title: Plasma cytokines IL-6, IL-8, and IL-10 are associated with the development of acute respiratory distress syndrome in patients with severe traumatic brain injury.
abstract: Patients with severe traumatic brain injury (TBI) are at risk of the development of acute respiratory distress syndrome (ARDS). TBI and ARDS pathophysiologic mechanisms are known to independently involve significant inflammatory responses. The literature on the association between plasma inflammatory cytokines and ARDS in patients with TBI is sparse.
  
  
  
  The study was a secondary analysis of the safety of a randomized trial of erythropoietin and transfusion threshold in patients with severe TBI. Inflammatory markers within the first 24 hours after injury were compared in patients who developed ARDS and patients without ARDS, using Cox proportional hazards models.
  
  
  
  There were 200 patients enrolled in the study. The majority of plasma and cerebrospinal fluid (CSF) cytokine levels were obtained within 6 hours. Plasma proinflammatory markers IL-6 and IL-8 and anti-inflammatory marker IL-10 were associated with the development of ARDS (adjusted hazard ratio (HR) = 1.55, confidence interval (CI) = 1.14, 2.11, P = 0.005 for IL-6; adjusted HR = 1.32, CI = 1.10, 1.59, P = 0.003 for IL-8).
  
  
  
  Plasma markers of IL-6, IL-8, and IL-10 are associated with ARDS in patients with severe TBI.
  
  
  
  NCT00313716 registered 4/2006.
authors.affiliation: Department of Emergency Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA. iaisiku@partners.org.
authors.forename: Imo P
authors.initials: IP
authors.lastname: Aisiku
authors.affiliation: Division of Biostatistics, University of Texas School of Public Health, Houston, TX, USA.
authors.forename: Jose-Miguel
authors.initials: JM
authors.lastname: Yamal
authors.affiliation: Department of Emergency Medicine and Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
authors.forename: Pratik
authors.initials: P
authors.lastname: Doshi
authors.affiliation: Department of Basic Vision Sciences, College of Optometry Texas Institute for Measurement Evaluation and Statistics, University of Houston, Houston, TX, USA.
authors.forename: Julia S
authors.initials: JS
authors.lastname: Benoit
authors.affiliation: Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Shankar
authors.initials: S
authors.lastname: Gopinath
authors.affiliation: Department of Pathology, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Jerry C
authors.initials: JC
authors.lastname: Goodman
authors.affiliation: Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Claudia S
authors.initials: CS
authors.lastname: Robertson
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000032:analysis* / Q000097:blood; D000070642:Brain Injuries, Traumatic / Q000503:physiopathology*; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000032:analysis / Q000097:blood; D015850:Interleukin-6 / Q000032:analysis / Q000097:blood; D016209:Interleukin-8 / Q000032:analysis / Q000097:blood; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D012128:Respiratory Distress Syndrome / Q000503:physiopathology*
chemical_list: D015415:Biomarkers; C508609:IL10 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D016209:Interleukin-8; D016753:Interleukin-10
keywords: ALI; ARDS; CSF; Cytokines; Plasma; TBI