title: Isocyanide-Based Multicomponent Bicyclization with Substituted Allenoate and Isatin: Synthesis of Unusual Spirooxindole Containing [5.5]-Fused Heterocycle.
abstract: A three-component bicyclization reaction of isocyanide, substituted allenoate, and isatin has been disclosed. This protocol is proposed to proceed through Michael addition, double cyclization, and [1,5]-hydride shift sequence, thus leading to the formation of two new rings and five new chemical bonds, including C-C, C-O, and C-N bonds.
authors.affiliation: Department of Chemistry, Innovative Drug Research Center, and ‡Shanghai Key Laboratory of High Temperature Superconductors, Shanghai University , Shanghai 200444, People's Republic of China.
authors.forename: Zhongzhong
authors.initials: Z
authors.lastname: Tang
authors.affiliation: Department of Chemistry, Innovative Drug Research Center, and ‡Shanghai Key Laboratory of High Temperature Superconductors, Shanghai University , Shanghai 200444, People's Republic of China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Chemistry, Innovative Drug Research Center, and ‡Shanghai Key Laboratory of High Temperature Superconductors, Shanghai University , Shanghai 200444, People's Republic of China.
authors.forename: Yu
authors.initials: Y
authors.lastname: An
authors.affiliation: Department of Chemistry, Innovative Drug Research Center, and ‡Shanghai Key Laboratory of High Temperature Superconductors, Shanghai University , Shanghai 200444, People's Republic of China.
authors.forename: Ruolan
authors.initials: R
authors.lastname: Jiang
authors.affiliation: Department of Chemistry, Innovative Drug Research Center, and ‡Shanghai Key Laboratory of High Temperature Superconductors, Shanghai University , Shanghai 200444, People's Republic of China.
authors.forename: Xinglu
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, Innovative Drug Research Center, and ‡Shanghai Key Laboratory of High Temperature Superconductors, Shanghai University , Shanghai 200444, People's Republic of China.
authors.forename: Chunju
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Chemistry, Innovative Drug Research Center, and ‡Shanghai Key Laboratory of High Temperature Superconductors, Shanghai University , Shanghai 200444, People's Republic of China.
authors.forename: Xueshun
authors.initials: X
authors.lastname: Jia
authors.affiliation: Department of Chemistry, Innovative Drug Research Center, and ‡Shanghai Key Laboratory of High Temperature Superconductors, Shanghai University , Shanghai 200444, People's Republic of China.
authors.forename: Jian
authors.initials: J
authors.lastname: Li