title: Restraining the Divider: A Drp1-Phospholipid Interaction Inhibits Drp1 Activity and Shifts the Balance from Mitochondrial Fission to Fusion.
abstract: In this issue of Molecular Cell, Adachi et al. (2016) describe a novel interaction between the mitochondrial fission GTPase Drp1 and phosphatidic acid that restrains Drp1 activity and shifts the balance toward mitochondrial fusion, adding another layer of complexity to the regulation of mitochondrial dynamics.
authors.affiliation: Department of Microbiology, Immunology, and Cancer Biology, University of Virginia Health System, Charlottesville, VA 22908, USA. Electronic address: kashatus@virginia.edu.
authors.forename: David F
authors.initials: DF
authors.lastname: Kashatus
mesh_terms: D020558:GTP Phosphohydrolases; D008928:Mitochondria; D063154:Mitochondrial Dynamics; D024101:Mitochondrial Proteins; D010743:Phospholipids
chemical_list: D024101:Mitochondrial Proteins; D010743:Phospholipids; D020558:GTP Phosphohydrolases