Role of Oxidative Stress in Hepatitis C Virus Induced Hepatocellular Carcinoma.
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. Hepatitis C virus (HCV) infection is the predominant cause of chronic liver diseases and HCC, particularly in Western countries. Multiple molecular mechanisms are involved in the development and progression of HCV-related HCC, of which oxidative stress plays a pivotal role. HCV infection induces overproduction of reactive oxygen species (ROS) and impairs the function of endogenous antioxidants. Excessive amount of ROS directly damages DNA, lipids and proteins. Meanwhile, ROS indirectly activates a series of signaling cascades, and modulates the activity of many transcription factors, resulting in altered expression of genes that control cell survival, proliferation, angiogenesis, invasion and metastasis. In this review, we aim to summarize the possible molecular mechanisms underlying the link between the oxidative stress and hepatocarcinogenesis in HCV-infected individuals, in order to facilitate discovery of possible approaches or interventional targets for HCV-related HCC.
Department of Traditional and Western Medical Hepatology, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
Na
N
Fu
The Second Department of General Surgery, The Second People's Hospital of Lanzhou City, Lanzhou 730046, China.
Hui
H
Yao
Department of Traditional and Western Medical Hepatology, The Third Hospital of Hebei Medical University, 139 Ziqiang Road, Shijiazhuang 050051, China.
Yuemin
Y
Nan
Storr Liver Centre, Westmead Millennium Institute for Medical Research, the University of Sydney at Westmead Hospital, Westmead, NSW 2145, Australia.
Liang
L
Qiao
D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D004260:DNA Repair; D058750:Epithelial-Mesenchymal Transition; D016174:Hepacivirus / Q000472:pathogenicity*; D006526:Hepatitis C / Q000150:complications / Q000378:metabolism*; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism
D017382:Reactive Oxygen Species
Hepatitis C virus; chronic liver diseases; hepatocellular carcinoma; oxidative stress; reactive oxygen species