title: Different Risk Indictors of Diabetic Nephropathy in Transforming Growth Factor-beta1 T869C CC/CT Genotype and TT Genotype.
abstract: BACKGROUND
  Transforming growth factor-beta 1(TGF-β1) T869C (rs1800470, the same below) gene polymorphism is notably relative with the development of Diabetic Nephropathy (DN), and CC/CT genotype diabetic have higher frequency of than TT genotype diabetic. To find out individual risk factors in the two genotypes especially in susceptible genotype could provide more efficient and targeted prevention.
  
  
  METHODS
  This was a prospective cohort study. A total of 251 type 2 diabetes mellitus (T2DM) patients [53.4% male, 56(52-67) years] were enrolled in this cohort study. Multiple concerned factors were collected and the relationship of these risk factors and development of DN were evaluated by Cox regression analysis. Hazard ratios of development of DN were calculated by Kaplan-Meier curves and the Cox proportional hazards model for CC/CT genotype versus TT genotype patients.
  
  
  RESULTS
  TGF-β1 T869C gene polymorphism was an independent predictor of DN in T2DM patients (HR, 2.08; 95%CI, 1.18-3.66; P=0.012). Hyperlipemia (HR, 1.91; 95%CI, 1.19-3.08; P=0.007), age (HR, 0.95; 95%CI, 0.93-0.98; P=0.001) and smoking status (HR, 2.36; 95%CI, 1.07-5.21; P=0.033) were risk indictors of the development of DN in CC/CT genotype patients. HbA1c (HR, 2.8; 95%CI, 1.07-7.30; P=0.036), hypertension (HR, 7.46; 95%CI, 1.38-40.29; P=0.02), and hyperlipemia (HR, 12.33; 95%CI, 1.05-145.39; P=0.046) were risk indictors for the development of DN in TT genotype patients.
  
  
  CONCLUSIONS
  TGF-β1 T869C gene polymorphism was an independent predictor of DN for T2DM patients and CC/CT genotype had higher susceptibility to DN. CC/CT genotype and TT genotype patients had different risk indictors of DN.
authors.affiliation: Dept. of Endocrinology of Hangzhou Red Cross Hospital, Hangzhou, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Mou
authors.affiliation: Dept. of Endocrinology of Hangzhou Red Cross Hospital, Hangzhou, China.
authors.forename: Yinghui
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Dept. of Endocrinology of Hangzhou Red Cross Hospital, Hangzhou, China.
authors.forename: Diyi
authors.initials: D
authors.lastname: Zhou
authors.affiliation: Dept. of Endocrinology of Hangzhou Red Cross Hospital, Hangzhou, China.
authors.forename: Yongbin
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Dept. of Endocrinology of Hangzhou Red Cross Hospital, Hangzhou, China.
authors.forename: Guoling
authors.initials: G
authors.lastname: Ma
authors.affiliation: Dept. of Endocrinology of Hangzhou Red Cross Hospital, Hangzhou, China.
authors.forename: Chengmin
authors.initials: C
authors.lastname: Shou
authors.affiliation: Dept. of Endocrinology of Hangzhou Red Cross Hospital, Hangzhou, China.
authors.forename: Jiawei
authors.initials: J
authors.lastname: Chen
authors.affiliation: Dept. of Endocrinology of Hangzhou Red Cross Hospital, Hangzhou, China.
authors.forename: Danyang
authors.initials: D
authors.lastname: Zhou
keywords: Diabetic nephropathy; Risk; T869C; TGF-β1; Type 2 diabetes mellitus