title: CORRELATION OF HELICOBACTER PYLORI INFECTION WITH DEVELOPMENT OF CARDIOVASCULAR RISK IN PATIENTS WITH CORONARY HEART DISEASE IN ASSOCIATION WITH TYPE 2 DIABETES MELLITUS.
abstract: Recent years have demonstrated the possible existence of association between infection Helicobacter pylori (HP), coronary heart disease (CHD) and type 2 diabetes mellitus (DM-2). The refinement of traditional and non-traditional factors of cardiovascular risk in patients with CHD in association with DM-2 of HP-seropositiveis currently important. In this regard, we have studied the influence of HP infection on cardiovascular risk in patients with CHD and DM-2. 60 persons with CHD in association with DM-2with/without HP have been examined. The results of own studies have shown that HP-seropositive patients with CHD in association with DM-2have pro-atherogenic lipid pattern, significantly higher rates of glucose in fasting state, level of C-reactive protein against the background of hyperinsulinemia, hypoadiponectinemia compared with HP-seronegative patients. HP infection association with increasing cardiovascular risk, depending on the genotype of the polymorphic marker rs1044471 of ADIPOR2 gene have not been found. At the same time, HP-seropositive patients with TT genotype of the polymorphic gene ADIPOR2 rs1044471constitutethe risk group of cardiovascular events formation by main metabolic indicators. The received data suggest that HP infection is important in development of cardiovascular risk in patients with CHD in association withDM-2, the presence of which aggravates cardio metabolic status of the patient.
authors.affiliation: SI "The National Institute of Therapy named after L.T. Malaya of National Academy of Medical Sciences of Ukraine», Kharkiv, Ukraine.
authors.forename: T
authors.initials: T
authors.lastname: Kozyrieva
authors.affiliation: SI "The National Institute of Therapy named after L.T. Malaya of National Academy of Medical Sciences of Ukraine», Kharkiv, Ukraine.
authors.forename: E
authors.initials: E
authors.lastname: Kolesnikova
authors.affiliation: SI "The National Institute of Therapy named after L.T. Malaya of National Academy of Medical Sciences of Ukraine», Kharkiv, Ukraine.
authors.forename: I
authors.initials: I
authors.lastname: Shut
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology* / Q000382:microbiology; D003327:Coronary Disease / Q000097:blood / Q000150:complications; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications*; D005260:Female; D005838:Genotype; D016481:Helicobacter Infections / Q000097:blood / Q000150:complications* / Q000382:microbiology; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D054419:Receptors, Adiponectin / Q000235:genetics; D018570:Risk Assessment
chemical_list: C475420:ADIPOR2 protein, human; D000907:Antibodies, Bacterial; D008055:Lipids; D054419:Receptors, Adiponectin