Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine.
Elevation of intraocular pressure (IOP) due to therapeutic use of glucocorticoids is called steroid-induced ocular hypertension (SIOH); this can lead to steroid-induced glaucoma (SIG). Glucocorticoids initiate signaling cascades ultimately affecting expression of hundreds of genes; this provides the potential for a highly personalized pharmacological response. Studies attempting to define genetic risk factors were undertaken early in the history of glucocorticoid use, however scientific tools available at that time were limited and progress stalled. In contrast, significant advances were made over the ensuing years in defining disease pathophysiology. As the genomics age emerged, it appeared the time was right to renew investigation into genetics. Pharmacogenomics is an unbiased discovery approach, not requiring an underlying hypothesis, and provides a way to pinpoint clinically significant genes and pathways that could not have been discovered any other way. Results of the first genome-wide association study to identify polymorphisms associated with SIOH, and follow-up on two novel genes linked to the disorder, GPR158 and HCG22, is discussed in the second half of the article. However, knowledge of genetic variants determining response to steroids in the eye also has value in its own right as a predictive and diagnostic tool. This article concludes with a discussion of how the Precision Medicine Initiative®, announced by U.S. President Obama in his 2015 State of the Union address, is beginning to touch the practice of ophthalmology. It is argued that SIOH/SIG may provide one of the next opportunities for effective application of precision medicine.
USC Institute for Genetic Medicine and Department of Cell & Neurobiology, Keck School of Medicine of USC, University of Southern California, 2250 Alcatraz St., Suite 240, Los Angeles, CA, 90089, USA. Electronic address: efini@med.usc.edu.
M Elizabeth
ME
Fini
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 3880 Tamiami Trail North, Naples, FL, 34103, USA. Electronic address: sschwartz2@med.miami.edu.
Stephen G
SG
Schwartz
Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1905 W Taylor St., Suite 235, Chicago, IL, 60612, USA. Electronic address: rgao@uic.edu.
Xiaoyi
X
Gao
USC Institute for Genetic Medicine, USC Roski Eye Institute and Department of Ophthalmology, Keck School of Medicine of USC, University of Southern California, 2250 Alcatraz St., Suite 240, Los Angeles, CA, 90089, USA. Electronic address: shinwuje@med.usc.edu.
Shinwu
S
Jeong
USC Institute for Genetic Medicine, Keck School of Medicine of USC, University of Southern California, 2250 Alcatraz St., Suite 240, Los Angeles, CA, 90089, USA. Electronic address: nitinusc@gmail.com.
Nitin
N
Patel
USC Institute for Genetic Medicine, Keck School of Medicine of USC, University of Southern California, 2250 Alcatraz St., Suite 240, Los Angeles, CA, 90089, USA. Electronic address: itakura@med.usc.edu.
Tatsuo
T
Itakura
Cornea Research Foundation of America, 9002 North Meridian Street, Indianapolis, IN, 46260, USA. Electronic address: marianneprice@cornea.org.
Marianne O
MO
Price
Price Vision Group, 9002 North Meridian Street, Indianapolis, IN, 46260, USA. Electronic address: francisprice@pricevisiongroup.net.
Francis W
FW
Price
Office of the Dean, USC Roski Eye Institute and Department of Ophthalmology, Keck School of Medicine of USC, University of Southern California, 1975 Zonal Ave., KAM 500, Los Angeles, CA, 90089, USA. Electronic address: Rohit.Varma@med.usc.edu.
Rohit
R
Varma
Department of Ophthalmology and Department of Biomedical Engineering, Duke University, AERI Room 4008, 2351 Erwin Rd, Durham, NC, 27705, USA. Electronic address: dan.stamer@duke.edu.
