title: [Acute kidney injury : A clinical syndrome].
abstract: Acute kidney injury (AKI) is a clinical syndrome occurring in the context of multiple and diverse disease entities. Although the term AKI implies renal damage as well as functional impairment or a combination of both, diagnosis is solely based on the functional parameters serum creatinine and urine output. Independent of the underlying disease and even assuming full recovery of renal function, AKI is associated with increased morbidity and mortality not only during the acute situation, but also long term. Awareness of the individual risk profile of each patient and the variety of causes and clinical manifestations of AKI is pivotal for prophylaxis, diagnosis, and therapy. The complexity of the clinical syndrome in the context of sepsis, solid organ transplantation, malignancy, and autoimmune diseases requires differentiated diagnostic and therapeutic approaches and interdisciplinary care.
authors.affiliation: Klinik für Nephrologie, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Deutschland. anja.bienholz@uk-essen.de.
authors.forename: A
authors.initials: A
authors.lastname: Bienholz
authors.affiliation: Klinik für Nephrologie, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Deutschland.
authors.forename: A
authors.initials: A
authors.lastname: Kribben
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000628:therapy*; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000628:therapy*; D019317:Evidence-Based Medicine; D005858:Germany; D006801:Humans; D007677:Kidney Function Tests / Q000379:methods*; D016030:Kidney Transplantation / Q000379:methods*; D013577:Syndrome; D016896:Treatment Outcome
keywords: Autoimmune diseases; Biomarkers; Chemotherapy; Kidney transplantation; Neoplasms; Sepsis