title: Ameliorative effect of synthetic γ-aminobutyric acid (GABA) on performance traits, antioxidant status and immune response in broiler exposed to cyclic heat stress.
abstract: The aim of this study was to find the effect of synthetic γ-aminobutyric acid (GABA) on the performance, antioxidant status, and immune response in broiler exposed to summer stress. A total of 400-day-old male broiler chickens (Ross 308) was randomly distributed into five treatments (5 replicates). One group served as a control (basal diet only) while the others were supplemented with GABA at the rate of 25 (GABA-25), 50 (GABA 50), 75 (GABA-75), and 100 (GABA-100) mg/kg feed. The experiment was continued for 35 days. Feed intake during the third week was significantly higher (P < 0.05) in GABA-75 and GABA-100, however, it increased significantly (P < 0.05) in GABA-100 during the fourth and fifth week. Overall mean feed intake was significantly (P < 0.05) high in GABA-75 and GABA-100. From the results, we found that body weight improved significantly (P < 0.05) in GABA-50 in week-3. During the fourth, fifth, and overall, body weight increased significantly (P < 0.05) in GABA-100. Significantly, high (P < 0.05) feed conversion ratio (FCR) was found in GABA-100 during the third, fourth, fifth, and on an overall basis. Mean Malondialdehyde (MDA) decreased significantly (P < 0.05) in GABA-100 while Paraoxonase (PON1) and Newcastle disease (ND) titer increased significantly (P < 0.05) in the same group. We concluded that performance traits, antioxidant status, and immune response improved in broiler supplemented 100 mg/kg GABA, exposed to cyclic heat stress.
authors.affiliation: Faculty of Animal Husbandry & Veterinary Sciences, The University of Agriculture, Peshawar, Pakistan.
authors.forename: Naila
authors.initials: N
authors.lastname: Chand
authors.affiliation: Faculty of Animal Husbandry & Veterinary Sciences, The University of Agriculture, Peshawar, Pakistan.
authors.forename: Sher
authors.initials: S
authors.lastname: Muhammad
authors.affiliation: Faculty of Animal Husbandry & Veterinary Sciences, The University of Agriculture, Peshawar, Pakistan. rifatullahkhhan@gmail.com.|Department of Animal production, College of Food and Agriculture Sciences, King Saud University, P.O. Box 2460, Riyadh, 11451, Saudi Arabia. rifatullahkhhan@gmail.com.
authors.forename: Rifat Ullah
authors.initials: RU
authors.lastname: Khan
authors.affiliation: Department of Animal production, College of Food and Agriculture Sciences, King Saud University, P.O. Box 2460, Riyadh, 11451, Saudi Arabia.
authors.forename: Ibrahim Abdullah
authors.initials: IA
authors.lastname: Alhidary
authors.affiliation: Faculty of Animal Husbandry & Veterinary Sciences, The University of Agriculture, Peshawar, Pakistan.
authors.forename: Zia Ur
authors.initials: ZU
authors.lastname: Rehman
mesh_terms: D000821:Animal Feed / Q000032:analysis; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D002645:Chickens / Q000276:immunology* / Q000378:metabolism*; D019587:Dietary Supplements; D006358:Hot Temperature; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D013312:Stress, Physiological / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D008315:Malondialdehyde; D005680:gamma-Aminobutyric Acid
keywords: Broiler; Gamma aminobutyric acid; Heat stress; Immunity; Performance