title: Association of Parkinson's disease with hospitalization for traumatic brain injury.
abstract: OBJECTIVE
  The goal of our study was to determine if patients with Parkinson's disease (PD) are more susceptible to hospitalization for traumatic brain injury (TBI).
  
  
  METHODS
  The US Nationwide Inpatient Sample database was queried (2004-2011) to identify cohorts of patients with PD (N = 1 047 656) and without PD (N = 115 95 173). The age range of the study population was 60-89 years. The incidence of TBI among patients with PD was compared to the incidence of TBI in patients without PD. A multivariate logistic regression model, adjusted for all covariates that significantly differed in the bivariate analyses, was used to determine if PD was an independent predictor of TBI hospitalization.
  
  
  RESULTS
  The incidence of TBI hospitalization was significantly higher (relative risk: 1.76, 95% CI: 1.73-1.80) in the PD cohort. The PD cohort with TBI had fewer comorbidities and risk factors for falls/TBI compared to the non-PD cohort with TBI. The multivariable analysis, adjusting for other TBI risk factors, revealed that PD status increased the likelihood of TBI hospitalization (odds ratio: 2.99, 95% CI: 2.93-3.05).
  
  
  CONCLUSIONS
  Our study shows that patients with PD are more susceptible to hospitalization for TBI. A greater proportion of fall-related TBI occurs in patients with PD compared to patients without PD. Further research is needed to prevent falls in PD patients to avoid TBI.
authors.affiliation: a University of Missouri-Kansas City School of Medicine , Kansas City , MO , USA.
authors.forename: Kavelin
authors.initials: K
authors.lastname: Rumalla
authors.affiliation: a University of Missouri-Kansas City School of Medicine , Kansas City , MO , USA.
authors.forename: Keerthi T
authors.initials: KT
authors.lastname: Gondi
authors.affiliation: a University of Missouri-Kansas City School of Medicine , Kansas City , MO , USA.
authors.forename: Adithi Y
authors.initials: AY
authors.lastname: Reddy
authors.affiliation: b Department of Neurology , University of Kansas Medical Center , Kansas City , KS , USA.
authors.forename: Manoj K
authors.initials: MK
authors.lastname: Mittal
mesh_terms: D000058:Accidental Falls / Q000706:statistics & numerical data; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000070642:Brain Injuries, Traumatic / Q000453:epidemiology* / Q000209:etiology / Q000628:therapy*; D015331:Cohort Studies; D016208:Databases, Factual / Q000706:statistics & numerical data; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology*; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
keywords: Nationwide Inpatient Sample; Parkinson's disease; falls; risk factors; traumatic brain injury