Editorial: Statins for Inflammatory Bowel Disease: Expanding the Scope of Prevention.
In addition to cholesterol depletion, statins also significantly decrease systemic inflammation as measured by C-reactive protein. In this issue of American Journal of Gastroenterology, Ungaro et al. present their results on the associations between statin prescriptions and risk of Crohn's disease (CD) and ulcerative colitis (UC). Using a national medical claims and pharmacy database created by Symphony Health Solutions LLC (SHA), they show that any use of statin is protective against diagnosis of CD and UC. The protective effect against CD appears strongest among older populations (>60 years old). These findings offer intriguing insights into inflammatory pathways that could be modulated by cholesterol lowering drugs. In addition, if replicated in other cohorts, these results provide further rationale for investigating the use of statins in broader preventive efforts, including healthy patients at risk of developing inflammatory bowel disease.
Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.|Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Hamed
H
Khalili
D002097:C-Reactive Protein; D003093:Colitis, Ulcerative; D003424:Crohn Disease; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D015212:Inflammatory Bowel Diseases
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D002097:C-Reactive Protein
Inflamm Bowel Dis. 2015 Feb;21(2):361-8
25563694
PLoS Med. 2016 Apr 26;13(4):e1002007
27116322
Int J Mol Med. 2006 Jun;17(6):997-1004
16685407
Dig Dis Sci. 2014 Sep;59(9):2126-35
24781162
Inflamm Bowel Dis. 2015 Nov;21(11):2590-7
26222339
BMJ. 2013 Nov 14;347:f6633
24231178
Ann Intern Med. 2012 Mar 6;156(5):350-9
22393130
Gastroenterology. 2013 Nov;145(5):970-7
23912083
J Clin Epidemiol. 2010 Jan;63(1):64-74
19457638
Gastroenterology. 2012 Nov;143(5):1199-206
22841783
Dig Dis Sci. 2012 Feb;57(2):335-44
21909991
N Engl J Med. 2005 Jan 6;352(1):20-8
15635109
Clin Gastroenterol Hepatol. 2016 Jun;14(6):818-824.e6
26844874
Gut. 2013 Aug;62(8):1153-9
22619368
Atherosclerosis. 2008 Apr;197(2):829-39
17826781
N Engl J Med. 2008 Nov 20;359(21):2195-207
18997196
Aliment Pharmacol Ther. 2016 Jun;43(12):1300-10
27117843
Am J Gastroenterol. 2016 Sep;111(9):1370
27580794