title: Phyto-glycosides as Therapeutic Target in the Treatment of Diabetes.
abstract: Diabetes is a chronic metabolic disorder characterized by increased level of glucose in the blood due to defects in insulin action, insulin secretion or both. The effective management of diabetes is extremely important, otherwise, chronic uncontrolled diabetes could lead to diabetes late complications namely neuropathy, retinopathy, cardiomyopathy and nephropathy. The survey has shown that diabetes mellitus is one of the five leading causes of death all over the world. The therapeutic agents in clinical practice are facing the challenge of several unwanted effects, ineffectiveness in a large population and patient compliance therefore, new effective therapies are most warrant. In this connection, the natural product could be the best option as already accepted therapeutic modality since time immemorial. This review encounters various plant derived glycosides with antidiabetic effects; mediated through different mechanism(s). It is concluded that focusing glycosides as antidiabetic therapy could lead to the discovery of some new effective therapeutic agents.
authors.affiliation: Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, KPK. Pakistan.
authors.forename: Sumaira
authors.initials: S
authors.lastname: Khattak
authors.affiliation: Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, KPK. Pakistan.
authors.forename: Haroon
authors.initials: H
authors.lastname: Khan
mesh_terms: D000818:Animals; D003920:Diabetes Mellitus / Q000188:drug therapy*; D006027:Glycosides / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000627:therapeutic use*; D015394:Molecular Structure
chemical_list: D006027:Glycosides; D007004:Hypoglycemic Agents
keywords: Antidiabetic effects; antidiabetic therapy; diabetes mellitus; mechnism(s); plantglycosides; therapeutic agents