title: The Impact of Cognitive Training on Cerebral White Matter in Community-Dwelling Elderly: One-Year Prospective Longitudinal Diffusion Tensor Imaging Study.
abstract: It has been shown that cognitive training (CogTr) is effective and recuperative for older adults, and can be used to fight against cognitive decline. In this study, we investigated whether behavioural gains from CogTr would extend to white matter (WM) microstructure, and whether training-induced changes in WM integrity would be associated with improvements in cognitive function, using diffusion tensor imaging (DTI). 48 healthy community elderly were either assigned to multi-domain or single-domain CogTr groups to receive 24 sessions over 12 weeks, or to a control group. DTI was performed at both baseline and 12-month follow-up. Positive effects of multi-domain CogTr on long-term changes in DTI indices were found in posterior parietal WM. Participants in the multi-domain group showed a trend of long-term decrease in axial diffusivity (AD) without significant change in fractional anisotropy (FA), mean diffusivity (MD) or radial diffusivity (RD), while those in the control group displayed a significant FA decrease, and an increase in MD and RD. In addition, significant relationships between an improvement in processing speed and changes in RD, MD and AD were found in the multi-domain group. These findings support the hypothesis that plasticity of WM can be modified by CogTr, even in late adulthood.
authors.affiliation: Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
authors.forename: Xinyi
authors.initials: X
authors.lastname: Cao
authors.affiliation: Institute of Science and Technology for Brain-Inspired Intellegence, Fudan University, Shanghai, 200433, China.|Department of Computer Science, University of Warwick, Coventry CV4 7AL, UK.
authors.forename: Ye
authors.initials: Y
authors.lastname: Yao
authors.affiliation: Shanghai Changning Mental Health Center, Shanghai, 200335, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Li
authors.affiliation: Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Department of Psychiatry, Tongji Hospital of Tongji University, Shanghai, 200065, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Feng
authors.affiliation: Department of Psychiatry, Tenth People's Hospital of Tongji University, Shanghai, 200072, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Psychiatry, Tongji Hospital of Tongji University, Shanghai, 200065, China.
authors.forename: Qingwei
authors.initials: Q
authors.lastname: Li
authors.affiliation: Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Department of Psychiatry, Tongji Hospital of Tongji University, Shanghai, 200065, China.
authors.forename: Wenyuan
authors.initials: W
authors.lastname: Wu
authors.affiliation: Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
authors.forename: Jijun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Sheng
authors.affiliation: Institute of Science and Technology for Brain-Inspired Intellegence, Fudan University, Shanghai, 200433, China.|Department of Computer Science, University of Warwick, Coventry CV4 7AL, UK.|Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, 200433, China.|Shanghai Center for Mathematical Sciences, Shanghai, 200433, China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Feng
authors.affiliation: Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.|Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, 200030, China.|Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, 200030, China.
authors.forename: Chunbo
authors.initials: C
authors.lastname: Li
mesh_terms: D000368:Aged; D003071:Cognition / Q000502:physiology*; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D057187:Independent Living; D008137:Longitudinal Studies; D008297:Male; D009483:Neuropsychological Tests; D011446:Prospective Studies; D013997:Time Factors; D066127:White Matter / Q000000981:diagnostic imaging* / Q000503:physiopathology