[A glimpse on Staphylococcus aureus translation machinery and its control].
Staphylococcus aureus is a major opportunistic and versatile pathogen. Because the bacteria rapidly evolve multi-resistances towards antibiotics, there is an urgent need to find novel targets and alternative strategies to cure bacterial infections. Here, we provide a brief overview on the knowledge acquired on S. aureus ribosomes, which is one of the major antibiotic targets. We will show that subtle differences exist between the translation at the initiation step of Gram-negative and Gram-positive bacteria although their ribosomes display a remarkable degree of resemblance. In addition, we will illustrate using specific examples the diversity of mechanisms controlling translation initiation in S. aureus that contribute to shape the expression of the virulence factors in a temporal and dynamic manner.
IGBMC (Institute of Genetics and of Molecular and Cellular Biology), Department of Structural Biology and Genomics, Illkirch, F-67404 France; Inserm, U596, Illkirch, F-67400 France; CNRS, UMR7104, Illkirch, F-67400 France; Université Louis Pasteur, Strasbourg, F-67000 France.|Institute of Fundamental Medicine and Biology, Kazan Federal University, Kremlyovskaya St. 18, Kazan 420008, Russia.
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I
Khusainov
Architecture et Réactivité de I'ARN, Université de Strasbourg, CNRS, IBMC, 15 Rue René Descartes, 67084 Strasbourg.
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A
Marenna
IGBMC (Institute of Genetics and of Molecular and Cellular Biology), Department of Structural Biology and Genomics, Illkirch, F-67404 France; Inserm, U596, Illkirch, F-67400 France; CNRS, UMR7104, Illkirch, F-67400 France; Université Louis Pasteur, Strasbourg, F-67000 France.
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Cerciat
Architecture et Réactivité de I'ARN, Université de Strasbourg, CNRS, IBMC, 15 Rue René Descartes, 67084 Strasbourg.
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Fechter
Architecture et Réactivité de I'ARN, Université de Strasbourg, CNRS, IBMC, 15 Rue René Descartes, 67084 Strasbourg.
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Y
Hashem
Architecture et Réactivité de I'ARN, Université de Strasbourg, CNRS, IBMC, 15 Rue René Descartes, 67084 Strasbourg.
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Marzi
Architecture et Réactivité de I'ARN, Université de Strasbourg, CNRS, IBMC, 15 Rue René Descartes, 67084 Strasbourg.|p.romby@ibmc-cnrs.unistra.fr.
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P
Romby
IGBMC (Institute of Genetics and of Molecular and Cellular Biology), Department of Structural Biology and Genomics, Illkirch, F-67404 France; Inserm, U596, Illkirch, F-67400 France; CNRS, UMR7104, Illkirch, F-67400 France; Université Louis Pasteur, Strasbourg, F-67000 France.
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Yusupova
IGBMC (Institute of Genetics and of Molecular and Cellular Biology), Department of Structural Biology and Genomics, Illkirch, F-67404 France; Inserm, U596, Illkirch, F-67400 France; CNRS, UMR7104, Illkirch, F-67400 France; Université Louis Pasteur, Strasbourg, F-67000 France.|Institute of Fundamental Medicine and Biology, Kazan Federal University, Kremlyovskaya St. 18, Kazan 420008, Russia.|marat@igbmc.fr.
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Yusupov
Staphylococcus aureus; post-transcriptional regulation; quorum sensing; regulatory RNAs