Synthesis of Trifluoromethyl-allenes by Gold-Catalyzed Rearrangement of Propargyl Benzyl Ethers.
A new method for the synthesis of trifluoromethyl-allenes from easily accessible α-trifluoromethyl-propargyl benzyl ether derivatives following a gold-catalyzed intramolecular hydride transfer has been developed. Various di- and trisubstituted trifluoromethyl-allenes were obtained in good to excellent yields.
Laboratoire de Synthèse Organique, UMR 7652 CNRS/Ecole Polytechnique, Ecole Polytechnique , Route de Saclay, 91128 Palaiseau, France.|Institute of Condensed Matter and Nanosciences (IMCN), Division of Molecules, Solids and Reactivity (MOST), Université Catholique de Louvain , Place Louis Pasteur 1, bte L4.01.02, 1348 Louvain-la-Neuve, Belgium.
Arnaud
A
Boreux
Laboratoire de Synthèse Organique, UMR 7652 CNRS/Ecole Polytechnique, Ecole Polytechnique , Route de Saclay, 91128 Palaiseau, France.
Geoffroy H
GH
Lonca
Institute of Condensed Matter and Nanosciences (IMCN), Division of Molecules, Solids and Reactivity (MOST), Université Catholique de Louvain , Place Louis Pasteur 1, bte L4.01.02, 1348 Louvain-la-Neuve, Belgium.
Olivier
O
Riant
Laboratoire de Synthèse Organique, UMR 7652 CNRS/Ecole Polytechnique, Ecole Polytechnique , Route de Saclay, 91128 Palaiseau, France.
Fabien
F
Gagosz