Interleukin-8 gene polymorphism -251T>A contributes to Alzheimer's disease susceptibility.
BACKGROUND
Published association studies have investigated the correlation between interleukin-8 (IL-8) gene polymorphism -251T>A and susceptibility to Alzheimer's disease (AD); however, the results are conflicting. Thus, we conducted the meta-analysis to reassess the effect of IL-8 gene -251T>A variant on the risk of AD.


METHODS
Relevant studies regarding this association were electronically searched and identified from the PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, and the Chinese Biomedicine Database. The odds ratios (ORs) with the corresponding 95% confidence intervals (95% CIs) were pooled to calculate the strength of this association.


RESULTS
Nine studies with a total of 1406 cases and 2152 controls were included in the meta-analysis. Overall, a significant association of IL-8 gene -251T>A polymorphism with increased risk of AD was observed in several genetic models (allele, A vs T: OR=1.32, 95%CI=1.16-1.50; homozygous, AA vs TT: OR=1.70, 95%CI=1.21-2.21; heterozygous, TA vs TT: OR=1.37, 95%CI=1.12-1.69; recessive, AA vs TA+TT: OR=1.40, 95%CI=1.12-1.75). Similarly, such association was also revealed both in Asian and European populations in the subgroup analysis by ethnicity.


CONCLUSIONS
The current study suggested that IL-8 gene polymorphism -251T>A may contribute to the susceptibility to AD.
aDepartment of Neurology bDepartment of Nursing cDepartment of Public Health dDepartment of Cardiology eDepartment of Spinal Surgery fDepartment of Ultrasonography, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
Biyong
B
Qin
Li
L
Li
Shanshan
S
Wang
Jun
J
Wu
Yulan
Y
Huang
Ping
P
Zhou
Jiao
J
Bai
Yan
Y
Zheng
D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism; D004247:DNA / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D016209:Interleukin-8 / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic
D016209:Interleukin-8; D004247:DNA
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