title: Change in Trend in Various Clinico-Pathological Factors and Treatment Profile of Breast Cancer Patients: a Tertiary Cancer Centre Experience.
abstract: BACKGROUND
  Breast cancer is by far the most frequent cancer of women (23% of all cancers), ranking second overall when both sexes are considered together. Since there has been change in clinico-pathological factors and treatment profiles for breast cancer patients over the years, the present study to evaluate the change trends in India.
  
  
  METHODS
  A detailed analysis was carried out with respect to age, menopausal status, family history, disease stage, surgery performed, histopathology, hormone receptor status, and use of chemotherapy or hormonal therapy. Change in various clinico-pathological factors and treatments of breast cancer cases was recorded and analysed.
  
  
  RESULTS
  Mean age at presentation was found to be earlier in 2005-2006 compared with 1997-98 (p value: 0.046). More premenopausal women were diagnosed with breast cancer in 2005-2006 when this was compared with initial years of assessment (p value ≤0.001). When change in the receptor status was evaluated, we observed that there was a decrease in cases of ER and PR receptor positivity which was significant (p value: 0.007). Over the period of time, more f patients were not offered surgery initially in view of advanced disease when the two time periods were compared (p value: ≤0.001). There was a significant increase in patients who were initially offered neo-adjuvant chemotherapy in view of advanced disease at presentation (p value: ≤0.001). There was increasing number of patients who received palliative treatment for symptoms in 2005-2006 when compared to patients treated in 1997-98((p value: ≤0.001).
  
  
  CONCLUSIONS
  Changes in mean age at presentation, premenopausal status, and stage at presentation have occurred over the years. More aggressive patterns of disease have become more common with early age at presentation and aggressive biological behaviour with receptor negative tumours.
authors.affiliation: Department of Radiation Oncology, Dr BR Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India E-mail : doc.abhishankar@gmail.com.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Shankar
authors.forename: Shubham
authors.initials: S
authors.lastname: Roy
authors.forename: Gk
authors.initials: G
authors.lastname: Rath
authors.forename: Vineet Kumar
authors.initials: VK
authors.lastname: Kamal
authors.forename: Menal
authors.initials: M
authors.lastname: Bhandari
authors.forename: Rashi
authors.initials: R
authors.lastname: Kulshrestha
authors.forename: Neelam
authors.initials: N
authors.lastname: Prasad
authors.forename: Jaineet
authors.initials: J
authors.lastname: Sachdev
authors.forename: Pamela
authors.initials: P
authors.lastname: Jeyaraj
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology*; D017024:Chemotherapy, Adjuvant / Q000379:methods; D005260:Female; D006801:Humans; D007194:India; D008875:Middle Aged; D017697:Premenopause / Q000187:drug effects; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D062606:Tertiary Care Centers
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone