title: Prevention and Treatment of Cancer: Hypes and Hopes 6th International Translational Cancer Research Conference.
abstract: Cancer is primarily an "old-age" disease that has an "age-old" history. The overall incidence of cancer is much higher in Western countries, but is rapidly growing in Eastern countries perhaps due to change in life-style. Almost three million studies published to date indicate that cancer is a hyperproliferative disorder that arises from dysregulation of multiple cell signaling pathways. The cancer genome landscape indicates that approximately 140 genes and 12 cell signaling pathways drive almost all cancers. "Targeted therapy," a buzz word in cancer treatment for the past two decades, has provided antibodies, as well as small-molecule inhibitors. These therapies have been successful only in few instances. However, in most cases, minor increase in overall survival has been reported at the cost of huge expense. An alternative strategy is to prevent cancer or to diagnose and treat the disease at an early stage to gain survival benefits. Such interventions are also cost-effective. To address some of these issues, the 6th International Translational Cancer Research Conference was held during February 4-7th, 2016, in Ahmedabad, Gujarat, India; the homeland of Mahatma Gandhi. This conference was focused on utilizing multidisciplinary approaches for prevention and early treatment that would likely simultaneously or sequentially target many key pathways. Several distinguished speakers were invited from around the world. This article highlights primary features of this conference.
authors.affiliation: Department of Cancer Biology, The Gujarat Cancer & Research Institute, New Civil Hospital Campus, Asarwa, Ahmedabad, India prabhudas_p@hotmail.com.
authors.forename: Prabhudas
authors.initials: P
authors.lastname: Patel
authors.affiliation: Department of Cancer Biology, The Gujarat Cancer & Research Institute, New Civil Hospital Campus, Asarwa, Ahmedabad, India.
authors.forename: Hemangini
authors.initials: H
authors.lastname: Vora
authors.affiliation: The University of Texas, M.D. Anderson Cancer Center, Houston, TX, U.S.A.
authors.forename: Bharat B
authors.initials: BB
authors.lastname: Aggarwal
authors.affiliation: The University of Texas, M.D. Anderson Cancer Center, Houston, TX, U.S.A.
authors.forename: Varsha
authors.initials: V
authors.lastname: Gandhi
authors.affiliation: The University of Texas, M.D. Anderson Cancer Center, Houston, TX, U.S.A.
authors.forename: Kapil
authors.initials: K
authors.lastname: Mehta
authors.affiliation: The University of Texas, M.D. Anderson Cancer Center, Houston, TX, U.S.A.
authors.forename: Sen
authors.initials: S
authors.lastname: Pathak
mesh_terms: D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D057170:Translational Research, Biomedical
keywords: Translational cancer research; conference; prevention; therapeutics