Urinary sediment suggests lupus nephritis histology.
Objectives The objective of this paper was to evaluate correlations between kidney biopsy indexes (activity and chronicity) and urinary sediment findings; the secondary objective was to find which components of urinary sediment can discriminate proliferative from other classes of lupus nephritis. Methods Lupus nephritis patients scheduled for a kidney biopsy were included in our study. The morning before the kidney biopsy, we took urine samples from each patient. Receiver operating characteristic (ROC) curves were plotted to determine the area under the curve (AUC) of each test for detecting proliferative lupus nephritis; a classification tree was calculated to select a set of values that best-predicted lupus nephritis classes. Results We included 51 patients, 36 of whom were women (70.6%). Correlations of lupus nephritis activity index with the counts in the urinary sediment of erythrocytes (isomorphic and dysmorphic), acanthocytes, and leukocytes were 0.65 ( p < 0.0001) 0.62 ( p < 0.0001) and 0.22 ( p = 0.1228), respectively. Correlations of lupus nephritis chronicity index with the counts of erythrocytes, acanthocytes, and leukocytes were 0.60 ( p ≤ 0.0001), 0.52 ( p = 0.0001) and 0.17 ( p = 0.2300), respectively. Our classification tree had an accuracy of 84.3%. Conclusions Evaluation of urine sediment reflects lupus nephritis histology.
1 Hospital General de Zona No 1, Instituto Mexicano del Seguro Social.|2 Department of Rheumatology, Hospital Central "Dr. Ignacio Morones Prieto," San Luis Potosí, S.L.P., México.|3 Faculty of Medicine, Universidad Autónoma de San Luis Potosí, San Luis Potosí, S.L.P., México.
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Martínez-Martínez
3 Faculty of Medicine, Universidad Autónoma de San Luis Potosí, San Luis Potosí, S.L.P., México.
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Llamazares-Azuara
4 Department of Pathology, Hospital Central "Dr. Ignacio Morones Prieto," San Luis Potosí, S.L.P., México.
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Martínez-Galla
3 Faculty of Medicine, Universidad Autónoma de San Luis Potosí, San Luis Potosí, S.L.P., México.
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Mandeville
3 Faculty of Medicine, Universidad Autónoma de San Luis Potosí, San Luis Potosí, S.L.P., México.
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Valadez-Castillo
5 Department of Nephrology, Hospital Central "Dr. Ignacio Morones Prieto," San Luis Potosí, S.L.P., México.
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Román-Acosta
5 Department of Nephrology, Hospital Central "Dr. Ignacio Morones Prieto," San Luis Potosí, S.L.P., México.
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Borjas-García
2 Department of Rheumatology, Hospital Central "Dr. Ignacio Morones Prieto," San Luis Potosí, S.L.P., México.|3 Faculty of Medicine, Universidad Autónoma de San Luis Potosí, San Luis Potosí, S.L.P., México.
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Abud-Mendoza
D000293:Adolescent; D000328:Adult; D019540:Area Under Curve; D001706:Biopsy; D005260:Female; D006801:Humans; D008181:Lupus Nephritis / Q000473:pathology* / Q000652:urine; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012720:Severity of Illness Index; D014556:Urine / Q000737:chemistry*; D055815:Young Adult
Systemic lupus erythematosus; biomarkers; kidney biopsy; lupus nephritis