title: An Efficient Synthesis of 2-Substituted Benzimidazoles via Photocatalytic Condensation of o-Phenylenediamines and Aldehydes.
abstract: A photocatalytic method has been developed for the efficient synthesis of functionalized benzimidazoles. This protocol involves photocatalytic condensation of o-phenylenediamines with various aldehydes using the Rose Bengal as photocatalyst. The method was found to be general and was successfully employed for accessing pharmaceutically important benzimidazoles by the condensation of aromatic, heteroaromatic and aliphatic aldehydes with o-phenylenediamines, in good-to-excellent yields. Notably, the method was found to be effective for the condensation of less reactive heterocyclic aldehydes with o-phenylenediamines.
authors.affiliation: Academy of Scientific and Innovative Research (AcSIR) , New Delhi-110025, India.|Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology , Hyderabad-500007, India.
authors.forename: Jeshma
authors.initials: J
authors.lastname: Kovvuri
authors.affiliation: Academy of Scientific and Innovative Research (AcSIR) , New Delhi-110025, India.|Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology , Hyderabad-500007, India.
authors.forename: Burri
authors.initials: B
authors.lastname: Nagaraju
authors.affiliation: Academy of Scientific and Innovative Research (AcSIR) , New Delhi-110025, India.|Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology , Hyderabad-500007, India.|Catalytic Chemistry Chair, Chemistry Department, College of Science, King Saud University , Riyadh 11451, Saudi Arabia.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Kamal
authors.affiliation: Academy of Scientific and Innovative Research (AcSIR) , New Delhi-110025, India.|Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology , Hyderabad-500007, India.
authors.forename: Ajay K
authors.initials: AK
authors.lastname: Srivastava
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D001562:Benzimidazoles / Q000138:chemical synthesis*; D002384:Catalysis; D008027:Light; D010655:Phenylenediamines / Q000737:chemistry*; D012997:Solvents
chemical_list: D000447:Aldehydes; D001562:Benzimidazoles; D010655:Phenylenediamines; D012997:Solvents; C034193:1,2-diaminobenzene
keywords: Rose Bengal; benzimidazole; o-phenylenediamine; photocatalytic condensation