title: Mechanism and Function of Angiogenin in Apoptosis Regulation.
abstract: Angiogenin (ANG), a secreted ribonuclease, has been characterized recently as an anti-apoptosis factor involved in a variety of cellular anti-apoptosis process. ANG regulates intrinsic pathways-related major molecules such as anti-apoptotic protein Bcl-2, as well as extrinsic signaling pathways. Moreover, ANG regulates p53-regulated apoptosis, a process considered to be important in regulating both the extrinsic and the intrinsic pathways.
authors.affiliation: Molecular Oncology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA.
authors.forename: L I
authors.initials: LI
authors.lastname: Shu-Ping
authors.affiliation: Molecular Oncology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA.
authors.forename: H U
authors.initials: HU
authors.lastname: Guo-Fu
keywords: Bcl-2; angiogenin; apoptosis; p 53