title: Magnetic resonance diffusion tensor imaging following major ozonated autohemotherapy for treatment of acute cerebral infarction.
abstract: Major ozonated autohemotherapy has been shown to promote recovery of upper limb motor function in patients with acute cerebral infarction, but whether major ozonated autohemotherapy affects remote injury remains poorly understood. Here, we assumed that major ozonated autohemotherapy contributes to recovery of clinical function, possibly by reducing remote injury after acute cerebral infarction. Sixty acute cerebral infarction patients aged 30-80 years were equally and randomly allocated to ozone treatment and control groups. Patients in the ozone treatment group received medical treatment and major ozonated autohemotherapy (47 mg/L, 100 mL ozone) for 10 ± 2 days. Patients in the control group received medical treatment only. National Institutes of Health Stroke Scale score, modified Rankin scale score, and reduced degree of fractional anisotropy values of brain magnetic resonance diffusion tensor imaging were remarkably decreased, brain function improved, clinical efficiency significantly increased, and no obvious adverse reactions detected in the ozone treatment group compared with the control group. These findings suggest that major ozonated autohemotherapy promotes recovery of neurological function in acute cerebral infarction patients by reducing remote injury, and additionally, exhibits high safety.
authors.affiliation: Department of Neurology, Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China; Department of Neurology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong Province, China.
authors.forename: Xiao-Na
authors.initials: XN
authors.lastname: Wu
authors.affiliation: Department of Orthopedics, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong Province, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of MRI, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Neurology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong Province, China.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Liu
authors.affiliation: Department of Neurology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong Province, China.
authors.forename: Zhen-Sheng
authors.initials: ZS
authors.lastname: Li
authors.affiliation: Department of Neurology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xiang
authors.affiliation: Department of MRI, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong Province, China.
authors.forename: Wei-Qing
authors.initials: WQ
authors.lastname: Du
authors.affiliation: Department of Neurology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong Province, China.
authors.forename: Hong-Jun
authors.initials: HJ
authors.lastname: Yang
authors.affiliation: Department of Neurology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong Province, China.
authors.forename: Tie-Gen
authors.initials: TG
authors.lastname: Xiong
authors.affiliation: Department of Neurology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong Province, China.
authors.forename: Wen-Ting
authors.initials: WT
authors.lastname: Deng
authors.affiliation: Department of Neurology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong Province, China.
authors.forename: Kai-Run
authors.identifier: 0000-0003-4784-2451
authors.initials: KR
authors.lastname: Peng
authors.affiliation: Department of Neurology, Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China.
authors.forename: Su-Yue
authors.identifier: 0000-0003-2744-1984
authors.initials: SY
authors.lastname: Pan
keywords: anisotropy; cerebral infarction; cerebral peduncle; corticospinal tract; diffusion tensor imaging; internal capsule; magnetic resonance; nerve regeneration; neural regeneration; ozone; white matter