Empirical modeling of metabolic alkalosis induced by sodium bicarbonate ingestion.
Biphasic responses of blood HCO3-concentration and H+concentration following ingestion of 3 doses of NaHCO3(0.1, 0.2, 0.3 g·kg-1) were assessed in 8 men. For HCO3-concentration, there were significant effects of dose on maximum responses and timing, as well amplitudes, onsets, and/or time constants of phases 1 and 2. Fewer significant effects of dose were observed for H+concentration and additional data demonstrated differential effects of dose on HCO3-concentration and H+concentration responses and underlying phases.
a School of Science and Health, Western Sydney University, Sydney 2751, Australia.|b School of Medicine, Western Sydney University, Sydney 2751, Australia.
Simon
S
Green
a School of Science and Health, Western Sydney University, Sydney 2751, Australia.
Jason C
JC
Siegler
alcali; alcalose; alkali; alkalosis; amplitude; dose; décours temporel; estimation paramétrique; magnitude; parameter estimation; timecourse