title: Serum interleukin-6: Association with circulating cytokine serum levels in patients with sinus arrhythmia and patients with coronary artery disease.
abstract: In this study, we were focused on the differences between certain circulating cytokine levels in patients with or without sinus arrhythmia, according to the median IL-6 level. All patients were stable with regards to symptoms and therapy for at least one month prior to the measurements conducted within this study.Exclusion criteria were: patients with sleep apnea, asthma, respiratory insufficiency of any genesis, active infection, allergy, inflammatory diseases, cancer, diabetes of any type and treatment with anti-inflammatory drugs. The study was approved by the Institutional Review Board. All recruited patients gave their verbal and written consent for participation in the study. The study group consisted of 74 patients divided into two groups: with (38) and without sinus arrhythmia but with diagnosed coronary artery disease (36). Sinus arrhythmia was confirmed by 24h Holter monitoring. From all test parameters only cytokines IL-2, IL-8, IL-10, IL-17 and IL-18, showed statistically significant increasing in patients with statistically higher IL-6 levels. It is possible that IL-6 may not be a marker for the selection of patients with sinus arrhythmia or coronary artery disease. The findings indicate that IL-6 represents a reliable indicator for increased expression of IL-2, IL-8, IL-10, IL-17 and IL-18 in patients with sinus arrhythmia or coronary artery disease. Further studies in a large number of patients would be necessary to confirm our observations.
authors.affiliation: Federal Scientific Clinical Center for Specialized Types of Medical Assistance and Medical Technologies for the Federal Medical and Biological Agency, Orekhoviy Boulevard 28, Moscow 115682, Russia; Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia.
authors.forename: A L
authors.initials: AL
authors.lastname: Shim
authors.affiliation: Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Aksyonov
authors.affiliation: Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia. Electronic address: vmitrohin@gmail.com.
authors.forename: V M
authors.initials: VM
authors.lastname: Mitrokhin
authors.affiliation: Federal Scientific Clinical Center for Specialized Types of Medical Assistance and Medical Technologies for the Federal Medical and Biological Agency, Orekhoviy Boulevard 28, Moscow 115682, Russia.
authors.forename: I B
authors.initials: IB
authors.lastname: Lovchikova
authors.affiliation: Federal Scientific Clinical Center for Specialized Types of Medical Assistance and Medical Technologies for the Federal Medical and Biological Agency, Orekhoviy Boulevard 28, Moscow 115682, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Konoplyannikov
authors.affiliation: Federal Scientific Clinical Center for Specialized Types of Medical Assistance and Medical Technologies for the Federal Medical and Biological Agency, Orekhoviy Boulevard 28, Moscow 115682, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Konev
authors.affiliation: Federal Scientific Clinical Center for Specialized Types of Medical Assistance and Medical Technologies for the Federal Medical and Biological Agency, Orekhoviy Boulevard 28, Moscow 115682, Russia.
authors.forename: A S
authors.initials: AS
authors.lastname: Zotov
authors.affiliation: Federal Scientific Clinical Center for Specialized Types of Medical Assistance and Medical Technologies for the Federal Medical and Biological Agency, Orekhoviy Boulevard 28, Moscow 115682, Russia; Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia.
authors.forename: R S
authors.initials: RS
authors.lastname: Ovchinnikov
authors.affiliation: Medical Faculty, University Clinic of Cardiology, "Ss. Cyril and Methodius" University, 1000 Skopje, Macedonia.
authors.forename: E
authors.initials: E
authors.lastname: Antova
authors.affiliation: Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia; Faculty of Natural Sciences and Mathematics, Institute of Biology, "Ss. Cyril and Methodius" University, P.O. Box 162, 1000 Skopje, Macedonia. Electronic address: m.mitko@gmail.com.
authors.forename: M I
authors.initials: MI
authors.lastname: Mladenov
authors.affiliation: Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia.
authors.forename: A
authors.initials: A
authors.lastname: Kamkin
mesh_terms: D000328:Adult; D000368:Aged; D001146:Arrhythmia, Sinus / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood*; D003324:Coronary Artery Disease / Q000175:diagnosis*; D016207:Cytokines / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D016207:Cytokines; D015850:Interleukin-6
keywords: Cytokines; Heart; Interleukin-6; Sinus arrhythmia