Role of miRNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer.
Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic miRNAs and downregulated tumour-suppressor miRNAs in this type of cancer. In this review, we provide an overview of the role of miRNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on miRNA activity.
Kelly Cristina da Silva Oliveira, Taíssa Maíra Thomaz Araújo, Camila Inagaki Albuquerque, Gabriela Alcantara Barata, Fernando Augusto Rodrigues Mello Junior, André Salim Khayat, Paulo Pimentel de Assumpção, Danielle Queiroz Calcagno, Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Hospital Universitário João de Barros Barreto, Belém, PA 66073-000, Brazil.
Kelly Cristina
KC
da Silva Oliveira
Kelly Cristina da Silva Oliveira, Taíssa Maíra Thomaz Araújo, Camila Inagaki Albuquerque, Gabriela Alcantara Barata, Fernando Augusto Rodrigues Mello Junior, André Salim Khayat, Paulo Pimentel de Assumpção, Danielle Queiroz Calcagno, Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Hospital Universitário João de Barros Barreto, Belém, PA 66073-000, Brazil.
Taíssa Maíra
TM
Thomaz Araújo
Kelly Cristina da Silva Oliveira, Taíssa Maíra Thomaz Araújo, Camila Inagaki Albuquerque, Gabriela Alcantara Barata, Fernando Augusto Rodrigues Mello Junior, André Salim Khayat, Paulo Pimentel de Assumpção, Danielle Queiroz Calcagno, Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Hospital Universitário João de Barros Barreto, Belém, PA 66073-000, Brazil.
Camila Inagaki
CI
Albuquerque
Kelly Cristina da Silva Oliveira, Taíssa Maíra Thomaz Araújo, Camila Inagaki Albuquerque, Gabriela Alcantara Barata, Fernando Augusto Rodrigues Mello Junior, André Salim Khayat, Paulo Pimentel de Assumpção, Danielle Queiroz Calcagno, Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Hospital Universitário João de Barros Barreto, Belém, PA 66073-000, Brazil.
Gabriela Alcantara
GA
Barata
Kelly Cristina da Silva Oliveira, Taíssa Maíra Thomaz Araújo, Camila Inagaki Albuquerque, Gabriela Alcantara Barata, Fernando Augusto Rodrigues Mello Junior, André Salim Khayat, Paulo Pimentel de Assumpção, Danielle Queiroz Calcagno, Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Hospital Universitário João de Barros Barreto, Belém, PA 66073-000, Brazil.
Carolina Oliveira
CO
Gigek
Kelly Cristina da Silva Oliveira, Taíssa Maíra Thomaz Araújo, Camila Inagaki Albuquerque, Gabriela Alcantara Barata, Fernando Augusto Rodrigues Mello Junior, André Salim Khayat, Paulo Pimentel de Assumpção, Danielle Queiroz Calcagno, Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Hospital Universitário João de Barros Barreto, Belém, PA 66073-000, Brazil.
Mariana Ferreira
MF
Leal
Kelly Cristina da Silva Oliveira, Taíssa Maíra Thomaz Araújo, Camila Inagaki Albuquerque, Gabriela Alcantara Barata, Fernando Augusto Rodrigues Mello Junior, André Salim Khayat, Paulo Pimentel de Assumpção, Danielle Queiroz Calcagno, Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Hospital Universitário João de Barros Barreto, Belém, PA 66073-000, Brazil.
Fernanda
F
Wisnieski
Kelly Cristina da Silva Oliveira, Taíssa Maíra Thomaz Araújo, Camila Inagaki Albuquerque, Gabriela Alcantara Barata, Fernando Augusto Rodrigues Mello Junior, André Salim Khayat, Paulo Pimentel de Assumpção, Danielle Queiroz Calcagno, Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Hospital Universitário João de Barros Barreto, Belém, PA 66073-000, Brazil.
