title: Comparing diagnostic yield of a novel pan-enteric video capsule endoscope with ileocolonoscopy in patients with active Crohn's disease: a feasibility study.
abstract: OBJECTIVE
  Crohn's disease (CD) is typically diagnosed with ileocolonoscopy (IC); however, when inflammation is localized solely in the small bowel, visualization of the entire small-bowel mucosa can be challenging. The aim of this study was to compare the diagnostic yield of a pan-enteric video capsule endoscope (small-bowel colon [SBC] capsule) versus IC in patients with active CD.
  
  
  METHODS
  This was a prospective, multicenter study. Patients with known active CD and proven bowel luminal patency underwent a standardized colon cleansing protocol followed by ingestion of the capsule. After passage of the capsule, IC was performed and recorded. Lesions indicative of active CD were assessed.
  
  
  RESULTS
  One hundred fourteen subjects were screened; 66 subjects completed both endoscopic procedures. The per-subject diagnostic yield rate for active CD lesions was 83.3% for SBC and 69.7% for IC (yield difference, 13.6%; 95% confidence interval [CI], 2.6%-24.7%); 65% of subjects had active CD lesions identified by both modalities. Of the 12 subjects who were positive for active CD by SBC only, 5 subjects were found to have active CD lesions in the terminal ileum. Three subjects were positive for active CD by IC only. Three hundred fifty-five classifying bowel segments were analyzed; the per-segment diagnostic yield rate was 40.6% for SBC and 32.7% for IC (yield difference 7.9%; 95% CI, 3.3%-12.4%).
  
  
  CONCLUSIONS
  This preliminary study shows that the diagnostic yields for SBC might be higher than IC; however, the magnitude of difference between the two is difficult to estimate. Further study is needed to confirm these findings.
authors.affiliation: Mayo Clinic Arizona, Scottsdale, Arizona, USA.
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Leighton
authors.affiliation: Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: Debra J
authors.initials: DJ
authors.lastname: Helper
authors.affiliation: Institute of Gastroenterology and Liver Diseases, Ha'Emek Medical Center, Afula, Israel.
authors.forename: Ian M
authors.initials: IM
authors.lastname: Gralnek
authors.affiliation: IBD Center, Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, and the Sackler Faculty of Medicine, Tel Aviv, Israel.
authors.forename: Iris
authors.initials: I
authors.lastname: Dotan
authors.affiliation: Hospital de Navarra, Navarra, Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Fernandez-Urien
authors.affiliation: Department of Gastroenterology, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Adi
authors.initials: A
authors.lastname: Lahat
authors.affiliation: Gastrointestinal and Liver Specialists of Tidewater, Suffolk, Virginia, USA.
authors.forename: Pramod
authors.initials: P
authors.lastname: Malik
authors.affiliation: The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Gerard E
authors.initials: GE
authors.lastname: Mullin
authors.affiliation: Gastroenterology Department, Centro Hospitalar do Alto Ave, Guimarães, Portugal.
authors.forename: Bruno
authors.initials: B
authors.lastname: Rosa
mesh_terms: D000328:Adult; D053704:Capsule Endoscopy / Q000009:adverse effects; D003092:Colitis / Q000000981:diagnostic imaging*; D003113:Colonoscopy / Q000379:methods; D003424:Crohn Disease / Q000000981:diagnostic imaging*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007079:Ileitis / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D055815:Young Adult