Stressful life events and psychosocial correlates of pediatric inflammatory bowel disease activity.
OBJECTIVE
To investigate the association of psychiatric and psychosocial correlates with inflammatory bowel disease (IBD) activity in children and adolescents.


METHODS
A total of 85 pediatric IBD patients (in remission or active state of the disease) and their parents completed a series of questionnaires and semi-structured interviews measuring life events, depression, anxiety, family dysfunction, and parent mental health. Differences between the remission and the IBD active group and the association of any significant variable with the disease activity state were examined.


RESULTS
Parents of children being in active state of the disease reported more life events (P = 0.005) and stressful life events (P = 0.048) during the past year and more mental health symptoms (P < 0.001), while the children themselves reported higher levels of anxiety symptoms (P = 0.017) compared to the remission group. In the logistic regression multivariate analysis, the only predictor which had a significant positive effect on the probability of the patients being in active state was parent mental health symptoms (OR = 4.8; 95%CI: 1.2-25.8).


CONCLUSIONS
Life events, child anxiety and parent mental health symptoms may be important correlates of pediatric IBD activity and targets of thorough assessment and treatment.
George Giannakopoulos, Sophia Korlou, Vassiliki Hantzara, Magda Liakopoulou, Dimitris C Anagnostopoulos, Department of Child Psychiatry, National and Kapodistrian University of Athens, School of Medicine, Aghia Sophia Children's Hospital, 11527 Athens, Greece.
George
G
Giannakopoulos
George Giannakopoulos, Sophia Korlou, Vassiliki Hantzara, Magda Liakopoulou, Dimitris C Anagnostopoulos, Department of Child Psychiatry, National and Kapodistrian University of Athens, School of Medicine, Aghia Sophia Children's Hospital, 11527 Athens, Greece.
George
G
Chouliaras
George Giannakopoulos, Sophia Korlou, Vassiliki Hantzara, Magda Liakopoulou, Dimitris C Anagnostopoulos, Department of Child Psychiatry, National and Kapodistrian University of Athens, School of Medicine, Aghia Sophia Children's Hospital, 11527 Athens, Greece.
Daphne
D
Margoni
George Giannakopoulos, Sophia Korlou, Vassiliki Hantzara, Magda Liakopoulou, Dimitris C Anagnostopoulos, Department of Child Psychiatry, National and Kapodistrian University of Athens, School of Medicine, Aghia Sophia Children's Hospital, 11527 Athens, Greece.
Sophia
S
Korlou
George Giannakopoulos, Sophia Korlou, Vassiliki Hantzara, Magda Liakopoulou, Dimitris C Anagnostopoulos, Department of Child Psychiatry, National and Kapodistrian University of Athens, School of Medicine, Aghia Sophia Children's Hospital, 11527 Athens, Greece.
Vassiliki
V
Hantzara
George Giannakopoulos, Sophia Korlou, Vassiliki Hantzara, Magda Liakopoulou, Dimitris C Anagnostopoulos, Department of Child Psychiatry, National and Kapodistrian University of Athens, School of Medicine, Aghia Sophia Children's Hospital, 11527 Athens, Greece.
Ioanna
I
Panayotou
George Giannakopoulos, Sophia Korlou, Vassiliki Hantzara, Magda Liakopoulou, Dimitris C Anagnostopoulos, Department of Child Psychiatry, National and Kapodistrian University of Athens, School of Medicine, Aghia Sophia Children's Hospital, 11527 Athens, Greece.
Eleftheria
E
Roma
George Giannakopoulos, Sophia Korlou, Vassiliki Hantzara, Magda Liakopoulou, Dimitris C Anagnostopoulos, Department of Child Psychiatry, National and Kapodistrian University of Athens, School of Medicine, Aghia Sophia Children's Hospital, 11527 Athens, Greece.
Magda
M
Liakopoulou
George Giannakopoulos, Sophia Korlou, Vassiliki Hantzara, Magda Liakopoulou, Dimitris C Anagnostopoulos, Department of Child Psychiatry, National and Kapodistrian University of Athens, School of Medicine, Aghia Sophia Children's Hospital, 11527 Athens, Greece.
Dimitris C
DC
Anagnostopoulos
Anxiety; Children and adolescents; Depression; Inflammatory bowel disease; Stressful events
J Am Acad Dermatol. 1992 Aug;27(2 Pt 1):178-81
1430353
Curr Mol Med. 2008 Jun;8(4):247-52
18537632
J Pediatr Gastroenterol Nutr. 2007 May;44(5):653-74
17460505
J Pediatr Gastroenterol Nutr. 2005 Jul;41(1):1-7
15990620
J Pediatr Gastroenterol Nutr. 2005 Oct;41(4):416-21
16205508
Scand J Gastroenterol. 1987 Oct;22(8):1009-24
3685876
Curr Psychiatry Rep. 2010 Jun;12(3):222-8
20425284
J Pediatr Psychol. 2009 Mar;34(2):129-36
18577543
Am J Gastroenterol. 2005 Jun;100(6):1386-92
15929775
J Am Acad Child Adolesc Psychiatry. 1990 Jul;29(4):608-10
2387796
J Psychosom Res. 1972 Feb;16(1):7-18
5058990
J Psychosom Res. 2002 Mar;52(3):173-9
11897236
J Pediatr Gastroenterol Nutr. 2011 Mar;52(3):295-9
21297508
J Pediatr Gastroenterol Nutr. 2004 Oct;39(4):395-403
15448431
Psychopharmacol Bull. 1985;21(4):995-8
4089116
J Am Acad Child Adolesc Psychiatry. 1987 Sep;26(5):774-81
3667511
J Abnorm Child Psychol. 1997 Feb;25(1):15-20
9093896
Ital J Gastroenterol Hepatol. 1998 Jun;30(3):247-51
9759588
J Pediatr Psychol. 2006 Apr;31(3):281-5
15802606
J Child Psychol Psychiatry. 1982 Jan;23(1):33-42
7061643
Curr Opin Pediatr. 2007 Oct;19(5):548-52
17885473
J Am Acad Child Adolesc Psychiatry. 2002 Jun;41(6):634-59
12049439
Inflamm Bowel Dis. 2009 Aug;15(8):1218-23
19161178
Br J Psychiatry. 1987 Aug;151:179-84
3690107
J Am Acad Child Adolesc Psychiatry. 1997 Apr;36(4):474-80
9100421
Qual Life Res. 2000 Mar;9(2):185-93
10983482
Inflamm Bowel Dis. 2008 Sep;14(9):1281-6
18512247
J Pediatr Psychol. 1997 Oct;22(5):723-38
9383932
Inflamm Bowel Dis. 2011 Jan;17(1):423-39
20564651
J Abnorm Child Psychol. 1978 Jun;6(2):271-80
670592