title: Effects of whey protein supplement in the elderly submitted to resistance training: systematic review and meta-analysis.
abstract: OBJECTIVE
  We performed a systematic review to map the evidence and analyze the effect of whey protein supplementation in the elderly submitted to resistance training.
  
  
  METHODS
  A comprehensive search on Medline, LILACS, EMBASE, and the Cochrane Library for relevant publications was conducted until August 2015. The terms used in the search were: "Resistance training"; "Whey protein"; "Elderly".
  
  
  RESULTS
  A total of 632 studies were screened. Five studies were included composing a sample of 391 patients. The supplement whey protein was associated with higher total protein ingestion 9.40 (95% CI: 4.03-14.78), and with an average change in plasma leucine concentration. The supplementation was also associated with increased mixed muscle protein synthesis 1.26 (95% CI: 0.46-2.07) compared to the control group.
  
  
  CONCLUSIONS
  We observed an increase in total protein intake, resulting in increased concentration of leucine and mixed muscle protein fractional synthesis rate.
authors.affiliation: a Graduate Program in Health Sciences, Laboratory of Epidemiology , Universidade do Extremo Sul Catarinense , Criciuma , Brazil.
authors.forename: Tamy
authors.initials: T
authors.lastname: Colonetti
authors.affiliation: b Laboratory of Evidence-based Practice , Universidade do Extremo Sul Catarinense , Criciuma , Brazil.
authors.forename: Antonio Jose
authors.initials: AJ
authors.lastname: Grande
authors.affiliation: c British Heart Foundation Centre on Population Approaches for Non-Communicable Disease Prevention, Nuffield Department of Population Health , University of Oxford , Oxford , UK.
authors.forename: Karen
authors.initials: K
authors.lastname: Milton
authors.affiliation: c British Heart Foundation Centre on Population Approaches for Non-Communicable Disease Prevention, Nuffield Department of Population Health , University of Oxford , Oxford , UK.
authors.forename: Charlie
authors.initials: C
authors.lastname: Foster
authors.affiliation: d Laboratory of Epidemiology , Universidade do Extremo Sul Catarinense , Criciuma , Brazil.
authors.forename: Maria Cecilia Manenti
authors.initials: MC
authors.lastname: Alexandre
authors.affiliation: d Laboratory of Epidemiology , Universidade do Extremo Sul Catarinense , Criciuma , Brazil.
authors.forename: Maria Laura Rodrigues
authors.initials: ML
authors.lastname: Uggioni
authors.affiliation: a Graduate Program in Health Sciences, Laboratory of Epidemiology , Universidade do Extremo Sul Catarinense , Criciuma , Brazil.
authors.forename: Maria Inês da
authors.initials: MI
authors.lastname: Rosa
mesh_terms: D000368:Aged; D016208:Databases, Factual; D019587:Dietary Supplements; D006801:Humans; D009124:Muscle Proteins / Q000096:biosynthesis; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism; D016032:Randomized Controlled Trials as Topic; D055070:Resistance Training; D000067816:Whey Proteins / Q000008:administration & dosage*
chemical_list: D009124:Muscle Proteins; D000067816:Whey Proteins
keywords: Systematic review; elderly; meta-analyses; whey protein