Intentional gaze shift to neglected space: a compensatory strategy during recovery after unilateral spatial neglect.
Unilateral spatial neglect is a common neurological syndrome following predominantly right hemispheric stroke. While most patients lack insight into their neglect behaviour and do not initiate compensatory behaviours in the early recovery phase, some patients recognize it and start to pay attention towards the neglected space. We aimed to characterize visual attention capacity in patients with unilateral spatial neglect with specific focus on cortical processes underlying compensatory gaze shift towards the neglected space during the recovery process. Based on the Behavioural Inattention Test score and presence or absence of experience of neglect in their daily life from stroke onset to the enrolment date, participants were divided into USN++ (do not compensate, n = 15), USN+ (compensate, n = 10), and right hemisphere damage groups (no neglect, n = 24). The patients participated in eye pursuit-based choice reaction tasks and were asked to pursue one of five horizontally located circular objects flashed on a computer display. The task consisted of 25 trials with 4-s intervals, and the order of highlighted objects was randomly determined. From the recorded eye tracking data, eye movement onset and gaze shift were calculated. To elucidate the cortical mechanism underlying behavioural results, electroencephalagram activities were recorded in three USN++, 13 USN+ and eight patients with right hemisphere damage. We found that while lower Behavioural Inattention Test scoring patients (USN++) showed gaze shift to non-neglected space, some higher scoring patients (USN+) showed clear leftward gaze shift at visual stimuli onset. Moreover, we found a significant correlation between Behavioural Inattention Test score and gaze shift extent in the unilateral spatial neglect group (r = -0.62, P < 0.01). Electroencephalography data clearly demonstrated that the extent of increase in theta power in the frontal cortex strongly correlated with the leftward gaze shift extent in the USN++ and USN+ groups. Our results revealed a compensatory strategy (continuous attention to the neglected space) and its neural correlates in patients with unilateral spatial neglect. In conclusion, patients with unilateral spatial neglect who recognized their own neglect behaviour intentionally focused on the neglected space as a compensatory strategy to avoid careless oversight.
Graduate School of Health Science, Kio University, Nara, Japan.|Murata Hospital, Osaka, Japan.
Yusaku
Y
Takamura
Murata Hospital, Osaka, Japan.
Maho
M
Imanishi
Murata Hospital, Osaka, Japan.
Madoka
M
Osaka
Graduate School of Health Science, Kio University, Nara, Japan.|Murata Hospital, Osaka, Japan.
Satoko
S
Ohmatsu
Murata Hospital, Osaka, Japan.
Takanori
T
Tominaga
Graduate School of Human Life Sciences, Showa Women's University, Tokyo, Japan.
Kentaro
K
Yamanaka
Graduate School of Health Science, Kio University, Nara, Japan.|Neurorehabilitation Research Center, Kio University, Nara, Japan.
Shu
S
Morioka
Neurorehabilitation Research Center, Kio University, Nara, Japan.|Department of Rehabilitation for the Movement Functions, Research Institute of National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Saitama, Japan.
Noritaka
N
Kawashima
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002755:Choice Behavior / Q000502:physiology; D003430:Cross-Sectional Studies; D004569:Electroencephalography; D005260:Female; D005403:Fixation, Ocular / Q000502:physiology*; D005625:Frontal Lobe / Q000503:physiopathology; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D033182:Intention; D008297:Male; D008875:Middle Aged; D009039:Motion Perception / Q000502:physiology; D010468:Perceptual Disorders / Q000473:pathology / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology; D020127:Recovery of Function / Q000502:physiology*; D018709:Statistics, Nonparametric; D013826:Theta Rhythm / Q000502:physiology
compensatory strategy; electroencephalography; exogenous attention; phase synchrony; unilateral spatial neglect