title: The absence of the SOD1 gene causes abnormal monoaminergic neurotransmission and motivational impairment-like behavior in mice.
abstract: Copper/zinc superoxide dismutase (SOD1), a primary anti-oxidative enzyme, protects cells against oxidative stress. We report herein on a comparison of behavioral and neurobiological changes between SOD1 knockout (KO) and wild-type mice, in an attempt to assess the role of SOD1 in brain functions. SOD1 KO mice exhibited impaired motivational behavior in both shuttle-box learning and three-chamber social interaction tests. High levels of dopamine transporter protein and an acceleration of serotonin turnover were also detected in the cerebrums of the SOD1 KO mice. These findings suggest that SOD1 deficiency disturbs monoaminergic neurotransmission leading to a decrease in motivational behavior.
authors.affiliation: a Department of Biochemistry , Hyogo College of Medicine , Nishinomiya , Japan.
authors.forename: Daisaku
authors.initials: D
authors.lastname: Yoshihara
authors.affiliation: a Department of Biochemistry , Hyogo College of Medicine , Nishinomiya , Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Fujiwara
authors.affiliation: b Department of Pharmacology , Hyogo College of Medicine , Nishinomiya , Japan.
authors.forename: Nobue
authors.initials: N
authors.lastname: Kitanaka
authors.affiliation: b Department of Pharmacology , Hyogo College of Medicine , Nishinomiya , Japan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Kitanaka
authors.affiliation: a Department of Biochemistry , Hyogo College of Medicine , Nishinomiya , Japan.
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Sakiyama
authors.affiliation: a Department of Biochemistry , Hyogo College of Medicine , Nishinomiya , Japan.
authors.forename: Hironobu
authors.initials: H
authors.lastname: Eguchi
authors.affiliation: b Department of Pharmacology , Hyogo College of Medicine , Nishinomiya , Japan.
authors.forename: Motohiko
authors.initials: M
authors.lastname: Takemura
authors.affiliation: a Department of Biochemistry , Hyogo College of Medicine , Nishinomiya , Japan.
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018384:Oxidative Stress; D017382:Reactive Oxygen Species; D013315:Stress, Psychological; D013482:Superoxide Dismutase / Q000235:genetics* / Q000378:metabolism; D009435:Synaptic Transmission
chemical_list: D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase
keywords: SOD1; dopamine transporter; monoamine; oxidative stress; shuttle-box; sociability