Elevated serum immunoglobulin E level as a marker for progression of immunoglobulin A nephropathy.
BACKGROUND
Immunoglobulin E (IgE) has traditionally been associated with anaphylaxis and atopic disease. Previous studies reported that serum IgE levels are elevated in nephrotic syndrome and suggested IgE levels as a prognostic indicator in glomerular diseases. The aim of this study was to explore the association between serum IgE levels and renal outcome in patients with immunoglobulin A nephropathy (IgAN).


METHODS
We included 117 patients with biopsy-proven IgAN. Renal progression was defined if a patient meets one of these criteria: (1) a negative value of delta estimated glomerular filtration rate (mL/min/1.73 m(2)/mo) or (2) a rise in serum creatinine to an absolute level of ≥ 1.3 mg/dL (male) or 1.2 mg/dL (female). We defined delta changes in serum creatinine, estimated glomerular filtration rate, and proteinuria as a difference of values during the follow-up period.


RESULTS
A total of 117 patients with IgAN were included. The serum IgE level was significantly high in the renal progressive group compared with the nonprogressive group. Sex and history of gross hematuria were significantly different between the high-IgE group and the low-IgE group. Regression analysis showed that a male sex, initial proteinuria, and change of proteinuria were significantly associated with serum IgE levels.


CONCLUSIONS
The serum IgE level is potentially associated with disease progression and pathogenesis of IgAN.
Department of Internal Medicine, Kyung Hee University Medical Center, Seoul, Korea.
Ji-Hoon
JH
Lee
Department of Internal Medicine, Kyung Hee University Medical Center, Seoul, Korea.
Shin Yeong
SY
Lee
Department of Internal Medicine, Kyung Hee University Medical Center, Seoul, Korea.
Jin Sug
JS
Kim
Department of Internal Medicine, Kyung Hee University Medical Center, Seoul, Korea.
Da Rae
da R
Kim
Department of Internal Medicine, Kyung Hee University Medical Center, Seoul, Korea.
Su Woong
SW
Jung
Department of Internal Medicine, Kyung Hee University Medical Center, Seoul, Korea.
Kyung Hwan
KH
Jeong
Department of Internal Medicine, Kyung Hee University Medical Center, Seoul, Korea.
Tae Won
TW
Lee
Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Seoul, Korea.
Yoo Ho
YH
Lee
Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Seoul, Korea.
Yang Gyun
YG
Kim
Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Seoul, Korea.
Ju Young
JY
Moon
Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Seoul, Korea.
Sang Ho
SH
Lee
Department of Internal Medicine, Kyung Hee University Medical Center, Seoul, Korea.
Chun Gyoo
CG
Ihm
Glomerulonephritis; Immunoglobulin A; Immunoglobulin E
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