Human case of bacteremia due to Streptococcus suis serotype 5 in Japan: The first report and literature review.
Streptococcus suis is a zoonotic pathogen that can be transferred from pigs to humans. The serotypes 2 and 14 are prevalent among patients with S. suis infections, while other serotypes (i.e., 1, 4, 5, 16, and 24) have been detected in rare human cases. To the best of our knowledge, the present patient handling with raw pork is the first human case of uncomplicated bacteremia due to S. suis serotype 5 in Japan. We confirmed the new sequence type 752 of this isolate. Virulence-associated gene profiling was performed; both sly (encoding the hemolysin suilysin) and mrp (encoding a muramidase-released protein) were detected without amplification of epf (encoding the extracellular factor). Our polymerase chain reaction-based results indicated that this isolate possessed both tet(O), the tetracycline-resistance determinant, and erm(B), the macrolide/lincosamide-resistance determinant. In addition, we provide the review of literature concerning clinical and microbiological features of four human cases of infection due to S. suis serotype 5. Clinicians should be aware of this microorganism when examining and treating patients with fever, who are handling raw pork or having close contact with infected pigs even if they are immunocompetent.
Department of General Internal Medicine, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Daisuke
D
Taniyama
Department of General Internal Medicine, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Mayu
M
Sakurai
Department of General Internal Medicine, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Tetsuya
T
Sakai
Department of Hematology, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Takahide
T
Kikuchi
Laboratory of Infectious Diseases, Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
Takashi
T
Takahashi
Bacteremia; Human case; Japan; Serotype 5; Streptococcus suis
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24719433
Emerg Infect Dis. 2008 Jan;14(1):155-7
18258097
Anim Health Res Rev. 2013 Jun;14(1):68-77
23683342
Emerg Infect Dis. 2011 May;17(5):835-42
21529392
Appl Environ Microbiol. 2010 Dec;76(24):7957-65
20952646
Eur J Clin Microbiol Infect Dis. 2016 Jun;35(6):917-25
26980093
Emerg Infect Dis. 2014 Mar;20(3):500-2
24565286
Lancet. 2011 Sep 3;378(9794):960
21890062
Vet Microbiol. 2006 Jun 15;115(1-3):117-27
16431041
Emerg Infect Dis. 2014 Mar;20(3):489-90
24565084
Antimicrob Agents Chemother. 2005 Nov;49(11):4798-800
16251336
J Med Microbiol. 2014 Jun;63(Pt 6):824-30
24696517
Vet Microbiol. 2013 Mar 23;162(2-4):819-25
23177911