Pharmaceutical and biomaterial engineering via electrohydrodynamic atomization technologies.
Complex micro- and nano-structures enable crucial developments in the healthcare remit (e.g., pharmaceutical and biomaterial sciences). In recent times, several technologies have been developed and explored to address key healthcare challenges (e.g., advanced chemotherapy, biomedical diagnostics and tissue regeneration). Electrohydrodynamic atomization (EHDA) technologies are rapidly emerging as promising candidates to address these issues. The fundamental principle driving EHDA engineering relates to the action of an electric force (field) on flowing conducting medium (formulation) giving rise to a stable Taylor cone. Through careful optimization of process parameters, material properties and selection, nozzle and needle design, and collection substrate method, complex active micro- and nano-structures are engineered. This short review focuses on key selected recent and established advances in the field of pharmaceutical and biomaterial applications.
Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.
Prina
P
Mehta
Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.
Rita
R
Haj-Ahmad
Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.
Manoochehr
M
Rasekh
Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.
Muhammad S
MS
Arshad
School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, PO1 2DT, UK.
Ashleigh
A
Smith
School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, PO1 2DT, UK.
Susanna M
SM
van der Merwe
State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China.
Xiang
X
Li
College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027, China; Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou 310027, China.
Ming-Wei
MW
Chang
Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK. Electronic address: zahmad@dmu.ac.uk.
Zeeshan
Z
Ahmad
D001672:Biocompatible Materials / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D055664:Electrochemical Techniques / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D057446:Hydrodynamics; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*
D001672:Biocompatible Materials; D004337:Drug Carriers; D004364:Pharmaceutical Preparations