G-Quadruplexes in DNA Replication: A Problem or a Necessity?
DNA replication is a highly regulated process that ensures the correct duplication of the genome at each cell cycle. A precise cell type-specific temporal program controls the duplication of complex vertebrate genomes in an orderly manner. This program is based on the regulation of both replication origin firing and replication fork progression. G-quadruplexes (G4s), DNA secondary structures displaying noncanonical Watson-Crick base pairing, have recently emerged as key controllers of genome duplication. Here we discuss the various means by which G4s affect this fundamental cellular process.
Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA 01605-0103, USA.
Anne-Laure
AL
Valton
Institut Jacques Monod, CNRS UMR7592, Université Paris Diderot, Equipe Labellisée Association pour la Recherche sur le Cancer, Paris 75013, France. Electronic address: marie-noelle.prioleau@ijm.fr.
Marie-Noëlle
MN
Prioleau
D020029:Base Pairing / Q000235:genetics; D002453:Cell Cycle / Q000235:genetics; D019070:Cell Lineage / Q000235:genetics; D004247:DNA / Q000235:genetics*; D004261:DNA Replication / Q000235:genetics*; D054856:G-Quadruplexes; D016678:Genome; D009690:Nucleic Acid Conformation; D018741:Replication Origin / Q000235:genetics
D004247:DNA
DNA replication; G-quadruplex; genetic and epigenetic instability; helicase; replication origin; specialized polymerase