title: Association between insulin-like growth factor-binding protein-3 polymorphism-202 A/C and the risk of prostate cancer: a meta-analysis.
abstract: BACKGROUND
  Some previous studies have investigated the relationship between insulin-like growth factor-binding protein-3 polymorphism and prostate cancer (PCa) susceptibility; however, the findings from those studies remain inconsistent. Hence, the aim of this meta-analysis was to provide a more reliable conclusion about such associations.
  
  
  METHODS
  A meta-analysis based on twelve studies was conducted, and 8,341 PCa cases and 7,734 controls were included in this analysis. All relevant studies published till February 1, 2016, were identified by searching the databases such as PubMed, EMBASE, and Web of Science. Data were pooled by odds ratios (ORs) with 95% confidence intervals (CIs) in order to assess the strength of such associations. Publication bias was evaluated using Begg's funnel plots and Egger's regression test.
  
  
  RESULTS
  Several articles provided data only for particular genotypes; therefore, only dominant model analyses were carried out for all of these studies. Initially, the results from this analysis indicated that rs2854744 was not associated with PCa susceptibility (OR=1.12, 95% CI=0.996-1.2). However, after excluding one study due to its heterogeneity and publication bias, a significant relationship was detected between rs2854744 and PCa risk (OR=1.10, 95% CI=1.03-1.17). When stratified by genotyping method, significant results were detected only in the Sequenom method group (OR=1.13, 95% CI=1.04-1.22). Moreover, the results from a subgroup analysis that was conducted by using source of controls were significant only in the population-based control group.
  
  
  CONCLUSIONS
  This meta-analysis suggested that the insulin-like growth factor-binding protein-3 polymorphism-202 A/C was associated with PCa susceptibility.
authors.affiliation: Department of Urologic Surgery, The Affiliated Cancer Hospital of Jiangsu Province of Nanjing Medical University; Department of Urology, The First Affiliated Hospital of Nanjing Medical University.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Qin
authors.affiliation: Department of Urologic Surgery, The Affiliated Cancer Hospital of Jiangsu Province of Nanjing Medical University.
authors.forename: Xiao
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University.
authors.forename: Jingyuan
authors.initials: J
authors.lastname: Tang
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University.
authors.forename: Xuping
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University.
authors.forename: Yajie
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University.
authors.forename: Chengming
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Thoracic Surgery, The Affiliated Cancer Hospital of Jiangsu Province of Nanjing Medical University; Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, People's Republic of China.
authors.forename: Weizhang
authors.initials: W
authors.lastname: Xu
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University.
authors.forename: Yibo
authors.initials: Y
authors.lastname: Hua
authors.affiliation: Department of Urologic Surgery, The Affiliated Cancer Hospital of Jiangsu Province of Nanjing Medical University.
authors.forename: Bin
authors.initials: B
authors.lastname: Yu
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
keywords: IGFBP3; gene polymorphism; meta-analysis; prostate cancer