title: The role of ubiquitin-proteasome pathway in spermatogenesis.
abstract: Ubiquitin-proteasome pathway (UPP) is the main pathway of protein degradation in eukaryotic cells. The UPP plays very important roles in cell cycle progression, apoptosis, stress response and growth and development through regulating protein interaction, protein activity, protein localization and signal transduction. Previous studies have shown that the UPP is essential for regulating acrosome and tail biogenesis during spermatogenesis in human and animals. The dysregulation of UPP during spermatogenesis results in sperm deformity and reduced sperm motility and leads to reproductive system diseases such as oligospermatism, infertility and testicular tumors. In this review, we summarized the signal transduction and regulation mechanism of UPP in spermatogenesis, which may provide references for future studies.
authors.affiliation: 1. College of Animal Science & Technology, Hunan Agricultural University, Changsha 410128, China; 2. Hunan Provincial Key Laboratory for Genetic Improvement of Domestic Animal, Changsha 410128, China.
authors.forename: Lian-hua
authors.initials: LH
authors.lastname: Dong
authors.affiliation: 1. College of Animal Science & Technology, Hunan Agricultural University, Changsha 410128, China; 2. Hunan Provincial Key Laboratory for Genetic Improvement of Domestic Animal, Changsha 410128, China.
authors.forename: Mao-liang
authors.initials: ML
authors.lastname: Ran
authors.affiliation: 1. College of Animal Science & Technology, Hunan Agricultural University, Changsha 410128, China; 2. Hunan Provincial Key Laboratory for Genetic Improvement of Domestic Animal, Changsha 410128, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Li
authors.affiliation: 1. College of Animal Science & Technology, Hunan Agricultural University, Changsha 410128, China; 2. Hunan Provincial Key Laboratory for Genetic Improvement of Domestic Animal, Changsha 410128, China.
authors.forename: Fu-zhi
authors.initials: FZ
authors.lastname: Peng
authors.affiliation: 1. College of Animal Science & Technology, Hunan Agricultural University, Changsha 410128, China; 2. Hunan Provincial Key Laboratory for Genetic Improvement of Domestic Animal, Changsha 410128, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Chen
mesh_terms: D000818:Animals; D006801:Humans; D008297:Male; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D013091:Spermatogenesis / Q000502:physiology*; D013094:Spermatozoa / Q000378:metabolism / Q000502:physiology; D025801:Ubiquitin / Q000378:metabolism*
chemical_list: D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex