title: Treatment of Plantar Fasciitis With Botulinum Toxin.
abstract: BACKGROUND
  This study examined the effect of botulinum toxin upon plantar fasciitis through a randomized, controlled, and blinded trial.
  
  
  METHODS
  Between 2012 and 2015, 50 patients presented with plantar fasciitis. Twenty-five patients each randomly received an IncobotulinumtoxinA (IBTA) or saline injection of their affected foot. Pre- and postinjection function and pain were graded with the Foot and Ankle Ability Measures (FAAM) and visual analog scale (VAS), respectively. All 50 study patients who randomly received either placebo or IBTA presented at 6 and 12 months after injection.
  
  
  RESULTS
  At 6 months, the mean FAAM increased from 35.9 to 40.9 of 100, and the mean pain score decreased from 8.4 to 7.9 of 10 within the placebo group. At 6 months, the mean FAAM increased from 36.3 to 73.8 of 100, and mean pain score decreased from 7.2 to 3.6 of 10 within the IBTA group. These postinjection scores were significantly better than the placebo group ( P = .01). At 12 months after injection, the IBTA group maintained significantly better function and pain than the placebo group ( P < .05). By that time, 0 (0%) and 3 (12%) patients who received IBTA and saline, respectively, underwent surgery for recalcitrant plantar fasciitis ( P < .005).
  
  
  CONCLUSIONS
  Compared with placebo saline injection, using IBTA to treat plantar fasciitis resulted in significantly better improvement in foot function and pain. IBTA also lessened the need for operative treatment of plantar fasciitis.
  
  
  METHODS
  I, Randomized, double-blinded, placebo-controlled study.
authors.affiliation: 1 Orthopaedic Foot and Ankle Surgery, Rothman Institute Orthopaedics, Philadelphia, PA, USA.
authors.forename: Jamal
authors.initials: J
authors.lastname: Ahmad
authors.affiliation: 2 Department of Anatomy, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA.
authors.forename: Stacy H
authors.initials: SH
authors.lastname: Ahmad
authors.affiliation: 3 Rothman Institute Orthopaedics, Philadelphia, PA.
authors.forename: Kennis
authors.initials: K
authors.lastname: Jones
mesh_terms: D000328:Adult; D000368:Aged; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage*; D004311:Double-Blind Method; D036981:Fasciitis, Plantar / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000008:administration & dosage*; D010147:Pain Measurement; D011446:Prospective Studies; D012965:Sodium Chloride / Q000008:administration & dosage
chemical_list: D009465:Neuromuscular Agents; D012965:Sodium Chloride; D019274:Botulinum Toxins, Type A; C545476:incobotulinumtoxinA
keywords: IncobotulinumtoxinA; botulinum toxin; placebo; plantar fasciitis