title: Antiphage activity of sera during phage therapy in relation to its outcome.
abstract: The aim was to study the association between the phage neutralization of patients' sera and the clinical outcome of phage therapy (PT).
  
  
  
  About 62 patients with various bacterial infections receiving PT as well as 30 healthy volunteers were studied.
  
  
  
  Antiphage activity of sera (AAS) was examined using the phage neutralization test of different types of phages before and during PT in relation to the route of phage administration and correlated with the results of PT.
  
  
  
  The analysis of the association between AAS level and clinical results indicated that the level of AAS is not correlated with the outcome of PT.
authors.affiliation: Laboratory of Bacteriophages, Hirszfeld Institute of Immunology & Experimental Therapy, Polish Academy of Sciences (HIIET PAS), Wrocław, Poland.
authors.forename: Marzanna
authors.initials: M
authors.lastname: Łusiak-Szelachowska
authors.affiliation: Laboratory of Bacteriophages, Hirszfeld Institute of Immunology & Experimental Therapy, Polish Academy of Sciences (HIIET PAS), Wrocław, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Żaczek
authors.affiliation: Laboratory of Bacteriophages, Hirszfeld Institute of Immunology & Experimental Therapy, Polish Academy of Sciences (HIIET PAS), Wrocław, Poland.|Phage Therapy Unit, Hirszfeld Institute of Immunology & Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Weber-Dąbrowska
authors.affiliation: Laboratory of Bacteriophages, Hirszfeld Institute of Immunology & Experimental Therapy, Polish Academy of Sciences (HIIET PAS), Wrocław, Poland.|Phage Therapy Unit, Hirszfeld Institute of Immunology & Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.|Department of Clinical Immunology, Transplantation Institute, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Ryszard
authors.initials: R
authors.lastname: Międzybrodzki
authors.affiliation: Phage Therapy Unit, Hirszfeld Institute of Immunology & Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.|Medical Sciences Institute, Katowice School of Economics, Katowice, Poland.
authors.forename: Sławomir
authors.initials: S
authors.lastname: Letkiewicz
authors.affiliation: Laboratory of Bacteriophages, Hirszfeld Institute of Immunology & Experimental Therapy, Polish Academy of Sciences (HIIET PAS), Wrocław, Poland.|Phage Therapy Unit, Hirszfeld Institute of Immunology & Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Fortuna
authors.affiliation: Phage Therapy Unit, Hirszfeld Institute of Immunology & Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Rogóż
authors.affiliation: Phage Therapy Unit, Hirszfeld Institute of Immunology & Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Szufnarowski
authors.affiliation: Laboratory of Bacteriophages, Hirszfeld Institute of Immunology & Experimental Therapy, Polish Academy of Sciences (HIIET PAS), Wrocław, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Jończyk-Matysiak
authors.affiliation: IBSS BIOMED S.A., Cracow, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Olchawa
authors.affiliation: Faculty of Chemistry, Wrocław University of Technology, Wrocław, Poland.
authors.forename: Kinga M
authors.initials: KM
authors.lastname: Walaszek
authors.affiliation: Laboratory of Bacteriophages, Hirszfeld Institute of Immunology & Experimental Therapy, Polish Academy of Sciences (HIIET PAS), Wrocław, Poland.|Phage Therapy Unit, Hirszfeld Institute of Immunology & Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.|Department of Clinical Immunology, Transplantation Institute, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Górski
mesh_terms: D000914:Antibodies, Viral / Q000097:blood*; D001424:Bacterial Infections / Q000097:blood* / Q000628:therapy*; D006090:Gram-Negative Bacteria / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000302:isolation & purification; D006801:Humans; D009500:Neutralization Tests / Q000379:methods*; D000071059:Phage Therapy / Q000379:methods*
chemical_list: D000914:Antibodies, Viral
keywords: antibiotic resistance; bacterial infections; bacteriophages; clinical results; human sera; phage neutralization; phage therapy