Nucleosome mapping in plasma DNA predicts cancer gene expression.
A new study demonstrates that genomic sequencing coverage of plasma DNA fragments around transcription start sites reflects the expression levels of genes in corresponding tumors. This approach may enable noninvasive monitoring of treatment-induced changes in gene expression for patients with cancer.
Center for Noninvasive Diagnostics, Translational Genomics Research Institute, Phoenix, Arizona, USA, and the Mayo Clinic Center for Individualized Medicine, Scottsdale, Arizona, USA.
Muhammed
0000-0001-7557-2861
M
Murtaza
Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK, and the Cambridge Cancer Centre, Department of Oncology, University of Cambridge, Cambridge, UK.
Carlos
C
Caldas
D004247:DNA / Q000097:blood* / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D015894:Genome, Human; D006801:Humans; D009369:Neoplasms / Q000097:blood / Q000235:genetics*; D009707:Nucleosomes / Q000235:genetics*
D009707:Nucleosomes; D004247:DNA
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