title: Asymmetric division: An antitumor player?
abstract: miR-34a-mediated asymmetric cell division reins in excessive stem cell expansion during tissue regeneration in the intestine and colon. Loss of miR-34a switches asymmetric division to symmetric division and enhances stem cell proliferation. Asymmetric division also occurs in the early stages of colon cancer stem cells. Mechanistically, miR-34a, Numb, and Notch form a feed-forward loop that specifies cell fate when stem cells divide.
authors.affiliation: Department of Biological and Environmental Engineering, Cornell University , Ithaca, NY, USA.
authors.forename: Lihua
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA; Departments of Biomedical Engineering, Duke University, Durham, NC, USA.
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Bu
authors.affiliation: Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY, USA; Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA; Departments of Biomedical Engineering, Duke University, Durham, NC, USA.
authors.forename: Xiling
authors.initials: X
authors.lastname: Shen