title: Depression, daily stressors and inflammatory responses to high-fat meals: when stress overrides healthier food choices.
abstract: Depression, stress and diet can all alter inflammation. This double-blind, randomized crossover study addressed the impact of daily stressors and a history of major depressive disorder (MDD) on inflammatory responses to high-fat meals. During two separate 9.5 h admissions, 58 healthy women (38 breast cancer survivors and 20 demographically similar controls), mean age 53.1 years, received either a high saturated fat meal or a high oleic sunflower oil meal. The Daily Inventory of Stressful Events assessed prior day stressors and the Structured Clinical Interview for DSM-IV evaluated MDD. As expected, for a woman with no prior day stressors, C-reactive protein (CRP), serum amyloid A (SAA), intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) were higher following the saturated fat meal than the high oleic sunflower oil meal after controlling for pre-meal measures, age, trunk fat and physical activity. But if a woman had prior day stressors, these meal-related differences disappeared-because the stressors heightened CRP, SAA, sICAM-1 and sVCAM-1 responses to the sunflower oil meal, making it look more like the responses to the saturated fat meal. In addition, women with an MDD history had higher post-meal blood pressure responses than those without a similar history. These data show how recent stressors and an MDD history can reverberate through metabolic alterations, promoting inflammatory and atherogenic responses.
authors.affiliation: Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, Columbus, OH, USA.|Department of Psychiatry and Behavioral Health, The Ohio State University College of Medicine, Columbus, OH, USA.
authors.forename: J K
authors.initials: JK
authors.lastname: Kiecolt-Glaser
authors.affiliation: Department of Psychology, Rice University, Houston, TX, USA.|Department of Symptoms Research, MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: C P
authors.initials: CP
authors.lastname: Fagundes
authors.affiliation: Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, OH, USA.
authors.forename: R
authors.initials: R
authors.lastname: Andridge
authors.affiliation: Center for Biostatistics, The Ohio State University, Columbus, OH, USA.
authors.forename: J
authors.initials: J
authors.lastname: Peng
authors.affiliation: Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, Columbus, OH, USA.|Department of Medicine, The Ohio State University Medical Center, Columbus, OH, USA.
authors.forename: W B
authors.initials: WB
authors.lastname: Malarkey
authors.affiliation: Health and Rehabilitation Sciences, The Ohio State University Medical Center, Columbus, OH, USA.
authors.forename: D
authors.initials: D
authors.lastname: Habash
authors.affiliation: Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, Columbus, OH, USA.|Department of Human Sciences, College of Education and Human Ecology, The Ohio State University, Columbus, OH, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Belury
mesh_terms: D002097:C-Reactive Protein; D018592:Cross-Over Studies; D003863:Depression / Q000178:diet therapy / Q000378:metabolism*; D003865:Major Depressive Disorder / Q000378:metabolism; D004032:Diet; D059305:Diet, High-Fat / Q000009:adverse effects* / Q000523:psychology; D004041:Dietary Fats; D004311:Double-Blind Method; D005260:Female; D005518:Food Preferences / Q000523:psychology; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000178:diet therapy; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008875:Middle Aged; D019518:Postprandial Period / Q000502:physiology; D000685:Serum Amyloid A Protein; D013315:Stress, Psychological / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
chemical_list: D004041:Dietary Fats; D000685:Serum Amyloid A Protein; D014280:Triglycerides; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1; D002097:C-Reactive Protein