title: Genome-wide analyses of HTLV-1aD strains from Cape Verde, Africa.
abstract: We characterised and reported the first full-length genomes of Human T-cell Lymphotropic Virus Type 1 subgroup HTLV-1aD (CV21 and CV79). This subgroup is one of the major determinants of HTLV-1 infections in North and West Africa, and recombinant strains involving this subgroup have been recently demonstrated. The CV21 and CV79 strains from Cape Verde/Africa were characterised as pure HTLV-1aD genomes, comparative analyses including HTLV-1 subtypes and subgroups revealed HTLV-1aD signatures in the envelope, pol, and pX regions. These genomes provide original information that will contribute to further studies on HTLV-1a epidemiology and evolution.
authors.affiliation: Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Genética Molecular de Microrganismos, Rio de Janeiro, RJ, Brasil.
authors.forename: Louise
authors.initials: L
authors.lastname: Zanella
authors.affiliation: Universidade de Cabo Verde, Departamento de Ciência e Tecnologia, Praia, Santiago, Cabo Verde.
authors.forename: Isabel de
authors.initials: Id
authors.lastname: Pina-Araujo I
authors.affiliation: Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de AIDS e Imunologia Molecular, Rio de Janeiro, RJ, Brasil.
authors.forename: Mariza G
authors.initials: MG
authors.lastname: Morgado
authors.affiliation: Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Genética Molecular de Microrganismos, Rio de Janeiro, RJ, Brasil.
authors.forename: Ana Carolina
authors.initials: AC
authors.lastname: Vicente
mesh_terms: D055726:Cabo Verde; D055106:Genome-Wide Association Study; D015368:Human T-lymphotropic virus 1 / Q000235:genetics*; D006801:Humans; D010802:Phylogeny