title: In vivo anti-Trichophyton Activities of Seed Oil Obtained from Caraganakorshinskii Kom.
abstract: OBJECTIVE
  The objective of this study was to evaluate the effects of seed oil of Caragana korshinskii Kom. against Trichophyton mentagrophytes on an in vivo guinea pig model of dermatophytosis.
  
  
  METHODS
  The skin of albino guinea pigs was infected with T. mentagrophytes, and the animals were divided into five groups: negative control (NC group), positive control (PC group), vehicle control, CK50% group (received topical 50% seed oil of C.korshinskii), and CK100% group (received topical 100% seed oil of C.korshinskii). Evaluation of clinical efficacy was performed 72 h after the completion of a 10-day treatment regimen. Skin biopsy samples were processed for histopathological examination.
  
  
  RESULTS
  The infected untreated control guinea pigs showed patches of hair loss and ulcerated or scaly skin. Lower clinical scores indicate improved efficacy compared with NC. The lesion scores significantly declined in the CK50%, CK100%, and PC groups in comparison with the NC group. The CK50% group (45.31%) and the CK100% group (75%) showed clinical efficacy compared with the PC group (78.13%). In addition, no fungal elements, inflammation, or tissue destruction was observed in any of the PAS-stained sections of the infected skin in the groups treated with CK100% or 1% terbinafine.
  
  
  CONCLUSIONS
  Seed oil of C.korshinskii demonstrated high antifungal efficacy in experimental dermatophytosis.
authors.affiliation: Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, China.
authors.forename: Wenna
authors.initials: W
authors.lastname: Zhou
authors.forename: Heng
authors.initials: H
authors.lastname: Xu
authors.forename: Guangxiang
authors.initials: G
authors.lastname: Luan
authors.forename: HongLun
authors.initials: H
authors.lastname: Wang
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Wang
authors.forename: Mingkai
authors.initials: M
authors.lastname: Ji
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D032602:Caragana; D006168:Guinea Pigs; D008297:Male; D008517:Phytotherapy; D010938:Plant Oils / Q000627:therapeutic use*; D012639:Seeds; D012867:Skin / Q000187:drug effects / Q000473:pathology; D014005:Tinea / Q000188:drug therapy* / Q000473:pathology; D014249:Trichophyton
chemical_list: D000935:Antifungal Agents; D010938:Plant Oils