title: Clinical Association of a Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) in Patients with Systemic Lupus Erythematosus.
abstract: A triggering receptor expressed on myeloid cells-1 (TREM-1) is a member of the immunoglobulin superfamily with an established role in innate and adaptive immune response. We aimed to determine the plasma concentrations and clinical association of sTREM-1 in Systemic Lupus Erythematosus (SLE) patients. Plasma from 79 SLE patients and 35 normal healthy subjects were assayed for sTREM-1 and IL-6 levels using Enzyme Linked Immunosorbant Assay (ELISA). The clinical disease characteristics and serological data were prospectively assessed. Disease activity was scored using the SLE disease activity index. We detected significantly higher levels of sTREM-1 in plasma of SLE patients than the healthy control group. We also detected high sTREM-1 levels in subgroups of patients with neuropsychiatric manifestations (NPLE) and patients with the total high disease activity and NPLE activity. In addition, sTREM-l levels were significantly correlated with parameters of disease activity, i.e. SLEDAI score, IL-6, hypoalbuminemia. On the other hand, we did not find significant differences in sTREM-1 levels in relation to age, disease duration, medications, ESR, other organ system involvement, or the presence of anti-dsDNA. Our preliminary data indicated that sTREM-1 levels may be an additional useful marker of disease activity in SLE. It also highlights its importance in patients with NPLE. An additional prospective longitudinal study should be carried out to support these findings.
authors.affiliation: a Rheumatology and Rehabilitation Department , Faculty of Medicine, Cairo University , Cairo , Egypt.
authors.forename: Iman H
authors.initials: IH
authors.lastname: Bassyouni
authors.affiliation: a Rheumatology and Rehabilitation Department , Faculty of Medicine, Cairo University , Cairo , Egypt.
authors.forename: Samar
authors.initials: S
authors.lastname: Fawzi
authors.affiliation: a Rheumatology and Rehabilitation Department , Faculty of Medicine, Cairo University , Cairo , Egypt.
authors.forename: Tamer A
authors.initials: TA
authors.lastname: Gheita
authors.affiliation: b Medical Microbiology and Immunology Department , Fayoum University , Fayoum , Egypt.
authors.forename: Rasha H
authors.initials: RH
authors.lastname: Bassyouni
authors.affiliation: c Clinical Pathology Department , Faculty of Medicine, Cairo University , Cairo , Egypt.
authors.forename: Aml S
authors.initials: AS
authors.lastname: Nasr
authors.affiliation: d Internal Medicine Department , Division of Rheumatology, Ain Shams University , Cairo , Egypt.
authors.forename: Samah A
authors.initials: SA
authors.lastname: El Bakry
authors.affiliation: d Internal Medicine Department , Division of Rheumatology, Ain Shams University , Cairo , Egypt.
authors.forename: Naglaa
authors.initials: N
authors.lastname: Afifi
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D018450:Disease Progression; D004534:Egypt; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000276:immunology / Q000378:metabolism; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D022423:Myeloid Cells / Q000276:immunology*; D011446:Prospective Studies; D011971:Receptors, Immunologic / Q000097:blood*; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; D055815:Young Adult
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; D002097:C-Reactive Protein
keywords: Neuropsychiatric lupus; systemic lupus erythematosus; triggering receptor expressed on myeloid cells-1