Minding the Genes: a Multidisciplinary Approach towards Genetic Assessment of Cardiovascular Disease.
Genetic assessment for inherited cardiovascular disease (CVD) is increasingly available, due in part to rapid innovations in genetic sequencing technologies. While genetic testing is aimed at reducing uncertainty, it also produces awareness of potential medical conditions and can leave patients feeling uncertain about their risk, especially if there are ambiguous results. This uncertainty can produce psychological distress for patients and their families undergoing the assessment process. Additionally, patients may experience psychological distress related to living with inherited CVD. In order to more effectively manage the psychosocial challenges related to genetic assessment for CVD, a multidisciplinary model expanded to include psychologists and other allied health professionals is outlined. A case study is provided to illustrate how psychological distress can manifest in a patient living with inherited CVD, as well as proposed psychological management of this patient. Finally, a guide for genetic counselors is provided to aid in identifying and managing common psychological reactions to genetic assessment for CVD.
Department of Psychology, East Carolina University, Greenville, NC, USA.
Ashley
A
Rhodes
Department of Psychology, East Carolina University, Greenville, NC, USA.
Lindsey
L
Rosman
Department of Cardiovascular Sciences, East Carolina University, Greenville, NC, USA.
John
J
Cahill
Agnes Ginges Centre for Molecular Cardiology, Centenary Institute, Newtown, New South Wales, Australia.|Sydney Medical School, University of Sydney, Camperdown, Australia.
Jodie
J
Ingles
Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Brittney
B
Murray
Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Crystal
C
Tichnell
Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Cynthia A
CA
James
Department of Psychology, East Carolina University, Greenville, NC, USA. searss@ecu.edu.|Department of Cardiovascular Sciences, East Carolina University, Greenville, NC, USA. searss@ecu.edu.
Samuel F
SF
Sears
D000328:Adult; D002318:Cardiovascular Diseases / Q000235:genetics* / Q000523:psychology; D005817:Genetic Counseling / Q000379:methods*; D005820:Genetic Testing; D006801:Humans
Cardiovascular disease; Genetic counseling; Multidisciplinary; Psychology
Circ Cardiovasc Genet. 2015 Jun;8(3):437-46
25820315
BMC Psychiatry. 2012 Jul 03;12:73
22759625
Am Heart J. 2005 Aug;150(2):193-201
16086917
JAMA Surg. 2014 Nov;149(11):1109-12
25207883
Heart Rhythm. 2008 May;5(5):719-24
18452877
J Am Coll Cardiol. 2009 Sep 1;54(10):886-90
19712796
Circulation. 2008 Oct 21;118(17):1768-75
18824640
Genet Med. 2008 Feb;10(2):117-20
18281919
Mayo Clin Proc. 2015 Oct;90(10 ):1323-6
26434959
Health Qual Life Outcomes. 2011 Nov 14;9:100
22081957
Europace. 2011 Aug;13(8):1077-109
21810866
Heart Rhythm. 2015 Nov;12(11):2325-31
26144349
Psychosomatics. 2009 Nov-Dec;50(6):613-21
19996233
Am J Med Genet A. 2005 Oct 1;138A(2):107-12
16149070
BMJ Open. 2013 Mar 13;3(3):null
23485718
J Am Coll Cardiol. 2004 Jul 21;44(2):267-71
15261917
Psychooncology. 2013 Apr;22(4):902-10
22740372
Behav Res Ther. 2000 Oct;38(10):1039-53
11004742
Pacing Clin Electrophysiol. 2001 Jul;24(7):1113-7
11475828
Circ Cardiovasc Genet. 2012 Feb 1;5(1):18-24
22238189
World J Pediatr Congenit Heart Surg. 2011 Jul 1;2(3):430-44
23803995
Eur Heart J. 2012 Sep;33(17):2181-8
22613342
J Genet Couns. 2012 Feb;21(1):72-84
21773878
Int J Cardiol. 2015 Feb 15;181:73-6
25482282
Genet Med. 2013 Jul;15(7):565-74
23788249