Thrombolysis and thrombectomy in patients treated with dabigatran with acute ischemic stroke: Expert opinion.
Systemic thrombolysis with rt-PA is contraindicated in patients with acute ischemic stroke anticoagulated with dabigatran. This expert opinion provides guidance on the use of the specific reversal agent idarucizumab followed by rt-PA and/or thrombectomy in patients with ischemic stroke pre-treated with dabigatran. The use of idarucizumab followed by rt-PA is covered by the label of both drugs.
1 Department of Neurology, University Duisburg-Essen, Essen, Germany.
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HC
Diener
2 Northwestern Stroke Program, Chicago, IL, USA.|3 Feinberg School of Medicine of Northwestern University, Chicago, IL, USA.
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R
Bernstein
4 Division of Neurology, University of Alberta, Edmonton, AB, Canada.
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K
Butcher
5 Department of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia.
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B
Campbell
6 The Department of Neurology, Atkinson Morley's Wing, St George's University Hospitals NHS Foundation Trust, London, UK.
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G
Cloud
7 Department of Neurosciences, Hospital Germans Trias I Pujol, Universidad Autònoma de Barcelona, Barcelona, Spain.
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A
Davalos
8 Department of Translational Neuroscience, University of Melbourne, Victoria, Australia.
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S
Davis
9 Department of Neurosciences and Mental Health, Hospital Santa Maria - CHLN, University of Lisbon, Lisbon, Portugal.
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JM
Ferro
10 Department of Neurology, Kreisklinikum Siegen, Germany.
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Grond
11 Comprehensive Stroke Center, University of Zurich, Zurich, Switzerland.|12 Cityhospital Mediclinic, Dubai Health Care City, Dubai, UAE.
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Krieger
13 Department of Medicine, University of Thessaly, Larissa, Greece.
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Ntaios
14 Department of Neurology, Medical College, Jagiellonian University, Krakow, Poland.
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A
Slowik
15 Normandie University, UNICAEN, Inserm U919, Department of Neurology, Caen, France.
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Touzé
D000991:Antithrombins / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000517:prevention & control / Q000628:therapy*; D000069604:Dabigatran / Q000627:therapeutic use*; D006801:Humans; D020521:Stroke / Q000517:prevention & control / Q000628:therapy*; D017131:Thrombectomy; D015912:Thrombolytic Therapy
D000991:Antithrombins; D000069604:Dabigatran
Ischemic stroke; dabigatran; idarucizumab; rt-PA; thrombectomy; thrombolysis