title: Spices: Potential Therapeutics for Alzheimer's Disease.
abstract: India has traditionally been known to all over the world for spices and medicinal plants. Spices exhibit a wide range of pharmacological activities. In contemporary, Indian spices are used to rustle up delicious delicacies. However, the Indian spices are more than just adjuvant which adds aroma and fragrance to foods. A few spices are very widely used and grown commercially in many countries, contain many important chemical constituents in the form of essential oil, oleoresin, oleogum, and resins, which impart flavor, pungency, and color to the prepared dishes, simultaneously exerts diverse therapeutic benefits. Ayurveda, the traditional systems of medicine in India has many evidences for the utilization of spices to cure various diseases. Some of the activities have been scientifically proven. Among various indications central nervous system disorders are of prime importance and it has been evident in traditional books and published reports that spices in fact protect and cure neuronal ailments. Likewise there are many spices found in India used for culinary purpose and have been found to have reported specific activities against brain disorders. About 400 B.C., Hippocrates rightly said "Let food be thy medicine and medicine thy food." This review focuses on the importance of spices in therapeutics and the till date scientific findings of Indian spices in CNS pharmacology and explores the potential of Indian spices to cure CNS disorders.
authors.affiliation: Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research, Hyderabad (NIPER-H), Balanagar, Hyderabad, 500037, Telangana, India. satish.niperhyd@gov.in.
authors.forename: N
authors.initials: N
authors.lastname: Satheeshkumar
authors.affiliation: Department of Chemistry, Temple University, Philadelphia, PA, 19122-1801, USA.
authors.forename: R S K
authors.initials: RS
authors.lastname: Vijayan
authors.affiliation: Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research, Hyderabad (NIPER-H), Balanagar, Hyderabad, 500037, Telangana, India.
authors.forename: A
authors.initials: A
authors.lastname: Lingesh
authors.affiliation: Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research, Hyderabad (NIPER-H), Balanagar, Hyderabad, 500037, Telangana, India.
authors.forename: S
authors.initials: S
authors.lastname: Santhikumar
authors.affiliation: Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research, Hyderabad (NIPER-H), Balanagar, Hyderabad, 500037, Telangana, India.
authors.forename: Ch
authors.initials: Ch
authors.lastname: Vishnuvardhan
mesh_terms: D000544:Alzheimer Disease / Q000628:therapy*; D006801:Humans; D007194:India; D008515:Medicine, Ayurvedic / Q000592:standards; D010946:Plants, Medicinal / Q000737:chemistry; D017365:Spices
keywords: Alzheimer’s disease; Ayurveda; Indian spices; Neurodegenerative disorders; Toxicity