title: [The Mechanism of HLA Class I and PD-L1 Expression of Cancer Cells in Tumor Microenvironment].
abstract: HLA class I and PD-L1expressed on cancer cells play a pivotal role in the CTL recognition mechanism against cancer cells in the tumor microenvironment. It is well known that IFN-g upregulates PD-L1as well as HLA class I expression in cancer cells, and it is suggested that TILs, including CTL, produce IFN-g in the tumor microenvironment. Therefore, there is a possibility that IFN-g produced by activated TILs upregulate both HLA class I and PD-L1expression in cancer cells in the tumor microenvironment. We propose that the anti-tumor effect of CTL could be enhanced if the inhibition of CTL recognition mechanism against cancer cells via the PD-1/PD-L1pathway is canceled by anti-PD-1or anti-PD-L1antibody.
authors.affiliation: Dept. of Surgery, Fujikawa Hospital, Kyonan Medical Center.
authors.forename: Kousaku
authors.initials: K
authors.lastname: Mimura
authors.forename: Kensuke
authors.initials: K
authors.lastname: Shiraishi
authors.forename: Masashi
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kono
authors.forename: Koji
authors.initials: K
authors.lastname: Kono
mesh_terms: D060890:B7-H1 Antigen / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D009369:Neoplasms / Q000276:immunology*; D061026:Programmed Cell Death 1 Receptor / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D059016:Tumor Microenvironment
chemical_list: D060890:B7-H1 Antigen; C423236:CD274 protein, human; D015395:Histocompatibility Antigens Class I; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor