title: Postoperative radiation therapy of pT2-3N0M0 esophageal carcinoma-a review.
abstract: Esophageal cancer is one of the most malignant gastrointestinal cancers worldwide. Despite advances in surgical technique, 5-year survival in pathologic stage T2-3N0M0 esophageal squamous cell carcinoma patients who are treated with surgery alone is still poor. The addition of adjuvant radiotherapy may confer a benefit for these patients. However, not all patients could get a benefit from radiotherapy and patients with esophageal squamous cell carcinoma receiving radiotherapy seem to have a disparity in treatment response. Thus, identifying effective prognostic indicator to complement current clinical staging approaches is extremely important. Those prognostic factors could give rise to a novel prognostic stratification system, which serve as criteria for selecting patients for adjuvant therapy. Consequently, it may help to define the subgroups who are more likely to benefit from postoperative radiation therapy.
authors.affiliation: School of Medical and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong, China.|Department of Radiation Oncology and Radiology, Shandong Cancer Hospital Affiliated to Shandong University, Jiyan Road 440, Jinan, Shandong Province, 250117, China.
authors.forename: Yijun
authors.initials: Y
authors.lastname: Luo
authors.affiliation: School of Medical and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong, China.|Department of Radiation Oncology and Radiology, Shandong Cancer Hospital Affiliated to Shandong University, Jiyan Road 440, Jinan, Shandong Province, 250117, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Radiation Oncology and Radiology, Shandong Cancer Hospital Affiliated to Shandong University, Jiyan Road 440, Jinan, Shandong Province, 250117, China.
authors.forename: Jinming
authors.initials: J
authors.lastname: Yu
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Radiation Oncology and Radiology, Shandong Cancer Hospital Affiliated to Shandong University, Jiyan Road 440, Jinan, Shandong Province, 250117, China. Sdlmh2014@163.com.
authors.forename: Minghuan
authors.initials: M
authors.lastname: Li
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery*; D003131:Combined Modality Therapy / Q000379:methods; D004938:Esophageal Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery*; D000077277:Esophageal Squamous Cell Carcinoma; D006801:Humans; D009367:Neoplasm Staging; D011184:Postoperative Period; D011379:Prognosis; D018714:Radiotherapy, Adjuvant / Q000379:methods*; D015996:Survival Rate
keywords: Esophageal squamous cell carcinoma; Postoperative; Prognosis factors; Prognostic assessment; Radiation therapy; Therapeutic evaluation