title: Chemical constituents from Cordia alliodora and C. colloccoca (Boraginaceae) and their biological activities.
abstract: Two new natural products, 5-O-[β-D-apiofuranosyl-(1→6)-β-d-glucopyranosyl]-1-isoindolinone (1) as well as N-(2E)-3-[(2S,3R)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-2,3-dihydro-1-benzofuran-5-yl]acryloylglycine (2), along with four known compounds (3-6), were isolated from the methanolic extract of Cordia alliodora root bark. Furthermore, the methanolic extract of Cordia colloccoca leaves, afforded the known flavonoids afzelin (7) and quercitrin (8). The isolated secondary metabolites were assayed for their antimicrobial activities against a panel of 6g positive and negative bacteria and three human pathogenic fungi. Moreover, their antiproliferative effect was also evaluated in vitro against the human non-small-cell bronchopulmonary carcinoma line NSCLC-N6, the epidermoid lung cancer cell line A549 as well as the normal human skin fibroblast cell line (AG01523).
authors.affiliation: Division of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, University of Athens, 15471 Athens, Greece.
authors.forename: Myrto Maria
authors.initials: MM
authors.lastname: Fouseki
authors.affiliation: Division of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, University of Athens, 15471 Athens, Greece.
authors.forename: Harilaos
authors.initials: H
authors.lastname: Damianakos
authors.affiliation: Department of Medical Laboratories Technology, Technological and Educational Institute of Athens, 12243 Athens, Greece.
authors.forename: George Albert
authors.initials: GA
authors.lastname: Karikas
authors.affiliation: Faculty of Pharmaceutical and Biological Science, LUNAM University, University of Nantes, IICIMED/ERATU-EA 1155, 1 Rue Gaston Veil, BP 53508, Nantes Cedex 01, France.
authors.forename: Christos
authors.initials: C
authors.lastname: Roussakis
authors.affiliation: Center for Pharmacognostic Research on Panamanian Flora (CIFLOPAN), University of Panama, 10767 Panama City, Republic of Panama.
authors.forename: Mahabir
authors.initials: M
authors.lastname: P Gupta
authors.affiliation: Division of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, University of Athens, 15471 Athens, Greece. Electronic address: ichinou@pharm.uoa.gr.
authors.forename: Ioanna
authors.initials: I
authors.lastname: Chinou
mesh_terms: D001419:Bacteria / Q000187:drug effects; D045744:Cell Line, Tumor; D031213:Cordia / Q000737:chemistry* / Q000145:classification; D005347:Fibroblasts / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000302:isolation & purification; D008362:Mannosides / Q000737:chemistry / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D044945:Proanthocyanidins / Q000737:chemistry / Q000302:isolation & purification; D011794:Quercetin / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D007211:Indoles; D008362:Mannosides; D010936:Plant Extracts; D044945:Proanthocyanidins; C012526:quercitrin; C477954:afzelin; D011794:Quercetin
keywords: Boraginaceae; Cordia alliodora; Cordia colloccoca; Flavonoid; Isoindoline alkaloid; Lignanamide