title: Adiponectin and Cardiac Hypertrophy in Acromegaly.
abstract: BACKGROUND
  Adiponectin is an adipocytes-derived hormone which has been shown to possess insulin-sensitizing, antiatherogenic, and anti-inflammatory properties. In acromegaly, the data on adiponectin is contradictory. The relationship between adiponectin levels and cardiac parameters has not been studied.
  
  
  OBJECTIVE
  The aim of this study was to find out how adiponectin levels were affected in acromegalic patients and the relationship between adiponectin levels and cardiac parameters.
  
  
  METHODS
  We included 30 subjects (15 male, 15 female), diagnosed with acromegaly and 30 healthy (10 male, 20 female) subjects. Serum glucose, insulin, GH, IGF-1 and adiponectin levels were obtained and the insulin resistance of the subjects was calculated. Echocardiographic studies of the subjects were performed.
  
  
  RESULTS
  We determined that adiponectin levels were significantly higher in the acromegalic group than the control group. In the acromegalic group, there was no statistically significant relation between serum adiponectin and growth hormone (GH), or insulin-like growth factor-1 (IGF-1) levels (p = 0.3, p = 0.1). We demonstrated that cardiac function and structure are affected by acromegaly. IVST, PWT, LVMI, E/A ratio, DT, ET, IVRT, VPR, and LVESV values were increased and the results were statistically significant. In the acromegalic group, adiponectin levels were positively related with left ventricle mass index (LVMI) but this correlation was found to be statistically weak (p = 0.03). In our study, there was a positive correlation between VAI and LVM. We also could not find any correlation between VAI and adiponectin levels.
  
  
  CONCLUSIONS
  Although insulin resistance and high insulin levels occur in active acromegaly patients, adiponectin levels were higher in our study as a consequence of GH lowering therapies. Our study showed that adiponectin levels may be an indicator of the cardiac involvement acromegaly. However, the usage of serum adiponectin levels in acromegalic patients as an indicator of cardiac involvement should be supported with other, wide, multi-centered studies.
authors.affiliation: Department of Internal Medicine, Pamukkale University, Turkey.
authors.forename: Sabriye
authors.initials: S
authors.lastname: Gurbulak
authors.affiliation: Department of Endocrinology, Pamukkale University, Turkey.
authors.forename: Fulya
authors.initials: F
authors.lastname: Akin
authors.affiliation: Department of Endocrinology, Denizli State Hospital, Turkey.
authors.forename: Emrah
authors.initials: E
authors.lastname: Yerlikaya
authors.affiliation: Department of Endocrinology, Pamukkale University, Turkey.
authors.forename: Guzin F
authors.initials: GF
authors.lastname: Yaylali
authors.affiliation: Department of Endocrinology, Pamukkale University, Turkey.
authors.forename: Senay
authors.initials: S
authors.lastname: Topsakal
authors.affiliation: Department of Cardiology, Pamukkale University, Turkey.
authors.forename: Halil
authors.initials: H
authors.lastname: Tanriverdi
authors.affiliation: Department of Biostatistics, Pamukkale University, Turkey.
authors.forename: Beyza
authors.initials: B
authors.lastname: Akdag
authors.affiliation: Department of Biochemistry, Pamukkale University, Turkey.
authors.forename: Bunyamin
authors.initials: B
authors.lastname: Kaptanoglu
mesh_terms: D000172:Acromegaly / Q000097:blood* / Q000503:physiopathology; D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000704:Analysis of Variance; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D006332:Cardiomegaly / Q000097:blood* / Q000503:physiopathology; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D050152:Intra-Abdominal Fat / Q000378:metabolism; D008297:Male; D008875:Middle Aged
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone
keywords: acromegaly; adiponectin; cardiac hypertrophy; echocardiography; insulin resistance