title: Lower cranial polyneuropathy in zoster sine herpete presenting with pain in the ear and throat: a case report.
abstract: A 64-year-old woman developed acute paralysis of glossopharyngeal, vagus, accessory, and hypoglossal nerves on the left side after pain in the head and the left ear and throat. Cerebrospinal fluid examination revealed lymphocytic pleocytosis and elevated protein concentration. Varicella-zoster virus (VZV)-DNA was detected by PCR from cerebrospinal fluid. The diagnosis of lower cranial polyneuropathy due to VZV reactivation was made. After oral administration of an anti-viral agent and steroid, all symptoms and signs dramatically improved. Notably, there was no evidence of cutaneous or mucosal rash during the whole course of the disease. VZV reactivation should be included in the differential diagnosis of acute lower cranial polyneuropathy, especially with pain in the ear and throat, even without cutaneous or mucosal rash.
authors.affiliation: Division of Neurology, Department of Internal Medicine I, Osaka Medical College.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Hosokawa
authors.forename: Hideto
authors.initials: H
authors.lastname: Nakajima
authors.forename: Akihiro
authors.initials: A
authors.lastname: Tsukahara
authors.forename: Kiich
authors.initials: K
authors.lastname: Unoda
authors.forename: Shimon
authors.initials: S
authors.lastname: Ishida
authors.forename: Fumiharu
authors.initials: F
authors.lastname: Kimura
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage / Q000031:analogs & derivatives; D000284:Administration, Oral; D000998:Antiviral Agents / Q000008:administration & dosage; D001623:Betamethasone / Q000008:administration & dosage; D015415:Biomarkers / Q000134:cerebrospinal fluid; D003389:Cranial Nerve Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D004279:DNA, Viral / Q000134:cerebrospinal fluid; D004359:Drug Therapy, Combination; D004423:Ear; D005260:Female; D014645:Herpesvirus 3, Human / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy / Q000209:etiology*; D010614:Pharynx; D016896:Treatment Outcome; D000077483:Valacyclovir; D014633:Valine / Q000008:administration & dosage / Q000031:analogs & derivatives; D031368:Zoster Sine Herpete / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D000998:Antiviral Agents; D015415:Biomarkers; D004279:DNA, Viral; D001623:Betamethasone; D014633:Valine; D000077483:Valacyclovir; D000212:Acyclovir