title: Revisiting the Immunoglobulin Intramolecular Signaling Hypothesis.
abstract: A generation ago, the immunoglobulin intramolecular signaling, or allosteric, hypothesis was abandoned in favor of the associative hypothesis, which posited that Fc receptor crosslinking produced the increased affinity of antigen-antibody complexes. This essay argues that there is sufficient evidence to resuscitate the allosteric hypothesis, at least for some antibodies.
authors.affiliation: Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Anthony
authors.initials: A
authors.lastname: Bowen
authors.affiliation: Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. Electronic address: acasade1@jhu.edu.
authors.forename: Arturo
authors.initials: A
authors.lastname: Casadevall
mesh_terms: D000494:Allosteric Regulation; D000818:Animals; D000915:Antibody Affinity; D000936:Antigen-Antibody Complex / Q000378:metabolism; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism*; D018448:Models, Immunological; D020239:Receptor Cross-Talk; D011961:Receptors, Fc / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D000936:Antigen-Antibody Complex; D007136:Immunoglobulins; D011961:Receptors, Fc
keywords: allosteric model; antibody; associative model; immunoglobulin; intramolecular signaling