title: Relationship of Albuminuria and Renal Artery Stent Outcomes: Results From the CORAL Randomized Clinical Trial (Cardiovascular Outcomes With Renal Artery Lesions).
abstract: Randomized clinical trials have not shown an additional clinical benefit of renal artery stent placement over optimal medical therapy alone. However, studies of renal artery stent placement have not examined the relationship of albuminuria and treatment group outcomes. The CORAL study (Cardiovascular Outcomes in Renal Atherosclerotic Lesions) is a prospective clinical trial of 947 participants with atherosclerotic renal artery stenosis randomized to optimal medical therapy with or without renal artery stent which showed no treatment differences (3(5.8% and 35.1% event rate at mean 43-month follow-up). In a post hoc analysis, the study population was stratified by the median baseline urine albumin/creatinine ratio (n=826) and analyzed for the 5-year incidence of the primary end point (myocardial infarction, hospitalization for congestive heart failure, stroke, renal replacement therapy, progressive renal insufficiency, or cardiovascular disease- or kidney disease-related death), for each component of the primary end point, and overall survival. When baseline urine albumin/creatinine ratio was ≤ median (22.5 mg/g, n=413), renal artery stenting was associated with significantly better event-free survival from the primary composite end point (73% versus 59% at 5 years; P=0.02), cardiovascular disease-related death (93% versus 85%; P≤ 0.01), progressive renal insufficiency (91% versus 77%; P=0.03), and overall survival (89% versus 76%; P≤0.01), but not when baseline urine albumin/creatinine ratio was greater than median (n=413). These data suggest that low albuminuria may indicate a potentially large subgroup of those with renal artery stenosis that could experience improved event-free and overall-survival after renal artery stent placement plus optimal medical therapy compared with optimal medical therapy alone. Further research is needed to confirm these preliminary observations.
  
  
  
  URL: https://www.clinicaltrials.gov. Unique identifier: NCT00081731.
authors.affiliation: From the Departments of Diagnostic Imaging (T.P.M.) and Medicine (L.D.D.), Rhode Island Hospital, Providence; Alpert Medical School of Brown University, Providence, RI (T.P.M., L.D.D.); Department of Medicine, University of Toledo, OH (C.J.C.); Departments of Statistics (K.M.P., R.B.D, J.M.M.), Medicine (D.E.C.), and Biostatistics (Q.G.), Harvard Clinical Research Institute, Boston, MA; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.E.C.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Medicine, University of Michigan, Ann Arbor (K.J.); Department of Radiology, University of Virginia, Charlottesville (A.H.M.); Department of Medicine, University of Texas Health Science Center, San Antonio (W.H.); Department of Medicine, Marshall University, Huntington, WV (J.I.S.); Department of Medicine, Providence Health Care and University of Washington School of Medicine, Spokane (K.R.T.); Department of Medicine, St. Luke's Hospital, Kansas City, MO (D.J.C.); Departments of Pathology (M.S.) and Medicine (A.H.), The University of Minnesota Medical School, Minneapolis; Department of Medicine, Wellmont-Holston Valley Medical Center, Kingsport, TN (D.C.M.); Department of Medicine, Asheville Cardiology Associates, NC (W.B.A.); Department of Medicine, Mayo Clinic, Rochester, MN (S.C.T.); Department of Radiology, Lancaster General Hospital, PA (J.B.); and Department of Medicine, Sunnybrook Research Institute (S.T.), Toronto, Ontario, Canada. tmurphy@lifespan.org.
