Constitutional t(8;22)(q24;q11.2) that mimics the variant Burkitt-type translocation in Philadelphia chromosome-positive chronic myeloid leukemia.
Constitutional translocations that coincide with t(9;22)(q34;q11.2) may lead to unnecessary treatments in chronic myeloid leukemia (CML) patients, as, under the standard criteria, a diagnosis of CML with additional chromosomal abnormalities indicates an accelerated phase (AP). In the present report, a 47-year-old male had pain in the right foot due to gout. Peripheral blood examination showed leukocytosis with left shift. Bone marrow aspiration revealed myeloid hyperplasia with megakaryocytosis. RT-PCR revealed the major BCR-ABL fusion transcript, and CML in the chronic phase was diagnosed, followed by nilotinib treatment. Although WBC counts decreased immediately, G-banding analysis showed 46,XY,t(8;22)(q24;q11.2),t(9;22)(q34;q11.2) [20]. The t(8;22)(q24;q11.2) translocation is known to be recurrent in Burkitt's lymphoma. The diagnosis was changed to CML in AP, leading to B-lymphoid crisis. Unexpectedly, the karyotype was 46,XY,t(8;22)(q24;q11.2) [20] in hematological complete remission, even after 3 months. Fluorescence in situ hybridization on metaphase spreads revealed the MYC signal on the der(22)t(8;22), indicating that the 8q24 breakpoint was centromeric to MYC at 8q24.21. G-banding analysis of phytohemagglutinin-stimulated peripheral blood T-lymphocytes also indicated 46,XY,t(8;22)(q24.1;q11.2). We conclude that the t(8;22) is constitutional in this patient. As the tumor suppressor gene TRC8/RNF139 is disrupted by constitutional t(8;22)(q24.13;q11.21) in dysgerminoma, it may be associated with the onset of CML.
Department of Medical Oncology/Hematology, Kobe University Hospital, Chuoh-ku Kusunokicho 7-5-2, Kobe City, Hyogo, 650-0017, Japan. skawamo@med.kobe-u.ac.jp.
Shinichiro
S
Kawamoto
Department of Medical Oncology/Hematology, Kobe University Hospital, Chuoh-ku Kusunokicho 7-5-2, Kobe City, Hyogo, 650-0017, Japan.
Katsuya
K
Yamamoto
Department of Medical Oncology/Hematology, Kobe University Hospital, Chuoh-ku Kusunokicho 7-5-2, Kobe City, Hyogo, 650-0017, Japan.
Masanori
M
Toyoda
Department of Medical Oncology/Hematology, Kobe University Hospital, Chuoh-ku Kusunokicho 7-5-2, Kobe City, Hyogo, 650-0017, Japan.
Kimikazu
K
Yakushijin
Department of Medical Oncology/Hematology, Kobe University Hospital, Chuoh-ku Kusunokicho 7-5-2, Kobe City, Hyogo, 650-0017, Japan.
Hiroshi
H
Matsuoka
Department of Medical Oncology/Hematology, Kobe University Hospital, Chuoh-ku Kusunokicho 7-5-2, Kobe City, Hyogo, 650-0017, Japan.
Hironobu
H
Minami
D002051:Burkitt Lymphoma / Q000175:diagnosis / Q000235:genetics; D002871:Chromosome Banding; D002892:Chromosomes, Human, Pair 22; D002898:Chromosomes, Human, Pair 8; D003937:Diagnosis, Differential; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000235:genetics; D015465:Leukemia, Myeloid, Accelerated Phase / Q000175:diagnosis* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic / Q000235:genetics*
CML; Constitutional; Non-Robertsonian translocation; t(8;22)
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