title: CA153 in Breast Secretions as a Potential Molecular Marker for Diagnosing Breast Cancer: A Meta Analysis.
abstract: OBJECTIVE
  Many studies have reported that carbohydrate antigen 153 (CA153) in breast secretions (BS) can discriminate breast cancer (BC) patients from healthy individuals, indicating CA153 in BS as a potential index for BC. This meta-analysis aimed to evaluate the actual diagnostic value of CA153 in BS.
  
  
  METHODS
  Related papers were obtained from Pubmed, Embase, Scopus, Ovid, Sciverse, the Cochrane library, Chinese Biomedical literature Database (CBM), Technology of Chongqing (VIP), Wan Fang Data, and Chinese National Knowledge Infrastructure (CNKI). Pooled sensitivity, specificity, and diagnostic odds ratio (DOR) of CA153 in BS for BC diagnosis were analyzed with the random effect model. SROC and the area under the curve (AUC) were applied to assess overall diagnostic efficiency.
  
  
  RESULTS
  This meta-analysis included five studies with a total of 329 BC patients and 381 healthy subjects. For CA153 in BS, the summary sensitivity, specificity, and DOR to diagnose BC were 0.63 (95% confidence interval (CI): 0.57∼0.68), 0.82 (95% CI: 0.78∼0.86), and 9.18 (95% CI: 4.22∼19.95), respectively. Furthermore, the AUC of BS CA153 in the diagnosis of BC was 0.8614.
  
  
  CONCLUSIONS
  CA153 in BS is a valuable molecular marker in diagnosing BC and should be applied in standard clinical practices of BC screening upon confirmation of our findings in a larger prospective study.
authors.affiliation: Department of Laboratory Medicine, the Third Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi, China.
authors.forename: Shifu
authors.initials: S
authors.lastname: Tang
authors.affiliation: Department of Internal Medicine, the Third Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Wei
authors.affiliation: Department of Laboratory Medicine, the Third Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi, China.
authors.forename: Yifan
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Rheumatology, the Fourth Affiliated Hospital of Guangxi Medical University, Guangxi, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Zhou
authors.affiliation: Department of Laboratory Medicine, the Third Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi, China.
authors.forename: Shengbo
authors.initials: S
authors.lastname: Zhu
authors.affiliation: Department of Laboratory Medicine, the Third Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi, China.
authors.forename: Renqi
authors.initials: R
authors.lastname: Yang
authors.affiliation: Department of Laboratory Medicine, the Third Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi, China.
authors.forename: Yiyong
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Laboratory Medicine, the Third Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi, China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Internal Medicine, the Third Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Xu
authors.affiliation: Department of General Surgery, the Third Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi, China.
authors.forename: Jianqing
authors.initials: J
authors.lastname: Yang
mesh_terms: D000951:Antigens, Neoplasm / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000175:diagnosis*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D012680:Sensitivity and Specificity
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; C000621856:CA153 protein, human