Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction.
OBJECTIVE
Previous studies revealed the relationship between stable coronary artery disease (CAD) and serum adropin level, but this relationship has not been investigated in patients with non-ST segment elevation myocardial infarction (NSTEMI). The present study is an analysis of the relationship between adropin and severity of CAD assessed based on SYNTAX score in patients with NSTEMI.


METHODS
A total of 109 participants, 80 patients with NSTEMI and 29 healthy individuals, were prospectively enrolled in the study. Patients with NSTEMI were divided to 2 groups: high SYNTAX score (≥32) (35 patients) and low SYNTAX score (<32) (45 patients). Adropin level was measured from blood serum samples using enzyme-linked immunosorbent assay test.


RESULTS
Patients with NSTEMI and high SYNTAX score had significantly lower serum adropin level (2357.30 pg/mL±821.58) compared to NSTEMI patients with low SYNTAX score (3077.00 pg/mL±912.86) and control group (3688.00±956.65). Adropin cut-off value for predicting high SYNTAX score on receiver-operating characteristic curve analysis was determined to be 2759 pg/mL, with a sensitivity of 63% and a specificity of 57%. Adropin was an independent predictor for high SYNTAX score (odds ratio=0.999; 95% confidence interval: 0.998-1.000; p=0.007).


CONCLUSIONS
Adropin could be an alternative blood sample value for predicting severity of CAD.
Department of Cardiology, Turkish High Specialty Training and Research Hospital; Ankara-Turkey. agertem@hotmail.com.
Ahmet Göktuğ
AG
Ertem
Department of Cardiology, Turkish High Specialty Training and Research Hospital; Ankara-Turkey.
Sefa
S
Ünal
Department of Cardiology, Dışkapı Yıldırım Beyazıt Training and Research Hospital; Ankara-Turkey.
Tolga Han
TH
Efe
Department of Cardiology, Turkish High Specialty Training and Research Hospital; Ankara-Turkey.
Burak
B
Açar
Department of Cardiology, Turkish High Specialty Training and Research Hospital; Ankara-Turkey.
Çağrı
Ç
Yayla
Department of Cardiology, Turkish High Specialty Training and Research Hospital; Ankara-Turkey.
Mevlüt Serdar
MS
Kuyumcu
Department of Cardiology, Turkish High Specialty Training and Research Hospital; Ankara-Turkey.
Özgür
Ö
Kırbaş
Department of Cardiology, Tokat State Hospital; Tokat-Turkey.
Cemal
C
Köseoğlu
Department of Cardiology, Turkish High Specialty Training and Research Hospital; Ankara-Turkey.
Mehmet Kadri
MK
Akboğa
Department of Cardiology, Dışkapı Yıldırım Beyazıt Training and Research Hospital; Ankara-Turkey.
Kadriye
K
Gayretli Yayla
Department of Cardiology, Turkish High Specialty Training and Research Hospital; Ankara-Turkey.
Serkan
S
Gökaslan
Department of Cardiology, Turkish High Specialty Training and Research Hospital; Ankara-Turkey.
Sinan
S
Aydoğdu
D015415:Biomarkers / Q000097:blood*; D001798:Blood Proteins; D016022:Case-Control Studies; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000503:physiopathology*; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D000072658:Non-ST Elevated Myocardial Infarction / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D010455:Peptides / Q000097:blood*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D012720:Severity of Illness Index
D015415:Biomarkers; D001798:Blood Proteins; C568440:Enho protein, human; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides
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