title: Chemokine Patterns in Children with Acute Bacterial Infections.
abstract: Chemokines are chemotactic cytokines that are mainly involved in the migratory patterns of immune cells. Few studies have evaluated the levels of chemokines in children with acute bacterial infections. The aim of this study was to evaluate the serum levels of chemokines MCP-1, RANTES, MIG and IP-10 in children with sepsis, community-acquired pneumonia (CAP) and skin abscess. Serum levels of MCP-1, RANTES, MIG and IP-10 were measured in 37 children with sepsis, 27 children with CAP, 25 children with skin abscess and 20 controls with no signs of infection. Patients with sepsis, CAP and skin abscess had higher concentrations of RANTES compared to controls (P = 0.0057, P = 0.0004 and P = 0.0108, respectively). IP-10 values were higher in patients with sepsis compared to children with skin abscess (P = 0.0075). However, MCP-1 levels were lower in septic patients compared to controls (P = 0.0136). There was no difference on MIG concentrations between the groups. Our original findings observed that RANTES was consistently elevated in all types of infections suggesting this chemokine may play an important role in the pathogenesis of bacterial infection. Additionally, patients with sepsis had a unique pattern of response with high levels of IP-10 but low levels of MCP-1, which should be further explored as the markers of disease severity.
authors.affiliation: Instituto de Medicina Integral Prof Fernando Figueira, Recife, Brazil.|Faculdade de Ciências Médicas, Universidade de Pernambuco, Recife, Brazil.
authors.forename: N V
authors.initials: NV
authors.lastname: Cavalcanti
authors.affiliation: Instituto de Medicina Integral Prof Fernando Figueira, Recife, Brazil.|Laboratório de Pesquisa Translacional Prof CA Hart, IMIP, Recife, Brasil.
authors.forename: L C
authors.initials: LC
authors.lastname: Torres
authors.affiliation: Laboratório de Pesquisa Translacional Prof CA Hart, IMIP, Recife, Brasil.
authors.forename: M C
authors.initials: MC
authors.lastname: da Matta
authors.affiliation: Faculdade Pernambucana de Saúde, Recife, Brasil.
authors.forename: C D
authors.initials: CD
authors.lastname: Lindoso
authors.affiliation: Faculdade Pernambucana de Saúde, Recife, Brasil.
authors.forename: L N
authors.initials: LN
authors.lastname: A Carvalho
authors.affiliation: Instituto de Medicina Integral Prof Fernando Figueira, Recife, Brazil.
authors.forename: M C M B
authors.initials: MC
authors.lastname: Duarte
authors.affiliation: Instituto de Medicina Integral Prof Fernando Figueira, Recife, Brazil.|Faculdade de Ciências Médicas, Universidade de Pernambuco, Recife, Brazil.
authors.forename: J B
authors.initials: JB
authors.lastname: Correia
mesh_terms: D000038:Abscess / Q000276:immunology*; D000208:Acute Disease; D018932:Chemokine CCL2 / Q000097:blood; D018946:Chemokine CCL5 / Q000097:blood; D054357:Chemokine CXCL10 / Q000097:blood; D054370:Chemokine CXCL9 / Q000097:blood; D018925:Chemokines / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000276:immunology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D018410:Pneumonia, Bacterial / Q000276:immunology*; D011446:Prospective Studies; D018805:Sepsis / Q000276:immunology*; D017192:Skin Diseases, Bacterial / Q000276:immunology*
chemical_list: C111835:CCL2 protein, human; C483024:CCL5 protein, human; D018932:Chemokine CCL2; D018946:Chemokine CCL5; D054357:Chemokine CXCL10; D054370:Chemokine CXCL9; D018925:Chemokines