title: Postpolymerization Modifications of Alkene-Functional Polycarbonates for the Development of Advanced Materials Biomaterials.
abstract: Functional aliphatic polycarbonates have attracted significant attention as materials for use as biomedical polymers in recent years. The incorporation of pendent functionality offers a facile method of modifying materials postpolymerization, thus enabling functionalities not compatible with ring-opening polymerization (ROP) to be introduced into the polymer. In particular, polycarbonates bearing alkene-terminated functional groups have generated considerable interest as a result of their ease of synthesis, and the wide range of materials that can be obtained by performing simple postpolymerization modifications on this functionality, for example, through radical thiol-ene addition, Michael addition, and epoxidation reactions. This review presents an in-depth appraisal of the methods used to modify alkene-functional polycarbonates postpolymerization, and the diversity of practical applications for which these materials and their derivatives have been used.
authors.affiliation: Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
authors.forename: Anthony W
authors.initials: AW
authors.lastname: Thomas
authors.affiliation: Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Dove
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D011076:Polycarboxylate Cement / Q000737:chemistry*; D058105:Polymerization
chemical_list: D000475:Alkenes; D001672:Biocompatible Materials; D011076:Polycarboxylate Cement; C005506:polycarbonate
keywords: degradable polymers; drug delivery; functional carbonates; postpolymerization modification; tissue scaffolds