title: Adverse safety events in patients with Chronic Kidney Disease (CKD).
abstract: Chronic kidney disease (CKD) confers a higher risk of adverse safety events as a result of many factors including medication dosing errors and use of nephrotoxic drugs, which can cause kidney injury and renal function decline. CKD patients may also have comorbidities such as hypertension and diabetes for which they require more frequent care from different providers, and for which standard, but countervailing treatments, may put them at risk for adverse safety events. Areas covered: In addition to the well-known agents such as iodinated radiocontrast, antimicrobials, diuretics and angiotensin converting enzyme (ACE) inhibitors which can directly affect renal function, safety considerations in the treatment of common CKD complications such as anemia, diabetes, analgesia and thrombosis will also be discussed. Expert opinion: Better outcomes in CKD may be achieved by alerting care providers to the special care needs of kidney patients and encouraging patients to self-manage their disease with the decision support of multidisciplinary patient care teams.
authors.affiliation: a General Internal Medicine , University of Maryland Medical System Ringgold standard institution , Baltimore , MD , USA.
authors.forename: Ada
authors.initials: A
authors.lastname: Offurum
authors.affiliation: a General Internal Medicine , University of Maryland Medical System Ringgold standard institution , Baltimore , MD , USA.
authors.forename: Lee-Ann
authors.initials: LA
authors.lastname: Wagner
authors.affiliation: a General Internal Medicine , University of Maryland Medical System Ringgold standard institution , Baltimore , MD , USA.
authors.forename: Tanisha
authors.initials: T
authors.lastname: Gooden
mesh_terms: D003920:Diabetes Mellitus / Q000188:drug therapy / Q000453:epidemiology; D004305:Dose-Response Relationship, Drug; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000453:epidemiology; D007677:Kidney Function Tests; D008508:Medication Errors; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D004364:Pharmaceutical Preparations
keywords: ACE inhibitors; ARBs; CKD; Patient safety; adverse events; anticoagulants; diuretics; eGFR; hypoglycemia; nephrotoxicity; opioids; self-management and patient care teams