title: A state-of-the-art review and guidelines for tumor treating fields treatment planning and patient follow-up in glioblastoma.
abstract: Tumor treating fields (TTFields) are an integral treatment modality in the management of glioblastoma and extend overall survival when combined with maintenance temozolomide in newly diagnosed patients. Complexities exist regarding correct selection of imaging sequences with which to perform TTFields treatment planning. Guidelines are warranted first, to facilitate treatment planning standardization across medical disciplines and institutions, to ensure optimal TTFields delivery to the tumor and peritumoral brain zone while maximizing patient safety, and also to mitigate the risk of premature cessation of a potentially beneficial treatment. This summary guideline outlines methods for starting patients on TTFields, for monitoring patient response to therapy and provides a framework for evaluating when therapy should be re-planned, based on the extent of sequential imaging changes.
authors.affiliation: Abbott Northwestern Hospital Neuroscience Institute, Minneapolis, MN, USA.
authors.forename: John
authors.initials: J
authors.lastname: Trusheim
authors.affiliation: PiedmontBrain Tumor Center, Atlanta, GA, USA.
authors.forename: Erin
authors.initials: E
authors.lastname: Dunbar
authors.affiliation: Oklahoma University Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: James
authors.initials: J
authors.lastname: Battiste
authors.affiliation: The Neurological Institute of New York, Columbia University, New York, NY, USA.
authors.forename: Fabio
authors.initials: F
authors.lastname: Iwamoto
authors.affiliation: University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: Nimish
authors.initials: N
authors.lastname: Mohile
authors.affiliation: University of Colorado Hospital, Aurora, CO, USA.
authors.forename: Denise
authors.initials: D
authors.lastname: Damek
authors.affiliation: University of California, Irvine Medical Center, Orange, CA, USA.
authors.forename: Daniela A
authors.initials: DA
authors.lastname: Bota
authors.affiliation: Froedtert Hospital & The Medical College of Wisconsin, Milwaukee, WI, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Connelly
mesh_terms: D000465:Algorithms; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*; D003131:Combined Modality Therapy; D003606:Dacarbazine / Q000031:analogs & derivatives / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D005909:Glioblastoma / Q000000981:diagnostic imaging / Q000628:therapy*; D006801:Humans; D055909:Magnetic Field Therapy / Q000379:methods* / Q000592:standards*; D008279:Magnetic Resonance Imaging; D008297:Male; D017410:Practice Guidelines as Topic / Q000592:standards*; D000077204:Temozolomide
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003606:Dacarbazine; D000077204:Temozolomide
keywords: NovoTAL; TTFields; alternating electric fields; glioblastoma; guidelines; response assessment; treatment planning; tumor treating fields