title: Efficacy of Zinc Sulfate in Peptic Ulcer Disease: A Randomized Double-Blind Clinical Trial Study.
abstract: BACKGROUND
  Peptic ulcer is a common disease that affects millions of people worldwide. Considering its global prevalence finding new approach for treating is important.
  
  
  OBJECTIVE
  The aim of this study was to investigate the effect of zinc sulfate on gastric and duodenal ulcer treatment.
  
  
  METHODS
  This double-blind clinical trial study was done on 90 patients who were admitted to the gastrointestinal endoscopy clinic of Tohid hospital in Sanandaj, Iran. All patients were diagnosed with gastric and duodenal ulcers. They were randomly divided into two-intervention and control groups, using block randomization with block sizes of 4. Patients and researcher were unaware of the grouping. To assess the level of zinc, blood samples were taken. In case of positive Rapid Urease Test (RUT), triple therapy regimen including amoxicillin, clarithromycin and omeprazole was administered for two weeks. For intervention group in addition to "triple therapy", an oral dose of Zinc Sulfate 220mg capsules were administered daily, while the control group received placebo capsules.
  
  
  RESULTS
  A total of 54.5% and 57% of the patients in the intervention and control groups had gastric ulcer respectively. The Rapid Urease Test (RUT) result of 72.7% of intervention group and 83.3% of control group was positive (p = 0.24). Serum zinc level of 20.9% of intervention group and 35.7% of control group was lower than the normal level (p = 0.13). The mean of serum zinc level of intervention group and control group were 81.9 and 78.9 mg dL respectively (p = 0.4). After intervention, peptic ulcer in 81.8% of the intervention group and 83.3% of the control groups were improved (p= 0.85). Response to treatment were higher in patients with normal zinc levels compared to patients with abnormal levels (77.5% vs. 22.5%, p=0.019).
  
  
  CONCLUSIONS
  A daily dose of 220mg zinc sulfate was not significantly effective on peptic ulcer. However, patients with normal zinc levels had better ulcer treatment.
authors.affiliation: Kurdistan Liver and Digestive Research Centre, Kurdistan University of Medical Sciences , Sanandaj, Iran .
authors.forename: Kambiz
authors.initials: K
authors.lastname: Yazdanpanah
authors.affiliation: Kurdistan Liver and Digestive Research Centre, Kurdistan University of Medical Sciences , Sanandaj, Iran .
authors.forename: Baran
authors.initials: B
authors.lastname: Parhizkar
authors.affiliation: Kurdistan Liver and Digestive Research Centre, Kurdistan University of Medical Sciences , Sanandaj, Iran .
authors.forename: Farshad
authors.initials: F
authors.lastname: Sheikhesmaeili
authors.affiliation: Kurdistan Liver and Digestive Research Centre, Kurdistan University of Medical Sciences , Sanandaj, Iran .
authors.forename: Mohammad
authors.initials: M
authors.lastname: Roshani
authors.affiliation: Residence of Internal Medicine, Faculty of Medicine, Kurdistan University of Medical Sciences , Sanandaj, Iran .
authors.forename: Morteza
authors.initials: M
authors.lastname: Nayebi
authors.affiliation: Health Management Department, Tohid Hospital, Kurdistan University of Medical Sciences , Sanandaj, Iran .
authors.forename: Fardin
authors.initials: F
authors.lastname: Gharibi
keywords: Gastro duodenal ulcer; Mineral nutrients; Treatment