authors.forename: Timothy P
authors.initials: TP
authors.lastname: Murphy
authors.affiliation: From the Departments of Diagnostic Imaging (T.P.M.) and Medicine (L.D.D.), Rhode Island Hospital, Providence; Alpert Medical School of Brown University, Providence, RI (T.P.M., L.D.D.); Department of Medicine, University of Toledo, OH (C.J.C.); Departments of Statistics (K.M.P., R.B.D, J.M.M.), Medicine (D.E.C.), and Biostatistics (Q.G.), Harvard Clinical Research Institute, Boston, MA; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.E.C.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Medicine, University of Michigan, Ann Arbor (K.J.); Department of Radiology, University of Virginia, Charlottesville (A.H.M.); Department of Medicine, University of Texas Health Science Center, San Antonio (W.H.); Department of Medicine, Marshall University, Huntington, WV (J.I.S.); Department of Medicine, Providence Health Care and University of Washington School of Medicine, Spokane (K.R.T.); Department of Medicine, St. Luke's Hospital, Kansas City, MO (D.J.C.); Departments of Pathology (M.S.) and Medicine (A.H.), The University of Minnesota Medical School, Minneapolis; Department of Medicine, Wellmont-Holston Valley Medical Center, Kingsport, TN (D.C.M.); Department of Medicine, Asheville Cardiology Associates, NC (W.B.A.); Department of Medicine, Mayo Clinic, Rochester, MN (S.C.T.); Department of Radiology, Lancaster General Hospital, PA (J.B.); and Department of Medicine, Sunnybrook Research Institute (S.T.), Toronto, Ontario, Canada.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Cooper
authors.affiliation: From the Departments of Diagnostic Imaging (T.P.M.) and Medicine (L.D.D.), Rhode Island Hospital, Providence; Alpert Medical School of Brown University, Providence, RI (T.P.M., L.D.D.); Department of Medicine, University of Toledo, OH (C.J.C.); Departments of Statistics (K.M.P., R.B.D, J.M.M.), Medicine (D.E.C.), and Biostatistics (Q.G.), Harvard Clinical Research Institute, Boston, MA; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.E.C.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Medicine, University of Michigan, Ann Arbor (K.J.); Department of Radiology, University of Virginia, Charlottesville (A.H.M.); Department of Medicine, University of Texas Health Science Center, San Antonio (W.H.); Department of Medicine, Marshall University, Huntington, WV (J.I.S.); Department of Medicine, Providence Health Care and University of Washington School of Medicine, Spokane (K.R.T.); Department of Medicine, St. Luke's Hospital, Kansas City, MO (D.J.C.); Departments of Pathology (M.S.) and Medicine (A.H.), The University of Minnesota Medical School, Minneapolis; Department of Medicine, Wellmont-Holston Valley Medical Center, Kingsport, TN (D.C.M.); Department of Medicine, Asheville Cardiology Associates, NC (W.B.A.); Department of Medicine, Mayo Clinic, Rochester, MN (S.C.T.); Department of Radiology, Lancaster General Hospital, PA (J.B.); and Department of Medicine, Sunnybrook Research Institute (S.T.), Toronto, Ontario, Canada.
authors.forename: Karol M
authors.initials: KM
authors.lastname: Pencina
authors.affiliation: From the Departments of Diagnostic Imaging (T.P.M.) and Medicine (L.D.D.), Rhode Island Hospital, Providence; Alpert Medical School of Brown University, Providence, RI (T.P.M., L.D.D.); Department of Medicine, University of Toledo, OH (C.J.C.); Departments of Statistics (K.M.P., R.B.D, J.M.M.), Medicine (D.E.C.), and Biostatistics (Q.G.), Harvard Clinical Research Institute, Boston, MA; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.E.C.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Medicine, University of Michigan, Ann Arbor (K.J.); Department of Radiology, University of Virginia, Charlottesville (A.H.M.); Department of Medicine, University of Texas Health Science Center, San Antonio (W.H.); Department of Medicine, Marshall University, Huntington, WV (J.I.S.); Department of Medicine, Providence Health Care and University of Washington School of Medicine, Spokane (K.R.T.); Department of Medicine, St. Luke's Hospital, Kansas City, MO (D.J.C.); Departments of Pathology (M.S.) and Medicine (A.H.), The University of Minnesota Medical School, Minneapolis; Department of Medicine, Wellmont-Holston Valley Medical Center, Kingsport, TN (D.C.M.); Department of Medicine, Asheville Cardiology Associates, NC (W.B.A.); Department of Medicine, Mayo Clinic, Rochester, MN (S.C.T.); Department of Radiology, Lancaster General Hospital, PA (J.B.); and Department of Medicine, Sunnybrook Research Institute (S.T.), Toronto, Ontario, Canada.
