title: Brain Food at High Altitude.
abstract: Scenic view at high altitude is a pleasure to the eyes, but it has some shortcoming effects as well. High altitude can be divided into different categories, i.e., high altitude (3000-5000 ft), very high altitude (5000-8000 ft), and extreme altitude (above 8000 ft). Much of the population resides at high altitude, and others go there for tourism. Military personnel are also posted there to defend boundaries. As we ascent to high altitude, partial pressure of oxygen reduces, whereas concentration remains the same; this reduces the availability of oxygen to different body parts. This pathophysiological condition is known as hypobaric hypoxia (HH) which leads to oxidative stress and further causes cognitive dysfunction in some cases. Hypoxia causes neurodegeneration in different brain regions; however, the hippocampus is found to be more prone in comparison to other brain regions. As the hippocampus is affected most, therefore, spatial memory is impaired most during such condition. This chapter will give a brief review of the damaging effect of high altitude on cognition and also throw light on possible herbal interventions at high altitude, which can improve cognitive performance as well as provide protection against the deteriorating effect of hypobaric hypoxia at high altitude.
authors.affiliation: Vallabhbhai Patel Chest Institute, Delhi University, Delhi, 110007, India. vishal6784@gmail.com.
authors.forename: Vishal
authors.initials: V
authors.lastname: Jain
mesh_terms: D000531:Altitude; D000532:Altitude Sickness / Q000517:prevention & control; D000818:Animals; D001921:Brain / Q000187:drug effects*; D006801:Humans; D002534:Hypoxia, Brain / Q000503:physiopathology; D018384:Oxidative Stress / Q000187:drug effects*; D010100:Oxygen / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D017207:Rats, Sprague-Dawley
chemical_list: D010936:Plant Extracts; D010100:Oxygen
keywords: Brain food; Cognition; High altitude; Hypobaric hypoxia; Memory impairment; Nutraceuticals; Oxidative stress