Kluyvera ascorbata Strain from Hospital Sewage Carrying the mcr-1 Colistin Resistance Gene.
The newly identified plasmid-borne colistin resistance gene mcr-1 was found in a Kluyvera ascorbata isolate from hospital sewage in China. mcr-1 was carried by a 57-kb self-transmissible IncI2 plasmid. Unlike in a previous report, mcr-1 was not associated with ISApl1 and was inserted into a gene encoding a putative membrane protein by an unknown mechanism. This study highlights that mcr-1 has spread to multiple bacterial species.
Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
Feifei
F
Zhao
Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China zongzhiy@scu.edu.cn.
Zhiyong
Z
Zong
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002681:China; D003091:Colistin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D004756:Enterobacteriaceae Infections / Q000382:microbiology; D015870:Gene Expression; D005798:Genes, Bacterial; D006761:Hospitals; D006801:Humans; D044086:Kluyvera / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D016254:Mutagenesis, Insertional; D010957:Plasmids / Q000737:chemistry / Q000378:metabolism*; D012722:Sewage / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D008565:Membrane Proteins; D012722:Sewage; D003091:Colistin
Bioinformatics. 2014 Jul 15;30(14):2068-9
24642063
Lancet Infect Dis. 2016 Mar;16(3):289-90
26973304
Lancet Infect Dis. 2016 Mar;16(3):281-2
26774244
Antimicrob Agents Chemother. 2004 Dec;48(12):4895-7
15561876
Lancet Infect Dis. 2016 Mar;16(3):285-6
26774239
Lancet Infect Dis. 2016 Feb;16(2):147-9
26711361
Lancet Infect Dis. 2016 Mar;16(3):288-9
26842777
Euro Surveill. 2015;20(49):null
26676364
Lancet Infect Dis. 2016 Mar;16(3):282-3
26774242
Lancet Infect Dis. 2016 Mar;16(3):286-7
26774248
Lancet Infect Dis. 2016 Feb;16(2):146-7
26711359
Lancet Infect Dis. 2016 Mar;16(3):281
26774246
Lancet Infect Dis. 2016 Feb;16(2):161-8
26603172
Front Microbiol. 2014 Nov 26;5:643
25505462
Lancet Infect Dis. 2016 Feb;16(2):144-5
26711363
Lancet Infect Dis. 2016 Feb;16(2):145-6
26711362
Appl Environ Microbiol. 1995 Mar;61(3):1104-9
7793912
Lancet Infect Dis. 2016 Feb;16(2):147
26711360
Lancet Infect Dis. 2016 Mar;16(3):284-5
26774245
J Comput Biol. 2012 May;19(5):455-77
22506599
J Gen Microbiol. 1984 Jun;130(6):1489-502
6148378
Lancet Infect Dis. 2016 Mar;16(3):283-4
26774247