authors.forename: Ralph
authors.initials: R
authors.lastname: D'Agostino
authors.affiliation: From the Departments of Diagnostic Imaging (T.P.M.) and Medicine (L.D.D.), Rhode Island Hospital, Providence; Alpert Medical School of Brown University, Providence, RI (T.P.M., L.D.D.); Department of Medicine, University of Toledo, OH (C.J.C.); Departments of Statistics (K.M.P., R.B.D, J.M.M.), Medicine (D.E.C.), and Biostatistics (Q.G.), Harvard Clinical Research Institute, Boston, MA; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.E.C.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Medicine, University of Michigan, Ann Arbor (K.J.); Department of Radiology, University of Virginia, Charlottesville (A.H.M.); Department of Medicine, University of Texas Health Science Center, San Antonio (W.H.); Department of Medicine, Marshall University, Huntington, WV (J.I.S.); Department of Medicine, Providence Health Care and University of Washington School of Medicine, Spokane (K.R.T.); Department of Medicine, St. Luke's Hospital, Kansas City, MO (D.J.C.); Departments of Pathology (M.S.) and Medicine (A.H.), The University of Minnesota Medical School, Minneapolis; Department of Medicine, Wellmont-Holston Valley Medical Center, Kingsport, TN (D.C.M.); Department of Medicine, Asheville Cardiology Associates, NC (W.B.A.); Department of Medicine, Mayo Clinic, Rochester, MN (S.C.T.); Department of Radiology, Lancaster General Hospital, PA (J.B.); and Department of Medicine, Sunnybrook Research Institute (S.T.), Toronto, Ontario, Canada.
authors.forename: Joseph
authors.initials: J
authors.lastname: Massaro
authors.affiliation: From the Departments of Diagnostic Imaging (T.P.M.) and Medicine (L.D.D.), Rhode Island Hospital, Providence; Alpert Medical School of Brown University, Providence, RI (T.P.M., L.D.D.); Department of Medicine, University of Toledo, OH (C.J.C.); Departments of Statistics (K.M.P., R.B.D, J.M.M.), Medicine (D.E.C.), and Biostatistics (Q.G.), Harvard Clinical Research Institute, Boston, MA; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.E.C.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Medicine, University of Michigan, Ann Arbor (K.J.); Department of Radiology, University of Virginia, Charlottesville (A.H.M.); Department of Medicine, University of Texas Health Science Center, San Antonio (W.H.); Department of Medicine, Marshall University, Huntington, WV (J.I.S.); Department of Medicine, Providence Health Care and University of Washington School of Medicine, Spokane (K.R.T.); Department of Medicine, St. Luke's Hospital, Kansas City, MO (D.J.C.); Departments of Pathology (M.S.) and Medicine (A.H.), The University of Minnesota Medical School, Minneapolis; Department of Medicine, Wellmont-Holston Valley Medical Center, Kingsport, TN (D.C.M.); Department of Medicine, Asheville Cardiology Associates, NC (W.B.A.); Department of Medicine, Mayo Clinic, Rochester, MN (S.C.T.); Department of Radiology, Lancaster General Hospital, PA (J.B.); and Department of Medicine, Sunnybrook Research Institute (S.T.), Toronto, Ontario, Canada.
authors.forename: Donald E
authors.initials: DE
authors.lastname: Cutlip
authors.affiliation: From the Departments of Diagnostic Imaging (T.P.M.) and Medicine (L.D.D.), Rhode Island Hospital, Providence; Alpert Medical School of Brown University, Providence, RI (T.P.M., L.D.D.); Department of Medicine, University of Toledo, OH (C.J.C.); Departments of Statistics (K.M.P., R.B.D, J.M.M.), Medicine (D.E.C.), and Biostatistics (Q.G.), Harvard Clinical Research Institute, Boston, MA; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.E.C.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Medicine, University of Michigan, Ann Arbor (K.J.); Department of Radiology, University of Virginia, Charlottesville (A.H.M.); Department of Medicine, University of Texas Health Science Center, San Antonio (W.H.); Department of Medicine, Marshall University, Huntington, WV (J.I.S.); Department of Medicine, Providence Health Care and University of Washington School of Medicine, Spokane (K.R.T.); Department of Medicine, St. Luke's Hospital, Kansas City, MO (D.J.C.); Departments of Pathology (M.S.) and Medicine (A.H.), The University of Minnesota Medical School, Minneapolis; Department of Medicine, Wellmont-Holston Valley Medical Center, Kingsport, TN (D.C.M.); Department of Medicine, Asheville Cardiology Associates, NC (W.B.A.); Department of Medicine, Mayo Clinic, Rochester, MN (S.C.T.); Department of Radiology, Lancaster General Hospital, PA (J.B.); and Department of Medicine, Sunnybrook Research Institute (S.T.), Toronto, Ontario, Canada.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Jamerson
authors.affiliation: From the Departments of Diagnostic Imaging (T.P.M.) and Medicine (L.D.D.), Rhode Island Hospital, Providence; Alpert Medical School of Brown University, Providence, RI (T.P.M., L.D.D.); Department of Medicine, University of Toledo, OH (C.J.C.); Departments of Statistics (K.M.P., R.B.D, J.M.M.), Medicine (D.E.C.), and Biostatistics (Q.G.), Harvard Clinical Research Institute, Boston, MA; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.E.C.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Medicine, University of Michigan, Ann Arbor (K.J.); Department of Radiology, University of Virginia, Charlottesville (A.H.M.); Department of Medicine, University of Texas Health Science Center, San Antonio (W.H.); Department of Medicine, Marshall University, Huntington, WV (J.I.S.); Department of Medicine, Providence Health Care and University of Washington School of Medicine, Spokane (K.R.T.); Department of Medicine, St. Luke's Hospital, Kansas City, MO (D.J.C.); Departments of Pathology (M.S.) and Medicine (A.H.), The University of Minnesota Medical School, Minneapolis; Department of Medicine, Wellmont-Holston Valley Medical Center, Kingsport, TN (D.C.M.); Department of Medicine, Asheville Cardiology Associates, NC (W.B.A.); Department of Medicine, Mayo Clinic, Rochester, MN (S.C.T.); Department of Radiology, Lancaster General Hospital, PA (J.B.); and Department of Medicine, Sunnybrook Research Institute (S.T.), Toronto, Ontario, Canada.
