Cell fate regulation by chromatin ADP-ribosylation.
ADP-ribosylation is an evolutionarily conserved complex posttranslational modification that alters protein function and/or interaction. Intracellularly, it is mainly catalyzed by diphtheria toxin-like ADP-ribosyltransferases (ARTDs), which attach one or several ADP-ribose residues onto target proteins. Several specific mono- and poly-ADP-ribosylation binding modules exist; hydrolases reverse the modification. The best-characterized ARTD family member, ARTD1, regulates various DNA-associated processes. Here, we focus on the role of ARTD1-mediated chromatin ADP-ribosylation in development, differentiation, and pluripotency, and the recent development of new methodologies that will enable more insight into these processes.
Department of Molecular Mechanisms of Disease, University of Zurich, Winterthurerstr. 190, 8057 Zurich, Switzerland.
Jeannette
J
Abplanalp
Department of Molecular Mechanisms of Disease, University of Zurich, Winterthurerstr. 190, 8057 Zurich, Switzerland. Electronic address: michael.hottiger@dmmd.uzh.ch.
Michael O
MO
Hottiger
D000074744:ADP-Ribosylation; D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D019070:Cell Lineage / Q000235:genetics; D002843:Chromatin / Q000378:metabolism*; D044127:Epigenesis, Genetic; D006801:Humans; D011499:Protein Processing, Post-Translational / Q000235:genetics
D002843:Chromatin
ADP-ribosylation; ARTD; Chromatin; Differentiation; Histone; PARP; Pluripotency