Isolated naratriptan-associated ischemic colitis.
We report a 41-year-old woman who developed histology- and colonoscopy-proven ischemic colitis with the use of naratriptan not exceeding the maximum 2 doses a day and 3 days per week and without a known medical or cardiovascular history. By exclusion of other causes of colonic ischemia, naratriptan was considered the sole causal agent. Discontinuation of naratriptan resulted in a complete clinical recovery. To date, our patient is the youngest known patient to develop ischemic colitis on isolated naratriptan in the setting of no known medical risk factors or predisposing medical condition. Even though triptans are commonly used for the abortive treatment of migraine headaches, such a reported side effect is rare; however, careful assessment and individual patient-based treatment is advised.
Departments of Headache Medicine (Akbar, Nissan, Chaudhry), Gastroenterology (Rangasamy), and Pathology (Mudrovich), Baylor Scott & White Health, Dallas, Texas. Dr. Akbar is now affiliated with the Department of Pediatric Neurology, University of Illinois College of Medicine, Peoria, Illinois.
Asra
A
Akbar
Departments of Headache Medicine (Akbar, Nissan, Chaudhry), Gastroenterology (Rangasamy), and Pathology (Mudrovich), Baylor Scott & White Health, Dallas, Texas. Dr. Akbar is now affiliated with the Department of Pediatric Neurology, University of Illinois College of Medicine, Peoria, Illinois.
George
G
Nissan
Departments of Headache Medicine (Akbar, Nissan, Chaudhry), Gastroenterology (Rangasamy), and Pathology (Mudrovich), Baylor Scott & White Health, Dallas, Texas. Dr. Akbar is now affiliated with the Department of Pediatric Neurology, University of Illinois College of Medicine, Peoria, Illinois.
Priyanka
P
Chaudhry
Departments of Headache Medicine (Akbar, Nissan, Chaudhry), Gastroenterology (Rangasamy), and Pathology (Mudrovich), Baylor Scott & White Health, Dallas, Texas. Dr. Akbar is now affiliated with the Department of Pediatric Neurology, University of Illinois College of Medicine, Peoria, Illinois.
Priya
P
Rangasamy
Departments of Headache Medicine (Akbar, Nissan, Chaudhry), Gastroenterology (Rangasamy), and Pathology (Mudrovich), Baylor Scott & White Health, Dallas, Texas. Dr. Akbar is now affiliated with the Department of Pediatric Neurology, University of Illinois College of Medicine, Peoria, Illinois.
Steven
S
Mudrovich
J Clin Gastroenterol. 2004 Oct;38(9):790-2
15365406
South Med J. 2009 Apr;102(4):405-7
19279546
Gastroenterol Clin Biol. 2002 Nov;26(11):1058-9
12483146
Headache. 2005 Apr;45(4):386-9
15836580
Rev Gastroenterol Peru. 2007 Oct-Dec;27(4):397-401
18257174
Headache. 2005 Nov-Dec;45(10 ):1418-9; author reply 1419-20
16324179
Turk J Gastroenterol. 2010 Mar;21(1):42-4
20533112
Neurology. 2004 Feb 24;62(4):563-8
14981171