Triterpenoids from Abies faxoniana and their cytotoxic activities.
Two previously unreported triterpenoids (1 and 2) and four known compounds were isolated from Abies faxoniana. Compound 1 has a α,β-unsaturated-γ-lactone ring conjugated with the C-22/23 olefin in the C-17 side chain. The structures of the new compounds were established on the basis of spectroscopic data analysis. These compounds were tested for their cytotoxicities against six human tumour cell lines. Compound 1 showed cytotoxic activities against MCF-7 and A549 cells with IC50values of 7.5 and 8.7 μM, respectively.
b College of Pharmaceutical Sciences , Southwest University , Chongqing , PR China.
Guo-Wei
GW
Wang
a Department of Phytochemistry , Second Military Medical University , Shanghai , PR China.|c Department of Traditional Chinese Medicine , Shanghai Institute of Pharmaceutical Industry , Shanghai , PR China.
Chao
C
Lv
a Department of Phytochemistry , Second Military Medical University , Shanghai , PR China.
Yun-Heng
YH
Shen
a Department of Phytochemistry , Second Military Medical University , Shanghai , PR China.|c Department of Traditional Chinese Medicine , Shanghai Institute of Pharmaceutical Industry , Shanghai , PR China.
Wei-Dong
WD
Zhang
D028202:Abies / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D013057:Spectrum Analysis; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes
Abies faxoniana; Pinaceae; cytotoxicity; lanostane