Recent advances in orally administered cell-specific nanotherapeutics for inflammatory bowel disease.
Inflammatory bowel disease (IBD) is a chronic relapsing disease in gastrointestinal tract. Conventional medications lack the efficacy to offer complete remission in IBD therapy, and usually associate with serious side effects. Recent studies indicated that nanoparticle-based nanotherapeutics may offer precise and safe alternative to conventional medications via enhanced targeting, sustained drug release, and decreased adverse effects. Here, we reviewed orally cell-specific nanotherapeutics developed in recent years. In addition, the various obstacles for oral drug delivery are also reviewed in this manuscript. Orally administrated cell-specific nanotherapeutics is expected to become a novel therapeutic approach for IBD treatment.
Xiao-Ying Si, Bo Xiao, Institute for Clean Energy and Advanced Materials, Faculty of Materials and Energy, Southwest University, Chongqing 400715, China.
Xiao-Ying
XY
Si
Xiao-Ying Si, Bo Xiao, Institute for Clean Energy and Advanced Materials, Faculty of Materials and Energy, Southwest University, Chongqing 400715, China.
Didier
D
Merlin
Xiao-Ying Si, Bo Xiao, Institute for Clean Energy and Advanced Materials, Faculty of Materials and Energy, Southwest University, Chongqing 400715, China.
Bo
B
Xiao
D000284:Administration, Oral; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry; D011992:Endosomes / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism; D027261:Fusion Regulatory Protein-1 / Q000737:chemistry; D005690:Galactose / Q000737:chemistry; D041981:Gastrointestinal Tract / Q000187:drug effects; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D015212:Inflammatory Bowel Diseases / Q000628:therapy*; D008358:Mannose / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D010539:Permeability; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D017382:Reactive Oxygen Species / Q000378:metabolism; D011990:Receptors, Transferrin / Q000737:chemistry
D004337:Drug Carriers; D027261:Fusion Regulatory Protein-1; D020100:Hydrogels; D004364:Pharmaceutical Preparations; D017382:Reactive Oxygen Species; D011990:Receptors, Transferrin; D006820:Hyaluronic Acid; D008358:Mannose; D005690:Galactose
Cell-specificity; Inflammatory bowel disease; Nanotherapeutic; Oral administration
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