title: SMN - A chaperone for nuclear RNP social occasions?
abstract: Survival Motor Neuron (SMN) protein localizes to both the nucleus and the cytoplasm. Cytoplasmic SMN is diffusely localized in large oligomeric complexes with core member proteins, called Gemins. Biochemical and cell biological studies have demonstrated that the SMN complex is required for the cytoplasmic assembly and nuclear transport of Sm-class ribonucleoproteins (RNPs). Nuclear SMN accumulates with spliceosomal small nuclear (sn)RNPs in Cajal bodies, sub-domains involved in multiple facets of snRNP maturation. Thus, the SMN complex forms stable associations with both nuclear and cytoplasmic snRNPs, and plays a critical role in their biogenesis. In this review, we focus on potential functions of the nuclear SMN complex, with particular emphasis on its role within the Cajal body.
authors.affiliation: a Curriculum in Genetics and Molecular Biology , The University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.|b Integrative Program for Biological and Genome Sciences , The University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.
authors.forename: Amanda C
authors.initials: AC
authors.lastname: Raimer
authors.affiliation: a Curriculum in Genetics and Molecular Biology , The University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.|b Integrative Program for Biological and Genome Sciences , The University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.
authors.forename: Kelsey M
authors.initials: KM
authors.lastname: Gray
authors.affiliation: a Curriculum in Genetics and Molecular Biology , The University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.|b Integrative Program for Biological and Genome Sciences , The University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.|c Lineberger Comprehensive Cancer Center , The University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.|d Department of Biology , The University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.|e Department of Genetics , The University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.
authors.forename: A Gregory
authors.initials: AG
authors.lastname: Matera
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D020541:Coiled Bodies / Q000378:metabolism; D004198:Disease Susceptibility; D006801:Humans; D018832:Molecular Chaperones / Q000378:metabolism; D011485:Protein Binding; D021381:Protein Transport; D012342:RNA, Small Nuclear / Q000235:genetics / Q000378:metabolism; D017411:Ribonucleoproteins, Small Nuclear / Q000378:metabolism*; D055532:SMN Complex Proteins / Q000378:metabolism*; D017381:Spliceosomes / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D018832:Molecular Chaperones; D012342:RNA, Small Nuclear; D017411:Ribonucleoproteins, Small Nuclear; D055532:SMN Complex Proteins