title: Anticancer Activities of Medicinal Plants: Modulation of p53 Expression and Induction of Apoptosis.
abstract: For the treatment of several types of cancers, tumors and malignancies, scientists are investigating natural sources to discover novel therapeutic agents from medicinal plants having diverse anticancer properties. Research on natural products is being conducted to identify unexplored phytochemical constituents that have been proven to have diverse pharmacological activities. Several medicinal plants have been reported to regulate the progression of different types of cancers, tumors, and malignancies. In this article, we briefly summarize the recent progress in exploring the anticancer properties of various medicinal plants reported to modulate the expression of p53 and the induction of apoptosis. These plants provide a rich source of chemo-protective agents that can ultimately be used to manage cancer progression.
authors.affiliation: Pharmaceutical Resources Botany Laboratory, Department of Pharmacognosy, College of Pharmacy, Chung-ang University, Seoul, Republic of Korea; Department of Pharmaceutical Chemistry, Government College University Faisalabad, Pakistan.
authors.forename: Amna
authors.initials: A
authors.lastname: Parveen
authors.affiliation: Department of Pharmaceutical Chemistry, Government College University Faisalabad, Pakistan.
authors.forename: Muhammad Sajid Hamid
authors.initials: MS
authors.lastname: Akash
authors.affiliation: Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China; Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan.
authors.forename: Kanwal
authors.initials: K
authors.lastname: Rehman
authors.affiliation: Pharmaceutical Resources Botany Laboratory, Department of Pharmacognosy, College of Pharmacy, Chung-ang University, Seoul, Republic of Korea.
authors.forename: Whang Wan
authors.initials: WW
authors.lastname: Kyunn
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D008517:Phytotherapy; D010946:Plants, Medicinal; D016159:Tumor Suppressor Protein p53 / Q000187:drug effects* / Q000235:genetics
chemical_list: D016159:Tumor Suppressor Protein p53