title: Water-Promoted Regiospecific Azidolysis and Copper-Catalyzed Azide-Alkyne Cycloaddition: One-Pot Synthesis of 3-Hydroxy-1-alkyl-3-[(4-aryl/alkyl-1H-1,2,3-triazol-1-yl)methyl]indolin-2-ones.
abstract: An efficient, eco-friendly, base free, one-pot, sequential protocol was developed for epoxide azidolysis and copper-catalyzed azide-alkyne cycloaddition using water as the solvent for the synthesis of 3-hydroxy-1-alkyl-3-[(4-aryl/alkyl-1H-1,2,3-triazol-1-yl)methyl]indolin-2-ones. The optimized reaction conditions have been generalized in the case of aromatic as well as aliphatic alkyne partners to afford good yields and high regioselectivity.
authors.affiliation: Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research , Sector 67, SAS Nagar, Punjab 160062, India.|Department of Pharmaceutical Chemistry, Indo-Soviet Friendship College of Pharmacy (ISFCP) , Moga, Punjab 142001, India.
authors.forename: Kapil
authors.initials: K
authors.lastname: Kumar
authors.affiliation: Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research , Sector 67, SAS Nagar, Punjab 160062, India.
authors.forename: Debabrata
authors.initials: D
authors.lastname: Konar
authors.affiliation: Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research , Sector 67, SAS Nagar, Punjab 160062, India.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Goyal
authors.affiliation: Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research , Sector 67, SAS Nagar, Punjab 160062, India.
authors.forename: Mukesh
authors.initials: M
authors.lastname: Gangar
authors.affiliation: Department of Pharmaceutical Sciences, Mohanlal Sukhadia University , Udaipur, Rajasthan 313001, India.
authors.forename: Mangilal
authors.initials: M
authors.lastname: Chouhan
authors.affiliation: Department of Pharmaceutical Chemistry, Indo-Soviet Friendship College of Pharmacy (ISFCP) , Moga, Punjab 142001, India.
authors.forename: Ravindra K
authors.initials: RK
authors.lastname: Rawal
authors.affiliation: Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research , Sector 67, SAS Nagar, Punjab 160062, India.
authors.forename: Vipin A
authors.initials: VA
authors.lastname: Nair