title: The Role of MicroRNA and LncRNA-MicroRNA Interactions in Regulating Ischemic Heart Disease.
abstract: Approximately 2% of the human genome consists of protein-coding regions. Therefore, the majority of transcripts are noncoding RNAs, such as microRNA (miRNA) and long noncoding RNAs (lncRNAs). In ischemic heart disease, the majority of miRNAs are repressors or destabilizers of target messenger RNAs. The lncRNAs are a second class of noncoding RNAs that have recently gained attention for their roles in heart disease and in regulating the functions of miRNA. In this review, we summarize the role of miRNA in pathological cardiac hypertrophy and myocardial infarction. In addition, we discuss the functional interactions of miRNA and lncRNA and its impact on these ischemic heart diseases.
authors.affiliation: 1 Center for Developmental Cardiology, Institute for Translational Medicine, Qingdao University, Qingdao, China.
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.affiliation: 1 Center for Developmental Cardiology, Institute for Translational Medicine, Qingdao University, Qingdao, China.
authors.forename: Murugavel
authors.initials: M
authors.lastname: Ponnusamy
authors.affiliation: 1 Center for Developmental Cardiology, Institute for Translational Medicine, Qingdao University, Qingdao, China.
authors.forename: Meng-Peng
authors.initials: MP
authors.lastname: Li
authors.affiliation: 1 Center for Developmental Cardiology, Institute for Translational Medicine, Qingdao University, Qingdao, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Wang
authors.affiliation: 1 Center for Developmental Cardiology, Institute for Translational Medicine, Qingdao University, Qingdao, China.
authors.forename: Pei-Feng
authors.initials: PF
authors.lastname: Li
keywords: lncRNA; microRNA; microRNA–lncRNA interaction; myocardial infarction; pathological cardiac hypertrophy