title: A new patchoulane-type sesquiterpenoid glycoside from the roots of Croton crassifolius.
abstract: A new patchoulane-type sesquiterpenoid glycoside (1), together with five known sesquiterpenoids (2-6), was isolated from the roots of Croton crassifolius. Their structures were elucidated on the basis of spectroscopic methods. This is the first report about the sesquiterpenoid glycoside from C. crassifolius. All the isolated compounds 1-6 were evaluated for their cytotoxic activities against human tumour cell lines HL-60 and A549, but none showed significant activity.
authors.affiliation: a State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai , P.R. China.|b College of pharmacy , University of Chinese Academy of Sciences , Beijing , P.R. China.
authors.forename: Qing-Qing
authors.initials: QQ
authors.lastname: Yuan
authors.affiliation: a State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai , P.R. China.|b College of pharmacy , University of Chinese Academy of Sciences , Beijing , P.R. China.
authors.forename: Wei-Bin
authors.initials: WB
authors.lastname: Song
authors.affiliation: a State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai , P.R. China.|b College of pharmacy , University of Chinese Academy of Sciences , Beijing , P.R. China.
authors.forename: Wen-Qiong
authors.initials: WQ
authors.lastname: Wang
authors.affiliation: a State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai , P.R. China.|b College of pharmacy , University of Chinese Academy of Sciences , Beijing , P.R. China.
authors.forename: Li-Jiang
authors.initials: LJ
authors.lastname: Xuan
mesh_terms: D000072283:A549 Cells; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D029802:Croton / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013057:Spectrum Analysis
chemical_list: D006027:Glycosides; D012717:Sesquiterpenes
keywords: Croton crassifolius; cytotoxic activity; sesquiterpenoid glycoside