W Daniel
WD
Stamer
D019468:Disease Management; D055106:Genome-Wide Association Study; D005901:Glaucoma / Q000139:chemically induced* / Q000628:therapy; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D009798:Ocular Hypertension / Q000139:chemically induced* / Q000628:therapy; D010597:Pharmacogenetics / Q000379:methods*; D057285:Precision Medicine / Q000379:methods*
D005938:Glucocorticoids
Glaucoma; Glucocorticoid; Ocular hypertension; Ophthalmology; Pharmacogenomics; Precision medicine
N Engl J Med. 2009 Mar 12;360(11):1113-24
19279343
Hum Genet. 2014 Jan;133(1):41-57
24002674
J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1:S4-9
24833586
Invest Ophthalmol Vis Sci. 2016 Jul 01;57(8):3698-707
27403998
J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):202-12
24564495
Cell. 2007 Feb 23;128(4):693-705
17320507
Tissue Antigens. 1976 Apr;7(4):193-200
941127
Prog Retin Eye Res. 2002 Jul;21(4):395-428
12150989
Arch Ophthalmol. 1966 Oct;76(4):484-7
5928135
Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1778-83
10677534
Cornea. 2014 Sep;33(9):880-6
25062336
Eye (Lond). 1988;2 Suppl:S19-26
3076147
Arch Ophthalmol. 2001 Nov;119(11):1674-8
11709019
Exp Eye Res. 2009 Apr;88(4):683-8
19385040
Mol Vis. 2010 Jan 16;16:61-71
20090922
Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11776-81
10518526
Ophthalmic Genet. 2008 Dec;29(4):166-70
19005987
Biochim Biophys Acta. 2007 Jul;1773(7):1087-94
17540466
Prog Mol Biol Transl Sci. 2015;134:315-42
26310163
Dig Dis Sci. 1999 Jun;44(6):1208-15
10389698
Invest Ophthalmol Vis Sci. 2005 Feb;46(2):568-78
15671284
Mol Cell. 2010 Jun 11;38(5):662-74
20541999
Clin Exp Rheumatol. 2011 Sep-Oct;29(5 Suppl 68):S-5-12
22018177
Br J Ophthalmol. 2005 Nov;89(11):1500-5
16234461
PLoS One. 2013 Dec 18;8(12):e82301
24367514
Retina. 2006 Oct;26(8):889-95
17031288
J Cell Biol. 2013 Jan 7;200(1):9-19
23295347
Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4447-59
26193921
Science. 2005 Apr 15;308(5720):385-9
15761122
Nat Rev Genet. 2010 Apr;11(4):241-6
20300088
BMC Med Genomics. 2009 Sep 10;2:58
19744340
N Engl J Med. 2015 Feb 26;372(9):793-5
25635347
Invest Ophthalmol. 1965 Apr;4:187-97
14283012
Invest Ophthalmol Vis Sci. 1992 Jun;33(7):2242-50
1607235
Exp Eye Res. 1992 Jun;54(6):879-83
1521580
Oncogene. 2012 Feb 2;31(5):552-62
21706047
Am J Physiol Cell Physiol. 2015 Aug 15;309(4):C205-14
26040898
Arthritis Rheum. 1987 Nov;30(11):1254-64
2825726
Prog Retin Eye Res. 2005 Sep;24(5):612-37
15919228
Cornea. 2005 Nov;24(8 Suppl):S2-S11
16227819
Science. 1998 May 15;280(5366):1077-82
9582121
J Biol Chem. 2015 May 29;290(22):13622-39
25792749
Invest Ophthalmol Vis Sci. 2010 Jan;51(1):308-18
19696167
Trans Ophthalmol Soc U K (1962). 1966;86:539-78
4959867
Am J Hum Genet. 2012 Feb 10;90(2):321-30
22325361
JAMA Ophthalmol. 2015 Sep;133(9):1022-9
26086920
Gene Ther. 2016 May;23(5):438-49
