title: Luteoma of Pregnancy Presenting with Severe Maternal Virilisation: A Case Report.
abstract: Luteoma of pregnancy is a rare, benign condition characterized by a tumor-like mass of the ovary that emerges during pregnancy and regresses spontaneously after delivery. It is usually asymptomatic and the diagnosis is generally incidental. Luteoma arises from the proliferation of luteinised cell under the influence of β-hCG and can be hormonally active, with production of androgens resulting in maternal and fetal hirsutism and virilisation. We report a case of a 25-year-old primigravida who presented at 28 weeks of gestation with virilisation symptoms. Serum androgen levels were seven-hundred-fold higher than normal. A diagnosis of pregnancy luteoma was made at the time of caesarean section. The ovarian mass, serum androgen levels, and the condition of the patient improved after delivery.
authors.affiliation: Obstetrics and Gynecology Department, Ospedale Vittorio Emanuele-Policlinico-S. Bambino, 95123 Catania, Italy.
authors.forename: Vincenzo
authors.identifier: 0000-0001-6231-7992
authors.initials: V
authors.lastname: Rapisarda
authors.affiliation: Obstetrics and Gynecology Department, Ospedale Vittorio Emanuele-Policlinico-S. Bambino, 95123 Catania, Italy.
authors.forename: Francesco
authors.identifier: 0000-0002-8760-5349
authors.initials: F
authors.lastname: Pedalino
authors.affiliation: Obstetrics and Gynecology Department, Ospedale Vittorio Emanuele-Policlinico-S. Bambino, 95123 Catania, Italy.
authors.forename: Veronica Concetta
authors.identifier: 0000-0001-7190-3678
authors.initials: VC
authors.lastname: Santonocito
authors.affiliation: Obstetrics and Gynecology Department, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy.
authors.forename: Giorgia
authors.identifier: 0000-0002-5314-0248
authors.initials: G
authors.lastname: Cavalli
authors.affiliation: Obstetrics and Gynecology Department, Ospedale Vittorio Emanuele-Policlinico-S. Bambino, 95123 Catania, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Zarbo