Probing and rearranging the transcription factor network controlling theC. elegansendoderm.
The ELT-2 GATA factor is the predominant transcription factor regulating gene expression in theC. elegansintestine, following endoderm specification. We comment on our previous study (Wiesenfahrtet al., 2016) that investigated how theelt-2gene is controlled by END-1, END-3 and ELT-7, the 3 endoderm specific GATA factors that lie upstream in the regulatory hierarchy. We also discuss the unexpected result that ELT-2, if expressed sufficiently early and at sufficiently high levels, can specify theC. elegansendoderm, replacing the normal functions of END-1 and END-3.
Department of Biochemistry and Molecular Biology, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary , Calgary, AB, Canada.
Tobias
T
Wiesenfahrt
Department of Biochemistry and Molecular Biology, Colorado State University , Fort Collins, CO, USA.
Erin
E
Osborne Nishimura
Department of Biochemistry and Molecular Biology, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary , Calgary, AB, Canada.
Janette Y
JY
Berg
Department of Biochemistry and Molecular Biology, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary , Calgary, AB, Canada.
James D
JD
McGhee
C. elegans; ELT-2; ELT-7; END-1; END-3; GATA factor; gene regulation; intestine; transcription
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