Synthesis of amino ester-embedded benzimidazoles: a one-pot sequential protocol under metal-free neutral conditions.
A one-pot three-component protocol has been developed for the synthesis of amino ester-embedded benzimidazoles under metal-free neutral conditions. Sequentially, the methodology involves coupling of an amino ester with 1-fluoro-2-nitrobenzene, reduction of the coupled nitroarene by sodium dithionite, and cyclization of the corresponding diamine with an aldehyde.
Department of Chemistry, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India.|Department of Chemistry, Victoria Institution (College), 78B, A.P.C. Road, Kolkata, 700009, India.
Priyabrata
P
Roy
Department of Chemistry, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India.
Chandan
C
Bodhak
Department of Chemistry, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India. animesh_in2001@yahoo.co.in.
Animesh
A
Pramanik
D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D004952:Esters / Q000737:chemistry*
D001562:Benzimidazoles; D004952:Esters
Amino acids; Benzimidazoles; Cyclization; MCRs; Reduction; Substitution
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