title: Macroreentrant Loop in Ventricular Tachycardia From the Left Posterior Fascicle: New Implications for Mapping and Ablation.
abstract: The underlying mechanisms of reentry during left posterior fascicular ventricular tachycardia (LPF-VT) remain unclear. The purpose of this study is to describe the components of LPF-VT reentry circuit and their electrophysiological properties.
  
  
  
  Fourteen consecutive patients with LPF-VT underwent electrophysiology study and radiofrequency ablation. Via a multipolar electrode catheter placed from a retrograde aortic approach, a sharp inflection, high-frequency potential (P1) was detected in 9 patients (64%). The ranges of length and velocity of recorded P1 were 9 to 30 mm and 0.5 to 1.2 mm/ms, respectively. Macroreentry involving the ventricular myocardium was confirmed to be the mechanism in all patients by premature ventricular stimuli delivery or entrainment of LPF-VT with progressive fusion, or both. During LPF-VT, the earliest left posterior fascicle (LPF, P2) was considered to be the site of connection between P1 and P2, and the site of the earliest P2 along the left posterior ventricular septum correlated well with the His-ventricular interval during tachycardia. Radiofrequency ablation focused on the P1 potentials (9 patients with a recorded P1) or earliest P2 (5 patients without a recorded P1) was successful in all 14 patients. After 4.5±3.0 months of follow-up, no patients had recurrence of LPF-VT.
  
  
  
  The LPF-VT macroreentrant loop involves the ventricular myocardium, a part of the LPF, a slow conduction zone, and in certain cases, a specially conducting P1 fiber. The His-ventricular interval during LPF-VT correlates with multiple electrophysiological measures and is a useful marker for identification of the optimal ablation site.
authors.affiliation: From the Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zhejiang, P.R. China (Q.L., R.J., L.Y., S.C., J.Z., C.J.); and Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA (Q.L., M.S., A.E., A.A.S., E.C., S.S.C., X.W.).
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.affiliation: From the Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zhejiang, P.R. China (Q.L., R.J., L.Y., S.C., J.Z., C.J.); and Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA (Q.L., M.S., A.E., A.A.S., E.C., S.S.C., X.W.).
authors.forename: Michael
authors.initials: M
authors.lastname: Shehata
authors.affiliation: From the Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zhejiang, P.R. China (Q.L., R.J., L.Y., S.C., J.Z., C.J.); and Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA (Q.L., M.S., A.E., A.A.S., E.C., S.S.C., X.W.).
authors.forename: Ruhong
authors.initials: R
authors.lastname: Jiang
authors.affiliation: From the Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zhejiang, P.R. China (Q.L., R.J., L.Y., S.C., J.Z., C.J.); and Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA (Q.L., M.S., A.E., A.A.S., E.C., S.S.C., X.W.).
authors.forename: Lu
authors.initials: L
authors.lastname: Yu
authors.affiliation: From the Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zhejiang, P.R. China (Q.L., R.J., L.Y., S.C., J.Z., C.J.); and Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA (Q.L., M.S., A.E., A.A.S., E.C., S.S.C., X.W.).
authors.forename: Shiquan
authors.initials: S
authors.lastname: Chen
authors.affiliation: From the Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zhejiang, P.R. China (Q.L., R.J., L.Y., S.C., J.Z., C.J.); and Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA (Q.L., M.S., A.E., A.A.S., E.C., S.S.C., X.W.).
authors.forename: Jun
authors.initials: J
authors.lastname: Zhu
authors.affiliation: From the Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zhejiang, P.R. China (Q.L., R.J., L.Y., S.C., J.Z., C.J.); and Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA (Q.L., M.S., A.E., A.A.S., E.C., S.S.C., X.W.).
authors.forename: Ashkan
authors.initials: A
authors.lastname: Ehdaie
authors.affiliation: From the Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zhejiang, P.R. China (Q.L., R.J., L.Y., S.C., J.Z., C.J.); and Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA (Q.L., M.S., A.E., A.A.S., E.C., S.S.C., X.W.).
authors.forename: Ali A
authors.initials: AA
authors.lastname: Sovari
authors.affiliation: From the Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zhejiang, P.R. China (Q.L., R.J., L.Y., S.C., J.Z., C.J.); and Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA (Q.L., M.S., A.E., A.A.S., E.C., S.S.C., X.W.).
authors.forename: Eugenio
authors.initials: E
authors.lastname: Cingolani
authors.affiliation: From the Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zhejiang, P.R. China (Q.L., R.J., L.Y., S.C., J.Z., C.J.); and Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA (Q.L., M.S., A.E., A.A.S., E.C., S.S.C., X.W.).
authors.forename: Sumeet S
authors.initials: SS
authors.lastname: Chugh
authors.affiliation: From the Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zhejiang, P.R. China (Q.L., R.J., L.Y., S.C., J.Z., C.J.); and Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA (Q.L., M.S., A.E., A.A.S., E.C., S.S.C., X.W.). jiangchenyangmail@163.com Xunzhang.Wang@cshs.org.
authors.forename: Chenyang
authors.initials: C
authors.lastname: Jiang
authors.affiliation: From the Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zhejiang, P.R. China (Q.L., R.J., L.Y., S.C., J.Z., C.J.); and Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA (Q.L., M.S., A.E., A.A.S., E.C., S.S.C., X.W.). jiangchenyangmail@163.com Xunzhang.Wang@cshs.org.
authors.forename: Xunzhang
authors.initials: X
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D002036:Bundle of His / Q000503:physiopathology* / Q000601:surgery; D017115:Catheter Ablation / Q000379:methods; D056149:Epicardial Mapping; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017180:Tachycardia, Ventricular / Q000503:physiopathology* / Q000601:surgery; D016896:Treatment Outcome; D054088:Ventricular Septum / Q000503:physiopathology / Q000601:surgery
keywords: bundle of His; catheter ablation; electrophysiology; myocardium; tachycardia