Differences in the Epidemiology of Childhood Infections with Avian Influenza A H7N9 and H5N1 Viruses.
The difference between childhood infections with avian influenza viruses A(H5N1) and A(H7N9) remains an unresolved but critically important question. We compared the epidemiological characteristics of 244 H5N1 and 41 H7N9 childhood cases (<15 years old), as well as the childhood cluster cases of the two viruses. Our findings revealed a higher proportion of H5N1 than H7N9 childhood infections (31.1% vs. 6.4%, p = 0.000). However, the two groups did not differ significantly in age (median age: 5.0 vs. 5.5 y, p = 0.0651). The proportion of clustered cases was significantly greater among children infected with H5N1 than among children infected with H7N9 [46.7% (71/152) vs. 23.6% (13/55), p = 0.005], and most of the childhood cases were identified as secondary cases [46.4% (45/97) vs. 33.3% (10/30), p = 0.000]. Mild status accounted for 79.49% and 22.66%, severe status for 17.95% and 2.34%, and fatal cases for 2.56% and 75.00% of the H7N9 and H5N1 childhood infection cases (all p<0.05), respectively. The fatality rates for the total, index and secondary childhood cluster cases were 52.86% (37/70), 88.5% (23/26) and 33.33% (15/45), respectively, in the H5N1 group, whereas no fatal H7N9 childhood cluster cases were identified. In conclusion, lower severity and greater transmission were found in the H7N9 childhood cases than in the H5N1 childhood cases.
Department of Endocrinology, The 421 Hospital of Chinese People's Liberation Army, Guangzhou, China.
Jianping
J
Sha
School of Public Health, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Wei
W
Dong
Department of Infectious Diseases, Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, China.
Shelan
S
Liu
Department of Senior Cadres, The 421 Hospital of Chinese People's Liberation Army, Guangzhou, China.
Xiaowen
X
Chen
National Research Center for Wildlife Born Diseases, Key Lab of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Na
N
Zhao
School of Public Health, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Mengyun
M
Luo
School of Public Health, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Yuanyuan
Y
Dong
School of Public Health, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Zhiruo
http://orcid.org/0000-0002-3788-3703
Z
Zhang
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D006801:Humans; D007223:Infant; D053124:Influenza A Virus, H5N1 Subtype; D064766:Influenza A Virus, H7N9 Subtype; D007251:Influenza, Human / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D012737:Sex Factors; D055815:Young Adult
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