title: [Immunological mechanism of wheezing attack in children with cytomegalovirus infection].
abstract: OBJECTIVE
  To study the possible immunological mechanism of wheezing attack in children with cytomegalovirus (CMV) infection.
  
  
  METHODS
  A total of 25 under-5-year-old children with wheezing following CMV infection were enrolled. The expression of serum regulatory T cells (Treg)/T helper 17 (Th17) cytokines interleukin (IL)-10, IL-6, and IL-17, and peripheral blood lymphocyte subsets were determined. Twenty age-matched healthy children were selected as the control group.
  
  
  RESULTS
  The wheezing group had a significantly reduced serum IL-10 level, significantly increased IL-6 and IL-17 levels, significantly reduced levels of natural killer cells, and significantly increased levels of CD8+ T cells and CD19+ B cells, as compared with the control group.
  
  
  CONCLUSIONS
  Wheezing children with CMV infection have Treg/Th17 imbalance and cellular immune dysfunction, which may be an important immunological mechanism of the development of wheezing in children after CMV infection.
authors.affiliation: School of Medicine, Nanchang University, Nanchang 330006, China. zxhjxmc@163.com.
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Zhu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Chen
authors.forename: Qiu-Gen
authors.initials: QG
authors.lastname: Li
authors.forename: Lan
authors.initials: L
authors.lastname: Li
authors.forename: Jiang-Wei
authors.initials: JW
authors.lastname: Ke
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Liu
authors.forename: Fei
authors.initials: F
authors.lastname: Ran
mesh_terms: D002675:Child, Preschool; D016207:Cytokines / Q000097:blood; D003586:Cytomegalovirus Infections / Q000276:immunology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012135:Respiratory Sounds / Q000209:etiology / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology
chemical_list: D016207:Cytokines