title: Baseline Fourier-Domain Optical Coherence Tomography Structural Risk Factors for Visual Field Progression in the Advanced Imaging for Glaucoma Study.
abstract: OBJECTIVE
  To identify baseline structural parameters that predict the progression of visual field (VF) loss in patients with open-angle glaucoma.
  
  
  METHODS
  Multicenter cohort study.
  
  
  METHODS
  Participants from the Advanced Imaging for Glaucoma (AIG) study were enrolled and followed up. VF progression is defined as either a confirmed progression event on Humphrey Progression Analysis or a significant (P < .05) negative slope for VF index (VFI). Fourier-domain optical coherence tomography (FDOCT) was used to measure optic disc, peripapillary retinal nerve fiber layer (NFL), and macular ganglion cell complex (GCC) thickness parameters.
  
  
  RESULTS
  A total of 277 eyes of 188 participants were followed up for 3.7 ± 2.1 years. VF progression was observed in 83 eyes (30%). Several baseline NFL and GCC parameters, but not disc parameters, were found to be significant predictors of progression on univariate Cox regression analysis. The most accurate single predictors were the GCC focal loss volume (FLV), followed closely by NFL-FLV. An abnormal GCC-FLV at baseline increased risk of progression by a hazard ratio of 3.1. Multivariate Cox analysis showed that combining age and central corneal thickness with GCC-FLV in a composite index called "Glaucoma Composite Progression Index" (GCPI) further improved the accuracy of progression prediction. GCC-FLV and GCPI were both found to be significantly correlated with the annual rate of change in VFI.
  
  
  CONCLUSIONS
  Focal GCC and NFL loss as measured by FDOCT are the strongest predictors for VF progression among the measurements considered. Older age and thinner central corneal thickness can enhance the predictive power using the composite risk model.
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, Oregon.
authors.forename: Xinbo
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Doheny Eye Center and David Geffen School of Medicine at UCLA, Los Angeles, California.
authors.forename: Anna
authors.initials: A
authors.lastname: Dastiridou
authors.affiliation: Doheny Eye Center and David Geffen School of Medicine at UCLA, Los Angeles, California.
authors.forename: Brian A
authors.initials: BA
authors.lastname: Francis
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, Oregon.
authors.forename: Ou
authors.initials: O
authors.lastname: Tan
authors.affiliation: Department of Ophthalmology, University of Southern California Keck School of Medicine, Los Angeles, California.
authors.forename: Rohit
authors.initials: R
authors.lastname: Varma
authors.affiliation: Bascom Palmer Eye Institute, University of Miami, Miami, Florida.
authors.forename: David S
authors.initials: DS
authors.lastname: Greenfield
authors.affiliation: Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
authors.forename: Joel S
authors.initials: JS
authors.lastname: Schuman
authors.affiliation: Bascom Palmer Eye Institute, University of Miami, Miami, Florida.
authors.forename: Mitra
authors.initials: M
authors.lastname: Sehi
authors.affiliation: Doheny Eye Center and David Geffen School of Medicine at UCLA, Los Angeles, California.
authors.forename: Vikas
authors.initials: V
authors.lastname: Chopra
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, Oregon. Electronic address: davidhuang@alum.mit.edu.
authors.forename: David
authors.initials: D
authors.lastname: Huang
mesh_terms: D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005583:Fourier Analysis; D005901:Glaucoma / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008266:Macula Lutea / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000000981:diagnostic imaging*; D012307:Risk Factors; D012607:Scotoma / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000379:methods*; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology*