title: Microencapsulated krill and tuna oil blend raises plasma long-chain n-3 polyunsaturated fatty acid levels compared to tuna oil with similar increases in ileal contractility in rats.
abstract: Long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) may be more bioavailable from krill oil compared to fish oil due to their phospholipid structure. We tested whether a microencapsulated krill and tuna oil blend (ME-TOKO) provided greater LC n-3 PUFA bioavailability, improved blood lipid profiles and increased intestinal contractility compared to microencapsulated tuna oil (ME-TO). Rats were divided into three groups to receive isocaloric diets containing ME-TO, ME-TOKO and microencapsulated olive oil (ME-OO) at 0.3 or 2 g/100 g for 4 weeks. Final body and organ weights, feed intake and waste output were similar. ME-TOKO rats had higher plasma total LC n-3 PUFA levels compared to ME-TO, but liver LC n-3 PUFA levels and plasma triglyceride and cholesterol levels were similar in non-fasted rats. Diets containing 2% ME-TO and ME-TOKO also showed similar increases in ileal contractility. In summary, ME-TO bioavailability of LC n-3 PUFA was similar to ME-TOKO.
authors.affiliation: a CSIRO Health and Biosecurity , Kintore Avenue , Adelaide South Australia , Australia.
authors.forename: Glen S
authors.initials: GS
authors.lastname: Patten
authors.affiliation: b CSIRO Agriculture , Sneydes Road , Werribee Victoria , Australia.
authors.forename: Luz
authors.initials: L
authors.lastname: Sanguansri
authors.affiliation: b CSIRO Agriculture , Sneydes Road , Werribee Victoria , Australia.
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Augustin
authors.affiliation: a CSIRO Health and Biosecurity , Kintore Avenue , Adelaide South Australia , Australia.
authors.forename: Mahinda Y
authors.initials: MY
authors.lastname: Abeywardena
authors.affiliation: a CSIRO Health and Biosecurity , Kintore Avenue , Adelaide South Australia , Australia.
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Bird
authors.affiliation: c The Omega-3 Centre , University of Wollongong , Wollongong , New South Wales , Australia.
authors.forename: Craig S
authors.initials: CS
authors.lastname: Patch
authors.affiliation: a CSIRO Health and Biosecurity , Kintore Avenue , Adelaide South Australia , Australia.
authors.forename: Damien P
authors.initials: DP
authors.lastname: Belobrajdic
mesh_terms: D000818:Animals; D001682:Biological Availability; D002784:Cholesterol / Q000097:blood; D004032:Diet; D004339:Drug Compounding; D033201:Euphausiacea; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000097:blood*; D005395:Fish Oils / Q000737:chemistry*; D007082:Ileum / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D010743:Phospholipids / Q000378:metabolism; D011208:Powders; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood; D014413:Tuna
chemical_list: D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D010743:Phospholipids; D011208:Powders; D014280:Triglycerides; D002784:Cholesterol
keywords: Microencapsulation; bioavailability; gut contractility; krill; lipids; liver; oil; plasma; tuna