Bone Health in Childhood: Usefulness of Biochemical Biomarkers.
Development of the human skeleton begins in early embryonic life and continues through childhood into early adulthood. The acquisition of peak bone mass during these vulnerable periods may impact on skeletal fragility in later adult years. Once the skeleton has reached maturity, bone remodelling continues with periodic replacement of old bone with new at the same location. Bone biomarkers are specifically derived biomarkers that reflect both formation by osteoblasts and resorption by osteoclasts. Children have significantly higher concentrations of bone biomarkers than adults due to both skeletal growth and rapid bone turnover during childhood and adolescence. Biochemical assessment of markers of bone turnover may be important in the diagnosis, prognosis and management of metabolic bone disease. This review will discuss the various serum bone markers used for assessing bone health and the factors that influence their utility.
Department of Pathology and Molecular Medicine, McMaster University , Hamilton, ON, Canada.
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E
Eapen
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada; Department of Pediatrics, McMaster University, Hamilton, ON, Canada.
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V
Grey
Department of Pathology and Molecular Medicine, McMaster University , Hamilton, ON, Canada.
A
A
Don-Wauchope
Department of Pediatrics, McMaster University , Hamilton, ON, Canada.
S A
SA
Atkinson
Pediatr Blood Cancer. 2008 Feb;50(2 Suppl):479-82; discussion 486
18064644
Endocr Res. 2005;31(3):159-69
16392618
J Clin Endocrinol Metab. 2002 Apr;87(4):1586-92
11932287
Eur J Clin Chem Clin Biochem. 1994 Sep;32(9):675-80
7865622
Am J Clin Nutr. 2004 Oct;80(4):1075-80
15447922
Br J Nutr. 2007 Apr;97(4):661-6
17349078
Clin Biochem. 2006 Jun;39(6):561-8
16423337
Phys Ther. 2006 Jan;86(1):77-91
16386064
J Rheumatol. 2005 Aug;32(8):1556-62
16078334
J Clin Endocrinol Metab. 1998 Sep;83(9):3258-66
9745439
J Nutr. 1995 Jul;125(7):1812-21
7616295
Eur J Nutr. 2004 Dec;43(6):325-35
15309455
Clin Chem. 1990 Jun;36(6):875-8
2357825
Am J Clin Nutr. 1996 Apr;63(4):566-73
8599321
BMJ. 1995 Jun 10;310(6993):1507-10
7787600
Bone. 2003 Aug;33(2):242-7
14499358
Clin Chem. 2002 Feb;48(2):315-22
11805013
Clin Chem. 2005 Dec;51(12):2312-7
16223890
Arch Dis Child. 2002 Oct;87(4):341-7; discussion 341-7
12244017
Bone. 2008 Apr;42(4):623-30
18289953
J Bone Miner Res. 1999 Nov;14(11):1926-33
10571693
Nutr Today. 2002 Mar-Apr;37(2):44-49
11984432
Clin Chim Acta. 1996 Dec 30;256(2):151-64
9027426
Anticancer Res. 1997 Jul-Aug;17(4B):3167-70
9329628
Arch Pediatr Adolesc Med. 2008 Jun;162(6):505-12
18524739
Int J Clin Pract. 1998 Nov-Dec;52(8):557-65
10622055
J Bone Miner Res. 1994 Feb;9(2):135-42
8140926
Clin Orthop Relat Res. 1995 Sep;(318):265-78
7671527
Clin Chem. 1993 Apr;39(4):635-40
8472358
J Bone Miner Metab. 2005;23(2):97-104
15750686
J Bone Miner Metab. 2004;22(2):127-31
14999523
Pediatr Res. 2007 Mar;61(3):366-70
17314699
Arq Bras Endocrinol Metabol. 2006 Aug;50(4):603-20
17117286
Clin Chem. 1996 Nov;42(11):1796-804
8906079
Clin Biochem Rev. 2005 Nov;26(4):97-122
16648882
Crit Rev Clin Lab Sci. 2008;45(2):221-58
18415816
Clin Chem. 1998 Nov;44(11):2281-9
9799755
Bone. 1996 Dec;19(6):645-9
8968032
Proc Nutr Soc. 2006 Nov;65(4):348-60
17181901
Curr Opin Pediatr. 1998 Aug;10(4):441-8
9757372
Cancer Treat Rev. 2006;32 Suppl 1:7-14
16680832
Biochem Biophys Res Commun. 1976 Jul 12;71(1):83-90
183768
Osteoporos Int. 2000;11(4):281-94
10928217
Bone. 2005 Jan;36(1):101-10
15664008
J Clin Endocrinol Metab. 2007 Feb;92 (2):443-9
17105843
Am J Clin Nutr. 2003 Feb;77(2):512-6
12540415
Curr Osteoporos Rep. 2005 Sep;3(3):103-10
16131430
Bone. 2002 Jun;30(6):886-90
12052458
Am J Med. 2006 Apr;119(4 Suppl 1):S25-31
16563938
J Clin Densitom. 2004 Fall;7(3):296-301
15319500
J Clin Endocrinol Metab. 2007 Jun;92(6):2087-99
17311856
J Bone Miner Res. 1997 Jul;12(7):1028-34
9200001
J Bone Miner Metab. 2005;23(6):470-5
16261454