title: Vasopressin receptor antagonists in patients with chronic heart failure.
abstract: In this brief review, the pathophysiology of hyponatremia and its clinical significance in the course of chronic heart failure (CHF) are illustrated. Moreover, issues concerning the optimal treatment for hyponatremia during CHF are addressed and discussed. In addition, advantages and limitations resulting from the use of vasopressin receptor antagonists, drugs that have recently emerged as the best available resource against hyponatremia, are highlighted.
authors.affiliation: Cardiology Unit, Presidio Sanitario Intermedio "Elena d'Aosta", ASL Napoli 1 Centro, Naples, Italy. devecchis.erre@virgilio.it.
authors.forename: R
authors.initials: R
authors.lastname: De Vecchis
authors.affiliation: Cardiology Unit, Presidio Sanitario Intermedio "Elena d'Aosta", ASL Napoli 1 Centro, Naples, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Cantatrione
authors.affiliation: Cardiology Unit, Presidio Sanitario Intermedio "Elena d'Aosta", ASL Napoli 1 Centro, Naples, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Mazzei
mesh_terms: D065092:Antidiuretic Hormone Receptor Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D001127:Arginine Vasopressin / Q000097:blood; D002908:Chronic Disease; D045604:Extracellular Fluid / Q000187:drug effects / Q000502:physiology; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007010:Hyponatremia / Q000188:drug therapy / Q000503:physiopathology; D012964:Sodium / Q000097:blood; D014882:Water-Electrolyte Balance / Q000187:drug effects / Q000502:physiology
chemical_list: D065092:Antidiuretic Hormone Receptor Antagonists; D001127:Arginine Vasopressin; D012964:Sodium
keywords: Antidiuretic hormone receptor antagonist; Heart failure; Hyponatremia; Hypovolemia; Sodium