title: Cerebral Venous Thrombosis.
abstract: Cerebral venous thrombosis is an important cause of stroke in the young. Unlike venous thromboembolism (VTE), women are affected three times more often than men by CVT. The most common symptoms are headache, seizures and focal neurological deficits. The diagnosis can be confirmed with MRI, CT-venography, or catheter angiography. An intracerebral hemorrhage is found on cerebral imaging in approximately 40 % of patients, and can range from small juxtacortical hemorrhages to large space-occupying lesions. Many risk factors for CVT have been reported, most of which overlap with those of VTE. The primary therapy for CVT is anticoagulation with heparin, based on limited evidence from randomized trials. Both unfractionated or low-molecular weight heparin can be used to treat CVT, although the latter is generally preferable. Small studies have shown promising results of endovascular treatment in severe patients, but these data require confirmation in a randomized trial. In patients who develop clinical and radiological signs of impending herniation decompressive surgery can be both life-saving and result in a good functional outcome. The prognosis is nowadays favorable in most cases, especially compared to arterial stroke, although a significant proportion of patients do suffer from chronic symptoms.
authors.affiliation: Department of Neurology, Academic Medical Center - University of Amsterdam, Room H2-218, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands.
authors.forename: Susanna M
authors.initials: SM
authors.lastname: Zuurbier
authors.affiliation: Department of Neurology, Academic Medical Center - University of Amsterdam, Room H2-218, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands. j.coutinho@amc.nl.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Coutinho
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D002533:Cerebral Angiography / Q000379:methods; D002543:Cerebral Hemorrhage / Q000503:physiopathology; D060825:Cognitive Dysfunction / Q000503:physiopathology; D019299:Decompression, Surgical / Q000379:methods*; D005260:Female; D006261:Headache / Q000503:physiopathology; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D020767:Intracranial Thrombosis / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D010690:Phlebography; D012307:Risk Factors; D012640:Seizures / Q000503:physiopathology; D020246:Venous Thrombosis / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy
chemical_list: D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight
keywords: Anticoagulation; Cerebral venous thrombosis; Dural sinus thrombosis; Endovascular thrombolysis; Intracerebral hemorrhage; Seizures; Stroke