Is elective single-embryo transfer a viable treatment policy in in vitro maturation cycles?
OBJECTIVE
To compare the clinical outcome of single-embryo transfer (SET) with double-embryo transfer (DET) in in vitro maturation (IVM) cycles performed in patients with polycystic ovary syndrome (PCOS), and to determine which factors predict those outcomes.


METHODS
A retrospective analysis.


METHODS
Private assisted reproduction center.


METHODS
One hundred and fifty-nine women with PCOS.


METHODS
In vitro maturation with elective SET or DET conducted between September 2007 and May 2014.


METHODS
Live-birth rates.


RESULTS
Single-embryo transfer was performed in 83 patients (52.2%), and DET was performed in 76 patients (47.7%). When compared with the patients who had DET, the patients who had SET were statistically significantly younger (32.4 ± 3.5 vs. 24.1 ± 4.2 years) and had a shorter infertility duration (9.2 ± 4.5 vs. 4.4 ± 2.1 years), fewer previous ART cycles (<2 prior attempts, 39.5% vs. 6%; ≥2 prior attempts, 60.5% vs. 0), fewer collected oocytes (15.1 ± 4.6 vs. 12.6 ± 3.8), fewer metaphase II oocytes (9.0 ± 4.1 vs. 5.7 ± 2.9), fewer fertilized oocytes (8.2 ± 3.7 vs. 3.6 ± 2.3), and a higher implantation rate (27% vs. 47%). The SET and DET groups had similar embryo quality and similar clinical pregnancy (44.6% vs. 44.7%) and live-birth rates (34.9% vs. 34.2%). Twin pregnancy rates were statistically significantly higher in the DET compared with the SET groups (9.2% vs. 2.4%).


CONCLUSIONS
In vitro maturation is a successful assisted reproduction technique that can be an alternative to conventional in vitro fertilization in women presenting with PCOS-related infertility. Our observations suggest that SET is a feasible option to prevent multiple pregnancies while maintaining the live-birth rate.
In Vitro Fertilization Center, Konak Hastanesi, İzmit, Kocaeli, Turkey.
Safak
S
Hatırnaz
In Vitro Fertilization Center, Konak Hastanesi, İzmit, Kocaeli, Turkey.
Ebru
E
Hatırnaz
Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada; OriginElle Reporductive and Womens' Health Center, Montreal, Quebec, Canada.
Michael H
MH
Dahan
Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada; OriginElle Reporductive and Womens' Health Center, Montreal, Quebec, Canada.
Seang Lin
SL
Tan
Department of Obstetrics and Gynecology, Sutcu Imam University, Kahramanmaras, Turkey.
Alev
A
Ozer
Department of Obstetrics and Gynecology, Afyon Kocatepe University Hospital, Afyon, Turkey.
Mine
M
Kanat-Pektas
Department of Obstetrics and Gynecology, School of Medicine, Koc University, Istanbul, Turkey. Electronic address: barisata@ku.edu.tr.
Baris
B
Ata
D000328:Adult; D005240:Feasibility Studies; D005260:Female; D005298:Fertility; D005300:Fertility Agents, Female / Q000627:therapeutic use; D006801:Humans; D059471:In Vitro Oocyte Maturation Techniques; D007247:Infertility, Female / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D050498:Live Birth; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D056826:Single Embryo Transfer; D020554:Sperm Injections, Intracytoplasmic; D016896:Treatment Outcome; D055815:Young Adult
D005300:Fertility Agents, Female
Assisted reproduction; in vitro maturation; polycystic ovary syndrome; predictors of pregnancy