title: Evaluation of p27 Expression in Salivary Gland Neoplasms; A Step Forward in Unveiling the Role of p27.
abstract: BACKGROUND
  Salivary gland neoplasms are not uncommon lesions that are seen in the head and neck region. The role of cell cycle regulators as well as that of oncogenes remains unexplored in the pathogenesis of these neoplasms.
  
  
  OBJECTIVE
  Present study was conducted to evaluate the expression of p27 in the three common salivary gland neoplasms.
  
  
  METHODS
  A total of 34 cases (19 pleomorphic adenoma, 8 mucoepidermoid carcinoma and 7 adenoid cystic carcinoma) were included. The sections were subjected to p27 staining and rated for the expression.
  
  
  RESULTS
  Of the total 52.6% of pleomorphic adenoma cases, 25% of mucoepidermoid carcinoma cases and only 14.2% of adenoid cystic carcinoma cases showed strong expression suggesting variable p27 expression in both malignant neoplasms. Normal salivary gland tissue was stained as a positive control for the evaluation.
  
  
  CONCLUSIONS
  The results of the study suggest an important role for p27 in pathogenesis of mucoepidermoid carcinoma as well as adenoid cystic carcinoma while its role in pathogenesis of pleomorphic adenoma remains questionable keeping in view the strong expression of p27 in the same.
authors.affiliation: Faculty, Department of Oral Medicine and Diagnostic Sciences, Al Farabi Colleges , Riyadh, Saudi Arabia .
authors.forename: Nikhil I
authors.initials: NI
authors.lastname: Malgaonkar
authors.affiliation: Faculty, Department of Basic Medical Sciences, College of Medicine, Prince Stam Bin Abdulaziz university .
authors.forename: Abdulwahab
authors.initials: A
authors.lastname: Abuderman
authors.affiliation: Faculty, Department of Oral Maxillofacial Surgery, Al-Farabi Colleges, Aleppo University , Jeddah, Kingdom of Saudi Arabia .
authors.forename: M Y
authors.initials: MY
authors.lastname: Kharma
authors.affiliation: Faculty, Department of Oral Medicine and Diagnostic Sciences, Al Farabi Colleges , Riyadh, Saudi Arabia .
authors.forename: S A
authors.initials: SA
authors.lastname: Al-Maweri
authors.affiliation: Faculty, Department of Oral Medicine and Diagnostic Sciences, Al Farabi Colleges , Riyadh, Saudi Arabia .
authors.forename: N A
authors.initials: NA
authors.lastname: Alaizari
authors.affiliation: Faculty, Department of Oral Medicine and Diagnostic Sciences, Al Farabi Colleges , Riyadh, Saudi Arabia .
authors.forename: Ma
authors.initials: M
authors.lastname: Altamimi
authors.affiliation: Faculty, Department of Oral Medicine and Diagnostic Sciences, Al Farabi Colleges , Riyadh, Saudi Arabia .
authors.forename: S
authors.initials: S
authors.lastname: Darwish
authors.affiliation: Faculty, Department of Oral Medicine and Diagnostic Sciences, Al Farabi Colleges , Riyadh, Saudi Arabia .
authors.forename: Bassel
authors.initials: B
authors.lastname: Tarakji
keywords: Adenoid cystic carcinomas; Cyclin dependent kinase inhibitor; Mucoepidermoid carcinomas; Pleomorphic adenomas