The shared and unique genetic relationship between mental well-being, depression and anxiety symptoms and cognitive function in healthy twins.
Alterations to cognitive function are often reported with depression and anxiety symptoms, yet few studies have examined the same associations with mental well-being. This study examined the association between mental well-being, depression and anxiety symptoms and cognitive function in 1502 healthy adult monozygotic (MZ) and dizygotic (DZ) twins, and the shared/unique contribution of genetic (G) and environmental (E) variance. Using linear mixed models, mental well-being was positively associated (p < .01) with sustained attention (β = 0.127), inhibition (β = 0.096), cognitive flexibility (β = 0.149), motor coordination (β = 0.114) and working memory (β = 0.156), whereas depression and anxiety symptoms were associated (p < .01) with poorer sustained attention (β = -0.134), inhibition (β = -0.139), cognitive flexibility (β = -0.116) and executive function (β = -0.139). Bivariate twin modelling showed well-being shared a small environmental correlation with motor coordination and a small genetic correlation with working memory. Trivariate twin modelling showed well-being shared a small genetic correlation with inhibition, whereas depression and anxiety symptoms shared a small environmental correlation with inhibition. The remaining variance was mostly driven by unique G and/or E variance. Overall, well-being and depression and anxiety symptoms show both independent and shared relationships with cognitive functions but this is largely attributable to unique G or E variance and small shared G/E variance between pairs of variables.
a The Brain Dynamics Centre, Sydney Medical School , University of Sydney , Sydney , Australia.|b Westmead Institute for Medical Research, Westmead Hospital , Westmead , NSW , Australia.|c Discipline of Psychiatry, Sydney Medical School , University of Sydney , Sydney , Australia.
Kylie M
KM
Routledge
a The Brain Dynamics Centre, Sydney Medical School , University of Sydney , Sydney , Australia.|b Westmead Institute for Medical Research, Westmead Hospital , Westmead , NSW , Australia.|d Neuroscience Research Australia , Randwick NSW , Australia.
Karen L O
KLO
Burton
e Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine , Stanford University , Stanford , CA , USA.|f MIRECC VISN21, VA Palo Alto Health Care System , CA , USA.
Leanne M
LM
Williams
a The Brain Dynamics Centre, Sydney Medical School , University of Sydney , Sydney , Australia.|b Westmead Institute for Medical Research, Westmead Hospital , Westmead , NSW , Australia.|c Discipline of Psychiatry, Sydney Medical School , University of Sydney , Sydney , Australia.
Anthony
A
Harris
d Neuroscience Research Australia , Randwick NSW , Australia.|g School of Medicine , University of New South Wales , Sydney , NSW , Australia.
Peter R
PR
Schofield
h School of Psychology , Flinders University , Bedford Park , South Australia , Australia.|i Brain Clinics Australia , Adelaide , South Australia , Australia.
C Richard
CR
Clark
a The Brain Dynamics Centre, Sydney Medical School , University of Sydney , Sydney , Australia.|b Westmead Institute for Medical Research, Westmead Hospital , Westmead , NSW , Australia.|c Discipline of Psychiatry, Sydney Medical School , University of Sydney , Sydney , Australia.|d Neuroscience Research Australia , Randwick NSW , Australia.|j School of Psychology , University of New South Wales , Sydney , NSW , Australia.
Justine M
JM
Gatt
D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000235:genetics* / Q000523:psychology; D003071:Cognition / Q000502:physiology*; D003863:Depression / Q000235:genetics* / Q000523:psychology; D056344:Executive Function / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology; D008603:Mental Health; D008875:Middle Aged; D008957:Models, Genetic; D008960:Models, Psychological; D014429:Twins, Dizygotic / Q000235:genetics / Q000523:psychology; D014430:Twins, Monozygotic / Q000235:genetics / Q000523:psychology; D055815:Young Adult
Well-being; attention; executive function; inhibition; mental health; twins