Magnetic Resonance Venous Volume Measurements in Peripheral Artery Disease (from ELIMIT).
The relation between the arterial and venous systems in patients with impaired lower extremity blood flow remains poorly described. The objective of this secondary analysis of the Effectiveness of Intensive Lipid Modification Medication in Preventing the Progression on Peripheral Artery Disease Trial was to determine the association between femoral vein (FV) volumes and measurements of peripheral artery disease. FV wall, lumen, and total volumes were quantified with fast spin-echo proton density-weighted magnetic resonance imaging scans in 79 patients with peripheral artery disease over 2 years. Reproducibility was excellent for FV total vessel (intraclass correlation coefficient 0.924, confidence interval 0.910 to 0.935) and lumen volumes (intraclass correlation coefficient 0.893, confidence interval 0.873 to 0.910). Baseline superficial femoral artery volumes were directly associated with FV wall (r = 0.46, p <0.0001), lumen (r = 0.42, p = 0.0001), and total volumes (r = 0.46, p <0.0001). The 2-year change in maximum walking time was inversely associated with the 24-month change in FV total volume (r = -0.45, p = 0.03). In conclusion, FV volumes can be measured reliably with fast spin-echo proton density-weighted magnetic resonance imaging, and baseline superficial femoral artery plaque burden is positively associated with FV volumes, whereas the 2-year change in FV volumes and leg function show an inverse relation.
Division of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, Texas.
Hassan
H
Kamran
Michael E DeBakey VA Medical Center, Houston, Texas; Division of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, Texas; Methodist DeBakey Heart and Vascular Center, Houston Methodist Hospital, Houston, Texas.
Vijay
V
Nambi
Washington Hospital Center, Georgetown University, Washington, District of Columbia.
Smita
S
Negi
Division of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, Texas; Methodist DeBakey Heart and Vascular Center, Houston Methodist Hospital, Houston, Texas.
Eric Y
EY
Yang
Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas.
Changyi
C
Chen
Michael E DeBakey VA Medical Center, Houston, Texas; Division of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, Texas.
Salim S
SS
Virani
Michael E DeBakey VA Medical Center, Houston, Texas.
Panos
P
Kougias
Methodist DeBakey Heart and Vascular Center, Houston Methodist Hospital, Houston, Texas.
Alan B
AB
Lumsden
Division of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, Texas.
Joel D
JD
Morrisett
Division of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, Texas; Methodist DeBakey Heart and Vascular Center, Houston Methodist Hospital, Houston, Texas.
Christie M
CM
Ballantyne
Division of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, Texas; Methodist DeBakey Heart and Vascular Center, Houston Methodist Hospital, Houston, Texas. Electronic address: gbrunner@bcm.edu.
Gerd
G
Brunner
D001810:Blood Volume; D004311:Double-Blind Method; D005260:Female; D005268:Femoral Vein / Q000000981:diagnostic imaging*; D006801:Humans; D007866:Leg / Q000098:blood supply*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000000981:diagnostic imaging*; D015203:Reproducibility of Results; D012307:Risk Factors; D000070857:Walk Test
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