Rough Gold Electrodes for Decreasing Impedance at the Electrolyte/Electrode Interface.
Electrode polarization at the electrolyte/electrode interface is often undesirable for bio-sensing applications, where charge accumulated over an electrode at constant potential causes large potential drop at the interface and low measurement sensitivity. In this study, novel rough electrodes were developed for decreasing electrical impedance at the interface. The electrodes were fabricated using electrochemical deposition of gold and sintering of gold nanoparticles. The performances of the gold electrodes were compared with platinum black electrodes. A constant phase element model was used to describe the interfacial impedance. Hundred folds of decrease in interfacial impedance were observed for fractal gold electrodes and platinum black. Biotoxicity, contact angle, and surface morphology of the electrodes were investigated. Relatively low toxicity and hydrophilic nature of the fractal and granulated gold electrodes make them suitable for bioimpedance and cell electromanipulation studies compared to platinum black electrodes which are both hydrophobic and toxic.
Department of Mechanical Engineering, Southern Methodist University, Dallas, TX, 75205, USA.
Anil
A
Koklu
Department of Mechanical Engineering, Southern Methodist University, Dallas, TX, 75205, USA.
Ahmet C
AC
Sabuncu
Department of Mechanical Engineering, Southern Methodist University, Dallas, TX, 75205, USA.
Ali
A
Beskok
Bioimpedance; Dielectric Spectroscopy; Electrode polarization; Fractal Electrodes; Microfluidics
Colloids Surf B Biointerfaces. 2012 Jun 15;95:96-102
22421416
J Colloid Interface Sci. 1997 Oct 1;194(1):225-38
9367601
Nanomedicine (Lond). 2006 Aug;1(2):219-28
17716111
Adv Drug Deliv Rev. 2011 Nov;63(14-15):1361-70
22016112
Curr Opin Chem Biol. 2012 Aug;16(3-4):429-35
22541663
Rev Sci Instrum. 2010 Jan;81(1):016104
20113135
Phys Rev Lett. 1985 Jul 29;55(5):529-532
10032377
Phys Rev B Condens Matter. 1990 Jul 1;42(1):709-719
9994592
Chem Soc Rev. 2006 Nov;35(11):1084-94
17057837
J Pharm Sci. 2005 May;94(5):1090-100
15793811
Langmuir. 2006 Mar 14;22(6):2851-5
16519494
Biosens Bioelectron. 2013 Nov 15;49:348-59
23796534
Physiol Meas. 2011 Feb;32(2):195-205
21178248
Rev Sci Instrum. 2012 Aug;83(8):083118
22938285
Electrophoresis. 2013 Apr;34(7):1051-8
23348751
Biomed Mater. 2008 Sep;3(3):034124
18765899
Ann N Y Acad Sci. 1968 Feb 1;148(1):191-209
5237641
Biophysik. 1966;3(2):181-201
5982795
Adv Mater. 2013 Jul 12;25(26):3566-70
23716475
Conf Proc IEEE Eng Med Biol Soc. 2013;2013:184-7
24109655
Chemphyschem. 2014 Jun 6;15(8):1550-61
24643996
Nanoscale. 2012 Jun 21;4(12):3786-90
22622685
Curr Opin Chem Biol. 2012 Aug;16(3-4):415-21
22771285
J Neurosci Methods. 1999 Feb 1;87(1):45-56
10065993
Biomaterials. 2008 Mar;29(9):1273-83
18093644
IEEE Trans Biomed Eng. 2005 Jul;52(7):1295-302
16041993
Lab Chip. 2010 Oct 21;10(20):2787-95
20725680
J Neurosci Methods. 1999 Oct 30;93(1):61-7
10598865
J Laryngol Otol. 2014 Aug;128(8):679-89
25084097
Phys Rev Lett. 1992 Jun 22;68(25):3741-3744
10045785
Conf Proc IEEE Eng Med Biol Soc. 2006;1:2239-42
17945701