Distribution and characteristics of rodent picornaviruses in China.
Rodents are important reservoir hosts of many important zoonotic viruses. The family Picornaviridae contains clinically important pathogens that infect humans and animals, and increasing numbers of rodent picornaviruses have recently been associated with zoonoses. We collected 574 pharyngeal and anal swab specimens from 287 rodents of 10 different species from eight representative regions of China from October 2013 to July 2015. Seven representative sequences identified from six rodent species were amplified as full genomes and classified into four lineages. Three lineage 1 viruses belonged to a novel genus of picornaviruses and was more closely related to Hepatovirus than to others genera of picornaviruses based on aa homology. Lineage 2, lineage 3, and lineage 4 viruses belonged to the genera Rosavirus, Hunnivirus, and Enterovirus, respectively, representing new species. According to both phylogenetic and identity analyses, Lineage 2 viruses had a close relationship with rosavirus 2 which was recovered from the feces of a child in Gambia and Lineage 3 viruses had a close relationship with domestic animal Hunnivirus. Lineage 4 viruses provide the first evidence of these enteroviruses and their evolution in rodent hosts in China.
MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing, PR China.
Jiang
J
Du
State Key Laboratory for Infectious Diseases Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, PR China.
Liang
L
Lu
MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing, PR China.
Feng
F
Liu
MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing, PR China.
Haoxiang
H
Su
MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing, PR China.
Jie
J
Dong
MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing, PR China.
Lilian
L
Sun
MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing, PR China.
Yafang
Y
Zhu
MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing, PR China.
Xianwen
X
Ren
MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing, PR China.
Fan
F
Yang
MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing, PR China.
Fei
F
Guo
State Key Laboratory for Infectious Diseases Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, PR China.|State Key Laboratory for Infectious Diseases Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, PR China.
Qiyong
Q
Liu
MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing, PR China.|Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, PR China.|State Key Laboratory for Infectious Diseases Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, PR China.
Zhiqiang
Z
Wu
MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing, PR China.|Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, PR China.|State Key Laboratory for Infectious Diseases Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, PR China.
Qi
Q
Jin
Nature. 1987 Jun 11-17;327(6122):482-6
3035380
Arch Virol. 2012 Mar;157(3):525-30
22170478
FEBS Lett. 1990 Mar 12;262(1):145-8
2156730
Virus Res. 1994 Feb;31(2):219-33
7909976
Am J Trop Med Hyg. 1991 Feb;44(2):117-21
1672798
PLoS Pathog. 2011 Sep;7(9):e1002218
21909269
Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15190-5
26575627
Virus Genes. 2005 Mar;30(2):157-80
15744574
J Virol. 1998 Oct;72(10):8408-12
9733894
Curr Opin Microbiol. 2008 Aug;11(4):362-8
18602020
J Virol. 2012 Dec;86(24):13295-302
23015712
Virology. 2014 Apr;454-455:25-33
24725928
Vet Microbiol. 2010 Jan 27;140(3-4):213-20
19748747
J Virol. 2012 Oct;86(20):10999-1012
22855479
Trends Microbiol. 2008 May;16(5):230-7
18420413
J Wildl Dis. 2007 Jan;43(1):12-22
17347389
FEBS Lett. 1989 Jan 30;243(2):103-14
2645167
J Virol. 2011 Sep;85(17):8819-28
21697464
Cell. 2012 Oct 12;151(2):253-66
23063120
MBio. 2015 Aug 25;6(4):null
26307166
Nucleic Acids Res. 1984 Sep 25;12(18):7269-82
6207485
Clin Microbiol Rev. 2007 Jan;20(1):13-22
17223620
J Gen Virol. 2014 May;95(Pt 5):1094-103
24496829
PLoS Pathog. 2009 May;5(5):e1000416
19412527
Emerg Infect Dis. 2010 Jan;16(1):1-7
20031035
Rev Sci Tech. 2004 Aug;23(2):497-511
15702716
Crit Rev Microbiol. 2009;35(3):221-70
19548807
Rev Med Virol. 2011 Jan;21(1):32-41
21294214
Virus Res. 2007 Nov;129(2):104-14
17686542
Nucleic Acids Res. 1989 Jun 26;17 (12 ):4713-30
2546125
Nat Rev Microbiol. 2011 Apr;9(4):254-64
21407242
Mol Ecol. 2009 Jul;18(13):2766-78
19457177
J Virol. 1992 Oct;66(10):6028-34
1326654
ISME J. 2016 Mar;10 (3):609-20
26262818
Infect Dis Clin North Am. 2000 Mar;14(1):167-84, x
10738678
J Virol. 1995 Dec;69(12):8076-8
7494325
FEBS Lett. 1991 Aug 19;288(1-2):201-5
1652473
Science. 1993 Nov 5;262(5135):914-7
8235615
Clin Infect Dis. 2008 Mar 15;46(6):913-8
18260783
J Clin Microbiol. 2007 Nov;45(11):3655-64
17804649
Curr Opin Virol. 2012 Feb;2(1):63-77
22440968
J Gen Virol. 2000 Jan;81(Pt 1):201-7
10640559
MBio. 2014 Oct 14;5(5):e01933-14
25316698
Emerg Infect Dis. 2007 Jan;13(1):6-11
17370509