title: Correlation of 3D Arterial Spin Labeling and Multi-Parametric Dynamic Susceptibility Contrast Perfusion MRI in Brain Tumors.
abstract: OBJECTIVE
  Arterial spin labeling (ASL) is an alternative method to Dynamic susceptibility contrast (DSC) perfusion MRI for brain tumors. However, ASL cerebral blood flow (CBF) can be easily affected by transit time. DSC MRI derived time to maximum of the residue function (Tmax) is possible to assess the transit time on ASL.
  
  
  METHODS
  Thirty patients with brain tumors were studied using ASL and DSC MRI. The relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), Tmax, and mean transit time (MTT) were obtained from DSC MRI. The ratios of the parameters were analyzed.
  
  
  RESULTS
  ASL CBF ratio correlated with the DSC rCBF ratio (r=0.78, p<0.001) and rCBV ratio (r=0.74, p<0.001). There was a moderate correlation between ASL CBF ratio and Tmax ratio (r=-0.43, p<0.05) in brain tumors.
  
  
  CONCLUSIONS
  ASL CBF strongly correlated with DSC rCBF and rCBV. In addition, a negative correlation was found between ASL CBF and Tmax in brain tumors, indicating that these parameters would be affected by transit time. This may explain why ASL CBF is different from DSC rCBF and rCBV. The decreased DSC Tmax value may suggest high vascularity in a tumor. J. Med. Invest. 63: 175-181, August, 2016.
authors.affiliation: Department of Radiology and Radiation Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School.
authors.forename: Delgerdalai
authors.initials: D
authors.lastname: Khashbat Md
authors.forename: Takashi
authors.initials: T
authors.lastname: Abe Md
authors.forename: Mungunbagana
authors.initials: M
authors.lastname: Ganbold Md
authors.forename: Seiji
authors.initials: S
authors.lastname: Iwamoto Md
authors.forename: Naoto
authors.initials: N
authors.lastname: Uyama Md
authors.forename: Saho
authors.initials: S
authors.lastname: Irahara Md
authors.forename: Youichi
authors.initials: Y
authors.lastname: Otomi Md PhD
authors.forename: Masafumi
authors.initials: M
authors.lastname: Harada Md PhD
authors.forename: Teruyoshi
authors.initials: T
authors.lastname: Kageji Md PhD
authors.forename: Shinji
authors.initials: S
authors.lastname: Nagahiro Md PhD
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation; D003287:Contrast Media; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D055420:Perfusion Imaging / Q000379:methods*; D013113:Spin Labels
chemical_list: D003287:Contrast Media; D013113:Spin Labels