Two new limonoids isolated from the fuits of Melia toosendan.
In the present study, two new limonoids, 1α, 7α-dihydroxyl-3α-acetoxyl-12α-ethoxylnimbolinin (1) and 1α-tigloyloxy-3α-acetoxyl-7α-hydroxyl-12β-ethoxylnimbolinin (2), together with other four known limonoids (3-6), were isolated from the fruits of Melia toosendan. Their structures were elucidated by means of extensive spectroscopic analyses (NMR and ESI-MS) and comparisons with the data reported in the literature. The isolated compounds were evaluated for their antibacterial activities. Compound 4 exhibited significant antibacterial activity against an oral pathogen, Porphyromonas gingivalis ATCC 33277, with an MIC value of 15.2 μg·mL(-1). Compound 2 was also active against P. gingivalis ATCC 33277, with an MIC value of 31.25 μg·mL(-1). In conlcusion, our resutls indicate that these compounds may provide a basis for future development of novel antibiotics.
Department of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China. Electronic address: zhangqiong_83@hotmail.com.
Qiong
Q
Zhang
Department of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China.
Qing-Hong
QH
Zheng
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Jing-Yu
JY
Liang
Department of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China.
Qing-Shan
QS
Li
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Zhi-Da
ZD
Min
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D005638:Fruit / Q000737:chemistry; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D031585:Melia / Q000737:chemistry*; D015394:Molecular Structure; D016966:Porphyromonas gingivalis / Q000187:drug effects / Q000254:growth & development; D021241:Spectrometry, Mass, Electrospray Ionization
D000900:Anti-Bacterial Agents; D004365:Drugs, Chinese Herbal; D036701:Limonins
Antibacterial; Limonoid; Melia toosendan; Meliaceae; Oral pathogen