title: Natural products against cancer angiogenesis.
abstract: The process of angiogenesis is quite well-known nowadays. Some medicines and extracts affecting this process are already used routinely in supporting the conventional treatment of many diseases that are considered angiogenic such as cancer. However, we must be aware that the area of currently used drugs of this type is much narrower than the theoretical possibilities existing in therapeutic angiogenesis. Plant substances are a large and diverse group of compounds that are found naturally in fruits, vegetables, spices, and medicinal plants. They also have different anticancer properties. The aim of this literature review article is to present the current state of knowledge concerning the molecular targets of tumor angiogenesis and the active substances (polyphenols, alkaloids, phytohormones, carbohydrates, and terpenes) derived from natural sources, whose activity against cancer angiogenesis has been confirmed.
authors.affiliation: Independent Research Team in Cancer Biology and Bioactive Compounds, Faculty of Medicine and Pharmacy, University Mohammed 1st, Oujda, Morocco. k.elbairi@ump.ac.ma.
authors.forename: El Bairi
authors.initials: EB
authors.lastname: Khalid
authors.affiliation: Department of Molecular Biology GEBRI, University of Sadat City, Sadat, Egypt.|Pathology Department, College of Medicine, Taif University, Taif, Saudi Arabia.
authors.forename: El-Meghawry El-Kenawy
authors.initials: EE
authors.lastname: Ayman
authors.affiliation: Department of Veterinary Clinical Diagnosis, Faculty of Veterinary Medicine, University Putra Malaysia, 43400, UPM Serdang, Selangor, Malaysia.|Department of Medical Laboratory Science, Komar University of Science and Technology, ChaqChaq, Qularasy, Sulaimani City, Kurdistan Region, Iraq.
authors.forename: Heshu
authors.initials: H
authors.lastname: Rahman
authors.affiliation: Laboratory of Genetics and Biotechnology (LGB), Faculty of Sciences, Mohammed 1st University (UMP), Oujda, Morocco.
authors.forename: Guaadaoui
authors.initials: G
authors.lastname: Abdelkarim
authors.affiliation: Quality Laboratory of Vegetable and Medicinal Materials, Department of Vegetable Crops and Medicinal Plants, University of Life Sciences in Lublin, Leszczyńskiego Street 58, 20-068, Lublin, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Najda
mesh_terms: D001688:Biological Products / Q000627:therapeutic use*; D018890:Chemoprevention; D042783:Endothelial Cells / Q000473:pathology; D006801:Humans; D009369:Neoplasms / Q000098:blood supply* / Q000188:drug therapy* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000188:drug therapy* / Q000473:pathology; D028321:Plant Preparations / Q000627:therapeutic use*; D010946:Plants, Medicinal
chemical_list: D001688:Biological Products; D028321:Plant Preparations
keywords: Angiogenesis; Cancer; Chemoprevention; Natural products; Targets