Garcinol and Its Role in Chronic Diseases.
The various bioactive compounds isolated from leaves and fruits of Garcinia sps plants, have been characterized and experimentally demonstrated to be anti-oxidant, anti-inflammatory and anti-cancer in nature. Garcinol, a polyisoprenylated benzophenone, obtained from plant Garcinia indica has been found to be an effective inhibitor of several key regulatory pathways (e.g., NF-kB, STAT3 etc.) in cancer cells, thereby being able to control malignant growth of solid tumours in vivo. Despite its high potential as an anti-neoplastic modulator of several cancer types such as head and neck cancer, breast cancer, hepatocellular carcinoma, prostate cancer, colon cancer etc., it is still in preclinical stage due to lack of systematic and conclusive evaluation of pharmacological parameters. While it is promising anti-cancer effects are being positively ascertained for therapeutic development, studies on its effectiveness in ameliorating other chronic diseases such as cardiovascular diseases, diabetes, allergy, neurodegenerative diseases etc., though seem favourable, are very recent and require in depth scientific investigation.
Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur P.O., Bangalore, 560064, India.
Amit K
AK
Behera
Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur P.O., Bangalore, 560064, India.
Mahadeva M
MM
Swamy
Central Government Health Scheme Dispensary, No. 3, Basavanagudi, Bangalore, India.
Nagashayana
N
Natesh
Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur P.O., Bangalore, 560064, India. tapas@jncasr.ac.in.
Tapas K
TK
Kundu
D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy; D002908:Chronic Disease; D003920:Diabetes Mellitus / Q000188:drug therapy; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D015398:Signal Transduction / Q000187:drug effects; D013729:Terpenes / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*
D013729:Terpenes; C054597:garcinol
Epigenetic enzymes; Inflammation; STAT3; Tumorigenesis