title: The C57BL/6J mice offspring originated from a parental generation exposed to tannery effluents shows object recognition deficits.
abstract: The main aim of the present paper is to assess whether the parental generation exposure to such discharges could cause object recognition deficits in their offspring. Male and female C57Bl/6J mice were put to mate after they were exposed to 7.5% and 15% tannery effluents or water (control group), for 60 days. The male mice were withdrawn from the boxes after 15 days and the female mice remained exposed to the treatment during the gestation and lactation periods. The offspring were subjected to the object recognition test after weaning in order to assess possible cognition losses. The results of the analysis of the novel object recognition index found in the testing session (performed 1 h after the training session) applied to offspring from different experimental groups appeared to be statistically different. The novel object recognition index of the offspring from female mice exposed to tannery effluents (7.5% and 15% groups) was lower than that of the control group, and it demonstrated object recognition deficit in the studied offspring. The present study is the first to report evidences that parental exposure to effluent of tannery (father and mother) can cause object recognition deficit in the offspring, which is related to problems in the central nervous system.
authors.affiliation: Programa de Pós-Graduação em Conservação de Recursos Naturais do Cerrado, Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil; Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil.
authors.forename: Abraão Tiago Batista
authors.initials: AT
authors.lastname: Guimarães
authors.affiliation: Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil.
authors.forename: Raíssa de Oliveira
authors.initials: RO
authors.lastname: Ferreira
authors.affiliation: Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil.
authors.forename: Letícia Martins
authors.initials: LM
authors.lastname: Rabelo
authors.affiliation: Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil.
authors.forename: Bianca Costa
authors.initials: BC
authors.lastname: E Silva
authors.affiliation: Programa de Pós-Graduação em Conservação de Recursos Naturais do Cerrado, Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil; Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil.
authors.forename: Joyce Moreira
authors.initials: JM
authors.lastname: de Souza
authors.affiliation: Programa de Pós-Graduação em Conservação de Recursos Naturais do Cerrado, Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil; Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil.
authors.forename: Wellington Alves Mizael
authors.initials: WA
authors.lastname: da Silva
authors.affiliation: Departamento de Ciências Biológicas, Programa de Pós-Graduação em Conservação de Recursos Naturais do Cerrado, Instituto Federal Goiano - Campus Urutaí, GO, Brazil.
authors.forename: Ivandilson Pessoa Pinto
authors.initials: IP
authors.lastname: de Menezes
authors.affiliation: Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil; Departamento de Ciências Biológicas, Programa de Pós-Graduação em Conservação de Recursos Naturais do Cerrado, Instituto Federal Goiano - Campus Urutaí, GO, Brazil.
authors.forename: Aline Sueli de Lima
authors.initials: AS
authors.lastname: Rodrigues
authors.affiliation: Programa de Pós-Graduação em Química, Universidade Federal de Goiás - Campus Samambaia, Goiânia, GO, Brazil.
authors.forename: Boniek Gontijo
authors.initials: BG
authors.lastname: Vaz
authors.affiliation: Programa de Pós-Graduação em Química, Universidade Federal de Goiás - Campus Samambaia, Goiânia, GO, Brazil.
authors.forename: Denys Ribeiro
authors.initials: DR
authors.lastname: de Oliveira Costa
authors.affiliation: Programa de Pós-Graduação em Química, Universidade Federal de Goiás - Campus Samambaia, Goiânia, GO, Brazil.
authors.forename: Igor
authors.initials: I
authors.lastname: Pereira
authors.affiliation: Departamento de Ciências Agrárias, Laboratório de Estatística Experimental, Instituto Federal Goiano - Campus Urutaí, GO, Brazil.
authors.forename: Anderson Rodrigo
authors.initials: AR
authors.lastname: da Silva
authors.affiliation: Programa de Pós-Graduação em Conservação de Recursos Naturais do Cerrado, Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil; Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil; Departamento de Ciências Biológicas, Programa de Pós-Graduação em Conservação de Recursos Naturais do Cerrado, Instituto Federal Goiano - Campus Urutaí, GO, Brazil; Programa de Pós-Graduação em Biodiversidade Animal, Universidade Federal de Goiás - Campus Samambaia, Goiânia, GO, Brazil. Electronic address: guilhermeifgoiano@gmail.com.
authors.forename: Guilherme
authors.initials: G
authors.lastname: Malafaia
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018812:Paternal Exposure / Q000009:adverse effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D021641:Recognition, Psychology / Q000187:drug effects*; D014796:Visual Perception / Q000187:drug effects*; D062065:Wastewater / Q000633:toxicity*
chemical_list: D062065:Wastewater
keywords: Agro-industrial effluents; Experimental models; Toxicity; Xenobiotics