title: Anti-troponin antibodies following myocardial infarction.
abstract: Recent improvements in medical and surgical coronary revascularization techniques have significantly improved outcomes for patients with acute myocardial infarction (MI). However, large infarctions are often followed by a poorly understood process of pathological ventricular remodelling, which fails to return the heart to its premorbid state. Although it remains incompletely understood, there is increasing interest in the role of the immune system in this process. One hypothesis is that released cardiac proteins become the focus of an immune response that results in the formation of functionally significant autoantibodies. This review summarizes the current literature, both human and animal, relating to the formation and clinical relevance of anti-troponin antibodies (ATAs) in patients with MI.
authors.affiliation: Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, Queensland 4811, Australia; College of Medicine and Dentistry, James Cook University, Townsville, Queensland 4811, Australia; Department of Cardiology, The Townsville Hospital and Health Service, Townsville, Queensland 4811, Australia. Electronic address: Thomas.O'Donohoe@health.qld.gov.au.
authors.forename: Tom J
authors.initials: TJ
authors.lastname: O'Donohoe
authors.affiliation: Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, Queensland 4811, Australia; College of Medicine and Dentistry, James Cook University, Townsville, Queensland 4811, Australia; College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Queensland 4811, Australia.
authors.forename: Natkunam
authors.initials: N
authors.lastname: Ketheesan
authors.affiliation: College of Medicine and Dentistry, James Cook University, Townsville, Queensland 4811, Australia; Department of Cardiology, The Townsville Hospital and Health Service, Townsville, Queensland 4811, Australia.
authors.forename: Ryan G
authors.initials: RG
authors.lastname: Schrale
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000276:immunology*; D014336:Troponin / Q000276:immunology*; D020257:Ventricular Remodeling / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D014336:Troponin
keywords: Anti-troponin antibodies; Autoantibody; Autoimmunity; Ischaemic heart disease; Myocardial infarction