title: Outcome of antiepileptic drug treatment of 1282 patients with epilepsy, their pharmacovigilance reports and concomitant medication on CNS in an East-Hungarian adult database.
abstract: OBJECTIVE
  The aim of this study was to determine the outcome of antiepileptic drug (AED) treatment based on seizure freedom, pharmacovigilance reports and effects of concomitant medication on the central nervous system (CNS) of adult epileptic patients registered in the East-Hungarian Epilepsy Database.
  
  
  METHODS
  Prospective cross-sectional database was compiled from outpatient files between 1992 and 2011.
  
  
  RESULTS
  The majority of 1282 treated patients were on monotherapy 894 patients (70%), 286 (22%) on bitherapy and 102 (8%) on polytherapy. Of all treated patients, seizure freedom was achieved by 603 (47%). Among the seizure free patients 464 (77%) were on monotherapy, 115 (19%) on bitherapy and only 24 (4%) on polytherapy. The overall rate of adverse drug reactions (ADRs) was 16.2%. From patients on AED, 279 (22%) took concomitant drugs acting on the CNS. In a logistic regression model, other CNS-related drugs and a number of prescribed antiepileptic drugs had a significant influence on the desired outcome of seizure freedom. On comparing the Proportional Reporting Ratio and 95%CI of older and newer AEDs, no significant superiority of newer AEDs was detected.
  
  
  CONCLUSIONS
  Careful drug selection for epileptic patients must be highlighted in order to improve outcome, reduce ADRs and improve patient compliance.
authors.affiliation: University of Debrecen, Faculty of Pharmacy, Department of Pharmaceutical Surveillance and Economy, Nagyerdei krt. 98., Debrecen, Hungary. Electronic address: lhorvath@med.unideb.hu.
authors.forename: László
authors.initials: L
authors.lastname: Horváth
authors.affiliation: University of Debrecen, Faculty of Medicine, Department of Neurology, Móricz Zs. krt. 22., Debrecen, Hungary. Electronic address: feketek@med.unideb.hu.
authors.forename: Klára
authors.initials: K
authors.lastname: Fekete
authors.affiliation: University of Debrecen, Faculty of Art, Institute of Political Science and Sociology, Egyetem tér 1., Debrecen, Hungary. Electronic address: marton.sandor@arts.unideb.hu.
authors.forename: Sándor
authors.initials: S
authors.lastname: Márton
authors.affiliation: University of Debrecen, Faculty of Medicine, Department of Neurology, Móricz Zs. krt. 22., Debrecen, Hungary. Electronic address: fekete@med.unideb.hu.
authors.forename: István
authors.initials: I
authors.lastname: Fekete
mesh_terms: D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000627:therapeutic use*; D002490:Central Nervous System / Q000187:drug effects*; D003430:Cross-Sectional Studies; D016208:Databases, Factual / Q000706:statistics & numerical data; D004827:Epilepsy / Q000188:drug therapy* / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D060735:Pharmacovigilance; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants
keywords: Adverse drug reaction; Antiepileptic drug treatment; Database; Epilepsy; Pharmacovigilance; Seizure freedom