In Vitro Activities of Omadacycline (PTK 0796) and Other Antimicrobial Agents against Human Mycoplasmas and Ureaplasmas.
In vitro activities of omadacycline, a new aminomethylcycline, were determined for Mycoplasma and Ureaplasma spp. and compared with those of azithromycin, clindamycin, moxifloxacin, tetracycline, and doxycycline. All omadacycline MICs were <2 μg/ml. MIC90s were 0.063 μg/ml for Mycoplasma hominis, 0.25 μg/ml for Mycoplasma pneumoniae, and 2 μg/ml for Ureaplasma spp. Omadacycline had the lowest MIC90among all drugs tested against M. hominis Omadacycline activity was not affected by macrolide, tetracycline, or fluoroquinolone resistance.
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA kwaites@uabmc.edu.
Ken B
KB
Waites
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Donna M
DM
Crabb
Institute of Antibiotics, Huashan Hospital, Institute of Biomedical Sciences, Fudan University, Shanghai, China.
Yang
Y
Liu
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Lynn B
LB
Duffy
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology; D002681:China; D002981:Clindamycin / Q000494:pharmacology; D004318:Doxycycline / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial; D024841:Fluoroquinolones / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D000077266:Moxifloxacin; D009175:Mycoplasma Infections / Q000382:microbiology; D019535:Mycoplasma hominis / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D009177:Mycoplasma pneumoniae / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D013752:Tetracycline / Q000494:pharmacology; D013754:Tetracyclines / Q000494:pharmacology*; D014481:United States
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D013754:Tetracyclines; C000591640:omadacycline; D002981:Clindamycin; D017963:Azithromycin; D013752:Tetracycline; D004318:Doxycycline; D000077266:Moxifloxacin
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