title: Cellular senescence in aging and osteoarthritis.
abstract: - It is well accepted that age is an important contributing factor to poor cartilage repair following injury, and to the development of osteoarthritis. Cellular senescence, the loss of the ability of cells to divide, has been noted as the major factor contributing to age-related changes in cartilage homeostasis, function, and response to injury. The underlying mechanisms of cellular senescence, while not fully understood, have been associated with telomere erosion, DNA damage, oxidative stress, and inflammation. In this review, we discuss the causes and consequences of cellular senescence, and the associated biological challenges in cartilage repair. In addition, we present novel strategies for modulation of cellular senescence that may help to improve cartilage regeneration in an aging population.
authors.affiliation: a Faculty of Dentistry , National University of Singapore.|b Tissue Engineering Program , Life Sciences Institute, National University of Singapore , Singapore.
authors.forename: Wei Seong
authors.initials: WS
authors.lastname: Toh
authors.affiliation: c Cartilage Research Unit, University of Gothenburg , Gothenburg.|d Department of Orthopaedics , Kungsbacka Hospital , Kungsbacka , Sweden.
authors.forename: Mats
authors.initials: M
authors.lastname: Brittberg
authors.affiliation: e Indiana University School of Medicine, OrthoIndy Cartilage Restoration Center , Indianapolis , IN , USA.
authors.forename: Jack
authors.initials: J
authors.lastname: Farr
authors.affiliation: f Orthopaedic Research Laboratory , Aarhus University Hospital , Aarhus , Denmark.
authors.forename: Casper Bindzus
authors.initials: CB
authors.lastname: Foldager
authors.affiliation: g Cartilage Repair Center, Brigham and Women's Hospital, Harvard Medical School , Boston , MA , USA.
authors.forename: Andreas H
authors.initials: AH
authors.lastname: Gomoll
authors.affiliation: b Tissue Engineering Program , Life Sciences Institute, National University of Singapore , Singapore.|h Cartilage Repair Program, Therapeutic Tissue Engineering Laboratory, Department of Orthopaedic Surgery , National University Health System, National University of Singapore , Singapore.
authors.forename: James Hoi Po
authors.initials: JH
authors.lastname: Hui
authors.affiliation: i Robert Jones and Agnes Hunt Orthopaedic Hospital , Oswestry , Shropshire.|j Institute for Science andTechnology in Medicine, Keele University , Keele , Staffordshire , UK.
authors.forename: James B
authors.initials: JB
authors.lastname: Richardson
authors.affiliation: i Robert Jones and Agnes Hunt Orthopaedic Hospital , Oswestry , Shropshire.|j Institute for Science andTechnology in Medicine, Keele University , Keele , Staffordshire , UK.
authors.forename: Sally
authors.initials: S
authors.lastname: Roberts
authors.affiliation: k Department of Orthopaedic Surgery , Brigham and Women's Hospital, Harvard Medical School , Boston , MA , USA.|l Tissue Engineering Laboratories , VA Boston Healthcare System , Boston , MA , USA.
authors.forename: Myron
authors.initials: M
authors.lastname: Spector
mesh_terms: D000375:Aging / Q000502:physiology*; D000975:Antioxidants / Q000494:pharmacology; D002358:Cartilage, Articular / Q000473:pathology / Q000502:physiology; D016922:Cellular Senescence / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D006801:Humans; D010003:Osteoarthritis / Q000473:pathology* / Q000503:physiopathology; D018384:Oxidative Stress / Q000502:physiology; D012038:Regeneration / Q000187:drug effects / Q000502:physiology; D059505:Telomere Homeostasis / Q000502:physiology
chemical_list: D000975:Antioxidants