Cell biology of Candida albicans-host interactions.
Candida albicans is a commensal coloniser of most people and a pathogen of the immunocompromised or patients in which barriers that prevent dissemination have been disrupted. Both the commensal and pathogenic states involve regulation and adaptation to the host microenvironment. The pathogenic potential can be downregulated to sustain commensalism or upregulated to damage host tissue and avoid and subvert immune surveillance. In either case it seems as though the cell biology of this fungus has evolved to enable the establishment of different types of relationships with the human host. Here we summarise latest advances in the analysis of mechanisms that enable C. albicans to occupy different body sites whilst avoiding being eliminated by the sentinel activities of the human immune system.
The Aberdeen Fungal Group, School of Medicine, Medical Science and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB252ZD, UK.
Alessandra
A
da Silva Dantas
The Aberdeen Fungal Group, School of Medicine, Medical Science and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB252ZD, UK.
Kathy K
KK
Lee
The Aberdeen Fungal Group, School of Medicine, Medical Science and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB252ZD, UK.
Ingrida
I
Raziunaite
The Aberdeen Fungal Group, School of Medicine, Medical Science and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB252ZD, UK.
Katja
K
Schaefer
The Aberdeen Fungal Group, School of Medicine, Medical Science and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB252ZD, UK.
Jeanette
J
Wagener
The Aberdeen Fungal Group, School of Medicine, Medical Science and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB252ZD, UK.
Bhawna
B
Yadav
The Aberdeen Fungal Group, School of Medicine, Medical Science and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB252ZD, UK. Electronic address: n.gow@abdn.ac.uk.
Neil Ar
NA
Gow
D000222:Adaptation, Physiological; D000818:Animals; D002176:Candida albicans / Q000276:immunology / Q000472:pathogenicity / Q000502:physiology*; D002177:Candidiasis / Q000382:microbiology; D005656:Fungal Proteins / Q000276:immunology / Q000378:metabolism; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D051379:Mice; D013559:Symbiosis
D005656:Fungal Proteins
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