title: [Involvement of mucous membranes in autoimmune bullous diseases].
abstract: Autoimmune bullous diseases are characterized by intraepidermal or subepidermal autoantibody deposition that leads to blisters and secondary erosion. Mucous membranes are frequently affected in pemphigus vulgaris and always involved in cicatricial and mucosal pemphigoid. Mucosal lesions are detected less frequently in patients with bullous pemphigoid or epidermolysis bullosa acquisita. The diagnosis of autoimmune bullous disorders is based on determination of the subtype of autoantibodies bound in the skin and the clinical picture. Treatment is based on immunosuppression related to the type of disease and severity of the mucosal symptoms. Ocular involvement in mucosal pemphigoid and pemphigus vulgaris requires systemic treatment.
authors.affiliation: Klinik und Poliklinik für Dermatologie, Universitätsklinikum Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland. claudia.guenther@uniklinikum-dresden.de.
authors.forename: C
authors.initials: C
authors.lastname: Günther
mesh_terms: D003937:Diagnosis, Differential; D019317:Evidence-Based Medicine; D005128:Eye Diseases / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D009059:Mouth Diseases / Q000175:diagnosis / Q000188:drug therapy; D009092:Mucous Membrane / Q000473:pathology*; D010390:Pemphigoid, Benign Mucous Membrane / Q000175:diagnosis* / Q000188:drug therapy*; D010392:Pemphigus / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents
keywords: Autoantibodies; Immunosuppression; Mucosal pemphigoid; Pemphigus vulgaris; Systemic therapy