Feed exposure to FB1 can aggravate pneumonic damages in pigs provoked by P. multocida.
The possible interaction between Pasteurella multocida and the mycotoxin fumonisin B1 (FB1), recognised as one of the most often food/feed contaminant, was studied with the aim to evaluate whether and how FB1 can influence and/or complicate the development and severity of various pathological damages provoked by Pasteurella multocida in some internal organs of pigs. Heavier lung pathology was seen in pigs experimentally infected with Pasteurella multocida, when the same were exposed to 20ppm dietary levels of fumonisin B1 (FB1) as was assessed by gross pathology, pathomorphological examinations, clinical biochemistry and some immunological investigations. The most typical damages in FB1 treated pigs were the strong oedema in the lung and the slight oedema in the other internal organs and mild degenerative changes in the kidneys, whereas the typical pathomorphological findings in pigs infected with Pasteurella multocida was broncho-interstitial pneumonia. FB1 was found to aggravate pneumonic changes provoked by P. multocida in the cranial lobes of the lung and to complicate pneumonic damages with interstitial oedema in the lung. No macroscopic damages were observed in the pigs infected only with Pasteurella multocida. It can be concluded that the feed intake of FB1 in pigs may complicate or exacerbate the course of P. multocida serotype A infection.
Faculty of Animal Science, Kaposvár University, Guba Sándor u. 40, H-7400 Kaposvár, Hungary; MTA-KE Mycotoxins in the food chain Research Group, Guba Sándor u. 40, H-7400 Kaposvár, Hungary.
Melinda
M
Kovács
Faculty of Animal Science, Kaposvár University, Guba Sándor u. 40, H-7400 Kaposvár, Hungary.
Roland
R
Pósa
Department of Microbiology and Infectious Diseases, Faculty of Veterinary Science, Szent István University, Hungária krt 23-25, H-1143 Budapest, Hungary.
Tamás
T
Tuboly
Faculty of Animal Science, Kaposvár University, Guba Sándor u. 40, H-7400 Kaposvár, Hungary.
Tamás
T
Donkó
Faculty of Animal Science, Kaposvár University, Guba Sándor u. 40, H-7400 Kaposvár, Hungary.
Imre
I
Repa
Faculty of Animal Science, Kaposvár University, Guba Sándor u. 40, H-7400 Kaposvár, Hungary.
János
J
Tossenberger
MTA-KE Mycotoxins in the food chain Research Group, Guba Sándor u. 40, H-7400 Kaposvár, Hungary.
Judit
J
Szabó-Fodor
Dept of General and clinical pathology, Faculty of Veterinary Medicine, Trakia University, Stara Zagora 6000, Bulgaria. Electronic address: stoev@uni-sz.bg.
Stoycho
S
Stoev
Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Hungária krt. 21, H-1143, Budapest, Hungary.
Tibor
T
Magyar
D000821:Animal Feed / Q000032:analysis; D000818:Animals; D004032:Diet / Q000662:veterinary; D005506:Food Contamination / Q000032:analysis; D037341:Fumonisins / Q000633:toxicity*; D009183:Mycotoxins / Q000633:toxicity*; D010326:Pasteurella Infections / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D016979:Pasteurella multocida / Q000502:physiology*; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology / Q000473:pathology*
D037341:Fumonisins; D009183:Mycotoxins; C056933:fumonisin B1
Clinical chemistry; Fumonisin B(1); Immune response; Pasteurella multocida; Pathomorphology; Pigs