title: From Normal Skin to Squamous Cell Carcinoma: A Quest for Novel Biomarkers.
abstract: Squamous cells carcinoma (SCC) is the second most frequent of the keratinocyte-derived malignancies after basal cell carcinoma and is associated with a significant psychosocial and economic burden for both the patient himself and society. Reported risk factors for the malignant transformation of keratinocytes and development of SCC include ultraviolet light exposure, followed by chronic scarring and inflammation, exposure to chemical compounds (arsenic, insecticides, and pesticides), and immune-suppression. Despite various available treatment methods and recent advances in noninvasive or minimal invasive diagnostic techniques, the risk recurrence and metastasis are far from being negligible, even in patients with negative histological margins and lymph nodes. Analyzing normal, dysplastic, and malignant keratinocyte proteome holds special promise for novel biomarker discovery in SCC that could be used in the future for early detection, risk assessment, tumor monitoring, and development of targeted therapeutic strategies.
authors.affiliation: Department of Dermatology and Allergology, Elias Emergency University Hospital, Bucharest, Romania.
authors.forename: Vlad
authors.identifier: 0000-0002-5671-9378
authors.initials: V
authors.lastname: Voiculescu
authors.affiliation: Department of Biochemistry, Faculty of Dental Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: Bogdan
authors.identifier: 0000-0002-7565-9964
authors.initials: B
authors.lastname: Calenic
authors.affiliation: Dermatology Research Laboratory, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: Mihaela
authors.initials: M
authors.lastname: Ghita
authors.affiliation: Department of Dermatology and Allergology, Elias Emergency University Hospital, Bucharest, Romania.
authors.forename: Mihai
authors.identifier: 0000-0002-5438-0817
authors.initials: M
authors.lastname: Lupu
authors.affiliation: Department of Oral and Maxillofacial Surgery, "Carol Davila" Central Military Emergency Hospital, Bucharest, Romania.
authors.forename: Ana
authors.identifier: 0000-0003-4200-3069
authors.initials: A
authors.lastname: Caruntu
authors.affiliation: Department of Oral and Maxillofacial Surgery, "Carol Davila" Central Military Emergency Hospital, Bucharest, Romania.
authors.forename: Liliana
authors.initials: L
authors.lastname: Moraru
authors.affiliation: Department of Physiology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: Suzana
authors.initials: S
authors.lastname: Voiculescu
authors.affiliation: Department of Dermatology and Allergology, Elias Emergency University Hospital, Bucharest, Romania.
authors.forename: Alexandra
authors.identifier: 0000-0002-1749-4102
authors.initials: A
authors.lastname: Ion
authors.affiliation: Department of Biochemistry, Faculty of Dental Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: Maria
authors.initials: M
authors.lastname: Greabu
authors.affiliation: Department of Medical Chemistry and Biochemistry, Faculty of Medicine, Medical University, Sofia, Bulgaria.
authors.forename: Nikolay
authors.identifier: 0000-0002-4351-5579
authors.initials: N
authors.lastname: Ishkitiev
authors.affiliation: Dermatology Research Laboratory, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania; Department of Physiology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: Constantin
authors.identifier: 0000-0003-4530-7965
authors.initials: C
authors.lastname: Caruntu
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D002273:Carcinogens / Q000633:toxicity; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000209:etiology / Q000235:genetics / Q000378:metabolism; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D020543:Proteome / Q000235:genetics / Q000378:metabolism; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000235:genetics / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D002273:Carcinogens; D020543:Proteome