title: HSC Contribution in Making Steady-State Blood.
abstract: In homeostasis, whether blood cells are derived from committed progenitor or mutipotent stem cell activity remains controversial. In this issue of Immunity, Sawai et al. (2016) describe murine HSCs as the major contributor to the maintenance of multilineage hematopoiesis, both in the steady state and during cytokine response.
authors.affiliation: Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: keisuke.ito@einstein.yu.edu.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Ito
authors.affiliation: Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: paul.frenette@einstein.yu.edu.
authors.forename: Paul S
authors.initials: PS
authors.lastname: Frenette
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D016207:Cytokines / Q000378:metabolism; D006410:Hematopoiesis / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000378:metabolism / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans
chemical_list: D016207:Cytokines