Sparse activity of identified dentate granule cells during spatial exploration.
In the dentate gyrus - a key component of spatial memory circuits - granule cells (GCs) are known to be morphologically diverse and to display heterogeneous activity profiles during behavior. To resolve structure-function relationships, we juxtacellularly recorded and labeled single GCs in freely moving rats. We found that the vast majority of neurons were silent during exploration. Most active GCs displayed a characteristic spike waveform, fired at low rates and showed spatial activity. Primary dendritic parameters were sufficient for classifying neurons as active or silent with high accuracy. Our data thus support a sparse coding scheme in the dentate gyrus and provide a possible link between structural and functional heterogeneity among the GC population.
Werner-Reichardt Centre for Integrative Neuroscience, University of Tübingen, Tübingen, Germany.|Graduate Training Centre of Neuroscience - IMPRS, University of Tübingen, Tübingen, Germany.
Maria
M
Diamantaki
Werner-Reichardt Centre for Integrative Neuroscience, University of Tübingen, Tübingen, Germany.
Markus
M
Frey
Werner-Reichardt Centre for Integrative Neuroscience, University of Tübingen, Tübingen, Germany.|Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany.|Bernstein Centre for Computational Neuroscience, University of Tübingen, Tübingen, Germany.
Philipp
0000-0002-0199-4727
P
Berens
Werner-Reichardt Centre for Integrative Neuroscience, University of Tübingen, Tübingen, Germany.
Patricia
P
Preston-Ferrer
Werner-Reichardt Centre for Integrative Neuroscience, University of Tübingen, Tübingen, Germany.
Andrea
0000-0003-0039-3599
A
Burgalossi
D000200:Action Potentials; D000818:Animals; D018891:Dentate Gyrus / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D051381:Rats; D065853:Spatial Learning; D065852:Spatial Memory
dentate gyrus; granule cell; juxtacellular; neuroscience; place cell; rat; spatial navigation
J Anat. 1986 Feb;144:31-47
2447048
Neuron. 2014 Feb 5;81(3):653-63
24507196
J Neurosci. 2010 Jun 16;30(24):8296-307
20554881
Nature. 2003 Feb 20;421(6925):844-8
12594513
J Physiol. 2011 Apr 15;589(Pt 8):1905-9
21098002
PLoS Biol. 2008 Jan;6(1):e16
18232737
Nature. 2004 May 13;429(6988):184-7
15107864
Science. 2014 Feb 21;343(6173):891-6
24457213
J Stat Softw. 2010;33(1):1-22
20808728
J Neurosci. 2006 Jan 4;26(1):3-11
16399667
Curr Biol. 2016 Feb 22;26(4):536-41
26853363
Trends Neurosci. 2015 Jul;38(7):417-27
26093844
Nature. 2008 Jan 3;451(7174):65-8
18094684
Brain Res. 1977 Mar 25;124(2):225-36
843945
Epilepsia. 2012 Jun;53 Suppl 1:109-15
22612815
Nat Rev Neurosci. 2014 Apr;15(4):264-78
24569488
Neuron. 2010 Sep 23;67(6):1048-61
20869600
J Comp Neurol. 1997 Jan 6;377(1):15-28
8986869
Trends Neurosci. 2012 Jun;35(6):345-55
22579264
Hippocampus. 1993 Apr;3(2):165-82
8353604
Science. 2007 Feb 16;315(5814):961-6
17303747
Neuron. 2014 Apr 2;82(1):71-8
24613417
Nat Methods. 2012 Jul;9(7):671-5
22930834
Curr Opin Neurobiol. 2010 Jun;20(3):306-12
20400290
Curr Opin Neurobiol. 2004 Aug;14(4):481-7
15321069
Hippocampus. 1996;6(2):149-72
8797016
Dev Neurosci. 2007;29(1-2):14-27
17148946
Neuron. 2011 Mar 24;69(6):1160-75
21435560
J Neurosci. 2011 Sep 21;31(38):13469-84
21940440
J Neurosci Methods. 1996 Apr;65(2):113-36
8740589
Neuron. 2016 Apr 6;90(1):101-12
26971949
Brain Res. 2004 Aug 13;1017(1-2):21-31
15261095
J Electron Microsc Tech. 1989 Jun;12(2):80-7
2760687
Nature. 2008 Jan 3;451(7174):61-4
18094685
Cell Rep. 2013 Sep 12;4(5):1010-21
23994479
Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):15049-54
19706480
Hippocampus. 2008;18(4):364-75
18189310
Science. 2009 May 1;324(5927):643-6
19407203
PLoS One. 2012;7(6):e38971
22701737
J Neurophysiol. 2012 Jul;108(2):697-707
22514297
Hippocampus. 2009 Apr;19(4):321-37
18958849
Neuron. 2014 Jan 8;81(1):140-52
24333053
J Neurosci. 2016 Feb 17;36(7):2289-301
26888938
Hippocampus. 1994 Jun;4(3):374-91
7842058
J Neurosci. 2012 Mar 14;32(11):3848-58
22423105
Hippocampus. 2010 Oct;20(10):1109-23
20872737
Neuroscience. 1992 Aug;49(4):793-805
1279455
J Comp Neurol. 2001 Jul 9;435(4):406-17
11406822
Nat Protoc. 2014 Oct;9(10):2369-81
25211514
Nat Biotechnol. 2016 Feb;34(2):199-203
26689543
Neuron. 2014 Dec 17;84(6):1191-7
25482025
J Neurosci. 2015 Sep 9;35(36):12346-54
26354904
Neuron. 2011 Apr 14;70(1):109-20
21482360
Neuron. 2014 Jan 22;81(2):416-27
24462102
Front Neural Circuits. 2014 Jul 11;8:74
25071455
Nature. 2004 Feb 19;427(6976):704-10
14973477
Neuron. 2011 May 26;70(4):773-86
21609831
Neurosci Lett. 1985 Mar 15;54(2-3):219-24
3991060
Exp Neurol. 2011 Jun;229(2):332-8
21376037
J Neurosci. 2005 Nov 2;25(44):10074-86
16267214