title: Research Advance in Intestinal Mucosal Barrier and Pathogenesis of Crohn's Disease.
abstract: To date, the etiology and pathogenesis of Crohn's disease (CD) have not been fully elucidated. It is widely accepted that genetic, immune, and environment factors are closely related to the development of CD. As an important defensive line for human body against the environment, intestinal mucosa is able to protect the homeostasis of gut bacteria and alleviate the intestinal inflammatory and immune response. It is evident that the dysfunction of intestinal mucosa barriers plays a crucial role in CD initiation and development. Yet researches are insufficient on intestinal mucosal barrier's action in the prevention of CD onset. This article summarizes the research advances about the correlations between the disorders of intestinal mucosal barriers and CD.
authors.affiliation: Shanghai Institute of Acupuncture-Moxibustion and Meridian, Shanghai 200030, China.
authors.forename: Kuan
authors.identifier: 0000-0002-8282-2002
authors.initials: K
authors.lastname: Wang
authors.affiliation: Shanghai Institute of Acupuncture-Moxibustion and Meridian, Shanghai 200030, China.
authors.forename: Lu-Yi
authors.identifier: 0000-0001-8888-1698
authors.initials: LY
authors.lastname: Wu
authors.affiliation: Shanghai Institute of Acupuncture-Moxibustion and Meridian, Shanghai 200030, China.
authors.forename: Chuan-Zi
authors.initials: CZ
authors.lastname: Dou
authors.affiliation: Shanghai Shuguang Hospital Affiliated with Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Guan
authors.affiliation: Shanghai Institute of Acupuncture-Moxibustion and Meridian, Shanghai 200030, China.
authors.forename: Huan-Gan
authors.initials: HG
authors.lastname: Wu
authors.affiliation: Shanghai Institute of Acupuncture-Moxibustion and Meridian, Shanghai 200030, China.
authors.forename: Hui-Rong
authors.identifier: 0000-0002-5132-1141
authors.initials: HR
authors.lastname: Liu