title: Comparison of biological effects with albumin adducts of 4,4'-methylenediphenyl diisocyanate in workers.
abstract: Lung sensitization and asthma are the main health effects of 4,4'-methylenediphenyl diisocyanate (MDI). Albumin adducts (isocyanate-specific adducts) of MDI might be involved in the etiology of sensitization reactions. Albumin adducts of MDI were analyzed in sera of diisocyanate-exposed worker with and without diisocyanate occupational asthma (DA), as well as in exposed workers with and without diisocyanate-specific IgG antibodies. In DA-positive workers and IgG-positive workers, albumin adducts were significantly higher versus workers without DA and those who were specific IgG negative. The odds ratio to be DA-positive was 57 times larger for workers with adduct levels above 230 fmol/mg. The odds ratio to be IgG-positive was 10 times larger for workers with adduct levels above 113 fmol/mg. Therefore, albumin adducts appear to be a good predictor of the biological effects. The albumin-adduct levels in workers without biological effects were in the range of the adduct levels found in previous studies of healthy MDI-factory and construction site workers.
authors.affiliation: Institute of Environmental and Occupational Toxicology, Casella Postale 108, 6780, Airolo, Switzerland. gabriele.sabbioni@bluewin.ch.|Walther-Straub-Institut für Pharmakologie und Toxikologie, Ludwig-Maximilians-Universität München, 80336, München, Germany. gabriele.sabbioni@bluewin.ch.|Department of Environmental Health Sciences, School of Public Health and Tropical Medicine, Tulane University, 1440 Canal St., Suite 2100, New Orleans, LA, 70112, USA. gabriele.sabbioni@bluewin.ch.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Sabbioni
authors.affiliation: Department of Environmental Health Sciences, School of Public Health and Tropical Medicine, Tulane University, 1440 Canal St., Suite 2100, New Orleans, LA, 70112, USA.
authors.forename: Lakshiminiranjan Reddy
authors.initials: LR
authors.lastname: Vanimireddy
authors.affiliation: Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.
authors.forename: Zana L
authors.initials: ZL
authors.lastname: Lummus
authors.affiliation: Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.
authors.forename: David I
authors.initials: DI
authors.lastname: Bernstein
mesh_terms: D000906:Antibodies / Q000276:immunology; D059366:Asthma, Occupational / Q000097:blood / Q000139:chemically induced*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D017953:Isocyanates / Q000008:administration & dosage / Q000633:toxicity*; D016273:Occupational Exposure / Q000009:adverse effects*; D010865:Pilot Projects; D012709:Serum Albumin / Q000378:metabolism*; D001559:Benzhydryl Compounds
chemical_list: D000906:Antibodies; D007074:Immunoglobulin G; D017953:Isocyanates; D012709:Serum Albumin; C005969:4,4'-diphenylmethane diisocyanate; D001559:Benzhydryl Compounds
keywords: Albumin adducts; Biomonitoring; Isocyanates; Occupational asthma