26855269
Biochim Biophys Acta. 2015 Mar;1852(3):379-85
25483712
J Exp Med. 1972 Apr 1;135(4):719-34
4336123
Exp Eye Res. 2009 Apr;88(4):724-8
19046967
Ophthalmology. 2006 Jun;113(6):1020-7
16690128
Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1255-63
18952927
Invest Ophthalmol Vis Sci. 2012 May 04;53(5):2467-9
22562842
Cornea. 2009 Sep;28(8):865-70
19654531
Br J Ophthalmol. 1996 May;80(5):389-93
8695555
Ann N Y Acad Sci. 2006 Jun;1069:1-9
16855130
Invest Ophthalmol Vis Sci. 2008 May;49(5):1932-9
18436825
Prog Retin Eye Res. 1999 Sep;18(5):629-67
10438153
Curr Drug Targets CNS Neurol Disord. 2002 Feb;1(1):105-21
12769637
Arch Ophthalmol. 1992 May;110(5):699-702
1580849
Genet Med. 2015 Apr;17(4):253-261
25412400
Invest Ophthalmol Vis Sci. 2012 Oct 09;53(11):7043-51
22956608
Exp Eye Res. 2004 Nov;79(5):649-63
15500824
Invest Ophthalmol Vis Sci. 1989 Sep;30(9):2012-22
2674051
Am J Ophthalmol. 1975 Jan;79(1):92-7
1110208
Ophthalmic Surg Lasers Imaging. 2010 Mar 09;:1-6
20337278
Genet Epidemiol. 2008 May;32(4):381-5
18348202
Invest Ophthalmol Vis Sci. 2007 Jul;48(7):3184-94
17591888
Curr Ophthalmol Rep. 2013 Sep;1(3):
24224143
Mol Vis. 2000 Jul 28;6:132-43
10930474
J Cell Biol. 1983 Aug;97(2):416-24
6684121
Invest Ophthalmol Vis Sci. 2000 Mar;41(3):619-23
10711672
J Biol Chem. 2005 Aug 12;280(32):28917-26
15944158
Ophthalmology. 2011 Dec;118(12):2453-60
21764136
Invest Ophthalmol Vis Sci. 2011 Dec 09;52(13):9438-44
22039240
Invest Ophthalmol Vis Sci. 2010 Jun;51(6):3029-41
20089870
Exp Eye Res. 1986 May;42(5):443-55
3720863
J Clin Endocrinol Metab. 2005 Nov;90(11):5978-84
16091495
J Cell Sci. 2003 Apr 1;116(Pt 7):1157-73
12615960
Invest Ophthalmol Vis Sci. 2011 Nov 07;52(12):8636-45
21980000
Eur J Hum Genet. 2005 Jul;13(7):793-4
15856069
Clin Genet. 2013 Aug;84(2):132-41
23701314
Zhonghua Yan Ke Za Zhi. 2006 May;42(5):431-4
16762238
Invest Ophthalmol Vis Sci. 2008 May;49(5):1886-97
18436822
J Glaucoma. 2013 Sep;22(7):517-25
22828004
Nat Biotechnol. 2012 Nov;30(11):1117-24
23138311
Invest Ophthalmol Vis Sci. 2012 Feb 21;53(2):857-66
22205602
Hum Mol Genet. 2007 Mar 15;16(6):609-17
17317787
Curr Eye Res. 1994 Jan;13(1):51-63
8156826
Invest Ophthalmol Vis Sci. 2006 May;47(5):1956-67
16639003
Nat Genet. 2011 Jun;43(6):574-8
21532571
J Pathol. 2008 Jan;214(2):199-210
18161745
Exp Eye Res. 2005 Jul;81(1):1-4
15978248
Kidney Int. 2003 Jun;63(6):2028-36
12753290
Invest Ophthalmol Vis Sci. 1981 Nov;21(5):714-27
7298275
Am J Ophthalmol. 1992 May 15;113(5):508-12
1575224
West J Med. 1979 Jun;130(6):542-3
18748429
Trans Ophthalmol Soc U K (1962). 1965;85:295-305
5227191
Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9362-7
19474294
Invest Ophthalmol Vis Sci. 2012 Jan 01;53(1):117
23065596
Eye (Lond). 2011 May;25(5):587-95
21562585
Invest Ophthalmol Vis Sci. 2002 Apr;43(4):1068-76
11923248
Arch Ophthalmol. 1997 Mar;115(3):375-83
