Characterization of the Unconventional Secretion of the Ebola Matrix Protein VP40.
While most secreted proteins use the classical endoplasmic reticulum (ER)-Golgi secretion pathway to reach the extracellular medium, a few proteins are secreted through unconventional secretary pathways. Viral proteins can be secreted through unconventional secretion pathways. Here, we describe how we have recently demonstrated that the Ebola virus (EBOV) matrix protein VP40 is released from transfected and infected cells in a soluble form through an unconventional secretion pathway.
Inserm U1111, Université Claude Bernard Lyon 1, International Center for Infectiology Research (CIRI), 21 avenue, Tony Gamler, 69364, USA. olivier.reynard@inserm.fr.
Olivier
O
Reynard
UBIVE, Institut Pasteur, International Center for Infectiology Research (CIRI), Paris, France.
Mathieu
M
Mateo
D016923:Cell Death; D004721:Endoplasmic Reticulum / Q000378:metabolism; D005434:Flow Cytometry; D006056:Golgi Apparatus / Q000378:metabolism; D057809:HEK293 Cells; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D009698:Nucleoproteins / Q000378:metabolism*; D021381:Protein Transport; D055571:Secretory Pathway; D014758:Viral Core Proteins / Q000378:metabolism*
D009698:Nucleoproteins; D014758:Viral Core Proteins; C084819:nucleoprotein VP40, Ebola virus; D007770:L-Lactate Dehydrogenase
Ebola; Ebola virus; Unconventional secretion; VP40; Virus