title: Paraneoplastic Limbic Encephalitis in a Human Epidermal Growth Factor Receptor-2-positive Gastric Cancer Patient Treated with Trastuzumab-combined Chemotherapy: A Case Report and Literature Review.
abstract: Paraneoplastic neurological syndromes (PNSs) are rare nervous system dysfunctions in cancer patients, which are primarily observed with small-cell lung cancer, gynecological cancer, and thymoma. We herein present an uncommon case of PNS in an anti-Hu antibody-positive patient with human epidermal growth factor receptor (HER)-2-positive gastric cancer (GC), who developed limbic encephalitis and a worsening cognitive function. Trastuzumab-combined chemotherapy was initiated and appeared to be partially effective for controlling the neurological symptoms and tumor volume. Chemotherapy failure eventually led to uncontrollable neurological symptoms. This is the first case demonstrating that trastuzumab-combined chemotherapy may be effective for controlling neurological symptoms of PNS in HER2-positive GC patients.
authors.affiliation: Department of Clinical Oncology, Kyoto University Hospital, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Uneno
authors.forename: Akira
authors.initials: A
authors.lastname: Yokoyama
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Nishikawa
authors.forename: Taro
authors.initials: T
authors.lastname: Funakoshi
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Ozaki
authors.forename: Ikuo
authors.initials: I
authors.lastname: Aoyama
authors.forename: Kiichiro
authors.initials: K
authors.lastname: Baba
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yamaguchi
authors.forename: Shuko
authors.initials: S
authors.lastname: Morita
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Mori
authors.forename: Masashi
authors.initials: M
authors.lastname: Kanai
authors.forename: Hisanori
authors.initials: H
authors.lastname: Kinoshita
authors.forename: Takeshi
authors.initials: T
authors.lastname: Inoue
authors.forename: Nobukatsu
authors.initials: N
authors.lastname: Sawamoto
authors.forename: Riki
authors.initials: R
authors.lastname: Matsumoto
authors.forename: Shigemi
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Manabu
authors.initials: M
authors.lastname: Muto
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D066246:ErbB Receptors; D005260:Female; D006801:Humans; D020363:Limbic Encephalitis / Q000209:etiology*; D008297:Male; D020361:Paraneoplastic Syndromes, Nervous System / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000150:complications*; D000068878:Trastuzumab / Q000627:therapeutic use*
chemical_list: D066246:ErbB Receptors; D000068878:Trastuzumab