title: Membranous Nephropathy with an Enhanced Granular Expression of Thrombospondin Type-1 Domain-containing 7A in a Pregnant Woman.
abstract: A 30-year-old woman with proteinuria first noted at 26 weeks of gestation was admitted to undergo further evaluation. A renal biopsy revealed membranous nephropathy (MN). There was no evidence of any secondary MN. Prednisolone was initiated 6 months after delivery. Four months later, her urine protein became negative. Enhanced granular staining for thrombospondin type-1 domain-containing 7A (THSD7A) in the glomeruli was retrospectively detected in a biopsy specimen. A literature review revealed that 60% of cases of THSD7A-related MN occurred in women of childbearing age. Therefore, THSD7A-related MN should be considered in female patients presenting with idiopathic MN in childbearing age.
authors.affiliation: First Department of Medicine, Hamamatsu University School of Medicine, Japan.
authors.forename: Takamasa
authors.initials: T
authors.lastname: Iwakura
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Fujigaki
authors.forename: Naoko
authors.initials: N
authors.lastname: Katahashi
authors.forename: Taichi
authors.initials: T
authors.lastname: Sato
authors.forename: Sayaka
authors.initials: S
authors.lastname: Ishigaki
authors.forename: Naoko
authors.initials: N
authors.lastname: Tsuji
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Naito
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Isobe
authors.forename: Masashi
authors.initials: M
authors.lastname: Ono
authors.forename: Yukitoshi
authors.initials: Y
authors.lastname: Sakao
authors.forename: Takayuki
authors.initials: T
authors.lastname: Tsuji
authors.forename: Naro
authors.initials: N
authors.lastname: Ohashi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kato
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Miyajima
authors.forename: Hideo
authors.initials: H
authors.lastname: Yasuda
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003594:Cytoplasmic Granules / Q000378:metabolism; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D007150:Immunohistochemistry; D007678:Kidney Glomerulus / Q000378:metabolism* / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology / Q000378:metabolism*; D011507:Proteinuria / Q000209:etiology / Q000473:pathology*; D019699:Thrombospondins / Q000096:biosynthesis / Q000378:metabolism*; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; C546399:THSD7A protein, human; D019699:Thrombospondins; D011239:Prednisolone