title: Evaluation of Glutathione Peroxidase 4 role in Preeclampsia.
abstract: Preeclampsia (PE) is a pregnancy-specific syndrome that may be lifethreatening to pregnancies and fetus. Glutathione Peroxidase 4 (GPx4) is a powerful antioxidant enzyme that can provide protection from oxidative stress damage which plays a pivotal role in the pathology of PE. Therefore, this study aims to investigate the association between Gpx4 polymorphisms and the susceptibility to PE in Chinese Han women. TaqMan allelic discrimination real-time PCR was used to perform the genotyping of rs713041 and rs4807542 in 1008 PE patients and 1386 normotensive pregnancies. Obviously statistical difference of genotypic and allelic frequencies were found of rs713041 in GPx4 between PE patients and controls and the C allele has the higher risk for pathogenesis of PE (χ(2) = 12.292, P = 0.002 by genotype; χ(2) = 11.035, P = 0.001, OR = 1.216, 95% CI 1.084-1.365 by allele). Additionally, when subdividing these samples into CC + CT and TT groups, we found a significant difference between the two groups (χ(2) = 11.241, P = 0.001, OR = 1.417, 95% CI 1.155-1.738). Furthermore, the genotype of rs713041 was found to be associated with the mild, severe and early-onset PE. Our results suggest that rs713041 in GPx4 may play a key role in the pathogenesis of PE.
authors.affiliation: Clinical Laboratory, Binzhou Medical University Hospital, Binzhou, China.
authors.forename: Xinguo
authors.initials: X
authors.lastname: Peng
authors.affiliation: Clinical Laboratory, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Clinical Laboratory, Binzhou Medical University Hospital, Binzhou, China.
authors.forename: Jinling
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Intensive Care Unit, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Mengchun
authors.initials: M
authors.lastname: Liu
authors.affiliation: Prenatal Diagnosis Center, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Jingli
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Histology and Embryology, Qingdao University Medical College, Qingdao, China.
authors.forename: Xueying
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Blood Transfusion, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of cardiovascular, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Xuewen
authors.initials: X
authors.lastname: Jia
authors.affiliation: Department of Blood Transfusion, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Zhongcui
authors.initials: Z
authors.lastname: Jing
authors.affiliation: Departmet of Haematology, Qingdao University Medical College, Qingdao, China.
authors.forename: Zuzhou
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Clinical Laboratory, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Kaiqiu
authors.initials: K
authors.lastname: Chu
authors.affiliation: Prenatal Diagnosis Center, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Shiguo
authors.initials: S
authors.lastname: Liu
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D005979:Glutathione Peroxidase / Q000235:genetics*; D006801:Humans; D000080662:Phospholipid Hydroperoxide Glutathione Peroxidase; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000208:ethnology / Q000235:genetics*; D011247:Pregnancy
chemical_list: D000080662:Phospholipid Hydroperoxide Glutathione Peroxidase; D005979:Glutathione Peroxidase