Insight from animal models of environmentally driven epigenetic changes in the developing and adult brain.
The efforts of many neuroscientists are directed toward understanding the appreciable plasticity of the brain and behavior. In recent years, epigenetics has become a core of this focus as a prime mechanistic candidate for behavioral modifications. Animal models have been instrumental in advancing our understanding of environmentally driven changes to the epigenome in the developing and adult brain. This review focuses mainly on such discoveries driven by adverse environments along with their associated behavioral outcomes. While much of the evidence discussed focuses on epigenetics within the central nervous system, several peripheral studies in humans who have experienced significant adversity are also highlighted. As we continue to unravel the link between epigenetics and phenotype, discerning the complexity and specificity of epigenetic changes induced by environments is an important step toward understanding optimal development and how to prevent or ameliorate behavioral deficits bred by disruptive environments.
University of Delaware,Newark.
Tiffany S
TS
Doherty
University of Delaware,Newark.
Tania L
TL
Roth
D000328:Adult; D000818:Animals; D001921:Brain / Q000502:physiology; D019175:DNA Methylation / Q000235:genetics; D004195:Disease Models, Animal; D044127:Epigenesis, Genetic / Q000235:genetics*; D005260:Female; D018392:Genomic Imprinting / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008957:Models, Genetic; D010641:Phenotype; D047489:Preconception Injuries / Q000235:genetics; D012931:Social Environment
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