Contemporary challenges and opportunities in the diagnosis and outbreak detection of multidrug-resistant infectious disease.
The dissemination of multi-drug resistant bacteria (MDRB) has become a major public health concern worldwide because of the increase in infections caused by MDRB, the difficulty in treating them, and expenditures in patient care. Areas covered: We have reviewed challenges and contemporary opportunities for rapidly confronting infections caused by MDRB in the 21st century, including surveillance, detection, identification of resistance mechanisms, and action steps. Expert commentary: In this context, the first critical point for clinical microbiologists is to be able to rapidly detect an abnormal event, an outbreak and/or the spread of a MDRB with surveillance tools so that healthcare policies and therapies adapted to a new stochastic event that will certainly occur again in the future can be implemented.
a URMITE UM 63 CNRS 7278 IRD 198 INSERM U1905, IHU Méditerranée Infection, Faculté de Médecine et de Pharmacie , Aix-Marseille University , Marseille , France.
Teresa
T
Cimmino
a URMITE UM 63 CNRS 7278 IRD 198 INSERM U1905, IHU Méditerranée Infection, Faculté de Médecine et de Pharmacie , Aix-Marseille University , Marseille , France.
Stéphanie
S
Le Page
a URMITE UM 63 CNRS 7278 IRD 198 INSERM U1905, IHU Méditerranée Infection, Faculté de Médecine et de Pharmacie , Aix-Marseille University , Marseille , France.
Didier
D
Raoult
a URMITE UM 63 CNRS 7278 IRD 198 INSERM U1905, IHU Méditerranée Infection, Faculté de Médecine et de Pharmacie , Aix-Marseille University , Marseille , France.
Jean-Marc
JM
Rolain
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001431:Bacteriological Techniques; D064790:Clinical Laboratory Services; D003141:Communicable Diseases / Q000175:diagnosis* / Q000453:epidemiology* / Q000382:microbiology; D019295:Computational Biology / Q000379:methods; D030541:Databases, Genetic; D004196:Disease Outbreaks; D018432:Drug Resistance, Multiple; D024901:Drug Resistance, Multiple, Bacterial; D016680:Genome, Bacterial; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D056186:Metagenomics / Q000379:methods; D019095:Point-of-Care Systems; D011159:Population Surveillance / Q000379:methods; D060888:Real-Time Polymerase Chain Reaction
D000900:Anti-Bacterial Agents
Multi-drug resistant bacteria; challenges; decreased delay of detection; epidemiological surveillance; molecular biology; point-of-care; whole genome sequencing