title: TOR and paradigm change: cell growth is controlled.
abstract: This year marks the 25th anniversary of the discovery of target of rapamycin (TOR), a highly conserved kinase and central controller of cell growth. In this Retrospective, I briefly describe the discovery of TOR and the subsequent elucidation of its cellular role. I place particular emphasis on an article by Barbet et al. from 1996, the first suggesting that TOR controls cell growth in response to nutrients.
authors.affiliation: Biozentrum, University of Basel, 4056 Basel, Switzerland m.hall@unibas.ch.
authors.forename: Michael N
authors.initials: MN
authors.lastname: Hall
mesh_terms: D002453:Cell Cycle; D002455:Cell Division; D049109:Cell Proliferation; D006801:Humans; D015398:Signal Transduction / Q000502:physiology; D020123:Sirolimus; D058570:TOR Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*
chemical_list: D058570:TOR Serine-Threonine Kinases; D020123:Sirolimus