Environmental pollutants: genetic damage and epigenetic changes in male germ cells.
About a quarter of the human diseases occurs for exposure to air pollution. The male reproductive system, and especially spermatogenesis, seems to be particularly sensitive. As result, male infertility is increasing in industrial countries becoming a top priority for public health. In addition to psychological distress and economic constraints, poorer semen quality may have trans-generational effects including congenital malformations in the offspring and predispose to later onset adult diseases. Genetic and epigenetic alterations are involved in the failure of spermatogenesis. In this paper, we reviewed the major evidences of the effects of air pollutants on male infertility as well as the role of sperm DNA damage and epigenetic changes in affecting spermatogenesis. A better knowledge on the effects of air contaminants on the molecular mechanisms leading to infertility is of huge importance to help clinicians in identifying the cause of infertility but above all, in defining preventive and therapeutic protocols.
Institute of Clinical Physiology-CNR, via G.Moruzzi 1, 56124, Pisa, Italy. vecoli@ifc.cnr.it.
Cecilia
C
Vecoli
Andrology Unit of the "San Francesco d'Assisi" Hospital - ASL Salerno, EcoFoodFertility Project Coordination Unit, via M. Clemente, 84020, Oliveto Citra, SA, Italy.
Luigi
L
Montano
Institute of Clinical Physiology-CNR, via G.Moruzzi 1, 56124, Pisa, Italy.
Maria Grazia
MG
Andreassi
D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D004249:DNA Damage; D044127:Epigenesis, Genetic / Q000187:drug effects*; D006801:Humans; D007248:Infertility, Male / Q000139:chemically induced*; D008297:Male; D051379:Mice; D051381:Rats; D013091:Spermatogenesis / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects*
D000393:Air Pollutants
Environmental pollutants; Epigenetics; Genetics; Infertility; Male germ cells; Spermatogenesis
Hum Reprod Update. 2000 Mar-Apr;6(2):107-21
10782569
J Androl. 2012 Nov-Dec;33(6):1394-401
22837112
Hum Reprod. 2009 Sep;24(9):2361-4
19477879
Reprod Toxicol. 2016 Dec;66:1-9
27592743
Hum Reprod. 2000 Jun;15(6):1338-44
10831565
Environ Health Perspect. 2006 Mar;114(3):360-5
16507458
Prog Biophys Mol Biol. 2011 Dec;107(3):315-22
21906619
Lancet. 2000 Oct 7;356(9237):1240-1
11072947
Mol Hum Reprod. 2008 Feb;14(2):67-74
18178607
PLoS One. 2010 Nov 09;5(11):e13884
21085488
Fertil Steril. 2003 Apr;79(4):829-43
12749418
Genome Res. 2011 Dec;21(12):2058-66
22042642
Reproduction. 2016 May;151(5):R71-8
26884419
J Genet Hum. 1975 Oct;23 SUPPL:42-9
1240123
Cancer Causes Control. 2005 Apr;16(3):295-9
15947881
Hum Mol Genet. 2008 Jul 1;17(13):1922-37
18353795
Cytogenet Genome Res. 2003;103(3-4):217-24
15051942
Biol Reprod. 2004 Apr;70(4):910-8
14645105
