title: Guillain-Barré Syndrome After Zika Virus Infection in Brazil.
abstract: Zika virus (ZIKV) is an emerging flavivirus, which has caused a widespread outbreak in the Americas. Shortly after its introduction in 2015, a cluster of cases with Guillain-Barré syndrome was detected in Brazil. Herein, we describe two cases from the city of Salvador, who developed ascending paresis after an acute exanthematous illness. The patients were admitted to the intensive care unit with tetraparesis and cranial nerve palsy, which resolved after intravenous administration of human immunoglobulin. Serological evaluation detected IgM-specific ZIKV antibodies. In regions of Zika virus transmission, health-care workers must be aware of the potential severe neurological complications associated with ZIKV infection and be prepared to provide prompt diagnosis, treatment, and supportive care.
authors.affiliation: Hospital Geral Roberto Santos, Secretaria Estadual da Saúde da Bahia, Salvador, Brazil.
authors.forename: Mateus Santana
authors.initials: MS
authors.lastname: do Rosário
authors.affiliation: Hospital Geral Roberto Santos, Secretaria Estadual da Saúde da Bahia, Salvador, Brazil.
authors.forename: Pedro Antonio Pereira
authors.initials: PA
authors.lastname: de Jesus
authors.affiliation: Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas.|Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas.
authors.forename: Nikos
authors.initials: N
authors.lastname: Vasilakis
authors.affiliation: Hospital Geral Roberto Santos, Secretaria Estadual da Saúde da Bahia, Salvador, Brazil.
authors.forename: Daniel Santana
authors.initials: DS
authors.lastname: Farias
authors.affiliation: Hospital São Rafael, Fundação Monte Tabor, Salvador, Brazil.
authors.forename: Marco Antônio Caires
authors.initials: MA
authors.lastname: Novaes
authors.affiliation: Seção de Arbovirologia e Febres Hemorrágicas, Instituto Evandro Chagas/SVS/MS, Ananindeua, Brazil.
authors.forename: Sueli Guerreiro
authors.initials: SG
authors.lastname: Rodrigues
authors.affiliation: Seção de Arbovirologia e Febres Hemorrágicas, Instituto Evandro Chagas/SVS/MS, Ananindeua, Brazil.
authors.forename: Lívia Caricio
authors.initials: LC
authors.lastname: Martins
authors.affiliation: Seção de Arbovirologia e Febres Hemorrágicas, Instituto Evandro Chagas/SVS/MS, Ananindeua, Brazil.
authors.forename: Pedro Fernando da Costa
authors.initials: PF
authors.lastname: Vasconcelos
authors.affiliation: Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut.
authors.forename: Albert Icksang
authors.initials: AI
authors.lastname: Ko
authors.affiliation: Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Ministério da Saúde, Salvador, Brazil.
authors.forename: Luiz Carlos Junior
authors.initials: LC
authors.lastname: Alcântara
authors.affiliation: Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Ministério da Saúde, Salvador, Brazil. isadora.siqueira@bahia.fiocruz.br.
authors.forename: Isadora Cristina
authors.initials: IC
authors.lastname: de Siqueira
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D001938:Brazil / Q000453:epidemiology; D004196:Disease Outbreaks; D005260:Female; D020275:Guillain-Barre Syndrome / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D055815:Young Adult; D000071244:Zika Virus; D000071243:Zika Virus Infection / Q000150:complications / Q000175:diagnosis*
chemical_list: D000914:Antibodies, Viral; D007075:Immunoglobulin M