title: Evaluation of the protective effect of thiamine pyrophosphate based on the biochemical analysis of rabbit foetuses at 30 days of gestation.
abstract: This study evaluated the effects of thiamine pyrophosphate (PPT) on the biochemical profiles of full-term rabbit foetuses that were subjected to experimental ischemia followed by 24h reperfusion. A total of 16 gestating rabbit dams were divided into two groups, one of which was treated by administering PPT and subjected to a process ischemia. During this interval, fetal blood samples were drawn from each dam (in the ischemia group) at 0, 15 and 45min. Ischemia for 15 and 45min was not associated with changes in lactate levels of the Ischemia group foetuses. However, in the foetuses in the reperfusion groups without PPT lactate levels were significantly higher after 15 and 45min of arterial occlusion compared to time zero. These results demonstrate that PTT alters some acute and some longer-term biochemical outcomes of uterine ischemia perhaps important in preserving energy metabolism under hypoxic conditions.
authors.affiliation: Ph. D. Program in Biological Sciences and Health, Universidad Autónoma Metropolitana (UAM), Mexico City 04960, Mexico; Experimental Surgery Department, Instituto Nacional de Pediatría (INP), Mexico City 04530, Mexico.
authors.forename: M A
authors.initials: MA
authors.lastname: Jiménez-Bravo
authors.affiliation: Stress Physiology and Farm Animal Welfare, Department of Animal Production and Agriculture, Universidad Autónoma Metropolitana (UAM), Mexico City 04960, Mexico. Electronic address: dmota100@yahoo.com.mx.
authors.forename: D
authors.initials: D
authors.lastname: Mota-Rojas
authors.affiliation: Facultad de Agronomía y Veterinaria, Universidad Autónoma de San Luis Potosí (UASLP), San Luis Potosí 78321, Mexico.
authors.forename: H
authors.initials: H
authors.lastname: Orozco-Gregorio
authors.affiliation: Experimental Surgery Department, Instituto Nacional de Pediatría (INP), Mexico City 04530, Mexico.
authors.forename: B
authors.initials: B
authors.lastname: Pérez-Guille
authors.affiliation: Experimental Surgery Department, Instituto Nacional de Pediatría (INP), Mexico City 04530, Mexico.
authors.forename: R
authors.initials: R
authors.lastname: Soriano-Rosales
authors.affiliation: Stress Physiology and Farm Animal Welfare, Department of Animal Production and Agriculture, Universidad Autónoma Metropolitana (UAM), Mexico City 04960, Mexico.
authors.forename: P
authors.initials: P
authors.lastname: Roldan-Santiago
authors.affiliation: Stress Physiology and Farm Animal Welfare, Department of Animal Production and Agriculture, Universidad Autónoma Metropolitana (UAM), Mexico City 04960, Mexico.
authors.forename: M
authors.initials: M
authors.lastname: Alonso-Spilsbury
authors.affiliation: Bioacoustics Laboratory, Instituto Nacional de Rehabilitación (INR), Mexico City 14389, Mexico.
authors.forename: E
authors.initials: E
authors.lastname: Arch-Tirado
authors.affiliation: Department of Livestock Sciences, FESC., Universidad Nacional Autónoma de México (UNAM), State of Mexico 54714, Mexico.
authors.forename: P
authors.initials: P
authors.lastname: Mora-Medina
authors.affiliation: Postgraduate Division and Research, Veterinary Medicine Faculty, Universidad Autónoma de Tamaulipas, Ciudad Victoria, Tamaulipas, Mexico.
authors.forename: J
authors.initials: J
authors.lastname: Martínez-Burnes
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002118:Calcium / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000187:drug effects* / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D000860:Hypoxia / Q000378:metabolism; D007511:Ischemia / Q000378:metabolism*; D019344:Lactic Acid / Q000097:blood; D020011:Protective Agents / Q000494:pharmacology*; D011817:Rabbits; D013835:Thiamine Pyrophosphate / Q000494:pharmacology*; D014599:Uterus / Q000098:blood supply*
chemical_list: D001786:Blood Glucose; D020011:Protective Agents; D019344:Lactic Acid; D013835:Thiamine Pyrophosphate; D002118:Calcium
keywords: Cocarboxylase; Foetal welfare; Foetuses; Hypoxic-encephalopathy; Protective effect; Thiamine pyrophosphate