title: Reinventing HCV Treatment: Past and Future Perspectives.
abstract: This review paper summarizes the epidemiology of hepatitis C virus (HCV) and chronic HCV infection, including HCV virology and treatment regimens. Specifically, we focus on the evolution of past, current, and future HCV treatment options, the reasons for treatment failure, and the impact of resistance-associated variants on treatment success.
authors.affiliation: Food and Drug Administration, Center for Drug Evaluation and Research, Office of New Drugs, Division of Antiviral Products, Silver Spring, MD, USA.
authors.forename: Wendy
authors.initials: W
authors.lastname: Carter
authors.affiliation: Food and Drug Administration, Center for Drug Evaluation and Research, Office of New Drugs, Division of Antiviral Products, Silver Spring, MD, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Connelly
authors.affiliation: Food and Drug Administration, Center for Drug Evaluation and Research, Office of New Drugs, Division of Antiviral Products, Silver Spring, MD, USA.
authors.forename: Kimberly
authors.initials: K
authors.lastname: Struble
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D016174:Hepacivirus / Q000235:genetics / Q000378:metabolism; D019698:Hepatitis C, Chronic / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology*; D006801:Humans; D007372:Interferons / Q000737:chemistry / Q000627:therapeutic use; D010750:Phosphoproteins / Q000037:antagonists & inhibitors; D011480:Protease Inhibitors / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D012254:Ribavirin / Q000627:therapeutic use; D057057:Serine Proteases; D000072230:Sustained Virologic Response; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors; D012324:RNA-Dependent RNA Polymerase
chemical_list: D000998:Antiviral Agents; D007372:Interferons; D010750:Phosphoproteins; D011480:Protease Inhibitors; D012254:Ribavirin; D057057:Serine Proteases; D017361:Viral Nonstructural Proteins; C532378:nonstructural phosphoprotein 5A, GB virus type C; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase; C000614516:NS3-4A serine protease, Hepatitis C virus
keywords: direct-acting antivirals; genotype; hepatitis C; resistance-associated variants; sustained virologic response