title: Epigenetic regulation of peroxiredoxins: Implications in the pathogenesis of cancer.
abstract: Peroxiredoxin I to VI (PRX I-VI), a family of highly conserved antioxidants, has been implicated in numerous diseases. There have been reports that PRXs are expressed aberrantly in a variety of tumors, implying that they could play an important role in carcinogenesis. Epigenetic mechanisms such as DNA methylation, histone modifications, and microRNAs have been reported to modulate expression of PRXs. In addition, the use of epigenetic regulators, such as histone deacetylases, has been demonstrated to restore PRX to normal levels, indicating that the reversible nature of epigenetics can be exploited for future treatments.
authors.affiliation: Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117594, Singapore.
authors.forename: Suet-Hui
authors.initials: SH
authors.lastname: Ow
authors.affiliation: Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117594, Singapore.
authors.forename: Pei-Jou
authors.initials: PJ
authors.lastname: Chua
authors.affiliation: Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117594, Singapore.
authors.forename: Boon-Huat
authors.initials: BH
authors.lastname: Bay
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D063646:Carcinogenesis / Q000473:pathology; D019175:DNA Methylation / Q000235:genetics; D044127:Epigenesis, Genetic / Q000235:genetics*; D042421:Histone Code / Q000502:physiology; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology*; D018384:Oxidative Stress / Q000502:physiology; D054464:Peroxiredoxins / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D035683:MicroRNAs; D006861:Hydrogen Peroxide; D054464:Peroxiredoxins
keywords: Peroxiredoxin; epigenetic regulation; microRNA