title: Molecular Modeling and Structural Analysis of Arylesterase ofAncylostoma Duodenale.
abstract: Parasitic worm infection of humans is one of the most commonly prevalent helminth infection that has imposed great impact on society and public health in the developing world. The two species of hookworm, namelyAncylostoma duodenaleandNecator americanusmay be primarily responsible for causing parasitic infections in human beings. The highly prevalent areas forAncylostoma duodenaleinfections are mainly India, Middle East, Australia, northern Africa and other parts of the world. The serum arylesterases/paraoxonases are family of enzymes that is involved in the hydrolysis of a number of organophosphorus insecticides to the nontoxic products. The participation of the enzymes in the breakdown of a variety of organophosphate substrates that is generally made up of paraoxon and numerous aromatic carboxylic acid esters (e.g., phenyl acetate), and hence combats the toxic effect of organophosphates. The aim of the present investigation is to evaluate the arylesterases ofAncylostoma duodenalegiving special importance to structure generation, validation of the generated models, distribution of secondary structural elements and positive charge distribution over the structure. By the implementation of comparative modeling approach we propose the first molecular model structure of arylesterases ofAncylostoma duodenale.
authors.affiliation: Department of Pharmacy, Gupta College of Technological Sciences, Ashram More, G.T. Road, Asansol-713301; Indian Institute of Human and Social Sciences, Sitarampur, Asansol-713359.
authors.forename: Subhamay
authors.initials: S
authors.lastname: Panda
authors.affiliation: Indian Institute of Human and Social Sciences, Sitarampur, Asansol-713359; Department of Physics, NSHM Faculty of Engineering & Technology, NSHM Knowledge Campus, Durgapur-713212.
authors.forename: Santamay
authors.initials: S
authors.lastname: Panda
authors.affiliation: Department of Pharmacy, Gupta College of Technological Sciences, Ashram More, G.T. Road, Asansol-713301.
authors.forename: Leena
authors.initials: L
authors.lastname: Kumari
keywords: Ancylostoma duodenale; Arylesterases; Helminthiasis; Molecular model; Paraoxonase; Protein structure