authors.forename: Alan H
authors.initials: AH
authors.lastname: Matsumoto
authors.affiliation: From the Departments of Diagnostic Imaging (T.P.M.) and Medicine (L.D.D.), Rhode Island Hospital, Providence; Alpert Medical School of Brown University, Providence, RI (T.P.M., L.D.D.); Department of Medicine, University of Toledo, OH (C.J.C.); Departments of Statistics (K.M.P., R.B.D, J.M.M.), Medicine (D.E.C.), and Biostatistics (Q.G.), Harvard Clinical Research Institute, Boston, MA; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.E.C.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Medicine, University of Michigan, Ann Arbor (K.J.); Department of Radiology, University of Virginia, Charlottesville (A.H.M.); Department of Medicine, University of Texas Health Science Center, San Antonio (W.H.); Department of Medicine, Marshall University, Huntington, WV (J.I.S.); Department of Medicine, Providence Health Care and University of Washington School of Medicine, Spokane (K.R.T.); Department of Medicine, St. Luke's Hospital, Kansas City, MO (D.J.C.); Departments of Pathology (M.S.) and Medicine (A.H.), The University of Minnesota Medical School, Minneapolis; Department of Medicine, Wellmont-Holston Valley Medical Center, Kingsport, TN (D.C.M.); Department of Medicine, Asheville Cardiology Associates, NC (W.B.A.); Department of Medicine, Mayo Clinic, Rochester, MN (S.C.T.); Department of Radiology, Lancaster General Hospital, PA (J.B.); and Department of Medicine, Sunnybrook Research Institute (S.T.), Toronto, Ontario, Canada.
authors.forename: William
authors.initials: W
authors.lastname: Henrich
authors.affiliation: From the Departments of Diagnostic Imaging (T.P.M.) and Medicine (L.D.D.), Rhode Island Hospital, Providence; Alpert Medical School of Brown University, Providence, RI (T.P.M., L.D.D.); Department of Medicine, University of Toledo, OH (C.J.C.); Departments of Statistics (K.M.P., R.B.D, J.M.M.), Medicine (D.E.C.), and Biostatistics (Q.G.), Harvard Clinical Research Institute, Boston, MA; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.E.C.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Medicine, University of Michigan, Ann Arbor (K.J.); Department of Radiology, University of Virginia, Charlottesville (A.H.M.); Department of Medicine, University of Texas Health Science Center, San Antonio (W.H.); Department of Medicine, Marshall University, Huntington, WV (J.I.S.); Department of Medicine, Providence Health Care and University of Washington School of Medicine, Spokane (K.R.T.); Department of Medicine, St. Luke's Hospital, Kansas City, MO (D.J.C.); Departments of Pathology (M.S.) and Medicine (A.H.), The University of Minnesota Medical School, Minneapolis; Department of Medicine, Wellmont-Holston Valley Medical Center, Kingsport, TN (D.C.M.); Department of Medicine, Asheville Cardiology Associates, NC (W.B.A.); Department of Medicine, Mayo Clinic, Rochester, MN (S.C.T.); Department of Radiology, Lancaster General Hospital, PA (J.B.); and Department of Medicine, Sunnybrook Research Institute (S.T.), Toronto, Ontario, Canada.
