title: BRCA1-CtIP interaction in the repair of DNA double-strand breaks.
abstract: DNA termini at double-strand breaks are often chemically heterogeneous and require processing before initiation of repair. In a recent report, we demonstrated that CtIP and the MRE11-RAD50-NBS1 (MRN) nuclease complex cooperate with BRCA1 to specifically repair topoisomerase II-DNA adducted breaks. In contrast, BRCA1 is dispensable for repair of restriction endonuclease-generated double-strand breaks.
authors.affiliation: The Institute for Cancer Genetics, Columbia University , New York, NY, USA.
authors.forename: Tomas
authors.initials: T
authors.lastname: Aparicio
authors.affiliation: The Institute for Cancer Genetics, Columbia University , New York, NY, USA.
authors.forename: Jean
authors.initials: J
authors.lastname: Gautier
keywords: DNA damage and repair; DNA double-strand breaks; DNA end resection; homologous recombination; topoisomerases