The Predictive Value of Tumor Size, Volume, and Markers During Radiation Therapy in Patients With Cervical Cancer.
We investigated the prognostic significance of changes in primary tumor volume and serum squamous cell carcinoma antigen (SCC-ag) levels during radiation therapy (RT) in patients with cervical cancer.



We conducted a review of 40 patients treated with RT. All patients received external beam RT and intracavitary brachytherapy. The primary tumor volume and squamous cell carcinoma antigen levels were measured pre-RT and mid-RT. Overall survival (OS) and progression free survival (PFS) were estimated, and possible prognostic factors for survival were analyzed.



The correlation coefficient between primary tumor volume reduction rate (pTVRR) and serum squamous cell carcinoma antigen reduction rate in all patients was 0.550 (P < 0.001). In univariate analysis, stage more than II (P <0.001), pre-RT pTV of 55 cm or more (P = 0.05), mid-RT tumor size of 4 cm or more (P = 0.004), and pTVRR of 90% or less (P = 0.031) were significant unfavorable prognostic factors for PFS, whereas stage (P = 0.009) was the only significant prognostic factor for OS. Multivariable analysis revealed that none of these factors were independently associated with PFS or OS.



There was a significant correlation between pTVRR and squamous cell carcinoma antigen reduction rate. Our findings indicate that the tumor parameters such as pre-RT pTV, mid-RT tumor size, and pTVRR are associated with PFS in women with cervical cancer.
*Department of Radiation Oncology, Gachon University of Medical and Science; †Department of Radiation Oncology, Inha University Hospital, Inha University School of Medicine; and Departments of ‡Obstetrics and Gynecology, §Medicine, and ‖Radiology, Gachon University Gil Medical Center, Incheon, Korea.
Kyu Chan
KC
Lee
Hun Jung
HJ
Kim
KiHoon
K
Sung
Young Eun
YE
Choi
Seok Ho
SH
Lee
Soyi
S
Lim
Kwang Beom
KB
Lee
Jin Woo
JW
Shin
Chan Yong
CY
Park
Young Saing
YS
Kim
Sun Jin
SJ
Sym
Young Sup
YS
Shim
Seung Joon
SJ
Choi
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D001918:Brachytherapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D015843:Serpins / Q000097:blood*; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy*
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D015843:Serpins; C051072:squamous cell carcinoma-related antigen