title: Feasibility of carotid artery PET/MRI in psoriasis patients.
abstract: We report our initial experience of performing integrated PET/MR imaging of the carotid arteries in psoriatic patients. Eleven patients with psoriasis and ten controls underwent carotid PET/MRI. Following injection of the FDG tracer, 3d T1w gradient echo sequence (atMR) was obtained for attenuation correction of PET data. High resolution images of carotid artery were then obtained, including pre-and post-contrast T1-w, T2-w and proton-density images as well as TOF images followed by PET imaging of the torso. From the fused axial PET/MRI, the arterial wall SUVmax and TBRmax was quantified in each slice. MRI images were also evaluated for vessel wall volume, plaque and internal composition. SUVmax and TBRmax were respectively, 1.72 ± 0.38 & 1.17 ± 0.27 in L- CCA, 1.75 ± 0.39 & 1.24 ± 0.19 in R-CCA, 1.59 ± 0.24 & 1.08 ± 0.14 in L-ICA and 1.62 ± 0.27 & 1.15 ± 0.17 in R-ICA in psoriatic patients and 1.74 ± 0.22 & 1.28 ± 0.44 in L- CCA, 1.74 ± 0.33 & 1.07 ± 0.28 in R-CCA, 1.78 ± 0.32 & 1.29 ± 0.39 in L-ICA and 1.60 ± 0.29 & 0.98 ± 0.25 in R-ICA in the controls. No discrete plaques were identified in any of the vessel segments in MRI. PET/MRI is feasible in evaluation of carotid arteries in psoriatic patients.
authors.affiliation: Department of Radiology, University Hospital Cleveland Case Medical Center, Case Western Reserve University School of MedicineCleveland, Ohio, United States; Department of Radiology, Cardiothoracic Imaging, UT Southwestern Medical CenterDallas, Texas, United States.
authors.forename: Prabhakar
authors.initials: P
authors.lastname: Rajiah
authors.affiliation: Department of Radiology, University Hospital Cleveland Case Medical Center, Case Western Reserve University School of Medicine Cleveland, Ohio, United States.
authors.forename: Mojgan
authors.initials: M
authors.lastname: Hojjati
authors.affiliation: Department of Radiology, University Hospital Cleveland Case Medical Center, Case Western Reserve University School of Medicine Cleveland, Ohio, United States.
authors.forename: Ziang
authors.initials: Z
authors.lastname: Lu
authors.affiliation: Department of Radiology, University Hospital Cleveland Case Medical Center, Case Western Reserve University School of Medicine Cleveland, Ohio, United States.
authors.forename: Vijaya
authors.initials: V
authors.lastname: Kosaraju
authors.affiliation: Department of Radiology, University Hospital Cleveland Case Medical Center, Case Western Reserve University School of Medicine Cleveland, Ohio, United States.
authors.forename: Sasan
authors.initials: S
authors.lastname: Partovi
authors.affiliation: Department of Radiology, University Hospital Cleveland Case Medical Center, Case Western Reserve University School of Medicine Cleveland, Ohio, United States.
authors.forename: James K
authors.initials: JK
authors.lastname: O'Donnell
authors.affiliation: Department of Cardiology, University Hospital Cleveland Case Medical Center, Case Western Reserve University School of Medicine Cleveland, Ohio, United States.
authors.forename: Christopher
authors.initials: C
authors.lastname: Longenecker
authors.affiliation: Department of Pediatrics and Medicine, University Hospital Cleveland Case Medical Center, Case Western Reserve University School of Medicine Cleveland, Ohio, United States.
authors.forename: Grace A
authors.initials: GA
authors.lastname: McComsey
authors.affiliation: Department of Dermatology, University Hospital Cleveland Case Medical Center, Case Western Reserve University School of Medicine Cleveland, Ohio, United States.
authors.forename: Jackelyn B
authors.initials: JB
authors.lastname: Golden
authors.affiliation: Department of Dermatology, University Hospital Cleveland Case Medical Center, Case Western Reserve University School of Medicine Cleveland, Ohio, United States.
authors.forename: Fuad
authors.initials: F
authors.lastname: Muakkassa
authors.affiliation: Department of Dermatology, University Hospital Cleveland Case Medical Center, Case Western Reserve University School of Medicine Cleveland, Ohio, United States.
authors.forename: Scott
authors.initials: S
authors.lastname: Santilli
authors.affiliation: Department of Dermatology, University Hospital Cleveland Case Medical Center, Case Western Reserve University School of Medicine Cleveland, Ohio, United States.
authors.forename: Thomas S
authors.initials: TS
authors.lastname: McCormick
authors.affiliation: Department of Dermatology, University Hospital Cleveland Case Medical Center, Case Western Reserve University School of Medicine Cleveland, Ohio, United States.
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Cooper
authors.affiliation: Department of Dermatology, University Hospital Cleveland Case Medical Center, Case Western Reserve University School of Medicine Cleveland, Ohio, United States.
authors.forename: Neil J
authors.initials: NJ
authors.lastname: Korman
keywords: MRI; PET; Psoriasis; atherosclerosis; carotid; inflammation