title: Fatty acids profile in preterm Colostrum of Tunisian women. Association with selected maternal characteristics.
abstract: Fatty acids (FA), especially arachidonic (AA, 20:4ω6) and docosahexaenoic (DHA, 22:6ω3) acids are critical for the health and development of infants. Colostrum FA composition has been examined in 101 lactating Tunisian women delivering prematurely using gas chromatography. Among polyunsaturated FA, linoleic acid predominated whereas each of the other polyunsaturated FA accounted for 1% or less of total FA. Colostrum AA and DHA contents were lower in women aged above 34 years compared to those less than 34 years. Preeclampsia was associated with lower DHA (0.40±0.22 vs. 0.53±0.27; p=0.018), but higher AA (1.14±0.44 vs. 0.93±0.30; p<0.006) and AA:DHA ratio (4.31±4.04 vs. 2.29±2.79; p<0.001). In multivariate analysis, colostrum DHA correlated with plasma DHA (β, 0.417; p=0.002), maternal age (β, -0.290; p=0.028) and preeclampsia (β, -0.270; p=0.042). Preterm colostrum FA profile in Tunisian women is comparable to those of other populations. Colostrum AA and DHA levels are altered in aged and pre-eclamptic women.
authors.affiliation: UR05/08-08, LR99ES11, Department of Biochemistry, Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar, 1007 Jebbari, Tunis, Tunisia.
authors.forename: S
authors.initials: S
authors.lastname: Fares
authors.affiliation: UR05/08-08, LR99ES11, Department of Biochemistry, Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar, 1007 Jebbari, Tunis, Tunisia.
authors.forename: M M
authors.initials: MM
authors.lastname: Sethom
authors.affiliation: UR05/08-08, LR99ES11, Department of Biochemistry, Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar, 1007 Jebbari, Tunis, Tunisia. Electronic address: moncef.feki@rns.tn.
authors.forename: M
authors.initials: M
authors.lastname: Feki
authors.affiliation: Service of Neonatology, Centre of Maternity and Neonatology, Faculty of Medicine of Tunis, University of Tunis El Manar, 1007 Jebbari, Tunis, Tunisia.
authors.forename: M
authors.initials: M
authors.lastname: Cheour
authors.affiliation: UR05/08-08, LR99ES11, Department of Biochemistry, Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar, 1007 Jebbari, Tunis, Tunisia.
authors.forename: H
authors.initials: H
authors.lastname: Sanhaji
authors.affiliation: Service of Neonatology, Centre of Maternity and Neonatology, Faculty of Medicine of Tunis, University of Tunis El Manar, 1007 Jebbari, Tunis, Tunisia.
authors.forename: S
authors.initials: S
authors.lastname: Kacem
authors.affiliation: UR05/08-08, LR99ES11, Department of Biochemistry, Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar, 1007 Jebbari, Tunis, Tunisia.
authors.forename: N
authors.initials: N
authors.lastname: Kaabachi
mesh_terms: D000328:Adult; D016718:Arachidonic Acid / Q000032:analysis / Q000097:blood; D002849:Chromatography, Gas; D003126:Colostrum / Q000737:chemistry*; D004281:Docosahexaenoic Acids / Q000032:analysis / Q000097:blood; D005227:Fatty Acids / Q000032:analysis* / Q000097:blood; D005231:Fatty Acids, Unsaturated / Q000032:analysis / Q000097:blood; D005260:Female; D005865:Gestational Age; D006801:Humans; D007234:Infant, Premature; D019787:Linoleic Acid / Q000032:analysis / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D012307:Risk Factors; D014416:Tunisia; D055815:Young Adult
chemical_list: D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid; D019787:Linoleic Acid
keywords: Arachidonic acid; Breast milk; Colostrum; Docosahexaenoic acid; Preeclampsia