title: The prediction roles of asymmetric dimethyl-arginine, adiponectin and apelin for macroangiopathy in patients with impaired glucose regulation.
abstract: OBJECTIVE
  To investigate the effects of asymmetric dimethyl-arginine (ADMA), adiponectin (APN) and apelin in predicting macroangiopathy in impaired glucose regulation (IGR) patients.
  
  
  METHODS
  A total of 210 patients undergoing oral glucose tolerance test were included in this study. They were classified to normal glucose tolerance (NGT, n=42), impaired fasting glucose (IFG, n=36), impaired glucose tolerance (IGT, n=92, including 44 IGT1 and 48 IGT2 patients) and IFG+IGT (n=40) groups. APN, apelin and ADMA levels, blood pressure, blood lipid, insulin, body mass index (BMI), and homeostasis model assessment of insulin resistance (HOMA-IR) were detected. The severity and extent of coronary atherosclerosis were determined by the Gensini score.
  
  
  RESULTS
  The prevalence of coronary heart disease and Gensini scores in IGT and IFG+IGT groups were similar but both were higher than NGT and IFG groups (all P<0.05). Lower APN, higher ADMA and apelin levels were witnessed in IGT and IGT+IFG groups compared with NGT and IFG groups (all P<0.05). IGT2 group had higher 2-h PG and apelin levels and Gensini scores but lower APN levels than IGT1 group (all P<0.05). Gensini score was positively correlated with apelin (r=0.669) and ADMA (r=0.764), but were negatively correlated with APN (r=-0.555, all P<0.001). ADMA and APN were the independent factors affecting Gensini score.
  
  
  CONCLUSIONS
  ADMA and APN levels could be predictive factors for macroangiopathy in IGR patients, especially in IGT cases.
authors.affiliation: Endocrinology Department, Changhai Hospital, Second Military Medical University, Changhai Road No. 174, 200433 Shanghai, PR China; Endocrinology Department, Shanghai Tongren hospital Affiliated to Shanghai Jiaotong University School of Medicine, 200336 Shanghai, PR China.
authors.forename: Shan
authors.initials: S
authors.lastname: Huang
authors.affiliation: Endocrinology Department, Changhai Hospital, Second Military Medical University, Changhai Road No. 174, 200433 Shanghai, PR China. Electronic address: dajinzou_zd@163.com.
authors.forename: Dajin
authors.initials: D
authors.lastname: Zou
authors.affiliation: Endocrinology Department, Shanghai Tongren hospital Affiliated to Shanghai Jiaotong University School of Medicine, 200336 Shanghai, PR China.
authors.forename: Wenfang
authors.initials: W
authors.lastname: Peng
authors.affiliation: Endocrinology Department, Shanghai Tongren hospital Affiliated to Shanghai Jiaotong University School of Medicine, 200336 Shanghai, PR China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Endocrinology Department, Shanghai Tongren hospital Affiliated to Shanghai Jiaotong University School of Medicine, 200336 Shanghai, PR China.
authors.forename: Kan
authors.initials: K
authors.lastname: Shao
authors.affiliation: Endocrinology Department, Shanghai Tongren hospital Affiliated to Shanghai Jiaotong University School of Medicine, 200336 Shanghai, PR China.
authors.forename: Lili
authors.initials: L
authors.lastname: Xia
authors.affiliation: Endocrinology Department, Shanghai Tongren hospital Affiliated to Shanghai Jiaotong University School of Medicine, 200336 Shanghai, PR China.
authors.forename: Yubin
authors.initials: Y
authors.lastname: Tang
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000073861:Apelin; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D050197:Atherosclerosis / Q000097:blood / Q000150:complications; D001786:Blood Glucose / Q000378:metabolism; D003327:Coronary Disease / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D005260:Female; D018149:Glucose Intolerance / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000097:blood / Q000150:complications / Q000175:diagnosis; D011379:Prognosis
chemical_list: C499918:ADIPOQ protein, human; C115436:APLN protein, human; D052242:Adiponectin; D000073861:Apelin; D001786:Blood Glucose; D036341:Intercellular Signaling Peptides and Proteins; C018524:N,N-dimethylarginine; D001120:Arginine
keywords: Adiponectin; Adiponectine; Apelin; Asymmetric dimethyl-arginine; Diméthyl-arginine asymétrique; Gensini score; Impaired glucose regulation; Troubles de la glycémie