title: Three-dimensional Contrast-enhanced Ultrasound in Response Assessment for Breast Cancer: A Comparison with Dynamic Contrast-enhanced Magnetic Resonance Imaging and Pathology.
abstract: To compare the capabilities of three-dimensional contrast enhanced ultrasound (3D-CEUS) and dynamic contrast-enhanced magnetic resonance (DCE-MRI) in predicting the response to neoadjuvant chemotherapy (NAC) among breast cancer patients, 48 patients with unilateral breast cancer were recruited for 3D-CEUS and DCE-MRI examinations both before and after NAC; pathology was used to validate the results. This study was approved by the institutional review board, and written informed consent was obtained from each patient. Imaging feature changes and pathological vascularity response, including microvessel density (MVD) and vascular endothelial growth factor (VEGF), were calculated. Pathological complete response (pCR) and major histological response (MHR) were used as references. The 3D-CEUS score, DCE-MRI score, MVD and VEGF significantly decreased (P < 0.0001) after NAC. The correlations between Δ3D-CEUS and ΔDCE-MRI with pCR (r = 0.649, P < 0.0001; r = 0.639, P < 0.0001) and MHR (r = 0.863, P < 0.0001; r = 0.836, P < 0.0001) were significant. All scores showed significant differences between the pCR and non-pCR groups with folder changes of 0.1, 0.1, 2.4, and 2.3, respectively (P = 0.0001, <0.0001, <0.0001 and <0.0001). In conclusion, 3D-CEUS is effective in assessing the response of breast cancer patients undergoing NAC.
authors.affiliation: Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Department of Diagnostic Ultrasound, Shanghai, 200025, China.
authors.forename: Wan-Ru
authors.initials: WR
authors.lastname: Jia
authors.affiliation: Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Department of Diagnostic Ultrasound, Shanghai, 200025, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Tang
authors.affiliation: Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Department of Radiology, Shanghai, 200092, China.
authors.forename: Deng-Bin
authors.initials: DB
authors.lastname: Wang
authors.affiliation: Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Department of Radiology, Shanghai, 200025, China.
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Chai
authors.affiliation: Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Department of Pathology, Shanghai, 200025, China.
authors.forename: Xiao-Chun
authors.initials: XC
authors.lastname: Fei
authors.affiliation: Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Department of Comprehensive breast health center, Shanghai, 200025, China.
authors.forename: Jian-Rong
authors.initials: JR
authors.lastname: He
authors.affiliation: Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Department of Diagnostic Ultrasound, Shanghai, 200025, China.
authors.forename: Man
authors.initials: M
authors.lastname: Chen
authors.affiliation: Zhong Shan Hospital, Fu Dan University School of Medicine, Shanghai, 200025, China.
authors.forename: Wen-Ping
authors.initials: WP
authors.lastname: Wang