title: Novel approaches in preclinical HIV vaccine research.
abstract: The purpose is to review recent novel approaches in HIV vaccine research and development being undertaken in the preclinical and early clinical space, as well as related and novel nonvaccine approaches such as genetic delivery of broadly neutralizing antibodies for protection from HIV infection and AIDS.
  
  
  
  We review novel HIV envelope immunogen design, including native trimer and germline targeting approaches as well as genetic delivery of broadly neutralizing antibodies and replicating vector vaccinesSUMMARY: Despite 30+ years of research and development, and billions of dollars spent, a well tolerated and effective HIV vaccine remains a public health priority for any chance of ending the AIDS pandemic. It has become very clear that significant investments in novel technologies, innovation, and multidisciplinary science will be necessary to accelerate progress.
authors.affiliation: aInternational AIDS Vaccine InitiativebThe Human Vaccines Project, New York City, New York, USA.
authors.forename: Jeffrey T
authors.initials: JT
authors.lastname: Safrit
authors.forename: Wayne C
authors.initials: WC
authors.lastname: Koff
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology* / Q000302:isolation & purification*; D035843:Biomedical Research / Q000639:trends; D055808:Drug Discovery / Q000639:trends; D004353:Drug Evaluation, Preclinical; D015658:HIV Infections / Q000517:prevention & control* / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*
chemical_list: D016915:AIDS Vaccines