title: Vancomycin in infusion during vitrectomy in surgical treatment of acute postoperative and posttraumatic endophthalmitis.
abstract: Endophthalmitis is potentially devastating intraocular inflammation following eye trauma or surgery. We describe the visual outcomes and causative pathogens in acute bacterial postoperative and posttraumatic endophthalmitis treated with immediate pars plana vitrectomy (PPV) with Vancomycin dissolved in the infusion fluid.
  
  
  
  Clinical records of consecutive 30 patients with postoperative endophthalmitis and 15 patients with posttraumatic endophthalmitis were evaluated. Vancomycin was administered constantly in the infusion fluid at the time of complete PPV. Cultures were prepared from anterior chamber paracentesis. The mean follow-up period was 13 months.
  
  
  
  The visual acuities were improved in 38 cases (84 %) and remained stable in seven cases (16 %). Median post-PPV visual acuity was 1.0 logMAR in a group with postoperative endophthalmitis and 1.3 logMAR in a group with posttraumatic endophthalmitis (p < 0.05). Twenty cases (44 %) were culture-positive (Staphylococcus, Streptococcus, Enterococcus and Bacillus spp).
  
  
  
  Early PPV with Vanomycin in infusion leads to vision improvement in patients with both posttraumatic and postoperative endophthalmitis. In our series of 45 cases culture was positive only in half of the cases.
authors.affiliation: Department of General Ophthalmology, Medical University of Lublin, ul. Chmielna 1, 20-079, Lublin, Poland.|Department of Experimental Pharmacology, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
authors.forename: Robert
authors.initials: R
authors.lastname: Rejdak
authors.affiliation: Department of General Ophthalmology, Medical University of Lublin, ul. Chmielna 1, 20-079, Lublin, Poland.|Department of Didactics and Medical Simulation, Human Anatomy Chair, Medical University of Lublin, Lublin, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Choragiewicz
authors.affiliation: Department of General Ophthalmology, Medical University of Lublin, ul. Chmielna 1, 20-079, Lublin, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Kalinowska
authors.affiliation: Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Koss
authors.affiliation: Department of Public Health, Medical University of Lublin, Lublin, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Ksiazek
authors.affiliation: Department of General Ophthalmology, Medical University of Lublin, ul. Chmielna 1, 20-079, Lublin, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Moneta-Wielgos
authors.affiliation: Human Anatomy Department, Medical University of Lublin, Lublin, Poland.
authors.forename: Ryszard
authors.initials: R
authors.lastname: Maciejewski
authors.affiliation: Department of Ophthalmology, University of Rostock, Rostock, Germany.
authors.forename: Anselm G
authors.initials: AG
authors.lastname: Jünemann
authors.affiliation: Department of General Ophthalmology, Medical University of Lublin, ul. Chmielna 1, 20-079, Lublin, Poland. katarzynanowomiejska@mailcity.com.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Nowomiejska
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D009877:Endophthalmitis / Q000209:etiology / Q000382:microbiology / Q000601:surgery*; D015818:Eye Infections, Bacterial / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy*; D012189:Retrospective Studies; D013210:Staphylococcus; D013291:Streptococcus; D014640:Vancomycin / Q000627:therapeutic use*; D014792:Visual Acuity; D014821:Vitrectomy; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin
keywords: Endophthalmitis; Ocular trauma; Vitrectomy