Atypical psychotic symptoms and Dandy-Walker variant.
New-onset psychotic symptoms often respond well to antipsychotic treatment; however, symptoms may be difficult to treat when an underlying brain malformation is present. Here, we present a case of atypical psychotic symptoms in the context of a congenital cerebellar malformation (Dandy-Walker variant). The patient ultimately improved with paliperidone palmitate after multiple antipsychotic medication trials (both oral and one long-acting injectable) were ineffective. Neuroimaging may provide valuable diagnostic and prognostic information in cases of new-onset psychosis with atypical features and treatment resistance, even in the absence of neurologic signs and symptoms.
a Department of Psychiatry , University of Michigan , Ann Arbor , MI , USA.
Aislinn J
AJ
Williams
a Department of Psychiatry , University of Michigan , Ann Arbor , MI , USA.
Zhenni
Z
Wang
a Department of Psychiatry , University of Michigan , Ann Arbor , MI , USA.
Stephan F
SF
Taylor
D014150:Antipsychotic Agents / Q000627:therapeutic use; D003616:Dandy-Walker Syndrome / Q000150:complications* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D000068882:Paliperidone Palmitate / Q000627:therapeutic use; D011618:Psychotic Disorders / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D055815:Young Adult
D014150:Antipsychotic Agents; D000068882:Paliperidone Palmitate
Dandy–Walker; Schizophrenia; cerebellum; psychosis; treatment resistant