title: [SCREENING OF WILD SPREAD AND CULTIVATED OF BUXUS SPECIES GROWING IN GEORGIA ON THE CONTENT OF ALKALOIDS AND BIOLOGICAL ACTIVITY].
abstract: Georgian flora is represented by about 4150 plant species. Many important alkaloid-containing plant species and among of them are species Buxus L. of genus in Adjara. The aims of the research were: sequential screening of the plants for the consistence of alkaloids; Study of anatomical characteristics of Buxus colchica Pojark. and revealing of specific pharmacological activity of steroidal alkaloids. The objects of research were B. colchica, B. balearika and B. sempervirens, growing in Adjara (Georgia), collected in active phase of flowering of the plants. There were revealed 370 species of alkaloid containing plants. Sum of alkaloids and crude aqueous extract have spasmolitic and antihistaminic activity. Experimental anatomical research of diagnostic characteristics of the bines showed the existence of monocyclic transient system with fiber like tracheids, dorsoventral mesophyll of the leaves; the structure for the upper part of epidermis is linear and the lower part is curved, type of stomata is paracitic.
authors.affiliation: Tbilisi State Medical University, Iovel Kutateladze Institute of Pharmacochemistry, Georgia.
authors.forename: N
authors.initials: N
authors.lastname: Vachnadze
authors.affiliation: Tbilisi State Medical University, Iovel Kutateladze Institute of Pharmacochemistry, Georgia.
authors.forename: Q
authors.initials: Q
authors.lastname: Mchedlidze
authors.affiliation: Tbilisi State Medical University, Iovel Kutateladze Institute of Pharmacochemistry, Georgia.
authors.forename: J
authors.initials: J
authors.lastname: Novikova
authors.affiliation: Tbilisi State Medical University, Iovel Kutateladze Institute of Pharmacochemistry, Georgia.
authors.forename: T
authors.initials: T
authors.lastname: Suladze
authors.affiliation: Tbilisi State Medical University, Iovel Kutateladze Institute of Pharmacochemistry, Georgia.
authors.forename: V
authors.initials: V
authors.lastname: Vachnadze
mesh_terms: D000470:Alkaloids / Q000032:analysis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D031235:Buxus / Q000033:anatomy & histology / Q000737:chemistry*; D005260:Female; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D058865:Introduced Species; D008297:Male; D051379:Mice; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D018515:Plant Leaves / Q000033:anatomy & histology / Q000737:chemistry; D018520:Plant Shoots / Q000033:anatomy & histology / Q000737:chemistry; D051381:Rats; D013045:Species Specificity; D013256:Steroids / Q000032:analysis* / Q000494:pharmacology / Q000633:toxicity
chemical_list: D000470:Alkaloids; D010936:Plant Extracts; D013256:Steroids