title: Spectral versus time-domain OCT in detecting preoperative epiretinal membranes that accompany macular holes.
abstract: OBJECTIVE
  To compare the sensitivities of spectral-domain optical coherence tomography (SD-OCT) versus time-domain OCT (TD-OCT) in identifying epiretinal membranes (ERM) preoperatively in patients who underwent surgery for full-thickness macular holes (FTMH).
  
  
  METHODS
  This is an interventional retrospective case series of 59 eyes diagnosed with FTMHs who underwent 25-G pars plana vitrectomy with internal limiting membrane peeling between 2009 and 2015. Preoperative OCTs were obtained by SD-OCT (Spectralis, Heidelberg, Germany) or TD-OCT (Stratus, Carl Zeiss Meditec, Dublin, CA, USA). Volume scans were reviewed for ERM accompanying the FTMH. This was compared to indocyanine green-negative staining and intraoperative findings of ERM as the gold standard.
  
  
  RESULTS
  Baseline characteristics between the SD-OCT and TD-OCT groups were comparable. Mean duration of postoperative follow-up was 41.4 weeks (±49.0). Of 59 eyes, 33 (55.9%) exhibited an ERM intraoperatively. Four ERMs (SD-OCT group) compared to 12 (TD-OCT group) were not visualized on preoperative OCT (p = 0.003). Sensitivity and specificity of SD-OCT in ERM detection was 79% and 100% compared to 14% and 91% for TD-OCT. Visual acuity improved in both arms (0.5 and 0.3 logMAR units in SD-OCT and TD-OCT, respectively (p = 0.002, 0.0002).
  
  
  CONCLUSIONS
  We found that SD-OCT was superior to TD-OCT in identifying the presence of ERM preoperatively in patients who underwent macular hole surgery. Since ERMs may decrease the chance of successful pharmacologic vitreolysis, we recommend using SD-OCT over TD-OCT in the evaluation of patients with FTMH to more accurately identify ERMs and allow more comprehensive treatment decisions (pharmacologic versus surgical).
authors.affiliation:  Department of Ophthalmology, Beaumont Eye Institute, Royal Oak, MI - USA.
authors.forename: Prethy
authors.initials: P
authors.lastname: Rao
authors.affiliation:  Department of Ophthalmology, Beaumont Eye Institute, Royal Oak, MI - USA.| Associated Retinal Consultants, Royal Oak, MI - USA.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yonekawa
authors.affiliation:  Department of Ophthalmology, Beaumont Eye Institute, Royal Oak, MI - USA.| Associated Retinal Consultants, Royal Oak, MI - USA.
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Thomas
authors.affiliation:  Department of Ophthalmology, Beaumont Eye Institute, Royal Oak, MI - USA.| Associated Retinal Consultants, Royal Oak, MI - USA.
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Drenser
mesh_terms: D000368:Aged; D004396:Coloring Agents / Q000008:administration & dosage; D019773:Epiretinal Membrane / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D005858:Germany; D006801:Humans; D007208:Indocyanine Green / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D012167:Retinal Perforations / Q000175:diagnosis* / Q000601:surgery; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity / Q000502:physiology; D014821:Vitrectomy
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green