Atypical anti-glomerular basement membrane disease: lessons learned.
Anti-glomerular basement membrane (GBM) disease usually pursues a self-limited course, at least from the immunological perspective. In addition, circulating antibodies to cryptic, conformational epitopes within the NC1 domain of the alpha 3 chain of Type IV Collagen are commonly found at the zenith of the clinical disease. However, exceptions to these general rules do occur, as exemplified by two remarkable cases reported in this issue of the Clinical Kidney Journal. The possible explanations for and the lessons learned from these uncommon occurrences are discussed in this short commentary.
David Geffen School of Medicine at UCLA , Laguna Niguel, Los Angeles, CA , USA.
Richard J
RJ
Glassock
Ann Intern Med. 1979 Jul;91(1):21-5
111592
Ann Intern Med. 2001 Jun 5;134(11):1033-42
11388816
Am J Kidney Dis. 2002 Jun;39(6):1162-7
12046026
Kidney Int. 2003 Nov;64(5):1685-94
14531801
Kidney Int. 2004 Oct;66(4):1535-40
15458448
Nephrol Dial Transplant. 2006 Feb;21(2):397-401
16234289
Thorax. 2006 Jul;61(7):636-9
16807392
N Engl J Med. 2010 Jul 22;363(4):343-54
20660402
J Immunol. 2010 Sep 15;185(6):3520-8
20709951
Nephrol Dial Transplant. 2012 Jan;27(1):243-52
21562146
Nephrology (Carlton). 2012 Feb;17(2):160-6
21854504
Medicine (Baltimore). 2011 Sep;90(5):303-11
21862934
Clin J Am Soc Nephrol. 2013 Jan;8(1):51-8
23085731
Am J Kidney Dis. 2014 Feb;63(2):289-93
24189476
Kidney Int Suppl (2011). 2012 Jun;2(2):240-242
25018939
J Autoimmun. 2015 May;59:8-18
25841937
Bull Hosp Jt Dis (2013). 2014;72(4):301-4
25986356
Clin Kidney J. 2016 Apr;9(2):211-21
26985371
Kidney Int. 2016 Apr;89(4):897-908
26994577
Medicine (Baltimore). 2016 May;95(19):e3654
27175692
Clin Kidney J. 2016 Oct;9(5):657-60
27679710
Clin Kidney J. 2016 Oct;9(5):661-4
27679711
NDT Plus. 2010 Jun;3(3):253-256
28657027
Br Med J (Clin Res Ed). 1986 Feb 1;292(6516):301-4
3080145
Kidney Int. 1974 Jun;5(6):389-401
4278855
J Exp Med. 1967 Dec 1;126(6):989-1004
4964566
Kidney Int. 1993 Jan;43(1):85-93
7679459
J Am Soc Nephrol. 1995 Oct;6(4):1178-85
8589284
Transplantation. 1996 Jan 27;61(2):228-34
8600629
Clin Nephrol. 1996 Jul;46(1):10-2
8832142
Am J Kidney Dis. 1998 Aug;32(2):323-7
9708621