title: Intensity-modulated radiotherapy for relapsed malignant pleural mesothelioma.
abstract: The use of novel radiotherapy techniques is widely increasing, allowing clinicians to treat diseases that were previously difficult to treat with radiation therapy. Malignant pleural mesothelioma is a clear example of this clinical challenge. We describe our first experience with intensity-modulated radiotherapy technique which was used to treat a 73-year-old patient with multiple relapsing malignant pleural mesothelioma. Intensity-modulated radiation therapy has allowed to respect the QUANTEC (quantitative analyses of normal tissue effects in the clinic) dose constraints, patient has experienced a 14 months progression-free time, without relevant subacute or late lung toxicity.
authors.affiliation: UOC Radiodiagnostica e Radioterapia, AOU Policlinico-VE di Catania, 95125, Italy.
authors.forename: Corrado
authors.initials: C
authors.lastname: Spatola
authors.affiliation: UOC Radiodiagnostica e Radioterapia, AOU Policlinico-VE di Catania, 95125, Italy.
authors.forename: Carmelo
authors.initials: C
authors.lastname: Militello
authors.affiliation: UOC Radiodiagnostica e Radioterapia, AOU Policlinico-VE di Catania, 95125, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Tocco
authors.affiliation: UOC Radiodiagnostica e Radioterapia, AOU Policlinico-VE di Catania, 95125, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Salamone
authors.affiliation: UOC Radiodiagnostica e Radioterapia, AOU Policlinico-VE di Catania, 95125, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Raffaele
authors.affiliation: UOC Chirurgia Toracica, AOU Policlinico-VE Catania.
authors.forename: Marcello
authors.initials: M
authors.lastname: Migliore
authors.affiliation: UOC Radiodiagnostica e Radioterapia, AOU Policlinico-VE di Catania, 95125, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Pagana
authors.affiliation: UOC Radiodiagnostica e Radioterapia, AOU Policlinico-VE di Catania, 95125, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Milazzotto
authors.affiliation: UOC Radiodiagnostica e Radioterapia, AOU Policlinico-VE di Catania, 95125, Italy.
authors.forename: Ilenia
authors.initials: I
authors.lastname: Chillura
authors.affiliation: UOC Radioterapia, AOU Policlinico di Messina, 98124, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Pergolizzi
authors.affiliation: UOC Radiodiagnostica e Radioterapia, AOU Policlinico-VE di Catania, 95125, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Privitera
mesh_terms: D000368:Aged; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy*; D008297:Male; D008654:Mesothelioma / Q000175:diagnosis* / Q000532:radiotherapy*; D000086002:Mesothelioma, Malignant; D009364:Neoplasm Recurrence, Local; D010997:Pleural Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy*; D000072078:Positron Emission Tomography Computed Tomography; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects / Q000379:methods; D016896:Treatment Outcome; D047368:Tumor Burden
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: IMRT; malignant pleural mesothelioma; radiation therapy