title: Discordant HIV DNA PCR results among infants diagnosed with HIV infection and initiated on ART: a case series.
abstract: This case series reports three infants diagnosed with HIV-1 infection using DNA polymerase chain reaction (PCR) testing. The three children were initiated on antiretroviral therapy (ART) at ten, four and six months of age. Their serological tests at 18 months of age were negative for HIV-1. The first child was discontinued from ART. The other two children were HIV-negative after 18 months, but were continued on ART. Such seroreversion may be either due to viral suppression or false-positive DNA PCR results. There is a need to develop guidelines to address such discordant cases.
authors.affiliation: 1 National AIDS Research Institute (ICMR), Pune India.
authors.forename: Dhanashree D
authors.initials: DD
authors.lastname: Jagtap
authors.affiliation: 2 Centre for Public Health, School of Health Systems Studies, Tata Institute of Social Sciences, Mumbai, India.
authors.forename: Nilesh C
authors.initials: NC
authors.lastname: Gawde
authors.affiliation: 1 National AIDS Research Institute (ICMR), Pune India.
authors.forename: Suchit V
authors.initials: SV
authors.lastname: Kamble
authors.affiliation: 3 Active ART Services in Health Area (AASHA) ART Center, General Hospital, Bhandara, India.
authors.forename: Ajay P
authors.initials: AP
authors.lastname: Sharma
authors.affiliation: 1 National AIDS Research Institute (ICMR), Pune India.
authors.forename: Ramesh S
authors.initials: RS
authors.lastname: Paranjape
mesh_terms: D042241:Early Diagnosis; D005260:Female; D015658:HIV Infections / Q000175:diagnosis* / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007223:Infant; D008297:Male
keywords: DBS; EID; Early infant diagnosis; HIV-1 DNA PCR; integrated counseling and testing centres; regional research laboratories