title: Angiotensin II receptor blocker combined with eplerenone or hydrochlorothiazide for hypertensive patients with diabetes mellitus.
abstract: Experimental models recently suggested an interaction between aldosterone and adipose tissue, but clinical investigation has been limited. We studied the effects of eplerenone compared to hydrochlorothiazide (HCTZ) on blood pressure (BP), glucose, and lipid levels in 50 patients with essential hypertension (EHT) and type 2 diabetes mellitus whose BP failed to reach target levels with 8 mg of candesartan alone. BP improved similarly in both groups over the 12-month study period, but BMI, waist circumference, and LDL-cholesterol were decreased in the eplerenone group, while glycohemoglobin was elevated in the HCTZ group.
authors.affiliation: a Department of Internal Medicine , Graduate School of Medical Science, Kanazawa University , Kanazawa , Japan.
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Karashima
authors.affiliation: a Department of Internal Medicine , Graduate School of Medical Science, Kanazawa University , Kanazawa , Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoneda
authors.affiliation: a Department of Internal Medicine , Graduate School of Medical Science, Kanazawa University , Kanazawa , Japan.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Kometani
authors.affiliation: a Department of Internal Medicine , Graduate School of Medical Science, Kanazawa University , Kanazawa , Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Ohe
authors.affiliation: a Department of Internal Medicine , Graduate School of Medical Science, Kanazawa University , Kanazawa , Japan.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Mori
authors.affiliation: a Department of Internal Medicine , Graduate School of Medical Science, Kanazawa University , Kanazawa , Japan.
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Sawamura
authors.affiliation: b Department of Internal Medicine , Kanazawa Insurance Hospital , Kanazawa , Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Furukawa
authors.affiliation: c Department of Cardiovascular Disease , Graduate School of Medical Science, Kanazawa University , Kanazawa , Japan.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Yamagishi
authors.affiliation: a Department of Internal Medicine , Graduate School of Medical Science, Kanazawa University , Kanazawa , Japan.
authors.forename: Yoshiyu
authors.initials: Y
authors.lastname: Takeda
mesh_terms: D000328:Adult; D000368:Aged; D057911:Angiotensin Receptor Antagonists / Q000008:administration & dosage; D000959:Antihypertensive Agents / Q000008:administration & dosage; D001562:Benzimidazoles / Q000008:administration & dosage / Q000009:adverse effects; D001713:Biphenyl Compounds; D001794:Blood Pressure / Q000187:drug effects*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D016903:Drug Monitoring / Q000379:methods; D004359:Drug Therapy, Combination / Q000379:methods; D000077545:Eplerenone; D000075222:Essential Hypertension; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage / Q000009:adverse effects; D006973:Hypertension / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D000451:Mineralocorticoid Receptor Antagonists / Q000008:administration & dosage; D013148:Spironolactone / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D013777:Tetrazoles / Q000008:administration & dosage / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D057911:Angiotensin Receptor Antagonists; D000959:Antihypertensive Agents; D001562:Benzimidazoles; D001713:Biphenyl Compounds; D000077545:Eplerenone; D006442:Glycated Hemoglobin; D006852:Hydrochlorothiazide; D000451:Mineralocorticoid Receptor Antagonists; D013148:Spironolactone; D013777:Tetrazoles; C081643:candesartan
keywords: Aldosterone; adiponectin; combination therapy; diabetes; eplerenone