Altered functional connectivity of the marginal division in migraine: a resting-state fMRI study.
BACKGROUND
The marginal division of neostriatum (MrD) is a flat, pan-shaped zone between the neostriatum and the globus pallidus, and previous documents demonstrated that it was involved in the modulation of pain. The aim of this study is to investigate the roles of the MrD of the human brain in the chronicization migraine using resting state functional magnetic resonance imaging (rs-fMRI).


METHODS
Conventional MRI, 3D structure images, and rs-fMRI were performed in 18 patients with episodic migraines (EM), 16 patients with chronic migraine (CM), 44 patients with medication overuse headache plus chronic migraine (MOH + CM), and 32 normal controls (NC). MrD was defined using manual delineation on structural images, and was selected as the seed to calculate the functional connectivity (FC).


RESULTS
Compared with the NC group, the decreased FC of MrD was observed in the EM and CM groups, and increased FC of MrD was demonstrated in all patient groups. Compared with the EM group, the decreased FC of MrD was revealed in the CM and MOH + CM groups, and the increased FC occurred only in the CM group. Increased FC of MrD alone was observed in the MOH + CM group compared with that in the CM group.


CONCLUSIONS
This study confirmed the double neuromodulation network of MrD in pain modulation and migraine chronicization; however, the mechanism requires further investigation.
Department of Radiology, Chinese PLA General Hospital, Beijing, 100853, China.|Department of Neurology, Chinese PLA General Hospital, Beijing, 100853, China.
Zhiye
Z
Chen
Department of Neurology, Chinese PLA General Hospital, Beijing, 100853, China.
Xiaoyan
X
Chen
Department of Radiology, Chinese PLA General Hospital, Beijing, 100853, China.
Mengqi
M
Liu
Department of Radiology, Chinese PLA General Hospital, Beijing, 100853, China.
Shuangfeng
S
Liu
Institute of Cognitive Neuroscience, South China Normal University, Guangzhou, 510631, China.
Siyun
S
Shu
Department of Radiology, Chinese PLA General Hospital, Beijing, 100853, China.
Lin
L
Ma
Department of Neurology, Chinese PLA General Hospital, Beijing, 100853, China. yusy1963@126.com.
Shengyuan
S
Yu
D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D059350:Chronic Pain / Q000503:physiopathology*; D005260:Female; D051271:Headache Disorders, Secondary / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000503:physiopathology*; D017072:Neostriatum / Q000503:physiopathology*; D009415:Nerve Net / Q000503:physiopathology*
Functional connectivity; Marginal division of the neostriatum; Migraine; fMRI
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