title: Cognitive Function, APOE Gene Polymorphisms, and Thyroid Status Associations in Postmenopausal Women in Poland.
abstract: The objective of the study was to analyze a potential association between cognitive functions and thyroid status in postmenopausal women with different polymorphisms of the apolipoprotein E gene (APOE).
  
  
  
  The examined population included 402 postmenopausal women from south-eastern Poland. The evaluation of cognitive functions was made with the use of the diagnostic Central Nervous System-Vital Signs equipment (Polish version). Multiplex polymerase chain reactions were performed to assess APOE polymorphisms. The thyroid hormone tests were assessed by an accredited laboratory.
  
  
  
  Lower results of cognitive functions were associated with the presence of the ε4 APOE allele in postmenopausal women. The ε4 APOE polymorphism was associated with a higher concentration of thyroid-stimulating hormone and lower concentrations of free triiodothyronine and total triiodothyronine.
authors.affiliation: Department for Health Problems of Ageing, Institute of Rural Health, Lublin, Poland.
authors.forename: Iwona
authors.initials: I
authors.lastname: Bojar
authors.forename: Magdalena
authors.initials: M
authors.lastname: Stasiak
authors.forename: Anna
authors.initials: A
authors.lastname: Cyniak-Magierska
authors.forename: Dorota
authors.initials: D
authors.lastname: Raczkiewicz
authors.forename: Andrzej
authors.initials: A
authors.lastname: Lewiński
mesh_terms: D000483:Alleles; D053327:Apolipoprotein E4 / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D001323:Autoantibodies; D003071:Cognition; D060825:Cognitive Dysfunction / Q000453:epidemiology* / Q000235:genetics / Q000523:psychology; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000453:epidemiology* / Q000235:genetics / Q000523:psychology; D007453:Iodide Peroxidase / Q000276:immunology; D008875:Middle Aged; D009483:Neuropsychological Tests; D011044:Poland; D011110:Polymorphism, Genetic; D017698:Postmenopause; D011989:Receptors, Thyrotropin / Q000276:immunology; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D001323:Autoantibodies; D011989:Receptors, Thyrotropin; D014284:Triiodothyronine; D013972:Thyrotropin; D007453:Iodide Peroxidase; D013974:Thyroxine