Gastrointestinal Side Effects of Post-Transplant Therapy.
Modern immunosuppressive therapy has produced a real revolution in renal and organ transplantation but it comes with the price of multiple side effects. There are many gastrointestinal (GI) complications that are the consequence of transplant immunosuppressant medication. In fact, for any immunosuppressant therapy, certain standardized precepts and attitudes that aim to reduce the incidence and the impact of the medication side effects must be applied. Many patients undergo renal transplantation and the physicians have to be aware of the advantages and the risks associated. This article reviews the main GI complications that may arise as a consequence of immunosuppressive therapy after solid organ transplantation, focusing on renal and renal/pancreas transplantation, as well as the ways in which the incidence of these complications can be reduced. Management of the post-transplant therapy is mandatory in order to increase not only the grafts' and the patients' survival, but also their quality of life by the occurrence of fewer complications.
Department of Renal Transplantation, Clinical Institute of Urology and Renal Transplantation, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. lucan_valerian@yahoo.com.
Valerian Ciprian
VC
Lucan
General Surgery and Kidney Transplantation Unit, Policlinico University Hospital IRCCS, Milan, Italy.
Luisa
L
Berardinelli
D005767:Gastrointestinal Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control*; D006085:Graft Survival / Q000187:drug effects*; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation / Q000009:adverse effects*; D009894:Opportunistic Infections / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology; D016035:Pancreas Transplantation / Q000009:adverse effects*; D011379:Prognosis; D012307:Risk Factors; D016896:Treatment Outcome
D007166:Immunosuppressive Agents