title: Challenges of Chronic Cardiac Problems in Survivors of Takotsubo Syndrome.
abstract: A hallmark feature of the Takotsubo syndrome (TTS) is the reversible nature of the observed cardiac dysfunction. This is underlined in diagnostic criteria. However, it would appear this reversibility is a subtle process, and that myocardial catecholamine toxicity can cause lasting permanent abnormalities of myocardial physiology. A growing body of evidence suggests persisting abnormalities may predispose post-TTS patients to cardiac and noncardiac morbidity and mortality. The cardiology community needs to understand more clearly how TTS evolves, how to identify high-risk patients with incomplete resolution, and perform studies to assess which treatment(s) are effective to improve cardiac recovery and clinical outcomes.
authors.affiliation: National Institute for Health Research Cardiovascular Biomedical Research Unit, Royal Brompton & Harefield NHS Foundation Trust, National Heart & Lung Institute, Imperial College London, London, UK; Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Morley-Smith
authors.affiliation: National Institute for Health Research Cardiovascular Biomedical Research Unit, Royal Brompton & Harefield NHS Foundation Trust, National Heart & Lung Institute, Imperial College London, London, UK; Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK. Electronic address: A.Lyon@imperial.ac.uk.
authors.forename: Alexander R
authors.initials: AR
authors.lastname: Lyon
mesh_terms: D002908:Chronic Disease; D006331:Heart Diseases / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D064887:Observational Studies as Topic; D011379:Prognosis; D011788:Quality of Life; D017741:Survivors; D054549:Takotsubo Cardiomyopathy / Q000150:complications / Q000503:physiopathology* / Q000523:psychology
keywords: Persistent; Psychology; Recurrence; Takotsubo