Decorin interacting network: A comprehensive analysis of decorin-binding partners and their versatile functions.
Decorin, a prototype small leucine-rich proteoglycan, regulates a vast array of cellular processes including collagen fibrillogenesis, wound repair, angiostasis, tumor growth, and autophagy. This functional versatility arises from a wide array of decorin/protein interactions also including interactions with its single glycosaminoglycan side chain. The decorin-binding partners encompass numerous categories ranging from extracellular matrix molecules to cell surface receptors to growth factors and enzymes. Despite the diversity of the decorin interacting network, two main roles emerge as prominent themes in decorin function: maintenance of cellular structure and outside-in signaling, culminating in anti-tumorigenic effects. Here we present contemporary knowledge regarding the decorin interacting network and discuss in detail the biological relevance of these pleiotropic interactions, some of which could be targeted by therapeutic interventions.
Department of Pathology, Anatomy, and Cell Biology and the Cancer Cell Biology and Signaling Program, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, United States.
Maria A
MA
Gubbiotti
Pericellular and Extracellular Supramolecular Assemblies, Institute of Molecular and Supramolecular Chemistry and Biochemistry, University Claude Bernard, Lyon, France.
Sylvain D
SD
Vallet
Pericellular and Extracellular Supramolecular Assemblies, Institute of Molecular and Supramolecular Chemistry and Biochemistry, University Claude Bernard, Lyon, France.
Sylvie
S
Ricard-Blum
Department of Pathology, Anatomy, and Cell Biology and the Cancer Cell Biology and Signaling Program, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, United States. Electronic address: renato.iozzo@jefferson.edu.
Renato V
RV
Iozzo
D000818:Animals; D003094:Collagen / Q000502:physiology; D058575:Decorin / Q000502:physiology*; D005109:Extracellular Matrix / Q000502:physiology*; D006025:Glycosaminoglycans / Q000502:physiology; D006801:Humans; D060066:Protein Interaction Maps; D011509:Proteoglycans / Q000502:physiology; D015398:Signal Transduction
D058575:Decorin; D006025:Glycosaminoglycans; D011509:Proteoglycans; D003094:Collagen
Angiogenesis; Autophagy; Binding-partners; Decorin; Extracellular matrix; Proteoglycan; Tumorigenesis
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