Synthesis, characterization, anti-bacterial, anti-fungal and nematicidal activities of 2-amino-3-cyanochromenes.
Soil-borne plant pathogens such as nematodes, fungi and some bacteria not only affect the plant cultures but also economy and environmental implications. As a result of these pathogens attacks, the yield and quality of crops is affected. Therefore, synthesis of new compounds to control these pathogens is very important and need of time. Chromenes are considered important group of heterocyclic compounds and exhibited significant biological activities. 2-amino-3-cyano chromenes are considered important medicinal scaffolds among the chromenes. We describe three component microwave assisted synthesis of 2-amino-3-cyano chromenes. The versatility of the reaction was examined by varying the aldehydes in the reaction mixture which lead to the synthesis of series of 2-amino-3-cyanochromenes (1-9). The structural elucidations of the compounds were studied by1H NMR,13C NMR, HRMS and FTIR spectrometer and results were well correlated. The synthesized compounds were evaluated for their anti-bacterial, anti-fungal and nematicidal activities. Among the synthesized compounds, compound 6 showed good anti-bacterial activity while compound 9 exhibited high anti-fungal activity. In case of nematicidal activity, compound 8 indicated high activity as compare with other compounds followed by compound 9. Results indicate that these synthesized compounds could be used as effective control for soil-borne plant pathogens such as nematodes, fungi and bacteria and can help to improve the plant production.
Department of Nano-Medicine Research, Institute for Research and Medical Consultations (IRMC), University of Dammam, Dammam 31441, Saudi Arabia. Electronic address: nawwaz@gmail.com.
Muhammad
M
Nawaz
Department of Botany, University of Karachi, Karachi 75250, Pakistan.
Muhammad Waseem
MW
Abbasi
Department of Chemistry, United Arab Emirates University, Al-Ain 15551, United Arab Emirates.
Soleiman
S
Hisaindee
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D008826:Microbial Sensitivity Tests; D017550:Spectroscopy, Fourier Transform Infrared
D000890:Anti-Infective Agents; D001578:Benzopyrans
Biological activities; Chromenes; Microwave synthesis