T-cell subsets in lymph nodes identify a subgroup of follicular lymphoma patients with favorable outcome.
We have analyzed in lymph nodes at diagnosis of 75 patients with follicular lymphoma (FL) the relationship between different T-cell subpopulations, assessed by immunohistochemistry (IHC) and flow cytometry (FC), with the outcome. CD4+cells were the most abundant T-cells in tumor tissue sections, whilst CD57+cells were the less frequent. In addition to nonambulatory performance status, advanced stage and FLIPI, low CD4+CD57+/CD4+ratio (p = .041), and low CD4+/CD8+ratio (p = .008) predicted poor overall survival (OS). Multivariate analysis showed that CD4+CD57+/CD4+ratio was the most important variable for OS. In conclusion, T-cell subpopulations, including CD4+CD57+/CD4+ratio analyzed by FC, could identify FL patients with favorable outcome.
a Department of Hematology , Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) , Barcelona , Spain.
Laura
L
Magnano
b Hematopathology Unit, Department of Pathology , Hospital Clínic, IDIBAPS , Barcelona , Spain.|c Pathology Department, University of Barcelona , Barcelona , Spain.
Antonio
A
Martínez
b Hematopathology Unit, Department of Pathology , Hospital Clínic, IDIBAPS , Barcelona , Spain.|d Department of Pathology , School of Medicine, Tokai University , Isehara , Japan.
Joaquim
J
Carreras
a Department of Hematology , Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) , Barcelona , Spain.
Alejandra
A
Martínez-Trillos
a Department of Hematology , Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) , Barcelona , Spain.
Eva
E
Giné
a Department of Hematology , Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) , Barcelona , Spain.
Jordina
J
Rovira
a Department of Hematology , Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) , Barcelona , Spain.
Ivan
I
Dlouhy
a Department of Hematology , Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) , Barcelona , Spain.
Tycho
T
Baumann
b Hematopathology Unit, Department of Pathology , Hospital Clínic, IDIBAPS , Barcelona , Spain.
Olga
O
Balagué
b Hematopathology Unit, Department of Pathology , Hospital Clínic, IDIBAPS , Barcelona , Spain.|c Pathology Department, University of Barcelona , Barcelona , Spain.
Elías
E
Campo
a Department of Hematology , Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) , Barcelona , Spain.
Armando
A
López-Guillermo
b Hematopathology Unit, Department of Pathology , Hospital Clínic, IDIBAPS , Barcelona , Spain.
Neus
N
Villamor
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015415:Biomarkers; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D008198:Lymph Nodes / Q000473:pathology*; D008224:Lymphoma, Follicular / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D016019:Survival Analysis; D016176:T-Lymphocyte Subsets / Q000378:metabolism*
D015415:Biomarkers
CD4+CD57+ cells; Follicular lymphoma; prognosis