title: Collective Review of the Status of Rapid Sequence Intubation Drugs of Choice in Trauma in Low- and Middle-Income Settings (Prehospital, Emergency Department and Operating Room Setting).
abstract: Establishing a definitive airway in order to ensure adequate ventilation and oxygenation is an important aspect of resuscitation of the polytrauma patient .
  
  
  
  To review the relevant literature that compares the different drugs used for rapid sequence intubation (RSI) of trauma patients, specifically reviewing: premedication, induction agents and neuromuscular blocking agents across the prehospital, emergency department and operating room setting, and to present the best practices based on the reviewed evidence.
  
  
  
  A literature review of rapid sequence intubation in the trauma population was carried out, specifically comparison of the drugs used (induction agent, neuromuscular blocking drugs and adjuncts).
  
  
  
  Studies involving the comparison of drugs used in RSI in, specifically, the trauma patient are sparse. The majority of studies have compared induction agents, etomidate, ketamine and propofol, as well as the neuromuscular blocking agents, succinylcholine and rocuronium.
  
  
  
  There currently exists great variation in the practice of RSI; however, in trauma the RSI armamentarium is limited to agents that maintain hemodynamic stability, provide adequate intubating conditions in the shortest time period and do not have detrimental effects on cerebral perfusion pressure. Further, multicenter randomized controlled studies to confirm the benefits of the currently used agents in trauma are required.
authors.affiliation: Department of Anaesthetics, Inkosi Albert Luthuli Central Hospital, Mayville, Durban, KwaZulu-Natal, South Africa. leresse@gmail.com.|Division of Anaesthesiology and Critical Care, University of KwaZulu-Natal, Durban, South Africa. leresse@gmail.com.
authors.forename: Leressè
authors.initials: L
authors.lastname: Pillay
authors.affiliation: Trauma Unit, Inkosi Albert Luthuli Central Hospital, 800 Vusi Mzimela Rd, Mayville, Durban, 4058, KwaZulu-Natal, South Africa.|Trauma Training Unit, Department of Surgical Sciences, University of KwaZulu-Natal, Durban, South Africa.
authors.forename: Timothy
authors.initials: T
authors.lastname: Hardcastle
mesh_terms: D000328:Adult; D000732:Androstanols / Q000008:administration & dosage; D000778:Anesthetics, Dissociative / Q000008:administration & dosage; D018686:Anesthetics, Intravenous / Q000008:administration & dosage; D003906:Developing Countries; D004636:Emergency Service, Hospital; D005045:Etomidate / Q000008:administration & dosage; D006801:Humans; D007442:Intubation, Intratracheal / Q000379:methods*; D007649:Ketamine / Q000008:administration & dosage; D009104:Multiple Trauma / Q000628:therapy*; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage; D009873:Operating Rooms; D015742:Propofol / Q000008:administration & dosage; D000077123:Rocuronium; D013390:Succinylcholine / Q000008:administration & dosage
chemical_list: D000732:Androstanols; D000778:Anesthetics, Dissociative; D018686:Anesthetics, Intravenous; D003473:Neuromuscular Nondepolarizing Agents; D007649:Ketamine; D013390:Succinylcholine; D000077123:Rocuronium; D015742:Propofol; D005045:Etomidate