Thrombotic Thrombocytopenic Purpura with Concomitant Progressive Cerebral Microbleeds.
Thrombotic thrombocytopenic purpura (TTP) is a disease caused by excessive platelet thrombi and multisystem vasculopathy. We report a young patient with refractory TTP who has developed multiple multifocal cerebral microbleeds on his brain magnetic resonance imaging scans. TTP-associated thrombotic microangiopathy resulting in diffuse microthrombi formation in the microcirculation and hypoperfusion might be an underlying etiology.
Department of Neurology, University of Tennessee Health Science Center, Memphis, Tennessee.
Nariman
N
Noorbakhsh-Sabet
Department of Neurology, University of Tennessee Health Science Center, Memphis, Tennessee; Department of Neurology, Geisinger Medical Center, Danville, Pennsylvania. Electronic address: ramin.zand@gmail.com.
Ramin
R
Zand
D000328:Adult; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D002560:Cerebrovascular Circulation; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D008833:Microcirculation; D010956:Plasmapheresis; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D000069283:Rituximab / Q000627:therapeutic use
D007155:Immunologic Factors; D000069283:Rituximab
Cerebral microbleeds; MRI; ischemic stroke; thrombotic thrombocytopenic purpura