Contribution of Post-translational Phosphorylation to Sarcomere-Linked Cardiomyopathy Phenotypes.
Secondary shifts develop in post-translational phosphorylation of sarcomeric proteins in multiple animal models of inherited cardiomyopathy. These signaling alterations together with the primary mutation are predicted to contribute to the overall cardiac phenotype. As a result, identification and integration of post-translational myofilament signaling responses are identified as priorities for gaining insights into sarcomeric cardiomyopathies. However, significant questions remain about the nature and contribution of post-translational phosphorylation to structural remodeling and cardiac dysfunction in animal models and human patients. This perspective essay discusses specific goals for filling critical gaps about post-translational signaling in response to these inherited mutations, especially within sarcomeric proteins. The discussion focuses primarily on pre-clinical analysis of animal models and defines challenges and future directions in this field.
Department of Cardiac Surgery, University of Michigan Ann Arbor, MI, USA.
Margaret V
MV
Westfall
cardiomyopathy; myofilament; phosphorylation; post-translational modification; signaling
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