title: Luminescent iminophosphorane gold, palladium and platinum complexes as potential anticancer agents.
abstract: A series of coordination gold(III), palladium(II), and platinum(II) complexes with a luminescent iminophosphorane ligand derived from 8-aminoquinoline [Ph3P=N-C9H6N] (1), have been synthesized and structurally characterized. The coordination palladium(II) and platinum(II) compounds can evolve further, under appropriate conditions, to give stable cyclometalatedendospecies [M{κ3-C,N,N-C6H4(PPh2=N-8-C9H6N}Cl] (M = Pd, Pt) by C-H activation of the phenyl group of the PPh3fragment. Iminophosphorane1and the new metallic complexes are luminescent in DMSO or DMSO:H2O (1:1 mixture) solutions at RT. The compounds have been evaluated for their antiproliferative properties in a human ovarian cancer cell line (A2780S), in human lung cancer cells (A-549) and in a non-tumorigenic human embryonic kidney cell line (HEK-293T). Most compounds have been more toxic to the ovarian cancer cell line than to the non-tumorigenic cell line. The new complexes interact with human serum albumin (HSA) faster than cisplatin. Studies of the interactions of the compounds with DNA indicate that, in some cases, they exert anticancer effectsin vitrobased on different mechanisms of action with respect to cisplatin.
authors.affiliation: Department of Chemistry, Brooklyn College and The Graduate Center, The City University of New York, Brooklyn, NY, 11210, US.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Frik
authors.affiliation: Departamento de Química Inorgánica, Facultad de Ciencias-Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), Universidad de Zaragoza-CSIC, Pedro Cerbuna 12, 50009 Zaragoza, Spain.
authors.forename: Josefina
authors.initials: J
authors.lastname: Jiménez
authors.affiliation: Department of Chemistry, Brooklyn College and The Graduate Center, The City University of New York, Brooklyn, NY, 11210, US.
authors.forename: Vadim
authors.initials: V
authors.lastname: Vasilevski
authors.affiliation: Department of Chemistry, Brooklyn College and The Graduate Center, The City University of New York, Brooklyn, NY, 11210, US.
authors.forename: Monica
authors.initials: M
authors.lastname: Carreira
authors.affiliation: Dept. of Pharmacokinetics, Toxicology and Targeting, Research Institute of Pharmacy, University of Groningen, 9713 AV Groningen, The Netherlands.
authors.forename: Andreia
authors.initials: A
authors.lastname: de Almeida
authors.affiliation: Departamento de Química Inorgánica, Facultad de Ciencias-Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), Universidad de Zaragoza-CSIC, Pedro Cerbuna 12, 50009 Zaragoza, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Gascón
authors.affiliation: Department of Chemistry, Brooklyn College and The Graduate Center, The City University of New York, Brooklyn, NY, 11210, US.
authors.forename: Farrah
authors.initials: F
authors.lastname: Benoit
authors.affiliation: Departamento de Química Inorgánica, Universidad de Valencia, Burjassot, Valencia, 46100, Spain.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Sanaú
authors.affiliation: Dept. of Pharmacokinetics, Toxicology and Targeting, Research Institute of Pharmacy, University of Groningen, 9713 AV Groningen, The Netherlands.
authors.forename: Angela
authors.initials: A
authors.lastname: Casini
authors.affiliation: Department of Chemistry, Brooklyn College and The Graduate Center, The City University of New York, Brooklyn, NY, 11210, US.
authors.forename: María
authors.initials: M
authors.lastname: Contel