Lack of Postprandial Peak in Brain-Derived Neurotrophic Factor in Adults with Prader-Willi Syndrome.
BACKGROUND
Prader-Willi syndrome (PWS) is characterized by severe hyperphagia. Brain-derived neurotrophic factor (BDNF) and leptin are reciprocally involved in energy homeostasis.


OBJECTIVE
To analyze the role of BDNF and leptin in satiety in genetic subtypes of PWS.


METHODS
Experimental study.


METHODS
University hospital.


METHODS
90 adults: 30 PWS patients; 30 age-sex-BMI-matched obese controls; and 30 age-sex-matched lean controls.


METHODS
Subjects ingested a liquid meal after fasting ≥10 hours.


METHODS
Leptin and BDNF levels in plasma extracted before ingestion and 30', 60', and 120' after ingestion. Hunger, measured on a 100-point visual analogue scale before ingestion and 60' and 120' after ingestion.


RESULTS
Fasting BDNF levels were lower in PWS than in controls (p = 0.05). Postprandially, PWS patients showed only a truncated early peak in BDNF, and their BDNF levels at 60' and 120' were lower compared with lean controls (p<0.05). Leptin was higher in PWS patients than in controls at all time points (p<0.001). PWS patients were hungrier than controls before and after eating. The probability of being hungry was associated with baseline BDNF levels: every 50-unit increment in BDNF decreased the odds of being hungry by 22% (OR: 0.78, 95%CI: 0.65-0.94). In uniparental disomy, the odds of being hungry decreased by 66% (OR: 0.34, 90%CI: 0.13-0.9). Postprandial leptin patterns did no differ among genetic subtypes.


CONCLUSIONS
Low baseline BDNF levels and lack of postprandial peak may contribute to persistent hunger after meals. Uniparental disomy is the genetic subtype of PWS least affected by these factors.
Department of Endocrinology and Nutrition, Hospital Universitari Arnau de Vilanova, Lleida, Spain.
Marta
M
Bueno
Specialized Service in Mental Health and Intellectual Disability, Institut Assistència Sanitària (IAS), Parc Hospitalari Martí i Julià, Girona, Spain.
Susanna
S
Esteba-Castillo
Specialized Service in Mental Health and Intellectual Disability, Institut Assistència Sanitària (IAS), Parc Hospitalari Martí i Julià, Girona, Spain.
Ramon
R
Novell
Department of Endocrinology and Nutrition, Sabadell University Hospital, Corporació Sanitària Parc Taulí, Sabadell, Spain, Autonomous University of Barcelona, Bellaterra, Spain.
Olga
O
Giménez-Palop
Mental Health Center, Corporació Sanitària Parc Taulí, Sabadell, Spain.
Ramon
R
Coronas
Pediatric Endocrinology Unit, Sabadell University Hospital, Corporació Sanitària Parc Taulí, Sabadell, Spain.
Elisabeth
E
Gabau
Pediatric Endocrinology Unit, Sabadell University Hospital, Corporació Sanitària Parc Taulí, Sabadell, Spain.
Raquel
R
Corripio
Genetics Laboratory, UDIAT, Corporació Sanitària Parc Taulí, Sabadell, Spain.
Neus
N
Baena
Genetics Laboratory, UDIAT, Corporació Sanitària Parc Taulí, Sabadell, Spain.
Marina
M
Viñas-Jornet
Genetics Laboratory, UDIAT, Corporació Sanitària Parc Taulí, Sabadell, Spain.
Míriam
M
Guitart
Specialized Service in Mental Health and Intellectual Disability, Institut Assistència Sanitària (IAS), Parc Hospitalari Martí i Julià, Girona, Spain.
David
D
Torrents-Rodas
Department of Clinical and Health Psychology, Autonomous University of Barcelona, Bellaterra, Spain.|MRI Research Unit, Department of Radiology, CIBERSAM G21, Hospital del Mar, Barcelona, Spain.|Guttmann Neurorehabilitation Institute, Barcelona, Spain, Autonomous University of Barcelona, Bellaterra, Spain.
Joan
J
Deus
MRI Research Unit, Department of Radiology, CIBERSAM G21, Hospital del Mar, Barcelona, Spain.
Jesús
J
Pujol
Department of Endocrinology and Nutrition, Sabadell University Hospital, Corporació Sanitària Parc Taulí, Sabadell, Spain, Autonomous University of Barcelona, Bellaterra, Spain.
Mercedes
M
Rigla
Department of Endocrinology and Nutrition, Sabadell University Hospital, Corporació Sanitària Parc Taulí, Sabadell, Spain, Autonomous University of Barcelona, Bellaterra, Spain.
Assumpta
http://orcid.org/0000-0001-8472-9189
A
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