[The clinical feature and microbiological etiology of patients with infective endocarditis].
Objective:To investigate the clinical features, pathogenic distribution and drug susceptibility of patients with infective endocarditis (IE).Methods:Clinical data of IE patients were collected, who were admitted to Capital Medical University Affiliated Beijing Anzhen Hospital from January 2012 to March 2015.Results:Three hundred and three IE patients were enrolled with age of (43±16) years old. Fever (85.5%)and cardiac murmur (62.4%)were the most common clinical presentations. Congenital heart diseases was the leading underlying diseases in IE patients. Non rheumatic valve diseases (13.5%) followed. Vegetations were found in 90.4%(274/303) patients.Streptococcuswhich accounted for 44.2% was the major pathogen of IE.Staphylococcus(28.9%)was the second common pathogen. Gram-negative bacteria were diversified in categories. Gram-positive cocci were consistently sensitive to vancomycin and linezolid.Conclusions:Congenital heart disease is the main underlying disease related to IE. Streptococcus is still the primary pathogen. Gram-positive cocci keep good sensitivity to vancomycin and linezolid.
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Department of Infectious Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
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Zhu
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004696:Endocarditis / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D005260:Female; D005334:Fever / Q000209:etiology; D006090:Gram-Negative Bacteria / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification*; D006094:Gram-Positive Bacteria / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification*; D006330:Heart Defects, Congenital; D006331:Heart Diseases / Q000453:epidemiology; D006801:Humans; D000069349:Linezolid; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013210:Staphylococcus / Q000187:drug effects / Q000302:isolation & purification; D013291:Streptococcus / Q000187:drug effects / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D000069349:Linezolid