Structural Imaging Changes and Behavioral Correlates in Patients with Crohn's Disease in Remission.
Background:Crohn's disease (CD) is a subtype of inflammatory bowel disease caused by immune-mediated inflammation in the gastrointestinal tract. The extent of morphologic brain alterations and their associated cognitive and affective impairments remain poorly characterized.Aims: We used magnetic resonance imaging to identify structural brain differences between patients with Crohn's disease in remission compared to age-matched healthy controls and evaluated for structural-behavioral correlates.Methods:Nineteen patients and 20 healthy, age-matched controls were recruited in the study. Group differences in brain morphometric measures and correlations between brain measures and performance on a cognitive task, the verbal fluency (VF) task, were examined. Correlations between brain measures and cognitive measures as well as self-reported measures of depression, personality, and affective scales were examined.Results: Patients showed significant cortical thickening in the left superior frontal region compared to controls. Significant group differences were observed in sub-cortical volume measures in both hemispheres. Investigation of brain-behavior correlations revealed significant group differences in the correlation between cortical surface area and VF performance, although behavioral performance was equivalent between the two groups. The left middle temporal surface area was a significant predictor of VF performance with controls showing a significant positive correlation between these measures, and patients showing the opposite effect.Conclusion: Our results indicate key differences in structural brain measures in patients with CD compared to controls. Additionally, correlation between brain measures and behavioral responses suggest there may be a neural basis to the alterations in patients' cognitive and affective responses.
Department of Radiology, School of Medicine and Public Health, University of Wisconsin - Madison, Madison WI, USA.
Veena A
VA
Nair
Division of Gastroenterology and Hepatology, University of Wisconsin - Madison, Madison WI, USA.
Poonam
P
Beniwal-Patel
Department of Radiology, School of Medicine and Public Health, University of Wisconsin - Madison, MadisonWI, USA; Division of Gastroenterology and Hepatology, University of Wisconsin - Madison, MadisonWI, USA.
Ifeanyi
I
Mbah
Department of Radiology, School of Medicine and Public Health, University of Wisconsin - Madison, MadisonWI, USA; Medical Scientist Training Program, University of Wisconsin - Madison, MadisonWI, USA; Neuroscience Training Program, University of Wisconsin - Madison, MadisonWI, USA.
Brittany M
BM
Young
Department of Radiology, School of Medicine and Public Health, University of Wisconsin - Madison, MadisonWI, USA; Medical Scientist Training Program, University of Wisconsin - Madison, MadisonWI, USA; Neuroscience Training Program, University of Wisconsin - Madison, MadisonWI, USA; Department of Neurology, University of Wisconsin - Madison, MadisonWI, USA; Department of Psychology and Department of Psychiatry, University of Wisconsin - Madison, MadisonWI, USA.
Vivek
V
Prabhakaran
Division of Gastroenterology and Hepatology, University of Wisconsin - Madison, Madison WI, USA.
Sumona
S
Saha
Crohn’s disease; cortical thickness; gut-brain axis; neuroimaging
Restor Neurol Neurosci. 2009;27(5):391-403
19847066
Arthritis Rheum. 2012 Feb;64(2):371-9
21905009
Ann Neurol. 1987 Jun;21(6):530-9
3606042
Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17089-94
24082094
Clin Gastroenterol Hepatol. 2012 Apr;10 (4):434-8.e1
22155560
Acad Emerg Med. 2001 Dec;8(12):1153-7
11733293
Neurology. 2008 Jan 8;70(2):153-4
17959767
Psychol Assess. 2010 Mar;22(1):43-9
20230150
Ann Neurol. 2014 Nov;76(5):660-8
25087843
J Pers Assess. 1995 Jun;64(3):507-21
7760258
Nat Rev Neurosci. 2013 Jul;14(7):502-11
23719569
Brain Lang. 2010 Dec;115(3):149-61
20728207
Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5669-74
11960021
Gut. 2006 Jun;55(6):749-53
16698746
J Clin Psychol. 1997 Aug;53(5):517-21
9257231
Stroke. 2006 Aug;37(8):2134-9
16809554
Gastroenterology. 2010 Jul;139(1):48-57.e2
20347816
J Clin Psychiatry. 2001;62 Suppl 8:38-45; discussion 46-7
12108820
Trends Neurosci. 2009 May;32(5):291-301
19380167
J Pain. 2015 Dec;16(12):1366-76
26431880
Neuroimage. 2004 Jul;22(3):1060-75
15219578
Gastroenterology. 2015 Oct;149(4):864-6
26264347
Ann Emerg Med. 2001 Dec;38(6):633-8
11719741
Int J Epidemiol. 2010 Oct;39(5):1362-9
20504860
J Neurosci. 2007 Apr 11;27(15):4004-7
17428976
Am J Emerg Med. 2002 Jul;20(4):287-90
12098173
Eur J Pain. 2016 Apr;20(4):512-20
26223337
J Pers Soc Psychol. 1988 Jun;54(6):1020-30
3397861
Pain. 2002 Sep;99(1-2):313-21
12237210
IEEE Trans Med Imaging. 2001 Jan;20(1):70-80
11293693
J Comp Neurol. 1997 Oct 20;387(2):167-78
9336221
Neurology. 2005 Nov 8;65(9):1483-6
16275843
J Crohns Colitis. 2015 Jul;9(7):532-40
25895879
Nat Neurosci. 2003 Mar;6(3):309-15
12548289
Neurosci Lett. 2007 May 18;418(3):227-31
17466454
J Clin Exp Neuropsychol. 2004 Oct;26(7):874-90
15742539
Arch Clin Neuropsychol. 1996;11(4):329-38
14588937
Nat Neurosci. 2001 Nov;4 Suppl:1199-206
11687830
J Abnorm Psychol. 1988 Aug;97(3):346-53
3192830
Pain. 2008 Jul;137(1):7-15
18410991
Nat Rev Neurosci. 2006 Apr;7(4):268-77
16552413
PLoS One. 2015 Feb 13;10(2):e0116687
25679805
Gastroenterology. 2010 May;138(5):1783-9
20045701
J Neurosci. 2011 May 11;31(19):7174-7
21562281
J Epidemiol Community Health. 2007 Mar;61(3):241-7
17325403
J Neurosci. 2007 Apr 25;27(17):4603-11
17460073
Neuroimage. 2009 Nov 1;48(2):371-80
19559801
J Neurosci. 2009 Nov 4;29(44):13746-50
19889986
Lancet. 1974 Nov 9;2(7889):1127-31
4139420
Nat Rev Neurosci. 2009 Jan;10 (1):59-70
19096369
Neuroimage. 2014 Feb 15;87:120-6
24246495
Anesth Analg. 2007 May;104(5):1223-9, tables of contents
17456678
Neuroimage. 2010 Nov 15;53(3):1135-46
20006715
Clin Gastroenterol Hepatol. 2006 Dec;4(12):1491-1501
17162241
Brain Lang. 1997 May;57(3):394-405
9126423
Arch Gen Psychiatry. 1994 Jun;51(6):477-84
8192550
Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11050-5
10984517
Brain. 2007 Jul;130(Pt 7):1718-31
17392317
Nat Neurosci. 2000 May;3(5):509-15
10769393
J Pers Soc Psychol. 1988 Jun;54(6):1063-70
3397865
Cereb Cortex. 2004 Jan;14(1):11-22
14654453
Annu Rev Med. 2011;62:381-96
21090962