title: [The expression of TLR4 and HBD3 in epithelial cells of oral mucosa by surgical treatment of periodontitis].
abstract: The expression of TLR4 and HBD3 in epithelial cells of the oral cavity was studied using polymerase chain reaction in real-time in patients with inflammatory and destructive periodontal lesions before and after surgery using osteoplastic material. Analysis of TLR4 and HBD3 expression in epithelial cells demonstrates the key role of the innate immune factors in the pathogenesis of inflammatory and destructive periodontal lesions. TLR4 gene expression was increased 1.5-7.0 times and HBD3 1.5-5.0 times compared to healthy individuals. Surgical treatment resulted in an effective rehabilitation and normalization of innate immunity.
authors.affiliation: Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia; I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Zorina
authors.affiliation: N. Pirogov's Russian National Research Medical University, Moskow, Russia.
authors.forename: L V
authors.initials: LV
authors.lastname: Gankovskaya
authors.affiliation: Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia.
authors.forename: R A
authors.initials: RA
authors.lastname: Balykin
authors.affiliation: I.M. Sechenov First Moscow State Medical University, Moscow, Russia; N. Pirogov's Russian National Research Medical University, Moskow, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Svitich
authors.affiliation: I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: T P
authors.initials: TP
authors.lastname: Ivanyushko
mesh_terms: D000328:Adult; D004847:Epithelial Cells / Q000276:immunology; D005260:Female; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000276:immunology*; D010518:Periodontitis / Q000235:genetics / Q000276:immunology* / Q000601:surgery*; D060888:Real-Time Polymerase Chain Reaction; D051197:Toll-Like Receptor 4 / Q000235:genetics*; D023083:beta-Defensins / Q000235:genetics*
chemical_list: C422950:DEFB103A protein, human; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4; D023083:beta-Defensins