title: A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase.
abstract: Serine metabolism is likely to play a critical role in cancer cell growth. A recent study reports the identification of a novel small-molecule inhibitor of serine synthesis that targets 3-phosphoglycerate dehydrogenase (PHGDH), the first enzyme of the serine synthesis pathway, and selectively abrogates the proliferation of PHGDH overexpressing breast cancer cells.
authors.affiliation: Meyer Cancer Center, Weill Cornell Medical College, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, New York, NY, USA; Biological and Biomedical Sciences Graduate Program, Harvard Medical School, Boston, MA, USA.
authors.forename: Edouard
authors.initials: E
authors.lastname: Mullarky
authors.affiliation: Department of Chemistry, The Scripps Research Institute, North Torrey Pines, La Jolla, CA, USA; The California Institute for Biomedical Research, North Torrey Pines, La Jolla, CA, USA.
authors.forename: Luke L
authors.initials: LL
authors.lastname: Lairson
authors.affiliation: Meyer Cancer Center, Weill Cornell Medical College, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
authors.forename: Lewis C
authors.initials: LC
authors.lastname: Cantley
authors.affiliation: Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Costas A
authors.initials: CA
authors.lastname: Lyssiotis
keywords: 3-phosphoglycerate dehydrogenase; PHGDH; cancer metabolism; serine