Whole-body MRI in patients with Non-bacterial Osteitis: Radiological findings and correlation with clinical data.
OBJECTIVE
To correlate clinical findings of Non-bacterial Osteitis (NBO) with whole-body MRI (WB-MRI) findings and determine a radiologic index for NBO (RINBO) which allows standardized reporting of WB-MRI.


METHODS
In a prospective study, 40 patients with diagnosis of NBO underwent clinical examination and WB-MRI in which STIR- and T1- weighted images were assessed for NBO-typical lesions. Parameters of interest for RINBO were: number of radiologically active lesions (RAL), size of the patients' maximum RAL presence of extramedullary and spinal involvement. Results were tested for statistical agreement of clinical and MR-based lesion detection. RINBO was tested for correlation with clinical activity.


RESULTS
62/95 clinically/radiologically active lesions were found in 30/33 patients. In 45 % of the cohort, more active lesions were detected by WB-MRI than by clinical examination. RINBO was a significant predictor for the presence of clinically active lesions.


CONCLUSIONS
WB-MRI is a powerful diagnostic tool for patients with NBO which can reveal asymptomatic disease activity. With RINBO a standardized evaluation approach is proposed which helps assessing radiologic disease burden and predicts clinical disease activity.


CONCLUSIONS
• Whole body MRI is a powerful diagnostic tool for patients with non-bacterial Osteitis. • Whole body MRI can reveal asymptomatic disease activity. • The radiologic index RINBO offers a standardized evaluation approach.
Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital, Nussbaumstrasse 20, 80336, Munich, Germany. Andreas.Arnoldi@med.uni-muenchen.de.
A P
AP
Arnoldi
Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany.
C L
CL
Schlett
Department of Radiology, University Hospital Birmingham, Birmingham, B15 2TH, United Kingdom.
H
H
Douis
Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital, Nussbaumstrasse 20, 80336, Munich, Germany.
L L
LL
Geyer
Department of Rheumatology & Immunology, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University, Munich, Germany.
A M
AM
Voit
Department of Rheumatology & Immunology, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University, Munich, Germany.
F
F
Bleisteiner
Department of Rheumatology & Immunology, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University, Munich, Germany.
A F
AF
Jansson
Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany.
S
S
Weckbach
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D010000:Osteitis / Q000473:pathology*; D010808:Physical Examination / Q000379:methods; D011446:Prospective Studies; D051598:Whole Body Imaging / Q000379:methods; D055815:Young Adult
D015415:Biomarkers
Activity score; CRMO; Magnetic resonance imaging; Non-bacterial Osteitis; Whole body imaging
Rofo. 2013 Jul;185(7):655-61
23696017
Ann Rheum Dis. 2005 Feb;64(2):279-85
15647436
Radiology. 2011 Jul;260(1):174-81
21518775
Radiology. 2013 Dec;269(3):730-7
24023074
Int J Rheumatol. 2012;2012:310206
22685464
Arthritis Rheum. 2009 Apr;60(4):1152-9
19333943
Pediatr Rheumatol Online J. 2012 Jul 31;10(1):20
22849717
Eur J Pediatr. 2010 Sep;169(9):1105-11
20339868
Radiology. 2009 Sep;252(3):842-51
19567645
Skeletal Radiol. 1997 Apr;26(4):230-8
9151372
Pediatr Radiol. 2006 Sep;36 Suppl 2:110-2
16862422
Pediatr Radiol. 2009 Nov;39(11):1142-6
19789861
Eur Spine J. 1998;7(4):340-3
9765044
Pediatr Radiol. 2013 Mar;43(3):355-75
23263195
Eur J Radiol. 2011 Jan;77(1):149-55
19632076
Eur J Radiol. 2009 Jun;70(3):431-41
19394781
Semin Musculoskelet Radiol. 2004 Sep;8(3):243-53
15478027
Spinal Cord. 1999 Apr;37(4):301-4
10338354
Eur Radiol. 2002 Feb;12(2):416-26
11870444
Case Rep Pediatr. 2013;2013:649097
23997974
Ann Radiol (Paris). 1972 Mar-Apr;15(3):329-42
4403064
J Rheumatol. 2015 Aug;42(8):1455-62
25979713
Semin Musculoskelet Radiol. 2009 Jun;13(2):120-33
19455475
J Rheumatol. 2015 Aug;42(8):1359-60
26233948
Rheumatology (Oxford). 2014 Nov;53(11):1973-6
24899664
Joint Bone Spine. 2011 Dec;78(6):555-60
21441060
Eur J Hum Genet. 2002 Mar;10(3):217-21
11973628
Semin Musculoskelet Radiol. 2012 Nov;16(5):377-88
23212873
J Bone Joint Surg Br. 1980 Aug;62(3):376-80
7410472
Hum Pathol. 1999 Jan;30(1):59-65
9923928
Rheumatology (Oxford). 2007 Jan;46(1):154-60
16782988
Acta Paediatr. 2011 Aug;100(8):1150-7
21352353
Eur J Radiol. 2009 Jun;70(3):393-400
19457631