title: A comparison between conventional liposome and drug-cyclodextrin complex in liposome system.
abstract: A drug-cyclodextrin complex in liposome system was prepared in order to make a comparison with conventional risperidone-loaded liposome. Thin film hydration, reverse phase evaporation and ethanol injection methods were taken as preparation means to obtain the two types of liposome. Differential thermal analysis (DTA) and transmission electron microscopy (TEM) were used to investigate the thermal characters of inclusion complexes and morphology of liposome, respectively. Particle size, zeta potential and encapsulation efficiency were studied by light scattering analysis and ultrafiltration. In vitro release was carried out in the pH 7.4 phosphate buffer solution and samples were collected at the certain time. As a result, drug-cyclodextrin complex in liposome prepared by various methods displayed lower encapsulation efficiency than conventional liposome. However, size was larger and its stability was better than the latter. The second release phase of novel delivery system was slightly slower after initial burst release at the first phase, while the conventional liposome displayed a more regular trait. Thus, the novel liposome have potential to be developed as co-administration formulation with long-acting injection.
authors.affiliation: School of Pharmacy, Zhejiang University of Technology, Hangzhou 310014, China.
authors.forename: Wen-Xi
authors.initials: WX
authors.lastname: Wang
authors.affiliation: School of Pharmacy, Zhejiang University of Technology, Hangzhou 310014, China.
authors.forename: Shi-Sen
authors.initials: SS
authors.lastname: Feng
authors.affiliation: Women's Hospital School of Medicine Zhejiang University, Hangzhou 310006, China. Electronic address: chzheng@zju.edu.cn.
authors.forename: Cai-Hong
authors.initials: CH
authors.lastname: Zheng
mesh_terms: D003505:Cyclodextrins / Q000737:chemistry*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D004355:Drug Stability; D008081:Liposomes / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D010316:Particle Size; D018967:Risperidone / Q000737:chemistry*
chemical_list: D003505:Cyclodextrins; D008081:Liposomes; D018967:Risperidone
keywords: 6450536); Cholesterol (Pubchem CID: 5997); Comparison; Cyclodextrin; Glucose (Pubchem CID: 5793); Hydroxypropyl-beta-cyclodextrin (Pubchem CID: 14049689); Liposome; Risperidone; Risperidone (Pubchem CID: 5073); Soya phosphatidylcholine (Pubchem CID