title: Data on the transcriptional regulation of DNA damage induced apoptosis suppressor (DDIAS) by ERK5/MEF2B pathway in lung cancer cells.
abstract: The data included in this article are associated with the article entitled "DNA-damage-induced apoptosis suppressor (DDIAS) is upregulated via ERK5/MEF2B signaling and promotes β-catenin-mediated invasion" (J.Y. Im, S.H. Yoon, B.K. Kim, H.S. Ban, K.J. Won, K.S. Chung, K.E. Jung, M. Won) [1]. Quantitative RT-PCR data revealed that genetic or pharmacological inhibition of extracellular signal-regulated kinase 5 (ERK5) suppresses DDIAS transcription in response to epidermal growth factor (EGF) in Hela cells. p300 did not interact with myocyte enhancer factor 2B (MEF2B), a downstream target of ERK5 and affect transcription of DDIAS. Moreover, DDIAS transcription is activated by ERK5/MEF2B signaling on EGF exposure in the non-small cell lung cancer cells (NSCLC) NCI-H1703 and NCI-H1299. DDIAS knockdown suppresses lung cancer cell invasion by decreasing β-catenin protein level on EGF exposure.
authors.affiliation: Personalized Genomic Medicine Research Center, KRIBB, Daejeon 305-806, Korea.
authors.forename: Joo-Young
authors.initials: JY
authors.lastname: Im
authors.affiliation: Personalized Genomic Medicine Research Center, KRIBB, Daejeon 305-806, Korea; Functional Genomics, University of Science and Technology, Daejeon 305-701, Korea.
authors.forename: Sung-Hoon
authors.initials: SH
authors.lastname: Yoon
authors.affiliation: Personalized Genomic Medicine Research Center, KRIBB, Daejeon 305-806, Korea.
authors.forename: Bo-Kyung
authors.initials: BK
authors.lastname: Kim
authors.affiliation: Biomedical Translational Research Center, KRIBB, Daejeon 305-806, Korea.
authors.forename: Hyun Seung
authors.initials: HS
authors.lastname: Ban
authors.affiliation: Personalized Genomic Medicine Research Center, KRIBB, Daejeon 305-806, Korea; Functional Genomics, University of Science and Technology, Daejeon 305-701, Korea.
authors.forename: Kyoung-Jae
authors.initials: KJ
authors.lastname: Won
authors.affiliation: Biomedical Translational Research Center, KRIBB, Daejeon 305-806, Korea.
authors.forename: Kyung-Sook
authors.initials: KS
authors.lastname: Chung
authors.affiliation: ST Pharm. Co., LTD, Sihwa Industrial Complex 1, Kyunggido 429-848, Korea.
authors.forename: Kyeong Eun
authors.initials: KE
authors.lastname: Jung
authors.affiliation: Personalized Genomic Medicine Research Center, KRIBB, Daejeon 305-806, Korea; Functional Genomics, University of Science and Technology, Daejeon 305-701, Korea.
authors.forename: Misun
authors.initials: M
authors.lastname: Won
keywords: DDIAS; ERK5; Lung cancer; MEF2B