Tocotrienol and Its Role in Chronic Diseases.
Tocotrienol is a member of vitamin E family and is well-known for its antioxidant and anti-inflammatory properties. It is also a suppressor of mevalonate pathway responsible for cholesterol and prenylated protein synthesis. This review aimed to discuss the health beneficial effects of tocotrienol, specifically in preventing or treating hyperlipidaemia, diabetes mellitus, osteoporosis and cancer with respect to these properties. Evidence from in vitro, in vivo and human studies has been examined. It is revealed that tocotrienol shows promising effects in preventing or treating the health conditions previously mentioned in in vivo and in vitro models. In some cases, alpha-tocopherol attenuates the biological activity of tocotrienol. Except for its cholesterol-lowering effects, data on the health-promoting effects of tocotrienol in human are limited. As a conclusion, the encouraging results on the health beneficial effects of tocotrienol should motivate researchers to explore its potential use in human.
Department of Pharmacology, Universiti Kebangsaan Malaysia Medical Centre, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000, Kuala Lumpur, Malaysia.
Kok-Yong
KY
Chin
Biomedical Science Programme, School of Diagnostic and Applied Health Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Abdul Aziz, 50300, Kuala Lumpur, Malaysia.
Kok-Lun
KL
Pang
Department of Pharmacology, Universiti Kebangsaan Malaysia Medical Centre, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000, Kuala Lumpur, Malaysia. imasoel@ppukm.ukm.edu.my.
Ima-Nirwana
IN
Soelaiman
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000924:Anticholesteremic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D002908:Chronic Disease; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology; D010024:Osteoporosis / Q000188:drug therapy; D024508:Tocotrienols / Q000494:pharmacology / Q000627:therapeutic use*
D000893:Anti-Inflammatory Agents; D000924:Anticholesteremic Agents; D000975:Antioxidants; D007004:Hypoglycemic Agents; D024508:Tocotrienols
Bone; Cancer; Cholesterol; Diabetes; Glucose; Osteoporosis; Tocopherol; Tocotrienol; Vitamin E