Skin metastases of cervical cancer: two case reports and review of the literature.
BACKGROUND
Although cervix carcinoma is one of the most common malignancies in women, hematogenous metastases are relatively not common. Cutaneous metastases, in particular, are unusual even at an advanced stage of disease. Their presence is a predictor of poor prognosis.


METHODS
Case 1: A 63-year-old postmenopausal Moroccan woman was diagnosed as having cervical squamous cell carcinoma. She was treated with radical concurrent chemotherapy and radiation therapy followed by low-dose brachytherapy. Six months after finishing the therapy, multiple skin nodules appeared on her abdomen and chest wall. An excision biopsy was performed and showed metastatic squamous cell carcinoma. Her disease progressed and she died before completing her fourth course of palliative chemotherapy. Case 2: A 48-year-old Moroccan woman was diagnosed as having cervical squamous cell carcinoma; she was treated with concurrent chemoradiation. Before a planned high-dose brachytherapy, she noticed many nodular lesions on her arms, thighs, and chest wall. An excision biopsy was performed and showed metastatic squamous cell carcinoma. She then underwent a series of imaging examinations, including computed tomography of her chest, abdomen, and pelvis, and a whole body bone scan that showed disseminated disease involving her lungs and bones. She died after two courses of palliative chemotherapy, 2 months after the appearance of the skin lesions.


CONCLUSIONS
We report two cases to illustrate a rare localization of metastasis from cervical carcinoma that is highly aggressive requiring early detection and aggressive management.
Department of Radiotherapy, National Institute of Oncology, Mohammed V University, Rabat, Morocco. mery-ben23@hotmail.com.
Meryem
M
Benoulaid
Department of Radiotherapy, National Institute of Oncology, Mohammed V University, Rabat, Morocco.
Hanan
H
Elkacemi
Department of Radiotherapy, National Institute of Oncology, Mohammed V University, Rabat, Morocco.
Imane
I
Bourhafour
Department of Radiotherapy, National Institute of Oncology, Mohammed V University, Rabat, Morocco.
Jihane
J
Khalil
Department of Radiotherapy, National Institute of Oncology, Mohammed V University, Rabat, Morocco.
Sanaa
S
Elmajjaoui
Department of Pathology, National Institute of Oncology, Mohammed V University, Rabat, Morocco.
Basma
B
Khannoussi
Department of Radiotherapy, National Institute of Oncology, Mohammed V University, Rabat, Morocco.
Tayeb
T
Kebdani
Department of Radiotherapy, National Institute of Oncology, Mohammed V University, Rabat, Morocco.
Noureddine
N
Benjaafar
Carcinoma of the uterine cervix; Case report; Skin metastasis
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