Bacterial Hyaluronidase Self-Triggered Prodrug Release for Chemo-Photothermal Synergistic Treatment of Bacterial Infection.
A novel platform for targeted on-demand prodrug ascorbic acid (AA) delivery is fabricated using a bacterial hyaluronidase sensitive graphene-mesoporous silica nanosheet@hyaluronic acid-magnetic nanoparticles as the nanocarrier to treat bacterial infections. The released AA can be converted to detrimental •OH in situ on the surface of bacteria. With the chemo-photothermal synergistic effect, the designed antibacterial system can effectively inactivate bacteria and disperse stubborn biofilm.
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.|Graduate School University of Chinese Academy of Sciences, Beijing, 100039, China.
Haiwei
H
Ji
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.
Kai
K
Dong
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.|Graduate School University of Chinese Academy of Sciences, Beijing, 100039, China.
Zhengqin
Z
Yan
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.|Graduate School University of Chinese Academy of Sciences, Beijing, 100039, China.
Chao
C
Ding
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.|Graduate School University of Chinese Academy of Sciences, Beijing, 100039, China.
Zhaowei
Z
Chen
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.
Jinsong
J
Ren
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.
Xiaogang
X
Qu
D001205:Ascorbic Acid / Q000737:chemistry / Q000494:pharmacology; D001424:Bacterial Infections / Q000517:prevention & control; D001426:Bacterial Proteins / Q000737:chemistry*; D016503:Drug Delivery Systems; D006821:Hyaluronoglucosaminidase / Q000737:chemistry* / Q000378:metabolism; D011355:Prodrugs / Q000737:chemistry* / Q000494:pharmacology*
D001426:Bacterial Proteins; D011355:Prodrugs; D006821:Hyaluronoglucosaminidase; D001205:Ascorbic Acid
antibacterial system; drug delivery; hyaluronic acid; on-demand; reactive oxygen species