title: IMMUNE CHANGES IN NEWBORN INFANTS WITH GASTROINTESTINAL FAILURE REQUIRING INTENSIVE CARE.
abstract: Newborns in critical conditions, because of the natureof the immune system, have the greatest risk of realization of immune deficiency, especially with gastrointestinal failure. We analyzed 44 cases of diseases in newborns in critical conditions and 20 cases without and studied the clinical and laboratory signs of immunological disorders, organpathology, gene expressionToll-likereceptor type 2. In newborns requiring intensive care, the frequency of gastrointestinal failure registration in 40,9%. Gastrointestinal failure leads to increased amounts of other affected systems, severity of systemic inflammation, gene expressionToll-likereceptor type 2, a marker of apoptosis of lymphocytes-CD95+, inhibition lymphocyte germ of immune system due to fraction of CD4+,the severity of the clinical condition. In newbornsin intensive care gastrointestinal failure is recorded at a frequency of 40,9%, is a component of multiple organ dysfunction syndrome, increases the expression of the geneToll-likereceptor type 2, implements violation adequate response humoral immunity, activates apoptosis of lymphocytes, which increases the severity of the patients.
authors.affiliation: Higher State Educational Institution of Ukraine "Ukrainian Medical Stomatological Academy", Poltava, Ukraine.
authors.forename: D
authors.initials: D
authors.lastname: Kholod
authors.affiliation: Higher State Educational Institution of Ukraine "Ukrainian Medical Stomatological Academy", Poltava, Ukraine.
authors.forename: D
authors.initials: D
authors.lastname: Shkurupii
authors.affiliation: Higher State Educational Institution of Ukraine "Ukrainian Medical Stomatological Academy", Poltava, Ukraine.
authors.forename: E
authors.initials: E
authors.lastname: Sonnik
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000473:pathology; D003422:Critical Care; D005767:Gastrointestinal Diseases / Q000209:etiology / Q000276:immunology*; D006801:Humans; D007231:Infant, Newborn; D018655:Lymphocyte Count; D009102:Multiple Organ Failure / Q000209:etiology / Q000276:immunology; D018805:Sepsis / Q000150:complications / Q000276:immunology; D051195:Toll-Like Receptor 2 / Q000378:metabolism; D019014:fas Receptor / Q000378:metabolism
chemical_list: C491901:FAS protein, human; D051195:Toll-Like Receptor 2; D019014:fas Receptor