title: Lifetime risk of diabetes among First Nations and non-First Nations people.
abstract: BACKGROUND
  Lifetime risk is a relatively straightforward measure used to communicate disease burden, representing the cumulative risk of an outcome during the remainder of an individual's life starting from a disease-free index age. We estimated the lifetime risk of diabetes among men and women in both First Nations and non-First Nations populations using a cohort of adults in a single Canadian province.
  
  
  METHODS
  We used a population-based cohort consisting of Alberta residents from 1997 to 2008 who were free of diabetes at cohort entry to estimate the lifetime risk of diabetes among First Nations and non-First Nations people. We calculated age-specific incidence rates with the person-year method in 5-year bands. We estimated the sex- and index-age-specific lifetime risk of incident diabetes, after adjusting for the competing risk of death.
  
  
  RESULTS
  The cohort included 70 631 First Nations and 2 732 214 non-First Nations people aged 18 years or older. The lifetime risk of diabetes at 20 years of age was 75.6% among men and 87.3% among women in the First Nations group, as compared with 55.6% among men and 46.5% among women in the non-First Nations group. The risk was higher among First Nations people than among non-First Nations people for all index ages and for both sexes. Among non-First Nations people, men had a higher lifetime risk of diabetes than women across all index ages. In contrast, among First Nations people, women had a higher lifetime risk than men across all index ages.
  
  
  CONCLUSIONS
  About 8 in 10 First Nations people and about 5 in 10 non-First Nations people of young age will develop diabetes in their remaining lifetime. These population-based estimates may help health care planners and decision-makers set priorities and increase public awareness and interest in the prevention of diabetes.
authors.affiliation: Department of Family Medicine (Turin), Department of Community Health Sciences (Turin, Manns, Hemmelgarn), Institute of Public Health (Turin, Manns, Hemmelgarn) and Department of Medicine (Saad, Jun, Tonelli, Ma, Barnabe, Manns, Hemmelgarn), University of Calgary, Calgary, Alta. turin.chowdhury@ucalgary.ca.
authors.forename: Tanvir Chowdhury
authors.initials: TC
authors.lastname: Turin
authors.affiliation: Department of Family Medicine (Turin), Department of Community Health Sciences (Turin, Manns, Hemmelgarn), Institute of Public Health (Turin, Manns, Hemmelgarn) and Department of Medicine (Saad, Jun, Tonelli, Ma, Barnabe, Manns, Hemmelgarn), University of Calgary, Calgary, Alta.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Saad
authors.affiliation: Department of Family Medicine (Turin), Department of Community Health Sciences (Turin, Manns, Hemmelgarn), Institute of Public Health (Turin, Manns, Hemmelgarn) and Department of Medicine (Saad, Jun, Tonelli, Ma, Barnabe, Manns, Hemmelgarn), University of Calgary, Calgary, Alta.
authors.forename: Min
authors.initials: M
authors.lastname: Jun
authors.affiliation: Department of Family Medicine (Turin), Department of Community Health Sciences (Turin, Manns, Hemmelgarn), Institute of Public Health (Turin, Manns, Hemmelgarn) and Department of Medicine (Saad, Jun, Tonelli, Ma, Barnabe, Manns, Hemmelgarn), University of Calgary, Calgary, Alta.
authors.forename: Marcello
authors.initials: M
authors.lastname: Tonelli
authors.affiliation: Department of Family Medicine (Turin), Department of Community Health Sciences (Turin, Manns, Hemmelgarn), Institute of Public Health (Turin, Manns, Hemmelgarn) and Department of Medicine (Saad, Jun, Tonelli, Ma, Barnabe, Manns, Hemmelgarn), University of Calgary, Calgary, Alta.
authors.forename: Zhihai
authors.initials: Z
authors.lastname: Ma
authors.affiliation: Department of Family Medicine (Turin), Department of Community Health Sciences (Turin, Manns, Hemmelgarn), Institute of Public Health (Turin, Manns, Hemmelgarn) and Department of Medicine (Saad, Jun, Tonelli, Ma, Barnabe, Manns, Hemmelgarn), University of Calgary, Calgary, Alta.
authors.forename: Cheryl Carmelle Marie
authors.initials: CCM
authors.lastname: Barnabe
authors.affiliation: Department of Family Medicine (Turin), Department of Community Health Sciences (Turin, Manns, Hemmelgarn), Institute of Public Health (Turin, Manns, Hemmelgarn) and Department of Medicine (Saad, Jun, Tonelli, Ma, Barnabe, Manns, Hemmelgarn), University of Calgary, Calgary, Alta.
authors.forename: Braden
authors.initials: B
authors.lastname: Manns
authors.affiliation: Department of Family Medicine (Turin), Department of Community Health Sciences (Turin, Manns, Hemmelgarn), Institute of Public Health (Turin, Manns, Hemmelgarn) and Department of Medicine (Saad, Jun, Tonelli, Ma, Barnabe, Manns, Hemmelgarn), University of Calgary, Calgary, Alta.
authors.forename: Brenda
authors.initials: B
authors.lastname: Hemmelgarn
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000416:Alberta / Q000453:epidemiology; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000208:ethnology*; D005260:Female; D006801:Humans; D007198:Indians, North American; D008297:Male; D008875:Middle Aged; D012042:Registries; D012307:Risk Factors; D017678:Sex Distribution; D055815:Young Adult