title: Role of Histologic Inflammation in the Natural History of Ulcerative Colitis.
abstract: The goals of therapy for ulcerative colitis have moved from symptom improvement to mucosal healing, and finally histologic resolution. The natural history of histologic inflammation in ulcerative colitis progresses from initial cellular infiltration to architectural disruption and recovery on medical therapy. Many studies have linked histologic changes to clinical outcomes, providing prognostic value to histologic abnormalities. This review covers all these components.
authors.affiliation: Cleveland Clinic, 9500 Euclid Av, L-25, Cleveland, OH 44195, USA. Electronic address: patild@ccf.org.
authors.forename: Deepa T
authors.initials: DT
authors.lastname: Patil
authors.affiliation: Harvard Medical School, 330 Brookline Ave., Boston, MA 02215, USA.
authors.forename: Alan C
authors.initials: AC
authors.lastname: Moss
authors.affiliation: Gastrointestinal Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Robert D
authors.initials: RD
authors.lastname: Odze
mesh_terms: D003093:Colitis, Ulcerative / Q000473:pathology*; D018450:Disease Progression; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology*; D011379:Prognosis
keywords: Histology; Prognosis; Severity; Ulcerative colitis