title: Is the incidence of type 1 diabetes in children and adolescents stabilising? The first 6 years of a National Register.
abstract: The Irish Childhood Diabetes National Register (ICDNR) was established in 2008 to define accurately the incidence and monitor the epidemiology of type 1 diabetes (T1D) in the Irish population. Here, we report data from the first 6 years of the National Register and compare with previous national data. Prospective national incident data regarding T1D in those under 15 years resident in Ireland were collected from 2008 to 2013 and national incidence rates (IRs) calculated. Ascertainment completeness was assessed using capture-recapture methodology. The period identified 1566 new cases of T1D, ascertainment reached 96.8 % in 2013. The standardised incidence rate was 27.5 in 2008 stabilising at 28.7 and 28.8 cases /100,000/year in 2012 and 2013. There was no evidence that the incidence changed significantly in the 6-year period either overall or for each age group and gender. There was evidence of a difference in the incidence of T1D across the age groups with the overall incidence highest in the 10-14 year age category. A strong seasonal association was demonstrated.
  
  
  CONCLUSIONS
  This study confirms Ireland as a high-incidence country for type 1 diabetes whilst demonstrating that the previous marked increase in IR from 16.3 cases/100,000/year in 1997 has not continued. Ongoing monitoring through the robust mechanism of the ICDNR is required to clarify whether this is a fluctuation or if the incidence of T1D diabetes has stopped rising in our population. Alternatively, this apparent stabilisation may reflect a shift to a later age at diagnosis. "What is known :" • The incidence of Type 1 diabetes (T1D) is increasing in most populations worldwide although in certain high-incidence populations, it may be stabilising • There was a marked increase in T1D in Ireland between 1997 and 2008 • T1D incidence increases with affluence "What is New:" • The high incidence of T1D in Ireland has been confirmed at 28.8 cases/100,000/year in 2013 and has been effectively stable in the period 2008-2013 • Incidence is highest in Irish 10-14 year olds • Changes in incidence possibly reflecting life style and economic climate • Marked seasonality of diagnosis confirmed.
authors.affiliation: The Department of Paediatric Growth, Diabetes and Endocrinology, National Children's Hospital, Trinity Centre for Health Sciences, Tallaght Hospital, Dublin 24, Ireland. rocheef@tcd.ie.|The Discipline of Paediatrics and Child Health, The University of Dublin, Trinity College Dublin, Dublin, Ireland. rocheef@tcd.ie.
authors.forename: Edna F
authors.initials: EF
authors.lastname: Roche
authors.affiliation: The Discipline of Paediatrics and Child Health, The University of Dublin, Trinity College Dublin, Dublin, Ireland.
authors.forename: Amanda M
authors.initials: AM
authors.lastname: McKenna
authors.affiliation: Information Communication Technology Department, Tallaght Hospital, Dublin, Ireland.
authors.forename: Kerry J
authors.initials: KJ
authors.lastname: Ryder
authors.affiliation: The Department of Paediatric Growth, Diabetes and Endocrinology, National Children's Hospital, Trinity Centre for Health Sciences, Tallaght Hospital, Dublin 24, Ireland.
authors.forename: Adrienne A
authors.initials: AA
authors.lastname: Brennan
authors.affiliation: Department of Statistics, The University of Dublin, Trinity College Dublin, Dublin, Ireland.
authors.forename: Myra
authors.initials: M
authors.lastname: O'Regan
authors.affiliation: The Department of Paediatric Growth, Diabetes and Endocrinology, National Children's Hospital, Trinity Centre for Health Sciences, Tallaght Hospital, Dublin 24, Ireland.|The Discipline of Paediatrics and Child Health, The University of Dublin, Trinity College Dublin, Dublin, Ireland.
authors.forename: Hilary McV
authors.initials: HM
authors.lastname: Hoey
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007494:Ireland / Q000453:epidemiology; D008297:Male; D011446:Prospective Studies; D012042:Registries; D013997:Time Factors
keywords: Children; Epidemiology; Incidence; Ireland; Register; Type 1 diabetes