title: Soyamilk fermented with riboflavin-producing Lactobacillus plantarum CRL 2130 reverts and prevents ariboflavinosis in murine models.
abstract: It has been previously shown that Lactobacillus plantarum CRL 2130 is able to produce riboflavin in soyamilk. The aim of the present study was to evaluate the efficiency of this riboflavin-bio-enriched soyamilk to revert and/or prevent the nutritional deficiency of riboflavin using different animal models. When used to supplement the diets of previously depleted animals, it was shown that the growth, riboflavin status and morphology of the small intestines reverted to normal parameters and were similar to animals supplemented with commercial riboflavin. In the prevention model, the same tendency was observed, where animals that received soyamilk fermented with L. plantarum CRL 2130 did not show signs of riboflavin deficiency. This new bio-fortified soya-based product could be used as part of normal diets to provide a more natural alternative to mandatory fortification with riboflavin for the prevention of its deficiency.
authors.affiliation: 1Centro de Referencia para Lactobacilos - Consejo Nacional de Investigaciones Científicas y Técnicas (CERELA-CONICET),Chacabuco 145,4000,Tucumán,Argentina.
authors.forename: M
authors.initials: M
authors.lastname: Juarez Del Valle
authors.affiliation: 1Centro de Referencia para Lactobacilos - Consejo Nacional de Investigaciones Científicas y Técnicas (CERELA-CONICET),Chacabuco 145,4000,Tucumán,Argentina.
authors.forename: J E
authors.initials: JE
authors.lastname: Laiño
authors.affiliation: 1Centro de Referencia para Lactobacilos - Consejo Nacional de Investigaciones Científicas y Técnicas (CERELA-CONICET),Chacabuco 145,4000,Tucumán,Argentina.
authors.forename: A
authors.initials: A
authors.lastname: de Moreno de LeBlanc
authors.affiliation: 1Centro de Referencia para Lactobacilos - Consejo Nacional de Investigaciones Científicas y Técnicas (CERELA-CONICET),Chacabuco 145,4000,Tucumán,Argentina.
authors.forename: G
authors.initials: G
authors.lastname: Savoy de Giori
authors.affiliation: 1Centro de Referencia para Lactobacilos - Consejo Nacional de Investigaciones Científicas y Técnicas (CERELA-CONICET),Chacabuco 145,4000,Tucumán,Argentina.
authors.forename: J G
authors.identifier: http://orcid.org/0000-0002-4634-8630
authors.initials: JG
authors.lastname: LeBlanc
mesh_terms: D000818:Animals; D004032:Diet; D005260:Female; D005285:Fermentation; D048191:Lactiplantibacillus plantarum / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D012256:Riboflavin / Q000008:administration & dosage / Q000096:biosynthesis*; D012257:Riboflavin Deficiency / Q000209:etiology / Q000517:prevention & control*; D041942:Soy Milk / Q000737:chemistry* / Q000378:metabolism
chemical_list: D012256:Riboflavin
keywords:  CD control diet;  DR depleted–repleted;  EGRAC erythrocyte glutathione reductase activation coefficient;  LAB lactic acid bacteria;  RDD riboflavin-deficient diet; Bio-enriched foods; Lactic acid bacteria; Riboflavin; Soyamilk; Vitamin deficiency