title: Wireless Capsule Enteroscopy in Healthy Volunteers.
abstract: BACKGROUND
  The aim of our prospective study was to define endoscopy appearance of the small bowel in healthy volunteers.
  
  
  METHODS
  Forty-two healthy volunteers underwent wireless capsule endoscopy, clinical investigation, laboratory tests, and completed a health-status questionnaire. All subjects were available for a 36-month clinical follow-up.
  
  
  RESULTS
  Eleven subjects (26%) had fully normal endoscopy findings. Remaining 31 persons (74%), being asymptomatic, with normal laboratory results, had some minor findings at wireless capsule endoscopy. Most of those heterogeneous findings were detected in the small intestine (27/31; 87%), like erosions and/or multiple red spots, diminutive polyps and tiny vascular lesions. During a 36-month clinical follow-up, all these 42 healthy volunteers remained asymptomatic, with fully normal laboratory control.
  
  
  CONCLUSIONS
  Significant part of healthy subjects had abnormal findings at wireless capsule endoscopy. These findings had no clinical relevance, as all these persons remained fully asymptomatic during a 36-month follow-up. Such an endoscopic appearance would be previously evaluated as "pathological". This is a principal report alerting that all findings of any control group of wireless capsule endoscopic studies must be evaluated with caution.
authors.affiliation: Second Department of Internal Medicine - Gastroenterology; Charles University, Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic. tacheci@gmail.com.
authors.forename: Ilja
authors.initials: I
authors.lastname: Tachecí
authors.affiliation: Second Department of Internal Medicine - Gastroenterology; Charles University, Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Bradna
authors.affiliation: Second Department of Internal Medicine - Gastroenterology; Charles University, Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic.
authors.forename: Tomáš
authors.initials: T
authors.lastname: Douda
authors.affiliation: Second Department of Internal Medicine - Gastroenterology; Charles University, Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic.
authors.forename: Drahomíra
authors.initials: D
authors.lastname: Baštecká
authors.affiliation: Second Department of Internal Medicine - Gastroenterology; Charles University, Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic.
authors.forename: Marcela
authors.initials: M
authors.lastname: Kopáčová
authors.affiliation: Second Department of Internal Medicine - Gastroenterology; Charles University, Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic.
authors.forename: Stanislav
authors.initials: S
authors.lastname: Rejchrt
authors.affiliation: Department of Orthopedic Surgery; Charles University Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Lutonský
authors.affiliation: Second Department of Internal Medicine - Gastroenterology; Charles University, Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic.
authors.forename: Tomáš
authors.initials: T
authors.lastname: Soukup
authors.affiliation: Second Department of Internal Medicine - Gastroenterology; Charles University, Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Bureš
mesh_terms: D000328:Adult; D058070:Asymptomatic Diseases; D053704:Capsule Endoscopy; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D033162:Incidental Findings; D007410:Intestinal Diseases / Q000000981:diagnostic imaging*; D007421:Intestine, Small / Q000000981:diagnostic imaging*; D008297:Male; D011446:Prospective Studies; D059015:Wireless Technology
keywords: 36-month follow-up; Healthy volunteers; Small bowel; Wireless capsule enteroscopy