Efficacy and Safety of LASIK Combined with Accelerated Corneal Collagen Cross-Linking for Myopia: Six-Month Study.
This was a prospective controlled clinical trial. 48 myopia patients (96 eyes) were included in this study. After LASIK, accelerated corneal collagen cross-linking (ACXL) was used for myopia treatment. During 6-month follow-up, the results of LASIK-ACXL treatment were studied and compared to the LASIK-only procedure. The results showed that no statistically significant differences in UDVA, CDVA, MRSE,Kmean, pachymetry, or ECD were found between the two groups at the visit after 6 months of follow-up (allP> 0.05). At 6 months postoperatively, 2 eyes lost one or more lines of visual acuity in the LASIK-ACXL group, whereas all LASIK-only treated eyes had a stable CDVA.In vivoconfocal microscopy showed a decrease of keratocyte density and appearance of honeycomb-like structures in the anterior residual stroma bed; the changes were similar but more pronounced following LASIK-only. None of the cases in both groups developed signs of significant keratitis, regression, or ectasia during the 6-month follow-up. LASIK-ACXL can effectively correct refractive error in patients with myopia, with no significant complications during 6-month follow-up, indicating stability and morphologic change similar to those with LASIK-only treatment.
Department of Ophthalmology, Chinese PLA General Hospital, Beijing 100853, China.
Ying
Y
Wu
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing 100730, China.
Lei
0000-0002-7216-5352
L
Tian
Department of Ophthalmology, Chinese PLA General Hospital, Beijing 100853, China.
Li-Qiang
LQ
Wang
Department of Ophthalmology, Chinese PLA General Hospital, Beijing 100853, China.
Yi-Fei
0000-0002-1078-2515
YF
Huang
Arch Ophthalmol. 2008 Nov;126(11):1484-90
19001213
J Cataract Refract Surg. 2012 Aug;38(8):1424-31
22814049
J Refract Surg. 2012 Nov;28(11):769-76
23347370
Cornea. 2007 Aug;26(7):891-5
17667633
Cornea. 2007 May;26(4):385-9
17457183
Graefes Arch Clin Exp Ophthalmol. 2013 May;251(5):1437-42
23212799
Ophthalmology. 1998 Jul;105(7):1194-9
9663221
J Refract Surg. 2014 Apr;30(4):248-54
24702576
J Refract Surg. 2005 Mar-Apr;21(2):186-90
15796225
J Refract Surg. 2008 Sep;24(7):S748-51
18811123
Clin Ophthalmol. 2012;6:1125-30
22888210
J Refract Surg. 2009 Sep;25(9):S812-8
19772257
J Cataract Refract Surg. 2007 Sep;33(9):1530-8
17720066
Int Ophthalmol Clin. 2013 Winter;53(1):111-28
23221889
J Cataract Refract Surg. 2011 Jan;37(1):149-60
21183110
Acta Ophthalmol. 2013 Jun;91(4):355-62
22512839
J Refract Surg. 2012 Nov;28(11 Suppl):S837-40
23447898
J Cataract Refract Surg. 2014 Jun;40(6):981-90
24857441
J Cataract Refract Surg. 2014 Jun;40(6):1013-20
24857442
Ophthalmology. 2003 Feb;110(2):267-75
12578766
Ophthalmology. 2013 Jul;120(7):1354-9
23582990
J Refract Surg. 2004 Sep-Oct;20(5 Suppl):S718-22
15521275
Am J Ophthalmol. 1998 Apr;125(4):465-71
9559731
J Cataract Refract Surg. 2015 Jan;41(1):41-6
25532633
Int Ophthalmol Clin. 1996 Fall;36(4):45-51
9021459
Curr Opin Ophthalmol. 2006 Aug;17(4):356-60
16900027
Ophthalmologica. 2011;225(2):95-104
20881444