title: Acute Motor-dominant Polyneuropathy as Guillain-Barré Syndrome and Multiple Mononeuropathies in a Patient with Sjögren's Syndrome.
abstract: A patient with xerostomia and xerophthalmia due to Sjögren's syndrome presented with acute motor-dominant polyneuropathy and multiple mononeuropathy with antiganglioside antibodies. Nerve conduction studies and a sural nerve biopsy revealed the neuropathy as a mixture of segmental demyelination and axonal degeneration. Positive results were obtained for several antiganglioside antibodies. Corticosteroid treatment proved effective. The neuropathy was considered to represent a mixture of polyneuropathy as Guillain-Barré syndrome and multiple mononeuropathy via Sjögren's syndrome. We speculate that Guillain-Barré syndrome occurred in the patient and Guillain-Barré syndrome itself activated multiple mononeuropathy via Sjögren's syndrome.
authors.affiliation: Department of Neurology, Tottori Prefectural Central Hospital, Japan.
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Tanaka
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakayasu
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Suto
authors.forename: Shotaro
authors.initials: S
authors.lastname: Takahashi
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Konishi
authors.forename: Hirotake
authors.initials: H
authors.lastname: Nishimura
authors.forename: Rino
authors.initials: R
authors.lastname: Ueno
authors.forename: Susumu
authors.initials: S
authors.lastname: Kusunoki
authors.forename: Kenji
authors.initials: K
authors.lastname: Nakashima
mesh_terms: D020275:Guillain-Barre Syndrome / Q000150:complications / Q000276:immunology / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020422:Mononeuropathies / Q000150:complications / Q000276:immunology / Q000503:physiopathology*; D009431:Neural Conduction / Q000502:physiology; D012859:Sjogren's Syndrome / Q000150:complications / Q000276:immunology / Q000503:physiopathology*; D014987:Xerostomia / Q000150:complications