Transport of haloacids across biological membranes.
Haloacids are considered to be environmental pollutants, but some of them have also been tested in clinical research. The way that haloacids are transported across biological membranes is important for both biodegradation and drug delivery purposes. In this review, we will first summarize putative haloacids transporters and the information about haloacids transport when studying carboxylates transporters. We will then introduce MCT1 and SLC5A8, which are respective transporter for antitumor agent 3-bromopyruvic acid and dichloroacetic acid, and monochloroacetic acid transporters Deh4p and Dehp2 from a haloacids-degrading bacterium. Phylogenetic analysis of these haloacids transporters and other monocarboxylate transporters reveals their evolutionary relationships. Haloacids transporters are not studied to the extent that they deserve compared with their great application potentials, thus future inter-discipline research are desired to better characterize their transport mechanisms for potential applications in both environmental and clinical fields.
Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, PR China. Electronic address: xbsu@sjtu.edu.cn.
Xianbin
X
Su
Shanghai Quality Safety Centre of Agricultural Products, Shanghai 200335, PR China. Electronic address: onlylonely1022@163.com.
Ruihong
R
Li
Molecular Microbiology Laboratory, School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong. Electronic address: kongkf@hku.hk.
Ka-Fai
KF
Kong
Molecular Microbiology Laboratory, School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong. Electronic address: jshtsang@hku.hk.
Jimmy S H
JSH
Tsang
D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D003999:Dichloroacetic Acid / Q000493:pharmacokinetics*; D006801:Humans; D027501:Monocarboxylic Acid Transporters / Q000502:physiology; D010802:Phylogeny; D011773:Pyruvates / Q000493:pharmacokinetics*; D027981:Symporters / Q000502:physiology; D000099233:Monocarboxylate Transport Protein 1
D003999:Dichloroacetic Acid; D027501:Monocarboxylic Acid Transporters; D011773:Pyruvates; D027981:Symporters; D000099233:Monocarboxylate Transport Protein 1; C476760:SLC5A8 protein, human; C017092:bromopyruvate
Carboxylate transporter; Deh4p; Dehp2; Haloacids transporter; MCT1; SLC5A8