Changes of grey matter volume in first-episode drug-naive adult major depressive disorder patients with different age-onset.
OBJECTIVE
Little is known about the pathological mechanism of early adult onset depression (EOD) and later adult onset depression (LOD). We seek to determine whether grey matter volume (GMV) change in EOD and LOD are different, which could also delineate EOD and LOD.


METHODS
In present study, 147 first-episode, drug-naive patients with major depressive disorder (MDD), age between 18 and 45, were divided into two groups on the basis of age of MDD onset: the early adult onset group (age 18-29) and the later adult onset group (age 30-44), and a total of 130 gender-, and age-, matched healthy controls (HC) were also divided into two groups which fit for each patient group. Magnetic resonance imaging was conducted on all subjects. The voxel-based morphometry (VBM) approach was employed to analyze the images.


RESULTS
Widespread abnormalities of GMV throughout parietal, temporal, limbic regions, occipital cortex and cerebellum were observed in MDD patients. Compare to young HC, reduced GMV in right fusiform gyrus, right middle temporal gyrus, vermis III and increased GMV in right middle occipital gyrus were seen in the EOD group. In contrast, relative to old HC, decreased GMV in the right hippocampus and increased GMV in the left middle temporal gyrus were observed in the LOD group. Compared to the LOD group, the EOD group had smaller GMV in right posterior cingulate cortex. There was no significant correlation between GMV of the right posterior cingulate cortex and the score of the depression rating scale in patients group.


CONCLUSIONS
The GMV of the brain areas that were related to mood regulation was decreased in the first-episode, drug-naive adult patients with MDD. Adult patients with EOD and LOD exhibited different GMV changes relative to each age-matched comparison group, suggesting depressed adult patients with different age-onset might have different pathological mechanism.
Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
Zonglin
Z
Shen
Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
Yuqi
Y
Cheng
Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
Shuran
S
Yang
Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
Nan
N
Dai
Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
Jing
J
Ye
Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
Xiaoyan
X
Liu
Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
Jin
J
Lu
Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
Na
N
Li
Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
Fang
F
Liu
Department of Medical Imaging, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
Yi
Y
Lu
Department of Medical Imaging, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
Xuejin
X
Sun
Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
Xiufeng
X
Xu
Different age at onset; Grey matter volume; Magnetic resonance imaging; Major depressive disorder
Arch Gen Psychiatry. 2005 Jun;62(6):593-602
15939837
JAMA. 2003 Jun 18;289(23):3095-105
12813115
Prog Neuropsychopharmacol Biol Psychiatry. 2012 Jan 10;36(1):11-6
22001316
J Affect Disord. 2012 May;138(3):259-67
22370067
J Cogn Neurosci. 2013 Mar;25(3):421-35
23092213
Br J Psychiatry. 2004 Jun;184:488-95
15172942
Transl Psychiatry. 2016 Apr 26;6:e790
27115121
Soc Cogn Affect Neurosci. 2009 Mar;4(1):59-69
19015088
PLoS One. 2014 Nov 13;9(11):e112307
25393297
Psychiatry Clin Neurosci. 2009 Dec;63(6):754-61
20021629
Neurosci Biobehav Rev. 2015 Sep;56:330-44
26234819
Psychol Med. 2008 May;38(5):641-9
18272011
Am J Psychiatry. 2006 Sep;163(9):1554-60
16946180
Neuroscience. 2001;104(3):667-76
11440800
Nat Rev Neurosci. 2002 Mar;3(3):201-15
11994752
Int J Geriatr Psychiatry. 2013 Nov;28(11):1166-74
23420677
Cogn Affect Behav Neurosci. 2009 Dec;9(4):434-47
19897796
Eur J Radiol. 2011 Nov;80(2):450-4
20634013
Neuroreport. 2015 Jan 21;26(2):57-65
25494472
J Affect Disord. 2012 Jul;139(2):126-40
21885128
Biol Psychiatry. 2011 Aug 15;70(4):308-9
21791257
Front Hum Neurosci. 2015 Jun 02;9:318
26082708
Neuropsychologia. 2012 Jul;50(9):2348-55
22714007
Psychiatry Res. 2013 Jan 30;211(1):37-46
23146253
Neuroreport. 2014 Nov 12;25(16):1302-7
25229945
Neuroimage Clin. 2013 Sep 06;3:332-9
24273717
Am J Psychiatry. 2004 Nov;161(11):1957-66
15514393
Eur J Radiol. 2011 Nov;80(2):395-9
20466498
PLoS One. 2012;7(10):e48658
23119084
Yonsei Med J. 2014 Nov;55(6):1712-20
25323911
J Affect Disord. 2008 Oct;110(3):241-7
18321593
Cereb Cortex. 2011 Sep;21(9):2003-13
21282318
J Psychiatry Neurosci. 2009 Jan;34(1):41-54
19125212
Arch Gen Psychiatry. 1998 May;55(5):468-72
9596050
Schizophr Res. 2015 May;164(1-3):74-82
25687531
Arch Gen Psychiatry. 1984 Dec;41(12):1136-43
6508504
Mol Psychiatry. 2016 Jun;21(6):806-12
26122586
Int J Geriatr Psychiatry. 2004 Jul;19(7):701-3
15254929
Neuroimage. 2010 Mar;50(1):347-56
19931620
Hum Brain Mapp. 2009 Feb;30(2):625-37
18219617
J Affect Disord. 2012 Apr;138(1-2):9-18
21511342
Clin Pract Epidemiol Ment Health. 2011;7:140-7
21866230
Brain. 1998 Apr;121 ( Pt 4):545-6
9577383
Brain Res. 2016 Sep 1;1646:152-9
27235864
Am J Psychiatry. 2000 Oct;157(10):1552-62
11007705
Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):253-8
12506194
J Am Acad Child Adolesc Psychiatry. 2015 Oct;54(10 ):841-8
26407494
N Engl J Med. 2008 Jan 3;358(1):55-68
18172175
Br J Psychiatry. 2002 Nov;181:411-5
12411267
Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10046-51
16788060
Neurobiol Dis. 2013 Apr;52:24-37
22426398
Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):11020-5
20534464
Psychol Med. 2012 Apr;42(4):671-81
21910935
World J Biol Psychiatry. 2010 Feb;11(1):19-35
19347777