Relationship Between Two Common Lipoprotein Lipase Variants and the Metabolic Syndrome and Its Individual Components.
Common lipoprotein lipase (LPL) variants are important determinants of triglycerides (TG) and high-density lipoprotein (HDL) cholesterol (C) concentrations. High TG/low HDL-C tend to cluster with hypertension, glucose intolerance, and abdominal obesity and comprise the metabolic syndrome (MetS). The role of LPL variants as a cause of MetS is unclear. This study investigated the relationship between two common LPL variants and the presence of MetS and its individual components.



Cross-sectional study, including 2348 Danish women (50.7%) and men, age 41-72 years, without known cardiovascular disease. Carrier status for the two common LPL variants: 447Ter (low TG/high HDL-C) and 291Ser (high TG/low HDL-C) was determined. The prevalence of MetS according to the National Cholesterol Education Program criteria was 16.6%.



Of the 2348 participants, 19.8% had the 447Ter variant and 4.9% had the 291Ser variant. Compared with the reference variant, the prevalence of MetS was lower in carriers of the 447Ter variant (11.2% vs. 17.9%, P < 0.001) but with no difference in carriers of the 291Ser variant (18.4% vs. 16.5%, P = 0.59). Adjusted for age, sex, smoking, physical activity, alcohol consumption, and highest sex-specific insulin quartile, the relative risk of MetS was 0.63 (95% confidence interval [CI] 0.45-0.89, P < 0.01) for carriers of the 447Ter variant and 1.20 (95% CI 0.70-2.03, P > 0.05) for carriers of the 291Ser variant. Both LPL variants were associated with high TG/low HDL-C (P < 0.01), but not with the MetS components waist circumference, hypertension, and glucose intolerance (P > 0.05).



The two common LPL variants were associated with MetS through their effect on high TG/low HDL-C.
1 Research Centre for Prevention and Health, Glostrup Hospital, University of Copenhagen , Glostrup, Denmark .|2 Department of Internal Medicine, Næstved Hospital, University of Copenhagen , Næstved, Denmark .
Julie K K
JK
Vishram
3 Steno Diabetes Center , Gentofte, Denmark .
Tine W
TW
Hansen
4 Department of Health, Science and Technology, Aalborg University , Aalborg, Denmark .
Christian
C
Torp-Pedersen
5 Faculty of Health Sciences, University of Copenhagen , Copenhagen, Denmark .|6 Department of Endocrinology and Internal Medicine, Hvidovre Hospital, University of Copenhagen , Hvidovre, Denmark .
Sten
S
Madsbad
1 Research Centre for Prevention and Health, Glostrup Hospital, University of Copenhagen , Glostrup, Denmark .|5 Faculty of Health Sciences, University of Copenhagen , Copenhagen, Denmark .
Torben
T
Jørgensen
5 Faculty of Health Sciences, University of Copenhagen , Copenhagen, Denmark .|7 Department of Clinical Biochemistry, Hvidovre Hospital, University of Copenhagen , Hvidovre, Denmark .
Mogens
M
Fenger
8 Department of Medicine, Glostrup Hospital, University of Copenhagen , Glostrup, Denmark .
Stig
S
Lyngbæk
5 Faculty of Health Sciences, University of Copenhagen , Copenhagen, Denmark .|8 Department of Medicine, Glostrup Hospital, University of Copenhagen , Glostrup, Denmark .
Jørgen
J
Jeppesen
D000328:Adult; D000368:Aged; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D003718:Denmark / Q000453:epidemiology; D005260:Female; D056726:Genetic Association Studies; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D008071:Lipoprotein Lipase / Q000235:genetics*; D008297:Male; D024821:Metabolic Syndrome / Q000201:enzymology* / Q000453:epidemiology / Q000235:genetics*; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D007527:Isoenzymes; D014280:Triglycerides; C548261:LPL protein, human; D008071:Lipoprotein Lipase
lipids; lipoprotein lipase; metabolic syndrome; variants