title: Antiviral therapeutics for the treatment of Ebola virus infection.
abstract: There have been significant developments in Ebola virus therapeutics. While the efficacy of several products was evaluated in the recent West Africa outbreak, a licensed treatment for EBOV disease remains elusive. Factors that negatively impacted the execution of clinical trials included an overall lack of world readiness to conduct clinical trials in an outbreak setting, ethical concerns limiting implementation of the randomized controlled trials in an outbreak setting, and a decline in case numbers by the time resources were mobilized to conduct clinical trials. We summarize relevant therapeutics that underwent clinical trials during the West Africa outbreak and highlight promising candidates under advanced development.
authors.affiliation: Division of Medicine, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Frederick, MD 21702, USA. Electronic address: anthony.p.cardile.mil@mail.mil.
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Cardile
authors.affiliation: Division of Medicine, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Frederick, MD 21702, USA.
authors.forename: Lydia G
authors.initials: LG
authors.lastname: Downey
authors.affiliation: Division of Medicine, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Frederick, MD 21702, USA.
authors.forename: Perry D
authors.initials: PD
authors.lastname: Wiseman
authors.affiliation: Translational Medicine Division, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Frederick, MD 21702, USA.
authors.forename: Travis K
authors.initials: TK
authors.lastname: Warren
authors.affiliation: US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Frederick, MD 21702, USA.
authors.forename: Sina
authors.initials: S
authors.lastname: Bavari
mesh_terms: D000354:Africa, Western / Q000453:epidemiology; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D004196:Disease Outbreaks; D015195:Drug Design; D029043:Ebolavirus / Q000187:drug effects*; D019142:Hemorrhagic Fever, Ebola / Q000188:drug therapy* / Q000453:epidemiology / Q000821:virology; D006801:Humans; D016032:Randomized Controlled Trials as Topic / Q000941:ethics / Q000379:methods
chemical_list: D000998:Antiviral Agents