title: A link between TP53 polymorphisms and metabolism.
abstract: Besides being a critical tumor suppressor, the TP53 gene also plays a role in metabolism and recent studies in humans have implicated the codon 72 polymorphism of TP53 in this role. Using a humanized knock-in mouse model for these TP53 variants, we show that this polymorphism has a significant impact on the metabolic response to a high-fat diet.
authors.affiliation: Molecular and Cellular Oncogenesis Program, The Wistar Institute , Philadelphia, PA, USA.
authors.forename: Che-Pei
authors.initials: CP
authors.lastname: Kung
authors.affiliation: Molecular and Cellular Oncogenesis Program, The Wistar Institute , Philadelphia, PA, USA.
authors.forename: Subhasree
authors.initials: S
authors.lastname: Basu
authors.affiliation: Molecular and Cellular Oncogenesis Program, The Wistar Institute , Philadelphia, PA, USA.
authors.forename: Maureen E
authors.initials: ME
authors.lastname: Murphy
keywords: Diabetes; Npc1l1; Tnf; inflammation; lipid metabolism; obesity; p53 polymorphism