title: Chemotherapeutic agents for GI tumor chemoradiotherapy overview of chemotherapeutic agents to be combined with radiotherapy in the GI tract and their potential as radiosensitizers.
abstract: In the treatment of gastrointestinal tumors, simultaneous radiochemotherapy plays an important role. It is one of the principles of simultaneous radiochemotherapy, applying only chemotherapeutic agents simultaneously to radiation, which are primarily effective in the treated tumor entity, therefore a lot of different agents, like antimetabolites, mostly 5-fluorouracil, platinum derivates (mostly cisplatinum and oxaliplatin), mitomycin C and taxanes are used in simultaneous radiochemotherapy. Most of these have also radiation-intensifying effects. The mechanisms and interactions with ionizing radiation are presented in the article.
authors.affiliation: Clinic for Radiation Oncology, Chemnitz Medical Center, Germany. Electronic address: G.Klautke@skc.de.
authors.forename: G
authors.initials: G
authors.lastname: Klautke
authors.affiliation: Clinic for Radiation Oncology, Chemnitz Medical Center, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Müller
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D059248:Chemoradiotherapy / Q000379:methods*; D005770:Gastrointestinal Neoplasms / Q000628:therapy*; D006801:Humans; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D011838:Radiation-Sensitizing Agents
keywords: Chemoradiotherapy; Gastrointestinal tumors; Mechanism of radiation-intensifying; Radiosensitizers