title: Strategies to develop vaccines of pediatric interest.
abstract: The success of the vaccines available on the market has significantly increased interest in vaccine development. Areas covered: The main aim of this paper is to discuss the most important vaccines of pediatric interest that are currently being developed. New pneumococcal vaccines and vaccines against group B Streptococcus, Staphylococcus aureus and respiratory syncytial virus are analyzed in detail. Expert commentary: Advances in understanding human immunology, including human monoclonal antibody identification, sequencing technology, and the ability to solve atomic level structures of vaccine targets have provided tools to guide the rational design of future vaccines. It is likely that some of these vaccines will reach the market in the future and will thus partially contribute to the prevention of very severe diseases that significantly affect the morbidity and mortality of children. However, further studies in animals and several clinical trials in children must be performed before new vaccines become licensed.
authors.affiliation: a Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation , Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico , Milan , Italy.
authors.forename: Susanna
authors.initials: S
authors.lastname: Esposito
authors.affiliation: a Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation , Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico , Milan , Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Principi
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000382:microbiology / Q000517:prevention & control*; D001428:Bacterial Vaccines / Q000276:immunology* / Q000302:isolation & purification*; D004195:Disease Models, Animal; D055808:Drug Discovery / Q000639:trends; D004353:Drug Evaluation, Preclinical; D006801:Humans; D012136:Respiratory Syncytial Viruses / Q000276:immunology; D013211:Staphylococcus aureus / Q000276:immunology; D013292:Streptococcus agalactiae / Q000276:immunology; D013296:Streptococcus pneumoniae / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology* / Q000302:isolation & purification*; D014777:Virus Diseases / Q000517:prevention & control* / Q000821:virology
chemical_list: D001428:Bacterial Vaccines; D014765:Viral Vaccines
keywords: Children; RSV; Staphylococcus aureus; Streptococcus pneumoniae; group B Streptococcus; prevention; vaccine