title: Preparations, characterization, and biological features of mononuclear Cu(II) complexes based on hydrazone ligands.
abstract: Three mononuclear Cu(II) complexes Cu(HL1)Cl2(1), Cu(HL2)Cl2(2), and Cu(L3)SCN (3) have been synthesized based on chelating hydrazone ligands HL1, HL2, and HL3, respectively. These new compounds gave satisfactory IR-spectroscopic data and were further characterized by elemental and X-ray diffraction analyses. Their urease inhibitory evaluation was tested in vitro against jack bean urease. The results showed that the inhibitory activities of the copper complexes are all superior to the positive reference. Enzyme kinetics studies were undertaken to estimate the inhibition mechanism of the copper complexes. Molecular docking simulations have been performed to rationalize their binding models. In addition, their interactions with serum albumin were also studied.
authors.affiliation: School of Life Sciences, Shandong University of Technology, Zibo 255000, PR China. Electronic address: qinjietutu@163.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Qin
authors.affiliation: School of Life Sciences, Shandong University of Technology, Zibo 255000, PR China.
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Zhao
authors.affiliation: School of Life Sciences, Shandong University of Technology, Zibo 255000, PR China.
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Liu
authors.affiliation: School of Life Sciences, Shandong University of Technology, Zibo 255000, PR China.
authors.forename: Zhong-Wei
authors.initials: ZW
authors.lastname: Man
authors.affiliation: School of Life Sciences, Shandong University of Technology, Zibo 255000, PR China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.affiliation: School of Life Sciences, Shandong University of Technology, Zibo 255000, PR China.
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Wang
authors.affiliation: School of Life Sciences, Shandong University of Technology, Zibo 255000, PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Xu
authors.affiliation: School of Life Sciences, Shandong University of Technology, Zibo 255000, PR China; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China.
authors.forename: Hai-Liang
authors.initials: HL
authors.lastname: Zhu
mesh_terms: D003300:Copper / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006835:Hydrazones / Q000737:chemistry*; D008024:Ligands; D062105:Molecular Docking Simulation; D013055:Spectrophotometry, Infrared; D014510:Urease / Q000037:antagonists & inhibitors; D014961:X-Ray Diffraction
chemical_list: D004791:Enzyme Inhibitors; D006835:Hydrazones; D008024:Ligands; D003300:Copper; D014510:Urease
keywords: Copper(II) complex; Hydrazone ligand; Kinetics study; Serum albumin interaction; Urease inhibitors