Association between ambient air pollution and proliferation of umbilical cord blood cells.
It has been established as a common knowledge that ambient air pollution (AAP) has an adverse effect on human health. The pathophysiological mechanism of this impact is likely to be related to the oxidative stress. In the current study we estimate the association between AAP and cell proliferation (CP) of umbilical cord blood cells, representing maternal organism most proximal to the fetal body. Blood samples were tested for proliferation in 292 enrolled Arab-Bedouin women at delivery (July 2012-March 2013). The estimates of AAP were defined by a hybrid satellite based model predicting both PM2.5(particles<2.5µm in diameter) and PM10(particles<10µm in diameter) as well as monitoring stations for gaseous air pollutants. Risk estimates of pollution exposure were adjusted to medical history, household risk factors and meteorological factors on the day of delivery or one week prior. Ambient ozone (O3) levels on 1, 2, 3and 4 days prior to delivery were associated with lower CP (Prevalence ratio (PR)=0.92, 0.92, 0.93, 0.93, respectively). Increase in inter-quartile range (IOR) of PM2.5one day before delivery was associated with 9% increase in CP levels (PR=1.09). The positive direction in association was changed to negative association with CP for PM2.5levels measured at more distant time periods (PR=0.90 and 0.93 for lags 5 and 6 days, respectively). Investigation of PM10levels indicated a similar pattern (PR=1.05 for pollution values recorded one day before delivery and 0.93 and 0.95 for lags of 5 and 6 days, respectively). Carbon monoxide (CO) levels were associated with lower CP on the day of delivery and 1day prior (PR=0.92 and PR=0.94). To conclude, the levels of cell proliferation of umbilical cord blood cells appear to be associated with the AAP. More studies are needed to support our findings.
Department of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. Electronic address: novack@bgu.ac.il.
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Novack
Clinical Research Center, Soroka University Medical Center, Beer-Sheva, Israel.
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Yitshak-Sade
Division of Neonatology, University Medical Center, Beer-Sheva, Israel.
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Landau
Department of Geography, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
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Kloog
Department of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
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Sarov
Environmental Epidemiology Department, Ministry of Health, Jerusalem, Israel; Ashkelon Academic College, Ashkelon, Israel.
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Karakis
D000293:Adolescent; D000328:Adult; D000393:Air Pollutants / Q000032:analysis / Q000633:toxicity*; D001773:Blood Cells / Q000187:drug effects* / Q000473:pathology; D002248:Carbon Monoxide / Q000032:analysis / Q000633:toxicity; D049109:Cell Proliferation / Q000187:drug effects*; D005260:Female; D005312:Fetal Blood / Q000166:cytology / Q000187:drug effects*; D005865:Gestational Age; D006801:Humans; D007557:Israel; D018811:Maternal Exposure / Q000009:adverse effects*; D008875:Middle Aged; D015999:Multivariate Analysis; D009585:Nitrogen Dioxide / Q000032:analysis / Q000633:toxicity; D010126:Ozone / Q000032:analysis / Q000633:toxicity; D052638:Particulate Matter / Q000032:analysis / Q000633:toxicity*; D011247:Pregnancy; D012959:Socioeconomic Factors; D013458:Sulfur Dioxide / Q000032:analysis / Q000633:toxicity; D055815:Young Adult
D000393:Air Pollutants; D052638:Particulate Matter; D013458:Sulfur Dioxide; D010126:Ozone; D002248:Carbon Monoxide; D009585:Nitrogen Dioxide
Ambient air pollution; Biomarker; Cell proliferation; Health outcomes; Umbilical cord