title: Lack of Association Between Subclinical Hypothyroidism and Carotid-Femoral Pulse Wave Velocity in a Cross-Sectional Analysis of the ELSA-Brasil.
abstract: BACKGROUND
  There is little available data on carotid-femoral pulse wave velocity (cf-PWV) in subjects with subclinical hypothyroidism (SCH). We aimed to analyze the association between SCH and cf-PWV using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).
  
  
  METHODS
  We included subjects with normal thyroid function (thyrotropin (TSH): 0.4-4.0 mIU/l, and normal free thyroxine (FT4: 0.8-1.9ng/dl) and SCH (TSH > 4.0 mIU/l and normal FT4) evaluated for cf-PWV in a cross-sectional analysis. We excluded individuals using medications that interfere in thyroid function, antihypertensives, or diuretics, and subjects with chronic kidney disease or previous cardiovascular disease. Generalized linear and logistic regression models evaluated cf-PWV as a dependent variable and SCH as an independent variable, adjusted for cardiovascular risk factors.
  
  
  RESULTS
  Of 8,341 subjects (52.3% women), 7,878 (94.4%) were euthyroid and 463 (5.6%) showed SCH. The median age was 50 years (interquartile range: 44-56). The groups differed by age, sex, body mass index, glomerular filtration rate, and C-reactive protein. SCH was not associated with cf-PWV in the full-adjusted linear model (β = -0.039; P = 0.562) and with cf-PWV >75thpercentile in the full-adjusted logistic model (odds ratio = 0.94; 95% confidence interval = 0.72-1.22).
  
  
  CONCLUSIONS
  In a large sample, SCH was not associated with increased cf-PWV.
authors.affiliation: Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Érique José F
authors.initials: ÉJ
authors.lastname: Peixoto de Miranda
authors.affiliation: Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Márcio Sommer
authors.initials: MS
authors.lastname: Bittencourt
authors.affiliation: Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Alessandra Carvalho
authors.initials: AC
authors.lastname: Goulart
authors.affiliation: Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Itamar Souza
authors.initials: IS
authors.lastname: Santos
authors.affiliation: Departamento de Ciências Fisiológicas, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brazil.
authors.forename: José Geraldo
authors.initials: JG
authors.lastname: Mill
authors.affiliation: Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
authors.forename: Maria Ines
authors.initials: MI
authors.lastname: Schmidt
authors.affiliation: Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Paulo Andrade
authors.initials: PA
authors.lastname: Lotufo
authors.affiliation: Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil; isabensenor@gmail.com.
authors.forename: Isabela J Martins
authors.initials: IJ
authors.lastname: Benseñor
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis
keywords: artery stiffness; blood pressure; cardiovascular risk factors; hypertension; pulse wave velocity; subclinical atherosclerosis; subclinical hypothyroidism; thyroid dysfunction.