title: A new phenone from the roots of Paeonia suffruticosa Andrews.
abstract: Thirteen phenones were obtained from the 70% ethanol extract of Paeonia suffruticosa Andrews. Their structures were determined on the basis of chemical methods and spectral data. Among them, compound 1 was identified as a new compound, and compounds 5 and 13 were obtained from genus Paeonia for the first time. The inhibitory effects of isolated compounds (1-12) on nitric oxide (NO) production in lipopolysaccharide-activated macrophages were evaluated, and NO production was suppressed significantly by compound 7.
authors.affiliation: a Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine , Tianjin University of Traditional Chinese Medicine , Tianjin , China.
authors.forename: Liqin
authors.initials: L
authors.lastname: Ding
authors.affiliation: a Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine , Tianjin University of Traditional Chinese Medicine , Tianjin , China.
authors.forename: Qingfei
authors.initials: Q
authors.lastname: Zuo
authors.affiliation: a Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine , Tianjin University of Traditional Chinese Medicine , Tianjin , China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Li
authors.affiliation: b School of Chinese Materia Medica , Tianjin University of Traditional Chinese Medicine , Tianjin , China.
authors.forename: Xinchi
authors.initials: X
authors.lastname: Feng
authors.affiliation: a Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine , Tianjin University of Traditional Chinese Medicine , Tianjin , China.
authors.forename: Xiumei
authors.initials: X
authors.lastname: Gao
authors.affiliation: c School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong , Yantai University , Yantai , China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhao
authors.affiliation: a Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine , Tianjin University of Traditional Chinese Medicine , Tianjin , China.|b School of Chinese Materia Medica , Tianjin University of Traditional Chinese Medicine , Tianjin , China.
authors.forename: Feng
authors.initials: F
authors.lastname: Qiu
mesh_terms: D007659:Ketones / Q000737:chemistry* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D029596:Paeonia / Q000737:chemistry*; D019800:Phenol / Q000737:chemistry* / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D007659:Ketones; D008070:Lipopolysaccharides; D010936:Plant Extracts; D009569:Nitric Oxide; D019800:Phenol
keywords: Paeonia suffruticosa Andrews; nitric oxide; phenones