title: Late Cardiac Events after Childhood Cancer: Methodological Aspects of the Pan-European Study PanCareSurFup.
abstract: OBJECTIVE
  Childhood cancer survivors are at high risk of long-term adverse effects of cancer and its treatment, including cardiac events. The pan-European PanCareSurFup study determined the incidence and risk factors for cardiac events among childhood cancer survivors. The aim of this article is to describe the methodology of the cardiac cohort and nested case-control study within PanCareSurFup.
  
  
  METHODS
  Eight data providers in Europe participating in PanCareSurFup identified and validated symptomatic cardiac events in their cohorts of childhood cancer survivors. Data on symptomatic heart failure, ischemia, pericarditis, valvular disease and arrhythmia were collected and graded according to the Criteria for Adverse Events. Detailed treatment data, data on potential confounders, lifestyle related risk factors and general health problems were collected.
  
  
  RESULTS
  The PanCareSurFup cardiac cohort consisted of 59,915 5-year childhood cancer survivors with malignancies diagnosed between 1940 and 2009 and classified according to the International Classification of Childhood Cancer 3. Different strategies were used to identify cardiac events such as record linkage to population/ hospital or regional based databases, and patient- and general practitioner-based questionnaires.
  
  
  CONCLUSIONS
  The cardiac study of the European collaborative research project PanCareSurFup will provide the largest cohort of 5-year childhood cancer survivors with systematically ascertained and validated data on symptomatic cardiac events. The result of this study can provide information to minimize the burden of cardiac events in childhood cancer survivors by tailoring the follow-up of childhood cancer survivors at high risk of cardiac adverse events, transferring this knowledge into evidence-based clinical practice guidelines and providing a platform for future research studies in childhood cancer patients. .
authors.affiliation: Department of Pediatric Oncology, Emma Children's Hospital/ Academic Medical Center Amsterdam, meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.
authors.forename: Elizabeth A M
authors.initials: EA
authors.lastname: Feijen
authors.affiliation: Department of Pediatric Oncology, Emma Children's Hospital/ Academic Medical Center Amsterdam, meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.
authors.forename: Anna
authors.initials: A
authors.lastname: Font-Gonzalez
authors.affiliation: Department of Pediatric Oncology, Emma Children's Hospital/ Academic Medical Center Amsterdam, meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.
authors.forename: Elvira C
authors.initials: EC
authors.lastname: van Dalen
authors.affiliation: Department of Pediatric Oncology, Emma Children's Hospital/ Academic Medical Center Amsterdam, meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.|Department of Medical Oncology, Academic Medical Center Amsterdam, meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.
authors.forename: Helena J H
authors.initials: HJ
authors.lastname: van der Pal
authors.affiliation: Department of Medical Oncology, Academic Medical Center Amsterdam, meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.
authors.forename: Raoul C
authors.initials: RC
authors.lastname: Reulen
authors.affiliation: Department of Medical Oncology, Academic Medical Center Amsterdam, meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.
authors.forename: David L
authors.initials: DL
authors.lastname: Winter
authors.affiliation: Swiss Childhood Cancer Registry, Institute of Social and Preventive Medicine, University of Bern, Finkenhubelweg 11, 3012, Bern, Switzerland.
authors.forename: Claudia E
authors.initials: CE
authors.lastname: Kuehni
authors.affiliation: Epidemiology and Biostatistics Section, Gaslini Children Hospital, Via Gerolamo Gaslini, 5, 16148, Genova, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Haupt
authors.affiliation: Childhood Cancer Registry of Piedmont, Cancer Epidemiology Unit, Citta' della Salute e della Scienza Hospital-University of Turin and Center for Cancer Prevention (CPO), Via Santena 7, 10126, Torino, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Alessi
authors.affiliation: Boyne Research Institute, Tiernan House, Fair Green, Drogheda, Ireland.
authors.forename: Julianne
authors.initials: J
authors.lastname: Byrne
authors.affiliation: 2nd Department of Pediatrics, Semmelweis University, Üllői út 26, 1085, Budapest, Hungary.
authors.forename: Edit
authors.initials: E
authors.lastname: Bardi
authors.affiliation: Department of Pediatric Oncology, Markusovszky Hospital, Markusovszky Lajos u. 5, 9700, Szombathely, Hungary.
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Jakab
authors.affiliation: German Childhood Cancer Registry (GCCR), Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center, Mainz, Germany.
authors.forename: Desiree
authors.initials: D
authors.lastname: Grabow
authors.affiliation: Department of Pediatrics, Skåne University Lund, Getingevägen 4, 222 41, Lund, Sweden.
authors.forename: Stanislaw
authors.initials: S
authors.lastname: Garwicz
authors.affiliation: Pediatric Hematology Unit, San Gerardo Hospital, Via Primo Maggio, 22, 38089, Monza, Italy.
authors.forename: Momcilo
authors.initials: M
authors.lastname: Jankovic
authors.affiliation: Department of Paediatric and Adolescent Haematology and Oncology, and Children's BMT Unit, Great North Children's Hospital, Newcastle, United Kingdom.
authors.forename: Gill A
authors.initials: GA
authors.lastname: Levitt
authors.affiliation: Department of Paediatric and Adolescent Haematology and Oncology, and Children's BMT Unit, Great North Children's Hospital, and Northern Institute of Cancer Research, Newcastle University, Newcastle, United Kingdom.
authors.forename: Roderick
authors.initials: R
authors.lastname: Skinner
authors.affiliation: Division of Radiotherapy, Institute of Oncology, Zaloška cesta 2 SI- 1000, Ljubljana, Slovenia.
authors.forename: Lorna
authors.initials: L
authors.lastname: Zadravec Zaletel
authors.affiliation: Department of Pediatrics, Skåne University Lund, Getingevägen 4, 222 41, Lund, Sweden.
authors.forename: Lars
authors.initials: L
authors.lastname: Hjorth
authors.affiliation: Department of Pediatric Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
authors.forename: Wim J E
authors.initials: WJ
authors.lastname: Tissing
authors.affiliation: Radiation Epidemiology Group, Gustave Roussy, Inserm, UMR1018, Villejuif, France.
authors.forename: Florent
authors.initials: F
authors.lastname: de Vathaire
authors.affiliation: Department of Public Health, Epidemiology and Biostatistics, Centre for Childhood Cancer Survivor Studies, School of Health and Population Sciences, Public Health Building, University of Birmingham, Birmingham, B15 2TT, United Kingdom.
authors.forename: Mike M
authors.initials: MM
authors.lastname: Hawkins
authors.affiliation: Department of Pediatric Oncology, Emma Children's Hospital/ Academic Medical Center Amsterdam, meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.
authors.forename: Leontien C M
authors.initials: LC
authors.lastname: Kremer
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005060:Europe / Q000453:epidemiology; D006331:Heart Diseases / Q000453:epidemiology*; D006801:Humans; D007223:Infant; D009369:Neoplasms / Q000150:complications*; D012307:Risk Factors; D017741:Survivors; D055815:Young Adult