title: Radioiodination and biological evaluation of candesartan as a tracer for cardiovascular disorder detection.
abstract: The goal of the study aims to evaluate newly radioiodinated candesartan (CAN) as a potential cardiovascular tracer. CAN was labeled using125I with chloramine-T (Ch-T) and N-bromosuccinimide (NBS) with full characterization of cold Iodo-candesartan. Factors such as pH, reaction temperature, reaction time, substrate, and oxidizing agent amounts were studied to optimize the radioiodination of CAN. The optimum radiochemical yield of125I-CAN was 98%. The labeled compound was separated and purified using high-pressure liquid chromatography. The biological distribution indicates the suitability of125I-CAN as a novel tracer to detect cardiovascular disorders.
authors.affiliation: Labeled Compounds Department, Radioisotopes Production and Radioactive Sources Division, Hot Laboratories Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt. msanad74@yahoo.com.
authors.forename: M H
authors.initials: MH
authors.lastname: Sanad
authors.affiliation: Labeled Compounds Department, Radioisotopes Production and Radioactive Sources Division, Hot Laboratories Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt.
authors.forename: Kh M
authors.initials: KM
authors.lastname: Sallam
authors.affiliation: Labeled Compounds Department, Radioisotopes Production and Radioactive Sources Division, Hot Laboratories Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt.
authors.forename: F A
authors.initials: FA
authors.lastname: Marzook
authors.affiliation: Labeled Compounds Department, Radioisotopes Production and Radioactive Sources Division, Hot Laboratories Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt.
authors.forename: S M
authors.initials: SM
authors.lastname: Abd-Elhaliem
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000737:chemistry* / Q000493:pharmacokinetics; D001713:Biphenyl Compounds; D002318:Cardiovascular Diseases / Q000175:diagnosis*; D002700:Chloramines / Q000737:chemistry; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D007457:Iodine Radioisotopes / Q000737:chemistry*; D007700:Kinetics; D051379:Mice; D016877:Oxidants / Q000737:chemistry; D010084:Oxidation-Reduction; D011849:Radioactive Tracers; D011854:Radiochemistry; D013777:Tetrazoles / Q000737:chemistry* / Q000493:pharmacokinetics; D014018:Tissue Distribution; D014105:Tosyl Compounds / Q000737:chemistry
chemical_list: D001562:Benzimidazoles; D001713:Biphenyl Compounds; D002700:Chloramines; D007457:Iodine Radioisotopes; D016877:Oxidants; D011849:Radioactive Tracers; D013777:Tetrazoles; D014105:Tosyl Compounds; C016300:chloramine-T; C081643:candesartan
keywords: biological distribution; candesartan; cardiovascular; radioiodination