Carbopalladation Cascades Using Carbon-Carbon Triple Bonds: Recent Advances to Access Complex Scaffolds.
Alkynes are one of the most versatile functional groups as synthetic handles. They allow for a direct access to partially or fully substituted alkenes through difunctionalization reactions. A prominently utilized transformation for these sequences is the carbopalladation of alkynes, which can be followed by various termination steps such as aromatizations, dearomatizations, cross-coupling reactions, or pericyclic processes, amongst others. This Minireview provides an overview of the recent literature published in the field of carbopalladation chemistry, both with a focus on methodology as well as its application in the syntheses of complex molecular scaffolds, natural products, and functional molecules.
BASF SE, Carl-Bosch-Str. 38, 67056, Ludwigshafen, Germany.
Alexander
A
Düfert
Technische Universität Braunschweig, Institut für Organische Chemie, Hagenring 30, 38106, Braunschweig, Germany.
Daniel B
DB
Werz
Heck reactions; carbopalladation; cascades; cross-coupling reactions; domino reactions