title: Self-Reported Sitting Time, Physical Activity and Fibrinolytic and Other Novel Cardio-Metabolic Biomarkers in Active Swedish Seniors.
abstract: BACKGROUND
  Too much sitting is linked with an increased risk of cardiovascular disease and mortality. The mediating mechanisms for these associations are largely unknown, however dysregulated fibrinolysis have emerged as a possible contributor.
  
  
  OBJECTIVE
  We examined the associations of self-reported overall sitting time and physical activity with fibrinolytic and other novel cardio-metabolic biomarkers in older adults.
  
  
  METHODS
  Data was analysed for 364 participants (74±7 yrs) of the Active Seniors group (retired, living independently in their own homes). Linear regression analyses examined associations of categories of categories of sitting time (≤3, 3-6, >6 hrs/day) and overall physical activity (Low, Moderate and High) with biomarkers in serum or plasma, adjusting for age, gender and smoking (with further adjustment for either overall physical activity or sitting time and BMI in secondary analyses).
  
  
  RESULTS
  Compared to sitting ≤ 3 hrs/day, sitting >6 hrs/day was associated with higher tissue plasminogen activator (tPA) and tissue plasminogen activator/plasminogen activator inhibitor-1 complex (tPA-PAI-1 complex). These associations were not independent of overall physical activity or BMI. Compared to those in the high physical activity, low physical activity was associated with a higher BMI, high-sensitivity C-reactive protein (hs-CRP) and tPA-PAI-1 complex levels. Only the associations of BMI and hs-CRP were independent of sitting time.
  
  
  CONCLUSIONS
  These findings provide preliminary cross-sectional evidence for the relationships of sitting time with fibrinolytic markers in older adults. They also reinforce the importance of regular physical activity for cardio-metabolic health.
authors.affiliation: Baker IDI Heart and Diabetes Institute, Melbourne, Australia.|School of Public Health & Preventive Medicine, Monash University, Melbourne, Australia.
authors.forename: Bethany J
authors.initials: BJ
authors.lastname: Howard
authors.affiliation: Faculty of Medicine and Health, School of Health Sciences, Örebro University, Örebro, Sweden.
authors.forename: Anita
authors.initials: A
authors.lastname: Hurtig-Wennlöf
authors.affiliation: Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
authors.forename: Lovisa A
authors.initials: LA
authors.lastname: Olsson
authors.affiliation: Department of Medical Biosciences/Clinical Chemistry, Umeå University, Umeå, Sweden.
authors.forename: Torbjörn K
authors.initials: TK
authors.lastname: Nilsson
authors.affiliation: Baker IDI Heart and Diabetes Institute, Melbourne, Australia.|School of Public Health & Preventive Medicine, Monash University, Melbourne, Australia.|Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.|School of Exercise and Nutrition Sciences, Deakin University, Melbourne, Australia.|School of Sports Science, Exercise and Health, The University of Western Australia, Perth, Australia.|School of Population Health, The University of Queensland, Brisbane, Australia.
authors.forename: David W
authors.initials: DW
authors.lastname: Dunstan
authors.affiliation: Public Health and Clinical Medicine, Family Medicine, Umeå University, Umeå, Sweden.
authors.forename: Patrik
authors.initials: P
authors.lastname: Wennberg