Fernando Augusto
FA
Rodrigues Mello Junior
Kelly Cristina da Silva Oliveira, Taíssa Maíra Thomaz Araújo, Camila Inagaki Albuquerque, Gabriela Alcantara Barata, Fernando Augusto Rodrigues Mello Junior, André Salim Khayat, Paulo Pimentel de Assumpção, Danielle Queiroz Calcagno, Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Hospital Universitário João de Barros Barreto, Belém, PA 66073-000, Brazil.
André Salim
AS
Khayat
Kelly Cristina da Silva Oliveira, Taíssa Maíra Thomaz Araújo, Camila Inagaki Albuquerque, Gabriela Alcantara Barata, Fernando Augusto Rodrigues Mello Junior, André Salim Khayat, Paulo Pimentel de Assumpção, Danielle Queiroz Calcagno, Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Hospital Universitário João de Barros Barreto, Belém, PA 66073-000, Brazil.
Paulo Pimentel
PP
de Assumpção
Kelly Cristina da Silva Oliveira, Taíssa Maíra Thomaz Araújo, Camila Inagaki Albuquerque, Gabriela Alcantara Barata, Fernando Augusto Rodrigues Mello Junior, André Salim Khayat, Paulo Pimentel de Assumpção, Danielle Queiroz Calcagno, Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Hospital Universitário João de Barros Barreto, Belém, PA 66073-000, Brazil.
Rommel Mário
RM
Rodriguez Burbano
Kelly Cristina da Silva Oliveira, Taíssa Maíra Thomaz Araújo, Camila Inagaki Albuquerque, Gabriela Alcantara Barata, Fernando Augusto Rodrigues Mello Junior, André Salim Khayat, Paulo Pimentel de Assumpção, Danielle Queiroz Calcagno, Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Hospital Universitário João de Barros Barreto, Belém, PA 66073-000, Brazil.
Marília Cardoso
MC
Smith
Kelly Cristina da Silva Oliveira, Taíssa Maíra Thomaz Araújo, Camila Inagaki Albuquerque, Gabriela Alcantara Barata, Fernando Augusto Rodrigues Mello Junior, André Salim Khayat, Paulo Pimentel de Assumpção, Danielle Queiroz Calcagno, Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Hospital Universitário João de Barros Barreto, Belém, PA 66073-000, Brazil.
Danielle Queiroz
DQ
Calcagno
D014408:Biomarkers, Tumor / Q000378:metabolism*; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism* / Q000627:therapeutic use*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D012333:RNA, Messenger / Q000378:metabolism; D013274:Stomach Neoplasms / Q000235:genetics* / Q000378:metabolism*
D014408:Biomarkers, Tumor; D035683:MicroRNAs; D012333:RNA, Messenger
Diagnostic biomarkers; Epigenetic; Gastric cancer; Prognostic biomarkers; miRNAs
Med Oncol. 2012 Jun;29(2):856-63
21264532
J Cancer Res Clin Oncol. 2012 Jun;138(6):939-45
22350505
Nat Cell Biol. 2011 Apr;13(4):423-33
21423178
Mol Cell. 2011 Sep 16;43(6):892-903
21925378
Cancer Gene Ther. 2008 Jun;15(6):341-55
18369380
