title: A Virus-Like Particle Vaccine Elicits Broad Neutralizing Antibody Responses in Humans to All Chikungunya Virus Genotypes.
abstract: Chikungunya virus (CHIKV) is an alphavirus that has emerged as a global health burden. There are 3 CHIKV genotypes: Asian, West African, and Eastern/Central/South African. No licensed CHIKV vaccine is available, and whether the antibody response elicited by one genotype can neutralize heterologous genotypes is unclear. We assessed neutralizing antibody (NAb) responses of volunteers in a phase 1 study of a CHIKV vaccine against 9 viral strains representing all 3 genotypes. Minimal differences in vaccine-elicited NAb responses were observed among genotypes, suggesting that vaccination with a single CHIKV strain can elicit cross-protective NAbs against all 3 genotypes.
authors.affiliation: Viral Pathogenesis Section, Laboratory of Viral Diseases.
authors.forename: Leslie
authors.initials: L
authors.lastname: Goo
authors.affiliation: Viral Pathogenesis Section, Laboratory of Viral Diseases.
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Dowd
authors.affiliation: Viral Pathogenesis Section, Laboratory of Viral Diseases.
authors.forename: Tsai-Yu
authors.initials: TY
authors.lastname: Lin
authors.affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
authors.forename: John R
authors.initials: JR
authors.lastname: Mascola
authors.affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
authors.forename: Barney S
authors.initials: BS
authors.lastname: Graham
authors.affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
authors.forename: Julie E
authors.initials: JE
authors.lastname: Ledgerwood
authors.affiliation: Viral Pathogenesis Section, Laboratory of Viral Diseases.
authors.forename: Theodore C
authors.initials: TC
authors.lastname: Pierson
mesh_terms: D057134:Antibodies, Neutralizing / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood*; D065632:Chikungunya Fever / Q000517:prevention & control*; D002646:Chikungunya virus / Q000145:classification / Q000276:immunology*; D056738:Cross Protection; D003429:Cross Reactions; D005838:Genotype; D006801:Humans; D009500:Neutralization Tests; D058425:Vaccines, Virus-Like Particle / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D058425:Vaccines, Virus-Like Particle
keywords: chikungunya virus; neutralizing antibodies; virus-like particle vaccine