title: Utilization of PET imaging in differential diagnostics between a tumefactive multiple sclerosis lesion and low-grade glioma.
abstract: We present a case where a 30-year-old man with a history of combined MS and Charcot-Marie-Tooth (CMT I) disease was additionally diagnosed and treated for grade II glioma (astrocytoma). Tumefactive MS and gliomas are sometimes difficult to distinguish from one another based on conventional magnetic resonance imaging (MRI). In our case, positron emission tomography (PET) scans with(11)C-methionine ((11)C-MET) and (11)C-PK11195 radioligands were performed to aid in differential diagnostics. The diagnosis was confirmed finally by brain biopsy. The usefulness of PET imaging in differential diagnostics between tumefactive MS and glioma is discussed.
authors.affiliation: Division of Clinical Neurosciences, Turku University Hospital and University of Turku, Turku, Finland. Electronic address: aleksi.tarkkonen@utu.fi.
authors.forename: Aleksi
authors.initials: A
authors.lastname: Tarkkonen
authors.affiliation: Division of Clinical Neurosciences, Turku University Hospital and University of Turku, Turku, Finland; Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland.
authors.forename: Eero
authors.initials: E
authors.lastname: Rissanen
authors.affiliation: Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland.
authors.forename: Terhi
authors.initials: T
authors.lastname: Tuokkola
authors.affiliation: Division of Clinical Neurosciences, Turku University Hospital and University of Turku, Turku, Finland; Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland.
authors.forename: Laura
authors.initials: L
authors.lastname: Airas
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D002607:Charcot-Marie-Tooth Disease / Q000150:complications / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D005910:Glioma / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000150:complications / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography
keywords: Glioma; Multiple sclerosis; PET; TSPO