title: Retinal Sensitivity in Patients with Type I Diabetes without Retinopathy or with Minor Retinal Changes.
abstract: Objective:To evaluate the ability of short-wavelength automated perimetry (SWAP) for the detection of visual impairment in patients with type I diabetes without retinopathy or with minor retinal vascular changes.Design:Comparative cross-sectional study.Participants:30 eyes of 30 healthy subjects and 73 eyes of 73 patients with type I diabetes mellitus were studied.Methods:Ophthalmic examination of diabetic patients showed no retinopathy or minimal changes (less than 5 microaneurisms in each eye) with no previous laser treatment. All patients were examined by means of the SWAP 24-2 strategy. Mean Deviation (MD) and Pattern Standard Deviation (PSD) were compared between both groups.Results:There were differences in the clusters of altered points between both groups (p=0.004). SWAP MD was lower in the diabetic group than in the controls (-2.89 dB vs. -0.20 dB, p<0.001). SWAP PSD also differed between both groups (2.50 dB in control group, 3.12 dB in the diabetic group, p=0.003). In the diabetic group, mean period from the onset of diabetes was 12.6±6.7 years and minimal vascular changes were observed in the retina of 18 eyes (24.7%), while 55 had no lesions (75.3%). No differences in SWAP changes were found between patients without and with minimal diabetic retinopathy.Conclusions:Retinal sensitivity assessed by SWAP is depressed in patients with type I diabetes regardless of the presence of retinal vascular changes.
authors.affiliation: Department of Ophthalmology, Lozano Blesa University Hospital, Zaragoza, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Pinilla
authors.affiliation: Aragon Institute for Health Research, Zaragoza, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Sanchez-Cano
authors.affiliation: Department of Surgery, Gynecology and Obstetrics, University of Zaragoza, Zaragoza, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Ferreras
authors.affiliation: Department of Endocrinology, Miguel Servet University Hospital, Zaragoza, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Acha
authors.affiliation: Department of Ophthalmology, Lozano Blesa University Hospital, Zaragoza, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Pérez-García
authors.affiliation: Department of Ophthalmology, Lozano Blesa University Hospital, Zaragoza, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Ibañez-Alperte
authors.affiliation: Department of Surgery, Gynecology and Obstetrics, University of Zaragoza, Zaragoza, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Abecia
mesh_terms: D000293:Adolescent; D000328:Adult; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000175:diagnosis*; D003930:Diabetic Retinopathy / Q000150:complications / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D000071071:Microaneurysm / Q000150:complications / Q000175:diagnosis* / Q000209:etiology; D014786:Vision Disorders / Q000175:diagnosis* / Q000209:etiology; D058609:Visual Field Tests / Q000379:methods / Q000592:standards*; D055815:Young Adult