Prophylactic versus symptomatic Ladd procedures for pediatric malrotation.
Intestinal malrotation can lead to volvulus resulting in necrosis, sepsis, and death. For symptomatic patients, treatment includes the Ladd procedure. However, debate remains regarding the timing and need for intervention for asymptomatic infants. We evaluated our experience with Ladd procedures including a clinical practice of prophylactic surgery for asymptomatic patients.



A retrospective review of pediatric patients undergoing the Ladd procedure was performed. Prophylactic Ladd procedures were identified as those occurring before any malrotation-related symptoms. Results were analyzed with student t test, Mann-Whitney U, and chi-squared tests.



From 2011-2014, 42 patients (prophylactic = 19, symptomatic = 23) underwent the Ladd procedure. The median age (IQR, interquartile range) of patients was 9.6 (3.9-18) mo and 18 (2.4-52) mo for prophylactic and symptomatic patients, respectively (P = 0.38). In patients who underwent symptomatic Ladd procedures, nine (39%) had volvulus and one (4.3%) had bowel necrosis at time of surgery. No prophylactic Ladd procedure patients required reoperation, whereas six (26%) symptomatic patients required malrotation-related reoperations (P = 0.02). Median (IQR) days to full enteral feeds were 5.0 d (3.3-6.8) versus 7.4 (5.0-11; P = 0.11), whereas median days to discharge were 8.0 d (6.1-11) versus 11 d (7.5-32) until discharge (P = 0.09) for prophylactic and symptomatic patients, respectively.



Although symptomatic patients represent sicker children, the postoperative complications appear to be higher. For infants with known malrotation, prophylactic operations may be beneficial and should be considered. A larger, prospective study to demonstrate effectiveness and generalizability for prophylactic Ladd procedure is warranted.
Department of Pediatric Surgery, Center for Surgical Trials and Evidence-Based Practice, Houston, Texas.
Sarah E
SE
Covey
Department of Pediatric Surgery, Center for Surgical Trials and Evidence-Based Practice, Houston, Texas; Department of Pediatric Surgery, McGovern Medical School at the University of Texas Health Science Center, Houston, Texas; Department of Pediatric Surgery, Children's Memorial Hermann Hospital, Houston, Texas.
Luke R
LR
Putnam
Department of Pediatric Surgery, Center for Surgical Trials and Evidence-Based Practice, Houston, Texas; Department of Pediatric Surgery, McGovern Medical School at the University of Texas Health Science Center, Houston, Texas; Department of Pediatric Surgery, Children's Memorial Hermann Hospital, Houston, Texas.
Kathryn T
KT
Anderson
Department of Pediatric Surgery, Center for Surgical Trials and Evidence-Based Practice, Houston, Texas; Department of Pediatric Surgery, McGovern Medical School at the University of Texas Health Science Center, Houston, Texas; Department of Pediatric Surgery, Children's Memorial Hermann Hospital, Houston, Texas. Electronic address: kuojen.tsao@uth.tmc.edu.
KuoJen
K
Tsao
D058070:Asymptomatic Diseases; D002675:Child, Preschool; D013505:Digestive System Surgical Procedures / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007415:Intestinal Obstruction / Q000209:etiology / Q000517:prevention & control*; D045822:Intestinal Volvulus / Q000150:complications / Q000601:surgery*; D008297:Male; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology; D012189:Retrospective Studies; D016896:Treatment Outcome
Intestinal malrotation; Ladd procedure; Volvulus