First-in-man observation of Talaromyces marneffei-transmission by organ transplantation.
A lung transplant recipient was diagnosed with penicilliosis due to Talaromyces marneffei, a fungus endemic in South-East Asia, which was acquired by donor transmission. This first case of Talaromyces marneffei-transmission by transplantation underscores that current globalisation of travelling necessitates increased vigilance for transmission of unusual pathogens in organ recipients.
Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium.
Frederik
F
Hermans
Department of Laboratory Medicine, National Reference Center for Mycosis, University Hospitals Leuven, Leuven, Belgium.|Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.
Sien
S
Ombelet
Department of Abdominal Transplant Surgery & Transplant Coordination, University Hospitals Leuven, Leuven, Belgium.
Karlien
K
Degezelle
Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium.
Dries
D
Testelmans
Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium.|Department of Experimental Thoracic Surgery, KU Leuven, Leuven, Belgium.
Dirk E
http://orcid.org/0000-0003-1261-0992
DE
Van Raemdonck
Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium.|Department of Clinical and Experimental Medicine, Division of Respiratory Diseases, KU Leuven, Leuven, Belgium.
Geert M
GM
Verleden
Department of Histopathology, KU Leuven, Leuven, Belgium.
Eric K
EK
Verbeken
Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium.
Pascal
P
Van Bleyenbergh
Department of Laboratory Medicine, National Reference Center for Mycosis, University Hospitals Leuven, Leuven, Belgium.|Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.
Katrien
http://orcid.org/0000-0001-8668-1350
K
Lagrou
Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium.|Department of Clinical and Experimental Medicine, Division of Respiratory Diseases, KU Leuven, Leuven, Belgium.
Robin
http://orcid.org/0000-0002-3468-9251
R
Vos
D000935:Antifungal Agents / Q000627:therapeutic use; D001210:Asia, Southeastern; D006801:Humans; D016867:Immunocompromised Host; D008168:Lung / Q000382:microbiology*; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology* / Q000635:transmission*; D032901:Talaromyces / Q000302:isolation & purification*; D014057:Tomography, X-Ray Computed; D014195:Travel
D000935:Antifungal Agents
emerging disease; fungal infection; infection by mode of transmission; lung transplantation; penicilliosis; zoonotic infection