title: Angiotensin receptor blockers and breast cancer risk: a meta-analysis.
abstract: BACKGROUND
  Some studies reported that angiotensin receptor blockers (ARBs) reduced the risk of breast cancer. However, other studies did not show similar results.
  
  
  METHODS
  The PubMed and EMBASE databases were searched. The strength of the association between ARBs and the risk of breast cancer was measured by odds ratio (OR) and 95% confidence interval (CI).
  
  
  RESULTS
  Eight eligible studies with 1,994,880 individuals were considered for this meta-analysis. ARBs was not associated with the risk of breast cancer (OR=0.93; 95% CI: 0.81-1.06; I2=86%). In the subgroup analysis of race, a significantly decreased breast cancer risk were observed in Asians (OR=0.62; 95% CI: 0.53-0.73; I2=0%). However, a significantly increased breast cancer risk were observed in Caucasians (OR=1.08; 95% CI: 1.02-1.13; I2=28%).
  
  
  CONCLUSIONS
  This study provided evidence that ARBs was associated with decreased breast cancer in Asians and increased risk of breast cancer in Caucasians.
authors.affiliation: Department of Geriatrics, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China - qianyunfgz@tom.com.
authors.forename: Yun-Feng
authors.initials: YF
authors.lastname: Qian
authors.affiliation: Department of Geriatrics, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China.
authors.forename: Wei-Guo
authors.initials: WG
authors.lastname: Xu
authors.affiliation: Department of Geriatrics, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
mesh_terms: D000368:Aged; D057911:Angiotensin Receptor Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D044466:Asian People; D001943:Breast Neoplasms / Q000139:chemically induced / Q000175:diagnosis / Q000208:ethnology* / Q000517:prevention & control; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D011379:Prognosis; D065840:Protective Factors; D018570:Risk Assessment; D012307:Risk Factors; D044465:White People
chemical_list: D057911:Angiotensin Receptor Antagonists