title: Rim15 and Sch9 kinases are involved in induction of autophagic degradation of ribosomes in budding yeast.
abstract: Autophagic degradation of ribosomes is promoted by nutrient starvation and inactivation of target of rapamycin complex 1 (TORC1). Here we show that selective autophagic degradation of ribosomes (called ribophagy) after TORC1 inactivation requires the specific autophagy receptor Atg11. Rim15 protein kinase upregulated ribophagy, while it downregulated non-selective degradation of ribosomes.
authors.affiliation: a Graduate School of Science and Technology , Shizuoka University , Shizuoka , Japan.
authors.forename: Talukdar Muhammad
authors.initials: TM
authors.lastname: Waliullah
authors.affiliation: a Graduate School of Science and Technology , Shizuoka University , Shizuoka , Japan.
authors.forename: Akter Mst
authors.initials: AM
authors.lastname: Yeasmin
authors.affiliation: b Department of Science, Graduate School of Integrated Science and Technology , Shizuoka University , Shizuoka , Japan.
authors.forename: Atsuki
authors.initials: A
authors.lastname: Kaneko
authors.affiliation: b Department of Science, Graduate School of Integrated Science and Technology , Shizuoka University , Shizuoka , Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Koike
authors.affiliation: c Faculty of Science , Shizuoka University , Shizuoka , Japan.
authors.forename: Mashu
authors.initials: M
authors.lastname: Terasawa
authors.affiliation: c Faculty of Science , Shizuoka University , Shizuoka , Japan.
authors.forename: Takaya
authors.initials: T
authors.lastname: Totsuka
authors.affiliation: a Graduate School of Science and Technology , Shizuoka University , Shizuoka , Japan.|b Department of Science, Graduate School of Integrated Science and Technology , Shizuoka University , Shizuoka , Japan.|c Faculty of Science , Shizuoka University , Shizuoka , Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ushimaru
mesh_terms: D001343:Autophagy; D000071183:Autophagy-Related Proteins / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism*; D012270:Ribosomes / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000201:enzymology* / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D033921:Vesicular Transport Proteins / Q000378:metabolism
chemical_list: C502923:Atg11 protein, S cerevisiae; D000071183:Autophagy-Related Proteins; D029701:Saccharomyces cerevisiae Proteins; D033921:Vesicular Transport Proteins; D011494:Protein Kinases; C410736:Rim15 protein, S cerevisiae; C071569:SCH9 protein kinase
keywords: Rim15; Saccharomyces cerevisiae; ribophagy; target of rapamycin complex 1 (TORC1)