L-Ribose isomerase and mannose-6-phosphate isomerase: properties and applications for L-ribose production.
L-Ribose is a synthetic L-form monosaccharide. It is a building block of many novel nucleotide analog anti-viral drugs. Bio-production of L-ribose relies on a two-step reaction: (i) conversion of L-arabinose to L-ribulose by the catalytic action of L-arabinose isomerase (L-AI) and (ii) conversion of L-ribulose to L-ribose by the catalytic action of L-ribose isomerase (L-RI, EC 5.3.1.B3) or mannose-6-phosphate isomerase (MPI, EC 5.3.1.8, alternately named as phosphomannose isomerase). Between the two enzymes, L-RI is a rare enzyme that was discovered in 1996 by Professor Izumori's group, whereas MPI is an essential enzyme in metabolic pathways in humans and microorganisms. Recent studies have focused on their potentials for industrial production of L-ribose. This review summarizes the applications of L-RI and MPI for L-ribose production.
College of Food Science and Light Industry, Nanjing Tech University, Nanjing, China.|State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing, China.
Zheng
Z
Xu
College of Food Science and Light Industry, Nanjing Tech University, Nanjing, China.|State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing, China.
Yuanyuan
Y
Sha
College of Food Science and Light Industry, Nanjing Tech University, Nanjing, China.|State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing, China.
Chao
C
Liu
College of Food Science and Light Industry, Nanjing Tech University, Nanjing, China.|State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing, China.
Sha
S
Li
College of Food Science and Light Industry, Nanjing Tech University, Nanjing, China.|State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing, China.
Jinfeng
J
Liang
State Key Laboratory of Bio-Organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Jiahai
J
Zhou
College of Food Science and Light Industry, Nanjing Tech University, Nanjing, China. xuh@njtech.edu.cn.|State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing, China. xuh@njtech.edu.cn.|Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing, China. xuh@njtech.edu.cn.
Hong
H
Xu
D019747:Aldose-Ketose Isomerases / Q000378:metabolism*; D006801:Humans; D008359:Mannose-6-Phosphate Isomerase / Q000378:metabolism*; D012266:Ribose / Q000378:metabolism*
D012266:Ribose; D019747:Aldose-Ketose Isomerases; C022546:ribose isomerase; D008359:Mannose-6-Phosphate Isomerase
Hepatitis B virus; L-Ribose; L-Ribose isomerase; L-Sugar; Mannose-6-phosphate isomerase