title: Cascade Reaction of Alkynols and 7-Oxabenzonorbornadienes Involving Transient Hemiketal Group Directed C-H Activation and Synergistic RhIII/ScIIICatalysis.
abstract: As the first cascade C-H activation directed by a transient group, reaction of alkynols and 7-oxabenzonorbornadienes has been achieved via synergistic rhodium and scandium catalysis to afford spirocyclic dihydrobenzo[a]fluorenefurans. This transformation proceeds by a transient hemiketal group directed C-H activation, dehydrative naphthylation, and intramolecular Prins-type cyclization. Mechanistic studies and density functional theory calculations indicate that the rate-determining step is C-H bond cleavage and both the transient hemiketal group and synergistic RhIII/ScIIIcatalysis play key roles.
authors.affiliation: Shanghai Key Laboratory of Functional Materials Chemistry and Key Lab for Advanced Materials, School of Chemistry and Molecular Engineering, East China University of Science and Technology , Meilong Road 130, Shanghai 200237, China.
authors.forename: Deng Yuan
authors.initials: DY
authors.lastname: Li
authors.affiliation: Shanghai Key Laboratory of Functional Materials Chemistry and Key Lab for Advanced Materials, School of Chemistry and Molecular Engineering, East China University of Science and Technology , Meilong Road 130, Shanghai 200237, China.
authors.forename: Liang Liang
authors.initials: LL
authors.lastname: Jiang
authors.affiliation: Shanghai Key Laboratory of Functional Materials Chemistry and Key Lab for Advanced Materials, School of Chemistry and Molecular Engineering, East China University of Science and Technology , Meilong Road 130, Shanghai 200237, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Chen
authors.affiliation: Shanghai Key Laboratory of Functional Materials Chemistry and Key Lab for Advanced Materials, School of Chemistry and Molecular Engineering, East China University of Science and Technology , Meilong Road 130, Shanghai 200237, China.
authors.forename: Zheng Lu
authors.initials: ZL
authors.lastname: Huang
authors.affiliation: Department of Chemistry, South University of Science and Technology of China , Shenzhen 518055, China.
authors.forename: Li
authors.initials: L
authors.lastname: Dang
authors.affiliation: Shanghai Key Laboratory of Functional Materials Chemistry and Key Lab for Advanced Materials, School of Chemistry and Molecular Engineering, East China University of Science and Technology , Meilong Road 130, Shanghai 200237, China.
authors.forename: Xin Yan
authors.initials: XY
authors.lastname: Wu
authors.affiliation: Shanghai Key Laboratory of Functional Materials Chemistry and Key Lab for Advanced Materials, School of Chemistry and Molecular Engineering, East China University of Science and Technology , Meilong Road 130, Shanghai 200237, China.
authors.forename: Pei Nian
authors.initials: PN
authors.lastname: Liu