title: The multifaceted roles of fatty acid synthesis in cancer.
abstract: Lipid metabolism, in particular the synthesis of fatty acids (FAs), is an essential cellular process that converts nutrients into metabolic intermediates for membrane biosynthesis, energy storage and the generation of signalling molecules. This Review explores how different aspects of FA synthesis promote tumorigenesis and tumour progression. FA synthesis has received substantial attention as a potential target for cancer therapy, but strategies to target this process have not yet translated into clinical practice. Furthermore, efforts to target this pathway must consider the influence of the tumour microenvironment.
authors.affiliation: Department of Biochemistry and Molecular Biology, Theodor Boveri Institute, Biocenter, Am Hubland, 97074 Würzburg, Germany.|Comprehensive Cancer Center Mainfranken, Josef-Schneider-Strasse 6, 97080 Würzburg, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Röhrig
authors.affiliation: Department of Biochemistry and Molecular Biology, Theodor Boveri Institute, Biocenter, Am Hubland, 97074 Würzburg, Germany.|Comprehensive Cancer Center Mainfranken, Josef-Schneider-Strasse 6, 97080 Würzburg, Germany.
authors.forename: Almut
authors.initials: A
authors.lastname: Schulze
mesh_terms: D063646:Carcinogenesis / Q000378:metabolism*; D018450:Disease Progression; D005227:Fatty Acids / Q000096:biosynthesis* / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology; D009369:Neoplasms / Q000378:metabolism*; D051779:Sterol Regulatory Element Binding Proteins / Q000378:metabolism; D059016:Tumor Microenvironment / Q000502:physiology
chemical_list: D005227:Fatty Acids; D051779:Sterol Regulatory Element Binding Proteins