title: Pathogenesis of cerebral palsy through the prism of immune regulation of nervous tissue homeostasis: literature review.
abstract: BACKGROUND
  The cerebral palsy is highly actual issue of pediatrics, causing significant neurological disability. Though the great progress in the neuroscience has been recently achieved, the pathogenesis of cerebral palsy is still poorly understood.
  
  
  METHODS
  In this work, we reviewed available experimental and clinical data concerning the role of immune cells in pathogenesis of cerebral palsy. Maintaining of homeostasis in nervous tissue and its transformation in case of periventricular leukomalacia were analyzed.
  
  
  RESULTS
  The reviewed data demonstrate involvement of immune regulatory cells in the formation of nervous tissue imbalance and chronicity of inborn brain damage. The supported opinion, that periventricular leukomalacia is not a static phenomenon, but developing process, encourages our optimism about the possibility of its correction.
  
  
  CONCLUSIONS
  The further studies of changes of the nervous and immune systems in cerebral palsy are needed to create fundamentally new directions of the specific therapy and individual schemes of rehabilitation.
authors.affiliation: Republican Children's Rehabilitation Center, Turan str., 36, Astana, Kazakhstan, 010000. lisovska67@mail.ru.
authors.forename: Natalya
authors.initials: N
authors.lastname: Lisovska
authors.affiliation: Republican Children's Rehabilitation Center, Turan str., 36, Astana, Kazakhstan, 010000.
authors.forename: Zholtay
authors.initials: Z
authors.lastname: Daribayev
authors.affiliation: Republican Children's Rehabilitation Center, Turan str., 36, Astana, Kazakhstan, 010000.
authors.forename: Yevgeny
authors.initials: Y
authors.lastname: Lisovskyy
authors.affiliation: Republican Children's Rehabilitation Center, Turan str., 36, Astana, Kazakhstan, 010000.
authors.forename: Kenzhe
authors.initials: K
authors.lastname: Kussainova
authors.affiliation: Department of Pediatrics, Parirenyatwa Group of hospitals, Harare, Zimbabwe.
authors.forename: Lana
authors.initials: L
authors.lastname: Austin
authors.affiliation: Republican Children's Rehabilitation Center, Turan str., 36, Astana, Kazakhstan, 010000.
authors.forename: Sholpan
authors.initials: S
authors.lastname: Bulekbayeva
mesh_terms: D002547:Cerebral Palsy / Q000276:immunology* / Q000503:physiopathology*; D006706:Homeostasis; D006801:Humans; D007969:Leukomalacia, Periventricular / Q000276:immunology / Q000503:physiopathology*; D009420:Nervous System / Q000276:immunology* / Q000503:physiopathology*
keywords: Cerebral palsy; Immune cells; Periventricular leukomalacia; Tissue homeostasis