Effects of beta-glucan on protection of young and aged rats from renal ischemia and reperfusion injury.
Ischemia-reperfusion injury is one of the leading causes of acute renal failure which is a common clinical event leading to development of chronic kidney disease and a high mortality; especially in elderly people. β-glucans are glucose polymer groups with free-radical scavenger, macrophage activator, and immune defense inducer functions. We designed this study to determine the possible protective effects of β-glucan against renal ischemia-reperfusion injury comparatively in young and aged rats.



Rats were assigned to the following groups: Young and aged sham, young and aged ischemia-reperfusion, young and aged β-glucan, young and aged ischemia-reperfusion+β-glucan. At the end of the experiment, following collection of blood samples, rats were sacrificed and kidneys were removed for histopathological and biochemical examination.



Mean tissue histopathological damage scores of young β-glucan group was lower than that of young ischemia-reperfusion group, and of aged β-glucan group was lower than that of aged ischemia-reperfusion group. Urea and creatinine levels of young and aged of sham group and β-glucan administered groups were all lower than those of ischemia-reperfusion and β-glucan+ischemia-reperfusion groups. Oxidative stress indexes of ischemia-reperfusion groups were increased however ; oxidative stress indexes of β-glucan administered to young and aged rats were lower than those of ischemia-reperfusion groups.



We conclude that β-glucan is effective to protect kidneys from ischemia-reperfusion-induced oxidative damage, especially in young rats (Fig. 6, Ref. 45).
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D058186:Acute Kidney Injury / Q000473:pathology / Q000517:prevention & control; D000367:Age Factors; D000818:Animals; D016166:Free Radical Scavengers / Q000494:pharmacology*; D007511:Ischemia / Q000473:pathology / Q000517:prevention & control*; D007668:Kidney / Q000098:blood supply* / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000473:pathology / Q000517:prevention & control; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000473:pathology / Q000517:prevention & control*; D047071:beta-Glucans / Q000494:pharmacology*
D016166:Free Radical Scavengers; D047071:beta-Glucans
aged rat.; beta-glucan; ischemia and reperfusion; kidney; oxidative damage