title: Head and neck inflammatory pseudotumor: Case series and review of the literature.
abstract: Inflammatory pseudotumor (IP) is an uncommon idiopathic lesion that often imitates malignancy clinically and radiologically. Inflammatory pseudotumors have been found to occur in various sites but rarely in the head and neck. The histopathology, imaging, and treatment of three unique cases of head and neck inflammatory pseudotumors are described in this case series. Patients in Cases 1 and 2 presented with right level II neck mass and left parotid tail mass, respectively. The patient in Case 3 presented with otalgia, jaw pain and trismus, and a left parapharyngeal space mass. The tumors in Cases 1 and 3 significantly decreased in size with tapered courses of oral corticosteroids. The tumor in Case 2 was surgically excised without disease recurrence. Malignancy must be ruled out with incisional or excisional biopsy. Treatment includes surgical excision, oral corticosteroids, or both. The literature shows that radiotherapy and small-molecule inhibitors may be promising alternatives.
authors.affiliation: Department of Head and Neck Surgery, MD Anderson Cancer Center, The University of Texas Medical School at Houston, USA.
authors.forename: Sagar
authors.initials: S
authors.lastname: Kansara
authors.affiliation: Department of Pathology, MD Anderson Cancer Center, USA.
authors.forename: Diana
authors.initials: D
authors.lastname: Bell
authors.affiliation: Department of Diagnostic Radiology, MD Anderson Cancer Center, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Johnson
authors.affiliation: Department of Head and Neck Surgery, MD Anderson Cancer Center, USA MZafereo@mdanderson.org.
authors.forename: Mark
authors.initials: M
authors.lastname: Zafereo
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D005260:Female; D006104:Granuloma, Plasma Cell / Q000150:complications* / Q000000981:diagnostic imaging; D006257:Head / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009302:Nasopharyngeal Diseases / Q000150:complications* / Q000000981:diagnostic imaging; D009333:Neck / Q000000981:diagnostic imaging / Q000473:pathology*; D016727:Orbital Pseudotumor / Q000150:complications* / Q000000981:diagnostic imaging
chemical_list: D015703:Antigens, CD
keywords: Head and neck neoplasms; IgG4 disease; head and neck oncology; inflammatory pseudotumor