title: [Serological tests for celiac disease in Moroccan patients with type 1 diabetes].
abstract: Celiac disease (CD) is an autoimmune disease frequently associated with type 1 diabetes (T1D). The prevalence of CD in patients with T1D varies from 3 to 6%. The clinical manifestation of CD in patients with T1D is classified as asymptomatic in about half of cases. Our study aims to determine the frequency of anti-tissue transglutaminase autoantibodies (IgA-tTG) and anti-gliadin antibodies (AGA) in patients with type 1 diabetes in order to early recommend jejunal biopsy and establish a gluten-free diet before the onset of clinical signs and complications of celiac disease. Subjects included in this study were patients with T1D and untreated CD who showed no signs of this disease. The detection of IgG tTG, IgG IgA and IgG AAG was performed using Luminex technology. We enrolled 31 patients. The study involved 16 men and 15 women. IgA AAG were positive in 4(13%) patients and IgG were positive in 7(22,5%) patients. IgA tTG were positive in 3(10%) patients and IgG was positive in one (3%) patient. In our study the association of diabetes type 1 with biomarkers of CD is not uncommon hence the importance of systematic screening for type 1 diabetes. The diagnosis of this atypical and silent CD form is important given the risk of serious complications such as malabsorption and gastrointestinal cancers.
authors.affiliation: Service de Transfusion Sanguine et d'Hémovigilance, Hôpital d'Enfants, CHU Rabat, UPR d'Immunologie, Faculté de Médecine et de Pharmacie de Rabat, Université Mohammed V Souissi, Maroc.
authors.forename: Asmaa Drissi
authors.initials: AD
authors.lastname: Bourhanbour
authors.affiliation: Service de Transfusion Sanguine et d'Hémovigilance, Hôpital d'Enfants, CHU Rabat, UPR d'Immunologie, Faculté de Médecine et de Pharmacie de Rabat, Université Mohammed V Souissi, Maroc.
authors.forename: Sanae
authors.initials: S
authors.lastname: Ouadghiri
authors.affiliation: Service de Transfusion Sanguine et d'Hémovigilance, Hôpital d'Enfants, CHU Rabat, UPR d'Immunologie, Faculté de Médecine et de Pharmacie de Rabat, Université Mohammed V Souissi, Maroc.
authors.forename: Nadia
authors.initials: N
authors.lastname: Benseffaj
authors.affiliation: Service de Transfusion Sanguine et d'Hémovigilance, Hôpital d'Enfants, CHU Rabat, UPR d'Immunologie, Faculté de Médecine et de Pharmacie de Rabat, Université Mohammed V Souissi, Maroc.
authors.forename: Malika
authors.initials: M
authors.lastname: Essakalli
mesh_terms: D001323:Autoantibodies / Q000276:immunology*; D001706:Biopsy; D002446:Celiac Disease / Q000175:diagnosis* / Q000178:diet therapy / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D055050:Diet, Gluten-Free; D005260:Female; D019204:GTP-Binding Proteins / Q000276:immunology; D005903:Gliadin / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D008297:Male; D009018:Morocco; D015995:Prevalence; D011446:Prospective Studies; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D012698:Serologic Tests; D011503:Transglutaminases / Q000276:immunology
chemical_list: D001323:Autoantibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D005903:Gliadin; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins
keywords: Celiac disease; serological test; type 1 diabetes