Data on combination effect of PEG-coated gold nanoparticles and non-thermal plasma inhibit growth of solid tumors.
Highly resistant tumor cells are hard to treat at low doses of plasma. Therefore, researchers have gained more attention to development of enhancers for plasma therapy. Some enhancers could improve the efficacy of plasma towards selectivity of cancer cells damage. In this dataset, we report the application of low doses of PEG-coated gold nanoparticles with addition of plasma treatment. This data consists of the effect of PEG-coated GNP and cold plasma on two solid tumor cell lines T98G glioblastoma and A549 lung adenocarcinoma. Cell proliferation, frequency of cancer stem cell population studies by this co-treatment was reported. Finally, we included in this dataset the effect of co-treatment in vivo, using tumor xenograft nude mice models. The data supplied in this article supports the accompanying publication "Low doses of PEG-coated gold nanoparticles sensitize solid tumors to cold plasma by blocking the PI3K/AKT-driven signaling axis to suppress cellular transformation by inhibiting growth and EMT" (N. K. Kaushik, N. Kaushik, K. C. Yoo, N Uddin, J. S. Kim, S. J. Lee et al., 2016) [1].
Plasma Bioscience Research Center / Department of Electrical and Biological Physics, Kwangwoon University, Seoul, 139-701 Korea.
Nagendra Kumar
NK
Kaushik
Plasma Bioscience Research Center / Department of Electrical and Biological Physics, Kwangwoon University, Seoul, 139-701 Korea; Department of Life Science, Research Institute for Natural Sciences, Hanyang University, Seoul, 133-791 Korea.
Neha
N
Kaushik
Department of Life Science, Research Institute for Natural Sciences, Hanyang University, Seoul, 133-791 Korea.
Ki Chun
KC
Yoo
Department of Life Science, Research Institute for Natural Sciences, Hanyang University, Seoul, 133-791 Korea.
Nizam
N
Uddin
Plasma Bioscience Research Center / Department of Electrical and Biological Physics, Kwangwoon University, Seoul, 139-701 Korea.
Ju Sung
JS
Kim
Department of Life Science, Research Institute for Natural Sciences, Hanyang University, Seoul, 133-791 Korea.
Su Jae
SJ
Lee
Plasma Bioscience Research Center / Department of Electrical and Biological Physics, Kwangwoon University, Seoul, 139-701 Korea.
Eun Ha
EH
Choi
Cancer; DBD plasma; Gold nanoparticles; Non-thermal plasma; Solid tumor; in vivo study
Sci Rep. 2015 Feb 26;5:8587
25715710
Sci Rep. 2015 Mar 04;5:8726
25735798
Biomaterials. 2016 May;87:118-30
26921841