title: Predictive and Prognostic Value of sPRR in Patients with Primary Epithelial Ovarian Cancer.
abstract: Aim. The purpose of the present study was to analyze the predictive and prognostic role of soluble (pro)renin receptor (sPRR) as a biomarker for clinicopathological outcome in patients with primary epithelial ovarian cancer (EOC). As part of the renin-angiotensin system (RAS) whose activity is known to increase in ovarian cancer patients, the relation of sPRR and ovarian cancer should be further investigated.Patients and Methods. In this study 197 patients with primary EOC in our institution from 2000 to 2011 were included. sPRR was determined by enzyme-linked immunosorbent assay (ELISA) in preoperative taken blood sera. Associations with clinicopathological outcome were analyzed and serum levels of sPRR in patients have been compared to those in healthy specimen. Kaplan-Meier and logistic/Cox regression assessed the impact of the markers on progression-free survival (PFS) and overall survival (OS).Results. There have been no correlations proved of sPRR levels with neither clinicopathological factors nor prognostic data. Also the distribution of sPRR in patients and controls was normal.Conclusion. sPRR seems to have no predictive, prognostic, or diagnostic value in EOC. As several factors of the RAS which might indicate cancer events have been shown, sPRR seems not to be affected.
authors.affiliation: Department of Gynecology, Campus Virchow Klinikum, Charité Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Katrin
authors.identifier: 0000-0002-6772-2601
authors.initials: K
authors.lastname: Kreienbring
authors.affiliation: Department of Gynecology, Campus Virchow Klinikum, Charité Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Annika
authors.initials: A
authors.lastname: Franz
authors.affiliation: Department of Gynecology, Campus Virchow Klinikum, Charité Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Rolf
authors.initials: R
authors.lastname: Richter
authors.affiliation: Department of Nephrology and Intensive Care Medicine, Charité Universtätsmedizin Berlin, Berlin, Germany.
authors.forename: Duska
authors.initials: D
authors.lastname: Dragun
authors.affiliation: CellTrend, Luckenwalde, Germany.
authors.forename: Harald
authors.initials: H
authors.lastname: Heidecke
authors.affiliation: Experimental and Clinical Research Center, Berlin, Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Dechend
authors.affiliation: Experimental and Clinical Research Center, Berlin, Germany.
authors.forename: Dominik N
authors.initials: DN
authors.lastname: Muller
authors.affiliation: Department of Gynecology, Campus Virchow Klinikum, Charité Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Jalid
authors.initials: J
authors.lastname: Sehouli
authors.affiliation: Department of Gynecology, Campus Virchow Klinikum, Charité Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Elena I
authors.initials: EI
authors.lastname: Braicu