authors.forename: Joseph I
authors.initials: JI
authors.lastname: Shapiro
authors.affiliation: From the Departments of Diagnostic Imaging (T.P.M.) and Medicine (L.D.D.), Rhode Island Hospital, Providence; Alpert Medical School of Brown University, Providence, RI (T.P.M., L.D.D.); Department of Medicine, University of Toledo, OH (C.J.C.); Departments of Statistics (K.M.P., R.B.D, J.M.M.), Medicine (D.E.C.), and Biostatistics (Q.G.), Harvard Clinical Research Institute, Boston, MA; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.E.C.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Medicine, University of Michigan, Ann Arbor (K.J.); Department of Radiology, University of Virginia, Charlottesville (A.H.M.); Department of Medicine, University of Texas Health Science Center, San Antonio (W.H.); Department of Medicine, Marshall University, Huntington, WV (J.I.S.); Department of Medicine, Providence Health Care and University of Washington School of Medicine, Spokane (K.R.T.); Department of Medicine, St. Luke's Hospital, Kansas City, MO (D.J.C.); Departments of Pathology (M.S.) and Medicine (A.H.), The University of Minnesota Medical School, Minneapolis; Department of Medicine, Wellmont-Holston Valley Medical Center, Kingsport, TN (D.C.M.); Department of Medicine, Asheville Cardiology Associates, NC (W.B.A.); Department of Medicine, Mayo Clinic, Rochester, MN (S.C.T.); Department of Radiology, Lancaster General Hospital, PA (J.B.); and Department of Medicine, Sunnybrook Research Institute (S.T.), Toronto, Ontario, Canada.
authors.forename: Katherine R
authors.initials: KR
authors.lastname: Tuttle
authors.affiliation: From the Departments of Diagnostic Imaging (T.P.M.) and Medicine (L.D.D.), Rhode Island Hospital, Providence; Alpert Medical School of Brown University, Providence, RI (T.P.M., L.D.D.); Department of Medicine, University of Toledo, OH (C.J.C.); Departments of Statistics (K.M.P., R.B.D, J.M.M.), Medicine (D.E.C.), and Biostatistics (Q.G.), Harvard Clinical Research Institute, Boston, MA; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.E.C.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Medicine, University of Michigan, Ann Arbor (K.J.); Department of Radiology, University of Virginia, Charlottesville (A.H.M.); Department of Medicine, University of Texas Health Science Center, San Antonio (W.H.); Department of Medicine, Marshall University, Huntington, WV (J.I.S.); Department of Medicine, Providence Health Care and University of Washington School of Medicine, Spokane (K.R.T.); Department of Medicine, St. Luke's Hospital, Kansas City, MO (D.J.C.); Departments of Pathology (M.S.) and Medicine (A.H.), The University of Minnesota Medical School, Minneapolis; Department of Medicine, Wellmont-Holston Valley Medical Center, Kingsport, TN (D.C.M.); Department of Medicine, Asheville Cardiology Associates, NC (W.B.A.); Department of Medicine, Mayo Clinic, Rochester, MN (S.C.T.); Department of Radiology, Lancaster General Hospital, PA (J.B.); and Department of Medicine, Sunnybrook Research Institute (S.T.), Toronto, Ontario, Canada.
authors.forename: David J
authors.initials: DJ
authors.lastname: Cohen
authors.affiliation: From the Departments of Diagnostic Imaging (T.P.M.) and Medicine (L.D.D.), Rhode Island Hospital, Providence; Alpert Medical School of Brown University, Providence, RI (T.P.M., L.D.D.); Department of Medicine, University of Toledo, OH (C.J.C.); Departments of Statistics (K.M.P., R.B.D, J.M.M.), Medicine (D.E.C.), and Biostatistics (Q.G.), Harvard Clinical Research Institute, Boston, MA; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.E.C.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Medicine, University of Michigan, Ann Arbor (K.J.); Department of Radiology, University of Virginia, Charlottesville (A.H.M.); Department of Medicine, University of Texas Health Science Center, San Antonio (W.H.); Department of Medicine, Marshall University, Huntington, WV (J.I.S.); Department of Medicine, Providence Health Care and University of Washington School of Medicine, Spokane (K.R.T.); Department of Medicine, St. Luke's Hospital, Kansas City, MO (D.J.C.); Departments of Pathology (M.S.) and Medicine (A.H.), The University of Minnesota Medical School, Minneapolis; Department of Medicine, Wellmont-Holston Valley Medical Center, Kingsport, TN (D.C.M.); Department of Medicine, Asheville Cardiology Associates, NC (W.B.A.); Department of Medicine, Mayo Clinic, Rochester, MN (S.C.T.); Department of Radiology, Lancaster General Hospital, PA (J.B.); and Department of Medicine, Sunnybrook Research Institute (S.T.), Toronto, Ontario, Canada.
