title: Cajal bodies and snRNPs - friends with benefits.
abstract: Spliceosomal snRNPs are complex particles that proceed through a fascinating maturation pathway. Several steps of this pathway are closely linked to nuclear non-membrane structures called Cajal bodies. In this review, I summarize the last 20 y of research in this field. I primarily focus on snRNP biogenesis, specifically on the steps that involve Cajal bodies. I also evaluate the contribution of the Cajal body in snRNP quality control and discuss the role of snRNPs in Cajal body formation.
authors.affiliation: a Institute of Molecular Genetics, Czech Academy of Sciences , Prague , Czech Republic.
authors.forename: David
authors.identifier: 0000-0002-5865-175X
authors.initials: D
authors.lastname: Staněk
mesh_terms: D000818:Animals; D020541:Coiled Bodies / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding; D012323:RNA Processing, Post-Transcriptional; D017411:Ribonucleoproteins, Small Nuclear / Q000235:genetics / Q000378:metabolism*; D017381:Spliceosomes; D014158:Transcription, Genetic
chemical_list: D017411:Ribonucleoproteins, Small Nuclear