title: Hyperspectral Imaging of Neoplastic Progression in a Mouse Model of Oral Carcinogenesis.
abstract: Hyperspectral imaging (HSI) is an emerging modality for medical applications and holds great potential for noninvasive early detection of cancer. It has been reported that early cancer detection can improve the survival and quality of life of head and neck cancer patients. In this paper, we explored the possibility of differentiating between premalignant lesions and healthy tongue tissue using hyperspectral imaging in a chemical induced oral cancer animal model. We proposed a novel classification algorithm for cancer detection using hyperspectral images. The method detected the dysplastic tissue with an average area under the curve (AUC) of 0.89. The hyperspectral imaging and classification technique may provide a new tool for oral cancer detection.
authors.affiliation: The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA.
authors.forename: Guolan
authors.initials: G
authors.lastname: Lu
authors.affiliation: Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA.
authors.forename: Xulei
authors.initials: X
authors.lastname: Qin
authors.affiliation: Department of Hematology and Medical Oncology, Emory University, Atlanta, GA.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Otolaryngology, Emory University School of Medicine, Atlanta, GA.
authors.forename: Susan
authors.initials: S
authors.lastname: Muller
authors.affiliation: Department of Otolaryngology, Emory University School of Medicine, Atlanta, GA.
authors.forename: Hongzheng
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Otolaryngology, Emory University School of Medicine, Atlanta, GA.
authors.forename: Amy
authors.initials: A
authors.lastname: Chen
authors.affiliation: Department of Hematology and Medical Oncology, Emory University, Atlanta, GA.
authors.forename: Zhuo Georgia
authors.initials: ZG
authors.lastname: Chen
authors.affiliation: The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA; Department of Mathematics & Computer Science, Emory University, Atlanta, GA; Winship Cancer Institute of Emory University, Atlanta, GA.
authors.forename: Baowei
authors.initials: B
authors.lastname: Fei
keywords: 4NQO-induced oral cancer; Hyperspectral imaging; early cancer detection; image classification; random forest; superpixel