title: A method for safely resecting anterior butterfly gliomas: the surgical anatomy of the default mode network and the relevance of its preservation.
abstract: OBJECTIVE Gliomas invading the anterior corpus callosum are commonly deemed unresectable due to an unacceptable risk/benefit ratio, including the risk of abulia. In this study, the authors investigated the anatomy of the cingulum and its connectivity within the default mode network (DMN). A technique is described involving awake subcortical mapping with higher attention tasks to preserve the cingulum and reduce the incidence of postoperative abulia for patients with so-called butterfly gliomas. METHODS The authors reviewed clinical data on all patients undergoing glioma surgery performed by the senior author during a 4-year period at the University of Oklahoma Health Sciences Center. Forty patients were identified who underwent surgery for butterfly gliomas. Each patient was designated as having undergone surgery either with or without the use of awake subcortical mapping and preservation of the cingulum. Data recorded on these patients included the incidence of abulia/akinetic mutism. In the context of the study findings, the authors conducted a detailed anatomical study of the cingulum and its role within the DMN using postmortem fiber tract dissections of 10 cerebral hemispheres and in vivo diffusion tractography of 10 healthy subjects. RESULTS Forty patients with butterfly gliomas were treated, 25 (62%) with standard surgical methods and 15 (38%) with awake subcortical mapping and preservation of the cingulum. One patient (1/15, 7%) experienced postoperative abulia following surgery with the cingulum-sparing technique. Greater than 90% resection was achieved in 13/15 (87%) of these patients. CONCLUSIONS This study presents evidence that anterior butterfly gliomas can be safely removed using a novel, attention-task based, awake brain surgery technique that focuses on preserving the anatomical connectivity of the cingulum and relevant aspects of the cingulate gyrus.
authors.affiliation: Departments of 1 Neurosurgery.
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Burks
authors.affiliation: Departments of 1 Neurosurgery.
authors.forename: Phillip A
authors.initials: PA
authors.lastname: Bonney
authors.affiliation: Departments of 1 Neurosurgery.
authors.forename: Andrew K
authors.initials: AK
authors.lastname: Conner
authors.affiliation: Departments of 1 Neurosurgery.
authors.forename: Chad A
authors.initials: CA
authors.lastname: Glenn
authors.affiliation: Departments of 1 Neurosurgery.
authors.forename: Robert G
authors.initials: RG
authors.lastname: Briggs
authors.affiliation: Neurology.
authors.forename: James D
authors.initials: JD
authors.lastname: Battiste
authors.affiliation: Departments of 1 Neurosurgery.
authors.forename: Tressie
authors.initials: T
authors.lastname: McCoy
authors.affiliation: Cell Biology, and.
authors.forename: Daniel L
authors.initials: DL
authors.lastname: O'Donoghue
authors.affiliation: Radiological Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
authors.forename: Dee H
authors.initials: DH
authors.lastname: Wu
authors.affiliation: Departments of 1 Neurosurgery.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Sughrue
mesh_terms: D000328:Adult; D000368:Aged; D001931:Brain Mapping; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D056324:Diffusion Tensor Imaging; D005260:Female; D005910:Glioma / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods; D019635:Neurosurgical Procedures / Q000379:methods*
keywords: ACA = anterior cerebral artery; BOLD = blood oxygen level–dependent; CST = cingulum-sparing technique; DMN = default mode network; DTI; DTI = diffusion tensor imaging; EOR = extent of resection; GQI = generalized q-sampling imaging; GTR = gross-total resection; HGG = high-grade glioma; LGG = low-grade glioma; NTR = near-total resection; ROI = region of interest; SMA = supplementary motor area; STR = subtotal resection; anatomy; butterfly glioma; cingulate gyrus; cingulum; connectivity; corpus callosum; default mode network; fMRI = functional MRI; glioblastoma; oncology; tractography