title: Exome Variant Analysis of Chronic Periodontitis in 2 Large Cohort Studies.
abstract: Periodontitis is characterized by inflammation of the gingival tissue. The main risk factors are socioeconomic factors, sex, age, smoking, and diabetes, but periodontal disease has also a genetic background. Previous genome-wide association studies failed to reveal genome-wide significant associations of single common single-nucleotide polymorphisms with chronic periodontitis. Using the Illumina ExomeChip data of 6,576 participants of the German population-based cohort studies Study of Health in Pomerania (SHIP) and SHIP-Trend, the authors performed single variant and also gene-based association studies of rare and common exonic variations on different periodontal case definitions. Although our study comprised the largest sample size to date to assess genetic predisposition for chronic periodontitis, the authors found no significant association. This study emphasizes that for chronic periodontitis, large sample sizes will be necessary to find genetic associations, even when examining rare genetic variants.
authors.affiliation: 1 Unit of Periodontology, Department of Restorative Dentistry, Periodontology and Endodontology, Pedodontics and Preventive Dentistry, University Medicine Greifswald, Greifswald, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Kasbohm
authors.affiliation: 1 Unit of Periodontology, Department of Restorative Dentistry, Periodontology and Endodontology, Pedodontics and Preventive Dentistry, University Medicine Greifswald, Greifswald, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Holtfreter
authors.affiliation: 2 Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Völker
authors.affiliation: 3 Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Petersmann
authors.affiliation: 4 Department of Prosthodontics, Gerostomatology and Biomaterials, Center for Oral Health, University Medicine Greifswald, Greifswald, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Samietz
authors.affiliation: 4 Department of Prosthodontics, Gerostomatology and Biomaterials, Center for Oral Health, University Medicine Greifswald, Greifswald, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Biffar
authors.affiliation: 5 Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Völzke
authors.affiliation: 1 Unit of Periodontology, Department of Restorative Dentistry, Periodontology and Endodontology, Pedodontics and Preventive Dentistry, University Medicine Greifswald, Greifswald, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Meisel
authors.affiliation: 2 Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Kacprowski
authors.affiliation: 2 Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Homuth
authors.affiliation: 1 Unit of Periodontology, Department of Restorative Dentistry, Periodontology and Endodontology, Pedodontics and Preventive Dentistry, University Medicine Greifswald, Greifswald, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Kocher
authors.affiliation: 5 Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Teumer
mesh_terms: D055113:Chronic Periodontitis / Q000235:genetics*; D059472:Exome / Q000235:genetics*; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D055106:Genome-Wide Association Study; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
chemical_list: D005819:Genetic Markers
keywords: genetic association studies; genetic markers; genetic variation; medical genetics; periodontal attachment loss; periodontal diseases