Parkinson's disease psychosis as a serotonin-dopamine imbalance syndrome.
Parkinson's disease psychosis (PDP) is theoretically a serotonin-dopamine imbalance syndrome due to disruption of the normal balance between the serotonergic and dopaminergic neurotransmitter systems in key brain circuits.
Stephen M
SM
Stahl
D000978:Antiparkinson Agents / Q000009:adverse effects; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001921:Brain / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D007980:Levodopa / Q000009:adverse effects; D016631:Lewy Bodies / Q000378:metabolism*; D010300:Parkinson Disease / Q000150:complications / Q000378:metabolism* / Q000523:psychology; D010880:Piperidines / Q000627:therapeutic use; D011618:Psychotic Disorders / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism* / Q000523:psychology; D044402:Receptor, Serotonin, 5-HT2A / Q000378:metabolism*; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D014508:Urea / Q000031:analogs & derivatives / Q000627:therapeutic use
D000978:Antiparkinson Agents; D014150:Antipsychotic Agents; D010880:Piperidines; D044402:Receptor, Serotonin, 5-HT2A; D017448:Receptors, Dopamine D2; D012701:Serotonin; D007980:Levodopa; D014508:Urea; C510793:pimavanserin; D004298:Dopamine