Effects of Liraglutide and Vitamin E in Fructose-Induced Metabolic Syndrome in Rats.
BACKGROUND
Metabolic syndrome (MetS) is a growing worldwide health problem. However, there is yet no effective therapy for MetS. The present work investigated the effect of liraglutide, a synthetic glucagon-like peptide-1 and vitamin E on fructose-induced MetS in rats.


CONCLUSIONS
Liraglutide (0.3 mg/kg/day) and vitamin E (100 mg/kg/day) were administered either alone or in combination with high fructose-fed male rats for 6 weeks. Fructose-fed rats developed metabolic disorders assessed by visceral fat index, serum glucose, serum insulin, homeostasis model assessment-insulin resistance and serum lipids profile and hepatic disorders assessed by liver index, serum alanine aminotransferase and aspartate aminotransferase and steatohepatitis in histopathology. This study showed that liraglutide, vitamin E and their combination significantly ameliorated the fructose-induced metabolic and hepatic disorders. Key Messages: These results indicate a potential therapeutic benefit of liraglutide and vitamin E combination in prevention of MetS. Their protective effects might rely on their antioxidant effects as well as on the inhibition of tumor necrosis factor-α.
Department of Pharmacology, Faculty of Medicine, Minia University, El-Minia, Egypt.
Ayman
A
Geddawy
Marwa
M
Hussian
Maha Yehia
MY
Kamel
Rehab
R
Kamal
Mohamed A
MA
Ibrahim
D000818:Animals; D004359:Drug Therapy, Combination; D005632:Fructose / Q000633:toxicity*; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D000069450:Liraglutide / Q000008:administration & dosage*; D008297:Male; D024821:Metabolic Syndrome / Q000139:chemically induced* / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome; D014810:Vitamin E / Q000008:administration & dosage*
D007004:Hypoglycemic Agents; D014810:Vitamin E; D005632:Fructose; D000069450:Liraglutide