title: Immediate Adverse Reactions to Gadolinium-Based MR Contrast Media: A Retrospective Analysis on 10,608 Examinations.
abstract: Background and Purpose. Contrast media (CM) for magnetic resonance imaging (MRI) may determine the development of acute adverse reactions. Objective was to retrospectively assess the frequency and severity of adverse reactions associated with gadolinium-based contrast agents (GBCAs) injection in patients who underwent MRI. Material and Methods. At our center 10608 MRI examinations with CM were performed using five different GBCAs: Gd-BOPTA (MultiHance), Gd-DTPA (Magnevist), Gd-EOBDTPA (Primovist), Gd-DOTA (Dotarem), and Gd-BTDO3A (Gadovist). Results. 32 acute adverse reactions occurred, accounting for 0.3% of all administration. Twelve reactions were associated with Gd-DOTA injection (0.11%), 9 with Gd-BOPTA injection (0.08%), 6 with Gd-BTDO3A (0.056%), 3 with Gd-EOB-DTPA (0.028%), and 2 with Gd-DTPA (0.018%). Twenty-four reactions (75.0%) were mild, four (12.5%) moderate, and four (12.5%) severe. The most severe reactions were seen associated with use of Gd-BOPTA, with 3 severe reactions in 32 total reactions. Conclusion. Acute adverse reactions are generally rare with the overall adverse reaction rate of 0.3%. The most common adverse reactions were not severe, consisting in skin rash and hives.
authors.affiliation: Department of Diagnostic Imaging, Radiant and Metabolic Therapy, Istituto Nazionale Tumori "Fondazione G. Pascale" IRCCS, 80131 Naples, Italy.
authors.forename: Vincenza
authors.identifier: 0000-0002-6601-3221
authors.initials: V
authors.lastname: Granata
authors.affiliation: Department of Anesthesia, Endoscopy and Cardiology, Istituto Nazionale Tumori "Fondazione G. Pascale" IRCCS, 80131 Naples, Italy.
authors.forename: Marco
authors.identifier: 0000-0002-5236-3132
authors.initials: M
authors.lastname: Cascella
authors.affiliation: Department of Diagnostic Imaging, Radiant and Metabolic Therapy, Istituto Nazionale Tumori "Fondazione G. Pascale" IRCCS, 80131 Naples, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Fusco
authors.affiliation: Department of Diagnostic Imaging, Radiant and Metabolic Therapy, Istituto Nazionale Tumori "Fondazione G. Pascale" IRCCS, 80131 Naples, Italy.
authors.forename: Nicoletta
authors.initials: N
authors.lastname: dell'Aprovitola
authors.affiliation: Department of Diagnostic Imaging, Radiant and Metabolic Therapy, Istituto Nazionale Tumori "Fondazione G. Pascale" IRCCS, 80131 Naples, Italy.
authors.forename: Orlando
authors.initials: O
authors.lastname: Catalano
authors.affiliation: Department of Diagnostic Imaging, Radiant and Metabolic Therapy, Istituto Nazionale Tumori "Fondazione G. Pascale" IRCCS, 80131 Naples, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Filice
authors.affiliation: UOC Anestesia e Terapia Intensiva, Presidio Ospedaliero "Pineta Grande" Castel Volturno, 81100 Caserta, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Schiavone
authors.affiliation: Department of Hepatobiliary Surgical Oncology, Istituto Nazionale Tumori "Fondazione G. Pascale" IRCCS, 80131 Naples, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Izzo
authors.affiliation: Department of Anesthesia, Endoscopy and Cardiology, Istituto Nazionale Tumori "Fondazione G. Pascale" IRCCS, 80131 Naples, Italy.
authors.forename: Arturo
authors.initials: A
authors.lastname: Cuomo
authors.affiliation: Department of Diagnostic Imaging, Radiant and Metabolic Therapy, Istituto Nazionale Tumori "Fondazione G. Pascale" IRCCS, 80131 Naples, Italy.
authors.forename: Antonella
authors.identifier: 0000-0002-6074-7670
authors.initials: A
authors.lastname: Petrillo
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D003287:Contrast Media / Q000009:adverse effects; D003875:Drug Eruptions / Q000175:diagnosis / Q000453:epidemiology*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005682:Gadolinium / Q000009:adverse effects*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008279:Magnetic Resonance Imaging / Q000009:adverse effects / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology; D015995:Prevalence; D012120:Respiration Disorders / Q000175:diagnosis / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D003287:Contrast Media; D005682:Gadolinium