title: Effect of Antihypertensive Drugs on Uric Acid Metabolism in Patients with Hypertension: Cross-Sectional Cohort Study.
abstract: Background:Hypertension is a common complication in patients with gout and/or hyperuricemia. Besides, hyperuricemia is a risk factor of gout as well as ischemic heart disease in hypertensive patients. Moreover, the risk of gout is modified by antihypertensive drugs. However, it remains unclear how antihypertensive agents affect uric acid metabolism.Purpose:In the present study, we investigated the uric acid metabolism in treated hypertensive patients to find out whether any of them would influence serum levels of uric acid.Patients and methods:751 hypertensive patients (313 men and 438 women) under antihypertensive treatment were selected. Blood pressure (BP), serum uric acid (SUA) and serum creatinine (Scr) were measured and evaluated statistically.Results:In patients treated with diuretics, beta-blockers and/or alpha-1 blockers SUA levels were significantly higher than in patients who were not taking these drugs. Besides, the estimated glomerular filtration rate (eGFR) in patients treated with diuretics, beta-blockers and/or alpha-1 blockers was negatively correlated with SUA level. There were gender differences in the effects of beta-blockers and alpha-1 blockers. Multiple regression analysis indicated that both diuretics and beta-blockers significantly contributed to hyperuricemia in patients with medication for hypertension.Conclusion:Diuretics, beta-blockers and alpha-1 blockers reduced glomerular filtration rate and raised SUA levels. Calcium channel blockers, ACE inhibitors and angiotensin receptor blockers, including losartan, did not increase SUA levels.
authors.affiliation: Division of Regenerative Medicine and Therapeutics, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University, Yonago, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ueno
authors.affiliation: Department of Community-based Family Medicine, Tottori University Faculty of Medicine, Yonago, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hamada
authors.affiliation: Department of Community-based Family Medicine, Tottori University Faculty of Medicine, Yonago, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Taniguchi
authors.affiliation: Department of Pharmacology, Dokkyo Medical College, Tochigi, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Ohtani
authors.affiliation: Division of Cardiology, Fujii Masao Memorial Hospital, Kurayosi, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Miyazaki
authors.affiliation: Department of Cardiology, San-in Rosai Hospital, Yonago, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Mizuta
authors.affiliation: Department of Cardiology, San-in Rosai Hospital, Yonago, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Ohtahara
authors.affiliation: Department of Clinical Laboratory, Tottori University Hospital, Yonago Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ogino
authors.affiliation: Division of Regenerative Medicine and Therapeutics, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University, Yonago, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Yoshida
authors.affiliation: Department of Cardiology, Toranomon Hospital, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kuwabara
authors.affiliation: Center for Promoting Next-Generation Highly advanced Medicine, Tottori University Hospital, Yonago, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yoshida
authors.affiliation: Department of Biological Regulation, Tottori University Faculty of Medicine, Yonago, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ninomiya
authors.affiliation: Kotake Cardiology Clinic, Yonago, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kotake
authors.affiliation: Division of Cardiology, Faculty of Medicine Diponegoro University, Semarang, Indonesia.
authors.forename: F
authors.initials: F
authors.lastname: Taufiq
authors.affiliation: Division of Cardiovascular Medicine, Department of Molecular Medicine and Therapeutics, Faculty of Medicine, Tottori University.
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.affiliation: Division of Regenerative Medicine and Therapeutics, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University, Yonago, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Hisatome
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000627:therapeutic use; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D004232:Diuretics / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000379:methods; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D019808:Losartan / Q000627:therapeutic use; D008297:Male; D014527:Uric Acid / Q000097:blood / Q000378:metabolism*
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D004232:Diuretics; D014527:Uric Acid; D003404:Creatinine; D019808:Losartan