9076211
Am J Hum Genet. 1994 Jan;54(1):62-70
8279471
Exp Eye Res. 2015 Dec;141:15-22
26051991
Mol Vis. 2013;19:684-95
23559862
Hum Genet. 2011 Feb;129(2):117-28
20981447
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1978 Sep 11;207(4):291-7
311598
N Engl J Med. 1998 Apr 9;338(15):1022-7
9535666
Aliment Pharmacol Ther. 1996;10 Suppl 2:81-90; discussion 91-2
8899106
Invest Ophthalmol Vis Sci. 2006 Apr;47(4):1491-9
16565384
J Biol Chem. 2014 Jun 6;289(23):16349-61
24755226
Invest Ophthalmol Vis Sci. 1992 Aug;33(9):2631-40
1639610
Arch Ophthalmol. 1978 Dec;96(12):2207-8
718510
BMC Biol. 2010 Feb 02;8:11
20122254
Invest Ophthalmol Vis Sci. 2013 Mar 01;54(3):2100-7
23462748
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1967;172(1):23-47
4967268
Am J Epidemiol. 1991 Nov 15;134(10):1102-10
1746520
Invest Ophthalmol Vis Sci. 2011 May 05;52(6):2952-9
21273548
J Neurosci. 2006 Nov 15;26(46):11903-14
17108164
J Clin Endocrinol Metab. 2004 Feb;89(2):892-7
14764810
JAMA Ophthalmol. 2015 Feb;133(2):182-90
25412195
Ophthalmology. 2012 Mar;119(3):536-40
22218143
Invest Ophthalmol Vis Sci. 2011 Jan 21;52(1):468-75
20861478
Ophthalmology. 2012 Nov;119(11):2408-10
22944025
Retina. 2016 Jun;36(6):1143-52
26871523
Graefes Arch Clin Exp Ophthalmol. 2008 Jul;246(7):1021-8
18386038
Invest Ophthalmol. 1965 Apr;4:198-205
14283013
J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):85-7
24304197
Invest Ophthalmol Vis Sci. 2013 Oct 03;54(10):6502-9
23963164
Longev Healthspan. 2013 May 02;2(1):8
24472098
Circulation. 2001 Jul 10;104(2):187-90
11447084
Invest Ophthalmol Vis Sci. 2005 Dec;46(12):4607-16
16303956
J Cell Biol. 2012 Jun 11;197(6):711-9
22689652
Mol Vis. 2006 Dec 02;12:1467-72
17167401
Cell Motil Cytoskeleton. 2005 Feb;60(2):83-95
15593281
Ann Ophthalmol. 1977 Sep;9(9):1075-80
143229
Exp Eye Res. 2002 Feb;74(2):161-72
11950226
Exp Eye Res. 2006 Jun;82(6):968-73
16516195
Ophthalmologica. 1997;211(3):126-39
9176893
Invest Ophthalmol Vis Sci. 2003 Oct;44(10):4237-46
14507867
Nat Rev Urol. 2015 Apr;12(4):182
25753095
Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5723-31
19643963
Drugs Aging. 1992 May-Jun;2(3):208-21
1351412
J Glaucoma. 1997 Aug;6(4):246-9
9264304
Exp Eye Res. 2015 Jan;130:9-16
25450062
PLoS One. 2013;8(2):e57843
23451275
Science. 1997 Jan 31;275(5300):668-70
9005853
Mol Vis. 2006 Jul 12;12:774-90
16862071
PLoS Genet. 2012;8(4):e1002654
22570617
Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2737-48
25813999
Trends Pharmacol Sci. 2006 Feb;27(2):92-6
16406086
PLoS One. 2012;7(9):e44902
23028669
Arch Ophthalmol. 2003 Jan;121(1):48-56
12523884
N Engl J Med. 2005 Oct 20;353(16):1711-23
16236742
JAMA Ophthalmol. 2013 Oct;131(10):1265-6
23949187
Am J Hum Genet. 1997 Feb;60(2):296-304
9012402
J Ocul Pharmacol Ther. 2002 Feb;18(1):53-63
11858615
Arch Ophthalmol. 1963 Oct;70:500-7
14078872
