title: Vesical clear cell adenocarcinoma arising from endometriosis: A mullerian tumor, indistinguishable from ovarian clear cell adenocarcinoma.
abstract: Endometriosis is associated with increased rates of ovarian, particularly clear cell, adenocarcinomas. Malignant transformation of ovarian endometriosis is most common but rare cases have been reported in the bladder, abdominal wall, diaphragm, and rectum. We present the case of a 44-year-old female with vesical clear cell adenocarcinoma arising in a background of endometriosis in the absence of other pelvic endometriosis. The malignancy was diagnosed on transurethral resection of bladder tumor and managed with radical surgery. Histology and immunohistochemical findings were consistent mullerian origin and indistinguishable from similar tumors arising in the female genital tract. Extrapolating from the gynecologic literature, the recommendation was made for adjuvant chemotherapy. Further studies are needed to clarify the optimal treatment paradigm for ovarian and bladder clear cell adenocarcinomas.
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics & Gynecology and Women's Health, Jacobi Medical Center and Montefiore Medical Center, Albert Einstein College of Medicine, United States.
authors.forename: Eirwen M
authors.initials: EM
authors.lastname: Miller
authors.affiliation: Department of Pathology, Jacobi Medical Center, Albert Einstein College of Medicine, United States.
authors.forename: Ying
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Division of Urology, Department of Surgery, Jacobi Medical Center, United States.
authors.forename: Ingride
authors.initials: I
authors.lastname: Richardson
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics & Gynecology and Women's Health, Jacobi Medical Center and Montefiore Medical Center, Albert Einstein College of Medicine, United States.
authors.forename: Marina
authors.initials: M
authors.lastname: Frimer
keywords: Bladder cancer; Clear cell adenocarcinoma; Endometriosis; Malignant transformation; Ovarian cancer