title: Terbium-doped manganese carbonate nanoparticles with intrinsic photoluminescence and magnetic resonance imaging capacity.
abstract: Herein, we present the first example of manganese carbonate (MnCO3) nanoparticles (NPs) featuring intrinsic photoluminescence (PL) and magnetic resonance (MR) imaging capacity by Terbium (Tb) doping. The Tb-doped MnCO3NPs were prepared by one-step thermal decomposition of Mn-oleate precursor in the presence of Tb-oleate. The oleate capped Tb-doped MnCO3NPs are in rhombohedral shape with an average size of about 13nm. When endowed with high water-dispersible via replacing oleate with carboxylic silane, the Tb-doped MnCO3NPs exhibit distinct intrinsic PL originated from the doped Tb3+ions. Meanwhile, the MR imaging capacity of Tb-doped MnCO3NPs is well retained, as demonstrated by a high r1relaxivity of 4.0428mM-1s-1and a significant MR contrast enhancement effect towards tiny brain glioma in mice.
authors.affiliation: School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, PR China.
authors.forename: Kang
authors.initials: K
authors.lastname: Liu
authors.affiliation: School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Shi
authors.affiliation: Department of Neurosurgery, Beijing Sanbo Brain Hospital, Capital Medical University, Beijing 100093, PR China.
authors.forename: Tingjian
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Beijing Sanbo Brain Hospital, Capital Medical University, Beijing 100093, PR China.
authors.forename: Penghui
authors.initials: P
authors.lastname: Ai
authors.affiliation: School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, PR China. Electronic address: weigu@ccmu.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Gu
authors.affiliation: School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, PR China. Electronic address: lingye@ccmu.edu.cn.
authors.forename: Ling
authors.initials: L
authors.lastname: Ye
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000648:ultrastructure; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000648:ultrastructure; D002254:Carbonates / Q000737:chemistry*; D003287:Contrast Media / Q000737:chemistry / Q000493:pharmacokinetics; D005910:Glioma / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000648:ultrastructure; D049449:Luminescence; D008163:Luminescent Measurements; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008345:Manganese / Q000737:chemistry*; D051379:Mice; D008813:Mice, Inbred ICR; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D019301:Oleic Acid / Q000737:chemistry; D010316:Particle Size; D012821:Silanes / Q000737:chemistry; D013725:Terbium / Q000737:chemistry*
chemical_list: D002254:Carbonates; D003287:Contrast Media; D012821:Silanes; D013725:Terbium; D019301:Oleic Acid; D008345:Manganese; C045327:manganese carbonate
keywords: Brain glioma; Magnetic resonance (MR) imaging; Manganese carbonate (MnCO(3)) nanoparticles; Photoluminescence (PL); Terbium (Tb) doping