Cognitive Function and Heat Shock Protein 70 in Children With Temporal Lobe Epilepsy.
We conducted the present study to examine cognitive function and serum heat shock protein 70 levels among children with temporal lobe epilepsy. The Stanford-Binet Intelligence Test was carried out to examine cognitive function in 30 children with temporal lobe epilepsy and 30 controls. Serum heat shock protein 70 levels were determined with an enzyme-linked immunosorbent assay. The epilepsy group had significantly lower cognitive function testing scores and significantly higher serum heat shock protein 70 levels than the control group; there were significant negative correlations between serum heat shock protein 70 levels and short-term memory and composite scores. Children with uncontrolled seizures had significantly lower verbal reasoning scores and significantly higher serum heat shock protein 70 levels than children with controlled seizures. Children with temporal lobe epilepsy have cognitive dysfunction and elevated levels of serum heat shock protein 70, which may be considered a stress biomarker.
1 Department of Pediatrics, Faculty of Medicine, Cairo University, Giza, Egypt.
Azza M
AM
Oraby
2 Department of Research on Children with Special Needs, National Research Centre, Centre of Excellence of Medical Research, Cairo, Egypt.
Ehab R Abdol
ER
Raouf
2 Department of Research on Children with Special Needs, National Research Centre, Centre of Excellence of Medical Research, Cairo, Egypt.
Mostafa M
MM
El-Saied
1 Department of Pediatrics, Faculty of Medicine, Cairo University, Giza, Egypt.
Maha K
MK
Abou-Khadra
2 Department of Research on Children with Special Needs, National Research Centre, Centre of Excellence of Medical Research, Cairo, Egypt.
Suzette I
SI
Helal
2 Department of Research on Children with Special Needs, National Research Centre, Centre of Excellence of Medical Research, Cairo, Egypt.
Adel F
AF
Hashish
D000367:Age Factors; D017668:Age of Onset; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003071:Cognition / Q000502:physiology; D060825:Cognitive Dysfunction / Q000097:blood / Q000209:etiology; D004797:Enzyme-Linked Immunosorbent Assay; D004833:Epilepsy, Temporal Lobe / Q000097:blood* / Q000523:psychology*; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000097:blood*; D006801:Humans; D007361:Intelligence Tests; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology
D015415:Biomarkers; D018840:HSP70 Heat-Shock Proteins
children; cognitive function; heat shock protein 70; stress biomarker; temporal lobe epilepsy