title: Complete Genome Sequence of the MRSA Isolate HC1335 from ST239 Lineage Displaying a Truncated AgrC Histidine Kinase Receptor.
abstract: Methicillin-resistant Staphylococcus aureus (MRSA) is still one of the most important hospital pathogen globally. The multiresistant isolates of the ST239-SCCmecIII lineage are spread over large geographic regions, colonizing and infecting hospital patients in virtually all continents. The balance between fitness (adaptability) and virulence potential is likely to represent an important issue in the clonal shift dynamics leading the success of some specific MRSA clones over another. The accessory gene regulator (agr) is the master quorum sensing system of staphylococci playing a role in the global regulation of key virulence factors. Consequently, agr inactivation in S. aureus may represent a significant mechanism of genetic variability in the adaptation of this healthcare-associated pathogen. We report here the complete genome sequence of the methicillin-resistant S. aureus, isolate HC1335, a variant of the ST239 lineage, which presents a natural insertion of an IS256 transposase element in the agrC gene encoding AgrC histidine kinase receptor.
authors.affiliation: Laboratório de Biologia Molecular de Bactérias, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Ana M N
authors.initials: AM
authors.lastname: Botelho
authors.affiliation: Laboratório Nacional de Computação Científica, Petrópolis, Brazil.
authors.forename: Maiana O C
authors.initials: MO
authors.lastname: Costa
authors.affiliation: Laboratório de Biologia Molecular de Bactérias, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Cristiana O
authors.initials: CO
authors.lastname: Beltrame
authors.affiliation: Laboratório de Biologia Molecular de Bactérias, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Fabienne A
authors.initials: FA
authors.lastname: Ferreira
authors.affiliation: Laboratório Nacional de Computação Científica, Petrópolis, Brazil.
authors.forename: Nicholas C B
authors.initials: NC
authors.lastname: Lima
authors.affiliation: Laboratório de Biologia Molecular de Bactérias, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Bruno S S
authors.initials: BS
authors.lastname: Costa
authors.affiliation: Laboratório Nacional de Computação Científica, Petrópolis, Brazil.
authors.forename: Guilherme L
authors.initials: GL
authors.lastname: de Morais
authors.affiliation: Laboratório Nacional de Computação Científica, Petrópolis, Brazil.
authors.forename: Rangel C
authors.initials: RC
authors.lastname: Souza
authors.affiliation: Laboratório Nacional de Computação Científica, Petrópolis, Brazil.
authors.forename: Luiz G P
authors.initials: LG
authors.lastname: Almeida
authors.affiliation: Laboratório Nacional de Computação Científica, Petrópolis, Brazil.
authors.forename: Ana T R
authors.initials: AT
authors.lastname: Vasconcelos
authors.affiliation: Laboratório Nacional de Computação Científica, Petrópolis, Brazil.
authors.forename: Marisa F
authors.initials: MF
authors.lastname: Nicolás
authors.affiliation: Laboratório de Biologia Molecular de Bactérias, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil agnes@micro.ufrj.br.
authors.forename: Agnes M S
authors.initials: AM
authors.lastname: Figueiredo
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics*; D004251:DNA Transposable Elements; D056084:Genetic Fitness; D014644:Genetic Variation; D016680:Genome, Bacterial; D055624:Methicillin-Resistant Staphylococcus aureus / Q000235:genetics*; D016254:Mutagenesis, Insertional; D011494:Protein Kinases / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D004251:DNA Transposable Elements; D011494:Protein Kinases; C531166:AgrC protein, Staphylococcus
keywords: IS256 insertion; ST239 lineage; agrC dysfunction; complete genome sequence; methicillin-resistant Staphylococcus aureus