title: Bacterial-Fungal Interactions Including Quorum Sensing, Between 2 Opportunistic Pathogens, Resulting in Post-Traumatic Sepsis in a Child Presenting With a Closed Femoral Fracture.
abstract: Pseudomonas aeruginosa and Candida albicans (are opportunistic pathogens that cause systemic infections in immune-suppressed patients. They show important bacterial-fungal interactions including quorum sensing. This involves cell signaling to communicate between the cells of their own colony and the cells of rival microbes or the host. It is thought that this phenomenon is vital in the potential competition and virulence of the organisms. We report a case of a previously healthy 2-year-old boy, where an accidental injury had been sustained resulting in a closed fracture of femur. He subsequently developed sepsis related to co-infection by C. albicans and P. aeruginosa. Trauma may result in a transient immune-suppression and predispose to sepsis caused by opportunistic microorganisms. They can engage in bacterial-fungal interaction. Clinicians should consider invasive co-infection when initial cultures show evidence for only 1 pathogen.
authors.affiliation: From the Department of Paediatrics, Medway Maritime Hospital, Gillingham, Kent, United Kingdom.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Bradford
authors.forename: Kate
authors.initials: K
authors.lastname: O'Loughlin
authors.forename: Alice
authors.initials: A
authors.lastname: Munro
authors.forename: Bhavdeep R
authors.initials: BR
authors.lastname: Jani
authors.forename: Surendra
authors.initials: S
authors.lastname: Singham
authors.forename: Janette
authors.initials: J
authors.lastname: Cansick
mesh_terms: D002176:Candida albicans; D058387:Candidemia; D002675:Child, Preschool; D060085:Coinfection / Q000382:microbiology*; D005264:Femoral Fractures / Q000150:complications*; D006801:Humans; D008297:Male; D056265:Microbial Interactions; D009894:Opportunistic Infections; D011552:Pseudomonas Infections; D011550:Pseudomonas aeruginosa; D053038:Quorum Sensing; D018805:Sepsis / Q000382:microbiology*