[Physical activity as therapeutic intervention for depression].
OBJECTIVE
This article gives a conspectus of the present state of research on the efficiency of exercise as a treatment for patients suffering from depression.


METHODS
A systematic review of articles published between December 1980 and March 2016 was carried out. The review focused on studies that examined the effects of exercise compared to control conditions in the treatment of depression. Extracted and analyzed information from the articles included details about participants, characteristics of exercise and control conditions, assessments, study design and outcomes.


RESULTS
A total of 34 of the 48 studies included in the literature search reported a significant reduction of depressive symptoms due to exercise interventions. There was a trend to reduced depressive symptoms following the exercise interventions in five studies. In nine studies no positive impact of exercise on depression and affective well-being could be detected.


CONCLUSIONS
This review article shows that physical activity decreases depressive symptoms and increases affective well-being in patients with depressive diseases; therefore, exercise should be recommended as a component of depression treatment within the framework of a multi-dimensional approach.
Institut für Sportwissenschaft, Universität Innsbruck, Fürstenweg 185, 6020, Innsbruck, Österreich. Larissa.ledochowski@uibk.ac.at.
L
L
Ledochowski
Kepler Universitätsklinikum, Neuromed Campus, Wagner-Jauregg-Weg 15, 4020, Linz, Österreich.
R
R
Stark
Institut für Sportwissenschaft, Universität Innsbruck, Fürstenweg 185, 6020, Innsbruck, Österreich.
G
G
Ruedl
Institut für Sportwissenschaft, Universität Innsbruck, Fürstenweg 185, 6020, Innsbruck, Österreich.
M
M
Kopp
D018849:Controlled Clinical Trials as Topic; D003866:Depressive Disorder / Q000175:diagnosis / Q000523:psychology / Q000628:therapy*; D005069:Evaluation Studies as Topic; D015444:Exercise / Q000523:psychology*; D006801:Humans; D010043:Outcome and Process Assessment, Health Care
Affective well-being; Depression; Evaluation studies; Exercise; Physical activity
Cochrane Database Syst Rev. 2009 Jul 08;(3):CD007954
19588448
Br J Sports Med. 2007 Jan;41(1):29-33
17062659
Br J Soc Clin Psychol. 1967 Dec;6(4):278-96
6080235
Drug Healthc Patient Saf. 2012;4:93-101
22936860
Br J Psychiatry. 2015 Sep;207(3):227-34
26089305
Eur J Public Health. 2006 Apr;16(2):179-84
16126743
Am J Geriatr Psychiatry. 2011 Oct;19(10):839-50
21358389
J Affect Disord. 2015 May 15;177:1-6
25743367
Brain Cogn. 2004 Aug;55(3):516-24
15223198
Aging Ment Health. 2008 Jan;12(1):72-80
18297481
Am J Prev Med. 2005 Jan;28(1):1-8
15626549
Int J Nurs Stud. 2015 Oct;52(10):1542-52
26105535
Psychol Aging. 1991 Sep;6(3):487-8
1930766
Percept Mot Skills. 2011 Jun;112(3):761-9
21853765
J Consult Clin Psychol. 1989 Feb;57(1):158-61
2925967
J Gerontol A Biol Sci Med Sci. 2005 Jun;60(6):768-76
15983181
World Psychiatry. 2002 Feb;1(1):10-5
16946806
J Pers Soc Psychol. 1984 May;46(5):1142-7
6737208
Arch Phys Med Rehabil. 2012 Aug;93(8):1319-23
22840829
Br J Sports Med. 2009 Oct;43(10):756-9
19019899
Depress Res Treat. 2013;2013:132684
24349769
Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5638-43
17374720
Ann Clin Psychiatry. 2002 Sep;14(3):143-7
12585563
Br J Psychiatry. 2002 May;180:411-5
11983637
Res Q Exerc Sport. 1995 Dec;66(4):268-75
8775581
Complement Ther Med. 2014 Aug;22(4):614-20
25146063
Clin Trials. 2006;3(3):291-305
16895046
Ann Fam Med. 2010 May-Jun;8(3):214-23
20458104
J Psychiatr Res. 2011 Aug;45(8):1005-11
21377690
Ment Health Phys Act. 2016 Mar;10 :68-72
27453730
Cochrane Database Syst Rev. 2013 Sep 12;(9):CD004366
24026850
Aging Ment Health. 2007 Jan;11(1):61-8
17164159
Br Med J (Clin Res Ed). 1985 Jul 13;291(6488):109
3926074
J Clin Psychiatry. 2012 Sep;73(9):1234-42
23059149
Control Clin Trials. 2002 Oct;23(5):584-603
12392873
Int J Geriatr Psychiatry. 2011 Mar;26(3):322-7
20848578
Psychiatry Res. 2006 Nov 29;145(1):79-83
17081621
J Consult Clin Psychol. 1987 Oct;55(5):748-54
3454786
Conscious Cogn. 2003 Jun;12(2):231-56
12763007
PM R. 2010 Oct;2(10):911-9
20970760
J Gerontol A Biol Sci Med Sci. 1997 Jan;52(1):M27-35
9008666
Arch Gen Psychiatry. 1961 Jun;4:561-71
13688369
Cochrane Database Syst Rev. 2012 Jul 11;(7):CD004366
22786489
Prog Neurobiol. 2000 Jul;61(4):397-414
10727781
Clin Pract Epidemiol Ment Health. 2007 Jul 09;3:8
17620123
Trends Neurosci. 2000 Oct;23(10):475-83
11006464
Psychosom Med. 2007 Sep-Oct;69(7):587-96
17846259
Med Sci Sports Exerc. 1997 Jan;29(1):58-62
9000156
Int J Geriatr Psychiatry. 2006 Sep;21(9):890-7
16955451
Prim Care Companion J Clin Psychiatry. 2004;6(3):104-111
15361924
Syst Rev. 2015 Apr 02;4:40
25875610
Arch Intern Med. 1999 Oct 25;159(19):2349-56
10547175
Psychiatry Res. 2000 Apr 24;94(1):29-42
10788675
Neuropsychiatr. 2009;23(3):151-6
19703380
BMC Public Health. 2011 Jun 12;11:465
21663696
Health Psychol. 2002 Nov;21(6):553-63
12433007
Innov Clin Neurosci. 2012 May;9(5-6):41-6
22808448
Mol Psychiatry. 2016 Jun;21(6):806-12
26122586
Hum Psychopharmacol. 2011 Mar;26(2):161-7
21462268
Eur J Appl Physiol Occup Physiol. 1991;63(2):83-8
1748109
Exp Brain Res. 2000 Jul;133(1):3-11
10933205
J Affect Disord. 2011 Oct;133(3):615-8
21616540
J Psychosom Res. 2010 Aug;69(2):119-31
20624510
Br J Sports Med. 2014 Feb;48(3):226-32
23833045
BMC Psychiatry. 2012 Oct 30;12:182
23110608
J Womens Health (Larchmt). 2007 Dec;16(10):1499-509
18062765
Psychosom Med. 2000 Sep-Oct;62(5):633-8
11020092
Top Stroke Rehabil. 2009 Mar-Apr;16(2):157-66
19581202
Psychosom Med. 2011 Feb-Mar;73(2):127-33
21148807
Trials. 2010 Nov 12;11:105
21073712
BMJ. 2012 Jun 06;344:e2758
22674921
Psychol Med. 2014 Jan;44(2):303-14
23574735
Eur Arch Psychiatry Clin Neurosci. 2012 Nov;262 Suppl 2:S117-21
22955493
JAMA. 2012 Aug 1;308(5):465-74
22851113
J Clin Psychiatry. 2009 Jun;70(6):790-800
19573478
J Affect Disord. 2014 Oct;168:98-106
25043321
Int J Geriatr Psychiatry. 2009 Jan;24(1):76-83
18613281
J R Soc Med. 1992 Sep;85(9):541-4
1433121
Br J Psychiatry. 2015 Sep;207(3):235-42
26206864
PLoS One. 2012;7(10):e48316
23118981
Rehabil Res Pract. 2014;2014:627376
24800081
Clin Pract Epidemiol Ment Health. 2008 Jan 26;4:1
18221549
Behav Ther. 2016 Jul;47(4):527-37
27423168
Br J Psychiatry. 2012 Sep;201(3):180-5
22945926
J Sport Exerc Psychol. 2007 Jun;29(3):348-64
17876971