Salivary interleukin-1β: Oral inflammatory biomarker in patients with psoriasis.
OBJECTIVE
To evaluate salivary interleukin (IL)-1β levels in patients with psoriasis, before and after treatment with tumour necrosis factor (TNF)-α inhibitors.


METHODS
In this pilot study, salivary secretions were collected from patients with psoriasis and untreated healthy control subjects at baseline, and from patients after 12 weeks' treatment with TNF-α inhibitors. IL-1β levels were determined in saliva samples via enzyme-linked immunosorbent assays, undertaken before and after TNF-α inhibitor treatment. Psoriasis-specific analysis of disease severity and activity were also undertaken.


RESULTS
At baseline, patients (n = 25) had significantly higher salivary IL1β levels than controls (n = 20). In patients with psoriasis, TNF-α inhibitor treatment resulted in significantly reduced IL1β levels compared with baseline, but IL1β levels remained significantly higher than in control subjects even after treatment. There was a positive correlation between IL-1β levels, psoriasis activity and disease index score after TNF-α inhibitor treatment.


CONCLUSIONS
Saliva is a valid noninvasive tool for monitoring inflammation in psoriasis. TNF-α inhibitor treatments appear to interfere with the oral inflammatory process in patients with psoriasis.
Dermatology Clinic, Polytechnic University of Marche Region, Ancona, Italy.
Giulia
G
Ganzetti
Dermatology Clinic, Polytechnic University of Marche Region, Ancona, Italy anna.campanati@gmail.com.
Anna
A
Campanati
Department of Clinical Specialist and Stomatological Sciences, Polytechnic University of Marche Region, Ancona, Italy.
Andrea
A
Santarelli
Department of Clinical Specialist and Stomatological Sciences, Polytechnic University of Marche Region, Ancona, Italy.
Davide
D
Sartini
Dermatology Clinic, Polytechnic University of Marche Region, Ancona, Italy.
Elisa
E
Molinelli
Dermatology Clinic, Polytechnic University of Marche Region, Ancona, Italy.
Valerio
V
Brisigotti
Department of Clinical Specialist and Stomatological Sciences, Polytechnic University of Marche Region, Ancona, Italy.
Giulia
G
Di Ruscio
Dermatology Clinic, Polytechnic University of Marche Region, Ancona, Italy.
Ivan
I
Bobyr
Department of Clinical Specialist and Stomatological Sciences, Polytechnic University of Marche Region, Ancona, Italy.
Monica
M
Emanuelli
Dermatology Clinic, Polytechnic University of Marche Region, Ancona, Italy.
Annamaria
A
Offidani
IL-1β; TNF-α inhibitor treatment; oral biomarker; psoriasis
Acta Odontol Scand. 2010 May;68(3):165-70
20141361
JAMA. 1997 Mar 19;277(11):925-6
9062334
Drug Dev Res. 2014 Nov;75 Suppl 1:S46-9
25381976
Br J Dermatol. 2014 Feb;170(2):274-303
24131260
J Periodontol. 2014 Nov;85(11):1480-8
24857321
Dent Clin North Am. 2011 Jan;55(1):159-78
21094724
Dermatology. 2008;217(1):27-37
18349542
Am J Clin Dermatol. 2010;11 Suppl 1:46-8
20586509
Exp Dermatol. 2007 Oct;16(10):779-98
17845210
Biomed Res. 2013 Feb;34(1):31-40
23428978
J Gastroenterol. 2013 Jul;48(7):839-46
23065020
Dermatology. 2008;216(2):152-5
18216477
J Am Acad Dermatol. 2004 Oct;51(4):563-9
15389191
Br J Dermatol. 2015 Jan;172(1):282-5
25078556
Clin Dermatol. 2007 Nov-Dec;25(6):535-46
18021890
ScientificWorldJournal. 2010 Mar 16;10:434-56
20305986
J Dermatolog Treat. 2008;19(1):5-21
18273720
Br J Dermatol. 2011 Sep;165(3):585-92
21623755
J Invest Dermatol. 2012 Sep;132(9):2206-14
22513786