title: Management of Biologic Therapy in Moderate to Severe Psoriasis in Surgical Patients: Data From the Spanish Biobadaderm Registry.
abstract: OBJECTIVE
  We now have considerable experience in the use of biologic agents to treat psoriasis, but doubts about management arise in certain clinical settings. Surgery is one of them. Although treatment guidelines advise that biologics be suspended before major surgery, data about actual clinical practices and associated complications are lacking. We aimed to analyze current practice in the clinical management of these cases.
  
  
  METHODS
  Retrospective study of cases in the Biobadaderm database. We analyzed the management of biologic therapy in patients with psoriasis who underwent surgical procedures.
  
  
  RESULTS
  Forty-eight of the 2113 patients registered in Biobadaderm underwent surgery. The largest percentage of procedures (31%) involved skin lesions. Biologic treatment was interrupted in 42% of the cases. No postsurgical complications were significantly related to treatment interruption. Likewise we detected no associations between treatment interruption and other variables, such as sex, age, or duration or severity of psoriasis.
  
  
  CONCLUSIONS
  Continuity of biologic treatment and the risk of postsurgical complications were not associated in this study, although conclusions are limited by the small sample size.
authors.affiliation: Servicio de Dermatología, Hospital Infanta Leonor, Madrid, España. Electronic address: yayogaliano@hotmail.com.
authors.forename: S
authors.initials: S
authors.lastname: Galiano Mejías
authors.affiliation: Servicio de Dermatología, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, España.
authors.forename: G
authors.initials: G
authors.lastname: Carretero
authors.affiliation: Servicio de Dermatología, Hospital Universitario Germans Trias i Pujol, Badalona, Universitat Autónoma de Barcelona, Barcelona, España.
authors.forename: C
authors.initials: C
authors.lastname: Ferrandiz
authors.affiliation: Servicio de Dermatología, Hospital Universitario 12 de Octubre, Madrid, España.
authors.forename: F
authors.initials: F
authors.lastname: Vanaclocha
authors.affiliation: Servicio de Dermatología, Hospital Universitario La Princesa, Madrid, España.
authors.forename: E
authors.initials: E
authors.lastname: Daudén
authors.affiliation: Servicio de Dermatología, Hospital Universitario Reina Sofía, Córdoba, España.
authors.forename: F J
authors.initials: FJ
authors.lastname: Gómez-García
authors.affiliation: Servicio de Dermatología, Hospital Universitario Virgen de la Victoria, Málaga, España.
authors.forename: E
authors.initials: E
authors.lastname: Herrera-Ceballos
authors.affiliation: Servicio de Dermatología, Hospital General Universitario de Alicante, Alicante, España.
authors.forename: I
authors.initials: I
authors.lastname: Belinchón-Romero
authors.affiliation: Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, España.
authors.forename: J L
authors.initials: JL
authors.lastname: Sánchez-Carazo
authors.affiliation: Servicio de Dermatología, Hospital Universitario Fundación Alcorcón, Madrid, España.
authors.forename: J L
authors.initials: JL
authors.lastname: López-Estebaranz
authors.affiliation: Servicio de Dermatología, Hospital Universitario Clinic de Barcelona, Barcelona, España.
authors.forename: M
authors.initials: M
authors.lastname: Alsina
authors.affiliation: Servicio de Dermatología, Hospital del Mar, Parc de Salut Mar, Barcelona, España.
authors.forename: M
authors.initials: M
authors.lastname: Ferrán
authors.affiliation: Servicio de Dermatología, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, España.
authors.forename: R
authors.initials: R
authors.lastname: Torrado
authors.affiliation: Servicio de Dermatología, Hospital Universitario Germans Trias i Pujol, Badalona, Universitat Autónoma de Barcelona, Barcelona, España.
authors.forename: J M
authors.initials: JM
authors.lastname: Carrascosa
authors.affiliation: Servicio de Dermatología, Hospital Universitario 12 de Octubre, Madrid, España.
authors.forename: R
authors.initials: R
authors.lastname: Rivera
authors.affiliation: Servicio de Dermatología, Hospital Universitario La Princesa, Madrid, España.
authors.forename: M
authors.initials: M
authors.lastname: Llamas-Velasco
authors.affiliation: Servicio de Dermatología, Hospital Universitario Reina Sofía, Córdoba, España.
authors.forename: R
authors.initials: R
authors.lastname: Jiménez-Puya
authors.affiliation: Servicio de Dermatología, Hospital Universitario Virgen de la Victoria, Málaga, España.
authors.forename: Mª V
authors.initials: MV
authors.lastname: Mendiola
authors.affiliation: Servicio de Dermatología, Hospital Universitario Fundación Alcorcón, Madrid, España.
authors.forename: D
authors.initials: D
authors.lastname: Ruiz-Genao
authors.affiliation: Unidad de Investigación, Fundación Academia Española de Dermatología y Venereología, Madrid, España.
authors.forename: M A
authors.initials: MA
authors.lastname: Descalzo
authors.affiliation: Servicio de Dermatología, Hospital Infanta Leonor, Madrid, España.
authors.forename: P
authors.initials: P
authors.lastname: de la Cueva Dobao
mesh_terms: D000328:Adult; D000368:Aged; D000758:Anesthesia / Q000379:methods; D019072:Antibiotic Prophylaxis; D018501:Antirheumatic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001685:Biological Factors / Q000008:administration & dosage* / Q000009:adverse effects; D000075203:Contraindications, Drug; D017558:Elective Surgical Procedures; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000139:chemically induced / Q000517:prevention & control*; D011300:Preoperative Care; D011565:Psoriasis / Q000150:complications / Q000188:drug therapy*; D012042:Registries; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology; D013514:Surgical Procedures, Operative; D016896:Treatment Outcome
chemical_list: D018501:Antirheumatic Agents; D001685:Biological Factors; D007166:Immunosuppressive Agents
keywords: Biologic agents; Biológicos; Cirugía; Interrupción; Psoriasis; Surgery; Systemic therapy; Terapia sistémica; Treatment interruption