Glomerular Glucocorticoid Receptors Expression and Clinicopathological Types of Childhood Nephrotic Syndrome.
Glucocorticoids are primary therapy of idiopathic nephrotic syndrome (INS). However, not all children respond to steroid therapy. We assessed glomerular glucocorticoid receptor expression in fifty-one children with INS and its relation to response to steroid therapy and to histopathological type. Clinical, laboratory and glomerular expression of glucocorticoid receptors were compared between groups with different steroid response. Glomerular glucocorticoid expression was slightly higher in controls than in minimal change early responders, which in turn was significantly higher than in minimal change late responders. There was significantly lower glomerular glucocorticoid receptor expression in steroid-resistance compared to early responders, late responders and controls. Glomerular glucocorticoid expression was significantly higher in all minimal change disease (MCD) compared to focal segmental glomerulosclerosis. In INS, response to glucocorticoid is dependent on glomerular expression of receptors and peripheral expression. Evaluation of glomerular glucocorticoid receptor expression at time of diagnosis of NS can predict response to steroid therapy.
a Pathology Department , Assiut University Faculty of Medicine , Assiut , Egypt.
Yasser
Y
Gamal
b Pediatric Department , Assiut University Faculty of Medicine , Assiut , Egypt.
Ahlam
A
Badawy
c Pediatric Department , Minia University Faculty of Medicine , El Minia , Egypt.
Salwa
S
Swelam
b Pediatric Department , Assiut University Faculty of Medicine , Assiut , Egypt.
Mostafa S K
MS
Tawfeek
b Pediatric Department , Assiut University Faculty of Medicine , Assiut , Egypt.
Eman Fathalla
EF
Gad
D000293:Adolescent; D001706:Biopsy; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000175:diagnosis / Q000378:metabolism; D005938:Glucocorticoids / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000378:metabolism; D007678:Kidney Glomerulus / Q000378:metabolism*; D008297:Male; D009402:Nephrosis, Lipoid / Q000175:diagnosis / Q000378:metabolism; D009404:Nephrotic Syndrome / Q000175:diagnosis / Q000378:metabolism*; D011446:Prospective Studies; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D013256:Steroids / Q000627:therapeutic use
D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid; D013256:Steroids
Glomerular glucocorticoid receptors; childhood nephrotic syndrome; focal segmental glomerulosclerosis; glucocorticoid therapy; minimal change disease