title: Diffusion and perfusion weighted magnetic resonance imaging for tumor volume definition in radiotherapy of brain tumors.
abstract: Accurate target volume delineation is crucial for the radiotherapy of tumors. Diffusion and perfusion magnetic resonance imaging (MRI) can provide functional information about brain tumors, and they are able to detect tumor volume and physiological changes beyond the lesions shown on conventional MRI. This review examines recent studies that utilized diffusion and perfusion MRI for tumor volume definition in radiotherapy of brain tumors, and it presents the opportunities and challenges in the integration of multimodal functional MRI into clinical practice. The results indicate that specialized and robust post-processing algorithms and tools are needed for the precise alignment of targets on the images, and comprehensive validations with more clinical data are important for the improvement of the correlation between histopathologic results and MRI parameter images.
authors.affiliation: Department of Biomedical Engineering, Tianjin University, Tianjin, 300072, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Guo
authors.affiliation: Department of Biomedical Engineering, Tianjin University, Tianjin, 300072, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Biomedical Engineering, Tianjin University, Tianjin, 300072, China. fengyu@ecu.edu.|Department of Radiation Oncology, Tianjin Medical University Cancer Institute & Hospital, Tianjin, 300060, China. fengyu@ecu.edu.|Department of Radiation Oncology, East Carolina University, 600 Moye Blvd, Greenville, NC, 27834, USA. fengyu@ecu.edu.
authors.forename: Yuanming
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Department of Radiology, Huashan hospital, Fudan University, Shanghai, 200040, China.
authors.forename: Tonggang
authors.initials: T
authors.lastname: Yu
authors.affiliation: Department of Biomedical Engineering, Tianjin University, Tianjin, 300072, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Department of Radiology, Tianjin Medical University Cancer Institute & Hospital, Tianjin, 300060, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Bai
authors.affiliation: Department of Radiology, Tianjin Medical University Cancer Institute & Hospital, Tianjin, 300060, China.
authors.forename: Zhaoxiang
authors.initials: Z
authors.lastname: Ye
keywords: Brain tumors; Diffusion; Perfusion; Radiotherapy; Tumor volume definition