Addressing the inter-individual variation in response to consumption of plant food bioactives: Towards a better understanding of their role in healthy aging and cardiometabolic risk reduction.
Bioactive compounds in plant-based foods have health properties that contribute to the prevention of age-related chronic diseases, particularly cardiometabolic disorders. Conclusive proof and understanding of these benefits in humans is essential in order to provide effective dietary recommendations but, so far, the evidence obtained from human intervention trials is limited and contradictory. This is partly due to differences between individuals in the absorption, distribution, metabolism and excretion of bioactive compounds, as well as to heterogeneity in their biological response regarding cardiometabolic health outcomes. Identifying the main factors underlying inter-individual differences, as well as developing new and innovative methodologies to account for such variability constitute an overarching goal to ultimately optimize the beneficial health effects of plant food bioactives for each and every one of us. In this respect, this position paper from the COST Action FA1403-POSITIVe examines the main factors likely to affect the individual responses to consumption of plant food bioactives and presents perspectives for assessment and consideration of inter-individual variability.
INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand; Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000, Clermont-Ferrand, France.
Claudine
C
Manach
INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand; Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000, Clermont-Ferrand, France.
Dragan
D
Milenkovic
Center for Microbial Ecology and Technology (CMET), Ghent University, Ghent, Belgium.
Tom
T
Van de Wiele
Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, University of Düsseldorf, Germany.
Ana
A
Rodriguez-Mateos
Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK.
Baukje
B
de Roos
Research Group on Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, Campus de Espinardo, Murcia, Spain.
Maria Teresa
MT
Garcia-Conesa
Department of Food Science, Swedish University of Agricultural Sciences, Uppsala, Sweden.|Nutritional Epidemiology Unit, Institute of Environmental Medicine, Karolinska Institutet, Solna, Sweden.
Rikard
R
Landberg
UCD Institute of Food and Health, University College Dublin, Dublin, Republic of Ireland.
Eileen R
ER
Gibney
Department of Food and Environmental Sciences, Food Chemistry, University of Helsinki, Finland.
Marina
M
Heinonen
Research Group on Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, Campus de Espinardo, Murcia, Spain.
Francisco
F
Tomás-Barberán
INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand; Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000, Clermont-Ferrand, France.
Christine
C
Morand
D002318:Cardiovascular Diseases / Q000517:prevention & control*; D004032:Diet; D000072001:Diet, Healthy; D015438:Health Behavior; D000073656:Healthy Aging; D006801:Humans; D008659:Metabolic Diseases / Q000517:prevention & control*; D064209:Phytochemicals / Q000032:analysis*; D010945:Plants, Edible / Q000737:chemistry*; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D040242:Risk Reduction Behavior
D064209:Phytochemicals
Bioavailability and metabolism; Biological responsiveness; Cardiometabolic health; Inter-individual variation; Plant food bioactives
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