title: [Significance of SATB2 in the pathologic diagnosis of osteosarcoma].
abstract: OBJECTIVE
  To investigate the role of SATB2 in the pathological diagnosis and differential diagnosis of osteosarcoma.
  
  
  METHODS
  Immunostaining of SATB2 was performed in 47 cases of osteosarcomas, 5 osteoblastomas, 4 fibrous dysplasias, 5 myositis ossificans, 10 chondroblastomas, 8 chondrosarcomas, 5 Ewing sarcomas, 5 undifferentiated pleomorphic sarcomas, 6 fibrosarcomas and 2 leiomyosarcomas.
  
  
  RESULTS
  All osteoblastomas (5/5) and myositis ossificans (5/5), 83.0%(39/47) of osteosarcomas and 2/10 of chondroblastomas showed nuclear immunoreactivity for SATB2. SATB2 staining was negative in all cases of fibrous dysplasia, chondrosarcomas, Ewing sarcomas and all bone primary spindle cell sarcomas(undifferentiated pleomorphic sarcoma, fibrosarcoma and leiomyosarcoma).
  
  
  CONCLUSIONS
  SATB2 is a reliable osteoblastic marker for differential diagnosis of osteosarcoma and non-osteoid sarcoma, although with a limited role in separating osteosarcoma from non-malignant osteoblastic lesions.
authors.affiliation: Department of Orthopedics, the First Affiliated Hospital of Anhui Medical University, Hefei 230032, China.
authors.forename: M
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Pathology, Anhui Medical University, Hefei 230032, China.
authors.forename: Y P
authors.initials: YP
authors.lastname: Cai
authors.forename: K Y
authors.initials: KY
authors.lastname: Lu
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.forename: X
authors.initials: X
authors.lastname: Zhu
authors.forename: Y
authors.initials: Y
authors.lastname: Yin
authors.forename: J
authors.initials: J
authors.lastname: Tang
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D001859:Bone Neoplasms / Q000737:chemistry / Q000473:pathology*; D002804:Chondroblastoma / Q000737:chemistry / Q000473:pathology; D002813:Chondrosarcoma / Q000737:chemistry / Q000473:pathology; D003937:Diagnosis, Differential; D005354:Fibrosarcoma / Q000737:chemistry / Q000473:pathology; D006801:Humans; D007890:Leiomyosarcoma / Q000737:chemistry / Q000473:pathology; D036961:Matrix Attachment Region Binding Proteins / Q000032:analysis*; D018215:Osteoblastoma / Q000737:chemistry / Q000473:pathology; D012516:Osteosarcoma / Q000737:chemistry / Q000473:pathology*; D012509:Sarcoma / Q000737:chemistry / Q000473:pathology; D014157:Transcription Factors / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; D036961:Matrix Attachment Region Binding Proteins; C521297:SATB2 protein, human; D014157:Transcription Factors