title: Evidence for Human Adaptation and Foodborne Transmission of Livestock-Associated Methicillin-Resistant Staphylococcus aureus.
abstract: We investigated the evolution and epidemiology of a novel livestock-associated methicillin-resistant Staphylococcus aureus strain, which colonizes and infects urban-dwelling Danes even without a Danish animal reservoir. Genetic evidence suggests both poultry and human adaptation, with poultry meat implicated as a probable source.
authors.affiliation: Statens Serum Institut, Copenhagen.
authors.forename: Jesper
authors.initials: J
authors.lastname: Larsen
authors.affiliation: Statens Serum Institut, Copenhagen.|Translational Genomics Research Institute, Flagstaff, Arizona.
authors.forename: Marc
authors.initials: M
authors.lastname: Stegger
authors.affiliation: Statens Serum Institut, Copenhagen.|University of Copenhagen, Frederiksberg.
authors.forename: Paal S
authors.initials: PS
authors.lastname: Andersen
authors.affiliation: Statens Serum Institut, Copenhagen.
authors.forename: Andreas
authors.initials: A
authors.lastname: Petersen
authors.affiliation: Statens Serum Institut, Copenhagen.
authors.forename: Anders R
authors.initials: AR
authors.lastname: Larsen
authors.affiliation: University of Copenhagen, Frederiksberg.|Hvidovre Hospital.
authors.forename: Henrik
authors.initials: H
authors.lastname: Westh
authors.affiliation: Technical University of Denmark, Lyngby.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Agersø
authors.affiliation: Federal Institute for Risk Assessment, Berlin.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Fetsch
authors.affiliation: Federal Institute for Risk Assessment, Berlin.
authors.forename: Britta
authors.initials: B
authors.lastname: Kraushaar
authors.affiliation: Federal Institute for Risk Assessment, Berlin.
authors.forename: Annemarie
authors.initials: A
authors.lastname: Käsbohrer
authors.affiliation: Friedrich-Loeffler-Institut, Neustadt-Mariensee.
authors.forename: Andrea T
authors.initials: AT
authors.lastname: Feβler
authors.affiliation: Friedrich-Loeffler-Institut, Neustadt-Mariensee.
authors.forename: Stefan
authors.initials: S
authors.lastname: Schwarz
authors.affiliation: Robert Koch Institut, Wernigerode, Germany.
authors.forename: Christiane
authors.initials: C
authors.lastname: Cuny
authors.affiliation: Robert Koch Institut, Wernigerode, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Witte
authors.affiliation: Ghent University.|Ross University School of Veterinary Medicine, Basseterre, Saint Kitts and Nevis.
authors.forename: Patrick
authors.initials: P
authors.lastname: Butaye
authors.affiliation: Université Libre de Bruxelles, Brussels, Belgium.
authors.forename: Olivier
authors.initials: O
authors.lastname: Denis
authors.affiliation: French Agency for Food, Environmental and Occupational Health and Safety, Lyon.
authors.forename: Marisa
authors.initials: M
authors.lastname: Haenni
authors.affiliation: French Agency for Food, Environmental and Occupational Health and Safety, Lyon.
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Madec
authors.affiliation: French Agency for Food, Environmental and Occupational Health and Safety, Ploufragan, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Jouy
authors.affiliation: Université Claude Bernard Lyon 1.|Hospices Civils de Lyon.
authors.forename: Frederic
authors.initials: F
authors.lastname: Laurent
authors.affiliation: Istituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana.
authors.forename: Antonio
authors.initials: A
authors.lastname: Battisti
authors.affiliation: Istituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana.
authors.forename: Alessia
authors.initials: A
authors.lastname: Franco
authors.affiliation: Istituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana.
authors.forename: Patricia
authors.initials: P
authors.lastname: Alba
authors.affiliation: University of Palermo, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Mammina
authors.affiliation: Istituto Superiore di Sanitá, Rome.
authors.forename: Annalisa
authors.initials: A
authors.lastname: Pantosti
authors.affiliation: Istituto Superiore di Sanitá, Rome.
authors.forename: Monica
authors.initials: M
authors.lastname: Monaco
authors.affiliation: Utrecht University.|Central Veterinary Institute, Lelystad.
authors.forename: Jaap A
authors.initials: JA
authors.lastname: Wagenaar
authors.affiliation: Netherlands Food and Consumer Product Safety Authority, Utrecht.
authors.forename: Enne
authors.initials: E
authors.lastname: de Boer
authors.affiliation: National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
authors.forename: Engeline
authors.initials: E
authors.lastname: van Duijkeren
authors.affiliation: National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
authors.forename: Max
authors.initials: M
authors.lastname: Heck
authors.affiliation: Complutense University of Madrid.
authors.forename: Lucas
authors.initials: L
authors.lastname: Domínguez
authors.affiliation: University of La Rioja, Logroño, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Torres
authors.affiliation: University of La Rioja, Logroño, Spain.
authors.forename: Myriam
authors.initials: M
authors.lastname: Zarazaga
authors.affiliation: Translational Genomics Research Institute, Flagstaff, Arizona.|George Washington University, Washington D.C.
authors.forename: Lance B
authors.initials: LB
authors.lastname: Price
authors.affiliation: Statens Serum Institut, Copenhagen.
authors.forename: Robert L
authors.initials: RL
authors.lastname: Skov
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D004269:DNA, Bacterial / Q000235:genetics; D003718:Denmark; D005260:Female; D005516:Food Microbiology; D005517:Foodborne Diseases / Q000382:microbiology*; D006801:Humans; D007231:Infant, Newborn; D058751:Livestock / Q000382:microbiology*; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000235:genetics*; D008875:Middle Aged; D008907:Mink / Q000382:microbiology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011200:Poultry / Q000382:microbiology; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000382:microbiology / Q000635:transmission / Q000662:veterinary
chemical_list: D004269:DNA, Bacterial
keywords: MRSA; foodborne transmission; host adaptation; livestock; poultry