Assessment of severity and changes in C-reactive protein concentration and various biomarkers in dogs with pancreatitis.
Canine pancreatitis is a relatively common disorder, and its mortality rate remains high. However, prognostic factors for pancreatitis based on evidence are limited. Moreover, the relationship between changes in C-reactive protein (CRP) concentration-an important prognostic factor for human patients with acute pancreatitis-and the prognosis of dogs with pancreatitis has not been widely studied. Therefore, we examined prognostic factors for canine pancreatitis during the first medical examination and evaluated the usefulness of serial CRP measurements during hospitalization. Sixty-five dogs met the inclusion criteria, including 22 that were hospitalized and treated. In Study 1, a multivariate analysis revealed that three factors- decreased platelet count and a marked (greater than 1,000 µg/l) elevation of specific canine pancreatic lipase (Spec cPL) concentration at the first medical examination, as well as elevated blood urea nitrogen (BUN) and/or creatinine (CRE) level-were significantly different between the survivors and nonsurvivors. Moreover, CRP concentrations on the third and fourth days were significantly different between the two groups in Study 2. An evaluation of the decreased platelet count, remarkable elevation of Spec cPL concentration at the first medical examination, elevation of BUN and/or CRE as well as serial CRP concentration measurements may be useful for predicting the prognosis of canine pancreatitis.
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
Toru
T
Sato
Koichi
K
Ohno
Takashi
T
Tamamoto
Mariko
M
Oishi
Hideyuki
H
Kanemoto
Kenjiro
K
Fukushima
Yuko
Y
Goto-Koshino
Masashi
M
Takahashi
Hajime
H
Tsujimoto
D000818:Animals; D015415:Biomarkers / Q000097:blood; D001806:Blood Urea Nitrogen; D002097:C-Reactive Protein / Q000032:analysis*; D003404:Creatinine / Q000097:blood; D004283:Dog Diseases / Q000097:blood / Q000175:diagnosis*; D004285:Dogs; D005260:Female; D008049:Lipase / Q000097:blood; D008297:Male; D010195:Pancreatitis / Q000097:blood / Q000662:veterinary*; D010976:Platelet Count / Q000662:veterinary; D011379:Prognosis; D012720:Severity of Illness Index
D015415:Biomarkers; D002097:C-Reactive Protein; D003404:Creatinine; D008049:Lipase
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