title: Association between COMT Val158Met polymorphism and preeclampsia in the Chinese Han population.
abstract: OBJECTIVE
  Previous studies have been indicated that catechol-O-methyltransferase gene (COMT) might play a significant role in the development of preeclampsia (PE). Our study aims to investigate the association between polymorphism in COMT with the susceptibility to PE in Chinese Han women.
  
  
  METHODS
  A total of 1028 PE patients and 1399 normal pregnant women were enrolled. We detected the genotyping of COMT Val158Met loci by the TaqMan allelic discrimination real-time PCR .
  
  
  RESULTS
  No significant difference in the genotypic and allelic distribution was found between the two groups (genotype: X2= 0.583, p = 0.747; allele:X2= 0.526, p = 0.468).
  
  
  CONCLUSIONS
  The COMT Val158Met polymorphism might not be associated with PE in Chinese women.
authors.affiliation: a Clinical Laboratory , Linyi People's Hospital , Linyi , China.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Zhao
authors.affiliation: b Department of Blood Transfusion , The Affiliated Hospital of Qingdao University , Qingdao , China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Liu
authors.affiliation: c Clinical Laboratory Center , Gansu Provincial Maternity and Child-care Hospital , Gansu , China.
authors.forename: Cuisheng
authors.initials: C
authors.lastname: Zhao
authors.affiliation: c Clinical Laboratory Center , Gansu Provincial Maternity and Child-care Hospital , Gansu , China.
authors.forename: Ping
authors.initials: P
authors.lastname: Ye
authors.affiliation: d Department of Pathogenic Microorganisms , The Medical College of Qingdao University , Qingdao , China.
authors.forename: Jing
authors.initials: J
authors.lastname: Ji
authors.affiliation: e Prenatal Diagnosis Center , The Affiliated Hospital of Qingdao University , Qingdao , China.
authors.forename: Jingli
authors.initials: J
authors.lastname: Wang
authors.affiliation: f Department of Clinical Laboratory , Qingdao Municipal Hospital (Group) , Qingdao , China.
authors.forename: Weiqing
authors.initials: W
authors.lastname: Song
authors.affiliation: g Obstetrical Department , The Affiliated Hospital of Qingdao University , Qingdao , China.
authors.forename: Jine
authors.initials: J
authors.lastname: Xu
authors.affiliation: e Prenatal Diagnosis Center , The Affiliated Hospital of Qingdao University , Qingdao , China.
authors.forename: Shiguo
authors.initials: S
authors.lastname: Liu
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy
chemical_list: C588010:COMT protein, human; D002394:Catechol O-Methyltransferase
keywords: COMT; polymorphism; preeclampsia; val158Met(rs4680)