Quaternized chitosan/κ-carrageenan/caffeic acid-coated poly(3-hydroxybutyrate) fibrous materials: Preparation, antibacterial and antioxidant activity.
Novel fibrous materials with antioxidant and antibacterial properties from poly(3-hydroxybutyrate) (PHB), quaternized chitosan (QCh), κ-carrageenan (Car) and caffeic acid (CA) were obtained. These materials were prepared by applying electrospinning or electrospinning in conjunction with dip-coating and polyelectrolyte complex (PEC) formation. It was found that the CA release depended on the fiber composition. X-ray diffraction analysis (XRD) and differential scanning calorimetry (DSC) revealed that CA incorporated in the fibers was in the amorphous state, whereas CA included in the coating was in the crystalline state. In contrast to the neat PHB mats, the CA-containing mats and the PEC QCh/Car-coated mats were found to kill the Gram-positive bacteria S. aureus and the Gram-negative bacteria E. coli and were effective in suppressing the adhesion of pathogenic bacteria S. aureus. Enhancement of the antioxidant activity of the fibrous materials containing both CA and QCh/Car coating was observed.
Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev St, Bl. 103A, BG-1113 Sofia, Bulgaria.
Milena
M
Ignatova
Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev St, Bl. 103A, BG-1113 Sofia, Bulgaria. Electronic address: manolova@polymer.bas.bg.
Nevena
N
Manolova
Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev St, Bl. 103A, BG-1113 Sofia, Bulgaria.
Iliya
I
Rashkov
Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Bl. 26, BG-1113 Sofia, Bulgaria.
Nadya
N
Markova
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry*; D000975:Antioxidants / Q000008:administration & dosage / Q000737:chemistry*; D001422:Bacterial Adhesion; D001713:Biphenyl Compounds / Q000737:chemistry; D002109:Caffeic Acids / Q000008:administration & dosage / Q000737:chemistry*; D002351:Carrageenan / Q000008:administration & dosage / Q000737:chemistry*; D048271:Chitosan / Q000008:administration & dosage / Q000737:chemistry*; D004339:Drug Compounding; D016503:Drug Delivery Systems; D065546:Drug Liberation; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D006885:Hydroxybutyrates / Q000008:administration & dosage / Q000737:chemistry*; D010851:Picrates / Q000737:chemistry; D000071228:Polyelectrolytes / Q000008:administration & dosage / Q000737:chemistry; D011091:Polyesters / Q000008:administration & dosage / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development / Q000502:physiology; D000094122:Polyhydroxybutyrates
D000900:Anti-Bacterial Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D002109:Caffeic Acids; D002351:Carrageenan; D048271:Chitosan; D006885:Hydroxybutyrates; D010851:Picrates; D000071228:Polyelectrolytes; D011091:Polyesters; C003182:poly-beta-hydroxybutyrate; D000094122:Polyhydroxybutyrates; C004931:1,1-diphenyl-2-picrylhydrazyl; C040048:caffeic acid
Antibacterial fibers; Antioxidant activity; Caffeic acid; Electrospinning; Quaternized chitosan; κ-Carrageenan