title: Application of Bioactive Compounds from Scutellaria in Neurologic Disorders.
abstract: Inflammation of the brain is one of the most highly researched yet mysterious areas in modern day neurology. The process of inflammation is a normal mechanism of wound healing that can result from acute injuries such as traumas or can be caused by genetic/environmental factors. After the initial insult, the immune system defenses, specifically microglial cells, are activated in order to combat the infection or injury. However, prolonged or chronic inflammation is often deleterious due mainly to accumulation of free reactive oxygen species (ROS) and other pro-inflammatory cytokines in the brain FADDIN EN.CITE. Plant-derived natural compounds have the potential to ameliorate the causes and symptoms of neuroinflammation, due to their various anti-oxidant and anti-inflammatory activities, without completely muting the immune defenses. Scutellaria is a perennial plant in the mint family that has been used to treat diseases in Asia and Eastern Europe throughout history. This chapter reviews the active components of various Scutellaria species and their mechanisms of action to prevent chronic neurologic disorders involving neuroinflammation and neurodegeneration.
authors.affiliation: Department of Neurosurgery, Wayne State University School of Medicine, and Karmanos Cancer Institute, Lande Research Building, #460, 540 E. Canfield St., Detroit, MI, 48201, USA.
authors.forename: Farhan
authors.initials: F
authors.lastname: Hussain
authors.affiliation: Departments of Neurosurgery and Oncology, Wayne State University School of Medicine, and Karmanos Cancer Institute, 930 Harper POB, 4100 John R. St, Detroit, MI, 48201, USA.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Mittal
authors.affiliation: Graduate Program in Biotechnology, Agricultural Research Station, Fort Valley State University, Fort Valley, GA, USA.
authors.forename: Nirmal
authors.initials: N
authors.lastname: Joshee
authors.affiliation: Department of Neurosurgery, Wayne State University School of Medicine, and Karmanos Cancer Institute, Lande Research Building, #460, 540 E. Canfield St., Detroit, MI, 48201, USA. pparajuli@med.wayne.edu.
authors.forename: Prahlad
authors.initials: P
authors.lastname: Parajuli
mesh_terms: D001208:Asia; D005061:Europe, Eastern; D006801:Humans; D017628:Microglia / Q000187:drug effects; D009422:Nervous System Diseases / Q000628:therapy*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D031363:Scutellaria / Q000737:chemistry*
chemical_list: D010936:Plant Extracts
keywords: Flavonoids; Neurodegeneration; Neuroinflammation; Neuroprotection; Scutellaria