Synthesis and characterization of biocompatible antimicrobial N-halamine-functionalized titanium dioxide core-shell nanoparticles.
As one of the most powerful biocides, N-halamine based antimicrobial materials have attracted much interest due to their non-toxicity, rechargeability, and rapid inactivation against a broad range of microorganisms. In this study, novel titanium dioxide-ADMH core-shell nanoparticles [TiO2@poly (ADMH-co-MMA) NPs] were prepared via miniemulsion polymerization using 3-allyl-5,5-dimethylhydantoin (ADMH) and methyl methacrylate (MMA) with nano-TiO2. The produced nanoparticles were characterized by FT-IR, TEM, TGA, and XPS. The UV stability of N-halamine nanoparticles has been improved with the addition of titanium dioxide. After chlorination treatment by sodium hypochlorite, biocidal efficacies of the chlorinated nanoparticles against S. aureus (ATCC 6538) and E. coli O157:H7 (ATCC 43895) were determined. The nanoparticles showed excellent antimicrobial properties against bacteria within brief contact time. In addition, in vitro cell cytocompatibility tests showed that the antibacterial nanoparticles had good biocompatibility.
Key Laboratory of Eco-Textiles of Ministry of Education, Jiangsu Engineering Technology Research Center for Functional Textiles, College of Textiles and Clothing, Jiangnan University, Wuxi, Jiangsu 214122, China.
Lin
L
Li
Key Laboratory of Eco-Textiles of Ministry of Education, Jiangsu Engineering Technology Research Center for Functional Textiles, College of Textiles and Clothing, Jiangnan University, Wuxi, Jiangsu 214122, China.
Wei
W
Ma
Key Laboratory of Eco-Textiles of Ministry of Education, Jiangsu Engineering Technology Research Center for Functional Textiles, College of Textiles and Clothing, Jiangnan University, Wuxi, Jiangsu 214122, China.
Xiaoli
X
Cheng
Key Laboratory of Eco-Textiles of Ministry of Education, Jiangsu Engineering Technology Research Center for Functional Textiles, College of Textiles and Clothing, Jiangnan University, Wuxi, Jiangsu 214122, China. Electronic address: xhren@jiangnan.edu.cn.
Xuehong
X
Ren
Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.
Zhiwei
Z
Xie
College of Life and Environmental Sciences, Shanghai Normal University, Shanghai 200234, China.
Jie
J
Liang
D000588:Amines / Q000737:chemistry*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002700:Chloramines / Q000378:metabolism; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D054879:Halogenation; D006827:Hydantoins / Q000737:chemistry; D020366:Methylmethacrylate / Q000737:chemistry; D051379:Mice; D008826:Microbial Sensitivity Tests; D046529:Microscopy, Electron, Transmission; D041681:NIH 3T3 Cells; D053758:Nanoparticles / Q000737:chemistry* / Q000528:radiation effects / Q000648:ultrastructure; D056951:Photoelectron Spectroscopy; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D013818:Thermogravimetry; D014025:Titanium / Q000737:chemistry*; D014466:Ultraviolet Rays
D000588:Amines; D000900:Anti-Bacterial Agents; D002700:Chloramines; D020099:Coated Materials, Biocompatible; D006827:Hydantoins; C009495:titanium dioxide; D020366:Methylmethacrylate; C030615:5,5-dimethylhydantoin; D014025:Titanium; C030816:chloramine
Antibacterial; N-halamine; Nanoparticles; TiO(2); UV stability