Effect of TNF-α Blockade in Gingival Crevicular Fluid on Periodontal Condition of Patients with Rheumatoid Arthritis.
BACKGROUND
Periodontitis and rheumatoid arthritis (RA) share a number of clinical and pathologic features, one of which is the presence of the tumor necrosis factor alpha (TNF-α)-induced bone resorption that is involved in the pathogenesis of both.


OBJECTIVE
To investigate the effect of TNF-α blockade on periodontal conditions in patients with active RA.


METHODS
The periodontal statuses of 36 patients (26 females, 10 males) diagnosed with active RA were evaluated both before and after anti-TNF-α therapy. Gingival index, bleeding on probing (BOP), probing pocket depth (PPD), oral hygiene index (OHI), and levels of TNF-α in gingival crevicular fluid (GCF) were measured at the baseline and 6 weeks after the treatment. Wilcoxon signed ranked test was used for statistical analyses.


RESULTS
Based on OHI (p=0.860), the level of plaque control did not change during the study period, but there was a significant reduction in gingival inflammation based on the mean BOP (p=0.049) and GI (p=0.036) before and after 6 weeks of anti-TNF-α therapy. The mean PPD index did not significantly differ at the baseline and 6 weeks after treatment (p=0.126).


CONCLUSIONS
Anti-TNF-α therapy might have a desirable effect on periodontal conditions and might reduce TNF-α level in GCF of patients with RA.
Department of Periodontology, School of Dentistry, Tehran University of Medical Science, Tehran, Iran.
Zeinab
Z
Kadkhoda
Aliakbar
A
Amirzargar
Zahra
Z
Esmaili
Mahdi
M
Vojdanian
Solmaz
S
Akbari
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000628:therapy*; D001862:Bone Resorption / Q000276:immunology / Q000628:therapy*; D005260:Female; D005881:Gingiva / Q000378:metabolism; D005883:Gingival Crevicular Fluid / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology / Q000378:metabolism*
D014409:Tumor Necrosis Factor-alpha