Bioactive molecules derived from umbilical cord mesenchymal stem cells.
Umbilical cord mesenchymal stem cells (UCMSCs) retain their intrinsic stem cell potential while at the same time displaying high proliferation rates, powerful differentiation capacity, and low immunogenicity. They can also secrete multiple bioactive molecules that exert specific physiological functions. Thus, UCMSCs represent excellent candidates for cell therapy in regenerative medicine and tissue engineering. Abundant preclinical research on different disease models has shown that UCMSCs can accelerate wound or nerve damage recovery and suppress tumor progression. In fact, UCMSCs are thought to possess a higher therapeutic potential than MSCs derived from other tissues. Increasing evidence suggests that the mechanism underlying UCSMCs efficacy depends mostly on cell secretions, in contrast to the early paradigm of cell replacement and differentiation. In this review, we discuss UCMSCs biological characteristics, their secretome-based therapeutic mechanism, and potential applications.
Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Sichuan Agricultural University, 211 Huimin Road, Wenjiang District, Chengdu, Sichuan 611130, China. Electronic address: bailp1@126.com.
Lipeng
L
Bai
Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Sichuan Agricultural University, 211 Huimin Road, Wenjiang District, Chengdu, Sichuan 611130, China. Electronic address: 272386059@qq.com.
Danting
D
Li
Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Sichuan Agricultural University, 211 Huimin Road, Wenjiang District, Chengdu, Sichuan 611130, China. Electronic address: yx983507581@sina.com.
Jie
J
Li
Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Sichuan Agricultural University, 211 Huimin Road, Wenjiang District, Chengdu, Sichuan 611130, China. Electronic address: zhengzhongluo@163.com.
Zhengzhong
Z
Luo
Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Sichuan Agricultural University, 211 Huimin Road, Wenjiang District, Chengdu, Sichuan 611130, China. Electronic address: yayushumin@163.com.
Shumin
S
Yu
Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Sichuan Agricultural University, 211 Huimin Road, Wenjiang District, Chengdu, Sichuan 611130, China. Electronic address: suizhongcao@126.com.
Suizhong
S
Cao
Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Sichuan Agricultural University, 211 Huimin Road, Wenjiang District, Chengdu, Sichuan 611130, China. Electronic address: shenlh@sicau.edu.cn.
Liuhong
L
Shen
Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Sichuan Agricultural University, 211 Huimin Road, Wenjiang District, Chengdu, Sichuan 611130, China. Electronic address: zzcjl@126.com.
Zhicai
Z
Zuo
Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Sichuan Agricultural University, 211 Huimin Road, Wenjiang District, Chengdu, Sichuan 611130, China. Electronic address: mxp886@sina.com.
Xiaoping
X
Ma
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D002478:Cells, Cultured; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D023822:Tissue Engineering; D014470:Umbilical Cord / Q000166:cytology*
Angiogenesis; Anti-tumor; Cytokine; Immunoregulation; Nerve regeneration; Umbilical cord mesenchymal stem cell