Relationship Between Accelerometer-Measured Activity and Self-Reported or Performance-Based Function in Older Adults with Severe Aortic Stenosis.
In older adults with aortic stenosis, we evaluated whether accelerometer-measured physical activity provides distinct clinical information apart from self-reported surveys or performance-based function tests. We employed wrist-mounted accelerometry in 52 subjects with severe aortic stenosis prior to transcatheter aortic valve replacement (TAVR). Daily daytime activity was estimated using the maximum 10 h of daily accelerometer-measured activity (M10) reported in activity counts. Subjects completed baseline surveys (New York Heart Association (NYHA), Short Form 12 (SF12), Kansas City Cardiomyopathy Questionnaire (KCCQ), EuroQol-5D (EQ-5D), Revised Life Orientation Test (LOT-R), Life Space, Detailed Activity Form) and performance-based function tests (Short Physical Performance Battery, 6-min walk test distance, grip strength) to estimate functional status. Simple and multiple linear regression models were used to evaluate the relationship between accelerometer-measured activity and survey data and performance-based function tests. Among all baseline surveys and performance-based function tests, the only statistically significant univariable relationships identified were weak, negative associations between M10 and SF-12 Mental Composite Score (R2=0.1970,P=0.04) and between M10 and grip strength (R2=0.1568,P=0.004). Neither multiple linear regression of overall survey data (R2=0.6159,P=0.23) nor performance-based function tests (R2=0.1743,P=0.10) correlated with M10. Self-reported surveys and performance-based function tests are not meaningfully correlated with daytime accelerometer-measured activity. The results of our study suggest that accelerometer-measured physical activity provides distinct clinical information apart from self-reported surveys or performance-based function tests.
Columbia University Medical Center, 622 W 168th Street, New York, NY 10032, USA.
Yufei
Y
Tang
Columbia University Medical Center, 161 Fort Washington Avenue, 6th Floor Herbert Irving Pavilion, New York, NY 10032, USA.
Philip
P
Green
Columbia University Medical Center, 161 Fort Washington Avenue, 6th Floor Herbert Irving Pavilion, New York, NY 10032, USA.
Mathew
M
Maurer
Columbia University Medical Center, 161 Fort Washington Avenue, 6th Floor Herbert Irving Pavilion, New York, NY 10032, USA.
Rosa
R
Lazarte
Columbia University Medical Center, 161 Fort Washington Avenue, 6th Floor Herbert Irving Pavilion, New York, NY 10032, USA.
Jonathan Rubin
JR
Kuzniecky
Georgetown University School of Medicine, 3900 Reservoir Rd NW, Washington, DC 20007, USA.
Ming Yang
MY
Hung
National Institute on Aging, Building 31, Room 5C27, 31 Center Drive, MSC 2292, Bethesda, MD 20892, USA.
Melissa
M
Garcia
Columbia University Medical Center, 161 Fort Washington Avenue, 6th Floor Herbert Irving Pavilion, New York, NY 10032, USA.
Susheel
S
Kodali
National Institute on Aging, Building 31, Room 5C27, 31 Center Drive, MSC 2292, Bethesda, MD 20892, USA.
Tamara
T
Harris
Accelerometer; Activity; Aortic stenosis; Heart failure; Valves
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