title: Multiobjective guided priors improve the accuracy of near-infrared spectral tomography for breast imaging.
abstract: An image reconstruction regularization approach for magnetic resonance imaging-guided near-infrared spectral tomography has been developed to improve quantification of total hemoglobin (HbT) and water. By combining prior information from dynamic contrast enhanced (DCE) and diffusion weighted (DW) MR images, the absolute bias errors of HbT and water in the tumor were reduced by 22% and 18%, 21% and 6%, and 10% and 11%, compared to that in the no-prior, DCE- or DW-guided reconstructed images in three-dimensional simulations, respectively. In addition, the apparent contrast values of HbT and water were increased in patient image reconstruction from 1.4 and 1.4 (DCE) or 1.8 and 1.4 (DW) to 4.6 and 1.6.
authors.affiliation: Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, United StatesbBeijing University of Technology, College of Electronics Information and Control Engineering, Beijing 100124, China.
authors.forename: Jinchao
authors.initials: J
authors.lastname: Feng
authors.affiliation: Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, United States.
authors.forename: Shudong
authors.initials: S
authors.lastname: Jiang
authors.affiliation: Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, United StatescXijing Hospital, Department of Radiology, Xi'an 710032, China.
authors.forename: Junqing
authors.initials: J
authors.lastname: Xu
authors.affiliation: Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, United States.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, United States.
authors.forename: Brian W
authors.initials: BW
authors.lastname: Pogue
authors.affiliation: Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, United States.
authors.forename: Keith D
authors.initials: KD
authors.lastname: Paulsen