Bisboronic Acids for Selective, Physiologically Relevant Direct Glucose Sensing with Surface-Enhanced Raman Spectroscopy.
This paper demonstrates the direct sensing of glucose at physiologically relevant concentrations with surface-enhanced Raman spectroscopy (SERS) on gold film-over-nanosphere (AuFON) substrates functionalized with bisboronic acid receptors. The combination of selectivity in the bisboronic acid receptor and spectral resolution in the SERS data allow the sensors to resolve glucose in high backgrounds of fructose and, in combination with multivariate statistical analysis, detect glucose accurately in the 1-10 mM range. Computational modeling supports assignments of the normal modes and vibrational frequencies for the monoboronic acid base of our bisboronic acids, glucose and fructose. These results are promising for the use of bisboronic acids as receptors in SERS-based in vivo glucose monitoring sensors.
Department of Chemistry, Northwestern University , 2145 Sheridan Rd., Evanston, Illinois 60208, United States.|Department of Chemistry, University of Tennessee , 1420 Circle Dr., Knoxville, Tennessee 37931, United States.
Bhavya
B
Sharma
Department of Chemistry, Northwestern University , 2145 Sheridan Rd., Evanston, Illinois 60208, United States.
Pradeep
P
Bugga
Department of Chemistry, Northwestern University , 2145 Sheridan Rd., Evanston, Illinois 60208, United States.
Lindsey R
LR
Madison
Department of Chemistry, Northwestern University , 2145 Sheridan Rd., Evanston, Illinois 60208, United States.
Anne-Isabelle
AI
Henry
Department of Chemistry, Northwestern University , 2145 Sheridan Rd., Evanston, Illinois 60208, United States.
Martin G
MG
Blaber
Department of Chemistry, Northwestern University , 2145 Sheridan Rd., Evanston, Illinois 60208, United States.
Nathan G
NG
Greeneltch
Department of Chemistry, Northwestern University , 2145 Sheridan Rd., Evanston, Illinois 60208, United States.
Naihao
N
Chiang
Department of Chemistry, Northwestern University , 2145 Sheridan Rd., Evanston, Illinois 60208, United States.
Milan
M
Mrksich
Department of Chemistry, Northwestern University , 2145 Sheridan Rd., Evanston, Illinois 60208, United States.
George C
GC
Schatz
Department of Chemistry, Northwestern University , 2145 Sheridan Rd., Evanston, Illinois 60208, United States.
Richard P
RP
Van Duyne