title: Efficacy of resistin and leptin in predicting persistent organ failure in patients with acute pancreatitis.
abstract: BACKGROUND
  To investigate the accuracy of resistin, leptin and adiponectin levels in predicting persistent organ failure in patients with acute pancreatitis (AP).
  
  
  METHODS
  Data from 90 consecutive patients admitted to our hospital for AP were retrospectively collected from an ongoing prospective cohort study. The levels of adiponectin, leptin and resistin were measured and compared between patients with and without persistent organ failure. The accuracy of the adipokines in predicting persistent organ failure were compared with the patients' Acute Physiology and Chronic Health Evaluation II (APACHE-II) score, and were separately investigated in overweight and non-overweight groups.
  
  
  RESULTS
  Persistent organ failure occurred in 26.7% of the patients. The levels of resistin were significantly increased in AP patients with persistent organ failure, in both the overweight and the non-overweight subgroups. Resistin and APACHE-II score predicted persistent organ failure with comparable areas under the curve (AUC) of 0.72 and 0.75, respectively (p = 0.66). Resistin demonstrated similar accuracy with the APACHE-II score in predicting persistent organ failure in the overweight (0.69 vs. 0.66, p = 0.82) and non-overweight (0.76 vs. 0.87, p = 0.39) subgroups. There was no correlation between adiponectin and persistent organ failure, but a weak correlation between leptin and persistent organ failure was demonstrated.
  
  
  CONCLUSIONS
  Resistin and leptin levels, rather than adiponectin, correlate with persistent organ failure in patients with AP.
authors.affiliation: State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, 127 Changle Western Road, Xi'an, Shaanxi, 710032, China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, 127 Changle Western Road, Xi'an, Shaanxi, 710032, China.
authors.forename: Shiqi
authors.initials: S
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, 127 Changle Western Road, Xi'an, Shaanxi, 710032, China; Department of General Surgery, The General Hospital of People' Liberation Army (301 Hospital), 28 Fuxing Road Beijing (wukesong), Beijing, 100853, China.
authors.forename: Zhaoyan
authors.initials: Z
authors.lastname: Qiu
authors.affiliation: State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, 127 Changle Western Road, Xi'an, Shaanxi, 710032, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Bai
authors.affiliation: State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, 127 Changle Western Road, Xi'an, Shaanxi, 710032, China.
authors.forename: Zhanwei
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, 127 Changle Western Road, Xi'an, Shaanxi, 710032, China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Hao
authors.affiliation: State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, 127 Changle Western Road, Xi'an, Shaanxi, 710032, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, 127 Changle Western Road, Xi'an, Shaanxi, 710032, China.
authors.forename: Min
authors.initials: M
authors.lastname: Guo
authors.affiliation: Department of Intensive Care Unit, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, 127 Changle Western Road, Xi'an, Shaanxi, 710032, China.
authors.forename: Xiangying
authors.initials: X
authors.lastname: Feng
authors.affiliation: State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, 127 Changle Western Road, Xi'an, Shaanxi, 710032, China.
authors.forename: Junjie
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Intensive Care Unit, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, 127 Changle Western Road, Xi'an, Shaanxi, 710032, China. Electronic address: fengqx@fmmu.edu.cn.
authors.forename: Quanxin
authors.initials: Q
authors.lastname: Feng
authors.affiliation: State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, 127 Changle Western Road, Xi'an, Shaanxi, 710032, China. Electronic address: zhaoqc@fmmu.edu.cn.
authors.forename: Qingchuan
authors.initials: Q
authors.lastname: Zhao
mesh_terms: D018806:APACHE; D000208:Acute Disease; D054392:Adipokines / Q000097:blood; D052242:Adiponectin / Q000097:blood; D000328:Adult; D015331:Cohort Studies; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D009102:Multiple Organ Failure / Q000097:blood / Q000175:diagnosis* / Q000209:etiology*; D050177:Overweight / Q000097:blood / Q000150:complications; D010195:Pancreatitis / Q000150:complications*; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D052243:Resistin / Q000097:blood*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: C499918:ADIPOQ protein, human; D054392:Adipokines; D052242:Adiponectin; D020738:Leptin; C499624:RETN protein, human; D052243:Resistin
keywords: APACHE-II; Acute pancreatitis; Adiponectin; Leptin; Organ failure; Resistin