Dietary Reversal Ameliorates Short- and Long-Term Memory Deficits Induced by High-fat Diet Early in Life.
A high-fat diet (HFD), one of the major factors contributing to metabolic syndrome, which is associated with an increased risk of neurodegenerative diseases, leads to insulin resistance and cognitive impairment. It is not known whether these alterations are improved with dietary intervention. To investigate the long-term impact of a HFD on hippocampal insulin signaling and memory, C57BL6 mice were placed into one of three groups based on the diet: a standard diet (control), a HFD, or a HFD for 16 weeks and then the standard diet for 8 weeks (HF16). HFD-induced impairments in glucose tolerance and hippocampal insulin signaling occurred concurrently with deficits in both short- and long-term memory. Furthermore, these conditions were improved with dietary intervention; however, the HFD-induced decrease in insulin receptor expression in the hippocampus was not altered with dietary intervention. Our results demonstrate that memory deficits due to the consumption of a HFD at an early age are reversible.
Department of Neurology, Medical University of South Carolina, Charleston, South Carolina, 29425, United States of America.|Department of Neurology, University of Michigan, Ann Arbor, Michigan, 48109, United States of America.
Catrina
C
Sims-Robinson
Department of Neurology, University of Michigan, Ann Arbor, Michigan, 48109, United States of America.
Anna
A
Bakeman
Department of Neurology, University of Michigan, Ann Arbor, Michigan, 48109, United States of America.
Elizabeth
E
Bruno
Department of Neurology, University of Michigan, Ann Arbor, Michigan, 48109, United States of America.
Samuel
S
Jackson
Department of Neurology, University of Michigan, Ann Arbor, Michigan, 48109, United States of America.
Rebecca
R
Glasser
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, 48109, United States of America.|Department of Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan, 48109, United States of America.
Geoffrey G
GG
Murphy
Department of Neurology, University of Michigan, Ann Arbor, Michigan, 48109, United States of America.
Eva L
EL
Feldman
Diabetes. 2005 Mar;54(3):657-63
15734840
Eur J Clin Invest. 2002 Jun;32 Suppl 3:3-13
12028370
Diabetes Res Clin Pract. 2014 Aug;105(2):141-50
24798950
BMJ. 2005 Jun 11;330(7504):1360
15863436
Neurobiol Learn Mem. 2013 Oct;105:174-85
23835143
J Cereb Blood Flow Metab. 2016 Jul;36(7):1257-70
26661233
Dis Model Mech. 2014 Jun;7(6):625-33
24764191
J Clin Invest. 2000 Jul;106(2):165-9
10903329
Brain Behav Immun. 2014 Aug;40:9-17
24662056
Annu Rev Pharmacol Toxicol. 1996;36:615-58
8725404
Endocr Rev. 1995 Apr;16(2):117-42
7781591
Curr Biol. 2013 Sep 9;23(17):1685-90
23954431
J Clin Endocrinol Metab. 2009 Nov;94(11):4258-66
19808853
Nature. 2002 Nov 21;420(6913):333-6
12447443
Learn Mem. 2006 Sep-Oct;13(5):584-9
17015855
Nutr Neurosci. 2008 Apr;11(2):48-54
18510803
Exp Neurol. 2016 Mar;277:261-7
26775176
Nat Rev Neurol. 2012 Jun 19;8(7):360-2
22710630
Life Sci. 2011 Mar 28;88(13-14):619-27
21315737
Diabetologia. 2012 Aug;55(8):2276-84
22581041
Antioxid Redox Signal. 2011 May 15;14 (10 ):1829-39
21194385
Diabetologia. 2003 Dec;46(12):1629-40
14600817
Cell. 2010 Mar 19;140(6):900-17
20303879
Am J Physiol Endocrinol Metab. 2009 Oct;297(4):E898-906
19638508
Diabetes. 2013 Aug;62(8):2747-51
23493575
J Biol Chem. 2000 Mar 24;275(12):9047-54
10722755
JAMA. 2004 Nov 10;292(18):2237-42
15536110
J Biol Chem. 1992 Aug 15;267(23):16660-8
1322912
Biol Sex Differ. 2016 Jan 28;7:9
26823968
J Alzheimers Dis. 2008 Jun;14 (2):133-45
18560126
Diabetes. 2006 Aug;55(8):2392-7
16873706
J Clin Invest. 1998 Apr 1;101(7):1353-61
9525977
Diabetes Obes Metab. 2010 Oct;12(10):891-9
20920042
Endocrinology. 2005 Mar;146(3):1576-87
15591151
J Neural Transm (Vienna). 1998;105(4-5):423-38
9720972
Physiol Behav. 2011 Apr 18;103(1):10-6
21241723
Neurobiol Dis. 2014 Jul;67:79-87
24686304
BMC Neurosci. 2014 Sep 25;15:111
25257559
Hippocampus. 2005;15(3):340-6
15744736
Pharmacol Ther. 2012 Oct;136(1):82-93
22820012
Nat Rev Neurol. 2010 Oct;6(10):551-9
20842183
Arch Med Sci. 2015 Jun 19;11(3):463-82
26170839
Biochim Biophys Acta. 2015 Sep;1852(9):1687-99
26003667
Science. 2003 Dec 5;302(5651):1710-1
14657487
Int J Obes (Lond). 2008 Dec;32 Suppl 7:S52-4
19136991
Science. 2004 Oct 15;306(5695):457-61
15486293
Novartis Found Symp. 2007;286:86-94; discussion 94-8, 162-3, 196-203
18269176
Cell Mol Neurobiol. 2015 Oct;35(7):1061-71
25939427
Nature. 2004 Sep 9;431(7005):200-5
15306821
Neurobiol Learn Mem. 2010 May;93(4):546-53
20176121
Diabetes. 2005 Dec;54 Suppl 2:S73-8
16306344
Eur J Pharmacol. 2013 Nov 5;719(1-3):34-43
23872402
Biochem Biophys Res Commun. 2005 Sep 30;335(3):836-42
16099428
Mol Neurobiol. 2017 Mar;54(2):983-996
26797519
Epidemiol Rev. 2007;29:29-48
17478442
JAMA. 2015 May 19;313(19):1973-4
25988468
FASEB J. 2001 Oct;15(12):2099-111
11641236
Int J Obes Relat Metab Disord. 2002 Jul;26(7):897-904
12080441
Mech Ageing Dev. 2000 Feb 15;113(3):227-32
10714941
Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3100-5
14981233
Diabetes. 2002 Dec;51(12 ):3384-90
12453890
J Alzheimers Dis. 2015;45(3):823-35
25624414
Science. 1998 Apr 24;280(5363):517-9
9575095
Mol Neurobiol. 2016 May;53(4):2287-96
25976368
Neurobiol Learn Mem. 2013 Nov;106:18-25
23820496
Mol Cell Biol. 1997 Nov;17(11):6633-44
9343427
Hippocampus. 2012 Nov;22(11):2095-100
22593080
Arch Neurol. 2012 Jan;69(1):29-38
21911655
Hippocampus. 2005;15(2):260-72
15523608
Neuroendocrinology. 2001 Oct;74(4):270-80
11598383
Endocrinology. 1995 Dec;136(12):5291-7
7588273