title: Gamma-glutamyltransferase as novel biomarker in patients with uterine leiomyosarcoma.
abstract: Gamma-glutamyltransferase (GGT) is an established marker for proliferative/apoptotic balance and has been associated with cancer risk and prognosis. The aim of this study was to evaluate the value of pre-treatment GGT serum levels as prognostic biomarker in patients with primary uterine leiomyosarcoma (ULMS). Data of women with ULMS were extracted from a multi-center database. Pre-treatment GGT serum levels were measured and patients assigned to predefined GGT risk groups. GGT values were correlated with clinico-pathological parameters and univariate and multivariable survival analyses were performed. A total of 44 patients with ULMS were analyzed. Mean (SD) pre-therapeutic GGT serum level was 33.8 (39.8) U/L. In Figo Stage I versus II-IV mean (SD) GGT values were 28.8 (34.0) U/l and 43.5 (49.2) U/l, respectively (p = 0.25). Five-year overall survival (OS) rates in ULMS patients with normal low versus higher GGT levels were 70% and 37%, respectively (p = 0.043). Univariate and multivariable analyses revealed that higher GGT serum levels (p = 0.043, p = 0.005) and high histological grade (p = 0.029, p = 0.012) were independently associated with impaired OS, respectively. Higher pre-treatment GGT serum levels were independently associated with unfavorable prognosis in women with ULMS. Thus, GGT seems to be a useful novel biomarker in ULMS.
authors.affiliation: Department of General Gynaecology and Gynaecological Oncology, Gynecologic Cancer Unit - Comprehensive Cancer Center, Medical University of Vienna, Vienna,1090, Austria.
authors.forename: Richard
authors.initials: R
authors.lastname: Schwameis
authors.affiliation: Department of General Gynaecology and Gynaecological Oncology, Gynecologic Cancer Unit - Comprehensive Cancer Center, Medical University of Vienna, Vienna,1090, Austria.
authors.forename: Christoph
authors.initials: C
authors.lastname: Grimm
authors.affiliation: Clinical Division of Oncology, Department of Medicine 1, Comprehensive Cancer Center - Medical University Vienna, Vienna, 1090, Austria.
authors.forename: Thomas
authors.initials: T
authors.lastname: Brodowicz
authors.affiliation: Department of Obstetrics and Gynaecology of the Medical University of Graz, Graz, 8036, Austria.
authors.forename: Edgar
authors.initials: E
authors.lastname: Petru
authors.affiliation: Department of Internal Medicine I, Barmherzige Schwestern Hospital Linz, Linz, 4020, Austria.
authors.forename: Katrin
authors.initials: K
authors.lastname: Hefler-Frischmuth
authors.affiliation: Department of Gynaecology, Barmherzige Schwestern Hospital Linz, Linz, 4020, Austria.
authors.forename: Christine
authors.initials: C
authors.lastname: Staudigl
authors.affiliation: Department of General Gynaecology and Gynaecological Oncology, Gynecologic Cancer Unit - Comprehensive Cancer Center, Medical University of Vienna, Vienna,1090, Austria.|Karl Landsteiner Institute for General Gynecology and Experimental Gynecologic Oncology, Vienna,1090, Austria.
authors.forename: Alexander
authors.initials: A
authors.lastname: Reinthaller
authors.affiliation: Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, 1090, Austria.
authors.forename: Georg
authors.initials: G
authors.lastname: Heinze
authors.affiliation: Department of General Gynaecology and Gynaecological Oncology, Gynecologic Cancer Unit - Comprehensive Cancer Center, Medical University of Vienna, Vienna,1090, Austria.|Karl Landsteiner Institute for General Gynecology and Experimental Gynecologic Oncology, Vienna,1090, Austria.
authors.forename: Stephan
authors.initials: S
authors.lastname: Polterauer
authors.affiliation: Department of General Gynaecology and Gynaecological Oncology, Gynecologic Cancer Unit - Comprehensive Cancer Center, Medical University of Vienna, Vienna,1090, Austria.
authors.forename: Mariella
authors.initials: M
authors.lastname: Polterauer
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D016208:Databases, Factual; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000097:blood / Q000401:mortality; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D015996:Survival Rate; D014594:Uterine Neoplasms / Q000097:blood / Q000401:mortality; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D005723:gamma-Glutamyltransferase; C554782:gamma-glutamyltransferase, human