T-cell immunometabolism against cancer.
T cells play critical roles in host defenses against cancer. External signals prompt activation of naïve T cells, triggering modulation of their immune functions. Emerging evidence reveals that distinct metabolic changes impact the immune functions of naïve and effector T cells, including CD4+and CD8+T cells. Since T cells appear to be key players in tumor progression, it is important to elucidate whether and how T-cell metabolic reprogramming might alter their impact on cancer progression. Here we briefly review the available knowledge regarding T cells in relation to cancer, focusing on the metabolic reprogramming of T cells and how this influences tumor progression. Emerging insights in this field are improving our understanding of the functional role of T-cell metabolic reprogramming in cancer. Further research could provide a critical foundation for new treatments targeting cancer metabolism.
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: luckysjiang@caltech.edu.
Shuai
S
Jiang
Department of Cancer Biology, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA. Electronic address: wyan@coh.org.
Wei
W
Yan
D000818:Animals; D019496:Cancer Vaccines / Q000627:therapeutic use; D065150:Cellular Reprogramming; D004734:Energy Metabolism; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D008213:Lymphocyte Activation; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology / Q000378:metabolism*; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D010641:Phenotype; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D019139:Tumor Escape
D019496:Cancer Vaccines
Cancer; Immunometabolism; Immunotherapy; T cell