title: Prevalence and risk factors of nonalcoholic fatty liver disease in breast cancer patients.
abstract: OBJECTIVE
  We aimed to evaluate the prevalence of nonalcoholic fatty liver disease (NAFLD) in breast cancer patients using liver magnetic resonance imaging (MRI), and to investigate factors associated with NAFLD.
  
  
  METHODS
  We evaluated 104 patients surgically treated for breast cancer at our hospital between September and November 2013. None of the patients had any other causes of secondary hepatic fat accumulation (such as signiﬁcant alcohol consumption, use of steatogenic medication or inborn disorders). Hepatic fat accumulation was measured using liver MRI perfomed in all patients before surgical treatment.
  
  
  RESULTS
  Based on the fat signal percentage from liver MRIs, 19 of 104 breast cancer patients were diagnosed with NAFLD, so the prevalence of NAFLD was 18.3%. In univariate analysis, factors associated with NAFLD were older age, high body mass index, type 2 diabetes mellitus (DM), hypertension, elevated aspartate aminotransferase, elevated alanine aminotransferase and elevated triglycerides (TG). In multivariate analysis, factors associated with NAFLD were high body mass index (BMI) (odds ratio [OR] 1.403; 95% confidence interval [CI] 1.111-1.771; p = 0.005), type 2 DM (OR 11.872; 95% CI 1.065-132.373; p = 0.044), and an elevated TG level (OR 50.267; 95% CI 4.409-573.030; p = 0.002).
  
  
  CONCLUSIONS
  The prevalence of NAFLD in breast cancer patients was not different from that of the general population. High BMI, type 2 DM and an elevated serum TG level were factors associated with NAFLD.
authors.affiliation: Department of Surgery, Biomedical Research Institute, Pusan National University Hospital, Busan - Republic of Korea.
authors.forename: Seokwon
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Surgery, Biomedical Research Institute, Pusan National University Hospital, Busan - Republic of Korea.
authors.forename: Younglae
authors.initials: Y
authors.lastname: Jung
authors.affiliation: Department of Surgery, Biomedical Research Institute, Pusan National University Hospital, Busan - Republic of Korea.
authors.forename: Youngtae
authors.initials: Y
authors.lastname: Bae
authors.affiliation: Department of Surgery, Biomedical Research Institute, Pusan National University Hospital, Busan - Republic of Korea.
authors.forename: Sung Pil
authors.initials: SP
authors.lastname: Yun
authors.affiliation: Department of Radiology, Biomedical Research Institute, Pusan National University Hospital, Busan - Republic of Korea.
authors.forename: Suk
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Surgery, Biomedical Research Institute, Pusan National University Hospital, Busan - Republic of Korea.
authors.forename: Hongjae
authors.initials: H
authors.lastname: Jo
authors.affiliation: Department of Surgery, Biomedical Research Institute, Pusan National University Hospital, Busan - Republic of Korea.
authors.forename: Hyung-Il
authors.initials: HI
authors.lastname: Seo
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000378:metabolism; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D008099:Liver / Q000473:pathology*; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000453:epidemiology* / Q000209:etiology* / Q000473:pathology; D016017:Odds Ratio; D015995:Prevalence; D012307:Risk Factors
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase