Effect of angiotensin II type 1 receptor blockade on kidney ischemia/reperfusion; a gender-related difference.
BACKGROUND
Renal ischemia/reperfusion (I/R) injury may be related to activity of reninangiotensin system (RAS), which is gender-related. In this study, it was attempted to compare the effect of angiotensin II (Ang II) receptor type 1 (AT1R) blockade; losartan in I/R injury in male and female rats.


METHODS
Male and female Wistar rats were assigned as sham surgery, control I/R groups treated with vehicle, and case I/R groups treated with losartan (30 mg/kg). Vehicle and losartan were given 2 hours before bilateral kidney ischemia induced by clamping renal arteries for 45 minutes followed by 24 hours of renal reperfusion.


RESULTS
The I/R injury significantly increased the serum levels of blood urea nitrogen (BUN) and creatinine (Cr), and kidney tissue damage score in both genders. However, losartan decreased these values in female rats significantly (P < 0.05). This was not observed in male rats.


CONCLUSIONS
Losartan protects the kidney from I/R injury in female but not in male rats possibly because of gender-related difference of RAS.
Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Fatemeh
F
Moslemi
Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Pegah
P
Taheri
Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Mahdis
M
Azimipoor
Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Sina
S
Ramtin
Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Mostafa
M
Hashemianfar
Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Ali
A
Momeni-Ashjerdi
Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Fatemeh
F
Eshraghi-Jazi
Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Ardeshir
A
Talebi
Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Hamid
H
Nasri
Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ; Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran ; IsfahanMN Institute of Basic & Applied Sciences Research, Isfahan Iran.
Mehdi
M
Nematbakhsh
Acute kidney injury; Gender; Ischemia reperfusion injury; Losartan
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