title: Impact of a Pharmacy-Cardiology Collaborative Practice on Dofetilide Safety Monitoring.
abstract: BACKGROUND
  Limited studies have been published examining dofetilide's postmarketing use and its recommended monitoring.
  
  
  OBJECTIVE
  To evaluate the impact of a collaborative pharmacy-cardiology antiarrhythmic drug (AAD) monitoring program on dofetilide monitoring.
  
  
  METHODS
  This retrospective cohort study was performed to assess if a novel monitoring program improved compliance with dofetilide-specific monitoring parameters based on the Food and Drug Administration's Risk Evaluation and Mitigation Strategy.
  
  
  RESULTS
  A total of 30 patients were included in the analysis. The monitoring parameters evaluated included electrocardiogram, serum potassium, serum magnesium, and kidney function. The primary outcome evaluated was the composite of these dofetilide monitoring parameters obtained in each cohort. In the standard cohort, 245 of 352 (69.6%) monitoring parameters were completed versus 134 of 136 (98.5%) in the intervention group ( P < 0.05).
  
  
  CONCLUSIONS
  A collaborative pharmacy-cardiology AAD monitoring program was associated with a significant improvement in dofetilide monitoring. This improvement could potentially translate into enhanced patient safety outcomes, such as prevention of adverse drug reactions and decreased hospitalizations.
authors.affiliation: 1 North Florida/South Georgia Veterans Health System, Gainesville, FL, USA.
authors.forename: Lieth H
authors.initials: LH
authors.lastname: Quffa
authors.affiliation: 1 North Florida/South Georgia Veterans Health System, Gainesville, FL, USA.|2 University of Florida, Gainesville, FL, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Panna
authors.affiliation: 1 North Florida/South Georgia Veterans Health System, Gainesville, FL, USA.|2 University of Florida, Gainesville, FL, USA.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Kaufmann
authors.affiliation: 1 North Florida/South Georgia Veterans Health System, Gainesville, FL, USA.|2 University of Florida, Gainesville, FL, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: McKillop
authors.affiliation: 1 North Florida/South Georgia Veterans Health System, Gainesville, FL, USA.
authors.forename: Nicole Maltese
authors.initials: NM
authors.lastname: Dietrich
authors.affiliation: 1 North Florida/South Georgia Veterans Health System, Gainesville, FL, USA.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Franck
mesh_terms: D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000072096:Cardiologists / Q000458:organization & administration* / Q000592:standards; D004347:Drug Interactions; D016903:Drug Monitoring / Q000379:methods*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000175:diagnosis / Q000517:prevention & control*; D004562:Electrocardiography; D005260:Female; D006760:Hospitalization; D006801:Humans; D000070516:Intersectoral Collaboration; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D010595:Pharmacists / Q000458:organization & administration* / Q000592:standards; D010627:Phenethylamines / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D012189:Retrospective Studies; D013449:Sulfonamides / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000889:Anti-Arrhythmia Agents; D010627:Phenethylamines; D013449:Sulfonamides; C063533:dofetilide
keywords: antiarrhythmics; cardiology; drug monitoring and drug safety; pharmaceutical care