title: The Effects of Creatine Monohydrate on Permeability of Coronary Artery Endothelium and Level of Blood Lipoprotein in Diabetic Rats.
abstract: BACKGROUND
  Creatine monohydrate has beneficial effects on serum glucose. This study aimed to investigate the effects of creatine on serum biochemical markers and permeability of coronary arteries among diabetic rats.
  
  
  METHODS
  32 Wistar rats, which weighed 150-200 grams were randomly divided into 4 groups including: group I, control; group II, creatine monohydrate; group III, diabetic rats; and group IV, diabetic rats + creatine. Creatine monohydrate was applied by 400 mg/kg/daily for 5 months. Animals' weights and blood samples were taken before and after the study. Endothelial permeability rate was measured by Evans Blue method. Data were analysed by SPSS 16.
  
  
  RESULTS
  At the end of fifth month, rats' weights in diabetic group under treatment with creatine, compared to those without, increased significantly (p<0.0001). Also, the serum levels of triglyceride (TG), cholesterol, glucose and low density lipoprotein (LDL)- cholesterol decreased significantly among those under treatment with creatine (p<0.05), but high density lipoprotein (HDL)- cholesterol increased significantly (p<0.002). Permeability rate of coronary arteries was reduced significantly in the diabetic group treated by creatine compared to untreated groups, closed to the intact group (p<0.001).
  
  
  CONCLUSIONS
  Results of this study showed that creatine monohydrate caused an improvement of serum biochemical markers associated with diabetes and reduced the permeability rate of coronary arteries among diabetic rats.
authors.affiliation: Medical student, Student Researches Committee, Ilam University of Medical Sciences, Ilam, Iran.
authors.forename: Asghar
authors.initials: A
authors.lastname: Rahmani
authors.affiliation: Department of Epidemiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
authors.forename: Khairollah
authors.initials: K
authors.lastname: Asadollahi
authors.affiliation: Department of Cardiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
authors.forename: Kourosh
authors.initials: K
authors.lastname: Soleimannejad
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Khalighi
authors.affiliation: Department of Cardiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
authors.forename: Yosouf
authors.initials: Y
authors.lastname: Mohsenzadeh
authors.affiliation: Department of Cardiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
authors.forename: Ruhollah
authors.initials: R
authors.lastname: Hemati
authors.affiliation: Medical student, Student Researches Committee, Ilam University of Medical Sciences, Ilam, Iran.
authors.forename: Atefeh
authors.initials: A
authors.lastname: Moradkhani
authors.affiliation: Department of Gastroenterology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran abangah_gh@yahoo.com.
authors.forename: Ghobad
authors.initials: G
authors.lastname: Abangah
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D002199:Capillary Permeability / Q000187:drug effects*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003331:Coronary Vessels / Q000187:drug effects / Q000473:pathology*; D003401:Creatine / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood; D015430:Weight Gain / Q000187:drug effects
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008074:Lipoproteins; D014280:Triglycerides; D003401:Creatine
keywords: Diabetes; creatine monohydrate; endothelial permeability; lipid profile