Kidney Transplantation From a Donor With Sickle Cell Disease.
In the United States, >100 000 patients are waiting for a kidney transplant. Given the paucity of organs available for transplant, expansion of eligibility criteria for deceased donation is of substantial interest. Sickle cell disease (SCD) is viewed as a contraindication to kidney donation, perhaps because SCD substantially alters renal structure and function and thus has the potential to adversely affect multiple physiological processes of the kidney. To our knowledge, transplantation from a donor with SCD has never been described in the literature. In this paper, we report the successful transplantation of two kidneys from a 37-year-old woman with SCD who died from an intracranial hemorrhage. Nearly 4 mo after transplant, both recipients are doing well and are off dialysis. The extent to which kidneys from donors with SCD can be safely transplanted with acceptable outcomes is unknown; however, this report should provide support for the careful expansion of kidneys from donors with SCD without evidence of renal dysfunction and with normal tissue architecture on preimplantation biopsies.
Department of Surgery, The Hospital of the University of Pennsylvania, Philadelphia, PA.
A
A
Rossidis
Division of Nephrology, Department of Medicine, The Hospital of the University of Pennsylvania, Philadelphia, PA.
M A
MA
Lim
Department of Pathology and Laboratory Medicine, The Hospital of the University of Pennsylvania, Philadelphia, PA.
M
M
Palmer
Department of Surgery, The Hospital of the University of Pennsylvania, Philadelphia, PA.
M H
MH
Levine
Department of Surgery, The Hospital of the University of Pennsylvania, Philadelphia, PA.
A
A
Naji
Division of Nephrology, Department of Medicine, The Hospital of the University of Pennsylvania, Philadelphia, PA.
R D
RD
Bloom
Department of Surgery, The Hospital of the University of Pennsylvania, Philadelphia, PA.
P L
PL
Abt
D000328:Adult; D000755:Anemia, Sickle Cell; D002102:Cadaver; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation / Q000379:methods*; D008875:Middle Aged; D009392:Nephrectomy; D011379:Prognosis; D014019:Tissue Donors; D009927:Tissue and Organ Procurement / Q000379:methods*
clinical research/practice; donors and donation: deceased; donors and donation: donor evaluation; editorial/personal viewpoint; kidney transplantation/nephrology; organ procurement and allocation
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