title: Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies.
abstract: Cellular therapies with tolerogenic antigen-presenting cells (tolAPC) show great promise for the treatment of autoimmune diseases and for the prevention of destructive immune responses after transplantation. The methodologies for generating tolAPC vary greatly between different laboratories, making it difficult to compare data from different studies; thus constituting a major hurdle for the development of standardised tolAPC therapeutic products. Here we describe an initiative by members of the tolAPC field to generate a minimum information model for tolAPC (MITAP), providing a reporting framework that will make differences and similarities between tolAPC products transparent. In this way, MITAP constitutes a first but important step towards the production of standardised and reproducible tolAPC for clinical application.
authors.affiliation: School of Computing Science, Newcastle University, Newcastle upon Tyne, United Kingdom.
authors.forename: Phillip
authors.initials: P
authors.lastname: Lord
authors.affiliation: Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
authors.forename: Rachel
authors.initials: R
authors.lastname: Spiering
authors.affiliation: Instituto de Ciencias Biomédicas (ICBM), Universidad de Chile, Santiago, Chile.
authors.forename: Juan C
authors.initials: JC
authors.lastname: Aguillon
authors.affiliation: Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
authors.forename: Amy E
authors.initials: AE
authors.lastname: Anderson
authors.affiliation: Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.
authors.forename: Silke
authors.initials: S
authors.lastname: Appel
authors.affiliation: Department of Immunology, Hospital Clínic i Provincial and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Benitez-Ribas
authors.affiliation: Department of Immunopathology, Sanquin Research, Amsterdam, The Netherlands.
authors.forename: Anja
authors.initials: A
authors.lastname: Ten Brinke
authors.affiliation: Faculty of Veterinary Medicine, Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands.
authors.forename: Femke
authors.initials: F
authors.lastname: Broere
authors.affiliation: Laboratory of Experimental Hematology, Vaccine & Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Cools
authors.affiliation: Center for Research in Transplantation and Immunology, ITUN, Inserm UMRS 1064, Nantes, France.
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Cuturi
authors.affiliation: Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
authors.forename: Julie
authors.initials: J
authors.lastname: Diboll
authors.affiliation: Department of Surgery, Section of Experimental Surgery, University Hospital Regensburg, Regensburg, Germany.
authors.forename: Edward K
authors.initials: EK
authors.lastname: Geissler
authors.affiliation: Institute of Cellular Therapeutics, Allegheny Health Network, Pittsburgh, PA, United States of America.
authors.forename: Nick
authors.initials: N
authors.lastname: Giannoukakis
authors.affiliation: San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Division of Regenerative Medicine, Stem Cells and Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Gregori
authors.affiliation: Department of Immunopathology, Sanquin Research, Amsterdam, The Netherlands.
authors.forename: S Marieke
authors.initials: SM
authors.lastname: van Ham
authors.affiliation: School of Computing Science, Newcastle University, Newcastle upon Tyne, United Kingdom.
authors.forename: Staci
authors.initials: S
authors.lastname: Lattimer
authors.affiliation: School of Computing Science, Newcastle University, Newcastle upon Tyne, United Kingdom.
authors.forename: Lindsay
authors.initials: L
authors.lastname: Marshall
authors.affiliation: Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
authors.forename: Rachel A
authors.initials: RA
authors.lastname: Harry
authors.affiliation: Department of Surgery, Section of Experimental Surgery, University Hospital Regensburg, Regensburg, Germany.
authors.forename: James A
authors.initials: JA
authors.lastname: Hutchinson
authors.affiliation: Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
authors.forename: John D
authors.initials: JD
authors.lastname: Isaacs
authors.affiliation: Department of Laboratory Medicine, Radboud University medical center, Nijmegen, The Netherlands.
authors.forename: Irma
authors.initials: I
authors.lastname: Joosten
authors.affiliation: Department of Nephrology, Leiden University Medical Centre, Leiden, The Netherlands.
authors.forename: Cees
authors.initials: C
authors.lastname: van Kooten
authors.affiliation: Area of Cell Therapy, University Clinic of Navarra, Pamplona, Spain.
authors.forename: Ascension
authors.initials: A
authors.lastname: Lopez Diaz de Cerio
authors.affiliation: Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Nikolic
authors.affiliation: Department of Immunology, Faculty of Medicine, Uludag University, Bursa, Turkey.
authors.forename: Haluk Barbaros
authors.initials: HB
authors.lastname: Oral
authors.affiliation: Institute for the Application of Nuclear Energy INEP, University of Belgrade, Belgrade, Serbia.
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Sofronic-Milosavljevic
authors.affiliation: Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine, Nursing and Health Sciences, National University of Ireland, Galway, Ireland.
authors.forename: Thomas
authors.initials: T
authors.lastname: Ritter
authors.affiliation: Department of Surgery, Section of Experimental Surgery, University Hospital Regensburg, Regensburg, Germany.
authors.forename: Paloma
authors.initials: P
authors.lastname: Riquelme
authors.affiliation: Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America.
authors.forename: Angus W
authors.initials: AW
authors.lastname: Thomson
authors.affiliation: Institute of Cellular Therapeutics, Allegheny Health Network, Pittsburgh, PA, United States of America.
authors.forename: Massimo
authors.initials: M
authors.lastname: Trucco
authors.affiliation: Immunology Division, Germans Trias i Pujol University Hospital and Health Sciences Research Institute, Badalona, Spain.|CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Vives-Pi
authors.affiliation: Immunology Division, Germans Trias i Pujol University Hospital and Health Sciences Research Institute, Badalona, Spain.|Department of Cell Biology, Physiology, Immunology, Universitat Autònoma, Barcelona.
authors.forename: Eva M
authors.initials: EM
authors.lastname: Martinez-Caceres
authors.affiliation: Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
authors.forename: Catharien M U
authors.initials: CMU
authors.lastname: Hilkens
keywords: Antigen-presenting cells; Autoimmune disease; Cell therapy; Minimum information model; Regulatory macrophages; Reporting guidelines; Tolerogenic dendritic cells; Transplantation