title: Safety and clinical response of intraventricular caspofungin for Scedosporium apiospermum complex central nervous system infection.
abstract: We present a 71-year old woman treated with 14 days of 5 mg intraventricular caspofungin for Scedosporium apiospermum complex meningoencephalitis diagnosed after spinal fusion and instrumentation. Cerebrospinal fluid studies improved during therapy and intraventricular administration was well tolerated. Within weeks of discontinuation, the patient experienced clinical deterioration with disease progression. There are sparse data on the efficacy and safety of administering intraventricular caspofungin. While apparently safe, intraventricular caspofungin was insufficient for disease control in this case.
authors.affiliation: Department of Neurological Surgery, University of Washington School of Medicine, Seattle, WA, USA.
authors.forename: John R
authors.initials: JR
authors.lastname: Williams
authors.affiliation: Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.
authors.forename: Mark W
authors.initials: MW
authors.lastname: Tenforde
authors.affiliation: Department of Pharmacy, Harborview Medical Center, Seattle, WA, USA.
authors.forename: Jeannie D
authors.initials: JD
authors.lastname: Chan
authors.affiliation: Department of Neurological Surgery, University of Washington School of Medicine, Seattle, WA, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Ko
authors.affiliation: Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA; Department of Global Health, University of Washington School of Medicine, Seattle, WA, USA; Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, USA.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Graham
keywords: Caspofungin; Intraventricular; Scedosporium apiospermum; Scedosporium apiospermum complex