Which SSRIs most effectively treat depression in adolescents?
We don't know which selective serotonin reuptake inhibitors (SSRIs) are the most effective and safe because no studies have compared these antidepressants with each other. Three SSRI antidepressant medications--fluoxetine, sertraline, and escitalopram--produce modest improvements (about 5% to 10%) in standardized depression scores without a significant increase in the risk of suicide-related outcomes (suicidal behavior or ideation) in adolescent patients with major depression of moderate severity.
Valley Family Medicine Residency, University of Washington at Renton, WA, USA.
Valory
V
DeLucia
Valley Family Medicine Residency, University of Washington at Renton, WA, USA.
Gary
G
Kelsberg
University of Washington Health Science Library, Seattle, WA, USA.
Sarah
S
Safranek
D000293:Adolescent; D000294:Adolescent Behavior / Q000187:drug effects*; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001521:Behavior Therapy; D015283:Citalopram / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D018570:Risk Assessment; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D020280:Sertraline / Q000627:therapeutic use*
D000928:Antidepressive Agents; D015283:Citalopram; D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline