title: Copper-Catalyzed Regio- and Stereoselective Aminoboration of Alkenylboronates.
abstract: A copper-catalyzed aminoboration of alkenyl dan boronates (dan = 1,8-diaminonaphthyl) with diboron reagents and hydroxylamines has been developed. The reaction proceeds regio- and stereoselectively to form the corresponding β-boryl-α-aminoboronic acid derivatives of potent interest in medicinal chemistry. Additionally, the ligand-controlled syn/anti diastereoselectivity switching and preliminary asymmetric catalysis are also described.
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Osaka University , Suita, Osaka 565-0871, Japan.
authors.forename: Daiki
authors.initials: D
authors.lastname: Nishikawa
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Osaka University , Suita, Osaka 565-0871, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Hirano
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Osaka University , Suita, Osaka 565-0871, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Miura