title: Primary Cilia and Coordination of Receptor Tyrosine Kinase (RTK) and Transforming Growth Factor β (TGF-β) Signaling.
abstract: Since the beginning of the millennium, research in primary cilia has revolutionized our way of understanding how cells integrate and organize diverse signaling pathways during vertebrate development and in tissue homeostasis. Primary cilia are unique sensory organelles that detect changes in their extracellular environment and integrate and transmit signaling information to the cell to regulate various cellular, developmental, and physiological processes. Many different signaling pathways have now been shown to rely on primary cilia to function properly, and mutations that lead to ciliary dysfunction are at the root of a pleiotropic group of diseases and syndromic disorders called ciliopathies. In this review, we present an overview of primary cilia-mediated regulation of receptor tyrosine kinase (RTK) and transforming growth factor β (TGF-β) signaling. Further, we discuss how defects in the coordination of these pathways may be linked to ciliopathies.
authors.affiliation: Department of Biology, University of Copenhagen, DK-2100 Copenhagen OE, Denmark.
authors.forename: Søren T
authors.identifier: http://orcid.org/0000-0001-5004-304X
authors.initials: ST
authors.lastname: Christensen
authors.affiliation: Department of Biology, University of Copenhagen, DK-2100 Copenhagen OE, Denmark.
authors.forename: Stine K
authors.initials: SK
authors.lastname: Morthorst
authors.affiliation: Department of Biology, University of Copenhagen, DK-2100 Copenhagen OE, Denmark.
authors.forename: Johanne B
authors.initials: JB
authors.lastname: Mogensen
authors.affiliation: Department of Biology, University of Copenhagen, DK-2100 Copenhagen OE, Denmark.
authors.forename: Lotte B
authors.initials: LB
authors.lastname: Pedersen
mesh_terms: D041721:3T3-L1 Cells; D000818:Animals; D002502:Centrioles / Q000378:metabolism; D002923:Cilia / Q000378:metabolism*; D004705:Endocytosis; D015894:Genome, Human; D006056:Golgi Apparatus / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D051379:Mice; D008856:Microscopy, Fluorescence; D009154:Mutation; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000378:metabolism; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000378:metabolism; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000378:metabolism*
chemical_list: D007328:Insulin; D016212:Transforming Growth Factor beta; D007334:Insulin-Like Growth Factor I; C000605860:PDGFRB protein, human; D020794:Receptor Protein-Tyrosine Kinases; D020796:Receptor, Platelet-Derived Growth Factor alpha; D020797:Receptor, Platelet-Derived Growth Factor beta