Changes of Femoral Photolethysmographic Waveform Characteristics in Anesthetized Dogs with Increased Blood Pressure Induced by Epinephrine.
BACKGROUND
Blood pressure (BP) has been proven to play an important role in changes of the morphology of a pulse waveform. However, the extent of change of the morphology because of BP signaling has yet to be accurately confirmed.


OBJECTIVE
This study aims to disclose the accurate effect of BP on the changes in the morphology of the pulse waveform.


METHODS
Two dogs' invasive intraventricular BP (varied by ejecting different doses of epinephrine) and their femoral arterial pulse waveform (FAPW) signals were synchronously recorded. For each BP increase, a normalized single cardiac beat pulse from the FAPW signal was fitted by five Gaussian curves and the changes in the Gaussian parameters (height, peak position, and time support) were observed.


RESULTS
The height parameter increased while the position and time support parameters decreased with increasing systolic BP (SBP). The height ratio and the peak intervals between the first two components decreased with increasing SBP.


CONCLUSIONS
These results may contribute to the better understanding of the underlying changes of arterial pulse properties at different BP levels and demonstrate the potential application value of the Gaussian fitting method for clinically assessing pulse morphology and evaluating the well-being of artery system.
Department of Biomedical Engineering, Dalian University of Technology Dalian, China.
Hong
H
Tang
Institute of Biomedical Engineering, School of Control Science and Engineering, Shandong University Jinan, China.
Chengyu
C
Liu
Gaussian fitting model; blood pressure; correlation analysis; femoral artery pulse; pulse waveform morphology
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