title: [A Case of Advanced Gastric Cancer with Severe Jaundice from Multiple Liver Metastases That Was Significantly Improved after Capecitabine plus Oxaliplatin Treatment].
abstract: A 74-year-old man with advanced gastric cancer was admitted to our hospital. His liver function was impaired(total bilirubin 1.6mg/dL)with multiple liver metastases. He was treated with chemotherapy of S-1 plus cisplatin but it was discon- tinued due to severe diarrhea(CTCAE Grade 3)on day 6 and his liver dysfunction progressed(total bilirubin 10.3mg/dL). After his diarrhea improved, he was treated with capecitabine plus oxaliplatin(capecitabine 3,600mg/day on day 1-14, oxaliplatin 130mg/m2 on day 1, q3 weeks). His severe jaundice and general condition improved without severe non-hematological toxicity, and he was ultimately discharged. He achieved a partial response(RECIST v1.1)after capecitabine plus oxaliplatin treatment, and this therapy has been continued for 15 months. This case suggests that capecitabine plus oxaliplatin may be beneficial even in advanced gastric cancer patients with impaired liver function from multiple liver metastases.
authors.affiliation: Dept. of Gastroenterology and Hematology, University of Toyama.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Takagi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ando
authors.forename: Ayumu
authors.initials: A
authors.lastname: Hosokawa
authors.forename: Takaaki
authors.initials: T
authors.lastname: Nishino
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mihara
authors.forename: Hiroki
authors.initials: H
authors.lastname: Yoshita
authors.forename: Naokatsu
authors.initials: N
authors.lastname: Nakada
authors.forename: Sohachi
authors.initials: S
authors.lastname: Nanjo
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Miura
authors.forename: Shinya
authors.initials: S
authors.lastname: Kajiura
authors.forename: Haruka
authors.initials: H
authors.lastname: Fujinami
authors.forename: Toshiro
authors.initials: T
authors.lastname: Sugiyama
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000069287:Capecitabine / Q000008:administration & dosage; D006801:Humans; D007565:Jaundice / Q000209:etiology*; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D009367:Neoplasm Staging; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D000069287:Capecitabine