title: Multicentric Squamous Odontogenic Tumor: A Case Report and Review of the Literature.
abstract: Squamous odontogenic tumor (SOT) is a rare benign epithelial odontogenic neoplasm of the jaws. Both intraosseous and peripheral SOTs have been described in the English language literature. While most intraosseous SOTs occur as solitary lesions, a multicentric variant has also been previously described. Although the radiographic and microscopic features are identical for both solitary and multicentric clinical presentations, there are three significant differences between them. More specifically, multicentric SOT presents at an earlier age (third decade of life), has a slightly higher male to female ratio than the solitary type and has a marked predilection for African-Americans. Here we document the eighth reported case of multicentric SOT, which was diagnosed in a 43-year-old African-American male. In addition, we feature focal sebaceous metaplasia, a heretofore unknown microscopic feature of SOT. Clinical, radiological, and histopathological findings are discussed. The differential diagnosis, biological behavior and management modalities for SOT are also addressed.
authors.affiliation: Department of Oral Diagnostic Sciences, University at Buffalo, The State University of New York, 355 Squire Hall, Buffalo, 14214, NY, USA.
authors.forename: Sophia
authors.initials: S
authors.lastname: Elmuradi
authors.affiliation: Department of Oral Diagnostic Sciences, University at Buffalo, The State University of New York, 355 Squire Hall, Buffalo, 14214, NY, USA.
authors.forename: Yasmin
authors.initials: Y
authors.lastname: Mair
authors.affiliation: IMMCO Diagnostics, Inc, Buffalo, NY, USA.
authors.forename: Lakshmanan
authors.initials: L
authors.lastname: Suresh
authors.affiliation: Oral and Maxillofacial Surgeon, Private Practice, Johnson City, NY, USA.
authors.forename: James
authors.initials: J
authors.lastname: DeSantis
authors.affiliation: IMMCO Diagnostics, Inc, Buffalo, NY, USA.
authors.forename: Mirdza
authors.initials: M
authors.lastname: Neiders
authors.affiliation: Department of Oral Diagnostic Sciences, University at Buffalo, The State University of New York, 355 Squire Hall, Buffalo, 14214, NY, USA. aguirr@buffalo.edu.
authors.forename: Alfredo
authors.identifier: http://orcid.org/0000-0003-2331-9324
authors.initials: A
authors.lastname: Aguirre
mesh_terms: D000328:Adult; D006801:Humans; D007573:Jaw Neoplasms / Q000473:pathology*; D008297:Male; D008339:Mandibular Neoplasms / Q000473:pathology; D008441:Maxillary Neoplasms / Q000473:pathology; D051527:Odontogenic Tumor, Squamous / Q000473:pathology*
keywords: Multicentric; Odontogenic; Squamous; Tumor