Adiponectin protects the rats liver against chronic intermittent hypoxia induced injury through AMP-activated protein kinase pathway.
This study was performed to assess the effect of chronic intermittent hypoxia (CIH) on the liver, the associated mechanisms and the potential therapeutic roles of adiponectin (Ad). Sixty rats were randomly assigned to four groups: the normal control (NC), NC and Ad supplement (NC + Ad), CIH, and CIH and Ad supplement (CIH + Ad) groups. The rats in the CIH and CIH + Ad groups were exposed to a hypoxic environment for 4 months. Rats in the NC + Ad and CIH + Ad groups were also treated with an intravenous injection of Ad (10 ug), twice a week. The plasma levels of hepatic enzymes, serum triglyceride, liver triglyceride, fasting blood glucose and hepatic cell apoptosis in hepatic tissue, were higher in the CIH group than in the NC and NC + Ad groups. However, the Ad supplementation in the CIH + Ad group rescued the hepatic tissue insult by activating the AMP-activated protein kinase (AMPK) pathway. In conclusion, Ad could protect against CIH-induced hepatic injury partly through the AMPK pathway.
Department of Respirology, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China.
Wenxiao
W
Ding
Department of Respirology, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China.
Qiang
Q
Zhang
Department of Respirology, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China.
Yanbin
Y
Dong
Department of Respirology, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China.
Ning
N
Ding
Department of Respirology, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China.
Hanpeng
H
Huang
Department of Respirology, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China.
Xianji
X
Zhu
Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, U.S.A.
Sean
S
Hutchinson
Department of Physiology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, China.
Xingya
X
Gao
Department of Respirology, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China.
Xilong
X
Zhang
Nat Med. 2002 Nov;8(11):1288-95
12368907
Nat Cell Biol. 2011 Sep 02;13(9):1016-23
21892142
Hepatology. 2007 Apr;45(4):1007-13
17393512
Theriogenology. 2013 Aug;80(3):248-55
23755802
Cancer Res. 1996 Jul 15;56(14):3250-6
8764117
Diabet Med. 2010 Apr;27(4):423-30
20536514
Ann Hepatol. 2015 Jan-Feb;14(1):108-17
25536648
Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E663-70
20028965
Endocr Rev. 2005 May;26(3):439-51
15897298
Sleep. 2008 Jan;31(1):121-6
18220085
Nat Clin Pract Cardiovasc Med. 2009 Jan;6(1):27-35
19029992
Apoptosis. 2006 Aug;11(8):1339-47
16703261
Nat Rev Mol Cell Biol. 2012 Mar 22;13(4):251-62
22436748
Am J Med. 2003 Apr 1;114(5):370-6
12714126
Eur Heart J. 2004 May;25(9):735-41
15120883
Chin Med J (Engl). 2013;126(17 ):3270-5
24033948
Genes Dev. 2004 Dec 15;18(24):3066-77
15601821
Ann Thorac Med. 2012 Jan;7(1):26-30
22347347
Mol Cell Biol. 2001 Feb;21(4):1249-59
11158311
Cell. 2004 Jan 23;116(2):205-19
14744432
Free Radic Biol Med. 2010 Mar 15;48(6):749-62
20045723
Nat Cell Biol. 2011 Mar;13(3):184-90
21364565
Gastroenterology. 2008 Feb;134(2):568-76
18082745
Cell. 2004 Jun 25;117(7):855-8
15210107
Cardiovasc Diabetol. 2013 Nov 02;12 :158
24180212
Curr Opin Cell Biol. 2011 Apr;23(2):143-9
21146390
J Mol Cell Cardiol. 2010 Aug;49(2):210-20
20206634
Antioxid Redox Signal. 2006 Nov-Dec;8(11-12):2179-86
17034361
PLoS One. 2014 Oct 20;9(10 ):e109284
25329318
PLoS One. 2014 Apr 09;9(4):e94545
24718591
PLoS One. 2013 Dec 05;8(12):e81870
24339975
Nat Rev Mol Cell Biol. 2007 Jul;8(7):519-29
17565364
Am J Physiol Heart Circ Physiol. 2003 Jun;284(6):H2351-9
12742833
J Clin Invest. 2005 Oct;115(10 ):2656-64
16200199
Cardiovasc Diabetol. 2012 Dec 18;11:151
23249664
Diabetes. 2009 Oct;58(10 ):2246-57
19592618
Mol Cell Biol. 2000 Sep;20(18):6731-40
10958671
Cell Death Dis. 2012 Mar 08;3:e279
22402603
Hepatology. 2005 Jun;41(6):1290-6
15915459
Am J Physiol. 1999 Jul;277(1 Pt 1):E1-10
10409121
Cardiovasc Res. 2000 Feb;45(3):630-41
10728384
Am J Respir Crit Care Med. 2014 Jan 1;189(1):66-76
24256086
Biochem J. 2009 Jun 26;421(2):163-9
19442239
Biochim Biophys Acta. 2012 Feb;1823(2):327-34
22182703
Obes Rev. 2013 May;14(5):417-31
23387384
Diabetes. 2012 Jan;61(1):217-28
22124463
Cell Physiol Biochem. 2013;31(2-3):452-61
23548631
Cancer Cell Int. 2010 Jun 30;10:22
20591184
Science. 2000 Aug 18;289(5482):1150-1
10970229
Cancer Res. 1997 Feb 15;57(4):686-95
9044846
J Neurotrauma. 2000 Oct;17(10):801-10
11063049
J Cardiol. 2012 Dec;60(6):475-83
22890070
J Am Coll Cardiol. 2011 Jan 11;57(2):119-27
21211682
Thorax. 2004 Sep;59(9):777-82
15333855
Eur Heart J. 2012 Mar;33(6):783-90
21478490
J Am Soc Nephrol. 2010 Mar;21(3):406-12
20150538
Exp Diabetes Res. 2012;2012:509437
22474424
Dig Dis Sci. 2005 Dec;50(12):2338-43
16416185
J Biol Chem. 2002 Sep 13;277(37):34287-94
12097332
J Biol Chem. 1957 May;226(1):497-509
13428781
Am J Physiol Cell Physiol. 2013 Feb 15;304(4):C342-53
23242184
Hepatology. 2013 Apr;57(4):1564-74
23174804
Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H1639-45
20348222
Respir Physiol Neurobiol. 2010 Dec 31;174(3):307-16
20833273