title: Diving into the abyss of undiscovered kidney function-related factors.
abstract: Meta-analyses and reintroduction of biological knowledge are 2 classic strategies to increase genomewide association study statistical power and overcome the burden of multiple testing. These strategies have empowered the nephrology community to discover new signals associated with kidney function and nephropathies. Here we discuss the current genomewide association study limitations and strategies to dive further into the abyss of yet-to-be discovered kidney function-related factors.
authors.affiliation: Molecular Genetic Epidemiology Section, Basic Research Laboratory, Basic Science Program, Leidos Biomedical Research, Inc., National Cancer Institute, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
authors.forename: Sophie
authors.initials: S
authors.lastname: Limou
authors.affiliation: Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland, USA; Department of Medicine, Baltimore VA Medical Center, Baltimore, Maryland, USA. Electronic address: aparsa@medicine.umaryland.edu.
authors.forename: Afshin
authors.initials: A
authors.lastname: Parsa
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004242:Diving; D055106:Genome-Wide Association Study; D006801:Humans; D007668:Kidney; D051379:Mice; D013997:Time Factors