title: Correlation of Lipid Profile and Risk of Developing Type 2 Diabetes Mellitus in 10-14 Year Old Children.
abstract: OBJECTIVE
  The role of lipid profile in predicting the risk of Type 2 diabetes mellitus (T2DM) in children is not clearly established. Our aim is to screen non-diabetic children aged 10-14 years for risk of developing T2DM and evaluate the association of abnormal lipids and socioeconomic status (SES).
  
  
  METHODS
  Data on race/ethnicity, family history, body mass index percentile, blood pressure and presence of neck pigmentation (acanthosis nigricans) were collected from 149 non-diabetic children. Using these factors, children were classified into low risk (<3 risk factors) and high risk (>3 risk factors) groups. Logistic regression model and chi-square tests were used to evaluate the association of blood lipid profile and demographic variables. Independent t-test was used to compare the ratio of Total Cholesterol (TC) and High Density Lipids (HDL) with T2DM risk.
  
  
  RESULTS
  60% of children were at high risk for developing T2DM. HDL (p<0.001), triglycerides (p=0.02) and TC/HDL ratio (p<.001) were significantly abnormal in high risk group. Low SES showed a marginal association with high risk group. There were no gender or age differences between high and low risk groups.
  
  
  CONCLUSIONS
  The significant determinants associated with high risk group were modifiable factors providing an opportunity for early intervention and prevention.
authors.affiliation: Department of Pediatrics, University of North Texas Health Science Center, Fort Worth, TX, USA.
authors.forename: Nusrath M
authors.initials: NM
authors.lastname: Habiba
authors.forename: Kimberly G
authors.initials: KG
authors.lastname: Fulda
authors.forename: Riyaz
authors.initials: R
authors.lastname: Basha
authors.forename: Deep
authors.initials: D
authors.lastname: Shah
authors.forename: Shane
authors.initials: S
authors.lastname: Fernando
authors.forename: Bao
authors.initials: B
authors.lastname: Nguyen
authors.forename: Yi
authors.initials: Y
authors.lastname: Xiong
authors.forename: Susan F
authors.initials: SF
authors.lastname: Franks
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Matches
authors.forename: Richard D
authors.initials: RD
authors.lastname: Magie
authors.forename: W Paul
authors.initials: WP
authors.lastname: Bowman
mesh_terms: D000052:Acanthosis Nigricans / Q000175:diagnosis / Q000208:ethnology / Q000503:physiopathology; D000293:Adolescent; D044383:Black People; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000208:ethnology; D005260:Female; D064368:Healthy Volunteers; D006630:Hispanic or Latino; D006801:Humans; D016015:Logistic Models; D008297:Male; D011379:Prognosis; D012307:Risk Factors; D012923:Social Class; D013781:Texas; D014280:Triglycerides / Q000097:blood*; D044465:White People; D001741:Black or African American
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides