title: A solitary uterine relapse in T-cell Acute Lymphoblastic Leukaemia: CT features and pathologic correlation.
abstract: T-cell Acute Lymphoblastic Leukemia (T-cell ALL) is a rare haematological neoplasia, that affects children and less commonly adults. Female genital tract and particularly uterus involvement in acute ALL is rare. This report presents the CT features of a 64-year-old woman with uterine relapse of T-cell ALL, occurring 11 months after the diagnosis, as a second, unique relapse of disease. The patient was asymptomatic when a CT examination showed a homogenous thickness of the uterine wall in comparison with the previous CT examination. Histology from biopsy specimens, obtained through hysteroscopy, confirmed T-cell ALL localisation (TdT+, CD10+, CD3c+ and CD2+). The uterus could be a site of relapse in patients suffering from ALL. Even though an MRI examination could better demonstrate the disease in cases of suspected female genital tract involvement by ALL, the comparison of differences between a present and a previous CT examination is sufficient to suspect the diagnosis.
authors.affiliation: Department of Medical, Surgical and Neuro Sciences, Diagnostic Imaging, Azienda Ospedaliera Universitaria Senese, University of Siena, Siena, Italy.
authors.forename: M A
authors.initials: MA
authors.lastname: Mazzei
authors.affiliation: Department of Medical, Surgical and Neuro Sciences, Diagnostic Imaging, Azienda Ospedaliera Universitaria Senese, University of Siena, Siena, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Bettini
authors.affiliation: Department of Medical, Surgical and Neuro Sciences, Diagnostic Imaging, Azienda Ospedaliera Universitaria Senese, University of Siena, Siena, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Pozzessere
authors.affiliation: Department of Medical, Surgical and Neuro Sciences, Diagnostic Imaging, Azienda Ospedaliera Universitaria Senese, University of Siena, Siena, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Guerrini
authors.affiliation: Division of Hematology and Transplants, Azienda Ospedaliera Universitaria Senese, University of Siena, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Defina
authors.affiliation: Department of Medical Biotechnologies, Section of Pathology, Azienda Ospedaliera, Universitaria Senese, University of Siena, Siena, Italy.
authors.forename: M R
authors.initials: MR
authors.lastname: Ambrosio
authors.affiliation: Division of Hematology and Transplants, Azienda Ospedaliera Universitaria Senese, University of Siena, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Aprile
authors.affiliation: Division of Hematology and Transplants, Azienda Ospedaliera Universitaria Senese, University of Siena, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Bocchia
authors.affiliation: Department of Medical, Surgical and Neuro Sciences, Diagnostic Imaging, Azienda Ospedaliera Universitaria Senese, University of Siena, Siena, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Volterrani
mesh_terms: D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D001943:Breast Neoplasms / Q000188:drug therapy; D004253:DNA Nucleotidylexotransferase / Q000032:analysis; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D016130:Immunophenotyping; D017254:Leukemic Infiltration / Q000000981:diagnostic imaging*; D008875:Middle Aged; D016609:Neoplasms, Second Primary; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D013601:T-Lymphocytes / Q000737:chemistry / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014599:Uterus / Q000000981:diagnostic imaging*
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D004253:DNA Nucleotidylexotransferase