Corneal stromal demarcation line after collagen cross-linking in corneal ectatic diseases: a review of the literature.
Collagen cross-linking (CXL) is a relatively new conservative approach for progressive corneal ectasia, which is able to strengthen corneal tissue reforming new covalent bonds. Subjective and objective results following this method seem to be promising. In recent years, newer CXL protocols have been developed to perform more effective and less invasive procedures. The increasing diffusion of CXL in the corneal ectatic disease has increased the need to have actual indices regarding the efficacy of the treatment. Evaluation of demarcation line (DL), a transition zone between the cross-linked anterior corneal stroma and the untreated posterior corneal stroma, is considered a measurement of the depth of CXL treatment into the stroma. Some evidence in the literature emphasize that DL could be a measure of effectiveness of the CXL. On the contrary, some authors believe that the "the deeper, the better" principle is rather a simplistic approach for interpreting the clinical importance of the corneal stromal DL.
Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Leopoldo
L
Spadea
Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Emanuele
E
Tonti
Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Enzo Maria
EM
Vingolo
corneal cross-linking; demarcation line; keratoconus; ultraviolet A
J Optom. 2014 Jul-Sep;7(3):113-24
25000866
Ophthalmologica. 2008;222(5):334-7
18628636
Am J Ophthalmol. 2015 Aug;160(2):243-9
26008626
Cornea. 2006 Oct;25(9):1057-9
17133053
Open Ophthalmol J. 2011 Feb 11;5:11-3
21399769
J Refract Surg. 2014 Nov;30(11):746-53
25375847
Am J Ophthalmol. 2014 Jan;157(1):110-115.e1
24200235
Cornea. 2004 Jan;23(1):43-9
14701957
J Ophthalmol. 2011;2011:608041
21837270
Surv Ophthalmol. 2015 Nov-Dec;60(6):509-23
25980780
J Cataract Refract Surg. 2008 May;34(5):796-801
18471635
J Refract Surg. 2016 Apr;32(4):218-22
27070227
Clin Ophthalmol. 2013;7:2019-30
24143069
Graefes Arch Clin Exp Ophthalmol. 2015 Feb;253(2):277-86
25363654
Cornea. 2009 Jan;28(1):62-7
19092408
Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5030-3
20463316
Am J Ophthalmol. 2014 Oct;158(4):671-675.e1
25034113
Cornea. 2009 Aug;28(7):719-23
19574920
Clin Ophthalmol. 2012;6:1793-800
23152658
Invest Ophthalmol Vis Sci. 2012 Apr 30;53(4):2360-7
22427580
J Cataract Refract Surg. 2016 May;42(5):804
27255259
Transl Vis Sci Technol. 2013 Nov;2(7):6
24349884
J Refract Surg. 2015 Jan;31(1):36-40
25599541
Ophthalmology. 2006 Feb;113(2):184-90
16368147
Clin Ophthalmol. 2012;6:1785-92
23152657
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1974;190(4):293-308
4547927
J Ophthalmol. 2014;2014:981893
25485145
Clin Ophthalmol. 2012;6:1801-13
23152659
Clin Exp Ophthalmol. 2007 Aug;35(6):580-2
17760642
Acta Ophthalmol. 2016 Nov;94(7):e600-e606
27040458
J Cataract Refract Surg. 2015 Apr;41(4):842-72
25840308
J Refract Surg. 2010 Sep;26(9):638-45
19928694
Exp Eye Res. 1998 Jan;66(1):97-103
9533835
Acta Ophthalmol. 2014 Feb;92(1):e30-4
23848196
Arq Bras Oftalmol. 2011 Sep-Oct;74(5):348-51
22183995
J Refract Surg. 2013 Dec;29(12):846-8
24168788
Eye (Lond). 2014 Oct;28(10):1179-83
25060847
J Refract Surg. 2011 May;27(5):323-31
21117539
Am J Ophthalmol. 2003 May;135(5):620-7
12719068
J Cataract Refract Surg. 2015 Mar;41(3):527-32
25648281
Invest Ophthalmol Vis Sci. 1998 Jun;39(7):1117-24
9620070
J Cataract Refract Surg. 2007 Sep;33(9):1530-8
17720066
Cornea. 2015 Feb;34(2):199-203
25514703
J Cataract Refract Surg. 2013 Jun;39(6):968
23688900
J Refract Surg. 2016 Jan;32(1):47-50
26812714
J Refract Surg. 1999 Nov-Dec;15(6):711-3
10590015
Invest Ophthalmol Vis Sci. 2012 May 04;53(6):2620-9
22447859
J Cataract Refract Surg. 2012 Feb;38(2):283-91
22104644
Am J Ophthalmol. 2009 Dec;148(6):844-51.e2
19781685
J Cataract Refract Surg. 2015 Nov;41(11):2546-51
26703505
Invest Ophthalmol Vis Sci. 1978 Jan;17(1):63-5
621128
Eye Vis (Lond). 2015 Sep 07;2:15
26605368
Am J Ophthalmol. 2012 May;153(5):982-993.e3
22265143
J Refract Surg. 2008 Sep;24(7):S720-5
18811118
Exp Eye Res. 1980 Oct;31(4):435-41
7449878
J Refract Surg. 2012 Jul;28(7):475-81
22767165
Int Ophthalmol. 2017 Feb;37(1):279-283
27177621
Am J Ophthalmol. 2010 Apr;149(4):585-93
20138607
J Cataract Refract Surg. 2014 May;40(5):736-40
24630796
Clin Ophthalmol. 2012;6:1125-30
22888210
Invest Ophthalmol Vis Sci. 2014 Apr 17;55(4):2526-33
24667859
J Refract Surg. 2010 May;26(5):375-7
20128533
Invest Ophthalmol Vis Sci. 2014 Mar 13;55(3):1549-54
24508795
Cornea. 2007 May;26(4):390-7
17457184
Biomed Res Int. 2015;2015:795738
26075261
Ocul Surf. 2013 Apr;11(2):65-74
23583042