Predictive value of sICAM-1 and sVCAM-1 as biomarkers of affective temperaments in healthy young adults.
Affective temperaments are intermediate phenotypes for major affective disorders and are reported to have a neuroimmune etiopathogenesis. Here we investigated the role of soluble intercellular cell adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in affective temperaments and mood symptoms in healthy adults.



Healthy adults (n=94) were screened for psychiatric disorders using the nonpatient version of the Structured Clinical Interview for DSM-IV-I and II. Subjects with medical conditions associated with changes in inflammatory response were excluded, deriving the final sample (n=68). Affective temperaments were evaluated with Temperament Evaluation of Memphis, Pisa, Paris and San Diego-Autoquestionnaire (TEMPS-A). State mood symptoms were assessed using the Young Mania Rating Scale and Montgomery-Åsberg Depression Rating Scale. Serum sICAM-1 and sVCAM-1 levels were measured using enzyme-linked immunosorbent assay.



After adjusting for confounders (age, gender, BMI, and smoking habits), a high negative correlation between depressive and irritable temperament TEMPS-A scores and sVCAM-1 levels was detected. Although we identified no association between sICAM-1 levels and affective temperament scores, sICAM-1 was related to the state severity of manic symptoms. In a multiple linear regression model, sVCAM-1 remained a significant predictor of depressive but not irritable temperament scores.



The temperaments were estimated on the basis of self-report questionnaire.



Our findings suggest that sVCAM-1 is related to affective temperaments, and it is a trait marker for liability to mood disorders. This relationship between alterations in cellular adhesion and affective temperament may be important for vulnerability to affective disorders.
Clinic of Psychiatry, Clinical Centre of Serbia, Pasterova 2, 11000 Belgrade, Serbia; School of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia.
Maja
M
Ivković
Clinic of Psychiatry, Clinical Centre of Serbia, Pasterova 2, 11000 Belgrade, Serbia. Electronic address: majapantovic@yahoo.it.
Maja
M
Pantović-Stefanović
School of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia; Institute of Clinical and Medical Biochemistry, Pasterova 2, 11000 Belgrade, Serbia.
Nataša
N
Petronijević
Clinic of Psychiatry, Clinical Centre of Serbia, Pasterova 2, 11000 Belgrade, Serbia.
Bojana
B
Dunjić-Kostić
School of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia; Institute of Clinical and Medical Biochemistry, Pasterova 2, 11000 Belgrade, Serbia.
Milica
M
Velimirović
School of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia; Institute of Clinical and Medical Biochemistry, Pasterova 2, 11000 Belgrade, Serbia.
Tatjana
T
Nikolić
School of Medicine, University of Kragujevac, Svetozara Markovica 69, 11000 Kragujevac, Serbia.
Vladimir
V
Jurišić
Clinic of Psychiatry, Clinical Centre of Serbia, Pasterova 2, 11000 Belgrade, Serbia; School of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia.
Maja
M
Lačković
Clinic of Psychiatry, Clinical Centre of Serbia, Pasterova 2, 11000 Belgrade, Serbia; School of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia.
Sanja
S
Totić-Poznanović
Clinic of Psychiatry, Clinical Centre of Serbia, Pasterova 2, 11000 Belgrade, Serbia; School of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia.
Aleksandar A
AA
Jovanović
Clinic of Psychiatry, Clinical Centre of Serbia, Pasterova 2, 11000 Belgrade, Serbia; School of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia.
Aleksandar
A
Damjanović
D000328:Adult; D000339:Affect; D015415:Biomarkers / Q000097:blood; D001714:Bipolar Disorder / Q000097:blood; D003863:Depression / Q000097:blood*; D003865:Major Depressive Disorder / Q000097:blood; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D007508:Irritable Mood; D016014:Linear Models; D008297:Male; D019964:Mood Disorders / Q000097:blood; D057566:Self Report; D011795:Surveys and Questionnaires; D013694:Temperament; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
D015415:Biomarkers; C573420:ICAM1 protein, human; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1
Affective temperaments; Cellular adhesion; Mood disorders; Personality; sICAM-1; sVCAM-1