Molecular mechanisms of chemoresistance in gastric cancer.
Gastric cancer is the fourth most common cancer and the second leading cause of cancer deaths worldwide. Chemotherapy is one of the major treatments for gastric cancer, but drug resistance limits the effectiveness of chemotherapy, which results in treatment failure. Resistance to chemotherapy can be present intrinsically before the administration of chemotherapy or it can develop during chemotherapy. The mechanisms of chemotherapy resistance in gastric cancer are complex and multifactorial. A variety of factors have been demonstrated to be involved in chemoresistance, including the reduced intracellular concentrations of drugs, alterations in drug targets, the dysregulation of cell survival and death signaling pathways, and interactions between cancer cells and the tumor microenvironment. This review focuses on the molecular mechanisms of chemoresistance in gastric cancer and on recent studies that have sought to overcome the underlying mechanisms of chemoresistance.
Wen-Jia Shi, Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China.
Wen-Jia
WJ
Shi
Wen-Jia Shi, Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China.
Jin-Bo
JB
Gao
Chemotherapy; Drug resistance; Gastric cancer
Mol Cell. 2016 Mar 3;61(5):695-704
26942674
Surg Today. 2012 Feb;42(3):225-32
22143356
BMC Cancer. 2005 Mar 23;5:29
15784156
Oncol Rep. 2010 Jul;24(1):113-9
20514451
FEBS Lett. 2013 Sep 17;587(18):3069-75
23932924
J Clin Oncol. 2006 Jun 20;24(18):2903-9
16782930
J Natl Cancer Inst. 1990 Feb 7;82(3):193-8
1967320
Int J Cancer. 2008 Jul 15;123(2):372-9
18449891
J Int Med Res. 2010 Jan-Feb;38(1):34-42
20233511
Int J Cancer. 2005 Nov 10;117(3):376-80
15900596
Eur J Pharmacol. 2014 Oct 15;741:140-9
25111243
J Cancer Res Ther. 2012 Jan-Mar;8(1):57-61
22531515
Oncogene. 2014 Jun 19;33(25):3267-76
23893241
World J Gastroenterol. 2012 Dec 7;18(45):6577-86
23236232
Oncogene. 2003 Jan 9;22(1):90-7
12527911
Anticancer Res. 1999 Nov-Dec;19(6B):5393-8
10697567
Cancer Lett. 2011 Dec 1;311(1):48-56
21752536
Asian Pac J Cancer Prev. 2014;15(16):6935-8
25169549
Int J Clin Oncol. 2013 Apr;18(2):293-304
22350022
Yonsei Med J. 1996 Dec;37(6):397-404
9048492
Oncol Rep. 2004 Jan;11(1):9-15
14654896
BMC Cancer. 2011 May 18;11:177
21586171
J Int Med Res. 1999 Mar-Apr;27(2):79-84
10446694
Gastric Cancer. 2017 Jan;20(1):164-174
26681196
Virchows Arch. 2008 Nov;453(5):449-55
18841391
BMC Cancer. 2008 Dec 18;8:375
19091131
Ann Oncol. 2004 Nov;15(11):1585-95
15520058
Oncotarget. 2015 Mar 10;6(7):5072-87
25669984
Int J Oncol. 2000 Apr;16(4):745-9
10717243
Oncol Rep. 2015 Jun;33(6):2746-52
25846650
Diagn Pathol. 2013 Dec 10;8:198
24326092
Am J Pathol. 1996 Sep;149(3):997-1007
8780403
Oncology. 2011;80(1-2):130-4
21677458
Cancer Chemother Pharmacol. 2013 May;71(5):1159-71
23423488
Int J Cancer. 2010 Dec 1;127(11):2520-9
20162574
Mol Med Rep. 2014 Dec;10(6):3275-81
25270341
