Comparison of clinicopathological features and prognosis of gastric cancer located in the lesser and greater curve.
OBJECTIVE
Little is known about the features of gastric cancer located in the lesser and greater curve. This study aims to investigate the clinicopathological features and prognosis of gastric cancer located in the lesser and greater curve.


METHODS
From September 2008 to March 2015, 780 gastric cancer patients were enrolled in the present study. The associations between locations and features of patients were analyzed.


RESULTS
There were 571 male (73.2 %) and 209 female (26.8 %) patients. The median age was 56 years (ranged 21-86). There were 684 tumors located in the lesser curve (87.7 %) and 96 located in the greater curve (12.3 %). The incidence of melena was significantly lower in patients with tumors located in the lesser curve than that in the greater curve (8.5 vs 15.6 %, P = 0.024). The median size of tumors in the lesser curve was significantly larger than that in the greater curve (5.0 (0.3-15) vs 4.0 cm (0.5-15), P = 0.001). The remaining clinicopathological features were comparable between the two groups (all P > 0.05). Tumor location was not a risk factor for the prognosis of gastric cancer by univariate and multivariate analysis (both P > 0.05). The postoperative complications (all P > 0.05) and prognoses (P = 0.279) were comparable between tumors located in the lesser and greater curve.


CONCLUSIONS
The ratio of gastric cancer located in the lesser to greater curve was 7.1:1. Compared with tumors located in the greater curve, the incidence of melena was significantly lower and the tumor size was significantly larger in tumors located in the lesser curve. The prognoses were comparable between tumors located in the lesser and greater curve.
Division of Digestive Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West Changle Road, Xi'an, 710032, Shaanxi, China.
F
F
Feng
Department of Dermatology, Xijing Hospital, Fourth Military Medical University, 127 West Changle Road, Xi'an, 710032, Shaanxi, China.
Y
Y
Tian
Division of Digestive Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West Changle Road, Xi'an, 710032, Shaanxi, China.
M
M
Guo
Division of Digestive Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West Changle Road, Xi'an, 710032, Shaanxi, China.
S
S
Liu
Division of Digestive Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West Changle Road, Xi'an, 710032, Shaanxi, China.
G
G
Xu
Division of Digestive Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West Changle Road, Xi'an, 710032, Shaanxi, China.
Z
Z
Liu
Division of Digestive Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West Changle Road, Xi'an, 710032, Shaanxi, China.
G
G
Zheng
Division of Digestive Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West Changle Road, Xi'an, 710032, Shaanxi, China.
X
X
Lian
Division of Digestive Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West Changle Road, Xi'an, 710032, Shaanxi, China.
D
D
Fan
Division of Digestive Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West Changle Road, Xi'an, 710032, Shaanxi, China. zhanghwfmmu@126.com.
H
H
Zhang
D002288:Adenocarcinoma, Mucinous / Q000556:secondary* / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018279:Carcinoma, Signet Ring Cell / Q000556:secondary* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011183:Postoperative Complications; D011379:Prognosis; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery; D015996:Survival Rate; D055815:Young Adult
Features; Gastric cancer; Greater curve; Lesser curve; Prognosis
J Clin Pathol. 1995 Apr;48(4):325-9
7615851
Clin Transl Gastroenterol. 2015 Sep 10;6:e110
26355434
Anat Rec. 1949 Jan;103(1):1-18
18108865
Chir Ital. 1981 Dec;33(6):1251-4
7343124
Sci Transl Med. 2014 Aug 20;6(250):250ra115
25143365
Gastroenterology. 2000 Jan;118(1):36-47
10611152
Lab Invest. 2009 Dec;89(12):1410-22
19841619
CA Cancer J Clin. 2016 Mar-Apr;66(2):115-32
26808342
Eur J Surg Oncol. 2016 Jan;42(1):18-27
26632080
Digestion. 1980;20(2):79-84
7364161
CA Cancer J Clin. 2015 Mar;65(2):87-108
25651787
Science. 2004 Nov 26;306(5701):1568-71
15567866
Am J Gastroenterol. 2000 Jun;95(6):1431-8
10894575
Hum Pathol. 1993 Jun;24(6):577-83
8505036
J Gastroenterol. 2016 Apr;51(4):313-26
26428661
Tumour Biol. 2012 Dec;33(6):2091-8
22869239
Medicine (Baltimore). 2015 Aug;94(34):e1386
26313779