Association of single nucleotide polymorphism with arsenic-induced skin lesions and genetic damage in exposed population of West Bengal, India.
Long term consumption of arsenic contaminated water causes a number of dermatological and non-dermatological health problems and cancer. In a Genome Wide Association Study (GWAS) on Bangladesh population, a significant association of asingle nucleotide polymorphism (SNP) in the C10orf32 region (rs 9527; G>A) with urinary metabolites and arsenic induced skin lesions was reported. This study aims to evaluate the association of the C10orf32 G to A polymorphism (rs9527), concerned with As3MT read-through transcription, with the development of arsenic induced skin lesions in the arsenic exposed individuals of West Bengal, India. A total of 157 individuals with characteristic skin lesions (cases) and 158 individuals without any skin lesion (controls) were recruited for this study. The G>A polymorphism (rs9527) having at least one minor allele 'A' was found to be significantly higher in cases compared to controls, implying increased risk toward the development of skin lesions. The risk genotype was also found to be significantly associated with cytogenetic damage as measured by chromosomal aberrations and micronuclei formation in lymphocytes. Hence, it can be concluded that G>A change in the C10orf32 region plays an important role in arsenic induced toxicity and susceptibility.
Molecular Genetics Division, Indian Institute of Chemical Biology, Kolkata-700032, India.
Nandana
N
Das
Department of Environmental Science, University of Calcutta, Kolkata-700019, India.
Allan
A
Giri
Molecular Genetics Division, Indian Institute of Chemical Biology, Kolkata-700032, India.
Sayan
S
Chakraborty
Department of Environmental Science, University of Calcutta, Kolkata-700019, India. Electronic address: 777.pritha@gmail.com.
Pritha
P
Bhattacharjee
D000328:Adult; D020261:Arsenic Poisoning / Q000150:complications* / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D002869:Chromosome Aberrations; D003173:Complement C1s / Q000172:deficiency; D003598:Cytoskeletal Proteins; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D000081208:Hereditary Complement Deficiency Diseases; D006801:Humans; D007153:Immunologic Deficiency Syndromes; D007194:India / Q000453:epidemiology; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012871:Skin Diseases / Q000139:chemically induced / Q000453:epidemiology / Q000235:genetics*
C000619378:BORCS7 protein, human; D002352:Carrier Proteins; D003598:Cytoskeletal Proteins; D003173:Complement C1s
Arsenic toxicity; Drinking water; Genetic damage; Single nucleotide polymorphism; Skin lesions