title: Expressions of NDRG1, VEGF and Ki-67 in Condyloma Acuminatum.
abstract: The objective of this study was to explore the expressions and significance of NDRG1 (N-myc downregulated gene family 1), VEGF (vascular endothelial growth factor) and Ki-67 in lesions of Condyloma Acuminatum (CA). Immunohistochemistry was adopted to measure the expressions of NDRG1, VEGF and Ki-67 in 48 cases of CA and 18 normal skin controls. The positive rates of NDRG1, VEGF and Ki-67 were 63. 83.33% (40/48), 93.75% (45/48) and 85.42% (41/48) in the CA tissues, and 27.78% (5/18), 94.44%(17/18) and 61.11% (11/18) in the controls, respectively. The intensities of the expressions of NDRG1, VEGF and Ki-67 in CA tissues were significantly higher than those in the controls. There were significant differences both in the positive rates and the expression intensities of NDRG1, VEGF and Ki-67 between the two groups (P less than0.05). The Spearmans Rank-Order Correlation analysis indicated that the expressions of NDRG1 protein and VEGF protein were positively correlated by the Spearmans Rank-Order Correlation analysis (r = 0.346, P=0.016). For the CA tissues with high expressions of NDRG1 and VEGF, NDRG1 and VEGF influenced both the occurrence and development of CA.
authors.affiliation: Department of Dermatology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou City, PR China.
authors.forename: G W
authors.initials: GW
authors.lastname: Yin
authors.affiliation: Department of Dermatology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou City, PR China.
authors.forename: Y
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Department of Dermatology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou City, PR China.
authors.forename: B
authors.initials: B
authors.lastname: Jin
mesh_terms: D000293:Adolescent; D000328:Adult; D018797:Cell Cycle Proteins / Q000096:biosynthesis* / Q000235:genetics; D002455:Cell Division; D003218:Condylomata Acuminata / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005786:Gene Expression Regulation; D005831:Genital Diseases, Female / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005832:Genital Diseases, Male / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000096:biosynthesis* / Q000235:genetics; D019394:Ki-67 Antigen / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis* / Q000235:genetics; D055815:Young Adult; D000099259:N-myc Downstream-Regulated Gene 1 Protein
chemical_list: D018797:Cell Cycle Proteins; D047908:Intracellular Signaling Peptides and Proteins; D019394:Ki-67 Antigen; D042461:Vascular Endothelial Growth Factor A; D000099259:N-myc Downstream-Regulated Gene 1 Protein; C467484:VEGFA protein, human