It's Your Game…Keep It Real in South Carolina: A Group Randomized Trial Evaluating the Replication of an Evidence-Based Adolescent Pregnancy and Sexually Transmitted Infection Prevention Program.
OBJECTIVE
To evaluate the effectiveness of an evidence-based HIV/sexually transmitted infection (STI)/pregnancy prevention program for middle schools implemented by school staff in South Carolina.


METHODS
Twenty-four schools, representing 3143 youths, participated in a randomized trial from 2011 to 2014. Students completed surveys before programming (fall of seventh grade), after completing the 2-year It's Your Game…Keep It Real program (spring of eighth grade), and 1-year postprogram (spring of ninth grade).


RESULTS
There was no statistically significant effect on initiation of vaginal sex between baseline and eighth grade. Significantly fewer students in the comparison condition reported initiating sex at ninth grade, relative to the intervention condition. No group differences existed on other behavioral outcomes that addressed sexual activity in the past 3 months at ninth grade. Seven of 26 psychosocial outcomes (3 knowledge, 1 attitude, 1 self-efficacy, 2 personal limits) were positively affected at eighth grade; 4 remained significant at ninth grade.


CONCLUSIONS
The original studies' behavioral effects were not replicated in this population, possibly as a result of this being an effectiveness trial instead of an efficacy trial, counterfactual exposure design issues, or postprogram exposure to evidence-based programming.
Susan C. Potter, Karin K. Coyle, and Jill R. Glassman are with ETR, Scotts Valley, CA. Sarah Kershner and Mary S. Prince are with the South Carolina Campaign to Prevent Teen Pregnancy, Columbia.
Susan C
SC
Potter
Susan C. Potter, Karin K. Coyle, and Jill R. Glassman are with ETR, Scotts Valley, CA. Sarah Kershner and Mary S. Prince are with the South Carolina Campaign to Prevent Teen Pregnancy, Columbia.
Karin K
KK
Coyle
Susan C. Potter, Karin K. Coyle, and Jill R. Glassman are with ETR, Scotts Valley, CA. Sarah Kershner and Mary S. Prince are with the South Carolina Campaign to Prevent Teen Pregnancy, Columbia.
Jill R
JR
Glassman
Susan C. Potter, Karin K. Coyle, and Jill R. Glassman are with ETR, Scotts Valley, CA. Sarah Kershner and Mary S. Prince are with the South Carolina Campaign to Prevent Teen Pregnancy, Columbia.
Sarah
S
Kershner
Susan C. Potter, Karin K. Coyle, and Jill R. Glassman are with ETR, Scotts Valley, CA. Sarah Kershner and Mary S. Prince are with the South Carolina Campaign to Prevent Teen Pregnancy, Columbia.
Mary S
MS
Prince
AIDS Res Treat. 2012;2012:298494
22811892
J Adolesc Health. 2014 Mar;54(3 Suppl):S3-9
24560074
Natl Vital Stat Rep. 2014 Aug 20;63(4):1-34
25142408
J Adolesc Health. 2012 Mar;50(3):279-88
22325134
Public Health Rep. 2001;116 Suppl 1:82-93
11889277
J Adolesc Health. 2014 May;54(5):499-507
24525227
J Adolesc Health. 2010 Feb;46(2):169-79
20113923
J Adolesc Health. 2014 Feb;54(2):151-9
24445180
Am J Public Health. 2003 Aug;93(8):1261-7
12893608
BMJ. 1995 Jan 21;310(6973):170
7833759
Natl Vital Stat Rep. 2015 Jan 15;64(1):1-65
25603115
J Adolesc Health. 2015 May;56(5):515-21
25739520