Lower serum uric acid is associated with mild cognitive impairment in early Parkinson's disease: a 4-year follow-up study.
Cognitive deficits are common in Parkinson's disease (PD) and many patients eventually develop dementia; however, its occurrence is unpredictable. Serum uric acid (UA) has been proposed as a biomarker of PD, both in the preclinical and clinical phase of the disease. The aim of this pilot study was to evaluate relationships between baseline serum UA levels and occurrence of mild cognitive impairment (MCI) at 4-year follow-up in a cohort of early PD patients. Early PD patients, not presenting concomitant diseases, cognitive impairment or treatment possibly interfering with UA levels, underwent neuropsychological testing at baseline and 4-year follow-up. UA levels were determined in serum at baseline. MCI was found in 23 out of 42 PD patients completing 4-year follow-up. Patients presenting MCI had significantly higher age at onset and lower Frontal Assessment Battery scores at baseline as compared with patients cognitively intact. Logistic regression analysis showed that both serum UA levels (OR = 0.54, p = 0.044) and age (OR = 1.16, p = 0.009) contribute to the occurrence of MCI at 4-year follow-up. Our pilot study suggests that lower levels of serum UA in the early disease stages are associated to the later occurrence of MCI. These results need to be confirmed by further studies on larger samples.
Neuroscience Section, Department of Medicine and Surgery, Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Salerno, Italy. mpellecchia@unisa.it.
Maria Teresa
MT
Pellecchia
AOU San Giovanni di Dio e Ruggi d'Aragona, Salerno, Italy.
Riccardo
R
Savastano
Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II University, Naples, Italy.
Marcello
M
Moccia
Neuroscience Section, Department of Medicine and Surgery, Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Salerno, Italy.
Marina
M
Picillo
AOU San Giovanni di Dio e Ruggi d'Aragona, Salerno, Italy.
Pietro
P
Siano
Department of Neurological and Movement Sciences, University of Verona, Verona, Italy.
Roberto
R
Erro
Neuroscience Section, Department of Medicine and Surgery, Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Salerno, Italy.
Annamaria
A
Vallelunga
IDC Hermitage-Capodimonte, Naples, Italy.
Marianna
M
Amboni
IDC Hermitage-Capodimonte, Naples, Italy.|University of Naples Parthenope, Naples, Italy.
Carmine
C
Vitale
IDC Hermitage-Capodimonte, Naples, Italy.|Neuropsychology Laboratory, Department of Psychology, Second University of Naples, Caserta, Italy.
Gabriella
G
Santangelo
Neuroscience Section, Department of Medicine and Surgery, Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Salerno, Italy.
Paolo
P
Barone
D000368:Aged; D060825:Cognitive Dysfunction / Q000097:blood* / Q000000981:diagnostic imaging / Q000209:etiology*; D005260:Female; D006801:Humans; D007558:Italy; D016015:Logistic Models; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D014527:Uric Acid / Q000378:metabolism*
D014527:Uric Acid
Biomarker; Early Parkinson’s disease; Mild cognitive impairment; Uric acid
Mov Disord. 2010 May 15;25(7):932-6
20310031
Brain. 2007 Jul;130(Pt 7):1787-98
17535834
Age (Dordr). 2016 Feb;38(1):16
26820749
Neurology. 2010 Sep 21;75(12):1062-9
20855849
J Gerontol A Biol Sci Med Sci. 2002 Oct;57(10):M660-4
12242321
Parkinsonism Relat Disord. 2014 Jun;20(6):637-9
24637121
Arch Neurol. 2008 Jun;65(6):716-23
18413464
Brain. 2009 Feb;132(Pt 2):377-82
19036766
Mov Disord. 2012 Mar;27(3):349-56
22275317
J Neural Transm (Vienna). 2016 Apr;123(4):371-7
26739446
Parkinsonism Relat Disord. 2011 Jun;17(5):333-7
21320793
Eur J Neurol. 2015 Jan;22(1):93-8
25104282
Mov Disord. 2008 Sep 15;23(12):1653-7
18618666
JAMA Neurol. 2014 Feb;71(2):141-50
24366103