Echocardiographic associates of atrial fibrillation in end-stage renal disease.
BACKGROUND
The prevalence of atrial fibrillation (AF) in end-stage renal disease (ESRD) patients is relatively high. The present study evaluated the association between left atrial (LA) remodelling, including an increased size and myocardial fibrosis, and slow LA conduction and the occurrence of AF.


METHODS
In 171 ESRD patients enrolled in the Implantable Cardioverter Defibrillators in Dialysis patients (ICD2) trial, the LA dimensions, LA conduction delay [as reflected by the time difference between P-wave onset on surface electrocardiogram and A'-wave on tissue Doppler imaging (PA-TDI)] and LA function were compared between patients who exhibited AF versus patients without AF. Based on ICD remote monitoring or clinical records, the occurrence of AF was detected.


RESULTS
Of 171 patients, 47 (27%) patients experienced AF. Despite comparable left ventricular ejection fraction and prevalence of significant mitral regurgitation, patients with AF had significantly larger LA volume index (mean ± standard deviation) (29 ± 11 versus 23 ± 10 mL/m2, P = 0.001), longer PA-TDI duration (144 ± 30 versus 131 ± 27 ms, P = 0.010) and reduced late diastolic mitral annular velocity (A') (7.1 ± 2.8 versus 8.2 ± 2.4 cm/s, P = 0.012) compared with patients without AF. On multivariable analysis, larger LA volume index [odds ratio (OR) 1.04, 95% confidence interval (CI) 1.01-1.08, P = 0.017], longer PA-TDI duration (OR 1.02, 95% CI 1.00-1.03, P = 0.025) and reduced A' (OR 0.84, 95% CI 0.72-0.98, P = 0.025) were independently associated with AF after adjusting for age and left ventricle diastolic relaxation.


CONCLUSIONS
ESRD patients with AF show more advanced changes in the LA substrate than ESRD patients without AF.
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Liselotte C R
LCR
Hensen
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Victoria
V
Delgado
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Suzanne E
SE
van Wijngaarden
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Melissa
M
Leung
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Mihaly K
MK
de Bie
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Maurits S
MS
Buiten
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Martin J
MJ
Schalij
Department of Nephrology, Bernhoven Medical Center, Uden, The Netherlands.
Jos J
JJ
Van de Kerkhof
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.
Ton J
TJ
Rabelink
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.
Joris I
JI
Rotmans
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
J Wouter
JW
Jukema
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Jeroen J
JJ
Bax
D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D015150:Echocardiography, Doppler / Q000379:methods*; D004562:Electrocardiography; D005260:Female; D006325:Heart Atria / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors
atrial fibrillation; echocardiography; end-stage renal disease; left atrium; tissue Doppler imaging