title: Newly identified poor prognostic factors for adult T-cell leukemia-lymphoma treated with allogeneic hematopoietic stem cell transplantation.
abstract: To explore pre-transplantation prognostic factors for adult T-cell leukemia-lymphoma (ATL), we retrospectively analyzed allogeneic hematopoietic stem cell transplantation (allo-HSCT) in 70 patients at our institute (63 acute type and seven lymphoma type patients). Forty-five patients died after HSCT and the three-year overall survival (OS) rate was 35.2%. By univariate analysis, the adverse prognostic factors for OS were performance status ≥2, hematopoietic cell transplantation-specific comorbidity index (HCT-CI) score ≥3, European Group for Blood and Marrow Transplantation (EBMT) risk score ≥5, HSCT from an HLA-mismatched donor, serum soluble interleukin-2 receptor (sIL-2R) level ≥10,000 U/mL, lymphocyte count ≥4000/μL, and hemoglobin <9 g/dL at the time of HSCT. EBMT risk score and sIL-2R were identified as significant adverse prognostic factors using multivariate analysis. This analysis clearly demonstrates for the first time that HCT-CI and EBMT risk scores are reliable prognostic factors for ATL patients receiving allo-HSCT.
authors.affiliation: a Department of Hematology , Imamura Bun-in Hospital , Kagoshima , Japan.|b Digestive Disease and Life-Style Related Disease , Kagoshima University Graduate School of Medical and Dental Sciences , Kagoshima , Japan.
authors.forename: Masahito
authors.initials: M
authors.lastname: Tokunaga
authors.affiliation: b Digestive Disease and Life-Style Related Disease , Kagoshima University Graduate School of Medical and Dental Sciences , Kagoshima , Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Uto
authors.affiliation: a Department of Hematology , Imamura Bun-in Hospital , Kagoshima , Japan.
authors.forename: Shogo
authors.initials: S
authors.lastname: Takeuchi
authors.affiliation: a Department of Hematology , Imamura Bun-in Hospital , Kagoshima , Japan.
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Nakano
authors.affiliation: a Department of Hematology , Imamura Bun-in Hospital , Kagoshima , Japan.
authors.forename: Ayumu
authors.initials: A
authors.lastname: Kubota
authors.affiliation: a Department of Hematology , Imamura Bun-in Hospital , Kagoshima , Japan.|b Digestive Disease and Life-Style Related Disease , Kagoshima University Graduate School of Medical and Dental Sciences , Kagoshima , Japan.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Tokunaga
authors.affiliation: a Department of Hematology , Imamura Bun-in Hospital , Kagoshima , Japan.
authors.forename: Yoshifusa
authors.initials: Y
authors.lastname: Takatsuka
authors.affiliation: c Department of Pathology , Kurume University School of Medicine , Fukuoka , Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Seto
authors.affiliation: b Digestive Disease and Life-Style Related Disease , Kagoshima University Graduate School of Medical and Dental Sciences , Kagoshima , Japan.
authors.forename: Akio
authors.initials: A
authors.lastname: Ido
authors.affiliation: a Department of Hematology , Imamura Bun-in Hospital , Kagoshima , Japan.
authors.forename: Atae
authors.initials: A
authors.lastname: Utsunomiya
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000453:epidemiology / Q000401:mortality* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D012074:Remission Induction; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D055815:Young Adult
keywords: Adult T-cell leukemia-lymphoma; European Group for Blood and Marrow Transplantation risk score; allogeneic hematopoietic stem cell transplantation; hematopoietic cell transplantation-specific comorbidity index; prognostic factor