title: Decreased Network Efficiency in Benign Epilepsy with Centrotemporal Spikes.
abstract: Purpose To investigate the functional connectome alterations in benign epilepsy with centrotemporal spikes with respect to the occurrence of interictal epileptic discharges (IEDs) during functional magnetic resonance (MR) imaging. Materials and Methods This prospective study was approved by the local institutional review board and was HIPAA compliant. All participants were consecutively enrolled with written informed consent. Forty-three right-handed patients were classified into IED (n = 20, 13 girls and seven boys; mean age ± standard deviation, 9.00 years ± 1.95) and non-IED (n = 23, 11 girls and 12 boys; mean age, 10.22 years ± 2.13) groups on the basis of electroencephalographic data simultaneously recorded during resting-state functional MR imaging at 3.0 T. The functional connectome features (estimated with graph theoretical analysis) in patient groups and control subjects who were matched for sex, age, and education level (n = 28, all right-handed, 13 girls and 15 boys; mean age, 10.00 years ± 2.31) were compared by using one-way analysis of variance. Results Patients with IEDs and those without IEDs showed consistently abnormal global topology in their functional networks (ie, decreased global efficiency; P < .05) relative to that of control subjects, with no differences between the two patient groups (P > .05). Decreased regional efficiency and connectivity strength were observed in the patients with IEDs and those without (mainly in the perirolandic and frontal areas) relative to control subjects (P < .05). Moreover, the altered functional features significantly correlated with clinical characteristics (ie, disease duration and age at symptom onset, P < .05). Conclusion These findings suggest that decreased global and regional efficiency are prominent functional deficits in children with benign epilepsy with centrotemporal spikes and can be readily identified with resting-state functional MR imaging, irrespective of IEDs.©RSNA, 2016 Online supplemental material is available for this article.
authors.affiliation: From the Laboratory of Cognitive Neuropsychology, Department of Medical Psychology, Anhui Medical University, Hefei, China (G.J.J.); Collaborative Innovation Centre of Neuropsychiatric Disorders and Mental Health, Anhui Province, China (G.J.J.); Department of Psychology, School of Education (G.J.J., H.H.M., W.L.), and Center for Cognition and Brain Disorders and the Affiliated Hospital (G.J.J., H.H.M., W.L.), Hangzhou Normal University, Hangzhou, China; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, China (G.J.J., H.H.M., W.L.); Departments of Psychiatry (Y.Y.) and Neurology (Z.J.W., Y.L.T.), the Second Affiliated Hospital of Medial College, Zhejiang University, Zhejiang, China; and Center for Information in BioMedicine, Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China (W.L.).
authors.forename: Gong-Jun
authors.initials: GJ
authors.lastname: Ji
authors.affiliation: From the Laboratory of Cognitive Neuropsychology, Department of Medical Psychology, Anhui Medical University, Hefei, China (G.J.J.); Collaborative Innovation Centre of Neuropsychiatric Disorders and Mental Health, Anhui Province, China (G.J.J.); Department of Psychology, School of Education (G.J.J., H.H.M., W.L.), and Center for Cognition and Brain Disorders and the Affiliated Hospital (G.J.J., H.H.M., W.L.), Hangzhou Normal University, Hangzhou, China; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, China (G.J.J., H.H.M., W.L.); Departments of Psychiatry (Y.Y.) and Neurology (Z.J.W., Y.L.T.), the Second Affiliated Hospital of Medial College, Zhejiang University, Zhejiang, China; and Center for Information in BioMedicine, Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China (W.L.).
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.affiliation: From the Laboratory of Cognitive Neuropsychology, Department of Medical Psychology, Anhui Medical University, Hefei, China (G.J.J.); Collaborative Innovation Centre of Neuropsychiatric Disorders and Mental Health, Anhui Province, China (G.J.J.); Department of Psychology, School of Education (G.J.J., H.H.M., W.L.), and Center for Cognition and Brain Disorders and the Affiliated Hospital (G.J.J., H.H.M., W.L.), Hangzhou Normal University, Hangzhou, China; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, China (G.J.J., H.H.M., W.L.); Departments of Psychiatry (Y.Y.) and Neurology (Z.J.W., Y.L.T.), the Second Affiliated Hospital of Medial College, Zhejiang University, Zhejiang, China; and Center for Information in BioMedicine, Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China (W.L.).
authors.forename: Huan-Huan
authors.initials: HH
authors.lastname: Miao
authors.affiliation: From the Laboratory of Cognitive Neuropsychology, Department of Medical Psychology, Anhui Medical University, Hefei, China (G.J.J.); Collaborative Innovation Centre of Neuropsychiatric Disorders and Mental Health, Anhui Province, China (G.J.J.); Department of Psychology, School of Education (G.J.J., H.H.M., W.L.), and Center for Cognition and Brain Disorders and the Affiliated Hospital (G.J.J., H.H.M., W.L.), Hangzhou Normal University, Hangzhou, China; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, China (G.J.J., H.H.M., W.L.); Departments of Psychiatry (Y.Y.) and Neurology (Z.J.W., Y.L.T.), the Second Affiliated Hospital of Medial College, Zhejiang University, Zhejiang, China; and Center for Information in BioMedicine, Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China (W.L.).
authors.forename: Zhong-Jin
authors.initials: ZJ
authors.lastname: Wang
authors.affiliation: From the Laboratory of Cognitive Neuropsychology, Department of Medical Psychology, Anhui Medical University, Hefei, China (G.J.J.); Collaborative Innovation Centre of Neuropsychiatric Disorders and Mental Health, Anhui Province, China (G.J.J.); Department of Psychology, School of Education (G.J.J., H.H.M., W.L.), and Center for Cognition and Brain Disorders and the Affiliated Hospital (G.J.J., H.H.M., W.L.), Hangzhou Normal University, Hangzhou, China; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, China (G.J.J., H.H.M., W.L.); Departments of Psychiatry (Y.Y.) and Neurology (Z.J.W., Y.L.T.), the Second Affiliated Hospital of Medial College, Zhejiang University, Zhejiang, China; and Center for Information in BioMedicine, Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China (W.L.).
authors.forename: Ye-Lei
authors.initials: YL
authors.lastname: Tang
authors.affiliation: From the Laboratory of Cognitive Neuropsychology, Department of Medical Psychology, Anhui Medical University, Hefei, China (G.J.J.); Collaborative Innovation Centre of Neuropsychiatric Disorders and Mental Health, Anhui Province, China (G.J.J.); Department of Psychology, School of Education (G.J.J., H.H.M., W.L.), and Center for Cognition and Brain Disorders and the Affiliated Hospital (G.J.J., H.H.M., W.L.), Hangzhou Normal University, Hangzhou, China; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, China (G.J.J., H.H.M., W.L.); Departments of Psychiatry (Y.Y.) and Neurology (Z.J.W., Y.L.T.), the Second Affiliated Hospital of Medial College, Zhejiang University, Zhejiang, China; and Center for Information in BioMedicine, Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China (W.L.).
authors.forename: Wei
authors.initials: W
authors.lastname: Liao
mesh_terms: D000293:Adolescent; D002540:Cerebral Cortex; D002648:Child; D063132:Connectome / Q000379:methods*; D003430:Cross-Sectional Studies; D004569:Electroencephalography / Q000379:methods; D019305:Epilepsy, Rolandic / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009415:Nerve Net / Q000000981:diagnostic imaging / Q000503:physiopathology; D011446:Prospective Studies