title: Targeted Raman Imaging of Cells Using Graphene Oxide-Based Hybrids.
abstract: Graphene oxide (GO) is a reliable and multifunctional platform to perform cell imaging. In this work, a controllable Pt-seed-mediated method is used to prepare GO/gold nanoparticle (AuNP) hybrids, and after the covalent binding of folic acid (FA), GO/AuNP/FA hybrids are prepared. Selective labeling and Raman imaging of folate receptor (FR)-positive HeLa cells are realized using such GO-based hybrids. In this system, FA is the targeting agent, AuNPs work as surface-enhanced Raman scattering substrates, and GO takes the role of both supporting the AuNPs with FA and acting as a Raman probe. This research further extends the application of GO as a multifunctional platform in bioimaging and other biomedical processes.
authors.affiliation: Beijing National Laboratory for Molecular Science, Key Laboratory for the Physics and Chemistry of Nanodevices, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University , Beijing 100871, China.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Beijing National Laboratory for Molecular Science, Key Laboratory for the Physics and Chemistry of Nanodevices, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University , Beijing 100871, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.affiliation: Beijing National Laboratory for Molecular Science, Key Laboratory for the Physics and Chemistry of Nanodevices, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University , Beijing 100871, China.
authors.forename: Dongliang
authors.initials: D
authors.lastname: Gao
authors.affiliation: Beijing National Laboratory for Molecular Science, Key Laboratory for the Physics and Chemistry of Nanodevices, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University , Beijing 100871, China.
authors.forename: Da
authors.initials: D
authors.lastname: Luo
authors.affiliation: Beijing National Laboratory for Molecular Science, Key Laboratory for the Physics and Chemistry of Nanodevices, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University , Beijing 100871, China.
authors.forename: Qinghai
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Beijing National Laboratory for Molecular Science, Key Laboratory for the Physics and Chemistry of Nanodevices, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University , Beijing 100871, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Yang
authors.affiliation: Beijing National Laboratory for Molecular Science, Key Laboratory for the Physics and Chemistry of Nanodevices, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University , Beijing 100871, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
mesh_terms: D045744:Cell Line, Tumor; D058973:Folate Receptors, GPI-Anchored / Q000378:metabolism; D005492:Folic Acid / Q000737:chemistry / Q000378:metabolism; D006046:Gold / Q000737:chemistry; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000000981:diagnostic imaging*; D010087:Oxides / Q000737:chemistry*; D013059:Spectrum Analysis, Raman / Q000379:methods; D013864:Thioglycolates / Q000737:chemistry
chemical_list: D058973:Folate Receptors, GPI-Anchored; D010087:Oxides; D013864:Thioglycolates; D006046:Gold; D006108:Graphite; C017487:2-mercaptoacetate; D005492:Folic Acid