title: Can the new CKD-EPI BTP-B2M formula be applied in children?
abstract: Although measuring creatinine to determine kidney function is currently the clinical standard, new markers such as beta-trace protein (BTP) and beta-2-microglobulin (B2M) are being investigated in an effort to measure glomerular filtration rate more accurately. In their recent publication, Inker et al. (Am J Kidney Dis 2015; 67:40-48) explored the use of these two relatively new markers in combination with some commonly available clinical characteristics in a large cohort of adults with chronic kidney disease. Their research led them to develop three formulae using BTP, B2M, and a combination of the two. The combined formula is particularly attractive as it removes all gender bias, which applies to both serum creatinine and cystatin C. Using data from a cohort of 127 pediatric patients from our center, we sought to determine whether these formulae would be equally as effective in children as in adults. Unfortunately, we found that the formulae cannot be applied to the pediatric population.
authors.affiliation: Pediatric Nephrology Division, Department of Pediatrics, , Western University and London Health Sciences Centre, London, ON, Canada. guido.filler@lhsc.on.ca.|Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada. guido.filler@lhsc.on.ca.|Nephrology Division, Department of Medicine, Western University and London Health Sciences Center, London, ON, Canada. guido.filler@lhsc.on.ca.|Pediatric Nephrology Division, Department of Pediatrics, Western University and London Health Sciences Centre, 800 Commissioner Road East, Room B1-436, London, ON, N6A 5 W9, Canada. guido.filler@lhsc.on.ca.
authors.forename: Guido
authors.identifier: 0000-0003-1891-6765
authors.initials: G
authors.lastname: Filler
authors.affiliation: Pediatric Nephrology Division, Department of Pediatrics, , Western University and London Health Sciences Centre, London, ON, Canada.
authors.forename: Ana Catalina
authors.initials: AC
authors.lastname: Alvarez-Elías
authors.affiliation: Division of Nephrology, Department of Medicine, University of North Carolina, Chapel Hill, NC, 27599-7155, USA.
authors.forename: Katherine D
authors.initials: KD
authors.lastname: Westreich
authors.affiliation: Pediatric Nephrology Division, Department of Pediatrics, , Western University and London Health Sciences Centre, London, ON, Canada.|Nephrology Division, Department of Medicine, Western University and London Health Sciences Center, London, ON, Canada.|Department of Medical Biophysics, Western University, London, Canada.
authors.forename: Shih-Han S
authors.initials: SS
authors.lastname: Huang
authors.affiliation: Nephrology Division, Department of Medicine, Western University and London Health Sciences Center, London, ON, Canada.|Department of Medical Biophysics, Western University, London, Canada.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Lindsay
mesh_terms: D000293:Adolescent; D000465:Algorithms; D015415:Biomarkers / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood; D055316:Cystatin C / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000097:blood*; D007677:Kidney Function Tests; D054834:Lipocalins / Q000097:blood*; D008297:Male; D010372:Pediatrics / Q000592:standards*; D012015:Reference Standards; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D001613:beta 2-Microglobulin / Q000097:blood*
chemical_list: D015415:Biomarkers; D055316:Cystatin C; D054834:Lipocalins; D001613:beta 2-Microglobulin; D003404:Creatinine; D019746:Intramolecular Oxidoreductases; C022466:prostaglandin R2 D-isomerase
keywords: Beta-2-microglobulin; Beta-trace protein; Chronic kidney disease; Glomerular filtration rate