title: Evaluation of Psoriasis Genetic Risk Based on Five Susceptibility Markers in a Population from Northern Poland.
abstract: Psoriasis genetic background depends on polygenic and multifactorial mode of inheritance. As in other complex disorders, the estimation of the disease risk based on individual genetic variants is impossible. For this reason, recent investigations have been focused on combinations of known psoriasis susceptibility markers in order to improve the disease risk evaluation. Our aim was to compare psoriasis genetic risk score (GRS) for five susceptibility loci involved in the immunological response (HLA-C, ERAP1, ZAP70) and in the skin barrier function (LCE3, CSTA) between patients with chronic plaque psoriasis (n = 148) and the control group (n = 146). A significantly higher number of predisposing alleles was observed in patients with psoriasis in comparison to healthy individuals (6.1 vs. 5.2, respectively; P = 8.8×10-7). The statistical significance was even more profound when GRS weighted by logarithm odds ratios was evaluated (P = 9.9×10-14). Our results demonstrate the developed panel of five susceptibility loci to be more efficient in predicting psoriasis risk in the Polish population and to possess higher sensitivity and specificity for the disease than any of the markers analyzed separately, including the most informative HLA-C*06 allele.
authors.affiliation: Department of Dermatology, Venereology and Allergology, Medical University of Gdańsk, Gdańsk, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Stawczyk-Macieja
authors.affiliation: Department of Forensic Medicine, Medical University of Gdańsk, Gdańsk, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Rębała
authors.affiliation: Department of Dermatology, Venereology and Allergology, Medical University of Gdańsk, Gdańsk, Poland.
authors.forename: Aneta
authors.initials: A
authors.lastname: Szczerkowska-Dobosz
authors.affiliation: Department of Forensic Medicine, Medical University of Gdańsk, Gdańsk, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Wysocka
authors.affiliation: Department of Forensic Medicine, Medical University of Gdańsk, Gdańsk, Poland.
authors.forename: Lidia
authors.initials: L
authors.lastname: Cybulska
authors.affiliation: Department of Forensic Medicine, Medical University of Gdańsk, Gdańsk, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Kapińska
authors.affiliation: Department of Forensic Medicine, Medical University of Gdańsk, Gdańsk, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Haraś
authors.affiliation: Department of Forensic Medicine, Medical University of Gdańsk, Gdańsk, Poland.
authors.forename: Paulina
authors.initials: P
authors.lastname: Miniszewska
authors.affiliation: Department of Dermatology, Venereology and Allergology, Medical University of Gdańsk, Gdańsk, Poland.
authors.forename: Roman
authors.initials: R
authors.lastname: Nowicki