title: A Case Report of Penile Infection Caused by Fluconazole- and Terbinafine-Resistant Candida albicans.
abstract: Candida albicans is the most common pathogen that causes balanoposthitis. It often causes recurrence of symptoms probably due to its antifungal resistance. A significant number of balanitis Candida albicans isolates are resistant to azole and terbinafine antifungal agents in vitro. However, balanoposthitis caused by fluconazole- and terbinafine-resistant Candida albicans has rarely been reported. Here, we describe a case of a recurrent penile infection caused by fluconazole- and terbinafine-resistant Candida albicans, as well as the treatments administered to this patient. The isolate from the patient was tested for drug susceptibility in vitro. It was sensitive to itraconazole, voriconazole, clotrimazole and amphotericin B, but not to terbinafine and fluconazole. Thus, oral itraconazole was administrated to this patient with resistant Candida albicans penile infection. The symptoms were improved, and mycological examination result was negative. Follow-up treatment of this patient for 3 months showed no recurrence.
authors.affiliation: Department of Dermatology and Venerology, The 3rd Affiliated Hospital of Southern Medical University, 183 West Zhongshan Rd, Guangzhou, 510630, China. huyongxuan2003@163.com.
authors.forename: Yongxuan
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Dermatology and Venerology, The 3rd Affiliated Hospital of Southern Medical University, 183 West Zhongshan Rd, Guangzhou, 510630, China.
authors.forename: Yanqing
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Dermatology and Venerology, The 3rd Affiliated Hospital of Southern Medical University, 183 West Zhongshan Rd, Guangzhou, 510630, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Dermatology and Venerology, The 3rd Affiliated Hospital of Southern Medical University, 183 West Zhongshan Rd, Guangzhou, 510630, China.
authors.forename: Shiyun
authors.initials: S
authors.lastname: Huang
authors.affiliation: Department of Dermatology and Venerology, The 3rd Affiliated Hospital of Southern Medical University, 183 West Zhongshan Rd, Guangzhou, 510630, China.
authors.forename: Kangxing
authors.initials: K
authors.lastname: Liu
authors.affiliation: Department of Dermatology and Venerology, The 3rd Affiliated Hospital of Southern Medical University, 183 West Zhongshan Rd, Guangzhou, 510630, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Han
authors.affiliation: Department of Dermatology and Venerology, The 3rd Affiliated Hospital of Southern Medical University, 183 West Zhongshan Rd, Guangzhou, 510630, China.
authors.forename: Zuhao
authors.initials: Z
authors.lastname: Mao
authors.affiliation: Department of Dermatology and Venerology, The 3rd Affiliated Hospital of Southern Medical University, 183 West Zhongshan Rd, Guangzhou, 510630, China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Dermatology and Venerology, The 3rd Affiliated Hospital of Southern Medical University, 183 West Zhongshan Rd, Guangzhou, 510630, China. zxy1962@163.com.
authors.forename: Xianyi
authors.initials: X
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002176:Candida albicans / Q000187:drug effects* / Q000302:isolation & purification; D002178:Candidiasis, Chronic Mucocutaneous / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D025141:Drug Resistance, Fungal; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D008826:Microbial Sensitivity Tests; D008828:Microbiological Techniques; D025202:Molecular Diagnostic Techniques; D009281:Naphthalenes / Q000494:pharmacology*; D010409:Penile Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D012008:Recurrence; D000077291:Terbinafine; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D017964:Itraconazole; D015725:Fluconazole; D000077291:Terbinafine
keywords: Candida albicans; Fluconazole; Itraconazole; Penile infection; Resistance; Terbinafine