title: Osteogenic Sarcoma: A 21st Century Review.
abstract: Compared to other bone tumors, bone osteogenic sarcoma (BOS) continues to confer a much grimmer prognosis as the survival benefit of traditional chemotherapy treatment regimens is still unsatisfactory. Chemotherapy was demonstrated to be effective in eradicating both primary tumor and pulmonary metastases in the last century, with effective agents used in various combination regimens having changed the survival rate from less than 10% to 75%. The most common primary bone cancer, BOS is conventionally a primary intramedullary high-grade malignant tumor characterized by malignant cells forming immature bone or osteoid. BOS is a disease with diverse morphological presentations. The treatment of all morphological variants seem to have been the same for over 30 years. The introduction of antiproliferative agents such as insulin growth factor-binding protein 3 hold promise of a potentially veritable therapeutic target. In this review, we highlight recent data on osteosarcoma to consolidate a platform able to connect bench and bedside.
authors.affiliation: Department of Orthopedics, TianYou Hospital, Wuhan University of Science and Technology, Wuhan, Hubei, P.R. China Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada.
authors.forename: Stephen
authors.initials: S
authors.lastname: Osasan
authors.affiliation: Department of Orthopedics, TianYou Hospital, Wuhan University of Science and Technology, Wuhan, Hubei, P.R. China.
authors.forename: Mingyong
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada.
authors.forename: Fan
authors.initials: F
authors.lastname: Shen
authors.affiliation: Department of Orthopedics, University of Alberta, Edmonton, AB, Canada.
authors.forename: Paulose J
authors.initials: PJ
authors.lastname: Paul
authors.affiliation: Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.
authors.forename: Sujata
authors.initials: S
authors.lastname: Persad
authors.affiliation: Department of Orthopedics, TianYou Hospital, Wuhan University of Science and Technology, Wuhan, Hubei, P.R. China Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada Stollery Children's Hospital, University of Alberta Hospital, Edmonton, AB, Canada sergi@ualberta.ca.
authors.forename: Consolato
authors.initials: C
authors.lastname: Sergi
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017209:Apoptosis; D001343:Autophagy; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D001842:Bone and Bones / Q000378:metabolism; D002453:Cell Cycle; D002467:Cell Nucleus / Q000378:metabolism; D049109:Cell Proliferation; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D012516:Osteosarcoma / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; C515497:IGFBP3 protein, human; D018972:Insulin-Like Growth Factor Binding Protein 3; D036341:Intercellular Signaling Peptides and Proteins
keywords: Bone; growth factors; insulin growth factor binding protein-3; osteosarcoma; pathology; review