title: Regulation of Lymph Node Vascular-Stromal Compartment by Dendritic Cells.
abstract: During normal and pathologic immune responses, lymph nodes can swell considerably. The lymph node vascular-stromal compartment supports and regulates the developing immune responses and undergoes dynamic expansion and remodeling. Recent studies have shown that dendritic cells (DCs), best known for their antigen presentation roles, can directly regulate the vascular-stromal compartment, pointing to a new perspective on DCs as facilitators of lymphoid tissue function. Here, we review the phases of lymph node vascular-stromal growth and remodeling during immune responses, discuss the roles of DCs, and discuss how this understanding can potentially be used for developing novel therapeutic approaches.
authors.affiliation: Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY 10021, USA; Physiology, Biophysics and Systems Biology Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.
authors.forename: Dragos C
authors.initials: DC
authors.lastname: Dasoveanu
authors.affiliation: Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY 10021, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA; Weill Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD Program, New York, NY 10065, USA.
authors.forename: William D
authors.initials: WD
authors.lastname: Shipman
authors.affiliation: Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY 10021, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA; Weill Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD Program, New York, NY 10065, USA.
authors.forename: Jennifer J
authors.initials: JJ
authors.lastname: Chia
authors.affiliation: Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY 10021, USA.
authors.forename: Susan
authors.initials: S
authors.lastname: Chyou
authors.affiliation: Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY 10021, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA; Pediatric Rheumatology, Hospital for Special Surgery, New York, NY 10021, USA; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address: lut@hss.edu.
authors.forename: Theresa T
authors.initials: TT
authors.lastname: Lu
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D000941:Antigens / Q000276:immunology / Q000378:metabolism; D002450:Cell Communication / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007109:Immunity; D007167:Immunotherapy / Q000379:methods* / Q000639:trends; D008198:Lymph Nodes / Q000276:immunology*; D010455:Peptides / Q000276:immunology / Q000378:metabolism; D017154:Stromal Cells / Q000502:physiology*; D066253:Vascular Remodeling / Q000276:immunology*
chemical_list: D000941:Antigens; D010455:Peptides