G Protein-Coupled Receptors in Myelinating Glia.
The G protein-coupled receptor (GPCR) superfamily represents the largest class of functionally selective drug targets for disease modulation and therapy. GPCRs have been studied in great detail in central nervous system (CNS) neurons, but these important molecules have been relatively understudied in glia. In recent years, however, exciting new roles for GPCRs in glial cell biology have emerged. We focus here on the key roles of GPCRs in a specialized subset of glia, myelinating glia. We highlight recent work firmly establishing GPCRs as regulators of myelinating glial cell development and myelin repair. These advances expand our understanding of myelinating glial cell biology and underscore the utility of targeting GPCRs to promote myelin repair in human disease.
Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Amit
A
Mogha
Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Mitchell
M
D'Rozario
Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: monkk@wustl.edu.
Kelly R
KR
Monk
D000818:Animals; D002490:Central Nervous System / Q000378:metabolism; D015195:Drug Design; D006801:Humans; D058990:Molecular Targeted Therapy; D009186:Myelin Sheath / Q000378:metabolism*; D009457:Neuroglia / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*
D043562:Receptors, G-Protein-Coupled
G protein-coupled receptor (GPCR); Schwann cell; myelination; oligodendrocyte; remyelination
Glia. 2016 Apr;64(4):570-82
26662919
Mol Pharmacol. 2003 Jun;63(6):1256-72
12761335
Cell Rep. 2014 Dec 24;9(6):2018-26
25533341
J Neurosci Res. 1990 Sep;27(1):43-6
2174977
J Peripher Nerv Syst. 2005 Jun;10(2):128-43
15958125
Cell Signal. 2016 Jun;28(6):631-42
26971834
Brain. 2013 Apr;136(Pt 4):1035-47
23518706
Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9023-8
16757564
Nature. 2016 Aug 25;536(7617):464-8
27501152
Nat Rev Drug Discov. 2006 Dec;5(12):993-6
17139284
Development. 2013 Aug;140(15):3167-75
23804499
Cell. 2014 Jan 16;156(1-2):277-90
24439382
Trends Pharmacol Sci. 2012 May;33(5):268-72
22503476
Nat Genet. 1994 Nov;8(3):297-302
7874173
Science. 2009 Jan 30;323(5914):651-4
19179536
Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):11062-7
20534485
Annu Rev Pharmacol Toxicol. 2013;53:127-46
23020293
Nat Rev Neurosci. 2004 Dec;5(12):952-62
15550950
Curr Opin Neurobiol. 2016 Aug;39:93-100
27152449
Science. 2009 Sep 11;325(5946):1402-5
19745155
Am J Hum Genet. 2015 Jun 4;96(6):955-61
26004201
Nat Neurosci. 2010 Mar;13(3):310-8
20098419
EMBO J. 2012 Mar 21;31(6):1364-78
22333914
Glia. 2015 Oct;63(10):1671-93
25782433
Genomics. 2006 Sep;88(3):263-73
16753280
Science. 2016 Jan 22;351(6271):379-84
26798014
J Neurosci. 2016 Jul 27;36(30):7925-35
27466337
Cell Rep. 2015 May 12;11(6):866-74
25937282
Glia. 2015 Aug;63(8):1376-93
25921593
Glia. 2013 Mar;61(3):420-31
23281138
Genes Dev. 2009 Jul 1;23(13):1571-85
19515974
Science. 2004 Apr 30;304(5671):700-3
15044753
Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18174-9
24151333
EMBO J. 2006 Oct 4;25(19):4615-27
16990797
Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5233-8
10220449
Hum Mol Genet. 2014 May 1;23(9):2279-89
24319099
Nat Neurosci. 2009 Nov;12(11):1398-406
19838178
J Neurosci. 2013 Nov 13;33(46):17976-85
24227709
Dev Neurobiol. 2011 Nov;71(11):924-55
21834081
J Neurosci. 2015 Mar 25;35(12):5007-22
25810530
Brain Res. 2016 Jun 15;1641(Pt A):79-91
26498880
Nat Commun. 2015 Jan 21;6:6121
25607655
J Neurosci. 2014 Sep 3;34(36):11929-47
25186741
Neuron. 2015 Feb 18;85(4):669-82
25695267
Glia. 2013 Dec;61(12 ):2009-22
24115248
Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12925-30
21768377
Biomed Res Int. 2013;2013:683405
24024207
Nat Commun. 2016 Apr 04;7:11120
27040771
Dev Dyn. 2008 Nov;237(11):3324-31
18924237
Nat Immunol. 2013 Jun;14(6):554-63
23624557
Hum Mol Genet. 2011 Mar 1;20(5):1000-7
21159798
Nature. 2013 Oct 17;502(7471):327-32
24107995
Neuron. 2015 Feb 18;85(4):755-69
25695270
Annu Rev Physiol. 2012;74:225-43
22054239
Sci Signal. 2014 Aug 12;7(338):ra76
25118328
Nat Med. 2014 Aug;20(8):954-60
24997607
Nature. 2015 Jun 11;522(7555):216-20
25896324
Trends Pharmacol Sci. 2013 Jul;34(7):401-12
23763867
Cell Adh Migr. 2013 Jan-Feb;7(1):111-21
23154401
Neuron. 2014 Feb 5;81(3):588-602
24507193
Glia. 2011 May;59(5):720-33
21322058
J Cell Biol. 2007 Jun 18;177(6):1051-61
17576798
Front Cell Neurosci. 2015 Jan 14;8:462
25642169
J Biol Chem. 2016 Jan 8;291(2):705-18
26620557
Glia. 2011 Dec;59(12):1958-73
21956849
Glia. 2016 Feb;64(2):287-99
26464068
Nat Rev Neurosci. 2016 Sep;17 (9):550-61
27466150
Neuron. 2005 Sep 1;47(5):681-94
16129398
Dev Biol. 2006 Oct 1;298(1):118-31
16875686
Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9529-34
23690594
J Biol Chem. 2011 Mar 25;286(12):10593-604
21209081
Neuron. 2016 Jul 6;91(1):119-32
27292539
FASEB J. 1999 Oct;13(13):1699-710
10506573
Ann Neurol. 2005 Nov;58(5):680-7
16240336
Br J Pharmacol. 2014 Mar;171(5):1195-209
24032637
Pharmacol Rev. 2015;67(2):338-67
25713288
Sci Signal. 2013 Oct 22;6(298):ra93
24150254
Nat Commun. 2016 Mar 10;7:10884
26961174
Neuroscience. 2014 Sep 12;276:29-47
24275321
Development. 2011 Jul;138(13):2673-80
21613327
Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19101-6
24191038
Proc Natl Acad Sci U S A. 2015 May 12;112(19):6194-9
25918380
Nat Commun. 2015 Jan 21;6:6122
25607772
Nat Neurosci. 2014 Dec;17(12):1682-92
25362470
Cell Signal. 2014 Dec;26(12):2614-20
25152366
Neuropharmacology. 2016 Nov;110(Pt B):574-585
27346208
Neurobiol Dis. 2011 Oct;44(1):19-27
21684336
Nature. 2000 May 11;405(6783):187-91
10821275
J Neurosci. 2012 Jan 4;32(1):356-71
22219296
Glia. 2005 May;50(3):258-69
15756692
Brain Res. 2016 Jun 15;1641(Pt A):149-61
26498877
Nat Rev Neurosci. 2005 Sep;6(9):671-82
16136171
Cell Signal. 2007 Jun;19(6):1229-37
17300916