authors.forename: Michael
authors.initials: M
authors.lastname: Steffes
authors.affiliation: From the Departments of Diagnostic Imaging (T.P.M.) and Medicine (L.D.D.), Rhode Island Hospital, Providence; Alpert Medical School of Brown University, Providence, RI (T.P.M., L.D.D.); Department of Medicine, University of Toledo, OH (C.J.C.); Departments of Statistics (K.M.P., R.B.D, J.M.M.), Medicine (D.E.C.), and Biostatistics (Q.G.), Harvard Clinical Research Institute, Boston, MA; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.E.C.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Medicine, University of Michigan, Ann Arbor (K.J.); Department of Radiology, University of Virginia, Charlottesville (A.H.M.); Department of Medicine, University of Texas Health Science Center, San Antonio (W.H.); Department of Medicine, Marshall University, Huntington, WV (J.I.S.); Department of Medicine, Providence Health Care and University of Washington School of Medicine, Spokane (K.R.T.); Department of Medicine, St. Luke's Hospital, Kansas City, MO (D.J.C.); Departments of Pathology (M.S.) and Medicine (A.H.), The University of Minnesota Medical School, Minneapolis; Department of Medicine, Wellmont-Holston Valley Medical Center, Kingsport, TN (D.C.M.); Department of Medicine, Asheville Cardiology Associates, NC (W.B.A.); Department of Medicine, Mayo Clinic, Rochester, MN (S.C.T.); Department of Radiology, Lancaster General Hospital, PA (J.B.); and Department of Medicine, Sunnybrook Research Institute (S.T.), Toronto, Ontario, Canada.
authors.forename: Qi
authors.initials: Q
authors.lastname: Gao
authors.affiliation: From the Departments of Diagnostic Imaging (T.P.M.) and Medicine (L.D.D.), Rhode Island Hospital, Providence; Alpert Medical School of Brown University, Providence, RI (T.P.M., L.D.D.); Department of Medicine, University of Toledo, OH (C.J.C.); Departments of Statistics (K.M.P., R.B.D, J.M.M.), Medicine (D.E.C.), and Biostatistics (Q.G.), Harvard Clinical Research Institute, Boston, MA; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.E.C.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Medicine, University of Michigan, Ann Arbor (K.J.); Department of Radiology, University of Virginia, Charlottesville (A.H.M.); Department of Medicine, University of Texas Health Science Center, San Antonio (W.H.); Department of Medicine, Marshall University, Huntington, WV (J.I.S.); Department of Medicine, Providence Health Care and University of Washington School of Medicine, Spokane (K.R.T.); Department of Medicine, St. Luke's Hospital, Kansas City, MO (D.J.C.); Departments of Pathology (M.S.) and Medicine (A.H.), The University of Minnesota Medical School, Minneapolis; Department of Medicine, Wellmont-Holston Valley Medical Center, Kingsport, TN (D.C.M.); Department of Medicine, Asheville Cardiology Associates, NC (W.B.A.); Department of Medicine, Mayo Clinic, Rochester, MN (S.C.T.); Department of Radiology, Lancaster General Hospital, PA (J.B.); and Department of Medicine, Sunnybrook Research Institute (S.T.), Toronto, Ontario, Canada.
authors.forename: D Christopher
authors.initials: DC
authors.lastname: Metzger
authors.affiliation: From the Departments of Diagnostic Imaging (T.P.M.) and Medicine (L.D.D.), Rhode Island Hospital, Providence; Alpert Medical School of Brown University, Providence, RI (T.P.M., L.D.D.); Department of Medicine, University of Toledo, OH (C.J.C.); Departments of Statistics (K.M.P., R.B.D, J.M.M.), Medicine (D.E.C.), and Biostatistics (Q.G.), Harvard Clinical Research Institute, Boston, MA; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.E.C.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Medicine, University of Michigan, Ann Arbor (K.J.); Department of Radiology, University of Virginia, Charlottesville (A.H.M.); Department of Medicine, University of Texas Health Science Center, San Antonio (W.H.); Department of Medicine, Marshall University, Huntington, WV (J.I.S.); Department of Medicine, Providence Health Care and University of Washington School of Medicine, Spokane (K.R.T.); Department of Medicine, St. Luke's Hospital, Kansas City, MO (D.J.C.); Departments of Pathology (M.S.) and Medicine (A.H.), The University of Minnesota Medical School, Minneapolis; Department of Medicine, Wellmont-Holston Valley Medical Center, Kingsport, TN (D.C.M.); Department of Medicine, Asheville Cardiology Associates, NC (W.B.A.); Department of Medicine, Mayo Clinic, Rochester, MN (S.C.T.); Department of Radiology, Lancaster General Hospital, PA (J.B.); and Department of Medicine, Sunnybrook Research Institute (S.T.), Toronto, Ontario, Canada.
