Unresectability during open surgical exploration in planned cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy are the treatment of choice for selected patients with peritoneal metastasis. Despite a stringent selection process, some patients were found to be unresectable only at surgery, which leads to disappointment and poor utilisation of limited infrastructural resources. This study aims to determine the pre-operative factors associated with unresectability in planned CRS and HIPEC.



Retrospective analysis of 172 consecutive patients eligible for CRS and HIPEC at the National Cancer Centre Singapore from April 2004 to May 2014 was performed. Pre-operative factors (clinical presentation, disease factors, and investigation findings) between the unresectable (13%) and the successful groups (87%) were compared.



Patient demographics between the two cohorts were comparable. In terms of clinical presentation, the unresectable group was more likely to present with bloating (p = .00), altered bowel habits (p = .04), abdominal distension (p = .00), palpable abdominal masses (p = .00) and palpable pouch of Douglas nodules (p = .00). Differences were also noted in disease factors with the unresectable group having more high-grade tumours (p = .01), inadequate initial resections (p = .01), progression through chemotherapy (p = .00) and shorter median disease-free intervals (p = .03). In addition, investigations in the unresectable group revealed more patients with elevated tumour markers (p = .01), thrombocytosis (p = .00) and computed tomography findings of ascites (p = .00), omental thickening (p = .00), lymphadenopathy (p = .02) and small bowel disease (p = .00).



Significant factors associated with unresectability that were identified in our study could potentially create a new treatment algorithm and refine current selection process to exclude patients at risk of unresectability in planned CRS and HIPEC.
a Department of General Surgery , Singapore General Hospital , Singapore, Singapore.
Zachary Zihui
ZZ
Yong
b Division of Surgical Oncology , National Cancer Centre Singapore , Singapore, Singapore.
Grace Hwei Ching
GH
Tan
a Department of General Surgery , Singapore General Hospital , Singapore, Singapore.
Joelle Fui Sze
JF
Wong
c Department of Clinical Trials and Epidemiological Science , National Cancer Centre Singapore , Singapore, Singapore.
Cindy
C
Lim
b Division of Surgical Oncology , National Cancer Centre Singapore , Singapore, Singapore.
Khee Chee
KC
Soo
b Division of Surgical Oncology , National Cancer Centre Singapore , Singapore, Singapore.
Melissa Ching Ching
MC
Teo
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003131:Combined Modality Therapy; D065426:Cytoreduction Surgical Procedures; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000601:surgery* / Q000628:therapy*; D055815:Young Adult
Peritoneal metastasis; cytoreductive surgery and hyperthermic intraperitoneal chemotherapy; pre-operative factors; successful surgery; unresectability