Oncotarget. 2014 Aug 15;5(15):6178-90
25115392
PLoS One. 2013 Apr 17;8(4):e61250
23613822
Biomaterials. 2013 Sep;34(29):7191-203
23806972
Int J Cancer. 2011 Dec 1;129(11):2611-20
21225631
PLoS One. 2014 Apr 23;9(4):e95249
24760009
Oncogene. 2015 May 14;34(20):2556-65
25043310
FEBS Lett. 2013 Sep 17;587(18):3069-75
23932924
FEBS J. 2014 Oct;281(20):4718-30
25156775
DNA Cell Biol. 2012 Jul;31(7):1290-5
22455393
Oncotarget. 2016 Mar 1;7(9):10037-50
26840256
Mol Med Rep. 2012 Jun;5(6):1514-20
22406928
Int J Mol Sci. 2013 Aug 06;14(8):16226-39
23924943
PLoS One. 2012;7(3):e33919
22470493
Carcinogenesis. 2011 May;32(5):713-22
21349817
FEBS Lett. 2012 Mar 23;586(6):722-8
22321642
Clin Cancer Res. 2014 Feb 15;20(4):878-89
24352645
Cancer Lett. 2014 Jan 1;342(1):27-35
23981575
J Gastroenterol Hepatol. 2009 Apr;24(4):652-7
19175831
Cell Death Dis. 2014 Mar 27;5:e1144
24675462
Mol Carcinog. 2013 Aug;52(8):634-46
22431000
Mol Immunol. 2013 Nov;56(1-2):98-103
23688438
PLoS One. 2010 Oct 08;5(10):e13205
20949028
Pathol Oncol Res. 2014 Jan;20(1):93-8
23821457
Nucleic Acids Res. 2009 Apr;37(5):1672-81
19153141
Cancer. 2010 Jan 1;116(1):41-9
19890957
Bioinformation. 2014 Sep 30;10(9):602-5
25352731
J Mol Diagn. 2013 Sep;15(5):661-9
23806809
Cancer Lett. 2009 Nov 28;285(2):116-26
19464788
Med Oncol. 2012 Jun;29(2):886-92
21347720
Med Oncol. 2013 Mar;30(1):452
23307259
BMC Med Genomics. 2011 Nov 23;4:79
22112324
Br J Cancer. 2010 Mar 30;102(7):1174-9
20234369
Int J Cancer. 2011 Dec 1;129(11):2600-10
21960261
Mol Med Rep. 2012 Sep;6(3):501-6
22711166
PLoS One. 2012;7(7):e41629
22860003
Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5003-8
21383194
PLoS One. 2011;6(8):e23271
21876743
PLoS Genet. 2010 Mar 12;6(3):e1000879
20300657
Asian Pac J Cancer Prev. 2013;14 (2):835-40
23621248
Oncogene. 2014 Jan 9;33(2):193-202
23246964
Acta Pathol Microbiol Scand. 1965;64:31-49
14320675
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2014 Apr;36(2):214-7
24791805
Tumour Biol. 2013 Aug;34(4):2127-33
23504555
Epigenomics. 2012 Jun;4(3):279-94
22690664
Nat Rev Mol Cell Biol. 2005 May;6(5):376-85
15852042
Med Sci Monit. 2014 Nov 16;20:2318-26
25399405
Biomed Rep. 2013 Nov;1(6):907-912
24649051
J Infect Dis. 2009 Sep 15;200(6):916-25
19650740
Carcinogenesis. 2010 Jan;31(1):27-36
19752007
Tumour Biol. 2013 Dec;34(6):3705-12
23873106
Asian Pac J Cancer Prev. 2013;14(5):2839-43
23803041
Lancet Oncol. 2010 Feb;11(2):136-46
20022810
Nature. 2004 Sep 16;431(7006):350-5
15372042
Paediatr Perinat Epidemiol. 2008 Sep;22(5):486-96
18782255
Epigenetics. 2014 Jul;9(7):1018-30
24785261
Tumour Biol. 2015 Dec;36(12):9909-18
26168960
Mol Cell Biochem. 2014 Jan;385(1-2):207-13
24078004
