title: Hepatic Resection After Prehepatectomy Chemotherapy for Metastatic Colorectal Cancer: A Propensity-Matched Analysis.
abstract: Liver metastases from colorectal cancer (CRC) are best managed using multiple modalities, but the role of chemotherapy prior to resection of marginally resectable liver metastases remains unsettled.
  
  
  
  Consecutive patients treated for marginally resectable CRC liver metastases were matched using a propensity-score analysis based on the probability of a patient having up-front surgery or prehepatectomy chemotherapy followed by surgery.
  
  
  
  The study group consisted of 70 propensity-matched patients undergoing up-front surgery or prehepatectomy chemotherapy followed by surgery. Groups were similar in terms of baseline characteristics. Median estimated blood loss (605 ml vs. 957 ml, p=0.006), number of patients requiring transfusion (5 vs. 14, p=0.016) and median postoperative hospital stay (13 vs. 17 days, p=0.005) were significantly less in the prehepatectomy chemotherapy group.
  
  
  
  Hepatic resection after prehepatectomy chemotherapy for patients with marginally resectable CRC liver metastases can lead to favorable short-term outcomes.
authors.affiliation: Department of Surgery, Teikyo University Chiba Medical Center, Chiba, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kawaguchi
authors.affiliation: Department of Surgery, Teikyo University Chiba Medical Center, Chiba, Japan.
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Hiroshima
authors.affiliation: Department of Surgery, Teikyo University Chiba Medical Center, Chiba, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Matsuo
authors.affiliation: Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors.forename: Itaru
authors.initials: I
authors.lastname: Endo
authors.affiliation: Department of Surgery, Teikyo University Chiba Medical Center, Chiba, Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Koda
authors.affiliation: Department of Surgery, Teikyo University Chiba Medical Center, Chiba, Japan U17-92TS@med.teikyo-u.ac.jp.
authors.forename: Kuniya
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D000328:Adult; D000368:Aged; D017024:Chemotherapy, Adjuvant; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008099:Liver / Q000473:pathology / Q000601:surgery*; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D057216:Propensity Score
keywords: Metastatic colorectal cancer; prehepatectomy chemotherapy