Pentraxin 3 as a Novel Marker in Cardiovascular Diseases?
Pentraxin 3 (also known as TNFAIP5, TSG-14) belongs to the superfamily of proteins characterized by cyclic multimeric structure. Pentraxin 3 (PTX3) is synthesized locally at the inflammatory sites by endothelial and smooth muscle cells upon exposure to inflammatory signals such as IL-1β, TNF-α or ox-LDL, but not IL-6. Furthermore, PTX3 is highly expressed in vascular cells and myocardial cells in patients with cardiomyopathy. These data suggest that pentraxin 3 may be a useful biomarker for local vascular inflammation and cardiovascular system disorders.
Department of Laboratory Medicine, Collegium Medicum, Nicolaus Copernicus University , Bydgoszcz, Poland.
Bartosz
B
Malinowski
Department of Pharmacology and Therapeutics, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland; Department of Cardiology and Internal Medicine, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
Grzegorz
G
Grzesk
Department of Pharmacology and Therapeutics, Collegium Medicum, Nicolaus Copernicus University , Bydgoszcz, Poland.
Elzbieta
E
Grzesk
Blood. 2000 Dec 15;96(13):4300-6
11110705
Eur J Immunol. 2003 Feb;33(2):465-73
12645945
Arterioscler Thromb Vasc Biol. 2009 Apr;29(4):594-9
19164811
Annu Rev Immunol. 2005;23:337-66
15771574
Circulation. 2000 Aug 8;102(6):636-41
10931803
PLoS One. 2013;8(1):e53133
23372656
Nature. 2002 Dec 19-26;420(6917):868-74
12490960
Vascul Pharmacol. 2006 Nov;45(5):326-30
17023219
Immunol Today. 1994 Feb;15(2):74-80
7512342
Atherosclerosis. 2010 May;210(1):220-5
19945702
Am Heart J. 2008 Jan;155(1):75-81
18082493
Rinsho Byori. 2011 Jul;59(7):694-701
21874796
Eur Cytokine Netw. 2009 Dec;20(4):225-34
20167562
Cochrane Database Syst Rev. 2009 Jan 21;(1):CD007037
19160314
Int J Cardiol. 2008 Oct 30;130(1):19-22
18045709
J Exp Med. 1930 Sep 30;52(4):561-71
19869788
Curr Opin Immunol. 1995 Feb;7(1):54-64
7772283
Circulation. 2004 Aug 3;110(5):588-636
15289388