Impact of current cough on health-related quality of life in patients with COPD.
BACKGROUND
Cough and sputum production are frequent in chronic obstructive pulmonary disease (COPD). The objective of this study was to examine the relationship between cough and sputum production and health-related quality of life in COPD.


METHODS
A cross-sectional study was conducted in the French Initiatives COPD cohort and assessed cough and sputum production within the past 7 days using the cough and sputum assessment questionnaire (CASA-Q), health-related quality of life, spirometry, smoking status, dyspnea, exacerbations, anxiety and depression, and comorbidities.


RESULTS
One hundred and seventy-eight stable COPD patients were included (age, 62 [56-69] years, 128 male, forced expiratory volume in 1 second [FEV1]: 57 [37-72] % predicted) (median [Q1-Q3]). In univariate analyses, health-related quality of life (Saint George's respiratory questionnaire total score) was associated with each CASA-Q domain and with chronic bronchitis, exacerbations, dyspnea, FEV1, depression, and anxiety. All four domains introduced separately were independently associated with health-related quality of life. When introduced together in multivariate analyses, only the cough impact domain remained independently associated with health-related quality of life (R2=0.60). With chronic bronchitis (standard definition) instead of the CASA-Q, theR2was lower (R2=0.54).


CONCLUSIONS
This study provides evidence that current cough in the previous 7 days is an important determinant of health-related quality of life impairment in stable COPD patients.
Department of Respiratory Diseases, INSERM UMR 903, Maison Blanche Hospital, University Hospital of Reims, Reims.
Gaëtan
G
Deslee
Department of Respiratory Diseases, Cochin Hospital, AP-HP and University Paris Descartes, Sorbonne Paris Cité, Paris.
Pierre-Régis
PR
Burgel
Department of Respiratory Diseases, Larrey Hospital, Toulouse.
Roger
R
Escamilla
Department of Respiratory Diseases, APHM, INSERM U1077, CNRS UMR 7733 Aix Marseille Université, Marseille.
Pascal
P
Chanez
Department of Respiratory Diseases, University Hospital of St Etienne.
Isabelle
I
Court-Fortune
Department of Respiratory Diseases, La Croix Rousse Hospital, Lyon.
Pascale
P
Nesme-Meyer
Department of Respiratory Diseases, Pontchaillou Hospital, University Hospital of Rennes, Rennes.
Graziella
G
Brinchault-Rabin
Department of Respiratory Diseases, Calmette Hospital, University Hospital of Lille, Lille.
Thierry
T
Perez
Department of Respiratory Diseases, Bichat Hospital, AP-HP, Paris.
Gilles
G
Jebrak
Department of Respiratory Diseases, Gabriel Montpied Hospital, University Hospital of Clermont-Ferrand, Clermont-Ferrand.
Denis
D
Caillaud
EFFI-STAT, Paris, France.
Jean-Louis
JL
Paillasseur
Department of Respiratory Diseases, Cochin Hospital, AP-HP and University Paris Descartes, Sorbonne Paris Cité, Paris.
Nicolas
N
Roche
D000368:Aged; D015897:Comorbidity; D003371:Cough / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000523:psychology*; D003430:Cross-Sectional Studies; D005260:Female; D005541:Forced Expiratory Volume; D005602:France; D006304:Health Status; D006785:Hospitals, University; D006801:Humans; D008168:Lung / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology*; D011788:Quality of Life; D012307:Risk Factors; D013147:Spirometry; D013183:Sputum; D011795:Surveys and Questionnaires; D013997:Time Factors
dyspnea; multivariate analysis; questionnaires; respiratory; signs and symptoms; sputum
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