Primary malignant melanoma of cervix and vagina.
Primary malignant melanoma (MM) accounts for 1% of all cancers, and only 3% to 7% of these tumors occur in the female genital tract. Data are limited with respect to the basis for treatment recommendations because of the rarity of MM. The overall prognosis of melanomas of the female genital tract is very poor. Two cases of MM of the female genital tract are presented. The first case is of a 70-year-old female patient who complained of left thigh pain and underwent magnetic resonance imaging that showed cervical cancer with involvement of the vagina, bladder, and parametrium, in addition to multiple bony metastases of the proximal femur, acetabulum, and both iliac bones. The second case is of a 35-year-old female patient who suffered from vaginal bleeding for 5 months, and she was diagnosed as having primary vaginal melanoma. The patient underwent radical surgery and two additional surgeries because of recurrence of cancer in both inguinal areas. After surgery, the patient received adjuvant immunotherapy, radiation therapy, and chemotherapy. In both the aforementioned cases, the pathologic diagnosis was made after immunohistochemical analysis, i.e., the tumor cells were stained with HMB-45 and S100, and were found to be positive for both immunostains.
Department of Obstetrics and Gynecology, Institute of Women's Medical Life Science, Yonsei University College of Medicine, Seoul, Korea.
Jae Hoon
JH
Lee
Department of Obstetrics and Gynecology, Institute of Women's Medical Life Science, Yonsei University College of Medicine, Seoul, Korea.
Jisun
J
Yun
Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Jung-Won
JW
Seo
Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Go-Eun
GE
Bae
Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Jeong-Won
JW
Lee
Department of Obstetrics and Gynecology, Institute of Women's Medical Life Science, Yonsei University College of Medicine, Seoul, Korea.
Sang Wun
0000-0002-8342-8701
SW
Kim
Cervix uteri; Primary malignant melanoma; Vagina
Prim Care Update Ob Gyns. 1998 Jul 1;5(4):159-160
10838297
Obstet Gynecol. 2010 Dec;116(6):1358-65
21099603
Ann Surg Oncol. 2015;22(6):1959-66
25384702
Int J Gynecol Pathol. 1999 Jul;18(3):265-73
12090596
Ecancermedicalscience. 2015 Sep 10;9:571
26435744
Gynecol Oncol. 1989 Mar;32(3):375-80
2646184
Gynecol Oncol. 2013 Jun;129(3):533-7
23480869
Gynecol Oncol. 2008 Mar;108(3):478-81
18190952
Int J Gynecol Pathol. 2008 Oct;27(4):596-600
18753958
Gynecol Obstet Invest. 1991;31(2):121-4
2037261
Int J Gynecol Pathol. 2016 Sep;35(5):419-22
26630224
Am J Obstet Gynecol. 1998 Jun;178(6):1177-84
9662299
Cancer. 1998 Oct 15;83(8):1664-78
9781962
Int J Gynecol Cancer. 2014 Jan;24(1):149-55
24362720
Obstet Gynecol Surv. 1976 Apr;31(4):233-71
1256721