title: Urinary bisphenol-A, phthalate metabolites and body composition in US adults, NHANES 1999-2006.
abstract: BACKGROUND
  Exposure to bisphenol-A (BPA) and phthalates is highly prevalent. Prior studies have not assessed associations between urinary levels of BPA and phthalate metabolites and body composition.
  
  
  METHODS
  National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2006 on adults aged ≥20 were analyzed by linear regression for associations between urinary BPA, monoethyl phthalate, monobutyl phthalate (MBP), monoethylhexyl phthalate (MEHP), and monobenzyl phthalate (MBzP) and lean mass, fat mass, and percent body fat.
  
  
  RESULTS
  BPA and phthalate metabolites were not independently associated with fat mass or percent body fat. Significant inverse associations were observed with lean mass, with the strongest association observed for BPA in men (mean lean mass 1.39 kg lower for quartile 4 vs. quartile 1, p trend = 0.02).
  
  
  CONCLUSIONS
  BPA and some phthalates could have important, negative effects on muscle and may affect conditions related to deficits in lean mass, though additional research is needed.
authors.affiliation: a Department of Biostatistics and Epidemiology , University of Massachusetts Amherst , Amherst , MA , USA.
authors.forename: Iris
authors.initials: I
authors.lastname: Corbasson
authors.affiliation: a Department of Biostatistics and Epidemiology , University of Massachusetts Amherst , Amherst , MA , USA.
authors.forename: Susan E
authors.initials: SE
authors.lastname: Hankinson
authors.affiliation: a Department of Biostatistics and Epidemiology , University of Massachusetts Amherst , Amherst , MA , USA.
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Stanek
authors.affiliation: a Department of Biostatistics and Epidemiology , University of Massachusetts Amherst , Amherst , MA , USA.
authors.forename: Katherine W
authors.initials: KW
authors.lastname: Reeves
mesh_terms: D015502:Absorptiometry, Photon; D001559:Benzhydryl Compounds / Q000652:urine*; D001823:Body Composition; D003430:Cross-Sectional Studies; D004781:Environmental Exposure; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000652:urine*; D009749:Nutrition Surveys; D010636:Phenols / Q000652:urine*; D010795:Phthalic Acids / Q000652:urine*; D014481:United States; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004785:Environmental Pollutants; D010636:Phenols; D010795:Phthalic Acids; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Bisphenol-A; body fat; fat mass; lean mass; phthalates