title: Roles of immune microenvironment heterogeneity in therapy-associated biomarkers in lung cancer.
abstract: Lung cancer development is a complex and dynamic progression with cancer cell mutations itself and its' orchestrate with the tumor microenvironment. Targeted therapies have been stated to heterogeneous lung cancer mutations while have a modest consequence. The tumor immune microenvironment influences lung cancer outcome by balancing the suppressive versus cytotoxic responses. The immune microenvironment heterogeneity may play an important role in lung cancer heterogeneity. In this review, we summarized the immune cells, its related cytokines and partial immune genes diversity in tumor microenvironment and its targeted potential mono and combined therapies. It will help us to make better understand the lung cancer heterogeneity and mechanisms of the drug resistance to find a way out.
authors.affiliation: Zhongshan Hospital Institute of Clinical Science, Fudan University, Shanghai Institute of Clinical Bioinformatics, Biomedical Research Center, Shanghai, China.
authors.forename: Lingyan
authors.initials: L
authors.lastname: Wang
authors.affiliation: Zhongshan Hospital Institute of Clinical Science, Fudan University, Shanghai Institute of Clinical Bioinformatics, Biomedical Research Center, Shanghai, China.
authors.forename: Bijun
authors.initials: B
authors.lastname: Zhu
authors.affiliation: Zhongshan Hospital Institute of Clinical Science, Fudan University, Shanghai Institute of Clinical Bioinformatics, Biomedical Research Center, Shanghai, China.
authors.forename: Miaomiao
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Zhongshan Hospital Institute of Clinical Science, Fudan University, Shanghai Institute of Clinical Bioinformatics, Biomedical Research Center, Shanghai, China. Electronic address: xiangdong.wang@clintransmed.org.
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Wang
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology* / Q000628:therapy*; D008954:Models, Biological; D015398:Signal Transduction; D059016:Tumor Microenvironment / Q000276:immunology*
chemical_list: D014408:Biomarkers, Tumor
keywords: Immune heterogeneity; Immune-targeted therapy; Lung cancer; Tumor microenvironment