title: Effects of tianeptine on the development and maintenance of mechanical allodynia in a rat model of neuropathic pain.
abstract: We validate the analgesic efficacy of tianeptine by different administration routes and timing in a rat model of neuropathic pain. Neuropathic pain was induced by ligating the L5 and L6 spinal nerves in male Sprague-Dawley rats, and mechanical allodynia was assessed using von Frey filaments. The effects of orally administered tianeptine and pretreatment with tianeptine (intrathecally or intraperitoneally) on mechanical allodynia were assessed. Oral and preemptive intrathecal administration of tianeptine significantly increased the paw withdrawal threshold but preemptive intraperitoneal administration did not. Nevertheless, intraperitoneal pretreatment of tianeptine potentiated the antiallodynic effects of subsequently administered tianeptine. These findings suggest that tianeptine may be effective for preventing and treating neuropathic pain and that it can be used more widely in clinical pain practice.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School, 42 Jebongro, Donggu, Gwangju, 501-757, Republic of Korea.
authors.forename: Bong Ha
authors.initials: BH
authors.lastname: Heo
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School, 42 Jebongro, Donggu, Gwangju, 501-757, Republic of Korea.
authors.forename: Jae Yun
authors.initials: JY
authors.lastname: Shin
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School, 42 Jebongro, Donggu, Gwangju, 501-757, Republic of Korea.
authors.forename: Keun Suk
authors.initials: KS
authors.lastname: Park
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School, 42 Jebongro, Donggu, Gwangju, 501-757, Republic of Korea.
authors.forename: Hyung Gon
authors.initials: HG
authors.lastname: Lee
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School, 42 Jebongro, Donggu, Gwangju, 501-757, Republic of Korea.
authors.forename: Jeong Il
authors.initials: JI
authors.lastname: Choi
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School, 42 Jebongro, Donggu, Gwangju, 501-757, Republic of Korea.
authors.forename: Myung Ha
authors.initials: MH
authors.lastname: Yoon
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School, 42 Jebongro, Donggu, Gwangju, 501-757, Republic of Korea. Electronic address: kimwm@jnu.ac.kr.
authors.forename: Woong Mo
authors.initials: WM
authors.lastname: Kim
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use*; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D006930:Hyperalgesia / Q000188:drug therapy* / Q000503:physiopathology; D008026:Ligation; D008297:Male; D009437:Neuralgia / Q000188:drug therapy* / Q000503:physiopathology; D017288:Pain Threshold; D010812:Physical Stimulation; D017207:Rats, Sprague-Dawley; D013127:Spinal Nerves / Q000293:injuries; D013841:Thiazepines / Q000627:therapeutic use*; D014110:Touch
chemical_list: D018712:Analgesics, Non-Narcotic; D000929:Antidepressive Agents, Tricyclic; D013841:Thiazepines; C050504:tianeptine
keywords: Allodynia; Neuropathic pain; Rat model; Tianeptine