title: Maternal and Neonatal Morbidity for Women Who Would Be Added to the Diagnosis of GDM Using IADPSG Criteria: A Secondary Analysis of the Hyperglycemia and Adverse Pregnancy Outcome Study.
abstract: To assess the frequency of adverse outcomes for women who are diagnosed with gestational diabetes mellitus (GDM) by the International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria using data from the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study.
  
  
  
  This is a secondary analysis from the North American HAPO study centers. Glucose measurements from a 75-g oral glucose tolerance test were used to group participants into three nonoverlapping categories: GDM based on Carpenter-Coustan (CC) criteria (also GDM based on IADPSG criteria), GDM diagnosed based on IADPSG criteria but not CC criteria, and no GDM. Newborn outcomes included birth weight, cord C-peptide, and newborn percentage fat above the 90th percentile; maternal outcomes included primary cesarean delivery and preeclampsia. Outcome frequencies were compared using multiple logistic regression, adjusting for predefined covariates.
  
  
  
  Among 25,505 HAPO study participants, 6,159 blinded participants from North American centers were included. Of these, 81% had normal glucose testing, 4.2% had GDM based on CC criteria, and 14.3% had GDM based on IADPSG criteria but not CC criteria. Compared with women with no GDM, those diagnosed with GDM based on IADPSG criteria had adjusted odds ratios (95% CIs) for birth weight, cord C-peptide, and newborn percentage fat above the 90th percentile, as well as primary cesarean delivery and preeclampsia, of 1.87 (1.50-2.34), 2.00 (1.54-2.58), 1.73 (1.35-2.23), 1.31 (1.07-1.60), and 1.73 (1.32-2.27), respectively.
  
  
  
  Women diagnosed with GDM based on IADPSG criteria had higher adverse outcome frequencies compared with women with no GDM. These data underscore the need for research to assess the effect of treatment to improve outcomes in such women.
authors.affiliation: Department of Obstetrics and Gynecology, Loyola University Medical Center, Maywood, IL tedwatersmd@gmail.com.
authors.forename: Thaddeus P
authors.initials: TP
authors.lastname: Waters
authors.affiliation: Northwestern University Feinberg School of Medicine, Chicago, IL.
authors.forename: Alan R
authors.initials: AR
authors.lastname: Dyer
authors.affiliation: Northwestern University Feinberg School of Medicine, Chicago, IL.
authors.forename: Denise M
authors.initials: DM
authors.lastname: Scholtens
authors.affiliation: Northwestern University Feinberg School of Medicine, Chicago, IL.
authors.forename: Sharon L
authors.initials: SL
authors.lastname: Dooley
authors.affiliation: Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
authors.forename: Elaine
authors.initials: E
authors.lastname: Herer
authors.affiliation: Northwestern University Feinberg School of Medicine, Chicago, IL.
authors.forename: Lynn P
authors.initials: LP
authors.lastname: Lowe
authors.affiliation: Obstetric Medicine, Melbourne School of Population and Global Health, University of Melbourne, Carlton, Victoria, Australia.
authors.forename: Jeremy J N
authors.initials: JJ
authors.lastname: Oats
authors.affiliation: Department of Pediatrics, Karolinska Institute, Stockholm, Sweden.
authors.forename: Bengt
authors.initials: B
authors.lastname: Persson
authors.affiliation: Department of Obstetrics and Gynecology, Kaiser Foundation Hospital, Bellflower, CA.
authors.forename: David A
authors.initials: DA
authors.lastname: Sacks
authors.affiliation: Northwestern University Feinberg School of Medicine, Chicago, IL.
authors.forename: Boyd E
authors.initials: BE
authors.lastname: Metzger
authors.affiliation: Department of Reproductive Biology, Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH.
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Catalano
mesh_terms: D000328:Adult; D016640:Diabetes, Gestational / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006943:Hyperglycemia / Q000175:diagnosis / Q000453:epidemiology*; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis / Q000453:epidemiology; D009017:Morbidity; D011225:Pre-Eclampsia / Q000175:diagnosis / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000453:epidemiology; D011256:Pregnancy Outcome / Q000453:epidemiology*; D011379:Prognosis; D017584:Reproductive History; D012189:Retrospective Studies