Wolbachia: A biological control strategy against arboviral diseases.
Vector-borne diseases particularly those transmitted by mosquitoes like Dengue are among the leading causes of mortality and morbidity in human population. There are no effective vaccines or treatment against dengue fever till date and the control methods are limited. So, new approaches are urgently in need to reverse these trends. Vector control is currently the primary intervention tool. Strategies that reduce or block pathogen transmission by mosquitoes have been proposed as a means of augmenting current control measures to reduce the growing burden of vector-borne diseases. Wolbachia an endosymbiont of arthropod vectors is being explored as a novel ecofriendly control strategy. Studies in Drosophila have shown that Wolbachia can confer resistance to diverse RNA viruses and protect flies from virus-induced mortality. This review was focused on biology of the Wolbachia and its implication as a control measure for arboviral diseases mainly Dengue and Chikungunya.
Medical Entomology Division, Regional Medical Research Centre (ICMR), Bhubaneswar, Odisha, India.
Ipsita
I
Mohanty
Medical Entomology Division, Regional Medical Research Centre (ICMR); School of Biotechnology, Kalinga Institute of Industrial Technology, Bhubaneswar, Odisha, India.
Animesha
A
Rath
Medical Entomology Division, Regional Medical Research Centre (ICMR), Bhubaneswar, Odisha, India.
Namita
N
Mahapatra
Medical Entomology Division, Regional Medical Research Centre (ICMR), Bhubaneswar, Odisha, India.
Rupenangshu K
RK
Hazra
D000818:Animals; D000898:Antibiosis; D001102:Arbovirus Infections / Q000453:epidemiology / Q000517:prevention & control*; D001103:Arboviruses / Q000254:growth & development*; D009033:Culicidae / Q000382:microbiology*; D018562:Disease Transmission, Infectious / Q000517:prevention & control*; D006801:Humans; D009032:Mosquito Control / Q000379:methods*; D020577:Wolbachia / Q000254:growth & development*