title: Phage Display Technology in Biomaterials Engineering: Progress and Opportunities for Applications in Regenerative Medicine.
abstract: The field of regenerative medicine has been gaining momentum steadily over the past few years. The emphasis in regenerative medicine is to use various in vitro and in vivo approaches that leverage the intrinsic healing mechanisms of the body to treat patients with disabling injuries and chronic diseases such as diabetes, osteoarthritis, and degenerative disorders of the cardiovascular and central nervous system. Phage display has been successfully employed to identify peptide ligands for a wide variety of targets, ranging from relatively small molecules (enzymes, cell receptors) to inorganic, organic, and biological (tissues) materials. Over the past two decades, phage display technology has advanced tremendously and has become a powerful tool in the most varied fields of research, including biotechnology, materials science, cell biology, pharmacology, and diagnostics. The growing interest in and success of phage display libraries is largely due to its incredible versatility and practical use. This review discusses the potential of phage display technology in biomaterials engineering for applications in regenerative medicine.
authors.affiliation: 3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho , Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4805-717 Barco, Guimarães, Portugal.|ICVS/3B's - PT Government Associate Laboratory , Braga/Guimarães, Portugal.|CEB - Centre of Biological Engineering, University of Minho , 4710-057, Braga, Portugal.
authors.forename: Ivone M
authors.initials: IM
authors.lastname: Martins
authors.affiliation: 3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho , Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4805-717 Barco, Guimarães, Portugal.|ICVS/3B's - PT Government Associate Laboratory , Braga/Guimarães, Portugal.
authors.forename: Rui L
authors.initials: RL
authors.lastname: Reis
authors.affiliation: 3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho , Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4805-717 Barco, Guimarães, Portugal.|ICVS/3B's - PT Government Associate Laboratory , Braga/Guimarães, Portugal.|School of Engineering & Materials Science, Queen Mary University of London , London E1 4NS, United Kingdom.|Institute of Bioengineering, Queen Mary University of London , London E1 4NS, United Kingdom.
authors.forename: Helena S
authors.initials: HS
authors.lastname: Azevedo
mesh_terms: D001435:Bacteriophages / Q000235:genetics*; D001672:Biocompatible Materials; D015316:Genetic Therapy; D008024:Ligands; D019151:Peptide Library; D044968:Regenerative Medicine; D013234:Stem Cells / Q000166:cytology
chemical_list: D001672:Biocompatible Materials; D008024:Ligands; D019151:Peptide Library