Tip60: Main Functions and Its Inhibitors.
BACKGROUND
Tip60, the founding member of MYST histone acetyltransferase family, was originally identified as a cellular acetyltransferase protein that interacts with HIV-1 Tat. Tip60 plays roles in many processes such as cellular signaling transmission, DNA damage repair, cell cycle and checkpoint control and apoptosis by acetylating its histone or non-histone substrates.


RESULTS
Dysfunction of Tip60 could promote or suppress diseases including different kinds of cancers.


CONCLUSIONS
Here, main functions and its known inhibitors were summarized.
Department of Pharmacy, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China.
Xiaoli
X
Zhang
Department of Pharmacy, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China.
Jiyong
J
Wu
Department of Medicinal Chemistry, School of Pharmacy, Qingdao University, Qingdao, Shandong Province, China.
Yepeng
Y
Luan
D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D051548:Histone Acetyltransferases / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D006801:Humans; D000074443:Lysine Acetyltransferase 5; D008958:Models, Molecular; D015394:Molecular Structure
D004791:Enzyme Inhibitors; D051548:Histone Acetyltransferases; C098489:KAT5 protein, human; D000074443:Lysine Acetyltransferase 5
Cancer; HATs; HDACs; Tip60; histone acetyltransferase; inhibitor; ε-amino