title: Intracranial Cystic Myofibroblastoma: a Case Report with Literature Review.
abstract: BACKGROUND
  Myofibroblastoma is a rare benign soft tissue tumor comprised of contractile myiod cells mostly in mammary gland. Only 4 prior cases arising in the central nervous system have been reported in the literature. We present a case of myofibroblastoma with a cystic component.
  
  
  METHODS
  The patient is a 76-year-old man with a history of Parkinson disease. The tumor was found incidentally after a minor fall. Magnetic resonance imaging revealed a 6.7-cm well-circumscribed, partly cystic mass with a 2.4-cm calcified central nodule located at the left sylvian fissure. The frontal dural base showed avid enhancing after gadolinium injection. Gross total resection was achieved. The tumor was marked by dense collagenous tissue and bland spindled cells in pathology review. The spindled cells demonstrated positive staining with antibodies to CD34, estrogen receptor, and smooth muscle actin. A blush of immunoreactivity is observed in scattered cells with antibody to progesterone receptor. Patient recovered well postoperatively.
  
  
  CONCLUSIONS
  This is a rare condition of a benign soft tissue tumor of mammary gland presented primarily in the brain. The literature on myofibroblastomas arising in the central nervous system is reviewed.
authors.affiliation: Department of Neurological Surgery, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.
authors.forename: Saksith
authors.initials: S
authors.lastname: Smithason
authors.affiliation: Department of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio, USA.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Prayson
authors.affiliation: Department of Neurological Surgery, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.
authors.forename: Jeffry P
authors.initials: JP
authors.lastname: Mullin
authors.affiliation: Department of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio, USA.
authors.forename: J Jordi
authors.initials: JJ
authors.lastname: Rowe
authors.affiliation: Department of Neurological Surgery, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA. Electronic address: mohamma3@ccf.org.
authors.forename: Alireza M
authors.initials: AM
authors.lastname: Mohammadi
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001921:Brain / Q000473:pathology / Q000601:surgery; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D002114:Calcinosis / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D020863:Central Nervous System Cysts / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D033162:Incidental Findings; D008279:Magnetic Resonance Imaging; D008297:Male; D008866:Microsurgery; D009379:Neoplasms, Muscle Tissue / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D011183:Postoperative Complications / Q000175:diagnosis
chemical_list: D014408:Biomarkers, Tumor
keywords: Cystic intracranial tumor; Myofibroblastoma; Uncommon pathology