title: Pregnancy outcome after false diagnosis of fetal growth restriction.
abstract: OBJECTIVE
  To evaluate pregnancy outcome following false diagnosis of fetal growth restriction (FGR).
  
  
  METHODS
  Retrospective analysis of all singleton term deliveries of appropriately grown fetuses (10-90th weight percentiles) in a single medical center (2007-2014). Elective cesarean-section, diabetes, and hypertension were excluded. Cohort was stratified based on third trimester sonographic estimated-fetal-weight (≥32 weeks). Women with false diagnosis FGR (<10th percentile) were compared with the rest (control). Induction of labor, cesarean deliveries, and short-term perinatal outcome were compared. Logistic regression analysis was performed to adjust outcome for birth weight and gestational age at delivery.
  
  
  RESULTS
  Of 34,474 pregnancies, 415 were falsely diagnosed as FGR (1.2%). Women in study group delivered earlier (38.6 ± 1.1 versus. 39.0 ± 0.9) with lower birth weights (2856 ± 270 versus 3271 ± 307 grams) and increased rate of labor inductions (19.8% versus 6.4%) and cesarean deliveries (10.8% versus 5.7%). Despite appropriate birth weight, study group neonates had higher rates of NICU admissions (10.6% versus 6.8%), mechanical ventilation (1.7% versus 0.5%), transient tachypnea of the newborn (1.7% versus 0.5%), hypoglycemia (1.7% versus 0.5%), and jaundice (11.3% versus 7.0%). p < 0.01 for all. All remained significant after adjustment to confounders.
  
  
  CONCLUSIONS
  False diagnosis of FGR is associated with higher rates of induction of labor, cesarean deliveries, and short-term adverse neonatal outcome.
authors.affiliation: a Helen Schneider Hospital for Women, Sackler Faculty of Medicine, Rabin Medical Center, Tel Aviv University , Tel Aviv , Israel and.
authors.forename: Rinat
authors.initials: R
authors.lastname: Gabbay-Benziv
authors.affiliation: b Lis Maternity Hospital, Sackler Faculty of Medicine, The Tel-Aviv Sourasky Medical Center, Tel Aviv University , Tel Aviv , Israel.
authors.forename: Amir
authors.initials: A
authors.lastname: Aviram
authors.affiliation: a Helen Schneider Hospital for Women, Sackler Faculty of Medicine, Rabin Medical Center, Tel Aviv University , Tel Aviv , Israel and.
authors.forename: Eran
authors.initials: E
authors.lastname: Hadar
authors.affiliation: a Helen Schneider Hospital for Women, Sackler Faculty of Medicine, Rabin Medical Center, Tel Aviv University , Tel Aviv , Israel and.
authors.forename: Rony
authors.initials: R
authors.lastname: Chen
authors.affiliation: a Helen Schneider Hospital for Women, Sackler Faculty of Medicine, Rabin Medical Center, Tel Aviv University , Tel Aviv , Israel and.
authors.forename: Ron
authors.initials: R
authors.lastname: Bardin
authors.affiliation: a Helen Schneider Hospital for Women, Sackler Faculty of Medicine, Rabin Medical Center, Tel Aviv University , Tel Aviv , Israel and.
authors.forename: Arnon
authors.initials: A
authors.lastname: Wiznitzer
authors.affiliation: b Lis Maternity Hospital, Sackler Faculty of Medicine, The Tel-Aviv Sourasky Medical Center, Tel Aviv University , Tel Aviv , Israel.
authors.forename: Yariv
authors.initials: Y
authors.lastname: Yogev
mesh_terms: D000293:Adolescent; D000328:Adult; D003951:Diagnostic Errors / Q000009:adverse effects*; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis*; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D055815:Young Adult
keywords: FGR outcome; Fetal growth restriction; estimated fetal weight; false diagnosis