Altered Striatocerebellar Metabolism and Systemic Inflammation in Parkinson's Disease.
Parkinson's disease (PD) is the most second common neurodegenerative movement disorder. Neuroinflammation due to systemic inflammation and elevated oxidative stress is considered a major factor promoting the pathogenesis of PD, but the relationship of structural brain imaging parameters to clinical inflammatory markers has not been well studied. Our aim was to evaluate the association of magnetic resonance spectroscopy (MRS) measures with inflammatory markers. Blood samples were collected from 33 patients with newly diagnosed PD and 30 healthy volunteers. MRS data including levels of N-acetylaspartate (NAA), creatine (Cre), and choline (Cho) were measured in the bilateral basal ganglia and cerebellum. Inflammatory markers included plasma nuclear DNA, plasma mitochondrial DNA, and apoptotic leukocyte levels. The Cho/Cre ratio in the dominant basal ganglion, the dominant basal ganglia to cerebellum ratios of two MRS parameters NAA/Cre and Cho/Cre, and levels of nuclear DNA, mitochondrial DNA, and apoptotic leukocytes were significantly different between PD patients and normal healthy volunteers. Significant positive correlations were noted between MRS measures and inflammatory marker levels. In conclusion, patients with PD seem to have abnormal levels of inflammatory markers in the peripheral circulation and deficits in MRS measures in the dominant basal ganglion and cerebellum.
Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83305, Taiwan.
Chiun-Chieh
0000-0003-0936-7346
CC
Yu
Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83305, Taiwan.
Meng-Hsiang
0000-0003-0201-9015
MH
Chen
Department of Neurology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83305, Taiwan.
Cheng-Hsien
0000-0002-5716-3930
CH
Lu
Department of Nuclear Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83305, Taiwan.
Yung-Cheng
0000-0001-5609-9765
YC
Huang
Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83305, Taiwan.
Hsiu-Ling
HL
Chen
Department of Neurology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83305, Taiwan.
Nai-Wen
NW
Tsai
Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83305, Taiwan.
Hung-Chen
0000-0003-3962-1958
HC
Wang
Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83305, Taiwan.
I-Hsiao
0000-0003-3952-4963
IH
Yang
Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83305, Taiwan.
Shau-Hsuan
0000-0002-7140-9132
SH
Li
Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83305, Taiwan.
Wei-Che
0000-0002-5258-8569
WC
Lin
Neurosci Lett. 2007 Sep 13;424(3):185-9
17714864
Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):E1826-34
26976580
Mov Disord. 2004 Sep;19(9):1020-8
15372591
J Neurosci. 2001 Jan 15;21(2):700-12
11160449
J Transl Med. 2015 Dec 21;13:386
26692087
Curr Metabolomics. 2013;1(3):191-209
26078917
Biochim Biophys Acta. 2000 Aug 15;1459(2-3):397-404
11004456
Mov Disord. 2007 Nov 15;22(15):2170-5
17722082
Clin Chem. 2003 May;49(5):719-26
12709361
Oxid Med Cell Longev. 2015;2015:610813
25834699
Front Cell Neurosci. 2013 Sep 10;7:150
24058335
Parkinsonism Relat Disord. 2015 Aug;21(8):929-37
26077167
Brain. 2012 Nov;135(Pt 11):3206-26
22382359
Mov Disord. 2002 Sep;17(5):867-76
12360535
Brain Imaging Behav. 2014 Mar;8(1):97-101
23955491
Arch Neurol. 2002 Sep;59(9):1415-20
12223027
Brain Behav Immun. 2013 Oct;33:183-9
23911592
Parkinsonism Relat Disord. 2013 Mar;19(3):329-34
23238068
Mov Disord. 2002 Sep;17(5):917-27
12360540
Neuropathol Appl Neurobiol. 2009 Apr;35(2):132-46
19077110
Am J Hum Genet. 1998 Apr;62(4):768-75
9529358
Neurol Sci. 2001 Feb;22(1):83-4
11487213
Glia. 2007 Apr 1;55(5):453-62
17203472
Brain. 2016 Mar;139(Pt 3):845-55
26794597
Funct Integr Genomics. 2011 Dec;11(4):523-37
21892731
Biomed Res Int. 2014;2014:635923
24795890
Cell Transplant. 2008;17(4):363-72
18522239
Brain. 2013 Mar;136(Pt 3):696-709
23404337
BMC Res Notes. 2016 Apr 19;9:226
27094345
Biomed Res Int. 2014;2014:519816
25302300
Am J Nephrol. 2012;36(6):531-6
23258075
Curr Opin Neurobiol. 1996 Oct;6(5):661-6
8937831
J Neuroimmune Pharmacol. 2013 Jun;8(3):576-93
23666436
J Psychiatr Res. 1975 Nov;12(3):189-98
1202204
Neurology. 1998 Apr;50(4):1033-40
9566391
Brain Res Bull. 1998 Jul 1;46(4):281-309
9671259
Ther Adv Neurol Disord. 2014 Jul;7(4):206-20
25002908
Comput Struct Biotechnol J. 2015 Mar 28;13:212-21
25893083
Neurotoxicology. 2012 Jun;33(3):347-60
22330755
Neurology. 1992 Jun;42(6):1142-6
1603339
J Neurochem. 2008 May;105(3):666-76
18088374
Free Radic Biol Med. 2013 Sep;62:90-101
23200807
Prog Neurobiol. 2014 Jan;112:24-49
24211851
J Neurosurg. 2013 Jan;118(1):13-9
23020765
Mol Cancer. 2009 Nov 17;8:105
19922604
Brain. 1997 Sep;120 ( Pt 9):1541-52
9313638
CNS Neurol Disord Drug Targets. 2015;14(3):313-24
25714978
DNA Cell Biol. 2011 Jun;30(6):389-94
21329459
Ann Neurol. 1995 Feb;37(2):204-10
7847862
J Neurol Sci. 2007 Jun 15;257(1-2):221-39
17462670
Front Cell Neurosci. 2015 Feb 02;9:28
25698933
Antioxid Redox Signal. 2009 Sep;11(9):2151-66
19243239
Brain Pathol. 2014 Nov;24(6):654-64
25345895
Nat Methods. 2015 Oct;12(10):899-900
26688882
Parkinsons Dis. 2011;2011:393769
21603178
Int J Environ Res Public Health. 2011 Dec;8(12 ):4702-13
22408597
Neurobiol Aging. 2003 Mar-Apr;24(2):197-211
12498954
Neurobiol Aging. 2016 Feb;38:216.e7-10
26639155
Magn Reson Med. 1995 May;33(5):589-94
7596261
J Transl Med. 2016 May 17;14(1):139
27188598
Neurobiol Dis. 2006 Jul;23(1):36-43
16563783
Neuroradiology. 2015 Mar;57(3):327-34
25479963