Serum 25(OH) Vitamin D Levels in Polish Women during Pregnancies Complicated by Hypertensive Disorders and Gestational Diabetes.
BACKGROUND
An association between the level of vitamin D and the risk of pregnancy-related complications remains unclear. The aim of this study was to examine concentrations of 25(OH) vitamin D in Polish women with normal pregnancies and pregnancies complicated by gestational hypertension, preeclampsia or gestational diabetes mellitus (GDM). Moreover, we analyzed an association between maternal serum 25(OH)D and the risk of gestational hypertension, preeclampsia and GDM.


METHODS
The study included 207 pregnant women, among them 171 with pregnancy-related complications: gestational hypertension (n= 45), preeclampsia (n= 23) or GDM (n= 103). The control group consisted of 36 women with normal pregnancies. Concentrations of serum 25(OH)D were measured at admission to the hospital prior to delivery Results: Patients with hypertension did not differ significantly from the controls in terms of their serum 25(OH)D concentrations (18.20 vs. 22.10 ng/mL,p= 0.15). Highly significant differences were found in 25(OH)D concentrations of women with preeclampsia and the controls (14.75 vs. 22.10 ng/mL,p= 0.0021). GDM was not associated with significant differences in 25(OH)D concentration. A low level of 25(OH)D turned out to be associated with an increased risk of preeclampsia during pregnancy on both univariate and multivariate regression analysis, and was a significant predictor of this condition on ROC (receiver operating characteristic) analysis (AUC = 0.70,p< 0.01).


CONCLUSIONS
25(OH)D deficiency is common among pregnant Polish women. Low concentrations of 25(OH)D may play a role in the etiopathogenesis of preeclampsia. Routine assessment of the 25(OH)D level during pregnancy may be crucial for the identification of women at increased risk of preeclampsia.
Department of Obstetrics and Gynecology, L. Rydygier Collegium in Bydgoszcz, Nicolaus Copernicus University, ul. Ujejskiego 75, Bydgoszcz 85-168, Poland. domarackipiotr@gmail.com.
Piotr
P
Domaracki
Department of Obstetrics and Gynecology, L. Rydygier Collegium in Bydgoszcz, Nicolaus Copernicus University, ul. Ujejskiego 75, Bydgoszcz 85-168, Poland. pawelsadlecki@wp.pl.
Pawel
P
Sadlecki
Department of Laboratory Medicine, L. Rydygier Collegium in Bydgoszcz, Nicolaus Copernicus University, M. Curie Skłodowskiej 9, Bydgoszcz 85-094, Poland. grazynaodes@interia.pl.
Grazyna
G
Odrowaz-Sypniewska
Department of Obstetrics and Gynecology, L. Rydygier Collegium in Bydgoszcz, Nicolaus Copernicus University, ul. Ujejskiego 75, Bydgoszcz 85-168, Poland. evi1710@op.pl.
Ewa
E
Dzikowska
Department of Obstetrics and Gynecology, L. Rydygier Collegium in Bydgoszcz, Nicolaus Copernicus University, ul. Ujejskiego 75, Bydgoszcz 85-168, Poland. walentowiczp@gmail.com.
Pawel
P
Walentowicz
Department of Laboratory Medicine, L. Rydygier Collegium in Bydgoszcz, Nicolaus Copernicus University, M. Curie Skłodowskiej 9, Bydgoszcz 85-094, Poland. asiapollak@wp.pl.
Joanna
J
Siodmiak
Department of Obstetrics and Gynecology, L. Rydygier Collegium in Bydgoszcz, Nicolaus Copernicus University, ul. Ujejskiego 75, Bydgoszcz 85-168, Poland. grabiecm@cm.umk.pl.
Marek
M
Grabiec
Department of Obstetrics and Gynecology, L. Rydygier Collegium in Bydgoszcz, Nicolaus Copernicus University, ul. Ujejskiego 75, Bydgoszcz 85-168, Poland. walentowiczm@cm.umk.pl.
Malgorzata
M
Walentowicz-Sadlecka
25(OH)D; gestational diabetes; gestational hypertension; preeclampsia
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