title: Temporal Development of Gut Microbiota in Triclocarban Exposed Pregnant and Neonatal Rats.
abstract: Alteration of gut microbial colonization process may influence susceptibility of the newborn/infant to infectious and chronic disease. Infectious disease risk leads to widespread use of non-prescription antimicrobials in household products such as Triclocarban (TCC), an antimicrobial compound in personal care products. TCC concentrates in and is transferred through the milk to suckling offspring. TCC exposure during gestation and lactation significantly reduced phylogenetic diversity (PD) among exposed dams and neonates. Among dams using weighted UniFrac distances, TCC induced significant dysbiosis of gut microbiota by gestational day (GD) 18, a trend that continued after delivery. Similarly, an overall restructuring of gut microbiota occurred in neonates. By postnatal day (PND) 12, communities separated based on exposure status and became significantly different at PND 16. The ability of TCC to drive microbial dysbiosis warrants future investigation to evaluate the safety of non-prescription antimicrobial use, including TCC, during critical exposure windows.
authors.affiliation: Department of Public Health, The University of Tennessee, Knoxville, TN 37996, USA.|Comparative and Experimental Medicine, The University of Tennessee, Knoxville, TN 37996, USA.
authors.forename: Rebekah C
authors.initials: RC
authors.lastname: Kennedy
authors.affiliation: Department of Microbiology, The University of Tennessee, Knoxville, TN 37996, USA.
authors.forename: Russell R
authors.initials: RR
authors.lastname: Fling
authors.affiliation: Department of Fish, Wildlife &Conservation Biology, Colorado State University, Fort Collins, CO 80523, USA.|USDA APHIS, National Wildlife Research Center, Fort Collins, CO 80521, USA.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Robeson
authors.affiliation: Department of Animal Science, The University of Tennessee, Knoxville, TN 37996, USA.
authors.forename: Arnold M
authors.initials: AM
authors.lastname: Saxton
authors.affiliation: Department of Biomedical and Diagnostic Sciences, The University of Tennessee, Knoxville, TN 37996, USA.
authors.forename: Robert L
authors.initials: RL
authors.lastname: Donnell
authors.affiliation: Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, CO 80309, USA.
authors.forename: John L
authors.initials: JL
authors.lastname: Darcy
authors.affiliation: Department of Biomedical and Diagnostic Sciences, The University of Tennessee, Knoxville, TN 37996, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Bemis
authors.affiliation: Department of Microbiology, The University of Tennessee, Knoxville, TN 37996, USA.
authors.forename: Jiang
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Nutrition, The University of Tennessee Knoxville, TN 37996, USA.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Public Health, The University of Tennessee, Knoxville, TN 37996, USA.
authors.forename: Jiangang
authors.initials: J
authors.lastname: Chen
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D044822:Biodiversity; D002224:Carbanilides / Q000494:pharmacology*; D005243:Feces / Q000382:microbiology; D005260:Female; D000069196:Gastrointestinal Microbiome; D005865:Gestational Age; D007774:Lactation; D018811:Maternal Exposure; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats
chemical_list: D000891:Anti-Infective Agents, Local; D002224:Carbanilides; C009540:triclocarban