title: Prophylaxis of pancreatitis with intravenous ketoprofen in a consecutive population of ERCP patients: a randomized double-blind placebo-controlled trial.
abstract: Background Acute pancreatitis is the most common complication after ERCP, occurring in about 4 % of the procedures. Only the placement of pancreatic duct prosthesis and the use of nonsteroidal anti-inflammatory drugs (NSAIDs) have shown benefit in the prevention of post-ERCP pancreatitis (PEP). Although the benefit of rectal administration of indomethacin or diclofenac is recommended by some studies and society guidelines especially in a selected group of high-risk patients, there is so far, no standardization of time or route of NSAID administration. The aim of the current study is to investigate the role of an intravenous NSAID administered before the procedure for PEP prevention. Methods In this randomized double-blind clinical trial, all consecutive patients who underwent ERCP were randomized to receive saline infusion with ketoprofen or saline, immediately before the procedure. Results A total of 477 patients were enrolled and completed follow-up. The majority of patients (72.1 %) had bile duct stones, and only 1.5 % had a clinical suspicion of sphincter of Oddi dysfunction. PEP developed in 5 of 253 (2 %) patients in the placebo group and in 5 of 224 (2.2 %) patients in the ketoprofen group (p = 1.). Conclusions Intravenous administration of ketoprofen immediately prior to ERCP did not result in reduction in PEP in a general population of ERCP patients.
authors.affiliation: Department of Gastroenterology and Hepatology, Santa Casa Hospital/Federal University of Health Sciences of Porto Alegre (UFCSPA), Rua São Francisco, 469/1203, Porto Alegre, 90620-070, Brazil. fqonofrio@gmail.com.
authors.forename: Fernanda
authors.identifier: 0000-0003-0847-7543
authors.initials: F
authors.lastname: de Quadros Onófrio
authors.affiliation: Department of Gastroenterology and Hepatology, Santa Casa Hospital/Federal University of Health Sciences of Porto Alegre (UFCSPA), Rua São Francisco, 469/1203, Porto Alegre, 90620-070, Brazil.
authors.forename: Julio Carlos Pereira
authors.initials: JCP
authors.lastname: Lima
authors.affiliation: The Post-Graduation Program in Chest Medicine Sciences, Santa Casa Hospital, Porto Alegre, Brazil.
authors.forename: Guilherme
authors.initials: G
authors.lastname: Watte
authors.affiliation: Department of Anesthesiology, Santa Casa Hospital, Porto Alegre, Brazil.
authors.forename: Romnei Lenon
authors.initials: RL
authors.lastname: Lehmen
authors.affiliation: Department of Gastroenterology and Hepatology, Santa Casa Hospital/Federal University of Health Sciences of Porto Alegre (UFCSPA), Rua São Francisco, 469/1203, Porto Alegre, 90620-070, Brazil.
authors.forename: Daniela
authors.initials: D
authors.lastname: Oba
authors.affiliation: Department of Gastroenterology and Hepatology, Santa Casa Hospital/Federal University of Health Sciences of Porto Alegre (UFCSPA), Rua São Francisco, 469/1203, Porto Alegre, 90620-070, Brazil.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Camargo
authors.affiliation: Department of Gastroenterology and Endoscopy, Santa Casa de Caridade de Bagé, Bagé, Brazil.
authors.forename: Carlos Eduardo Oliveira
authors.initials: CEO
authors.lastname: Dos Santos
mesh_terms: D061605:Administration, Intravenous; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007660:Ketoprofen / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D012307:Risk Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007660:Ketoprofen
keywords: Acute pancreatitis; Anti-inflammatory drug; Endoscopic retrograde cholangiopancreatography