title: Nosocomial sepsis: evaluation of the efficacy of preventive measures in a level-III neonatal intensive care unit.
abstract: OBJECTIVE
  To evaluate nosocomial infections preventive bundle, implemented in April 2010 in Centro Hospitalar de São João (CHSJ) Neonatal Intensive Care Unit (NICU) effectiveness.
  
  
  METHODS
  Newborns admitted to level-III NICU of CHSJ, between 1 April 2007 and 31 March 2013, with sepsis as discharge diagnosis, were selected and divided into two periods (Period 1 and 2, before and after new preventive bundle introduction). Data from the two periods were compared.
  
  
  RESULTS
  Nosocomial sepsis incidence density decreased significantly from 8.6 to 4.8 per 1000 patient days from Period 1 to 2. Nosocomial infections preventive bundle implementation led to a significant decrease in central line-associated bloodstream infections (CLABSI) rates from 14.1 to 10.4 per 1000 catheter days.
  
  
  CONCLUSIONS
  Nosocomial infections preventive bundle implemented revealed efficient in decreasing the incidence density of nosocomial sepsis. However, CLABSI rates remain high. Physicians should be alert to the need to adhere to strict infection control protocols and institute effective measures for nosocomial infection surveillance.
authors.affiliation: a Faculty of Medicine , Porto University , Porto , Portugal and.
authors.forename: Catarina Cardoso de
authors.initials: CC
authors.lastname: Almeida
authors.affiliation: a Faculty of Medicine , Porto University , Porto , Portugal and.|b Neonatal Intensive Care Unit, Centro Hospitalar de São João , Porto , Portugal.
authors.forename: Susana Maria Saraiva
authors.initials: SMS
authors.lastname: Pissarra da Silva
authors.affiliation: a Faculty of Medicine , Porto University , Porto , Portugal and.|b Neonatal Intensive Care Unit, Centro Hospitalar de São João , Porto , Portugal.
authors.forename: Filipa Silveira Dias
authors.initials: FSD
authors.lastname: Flor de Lima Caldas de Oliveira
authors.affiliation: a Faculty of Medicine , Porto University , Porto , Portugal and.|b Neonatal Intensive Care Unit, Centro Hospitalar de São João , Porto , Portugal.
authors.forename: Maria Hercília Ferreira
authors.initials: MHF
authors.lastname: Guimarães Pereira Areias
mesh_terms: D055499:Catheter-Related Infections / Q000150:complications / Q000453:epidemiology* / Q000517:prevention & control; D002405:Catheterization, Central Venous / Q000009:adverse effects; D003428:Cross Infection / Q000453:epidemiology* / Q000517:prevention & control; D005260:Female; D006801:Humans; D015994:Incidence; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D017053:Infection Control; D007363:Intensive Care Units, Neonatal / Q000592:standards / Q000706:statistics & numerical data; D008297:Male; D000071074:Neonatal Sepsis / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D010043:Outcome and Process Assessment, Health Care; D011247:Pregnancy
keywords: Bloodstream infections; central line-associated bloodstream infections; healthcare-associated infections; newborns; prevention; very low birth weight