title: Repeated courses of intratympanic dexamethasone injection are effective for intractable Meniere's disease.
abstract: CONCLUSIONS
  Intra-tympanic dexamethasone injection (ITD) could serve as a first-line intra-tympanic (IT) treatment for Meniere's disease (MD), regardless of hearing level. Even if the response to initial ITD course was unsatisfactory, a repeated course may be beneficial with some patients.
  
  
  OBJECTIVE
  This study examined the effect of repeated courses of ITD administered on demand and investigated the possibility of ITD as an initial IT treatment for medically intractable MD patients.
  
  
  METHODS
  Fifty-one patients who had been diagnosed with definite MD and given course(s) of ITD treatment were included. Vertigo control, pure tone average and functional disability scores were evaluated against the American Academy of Otolaryngology-Head and Neck Surgery guidelines for MD.
  
  
  RESULTS
  Vertigo disappeared or was substantially controlled in 58.8% and 23.5% of the patients, respectively, after the first ITD course. A repeated course further raised the complete vertigo control rate by 15.7% and intra-tympanic gentamycin injection could be postponed or avoided in 78.6% of the patients who required repeated IT treatment. Hearing was unchanged after the first course of ITD (p > .05). No significant differences were detected in the clinical profiles or laboratory findings between patients receiving single course of ITD and those on multiple courses (p > .05).
authors.affiliation: a Department of Otolaryngology , Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei Province , PR China.
authors.forename: Yangming
authors.initials: Y
authors.lastname: Leng
authors.affiliation: a Department of Otolaryngology , Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei Province , PR China.
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.affiliation: a Department of Otolaryngology , Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei Province , PR China.
authors.forename: Renhong
authors.initials: R
authors.lastname: Zhou
authors.affiliation: a Department of Otolaryngology , Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei Province , PR China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Liu
authors.affiliation: a Department of Otolaryngology , Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei Province , PR China.
authors.forename: Dongdong
authors.initials: D
authors.lastname: Liu
authors.affiliation: a Department of Otolaryngology , Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei Province , PR China.
authors.forename: Su-Lin
authors.initials: SL
authors.lastname: Zhang
authors.affiliation: a Department of Otolaryngology , Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei Province , PR China.
authors.forename: Wei-Jia
authors.initials: WJ
authors.lastname: Kong
mesh_terms: D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D003907:Dexamethasone / Q000008:administration & dosage*; D005260:Female; D006309:Hearing / Q000187:drug effects*; D006801:Humans; D000069555:Injection, Intratympanic / Q000706:statistics & numerical data*; D053208:Kaplan-Meier Estimate; D008297:Male; D008575:Meniere Disease / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D012189:Retrospective Studies; D014717:Vertigo / Q000188:drug therapy* / Q000209:etiology; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D003907:Dexamethasone
keywords: Meniere’s disease; dexamethasone; injection; intra-tympanic