title: Assesment of Correlation of Herpes Simplex Virus-1 with Oral Cancer and Precancer- A Comparative Study.
abstract: BACKGROUND
  Most common malignant neoplasm in the oral cavity is squamous cell carcinoma. Herpes simplex virus (HSV) may enhance the development of oral carcinoma in individuals who are already at increased risk of the disease because of tobacco consumption and cigarette smoking and so must be considered as a possible etiologic agent in oral cancer and precancer.
  
  
  OBJECTIVE
  To assess and compare the correlation of HSV-1 in oral cancer and precancerous lesions/conditions with healthy subjects.
  
  
  METHODS
  The study comprised of 150 subjects who were divided into three groups as oral cancer, precancer and control group. Their blood samples were collected and were tested for HSV-1 IgG antibody level, using 'Herpe Select-1' ELISA kit.
  
  
  RESULTS
  There was statistically insignificant difference between the HSV-1 IgG level in cancer and precancer but statistically significant difference was found between the HSV-1 IgG level among control group and cancer/precancer.
  
  
  CONCLUSIONS
  The present study clearly indicates that quantitative estimation of IgG antibody against HSV-1 in cancer/precancer patients will give the clue in the etiology of cancer or precancer. However, further studies with a large sample size should be carried out to determine the role of HSV-1 in etiology of oral cancer and precancer.
authors.affiliation: Senior Lecturer, Department of Oral Medicine and Radiology, Maharana Pratap College of Dentistry & Research Centre , Putli Ghar Road, Gwalior (M.P), India .
authors.forename: Mayuri
authors.initials: M
authors.lastname: Jain
keywords: Immunoglobulin; Neoplasm; Potentially malignant lesion