title: Catalytic C-H Arylation of Aliphatic Aldehydes Enabled by a Transient Ligand.
abstract: The direct arylation of aliphatic aldehydes has been established via Pd-catalyzed sp3C-H bond functionalization in the presence of 3-aminopropanoic acids as transient directing groups. The reaction showed excellent functional group compatibility and chemoselectivity in which a predominant preference for functionalizing unactivated β-C-H bonds of methyl groups over others was achieved. In addition, C-H bonds of unactivated secondary sp3carbons can also be functionalized. The extreme popularity and importance of aliphatic aldehydes would result in broad applications of this novel method in organic chemistry and medicinal sciences.
authors.affiliation: Institute of Chemistry & BioMedical Sciences, Collaborative Innovation Center of Chemistry for Life Sciences, Nanjing University , Nanjing 210093, P. R. China.|Department of Chemistry and Chemical Biology, Indiana University-Purdue University Indianapolis , Indianapolis, Indiana 46202, United States.
authors.forename: Ke
authors.initials: K
authors.lastname: Yang
authors.affiliation: Institute of Chemistry & BioMedical Sciences, Collaborative Innovation Center of Chemistry for Life Sciences, Nanjing University , Nanjing 210093, P. R. China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Chemistry and Chemical Biology, Indiana University-Purdue University Indianapolis , Indianapolis, Indiana 46202, United States.
authors.forename: Yongbing
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Institute of Chemistry & BioMedical Sciences, Collaborative Innovation Center of Chemistry for Life Sciences, Nanjing University , Nanjing 210093, P. R. China.|Department of Chemistry and Biochemistry, Texas Tech University , Lubbock, Texas 79409-1061, United States.
authors.forename: Guigen
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Chemistry and Chemical Biology, Indiana University-Purdue University Indianapolis , Indianapolis, Indiana 46202, United States.
authors.forename: Haibo
authors.initials: H
authors.lastname: Ge