title: Takotsubo Syndrome-Scientific Basis for Current Treatment Strategies.
abstract: Takotsubo syndrome (TS) is characterized by severe reversible left ventricular (LV) wall motion abnormality in the absence of explanatory coronary lesion. Despite an increasing number of patients diagnosed with TS worldwide, there are no randomized clinical trials. In mild cases, no treatment or a short course of limited anticoagulation therapy may be sufficient. Positive inotropic and vasodilating agents should be avoided. In severe cases with refractory cardiogenic shock, early treatment with mechanical support using venoarterial extracorporeal membrane oxygenation or a LV assist device should be considered.
authors.affiliation: Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Bruna stråket 16, Gothenburg, Sweden; Department of Cardiology, Sahlgrenska University Hospital, Bruna stråket 16, Gothenburg 413 45, Sweden. Electronic address: elmir@wlab.gu.se.
authors.forename: Elmir
authors.initials: E
authors.lastname: Omerovic
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D006348:Cardiac Surgical Procedures / Q000295:instrumentation; D019468:Disease Management; D015199:Extracorporeal Membrane Oxygenation; D006353:Heart-Assist Devices; D006801:Humans; D012770:Shock, Cardiogenic / Q000628:therapy*; D054549:Takotsubo Cardiomyopathy / Q000517:prevention & control / Q000628:therapy*
chemical_list: D000925:Anticoagulants
keywords: Complications; Coronary syndrome; Left ventricular assist device; Takotsubo syndrome