title: Antioxidant Potential and DNA Damage Protection by the Slate Grey Saddle Mushroom, Helvella lacunosa (Ascomycetes), from Kashmir Himalaya (India).
abstract: This study pertains to the radical scavenging potential of and DNA protection by Helvella lacunosa, an edible mushroom from Kashmir Himalaya (India). Different solvents, on the basis of their polarities, were used to extract all solvent-soluble bioactive compounds. Seven different antioxidant methods were also used to determine extensive radical scavenging activity. The mushroom ethanol extract and butanol extract showed effective scavenging activity of radicals at 95% and 89%, respectively. At 800 µg/mg, the ethanol extract was potent enough to protect DNA from degradation by hydroxyl radicals. It is evident from these findings that the presence of antioxidant substances signifies the use of H. lacunosa as food in the mountainous valleys of the Himalayan region.
authors.affiliation: Centre of Research for Development, University of Kashmir, Srinagar, Jammu and Kashmir, India.
authors.forename: Nowsheen
authors.initials: N
authors.lastname: Shameem
authors.affiliation: Centre of Research for Development, University of Kashmir, Srinagar, Jammu and Kashmir, India.
authors.forename: Azra N
authors.initials: AN
authors.lastname: Kamili
authors.affiliation: SKUAST-K, Shalimar Srinagar, Jammu and Kashmir, India.
authors.forename: Mushtaq
authors.initials: M
authors.lastname: Ahmad
authors.forename: F A
authors.initials: FA
authors.lastname: Masoodi
authors.affiliation: Centre of Research for Development, University of Kashmir, Srinagar, Jammu and Kashmir, India.
authors.forename: Javid A
authors.initials: JA
authors.lastname: Parray
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D001713:Biphenyl Compounds; D004249:DNA Damage / Q000187:drug effects*; D048690:Fruiting Bodies, Fungal / Q000737:chemistry*; D010851:Picrates; D013482:Superoxide Dismutase
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl; D013482:Superoxide Dismutase