title: Influence of hemodialysis on regadenoson clearance in an in vitro hemodialysis model.
abstract: Regadenoson is a novel pharmacological stress agent whose disposition during hemodialysis is not known. The purpose of this study was to determine the clearance of regadenoson under varying dialytic conditions using an in vitro hemodialysis model.
  
  
  
  Whole human blood was used to analyze the effect of hemodialysis on the clearance of regadenoson. Regadenoson transmembrane clearance (CLD) was assessed for both a standard permeability and a high permeability polysulfone hemodialyzer with blood/dialysate flow rates of 300/600 and 400/800 mL/min. A two-tailed, paired Student's t test was used to compare regadenoson CLDbetween hemodialyzer types and flow rates. The mean ± SD regadenoson CLDvalues ranged between 62.5 ± 11.8 and 89.1 ± 24.0 mL/min for all dialytic conditions. There was no significant difference in regadenoson CLDbetween hemodialyzer types and flow rates (p > .05).
  
  
  
  Hemodialysis enhances the clearance of regadenoson independent of hemodialyzer permeability and blood/dialysate flow rate. This clearance is modest relative to total body clearance and is unlikely to produce a clinically significant outcome.
authors.affiliation: School of Pharmacy, Medical College of Wisconsin, Milwaukee, WI, USA.
authors.forename: Katherine N
authors.initials: KN
authors.lastname: Gharibian
authors.affiliation: Departments of Internal Medicine and Radiology, Medical School, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Venkatesh L
authors.initials: VL
authors.lastname: Murthy
authors.affiliation: Department of Clinical Pharmacy, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, MI, 48109, USA. muellerb@med.umich.edu.
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Mueller
mesh_terms: D058908:Adenosine A2 Receptor Agonists / Q000493:pharmacokinetics*; D003404:Creatinine / Q000097:blood; D006801:Humans; D066298:In Vitro Techniques; D010539:Permeability; D011108:Polymers; D011379:Prognosis; D011687:Purines / Q000493:pharmacokinetics*; D011720:Pyrazoles / Q000493:pharmacokinetics*; D006435:Renal Dialysis / Q000009:adverse effects*; D013450:Sulfones; D014508:Urea / Q000097:blood
chemical_list: D058908:Adenosine A2 Receptor Agonists; D011108:Polymers; D011687:Purines; D011720:Pyrazoles; D013450:Sulfones; C017662:polysulfone P 1700; C430916:regadenoson; D014508:Urea; D003404:Creatinine
keywords: Regadenoson; chronic kidney disease (CKD); clearance; hemodialysis