title: Susceptibility of Candida albicans Isolated from Blood to Wickerhamomyces anomalous Mycocins.
abstract: The occurrence of infections caused by Candida albicans in developed and developing countries and their resistance to some available antifungal drugs have been viewed as causing a great problem to human health worldwide. In order to find new researched molecules, there are some mycoses secreted by yeasts, especially mycocins produced by Wickerhamomyces anomalus with a broad antimicrobial spectrum of activity. Thus, this trial aimed at evaluating mycocins' activity obtained from environmental W. anomalus cell wall compared to thirty C. albicans strains isolated from blood. Mycocins were extracted from cell walls of three W. anomalus strains (WA40, WA45, and WA92). The 400 μg mL-1concentration of WA40M1, WA45M2, and WA92M3 mycocin extracts showed the following respective activity results: 96.6, 96.6, and 90.0 % C. albicans strains. WA45M2 and WA92M3 mycocin extracts showed some activity in 3.3 % of C. albicans strains at 50 μg mL-1concentration. Mycocins extracted from cell walls of three W. anomalus strains named as WA40, WA45, and WA92 showed antifungal activity compared to C. albicans and low degree of hemolysis.
authors.affiliation: Hospital Universitário do Oeste do Paraná,Universidade Estadual do Oeste do Paraná-UNIOESTE, Av. Tancredo Neves, 3224, Cascavel, PR, 85806-470, Brazil. anapaula.paris@hotmail.com.
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Paris
authors.affiliation: Hospital Universitário do Oeste do Paraná,Universidade Estadual do Oeste do Paraná-UNIOESTE, Av. Tancredo Neves, 3224, Cascavel, PR, 85806-470, Brazil.
authors.forename: Cristiane
authors.initials: C
authors.lastname: Persel
authors.affiliation: Hospital Universitário do Oeste do Paraná,Universidade Estadual do Oeste do Paraná-UNIOESTE, Av. Tancredo Neves, 3224, Cascavel, PR, 85806-470, Brazil.
authors.forename: Cleber Fernando
authors.initials: CF
authors.lastname: Serafin
authors.affiliation: Laboratório de Bioquímica Molecular, Centro de Ciências Médicas e Farmacêuticas, Universidade Estadual do Oeste do Paraná, UNIOESTE, Cascavel, PR, Brazil.
authors.forename: Rita
authors.initials: R
authors.lastname: de Cássia Garcia Simão
authors.affiliation: Hospital Universitário do Oeste do Paraná,Universidade Estadual do Oeste do Paraná-UNIOESTE, Av. Tancredo Neves, 3224, Cascavel, PR, 85806-470, Brazil.
authors.forename: Rinaldo Ferreira
authors.initials: RF
authors.lastname: Gandra
mesh_terms: D000935:Antifungal Agents / Q000378:metabolism / Q000494:pharmacology*; D001769:Blood / Q000382:microbiology*; D002176:Candida albicans / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D002177:Candidiasis / Q000097:blood / Q000382:microbiology*; D002473:Cell Wall / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008826:Microbial Sensitivity Tests; D004718:Saccharomycetales / Q000737:chemistry* / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism; D012988:Soil Microbiology
chemical_list: D000935:Antifungal Agents