Does Zinc Really "Metal" with Diabetes? The Epidemiologic Evidence.
Zinc (Zn) is important in a number of processes related to insulin secretion and insulin activity in peripheral tissues, making this element an interesting potential co-adjuvant in the treatment of patients with type 2 diabetes (T2D). This issue has been matter of interest in recent years. The available evidence is analyzed in this review. Information from epidemiologic studies evaluating the relationship between Zn and T2D is inconsistent. Furthermore, few studies examined the association between Zn status and insulin action and/or glucose homeostasis. In terms of usefulness of Zn as a preventive agent for T2D development, information is insufficient to reach firm conclusions. Results from Zn supplementation trials found some positive effects only in those with initial sub normal Zn status in a significant proportion of individuals. In conclusion, the effect of Zn on patients with type 2 diabetes is still an open question, and better study designs are needed to clarify the real impact and characteristics of the Zn-diabetes interaction.
Department of Nutrition, Faculty of Medicine, University of Chile, Independencia 1027, Postal Code 8380453, Santiago, Chile. mruz@med.uchile.cl.
Manuel
M
Ruz
Department of Nutrition, Faculty of Medicine, University of Chile, Independencia 1027, Postal Code 8380453, Santiago, Chile.
Fernando
F
Carrasco
Department of Nutrition, Faculty of Medicine, University of Chile, Independencia 1027, Postal Code 8380453, Santiago, Chile.
Andrés
A
Sánchez
Department of Nutrition, Faculty of Medicine, University of Chile, Independencia 1027, Postal Code 8380453, Santiago, Chile.
Alvaro
A
Perez
Department of Nutrition, Faculty of Medicine, University of Chile, Independencia 1027, Postal Code 8380453, Santiago, Chile.
Pamela
P
Rojas
D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000517:prevention & control*; D019587:Dietary Supplements; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D015032:Zinc / Q000008:administration & dosage* / Q000502:physiology
D006442:Glycated Hemoglobin; D015032:Zinc; C517652:hemoglobin A1c protein, human
Humans; Supplementation; Type 2 diabetes; Zinc
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