title: CXCL4 in undifferentiated connective tissue disease at risk for systemic sclerosis (SSc) (previously referred to as very early SSc).
abstract: The aim of the study was to evaluate CXCL4 levels in undifferentiated connective tissue disease at risk for SSc (UCTD-SSc-risk) and confirm its increase and investigate its prognostic value. Serum CXCL4 levels were measured in 45 patients and 24 controls. CXCL4 was significantly higher in UCTD-SSc-risk patients than in controls. It resulted higher in patients with a shorter disease duration and in those lacking capillaroscopic alterations. We confirm that CXCL4 levels are increased in UCTD-risk-SSc patients. Further studies are needed to investigate the role of CXCL4 assessment in UCTD-risk-SSc.
authors.affiliation: Department of Clinical and Experimental Medicine, Rheumatology Section, Second University of Naples, II Policlinico, Building 3, Via Pansini 5, Naples, Italy. gabriele.valentini@unina2.it.|Division of General and Bariatric Surgery, Second University of Naples, Naples, Italy. gabriele.valentini@unina2.it.|Division of Respiratory Disease, Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, Italy. gabriele.valentini@unina2.it.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Valentini
authors.affiliation: Department of Clinical and Experimental Medicine, Rheumatology Section, Second University of Naples, II Policlinico, Building 3, Via Pansini 5, Naples, Italy.|Division of General and Bariatric Surgery, Second University of Naples, Naples, Italy.|Division of Respiratory Disease, Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Riccardi
authors.affiliation: Department of Clinical and Experimental Medicine, Rheumatology Section, Second University of Naples, II Policlinico, Building 3, Via Pansini 5, Naples, Italy.|Division of General and Bariatric Surgery, Second University of Naples, Naples, Italy.|Division of Respiratory Disease, Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Vettori
authors.affiliation: Department of Clinical and Experimental Medicine, Rheumatology Section, Second University of Naples, II Policlinico, Building 3, Via Pansini 5, Naples, Italy.|Division of General and Bariatric Surgery, Second University of Naples, Naples, Italy.|Division of Respiratory Disease, Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, Italy.
authors.forename: Rosaria
authors.initials: R
authors.lastname: Irace
authors.affiliation: Department of Clinical and Experimental Medicine, Rheumatology Section, Second University of Naples, II Policlinico, Building 3, Via Pansini 5, Naples, Italy.|Division of General and Bariatric Surgery, Second University of Naples, Naples, Italy.|Division of Respiratory Disease, Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Iudici
authors.affiliation: Department of Clinical and Experimental Medicine, Rheumatology Section, Second University of Naples, II Policlinico, Building 3, Via Pansini 5, Naples, Italy.|Division of General and Bariatric Surgery, Second University of Naples, Naples, Italy.|Division of Respiratory Disease, Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Tolone
authors.affiliation: Department of Clinical and Experimental Medicine, Rheumatology Section, Second University of Naples, II Policlinico, Building 3, Via Pansini 5, Naples, Italy.|Division of General and Bariatric Surgery, Second University of Naples, Naples, Italy.|Division of Respiratory Disease, Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, Italy.
authors.forename: Ludovico
authors.initials: L
authors.lastname: Docimo
authors.affiliation: Department of Clinical and Experimental Medicine, Rheumatology Section, Second University of Naples, II Policlinico, Building 3, Via Pansini 5, Naples, Italy.|Division of General and Bariatric Surgery, Second University of Naples, Naples, Italy.|Division of Respiratory Disease, Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, Italy.
authors.forename: Marialuisa
authors.initials: M
authors.lastname: Bocchino
authors.affiliation: Department of Clinical and Experimental Medicine, Rheumatology Section, Second University of Naples, II Policlinico, Building 3, Via Pansini 5, Naples, Italy.|Division of General and Bariatric Surgery, Second University of Naples, Naples, Italy.|Division of Respiratory Disease, Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sanduzzi
authors.affiliation: Department of Clinical and Experimental Medicine, Rheumatology Section, Second University of Naples, II Policlinico, Building 3, Via Pansini 5, Naples, Italy.|Division of General and Bariatric Surgery, Second University of Naples, Naples, Italy.|Division of Respiratory Disease, Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Cozzolino
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010978:Platelet Factor 4 / Q000097:blood*; D011379:Prognosis; D012595:Scleroderma, Systemic / Q000175:diagnosis* / Q000473:pathology*; D000074079:Undifferentiated Connective Tissue Diseases / Q000150:complications* / Q000175:diagnosis / Q000473:pathology*
chemical_list: D010978:Platelet Factor 4
keywords: Systemic sclerosis; Undifferentiated connective tissue disease