title: Systematic review of renal carcinoma prognostic factors.
abstract: OBJECTIVE
  The natural history of renal cell carcinoma is heterogeneous. Some scenarios can be found in terms of clinical presentation, clinical evolution or type of recurrence (local/metastatic). The aim of this publication is to analyze the most important prognostic factors published in the literature.
  
  
  METHODS
  A literature review ob published papers was performed using the Pubmed, from first Motzer's classification published in 1999 to 2015, according to PRISMA declaration. Search was done using the following keywords: kidney neoplasm, kidney cancer, renal cell carcinoma, prognostic factors, mortality, survival and disease progression. Papers were classified according to level of evidence, the number of patients included and the type of study performed.
  
  
  RESULTS
  The evolution in the knowledge of molecular pathways related to renal oncogenesis and the new targeted therapies has left to remain obsolete the old prognostic models. It's necessary to perform a continuous review to actualize nomograms and to adapt them to the new scenarios.
  
  
  CONCLUSIONS
  Is necessary to perform a proper external validation of existing prognostic factors using prospective and multicentric studies to add them into the daily urologist clinical practice.
authors.affiliation: Servicio de Urología, Hospital de la Vall d'Hebron, Universidad Autonoma de Barcelona, Barcelona, España.
authors.forename: D
authors.initials: D
authors.lastname: Lorente
authors.affiliation: Servicio de Urología, Hospital de la Vall d'Hebron, Universidad Autonoma de Barcelona, Barcelona, España. Electronic address: enriquetrilla@gmail.com.
authors.forename: E
authors.initials: E
authors.lastname: Trilla
authors.affiliation: Unidad de fisiología y fisiopatología renal (VHIR), Barcelona, España.
authors.forename: A
authors.initials: A
authors.lastname: Meseguer
authors.affiliation: Servicio de Urología, Hospital de la Vall d'Hebron, Universidad Autonoma de Barcelona, Barcelona, España.
authors.forename: J
authors.initials: J
authors.lastname: Planas
authors.affiliation: Servicio de Urología, Hospital de la Vall d'Hebron, Universidad Autonoma de Barcelona, Barcelona, España.
authors.forename: J
authors.initials: J
authors.lastname: Placer
authors.affiliation: Servicio de Urología, Hospital de la Vall d'Hebron, Universidad Autonoma de Barcelona, Barcelona, España.
authors.forename: A
authors.initials: A
authors.lastname: Celma
authors.affiliation: Servicio de Urología, Hospital de la Vall d'Hebron, Universidad Autonoma de Barcelona, Barcelona, España.
authors.forename: C
authors.initials: C
authors.lastname: Salvador
authors.affiliation: Servicio de Urología, Hospital de la Vall d'Hebron, Universidad Autonoma de Barcelona, Barcelona, España.
authors.forename: L
authors.initials: L
authors.lastname: Regis
authors.affiliation: Servicio de Urología, Hospital de la Vall d'Hebron, Universidad Autonoma de Barcelona, Barcelona, España.
authors.forename: J
authors.initials: J
authors.lastname: Morote
mesh_terms: D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000401:mortality; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000401:mortality; D011379:Prognosis; D015996:Survival Rate
keywords: Carcinoma renal; Factores pronósticos; Nomogram; Nomograma; Prognostic factors; Renal cell Carcinoma