title: Non-professional marathon running: RAGE axis and ST2 family changes in relation to open-window effect, inflammation and renal function.
abstract: Conflicting data exist on the relevance of marathon (M) and half marathon (HM) running for health. The number of non-professional athletes finishing M and HM events is steadily growing. In order to investigate molecular changes occurring in amateur athletes, we enrolled 70 non-professional runners finishing a single M (34) or HM (36) event at baseline, the finish line and during recovery, and 30 controls. The measurement of the Receptor for Advanced Glycation Endproducts, Interleukin 1 receptor antagonist, ST2 and cytokeratin 18 was combined with molecules measured during clinical routine. Results were analyzed in the light of blood cell analysis, lactate measurements, correction for changes in plasma volume and body composition assessments. There were intrinsic differences in body mass index, abdominal body fat percentage and training time between M and HM runners. C-reactive protein changes in M and HM runners. While soluble RAGE, AGEs and ST2 increased immediately after the race in HM runners, HMGB1 increased in HM and M after the race and declined to baseline after a recovery period. We give insights into the regulation of various molecules involved in physical stress reactions and their possible implications for the cardiovascular system or renal function.
authors.affiliation: Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University Vienna, Austria.|Department of Obstetrics and Gynaecology, Division of Gynaecology and Gynecological Oncology, Medical University Vienna, Austria.
authors.forename: Christine
authors.initials: C
authors.lastname: Bekos
authors.affiliation: Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University Vienna, Austria.
authors.forename: Matthias
authors.initials: M
authors.lastname: Zimmermann
authors.affiliation: Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University Vienna, Austria.
authors.forename: Lukas
authors.initials: L
authors.lastname: Unger
authors.affiliation: Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University Vienna, Austria.
authors.forename: Stefan
authors.initials: S
authors.lastname: Janik
authors.affiliation: Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University Vienna, Austria.
authors.forename: Philipp
authors.initials: P
authors.lastname: Hacker
authors.affiliation: Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University Vienna, Austria.
authors.forename: Andreas
authors.initials: A
authors.lastname: Mitterbauer
authors.affiliation: Sportordination, Alserstraße 27/1/6, Vienna, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Koller
authors.affiliation: Sportordination, Alserstraße 27/1/6, Vienna, Austria.
authors.forename: Robert
authors.initials: R
authors.lastname: Fritz
authors.affiliation: Sportordination, Alserstraße 27/1/6, Vienna, Austria.
authors.forename: Christian
authors.initials: C
authors.lastname: Gäbler
authors.affiliation: Austrian Red Cross, Nottendorfer Gasse 21, 1030 Wien, Austria.
authors.forename: Mario
authors.initials: M
authors.lastname: Kessler
authors.affiliation: Department of Surgery, Division of Plastic and Reconstructive Surgery, Medical University Vienna, Austria.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Nickl
authors.affiliation: Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University Vienna, Austria.
authors.forename: Jessica
authors.initials: J
authors.lastname: Didcock
authors.affiliation: Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University Vienna, Austria.
authors.forename: Patrick
authors.initials: P
authors.lastname: Altmann
authors.affiliation: Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University Vienna, Austria.|Department of Trauma Surgery, Medical University Vienna, Austria.
authors.forename: Thomas
authors.initials: T
authors.lastname: Haider
authors.affiliation: Department of Anesthesia, Critical Care and Pain Medicine, Medical University Vienna, Austria.
authors.forename: Georg
authors.initials: G
authors.lastname: Roth
authors.affiliation: Department of Surgery, Division of Thoracic Surgery, Medical University Vienna, Austria.
authors.forename: Walter
authors.initials: W
authors.lastname: Klepetko
authors.affiliation: Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University Vienna, Austria.|Department of Surgery, Division of Thoracic Surgery, Medical University Vienna, Austria.
authors.forename: Hendrik Jan
authors.initials: HJ
authors.lastname: Ankersmit
authors.affiliation: Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University Vienna, Austria.|Department of Surgery, Division of Thoracic Surgery, Medical University Vienna, Austria.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Moser