authors.forename: William B
authors.initials: WB
authors.lastname: Abernethy
authors.affiliation: From the Departments of Diagnostic Imaging (T.P.M.) and Medicine (L.D.D.), Rhode Island Hospital, Providence; Alpert Medical School of Brown University, Providence, RI (T.P.M., L.D.D.); Department of Medicine, University of Toledo, OH (C.J.C.); Departments of Statistics (K.M.P., R.B.D, J.M.M.), Medicine (D.E.C.), and Biostatistics (Q.G.), Harvard Clinical Research Institute, Boston, MA; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.E.C.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Medicine, University of Michigan, Ann Arbor (K.J.); Department of Radiology, University of Virginia, Charlottesville (A.H.M.); Department of Medicine, University of Texas Health Science Center, San Antonio (W.H.); Department of Medicine, Marshall University, Huntington, WV (J.I.S.); Department of Medicine, Providence Health Care and University of Washington School of Medicine, Spokane (K.R.T.); Department of Medicine, St. Luke's Hospital, Kansas City, MO (D.J.C.); Departments of Pathology (M.S.) and Medicine (A.H.), The University of Minnesota Medical School, Minneapolis; Department of Medicine, Wellmont-Holston Valley Medical Center, Kingsport, TN (D.C.M.); Department of Medicine, Asheville Cardiology Associates, NC (W.B.A.); Department of Medicine, Mayo Clinic, Rochester, MN (S.C.T.); Department of Radiology, Lancaster General Hospital, PA (J.B.); and Department of Medicine, Sunnybrook Research Institute (S.T.), Toronto, Ontario, Canada.
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Textor
authors.affiliation: From the Departments of Diagnostic Imaging (T.P.M.) and Medicine (L.D.D.), Rhode Island Hospital, Providence; Alpert Medical School of Brown University, Providence, RI (T.P.M., L.D.D.); Department of Medicine, University of Toledo, OH (C.J.C.); Departments of Statistics (K.M.P., R.B.D, J.M.M.), Medicine (D.E.C.), and Biostatistics (Q.G.), Harvard Clinical Research Institute, Boston, MA; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.E.C.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Medicine, University of Michigan, Ann Arbor (K.J.); Department of Radiology, University of Virginia, Charlottesville (A.H.M.); Department of Medicine, University of Texas Health Science Center, San Antonio (W.H.); Department of Medicine, Marshall University, Huntington, WV (J.I.S.); Department of Medicine, Providence Health Care and University of Washington School of Medicine, Spokane (K.R.T.); Department of Medicine, St. Luke's Hospital, Kansas City, MO (D.J.C.); Departments of Pathology (M.S.) and Medicine (A.H.), The University of Minnesota Medical School, Minneapolis; Department of Medicine, Wellmont-Holston Valley Medical Center, Kingsport, TN (D.C.M.); Department of Medicine, Asheville Cardiology Associates, NC (W.B.A.); Department of Medicine, Mayo Clinic, Rochester, MN (S.C.T.); Department of Radiology, Lancaster General Hospital, PA (J.B.); and Department of Medicine, Sunnybrook Research Institute (S.T.), Toronto, Ontario, Canada.
authors.forename: John
authors.initials: J
authors.lastname: Briguglio
authors.affiliation: From the Departments of Diagnostic Imaging (T.P.M.) and Medicine (L.D.D.), Rhode Island Hospital, Providence; Alpert Medical School of Brown University, Providence, RI (T.P.M., L.D.D.); Department of Medicine, University of Toledo, OH (C.J.C.); Departments of Statistics (K.M.P., R.B.D, J.M.M.), Medicine (D.E.C.), and Biostatistics (Q.G.), Harvard Clinical Research Institute, Boston, MA; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.E.C.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Medicine, University of Michigan, Ann Arbor (K.J.); Department of Radiology, University of Virginia, Charlottesville (A.H.M.); Department of Medicine, University of Texas Health Science Center, San Antonio (W.H.); Department of Medicine, Marshall University, Huntington, WV (J.I.S.); Department of Medicine, Providence Health Care and University of Washington School of Medicine, Spokane (K.R.T.); Department of Medicine, St. Luke's Hospital, Kansas City, MO (D.J.C.); Departments of Pathology (M.S.) and Medicine (A.H.), The University of Minnesota Medical School, Minneapolis; Department of Medicine, Wellmont-Holston Valley Medical Center, Kingsport, TN (D.C.M.); Department of Medicine, Asheville Cardiology Associates, NC (W.B.A.); Department of Medicine, Mayo Clinic, Rochester, MN (S.C.T.); Department of Radiology, Lancaster General Hospital, PA (J.B.); and Department of Medicine, Sunnybrook Research Institute (S.T.), Toronto, Ontario, Canada.
