COPD, emphysema and the onset of lung cancer. A systematic review.
Chronic Obstructive Pulmonary Disease (COPD) and emphysema have been described as possible risk factors for lung cancer. We aim to assess the relationship between COPD, emphysema and the onset of lung cancer. We have developed a systematic review of the published literature in order to systematically analyze the scientific evidence available on this association, applying predefined inclusion and exclusion criteria. 11 Studies were included. Both COPD and emphysema seem to increase the risk of developing lung cancer, being this risk higher for smokers with heavier tobacco consumption. These results emphasize the need for physicians to perform spirometries in current and former smokers and lung image tests when needed in order to identify COPD and emphysema and thus select patients at higher risk of developing lung cancer.
Pulmonary Department, Hospital Álvaro Cunqueiro, EOXI Vigo; NeumoVigoI+i Research Group, Vigo Biomedical Research Institute (IBIV), Galicia, Spain.
Cecilia
C
Mouronte-Roibás
Pulmonary Department, Hospital Álvaro Cunqueiro, EOXI Vigo; NeumoVigoI+i Research Group, Vigo Biomedical Research Institute (IBIV), Galicia, Spain.
Virginia
V
Leiro-Fernández
Pulmonary Department, Hospital Álvaro Cunqueiro, EOXI Vigo; NeumoVigoI+i Research Group, Vigo Biomedical Research Institute (IBIV), Galicia, Spain.
Alberto
A
Fernández-Villar
Pulmonary Department, Hospital Álvaro Cunqueiro, EOXI Vigo; NeumoVigoI+i Research Group, Vigo Biomedical Research Institute (IBIV), Galicia, Spain.
Maribel
M
Botana-Rial
Pulmonary Department, Hospital Álvaro Cunqueiro, EOXI Vigo; NeumoVigoI+i Research Group, Vigo Biomedical Research Institute (IBIV), Galicia, Spain.
Cristina
C
Ramos-Hernández
Preventive Medicine and Public Health, School of Medicine, University of Santiago de Compostela, San Francisco st s/n Santiago de Compostela, La Coruña, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Spain. Electronic address: alberto.ruano@usc.es.
Alberto
A
Ruano-Ravina
D042241:Early Diagnosis; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000503:physiopathology; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000503:physiopathology / Q000517:prevention & control; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D029424:Pulmonary Disease, Chronic Obstructive / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000503:physiopathology / Q000628:therapy; D011656:Pulmonary Emphysema / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000503:physiopathology / Q000628:therapy; D018570:Risk Assessment; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D016540:Smoking Cessation; D000074606:Smoking Prevention; D013147:Spirometry
COPD; Emphysema; Lung cancer