title: Synthesis of arylated coumarins by Suzuki-Miyaura cross-coupling. Reactions and anti-HIV activity.
abstract: Arylated coumarins were prepared by site-selective Suzuki-Miyaura cross-coupling reaction of the bis(triflate) of 4-methyl-6,7-dihydroxycoumarin. Triarylated coumarins were prepared by Suzuki-Miyaura cross-coupling reactions of 3-bromo-4-methyl-2-oxo-2H-chromene-6,7-diylbis(trifluoromethanesulfonate). The in vitro anti-HIV activity of the products was investigated. Two lead structures with considerable activities were identified.
authors.affiliation: Institute für Chemie, Universitat Rostock, Albert Einstein Str. 3a, 18059 Rostock, Germany; Department of Chemistry, College of Science, University of Mosul, Mosul, Iraq.
authors.forename: Aws M
authors.initials: AM
authors.lastname: Hamdy
authors.affiliation: Institute für Chemie, Universitat Rostock, Albert Einstein Str. 3a, 18059 Rostock, Germany.
authors.forename: Zien
authors.initials: Z
authors.lastname: Khaddour
authors.affiliation: Department of Chemistry, College of Science, University of Basrah, Basrah, Iraq.
authors.forename: Najim A
authors.initials: NA
authors.lastname: Al-Masoudi
authors.affiliation: Institute für Chemie, Universitat Rostock, Albert Einstein Str. 3a, 18059 Rostock, Germany; Amity University, Lucknow Campus, Viraj Khand-5, Gomti Nagar, Lucknow 226010, India.
authors.forename: Qamar
authors.initials: Q
authors.lastname: Rahman
authors.affiliation: Institute für Chemie, Universitat Rostock, Albert Einstein Str. 3a, 18059 Rostock, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Hering-Junghans
authors.affiliation: Institute für Chemie, Universitat Rostock, Albert Einstein Str. 3a, 18059 Rostock, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Villinger
authors.affiliation: Institute für Chemie, Universitat Rostock, Albert Einstein Str. 3a, 18059 Rostock, Germany; Leibniz-Institute für Katalyse an der Universität Rostock e.V., Albert Einstein Str. 29a, 18059 Rostock, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Langer
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D015497:HIV-1 / Q000187:drug effects*; D015498:HIV-2 / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D019380:Anti-HIV Agents; D003374:Coumarins
keywords: Anti-HIV activity; Coumarins; Regioselective synthesis; Suzuki–Miyaura cross-coupling reaction