title: Serum fetuin B level increased in subjects of nonalcoholic fatty liver disease: a case-control study.
abstract: Fetuin is an endogenous inhibitor of the insulin receptor tyrosine kinase. Recent studies supported the possible role of fetuin B in metabolic diseases. This study is to evaluate the role of serum fetuin B in nonalcoholic fatty liver disease (NAFLD). A hospital-based case-control study of 184 subjects was conducted. Serum level of fetuin B was measured by enzyme-linked immunosorbent assay. The serum level of fetuin B in the control (91.0 ± 36.9 μg/ml) was lower than it in NAFLD (108.7 ± 38.5 μg/ml, P < 0.001). The percentage of NAFLD increased (42.9%, 58.7% and 60.2%; P < 0.001; linear-by-linear association: P < 0.001), as fetuin B concentration elevated in its tertiles, after adjustment of body mass index (BMI). Furthermore, compared with the 1st tertile, the 3rd tertile of fetuin B indicated an association with the presence of NAFLD (adjusted odds ratio = 2.087, 95% confidence interval [1.016 - 3.937], P = 0.023), after controlling age, sex, BMI, diabetes, hypertension and hypertriglyceridemia. Lastly, fetuin B correlated with diastolic blood pressure, serum alanine transaminase and triglycerides, among the controls. It suggested a potential association between serum fetuin B and the presence of NAFLD.
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang Province, China.
authors.forename: Jinzhou
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang Province, China.
authors.forename: Xingyong
authors.initials: X
authors.lastname: Wan
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang Province, China.
authors.forename: Yuming
authors.initials: Y
authors.lastname: Wang
authors.affiliation: The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, 310003, Zhejiang Province, China.
authors.forename: Kefu
authors.initials: K
authors.lastname: Zhu
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang Province, China.
authors.forename: Chunxiao
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang Province, China.
authors.forename: Chaohui
authors.initials: C
authors.lastname: Yu
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang Province, China. ymli.zju@live.com.
authors.forename: Youming
authors.initials: Y
authors.lastname: Li
mesh_terms: D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D060752:Fetuin-B / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood*; D014280:Triglycerides / Q000097:blood
chemical_list: D060752:Fetuin-B; D014280:Triglycerides; D000410:Alanine Transaminase
keywords: case-control; fetuin B; hepatokine; nonalcoholic fatty liver disease