J Cell Sci. 2013 Sep 15;126(Pt 18):4220-9
23868977
FEBS Lett. 2014 Feb 14;588(4):538-44
24374340
FEBS Lett. 2014 Feb 14;588(4):600-7
24440352
Med Sci Monit. 2015 Sep 13;21:2718-25
26364844
Mol Carcinog. 2014 Mar;53(3):219-29
23065816
Clin Cancer Res. 2011 Dec 15;17 (24):7574-83
21994419
Lab Invest. 2008 Dec;88(12):1358-66
18794849
IUBMB Life. 2012 Jul;64(7):628-35
22539488
J Biol Chem. 2013 Jan 4;288(1):608-18
23166327
Int J Cancer. 2010 Dec 1;127(11):2520-9
20162574
Cancer Lett. 2009 Jan 18;273(2):233-42
18789835
Cancer Sci. 2014 Feb;105(2):236-43
24283384
Int J Oncol. 2010 May;36(5):1089-95
20372781
Oncology. 2009;77(1):12-21
19439999
J Cancer Res Clin Oncol. 2012 May;138(5):763-74
22270966
PLoS One. 2014 Mar 19;9(3):e92300
24647245
J Exp Clin Cancer Res. 2011 May 13;30:55
21569481
Oncol Rep. 2012 Jun;27(6):1960-6
22426647
Acta Biochim Biophys Sin (Shanghai). 2013 Nov;45(11):963-72
24108762
PLoS One. 2014 Nov 18;9(11):e113401
25406082
Nature. 2008 Sep 4;455(7209):58-63
18668040
Dig Dis Sci. 2010 Aug;55(8):2288-93
19834808
Nucleic Acids Res. 2011 Sep 1;39(16):7223-33
21609964
Br J Cancer. 2014 Apr 29;110(9):2291-9
24595006
J Biomed Res. 2010 May;24(3):187-97
23554630
EMBO Mol Med. 2012 Mar;4(3):143-59
22351564
Clin Chim Acta. 2009 Feb;400(1-2):97-102
18996365
Cell Physiol Biochem. 2015;37(3):1010-7
26394032
Hum Mol Genet. 2007 Apr 15;16 Spec No 1:R50-9
17613547
Mol Pharmacol. 2014 Nov;86(5):536-47
25159093
Mol Carcinog. 2013 Nov;52 Suppl 1:E39-51
23001871
Oncol Rep. 2012 Apr;27(4):1019-26
22267008
Nature. 2008 Sep 4;455(7209):64-71
18668037
J Surg Oncol. 2013 Apr;107(5):505-10
22996433
Bioinformation. 2014 May 20;10(5):246-50
24966529
Biochem Biophys Res Commun. 2010 Apr 16;394(4):1047-52
20331975
Tumour Biol. 2014 Jul;35(7):6373-81
24668547
Eur J Cancer. 2011 Mar;47(5):784-91
21112772
Nat Rev Clin Oncol. 2013 Nov;10(11):643-55
24061039
Am J Transl Res. 2011 Feb;3(2):209-18
21416062
J Pathol. 2010 Nov;222(3):310-9
20726036
Mol Biol Rep. 2014 Feb;41(2):1075-80
24379078
Mol Cancer. 2012 Sep 20;11:71
22992343
Oncotarget. 2016 Jan 26;7(4):4817-28
26716895
World J Gastroenterol. 2011 Aug 21;17(31):3645-51
21987613
BMC Cancer. 2013 Jun 14;13:290
23768087
Helicobacter. 2010 Dec;15(6):524-31
21073609
Clin Exp Med. 2015 Nov;15(4):469-75
25398664
World J Gastroenterol. 2010 Jul 28;16(28):3578-83
20653068
Mol Carcinog. 2012 Oct;51 Suppl 1:E21-31
21976437
Med Oncol. 2014 Mar;31(3):879
24515776
Hum Genet. 2013 Jun;132(6):641-8
23430453
Br J Cancer. 2012 Feb 14;106(4):740-7
22262318
Nature. 2005 Dec 1;438(7068):685-9
16258535
World J Gastroenterol. 2010 Jul 14;16(26):3325-9
20614490
Br J Cancer. 2014 Mar 4;110(5):1199-210
24473397
Cell. 2009 Jun 12;137(6):1005-17
