[Causative Genes for Amyotrophic Lateral Sclerosis].
About 20 causative genes were reported for amyotrophic lateral sclerosis. Using next generation sequencer, new genes have been sequentially reported. These genes' products are thought to be involved in the pathologic mechanism of ALS. The pathophysiology is investigated and disease characteristics are discussed according to the causative genes. In addition, genetic counseling is recommended when genetic diagnosis is attempted.
Department of Clinical Neuroscience & Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences.
Hirofumi
H
Maruyama
Hiroyuki
H
Morino
Hideshi
H
Kawakami
D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis / Q000235:genetics*; D005817:Genetic Counseling; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D010641:Phenotype