title: Intestinal Transplant Inflammation: the Third Inflammatory Bowel Disease.
abstract: Intestinal transplantation is the most immunologically complex of all abdominal organ transplants. Understanding the role both humoral and innate and adaptive cellular immunity play in intestinal transplantation is critical to improving outcomes and increasing indications for patients suffering from intestinal failure. Recent findings highlighting the impact of donor-specific antibodies on intestinal allografts, the role of NOD2 as a key regulator of intestinal immunity, the protective effects of innate lymphoid cells, and the role of Th17 in acute cellular rejection are reviewed here.
authors.affiliation: MedStar Georgetown Transplant Institute, 2PHC, Georgetown University Hospital, 3800 Reservoir Road NW, Washington, DC, 20007, USA. akroemer@me.com.
authors.forename: Alexander
authors.initials: A
authors.lastname: Kroemer
authors.affiliation: MedStar Georgetown Transplant Institute, 2PHC, Georgetown University Hospital, 3800 Reservoir Road NW, Washington, DC, 20007, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Cosentino
authors.affiliation: MedStar Georgetown Transplant Institute, 2PHC, Georgetown University Hospital, 3800 Reservoir Road NW, Washington, DC, 20007, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Kaiser
authors.affiliation: MedStar Georgetown Transplant Institute, 2PHC, Georgetown University Hospital, 3800 Reservoir Road NW, Washington, DC, 20007, USA.
authors.forename: Cal S
authors.initials: CS
authors.lastname: Matsumoto
authors.affiliation: MedStar Georgetown Transplant Institute, 2PHC, Georgetown University Hospital, 3800 Reservoir Road NW, Washington, DC, 20007, USA.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Fishbein
mesh_terms: D006084:Graft Rejection / Q000276:immunology; D006801:Humans; D018928:Immunity, Mucosal; D015212:Inflammatory Bowel Diseases / Q000209:etiology* / Q000276:immunology; D007413:Intestinal Mucosa / Q000276:immunology; D007422:Intestines / Q000637:transplantation*; D053473:Nod2 Signaling Adaptor Protein / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology
chemical_list: C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein
keywords: Antimicrobial peptides; Donor-specific antibodies; Innate lymphoid cells; Intestinal transplantation; NOD2; Th17 cells