authors.forename: Alan T
authors.initials: AT
authors.lastname: Hirsch
authors.affiliation: From the Departments of Diagnostic Imaging (T.P.M.) and Medicine (L.D.D.), Rhode Island Hospital, Providence; Alpert Medical School of Brown University, Providence, RI (T.P.M., L.D.D.); Department of Medicine, University of Toledo, OH (C.J.C.); Departments of Statistics (K.M.P., R.B.D, J.M.M.), Medicine (D.E.C.), and Biostatistics (Q.G.), Harvard Clinical Research Institute, Boston, MA; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.E.C.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Medicine, University of Michigan, Ann Arbor (K.J.); Department of Radiology, University of Virginia, Charlottesville (A.H.M.); Department of Medicine, University of Texas Health Science Center, San Antonio (W.H.); Department of Medicine, Marshall University, Huntington, WV (J.I.S.); Department of Medicine, Providence Health Care and University of Washington School of Medicine, Spokane (K.R.T.); Department of Medicine, St. Luke's Hospital, Kansas City, MO (D.J.C.); Departments of Pathology (M.S.) and Medicine (A.H.), The University of Minnesota Medical School, Minneapolis; Department of Medicine, Wellmont-Holston Valley Medical Center, Kingsport, TN (D.C.M.); Department of Medicine, Asheville Cardiology Associates, NC (W.B.A.); Department of Medicine, Mayo Clinic, Rochester, MN (S.C.T.); Department of Radiology, Lancaster General Hospital, PA (J.B.); and Department of Medicine, Sunnybrook Research Institute (S.T.), Toronto, Ontario, Canada.
authors.forename: Sheldon
authors.initials: S
authors.lastname: Tobe
authors.affiliation: From the Departments of Diagnostic Imaging (T.P.M.) and Medicine (L.D.D.), Rhode Island Hospital, Providence; Alpert Medical School of Brown University, Providence, RI (T.P.M., L.D.D.); Department of Medicine, University of Toledo, OH (C.J.C.); Departments of Statistics (K.M.P., R.B.D, J.M.M.), Medicine (D.E.C.), and Biostatistics (Q.G.), Harvard Clinical Research Institute, Boston, MA; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.E.C.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Medicine, University of Michigan, Ann Arbor (K.J.); Department of Radiology, University of Virginia, Charlottesville (A.H.M.); Department of Medicine, University of Texas Health Science Center, San Antonio (W.H.); Department of Medicine, Marshall University, Huntington, WV (J.I.S.); Department of Medicine, Providence Health Care and University of Washington School of Medicine, Spokane (K.R.T.); Department of Medicine, St. Luke's Hospital, Kansas City, MO (D.J.C.); Departments of Pathology (M.S.) and Medicine (A.H.), The University of Minnesota Medical School, Minneapolis; Department of Medicine, Wellmont-Holston Valley Medical Center, Kingsport, TN (D.C.M.); Department of Medicine, Asheville Cardiology Associates, NC (W.B.A.); Department of Medicine, Mayo Clinic, Rochester, MN (S.C.T.); Department of Radiology, Lancaster General Hospital, PA (J.B.); and Department of Medicine, Sunnybrook Research Institute (S.T.), Toronto, Ontario, Canada.
authors.forename: Lance D
authors.initials: LD
authors.lastname: Dworkin
mesh_terms: D000368:Aged; D000419:Albuminuria / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D015897:Comorbidity; D016001:Confidence Intervals; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012078:Renal Artery Obstruction / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy*; D018570:Risk Assessment; D012720:Severity of Illness Index; D015607:Stents; D015996:Survival Rate; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D014665:Vasodilator Agents
keywords: arteriosclerosis; myocardial infarction; renal artery obstruction; renal insufficiency; stents; stroke