Unraveling Antibody Display: Systems Biology and Personalized Medicine.
The identification of combinatorial antibodies against many different targets in oncology, autoimmune, inflammatory and infectious diseases has uncovered novel strategies to control and prevent diseases' onset and progression, and represents the fastest growing market for the pharmaceutical industry. Phage Display has been successfully used in the identification of unknown targets, which combines shotgun approaches with high throughput selection schemes.



This specific review covers many aspects of combinatorial phage display technology starting from antibody selection strategies to its redesign for application purposes. Emphasis is specifically directed to how these biotherapeutics function on specific targets with an interactome view, especially within complex diseases.



Novel combinatorial antibodies will lead to improved interventions in cancer, autoimmune and infectious diseases; however, the very large genetic diversity associated with environmental variations highlight the importance of the personalized medicine using a system's biology approach. Therefore, combined therapies are expected in the near future.
Laboratory of Nanobiotechnology, Institute of Genetics and Biochemistry, Federal University of Uberlandia, Campus Umuarama, Bl 2E, Sl 248, Uberlandia, MG, Brazil.
Luiz Ricardo
LR
Goulart
Paula Souza
PS
Santos
Ana Paula
AP
Carneiro
Barbara Brasil
BB
Santana
Antonio C
AC
Vallinoto
Thaise Goncalves
TG
Araujo
D000906:Antibodies / Q000235:genetics / Q000276:immunology*; D001435:Bacteriophages / Q000235:genetics*; D006801:Humans; D019151:Peptide Library; D057285:Precision Medicine; D049490:Systems Biology
D000906:Antibodies; D019151:Peptide Library
Combinatorial antibodies; cell signaling; cell therapy; personalized medicine.; phage display; systems biology