Clinical significance and prognostic value of TRIM24 expression in esophageal squamous cell carcinoma.
Tripartite motif-containing 24 (TRIM24), a member of the transcription intermediary factor 1 family, is defined as a co-regulator with several nuclear receptors, such as RARα. TRIM24 has been reported to be involved in many cancers. In this study, we aimed to investigate the expression pattern and prognostic significance of TRIM24 and its relationship with RARα in esophageal squamous cell cancer (ESCC). Both mRNA and protein expression levels of TRIM24 were found to be significantly decreased in ESCC, as judged by qRT-PCR and western blot. Immunohistochemistry staining shows that the reduced TRIM24 protein is associated with lymph node metastasis (P=0.024), advance pathological TNM (pTNM) stage (P=0.046) and recurrence/metastasis (P=0.001). Upregulated TRIM24 protein predicts longer overall survival and disease-free survival (bothP<0.001) and is an independent predictor for good prognosis (HR, 0.519; 95%CI, 0.341-0.788;P=0.002). TRIM24 expression has been proven remarkably to improve prediction of survival of pTNM stage in ESCC patients, especially in stage I and II. However, no significant relationship was found between TRIM24 and RARα expression levels. In conclusion, reduced TRIM24 protein is associated with poor survival in ESCC patients, suggesting TRIM24 protein is a potential prognostic biomarker for ESCC.
Department of Endoscopy and Laser, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.|State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.|Guangdong Esophageal Cancer Institute, Guangzhou 510060, China.|Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
Jun
J
Chi
Department of Endoscopy and Laser, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.|State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.|Guangdong Esophageal Cancer Institute, Guangzhou 510060, China.|Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
Qing
Q
Yang
Department of Endoscopy and Laser, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.|State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.|Guangdong Esophageal Cancer Institute, Guangzhou 510060, China.|Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
Xiao-Feng
XF
Xie
State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.|Guangdong Esophageal Cancer Institute, Guangzhou 510060, China.|Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
Xian-Zi
XZ
Yang
State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.|Guangdong Esophageal Cancer Institute, Guangzhou 510060, China.|Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
Mei-Yin
MY
Zhang
State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.|Guangdong Esophageal Cancer Institute, Guangzhou 510060, China.|Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
Hui-Yun
HY
Wang
Department of Endoscopy and Laser, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.|State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.|Guangdong Esophageal Cancer Institute, Guangzhou 510060, China.|Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
Guo-Liang
GL
Xu
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism*; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D004938:Esophageal Neoplasms / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D000072482:Retinoic Acid Receptor alpha / Q000235:genetics / Q000378:metabolism; D016019:Survival Analysis
D002352:Carrier Proteins; D012333:RNA, Messenger; D000072482:Retinoic Acid Receptor alpha; C555317:TRIM24 protein, human
RARα; TRIM24; esophageal squamous cell cancer; prognosis
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