RNA Editing Dynamically Rewrites the Cancer Code.
Global analyses of cancer transcriptomes demonstrate that ADAR (adenosine deaminase, RNA-specific)-mediated RNA editing dynamically contributes to genetic alterations in cancer, and directly correlates with progression and prognosis. RNA editing is abundant and frequently elevated in cancer, and affects functionally and clinically relevant sites in both coding and non-coding regions of the transcriptome. Therefore, ADAR and differentially edited transcripts may be promising biomarkers or targets for therapy.
Laboratory of Lymphocyte Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA; The Rockefeller Graduate Program, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Violeta
V
Rayon-Estrada
Laboratory of Lymphocyte Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
F Nina
FN
Papavasiliou
Laboratory of Lymphocyte Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Dewi
D
Harjanto
D006801:Humans; D009154:Mutation; D009369:Neoplasms; D017393:RNA Editing; D016601:RNA-Binding Proteins / Q000235:genetics*; D059467:Transcriptome
D016601:RNA-Binding Proteins
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