title: Demystifying the role of mitochondria in senescence.
abstract: In a study published in The EMBO Journal, we demonstrated that mitochondria are necessary for the proinflammatory phenotype of senescence. Furthermore, we identified a new senescence-regulatory pathway involving mTOR-dependent mitochondrial biogenesis. These data highlight mitochondria as targets for interventions that counteract the pro-aging effects of senescence while preserving tumor suppression.
authors.affiliation: Institute for Cell and Molecular Biosciences, Newcastle University Institute for Ageing, Newcastle University , Newcastle upon Tyne, United Kingdom.
authors.forename: Clara
authors.initials: C
authors.lastname: Correia-Melo
authors.affiliation: Institute for Cell and Molecular Biosciences, Newcastle University Institute for Ageing, Newcastle University , Newcastle upon Tyne, United Kingdom.
authors.forename: João F
authors.initials: JF
authors.lastname: Passos
keywords: Ageing; mTOR; mitochondria; senescence