title: Association between periodontitis and arterial hypertension: A systematic review and meta-analysis.
abstract: BACKGROUND
  Several studies have shown that periodontal diseases are associated with hypertension (HT). However, heterogeneity among populations, diagnosis criteria, and shared risk factors represent some difficulties in terms of interpretation. Therefore, the aim of this study was to determine the magnitude of the association between periodontal diseases and HT.
  
  
  RESULTS
  A systematic review and meta-analysis, including studies published up to June 2016, have been performed. Sixteen studies assessing the association between periodontal diseases and HT have been included. The meta-analysis considering all included studies (moderate to severe periodontitis) showed that the presence of HT was associated with the presence of periodontal diseases (OR, 1.50; 95% CI, 1.27-1.78). To reduce potential bias, a stratified analysis has been performed illustrating the impact of inclusion criteria and adjustments on the magnitude of the association. Interestingly, when only studies with secure diagnosis of severe periodontitis and HT were considered, an OR=1.64 (95% CI, 1.23-2.19) has been measured.
  
  
  CONCLUSIONS
  Periodontal diseases are associated with a higher risk of HT especially for severe periodontitis. However, no conclusions could be made regarding the causative involvement of periodontal diseases mainly due to the reduced number of available prospective studies and remaining questions regarding underlying biological mechanisms.
authors.affiliation: Université de Strasbourg, Faculté de Chirurgie Dentaire, Department of Periodontology, Strasbourg, France.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Martin-Cabezas
authors.affiliation: Université de Strasbourg, Faculté de Chirurgie Dentaire, Department of Periodontology, Strasbourg, France.
authors.forename: Narendra
authors.initials: N
authors.lastname: Seelam
authors.affiliation: Université de Strasbourg, Faculté de Chirurgie Dentaire, Department of Periodontology, Strasbourg, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Petit
authors.affiliation: University of Lille, Dental Faculty, Department of Periodontology.
authors.forename: Kévimy
authors.initials: K
authors.lastname: Agossa
authors.affiliation: Service Hypertension, maladies vasculaires et pharmacologie clinique, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Gaertner
authors.affiliation: Université de Strasbourg, Faculté de Chirurgie Dentaire, Department of Periodontology, Strasbourg, France; INSERM 1109 «Osteoarticular & Dental Regenerative Nanomedicine», Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France.
authors.forename: Henri
authors.initials: H
authors.lastname: Tenenbaum
authors.affiliation: Université de Strasbourg, Faculté de Chirurgie Dentaire, Department of Periodontology, Strasbourg, France; INSERM 1109 «Osteoarticular & Dental Regenerative Nanomedicine», Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Davideau
authors.affiliation: Université de Strasbourg, Faculté de Chirurgie Dentaire, Department of Periodontology, Strasbourg, France; INSERM 1109 «Osteoarticular & Dental Regenerative Nanomedicine», Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France. Electronic address: huck.olivier@gmail.com.
authors.forename: Olivier
authors.initials: O
authors.lastname: Huck
mesh_terms: D006801:Humans; D006973:Hypertension / Q000209:etiology*; D010518:Periodontitis / Q000150:complications*; D012307:Risk Factors