title: Tailoring biomaterial surface properties to modulate host-implant interactions: implication in cardiovascular and bone therapy.
abstract: Host body response to a foreign medical device plays a critical role in defining its fate post implantation. It is thus important to control host-material interactions by designing innovative implant surfaces. In the recent years, biochemical and topographical features have been explored as main target to produce this new type of bioinert or bioresponsive implants. The review discusses specific biofunctional materials and strategies to achieve a precise control over implant surface properties and presents possible solutions to develop next generation of implants, particularly in the fields of bone and cardiovascular therapy.
authors.affiliation: BioIntel Research Laboratory, Department of Chemical and Petroleum Engineering, Bioengineering Graduate Program, School of Engineering, University of Kansas, Lawrence, KS, USA.
authors.forename: Settimio
authors.initials: S
authors.lastname: Pacelli
authors.affiliation: BioIntel Research Laboratory, Department of Chemical and Petroleum Engineering, Bioengineering Graduate Program, School of Engineering, University of Kansas, Lawrence, KS, USA.
authors.forename: Vijayan
authors.initials: V
authors.lastname: Manoharan
authors.affiliation: University of Southampton, School of Medicine, University Road, Southampton SO17 1BJ, United Kingdom.
authors.forename: Anna
authors.initials: A
authors.lastname: Desalvo
authors.affiliation: Biomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering, Faculty of Medicine, Duff Medical Building, 3775 University Street, McGill University, QC, Canada H3A 2B4.
authors.forename: Nikita
authors.initials: N
authors.lastname: Lomis
authors.affiliation: BioIntel Research Laboratory, Department of Chemical and Petroleum Engineering, Bioengineering Graduate Program, School of Engineering, University of Kansas, Lawrence, KS, USA.
authors.forename: Kartikeya Singh
authors.initials: KS
authors.lastname: Jodha
authors.affiliation: Biomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering, Faculty of Medicine, Duff Medical Building, 3775 University Street, McGill University, QC, Canada H3A 2B4.
authors.forename: Satya
authors.initials: S
authors.lastname: Prakash
authors.affiliation: BioIntel Research Laboratory, Department of Chemical and Petroleum Engineering, Bioengineering Graduate Program, School of Engineering, University of Kansas, Lawrence, KS, USA.
authors.forename: Arghya
authors.initials: A
authors.lastname: Paul