Essential Oil of Thymus munbyanus subsp. coloratus from Algeria: Chemotypification and in vitro Biological Activities.
Thymus munbyanus subsp. coloratus (Lamiaceae) is a small shrub endemic to Algeria and Morocco where is found in lawns, rockeries and mountainous regions. From a phytochemical point of view this taxon has never been characterized. In this work we have analysed the chemical compositions of the essential oils obtained from inflorescences and vegetative parts by GC/MS. A new chemotype, i.e. borneol-chemotype, was characterized for the first time in the species. Furthermore, we assessed the biological activities of essential oils, namely the antioxidant, antimicrobial and cytotoxicity on tumor cells that were evaluated by the DPPH, ABTS, and FRAP, disc diffusion, and MTT methods, respectively. Biological assays highlighted a moderate inhibitory effect on Staphylococcus aureus, Escherichia coli and Candida albicans (inhibition zone diameter in the range 9 - 10 mm), and noteworthy cytotoxicity on A375 human melanoma cells (IC50of 46.95 μg/ml).
Laboratory of Ethnobotany and Natural Substances, Department of Natural Sciences, Ecole Normale Supérieure (ENS), Kouba, B.P N°92 Kouba 16308, Algiers, Algeria.|Natural and Life Sciences Department, Faculty of Sciences, Mohamed Boudiaf University, BP 166 M'sila 28000, M'sila, Algeria.
Hamdi
H
Bendif
Laboratory of Ethnobotany and Natural Substances, Department of Natural Sciences, Ecole Normale Supérieure (ENS), Kouba, B.P N°92 Kouba 16308, Algiers, Algeria.
Messaoud
M
Boudjeniba
Natural and Life Sciences Department, Faculty of Sciences, Mohamed Boudiaf University, BP 166 M'sila 28000, M'sila, Algeria.
Mohamed Djamel
MD
Miara
School of Pharmacy, University of Camerino, via S. Agostino 1, IT-62032, Camerino, Italy.
Loreta
L
Biqiku
School of Pharmacy, University of Camerino, via S. Agostino 1, IT-62032, Camerino, Italy.
Massimo
M
Bramucci
School of Pharmacy, University of Camerino, via S. Agostino 1, IT-62032, Camerino, Italy.
Giulio
G
Lupidi
School of Pharmacy, University of Camerino, via S. Agostino 1, IT-62032, Camerino, Italy.
Luana
L
Quassinti
School of Pharmacy, University of Camerino, via S. Agostino 1, IT-62032, Camerino, Italy.
Luca A
LA
Vitali
School of Pharmacy, University of Camerino, via S. Agostino 1, IT-62032, Camerino, Italy.
Filippo
F
Maggi
D000462:Algeria; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry; D002176:Candida albicans / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D008401:Gas Chromatography-Mass Spectrometry; D019686:Lamiaceae / Q000737:chemistry* / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000032:analysis / Q000737:chemistry* / Q000494:pharmacology*; D035261:Plant Components, Aerial / Q000737:chemistry / Q000378:metabolism; D013211:Staphylococcus aureus / Q000187:drug effects; D046930:Thymus Plant / Q000737:chemistry* / Q000378:metabolism
D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D009822:Oils, Volatile
Antimicrobial; Borneol; Cytotoxic activities; Essential oil; Thymus munbyanus subsp. coloratus