Efficacy of adjunctive mitomycin C in transcanalicular diode laser dacryocystorhinostomy.
The objective of the study was to compare the success rate of transcanalicular laser dacryocystorhinostomy (TCL-DCR) with or without the use of adjunctive mitomycin C (MMC) in cases with primary nasolacrimal duct obstruction (NLDO). This retrospective study was comprised of 68 patients with uncomplicated primary NLDO. There were two groups in the study: the Group 1 (n = 35) patients underwent TCL-DCR surgery with MMC and the Group 2 (n = 33) patients underwent TCL-DCR surgery without MMC. All patients had bicanalicular silicone tube intubation. The main outcome measures were patent osteotomy as visualized endoscopically and patent nasolacrimal irrigation. The follow-up period was 12 months. All patients had unilateral TCL-DCR with silicone tube intubation. Six months following surgery, the silicone tubes were removed. At the final evaluation, success rates were 80 % in Group 1 and 78.8 % in Group 2. There was no statistically significant difference between the two groups (p = 0.52). No complications related to MMC usage were recorded during the study period. Intraoperative use of MMC has no beneficial effect on the success rate in TCL-DCR.
Department of Ophthalmology, School of Medicine, Istanbul Medipol University, Bagcilar, 34214, Istanbul, Turkey.
Mustafa
M
Ozsutcu
Department of Ophthalmology, School of Medicine, Istanbul Medipol University, Bagcilar, 34214, Istanbul, Turkey. ozlembmd@yahoo.com.
Ozlem
O
Balci
Department of Ophthalmology, School of Medicine, Istanbul Medipol University, Bagcilar, 34214, Istanbul, Turkey.
Cafer
C
Tanriverdi
Department of Ophthalmology, School of Medicine, Istanbul Medipol University, Bagcilar, 34214, Istanbul, Turkey.
Goktug
G
Demirci
D000328:Adult; D017024:Chemotherapy, Adjuvant; D003608:Dacryocystorhinostomy / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007767:Lacrimal Duct Obstruction / Q000188:drug therapy*; D054023:Lasers, Semiconductor / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D019384:Nucleic Acid Synthesis Inhibitors / Q000627:therapeutic use*; D012189:Retrospective Studies; D016896:Treatment Outcome
D019384:Nucleic Acid Synthesis Inhibitors; D016685:Mitomycin
Mitomycin C; Nasolacrimal duct obstruction; Transcanalicular laser dacryocystorhinostomy
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