title: The effect of smoking on lung function: a clinical study of adult-onset asthma.
abstract: The aim of this study was to evaluate the effect of smoking on lung function decline in adult-onset asthma in a clinical, 12-year follow-up study.In the Seinäjoki Adult Asthma Study, 203 patients were followed for 12 years (1999-2013) after diagnosis of new-onset adult asthma. Patients were divided into two groups based on smoking history: <10 or ≥10 pack-years. Spirometry evaluation points were: 1) baseline, 2) the maximum lung function during the first 2.5 years after diagnosis (Max0-2.5) and 3) after 12 years of follow-up.Between Max0-2.5and follow-up, the median annual decline in absolute forced expiratory volume in 1 s (FEV1) was 36 mL in the group of patients with <10 pack-years of smoking and 54 mL in those with smoking history ≥10 pack-years (p=0.003). The annual declines in FEV1% pred (p=0.006), forced vital capacity (FVC) (p=0.035) and FEV1/FVC (p=0.045) were also accelerated in the group of patients with ≥10 pack-years smoked. In multivariate regression analysis, smoking history ≥10 pack-years became a significant predictor of accelerated decline in FEV1Among patients with clinically defined adult-onset asthma, smoking history ≥10 pack-years is associated with accelerated loss of lung function.
authors.affiliation: Dept of Respiratory Medicine, Seinäjoki Central Hospital, Seinäjoki, Finland minna.tommola@epshp.fi.
authors.forename: Minna
authors.initials: M
authors.lastname: Tommola
authors.affiliation: Dept of Respiratory Medicine, Seinäjoki Central Hospital, Seinäjoki, Finland.
authors.forename: Pinja
authors.initials: P
authors.lastname: Ilmarinen
authors.affiliation: Dept of Respiratory Medicine, Seinäjoki Central Hospital, Seinäjoki, Finland.
authors.forename: Leena E
authors.initials: LE
authors.lastname: Tuomisto
authors.affiliation: Dept of Clinical Physiology, Seinäjoki Central Hospital, Seinäjoki, Finland.
authors.forename: Jussi
authors.initials: J
authors.lastname: Haanpää
authors.affiliation: Police University College, Tampere, Finland.
authors.forename: Terhi
authors.initials: T
authors.lastname: Kankaanranta
authors.affiliation: Dept of Laboratory Medicine and Medical Research Unit, Seinäjoki Central Hospital, Seinäjoki, Finland.
authors.forename: Onni
authors.initials: O
authors.lastname: Niemelä
authors.affiliation: Dept of Respiratory Medicine, Seinäjoki Central Hospital, Seinäjoki, Finland.|Dept of Respiratory Medicine, University of Tampere, Tampere, Finland.
authors.forename: Hannu
authors.initials: H
authors.lastname: Kankaanranta
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D001249:Asthma / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D005387:Finland; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010641:Phenotype; D012129:Respiratory Function Tests; D012907:Smoking; D013147:Spirometry; D016896:Treatment Outcome; D014797:Vital Capacity