The Dynamics of Functional Brain Networks: Integrated Network States during Cognitive Task Performance.
Higher brain function relies upon the ability to flexibly integrate information across specialized communities of brain regions; however, it is unclear how this mechanism manifests over time. In this study, we used time-resolved network analysis of fMRI data to demonstrate that the human brain traverses between functional states that maximize either segregation into tight-knit communities or integration across otherwise disparate neural regions. Integrated states enable faster and more accurate performance on a cognitive task, and are associated with dilations in pupil diameter, suggesting that ascending neuromodulatory systems may govern the transition between these alternative modes of brain function. Together, our results confirm a direct link between cognitive performance and the dynamic reorganization of the network structure of the brain.
Department of Psychology, Stanford University, Stanford, CA 94305, USA; Neuroscience Research Australia, University of New South Wales, Sydney NSW 2052, Australia. Electronic address: macshine@stanford.edu.
James M
JM
Shine
Department of Psychology, Stanford University, Stanford, CA 94305, USA.
Patrick G
PG
Bissett
University of Queensland Centre for Clinical Research, University of Queensland, Brisbane QLD 4072, Australia.
Peter T
PT
Bell
Department of Psychology, Stanford University, Stanford, CA 94305, USA.
Oluwasanmi
O
Koyejo
Department of Health Sciences and Technology, Neural Control of Movement Laboratory, ETH Zurich, 8092 Zurich, Switzerland.
Joshua H
JH
Balsters
Department of Psychology, Stanford University, Stanford, CA 94305, USA.
Krzysztof J
KJ
Gorgolewski
Department of Psychology, Stanford University, Stanford, CA 94305, USA.
Craig A
CA
Moodie
Department of Psychology, Stanford University, Stanford, CA 94305, USA.
Russell A
RA
Poldrack
D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000502:physiology*; D001931:Brain Mapping; D003071:Cognition / Q000502:physiology*; D005260:Female; D059907:Functional Neuroimaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000502:physiology; D011680:Pupil / Q000502:physiology*; D013647:Task Performance and Analysis
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