Dehydrosulfurative C-N Cross-Coupling and Concomitant Oxidative Dehydrogenation for One-Step Synthesis of 2-Aryl(alkyl)aminopyrimidines from 3,4-Dihydropyrimidin-1H-2-thiones.
A method for the synthesis of 2-aryl(alkyl)aminopyrimidines from readily available 3,4-dihydropyrimidin-1H-2-thiones (DHPMs) via dehydrosulfurative C-N cross-coupling and concomitant oxidative dehydrogenation under a Pd/Cu catalytic system is described. This reaction protocol provides unprecedented diversity of fully substituted 2-aryl(alkyl)aminopyrimidines in a single step from a wide range of DHPMs and amine coupling partners.
Department of Chemistry, College of Natural Sciences, Chungnam National University , Dajeon 305-706, Korea.
Nguyen Huu Trong
NH
Phan
Department of Chemistry, College of Natural Sciences, Chungnam National University , Dajeon 305-706, Korea.
Hyeji
H
Kim
Yonsung Fine Chemicals R&D Center , Suwon 443-380 Korea.
Hyunik
H
Shin
Department of Chemistry, KAIST , Daejeon 305-701 Korea.
Hee-Seung
HS
Lee
Department of Chemistry, College of Natural Sciences, Chungnam National University , Dajeon 305-706, Korea.
Jeong-Hun
JH
Sohn