title: A Lack of Clinical Effect of High-frequency rTMS to Dorsolateral Prefrontal Cortex on Bulimic Symptoms: A Randomised, Double-blind Trial.
abstract: Studies suggest that stimulation of the left dorsolateral prefrontal cortex (DLPFC) reduces food craving in bulimic patients, but evidence supporting repetitive transcranial magnetic stimulation (rTMS) as a therapeutic tool is lacking. We investigated the safety and therapeutic efficacy of an adjunct high-frequency rTMS programme targeting the left DLPFC. Forty-seven women with bulimia nervosa were randomised to a real or sham stimulation group. The real group underwent 10 rTMS sessions, each consisting of 20 trains of 5 seconds with 55-second intervals between trains, at a frequency of 10 Hz. The main outcome was the number of binge episodes in the 15 days following the end of stimulation. Overall, no significant improvement in bingeing and purging symptoms was noted after the programme. rTMS was well tolerated. This suggests that 10 sessions of high-frequency rTMS to the left DLPFC provide no greater benefit than placebo. Future studies should consider methodological issues as well as alternative targets. Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association.
authors.affiliation: University Department of Psychiatry and Addictology, North Hospital, CHU St-Etienne, St Etienne, France.|TAPE Laboratory, EA7423, Jean Monnet University, Saint Etienne, France.
authors.forename: Aurelia
authors.initials: A
authors.lastname: Gay
authors.affiliation: Inserm U1061, University of Montpellier, Montpellier, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Jaussent
authors.affiliation: University Department of Psychiatry and Addictology, North Hospital, CHU St-Etienne, St Etienne, France.|TAPE Laboratory, EA7423, Jean Monnet University, Saint Etienne, France.
authors.forename: Torrance
authors.initials: T
authors.lastname: Sigaud
authors.affiliation: University Department of Psychiatry and Addictology, North Hospital, CHU St-Etienne, St Etienne, France.
authors.forename: Stephane
authors.initials: S
authors.lastname: Billard
authors.affiliation: Inserm U1061, University of Montpellier, Montpellier, France.|University Department of Adult Psychiatry, CHRU Montpellier, Montpellier, France.
authors.forename: Jerome
authors.initials: J
authors.lastname: Attal
authors.affiliation: Inserm U1061, University of Montpellier, Montpellier, France.|Department of Psychiatric Emergency & Acute Care, Lapeyronie Hospital, CHRU Montpellier, Montpellier, France.
authors.forename: Maude
authors.initials: M
authors.lastname: Seneque
authors.affiliation: TAPE Laboratory, EA7423, Jean Monnet University, Saint Etienne, France.
authors.forename: Bogdan
authors.initials: B
authors.lastname: Galusca
authors.affiliation: Eating Disorders Program, Department of Psychiatry, Douglas Hospital, McGill University, Montreal, Canada.
authors.forename: Frederique
authors.initials: F
authors.lastname: Van Den Eynde
authors.affiliation: University Department of Psychiatry and Addictology, North Hospital, CHU St-Etienne, St Etienne, France.|TAPE Laboratory, EA7423, Jean Monnet University, Saint Etienne, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Massoubre
authors.affiliation: Inserm U1061, University of Montpellier, Montpellier, France.|Department of Psychiatric Emergency & Acute Care, Lapeyronie Hospital, CHRU Montpellier, Montpellier, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Courtet
authors.affiliation: Inserm U1061, University of Montpellier, Montpellier, France. s-guillaume@chu-montpellier.fr.|Department of Psychiatric Emergency & Acute Care, Lapeyronie Hospital, CHRU Montpellier, Montpellier, France. s-guillaume@chu-montpellier.fr.
authors.forename: Sebastien
authors.identifier: 0000-0002-6769-9982
authors.initials: S
authors.lastname: Guillaume
mesh_terms: D000328:Adult; D016739:Behavior, Addictive / Q000628:therapy; D056912:Binge-Eating Disorder / Q000523:psychology*; D002032:Bulimia / Q000175:diagnosis / Q000523:psychology / Q000628:therapy*; D052018:Bulimia Nervosa / Q000523:psychology* / Q000628:therapy; D066249:Craving; D004311:Double-Blind Method; D005260:Female; D005502:Food; D006801:Humans; D008297:Male; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000502:physiology; D050781:Transcranial Magnetic Stimulation; D016896:Treatment Outcome
keywords: bulimia nervosa; craving; eating disorders; neuromodulation