title: Brazilian Tabernaemontana genus: Indole alkaloids and phytochemical activities.
abstract: The Tabernaemontana genus belongs to the family Apocynaceae comprising about 100 species spread throughout tropical and subtropical regions around the world including Brazil, which contains around 40 species spread all over its territory. Because of the territorial space and climate diversity, these species already identified in Brazil are the largest collection of Tabernaemontana, which are representative (about 30%) of worldwide distribution. The monoterpene indole alkaloids present as major secondary components in all parts of the plants of the genus Tabernaemontana, have attracted the attention of the scientific community for new alkaloids derivatives and bioactivities. This review covers relevant references about Tabernaemontana species found in Brazil, its geographical distribution, occurrence of monoterpene alkaloids and phytochemical activities. Additional information about the South American species activities are also reported in this review.
authors.affiliation: Laboratory of Biotechnology of Natural and Synthetic Products, Institute of Biotechnology, University of Caxias do Sul, Caxias do Sul, Brazil.
authors.forename: Flávio F
authors.initials: FF
authors.lastname: Marinho
authors.affiliation: Departamento de Biologia Vegetal, Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, Brazil.
authors.forename: André Olmos
authors.initials: AO
authors.lastname: Simões
authors.affiliation: Laboratory of Biotechnology of Natural and Synthetic Products, Institute of Biotechnology, University of Caxias do Sul, Caxias do Sul, Brazil.
authors.forename: Thiago
authors.initials: T
authors.lastname: Barcellos
authors.affiliation: Laboratory of Biotechnology of Natural and Synthetic Products, Institute of Biotechnology, University of Caxias do Sul, Caxias do Sul, Brazil. Electronic address: sidnei.moura@ucs.br.
authors.forename: Sidnei
authors.initials: S
authors.lastname: Moura
mesh_terms: D001938:Brazil; D026121:Indole Alkaloids / Q000494:pharmacology*; D039821:Monoterpenes / Q000494:pharmacology*; D064209:Phytochemicals / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology; D030014:Tabernaemontana / Q000737:chemistry* / Q000145:classification
chemical_list: D026121:Indole Alkaloids; D039821:Monoterpenes; D064209:Phytochemicals; D010936:Plant Extracts
keywords: Bioactivity; Brazilian species; Monoterpene indole alkaloids; Phytogeographic domains; Tabernaemontana