title: Treadmill running exercise prevents senile osteoporosis and upregulates the Wnt signaling pathway in SAMP6 mice.
abstract: This study examined the effects of different exercise intensities and durations on bone mineral density (BMD) and bone strength in senescence-accelerated mouse prone 6 (SAMP6) and determined the involvement of the Wnt signaling pathway in exercise-induced osteogenesis. Three-month-old male SAMP6 mice were randomly assigned to different speeds of treadmill running exercise representing low, medium and high intensity, with the duration of five and nine weeks, respectively. We showed that medium-intensity exercise had positive effects on skeletal health, including BMD and bone strength, and the efficacy was higher than that of low-intensity exercise. Interestingly, high-intensity exercise can maintain or even increase bone strength, despite its negative effects on bone mass. Nine weeks of exercise was superior to 5 weeks of exercise, particularly for low-intensity exercise. Furthermore, these effects of exercise-induced osteogenesis are accompanied by activation of the Wnt signaling pathway. Taken together, these results suggest that the positive effects of exercise on osteoporosis prevention are intensity and duration-dependent, and may involve the regulation of Wnt signaling pathways.
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai, P. R. China.|School of Sports Science, Wenzhou Medical University, Wenzhou, P. R. China.|School of Pathology and Laboratory Medicine, The University of Western Australia, Western Australia, Australia.
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai, P. R. China.
authors.forename: Lihui
authors.initials: L
authors.lastname: Li
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai, P. R. China.
authors.forename: Jianmin
authors.initials: J
authors.lastname: Guo
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai, P. R. China.
authors.forename: Lingli
authors.initials: L
authors.lastname: Zhang
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai, P. R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai, P. R. China.
authors.forename: Binglin
authors.initials: B
authors.lastname: Chen
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai, P. R. China.
authors.forename: Zhongguang
authors.initials: Z
authors.lastname: Sun
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai, P. R. China.|School of Pathology and Laboratory Medicine, The University of Western Australia, Western Australia, Australia.
authors.forename: Jiake
authors.initials: J
authors.lastname: Xu
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai, P. R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zou
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001696:Biomechanical Phenomena; D015519:Bone Density; D001842:Bone and Bones / Q000473:pathology / Q000502:physiology; D004195:Disease Models, Animal; D060492:Low Density Lipoprotein Receptor-Related Protein-5 / Q000235:genetics; D008297:Male; D051379:Mice; D010024:Osteoporosis / Q000517:prevention & control*; D012420:Running; D015854:Up-Regulation; D060449:Wnt Signaling Pathway / Q000502:physiology*; D051176:beta Catenin / Q000235:genetics
chemical_list: C495267:CTNNB1 protein, mouse; D060492:Low Density Lipoprotein Receptor-Related Protein-5; C555483:Lrp5 protein, mouse; D051176:beta Catenin; D000469:Alkaline Phosphatase
keywords: Gerotarget; SAMP6; Wnt signaling pathway; exercise; osteoporosis; senile