Updates on antibody-mediated rejection in intestinal transplantation.
Antibody-mediated rejection (ABMR) has increasingly emerged as an important cause of allograft loss after intestinal transplantation (ITx). Compelling evidence indicates that donor-specific antibodies can mediate and promote acute and chronic rejection after ITx. However, diagnostic criteria for ABMR after ITx have not been established yet and the mechanisms of antibody-mediated graft injury are not well-known. Effective approaches to prevent and treat ABMR are required to improve long-term outcomes of intestine recipients. Clearly, ABMR after ITx has become an important area for research and clinical investigation.
Guo-Sheng Wu, Division of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases, the Fourth Military Medical University, Xi'an 710032, Shannxi Province, China.
Guo-Sheng
GS
Wu
Antibody-mediated rejection; C4d deposition; Chronic rejection; Donor-specific antibodies; Hyperacute rejection; Intestinal transplantation; Outcomes
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