title: Stem Cell Mobilizers: Novel Therapeutics for Acute Kidney Injury.
abstract: In the past decade, rapid developments in stem cell studies have occurred. Researchers have confirmed the plasticity of bone marrow stem cells and the repair and regeneration effects of bone marrow hematopoietic stem cells on solid organs. These findings have suggested the possibility of using bone marrow stem cell mobilizers to repair and regenerate injured organs. Recent studies on the effects of granulocyte colony-stimulating factor (G-CSF) and Plerixafor (AMD3100) on mouse acute kidney injury models have confirmed that the use of bone marrow stem cell mobilizers may be an effective therapeutic measure. This paper summarizes studies describing the effects of G-CSF and AMD3100 on various acute kidney injury models over the past 10 years.
authors.affiliation: Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing. China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing. China.
authors.forename: Song
authors.initials: S
authors.lastname: Zeng
authors.affiliation: Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing. China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing. China.
authors.forename: Zijian
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, NO.8 GongTi South Road, Beijing. China.
authors.forename: Xiaopeng
authors.initials: X
authors.lastname: Hu
mesh_terms: D058186:Acute Kidney Injury / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D000818:Animals; D001596:Benzylamines; D054377:Chemokine CXCL12 / Q000235:genetics / Q000276:immunology; D000080027:Cyclams; D004195:Disease Models, Animal; D005786:Gene Expression Regulation / Q000187:drug effects*; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D006571:Heterocyclic Compounds / Q000494:pharmacology*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D020780:Matrix Metalloproteinase 9 / Q000235:genetics / Q000276:immunology; D051379:Mice; D019718:Receptors, CXCR4 / Q000235:genetics / Q000276:immunology; D015398:Signal Transduction
chemical_list: D001596:Benzylamines; C514936:CXCR4 protein, mouse; D054377:Chemokine CXCL12; C515256:Cxcl12 protein, mouse; D000080027:Cyclams; D006571:Heterocyclic Compounds; D019718:Receptors, CXCR4; D016179:Granulocyte Colony-Stimulating Factor; D020780:Matrix Metalloproteinase 9; C501830:Mmp9 protein, mouse; C088327:plerixafor
keywords: Acute kidney injuries; bone marrow stem cells; granulocyte colony-stimulating factor; plerixafor