title: Estimating central blood pressure in the extreme vascular phenotype of advanced kidney disease.
abstract: Carlsen et al. demonstrated that the estimation of central blood pressure from peripheral tonometry does not work properly in patients with chronic kidney disease. We explore here the implications of this finding, first by considering the technical conditions for validating central BP monitors, then by discussing the possible causes for discrepancies between chronic kidney disease patients and usual study populations. Lastly, we review the merits and limits of the work by Carlsen et al.
authors.affiliation: Department of Pharmacology, European Georges Pompidou Hospital, Assistance Publique Hôpitaux de Paris, Institut National de la Santé et de la recherche médicale, unité mixte de recherche 970, Paris, France; Department of Pharmacology, University Paris Descartes, Paris, France. Electronic address: pierre.boutouyrie@egp.aphp.fr.
authors.forename: Pierre
authors.initials: P
authors.lastname: Boutouyrie
authors.affiliation: Department of Nephrology, Centre Hospitalier Manhès, Fleury-Mérogis, France.
authors.forename: Gérard M
authors.initials: GM
authors.lastname: London
authors.affiliation: Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
authors.forename: James E
authors.initials: JE
authors.lastname: Sharman
mesh_terms: D001794:Blood Pressure; D006801:Humans; D008365:Manometry; D010641:Phenotype; D017534:Radial Artery; D051436:Renal Insufficiency, Chronic; D059289:Vascular Stiffness