title: [Effect of cerebral hemodynamic changes on white matter damage in premature infant with patent ductus arteriosus].
abstract: To investigate the effect of cerebral hemodynamic changes on white matter damage in premature infant with patent ductus arteriosus(PDA).
  
  
  
  A total of 106 premature infants were enrolled in the study, including 35 PDA infants with hemodynamic changes (hsPDA group), 35 PDA infants without hemodynamic changes (non-hsPDA group) and 36 non-PDA infants (control group). Serum level of neuron-specific enolase (NES) was detected and craniocerebral ultrasound examination was performed on d3, d7 and d14 after birth. The correlation between blood flow rate of PDA and gray scale value of lateral ventricle was analyzed.
  
  
  
  Gray scale values of lateral ventricle and serum levels of NES in hsPDA group were higher than those in control group on d3, d7 and d14 (P<0.01), but no significant difference was observed between non-hsPDA group and control group (P>0.05). There was a positive correlation between the blood flow rate of PDA and gray scale value of lateral ventricle (r=0.876, P<0.01) in premature infants.
  
  
  
  Patent ductus arteriosus with hemodynamic changes is closely related to white matter damage in premature infants, and early intervention is necessary.
authors.affiliation: Department of Neonate, BOAI Hospital of Zhongshan Affiliated to Southern Medical University, Zhonshan 528400, China.
authors.forename: L U
authors.initials: LU
authors.lastname: Junxiu
authors.affiliation: Department of Neonate, BOAI Hospital of Zhongshan Affiliated to Southern Medical University, Zhonshan 528400, China. ybyicu@126.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Bingyan
authors.affiliation: Department of Neonate, Zhongshan People's Hospital Affiliated to Sun Yat-sen University, Zhonshan 528403, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Jingguo
authors.affiliation: Department of Neonate, Shenzhen Children's Hospital, Shenzhen 518000, China.
authors.forename: X U
authors.initials: XU
authors.lastname: Huanli
authors.affiliation: Department of Neonate, Zhongshan People's Hospital Affiliated to Sun Yat-sen University, Zhonshan 528403, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Haiyan
mesh_terms: D004374:Ductus Arteriosus, Patent / Q000150:complications*; D006439:Hemodynamics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D014463:Ultrasonography; D066127:White Matter / Q000473:pathology*