title: Expression of EGF, EGFR, and proliferation in placentas from pregnancies complicated with preeclampsia.
abstract: OBJECTIVE
  To investigate proliferation, EGF and EGFR expression of villous trophoblast (VTB), decidual cells (DC), and extravillous trophoblast (EVTB) in the placentas from pregnancies complicated with preeclampsia (PE) and to compare them with placentas from normal pregnancies.
  
  
  METHODS
  Twenty-nine PE placentas and 19 control placentas were studied for EGF and EGFR immunohistochemical expression (noted as week, moderate or strong). Proliferation was expressed as the proliferation index. The CK7 antibody was used to distinguish DC from EVTB.
  
  
  RESULTS
  DC and EVTB proliferation was significantly higher in PE placentas. EGFR and EGF expression showed no significant difference.
  
  
  CONCLUSIONS
  Higher DC and EVTB proliferation in PE could contribute to PE development.
authors.affiliation: a Department of Gynecology and Obstetrics , Split University Hospital Center , Split , Croatia.
authors.forename: Indira
authors.initials: I
authors.lastname: Kosovic
authors.affiliation: b Department of Pathology , Split University Hospital Center , Split , Croatia.
authors.forename: Ivana Kuzmic
authors.initials: IK
authors.lastname: Prusac
authors.affiliation: c School of Medicine , University of Split , Split , Croatia.
authors.forename: Anna
authors.initials: A
authors.lastname: Berkovic
authors.affiliation: a Department of Gynecology and Obstetrics , Split University Hospital Center , Split , Croatia.
authors.forename: Jelena
authors.initials: J
authors.lastname: Marusic
authors.affiliation: a Department of Gynecology and Obstetrics , Split University Hospital Center , Split , Croatia.
authors.forename: Marko
authors.initials: M
authors.lastname: Mimica
authors.affiliation: b Department of Pathology , Split University Hospital Center , Split , Croatia.
authors.forename: Sandra Zekic
authors.initials: SZ
authors.lastname: Tomas
mesh_terms: D000328:Adult; D049109:Cell Proliferation; D004815:Epidermal Growth Factor / Q000378:metabolism*; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D006801:Humans; D010920:Placenta / Q000378:metabolism* / Q000473:pathology; D011225:Pre-Eclampsia / Q000378:metabolism* / Q000473:pathology; D011247:Pregnancy; D014327:Trophoblasts / Q000378:metabolism / Q000473:pathology
chemical_list: D004815:Epidermal Growth Factor; C512478:EGFR protein, human; D066246:ErbB Receptors
keywords: EGF; EGFR; Preeclampsia; decidual cells; extravillous trophoblast; proliferation