title: Sirtuins in glucose and lipid metabolism.
abstract: Sirtuins are evolutionarily conserved protein, serving as nicotinamide adenine dinucleotide-dependent deacetylases or adenosine diphosphate-ribosyltransferases. The mammalian sirtuins family, including SIRT1~7, is involved in many biological processes such as cell survival, proliferation, senescence, stress response, genome stability and metabolism. Evidence accumulated over the past two decades has indicated that sirtuins not only serve as important energy status sensors but also protect cells against metabolic stresses. In this review, we summarize the background of glucose and lipid metabolism concerning sirtuins and discuss the functions of sirtuins in glucose and lipid metabolism. We also seek to highlight the biological roles of certain sirtuins members in cancer metabolism.
authors.affiliation: Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Ye
authors.affiliation: Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China.
authors.forename: Meiting
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China.
authors.forename: Tianyun
authors.initials: T
authors.lastname: Hou
authors.affiliation: Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China.
authors.forename: Tian
authors.initials: T
authors.lastname: Gao
authors.affiliation: Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China.
authors.forename: Wei-Guo
authors.initials: WG
authors.lastname: Zhu
authors.affiliation: Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D049109:Cell Proliferation / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D016922:Cellular Senescence / Q000502:physiology; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology*; D009243:NAD / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism*; D037761:Sirtuins / Q000378:metabolism*
chemical_list: D009243:NAD; D000244:Adenosine Diphosphate; D037761:Sirtuins; D005947:Glucose
keywords: SIRT1-SIRT7; glucose metabolism; lipid metabolism; regulation; sirtuins