title: Functional segregation and integration within fronto-parietal networks.
abstract: Experimental data on monkeys and functional studies in humans support the existence of a complex fronto-parietal system activating for cognitive and motor tasks, which may be anatomically supported by the superior longitudinal fasciculus (SLF). Advanced tractography methods have recently allowed the separation of the three branches of the SLF but are not suitable for their functional investigation. In order to gather comprehensive information about the functional organisation of these fronto-parietal connections, we used an innovative method, which combined tractography of the SLF in the largest dataset so far (129 participants) with 14 meta-analyses of functional magnetic resonance imaging (fMRI) studies. We found that frontal and parietal functions can be clustered into a dorsal spatial/motor network associated with the SLF I, and a ventral non-spatial/motor network associated with the SLF III. Further, all the investigated functions activated a middle network mostly associated with the SLF II. Our findings suggest that dorsal and ventral fronto-parietal networks are segregated but also share regions of activation, which may support flexible response properties or conscious processing. In sum, our novel combined approach provided novel findings on the functional organisation of fronto-parietal networks, and may be successfully applied to other brain connections.
authors.affiliation: Sackler Institute of Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, SE5 8AF London, UK; Natbrainlab, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, SE5 8AF London, UK. Electronic address: valeria.parlatini@kcl.ac.uk.
authors.forename: Valeria
authors.initials: V
authors.lastname: Parlatini
authors.affiliation: Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, SE5 8AF London, UK; FIDMAG Germanes Hospitalàries, CIBERSAM, Sant Boi de Llobregat 08035, Spain.
authors.forename: Joaquim
authors.initials: J
authors.lastname: Radua
authors.affiliation: Natbrainlab, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, SE5 8AF London, UK; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, SE5 8AF London, UK; NIHR Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and King's College London, Institute of Psychiatry, SE5 8AF London, UK.
authors.forename: Flavio
authors.initials: F
authors.lastname: Dell'Acqua
authors.affiliation: Natbrainlab, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, SE5 8AF London, UK; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, SE5 8AF London, UK; NIHR Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and King's College London, Institute of Psychiatry, SE5 8AF London, UK.
authors.forename: Anoushka
authors.initials: A
authors.lastname: Leslie
authors.affiliation: Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, SE5 8AF London, UK; NIHR Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and King's College London, Institute of Psychiatry, SE5 8AF London, UK; MRC Centre for Neurodegeneration Research, King's College London, SE5 9RX London, UK.
authors.forename: Andy
authors.initials: A
authors.lastname: Simmons
authors.affiliation: Sackler Institute of Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, SE5 8AF London, UK.
authors.forename: Declan G
authors.initials: DG
authors.lastname: Murphy
authors.affiliation: Sackler Institute of Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, SE5 8AF London, UK; Natbrainlab, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, SE5 8AF London, UK.
authors.forename: Marco
authors.initials: M
authors.lastname: Catani
authors.affiliation: Sackler Institute of Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, SE5 8AF London, UK; Natbrainlab, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, SE5 8AF London, UK; Brain Connectivity Behaviour group, FrontLab, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, Inserm, CNRS, Institut du cerveau et la moelle (ICM) - Hôpital Pitié-Salpêtrière, Boulevard de l'hôpital, F-75013, Paris, France. Electronic address: michel.thiebaut@gmail.com.
authors.forename: Michel
authors.initials: M
authors.lastname: Thiebaut de Schotten
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001931:Brain Mapping; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D005625:Frontal Lobe / Q000033:anatomy & histology* / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology; D010296:Parietal Lobe / Q000033:anatomy & histology* / Q000502:physiology*; D066127:White Matter / Q000033:anatomy & histology* / Q000502:physiology*; D055815:Young Adult
keywords: Diffusion tractography; Frontal parietal; Functional magnetic resonance imaging (fMRI); Meta-analysis; Superior longitudinal fasciculus