title: IGFBP6 Regulates Cell Apoptosis and Migration in Glioma.
abstract: The insulin-like growth factor binding protein 6 (IGFBP6), as an inhibitor of IGF-II actions, plays an important role in inhibiting survival and migration of tumor cells. In our study, we intended to demonstrate the biological function of IGFBP6 in the development of glioma and its clinical significance. Firstly, Western blot and immunohistochemistry revealed that the expression of IGFBP6 inversely correlated with glioma grade. Secondly, multivariate analysis with the Cox proportional hazards model and Kaplan-Meier analysis indicated that IGFBP6 could be an independent prognostic factor for the survival of glioma patients. In addition, overexpression of IGFBP6 induced glioma cell apoptosis, and depletion of IGFBP6 had the opposite action. Finally, overexpression of IGFBP6 inhibited migration of glioma cells, and depletion of IGFBP6 had the opposite action. Together our findings suggest that IGFBP6 might be an important regulator and prognostic factor for glioma.
authors.affiliation: Department of Radiation Oncology and Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, 226001, Jiangsu, People's Republic of China.|Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong, 226001, People's Republic of China.|Department of Intensive Care Unit, Affiliated Cancer Hospital of Nantong University, Nantong, 226361, People's Republic of China.
authors.forename: Yuanqi
authors.initials: Y
authors.lastname: Bei
authors.affiliation: Department of Neurosurgery, The Affiliated Hospital of Nantong University, Xisi Road No. 20, Nantong, 226001, People's Republic of China.
authors.forename: Qingfeng
authors.initials: Q
authors.lastname: Huang
authors.affiliation: Department of Neurosurgery, The Affiliated Hospital of Nantong University, Xisi Road No. 20, Nantong, 226001, People's Republic of China.
authors.forename: Jianhong
authors.initials: J
authors.lastname: Shen
authors.affiliation: Department of Neurosurgery, The Affiliated Hospital of Nantong University, Xisi Road No. 20, Nantong, 226001, People's Republic of China.
authors.forename: Jinlong
authors.initials: J
authors.lastname: Shi
authors.affiliation: Department of Radiation Oncology and Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, 226001, Jiangsu, People's Republic of China.|Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong, 226001, People's Republic of China.
authors.forename: Chaoyan
authors.initials: C
authors.lastname: Shen
authors.affiliation: Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong, 226001, People's Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Xu
authors.affiliation: Department of Neurosurgery, Affiliated Wuxi Second Hospital of Nanjing Medical University, Wuxi, 214002, People's Republic of China.
authors.forename: Hao
authors.initials: H
authors.lastname: Chang
authors.affiliation: Department of Radiation Oncology and Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, 226001, Jiangsu, People's Republic of China.|Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong, 226001, People's Republic of China.
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Xia
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Suzhou University, Suzhou, 215000, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Radiation Oncology and Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, 226001, Jiangsu, People's Republic of China.
authors.forename: Bin
authors.initials: B
authors.lastname: Ji
authors.affiliation: Department of Neurosurgery, The Affiliated Hospital of Nantong University, Xisi Road No. 20, Nantong, 226001, People's Republic of China. chenjianguont@sina.com.
authors.forename: JianGuo
authors.initials: J
authors.lastname: Chen
mesh_terms: D017209:Apoptosis; D001932:Brain Neoplasms / Q000378:metabolism* / Q000473:pathology*; D045744:Cell Line, Tumor; D002465:Cell Movement; D005260:Female; D055785:Gene Knockdown Techniques; D005910:Glioma / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D018976:Insulin-Like Growth Factor Binding Protein 6 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D016019:Survival Analysis
chemical_list: D018976:Insulin-Like Growth Factor Binding Protein 6
keywords: Apoptosis; Glioma; IGFBP6; Migration; Prognosis