title: Advanced Therapeutic Strategies for Chronic Lung Disease Using Nanoparticle-Based Drug Delivery.
abstract: Chronic lung diseases include a variety of obstinate and fatal diseases, including asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), idiopathic pulmonary fibrosis (IPF), and lung cancers. Pharmacotherapy is important for the treatment of chronic lung diseases, and current progress in nanoparticles offers great potential as an advanced strategy for drug delivery. Based on their biophysical properties, nanoparticles have shown improved pharmacokinetics of therapeutics and controlled drug delivery, gaining great attention. Herein, we will review the nanoparticle-based drug delivery system for the treatment of chronic lung diseases. Various types of nanoparticles will be introduced, and recent innovative efforts to utilize the nanoparticles as novel drug carriers for the effective treatment of chronic lung diseases will also be discussed.
authors.affiliation: Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA. jyheephd@umn.edu.
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Yhee
authors.affiliation: Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA. imxxx063@umn.edu.
authors.forename: Jintaek
authors.initials: J
authors.lastname: Im
authors.affiliation: Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA. nhoxx002@umn.edu.
authors.forename: Richard Seonghun
authors.initials: RS
authors.lastname: Nho
keywords: biodistribution; lung diseases; nanoparticle; pulmonary delivery; therapy