title: Pregnancies complicated by preeclampsia and non-preeclampsia-related nephrotic range proteinuria.
abstract: OBJECTIVE
  To examine the impact of nephrotic range proteinuria during pregnancy on renal, maternal and fetal outcomes.
  
  
  METHODS
  A retrospective study of pregnant women with proteinuria greater than 3 g/24 h. Outcome measures included: gestation and mode of delivery, maternal high dependency unit admission, birth weight, maternal blood pressure and proteinuria at time of last follow-up, renal biopsy.
  
  
  RESULTS
  Two hundred and sixty four pregnancies in 262 women were reviewed. Postnatal data were available in 180; of these 104 (57%) had urinary protein quantified postnatally. Sixty three (60%) were pure preeclampsia and nine (9%) super-imposed preeclampsia. Biopsy-proven renal disease was newly diagnosed in nine (9%). Sixty three per cent required caesarean section and 34% required high dependency unit admission. There were no maternal deaths. Birth weight corrected for gestation was below the fifth centile in 33%.
  
  
  CONCLUSIONS
  The incidence of underlying renal pathology in this cohort is significant and highlights the importance of careful follow-up.
authors.affiliation: Royal Liverpool and Broadgreen University Hospitals NHS Trust, UK.
authors.forename: R A
authors.initials: RA
authors.lastname: Brown
authors.affiliation: Institute of Ageing and Chronic Disease, University of Liverpool, UK.
authors.forename: G J
authors.initials: GJ
authors.lastname: Kemp
authors.affiliation: Liverpool Women's NHS Foundation Trust, UK.
authors.forename: S A
authors.initials: SA
authors.lastname: Walkinshaw
authors.affiliation: Royal Liverpool and Broadgreen University Hospitals NHS Trust, UK.
authors.forename: Mlp
authors.initials: M
authors.lastname: Howse
keywords: Nephrology; hypertension; maternal-fetal medicine; pregnancy; proteinuria