The importance of dose optimization prior to initiation of a registration trial.
Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland.
Nam A
NA
Rahman
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D006801:Humans
D000970:Antineoplastic Agents