title: Different Vancomycin Immunoassays Contribute to the Variability in Vancomycin Trough Measurements in Neonates.
abstract: Substantial interassay variability (up to 20%) has been described for vancomycin immunoassays in adults, but the impact of neonatal matrix is difficult to quantify because of blood volume constraints in neonates. However, we provide circumstantial evidence for a similar extent of variability. Using the same vancomycin dosing regimens and confirming similarity in clinical characteristics, vancomycin trough concentrations measured by PETINIA (2011-2012, n = 400) were 20% lower and the mean difference was 1.93 mg/L compared to COBAS (2012-2014, n = 352) measurements. The impact of vancomycin immunoassays in neonatal matrix was hereby suggested, supporting a switch to more advanced techniques (LC-MS/MS).
authors.affiliation: Institute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, 11000 Belgrade, Serbia; Division of Pediatric Pharmacology and Pharmacometrics, University of Basel Children's Hospital, 4056 Basel, Switzerland.
authors.forename: Janko
authors.identifier: 0000-0002-8464-4924
authors.initials: J
authors.lastname: Samardzic
authors.affiliation: Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium; Neonatal Intensive Care Unit, University Hospitals Leuven, 3000 Leuven, Belgium.
authors.forename: Anne
authors.initials: A
authors.lastname: Smits
authors.affiliation: Clinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven and Pharmacy Department, University Hospitals Leuven, 3000 Leuven, Belgium.
authors.forename: Isabel
authors.initials: I
authors.lastname: Spriet
authors.affiliation: Medical Faculty, University of Belgrade, 11000 Belgrade, Serbia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Soldatovic
authors.affiliation: Division of Pediatric Pharmacology and Pharmacometrics, University of Basel Children's Hospital, 4056 Basel, Switzerland.
authors.forename: Andrew
authors.initials: A
authors.lastname: Atkinson
authors.affiliation: Institute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, 11000 Belgrade, Serbia; Clinical Pharmacology Unit, University Children's Hospital, 11000 Belgrade, Serbia.
authors.forename: Milica
authors.initials: M
authors.lastname: Bajcetic
authors.affiliation: Division of Pediatric Pharmacology and Pharmacometrics, University of Basel Children's Hospital, 4056 Basel, Switzerland; Division of Pediatric Clinical Pharmacology, Children's National Medical Center, Washington, DC 20010, USA; Intensive Care and Department of Pediatric Surgery, Erasmus MC Sophia Children's Hospital, 3000 CB Rotterdam, Netherlands.
authors.forename: John N
authors.initials: JN
authors.lastname: Van Den Anker
authors.affiliation: Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium; Intensive Care and Department of Pediatric Surgery, Erasmus MC Sophia Children's Hospital, 3000 CB Rotterdam, Netherlands.
authors.forename: Karel
authors.initials: K
authors.lastname: Allegaert
mesh_terms: D055499:Catheter-Related Infections / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005865:Gestational Age; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D007231:Infant, Newborn; D011247:Pregnancy; D018805:Sepsis / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D014640:Vancomycin / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood
chemical_list: D014640:Vancomycin