title: An Updated Review of ISCOMSTM and ISCOMATRIXTM Vaccines.
abstract: The need for the improvement of vaccine potency as well as reducing toxicity in healthy recipients has motivated studies of the formulation of vaccines regarding control of how, when, and where antigens and adjuvants encounter immune cells and other cells/tissues following vaccine administration. Immunostimulatory complexes (ISCOMs) and ISCOMATRIXTM adjuvants are versatile and flexible systems with various phospholipids and saponin components. They are being used in novel vaccines for either infectious diseases or cancer. This article presents a brief review of the latest developments using such adjuvants and possible new applications.
authors.affiliation: Instituto de Inmunología, Facultad de Medicina, Universidad Central de Venezuela, Apartado 50109, Caracas 1050-A, Venezuela.
authors.forename: Alexis
authors.initials: A
authors.lastname: Garcia
authors.forename: Diego
authors.initials: D
authors.lastname: Lema
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D003141:Communicable Diseases / Q000188:drug therapy*; D006801:Humans; D016882:ISCOMs / Q000276:immunology / Q000627:therapeutic use*; D009369:Neoplasms / Q000188:drug therapy*; D014612:Vaccines / Q000276:immunology / Q000627:therapeutic use*
chemical_list: D000276:Adjuvants, Immunologic; D016882:ISCOMs; D014612:Vaccines
keywords: ISCOMATRIX™; ISCOMs; adaptive
  immune response; adjuvant; immune response; immunogenicity; innate immune response; safety; vaccine