title: Fertility and Pregnancy in Turner Syndrome.
abstract: Turner syndrome (TS) occurs in one in 2500 live female births and is one of the most common chromosomal abnormalities in women. Pregnancies in women with TS, conceived with either autologous or donated oocytes, are considered high risk because of the associated miscarriages and life-threatening cardiovascular complications (aortic dissection, severe hypertension). Therefore, it is imperative to conduct a full preconception evaluation and counselling that includes cardiac assessment with Holter blood pressure monitoring, echocardiography, and thoracic MRI. Abnormal findings, such an aortic dilatation, mandate close monitoring throughout the pregnancy and the immediate postpartum period and could possibly contraindicate pregnancy. When in vitro fertilization using donated oocytes is performed in these women, only a single embryo should be transferred. Women with a Turner mosaic karyotype appear to have a lower risk of obstetrical and cardiovascular complications but should nevertheless undergo the full preconception evaluation. In this article, we offer guidelines on the management of women with TS in the preconception period, during pregnancy, and postpartum.
authors.affiliation: Department of Reproductive Medicine, Montreal University Hospital, Montreal QC; Ovo Clinic, Montreal QC.
authors.forename: Pierre-Emmanuel
authors.initials: PE
authors.lastname: Bouet
authors.affiliation: Ovo Clinic, Montreal QC; Department of Endocrinology, Montreal University Hospital, Montreal QC.
authors.forename: Ariane
authors.initials: A
authors.lastname: Godbout
authors.affiliation: Department of Reproductive Medicine, Montreal University Hospital, Montreal QC; Ovo Clinic, Montreal QC.
authors.forename: Hady
authors.initials: H
authors.lastname: El Hachem
authors.affiliation: Ovo Clinic, Montreal QC; Department of Genetics, Montreal University Hospital, Montreal QC.
authors.forename: Maude
authors.initials: M
authors.lastname: Lefebvre
authors.affiliation: Department of Cardiology, Montreal University Hospital, Montreal QC.
authors.forename: Lyne
authors.initials: L
authors.lastname: Bérubé
authors.affiliation: Department of Maternal-Fetal Medicine, Montreal University Hospital, Montreal QC.
authors.forename: Marie-Danielle
authors.initials: MD
authors.lastname: Dionne
authors.affiliation: Department of Reproductive Medicine, Montreal University Hospital, Montreal QC; Ovo Clinic, Montreal QC.
authors.forename: Carole
authors.initials: C
authors.lastname: Kamga-Ngande
authors.affiliation: Department of Reproductive Medicine, Montreal University Hospital, Montreal QC; Ovo Clinic, Montreal QC.
authors.forename: Louise
authors.initials: L
authors.lastname: Lapensée
mesh_terms: D000022:Abortion, Spontaneous; D005260:Female; D005298:Fertility; D059247:Fertility Preservation; D006801:Humans; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000453:epidemiology / Q000628:therapy; D011256:Pregnancy Outcome / Q000453:epidemiology; D018566:Pregnancy, High-Risk; D012307:Risk Factors; D014424:Turner Syndrome / Q000150:complications / Q000453:epidemiology* / Q000628:therapy
keywords: Syndrome de Turner; Turner syndrome; aortic dissection; don d'ovocyte; grossesse; oocyte donation; pregnancy