title: Identity Crisis: CD301b(+) Mononuclear Phagocytes Blur the M1-M2 Macrophage Line.
abstract: Obesity shifts the immune phenotype from M2 macrophage polarization to M1, which causes metabolic dysfunction. In this issue of Immunity, Kumamoto et al. (2016) identify a tissue-resident mononuclear phagocyte population that promotes weight gain and glucose intolerance but are defined by the M2 marker CD301b.
authors.affiliation: Department of Genetics and Complex Diseases, Division of Biological Sciences, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA.
authors.forename: Nelson H
authors.initials: NH
authors.lastname: Knudsen
authors.affiliation: Department of Genetics and Complex Diseases, Division of Biological Sciences, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA. Electronic address: clee@hsph.harvard.edu.
authors.forename: Chih-Hao
authors.initials: CH
authors.lastname: Lee
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D018149:Glucose Intolerance / Q000276:immunology; D006801:Humans; D037181:Lectins, C-Type / Q000276:immunology / Q000378:metabolism*; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism*; D010586:Phagocytes / Q000276:immunology* / Q000378:metabolism*; D015430:Weight Gain / Q000276:immunology
chemical_list: D015415:Biomarkers; D037181:Lectins, C-Type