Optic nerve head topography and retinal structural changes in eyes with macrodisks: a comparative study with spectral domain optical coherence tomography.
OBJECTIVE
To compare optic nerve head parameters, the thicknesses of the peripapillary retinal nerve fiber layer (pRNFL), the macular retinal nerve fiber layer (mRNFL), the ganglion cell complex (GCC), and the ganglion cell-inner plexiform layer (GCIPL) in macrodisks and normal-sized healthy disks using spectral domain optical coherence tomography.


METHODS
A total of 88 healthy eyes (42 macrodisks and 46 normal-sized disks) were prospectively enrolled in the study. Optic nerve head parameters as well as pRNFL, mRNFL, GCC, and GCIPL thicknesses were measured in all subjects. Optic disk areas (ODAs) >2.70 mm(2) were defined as macrodisks. All spectral domain optical coherence tomography parameters were compared between normal-sized disks and macrodisks.


RESULTS
The mean age of the participants was 49.4±5.7 years in the normal size group and 51.55±6.3 years in the macrodisk group (P=0.65). The average ODAs were 2.23±0.29 mm(2) and 3.30±0.59 mm(2) in the normal size and the macrodisk groups, respectively. ODA (P<0.001), cup area (P<0.001), cup disk area ratio (P<0.001), horizontal cup disk ratio (P<0.001), vertical cup disk ratio (P<0.001), horizontal disk diameter (P<0.001), vertical disk diameter (P<0.001), and cup volume (P<0.001) were significantly higher in the macrodisk group. The inferior mRNFL thickness was significantly lower (P=0.042), and the GCC inferior and GCIPL inferior thicknesses were found to be lower with low significance (P=0.052, P=0.059, respectively) in the macrodisk group. Rim volume (P=0.622), total pRNFL (P=0.201), superior pRNFL (P=0.123), inferior pRNFL (P=0.168), average macular thickness (P=0.162), total mRNFL (P=0.171), superior mRNFL (P=0.356), total GCC (P=0.080), superior GCC (P=0.261), total GCIPL (P=0.214), and superior GCIPL (P=0.515) thicknesses were similar in both groups.


CONCLUSIONS
Optic disk topography and retinal structures show different characteristics in healthy eyes with macrodisks. These disk size-dependent variations suggest that large optic disks may be more susceptible to glaucomatous damage.
Ophthalmology Department, Istanbul Research and Training Hospital, Istanbul, Turkey.
Zeynep Kayaarası
ZK
Öztürker
Ophthalmology Department, Istanbul Research and Training Hospital, Istanbul, Turkey.
Kadir
K
Eltutar
Ophthalmology Department, Istanbul Research and Training Hospital, Istanbul, Turkey.
Belma
B
Karini
Ophthalmology Department, Istanbul Research and Training Hospital, Istanbul, Turkey.
Sezin Özdogan
SÖ
Erkul
Ophthalmology Department, Istanbul Research and Training Hospital, Istanbul, Turkey.
Özen Ayrancı
ÖA
Osmanbaşoğlu
Ophthalmology Department, Istanbul Research and Training Hospital, Istanbul, Turkey.
Pınar
P
Sultan
ganglion cell complex; macrodisk; nerve fiber layer; optic nerve head
Arch Ophthalmol. 1998 Apr;116(4):493-7
9565048
Invest Ophthalmol Vis Sci. 2012 Jul 27;53(8):4990-7
22743319
Invest Ophthalmol Vis Sci. 2003 Feb;44(2):623-37
12556392
Ophthalmology. 2009 Dec;116(12):2305-14.e1-2
19744726
Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1446-52
19834029
Arch Ophthalmol. 1981 Jan;99(1):137-43
7458737
Invest Ophthalmol Vis Sci. 2011 Oct 11;52(11):8094-101
21911590
Clin Ophthalmol. 2011;5:1333-7
22034552
Invest Ophthalmol Vis Sci. 2011 Mar 14;52(3):1412-21
21087959
Prog Retin Eye Res. 2000 Jan;19(1):1-40
10614679
J Opt Soc Am A Opt Image Sci Vis. 2002 Jan;19(1):197-207
11778725
Can J Ophthalmol. 2011 Dec;46(6):543-7
22153644
Am J Ophthalmol. 2005 Jan;139(1):44-55
15652827
Ophthalmology. 1988 Mar;95(3):357-63
3174003
Eur J Ophthalmol. 2012 Jan-Feb;22(1):63-9
22167543
Br J Ophthalmol. 2005 Apr;89(4):489-92
15774930
Invest Ophthalmol Vis Sci. 2000 Jun;41(7):1764-73
10845597
Graefes Arch Clin Exp Ophthalmol. 1992;230(6):552-60
1427140
Ophthalmic Res. 1991;23(2):67-72
1870843
Arch Ophthalmol. 1994 Aug;112(8):1068-76
8053821
Eye (Lond). 2011 Jan;25(1):57-65
20930859
J Glaucoma. 2014 Oct-Nov;23(8):e152-6
24240877
Ophthalmic Surg. 1992 Jul;23(7):469-71
1407944
Arch Ophthalmol. 1991 Oct;109(10):1441-3
1929937
Am J Ophthalmol. 2003 Apr;135(4):504-12
12654368
J Glaucoma. 1999 Dec;8(6):347-52
10604292
Opt Lett. 2002 Aug 15;27(16):1415-7
18026464
Clin Exp Optom. 1999 Sep-Oct;82(5):200-202
12482281
Arch Ophthalmol. 2005 Sep;123(9):1188-97
16157798
Ophthalmology. 2007 Jun;114(6):1046-52
17210181
Int Ophthalmol. 2001;23(4-6):251-7
11944849
Prog Retin Eye Res. 2005 Jan;24(1):39-73
15555526
Ophthalmology. 2012 Jun;119(6):1151-8
22365056
Arch Ophthalmol. 1990 Mar;108(3):393-8
2310342
Invest Ophthalmol Vis Sci. 1992 May;33(6):2012-8
1582806
Ophthalmology. 2003 Jan;110(1):177-89
12511364
Am J Ophthalmol. 2005 Jan;139(1):39-43
15652826
Eye (Lond). 2012 Jan;26(1):133-9
22079964
Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2315-21
18515577
Graefes Arch Clin Exp Ophthalmol. 2011 Jul;249(7):1039-45
21240522
Arch Ophthalmol. 1987 Dec;105(12):1683-5
3689192
Br J Ophthalmol. 2004 Jun;88(6):766-70
15148209
Ophthalmology. 1991 Jan;98(1):60-3
2023734
Arch Ophthalmol. 1989 Jun;107(6):836-9
2730402
Opt Lett. 2003 Nov 1;28(21):2067-9
14587817
Invest Ophthalmol Vis Sci. 1987 Jun;28(6):913-20
3583630
J Glaucoma. 2007 Jan;16(1):1-8
17224742
Ophthalmology. 2005 Jan;112(1):33-9
15629817
Exp Eye Res. 1988 Apr;46(4):559-68
3384014
Invest Ophthalmol Vis Sci. 1988 Jul;29(7):1151-8
3417404