Case Report of Subcutaneous Nodules and Sterile Abscesses Due to Delayed Type Hypersensitivity to Aluminum-Containing Vaccines.
Routine childhood immunizations have resulted in great reductions in vaccine-preventable infectious diseases. Vaccine-related adverse events, albeit rare, can be of significant consequence. Although anaphylaxis, or type I hypersensitivity, is recognized as a potential reaction after vaccination, delayed type hypersensitivity or type IV reactions are less so. We present a case of persistent subcutaneous nodules and sterile abscesses in the setting of delayed type hypersensitivity to aluminum, confirmed by patch testing and recurrence on re-exposure. We review sources of aluminum in common immunizations, principles for treatment, and strategies for management of future vaccinations for this patient.
Departments of Dermatology, and cat35@cumc.columbia.edu.|Pediatrics, Columbia University Medical Center, New York, New York.
Christine T
CT
Lauren
Departments of Dermatology, and.
Donald V
DV
Belsito
Departments of Dermatology, and.|Pediatrics, Columbia University Medical Center, New York, New York.
Kimberly D
KD
Morel
Pediatrics, Columbia University Medical Center, New York, New York.
Philip
P
LaRussa
D000038:Abscess / Q000209:etiology*; D000535:Aluminum / Q000009:adverse effects*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007223:Infant; D008297:Male; D010328:Patch Tests; D014612:Vaccines / Q000009:adverse effects*
D014612:Vaccines; D000535:Aluminum