title: Effect of Dipyridamole Injected for Myocardial Perfusion Imaging on Blood Glucose Concentration; A Preliminary Study.
abstract: BACKGROUND
  Dipyridamole inhibits adenosine reuptake and increases cyclic Adenosine Monophosphate (cAMP) levels in platelets, erythrocytes and endothelial cells, all of which influence blood glucose. Acute hyperglycaemia reduces endothelium-dependent vasodilation and suppresses coronary microcirculation; which, in theory, can alter the outcome of a radionuclide scan.
  
  
  OBJECTIVE
  The present study was conducted with the aim to investigate the changes in blood glucose level of patients receiving dipyridamole for cardiac scan.
  
  
  METHODS
  A total of 293 patients (85 men and 208 women, age: 60.59±10.43 years) were included in the study. Fasting Blood Glucose (FBG) was measured before and 8 min after dipyridamole (0.568 mg/kg) injection during myocardial perfusion imaging. The data in different groups were analysed by paired t-test.
  
  
  RESULTS
  There was not a significant difference between first (106.89 ± 19.21mg/dL) and second (107.98 ± 17.57 mg/dL) FBG measurements (p= 0.293). However, when the patients were grouped based on the quartiles of first measurement, there was an increase in FBG following dipyridamole injection in the first quartile (mean difference: 7.15±21.27 mg/dL, p<0.01); in contrast, FBG levels showed a significant decrease after dipyridamole administration in the 4(th) quartile (mean difference: -9.53±18.20 mg/dL, p<0.001). The differences in 2(nd) and 3(rd) quartiles were negligible. The patients were divided into normal, ischemic and fixed lesions based on the outcome of scans, then the possible correlation of dipyridamole-induced FBG alteration and scan results were investigated. There were no significant difference between the FBG values before and after dipyridamole injection and the final outcome of scan.
  
  
  CONCLUSIONS
  The effects of dipyridamole on blood glucose highly depend on the initial blood glucose level.
authors.affiliation: Assistant Professor, Department of Nuclear Medicine, Faculty of Medicine, Imam Hossein Hospital, Shahroud University of Medical Sciences , Shahroud, Iran .
authors.forename: Amirreza
authors.initials: A
authors.lastname: Khorasanchi
authors.affiliation: Assistant Professor, Department of Nuclear Medicine, Faculty of Medicine, Imam Hossein Hospital, Shahroud University of Medical Sciences , Shahroud, Iran .
authors.forename: Mohsen
authors.initials: M
authors.lastname: Arabi
authors.affiliation: Assistant Professor, Department of Cardiology, Islamic Azad University Tehran Medical Branch, Tehran, Iran .
authors.forename: Alireza
authors.initials: A
authors.lastname: Akhavein
authors.affiliation: Assistant Professor, Department of Pharmacology, The Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences , Bushehr, Iran .
authors.forename: Mohammad
authors.initials: M
authors.lastname: Seyedabadi
authors.affiliation: Researcher, Department of Nuclear Medicine, Faculty of Medicine, Imam Hossein Hospital, Shahroud University of Medical Sciences , Shahroud, Iran .
authors.forename: Mansooreh
authors.initials: M
authors.lastname: Eftekhari
authors.affiliation: Assistant Professor, Department of Nuclear Medicine, Golestan Research Center of Gastroenterology and Hepatology (GRCGH), Golestan University of Medical Sciences (GUOMS) , Gorgan, Iran .
authors.forename: Hamid
authors.initials: H
authors.lastname: Javadi
authors.affiliation: Professor, Department of Endocrinology, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences , Bushehr, Iran .
authors.forename: Iraj
authors.initials: I
authors.lastname: Nabipour
authors.affiliation: Professor, Department of Molecular Imaging and Radionuclide Therapy (MIRT), The Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences , Bushehr, Iran .
authors.forename: Majid
authors.initials: M
authors.lastname: Assadi
keywords: Blood glucose; Dipyridamole; Myocardial perfusion imaging