Dig Dis Sci. 2011 Jan;56(1):131-8
20503071
J Exp Clin Cancer Res. 2007 Jun;26(2):261-8
17725107
World J Gastroenterol. 2015 Nov 7;21(41):11673-9
26556994
Cancer Chemother Pharmacol. 1994;34(3):203-8
8004752
Asian Pac J Cancer Prev. 2012;13(5):2379-83
22901225
J Exp Clin Cancer Res. 2011 May 13;30:55
21569481
Int J Surg Investig. 1999;1(1):3-10
11817335
Cancer Biol Ther. 2013 Oct 1;14(10):932-6
23917345
Cancer. 1994 Aug 15;74(4):1230-6
8055443
Br J Cancer. 2006 Jun 19;94(12):1894-7
16721363
Carcinogenesis. 1990 Sep;11(9):1593-6
2401049
World J Surg Oncol. 2014 Oct 11;12:307
25304659
Biomed Pharmacother. 2013 Sep;67(7):615-9
23684481
Am J Clin Pathol. 1990 Jan;93(1):1-7
1967201
World J Gastroenterol. 2007 Oct 7;13(37):5030-4
17854149
Cancer Lett. 2007 Jul 18;252(2):307-13
17303323
Mol Med Rep. 2014 Apr;9(4):1439-43
24549588
J Exp Clin Cancer Res. 2006 Dec;25(4):601-6
17310852
Hepatogastroenterology. 2012 Jun;59(116):1290-3
22281973
Oncol Rep. 2014 Jul;32(1):105-14
24840404
J Pathol. 2009 Jun;218(2):248-55
19274672
Cancer Genomics Proteomics. 2011 May-Jun;8(3):127-33
21518818
J Biomed Biotechnol. 2012;2012:891961
22919278
BMC Cancer. 2010 Aug 13;10 :425
20704765
Oncol Rep. 2009 Oct;22(4):693-9
19724845
Drug Resist Updat. 2003 Aug;6(4):169-72
12962682
Cell Death Differ. 2010 Apr;17(4):699-709
19851330
Semin Surg Oncol. 1994 Mar-Apr;10(2):135-9
7914378
J Clin Pathol. 1987 Dec;40(12):1418-23
3323249
Int J Oncol. 2013 Nov;43(5):1495-502
23970333
Int J Cancer. 2008 Jan 15;122(2):433-43
17935137
Braz J Med Biol Res. 2006 Apr;39(4):431-40
16612465
Hepatogastroenterology. 2013 Jan-Feb;60(121):213-6
22945336
Cancer Gene Ther. 2004 Nov;11(11):699-706
15375376
Cancer Sci. 2008 Jan;99(1):121-8
17953712
Cancer. 1993 Feb 1;71(3):667-71
8431845
Med Oncol. 2014 May;31(5):950
24722794
Biochem Biophys Res Commun. 2015 Jul 3;462(3):227-32
25956062
Eur J Cancer. 2005 Jul;41(11):1649-54
15994075
World J Gastroenterol. 2011 Oct 14;17(38):4289-97
22090785
Br J Cancer. 2002 May 20;86(10):1578-85
12085207
J Exp Clin Cancer Res. 2009 Nov 24;28:144
19930704
Jpn J Cancer Res. 1989 Oct;80(10):993-9
2575610
Cancer Chemother Pharmacol. 1998;41(5):353-60
9523730
CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90
21296855
PLoS One. 2010 Aug 10;5(8):e12038
20706634
Cell Death Dis. 2012 Nov 15;3:e423
23152059
Gastric Cancer. 2007;10(1):45-51
17334718
APMIS. 2003 Dec;111(12):1105-13
14678019
Hum Mutat. 2003 Mar;21(3):258-70
12619111
Adv Cancer Res. 2005;94:29-86
16095999
Int J Clin Exp Pathol. 2013 Oct 15;6(11):2554-9
24228120
PLoS One. 2014 Apr 16;9(4):e95371
24740294
Mol Med Rep. 2013 May;7(5):1387-90
23546174
N Engl J Med. 2006 Jul 6;355(1):11-20
16822992
Anticancer Res. 2000 May-Jun;20(3A):1705-10
10928096
Clin Cancer Res. 2009 Feb 15;15(4):1126-32
19228717
Cancer Sci. 2014 Jun;105(6):651-9
24703465
Int J Oncol. 2014 Feb;44(2):583-90
24337061
Dig Liver Dis. 2006 May;38(5):310-8
16527552
FEBS J. 2014 Jan;281(1):115-28
24165223