Is bioresorbable vascular scaffold acute recoil affected by baseline renal function and scaffold selection?
OBJECTIVE
The aim of the present study was to investigate the relationship between glomerular filtration rate (GFR) and acute post-scaffold recoil (PSR) in patients undergoing bioresorbable scaffold (BVS) implantation.


METHODS
We included 130 patients who underwent everolimus-eluting BVS device (Absorb BVS; Abbott Vascular, Santa Clara, CA, USA) or the novolimus-eluting BVS device (Elixir Medical Corporation) implantations for single or multi-vessel disease. Clinical, angiographic variables and procedural characteristics were defined and pre-procedural GFR was calculated for each patient. Post-procedural angiographic parameters of each patient were analyzed. Primary objective of the study was to evaluate the effect of GFR on angiographic outcomes after BVS implantation while secondary objective was to compare post-procedural angiographic results between the two BVS device groups.


RESULTS
Baseline clinical characteristics and angiographic parameters were similar between the two BVS groups. Post-procedural angiographic analysis revealed significantly lower PSR in the DESolve group than the Absorb group (0.10±0.04 vs. 0.13±0.05, p: 0.003). When PSR in the whole study population was evaluated, it was positively correlated with age, tortuosity , calcification and PBR as there was a negative correlation between GFR. Besides GFR were found to be independent predictors for PSR in all groups and the whole study population.


CONCLUSIONS
In patients undergoing BVS implantation, pre-procedural low GFR is associated with increased post-procedural PSR. Calcification, age, PBR, dyslipidemia and tortuosity are other independent risk factors for PSR. DESolve has lower PSR when compared with Absorb.
Medipol University, Faculty of Medicine, Cardiology Department, Istanbul, Turkey. Electronic address: haci.gunes@medipol.com.tr.
Haci Murat
HM
Gunes
Medipol University, Faculty of Medicine, Cardiology Department, Istanbul, Turkey.
Filiz Kizilirmak
FK
Yılmaz
Medipol University, Faculty of Medicine, Cardiology Department, Istanbul, Turkey.
Tayyar
T
Gokdeniz
Medipol University, Faculty of Medicine, Cardiology Department, Istanbul, Turkey.
Gultekin Gunhan
GG
Demir
Medipol University, Faculty of Medicine, Cardiology Department, Istanbul, Turkey.
Ekrem
E
Guler
Medipol University, Faculty of Medicine, Cardiology Department, Istanbul, Turkey.
Gamze Babur
GB
Guler
Medipol University, Faculty of Medicine, Cardiology Department, Istanbul, Turkey.
Oğuz
O
Karaca
Medipol University, Faculty of Medicine, Cardiology Department, Istanbul, Turkey.
Beytullah
B
Cakal
Medipol University, Faculty of Medicine, Cardiology Department, Istanbul, Turkey.
Ersin
E
İbişoğlu
Medipol University, Faculty of Medicine, Cardiology Department, Istanbul, Turkey.
Bilal
B
Boztosun
D020341:Absorbable Implants / Q000009:adverse effects*; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation / Q000379:methods; D001807:Blood Vessel Prosthesis / Q000009:adverse effects*; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology / Q000601:surgery; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011300:Preoperative Care / Q000379:methods; D011475:Prosthesis Failure / Q000209:etiology*; D012307:Risk Factors; D054457:Tissue Scaffolds / Q000009:adverse effects*; D014421:Turkey / Q000453:epidemiology
Bioresorbable vascular scaffold; Glomerular filtration rate; Stent recoiling