title: To assess differential features of marrow adiposity between postmenopausal women with osteoarthritis and osteoporosis using water/fat MRI.
abstract: To assess the differential features of marrow adiposity between osteoarthritis (OA) and osteoporosis (OP) in postmenopausal women using water/fat MRI.
  
  
  
  This cross-sectional study included 97 postmenopausal women (OA [n = 25], OA + osteopenia [n = 27], OA + OP [n = 23], and OP groups [n = 22]). Water/fat MRI, dual-energy x-ray absorptiometry and biochemical analysis were performed to assess vertebral marrow fat fraction, bone mineral density, and bone biomarkers, respectively. Harris Hip Score was recorded to evaluate hip function.
  
  
  
  There were significant differences in marrow fat content among the OA, OA + osteopenia, and OA + OP groups, between OP and OA participants with normal bone mass or osteopenia (all P < 0.05); no significant difference was observed between OA + OP and OP groups. Serum levels of leptin and β-Crosslaps in OA with normal bone mass and osteopenic OA groups were higher than in OP group. Marrow fat fraction was inversely correlated with Harris Hip Score (r = -0.371, P = 0.013), bone mineral density (r = -0.554, P = 0.009) and leptin levels (r = -0.610, P < 0.001). In multivariate regression analysis, marrow fat fraction was found to have a consistent and unchanged inverse association with leptin levels (Sβ = -0.311, P = 0.002) and bone mineral density (Sβ =  -0.265, P = 0.006) after adjusting for age, years since menopause, and body mass index.
  
  
  
  Postmenopausal OA with OP have a phenotype with higher marrow adiposity. OA and OP could coexist, for the presence of a specific subgroup of OA with increased marrow fat accumulation and high risk of developing OP.
authors.affiliation: 1Department of Radiology, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China 2Xinzhuang Community Health Center, Shanghai, China 3East Hospital, Tongji University School of Medicine, Shanghai, China 4Department of Spinal Disease Unit, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China 5First Affiliated Hospital of Dalian Medical University, Dalian, China 6Affiliated Hospital of North Sichuan Medical College, Sichuan, China 7Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China 8Department of Radiology, Wayne State University, Detroit, MI.
authors.forename: Guanwu
authors.initials: G
authors.lastname: Li
authors.forename: Zheng
authors.initials: Z
authors.lastname: Xu
authors.forename: Jingzheng
authors.initials: J
authors.lastname: Fan
authors.forename: Wei
authors.initials: W
authors.lastname: Yuan
authors.forename: Lina
authors.initials: L
authors.lastname: Zhang
authors.forename: Lingmi
authors.initials: L
authors.lastname: Hou
authors.forename: Dongmei
authors.initials: D
authors.lastname: Wu
authors.forename: Shixin
authors.initials: S
authors.lastname: Chang
authors.forename: Horea
authors.initials: H
authors.lastname: Calimente
authors.forename: Jiani
authors.initials: J
authors.lastname: Hu
mesh_terms: D015502:Absorptiometry, Photon; D050154:Adiposity; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D015519:Bone Density; D001853:Bone Marrow / Q000000981:diagnostic imaging / Q000473:pathology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D010003:Osteoarthritis / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D015663:Osteoporosis, Postmenopausal / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D017698:Postmenopause
chemical_list: D015415:Biomarkers; D020738:Leptin