title: Nonconventional Use of Flash-Lamp Pulsed-Dye Laser in Dermatology.
abstract: Flash-lamp pulsed-dye laser (FPDL) is a nonablative technology, typically used in vascular malformation therapy due to its specificity for hemoglobin. FPDL treatments were performed in a large group of patients with persistent and/or recalcitrant different dermatological lesions with cutaneous microvessel involvement. In particular, 149 patients (73 males and 76 females) were treated. They were affected by the following dermatological disorders: angiokeratoma circumscriptum, genital and extragenital viral warts, striae rubrae, basal cell carcinoma, Kaposi's sarcoma, angiolymphoid hyperplasia, and Jessner-Kanof disease. They all underwent various laser sessions. 89 patients (59.7%) achieved excellent clearance, 32 patients (21.4%) achieved good-moderate clearance, 19 patients (12.7%) obtained slight clearance, and 9 subjects (6.1%) had low or no removal of their lesion. In all cases, FPDL was found to be a safe and effective treatment for the abovementioned dermatological lesions in which skin microvessels play a role in pathogenesis or development. Further and single-indication studies, however, are required to assess a standardized and reproducible method for applying this technology to "off-label" indications.
authors.affiliation: Department of Dermatology, University of Rome "Tor Vergata", Viale Oxford 81, 00133 Rome, Italy.
authors.forename: Steven
authors.identifier: 0000-0002-3828-0883
authors.initials: S
authors.lastname: Nisticò
authors.affiliation: Department of Dermatology, University of Florence, Florence, Italy.
authors.forename: Piero
authors.identifier: 0000-0002-5323-0737
authors.initials: P
authors.lastname: Campolmi
authors.affiliation: Department of Dermatology, University of Florence, Florence, Italy.
authors.forename: Silvia
authors.identifier: 0000-0002-0681-7690
authors.initials: S
authors.lastname: Moretti
authors.affiliation: Laser in Dermatology Unit, University of Rome "Tor Vergata", Rome, Italy.
authors.forename: Ester
authors.initials: E
authors.lastname: Del Duca
authors.affiliation: Department of Dermatology, University of Florence, Florence, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Bruscino
authors.affiliation: Department of Dermatology, University of Florence, Florence, Italy.
authors.forename: Rossana
authors.initials: R
authors.lastname: Conti
authors.affiliation: Department of Dermatology, University of Florence, Florence, Italy.
authors.forename: Andrea
authors.identifier: 0000-0002-9157-5189
authors.initials: A
authors.lastname: Bassi
authors.affiliation: Laser in Dermatology Unit, University of Rome "Tor Vergata", Rome, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cannarozzo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D054025:Lasers, Dye / Q000627:therapeutic use*; D008029:Lighting / Q000379:methods*; D028022:Low-Level Light Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D017445:Skin Diseases, Vascular / Q000473:pathology* / Q000532:radiotherapy*; D016896:Treatment Outcome; D055815:Young Adult