title: Epigenetic regulation of axonal regenerative capacity.
abstract: The intrinsic growth capacity of neurons in the CNS declines during neuronal maturation, while neurons in the adult PNS are capable of regeneration. Injured mature PNS neurons require activation of an array of regeneration-associated genes to regain axonal growth competence. Accumulating evidence indicates a pivotal role of epigenetic mechanisms in transcriptional reprogramming and regulation of neuronal growth ability upon injury. In this review, we summarize the latest findings implicating epigenetic mechanisms, including histone and DNA modifications, in axon regeneration and discuss differential epigenomic configurations between neurons in the adult mammalian CNS and PNS.
authors.affiliation: Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.|Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Yi-Lan
authors.initials: YL
authors.lastname: Weng
authors.affiliation: Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.|Graduate Program in Cellular & Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Jessica
authors.initials: J
authors.lastname: Joseph
authors.affiliation: Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.|Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Ran
authors.initials: R
authors.lastname: An
authors.affiliation: Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.|Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.|Graduate Program in Cellular & Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.|The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Song
authors.affiliation: Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.|Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.|Graduate Program in Cellular & Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.|The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.|Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Guo-Li
authors.initials: GL
authors.lastname: Ming
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D004247:DNA / Q000378:metabolism; D044127:Epigenesis, Genetic; D042421:Histone Code; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D009416:Nerve Regeneration / Q000235:genetics*
chemical_list: D035683:MicroRNAs; D004247:DNA
keywords: DNA demethylation; DNA methylation; DNA methyltransferase; HDAC; TET family protein; axon regeneration; histone deacetylase inhibitor; histone modification