title: Equine Pulmonary Cryptococcosis: A Comparative Literature Review and Evaluation of Fluconazole Monotherapy.
abstract: Cryptococcus is the most common fungal respiratory pathogen in Australian horses, manifesting primarily as pulmonary granulomas. Disease severity at presentation is dependent on the athletic use of the horse. The diagnosis and estimation of disease severity are centred around clinical findings, cytological evaluation of respiratory tract secretions, diagnostic imaging, and antigen titre testing. Both the lateral flow assay and the latex cryptococcal antigen titre are used, and important similarities and differences between species are discussed. Cryptococcus gattii occurs with greater frequency than Cryptococcus neoformans in equine pulmonic cryptococcosis and can be successfully treated with enteral fluconazole monotherapy, with disease severity determining treatment length.
authors.affiliation: College of Veterinary Medicine, School of Veterinary and Life Sciences, Murdoch University, South Street, Murdoch, WA, 6150, Australia. csecombe@murdoch.edu.au.
authors.forename: C J
authors.initials: CJ
authors.lastname: Secombe
authors.affiliation: College of Veterinary Medicine, School of Veterinary and Life Sciences, Murdoch University, South Street, Murdoch, WA, 6150, Australia.
authors.forename: G D
authors.initials: GD
authors.lastname: Lester
authors.affiliation: Faculty of Veterinary Science, University of Sydney, Sydney, NSW, 2006, Australia.
authors.forename: M B
authors.initials: MB
authors.lastname: Krockenberger
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D003453:Cryptococcosis / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D003454:Cryptococcus / Q000302:isolation & purification*; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D006734:Horse Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology*; D006736:Horses; D008172:Lung Diseases, Fungal / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D008297:Male; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole
keywords: Antigen titre; Cryptococcosis; Cryptococcus gattii; Cryptococcus gattii/Cryptococcus neoformans species complex; Cryptococcus neoformans; Equine; Horse; Pulmonic