title: Impact of Gestational Diabetes Mellitus and Maternal Obesity on Cord Blood Dynamic Thiol/Disulfide Homeostasis.
abstract: OBJECTIVE
  Our aim in this study was to investigate the effect of maternal obesity and gestational diabetes mellitus (GDM) on cord blood dynamic thiol/disulfide homeostasis.
  
  
  METHODS
  A prospective case-control study was carried out in 125 pregnant women (27 GDM, 30 obese, 68 controls). Cord blood samples were collected from all participants and native thiol-disulfide exchanges were examined with automated method enabling the measurement of both sides of thiol-disulfide balance.
  
  
  RESULTS
  Disulfide amounts, disulfide/native thiol and disulfide/total thiol ratios were increased (p < 0.001), while native thiol/total thiol was decreased in the cord blood of babies born to an obese or diabetic mother (p < 0.001). Moreover, increased disulfide amounts, disulfide/native thiol, disulfide/totalthiol ratios and decreased native/total thiol were found to be significantly associated with adverse outcomes in GDM.
  
  
  CONCLUSIONS
  The current study suggests that the offsprings born to obese or diabetic mothers are exposed to increased oxidative stress.
authors.affiliation: a Zekai Tahir Burak Women's Health Education and Research Hospital , Department of Perinatology , Ankara , Turkey.
authors.forename: Sibel
authors.initials: S
authors.lastname: Ozler
authors.affiliation: a Zekai Tahir Burak Women's Health Education and Research Hospital , Department of Perinatology , Ankara , Turkey.
authors.forename: Efser
authors.initials: E
authors.lastname: Oztas
authors.affiliation: b Department of Clinical Biochemistry, Faculty of Medicine , Yildirim Beyazit University , Ankara , Turkey.
authors.forename: Ozcan
authors.initials: O
authors.lastname: Erel
authors.affiliation: c Department of Obstetrics and Gynecology , Liv Hospital , Ankara , Turkey.
authors.forename: Basak Gumus
authors.initials: BG
authors.lastname: Guler
authors.affiliation: d Aralık State Hospital , Gaziantep , Turkey.
authors.forename: Merve
authors.initials: M
authors.lastname: Ergin
authors.affiliation: a Zekai Tahir Burak Women's Health Education and Research Hospital , Department of Perinatology , Ankara , Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Uygur
authors.affiliation: a Zekai Tahir Burak Women's Health Education and Research Hospital , Department of Perinatology , Ankara , Turkey.
authors.forename: Nuri
authors.initials: N
authors.lastname: Danisman
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000503:physiopathology*; D004220:Disulfides / Q000737:chemistry*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006706:Homeostasis; D006801:Humans; D016014:Linear Models; D009765:Obesity / Q000150:complications / Q000503:physiopathology*; D018384:Oxidative Stress; D011247:Pregnancy; D011248:Pregnancy Complications; D011446:Prospective Studies; D012372:ROC Curve; D012680:Sensitivity and Specificity; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D016896:Treatment Outcome
chemical_list: D004220:Disulfides; D013438:Sulfhydryl Compounds
keywords: Adverse perinatal outcomes; gestational diabetes mellitus; maternal obesity; thiol/disulfide homeostasis