A Computational Efficient Method to Assess the Sensitivity of Finite-Element Models: An Illustration With the Hemipelvis.
Assessing the sensitivity of a finite-element (FE) model to uncertainties in geometric parameters and material properties is a fundamental step in understanding the reliability of model predictions. However, the computational cost of individual simulations and the large number of required models limits comprehensive quantification of model sensitivity. To quickly assess the sensitivity of an FE model, we built linear and Kriging surrogate models of an FE model of the intact hemipelvis. The percentage of the total sum of squares (%TSS) was used to determine the most influential input parameters and their possible interactions on the median, 95th percentile and maximum equivalent strains. We assessed the surrogate models by comparing their predictions to those of a full factorial design of FE simulations. The Kriging surrogate model accurately predicted all output metrics based on a training set of 30 analyses (R2 = 0.99). There was good agreement between the Kriging surrogate model and the full factorial design in determining the most influential input parameters and interactions. For the median, 95th percentile and maximum equivalent strain, the bone geometry (60%, 52%, and 76%, respectively) was the most influential input parameter. The interactions between bone geometry and cancellous bone modulus (13%) and bone geometry and cortical bone thickness (7%) were also influential terms on the output metrics. This study demonstrates a method with a low time and computational cost to quantify the sensitivity of an FE model. It can be applied to FE models in computational orthopaedic biomechanics in order to understand the reliability of predictions.
Medical Device Research Institute, School of Computer Science, Engineering and Mathematics, Flinders University, 1284 South Road, Adelaide SA 5042, Australia e-mail: dermot.orourke@flinders.edu.au.
Dermot
D
O'Rourke
Medical Device Research Institute, School of Computer Science, Engineering and Mathematics, Flinders University, 1284 South Road, Adelaide SA 5042, Australia e-mail: saulo.martelli@flinders.edu.au.
Saulo
S
Martelli
Medical Device Research Institute, School of Computer Science, Engineering and Mathematics, Flinders University, 1284 South Road, Adelaide SA 5042, Australia e-mail: murk.bottema@flinders.edu.au.
Murk
M
Bottema
Medical Device Research Institute, School of Computer Science, Engineering and Mathematics, Flinders University, 1284 South Road, Adelaide SA 5042, Australia e-mail: mark.taylor@flinders.edu.au.
Mark
M
Taylor
D000368:Aged; D000465:Algorithms; D019245:Compressive Strength / Q000502:physiology; D003198:Computer Simulation; D055119:Elastic Modulus / Q000502:physiology; D020342:Finite Element Analysis; D006801:Humans; D008297:Male; D008954:Models, Biological; D010384:Pelvic Bones / Q000502:physiology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical; D013718:Tensile Strength / Q000502:physiology; D016474:Weight-Bearing / Q000502:physiology*