Regional tumour glutamine supply affects chromatin and cell identity.
Limited perfusion of solid tumours produces a nutrient-deprived tumour core microenvironment. Low glutamine levels in the tumour core are now shown to lead to reduced levels of α-ketoglutarate and decreased histone demethylase activity, thereby promoting a less differentiated and more therapy-resistant state of the tumour cells.
Biotech Research and Innovation Centre, University of Copenhagen, 2200, Denmark; at the Centre for Epigenetics, University of Copenhagen, 2200, Denmark; and at the Danish Stem Cell Center (Danstem), Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Denmark.
Jonas W
JW
Højfeldt
Biotech Research and Innovation Centre, University of Copenhagen, 2200, Denmark; at the Centre for Epigenetics, University of Copenhagen, 2200, Denmark; and at the Danish Stem Cell Center (Danstem), Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Denmark.
Kristian
K
Helin
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects* / Q000502:physiology; D002843:Chromatin / Q000187:drug effects / Q000378:metabolism*; D005973:Glutamine / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D007656:Ketoglutaric Acids / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D059016:Tumor Microenvironment / Q000187:drug effects* / Q000502:physiology
D002843:Chromatin; D007656:Ketoglutaric Acids; D005973:Glutamine
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