title: Use of Direct Oral Anticoagulants in Special Populations.
abstract: Direct oral anticoagulants (DOACs) have been approved for the treatment of venous thromboembolism and atrial fibrillation based on randomized controlled trials (RCTs) of direct comparisons with vitamin K antagonists. Despite having more than 100,000 patients enrolled, safety and efficacy are debated in selected populations. Although DOACs are reviewed as a class of anticoagulant, pharmacokinetic differences exist such that different medications may be beneficial in distinct clinical settings. Synthesizing available evidence based on phase III RCTs, post hoc subgroup analyses, and pooled metaanalyses, this review provides an overview of DOACs and scrutinizes individual differences in their applications for the special populations.
authors.affiliation: Division of Hematology, Department of Medicine, University of Washington Medical Center, University of Washington School of Medicine, 1959 NE Pacific St, Seattle, WA 98195, USA. Electronic address: ali2015@uw.edu.
authors.forename: Ang
authors.initials: A
authors.lastname: Li
authors.affiliation: Division of Cardiology, Department of Medicine, Duke University Medical Center, Box 3850, 2400 Pratt Street, Room 0311, Terrace Level, Durham, NC 27705, USA.
authors.forename: Renato D
authors.initials: RD
authors.lastname: Lopes
authors.affiliation: Division of Hematology, Department of Medicine, University of Washington Medical Center, University of Washington School of Medicine, 1705 Northeast Pacific Street, Box 357710, Seattle, WA 98195, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Garcia
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000097:blood / Q000188:drug therapy*; D017326:Clinical Trials, Phase III as Topic; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D054556:Venous Thromboembolism / Q000097:blood / Q000188:drug therapy*; D014812:Vitamin K / Q000037:antagonists & inhibitors*
chemical_list: D000925:Anticoagulants; D014812:Vitamin K
keywords: Anticoagulation; Atrial fibrillation; DOAC; Venous thromboembolism