title: Matrix Metalloproteinase-9 -1562C/T Gene Polymorphism Is Associated with Diabetic Nephropathy.
abstract: To investigate the association between the metalloproteinase-9 (MMP9) -1562C/T polymorphism and diabetic nephropathy (DN) in Han Chinese, the patients with type 2 diabetes were collected and divided into the non-DN (NDN) and DN groups; controls were recruited. Genotype and allele frequencies were assessed using polymerase chain reaction and restriction fragment length polymorphism. Results showed that SBP, DBP, HbA1c, UAER, Cr, BUN, TG, and TC were higher in the DN group compared with the control and NDN groups. SBP, HbA1c, and TC in DN patients with the TT and CT genotypes were lower than in those with CC. Compared with controls, the frequency of the T allele in the DN group was significantly lower. The MMP9 -1562C allele, SBP, Cr, BUN, TG, and TC were independent risk factors for DN. All of the above suggested that the MMP9 -1562C/T polymorphism was associated with DN in Han Chinese.
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
authors.forename: Shufen
authors.initials: S
authors.lastname: Feng
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Ye
authors.affiliation: Clinical Laboratory, People's Hospital of New District Longhua, Shenzhen 518109, China.
authors.forename: Shi
authors.initials: S
authors.lastname: Bai
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
authors.forename: Hongcheng
authors.identifier: 0000-0002-4863-7831
authors.initials: H
authors.lastname: Wei
authors.affiliation: Department of Nephrology, Affiliated Hospital of Guilin Medical College, Guangxi 541001, China.
authors.forename: Xueling
authors.initials: X
authors.lastname: Liao
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D003928:Diabetic Nephropathies / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D008875:Middle Aged; D015999:Multivariate Analysis; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
chemical_list: C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9