Cascade Reactions of Nitrones and Allenes for the Synthesis of Indole Derivatives.
Cascade reactions involving nitrones and allenes are known to facilitate the rapid synthesis of several indole derivatives. The chemoselectivity of these complicated transformations can be influenced by substrate functionalization, reaction conditions, and catalyst control. While seminal studies established primary reactivity patterns, recent work has illustrated the impact of these cascade reactions for creating diverse libraries, increased the breadth of these methods with facilitated access to challenging nitrones, and shown that these transformations can be controlled by asymmetric catalysis.
Department of Chemistry, University of Illinois at Chicago , Chicago, Illinois 60607, United States.
Laura L
LL
Anderson
Department of Chemistry, University of Illinois at Chicago , Chicago, Illinois 60607, United States.
Michelle A
MA
Kroc
Department of Chemistry, University of Illinois at Chicago , Chicago, Illinois 60607, United States.
Tyler W
TW
Reidl
Department of Chemistry, University of Illinois at Chicago , Chicago, Illinois 60607, United States.
Jongwoo
J
Son