title: EEG Dominant Frequency Peak Differentiates Between Alzheimer's Disease and Frontotemporal Lobar Degeneration.
abstract: We investigated the power of EEG as biomarker in differential diagnosis of Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD). EEG was recorded from 106 patients with AD or FTLD, of which 37 had a definite diagnosis, and 40 controls. Dominant frequency peaks were extracted for all 19 channels, for each subject. The average frequency of the largest dominant frequency peaks (maxpeak) was significantly lower in AD than FTLD patients and controls. Based on ROC analysis, classification could be made with diagnostic accuracy of 78.9%. Our findings show that quantitative analysis of EEG maxpeak frequency is an easy and useful measure for differential dementia diagnosis.
authors.affiliation: Reference Center for Biological Markers of Dementia (BIODEM), Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Wilrijk, Belgium.
authors.forename: Joery
authors.initials: J
authors.lastname: Goossens
authors.affiliation: Center for Neurosciences, Vrije Universiteit Brussel, Brussel, Belgium.
authors.forename: Jorne
authors.initials: J
authors.lastname: Laton
authors.affiliation: Center for Neurosciences, Vrije Universiteit Brussel, Brussel, Belgium.
authors.forename: Jeroen
authors.initials: J
authors.lastname: Van Schependom
authors.affiliation: Center for Neurosciences, Vrije Universiteit Brussel, Brussel, Belgium.
authors.forename: Jeroen
authors.initials: J
authors.lastname: Gielen
authors.affiliation: Reference Center for Biological Markers of Dementia (BIODEM), Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Wilrijk, Belgium.
authors.forename: Hanne
authors.initials: H
authors.lastname: Struyfs
authors.affiliation: Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerpen, Belgium.|Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Wilrijk, Belgium.|Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Wilrijk, Belgium.
authors.forename: Sara
authors.initials: S
authors.lastname: Van Mossevelde
authors.affiliation: Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerpen, Belgium.|Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Wilrijk, Belgium.|Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Wilrijk, Belgium.
authors.forename: Tobi
authors.initials: T
authors.lastname: Van den Bossche
authors.affiliation: Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerpen, Belgium.
authors.forename: Johan
authors.initials: J
authors.lastname: Goeman
authors.affiliation: Reference Center for Biological Markers of Dementia (BIODEM), Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Wilrijk, Belgium.|Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerpen, Belgium.|Biobank, Institute Born-Bunge, University of Antwerp, Wilrijk, Belgium.
authors.forename: Peter Paul
authors.initials: PP
authors.lastname: De Deyn
authors.affiliation: Biobank, Institute Born-Bunge, University of Antwerp, Wilrijk, Belgium.
authors.forename: Anne
authors.initials: A
authors.lastname: Sieben
authors.affiliation: Biobank, Institute Born-Bunge, University of Antwerp, Wilrijk, Belgium.
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Martin
authors.affiliation: Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Wilrijk, Belgium.|Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Wilrijk, Belgium.
authors.forename: Christine
authors.initials: C
authors.lastname: Van Broeckhoven
authors.affiliation: Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Wilrijk, Belgium.|Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Wilrijk, Belgium.
authors.forename: Julie
authors.initials: J
authors.lastname: van der Zee
authors.affiliation: Reference Center for Biological Markers of Dementia (BIODEM), Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Wilrijk, Belgium.|Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerpen, Belgium.
authors.forename: Sebastiaan
authors.initials: S
authors.lastname: Engelborghs
authors.affiliation: Center for Neurosciences, Vrije Universiteit Brussel, Brussel, Belgium.
authors.forename: Guy
authors.initials: G
authors.lastname: Nagels
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D015331:Cohort Studies; D003937:Diagnosis, Differential; D004569:Electroencephalography; D005260:Female; D057174:Frontotemporal Lobar Degeneration / Q000175:diagnosis* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D012372:ROC Curve
keywords: Alzheimer’s disease; biomarkers; differential diagnosis; electroencephalography; frontotemporal lobardegeneration