title: The Role of 18F-Sodium Fluoride PET/CT Bone Scans in the Diagnosis of Metastatic Bone Disease from Breast and Prostate Cancer.
abstract: We describe the role of18F-sodium fluoride (18F-NaF) PET/CT bone scanning in the staging of breast and prostate cancer.18F-NaF PET was initially utilized as a bone scanning agent in the 1960s and early 1970s, however, its use was restricted by the then-available γ-cameras. The advent of hybrid PET/CT cameras in the late 1990s has shown a resurgence of interest in its use and role. After a brief introduction, this paper describes the radiopharmaceutical properties, dosimetry, pharmacokinetics, and mechanism of uptake of18F-NaF. The performance of18F-NaF PET/CT is then compared with that of conventional bone scintigraphy using current evidence from the literature. Strengths and weaknesses of18F-NaF PET/CT imaging are highlighted. Clinical examples of improved accuracy of diagnosis and impact on patient management are illustrated. Limitations of18F-NaF PET/CT imaging are outlined.
authors.affiliation: Queensland X-Ray, Cairns Private Hospital, Cairns, Australia rkul22@gmail.com.
authors.forename: Randeep Kumar
authors.initials: RK
authors.lastname: Kulshrestha
authors.affiliation: Department of Nuclear Medicine, Royal Liverpool Hospital, Liverpool, United Kingdom; and.
authors.forename: Sobhan
authors.initials: S
authors.lastname: Vinjamuri
authors.affiliation: School of Health Sciences, University of Salford, Salford, United Kingdom.
authors.forename: Andrew
authors.initials: A
authors.lastname: England
authors.affiliation: School of Health Sciences, University of Salford, Salford, United Kingdom.
authors.forename: Julie
authors.initials: J
authors.lastname: Nightingale
authors.affiliation: School of Health Sciences, University of Salford, Salford, United Kingdom.
authors.forename: Peter
authors.initials: P
authors.lastname: Hogg
mesh_terms: D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary*; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D001943:Breast Neoplasms / Q000473:pathology*; D005462:Fluorine Radioisotopes; D006801:Humans; D008297:Male; D000072078:Positron Emission Tomography Computed Tomography; D011471:Prostatic Neoplasms / Q000473:pathology*; D011874:Radiometry; D012969:Sodium Fluoride / Q000493:pharmacokinetics
chemical_list: D005462:Fluorine Radioisotopes; D012969:Sodium Fluoride
keywords: 18F-sodium fluoride PET/CT; 99mTc-MDP; bone metastases; bone scintigraphy; breast cancer; prostate cancer