Rerandomization to Balance Tiers of Covariates.
When conducting a randomized experiment, if an allocation yields treatment groups that differ meaningfully with respect to relevant covariates, groups should be rerandomized. The process involves specifying an explicit criterion for whether an allocation is acceptable, based on a measure of covariate balance, and rerandomizing units until an acceptable allocation is obtained. Here we illustrate how rerandomization could have improved the design of an already conducted randomized experiment on vocabulary and mathematics training programs, then provide a rerandomization procedure for covariates that vary in importance, and finally offer other extensions for rerandomization, including methods addressing computational efficiency. When covariates vary in a priori importance, better balance should be required for more important covariates. Rerandomization based on Mahalanobis distance preserves the joint distribution of covariates, but balances all covariates equally. Here we propose rerandomizing based on Mahalanobis distance within tiers of covariate importance. Because balancing covariates in one tier will in general also partially balance covariates in other tiers, for each subsequent tier we explicitly balance only the components orthogonal to covariates in more important tiers.
Department of Statistics, Penn State University, University Park, PA 16802 ( klm47@psu.edu ).
Kari Lock
KL
Morgan
Department of Statistics, Harvard University, Cambridge, MA 02138.
Donald B
DB
Rubin
Mahalanobis distance; causal inference; covariate balance; experimental design; randomization; treatment allocation
Clin Trials. 2004;1(3):297-305
16279255
Basic Clin Pharmacol Toxicol. 2006 Mar;98(3):243-52
16611198