Impact of Endometrioma Resection on Eutopic Endometrium Metabolite Contents: Noninvasive Evaluation of Endometrium Receptivity.
The aim of this study was to determine whether endometrioma resection alters most commonly defined endometrial metabolites, lactate (Lac), N-acetylaspartate (NAA), creatine 1 (Cr1), creatine 2 (Cr2), and choline (Cho) during the window of implantation. Twenty patients with uni- or bilateral endometrioma and 7 patients having nonendometriotic benign ovarian cyst were included. Midluteal phase magnetic resonance spectroscopy analysis of eutopic endometrium was performed before surgery. Second spectrum of endometrium was obtained 3 to 5 months after laparoscopic endometrioma resection. Pre- and postoperative endometrial peaks of Lac, NAA, Cr, and Cho were measured in units and denominated in parts per million (ppm). Compared to preoperative peak values, significantly decreased NAA, Lac, and Cr1 signals were noted in patients undergoing endometrioma surgery. Nearly 5-fold decline in the NAA signal occurred after endometrioma surgery (1.94 ± 3.24 vs 0.37 ± 0.55). Likewise, 2.5-fold decline in Lac signals was noted after endometrioma resection (2.81 ± 2.64 vs 1.06 ± 1.88). Both uni- and bilateral endometrioma affected endometrium signals the same. The peak intensity of Cho, Cr1, Cr2, NAA, and Lac did not alter significantly after nonendometriotic cyst surgery. Endometrioma surgery straightens endometrial NAA, Lac, and Cr1 peaks, suggesting improvement in endometrial receptivity.
1 Department of Obstetrics and Gynecology, Bahcesehir University School of Medicine, Istanbul, Turkey.
Aynur
A
Ersahin
2 Private Clinic, Obstetrics and Gynecology, Usak, Turkey.
Onder
O
Celik
3 Department of Obstetrics and Gynecology, Medipol University School of Medicine, Istanbul, Turkey.
Mustafa
M
Acet
4 Department of Obstetrics and Gynecology, Kemerburgaz University Medical Faculty, Istanbul, Turkey.
Suphan
S
Ersahin
5 Department of Obstetrics and Gynecology, Medicine Hospital, Istanbul, Turkey.
Tuba
T
Acet
6 Department of Radiology, Altinova Private Hospital, Sakarya, Turkey.
Duygu Kara
DK
Bozkurt
7 Department of Obstetrics and Gynecology, Istanbul Yeniufuk Hospital, Istanbul, Turkey.
Yasemin
Y
Yavuz
8 Department of Medical Pharmacology, Firat University School of Medicine, Elaziğ, Turkey.
Selcuk
S
Ilhan
D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D002794:Choline / Q000737:chemistry / Q000378:metabolism; D003401:Creatine / Q000737:chemistry / Q000378:metabolism; D004715:Endometriosis / Q000378:metabolism* / Q000601:surgery*; D004717:Endometrium / Q000378:metabolism* / Q000601:surgery*; D005260:Female; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D010048:Ovarian Cysts / Q000378:metabolism / Q000601:surgery
D001224:Aspartic Acid; D019344:Lactic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline
endometrioma; eutopic endometrium; laparoscopy; spectroscopy