title: Severe Coagulation Disorder and Thrombocytopenia Associated with Tigecycline - Case Report and Review of Literature.
abstract: Herein, we report a 70-year-old male patient, with recurrent multiple hepatic abscesses, that was admitted to the internal medicine department for treatment of Carbapenem Resistant Escherichia Coli (CRE) bacteremia. The patient was treated with Tigecycline; few days later, he developed &quot;Disseminated Intravascular Coagulation (DIC)&quot; like coagulation study abnormality that seemed to be related to Tigecycline treatment. Upon discontinuing it, the DIC-like condition was resolved. Tigecycline should be considered as a possible etiological factor in patients with DIC-like, and this therapy should be withdrawn immediately in suspected cases.
authors.forename: Sami
authors.initials: S
authors.lastname: Giryes
authors.forename: Zaher S
authors.initials: ZS
authors.lastname: Azzam
authors.forename: Reem
authors.initials: R
authors.lastname: Ismael-Badarneh
authors.forename: Norberto
authors.initials: N
authors.lastname: Krivoy
authors.affiliation: Department of Internal Medicine "B", Rambam Health Care Campus, P.O. Box 9602, Haifa, 31096;. Israel.
authors.forename: Gidon
authors.initials: G
authors.lastname: Berger
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008911:Minocycline / Q000009:adverse effects / Q000031:analogs & derivatives*; D012720:Severity of Illness Index; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis*; D000078304:Tigecycline
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline
keywords: Coagulation disorder; DIC; Tigecycline; hypofibrinogenemia; thrombocytopenia