title: The Emerging Role of B Cells in Tumor Immunity.
abstract: There is increasing evidence supporting a role for B cells in tumor immunology. Paraneoplastic syndromes occurring before a cancer diagnosis have pointed to the potential for harnessing the humoral immune response for early cancer detection. The presence of tumor-infiltrating B lymphocytes has been linked to a favorable clinical outcome in many types of cancers. However, B cells represent a heterogeneous population with functionally distinct subsets, and the balance among subtypes impacts tumor development. Here, we review recent findings related to B cells and to the humoral immune response in cancer and their translational significance. Cancer Res; 76(19); 5597-601. ©2016 AACR.
authors.affiliation: The University of Texas M.D. Anderson Cancer Center, Houston, Texas.
authors.forename: Peiling
authors.initials: P
authors.lastname: Tsou
authors.affiliation: The University of Texas M.D. Anderson Cancer Center, Houston, Texas.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Katayama
authors.affiliation: The University of Texas M.D. Anderson Cancer Center, Houston, Texas.
authors.forename: Edwin J
authors.initials: EJ
authors.lastname: Ostrin
authors.affiliation: The University of Texas M.D. Anderson Cancer Center, Houston, Texas. shanash@mdanderson.org.
authors.forename: Samir M
authors.initials: SM
authors.lastname: Hanash
mesh_terms: D001323:Autoantibodies / Q000032:analysis / Q000627:therapeutic use; D015551:Autoimmunity; D001402:B-Lymphocytes / Q000276:immunology*; D015415:Biomarkers; D006801:Humans; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology; D009369:Neoplasms / Q000276:immunology*; D059016:Tumor Microenvironment
chemical_list: D001323:Autoantibodies; D015415:Biomarkers