title: 4-Fluoro-N'-(2-hydroxy-3-methoxybenzylidene) benzohydrazide and its Oxidovanadium(V) Complex: Syntheses, Crystal Structures and Insulin-enhancing Activity.
abstract: A hydrated hydrazone compound, 4-fluoro-N'-(2-hydroxy-3-methoxybenzylidene)benzohydrazide monohydrate (H2L · H2O), was prepared and characterized by elemental analysis, HRMS, IR, UV-Vis and 1H NMR spectroscopy. Reaction of H2L, kojic acid (5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one; Hka) and VO(acac)2 in methanol afforded a novel oxidovanadium(V) complex, [VO(ka)L]. The complex was characterized by elemental analysis, IR, UV-Vis and 1H NMR spectroscopy. Thermal analysis was also performed. Structures of H2L and the complex were further confirmed by single crystal structural X-ray diffraction. The vanadium complex is the first structurally characterized vanadium complex of kojic acid. Insulin-mimetic tests on C2C12 muscle cells indicate that the complex significantly stimulated cell glucose utilization with cytotoxicity at 0.11 g L-1.
authors.forename: Jin-Xian
authors.initials: JX
authors.lastname: Lei
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Yang
authors.initials: Y
authors.lastname: Huo
authors.forename: Zhonglu
authors.initials: Z
authors.lastname: You
mesh_terms: D000818:Animals; D002460:Cell Line; D018360:Crystallography, X-Ray; D005947:Glucose / Q000378:metabolism; D006835:Hydrazones / Q000737:chemistry*; D007328:Insulin / Q000096:biosynthesis*; D051379:Mice; D015394:Molecular Structure; D018482:Muscle, Skeletal / Q000166:cytology / Q000378:metabolism; D017968:Vanadium Compounds / Q000737:chemistry*
chemical_list: D006835:Hydrazones; D007328:Insulin; D017968:Vanadium Compounds; D005947:Glucose