Ventral striatum and amygdala activity as convergence sites for early adversity and conduct disorder.
Childhood family adversity (CFA) increases the risk for conduct disorder (CD) and has been associated with alterations in regions of affective processing like ventral striatum (VS) and amygdala. However, no study so far has demonstrated neural converging effects of CFA and CD in the same sample. At age 25 years, functional MRI data during two affective tasks, i.e. a reward (N = 171) and a face-matching paradigm (N = 181) and anatomical scans (N = 181) were acquired in right-handed currently healthy participants of an epidemiological study followed since birth. CFA during childhood was determined using a standardized parent interview. Disruptive behaviors and CD diagnoses during childhood and adolescence were obtained by diagnostic interview (2-19 years), temperamental reward dependence was assessed by questionnaire (15 and 19 years).CFA predicted increased CD and amygdala volume. Both exposure to CFA and CD were associated with a decreased VS response during reward anticipation and blunted amygdala activity during face-matching. CD mediated the effect of CFA on brain activity. Temperamental reward dependence was negatively correlated with CFA and CD and positively with VS activity. These findings underline the detrimental effects of CFA on the offspring's affective processing and support the importance of early postnatal intervention programs aiming to reduce childhood adversity factors.
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany.
Nathalie E
NE
Holz
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany.
Regina
R
Boecker-Schlier
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany.|University Outpatient Clinic of the Institute for Psychiatric and Psychosomatic Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany.
Arlette F
AF
Buchmann
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany.
Dorothea
D
Blomeyer
Department of Biostatistics, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany.
Christine
C
Jennen-Steinmetz
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany.
Sarah
S
Baumeister
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany.|Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany.
Michael M
MM
Plichta
Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Anna
A
Cattrell
Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Gunter
G
Schumann
Department of Psychology, University of Potsdam, Potsdam, Germany.
Günter
G
Esser
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany.
Martin
M
Schmidt
Karakter Child and Adolescent Psychiatry University Center, Nijmegen, The Netherlands.|Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Jan
J
Buitelaar
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany.
Andreas
A
Meyer-Lindenberg
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany.
Tobias
T
Banaschewski
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany.|Department of Child and Adolescent Psychiatry, University of Zurich, Neumünsterallee 9, Zurich, 8032, Switzerland.|Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.|Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.
Daniel
D
Brandeis
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany.|Department of Psychology, University of Potsdam, Potsdam, Germany.
Manfred
M
Laucht
D000293:Adolescent; D000679:Amygdala / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D019955:Conduct Disorder / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D006801:Humans; D008016:Life Change Events; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D012201:Reward; D011795:Surveys and Questionnaires; D013694:Temperament / Q000502:physiology; D066328:Ventral Striatum / Q000503:physiopathology*; D035862:Vulnerable Populations; D055815:Young Adult
amygdala; childhood adversity; conduct disorder; fMRI; ventral striatum
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