Invest Ophthalmol Vis Sci. 1982 Oct;23(4):464-78
7118506
Ophthalmology. 2011 Oct;118(10):1995-2000
21676464
Invest Ophthalmol Vis Sci. 2011 Apr 05;52(5):2147-52
21220561
Curr Opin Ophthalmol. 2006 Apr;17(2):163-7
16552251
Mol Vis. 2006 Feb 27;12:125-41
16541013
J Clin Endocrinol Metab. 1998 Jan;83(1):47-54
9435415
Graefes Arch Clin Exp Ophthalmol. 2001 Mar;239(3):199-207
11405069
Invest Ophthalmol Vis Sci. 1994 Jan;35(1):281-94
8300356
Invest Ophthalmol Vis Sci. 2007 Mar;48(3):1191-200
17325163
Mol Cell Biol. 2006 Nov;26(22):8427-36
16954374
Curr Eye Res. 1989 Oct;8(10):1071-82
2612196
Exp Eye Res. 1998 Jun;66(6):731-8
9657905
J Ocul Biol. 2013 Jun;1(1):3
24364042
PLoS Genet. 2012;8(5):e1002611
22570627
Prog Retin Eye Res. 1999 Jan;18(1):39-57
9920498
J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):267-76
24455976
Ocul Surf. 2015 Oct;13(4):346-9
26272274
Biochim Biophys Acta. 2013 Dec;1833(12):3306-3313
24100160
AMA Arch Ophthalmol. 1951 Aug;46(2):113-31
14856471
Methods Cell Biol. 2007;83:521-45
17613323
Acta Ophthalmol (Copenh). 1978 Jun;56(3):384-8
581129
J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):121-7
24506296
Exp Eye Res. 2017 May;158:124-136
27185161
Psychiatry Res. 2016 Aug 30;242:349-356
27344028
Eye (Lond). 2000 Jun;14 ( Pt 3A):375-83
11027004
Eur J Pharm Biopharm. 2015 Sep;95(Pt B):173-81
25957840
Exp Eye Res. 1973 Oct 10;17(1):19-31
4356557
Exp Eye Res. 2003 Dec;77(6):757-65
14609564
PLoS One. 2016 Apr 28;11(4):e0153354
27124111
Invest Ophthalmol Vis Sci. 2011 Oct 17;52(11):8068-75
21911581
Mediators Inflamm. 2016;2016:4083735
26903709
Int J Mol Med. 1998 Feb;1(2):339-46
9852235
Exp Eye Res. 1997 Apr;64(4):539-43
9227271
Am J Physiol. 1999 Aug;277(2):C330-42
10444410
Exp Eye Res. 2009 Apr;88(4):752-9
18977348
Arch Ophthalmol. 2002 Jun;120(6):714-20; discussion 829-30
12049575
Science. 1996 Sep 13;273(5281):1516-7
8801636
Exp Eye Res. 2015 Apr;133:112-25
25819459
Cell. 1975 Nov;6(3):289-98
802682
Am J Ophthalmol. 1986 May 15;101(5):535-41
3518464
Ophthalmology. 2014 Oct;121(10):1904-14
24907062
Crit Rev Clin Lab Sci. 2015;52(3):120-37
25597499
J Endocrinol. 2001 Jun;169(3):437-45
11375113
Arch Ophthalmol. 1981 May;99(5):819-23
7236083
Invest Ophthalmol Vis Sci. 2013 Dec 03;54(13):7903-9
24176900
Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2203-14
25711639
Curr Mol Med. 2010 Dec;10(9):824-40
21091423
Eye (Lond). 2006 Apr;20(4):407-16
15877093
Exp Eye Res. 2004 Jan;78(1):137-50
14667835
Ophthalmology. 2012 Oct;119(10):2125-32
22727177
Exp Eye Res. 2007 Jan;84(1):214-26
17219625
Invest Ophthalmol Vis Sci. 1998 Sep;39(10):1813-22
9727404
Eye (Lond). 2015 Oct;29(10):1285-98
26315706
Retina. 2009 Jan;29(1):38-45
18827733
Exp Eye Res. 2004 Mar;78(3):633-7
15106943
Invest Ophthalmol Vis Sci. 2009 Feb;50(2):669-73
18824726
Curr Eye Res. 1996 Sep;15(9):985-90
8921220
Respir Res. 2012 Aug 31;13:74
22938014
