title: Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model.
abstract: The aim of this tutorial is to introduce the fundamental concepts of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling with a special focus on their practical implementation in a typical PBPK model building workflow. To illustrate basic steps in PBPK model building, a PBPK model for ciprofloxacin will be constructed and coupled to a pharmacodynamic model to simulate the antibacterial activity of ciprofloxacin treatment.
authors.affiliation: Bayer Technology Services, Leverkusen, Germany.
authors.forename: L
authors.initials: L
authors.lastname: Kuepfer
authors.affiliation: Bayer Technology Services, Leverkusen, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Niederalt
authors.affiliation: Bayer Technology Services, Leverkusen, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Wendl
authors.affiliation: Bayer Technology Services, Leverkusen, Germany.
authors.forename: J-F
authors.initials: JF
authors.lastname: Schlender
authors.affiliation: Bayer HealthCare, Wuppertal, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Willmann
authors.affiliation: Bayer HealthCare, Wuppertal, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Lippert
authors.affiliation: Bayer Technology Services, Leverkusen, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Block
authors.affiliation: Bayer Technology Services, Leverkusen, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Eissing
authors.affiliation: Bayer Technology Services, Leverkusen, Germany. donato.teutonico@servier.com.
authors.forename: D
authors.initials: D
authors.lastname: Teutonico
mesh_terms: D000818:Animals; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D010599:Pharmacokinetics; D018570:Risk Assessment; D014018:Tissue Distribution