Prostate Cancer Genetics: A Review.
Over the past decades, research has focussed on identifying the genetic underpinnings of prostate cancer. It has been recognized that a number of forms of genetic changes coupled with epigenetic and gene expression changes can increase the prediction to develop prostate cancer. This review outlines the role of somatic copy number alterations (SCNAs), structural rearrangements, point mutations, and single nucleotide polymorphisms (SNPs) as well as miRNAs. Identifying relevant genetic changes offers the ability to develop novel biomarkers to allow early and accurate detection of prostate cancer as well as provide risk stratification of patients following their diagnosis. The concept of personalized or individualized medicine has gained significant attention. Therefore, a better understanding of the genetic and metabolic pathways underlying prostate cancer development offers the opportunity to explore new therapeutic interventions with the possibility of offering patient-specific targeted therapy.
Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto , Toronto, Ontario, Canada.
Christopher J D
CJ
Wallis
Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto , Toronto, Ontario, Canada.
Robert K
RK
Nam
DNA copy number variations; chromosome abnormalities; genetic predisposition; microRNAs; point mutation; polymorphism; prostate cancer; single nucleotide
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