LTD-like molecular pathways in developmental synaptic pruning.
In long-term depression (LTD) at synapses in the adult brain, synaptic strength is reduced in an experience-dependent manner. LTD thus provides a cellular mechanism for information storage in some forms of learning. A similar activity-dependent reduction in synaptic strength also occurs in the developing brain and there provides an essential step in synaptic pruning and the postnatal development of neural circuits. Here we review evidence suggesting that LTD and synaptic pruning share components of their underlying molecular machinery and may thus represent two developmental stages of the same type of synaptic modulation that serve different, but related, functions in neural circuit plasticity. We also assess the relationship between LTD and synaptic pruning in the context of recent findings of LTD dysregulation in several mouse models of autism spectrum disorder (ASD) and discuss whether LTD deficits can indicate impaired pruning processes that are required for proper brain development.
Department of Neurobiology, University of Chicago, Chicago, Illinois, USA.|Department of Physiology, Northwestern University, Chicago, Illinois, USA.
Claire
C
Piochon
Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Masanobu
M
Kano
Department of Neurobiology, University of Chicago, Chicago, Illinois, USA.
Christian
C
Hansel
D000818:Animals; D000067877:Autism Spectrum Disorder / Q000503:physiopathology*; D001921:Brain / Q000254:growth & development* / Q000502:physiology; D004195:Disease Models, Animal; D006801:Humans; D036881:Long-Term Synaptic Depression / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*
Cerebellum. 2012 Sep;11(3):777-807
22370873
Neuron. 2004 Nov 18;44(4):585-94
15541307
Neuron. 2010 Apr 29;66(2):191-7
20434996
Mol Autism. 2013 May 22;4(1):14
23697635
Nature. 2011 Nov 23;480(7375):63-8
22113615
Nat Commun. 2013;4:2732
24225482
Science. 1991 Nov 15;254(5034):1019-22
1658939
Neuron. 2014 Sep 3;83(5):1131-43
25155956
Proc Natl Acad Sci U S A. 2002 May 28;99(11):7746-50
12032354
Cell Rep. 2014 Aug 21;8(4):1119-29
25127140
J Neurosci. 2013 May 1;33(18):7641-53
23637158
Neuron. 2009 Jul 16;63(1):106-18
19607796
Nat Commun. 2014 Nov 24;5:5586
25418414
Eur J Neurosci. 1997 Nov;9(11):2309-22
9464925
Neuron. 2005 Aug 4;47(3):339-52
16055059
Nature. 2013 Jan 17;493(7432):411-5
23263185
Neuron. 2013 Jun 19;78(6):1024-35
23791196
J Neurosci. 2010 Nov 10;30(45):14964-71
21068299
Science. 1987 Oct 16;238(4825):355-8
2443978
Science. 2011 Sep 9;333(6048):1456-8
21778362
Neuron. 1999 Apr;22(4):763-75
10230796
J Neurosci. 2013 May 29;33(22):9546-62
23719821
Eur J Neurosci. 2003 Feb;17(3):545-54
12581172
J Neurosci. 2006 Feb 15;26(7):1906-12
16481422
Science. 1997 Jan 17;275(5298):356-61
8994026
Neuron. 1996 Apr;16(4):745-54
8607993
Eur J Neurosci. 2007 Mar;25(5):1460-6
17425571
Neuron. 2004 Dec 2;44(5):759-67
15572108
Proc Natl Acad Sci U S A. 1997 May 13;94(10):5401-4
9144249
Science. 1999 Apr 2;284(5411):162-6
10102820
J Neurosci. 2008 Jan 23;28(4):798-807
18216188
Mol Neurobiol. 2001 Feb;23(1):69-82
11642544
Nature. 1994 Dec 8;372(6506):519-24
7990923
J Neurosci. 1990 Mar;10(3):909-25
1969466
J Neurosci. 1994 May;14(5 Pt 1):2830-43
8182442
J Neurosci. 1982 Jan;2(1):32-48
7054394
J Physiol. 2007 Nov 15;585(Pt 1):91-101
17901118
J Neurosci. 1994 May;14(5 Pt 2):3404-12
8182481
Neuron. 2007 Dec 20;56(6):955-62
18093519
J Neurosci. 2015 Nov 11;35(45):15073-81
26558778
J Physiol. 1970 Aug;209(3):701-9
5499804
Neurobiol Dis. 2013 Mar;51:93-103
23123587
Neuron. 2015 Aug 19;87(4):699-715
26291156
Neuroreport. 1997 Jan 20;8(2):571-4
9080450
J Neurosci. 2007 Oct 3;27(40):10797-809
17913913
Prog Brain Res. 2014;210:1-30
24916287
Nat Rev Neurosci. 2005 Nov;6(11):877-88
16261181
Nature. 1987 Dec 17-23;330(6149):649-52
2446147
Neuron. 2012 Apr 26;74(2):384-96
22542190
Science. 1995 Nov 3;270(5237):758-64
7481762
Eur J Neurosci. 2008 Dec;28(12):2393-400
19032589
Neuron. 2000 May;26(2):473-82
10839365
J Neurophysiol. 1963 Nov;26:978-93
14084170
Nature. 1995 Mar 16;374(6519):262-6
7885445
Neuropsychologia. 1990;28(6):517-27
2203993
JAMA. 2003 Jul 16;290(3):337-44
12865374
Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7168-71
8102206
Annu Rev Neurosci. 2007;30:79-97
17280523
