Evaluation of the wound healing efficacy of chemical and phytogenic silver nanoparticles.
Wound healing requires a series of cellular events and a cascade of co-ordinated and systemic biochemical events. Silver nanoparticles possess many beneficial properties for wound management including antibacterial, anti-inflammatory and pro-healing properties. In this study, the authors investigated the wound healing properties ofCinnamomum verumextract mediated nanosilver (CENS) particles in comparison with 1% povidone iodine, citrate mediate NS and CE treatments. The topical application of CENS showed good antibacterial activity and accelerated wound healing with complete epithelialisation and normal re-growth of hair in all three models of study: namely, excision, incision and dead space models in rats compared with all other treatments. CENS was also found to promote collagen synthesis, stabilise wound besides countering oxidative stress and stimulating cellular proliferation CENS could be a novel therapeutic agent for wound management.
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Tirupati 517 502, Andhra Pradesh, India.
Sreevani
S
Pothireddy
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Tirupati 517 502, Andhra Pradesh, India.
Adilaxmamma
A
Kaliki
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Proddatur 516360, Andhra Pradesh, India.
Alpha Raj
AR
Mekapogu
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Proddatur 516360, Andhra Pradesh, India.
Muralidhar
M
Yegireddy
Department of Veterinary Biochemistry, College of Veterinary Science, Tirupati 517 502, Andhra Pradesh, India.
Eswara Prasad
EP
Pagadala
Nanotechnology Centre, Regional Agricultural Research Station, Tirupati 517 502, Andhra Pradesh, India. tnvkvprasad@gmail.com.
Tollamadugu Naga Venkata Krishna Vara
TN
Prasad
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