title: Prenylated isoflavones from Cudrania tricuspidata inhibit NO production in RAW 264.7 macrophages and suppress HL-60 cells proliferation.
abstract: Inhibitory effects of NO production in RAW 264.7 macrophages guided the isolation of nine prenylated isoflavones, including a new cudraisoflavone L (1) and eight known metabolites furowanin B (2), erysubin A (3), wighteone (4), lupalbigenin (5), laburnetin (6), isolupalbigenin (7), 6,8-diprenylorobol (8), millewanin H (9) from the leaves of Cudrania tricuspidata. At the concentration of 10 μM, compounds 1, 2, and 4 significantly inhibited NO production with the inhibitory values of 72.5 ± 2.4, 66.9 ± 1.8, and 55.4 ± 2.7%, respectively. In addition, all of isolated compounds 1-9 showed promising cytotoxic effects toward HL-60 cells (IC504.3 ± 0.7 to 18.0 ± 1.7 μM).
authors.affiliation: a Institute of Marine Biochemistry , Vietnam Academy of Science and Technology , Hanoi , Vietnam.
authors.forename: Hoang Le
authors.initials: HL
authors.lastname: Tuan Anh
authors.affiliation: b Department of Biology , Thaibinh Medical University , Thaibinh , Vietnam.
authors.forename: Do Thanh
authors.initials: DT
authors.lastname: Tuan
authors.affiliation: a Institute of Marine Biochemistry , Vietnam Academy of Science and Technology , Hanoi , Vietnam.
authors.forename: Do Thi
authors.initials: DT
authors.lastname: Trang
authors.affiliation: a Institute of Marine Biochemistry , Vietnam Academy of Science and Technology , Hanoi , Vietnam.
authors.forename: Bui Huu
authors.initials: BH
authors.lastname: Tai
authors.affiliation: a Institute of Marine Biochemistry , Vietnam Academy of Science and Technology , Hanoi , Vietnam.
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Nhiem
authors.affiliation: a Institute of Marine Biochemistry , Vietnam Academy of Science and Technology , Hanoi , Vietnam.
authors.forename: Pham Hai
authors.initials: PH
authors.lastname: Yen
authors.affiliation: a Institute of Marine Biochemistry , Vietnam Academy of Science and Technology , Hanoi , Vietnam.
authors.forename: Phan Van
authors.initials: PV
authors.lastname: Kiem
authors.affiliation: a Institute of Marine Biochemistry , Vietnam Academy of Science and Technology , Hanoi , Vietnam.
authors.forename: Chau Van
authors.initials: CV
authors.lastname: Minh
authors.affiliation: c Department of Anatomy , Vietnam University of Traditional Medicine , Hanoi , Vietnam.
authors.forename: Tran Minh
authors.initials: TM
authors.lastname: Duc
authors.affiliation: d School of Medicine and Institute of Medical Science, Jeju University , Jeju 690-756 , Korea.
authors.forename: Hee Kyoung
authors.initials: HK
authors.lastname: Kang
authors.affiliation: e College of Pharmacy, Wonkwang University , Iksan 570-749 , Korea.
authors.forename: Youn Chul
authors.initials: YC
authors.lastname: Kim
authors.affiliation: f College of Pharmacy, Chungnam National University , Daejeon 34134 , Korea.
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019610:Cytoprotection / Q000187:drug effects*; D018922:HL-60 Cells; D006801:Humans; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D029586:Moraceae / Q000737:chemistry; D009569:Nitric Oxide / Q000096:biosynthesis*; D018517:Plant Roots / Q000737:chemistry; D054876:Prenylation
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007529:Isoflavones; C000617260:cudraisoflavone L; C508678:furowanin B; C508677:millewanin H; D009569:Nitric Oxide
keywords: Cudrania tricuspidata; NO inhibitor; Prenylated isoflavone; anti-leukemia; cudraisoflavone L