Curr Genomics. 2014 Oct;15(5):390-9
25435801
Clin Chem. 2011 Dec;57(12):1722-31
21933900
Environ Pollut. 2016 Jan;208(Pt B):663-9
26552539
J Environ Sci Health A Tox Hazard Subst Environ Eng. 2008 Jun;43(7):675-81
18444068
Cytogenet Cell Genet. 2000;90(3-4):219-26
11124518
J Androl. 2000 Jan-Feb;21(1):33-44
10670517
Reprod Biol Endocrinol. 2013 Jul 16;11:66
23870423
Fertil Steril. 2008 Feb;89(2 Suppl):e59-65
18308066
Environ Res. 2006 Jan;100(1):44-9
16271714
Hum Mol Genet. 2007 Nov 1;16(21):2542-51
17636251
Am J Hum Genet. 2006 Jul;79(1):67-84
16773567
Fertil Steril. 2014 Apr;101(4):1064-71
24524829
Environ Health Perspect. 1996 Aug;104 Suppl 4:699-714
8879999
Endocrinology. 2003 Jul;144(7):3167-75
12810573
Mutat Res. 2011 Sep 1;714(1-2):105-12
21609724
Int J Fertil Steril. 2014 Jul;8(2):113-8
25083174
Hum Reprod. 2015 Apr;30(4):853-60
25740880
Hum Reprod. 2007 Oct;22(10):2639-46
17728352
World J Urol. 1993;11(2):111-9
8343795
Fertil Steril. 2012 Feb;97(2):267-74
22289286
J Androl. 2000 Nov-Dec;21(6):903-12
11105917
Hum Reprod. 2003 May;18(5):1023-8
12721180
Int J Androl. 2008 Apr;31(2):74-80
18194282
Andrologia. 2012 May;44 Suppl 1:187-93
21592178
Clin Epigenetics. 2015 Nov 11;7:120
26566402
Fertil Steril. 2010 Oct;94(5):1728-33
19880108
Mutat Res. 2011 May-Jun;727(3):62-71
21540125
Reprod Toxicol. 2006 Feb;21(2):171-8
16198534
Theriogenology. 2006 Mar 15;65(5):979-91
16242181
Endocrinology. 1997 May;138(5):2081-8
9112408
Reprod Biomed Online. 2007 Jun;14(6):734-45
17579990
Environ Health Perspect. 1997 Nov;105(11):1228-32
9370524
Hum Reprod. 2006 Mar;21(3):685-93
16339168
Endocrinology. 2011 Apr;152(4):1670-83
21325043
Urol Clin North Am. 2014 Feb;41(1):55-66
24286767
Epigenetics. 2011 Jul;6(7):838-42
21637037
Int Arch Occup Environ Health. 2004 Apr;77(3):153-8
14963712
Hum Reprod. 2005 Oct;20(10):2776-83
15980006
Hum Reprod. 2010 Oct;25(10):2647-54
20685756
BMJ. 1996 Feb 24;312(7029):467-71
8597676
BMJ. 1992 Sep 12;305(6854):609-13
1393072
Reprod Biomed Online. 2003 Oct-Nov;7(4):428-32
14656403
J Androl. 2005 Nov-Dec;26(6):654-60
16291955
Biol Reprod. 2008 Oct;79(4):696-703
18633141
Science. 2010 Oct 29;330(6004):622-7
21030646
Fertil Steril. 2009 Apr;91(4):1096-103
18342860
Fertil Steril. 2013 Feb;99(2):327-32
23290686
Environ Health Perspect. 2000 Oct;108(10):961-6
11049816
Arch Androl. 2003 Jan-Feb;49(1):49-55
12647778
Reprod Toxicol. 2011 May;31(4):507-12
21382472
Environ Res. 2014 Jan;128:9-14
24407474
J Endocrinol Invest. 2011 Jun;34(6):e139-43
20959722
Trends Pharmacol Sci. 2011 May;32(5):290-9
21324536
Mutat Res. 2011 Dec 1;717(1-2):38-45
21515291
Chem Res Toxicol. 2000 Jul;13(7):594-600
10898591
J Clin Endocrinol Metab. 1998 Dec;83(12):4177-88
9851748
Front Biosci. 2006 May 01;11:1491-9
16368531
J Androl. 1995 Nov-Dec;16(6):464-8
