title: Functions of Type II Thioesterases in Bacterial Polyketide Biosynthesis.
abstract: Many polyketides show biological activities and have thus been applied in clinics, as food additives, and in agriculture. Type II thioesterases (TEIIs) play an important role in polyketide biosynthesis. Most TEIIs belong to α/β-hydrolase family and usually contain a catalytic triad Ser-His-Asp. In polyketide biosynthesis, TEIIs can play an editing role by removal of aberrant non-extendable acyl units in elongation steps, a starter unit selection role by removal of unfavored starter acyl units in initiation steps, and a releasing role by removal of final product in termination steps. Complementation of TEIIs has been observed and applied.
authors.forename: Hong-Dou
authors.initials: HD
authors.lastname: Luo
authors.forename: Mei-Ying
authors.initials: MY
authors.lastname: Jin
authors.affiliation: Hangzhou Zhongmei Huadong Pharmaceutical Co., LTD, Hangzhou, Zhejiang 310011, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wu
authors.affiliation: College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Jiang
mesh_terms: D000595:Amino Acid Sequence; D064429:Fatty Acid Synthases / Q000378:metabolism*; D010170:Palmitoyl-CoA Hydrolase / Q000378:metabolism; D048630:Polyketide Synthases / Q000378:metabolism; D061065:Polyketides / Q000378:metabolism*; D013302:Streptomyces / Q000201:enzymology / Q000378:metabolism*; D013869:Thiolester Hydrolases / Q000378:metabolism*
chemical_list: D061065:Polyketides; D048630:Polyketide Synthases; D064429:Fatty Acid Synthases; D013869:Thiolester Hydrolases; C022738:thioesterase II; D010170:Palmitoyl-CoA Hydrolase