Exp Eye Res. 1993 Oct;57(4):461-8
8282032
Invest Ophthalmol Vis Sci. 2013 Jul 24;54(7):5000-11
23821196
EMBO Rep. 2006 Nov;7(11):1094-8
17077864
Br J Ophthalmol. 2006 Mar;90(3):262-7
16488940
Br J Pharmacol. 2009 Sep;158(1):5-14
19309353
Arch Ophthalmol. 1978 Dec;96(12):2204-6
718509
Invest Ophthalmol Vis Sci. 1999 Apr;40(5):887-96
10102285
J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):154-62
24517218
Invest Ophthalmol Vis Sci. 1987 Jun;28(6):945-53
3583633
Mol Cell Proteomics. 2013 Jan;12(1):194-206
23105009
Surv Ophthalmol. 2002 Nov-Dec;47(6):547-61
12504739
Exp Eye Res. 2001 Sep;73(3):281-9
11520103
Curr Drug Targets. 2010 Aug;11(8):978-93
20426763
Arch Ophthalmol. 1973 Oct;90(4):281-6
4795755
Front Oncol. 2016 Apr 27;6:106
27200294
Arch Ophthalmol. 1992 Jan;110(1):106-9
1731701
Am J Ophthalmol. 1988 Nov 15;106(5):607-12
3189477
Invest Ophthalmol Vis Sci. 1990 Dec;31(12):2568-71
2125032
Invest Ophthalmol Vis Sci. 1993 Nov;34(12):3386-95
8225873
Mol Vis. 2010 Apr 03;16:596-601
20376328
Ophthalmology. 2005 Dec;112(12):2131-6
16325708
Arch Ophthalmol. 1963 Oct;70:482-91
14078870
Biochem Biophys Res Commun. 2003 Dec 19;312(3):592-600
14680806
J Biol Chem. 1998 Mar 13;273(11):6341-50
9497363
Exp Eye Res. 2009 Apr;88(4):769-75
19114037
Hum Mol Genet. 2004 Apr 1;13 Spec No 1:R91-102
14764620
Nat Med. 2001 Mar;7(3):304-9
11231628
Science. 2001 Feb 16;291(5507):1304-51
11181995
Exp Eye Res. 2006 Apr;82(4):545-57
16386733
J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):110-20
24266581
Invest Ophthalmol Vis Sci. 2002 Jan;43(1):151-61
11773026
Ophthalmology. 2015 May;122(5):1040-8.e4
25704319
Surv Ophthalmol. 2000 Sep-Oct;45(2):91-105
11033036
Invest Ophthalmol Vis Sci. 2001 Jan;42(1):145-52
11133859
Science. 1983 Feb 18;219(4586):867-9
6681677
Mol Vis. 2015 Sep 17;21:1071-84
26396484
Arch Ophthalmol. 2011 May;129(5):545-53
21220619
Mol Cell Biol. 2009 Aug;29(15):4325-39
19487460
Am J Physiol Cell Physiol. 2010 Mar;298(3):C749-63
19940066
FASEB J. 2007 Feb;21(2):402-14
17185747
Invest Ophthalmol Vis Sci. 2000 May;41(6):1386-91
10798654
J Biol Chem. 2011 Feb 4;286(5):3177-84
21149445
Genome Med. 2013 Nov 29;5(11):105
24289319
Hum Mutat. 2008 Feb;29(2):207-11
17966125
Mol Vis. 2002 Mar 06;8:32-44
11889464
Invest Ophthalmol Vis Sci. 2010 Apr;51(4):2067-76
19959644
Arch Ophthalmol. 2007 Feb;125(2):205-12
17296896
Clin Pharmacol Ther. 2003 Jul;74(1):44-52
12844134
Invest Ophthalmol Vis Sci. 2002 Dec;43(12):3691-7
12454038
Invest Ophthalmol Vis Sci. 2004 Jan;45(1):153-8
14691167
Exp Eye Res. 2014 Nov;128:114-6
25304217
Arch Ophthalmol. 2011 Mar;129(3):276-81
21402981
Am J Hum Genet. 2012 Feb 10;90(2):331-9
22325362
FASEB J. 2010 Jun;24(6):1700-13
20086048
Br J Ophthalmol. 2010 Oct;94(10):1388-92
20693558
Nature. 2011 Feb 10;470(7333):204-13
21307933
Mol Cell Biol. 2001 Nov;21(22):7707-13
11604506
Invest Ophthalmol Vis Sci. 1995 Feb;36(2):478-89
