title: Transthyretin and Normal Human Pregnancy: Mini Review.
abstract: Since transthyretin (TTR) was discovered, it has been regarded as a serum protein carrier of thyroid hormones and retinol. However, many other important functions of TTR have been found recently, and current evidence suggests that it plays a role in human receptivity and normal pregnancy. TTR is abundant in the uterine cavity, uterine secretion, placenta, and serum of pregnant females in the peri-implantation uterus and the first trimester of pregnancy. It may be involved in the delivery of maternal thyroid hormones to the fetus. In addition, it appears to play a key role in the preeclampsia mechanism and may be involved in spiral artery remodeling. This review will summarize what is currently known about TTR and normal pregnancy; it will focus on our findings regarding the role of TTR in the spiral artery remodeling process and the additional research required in the future.
authors.affiliation: Department of Obstetrics and Gynecology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
authors.forename: Qiushi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
authors.forename: Chongdong
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Obstetrics and Gynecology, Beijing Chaoyang Hospital, Capital Medical University.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D002352:Carrier Proteins / Q000378:metabolism; D005260:Female; D006801:Humans; D010920:Placenta / Q000378:metabolism; D011228:Prealbumin / Q000378:metabolism* / Q000502:physiology; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000378:metabolism*; D013963:Thyroid Hormones / Q000378:metabolism; D014327:Trophoblasts / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D011228:Prealbumin; D013963:Thyroid Hormones