Integrated analysis of ischemic stroke datasets revealed sex and age difference in anti-stroke targets.
Ischemic stroke is a common neurological disorder and the burden in the world is growing. This study aims to explore the effect of sex and age difference on ischemic stroke using integrated microarray datasets. The results showed a dramatic difference in whole gene expression profiles and influenced pathways between males and females, and also in the old and young individuals. Furthermore, compared with old males, old female patients showed more serious biological function damage. However, females showed less affected pathways than males in young subjects. Functional interaction networks showed these differential expression genes were mostly related to immune and inflammation-related functions. In addition, we found ARG1 and MMP9 were up-regulated in total and all subgroups. Importantly, IL1A, ILAB, IL6 and TNF and other anti-stroke target genes were up-regulated in males. However, these anti-stroke target genes showed low expression in females. This study found huge sex and age differences in ischemic stroke especially the opposite expression of anti-stroke target genes. Future studies are needed to uncover these pathological mechanisms, and to take appropriate pre-prevention, treatment and rehabilitation measures.
Institute of Health Sciences, Anhui University, Hefei, Anhui, China.|State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
Wen-Xing
WX
Li
State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.|Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China.
Shao-Xing
SX
Dai
State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.|Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China.
Qian
Q
Wang
State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
Yi-Cheng
YC
Guo
Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University, Hefei, Anhui, China.
Yi
Y
Hong
State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.|Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China.
Jun-Juan
JJ
Zheng
State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.|Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China.
Jia-Qian
JQ
Liu
Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University, Hefei, Anhui, China.
Dahai
D
Liu
State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.|Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China.
Gong-Hua
GH
Li
State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.|Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China.|KIZ-SU Joint Laboratory of Animal Models and Drug Development, College of Pharmaceutical Sciences, Soochow University, Kunming, Yunnan, China.|Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan, Kunming, Yunnan, China.
Jing-Fei
JF
Huang
Anti-stroke target; Ischemic stroke; Sex and age difference
Neuroscience. 2015 Oct 29;307:160-70
26327363
Chem Biol. 2009 Jul 31;16(7):783-94
19635415
J Cereb Blood Flow Metab. 2012 May;32(5):780-91
22167233
Neuroreport. 2013 Jan 9;24(1):36-40
23168565
FASEB J. 1990 Aug;4(11):2860-7
2199284
Int J Stroke. 2010 Jun;5(3):152-6
20536610
Stroke. 2010 Mar;41(3):e123-8
20035078
Nucleic Acids Res. 2013 Jul;41(Web Server issue):W115-22
23794635
J Stroke Cerebrovasc Dis. 2013 Oct;22(7):1070-5
22939200
Stroke. 2013 Jul;44(7):2064-89
23652265
Mol Med Rep. 2015 Jan;11(1):29-36
25333814
Adv Immunol. 1988;42:213-31
2834923
J Neurosci. 2001 Oct 1;21(19):7724-32
11567062
Lancet Neurol. 2008 Oct;7(10):915-26
18722812
J Stroke Cerebrovasc Dis. 2015 Nov;24(11):2613-8
26341732
Neurochem Int. 2015 Nov;90:1-8
26116440
Stroke. 2011 Dec;42(12):3651-4
22052510
J Neurochem. 2014 May;129(4):683-95
24447140
Stroke. 1999 Oct;30(10):2174-9
10512924
Science. 1985 Nov 8;230(4726):630-2
2413547
Neurology. 2010 Sep 14;75(11):1009-14
20837969
Neurosci Bull. 2015 Aug;31(4):480-90
26254060
Nat Immunol. 2008 Dec;9(12):1399-406
18978793
PLoS One. 2014 Jul 18;9(7):e102550
25036109
Stroke. 2009 Apr;40(4):1082-90
19211488
Eur J Pharmacol. 2011 Jul 1;661(1-3):49-56
21545800
Respirol Case Rep. 2015 Nov 30;4(1):4-6
26839691
Neuroepidemiology. 2015 ;45(3):203-14
26505984
Lancet. 2014 Jan 18;383(9913):245-54
24449944
Eur J Pharmacol. 2007 Mar 8;558(1-3):88-95
17239368
Circulation. 1999 Mar 2;99(8):1091-100
10051305
Nucleic Acids Res. 2015 Apr 20;43(7):e47
25605792
J Neurochem. 2009 Nov;111(3):808-18
19712053
Stroke. 2015 Dec;46(12):3564-70
26486867
J Cereb Blood Flow Metab. 2015 Oct;35(10 ):1657-63
25966956
J Biol Chem. 2007 Jan 12;282(2):1238-48
17085445
Nat Rev Drug Discov. 2012 Aug;11(8):633-52
22850787
Curr Opin Pharmacol. 2016 Feb;26:80-6
26562440
J Pharmacol Exp Ther. 2009 Feb;328(2):435-47
18984655
Circulation. 2000 Apr 18;101(15):1767-72
10769275
J Cereb Blood Flow Metab. 1999 Sep;19(9):1004-9
10478652
J Cereb Blood Flow Metab. 2012 Jun;32(6):1061-72
22453632
Nat Protoc. 2009;4(1):44-57
19131956
CMAJ. 2015 Sep 8;187(12):887-93
26243819
Bioinformatics. 2010 Oct 1;26(19):2363-7
20688976
Int Immunopharmacol. 2006 Mar;6(3):426-32
16428078
Lancet. 2016 Mar 26;387(10025):1305-11
26880122
J Alzheimers Dis. 2016;51(2):417-25
26890750