title: Association of Interleukin-23 Receptor Gene Single Nucleotide Polymorphisms with Ankylosing Spondylitis.
abstract: OBJECTIVE
  It has been shown previously that the IL-23 receptor (IL-23R) variants are associated with ankylosing spondylitis (AS). It is unknown whether IL-23R is associated with AS in the Chinese population. The present study was performed to examine the association of IL-23R gene polymorphisms with susceptibility to AS in the Chinese population.
  
  
  METHODS
  A total of 157 Chinese Han patients with AS and 150 ethnically matched healthy controls were enrolled. All patients were diagnosed with AS according to the modified New York criteria. 8 single nucleotide polymorphisms (SNPs) of the IL-23R gene cluster were genotyped.
  
  
  RESULTS
  None of the 8 IL-23R SNPs were found to be associated with AS in the Chinese population.
  
  
  CONCLUSIONS
  The association of IL-23R and AS that is seen in Caucasian patients with AS is not present in Chinese patients with AS.
authors.affiliation: Department of Rheumatology, First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, Fujian, China.
authors.forename: Song-Sen
authors.initials: SS
authors.lastname: Su
authors.affiliation: Department of Rheumatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Su-Li
authors.initials: SL
authors.lastname: Wang
authors.affiliation: Department of Rheumatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Liang-Jing
authors.initials: LJ
authors.lastname: Lu
authors.affiliation: Department of Rheumatology, the Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China 267sss@163.com.
authors.forename: Ling
authors.initials: L
authors.lastname: Lin
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018123:Receptors, Interleukin / Q000235:genetics*; D013167:Spondylitis, Ankylosing / Q000235:genetics*
chemical_list: C515500:IL23R protein, human; D018123:Receptors, Interleukin
keywords: IL-23R; ankylosing spondylitis; genetics