19524505
Oncol Rep. 2012 Feb;27(2):559-66
22020746
Eur J Cancer. 2014 May;50(7):1330-44
24650579
Dig Dis Sci. 2014 Apr;59(4):716-23
24248419
Mol Cancer Res. 2011 Jul;9(7):824-33
21628394
Mol Cancer. 2010 Jan 26;9:16
20102618
Ann Surg Oncol. 2012 Jul;19 Suppl 3:S656-64
22311119
Int J Cancer. 2009 Dec 1;125(11):2737-43
19521961
Zhonghua Zhong Liu Za Zhi. 2010 Apr;32(4):249-52
20510072
Cancer Lett. 2012 Mar 28;316(2):196-203
22169097
Biochem Biophys Res Commun. 2013 May 10;434(3):688-94
23603256
Oncol Lett. 2013 Sep;6(3):631-641
24137382
Clin Cancer Res. 2013 Oct 15;19(20):5602-12
23995857
Med Oncol. 2012 Sep;29(3):1723-32
22108846
Cancer Res. 2006 Feb 1;66(3):1277-81
16452179
Methods Mol Biol. 2015;1238:79-101
25421656
Cancer Sci. 2010 Oct;101(10):2241-7
20666778
Tumour Biol. 2015 Sep;36(10 ):7831-40
25944166
Int J Mol Sci. 2013 Jul 08;14(7):14171-84
23880861
Pathol Int. 2014 Jul;64(7):309-14
25047501
Int J Mol Sci. 2014 Mar 05;15(3):4031-48
24603541
Anal Cell Pathol (Amst). 2012;35(4):285-95
22596182
J Cell Mol Med. 2011 Sep;15(9):1887-95
21029372
Gastroenterol Res Pract. 2012;2012:640168
22792096
Oncol Rep. 2011 Dec;26(6):1431-9
21874264
J Cancer Res Clin Oncol. 2016 Jun;142(6):1201-12
26955820
Cell Biochem Funct. 2012 Jul;30(5):411-8
22374783
Future Oncol. 2013 Mar;9(3):387-402
23469974
World J Gastroenterol. 2013;19(43):7758-65
24616567
Anticancer Res. 2013 Jan;33(1):271-6
23267156
Dig Dis Sci. 2011 Apr;56(4):1131-7
20721625
Gastric Cancer. 2015 Apr;18(2):271-9
24626859
Clin Cancer Res. 2011 Jul 1;17(13):4277-84
21632853
Mol Carcinog. 2016 Apr;55(4):376-86
25663388
World J Gastroenterol. 2013 Feb 28;19(8):1182-92
23482412
Mol Aspects Med. 2013 Jul-Aug;34(4):863-74
22771542
PLoS One. 2013 Sep 09;8(9):e73683
24040025
Cell Death Dis. 2012 Nov 15;3:e423
23152059
Oncol Rep. 2015 May;33(5):2529-36
25760688
Dig Liver Dis. 2012 Jul;44(7):589-96
22464652
Scand J Gastroenterol. 2011 Jan;46(1):53-9
20809749
Epigenetics. 2011 Oct 1;6(10):1189-97
21931274
BMC Cancer. 2010 Jul 12;10 :367
20618998
J Cancer Res Clin Oncol. 2014 Sep;140(9):1451-6
24659367
PLoS One. 2013;8(1):e55719
23383271
J Exp Clin Cancer Res. 2009 Jun 16;28:82
19531230
Asian Pac J Cancer Prev. 2012;13(5):2263-7
22901205
Cell Cycle. 2007 May 2;6(9):1001-5
17457051
Clin Transl Oncol. 2015 Jan;17(1):34-40
24981590
Cancer Lett. 2013 Jul 10;335(1):219-24
23435376
Bull Cancer. 2015 Dec;102(12):973-8
26597478
Dig Dis Sci. 2014 Jan;59(1):24-30
24114043
Cancer Cell. 2008 Mar;13(3):272-86
18328430
Cancer Lett. 2013 Oct 28;340(1):72-81
23851184
Oncol Rep. 2012 Jun;27(6):1759-64
22407237
Oncogene. 2009 Jul 30;28(30):2738-44
19503096
J Cancer Res Clin Oncol. 2012 Apr;138(4):611-9
22212233