Evaluation of retinal ganglion cell-inner plexiform layer complex in healthy smokers.
OBJECTIVE
To evaluate the effect of smoking on ganglion cell complex and inner plexiform layer (GC-IPL) thickness measured by spectral domain optical coherence tomography (OCT).


METHODS
The right eyes of 36 smoking (study group) and 36 never-smoking (control group) healthy subjects were included in this study. After full ophthalmologic examination, axial length measurement (AL), ganglion cell complex-inner plexiform layer (GC-IPL) thickness, retinal nerve fiber layer (RNFL) thickness, and central macular thickness (CMT) values were measured by OCT. Statistical analysis was performed to compare GC-IPL, RNFL thicknesses, and CMT values between groups.


RESULTS
The mean age [mean ± standard deviation (SD)] of 36 subjects in the study group was 26.2 ± 6.0 years, and the mean age of 36 subjects in control group was 25.7 ± 4.1 years. The mean ALs of the study group and the control group were 22.46 ± 0.88 and 22.36 ± 1.09 mm, respectively (p = 0.68). Mean GC-IPL thickness was 82.8 ± 3 µm in the study group and 84.3 ± 3 µm in the control group (p = 0.08). The mean RNFL values of study and control groups were 95. 8 ± 7.9 and 97. 3 ± 7.8 µm, respectively (p = 0.39). The mean CMT values of study and control groups were 248.3 ± 17.96 and 249.5 ± 17.18 µm, respectively (p = 0.78).


CONCLUSIONS
Smoking does not seem to have any effect on GC-IPL thickness, mean RNFL and CMT values. Further studies in larger groups are needed to reveal the effect of smoking on these parameters.
Sakarya University Educational Research Hospital, 54000, Sakarya, Turkey. b_koklu@yahoo.com.
Burçin
B
Çakır
Sakarya University Educational Research Hospital, 54000, Sakarya, Turkey.
Erkan
E
Çelik
Sakarya University Educational Research Hospital, 54000, Sakarya, Turkey.
Emine
E
Doğan
Sakarya University Educational Research Hospital, 54000, Sakarya, Turkey.
Gürsoy
G
Alagöz
D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D064368:Healthy Volunteers; D006801:Humans; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D009412:Nerve Fibers; D011446:Prospective Studies; D012165:Retinal Ganglion Cells / Q000166:cytology*; D012907:Smoking / Q000009:adverse effects*; D041623:Tomography, Optical Coherence; D055815:Young Adult
Central macular thickness; Ganglion cell complex-inner plexiform layer; Retinal nerve fiber layer; Smoking
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