title: Small molecule compounds that induce cellular senescence.
abstract: To date, dozens of stress-induced cellular senescence phenotypes have been reported. These cellular senescence states may differ substantially from each other, as well as from replicative senescence through the presence of specific senescence features. Here, we attempted to catalog virtually all of the cellular senescence-like states that can be induced by low molecular weight compounds. We summarized biological markers, molecular pathways involved in senescence establishment, and specific traits of cellular senescence states induced by more than fifty small molecule compounds.
authors.affiliation: Institute of Gene Biology RAS, 34/5 Vavilova Street, 119334, Moscow, Russia.
authors.forename: Nadezhda V
authors.initials: NV
authors.lastname: Petrova
authors.affiliation: Institute of Gene Biology RAS, 34/5 Vavilova Street, 119334, Moscow, Russia.
authors.forename: Artem K
authors.initials: AK
authors.lastname: Velichko
authors.affiliation: Institute of Gene Biology RAS, 34/5 Vavilova Street, 119334, Moscow, Russia.|Department of Molecular Biology, Lomonosov Moscow State University, 119991, Moscow, Russia.|LIA 1066 French-Russian Joint Cancer Research Laboratory, 94805, Villejuif, France.
authors.forename: Sergey V
authors.initials: SV
authors.lastname: Razin
authors.affiliation: Institute of Gene Biology RAS, 34/5 Vavilova Street, 119334, Moscow, Russia.|LIA 1066 French-Russian Joint Cancer Research Laboratory, 94805, Villejuif, France.
authors.forename: Omar L
authors.initials: OL
authors.lastname: Kantidze
keywords: DNA damage; DNA replication stress; aging; cell stress; cellular senescence; epigenetic modifiers