title: Telomerase Regulation from Beginning to the End.
abstract: The vast body of literature regarding human telomere maintenance is a true testament to the importance of understanding telomere regulation in both normal and diseased states. In this review, our goal was simple: tell the telomerase story from the biogenesis of its parts to its maturity as a complex and function at its site of action, emphasizing new developments and how they contribute to the foundational knowledge of telomerase and telomere biology.
authors.affiliation: Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Côte Ste-Catherine Road, Montréal, QC H3T 1E2, Canada. deanna.macneil@mail.mcgill.ca.|Room M-29, Department of Anatomy and Cell Biology, McGill University, 3640 University Street, Montréal, QC H3A 0C7, Canada. deanna.macneil@mail.mcgill.ca.
authors.forename: Deanna Elise
authors.initials: DE
authors.lastname: MacNeil
authors.affiliation: Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Côte Ste-Catherine Road, Montréal, QC H3T 1E2, Canada. helene.bensoussan@mail.mcgill.ca.|Room M-29, Department of Anatomy and Cell Biology, McGill University, 3640 University Street, Montréal, QC H3A 0C7, Canada. helene.bensoussan@mail.mcgill.ca.
authors.forename: Hélène Jeanne
authors.initials: HJ
authors.lastname: Bensoussan
authors.affiliation: Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Côte Ste-Catherine Road, Montréal, QC H3T 1E2, Canada. chantal.autexier@mcgill.ca.|Room M-29, Department of Anatomy and Cell Biology, McGill University, 3640 University Street, Montréal, QC H3A 0C7, Canada. chantal.autexier@mcgill.ca.|Department of Experimental Medicine, McGill University, 1110 Pins Avenue West, Room 101, Montréal, QC H3A 1A3, Canada. chantal.autexier@mcgill.ca.
authors.forename: Chantal
authors.initials: C
authors.lastname: Autexier
keywords: H/ACA ribonucleoprotein; exosome; small Cajal body RNA; small nucleolar RNA; spliceosome; telomerase; telomere