title: Prenylated Coumarins from Heracleum stenopterum, Peucedanum praeruptorum, Clausena lansium, and Murraya paniculata.
abstract: Four hitherto unknown prenylated coumarins, namely 6″-O-β-D-apiofuranosylapterin (1), 4'-O-isobutyroylpeguangxienin (2), 6-(3-methyl-2-oxobutyroyl)-7-methoxycoumarin (3), and 6-hydroxycoumurrayin (4), were isolated from the ethanol extract of Heracleum stenopterum, Peucedanum praeruptorum, Clausena lansium, and Murraya paniculata, respectively. Their chemical structures were established on the basis of extensive spectroscopic analysis. Compound 2 exhibited in vitro cytotoxic activity against five human cancer cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW-480) with IC50values ranging from 15.9 to 23.2 μM.
authors.affiliation: BioBioPha Co., Ltd., Kunming, 650201, People's Republic of China.
authors.forename: Xiang-Mei
authors.initials: XM
authors.lastname: Li
authors.affiliation: BioBioPha Co., Ltd., Kunming, 650201, People's Republic of China.
authors.forename: Xian-Jun
authors.initials: XJ
authors.lastname: Jiang
authors.affiliation: BioBioPha Co., Ltd., Kunming, 650201, People's Republic of China.
authors.forename: Ku
authors.initials: K
authors.lastname: Yang
authors.affiliation: BioBioPha Co., Ltd., Kunming, 650201, People's Republic of China.
authors.forename: Li-Xia
authors.initials: LX
authors.lastname: Wang
authors.affiliation: BioBioPha Co., Ltd., Kunming, 650201, People's Republic of China.
authors.forename: Shi-Zhen
authors.initials: SZ
authors.lastname: Wen
authors.affiliation: BioBioPha Co., Ltd., Kunming, 650201, People's Republic of China. f.wang@mail.biobiopha.com.
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
keywords: Clausena lansium; Cytotoxicity; Heracleum stenopterum; Murraya paniculata; Peucedanum praeruptorum; Prenylated coumarin