Default mode network and frontolimbic gray matter abnormalities in patients with borderline personality disorder: A voxel-based meta-analysis.
Specific frontolimbic abnormalities are hypothesized to underlie the etiology of borderline personality disorder (BPD). However, findings from neuroimaging studies were inconsistent. In the current study, we aimed to provide a complete overview of cerebral microstructural alterations in gray matter (GM) of BPD patients. A total of 11 studies were enrolled, comprising 275 BPD patients and 290 healthy controls (HCs). A meta-analysis was conduct to quantitatively estimate regional GM abnormalities in BPD patients using the seed-based d mapping (SDM). Meta-regression was also conducted. Compared with HCs, the BPD patients exhibited increased GM mainly in bilateral supplementary motor area extending to right posterior cingulated cortex (PCC) and bilateral primary motor cortex, right middle frontal gyrus (MFG), and the bilateral precuneus extending to bilateral PCC. Decreased GM was identified in bilateral middle temporal gyri, right inferior frontal gyrus extending to right insular, left hippocampus and left superior frontal gyrus extending to left medial orbitofrontal cortex. The mean age of BPD patients were found nagativly associated with GM alterations in right MFG. Our findings suggested that BPD patients have significantly GM abnormalities in the default mode network and frontolimbic circuit. Our results provided further evidences in elucidating the underline neural mechanisms of BPD.
School of Sociality and Psychology, Southwest University for Nationalities, Chengdu, China.|Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China.
Xun
X
Yang
School of Sociality and Psychology, Southwest University for Nationalities, Chengdu, China.
Liyuan
L
Hu
School of Accounting, Southwestern University of Finance and Economics, Chengdu, China.
Jianguang
J
Zeng
School of Computer Science and Technology, Southwest University for Nationalities, Chengdu, China.
Ying
Y
Tan
Department of Radiology, West China Second University Hospital, Sichuan University, Chengdu, China.|Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China.
Bochao
B
Cheng
D000328:Adult; D001883:Borderline Personality Disorder / Q000000981:diagnostic imaging / Q000473:pathology*; D016022:Case-Control Studies; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000473:pathology*; D066128:Gray Matter / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008032:Limbic System / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D059906:Neuroimaging
Psychol Med. 2012 Feb;42(2):295-307
21835091
Psychiatry Res. 2013 Aug 30;213(2):83-91
23146251
CNS Spectr. 2012 Jun;17(2):70-5
22789064
J Pers Disord. 2013 Apr;27(2):125-43
23514179
Neuroimage. 2010 Jan 1;49(1):114-20
19660555
Neuropsychologia. 2002;40(6):683-92
11792407
Psychiatry Res. 2015 Jan 30;231(1):25-32
25482858
Biol Psychiatry. 2016 Jan 15;79(2):97-106
25935068
Psychol Med. 2014 Mar;44(4):869-80
23663382
Crim Behav Ment Health. 2009;19(1):64-72
19172640
Curr Psychiatry Rep. 2010 Feb;12(1):61-7
20425312
Biol Psychiatry. 2001 Aug 15;50(4):292-8
11522264
Neuroimage. 2008 Sep 1;42(3):1178-84
18598773
Arch Gen Psychiatry. 2012 Oct;69(10):993-1002
22637967
Am J Psychiatry. 2006 May;163(5):827-32
16648323
Arch Gen Psychiatry. 2000 Dec;57(12):1115-22
11115325
J Psychiatr Res. 2008 Jul;42(9):727-33
17825840
Psychiatry Res. 2004 Jul 30;131(2):125-33
15313519
Hum Brain Mapp. 2003 Jan;18(1):30-41
12454910
Biol Psychiatry. 2003 Jul 15;54(2):163-71
12873806
JAMA. 2000 Apr 19;283(15):2008-12
10789670
Harv Rev Psychiatry. 2013 Sep-Oct;21(5):248-58
24651557
Eur Psychiatry. 2012 Nov;27(8):605-11
21658917
J Psychiatry Neurosci. 2011 Nov;36(6):402-11
21406160
Eur Arch Psychiatry Clin Neurosci. 2013 Oct;263(7):593-606
23381548
Br J Psychiatry. 2009 Nov;195(5):393-402
19880927
J Psychiatry Neurosci. 2013 Mar;38(2):129-37
22909445
J Psychiatr Res. 2012 Apr;46(4):516-25
22336640
Am J Psychiatry. 2009 May;166(5):530-9
19411380
Biol Psychiatry. 2005 Jan 15;57(2):173-82
15652877
Brain Res Brain Res Rev. 1996 Oct;22(3):229-44
8957561
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Nov 13;33(8):1395-400
19632284
JAMA Psychiatry. 2013 Feb;70(2):185-98
23247506
Proc Natl Acad Sci U S A. 2001 Mar 27;98 (7):4259-64
11259662
Neuroimage. 2003 Sep;20(1):385-92
14527598
Psychiatry Res. 2008 Dec 30;164(3):223-36
19019636
Neurosci Biobehav Rev. 2016 Jul;66:92-103
27108216
Psychiatry Res. 2013 Apr 30;206(2-3):273-81
23123044
Biol Psychiatry. 2012 Nov 1;72(9):775-84
22621997
Psychiatry Res. 2007 Nov 15;156(2):139-49
17826965
PLoS One. 2013 Dec 18;8(12):e83677
24367606
Psychiatry Res. 2012 Mar 31;201(3):245-52
22507760
Proc Natl Acad Sci U S A. 2001 Jan 16;98 (2):676-82
11209064
PLoS One. 2013 Jun 12;8(6):e65824
23776553
Biol Psychiatry. 2002 Jun 15;51(12):936-50
12062877
Psychiatry Res. 2013 Jul 30;213(1):1-10
23684978
Behav Neurosci. 1995 Aug;109(4):681-8
7576212
Nat Rev Neurosci. 2005 Jul;6(7):533-44
15995724
Biol Psychiatry. 2012 Sep 15;72(6):448-56
22560044
Psychiatry Res. 2009 May 15;172(2):155-60
19299113
J Clin Psychiatry. 2008 Apr;69(4):533-45
18426259
J Psychiatry Neurosci. 2009 Sep;34(5):383-8
19721849
Biol Psychiatry. 2010 Aug 15;68(4):383-91
20537612
Cereb Cortex. 2001 Jan;11(1):17-25
11113032
Neuropsychopharmacology. 2011 Jun;36(7):1466-77
21430645
Neuroimage. 2001 Dec;14(6):1238-43
11707080