title: Post Thrombotic Syndrome.
abstract: Venous insufficiency following deep venous thrombosis is known as the post thrombotic syndrome. Whilst its presentation and symptoms can vary slightly between individuals, it can have a profound effect on quality of life. Symptoms range from mild limb swelling to severe intractable ulceration. A number of scoring systems have been developed to help monitor the disease progression, response to treatment as well as to classify patients for research purposes.Treatment involves a combination of therapies, including compression stockings, venous stenting for out flow obstruction and in some instances deep venous bypass. A considerable effort is made in preventing post thrombotic syndrome with a number of trials looking into the effect of prompt and stable anticoagulation, the effect of compression stockings, the effect of exercise and the outcomes following early thrombus removal strategies such as catheter directed and pharmacomechanical thrombolysis.
authors.affiliation: Academic Section of Vascular Surgery, Charing Cross Hospital, Imperial College London, London, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Busuttil
authors.affiliation: Academic Section of Vascular Surgery, Charing Cross Hospital, Imperial College London, London, UK.
authors.forename: Chung Sim
authors.initials: CS
authors.lastname: Lim
authors.affiliation: Academic Section of Vascular Surgery, Charing Cross Hospital, Imperial College London, London, UK. a.h.davies@imperial.ac.uk.
authors.forename: Alun H
authors.initials: AH
authors.lastname: Davies
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D018450:Disease Progression; D004487:Edema / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D007871:Leg Ulcer / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D061185:Mechanical Thrombolysis / Q000379:methods*; D054070:Postthrombotic Syndrome / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D011788:Quality of Life; D012720:Severity of Illness Index; D015607:Stents; D053828:Stockings, Compression; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D014812:Vitamin K / Q000037:antagonists & inhibitors / Q000097:blood
chemical_list: D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight; D014812:Vitamin K
keywords: Catheter directed thrombolysis; Chronic venous insufficiency; Post thrombotic syndrome; Ulcer; Venous hypertension; Venous outflow obstruction; Venous reflux; Venous stenting