title: The role of dendritic cells in cancer.
abstract: Though present in low numbers, dendritic cells (DCs) are recognized as major players in the control of cancer by adaptive immunity. The roles of cytotoxic CD8+T-cells and Th1 helper CD4+T-cells are well-documented in murine models of cancer and associated with a profound prognostic impact when infiltrating human tumors, but less information is known about how these T-cells gain access to the tumor or how they are primed to become tumor-specific. Here, we highlight recent findings that demonstrate a vital role of CD103+DCs, which have been shown to be experts in cross-priming and the induction of anti-tumor immunity. We also focus on two different mediators that impair the function of tumor-associated DCs: prostaglandin E2and β-catenin. Both of these mediators seem to be important for the exclusion of T-cells in the tumor microenvironment and may represent key pathways to target in optimized treatment regimens against cancer.
authors.affiliation: Center for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital, Herlev, Denmark. 80mhan@gmail.com.|Symphogen A/S, Ballerup, Denmark. 80mhan@gmail.com.
authors.forename: Morten
authors.identifier: http://orcid.org/0000-0002-3738-3100
authors.initials: M
authors.lastname: Hansen
authors.affiliation: Center for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital, Herlev, Denmark.|ISIM, Department of Immunology and Microbiology, Copenhagen University, Copenhagen, Denmark.
authors.forename: Mads Hald
authors.initials: MH
authors.lastname: Andersen
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D015415:Biomarkers; D051546:Cyclooxygenase 2 / Q000378:metabolism; D003713:Dendritic Cells / Q000145:classification / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D015232:Dinoprostone / Q000378:metabolism; D018450:Disease Progression; D006801:Humans; D007113:Immunity, Innate; D039001:Integrin alpha Chains / Q000378:metabolism; D022423:Myeloid Cells / Q000276:immunology / Q000378:metabolism; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D010641:Phenotype; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D019139:Tumor Escape / Q000276:immunology; D059016:Tumor Microenvironment / Q000276:immunology; D051176:beta Catenin / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D015415:Biomarkers; D039001:Integrin alpha Chains; C091367:alpha E integrins; D051176:beta Catenin; D051546:Cyclooxygenase 2; D015232:Dinoprostone
keywords: CD103; Cancer; Dendritic cells; Immunology; PGE2; β-catenin