title: [A case of urothelial carcinoma with trophoblastic differentiation and review of the literature].
abstract: We report the case of a 43-year-old woman, who was admitted for intense pelvic pains. Biological investigations showed an increase of β-HCG level. The abdomino-pelvic computed tomography revealed a voluminous mass infiltrating the bladder. A transurethral resection was performed. The histopathological examination evidenced an invasion of the bladder by a massive carcinomatous proliferation composed of clear epithelial cells with in some places syncytiotrophoblastic cells and rarely cytotrophoblastic cells. Immunohistochemical analyses revealed a staining of GATA-3 by the two components, an expression of p63 by the clear cell urothelial component and the immunoreactivity of β-HCG by the trophoblastic component. Ki-67 labeling index was very high. The diagnosis of mixt urothelial carcinoma with clear cells and trophoblastic differentiation was proposed. This is a rare difficult histopathological diagnosis which should be known by pathologists. It is correlated to a poor clinical outcome with a high tendency to lymph node or visceral metastases.
authors.affiliation: Service de neuropathologie, CH Sainte-Anne, 1, rue Cabanis, 75014 Paris, France. Electronic address: arnault.tauziedeespariat@gmail.com.
authors.forename: Arnault
authors.initials: A
authors.lastname: Cazorla
authors.affiliation: Service de pathologie, AP-HP Cochin, 27, rue du faubourg Saint-Jacques, 75679 Paris, France.
authors.forename: Mathilde
authors.initials: M
authors.lastname: Sibony
authors.affiliation: Service d'urologie, hôpital privé du Vert-Galant, 38, rue de Flandre, 93290 Tremblay-en-France, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Pedron
authors.affiliation: Service de neuropathologie, CH Sainte-Anne, 1, rue Cabanis, 75014 Paris, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Munz-Beaugrand
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002295:Carcinoma, Transitional Cell / Q000737:chemistry / Q000473:pathology*; D002454:Cell Differentiation; D002822:Choriocarcinoma / Q000175:diagnosis; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D050990:GATA3 Transcription Factor / Q000032:analysis; D006801:Humans; D008565:Membrane Proteins / Q000032:analysis; D009363:Neoplasm Proteins / Q000032:analysis; D014327:Trophoblasts / Q000737:chemistry / Q000473:pathology*; D001749:Urinary Bladder Neoplasms / Q000737:chemistry / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; C081876:CKAP4 protein, human; D018997:Chorionic Gonadotropin, beta Subunit, Human; D050990:GATA3 Transcription Factor; C494749:GATA3 protein, human; D008565:Membrane Proteins; D009363:Neoplasm Proteins
keywords: Bladder; Carcinome urothélial; Différenciation trophoblastique; Trophoblastic differentiation; Urothelial carcinoma; Vessie