title: Two new prenylated isoflavones from Hedysarum multijugum.
abstract: Chemical investigation on the ethyl acetate extract of the roots of Hedysarum multijugum resulted in the isolation of two new prenylated isoflavonoids: 5, 7, 2'-trihydroxy-4'-methoxy-3'-(γ, γ-dimethylallyl) isoflavone (hedysarimisoflavone A, 1) and 5, 7, 2'-trihydroxy-4'-methoxy-6, 8-di-(γ, γ-dimethylallyl) isoflavone (hedysarimisoflavone B, 2). Their structures were elucidated on the basis of spectroscopic analyses, especially,1H and13C NMR spectra in conjunction with their 2D experiments,1H-1H COSY, HMQC, HMBC, and NOESY.
authors.affiliation: a State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences , Peking University , Beijing 100191 , China.|b State Key Laboratory of Membrane Biology, School of Life Sciences , Tsinghua University , Beijing 100084 , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: a State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences , Peking University , Beijing 100191 , China.
authors.forename: Yu-Ying
authors.initials: YY
authors.lastname: Zhao
authors.affiliation: c School of Chinese Medicine , Hong Kong Baptist University , Hongkong 999077 , China.
authors.forename: Hubiao
authors.initials: H
authors.lastname: Chen
authors.affiliation: a State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences , Peking University , Beijing 100191 , China.
authors.forename: Qing-Ying
authors.initials: QY
authors.lastname: Zhang
authors.affiliation: a State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences , Peking University , Beijing 100191 , China.
authors.forename: Hong
authors.initials: H
authors.lastname: Liang
mesh_terms: D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D007887:Fabaceae / Q000737:chemistry*; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D054876:Prenylation
chemical_list: D004365:Drugs, Chinese Herbal; D007529:Isoflavones; C000617173:hedysarimisoflavone A; C000617174:hedysarimisoflavone B
keywords: Hedysarum multijugum; Leguminosae; hedysarimisoflavone A; hedysarimisoflavone B; isoflavones