title: Novel blood-brain barrier-permeable spin probe for in vivo electron paramagnetic resonance imaging.
abstract: A novel blood-brain barrier (BBB)-permeable compound 10 was discovered, wherein the nitroxide moiety was linked to a nicotine acetylcholine receptor ligand. It was applied as a probe for electron paramagnetic resonance (EPR) imaging of the mouse brain. The results demonstrated that the newly synthesized compound 10 exhibited BBB permeability. These findings provide an essential discovery for in vivo EPR imaging.
authors.affiliation: Department of Biomolecular Sciences, Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan.
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Arts and Sciences, Center for Medical Education, Sapporo Medical University, South 1, West 17, Chuo-ku, Sapporo 060-8556, Japan.
authors.forename: Miho
authors.initials: M
authors.lastname: Emoto
authors.affiliation: Division of Bioengineering and Bioinformatics, Graduate School of Information Science and Technology, Hokkaido University, North 14, West 9, Kita-ku, Sapporo 060-0814, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Miyake
authors.affiliation: Department of Biomolecular Sciences, Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Itto
authors.affiliation: Department of Biomolecular Sciences, Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan.
authors.forename: Shu
authors.initials: S
authors.lastname: Xu
authors.affiliation: Department of Arts and Sciences, Center for Medical Education, Sapporo Medical University, South 1, West 17, Chuo-ku, Sapporo 060-8556, Japan.
authors.forename: Hirotada
authors.initials: H
authors.lastname: Fujii
authors.affiliation: Division of Bioengineering and Bioinformatics, Graduate School of Information Science and Technology, Hokkaido University, North 14, West 9, Kita-ku, Sapporo 060-0814, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hirata
authors.affiliation: Department of Biomolecular Sciences, Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan. Electronic address: arimoto@biochem.tohoku.ac.jp.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Arimoto
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods*; D051379:Mice; D013113:Spin Labels
chemical_list: D013113:Spin Labels
keywords: Blood–brain barrier permeable; EPR brain imaging; Nitroxide; Spin probe