Angiotensin I - Converting Enzyme Gene Polymorphism and Activity in Patients with Ischemic Stroke.
The possible association of ACE polymorphism with ischemic stroke (IS) was evaluated in 65 patients with IS and 330 age and BMI-matched controls. ACE genotypes were determined by polymerase chain reaction (PCR). There was no significant difference in ACE genotype/allele frequencies between case and control group (p>0.05). Patients with D allele had 4,7 times higher risk for large vessel IS than healthy persons D allele possessors. Persons with D allele had 9.2 times higher risk for large vessel disease than small vessel disease. These data suggest a possible association of ACE gene polymorphism with pathogenesis of large vessel IS.
Institute of Medical Biochemistry, Clinical Center of Serbia and Faculty of Pharmacy , Belgrade, Serbia.
Sanja
S
Stankovic
"VINCA" Institute of Nuclear Sciences, Laboratory for Radiobiology and Molecular Genetics , Belgrade, Serbia.
Aleksandra
A
Stankovic
Institute of Cardiovascular Disease, Clinical Center of Serbia , Belgrade, Serbia.
Milika
M
Asanin
Institute of Neurology, Clinical Center of Serbia , Belgrade, Serbia.
Zagorka
Z
Jovanovic-Markovic
"VINCA" Institute of Nuclear Sciences, Laboratory for Radiobiology and Molecular Genetics , Belgrade, Serbia.
Dragan
D
Alavantic
Institute of Medical Biochemistry, Clinical Center of Serbia and Faculty of Pharmacy , Belgrade, Serbia.
Nada
N
Majkic-Singh
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