title: Structure, anti-Phytophthora and anti-tumor activities of a nortriterpenoid from the rhizome of Phlomis purpurea (Lamiaceae).
abstract: To investigate bioactive compounds potentially involved in the biotic interactions exhibited by Phlomis purpurea (Lamiaceae) in rhizospheres infested with Phytophthora cinnamomi, the plant rhizome was chemically analysed. The nortriterpenoid (17S)-2α,3α,11α,23,24-pentahydroxy-19(18 → 17)-abeo-28-norolean-12-en-18-one, was isolated and its structure was elucidated by comprehensive spectroscopic analysis, chiefly using 2D NMR experiments, and X-ray analysis. It was shown to be exuded by roots and to exhibit anti-Phytophthora and antitumor activities.
authors.affiliation: Chemistry Research Centre of Algarve (CIQA), Faculdade de Ciências e Tecnologia, Universidade do Algarve, Campus de Gambelas, 8005-139, Faro, Portugal.
authors.forename: Maria C
authors.initials: MC
authors.lastname: Mateus
authors.affiliation: Faculdade de Ciências e Tecnologia, Universidade do Algarve, Campus de Gambelas, 8005-139, Faro, Portugal.
authors.forename: Dina
authors.initials: D
authors.lastname: Neves
authors.affiliation: Unidade de Difraccion de RaiosX, RIAIDT, Edificio CACTUS, Campus Sur, 15782, Santiago de Compostela, A Coruña, Spain.
authors.forename: Bruno
authors.initials: B
authors.lastname: Dacunha
authors.affiliation: Functional Genomics Center, UZH / ETHZ, Winterthurerstr. 190, CH-8057, Zürich, Switzerland.
authors.forename: Endre
authors.initials: E
authors.lastname: Laczko
authors.affiliation: Faculdade de Ciências e Tecnologia, Universidade do Algarve, Campus de Gambelas, 8005-139, Faro, Portugal.
authors.forename: Cristiana
authors.initials: C
authors.lastname: Maia
authors.affiliation: Faculdade de Ciências e Tecnologia, Universidade do Algarve, Campus de Gambelas, 8005-139, Faro, Portugal.
authors.forename: Rúben
authors.initials: R
authors.lastname: Teixeira
authors.affiliation: Centre for Mediterranean Bioresourses and Food, FCT, Universidade do Algarve, Campus de Gambelas, 8005-139, Faro, Portugal. Electronic address: acravad@ualg.pt.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Cravador
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D031345:Phlomis / Q000737:chemistry*; D010838:Phytophthora / Q000187:drug effects*; D018517:Plant Roots / Q000737:chemistry; D011174:Portugal; D027343:Rhizome / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D014315:Triterpenes
keywords: Anti-Phytophthora; Bioassays; Chemical structure; Cytotoxic activity; Exudate; Lamiaceae; Phlomis purpurea; Triterpene