title: A Real-Life Experience of Bevacizumab in Elderly Women With Advanced Ovarian Carcinoma.
abstract: This study aimed to assess the tolerance of bevacizumab (BEVA) among older ovarian cancer patients in daily clinical practice and identify a subpopulation of patients with a high risk of severe adverse effects.
  
  
  
  Consecutive patients with a pathologically proven high-grade serous ovarian, tubal, or peritoneal carcinoma who received BEVA between January 2006 and June 2014 were included in a retrospective analysis.
  
  
  
  Among 86 BEVA-treated patients, 42 (48.8%) received concomitant chemotherapy, 26 (30%) had baseline arterial hypertension (HTN), and 33 (38.4%) were considered elderly (>70 years). Incidence of arterial, venous thromboembolism, hemorrhage, and bowel perforation were 2%, 8%, 12%, and 0%, respectively, and was not related to age. Incidence of severe (NCI-CTC v4 G3-4) HTN was significantly higher in elderly patients than in younger ones (39%; 95% confidence interval [CI], 22%-56% vs 17%; 95% CI, 7%-27%) (P = 0.017 by χ test) and in patients with baseline HTN (P < 0.05). Twenty-three percent of younger patients had baseline HTN compared with 42% of older ones (P = 0.052). Among patients without baseline HTN, older age was not associated with increased risk of severe HTN. However, incidence of severe HTN reached 71% (95% CI, 47%-95%) in older patients with baseline HTN. Exploratory analysis indicates that progression-free survival was similar in younger and older patients.
  
  
  
  Bevacizumab is feasible in patients older than 70 years with advanced ovarian carcinoma. More attention must be paid to elderly patients with baseline HTN.
authors.affiliation: Departments of *Medical Oncology and †Gynecology Oncology, Cochin-Port Royal Hospital, Sorbonne Paris-Cité University, Cancer Personalized Medicine, Assistance Publique-Hôpitaux de Paris; and ‡Women Cancer Clinical Research Unit, Hotel Dieu, Paris, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Beinse
authors.forename: George
authors.initials: G
authors.lastname: Emile
authors.forename: Anatole
authors.initials: A
authors.lastname: Cessot
authors.forename: Pascaline
authors.initials: P
authors.lastname: Boudou-Rouquette
authors.forename: Olivier
authors.initials: O
authors.lastname: Huillard
authors.forename: Nathaniel E B
authors.initials: NE
authors.lastname: Saidu
authors.forename: Bruno
authors.initials: B
authors.lastname: Borghese
authors.forename: François
authors.initials: F
authors.lastname: Goldwasser
authors.forename: Eric
authors.initials: E
authors.lastname: Pujade Lauraine
authors.forename: Jérôme
authors.initials: J
authors.lastname: Alexandre
mesh_terms: D000368:Aged; D000074322:Antineoplastic Agents, Immunological / Q000627:therapeutic use*; D000068258:Bevacizumab / Q000627:therapeutic use*; D002277:Carcinoma / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications / Q000188:drug therapy*; D012189:Retrospective Studies
chemical_list: D000074322:Antineoplastic Agents, Immunological; D000068258:Bevacizumab