7843916
Nucleic Acids Res. 2009 Jul;37(13):4181-93
19570852
F1000Prime Rep. 2013 Jun 03;5:17
23755364
Arch Ophthalmol. 1962 Dec;68:742-53
13967694
Nat Rev Mol Cell Biol. 2002 May;3(5):349-63
11988769
Am J Ophthalmol. 1964 Apr;57:543-51
14139296
Indian J Ophthalmol. 2011 Jan;59 Suppl:S97-101
21150042
J Glaucoma. 1995 Jun;4(3):183-8
19920666
Arch Ophthalmol. 2001 Aug;119(8):1171-8
11483085
Invest Ophthalmol Vis Sci. 2014 Jul 15;55(8):4922-33
25028360
Arch Ophthalmol. 2002 Jun;120(6):701-13; discussion 829-30
12049574
J Clin Invest. 2008 Mar;118(3):1056-64
18274669
Invest Ophthalmol Vis Sci. 1998 Dec;39(13):2649-58
9856774
Exp Cell Res. 2014 Oct 1;327(2):171-82
25128150
Ophthalmology. 2010 Jun;117(6):1064-1077.e35
20427088
Nature. 2012 Sep 27;489(7417):519-25
22960745
Ophthalmic Genet. 2015;36(4):299-302
24417561
Eye (Lond). 2005 Jan;19(1):65-71
15105817
Am J Ophthalmol. 1975 Nov;80(5):844-56
1190278
Science. 1976 Dec 24;194(4272):1427-8
1006308
Ophthalmology. 1984 Jun;91(6):564-79
6462622
Endocr Dev. 2013;24:41-56
23392094
Invest Ophthalmol Vis Sci. 1977 Jan;16(1):61-3
832966
Mol Vis. 2003 Sep 05;9:425-39
12963864
J Ocul Pharmacol. 1993 Spring;9(1):35-45
8463731
Cornea. 2015 Aug;34(8):853-8
26020827
Invest Ophthalmol Vis Sci. 1992 Aug;33(9):2672-8
1353486
Invest Ophthalmol. 1972 Oct;11(10):832-7
5071841
Mol Vis. 2013;19:665-74
23559860
J Clin Invest. 2014 May;124(5):1956-65
24691439
PLoS One. 2015 Feb 18;10(2):e0117758
25693195
Gene. 2005 Dec 5;362:70-84
16229975
Exp Eye Res. 2008 Apr;86(4):543-61
18313051
Science. 2001 Aug 10;293(5532):1103-5
11498582
Mol Vis. 2007 Dec 17;13:2282-8
18199969
Invest Ophthalmol Vis Sci. 2002 Oct;43(10):3231-5
12356829
Invest Ophthalmol Vis Sci. 2003 Feb;44(2):473-85
12556371
Nat Rev Genet. 2009 Dec;10(12):872-8
19859063
Arch Ophthalmol. 1963 Oct;70:492-9
14078871
Matrix Biol. 2015 Sep;47:54-65
25960420
Nat Genet. 2014 Oct;46(10):1126-1130
25173106
Br J Ophthalmol. 1968 Jan;52(1):32-9
5635901
Recent Prog Horm Res. 2004;59:333-57
14749509
J Ophthalmol. 2014;2014:750459
24800062
Discov Med. 2011 Aug;12(63):159-67
21878193
Mol Vis. 2007 Apr 27;13:659-66
17563720
Curr Eye Res. 1993 May;12(5):385-96
8344063
Exp Eye Res. 2014 Mar;120:28-35
24374036
Ophthalmic Genet. 2012 Dec;33(4):221-4
22921020
Prog Retin Eye Res. 2015 Jan;44:86-98
25223880
Exp Eye Res. 2015 Mar;132:174-8
25639201
Ophthalmology. 2009 Sep;116(9):1644-50
19643499
Cell Tissue Res. 2012 Jan;347(1):279-90
22101332
PLoS One. 2013;8(3):e58657
23536807
Hum Mol Genet. 1999 May;8(5):899-905
10196380
Clin Biochem. 2006 Mar;39(3):249-58
16332362
Methods Cell Biol. 2007;83:3-27
17613302
Mol Cell Biol. 2004 Oct;24(20):9019-25
15456875
Rheum Dis Clin North Am. 2016 Feb;42(1):15-31, vii
26611548
Am J Ophthalmol. 1951 Nov;34(11):1603-5
14885362
Genomics. 2008 Nov;92(5):255-64
18703132
Fed Proc. 1965 Nov-Dec;24(6):1274-8
5853148