Protein Phosphatases Involved in Regulating Mitosis: Facts and Hypotheses.
Almost all eukaryotic proteins are subject to post-translational modifications during mitosis and cell cycle, and in particular, reversible phosphorylation being a key event. The recent use of high-throughput experimental analyses has revealed that more than 70% of all eukaryotic proteins are regulated by phosphorylation; however, the mechanism of dephosphorylation, counteracting phosphorylation, is relatively unknown. Recent discoveries have shown that many of the protein phosphatases are involved in the temporal and spatial control of mitotic events, such as mitotic entry, mitotic spindle assembly, chromosome architecture changes and cohesion, and mitotic exit. This implies that certain phosphatases are tightly regulated for timely dephosphorylation of key mitotic phosphoproteins and are essential for control of various mitotic processes. This review describes the physiological and pathological roles of mitotic phosphatases, as well as the versatile role of various protein phosphatases in several mitotic events.
Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon 16419, Korea.
Hyun-Soo
HS
Kim
Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon 16419, Korea.
Gary
G
Fernandes
Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon 16419, Korea.|Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul 06351, Korea.
Chang-Woo
CW
Lee
D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D006801:Humans; D008938:Mitosis / Q000502:physiology*; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*; D010766:Phosphorylation
D010749:Phosphoprotein Phosphatases
chromosome; human disease; kinase; mitosis; protein phosphatase; therapeutics
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