Working-for-Food Behaviors: A Preclinical Study in Prader-Willi Mutant Mice.
Abnormal feeding behavior is one of the main symptoms of Prader-Willi syndrome (PWS). By studying a PWS mouse mutant line, which carries a paternally inherited deletion of the small nucleolar RNA 116 (Snord116), we observed significant changes in working-for-food behavioral responses at various timescales. In particular, we report that PWS mutant mice show a significant delay compared to wild-type littermate controls in responding to both hour-scale and seconds-to-minutes-scale time intervals. This timing shift in mutant mice is associated with better performance in the working-for-food task, and results in better decision making in these mutant mice. The results of our study reveal a novel aspect of the organization of feeding behavior, and advance the understanding of the interplay between the metabolic functions and cognitive mechanisms of PWS.
Neuroscience and Brain Technologies Department, Istituto Italiano di Tecnologia, 16163 Genova, Italy.
Glenda
G
Lassi
Neuroscience and Brain Technologies Department, Istituto Italiano di Tecnologia, 16163 Genova, Italy.
Silvia
S
Maggi
Neuroscience and Brain Technologies Department, Istituto Italiano di Tecnologia, 16163 Genova, Italy.
Edoardo
E
Balzani
Neuroscience and Brain Technologies Department, Istituto Italiano di Tecnologia, 16163 Genova, Italy.
Ilaria
I
Cosentini
Neuroscience and Brain Technologies Department, Istituto Italiano di Tecnologia, 16163 Genova, Italy.
Celina
C
Garcia-Garcia
Neuroscience and Brain Technologies Department, Istituto Italiano di Tecnologia, 16163 Genova, Italy valter.tucci@iit.it.
Valter
0000-0002-3796-3826
V
Tucci
D000818:Animals; D003657:Decision Making; D005247:Feeding Behavior; D051379:Mice; D008810:Mice, Inbred C57BL; D011218:Prader-Willi Syndrome / Q000235:genetics / Q000503:physiopathology*; D020537:RNA, Small Nucleolar / Q000235:genetics; D011930:Reaction Time
D020537:RNA, Small Nucleolar; C000609194:SNORD116 RNA, mouse
Prader-Willi; behavioral timing; food anticipatory activity; genomic imprinting
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