title: Effects of a single, oral 60 mg caffeine dose on attention in healthy adult subjects.
abstract: Caffeine induces positive effects on sustained attention, although studies assessing the acute effects of low caffeine dose (<75 mg) on sustained attention are limited and use short-term tests. Therefore, we investigated the acute effects of a 60 mg dose of caffeine on sustained attention in tests lasting up to 45 minutes using 82 low or non-caffeine-consuming healthy male ( n=41) and female ( n=41) adults aged between 40 and 60 years. Vigilance was measured using Mackworth Clock test, Rapid Visual Information Processing Test, adaptive tracking test, saccadic eye movement and attention switch test. Effects on mood and fatigue were analysed using Bond and Lader and Caffeine Research visual analogue scales, and Samn-Perelli questionnaire. Saliva sampling was performed for both compliance and caffeine pharmacokinetic analysis. Administration of a 60 mg caffeine dose resulted in a significant improvement in sustained attention compared with the placebo. Also a significantly improved peak saccadic velocity and reaction time performance was found, and decreased error rate. Significantly increased feelings of alertness, contentment and overall mood after caffeine treatment compared with placebo were observed. This study demonstrated that in healthy adult subjects oral administration of a single 60 mg caffeine dose elicited a clear enhancement of sustained attention and alertness, measured both in multiple objective performances and in subjective scales.
authors.affiliation: 1 Centre for Human Drug Research (CHDR), Leiden, the Netherlands.|3 Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam, the Netherlands.
authors.forename: Micha Mm
authors.initials: MM
authors.lastname: Wilhelmus
authors.affiliation: 1 Centre for Human Drug Research (CHDR), Leiden, the Netherlands.
authors.forename: Justin L
authors.initials: JL
authors.lastname: Hay
authors.affiliation: 1 Centre for Human Drug Research (CHDR), Leiden, the Netherlands.
authors.forename: Rob Gja
authors.initials: RG
authors.lastname: Zuiker
authors.affiliation: 1 Centre for Human Drug Research (CHDR), Leiden, the Netherlands.
authors.forename: Pieter
authors.initials: P
authors.lastname: Okkerse
authors.affiliation: 2 Nestle Research Centre, Lausanne, Switzerland.
authors.forename: Christelle
authors.initials: C
authors.lastname: Perdrieu
authors.affiliation: 2 Nestle Research Centre, Lausanne, Switzerland.
authors.forename: Julien
authors.initials: J
authors.lastname: Sauser
authors.affiliation: 2 Nestle Research Centre, Lausanne, Switzerland.
authors.forename: Maurice
authors.initials: M
authors.lastname: Beaumont
authors.affiliation: 2 Nestle Research Centre, Lausanne, Switzerland.
authors.forename: Jeroen
authors.initials: J
authors.lastname: Schmitt
authors.affiliation: 1 Centre for Human Drug Research (CHDR), Leiden, the Netherlands.
authors.forename: Joop Ma
authors.initials: JM
authors.lastname: van Gerven
authors.affiliation: 2 Nestle Research Centre, Lausanne, Switzerland.
authors.forename: Beata Y
authors.initials: BY
authors.lastname: Silber
mesh_terms: D000328:Adult; D000339:Affect / Q000187:drug effects; D001288:Attention / Q000187:drug effects*; D002110:Caffeine / Q000008:administration & dosage* / Q000493:pharmacokinetics; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005221:Fatigue / Q000503:physiopathology; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D011597:Psychomotor Performance / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D012463:Saliva / Q000378:metabolism
chemical_list: D002110:Caffeine
keywords: Caffeine; alertness; mood; sustained attention tests