title: Acute Myocardial Infarction Caused by Thrombotic Microangiopathy Complicated With Myelodysplastic Syndrome.
abstract: Thrombotic microangiopathy (TMA) is a rare but lethal multisystem disease characterized by peripheral thrombocytopenia, microangiopathic hemolytic anemia, fever, and various stages of renal and neurological dysfunctions.(1,2)) The causes of TMA are mainly thrombotic thrombocytopenic purpura (TTP) or hemolytic-uremic syndrome (HUS), and cases of TMA related to myelodysplastic syndrome (MDS) are quite rare. Herein, we report a case of acute myocardial infarction (AMI) caused by TMA which is strongly suspected to have a relationship to MDS, and discuss the treatment of our patient who needed antiplatelet or anticoagulant therapy after AMI, while on the other hand, had pancytopenia and a bleeding event due to MDS.
authors.affiliation: Third Department of Internal Medicine, Teikyo University Chiba Medical Center.
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Oshima
authors.forename: Masayasu
authors.initials: M
authors.lastname: Ikutomi
authors.forename: Hiroki
authors.initials: H
authors.lastname: Shinohara
authors.forename: Jumpei
authors.initials: J
authors.lastname: Ishiwata
authors.forename: Keiko
authors.initials: K
authors.lastname: Fukino
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Amaki
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Nakamura
mesh_terms: D000368:Aged; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000175:diagnosis*; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000209:etiology*; D057049:Thrombotic Microangiopathies / Q000150:complications* / Q000175:diagnosis*