[STAT3 and NF-κB is activated in papillary thyroid carcinoma tissues].
Objective To explore the relationship between signal transducers and activators of transcription 3 (STAT3) and nuclear factor κB (NF-κB) signaling pathway in papillary thyroid carcinoma. Methods The study enrolled 69 patients with thyroid cancer and 58 control individuals. Real-time fluorescence quantitative PCR, ELISA and immunohistochemistry were separately used to detect mRNA and protein expressions of NF-κB and STAT3 in normal thyroid and thyroid carcinoma tissues. Results Compared with normal thyroid tissues, both mRNA and protein expressions of NF-κB and STAT3 increased significantly in thyroid carcinoma tissues. Immunohistochemistry showed that the positive rate of STAT3 in all patients with thyroid cancer (89.3%) was significantly higher than that in the patients with normal thyroid tissue (10.2%). Conclusion The function of NF-κB pathway mediated by STAT3 is activated in patients with thyroid cancer.
Department of Otorhinolaryngology, First Affiliated Hospital of Xi'an Medical University, Xi'an 710077, China.
Fei
F
Wang
Department of Otorhinolaryngology, Yihe Hospital, Zhengzhou 450000, China.
Dahu
D
Luo
Department of Ophthalmology & Otorhinolaryngology, Shaanxi Normal University Hospital, Xi'an 710069, China. *Corresponding author, E-mail: 987759459@qq.com.
Xuemei
X
Liu
D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000235:genetics / Q000378:metabolism*; D002291:Carcinoma, Papillary; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*; D050796:STAT3 Transcription Factor / Q000235:genetics / Q000378:metabolism*; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000235:genetics / Q000378:metabolism*
D016328:NF-kappa B; D050796:STAT3 Transcription Factor