Maternal Serum and Cervicovaginal IL-6 in Patients with Symptoms of Preterm Labor.
BACKGROUND
Preterm birth is a common problem in obstetrics.


OBJECTIVE
To measure maternal serum interlukin-6 in mothers with preterm uterine contractions and compare it with cervicovaginal interlukin-6 in the same women.


METHODS
In this cross-sectional study, we measured interlukin-6 in the sera and cervicovaginal fluids of 86 women with preterm uterine contractions. All participants had an intact membrane. Interlukin-6 was measured by using ELISA method. Statistical analysis was done using U-Mann Whitney, Chi-Square and Kendall's tests.


RESULTS
The mean and median (Quartile25, Quartile75) of interlukin-6 in cervicovaginal fluid was higher than maternal serum interlukin-6. There was a statically significant difference in the median of interlukin-6 in sera and cervicovaginal fluid (P<0.0001). There was no significant correlation between serum and cervicovaginal interlukin-6 (r=0.048, p=0.548).


CONCLUSIONS
We found no relationship between serum interlukin-6 and preterm labor and the maternal serum Interlukin-6 does not seem to be a suitable biomarker for predicting preterm delivery.
Department of Midwifery, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran. e-mail: p_k_hn@yahoo.com.
Parisa
P
Yavari Kia
Behzad
B
Baradaran
Mahnaz
M
Shahnazi
Mohammad
M
Asghari Jafarabadi
Vahid
V
Khaze
Shakiba
S
Pourasad Shahrak
D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism*; D002584:Cervix Uteri / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D007492:Iran; D007752:Obstetric Labor, Premature / Q000276:immunology*; D011247:Pregnancy; D014621:Vagina / Q000378:metabolism*
D015415:Biomarkers; D001798:Blood Proteins; D015850:Interleukin-6