title: Circulating Resistin Levels and Risk of Colorectal Cancer: A Meta-Analysis.
abstract: Objectives. Published data on resistin levels in patients with colorectal cancer (CRC) were conflicting and heterogeneous. We conducted a meta-analysis of observational studies to examine the association of circulating resistin levels with carcinogenesis of the CRC. Methods. Potentially eligible studies published up to November 2015 were searched through MEDLINE, EMBASE, Science Citation Index Expanded database, CNKI, and WanFang database. The pooled weighted mean differences (WMDs) with 95% confidence intervals (CIs) calculated by fixed- or random-effect model were used to estimate the effects. Results. A total of 11 studies involving 965 patients were admitted in our meta-analysis. The pooled effects indicated that resistin levels were higher in CRC patients compared to healthy controls (WMD: 1.47 ng/mL; 95% CI: 0.78 to 2.16), with significant heterogeneity across the studies (I (2) = 72%, p < 0.0001). Subgroup analyses and sensitivity analyses revealed that study quality, design, sample type, and resistin assays may account for this heterogeneity. No publication bias was observed. Conclusions. Our meta-analysis suggests that increased circulating resistin levels are associated with greater risk of colorectal cancer. Given the limited number of available studies and significant heterogeneity, larger well-designed randomized studies are warranted.
authors.affiliation: Department of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
authors.forename: Gui
authors.initials: G
authors.lastname: Yang
authors.affiliation: Department of Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Fan
authors.affiliation: Department of Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
authors.forename: Baohong
authors.initials: B
authors.lastname: Luo
authors.affiliation: Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
authors.forename: Zhigao
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Department of Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.affiliation: Department of Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
authors.forename: Shihui
authors.initials: S
authors.lastname: Tang
authors.affiliation: Department of Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
authors.forename: Peipei
authors.initials: P
authors.lastname: Xu
authors.affiliation: Department of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan 430071, China; Department of Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
authors.forename: Mingxia
authors.identifier: 0000-0002-0529-0030
authors.initials: M
authors.lastname: Yu
mesh_terms: D063646:Carcinogenesis / Q000473:pathology; D016022:Case-Control Studies; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000097:blood* / Q000209:etiology* / Q000473:pathology; D006801:Humans; D064887:Observational Studies as Topic; D052243:Resistin / Q000097:blood*; D012306:Risk; D012680:Sensitivity and Specificity
chemical_list: D052243:Resistin