title: Association of Salivary Osteopontin Levels with Glycaemic Status and Microalbuminuria - in Patients with Type 2 Diabetes Mellitus.
abstract: BACKGROUND
  The monitoring of glycaemic status in patients with T2DM is mainly through blood tests (Fasting plasma glucose and HbA1c), which are invasive and involves painful pricks. This leads to poor patient compliance and soon could lead to various micro and macro vascular complications, which hamper the quality of life. There are no sensitive and specific markers to predict these complications at the earliest. Sialochemistry has recently gained attention for monitoring chronic diseases. Osteopontin is a phospho-glycoprotein molecule, elevated in many inflammatory conditions.
  
  
  OBJECTIVE
  The aim of the study was to evaluate the role of serum and salivary osteopontin in Type 2 Diabetes mellitus (T2DM).
  
  
  METHODS
  In this case-control study, we recruited 33 cases of T2DM and 31 age and gender matched healthy controls. Body Mass Index (BMI), Waist/Hip Ratio (WHR), Waist Circumference (WC) and blood pressure was recorded. Fasting Plasma Glucose (FPG), salivary glucose, HbA1c, microalbuminuria, systolic BP, serum and salivary osteopontin levels were estimated.
  
  
  RESULTS
  FPG, salivary glucose, HbA1c, microalbuminuria, systolic BP, BMI, waist / hip ratio serum and salivary osteopontin levels were significantly high in T2DM cases compared to control subjects. Serum and salivary osteopontin levels were significantly correlated with HbA1c and microalbuminuria in T2DM cases.
  
  
  CONCLUSIONS
  Serum and salivary osteopontin levels are significantly elevated in subjects with T2DM and are associated with glycaemic control and microalbuminuria.
authors.affiliation: Associate Professor, Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute , Pondicherry, India .
authors.forename: Niranjan
authors.initials: N
authors.lastname: Gopal
authors.affiliation: Assistant Professor, Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute , Pondicherry, India .
authors.forename: Reeta
authors.initials: R
authors.lastname: Rajagambeeram
authors.affiliation: Student, Indira Gandhi Institute of Dental Sciences (IGIDS) , SBV (NAAC 'A' Grade), Pillaiyarkuppam, Pondicherry, India .
authors.forename: Shruthi
authors.initials: S
authors.lastname: Venkatkumar
authors.affiliation: Tutor, Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute , Pondicherry, India .
authors.forename: Mohana Valli
authors.initials: MV
authors.lastname: Vijayan
authors.affiliation: Assistant Professor, Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute , Pondicherry, India .
authors.forename: Sathish Babu
authors.initials: SB
authors.lastname: Murugaiyan
authors.affiliation: Student, M Pharm in Pharmacology, Mother Theresa Post Graduate and Research Institute of Health sciences , Indira Nagar, Gorimedu, Puducherry, India .
authors.forename: Shyam Prakash
authors.initials: SP
authors.lastname: Gopal
authors.affiliation: Tutor, Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute , Pondicherry, India .
authors.forename: Sathiya
authors.initials: S
authors.lastname: Ramsamy
authors.affiliation: Assistant Professor, Department of Biochemistry, Chennai Medical College , Hospital & Research Centre, Trichy- Tamil Nadu, India .
authors.forename: Velayutharaj
authors.initials: V
authors.lastname: Alwar
keywords: Diabetic nephropathy; Fasting Plasma Glucose; HbA1c