title: [A Case of Resected Giant Gastrointestinal Stromal Tumor Associated with Intraperitoneal Bleeding Following Imatinib Administration].
abstract: A 76-year-old woman with tarry stool was referred to our hospital for further examination. Contrast-enhanced computed tomography(CT)revealed a heterogeneous 15 cm tumor located in the left upper abdominal cavity. The tumor had a rich vascularity and was associated with intra-abdominal bleeding. Gastroscopy showed a large submucosal tumor in the gastric body. A biopsy was performed, and the patient was diagnosed with a c-kit-positive gastrointestinal stromal tumor(GIST)of the stomach. Imatinib mesylate(400mg/day)was administered for 6 months. Vascularity in the tumor was diminished and no new lesion had emerged, although there was no remarkable reduction in tumor size. The patient underwent partial gastrectomy and splenectomy with curative intent. She is currently alive 1 year and 4 months after surgery with no evidence of recurrence.
authors.affiliation: Dept. of Gastroenterological Surgery, Hiroshima Prefectural Hospital.
authors.forename: Ryuta
authors.initials: R
authors.lastname: Ide
authors.forename: Takahisa
authors.initials: T
authors.lastname: Suzuki
authors.forename: Yuji
authors.initials: Y
authors.lastname: Takakura
authors.forename: Akihiko
authors.initials: A
authors.lastname: Oshita
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ikeda
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Matsugu
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakahara
authors.forename: Takashi
authors.initials: T
authors.lastname: Urushihara
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Itamoto
authors.forename: Katsunori
authors.initials: K
authors.lastname: Shinozaki
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy* / Q000601:surgery; D005773:Gastroscopy; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D000068877:Imatinib Mesylate / Q000627:therapeutic use*; D020360:Neoadjuvant Therapy; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
chemical_list: D000970:Antineoplastic Agents; D000068877:Imatinib Mesylate