title: The Cajal body and the nucleolus: "In a relationship" or "It's complicated"?
abstract: From their initial identification as 'nucleolar accessory bodies' more than a century ago, the relationship between Cajal bodies and nucleoli has been a subject of interest and controversy. In this review, we seek to place recent developments in the understanding of the physical and functional relationships between the 2 structures in the context of historical observations. Biophysical models of nuclear body formation, the molecular nature of CB/nucleolus interactions and the increasing list of joint roles for CBs and nucleoli, predominantly in assembling ribonucleoprotein (RNP) complexes, are discussed.
authors.affiliation: a Department of Cellular and Molecular Medicine , Ottawa Institute of Systems Biology, University of Ottawa , Ottawa , ON , Canada.
authors.forename: Laura
authors.identifier: 0000-0002-7619-2841
authors.initials: L
authors.lastname: Trinkle-Mulcahy
authors.affiliation: b BSRC Complex, School of Biology, University of St Andrews , UK.
authors.forename: Judith E
authors.identifier: 0000-0003-0345-6508
authors.initials: JE
authors.lastname: Sleeman
mesh_terms: D000818:Animals; D002466:Cell Nucleolus / Q000378:metabolism*; D020541:Coiled Bodies / Q000378:metabolism*; D006801:Humans; D009154:Mutation; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D011485:Protein Binding; D034622:RNA Interference; D012323:RNA Processing, Post-Transcriptional; D012342:RNA, Small Nuclear / Q000235:genetics / Q000378:metabolism; D017411:Ribonucleoproteins, Small Nuclear / Q000378:metabolism; D059505:Telomere Homeostasis
chemical_list: D009687:Nuclear Proteins; D012342:RNA, Small Nuclear; D017411:Ribonucleoproteins, Small Nuclear; C068921:p80-coilin
keywords: Cajal body; coilin; non-coding RNAs; nuclear bodies; nuclear structure; nucleolus; phase separation; snRNPs; snoRNPs; telomerase