title: Plasma and serum concentrations of cytarabine administered via continuous intravenous infusion to dogs with meningoencephalomyelitis of unknown etiology.
abstract: The objective of this study was to evaluate the plasma and serum concentrations of cytarabine (CA) administered via constant rate infusion (CRI) in dogs with meningoencephalomyelitis of unknown etiology (MUE). Nineteen client-owned dogs received a CRI of CA at a dose of 25 mg/m2/h for 8 h as treatment for MUE. Dogs were divided into four groups, those receiving CA alone and those receiving CA in conjunction with other drugs. Blood samples were collected at 0, 1, 8, and 12 h after initiating the CRI. Plasma (n = 13) and serum (n = 11) cytarabine concentrations were measured by high-pressure liquid chromatography. The mean peak concentration (CMAX) and area under the curve (AUC) after CRI administration were 1.70 ± 0.66 μg/mL and 11.39 ± 3.37 h·μg/mL, respectively, for dogs receiving cytarabine alone, 2.36 ± 0.35 μg/mL and 16.91 + 3.60 h·μg/mL for dogs administered cytarabine and concurrently on other drugs. Mean concentrations for all dogs were above 1.0 μg/mL at both the 1- and 8-h time points. The steady-state achieved with cytarabine CRI produces a consistent and prolonged exposure in plasma and serum, which is likely to produce equilibrium between blood and the central nervous system in dogs with a clinical diagnosis of MUE. Other medications commonly used to treat MUE do not appear to alter CA concentrations in serum and plasma.
authors.affiliation: College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
authors.forename: P J
authors.initials: PJ
authors.lastname: Early
authors.affiliation: Charleston Veterinary Referral Center, Charleston, SC, USA.
authors.forename: K I
authors.initials: KI
authors.lastname: Crook
authors.affiliation: Carolina Veterinary Specialist, Winston Salem, NC, USA.
authors.forename: L M
authors.initials: LM
authors.lastname: Williams
authors.affiliation: Sugar Land Veterinary Specialists, Sugar Land, TX, USA.
authors.forename: E G
authors.initials: EG
authors.lastname: Davis
authors.affiliation: College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
authors.forename: K R
authors.initials: KR
authors.lastname: Muñana
authors.affiliation: College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
authors.forename: M G
authors.initials: MG
authors.lastname: Papich
authors.affiliation: College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
authors.forename: K M
authors.identifier: http://orcid.org/0000-0001-8161-4482
authors.initials: KM
authors.lastname: Messenger
mesh_terms: D000818:Animals; D019540:Area Under Curve; D003561:Cytarabine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004283:Dog Diseases / Q000097:blood / Q000188:drug therapy*; D004285:Dogs; D004679:Encephalomyelitis / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*; D007262:Infusions, Intravenous / Q000662:veterinary*
chemical_list: D003561:Cytarabine