title: CD163 promotes hematoma absorption and improves neurological functions in patients with intracerebral hemorrhage.
abstract: Clinical outcomes are positively associated with hematoma absorption. The monocyte-macrophage scavenger receptor, CD163, plays an important role in the metabolism of hemoglobin, and a soluble form of CD163 is present in plasma and other tissue fluids; therefore, we speculated that serum CD163 affects hematoma absorption after intracerebral hemorrhage. Patients with intracerebral hemorrhage were divided into high- and low-level groups according to the average CD163 level (1,977.79 ± 832.91 ng/mL). Compared with the high-level group, the low-level group had a significantly slower hematoma absorption rate, and significantly increased National Institutes of Health Stroke Scale scores and modified Rankin Scale scores. These results suggest that CD163 promotes hematoma absorption and the recovery of neurological function in patients with intracerebral hemorrhage.
authors.affiliation: Department of Neurology and Neuroscience Center, First Hospital of Jilin University, Changchun, Jilin Province, China.
authors.forename: Wen-Jing
authors.initials: WJ
authors.lastname: Xie
authors.affiliation: Department of Neurosurgery, First Hospital of Jilin University, Changchun, Jilin Province, China.
authors.forename: Hong-Quan
authors.initials: HQ
authors.lastname: Yu
authors.affiliation: Department of Neurosurgery, First Hospital of Jilin University, Changchun, Jilin Province, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Neurology and Neuroscience Center, First Hospital of Jilin University, Changchun, Jilin Province, China.
authors.forename: Qun
authors.identifier: 0000-0001-6914-8351
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Neurology and Neuroscience Center, First Hospital of Jilin University, Changchun, Jilin Province, China.
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Meng
keywords: CD163; absorption; adult; brain; brain injury; haptoglobin; hematoma; hemoglobin; hemoglobin scavenging; intracerebral hemorrhage; nerve regeneration; neural regeneration; soluble CD163