title: Porphyrin-Cored Polymer Nanoparticles: Macromolecular Models for Heme Iron Coordination.
abstract: Porphyrin-cored polymer nanoparticles (PCPNs) were synthesized and characterized to investigate their utility as heme protein models. Created using collapsible heme-centered star polymers containing photodimerizable anthracene units, these systems afford model heme cofactors buried within hydrophobic, macromolecular environments. Spectroscopic interrogations demonstrate that PCPNs display redox and ligand-binding reactivity similar to that of native systems and thus are potential candidates for modeling biological heme iron coordination.
authors.affiliation: Department of Chemistry and ‡Materials Science Program, University of New Hampshire , 23 Academic Way, Durham, New Hampshire 03824, United States.
authors.forename: Kyle J
authors.initials: KJ
authors.lastname: Rodriguez
authors.affiliation: Department of Chemistry and ‡Materials Science Program, University of New Hampshire , 23 Academic Way, Durham, New Hampshire 03824, United States.
authors.forename: Ashley M
authors.initials: AM
authors.lastname: Hanlon
authors.affiliation: Department of Chemistry and ‡Materials Science Program, University of New Hampshire , 23 Academic Way, Durham, New Hampshire 03824, United States.
authors.forename: Christopher K
authors.initials: CK
authors.lastname: Lyon
authors.affiliation: Department of Chemistry and ‡Materials Science Program, University of New Hampshire , 23 Academic Way, Durham, New Hampshire 03824, United States.
authors.forename: Justin P
authors.initials: JP
authors.lastname: Cole
authors.affiliation: Department of Chemistry and ‡Materials Science Program, University of New Hampshire , 23 Academic Way, Durham, New Hampshire 03824, United States.
authors.forename: Bryan T
authors.initials: BT
authors.lastname: Tuten
authors.affiliation: Department of Chemistry and ‡Materials Science Program, University of New Hampshire , 23 Academic Way, Durham, New Hampshire 03824, United States.
authors.forename: Christian A
authors.initials: CA
authors.lastname: Tooley
authors.affiliation: Department of Chemistry and ‡Materials Science Program, University of New Hampshire , 23 Academic Way, Durham, New Hampshire 03824, United States.
authors.forename: Erik B
authors.initials: EB
authors.lastname: Berda
authors.affiliation: Department of Chemistry and ‡Materials Science Program, University of New Hampshire , 23 Academic Way, Durham, New Hampshire 03824, United States.
authors.forename: Samuel
authors.initials: S
authors.lastname: Pazicni
mesh_terms: D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D005290:Ferric Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D006418:Heme / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D011166:Porphyrins / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D005290:Ferric Compounds; D011108:Polymers; D011166:Porphyrins; D006418:Heme