title: Investigation of First Identified mcr-1 Gene in an Isolate from a U.S. Patient - Pennsylvania, 2016.
abstract: In 2015, scientists reported the emergence of the plasmid-encoded mcr-1 gene conferring bacterial resistance to the antibiotic colistin (1), signaling potential emergence of a pandrug-resistant bacterium. In May 2016, mcr-1-positive Escherichia coli was first isolated from a specimen from a U.S. patient (2) when a Pennsylvania woman was evaluated for a urinary tract infection. The urine culture and subsequent testing identified the gene in an extended-spectrum beta-lactamase (ESBL)-producing E. coli with reduced susceptibility to colistin. The patient had no international travel for approximately 1 year, no livestock exposure, and a limited role in meal preparation with store-bought groceries; however, she had multiple and repeated admissions to four medical facilities during 2016.
authors.forename: Kelly E
authors.initials: KE
authors.lastname: Kline
authors.forename: Jordan
authors.initials: J
authors.lastname: Shover
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Kallen
authors.forename: David R
authors.initials: DR
authors.lastname: Lonsway
authors.forename: Sharon
authors.initials: S
authors.lastname: Watkins
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Miller
mesh_terms: D003091:Colistin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification*; D004927:Escherichia coli Infections / Q000382:microbiology*; D005260:Female; D006801:Humans; D010414:Pennsylvania; D014552:Urinary Tract Infections / Q000382:microbiology*
chemical_list: D003091:Colistin