title: The mechanosensor of mesenchymal stem cells: mechanosensitive channel or cytoskeleton?
abstract: Mesenchymal stem cells (MSCs) are multipotent adult stem cells. MSCs and their potential for use in regenerative medicine have been investigated extensively. Recently, the mechanisms by which MSCs detect mechanical stimuli have been described in detail. As in other cell types, both mechanosensitive channels, such as transient receptor potential melastatin 7 (TRPM7), and the cytoskeleton, including actin and actomyosin, have been implicated in mechanosensation in MSCs. This review will focus on discussing the precise role of TRPM7 and the cytoskeleton in mechanosensation in MSCs.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Peking University, School and Hospital of Stomatology; National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of digital Stomatology, 22 Zhongguancun Nandajie, Haidian District, Beijing, 100081, China.
authors.forename: E
authors.initials: E
authors.lastname: Xiao
authors.affiliation: Department of Anatomy and Cell Biology, University of Pennsylvania, School of Dental Medicine, 19104, Philadelphia, Pennsylvania, USA.
authors.forename: Chider
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Oral and Maxillofacial Surgery, Peking University, School and Hospital of Stomatology; National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of digital Stomatology, 22 Zhongguancun Nandajie, Haidian District, Beijing, 100081, China. zhangyi2000@263.net.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000199:Actins / Q000235:genetics / Q000378:metabolism; D000205:Actomyosin / Q000235:genetics / Q000378:metabolism; D000818:Animals; D055396:Bone Morphogenetic Protein 2 / Q000235:genetics / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism* / Q000648:ultrastructure; D005786:Gene Expression Regulation; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D040542:Mechanotransduction, Cellular; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*; D050053:TRPM Cation Channels / Q000235:genetics / Q000378:metabolism*; D016596:Vinculin / Q000235:genetics / Q000378:metabolism
chemical_list: D000199:Actins; C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D050053:TRPM Cation Channels; C488955:VCL protein, human; D016596:Vinculin; D015544:Inositol 1,4,5-Trisphosphate; D000205:Actomyosin; D017346:Protein Serine-Threonine Kinases; C486583:TRPM7 protein, human; D002118:Calcium
keywords: Cytoskeleton; Mechanosensation; Mesenchymal stem cells; TRPM7