title: MicroRNA-1275 suppresses cell growth, and retards G1/S transition in human nasopharyngeal carcinoma by down-regulation of HOXB5.
abstract: Through analysis of a reported microarray-based high-throughput examination, we found that miR-1275 was significantly down-regulated in nasopharyngeal carcinoma (NPC). While its role and mechanism participated in NPC progression are still little known. Here, we explored the effect of miR-1275 on the progression of NPC. Results demonstrated that miR-1275 was markedly down-regulated in NPC tissues and cell lines. MiR-1275 markedly repressed cell growth as confirmed by CCK8 and colony formation assay, via inhibition of HOXB5 in NPC cell lines. Moreover, miR-1275 suppressed G1/S transition via inhibition of HOXB5. Further, oncogene HOXB5 was evidenced to be a potential target of miR-1275, and its expression was conversely correlated with miR-1275 expression in NPC. Collectively, our study indicated that miR-1275, a tumor suppressor, played a critical effect on NPC progression via inhibition of cell growth, and suppression of G1/S transition by targeting oncogenic HOXB5.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, ZhongNan Hospital, Wuhan University, No.169 Donghu Road, Wuhan, 430071, Hubei, People's Republic of China.
authors.forename: Kai-Yu
authors.initials: KY
authors.lastname: Sun
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, ZhongNan Hospital, Wuhan University, No.169 Donghu Road, Wuhan, 430071, Hubei, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Peng
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, ZhongNan Hospital, Wuhan University, No.169 Donghu Road, Wuhan, 430071, Hubei, People's Republic of China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, ZhongNan Hospital, Wuhan University, No.169 Donghu Road, Wuhan, 430071, Hubei, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, ZhongNan Hospital, Wuhan University, No.169 Donghu Road, Wuhan, 430071, Hubei, People's Republic of China. xhzwhu@sina.com.
authors.forename: Xu-Hong
authors.initials: XH
authors.lastname: Zhou
keywords: HOXB5; Nasopharyngeal carcinoma (NPC); Proliferation; microRNA-1275 (miR-1275)