Bleomycin-induced skin toxicity: is it always flagellate erythema?
Bleomycin-induced skin toxicity is a rare and unique complication. We report a 35-year-old man with nodular lymphocytic predominant Hodgkin's lymphoma, stage IVB, who was started on adriamycin, bleomycin, vinblastin and dacarbazine (ABVD) chemotherapy. He developed pruritic hyperpigmented, patchy skin lesions on the neck, back, chest and thighs after IA cycle of ABVD chemotherapy. Lesions were not typical flagellate rash but hyperpigmented, patchy and mildly pruritic lesions over the trunk and proximal extremities. Lesions increased with continuation of bleomycin and improved gradually after removing the drug from chemotherapy schedule. The patient was in complete remission after VI cycles of chemotherapy (AVD Regimen) and skin lesions healed with minimal residual hyperpigmentation.
Department of Clinical Haematology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Shailendra Prasad
SP
Verma
Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Arunkumar
A
Subbiah
Department of General Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Vinod
V
Kolar Vishwanath
Department of Clinical Haematology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Tarun Kumar
TK
Dutta
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