title: Differential Impact of Hyperglycemia in Critically Ill Patients: Significance in Acute Myocardial Infarction but Not in Sepsis?
abstract: Hyperglycemia is a common condition in critically ill patients admitted to an intensive care unit (ICU). These patients represent an inhomogeneous collective and hyperglycemia might need different evaluation depending on the underlying disorder. To elucidate this, we investigated and compared associations of severe hyperglycemia (>200 mg/dL) and mortality in patients admitted to an ICU for acute myocardial infarction (AMI) or sepsis as the two most frequent admission diagnoses. From 2006 to 2009, 2551 patients 69 (58-77) years; 1544 male; 337 patients suffering from type 2 diabetes (T2DM)) who were admitted because of either AMI or sepsis to an ICU in a tertiary care hospital were investigated retrospectively. Follow-up of patients was performed between May 2013 and November 2013. In a Cox regression analysis, maximum glucose concentration at the day of admission was associated with mortality in the overall cohort (HR = 1.006, 95% CI: 1.004-1.009;p< 0.001) and in patients suffering from myocardial infarction (HR = 1.101, 95% CI: 1.075-1.127;p< 0.001) but only in trend in patients admitted to an ICU for sepsis (HR = 1.030, 95% CI: 0.998-1.062;p= 0.07). Severe hyperglycemia was associated with adverse intra-ICU mortality in the overall cohort (23% vs. 13%;p< 0.001) and patients admitted for AMI (15% vs. 5%;p< 0.001) but not for septic patients (39% vs. 40%;p= 0.48). A medical history of type 2 diabetes (n= 337; 13%) was not associated with increased intra-ICU mortality (15% vs. 15%;p= 0.93) but in patients with severe hyperglycemia and/or a known medical history of type 2 diabetes considered in combination, an increased mortality in AMI patients (intra-ICU 5% vs. 13%;p< 0.001) but not in septic patients (intra-ICU 38% vs. 41%;p= 0.53) could be evidenced. The presence of hyperglycemia in critically ill patients has differential impact within the different etiological groups. Hyperglycemia in AMI patients might identify a sicker patient collective suffering from pre-diabetes or undiagnosed diabetes with its' known adverse consequences, especially in the long-term. Hyperglycemia in sepsis might be considered as adaptive survival mechanism to hypo-perfusion and consecutive lack of glucose in peripheral cells. AMI patients with hyperglycemic derailment during an ICU-stay should be closely followed-up and extensively screened for diabetes to improve patients' outcome.
authors.affiliation: Clinic of Internal Medicine II, Department of Cardiology, Paracelsus Medical University of Salzburg, Salzburg A-5020, Austria. b.wernly@salk.at.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Wernly
authors.affiliation: Clinic of Internal Medicine II, Department of Cardiology, Paracelsus Medical University of Salzburg, Salzburg A-5020, Austria. m.lichtenauer@salk.at.
authors.forename: Michael
authors.initials: M
authors.lastname: Lichtenauer
authors.affiliation: Clinic of Internal Medicine I, Department of Cardiology, Jena University Hospital, Thuringia 07743, Germany. marcus.franz@med.uni-jena.de.
authors.forename: Marcus
authors.initials: M
authors.lastname: Franz
authors.affiliation: Clinic of Internal Medicine I, Department of Cardiology, Jena University Hospital, Thuringia 07743, Germany. bjoern.kabisch@med.uni-jena.de.
authors.forename: Bjoern
authors.initials: B
authors.lastname: Kabisch
authors.affiliation: Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, Düsseldorf 40225, Germany. johanna.muessig@med.uni-duesseldorf.de.
authors.forename: Johanna
authors.initials: J
authors.lastname: Muessig
authors.affiliation: Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, Düsseldorf 40225, Germany. maryna.masyuk@med.uni-duesseldorf.de.
authors.forename: Maryna
authors.initials: M
authors.lastname: Masyuk
authors.affiliation: Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, Düsseldorf 40225, Germany. malte.kelm@med.uni-duesseldorf.de.
authors.forename: Malte
authors.initials: M
authors.lastname: Kelm
authors.affiliation: Clinic of Internal Medicine II, Department of Cardiology, Paracelsus Medical University of Salzburg, Salzburg A-5020, Austria. u.hoppe@salk.at.
authors.forename: Uta C
authors.initials: UC
authors.lastname: Hoppe
authors.affiliation: Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, Düsseldorf 40225, Germany. christian.jung@med.uni-duesseldorf.de.
authors.forename: Christian
authors.initials: C
authors.lastname: Jung
keywords: critically ill; diabetes; hyperglycemia; myocardial infarction; prediabetes; sepsis; stress hyperglycemia