Chemical constituents and antitumor activity from Paris polyphylla Smith var. yunnanensis.
Eleven compounds were isolated from the rhizomes of Paris polyphylla Smith var. yunnanensis. Their structures were elucidated on the basis of rigorous 1D and 2D NMR experiments as well as comparison with the literature data. To the best of our knowledge, compound 1 was only predicted by UPLC/Q-TOF MSEand the NMR spectroscopic data was given for the first time. The cytotoxic activities of all compounds on mouse B16 cells were evaluated. Among the tested molecules, compounds 6-9 showed strong cytotoxicities, while compound 1 did not show significant effect.
a Tianjin Key Laboratory for Modern Drag Delivery & High Efficiency, School of Pharmaceutical Science and Technology , Tianjin University , Tianjin , P.R. China.
Songsong
S
Jing
b Tianjin Key Laboratory of Chemistry and Analysis of Chinese Materia Medic , Tianjin University of Traditional Chinese Medicine , Tianjin , P.R. China.
Ying
Y
Wang
a Tianjin Key Laboratory for Modern Drag Delivery & High Efficiency, School of Pharmaceutical Science and Technology , Tianjin University , Tianjin , P.R. China.
Xia
X
Li
c Tianjin Key Laboratory of Industry Microbiology, College of Biotechnology , Tianjin University of Science & Technology , Tianjin , P.R. China.
Shuli
S
Man
a Tianjin Key Laboratory for Modern Drag Delivery & High Efficiency, School of Pharmaceutical Science and Technology , Tianjin University , Tianjin , P.R. China.
Wenyuan
W
Gao
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D008401:Gas Chromatography-Mass Spectrometry; D019668:Liliaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D008968:Molecular Conformation; D027343:Rhizome / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013329:Structure-Activity Relationship; D013778:Tetrazolium Salts; D013844:Thiazoles
D000972:Antineoplastic Agents, Phytogenic; D013778:Tetrazolium Salts; D013844:Thiazoles; C022616:thiazolyl blue
Liliaceae; Paris polyphylla Smith var. yunnanensis; antitumor activity; steroidal saponins