title: Anaplastic Transformation in Mandibular Metastases of Follicular Variant of Papillary Thyroid Carcinoma: A Case Report and Review of the Literature.
abstract: Anaplastic transformation of well-differentiated thyroid carcinomas at distant metastatic sites is a rare condition. Most cases described in the literature have occurred in the thyroid or regional lymph nodes. We report a case of anaplastic transformation of the follicular variant of papillary thyroid carcinoma in mandibular metastases. A 76-year-old female presented with a painful and enlarging mandibular mass. She had been treated in the past for the follicular variant of papillary thyroid carcinoma. A palliative hemi-mandibulectomy was performed. Histology revealed a metastatic papillary thyroid carcinoma, follicular variant, with an unusual finding of solid pleomorphic epithelioid and spindle cell areas, consistent with anaplastic transformation.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston-McGovern Medical School, Houston, TX, USA Manju.Ambelil@uth.tmc.edu.
authors.forename: Manju
authors.initials: M
authors.lastname: Ambelil
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston-McGovern Medical School, Houston, TX, USA.
authors.forename: Sadia
authors.initials: S
authors.lastname: Sultana
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston-McGovern Medical School, Houston, TX, USA.
authors.forename: Suvra
authors.initials: S
authors.lastname: Roy
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston-McGovern Medical School, Houston, TX, USA.
authors.forename: Maria M
authors.initials: MM
authors.lastname: Gonzalez
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000473:pathology*; D002291:Carcinoma, Papillary; D018265:Carcinoma, Papillary, Follicular / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008339:Mandibular Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary*; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D000077273:Thyroid Cancer, Papillary; D065646:Thyroid Carcinoma, Anaplastic / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000473:pathology*; D014057:Tomography, X-Ray Computed
keywords: Anaplastic transformation; mandibular metastasis; papillary thyroid carcinoma