Therapeutic Potential and Molecular Targets of Piceatannol in Chronic Diseases.
Piceatannol (3,3',4,5'-tetrahydroxy-trans-stilbene; PIC) is a naturally occurring stilbene present in diverse plant sources. PIC is a hydroxylated analog of resveratrol and produced from resveratrol by microsomal cytochrome P450 1A11/2 and 1B1 activities. Like resveratrol, PIC has a broad spectrum of health beneficial effects, many of which are attributable to its antioxidative and anti-inflammatory activities. PIC exerts anticarcinogenic effects by targeting specific proteins involved in regulating cancer cell proliferation, survival/death, invasion, metastasis, angiogenesis, etc. in tumor microenvironment. PIC also has other health promoting and disease preventing functions, such as anti-obese, antidiabetic, neuroptotective, cardioprotective, anti-allergic, anti-aging properties. This review outlines the principal biological activities of PIC and underlying mechanisms with special focus on intracellular signaling molecules/pathways involved.
Department of Molecular Medicine and Biopharmaceutical Sciences, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151-742, South Korea. surh@snu.ac.kr.
Young-Joon
YJ
Surh
Department of Food and Nutrition, College of Human Ecology, Sungshin Women's University, Seoul, 142-732, South Korea. nhkdec28@gmail.com.
Hye-Kyung
HK
Na
D000375:Aging / Q000187:drug effects; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D002908:Chronic Disease; D006801:Humans; D058990:Molecular Targeted Therapy; D018696:Neuroprotective Agents / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects; D013267:Stilbenes / Q000494:pharmacology / Q000627:therapeutic use*
D016588:Anticarcinogenic Agents; D018696:Neuroprotective Agents; D013267:Stilbenes; C041525:3,3',4,5'-tetrahydroxystilbene
Astringin; Piceatannol; Resveratrol; trans-Stilbene