Fluorouracil implants caused a diaphragmatic tumor to be misdiagnosed as liver metastasis: a case report.
BACKGROUND
Fluorouracil implants are widely used in peritoneal interstitial chemotherapy. Curative effects have been obtained, but implants have also caused some complications.


METHODS
We performed an analysis of a 66-year-old male patient's case history, as well as conventional pathological analysis and Raman spectroscopic detection of the diaphragmatic tumor. We also analyzed the underlying causes of this condition to prevent complications and reduce misdiagnoses in future cases. The patient had a history of peritoneal fluorouracil implantation. Pathological analysis of the diaphragmatic mass revealed foreign particles, and Raman detection showed that the mass contained fluorouracil.


CONCLUSIONS
Fluorouracil implants may persist due to the high concentrations of this drug used in peritoneal chemotherapy. This finding should provide guidance and improve the application of peritoneal implants. In clinical trials, and the diagnosis of liver metastasis should be based on pathological results.
Shandong Cancer Hospital affiliated to Shandong University, Shandong, 250117, People's Republic of China.|Shandong Academy of Medical Sciences, Jinan, Shandong, 250200, People's Republic of China.
Yang-Yang
YY
Shen
Shandong Academy of Agricultural Sciences, Institute of Agricultural Quality Standards and Testing Technology, Jinan, Shandong, 250100, People's Republic of China.
Hong-Wei
HW
Qin
Shandong Cancer Hospital affiliated to Shandong University, Shandong, 250117, People's Republic of China.|Shandong Academy of Medical Sciences, Jinan, Shandong, 250200, People's Republic of China.
Jian-Bo
JB
Zhang
Shandong Cancer Hospital affiliated to Shandong University, Shandong, 250117, People's Republic of China.|Shandong Academy of Medical Sciences, Jinan, Shandong, 250200, People's Republic of China.
Zhen-Dan
ZD
Wang
Shandong Cancer Hospital affiliated to Shandong University, Shandong, 250117, People's Republic of China.|Shandong Academy of Medical Sciences, Jinan, Shandong, 250200, People's Republic of China.
Pang
P
Li
Optoelectronics Technology Co., Ltd. Shandong Ruihua TONGHUI, Jinan, Shandong, 250022, People's Republic of China.
Kai
K
Pang
Shandong Cancer Hospital affiliated to Shandong University, Shandong, 250117, People's Republic of China.|Shandong Academy of Medical Sciences, Jinan, Shandong, 250200, People's Republic of China.
Bo
B
Zhang
Shandong Cancer Hospital affiliated to Shandong University, Shandong, 250117, People's Republic of China.|Shandong Academy of Medical Sciences, Jinan, Shandong, 250200, People's Republic of China.|Shandong Provincial Collaborative Innovation Center for Neurodegenerative, DisordersQingdao University, Qingdao, Shandong, 266071, People's Republic of China.
Sheng
S
Li
Shandong Cancer Hospital affiliated to Shandong University, Shandong, 250117, People's Republic of China. cuikai.ck@163.com.|Shandong Academy of Medical Sciences, Jinan, Shandong, 250200, People's Republic of China. cuikai.ck@163.com.
Kai
K
Cui
Complication; Fluorouracil implants; Liver metastases; Raman spectroscopy; Sinofuan
Gynecol Oncol. 2009 May;113(2):228-32
19254808
Zhonghua Wei Chang Wai Ke Za Zhi. 2014 Jul;17(7):694-7
25070451
J Natl Cancer Inst. 1996 Oct 16;88(20):1456-66
8841020
Zhonghua Wei Chang Wai Ke Za Zhi. 2010 Jan;13(1):57-9
20099164
Clin Endosc. 2011 Sep;44(1):51-4
22741113
Surg Neurol. 2000 May;53(5):458-64
10874145
Oncol Lett. 2014 Aug;8(2):742-744
25013494
Chirurg. 1999 Dec;70(12):1489-91
10637708
Z Gastroenterol. 1983 Feb;21(2):85-8
6342283
Chin Med J (Engl). 2012 Aug;125(15):2764-7
22931989
J Gastric Cancer. 2014 Sep;14(3):204-6
25328766
Zhonghua Wei Chang Wai Ke Za Zhi. 2012 Apr;15(4):377-81
22539386