Effect of Ramadan fasting on metabolic markers, dietary intake and abdominal fat distribution in pregnancy.
BACKGROUND
The aim of this study is to evaluate the effect of Ramadan intermittent fasting on metabolic markers, dietary intake, anthropometric measurements, and abdominal visceral fat thickness (VFT) in pregnancy.


METHODS
Seventy-eight healthy pregnant subjects who had fasted for at least 15 days during the month of Ramadan in 2012 and 2013 and 78 controls were included in this study. Metabolic markers, dietary intake, anthropometric measurements, and ultrasonographic VFT were calculated for each subject before and after Ramadan fasting.


RESULTS
When before and after Ramadan values in the fasting group were compared, we found that daily protein intake was increased (p <0.001), but fat and carbohydrate intake remained unchanged. A significant reduction was observed in liquid consumption while the frequency of asymptomatic bacteriuria was increased. High-density lipoprotein significantly increased, and glycated hemoglobin, insulin, and homeostasis model index significantly decreased (p =0.005, p =0.01, p <0.001, and p =0.03, respectively). A significant increase in ferritin was found (p =0.02). No change was observed in subcutaneous fat thickness, while VFT significantly decreased (p =0.08, p =0.005). However, in the control group, only ferritin level increased.


CONCLUSIONS
A combined change in the number and timing of meals and the portioning of the entire daily intake into only two meals per day may have beneficial metabolic effects and reduction in VFT during pregnancy. Hippokratia 2015; 19 (4): 298-303.
Department of Obstetrics and Gynecology, Faculty of Medicine, Katip Celebi University, Izmir, Turkey.
E B
EB
Gur
Department of Obstetrics and Gynecology, Faculty of Medicine, Sifa University, Izmir, Turkey.
G A
GA
Turan
Department of Radiology, Faculty of Medicine, Sifa University, Izmir, Turkey.
O
O
Ince
Department of Endocrinology, Faculty of Medicine, Sifa University, Izmir, Turkey.
M
M
Karadeniz
Department of Obstetrics and Gynecology, Faculty of Medicine, Sifa University, Izmir, Turkey.
S
S
Tatar
Department of Obstetrics and Gynecology, Faculty of Medicine, Sifa University, Izmir, Turkey.
E
E
Kasap
Department of Obstetrics and Gynecology, Faculty of Medicine, Sifa University, Izmir, Turkey.
N
N
Sahin
Department of Obstetrics and Gynecology, Faculty of Medicine, Sifa University, Izmir, Turkey.
S
S
Guclu
Ramadan fasting; abdominal visceral fat thickness; metabolic markers; pregnancy
Diabetes Metab Syndr Obes. 2011;4:409-16
22253539
Diabetes Care. 2004 Oct;27(10):2306-11
15451892
Singapore Med J. 2006 May;47(5):409-14
16645692
Endocrine. 2014 Nov;47(2):478-84
24452873
Atherosclerosis. 2009 Jan;202(1):192-9
18533157
Tohoku J Exp Med. 2004 Nov;204(3):179-87
15502416
Am J Epidemiol. 2009 Oct 1;170(7):829-36
19713286
Obesity (Silver Spring). 2006 Feb;14 Suppl 1:16S-19S
16642958
Appl Physiol Nutr Metab. 2009 Aug;34(4):587-94
19767792
J Matern Fetal Neonatal Med. 2012 Jul;25(7):975-7
21740320
Br J Nutr. 2008 Jul;100(1):147-51
18053308
Pregnancy Hypertens. 2011 Jan 1;1(1):6-16
21532964
Ann Nutr Metab. 2010;56(4):273-82
20424438
Ultrasound Med Biol. 2010 Nov;36(11):1769-75
20870342
Diabetes Care. 2005 Sep;28(9):2305-11
16123509
J Obstet Gynaecol Res. 2008 Aug;34(4):494-8
18937702
Endocrinology. 2004 May;145(5):2273-82
14726444
Med J Malaysia. 2003 Dec;58(5):678-80
15190653
J Hum Nutr Diet. 2013 Jul;26 Suppl 1:97-104
23679071