Herb-Drug Interaction: Effects of Relinqing® Granule on the Pharmacokinetics of Ciprofloxacin, Sulfamethoxazole, and Trimethoprim in Rats.
Relinqing granule (RLQ) is the best-selling Chinese patent drug for treatment of urinary system diseases. In this study, the effects of RLQ on the pharmacokinetics of ciprofloxacin, sulfamethoxazole, and trimethoprim in SD rats were investigated. Rats were randomly divided into control group 1, control group 2, RLQ group 1, and RLQ group 2. RLQ group 1 and RLQ group 2 were treated orally with RLQ for 7 days, and rats were treated with the same volume of water in control group 1 and control group 2. Then, RLQ group 1 and control group 1 were given intragastrically ciprofloxacin on day 8, while RLQ group 2 and control group 2 were given intragastrically sulfamethoxazole and trimethoprim on day 8. Blood samples were collected and determined. There was no significant influence of pharmacokinetic parameters of trimethoprim on two groups. But some pharmacokinetic parameters of ciprofloxacin and sulfamethoxazole in RLQ pretreated rats were evidently altered (P < 0.05), which indicated that absorption of ciprofloxacin and sulfamethoxazole in RLQ pretreated rats was significantly affected. It indicated the coadministration of RLQ would have an influence on the efficacy of ciprofloxacin and sulfamethoxazole, and the doses of ciprofloxacin tablet and compound sulfamethoxazole tablet need adjustment.
Provincial Key Laboratory of Pharmaceutics in Guizhou Province, No. 9, Beijing Road, Yunyan District, Guiyang 550004, China; School of Pharmacy, Guizhou Medical University, No. 9, Beijing Road, Yunyan District, Guiyang 550004, China; National Engineering Research Center of Miao's Medicines, No. 9, Beijing Road, Yunyan District, Guiyang 550004, China.
Yuan
Y
Lu
Provincial Key Laboratory of Pharmaceutics in Guizhou Province, No. 9, Beijing Road, Yunyan District, Guiyang 550004, China; School of Pharmacy, Guizhou Medical University, No. 9, Beijing Road, Yunyan District, Guiyang 550004, China.
ZiPeng
0000-0003-2074-9476
Z
Gong
School of Pharmacy, Guizhou Medical University, No. 9, Beijing Road, Yunyan District, Guiyang 550004, China.
YuMin
Y
Xie
School of Pharmacy, Guizhou Medical University, No. 9, Beijing Road, Yunyan District, Guiyang 550004, China.
Jie
J
Pan
Provincial Key Laboratory of Pharmaceutics in Guizhou Province, No. 9, Beijing Road, Yunyan District, Guiyang 550004, China; School of Pharmacy, Guizhou Medical University, No. 9, Beijing Road, Yunyan District, Guiyang 550004, China.
Jia
J
Sun
Provincial Key Laboratory of Pharmaceutics in Guizhou Province, No. 9, Beijing Road, Yunyan District, Guiyang 550004, China; School of Pharmacy, Guizhou Medical University, No. 9, Beijing Road, Yunyan District, Guiyang 550004, China.
YueTing
Y
Li
Provincial Key Laboratory of Pharmaceutics in Guizhou Province, No. 9, Beijing Road, Yunyan District, Guiyang 550004, China; School of Pharmacy, Guizhou Medical University, No. 9, Beijing Road, Yunyan District, Guiyang 550004, China.
SiYing
S
Chen
School of Pharmacy, Guizhou Medical University, No. 9, Beijing Road, Yunyan District, Guiyang 550004, China; Engineering Research Center for the Development and Application of Ethnic Medicine and TCM, Ministry of Education, No. 9, Beijing Road, Yunyan District, Guiyang 550004, China.
YongJun
Y
Li
Provincial Key Laboratory of Pharmaceutics in Guizhou Province, No. 9, Beijing Road, Yunyan District, Guiyang 550004, China; School of Pharmacy, Guizhou Medical University, No. 9, Beijing Road, Yunyan District, Guiyang 550004, China.
YongLin
0000-0002-7109-2825
Y
Wang
Provincial Key Laboratory of Pharmaceutics in Guizhou Province, No. 9, Beijing Road, Yunyan District, Guiyang 550004, China; School of Pharmacy, Guizhou Medical University, No. 9, Beijing Road, Yunyan District, Guiyang 550004, China.
Yong
0000-0002-4328-6948
Y
Huang
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