25-hydroxyvitamin D is associated with metabolic syndrome among premenopausal women with systemic lupus erythematosus in China.
Objectives This study aimed to investigate the status of 25-hydroxyvitamin D (25(OH)D) and its association with metabolic syndrome (MS) and different MS components among premenopausal women with systemic lupus erythematosus (SLE) in China. Patients and methods Altogether 113 premenopausal women with SLE and the age-matched healthy cohorts were recruited in this cross-sectional study. Clinical manifestations and laboratory data including serum 25(OH)D concentration were collected. A multivariable analysis was performed to analyze the association of 25(OH)D with MS and its components. Results The prevalence of 25(OH)D deﬁciency (25(OH)D < 20 ng/ml) and MS were common (24.8% and 30.1%, respectively) in premenopausal patients with SLE in China. Analysis of the association between 25(OH)D, MS and its components demonstrated that the lower level of 25(OH)D was associated with increased MS prevalence (OR = 0.920, p = 0.012), a decreased level of high-density lipoprotein (OR = 1.059, p = 0.033) and a higher level of fasting glucose (OR = 0.810, p = 0.004). These associations were still detectible after adjustment for age, body mass index and SLE-related variables. Conclusion The level of 25(OH)D is associated with MS and its components in premenopausal women with SLE.
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
L-M
LM
Wang
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Z-H
ZH
Zheng
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
T-F
TF
Li
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
L-S
LS
Han
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Y-J
YJ
He
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Y-L
YL
Zhang
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
H-L
HL
Zeng
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
S-Y
SY
Liu
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000097:blood*; D024821:Metabolic Syndrome / Q000097:blood* / Q000201:enzymology; D017697:Premenopause; D012307:Risk Factors; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood*; D055815:Young Adult
D001786:Blood Glucose; D008075:Lipoproteins, HDL; D014807:Vitamin D; C104450:25-hydroxyvitamin D
25-hydroxyvitamin D; metabolic syndrome; systemic lupus erythematosus