Repletion of vitamin D associated with deterioration of sleep quality among postmenopausal women.
Reduced health-related quality of life (HRQOL), depressive symptoms and poor sleep quality are important health issues among postmenopausal women and may be associated with low vitamin D status. Overweight postmenopausal women, with serum 25-hydroxyvitamin D [25(OH)D] 10-32ng/m, were recruited in Seattle, WA (2010-2012) and randomly assigned to 12months of weight loss +2000IU oral vitamin D3/day or weight loss+daily placebo. The weight-loss program included a reduced-calorie diet and 225min/week of moderate-to-vigorous aerobic activity. Eight subscales of HRQOL were assessed by the MOS 36-Item Short-Form Health Survey. Depressive symptoms were assessed using the Brief Symptom Inventory-18, and sleep quality was assessed using the Pittsburg Sleep Quality Index (PSQI). Mean 12-month changes in HRQOL, depressive symptoms and sleep quality were compared between groups (intent-to-treat) using generalized estimating equations. Compared to placebo, women receiving vitamin D did not experience any significant change in depressive symptoms (p=0.78), HRQOL subscales (all p>0.05), or overall sleep quality (p=0.21). However, a greater magnitude of change in serum 25(OH)D was associated with an increased need to take medications to sleep (ptrend=0.01) and overall worse sleep quality (ptrend<0.01). Women who became vitamin D replete (≥32ng/mL) also showed a deterioration in total PSQI sleep quality score compared to women who remained <32ng/mL despite supplementation, even after adjusting for relevant covariates (Non-Replete: -5.7% vs. Replete: +6.2%, p<0.01). Vitamin D supplementation of 2000IU/d may result in overall worse sleep quality for postmenopausal women with low circulating vitamin D undergoing weight loss.
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
Caitlin
C
Mason
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
Jean
J
de Dieu Tapsoba
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
Catherine
C
Duggan
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, United States; Department of Biostatistics, University of Washington, Seattle, WA, United States.
Ching-Yun
CY
Wang
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, United States; Department of Medicine, University of Washington, Seattle, WA, United States.
Larissa
L
Korde
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, United States; Department of Epidemiology, University of Washington, Seattle, WA, United States. Electronic address: amctiern@fhcrc.org.
Anne
A
McTiernan
D003863:Depression / Q000523:psychology; D005260:Female; D006801:Humans; D017698:Postmenopause / Q000097:blood*; D011788:Quality of Life / Q000523:psychology*; D012893:Sleep Wake Disorders / Q000523:psychology*; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D014861:Washington; D015431:Weight Loss / Q000187:drug effects
25-Hydroxyvitamin D; Caloric restriction; Depression; Exercise; Quality of life; Sleep
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