Nat Rev Neurosci. 2009 Sep;10(9):647-58
19693029
Science. 2003 Jun 13;300(5626):1751-5
12805550
Science. 2012 Oct 5;338(6103):128-32
22983708
J Physiol. 2004 Sep 1;559(Pt 2):507-17
15243135
Annu Rev Physiol. 2009;71:261-82
19575680
J Neurosci. 2015 Aug 05;35(31):11125-32
26245973
Nature. 1993 Jun 24;363(6431):722-4
8515814
Nat Neurosci. 2011 Mar;14(3):285-93
21346746
Annu Rev Neurosci. 2001;24:1071-89
11520928
Neuron. 2015 Aug 19;87(4):781-96
26291161
Neuron. 2003 Jun 5;38(5):785-96
12797962
Neuron. 2006 Sep 21;51(6):835-43
16982427
J Physiol. 2008 Mar 15;586(6):1503-8
18202092
J Clin Invest. 2015 Nov 2;125(11):4305-15
26485287
J Neurosci. 1994 Aug;14(8):4694-704
8046444
Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4510-9
24191047
Front Neurosci. 2007 Oct 15;1(1):77-96
18982120
Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7975-80
20375278
Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2282-7
26858447
Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12852-7
26417096
Neuron. 2015 Jan 21;85(2):316-29
25611509
Neuron. 2006 Oct 19;52(2):227-38
17046686
Cell. 1994 Oct 21;79(2):377-88
7954803
Science. 2000 Jun 9;288(5472):1832-5
10846166
Mol Psychiatry. 2014 Jun;19(6):659-67
23774715
Trends Neurosci. 2004 Jul;27(7):370-7
15219735
Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):14089-94
9391157
J Autism Dev Disord. 1994 Dec;24(6):737-51
7844097
Proc Natl Acad Sci U S A. 1973 Apr;70(4):997-1001
4352227
Sci Signal. 2014 Oct 28;7(349):re10
25351249
Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9987-92
21628556
Neuroscience. 2009 Sep 1;162(3):601-11
19166909
Science. 1999 Sep 10;285(5434):1725-8
10481007
J Physiol. 2000 Jun 1;525 Pt 2:299-305
10835034
Neuron. 1998 Mar;20(3):495-508
9539124
J Neurosci. 1993 Feb;13(2):834-55
8426240
Cold Spring Harb Perspect Biol. 2012 Mar 01;4(3):
22258914
Nat Rev Neurosci. 2012 Nov;13(11):798-810
23080416
Prog Brain Res. 2013;207:3-34
24309249
Neurosci Res. 2004 Nov;50(3):361-7
15488299
J Neurosci. 2010 Nov 10;30(45):15330-5
21068337
J Physiol. 2013 Apr 1;591(7):1707-30
23297306
Nat Neurosci. 2002 Aug;5(8):725-6
12134155
Neuron. 2014 Aug 6;83(3):518-32
25102558
Neuron. 1997 Jan;18(1):71-9
9010206
Front Neural Circuits. 2021 Jun 28;15:676891
34262438
Philos Trans R Soc Lond B Biol Sci. 2008 Jun 27;363(1500):2173-86
18339599
Neuron. 2004 Dec 2;44(5):749-57
15572107
Neuroscience. 2013 Sep 17;248:708-18
23769889
Brain. 2009 Sep;132(Pt 9):2413-25
19389870
J Neurosci. 2005 Nov 16;25(46):10768-72
16291950
Brain Res. 2015 Sep 24;1621:260-9
25289586
Nat Neurosci. 2011 Mar;14(3):279-84
21278731
Cell. 1995 Dec 29;83(7):1233-42
8548809
J Neurosci. 2012 Oct 24;32(43):15106-11
23100431
Nat Rev Genet. 2008 May;9(5):341-55
18414403
Cell Mol Life Sci. 2013 Dec;70(24):4667-80
23811844
Science. 1991 Dec 13;254(5038):1656-9
1721243
Nature. 2002 Dec 19-26;420(6917):788-94
12490942
Nat Neurosci. 2010 Sep;13(9):1082-9
20694003
Cerebellum. 2002 Jan-Mar;1(1):19-26
12879970
Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15724-9
9861037
Nature. 2005 Jul 14;436(7048):261-5
16015331
Nat Rev Neurosci. 2012 Sep;13(9):619-35
22895474
J Physiol. 2014 Jan 1;592(1):13-31
24144877
Nat Neurosci. 2001 May;4(5):467-75
11319554
J Neurosci. 2000 Jul 1;20(13):4954-61
10864953
Neuron. 2012 Jun 7;74(5):816-29
22681687
Trends Neurosci. 1993 Dec;16(12):521-7
7509523
Cell. 1995 Dec 29;83(7):1223-31
8548808
Cell Rep. 2013 Nov 14;5(3):738-47
24210821
J Neurobiol. 1976 Nov;7(6):567-78
1003202
Science. 1992 Jun 26;256(5065):1823-5
1352066
J Neurobiol. 1999 Oct;41(1):83-91
10504195
J Neurophysiol. 2008 Dec;100(6):3167-74
18922952
Nature. 2012 Aug 30;488(7413):647-51
22763451
Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):676-81
14699042
J Neurosci. 2004 Jun 2;24(22):5119-30
15175381
Curr Opin Neurobiol. 2012 Jun;22(3):522-9
22409856
Nat Neurosci. 2014 Mar;17(3):400-6
24487234
Brain Res. 2010 Jan 14;1309:83-94
19896929
Science. 2015 Nov 20;350(6263):
26472761
PLoS Biol. 2012;10(6):e1001352
22745601
Nat Neurosci. 2003 Aug;6(8):854-62
12886226
Neuron. 2005 Jan 20;45(2):279-91
15664179
Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E188-93
24367085
J Neurosci. 1990 Jul;10(7):2156-75
2376772
Nature. 1994 Nov 17;372(6503):237-43
7969468
Nature. 1999 Jan 28;397(6717):347-50
9950426
Science. 1993 Jun 4;260(5113):1518-21
8502997