: Close
authors.affiliation: Department of Radiology, University of Pittsburgh, UPMC Presbyterian Shadyside, Radiology, Suite 200, East Wing, 200 Lothrop Street, Pittsburgh, PA 15213, USA.
authors.forename: A A
authors.initials: AA
authors.lastname: Borhani
authors.affiliation: Chengdu University of Traditional Chinese Medicine, No 1166 Liutai Avenue, Wenjiang District, Chengdu, Sichuan, China.
authors.forename: Y H
authors.initials: YH
authors.lastname: Wu
authors.affiliation: Department of Radiology, University of Pittsburgh, UPMC Presbyterian Shadyside, Radiology, Suite 200, East Wing, 200 Lothrop Street, Pittsburgh, PA 15213, USA.
authors.forename: M T
authors.initials: MT
authors.lastname: Heller
mesh_terms: D016477:Artifacts; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D019786:Gadolinium DTPA / Q000008:administration & dosage*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007275:Injections, Intravenous; D008099:Liver / Q000000981:diagnostic imaging; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging*; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008536:Meglumine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008875:Middle Aged; D009038:Motion; D009942:Organometallic Compounds / Q000008:administration & dosage*; D015203:Reproducibility of Results; D015656:Respiratory Mechanics; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C073590:gadolinium ethoxybenzyl DTPA; C064572:gadobenic acid; D008536:Meglumine; D019786:Gadolinium DTPA