Shining into the White: The Spectrum of Epithelial Tumors from Actinic Keratosis to Squamous Cell Carcinoma.
Actinic keratosis, Bowen disease, and invasive squamous cell carcinoma represent different steps within the disease continuum of squamous neoplasia. Although these stages of squamous neoplasia share common findings, reflectance confocal microscopy may be applied for their differentiation and distinction from other benign or malignant lesions. Hyperkeratosis represents the most important limitation in the evaluation of squamous neoplasia as it may impair the analysis of deeper epidermal and dermal structures significantly.
Private Dermatology Office/CMB Collegium Medicum Berlin, Luisenstrasse 54/55, Berlin 10117, Germany. Electronic address: martinaulrich@gmx.net.
Martin
M
Ulrich
Non-Melanoma Skin Cancer Unit, Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria.
Iris
I
Zalaudek
Department of Dermatology, General Hospital Augsburg, Germany.
J
J
Welzel
D001913:Bowen's Disease / Q000000981:diagnostic imaging*; D002278:Carcinoma in Situ / Q000000981:diagnostic imaging*; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging; D046169:Dermoscopy; D006801:Humans; D000069416:Intravital Microscopy; D055623:Keratosis, Actinic / Q000000981:diagnostic imaging*; D018613:Microscopy, Confocal; D012878:Skin Neoplasms / Q000000981:diagnostic imaging*
Actinic keratosis; Bowen disease; Dermoscopy; Reflectance confocal microscopy; Skin imaging; Squamous cell carcinoma