Effects of initiating moderate wine intake on abdominal adipose tissue in adults with type 2 diabetes: a 2-year randomized controlled trial.
To generate evidence-based conclusions about the effect of wine consumption on weight gain and abdominal fat accumulation and distribution in patients with type 2 diabetes.



In the 2-year randomized controlled CASCADE (CArdiovaSCulAr Diabetes & Ethanol) trial, patients following a Mediterranean diet were randomly assigned to drink 150 ml of mineral water, white wine or red wine with dinner for 2 years. Visceral adiposity and abdominal fat distribution were measured in a subgroup of sixty-five participants, using abdominal MRI.



Ben-Gurion University of the Negev, Soroka-Medical Center and the Nuclear Research Center Negev, Israel.



Alcohol-abstaining adults with well-controlled type 2 diabetes.



Forty-eight participants (red wine, n 27; mineral water, n 21) who completed a second MRI measurement were included in the 2-year analysis. Similar weight losses (sd) were observed: red wine 1·3 (3·9) kg; water 1·0 (4·2) kg (P=0·8 between groups). Changes (95 % CI) in abdominal adipose-tissue distribution were similar: red wine, visceral adipose tissue (VAT) -3·0 (-8·0, 2·0) %, deep subcutaneous adipose tissue (DSAT) +5·2 (-1·1, 11·6) %, superficial subcutaneous adipose tissue (SSAT) -1·9 (-5·0, 1·2) %; water, VAT -3·2 (-8·9, 2·5) %, DSAT +2·9 (-2·8, 8·6) %, SSAT -0·15 (-3·3, 2·9) %. No changes in antidiabetic medication and no substantial changes in energy intake (+126 (sd 2889) kJ/d (+30·2 (sd 690) kcal/d), P=0·8) were recorded. A 2-year decrease in glycated Hb (β=0·28, P=0·05) was associated with a decrease in VAT.



Moderate wine consumption, as part of a Mediterranean diet, in persons with controlled diabetes did not promote weight gain or abdominal adiposity.
1Department of Public Health, Faculty of Health Sciences,Ben-Gurion University of the Negev,PO Box 653,Beer-Sheva 84105,Israel.
Rachel
R
Golan
2Soroka University Medical Center,Beer-Sheva,Israel.
Ilan
I
Shelef
2Soroka University Medical Center,Beer-Sheva,Israel.
Elad
E
Shemesh
2Soroka University Medical Center,Beer-Sheva,Israel.
Yaakov
Y
Henkin
3Nuclear Research Center Negev,Dimona,Israel.
Dan
D
Schwarzfuchs
1Department of Public Health, Faculty of Health Sciences,Ben-Gurion University of the Negev,PO Box 653,Beer-Sheva 84105,Israel.
Yftach
Y
Gepner
2Soroka University Medical Center,Beer-Sheva,Israel.
Ilana
I
Harman-Boehm
1Department of Public Health, Faculty of Health Sciences,Ben-Gurion University of the Negev,PO Box 653,Beer-Sheva 84105,Israel.
Shula
S
Witkow
1Department of Public Health, Faculty of Health Sciences,Ben-Gurion University of the Negev,PO Box 653,Beer-Sheva 84105,Israel.
Michael
M
Friger
2Soroka University Medical Center,Beer-Sheva,Israel.
Yoash
Y
Chassidim
2Soroka University Medical Center,Beer-Sheva,Israel.
Idit F
IF
Liberty
3Nuclear Research Center Negev,Dimona,Israel.
Benjamin
B
Sarusi
1Department of Public Health, Faculty of Health Sciences,Ben-Gurion University of the Negev,PO Box 653,Beer-Sheva 84105,Israel.
Dana
D
Serfaty
1Department of Public Health, Faculty of Health Sciences,Ben-Gurion University of the Negev,PO Box 653,Beer-Sheva 84105,Israel.
Nitzan
N
Bril
1Department of Public Health, Faculty of Health Sciences,Ben-Gurion University of the Negev,PO Box 653,Beer-Sheva 84105,Israel.
Michal
M
Rein
1Department of Public Health, Faculty of Health Sciences,Ben-Gurion University of the Negev,PO Box 653,Beer-Sheva 84105,Israel.
Noa
N
Cohen
1Department of Public Health, Faculty of Health Sciences,Ben-Gurion University of the Negev,PO Box 653,Beer-Sheva 84105,Israel.
Sivan
S
Ben-Avraham
4Department of Medicine,University of Leipzig,Leipzig,Germany.
Uta
U
Ceglarek
4Department of Medicine,University of Leipzig,Leipzig,Germany.
Michael
M
Stumvoll
4Department of Medicine,University of Leipzig,Leipzig,Germany.
Matthias
M
Blüher
4Department of Medicine,University of Leipzig,Leipzig,Germany.
Joachim
J
Thiery
5Channing Division of Network Medicine,Department of Medicine,Brigham and Women's Hospital and Harvard School of Public Health,Boston,MA,USA.
Meir J
MJ
Stampfer
1Department of Public Health, Faculty of Health Sciences,Ben-Gurion University of the Negev,PO Box 653,Beer-Sheva 84105,Israel.
Assaf
A
Rudich
1Department of Public Health, Faculty of Health Sciences,Ben-Gurion University of the Negev,PO Box 653,Beer-Sheva 84105,Israel.
Iris
I
Shai
D050153:Abdominal Fat / Q000503:physiopathology*; D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000178:diet therapy* / Q000503:physiopathology; D038441:Diet, Mediterranean; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D050152:Intra-Abdominal Fat / Q000503:physiopathology; D008297:Male; D062407:Meals; D050151:Subcutaneous Fat / Q000503:physiopathology; D015430:Weight Gain / Q000502:physiology; D014920:Wine / Q000009:adverse effects*
D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human
Abdominal adipose tissue; MRI; Mediterranean diet; Type 2 diabetes; Wine
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