Case of a tumor comprising gastric cancer and duodenal neuroendocrine tumor.
The present report describes a rare case of a tumor composed of early gastric cancer and a duodenal neuroendocrine tumor (NET). A 78-year-old woman underwent esophagogastroduodenoscopy at a local institution for screening of the upper gastrointestinal tract which revealed a protruded tumor through the pyloric ring from the pyloric antrum. The tumor was too large to treat at the facility; consequently, she was referred to our hospital for further management. Esophagogastroduodenoscopy with tumor biopsy of the lesion revealed the diagnosis of early gastric cancer. Endoscopic submucosal dissection was performed with sufficient free margins in both vertical and horizontal directions. Histopathological findings showed NET confined to the submucosal layer and covered by well-differentiated adenocarcinoma. Immunohistochemical stainings showed that the two lesions existed continuously. While the possibility of a collision cancer was considered, it was suggested that the two lesions existed continuously. Finally, the tumor was diagnosed as gastric cancer composed of duodenal NET G1, with a lymphatic invasion of NET component.
Hiroaki Kaneko, Yasuaki Ishii, Soichiro Sue, Haruo Miwa, Tomohiko Sasaki, Toshihide Tamura, Masaaki Kondo, Shin Maeda, Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Hiroaki
H
Kaneko
Hiroaki Kaneko, Yasuaki Ishii, Soichiro Sue, Haruo Miwa, Tomohiko Sasaki, Toshihide Tamura, Masaaki Kondo, Shin Maeda, Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Akio
A
Miyake
Hiroaki Kaneko, Yasuaki Ishii, Soichiro Sue, Haruo Miwa, Tomohiko Sasaki, Toshihide Tamura, Masaaki Kondo, Shin Maeda, Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Yasuaki
Y
Ishii
Hiroaki Kaneko, Yasuaki Ishii, Soichiro Sue, Haruo Miwa, Tomohiko Sasaki, Toshihide Tamura, Masaaki Kondo, Shin Maeda, Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Soichiro
S
Sue
Hiroaki Kaneko, Yasuaki Ishii, Soichiro Sue, Haruo Miwa, Tomohiko Sasaki, Toshihide Tamura, Masaaki Kondo, Shin Maeda, Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Haruo
H
Miwa
Hiroaki Kaneko, Yasuaki Ishii, Soichiro Sue, Haruo Miwa, Tomohiko Sasaki, Toshihide Tamura, Masaaki Kondo, Shin Maeda, Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Tomohiko
T
Sasaki
Hiroaki Kaneko, Yasuaki Ishii, Soichiro Sue, Haruo Miwa, Tomohiko Sasaki, Toshihide Tamura, Masaaki Kondo, Shin Maeda, Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Toshihide
T
Tamura
Hiroaki Kaneko, Yasuaki Ishii, Soichiro Sue, Haruo Miwa, Tomohiko Sasaki, Toshihide Tamura, Masaaki Kondo, Shin Maeda, Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Masaaki
M
Kondo
Hiroaki Kaneko, Yasuaki Ishii, Soichiro Sue, Haruo Miwa, Tomohiko Sasaki, Toshihide Tamura, Masaaki Kondo, Shin Maeda, Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Shin
S
Maeda
D000230:Adenocarcinoma / Q000473:pathology; D000368:Aged; D001706:Biopsy; D004379:Duodenal Neoplasms / Q000150:complications / Q000175:diagnosis*; D004386:Duodenum / Q000473:pathology; D016145:Endoscopy, Digestive System; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D018358:Neuroendocrine Tumors / Q000150:complications / Q000175:diagnosis*; D013274:Stomach Neoplasms / Q000150:complications / Q000175:diagnosis*
Composite- type tumor; Duodenum; Endoscopic submucosal dissection; Gastric cancer; Neuroendocrine tumor
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