title: The cortical surface correlates of clinical manifestations in the mid-stage sporadic Parkinson's disease.
abstract: The alteration of pathological cortical surface may lead to the corresponding clinical manifestations of sporadic Parkinson's disease (sPD). Therefore, we investigated the correlates of cortical surface and clinical manifestations in the mid-stage sPD. Sixty seven mid-stage sPD patients and thirty five matched controls were performed the corticometry of magnetic resonance imaging (MRI) and the assessment of clinical manifestations including the demographic and disease-related characteristics, and underwent the final analysis of the correlates between cortical surface and clinical manifestations. The result revealed a significant correlation between CDT and Frontal-Sup-Orb-L, Frontal-Sup-Medial-L, Frontal-Mid-Orb-L and Rectus-L; SVFT and Frontal-Mid-L and Frontal-Inf-Tri-L; DF and Frontal-Sup-R, Frontal-Mid-R and Frontal-Sup-Medial-R; Webster and Occipital-Mid-R, Angular-R, Temporal-Sup-R and Temporal-Mid-R respectively in the mid-stage sPD patients. Our data suggested that the alterations of cortical surface in the left Frontal-Sup-Orb, Sup-Medial, Mid-Orb, Mid, Inf-Tri and Rectus, the right Frontal-Sup, Mid, Sup-Medial, and Occipital-Mid, Angular, Temporal-Sup and Temporal-Mid were the pathological base of some clinical manifestations including the cognitive impairment, the space structure, memory, attention, the abstract thinking, design, layout, utilization, digital, calculation, the time and spatial orientation concept, the operation sequence recognition and the partial motor dysfunctions in the mid-stage sPD, and that the dysfunctions of these brain regions contributed by the cortical surface lesion were closely correlated with some clinical manifestations of mid-stage sPD.
authors.affiliation: Department of Neurology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China. Electronic address: 921474135@qq.com.
authors.forename: Xia
authors.initials: X
authors.lastname: Deng
authors.affiliation: Department of Neurology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China. Electronic address: fishmonger@126.com.
authors.forename: Fang-Jun
authors.initials: FJ
authors.lastname: Li
authors.affiliation: Department of Neurology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China. Electronic address: 15279117628@163.com.
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Tang
authors.affiliation: Department of Neurology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China; Department of Biochemistry and Molecular Biology, College of Basic Medical Science, Nanchang University, Nanchang 330006, Jiangxi, China. Electronic address: zhangjie2006@aliyun.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Neurology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China. Electronic address: 812050896@qq.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Department of Neurology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China. Electronic address: 1759044167@qq.com.
authors.forename: Mei-Hong
authors.initials: MH
authors.lastname: Zhou
authors.affiliation: Graduate School of Southern Medical University, Guangzhou 510515, Guangdong Province, China; Department of Neurology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Neuroscience Institute, Guangzhou 510080, Guangdong Province, China. Electronic address: xiong715@126.com.
authors.forename: Xiong
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Radiology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China. Electronic address: honghan_gong@sina.com.
authors.forename: Hong-Han
authors.initials: HH
authors.lastname: Gong
authors.affiliation: Department of Radiology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China. Electronic address: xxz8785@sina.com.
authors.forename: Xiang-Zuo
authors.initials: XZ
authors.lastname: Xiao
authors.affiliation: Department of Neurology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China. Electronic address: xurenshi@ncu.edu.cn.
authors.forename: Ren-Shi
authors.initials: RS
authors.lastname: Xu
mesh_terms: D000368:Aged; D001931:Brain Mapping; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology* / Q000523:psychology
keywords: Clinical manifestation; Cortical surface; Disease-related characteristics; Functional magnetic resonance image; Sporadic Parkinson’s disease