title: Prevention of Infection Due to Clostridium difficile.
abstract: Clostridium difficile is one of the foremost nosocomial pathogens. Preventing infection is particularly challenging. Effective prevention efforts typically require a multifaceted bundled approach. A variety of infection control procedures may be advantageous, including strict hand decontamination with soap and water, contact precautions, and using chlorine-containing decontamination agents. Additionally, risk factor reduction can help reduce the burden of disease. The risk factor modification is principally accomplished though antibiotic stewardship programs. Unfortunately, most of the current evidence for prevention is in acute care settings. This review focuses on preventative approaches to reduce the incidence of Clostridium difficile infection in healthcare settings.
authors.affiliation: Division of Infectious Diseases, Wayne State University, 3990 John R. Street, 5 Hudson, Detroit, MI 48201, USA.
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Cooper
authors.affiliation: Infectious Disease Section, Medical Division, Geriatric Research Education and Clinical Center (GRECC), Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Boulevard, Cleveland, OH 44106, USA; Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
authors.forename: Robin L P
authors.initials: RL
authors.lastname: Jump
authors.affiliation: Division of Infectious Diseases, Wayne State University, 3990 John R. Street, 5 Hudson, Detroit, MI 48201, USA. Electronic address: tchopra@med.wayne.edu.
authors.forename: Teena
authors.initials: T
authors.lastname: Chopra
mesh_terms: D016360:Clostridioides difficile; D003015:Clostridium Infections / Q000517:prevention & control*; D003428:Cross Infection / Q000517:prevention & control*; D006235:Hand Disinfection; D006801:Humans; D017053:Infection Control
keywords: Antibiotic stewardship; Bleach; Clostridium difficile; Contact precautions; Environmental decontamination; Hand washing; Infection control; Prevention