Impact of Marital Status on Tumor Stage at Diagnosis and on Survival in Male Breast Cancer.
The effect of marital status (MS) on survival varies according to cancer type and gender. There has been no report on the impact of MS on survival in male breast cancer (MBC). This study aims to determine the influence of MS on tumor stage at diagnosis and survival in MBC. Men with MBC ≥18 years of age in the SEER database from 1990 to 2011 were included in the study. MS was classified as married and unmarried (including single, divorced, separated, widowed). Kaplan-Meier method was used to estimate the 5-year cancer-specific survival. Multivariate regression analyses were done to determine the effect of MS on presence of Stage IV disease at diagnosis and on cancer-specific mortality. The study included 3,761 men; 2,647 (70.4%) were married. Unmarried men were more often diagnosed with Stage IV MBC compared with married (10.7% vs. 5.5%, p < .001). Unmarried men (compared with married) were significantly less likely to undergo surgery (92.4% vs. 96.7%, p < .001). Overall unmarried males with Stages II, III, and IV MBC have significantly worse 5-year cancer-specific survival compared with married. On multivariate analysis, being unmarried was associated with increased hazard of death (HR = 1.43, p < .001) and increased likelihood of Stage IV disease at diagnosis ( OR = 1.96, p < .001). Unmarried males with breast cancer are at greater risk for Stage IV disease at diagnosis and poorer outcomes compared with married males.
1 McLaren Flint, Flint, MI, USA.|2 Michigan State University, East Lasing, MI, USA.
Orimisan Samuel
OS
Adekolujo
1 McLaren Flint, Flint, MI, USA.|2 Michigan State University, East Lasing, MI, USA.
Shourya
S
Tadisina
1 McLaren Flint, Flint, MI, USA.|2 Michigan State University, East Lasing, MI, USA.
Ujwala
U
Koduru
1 McLaren Flint, Flint, MI, USA.
Jill
J
Gernand
1 McLaren Flint, Flint, MI, USA.|2 Michigan State University, East Lasing, MI, USA.
Susan Jane
SJ
Smith
1 McLaren Flint, Flint, MI, USA.|2 Michigan State University, East Lasing, MI, USA.
Radhika Ramani
RR
Kakarala
D000328:Adult; D000368:Aged; D018567:Breast Neoplasms, Male / Q000401:mortality* / Q000473:pathology*; D006801:Humans; D008297:Male; D017533:Marital Status; D008875:Middle Aged; D009367:Neoplasm Staging; D018426:SEER Program; D016019:Survival Analysis; D014481:United States / Q000453:epidemiology
male breast cancer; marital status; survival
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