title: Catalytic Multisite-Selective Acetoxylation Reactions at sp2vs sp3C-H Bonds in Cyclic Olefins.
abstract: The first Pd-catalyzed multisite-selective acetoxylation reactions are disclosed at an unactivated alkene sp2C-H bond versus secondary allylic sp3C-H bond in cyclic olefins via the modulation of directing groups. The different directing groups overcome the key challenge in differentiating C-H bonds and provide a new controlling approach for site-specific C-H activation. A wide variety of substrates are readily acetoxylated under operationally simple conditions. Mechanistic studies suggest that different Pd (IV) intermediates were involved in the multisite-selective acetoxylation reactions.
authors.affiliation: School of Pharmaceutical Sciences and Innovative Drug Research Centre, Chongqing University , 55 Daxuecheng South Road, Shapingba, Chongqing 401331, P.R. China.
authors.forename: Zhong-Lin
authors.initials: ZL
authors.lastname: Zang
authors.affiliation: School of Pharmaceutical Sciences and Innovative Drug Research Centre, Chongqing University , 55 Daxuecheng South Road, Shapingba, Chongqing 401331, P.R. China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhao
authors.affiliation: School of Pharmaceutical Sciences and Innovative Drug Research Centre, Chongqing University , 55 Daxuecheng South Road, Shapingba, Chongqing 401331, P.R. China.
authors.forename: Shuklachary
authors.initials: S
authors.lastname: Karnakanti
authors.affiliation: School of Pharmaceutical Sciences and Innovative Drug Research Centre, Chongqing University , 55 Daxuecheng South Road, Shapingba, Chongqing 401331, P.R. China.
authors.forename: Cheng-Lin
authors.initials: CL
authors.lastname: Liu
authors.affiliation: School of Pharmaceutical Sciences and Innovative Drug Research Centre, Chongqing University , 55 Daxuecheng South Road, Shapingba, Chongqing 401331, P.R. China.
authors.forename: Pan-Lin
authors.initials: PL
authors.lastname: Shao
authors.affiliation: School of Pharmaceutical Sciences and Innovative Drug Research Centre, Chongqing University , 55 Daxuecheng South Road, Shapingba, Chongqing 401331, P.R. China.
authors.forename: Yun
authors.initials: Y
authors.lastname: He