[Update on molecular classifications and new histological classification of bladder cancer].
OBJECTIVE
Comment the new WHO histological classification of tumors of the urinary system and male genital organs 2016 and expose the state of art about urothelial carcinogenesis and molecular modifications of bladder cancer, with the consequences on the treatments.


METHODS
A systematic review of the literature search was performed from the data base PubMed, focused on the following keywords: "bladder cancer", "molecular", "subtypes".


RESULTS
The new WHO histological classification of tumors of the urinary system 2016 confirm the importance of pathology in determining the care of patients, especially the grade, the histological type and the infiltration, while taking into account the difficulties. In 2014, the Cancer Genome Atlas reported genetic modifications of bladder cancer. Recently, several studies explored molecular anomalies of bladder cancer and elaborated molecular classifications, analyzing their predictive value. According to the groups, different molecular subtype had been defined: Urobasal A, Urobasal B, genomically unstable, infiltrated, squamous cell carcinoma-like and p53-like luminal bladder cancers. This latter subgroup seems to be chemoresistant.


CONCLUSIONS
The molecular biology and classifications allow a better understanding of bladder cancer and could complete in near future histological data to improve patient management.
Service d'anatomie et cytologie pathologiques, hôpital La Pitié-Salpêtrière, UPMC Paris VI, 47-83, boulevard de l'Hopital, 75013 Paris, France. Electronic address: justinevarinot@hotmail.com.
J
J
Varinot
Service d'anatomie et cytologie pathologiques, hôpital La Pitié-Salpêtrière, UPMC Paris VI, 47-83, boulevard de l'Hopital, 75013 Paris, France.
A
A
Furudoï
Service d'urologie, hôpital La Pitié-Salpêtrière, UPMC Paris VI, 47-83, boulevard de l'Hopital, 75013 Paris, France.
M
M
Roupret
Service d'anatomie et cytologie pathologiques, hôpital La Pitié-Salpêtrière, UPMC Paris VI, 47-83, boulevard de l'Hopital, 75013 Paris, France.
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E
Compérat
D006801:Humans; D025202:Molecular Diagnostic Techniques; D001749:Urinary Bladder Neoplasms / Q000145:classification* / Q000235:genetics / Q000473:pathology*
Bladder cancer; Cancer de vessie; Carcinogenesis; Carcinogenèse; Classification; Histologie; Molecular; Moléculaire; Pathology