title: Bronchoscopic Investigation of Atypical Drug-induced Hypersensitivity Syndrome Showing Viral Lung Involvement.
abstract: We herein report a case of atypical drug-induced hypersensitivity syndrome (DIHS) involving serological reactivation of cytomegalovirus induced by carbamazepine with pulmonary and skin manifestations. These lesions were not present on admission, but developed on virus reactivation as indicated by the presence of inclusion bodies and multinucleated giant cells in alveolar cells with CD8(+) T lymphocyte infiltration on a transbronchial lung biopsy. Although the precise mechanism of DIHS remains unknown, this case suggests the crucial role of viral reactivation in pulmonary lesions in DIHS.
authors.affiliation: Department of Respiratory Disease, Southern Tohoku General Hospital, Japan.
authors.forename: Isano
authors.initials: I
authors.lastname: Hase
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Arakawa
authors.forename: Hideo
authors.initials: H
authors.lastname: Sakuma
authors.forename: Fumio
authors.initials: F
authors.lastname: Kaneko
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Koichi
authors.initials: K
authors.lastname: Fujiu
authors.forename: Hideaki
authors.initials: H
authors.lastname: Miyamoto
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Ishii
mesh_terms: D002220:Carbamazepine / Q000009:adverse effects*; D003587:Cytomegalovirus / Q000276:immunology*; D063926:Drug Hypersensitivity Syndrome / Q000503:physiopathology*; D006801:Humans; D008171:Lung Diseases / Q000821:virology*; D008297:Male; D008875:Middle Aged; D014775:Virus Activation / Q000187:drug effects*
chemical_list: D002220:Carbamazepine