Carbohydrate Nanoparticles for Brain Delivery.
Many brain tumors and neurological diseases can greatly benefit from the use of emerging nanotechnologies based on targeted nanomedicines that are able to noninvasively transport highly potent and specific pharmaceuticals across the blood-brain barrier. Carbohydrates have received considerable interest as materials for drug carriers due to their natural origin and inherent biodegradability and biocompatibility, as well as due to their hydrophilic character and ease of chemical modification combined with low cost and the possibility for large-scale manufacturing. This chapter provides an overview of the latest research involving the use of carbohydrate-based nanoparticles for drug delivery to the central nervous system. After reviewing the challenges posed by delivering drugs into the brain, the current state-of-the-art approaches for delivery of actives across the blood-brain barrier, including invasive and noninvasive strategies, are presented. A particular focus has been placed on chitosan polymers as they are among the most promising carbohydrate nanocarriers for the preparation and testing of chitosan-based nanomedicines that led, in preclinical proof-of-concept studies, to enhanced brain drug levels and increased pharmacodynamics responses after intravenous, nasal, and oral administration. While chitosan nanoparticles are to date among the most studied and most promising carriers, approaches based on other polysaccharides such as dextran, pullulan, and cellulose warrant further research in the attempt to advance the existing technologies for overcoming the blood-brain barrier.
School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom. Electronic address: katerina.lalatsa@port.ac.uk.
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Lalatsa
School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom.
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D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects*; D001927:Brain Diseases / Q000188:drug therapy*; D002241:Carbohydrates / Q000494:pharmacology*; D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage*
D002241:Carbohydrates
Blood–brain barrier; Carbohydrates; Cellulose nanocrystals; Chitosan; Cyclodextrins; Dextran; Hyaluronic acid; Nanoparticles; Nasal; Pullulan