title: Aptamers in hematological malignancies and their potential therapeutic implications.
abstract: Aptamers are short DNA/RNA oligonucleotides selected by the process called Systematic Evolution of Ligands by Exponential Enrichment (SELEX). Due to their functional similarity to monoclonal antibodies with some superior characters, such as high specificity and affinity, flexible modification and stability, and lack of toxicity and immunogenicity, they are promising alternative and complementary targeted therapy for hematologic malignancies. The trends in aptamer technology including production, selection, modifications are briefly discussed in this review. The key aspect is to illustrate aptamers against cancer cells in hematologic malignancies especially those that have entered clinical trials. We also discuss some challenges remain in the application of aptamers.
authors.affiliation: Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Wanyan
authors.initials: W
authors.lastname: Ouyang
authors.affiliation: Nanjing Medical University, Affiliated Wuxi Second Hospital, Department of Hematology, Wuxi 214002, China; Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Ziqiang
authors.initials: Z
authors.lastname: Yu
authors.affiliation: Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Shiyun
authors.initials: S
authors.lastname: Lu
authors.affiliation: Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, China. Electronic address: oywy1618@163.com.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Wang
mesh_terms: D052157:Aptamers, Nucleotide / Q000235:genetics / Q000627:therapeutic use*; D019337:Hematologic Neoplasms / Q000235:genetics / Q000628:therapy*; D006801:Humans; D058990:Molecular Targeted Therapy; D052156:SELEX Aptamer Technique
chemical_list: D052157:Aptamers, Nucleotide
keywords: Aptamer; Hematologic malignancies; Targeted therapy