title: Update on Ophthalmic Oncology 2014: Retinoblastoma and Uveal Melanoma.
abstract: OBJECTIVE
  The aim of this study was to review peer-reviewed articles on ophthalmic oncology (specifically retinoblastoma and uveal melanoma) published from January to December 2014.
  
  
  METHODS
  This study is a literature review.
  
  
  METHODS
  The terms retinoblastoma and uveal melanoma were used in a MEDLINE literature search. Abstracts were studied, and the most relevant articles were selected for inclusion and further in-depth review.
  
  
  RESULTS
  In retinoblastoma, more eyes are being salvaged due to intravitreal melphalan. The year 2014 marks a deepening in our understanding of the biological basis of the disease and the cell of origin. Knowledge on the genetic underpinnings of uveal melanoma has broadened to include other pathways, interactions, and potential therapeutic targets.
  
  
  CONCLUSIONS
  In 2014, there were valuable advancements in our knowledge of retinoblastoma and uveal melanoma. Some of these resulted in improved patient management.
authors.affiliation: From the *Memorial Sloan Kettering Cancer Center; and †Weill Cornell Medical Center, New York, NY.
authors.forename: Jasmine H
authors.initials: JH
authors.lastname: Francis
authors.forename: Ariana M
authors.initials: AM
authors.lastname: Levin
authors.forename: David H
authors.initials: DH
authors.lastname: Abramson
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D006801:Humans; D058449:Intravitreal Injections; D008545:Melanoma / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D009366:Neoplasm Seeding; D019572:Retinal Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D012175:Retinoblastoma / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D014604:Uveal Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D000098943:Uveal Melanoma
chemical_list: D000970:Antineoplastic Agents