title: Concussion-Mild Traumatic Brain Injury: Recoverable Injury with Potential for Serious Sequelae.
abstract: Concussion is increasingly recognized as a major public health issue. Most patients will return to baseline and experience full recovery, although a subset experiences persistent symptoms. Newer animal models and imaging studies are beginning to demonstrate that metabolic and neurovascular resolution may actually take longer than symptomatic recovery. Repeat traumatic brain injury within the metabolic window of dysfunction may result in worsened symptoms and prolonged recovery. The true risk for second impact syndrome appears to be small, and development of cerebral edema after a mild impact may be related to genetic risks rather than serial impacts.
authors.affiliation: Department of Neurology, University of California Los Angeles, 710 Westwood Plaza, Suite 1-240, Los Angeles, CA 90095-1769, USA.
authors.forename: Joshua
authors.initials: J
authors.lastname: Kamins
authors.affiliation: Departments of Neurosurgery and Pediatrics, Mattel Children's Hospital-UCLA, University of California Los Angeles, Room 531 Wasserman, 300 Stein Plaza, Los Angeles, CA 90095, USA. Electronic address: cgiza@mednet.ucla.edu.
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Giza
mesh_terms: D001924:Brain Concussion / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D000070642:Brain Injuries, Traumatic / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D003071:Cognition / Q000502:physiology*; D006801:Humans; D009048:Motor Skills / Q000502:physiology*; D012307:Risk Factors; D012720:Severity of Illness Index
keywords: Concussion; Mild TBI; Sequalae of concussion