Cardiovascular risk evaluation through heart rate variability analysis in psoriatic patients before and after 24 weeks of etanercept therapy: Prospective study.
OBJECTIVE
To assess the influence of etanercept, an anti-tumour necrosis factor (TNF)-α agent, on autonomic cardiovascular regulation in young patients with moderate-to-severe psoriasis without cardiovascular risk factors.


METHODS
Patients with psoriasis underwent 5-min electrocardiogram (ECG) recordings before and after 24 weeks of etanercept therapy. Linear heart rate variability (HRV) analysis was performed.


RESULTS
The study recruited 19 patients. Frequency-domain analysis showed a significant decrease in oscillatory components attributable to sympathetic activity (LF%) and a significant decrease in low frequency/high frequency (LF/HF) ratio following etanercept therapy.


CONCLUSIONS
Treatment with etanercept in patients with moderate-to-severe psoriasis could affect cardiovascular autonomic regulation, and subsequently reduce cardiovascular risk.
Department of Medical and Surgical Sciences and Biotechnologies, Division of Dermatology "Daniele Innocenzi", University of Rome "La Sapienza", Polo Pontino, Italy concetta.potenza@uniroma1.it.
Concetta
C
Potenza
Department of Medical and Surgical Sciences and Biotechnologies, Faculty of Pharmacy and Medicine, University of Rome "Sapienz'', Italy.
Gianfranco
G
Raimondi
Department of Medical and Surgical Sciences and Biotechnologies, Division of Dermatology "Daniele Innocenzi", University of Rome "La Sapienza", Polo Pontino, Italy.
Riccardo
R
Pampena
Department of Medical and Surgical Sciences and Biotechnologies, Division of Dermatology "Daniele Innocenzi", University of Rome "La Sapienza", Polo Pontino, Italy.
Ilaria
I
Proietti
Department of Medical and Surgical Sciences and Biotechnologies, Division of Dermatology "Daniele Innocenzi", University of Rome "La Sapienza", Polo Pontino, Italy.
Giorgio La
G
Viola
Department of Medical and Surgical Sciences and Biotechnologies, Division of Dermatology "Daniele Innocenzi", University of Rome "La Sapienza", Polo Pontino, Italy.
Nicoletta
N
Bernardini
Department of Medical and Surgical Sciences and Biotechnologies, Division of Dermatology "Daniele Innocenzi", University of Rome "La Sapienza", Polo Pontino, Italy.
Ersilia
E
Tolino
Department of Medical and Surgical Sciences and Biotechnologies, Division of Dermatology "Daniele Innocenzi", University of Rome "La Sapienza", Polo Pontino, Italy.
Sara
S
Zuber
Department of Medical and Surgical Sciences and Biotechnologies, Division of Dermatology "Daniele Innocenzi", University of Rome "La Sapienza", Polo Pontino, Italy.
Veronica
V
Balduzzi
Department of Medical and Surgical Sciences and Biotechnologies, Faculty of Pharmacy and Medicine, University of Rome "Sapienz'', Italy.
Beatrice
B
Scordamaglia
Department of Medical and Surgical Sciences and Biotechnologies, Division of Dermatology "Daniele Innocenzi", University of Rome "La Sapienza", Polo Pontino, Italy.
Nevena
N
Skroza
Autonomic nervous system; cardiovascular; etanercept; heart rate variability; psoriasis
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