8867595
Exp Cell Res. 1999 Sep 15;251(2):350-5
10471320
Ann Hum Biol. 2016;43(1):50-6
26211899
N Engl J Med. 1995 Feb 2;332(5):281-5
7816062
Environ Health Perspect. 2015 May;123(5):399-411
25616258
Reprod Biomed Online. 2008 Apr;16(4):523-31
18413061
Rev Reprod. 1999 Jan;4(1):31-7
10051100
Biol Reprod. 2005 Aug;73(2):289-96
15772260
Curr Mol Pharmacol. 2014;7(2):119-35
25620229
Environ Health Perspect. 2009 Feb;117(2):231-40
19270793
Curr Opin Pediatr. 2009 Apr;21(2):243-51
19663042
Reprod Fertil Dev. 2004;16(5):581-8
15367373
Fertil Steril. 1998 Mar;69(3):528-32
9531891
Fertil Steril. 2013 Mar 1;99(3):605-6
23714435
Int J Androl. 2010 Aug 1;33(4):642-9
19878521
Am J Epidemiol. 2009 Sep 1;170(5):559-65
19635736
Hum Reprod. 2011 Sep;26(9):2558-69
21685136
J Hum Reprod Sci. 2013 Jul;6(3):176-82
24347931
Environ Health Perspect. 2000 Sep;108(9):887-94
11017895
Asian J Androl. 2012 Jan;14(1):24-31
22138903
J Androl. 2012 Mar-Apr;33(2):229-38
21546611
Eur J Histochem. 1993;37(2):109-28
7688597
Mutat Res. 2010 Jan 5;683(1-2):9-15
19800896
Fertil Steril. 2014 Jun;101(6):1552-62
24882619
Zygote. 2010 Nov;18(4):357-65
20663262
Andrologia. 2009 Jun;41(3):141-9
19400847
Am J Med Genet C Semin Med Genet. 2004 Feb 15;125C(1):4-11
14755428
Asian J Androl. 2013 Mar;15(2):165-8
23334198
Environ Health Perspect. 2009 Nov;117(11):1745-51
20049127
PLoS One. 2008 Mar 05;3(3):e1738
18320056
Biol Reprod. 2013 Jan 17;88(1):15
23221399
Int J Androl. 2008 Sep;31(5):462-70
18637153
Rev Reprod. 1999 Jan;4(1):38-47
10051101
Hum Reprod. 2016 Jan;31(1):24-33
26628640
Epigenetics. 2012 Sep;7(9):1057-70
22894908
Hum Reprod Update. 2008 May-Jun;14(3):243-58
18281241
Fertil Steril. 1989 Apr;51(4):571-7
2784395
Toxicol Ind Health. 1996 Sep-Oct;12(5):723-35
8989849
Environ Health Perspect. 2010 Jun;118(6):763-8
20061215
Trends Endocrinol Metab. 2010 Apr;21(4):214-22
20074974
Hum Reprod. 2013 May;28(5):1406-17
23315066
Hum Reprod. 2015 May;30(5):1014-28
25753583
Environ Mol Mutagen. 2015 Jan;56(1):50-9
24989325
J Toxicol Environ Health B Crit Rev. 2008 May;11(5-6):373-517
18470797
Asian J Androl. 2006 Jan;8(1):11-29
16372115
Hum Reprod. 2013 Feb;28(2):462-70
23213178
Gene. 2005 Jan 31;345(2):139-53
15716030
Fertil Steril. 2015 Sep;104(3):591-601
26143365
Fertil Steril. 2010 Apr;93(6):1875-9
19217100
Andrologia. 2008 Dec;40(6):346-51
19032683
Hum Reprod. 2003 May;18(5):1055-61
12721184
Exp Cell Res. 2010 Mar 10;316(5):679-87
20083102
Int J Environ Res Public Health. 2015 Jun 16;12 (6):6818-31
26086704
Mol Hum Reprod. 2012 Oct;18(10):489-97
22675043
Hum Reprod. 2007 Jan;22(1):174-9
16921163
Reprod Biomed Online. 2006 Apr;12(4):466-72
16740220
J Assist Reprod Genet. 2012 Mar;29(3):213-23
22290605
Int J Androl. 2011 Aug;34(4 Pt 2):e37-48
21366607
Am J Ind Med. 2000 Sep;38(3):324-9
10940971