title: Molecular identification of human enteroviruses associated with aseptic meningitis in Yunnan province, Southwest China.
abstract: Human enteroviruses (EVs) are the major causative agents of aseptic meningitis. In this study, a total of 524 children were admitted to the children Kunming hospital (continental China) for aseptic meningitis manifestations in 2009 and 2010. An EV infection was diagnosed in 85/524 children (16.2 %) and the viruses detected were assigned to 16 serotypes. Most serotypes belonged to the enterovirus B species. Echovirus 9 was predominant (24.7 %), followed by coxsackievirus B5 (23.5 %) and then echovirus 30 (16.5 %). Echovirus 9 was firstly identified as the predominant serotype in sporadic aseptic meningitis which occurred in Yunnan, Southwest China. This work indicates the need to perform large-scale surveillance to gain a better insight into the epidemiology of enteroviruses associated with aseptic meningitis in China.
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medical Sciences, and Peking Union Medical College (CAMS and PUMC), 935 Jiao Ling Road, Kunming, 650118 Yunnan Province People's Republic of China ; Yunnan Key Laboratory of Vaccine Research Development on Severe Infectious Disease, Kunming, 650118 People's Republic of China ; Xixi Hospital of Hangzhou, Hangzhou, 310023 People's Republic of China.
authors.forename: Yanju
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: School of Public Health, Kunming Medical University, 1168 West Chun Rong Road, Yuhua Avenue, Chenggong District, Kunming, 650500 Yunnan People's Republic of China.
authors.forename: Xi
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medical Sciences, and Peking Union Medical College (CAMS and PUMC), 935 Jiao Ling Road, Kunming, 650118 Yunnan Province People's Republic of China ; Yunnan Key Laboratory of Vaccine Research Development on Severe Infectious Disease, Kunming, 650118 People's Republic of China.
authors.forename: Jiansheng
authors.initials: J
authors.lastname: Liu
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medical Sciences, and Peking Union Medical College (CAMS and PUMC), 935 Jiao Ling Road, Kunming, 650118 Yunnan Province People's Republic of China ; Yunnan Key Laboratory of Vaccine Research Development on Severe Infectious Disease, Kunming, 650118 People's Republic of China.
authors.forename: Longhui
authors.initials: L
authors.lastname: Xia
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medical Sciences, and Peking Union Medical College (CAMS and PUMC), 935 Jiao Ling Road, Kunming, 650118 Yunnan Province People's Republic of China ; Yunnan Key Laboratory of Vaccine Research Development on Severe Infectious Disease, Kunming, 650118 People's Republic of China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Pan
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medical Sciences, and Peking Union Medical College (CAMS and PUMC), 935 Jiao Ling Road, Kunming, 650118 Yunnan Province People's Republic of China ; Yunnan Key Laboratory of Vaccine Research Development on Severe Infectious Disease, Kunming, 650118 People's Republic of China.
authors.forename: Junying
authors.initials: J
authors.lastname: Chen
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medical Sciences, and Peking Union Medical College (CAMS and PUMC), 935 Jiao Ling Road, Kunming, 650118 Yunnan Province People's Republic of China ; Yunnan Key Laboratory of Vaccine Research Development on Severe Infectious Disease, Kunming, 650118 People's Republic of China.
authors.forename: Na
authors.initials: N
authors.lastname: Luo
authors.affiliation: School of Public Health, Kunming Medical University, 1168 West Chun Rong Road, Yuhua Avenue, Chenggong District, Kunming, 650500 Yunnan People's Republic of China.
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Yin
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medical Sciences, and Peking Union Medical College (CAMS and PUMC), 935 Jiao Ling Road, Kunming, 650118 Yunnan Province People's Republic of China ; Yunnan Key Laboratory of Vaccine Research Development on Severe Infectious Disease, Kunming, 650118 People's Republic of China.
authors.forename: Shaohui
authors.initials: S
authors.lastname: Ma
keywords: Coxsackievirus B5; Echovirus 30; Echovirus 9; Genotyping; Phylogenetic analysis