Single-Cell Approaches: Pandora's Box of Developmental Mechanisms.
Single-cell approaches are providing a new lexicon of developmental cell biology by revealing heterogeneities in seemingly uniform cellular populations. By bridging scales, single-cell approaches should, in principle, galvanize our understanding of how individual cells adopt distinct fates as they build complex tissues.
Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: hadj@mskcc.org.
Anna-Katerina
AK
Hadjantonakis
Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK. Electronic address: ama11@hermes.cam.ac.uk.
Alfonso Martinez
AM
Arias
D000818:Animals; D004622:Embryo, Mammalian; D047108:Embryonic Development / Q000235:genetics*; D020869:Gene Expression Profiling / Q000379:methods*; D018507:Gene Expression Regulation, Developmental; D051379:Mice; D059010:Single-Cell Analysis / Q000379:methods*