title: Rates of Positive Findings on Positron Emission Tomography and Bone Marrow Biopsy in Patients With Ocular Adnexal Lymphoma.
abstract: OBJECTIVE
  The aim of this study was to determine rates of positive findings on positron emission tomography (PET) and bone marrow biopsy performed during staging workup for ocular adnexal lymphoma (OAL).
  
  
  METHODS
  A retrospective review of OAL patients was conducted. Demographics, primary versus secondary OAL, histologic subtype, and findings on PET and bone marrow biopsy performed as part of the initial staging workup for OAL were recorded.
  
  
  RESULTS
  The study included 119 patients with OAL. There were 85 primary and 34 secondary OALs. The main histologic subtypes of lymphoma were mucosa-associated lymphoid tissue (n = 61), follicular (n = 26), diffuse large B-cell (n = 17), and mantle cell (n = 10). Positive PET findings were seen in 42 of 68 patients (62%) with primary OAL and 19 of 24 (79%) with secondary OAL. Positive PET findings were seen in 24 of 47 patients (51%) with mucosa-associated lymphoid tissue, 13 of 17 (76%) with follicular, 14 of 15 (93%) with diffuse large B-cell, and 9 of 10 (90%) with mantle cell lymphoma. Positive findings on bone marrow biopsy were seen in 7 of 59 patients (12%) with mucosa-associated lymphoid tissue, 4 of 23 (17%) with follicular, 1 of 17 (6%) with diffuse large B-cell, and 2 of 9 (22%) with mantle cell lymphoma.
  
  
  CONCLUSIONS
  Our findings suggest that a significant proportion of patients with primary and secondary OAL have positive findings on PET and bone marrow biopsy at initial diagnosis, suggesting a reasonable yield for these tests as part of the initial staging workup in patients with a new diagnosis of OAL.
authors.affiliation: *Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery, †Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, ‡Department of Ophthalmology and Visual Sciences, The University of Texas Medical Branch, Galveston, Texas, U.S.A.; §Narayana Nethralaya, Narayana Health City, Bangalore, India; ‖Department of Lymphoma and Myeloma, ¶Department of Radiation Oncology, and #Department of Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, U.S.A.
authors.forename: Bradley A
authors.initials: BA
authors.lastname: Thuro
authors.forename: Jing
authors.initials: J
authors.lastname: Ning
authors.forename: S Andrew
authors.initials: SA
authors.lastname: Peng
authors.forename: Stanley T
authors.initials: ST
authors.lastname: Pace
authors.forename: Gagan
authors.initials: G
authors.lastname: Dudeja
authors.forename: Omar
authors.initials: O
authors.lastname: Ozgur
authors.forename: Franceso
authors.initials: F
authors.lastname: Turturro
authors.forename: Felipe
authors.initials: F
authors.lastname: Samaniego
authors.forename: Fredrick B
authors.initials: FB
authors.lastname: Hagemeister
authors.forename: Luis E
authors.initials: LE
authors.lastname: Fayad
authors.forename: Nathan H
authors.initials: NH
authors.lastname: Fowler
authors.forename: Chelsea C
authors.initials: CC
authors.lastname: Pinnix
authors.forename: J Matthew
authors.initials: JM
authors.lastname: Debnam
authors.forename: Bita
authors.initials: B
authors.lastname: Esmaeli
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology*; D003230:Conjunctival Neoplasms / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods*; D009918:Orbital Neoplasms / Q000175:diagnosis*; D049268:Positron-Emission Tomography / Q000379:methods*; D012189:Retrospective Studies; D055815:Young Adult