title: Overstimulation of the inhibitory nervous system plays a role in the pathogenesis of neuromuscular and neurological diseases: a novel hypothesis.
abstract: Based upon a thorough review of published clinical observations regarding the inhibitory system, I hypothesize that this system may play a key role in the pathogenesis of a variety of neuromuscular and neurological diseases. Specifically, excitatory overstimulation, which is commonly reported in neuromuscular and neurological diseases, may be a homeostatic response to inhibitory overstimulation. Involvement of the inhibitory system in disease pathogenesis is highly relevant, given that most approaches currently being developed for treating neuromuscular and neurological diseases focus on reducing excitatory activity rather than reducing inhibitory activity.
authors.affiliation: Leiden Academic Center for Drug Research (LACDR), Leiden University, Leiden, 2333 CC, Netherlands; Ry Pharma, Hofstraat 1, Willemstad, 4797 AC, Netherlands.
authors.forename: Bert
authors.initials: B
authors.lastname: Tuk
keywords: ALS; Alzheimer’s disease; FTD; Huntington’s disease; Neuromuscular disease; Parkinson’s disease; Primary Lateral Sclerosis; neurodegeneration