title: The Relevance of Group II Glutamate Receptors Expression to Anxiety.
abstract: The interface of receptor-mediated regulation of cellular signaling and neurological outputs remains an active field of investigation. The metabotropic G protein-coupled glutamate receptors, and in particular, the group II cyclic adenosine mono-phosphate (cAMP)-lowering metabotropic glutamate receptors 2 and 3 (mGlu2/3 glutamate receptors), have gained interest as therapeutic targets in different forms of neurological disorders. This review explores mGlu2/3 glutamate receptors expression, pharmacological activation, and signaling links to anxiety, as assessed in animal models and in clinical trials.
authors.affiliation: Departments of Chemistry and Psychology, Binghamton University, New York, NY.
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Ravid
authors.affiliation: Department of Psychological and Brain Sciences, Boston University, Boston, MA.
authors.forename: David I
authors.initials: DI
authors.lastname: Mostofsky
mesh_terms: D000818:Animals; D001007:Anxiety / Q000235:genetics / Q000378:metabolism*; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D006801:Humans; D018094:Receptors, Metabotropic Glutamate / Q000235:genetics*; D015398:Signal Transduction
chemical_list: D018094:Receptors, Metabotropic Glutamate