title: Targeting Nitric Oxide with Natural Derived Compounds as a Therapeutic Strategy in Vascular Diseases.
abstract: Within the family of endogenous gasotransmitters, nitric oxide (NO) is the smallest gaseous intercellular messenger involved in the modulation of several processes, such as blood flow and platelet aggregation control, essential to maintain vascular homeostasis. NO is produced by nitric oxide synthases (NOS) and its effects are mediated by cGMP-dependent or cGMP-independent mechanisms. Growing evidence suggests a crosstalk between the NO signaling and the occurrence of oxidative stress in the onset and progression of vascular diseases, such as hypertension, heart failure, ischemia, and stroke. For these reasons, NO is considered as an emerging molecular target for developing therapeutic strategies for cardio- and cerebrovascular pathologies. Several natural derived compounds, such as polyphenols, are now proposed as modulators of NO-mediated pathways. The aim of this review is to highlight the experimental evidence on the involvement of nitric oxide in vascular homeostasis focusing on the therapeutic potential of targeting NO with some natural compounds in patients with vascular diseases.
authors.affiliation: IRCCS Neuromed, Vascular Physiopathology Unit, Pozzilli, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Forte
authors.affiliation: Università degli Studi di Salerno, Medicine, Surgery and Dentistry, Baronissi, Italy.
authors.forename: Valeria
authors.identifier: 0000-0001-6964-2739
authors.initials: V
authors.lastname: Conti
authors.affiliation: IRCCS Neuromed, Vascular Physiopathology Unit, Pozzilli, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Damato
authors.affiliation: IRCCS Neuromed, Vascular Physiopathology Unit, Pozzilli, Italy.
authors.forename: Mariateresa
authors.initials: M
authors.lastname: Ambrosio
authors.affiliation: Università degli Studi di Salerno, Medicine, Surgery and Dentistry, Baronissi, Italy; IRCCS Multimedica, Milan, Italy.
authors.forename: Annibale A
authors.initials: AA
authors.lastname: Puca
authors.affiliation: IRCCS Neuromed, Vascular Physiopathology Unit, Pozzilli, Italy; Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy.
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Sciarretta
authors.affiliation: IRCCS Neuromed, Vascular Physiopathology Unit, Pozzilli, Italy; Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Frati
authors.affiliation: IRCCS Neuromed, Vascular Physiopathology Unit, Pozzilli, Italy; Università degli Studi di Salerno, Medicine, Surgery and Dentistry, Baronissi, Italy.
authors.forename: Carmine
authors.initials: C
authors.lastname: Vecchione
authors.affiliation: IRCCS Neuromed, Vascular Physiopathology Unit, Pozzilli, Italy.
authors.forename: Albino
authors.identifier: 0000-0003-2689-0008
authors.initials: A
authors.lastname: Carrizzo
mesh_terms: D000818:Animals; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D002319:Cardiovascular System / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D004032:Diet; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects*; D064209:Phytochemicals / Q000627:therapeutic use*; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use*; D010946:Plants, Medicinal; D059808:Polyphenols / Q000627:therapeutic use*; D015398:Signal Transduction / Q000187:drug effects; D014652:Vascular Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology
chemical_list: D002317:Cardiovascular Agents; D064209:Phytochemicals; D028321:Plant Preparations; D059808:Polyphenols; D009569:Nitric Oxide