Optic nerve head slope-based quantitative parameters for identifying open-angle glaucoma on SPECTRALIS OCT images.
OBJECTIVE
To investigate monitoring slope-based features of the optic nerve head (ONH) cup as open-angle glaucoma (OAG) occurs.


METHODS
A dataset of 46 retrospective OCT cases was acquired from the SPECTRALIS Heidelberg Engineering OCT device. A set of five parameters, which are based on the ONH cup-incline, are measured on the OAG and normal subjects in the dataset. Then, three new ONH cup-shape indices were deduced. The ONH cup-incline parameters and ONH cup-shape indices are analyzed to estimate their clinical value.


RESULTS
The statistical difference between measurements on normal and glaucoma eyes was remarkably significant for all of the analyzed parameters and indices (p value < 0.001).


CONCLUSIONS
The geometric shape of the ONH cup can be transferred to numerical parameters and indices. The proposed ONH cup-incline parameters and ONH cup-shape indices have shown suggestive clinical value to identify the development of OAG. As OAG appears, the top ONH cup-incline parameters decrease while the bottom ONH cup-incline parameters increase. The ONH cup-shape indices suggest capability to discriminate OAG from normal eyes.
Medical Imaging Department, Faculty of Allied Health Sciences, The Hashemite University, Zarqa, Jordan.
Abdel-Razzak M
AM
Al-Hinnawi
Biomedical Engineering Department, Faculty of Engineering, The Hashemite University, P.O. Box 150459, Zarqa, 13115, Jordan. b.naami@hu.edu.jo.
Bassam O
BO
Al-Naami
Ophthalmology Department, Faculty of Medicine, The Hashemite University, Zarqa, Jordan.
Motasem M
MM
Al-Latayfeh
D005260:Female; D005902:Glaucoma, Open-Angle / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis* / Q000209:etiology; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*
Image feature analysis; Open-angle glaucoma; Optical coherence tomography; Optical nerve head
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