Impact of hepatitis B virus infection on hepatic metabolic signaling pathway.
A growing body of epidemiologic research has demonstrated that metabolic derangement exists in patients with hepatitis B virus (HBV) infection, indicating that there are clinical associations between HBV infection and host metabolism. In order to understand the complex interplay between HBV and hepatic metabolism in greater depth, we systematically reviewed these alterations in different metabolic signaling pathways due to HBV infection. HBV infection interfered with most aspects of hepatic metabolic responses, including glucose, lipid, nucleic acid, bile acid and vitamin metabolism. Glucose and lipid metabolism is a particular focus due to the significant promotion of gluconeogenesis, glucose aerobic oxidation, the pentose phosphate pathway, fatty acid synthesis or oxidation, phospholipid and cholesterol biosynthesis affected by HBV. These altered metabolic pathways are involved in the pathological process of not only hepatitis B, but also metabolic disorders, increasing the occurrence of complications, such as hepatocellular carcinoma and liver steatosis. Thus, a clearer understanding of the hepatic metabolic pathways affected by HBV and its pathogenesis is necessary to develop more novel therapeutic strategies targeting viral eradication.
Yi-Xian Shi, Chen-Jie Huang, Zheng-Gang Yang, State Key Lab of Diagnostic and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China.
Yi-Xian
YX
Shi
Yi-Xian Shi, Chen-Jie Huang, Zheng-Gang Yang, State Key Lab of Diagnostic and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China.
Chen-Jie
CJ
Huang
Yi-Xian Shi, Chen-Jie Huang, Zheng-Gang Yang, State Key Lab of Diagnostic and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China.
Zheng-Gang
ZG
Yang
D001647:Bile Acids and Salts / Q000737:chemistry; D001786:Blood Glucose / Q000032:analysis; D005234:Fatty Liver / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006515:Hepatitis B virus; D019694:Hepatitis B, Chronic / Q000378:metabolism*; D022781:Hepatocytes / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D053858:Metabolic Networks and Pathways; D009696:Nucleic Acids / Q000032:analysis / Q000737:chemistry; D015398:Signal Transduction; D014815:Vitamins / Q000737:chemistry / Q000378:metabolism
D001647:Bile Acids and Salts; D001786:Blood Glucose; D009696:Nucleic Acids; D014815:Vitamins; D005947:Glucose
Bile acid metabolism; Glucose metabolism; Hepatitis B virus infection; Lipid metabolism; Metabolic derangement; Metabolic signaling pathway; Nucleic acid metabolism; Vitamin metabolism
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