Effects of tissue susceptibility on brain temperature mapping.
A method for mapping of temperature over a large volume of the brain using volumetric proton MR spectroscopic imaging has been implemented and applied to 150 normal subjects. Magnetic susceptibility-induced frequency shifts in gray- and white-matter regions were measured and included as a correction in the temperature mapping calculation. Additional sources of magnetic susceptibility variations of the individual metabolite resonance frequencies were also observed that reflect the cellular-level organization of the brain metabolites, with the most notable differences being attributed to changes of the N-Acetylaspartate resonance frequency that reflect the intra-axonal distribution and orientation of the white-matter tracts with respect to the applied magnetic field. These metabolite-specific susceptibility effects are also shown to change with age. Results indicate no change of apparent brain temperature with age from 18 to 84 years old, with a trend for increased brain temperature throughout the cerebrum in females relative for males on the order of 0.1°C; slightly increased temperatures in the left hemisphere relative to the right; and a lower temperature of 0.3°C in the cerebellum relative to that of cerebral white-matter. This study presents a novel acquisition method for noninvasive measurement of brain temperature that is of potential value for diagnostic purposes and treatment monitoring, while also demonstrating limitations of the measurement due to the confounding effects of tissue susceptibility variations.
Department of Radiology, University of Miami, Miami, FL, USA. Electronic address: AMaudsley@miami.edu.
Andrew A
AA
Maudsley
Department of Radiology, University of Miami, Miami, FL, USA.
Mohammed Z
MZ
Goryawala
Department of Radiology, University of Miami, Miami, FL, USA.
Sulaiman
S
Sheriff
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001831:Body Temperature; D001921:Brain / Q000378:metabolism*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D013817:Thermography; D055815:Young Adult
D001224:Aspartic Acid; C000179:N-acetylaspartate
Aging; Brain temperature; Gender; MR spectroscopic imaging; Tissue susceptibility
PLoS One. 2012;7(4):e35607
22539984
MAGMA. 2016 Dec;29(6):811-822
27260664
Int J Nurs Stud. 2009 May;46(5):661-8
19128801
Magn Reson Med. 2007 Jan;57(1):59-66
17139620
J Cereb Blood Flow Metab. 1997 Apr;17(4):363-9
9143218
Magn Reson Med. 2011 Sep;66(3):609-18
21394775
Hum Brain Mapp. 2012 Jul;33(7):1503-11
21674690
Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13558-63
19628691
Magn Reson Med. 2016 Apr;75(4):1764-70
25982125
Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11796-801
17586684
NMR Biomed. 2013 Feb;26(2):213-23
22961726
Hum Brain Mapp. 2010 Mar;31(3):378-90
19662658
J Neurol Neurosurg Psychiatry. 1998 Jun;64(6):792-4
9647313
Magn Reson Med. 1998 Dec;40(6):822-31
9840826
J Neurochem. 1995 Mar;64(3):1224-30
7861155
Magn Reson Med. 2001 Dec;46(6):1072-8
11746571
Ann Neurol. 2006 Oct;60(4):438-46
16972284
Neuroimage. 2009 Jun;46(2):486-99
19385016
J Magn Reson. 1997 Mar;125(1):166-70
9245375
Anal Chim Acta. 2014 Aug 1;838:1-12
25064237
Magn Reson Med. 2005 Feb;53(2):465-9
15678549
Altern Med Rev. 2006 Dec;11(4):278-93
17176167
Hum Brain Mapp. 2014 Jun;35(6):2698-713
24038837
IEEE Trans Med Imaging. 2001 Jan;20(1):45-57
11293691
Epilepsy Res. 2010 Feb;88(2-3):127-38
19926450
J Magn Reson. 2011 Sep;212(1):55-63
21752679
J Appl Physiol (1985). 2006 Nov;101(5):1481-8
16840581
Magn Reson Med. 2009 Mar;61(3):548-59
19111009
J Neurotrauma. 2010 Mar;27(3):483-96
20201668
NMR Biomed. 2011 Aug;24(7):865-72
21834009
Surg Neurol. 1995 Jan;43(1):91-5
7701435
J Magn Reson Imaging. 2010 Apr;31(4):807-14
20373423
NMR Biomed. 2010 Apr;23(3):251-6
19777506
Magn Reson Med. 1995 Jun;33(6):862-7
7651127
NMR Biomed. 2001 Apr;14(2):140-8
11320539
Magn Reson Med Sci. 2003 Apr 1;2(1):17-22
16210815
Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5130-5
20202922
Magn Reson Med. 2015 Nov;74(5):1209-20
25354190
Neuroimage. 2012 Jan 16;59(2):1413-9
21893208
Magn Reson Imaging. 2003 Feb;21(2):113-20
12670597
Brain Res. 1969 Dec;16(2):417-40
4311724
IEEE Trans Med Imaging. 1998 Jun;17(3):463-8
9735909
NMR Biomed. 2014 Aug;27(8):863-9
24865447
Front Neurosci. 2014 Oct 08;8:307
25339859
Magn Reson Med. 2008 Sep;60(3):536-41
18727039