title: Nondeterministic self-assembly with asymmetric interactions.
abstract: We investigate general properties of nondeterministic self-assembly with asymmetric interactions, using a computational model and DNA tile assembly experiments. By contrasting symmetric and asymmetric interactions we show that the latter can lead to self-limiting cluster growth. Furthermore, by adjusting the relative abundance of self-assembly particles in a two-particle mixture, we are able to tune the final sizes of these clusters. We show that this is a fundamental property of asymmetric interactions, which has potential applications in bioengineering, and provides insights into the study of diseases caused by protein aggregation.
authors.affiliation: Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, CB3 0HE Cambridge, United Kingdom.
authors.forename: S
authors.initials: S
authors.lastname: Tesoro
authors.affiliation: Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, CB3 0HE Cambridge, United Kingdom.
authors.forename: K
authors.initials: K
authors.lastname: Göpfrich
authors.affiliation: Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, CB3 0HE Cambridge, United Kingdom.
authors.forename: T
authors.initials: T
authors.lastname: Kartanas
authors.affiliation: Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, CB3 0HE Cambridge, United Kingdom.
authors.forename: U F
authors.initials: UF
authors.lastname: Keyser
authors.affiliation: Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, CB3 0HE Cambridge, United Kingdom.
authors.forename: S E
authors.initials: SE
authors.lastname: Ahnert