Imaging and Clinical Data of Placental Site Trophoblastic Tumor: A Case Report.
Placental site trophoblastic tumor (PSTT) is a very rare variant of gestational trophoblastic tumor. It can occur after normal termination of pregnancy or spontaneous abortion and ectopic or molar pregnancy. There is a wide range of clinical manifestations from a benign condition to an aggressive disease with fatal outcome. One of the most important characteristics of PSTT, unlike other forms of gestational trophoblastic diseases (GTD) is the presence of low beta-subunit of human chorionic gonadotropin (β-hCG) levels because it is a neoplastic proliferation of intermediate trophoblastic cells. However, human placental lactogen (hPL) is increased on histologic section and in the serum of patients too. We present a case of PSTT and discuss the differential diagnosis in order to further familiarize physicians with the diagnosis and treatment of this disease. It has a varied clinical spectrum and usually presents with irregular vaginal bleeding or amenorrhea. Diagnosis is confirmed by dilatation and curettage (D and C) and hysterectomy. Because chemotherapy is not effective, surgery is the cornerstone of treatment. This case is presented because it is a rare neoplasm with different treatments and it should be differentiated from molar pregnancy.
Department of Reproductive Imaging , Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Maryam
M
Niknejadi
Department of Reproductive Imaging , Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Firoozeh
F
Ahmadi
Department of Reproductive Imaging , Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Farnaz
F
Akhbari
Placental Site Trophoblastic Tumor; Ultrasound
Best Pract Res Clin Obstet Gynaecol. 2003 Dec;17(6):969-84
14614893
Cancer. 2002 Apr 15;94(8):2288-94
12001129
Int J Gynecol Cancer. 2004 May-Jun;14 (3):558-63
15228435
J Cancer Res Clin Oncol. 2008 Jan;134(1):1-6
17701427
Am J Nurs. 2009 Dec;109(12):32-7; quiz 38
19935163
Clin Cancer Res. 1996 May;2(5):897-902
9816247
Radiat Med. 1999 Nov-Dec;17 (6):427-30
10646979
Obstet Gynecol Surv. 2003 Jul;58(7):484-8
12832940
Lab Invest. 2000 Jun;80(6):965-72
10879746
Hum Pathol. 1998 Jan;29(1):27-33
9445130
APMIS Suppl. 1991;23:138-45
1652995
Gynecol Oncol. 2006 Aug;102(2):160-4
16631918
Cancer. 1976 Sep;38(3):1214-26
182351
Int J Gynecol Cancer. 1995 Jan;5(1):64-70
11578456
J Reprod Med. 1998 Jan;43(1):53-9
9475150