title: Cats in Positive Energy Balance Have Lower Rates of Adipose Gain When Fed Diets Containing 188 versus 121 ppm L-Carnitine.
abstract: L-carnitine (LC) is included in select adult feline diets for weight management. This study investigated whether feeding adult cats with diets containing either 188 ppm of LC (LC188) or 121 ppm of LC (LC121) and feeding them 120% of maintenance energy requirement (MER) resulted in differences in total energy expenditure (EE), metabolic fuel selection, BW, body composition, and behavior. Cats (n = 20, 4 ± 1.2 yrs) were stratified for BCS and randomly assigned to one of two dietary treatments and fed for 16 weeks. BW was measured weekly, and indirect calorimetry, body composition, physical activity, play motivation, and cognition were measured at baseline and throughout the study. A mixed, repeated measures, ANCOVA model was used. Cats in both treatments gained BW (P < 0.05) throughout the study, with no differences between treatments at any time point (P > 0.05). There were no differences in body composition between groups at baseline; however, body fat (g) and body fat : lean mass ratio were greater in cats fed LC121 in contrast to cats fed LC188 (P < 0.05) on week 16. No other outcomes differed between treatments (P > 0.05). Supplying dietary LC at a dose of at least 188 ppm may be beneficial for the health and well-being of cats fed above MER.
authors.affiliation: The Iams Company, Mars PetCare, 6571 State Route 503 North, Lewisburg, OH 45338, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Gooding
authors.affiliation: The Iams Company, Mars PetCare, 6571 State Route 503 North, Lewisburg, OH 45338, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Minikhiem
authors.affiliation: The Iams Company, Mars PetCare, 6571 State Route 503 North, Lewisburg, OH 45338, USA; Centre for Nutrition Modelling, Department of Animal Biosciences, University of Guelph, 50 Stone Road East, Guelph, ON, Canada N1G 2W1.
authors.forename: A K
authors.identifier: 0000-0002-2584-4774
authors.initials: AK
authors.lastname: Shoveller
mesh_terms: D050154:Adiposity; D000821:Animal Feed; D000818:Animals; D002331:Carnitine / Q000008:administration & dosage*; D002415:Cats; D004032:Diet / Q000662:veterinary; D004734:Energy Metabolism; D009765:Obesity / Q000662:veterinary*
chemical_list: D002331:Carnitine