Indium triflate promoted one-pot multicomponent synthesis of structurally diverse 3-amino-imidazo[1,2-a]pyridines.
An efficient, mild, and expeditious synthetic protocol has been developed for the synthesis of structurally diverse 3-amino-imidazo[1,2-a]pyridines, involving a three-component, one-pot cyclocondensation reaction of 2-aminobenzothiazole/2-aminoazines, ethyl isocyanoacetate/tert-butyl isocyanides, and pyrazole-3(4)-carbaldehyde/substituted aromatic carbonyl compounds in 45 min. using In(OTf)[Formula: see text] as a catalyst in toluene. Mild reaction conditions, high atom economy, operational simplicity, short reaction time, and structural diversity with high product conversion are among the advantages of the present synthetic protocol.
Department of Chemistry, Manipal University Jaipur, VPO-Dehmi Kalan, Teshil-Sanganer, Off Jaipur Ajmer Expressway, Jaipur, Rajasthan, 303007, India.
Suman
S
Swami
Department of Chemistry, Manipal University Jaipur, VPO-Dehmi Kalan, Teshil-Sanganer, Off Jaipur Ajmer Expressway, Jaipur, Rajasthan, 303007, India.
Arunava
A
Agarwala
Department of Chemistry, Manipal University Jaipur, VPO-Dehmi Kalan, Teshil-Sanganer, Off Jaipur Ajmer Expressway, Jaipur, Rajasthan, 303007, India. chem.rahul@gmail.com.
Rahul
R
Shrivastava
D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D055772:Green Chemistry Technology; D007093:Imidazoles / Q000737:chemistry*; D008698:Mesylates / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D007093:Imidazoles; D008698:Mesylates; D011725:Pyridines; D014867:Water; C012077:trifluoromethanesulfonic acid
Imidazo[1, 2-a]pyridine; Indium triflate; Isocyanide; Lewis acid; MCRs
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