title: Engineered fatty acid catabolism for fuel and chemical production.
abstract: Fatty acid oxidation pathways are attractive for metabolic engineering purposes due to their cyclic nature as well as their reactions that allow for the selective functionalization of alkyl chains. These characteristics allow for the production of various chemicals, such as alcohols, alkanes, ketones and hydroxyacids, in a wide range of carbon numbers. To this end, the α-, β-, and ω-oxidation pathways have been engineered for use in various hosts. Furthermore, the β-oxidation pathway has been engineered to operate in reverse, resulting in a promising carbon chain elongation platform. This review will describe the recent progress in metabolic engineering strategies for the production of chemicals through these fatty acid oxidation pathways.
authors.affiliation: Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX, USA.
authors.forename: Seohyoung
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX, USA.
authors.forename: Seokjung
authors.initials: S
authors.lastname: Cheong
authors.affiliation: Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Chou
authors.affiliation: Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX, USA; Department of Bioengineering, Rice University, Houston, TX, USA. Electronic address: Ramon.Gonzalez@rice.edu.
authors.forename: Ramon
authors.initials: R
authors.lastname: Gonzalez
mesh_terms: D000438:Alcohols / Q000378:metabolism; D000818:Animals; D001674:Bioelectric Energy Sources / Q000382:microbiology; D002626:Chemistry, Pharmaceutical / Q000379:methods* / Q000639:trends; D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics; D060847:Metabolic Engineering / Q000379:methods*; D010084:Oxidation-Reduction
chemical_list: D000438:Alcohols; D005227:Fatty Acids