title: Patients without ST elevation after return of spontaneous circulation may benefit from emergent percutaneous intervention: A systematic review and meta-analysis.
abstract: The American Heart Association recommends that post-arrest patients with evidence of ST elevation myocardial infarction (STEMI) on electrocardiogram (ECG) be emergently taken to the catheterization lab for percutaneous coronary intervention (PCI). However, recommendations regarding the utility of emergent PCI for patients without ST elevation are less specific. This review examined the literature on the utility of PCI in post-arrest patients without ST elevation compared to patients with STEMI.
  
  
  
  A systematic review of the English language literature was performed for all years to March 1, 2015 to examine the hypothesis that a percentage of post-cardiac arrest patients without ST elevation will benefit from emergent PCI as defined by evidence of an acute culprit coronary lesion.
  
  
  
  Out of 1067 articles reviewed, 11 articles were identified that allowed for analysis of data to examine our study hypothesis. These studies show that patients presenting post cardiac arrest with STEMI are thirteen times more likely to be emergently taken to the catheterization lab than patients without STEMI; OR 13.8 (95% CI 4.9-39.0). Most importantly, the cumulative data show that when taken to the catheterization lab as much as 32.2% of patients without ST elevation had an acute culprit lesion requiring intervention, compared to 71.9% of patients with STEMI; OR 0.15 (95% CI 0.06-0.34).
  
  
  
  The results of this systematic review demonstrate that nearly one third of patients who have been successfully resuscitated from cardiopulmonary arrest without ST elevation on ECG have an acute lesion that would benefit from emergent percutaneous coronary intervention.
authors.affiliation: Johns Hopkins University School of Medicine, Baltimore, MD, United States. Electronic address: millin@jhmi.edu.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Millin
authors.affiliation: National Study Center for the Study of Trauma and EMS Baltimore, MD, United States. Electronic address: acomer@stapa.umm.edu.
authors.forename: Angela C
authors.initials: AC
authors.lastname: Comer
authors.affiliation: MedStar Georgetown University Hospital, United States. Electronic address: JVNable@gmail.com.
authors.forename: Jose V
authors.initials: JV
authors.lastname: Nable
authors.affiliation: Johns Hopkins University School of Medicine, Baltimore, MD, United States. Electronic address: pjohnst1@jhmi.edu.
authors.forename: Peter V
authors.initials: PV
authors.lastname: Johnston
authors.affiliation: University of Maryland School of Medicine Baltimore, MD, United States. Electronic address: blawn001@umaryland.edu.
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Lawner
authors.affiliation: Johns Hopkins University School of Medicine, Baltimore, MD, United States. Electronic address: nwoltma1@jhmi.edu.
authors.forename: Nathan
authors.initials: N
authors.lastname: Woltman
authors.affiliation: Johns Hopkins University School of Medicine, Baltimore, MD, United States. Electronic address: levy@jhmi.edu.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Levy
authors.affiliation: Maryland Institute for Emergency Medical Services Systems, Baltimore, MD, United States. Electronic address: kseaman@miemss.org.
authors.forename: Kevin G
authors.initials: KG
authors.lastname: Seaman
authors.affiliation: University of Maryland School of Medicine Baltimore, MD, United States. Electronic address: jhirshon@umaryland.edu.
authors.forename: Jon Mark
authors.initials: JM
authors.lastname: Hirshon
mesh_terms: D001775:Blood Circulation / Q000502:physiology; D006328:Cardiac Catheterization; D016887:Cardiopulmonary Resuscitation; D004562:Electrocardiography; D006323:Heart Arrest / Q000209:etiology* / Q000401:mortality / Q000628:therapy; D006760:Hospitalization; D006801:Humans; D062645:Percutaneous Coronary Intervention / Q000706:statistics & numerical data*; D017410:Practice Guidelines as Topic; D000072657:ST Elevation Myocardial Infarction / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D016896:Treatment Outcome
keywords: Cardiopulmonary arrest; Meta-analysis; Percutaneous intervention; Return of spontaneous circulation; Systematic review