title: Oncological Safety of Lipofilling in Patients with Breast Cancer: A Meta-analysis and Update on Clinical Practice.
abstract: Lipofilling is an increasingly popular technique for breast reconstruction following both mastectomy and breast-conserving surgery (BCS). However, concerns remain over its oncological safety and its effect on cancer recurrence.
  
  
  
  A systematic literature review and meta-analysis was carried out. Patients who had undergone mastectomy or BCS were investigated separately in order to find out whether the addition of lipofilling had a significant effect on locoregional recurrence rate.
  
  
  
  Eleven studies were used in the analysis, yielding a total of 2,382 patients. For patients undergoing mastectomy (mean follow-up=36.2 months, range=12-90 months) or BCS (mean follow-up=30.2 months, range=12-60 months), the addition of lipofilling was not found to significantly affect the locoregional recurrence rate.
  
  
  
  This meta-analysis demonstrates that lipofilling is an oncologically safe procedure to be incorporated into breast reconstruction following either mastectomy or BCS for breast cancer. However, a careful oncological follow-up is recommended. In the future, more adequately powered controlled clinical trials are needed in order to fully understand long-term outcomes after lipofilling.
authors.affiliation: The London Breast Institute, The Princess Grace Hospital, London, U.K.
authors.forename: Umar
authors.initials: U
authors.lastname: Wazir
authors.affiliation: The London Breast Institute, The Princess Grace Hospital, London, U.K.
authors.forename: Hiba
authors.initials: H
authors.lastname: El Hage Chehade
authors.affiliation: The London Breast Institute, The Princess Grace Hospital, London, U.K.
authors.forename: Hannah
authors.initials: H
authors.lastname: Headon
authors.affiliation: Kuwait Cancer Control Centre, Al Sabah Medical District, Shuwaikh, Kuwait.
authors.forename: Medhat
authors.initials: M
authors.lastname: Oteifa
authors.affiliation: The London Breast Institute, The Princess Grace Hospital, London, U.K.
authors.forename: Abdul
authors.initials: A
authors.lastname: Kasem
authors.affiliation: The London Breast Institute, The Princess Grace Hospital, London, U.K. kefahmokbel@hotmail.com.
authors.forename: Kefah
authors.initials: K
authors.lastname: Mokbel
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation*; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016462:Mammaplasty / Q000379:methods*; D008408:Mastectomy / Q000379:methods; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D061214:Patient Safety; D012044:Regression Analysis
keywords: Mammaplasty; breast neoplasms; breast reconstruction; lipomodelling; meta-analysis; transplantation