title: Obesity, Serum Resistin and Leptin Levels Linked to Coronary Artery Disease.
abstract: BACKGROUND
  Clinical studies have demonstrated that adipocytokines play an important role in developing atherosclerotic cardiovascular diseases.
  
  
  OBJECTIVE
  The aim of study was to evaluate the relationship between serum resistin and leptin levels with obesity and coronary artery disease (CAD).
  
  
  METHODS
  In a cross-sectional study, we assessed the levels of serum resistin and leptin, C-reactive protein (CRP), lipid profile and cardiac enzyme tests (AST, CPK, LDH, CK-MB) in 40 CAD patients compared to 40 healthy controls. Anthropometric measurements including weight and height for calculating of body mass index (BMI), and waist circumference (WC) were performed for evaluation of obesity.
  
  
  RESULTS
  CAD patients had increased levels of leptin and CRP, (p < 0.001), cholesterol (p < 0.05), triglyceride (p < 0.01), and WC (p < 0.05) compared to healthy controls. There was no statistical difference between CAD and control subjects for resistin (p = 0.058). In a multiple regression analysis, only an association between serum leptin with BMI (β = 0.480, p < 0.05) and WC (β = 1.386, p < 0.05) was found.
  
  
  CONCLUSIONS
  The findings suggest that leptin is a better marker of fat mass value than resistin and may be considered an independent risk factor for cardiac disorders that is largely dependent on obesity. However, further prospective studies are needed to confirm these results.
authors.affiliation: Departament of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Montazerifar
authors.affiliation: School of Medicine, Zahedan University of Medical Sciences, Iran.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Bolouri
authors.affiliation: School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: Raheleh Sharifian
authors.initials: RS
authors.lastname: Paghalea
authors.affiliation: School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: Mahbubeh Khodadadpour
authors.initials: MK
authors.lastname: Mahani
authors.affiliation: Departament of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: Mansour
authors.initials: M
authors.lastname: Karajibani
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000886:Anthropometry; D001219:Aspartate Aminotransferases / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood*; D003402:Creatine Kinase / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D012016:Reference Values; D012044:Regression Analysis; D052243:Resistin / Q000097:blood*; D012307:Risk Factors; D018709:Statistics, Nonparametric; D014280:Triglycerides / Q000097:blood
chemical_list: D020738:Leptin; D052243:Resistin; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase