title: The inheritance of centromere identity.
abstract: CENP-A (Centromere protein A) is a histone H3 variant that epigenetically determines the centromere position, but the mechanism of its centromere inheritance is obscure. We propose that CENP-A ubiquitylation, which is inherited through dimerization between rounds of cell division, is a candidate for the epigenetic mark of centromere identity.
authors.affiliation: Center for Childhood Cancer and Blood Diseases, The Research Institute at Nationwide Children's Hospital , Columbus, OH, USA.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Niikura
authors.affiliation: Center for Childhood Cancer and Blood Diseases, The Research Institute at Nationwide Children's Hospital , Columbus, OH, USA.
authors.forename: Risa
authors.initials: R
authors.lastname: Kitagawa
authors.affiliation: Center for Childhood Cancer and Blood Diseases, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA; Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH, USA.
authors.forename: Katsumi
authors.initials: K
authors.lastname: Kitagawa
keywords: CENP-A; CUL4A-RBX1-COPS8 E3 ligase; centromere; centromere identity; dimerization; epigenetics; kinetochore; lysine 124 (K124); monoubiquitin-fused CENP-A mutant; neocentromere; ubiquitylation