Safety and efficacy of a novel diffractive lens array using a picosecond 755 nm alexandrite laser for treatment of wrinkles.
Picosecond lasers have been reported to be effective for removal of tattoo pigment. This prospective study evaluated the efficacy and safety of the treatment of peri-oral and -ocular wrinkles using a novel diffractive lens array coupled with a picosecond 755 nm alexandrite laser.



Forty female subjects presenting with wrinkles from photodamage were enrolled in an IRB approved study. Subjects received four picosecond diffractive lens array treatments to the full face at 1 month intervals. Six subjects were biopsied (two subjects at 1 month, two subjects at 3 months, and two subjects at 6 months). Digital photographic images were taken at 1, 3, and 6 months post-final treatment visits. Images were graded by blinded physicians for fine lines/wrinkles, erythema, dyschromia, and global improvement. Data on discomfort level, satisfaction, and side effects were recorded.



Overall blinded physician rated global improvement ranged from improved to much improved at 1-, 3-, and 6-month time points. At baseline the average Fitzpatrick wrinkle score was 5.48. At the 6-month follow-up the average score was 3.47. The overall average change in score from pre-treatment to post-treatment was 1.97. Subject self-assessment at 6 months indicated that 90% of subjects were extremely or satisfied with their results. Unanticipated adverse events were absent with anticipated post-treatment erythema lasting for just several hours.



A novel diffractive lens array used with a picosecond 755 nm alexandrite laser for treatment of wrinkles is highly effective and safe for wrinkles and other signs of photoaging. Lasers Surg. Med. 49:40-44, 2017. © 2016 The Authors. Lasers in Surgery and Medicine Published by Wiley Periodicals, Inc.
MD Laser Skin and Vein Institute, Baltimore, Maryland.
Robert A
RA
Weiss
McDaniel Institute, Virginia Beach, Virginia.
David H
DH
McDaniel
MD Laser Skin and Vein Institute, Baltimore, Maryland.
Margaret A
MA
Weiss
MD Laser Skin and Vein Institute, Baltimore, Maryland.
Anne Marie
AM
Mahoney
MD Laser Skin and Vein Institute, Baltimore, Maryland.
Karen L
KL
Beasley
MD Laser Skin and Vein Institute, Baltimore, Maryland.
Christian R
CR
Halvorson
D000328:Adult; D004954:Esthetics; D005260:Female; D006801:Humans; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D028022:Low-Level Light Therapy / Q000379:methods*; D008875:Middle Aged; D017060:Patient Satisfaction; D011446:Prospective Studies; D012060:Rejuvenation; D018570:Risk Assessment; D016037:Single-Blind Method; D015595:Skin Aging / Q000528:radiation effects*; D016896:Treatment Outcome
diffractive lens array; laser; photoaging treatment; picosecond; picosecond laser; prospective clinical trial; skin pigmentation
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