title: Two new C-glucosyl flavonoids from Ziziphus jujube and their anti-inflammatory activity.
abstract: Two new C-glucosyl flavonoids 6''-O-feruloylspinosin and 6''-O-feruloyl-6'''-p-hydroxybenzoylspinosin, together with five known compounds, were isolated from the seeds of Ziziphus jujube (Rhamnaceae family). Their structures were elucidated on the basis of chemical and spectroscopic evidences. Compounds 1-7 showed moderate inhibitory effects against COX-1 and COX-2 enzymes.
authors.affiliation: a School of Pharmacy and Bioengineering , Chengdu University , Chengdu 610106 , China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Fu
authors.affiliation: a School of Pharmacy and Bioengineering , Chengdu University , Chengdu 610106 , China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Ma
authors.affiliation: a School of Pharmacy and Bioengineering , Chengdu University , Chengdu 610106 , China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Chen
authors.affiliation: a School of Pharmacy and Bioengineering , Chengdu University , Chengdu 610106 , China.
authors.forename: Hai-Mei
authors.initials: HM
authors.lastname: Yuan
authors.affiliation: b School of Biology Sciences and Food Technology , Hanshan Normal University , Chaozhou 521041 , China.
authors.forename: Yu-Zhong
authors.initials: YZ
authors.lastname: Zheng
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D052246:Cyclooxygenase 2 Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D012639:Seeds / Q000737:chemistry; D031957:Ziziphus / Q000737:chemistry*
chemical_list: C000617229:6''-O-feruloyl-6'''-p-hydroxybenzoylspinosin; C000617227:6''-O-feruloylspinosin; D000893:Anti-Inflammatory Agents; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D005419:Flavonoids; D005960:Glucosides
keywords: C-glucosyl flavonoids; COX inhibiting activity; Rhamnaceae; Ziziphus jujube