title: Sigmoid resection with primary anastomosis and ileostomy versus laparoscopic lavage in purulent peritonitis from perforated diverticulitis: outcome analysis in a prospective cohort of 40 consecutive patients.
abstract: OBJECTIVE
  This prospective study aimed to compare outcomes after laparoscopic peritoneal lavage (LPL) and sigmoid resection with primary colorectal anastomosis (RPA).
  
  
  METHODS
  From June 2010 to June 2015, 40 patients presenting with Hinchey III peritonitis from perforated diverticulitis underwent LPL or RPA. Patients with Hinchey II or IV peritonitis and patients who underwent an upfront Hartmann procedure were excluded. Primary endpoint was overall 30-day or in-hospital postoperative morbidity after surgical treatment of peritonitis.
  
  
  RESULTS
  Twenty-five patients underwent RPA and 15 LPL. Overall postoperative morbidity and mortality rates were not significantly different after RPA and LPL (40 vs 67 %, p = 0.19; 4 vs 6.7 %, p = 1, respectively). Intra-abdominal morbidity and reoperation rates were significantly higher after LPL compared to RPA (53 vs 12 %, p < 0.01; 40 vs 4 %, p = 0.02, respectively). Multivariate analysis showed that LPL (p = 0.028, HR = 18.936, CI 95 % = 1.369-261.886) was associated with an increased risk of postoperative intra-abdominal septic morbidity. Among 6 patients who underwent reoperation after LPL, 4 had a Hartmann procedure. All surviving patients who had a procedure requiring stoma creation underwent stoma reversal after a median delay of 92 days after LPL and 72 days after RPA (p = 0.07).
  
  
  CONCLUSIONS
  LPL for perforated diverticulitis is associated with a high risk of inadequate intra-abdominal sepsis control requiring a Hartmann procedure in up to 25 % of patients. RPA appears to be safer and more effective. It may represent the best option in this context.
authors.affiliation: Department of Digestive Surgery and Surgical Oncology, Bicêtre Hospital, Assistance Publique Hôpitaux de Paris, Université Paris-Sud, 78, rue du Général Leclerc, 94275, Le Kremlin Bicêtre, France.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Catry
authors.affiliation: Department of Digestive Surgery and Surgical Oncology, Bicêtre Hospital, Assistance Publique Hôpitaux de Paris, Université Paris-Sud, 78, rue du Général Leclerc, 94275, Le Kremlin Bicêtre, France. antoine.brouquet@bct.aphp.fr.
authors.forename: Antoine
authors.initials: A
authors.lastname: Brouquet
authors.affiliation: Department of Digestive and Oncologic Surgery Hospital Ambroise Paré, Assistance Publique, Hôpitaux de Paris, University Paris-Ouest, Boulogne-Billancourt, France.
authors.forename: Frédérique
authors.initials: F
authors.lastname: Peschaud
authors.affiliation: Department of Digestive and Oncologic Surgery Hospital Ambroise Paré, Assistance Publique, Hôpitaux de Paris, University Paris-Ouest, Boulogne-Billancourt, France.
authors.forename: Karina
authors.initials: K
authors.lastname: Vychnevskaia
authors.affiliation: Department of Digestive Surgery and Surgical Oncology, Bicêtre Hospital, Assistance Publique Hôpitaux de Paris, Université Paris-Sud, 78, rue du Général Leclerc, 94275, Le Kremlin Bicêtre, France.
authors.forename: Solafah
authors.initials: S
authors.lastname: Abdalla
authors.affiliation: Department of Digestive and Oncologic Surgery Hospital Ambroise Paré, Assistance Publique, Hôpitaux de Paris, University Paris-Ouest, Boulogne-Billancourt, France.
authors.forename: Robert
authors.initials: R
authors.lastname: Malafosse
authors.affiliation: Department of Digestive Surgery and Surgical Oncology, Bicêtre Hospital, Assistance Publique Hôpitaux de Paris, Université Paris-Sud, 78, rue du Général Leclerc, 94275, Le Kremlin Bicêtre, France.
authors.forename: Benoit
authors.initials: B
authors.lastname: Lambert
authors.affiliation: Department of Digestive Surgery and Surgical Oncology, Bicêtre Hospital, Assistance Publique Hôpitaux de Paris, Université Paris-Sud, 78, rue du Général Leclerc, 94275, Le Kremlin Bicêtre, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Costaglioli
authors.affiliation: Department of Digestive Surgery and Surgical Oncology, Bicêtre Hospital, Assistance Publique Hôpitaux de Paris, Université Paris-Sud, 78, rue du Général Leclerc, 94275, Le Kremlin Bicêtre, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Benoist
authors.affiliation: Department of Digestive Surgery and Surgical Oncology, Bicêtre Hospital, Assistance Publique Hôpitaux de Paris, Université Paris-Sud, 78, rue du Général Leclerc, 94275, Le Kremlin Bicêtre, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Penna
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000714:Anastomosis, Surgical; D012809:Colon, Sigmoid / Q000601:surgery*; D004238:Diverticulitis / Q000150:complications / Q000601:surgery*; D005260:Female; D006801:Humans; D007081:Ileostomy / Q000379:methods*; D007416:Intestinal Perforation / Q000150:complications / Q000601:surgery*; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010533:Peritoneal Lavage; D010538:Peritonitis / Q000150:complications / Q000601:surgery*; D011182:Postoperative Care; D011300:Preoperative Care; D011446:Prospective Studies; D012307:Risk Factors; D016896:Treatment Outcome
keywords: Diverticulitis; Hinchey III; Peritoneal lavage; Purulent peritonitis; Sigmoid resection