title: Hemochromatosis: a model of metal-related human toxicosis.
abstract: Many environmental agents, such as excessive alcohol intake, xenobiotics, and virus, are able to damage the human body, targeting especially the liver. Metal excess may also assault the liver. Thus, chronic iron overload may cause, especially when associated with cofactors, diffuse organ damage that is a source of significant morbidity and mortality. Iron excess can be either of acquired (mostly transfusional) or of genetic origin. Hemochromatosis is the archetype of genetic iron overload diseases and represents a serious health problem. A better understanding of iron metabolism has deeply modified the hemochromatosis field which today benefits from much more efficient diagnostic and therapeutic approaches.
authors.affiliation: Hepatology, Faculty of Medicine, University of Rennes1, 2, avenue Pr. Léon BERNARD, 35043, Rennes, France. pierre.brissot@univ-rennes1.fr.|Department of Biochemistry, Pontchaillou University Hospital, Rennes, France. pierre.brissot@univ-rennes1.fr.|Inserm-UMR 991, University of Rennes1, Rennes, France. pierre.brissot@univ-rennes1.fr.
authors.forename: Pierre
authors.initials: P
authors.lastname: Brissot
authors.affiliation: Department of Biochemistry, Pontchaillou University Hospital, Rennes, France.|Inserm-UMR 991, University of Rennes1, Rennes, France.
authors.forename: Thibault
authors.initials: T
authors.lastname: Cavey
authors.affiliation: Department of Biochemistry, Pontchaillou University Hospital, Rennes, France.|Inserm-UMR 991, University of Rennes1, Rennes, France.
authors.forename: Martine
authors.initials: M
authors.lastname: Ropert
authors.affiliation: Inserm-UMR 991, University of Rennes1, Rennes, France.
authors.forename: François
authors.initials: F
authors.lastname: Gaboriau
authors.affiliation: Inserm-UMR 991, University of Rennes1, Rennes, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Loréal
mesh_terms: D006432:Hemochromatosis / Q000139:chemically induced* / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000378:metabolism / Q000633:toxicity*; D019190:Iron Overload; D008099:Liver / Q000187:drug effects / Q000378:metabolism
chemical_list: D007501:Iron
keywords: Ferroportin; Hepcidin; Iron chelation; Iron overload; Labile plasma iron; Lipid peroxidation; Liver fibrosis; Non-transferrin bound iron; Reactive oxygen species; Tumorogenesis; Venesection