title: Impact of spillover from white matter by partial volume effect on quantification of amyloid deposition with [11C]PiB PET.
abstract: High non-specific uptake of [11C]Pittsburgh compound B ([11C]PiB) in white matter and signal spillover from white matter, due to partial volume effects, confound radioactivity measured in positron emission tomography (PET) with [11C]PiB. We aimed to reveal the partial volume effect in absolute values of kinetic parameters for [11C]PiB, in terms of spillover from white matter. Dynamic data acquired in [11C]PiB PET scans with five healthy volunteers and eight patients with Alzheimer's disease were corrected with region-based and voxel-based partial volume corrections. Binding potential (BPND) was estimated using the two-tissue compartment model analysis with a plasma input function. Partial volume corrections significantly decreased cortical BPNDvalues. The degree of decrease in healthy volunteers (-52.7±5.8%) was larger than that in Alzheimer's disease patients (-11.9±4.2%). The simulation demonstrated that white matter spillover signals due to the partial volume effect resulted in an overestimation of cortical BPND, with a greater degree of overestimation for lower BPNDvalues. Thus, an overestimation due to partial volume effects is more severe in healthy volunteers than in Alzheimer's disease patients. Partial volume corrections may be useful for accurately quantifying Aβ deposition in cortical regions.
authors.affiliation: Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels, Akita, Japan. Electronic address: matsubara@akita-noken.jp.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Matsubara
authors.affiliation: Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels, Akita, Japan.
authors.forename: Masanobu
authors.initials: M
authors.lastname: Ibaraki
authors.affiliation: Department of Functional Brain Imaging Research (DOFI), National Institute of Radiological Sciences (NIRS), National Institute for Quantum and Radiological Science and Technology (QST), Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Shimada
authors.affiliation: Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences (NIRS), National Institute for Quantum and Radiological Science and Technology (QST), Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Ikoma
authors.affiliation: Department of Functional Brain Imaging Research (DOFI), National Institute of Radiological Sciences (NIRS), National Institute for Quantum and Radiological Science and Technology (QST), Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Suhara
authors.affiliation: Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels, Akita, Japan.
authors.forename: Toshibumi
authors.initials: T
authors.lastname: Kinoshita
authors.affiliation: Department of Functional Brain Imaging Research (DOFI), National Institute of Radiological Sciences (NIRS), National Institute for Quantum and Radiological Science and Technology (QST), Japan; Department of Radiology and Nuclear Medicine, Fukushima Medical University, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ito
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000814:Aniline Compounds; D002250:Carbon Radioisotopes; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D013844:Thiazoles; D066127:White Matter / Q000000981:diagnostic imaging* / Q000378:metabolism*
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D002250:Carbon Radioisotopes; D013844:Thiazoles
keywords: Alzheimer's disease; Amyloid; Compartment model analysis; PET; Partial volume effect