title: Vesicular trafficking regulators are new players in breast cancer progression: Role of TOM1L1 in ERBB2-dependent invasion.
abstract: ERBB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2) amplification is associated with invasive breast cancer. We discovered that TOM1L1 (target of myb1-like 1) and ERBB2 co-amplification defines a novel mechanism involved in breast cancer metastatic progression. Upregulation of the vesicular trafficking protein TOM1L1 enhances plasma membrane delivery of membrane-type 1 matrix metalloprotease (MT1-MMP) for efficient extracellular matrix degradation and tumor cell dissemination.
authors.affiliation: Centre de Recherche de Biologie Cellulaire de Montpellier, Equipe labellisée Ligue Contre le Cancer, CNRS UMR 5237 , Montpellier, France.
authors.forename: Clément
authors.initials: C
authors.lastname: Chevalier
authors.affiliation: Centre de Recherche de Biologie Cellulaire de Montpellier, Equipe labellisée Ligue Contre le Cancer, CNRS UMR 5237 , Montpellier, France.
authors.forename: Serge
authors.initials: S
authors.lastname: Roche
authors.affiliation: Centre de Recherche de Biologie Cellulaire de Montpellier, Equipe labellisée Ligue Contre le Cancer, CNRS UMR 5237, Montpellier, France; Centre de Biochimie Structurale, CNRS UMR 5048-INSERM UMR 1054, Montpellier, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Bénistant
keywords: Breast cancer; metastasis; tumor cell signaling; tyrosine kinase; vesicular trafficking