The positive effects of high-frequency right dorsolateral prefrontal cortex repetitive transcranial magnetic stimulation on memory, correlated with increases in brain metabolites detected by proton magnetic resonance spectroscopy in recently detoxified alcohol-dependent patients.
OBJECTIVE
To explore the effect of right dorsolateral prefrontal cortex (DLPFC) repetitive transcranial magnetic stimulation (rTMS) on memory, and its correlation with levels of hippocampal brain metabolites detected by proton magnetic resonance spectroscopy (1H-MRS) in recently detoxified alcohol-dependent patients.


METHODS
In this randomized, double-blind sham-controlled trial, alcohol-dependent patients were enrolled and randomized into two groups: the experimental group (rTMS, 10 Hz, on right DLPFC, 20 sessions) and the control group (sham stimulation). Memory function was assessed using Hopkins Verbal Learning Test-Revised (HVLT-R) and Brief Visuospatial Memory Test-Revised (BVMT-R) before and after treatment.1H-MRS was used to detect the levels ofN-acetyl aspartic acid (NAA), choline (Cho), and creatine (Cr) in bilateral hippocampi before and after treatment.


RESULTS
Thirty-eight patients (18 in the experimental group and 20 in the control group) were included in the analyses. The experimental group showed significantly greater changes in HVLT-R, BVMT-R, NAA/Cr, and Cho/Cr after rTMS from baseline than the control group. The percentage change in BVMT-R and HVLT-R correlated with the percentage change in NAA/Cr and Cho/Cr in the right brain.


CONCLUSIONS
High-frequency right DLPFC rTMS was associated with improvement in memory dysfunction, which is correlated with levels of hippocampal brain metabolites detected by1H-MRS in recently detoxified alcohol-dependent patients.
Institute of Mental Health, The First Hospital of Hebei Medical University; Brain Ageing and Cognitive Neuroscience Laboratory, Hebei Medical University.
Jun
J
Qiao
Institute of Mental Health, The First Hospital of Hebei Medical University; Brain Ageing and Cognitive Neuroscience Laboratory, Hebei Medical University.
Guixing
G
Jin
Department of Radiology, The First Hospital of Hebei Medical University, Hebei, People's Republic of China.
Licun
L
Lei
Institute of Mental Health, The First Hospital of Hebei Medical University; Brain Ageing and Cognitive Neuroscience Laboratory, Hebei Medical University.
Lan
L
Wang
Department of Radiology, The First Hospital of Hebei Medical University, Hebei, People's Republic of China.
Yaqiang
Y
Du
Institute of Mental Health, The First Hospital of Hebei Medical University; Brain Ageing and Cognitive Neuroscience Laboratory, Hebei Medical University.
Xueyi
X
Wang
MR spectroscopy; alcohol dependence; memory; repetitive transcranial magnetic stimulation
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