title: Quercetin induces mitochondrial biogenesis in experimental traumatic brain injury via the PGC-1α signaling pathway.
abstract: Quercetin, a dietary flavonoid used as a food supplement, has been found to have protective effect against mitochondria damage after traumatic brain injury (TBI) in mice. However, the mechanisms underlying these effects are still not well understood. The aim of the present study was to investigate the effect of quercetin on the potential mechanism mediating these effects in the weight-drop model of TBI in male mice that were treated with quercetin or vehicle via intraperitoneal injection administration 30 min after TBI. Brain samples were collected 24 h later for analysis. Quercetin treatment upregulated the expression of PGC-1α and restored the level of cytochrome c, malondialdehyde (MDA) and superoxide dismutase (SOD). These results demonstrate that quercetin improves mitochondrial function in mice by improving the level of PGC-1α following TBI.
authors.affiliation: Department of Neurosurgery, Jinling Hospital, Medical School of Nanjing University No. 305 East Zhongshan Road, Nanjing 210002, Jiangsu, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Jinling Hospital, Medical School of Nanjing University No. 305 East Zhongshan Road, Nanjing 210002, Jiangsu, China.
authors.forename: Handong
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Jinling Hospital, Medical School of Nanjing University No. 305 East Zhongshan Road, Nanjing 210002, Jiangsu, China.
authors.forename: Yongyue
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Neurosurgery, Jinling Hospital, Medical School of Nanjing University No. 305 East Zhongshan Road, Nanjing 210002, Jiangsu, China.
authors.forename: Liwen
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Jinling Hospital, Medical School of Nanjing University No. 305 East Zhongshan Road, Nanjing 210002, Jiangsu, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Tang
authors.affiliation: Department of Neurosurgery, Jinling Hospital, Medical School of Nanjing University No. 305 East Zhongshan Road, Nanjing 210002, Jiangsu, China.
authors.forename: Guodao
authors.initials: G
authors.lastname: Wen
authors.affiliation: Department of Neurosurgery, Jinling Hospital, Medical School of Nanjing University No. 305 East Zhongshan Road, Nanjing 210002, Jiangsu, China.
authors.forename: Youqing
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Neurosurgery, Jinling Hospital, Medical School of Nanjing University No. 305 East Zhongshan Road, Nanjing 210002, Jiangsu, China.
authors.forename: Zong
authors.initials: Z
authors.lastname: Zhuang
authors.affiliation: Department of Neurosurgery, Jinling Hospital, Medical School of Nanjing University No. 305 East Zhongshan Road, Nanjing 210002, Jiangsu, China.
authors.forename: Mengliang
authors.initials: M
authors.lastname: Zhou
authors.affiliation: Department of Neurosurgery, Jinling Hospital, Medical School of Nanjing University No. 305 East Zhongshan Road, Nanjing 210002, Jiangsu, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Mao
authors.affiliation: Department of Neurosurgery, Jinling Hospital, Medical School of Nanjing University No. 305 East Zhongshan Road, Nanjing 210002, Jiangsu, China.
authors.forename: Youwu
authors.initials: Y
authors.lastname: Fan
keywords: PGC-1α; Quercetin; mitochondria; traumatic brain injury