title: Artefactual origin of biphasic cortical spike-LFP correlation.
abstract: Electrophysiological data acquisition systems introduce various distortions into the signals they record. While such distortions were discussed previously, their effects are often not appreciated. Here I show that the biphasic shape of cortical spike-triggered LFP average (stLFP), reported in multiple studies, is likely an artefact introduced by high-pass filter of the neural data acquisition system when the actual stLFP has a single trough around the zero lag.
authors.affiliation: Department of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester, LE1 9HN, UK. mo178@le.ac.uk.|Centre for Systems Neuroscience, University of Leicester, Leicester, LE1 7QR, UK. mo178@le.ac.uk.|Institute of Neurology, University College London, WC1N 3BG, London, UK. mo178@le.ac.uk.|Department of Neuroscience, Physiology and Pharmacology, University College London, WC1E 6DE, London, UK. mo178@le.ac.uk.|Institute of Ophthalmology, University College London, EC1V 9EL, London, UK. mo178@le.ac.uk.
authors.forename: Michael
authors.initials: M
authors.lastname: Okun
mesh_terms: D016477:Artifacts; D002540:Cerebral Cortex / Q000502:physiology; D055724:Electrophysiological Phenomena; D006801:Humans; D008959:Models, Neurological
keywords: Extracellular amplifier; Neural data acquisition; Neural probes; Phase distortion; Silicon probes