Association of the HOTAIR rs4759314 polymorphism with cancer risk: a meta-analysis.
OBJECTIVE
To explore the association between HOTAIR rs4759314 and cancer risk.


METHODS
A comprehensive online search was conducted using PubMed, EMBASE, and CNKI databases to identify relevant studies. The case-control studies related to HOTAIR rs4759314 polymorphism and cancer risk were selected according to the inclusion and exclusion criteria. The retrieval time was until November 2015. After extracting the basic data information and performing an evaluation of the quality of the literature, the meta-analysis was performed using STATA 12.0 software, by calculating the odds ratio (OD) and 95% confidence interval (95% CI), and further subgroup analysis, literature publication bias testing, and sensitivity analysis.


RESULTS
The studies included a total of 5025 patients with cancer and 5657 controls. The results found no significant association between the HOTAIR rs4759314 polymorphism and cancer risk in a Chinese population (G vs A, OR=1.06, 95% CI :0.87-1.30 ; GG/GA vs AA, OR=1.07, 95% CI: 0.87-1.32; GG vs GA/AA, OR=0.75, 95% CI:0.39-1.43; GA vs AA, OR=1.08, 95% CI: 0.88-1.33; GG vs AA, OR=0.76, 95% CI:0.39-1.45) (all p<0.05). However, A allelic gene was associated with lower risk of gastric cancer, while G allelic gene may act as a genetic susceptibility factor for gastric cancer in Chinese population.


CONCLUSIONS
No significant association was noted between the HOTAIR rs4759314 polymorphism and cancer risk in a Chinese population.
Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330000, Jiangxi Province, China.
Fang-Teng
FT
Liu
Liang
L
Zhou
Cheng
C
Qiu
Guangfeng
G
Xia
Pei-Qian
PQ
Zhu
Hong-Liang
HL
Luo
D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000235:genetics*; D012307:Risk Factors
C561566:HOTAIR long untranslated RNA, human; D062085:RNA, Long Noncoding