Ocular adnexal marginal zone lymphoma arising in a patient with IgG4-related ophthalmic disease.
A 41-year-old man was diagnosed with immunoglobulin G4-related disease (IgG4-RD) in both eyelids 4 years ago and exhibited good response to steroid therapy. However, rapid swelling of the right eyelid lesion was recently observed. As IgG4-RD progression was suspected, biopsy was performed. Although the histology was consistent with IgG4-RD, the infiltrating large atypical lymphoid cells showed immunoglobulin light-chain restriction and IgH gene rearrangement. Consequently, he was diagnosed with extranodal marginal zone lymphoma with abundant IgG4-positive cells.
a Department of Pathology , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan.
Kenji
K
Nishida
b Department of Ophthalmology , Mitoyo General Hospital , Kan-Onji , Japan.
Yuka
Y
Sogabe
c Department of Dermatology , Mitoyo General Hospital , Kan-Onji , Japan.
Ayako
A
Makihara
c Department of Dermatology , Mitoyo General Hospital , Kan-Onji , Japan.
Akemi
A
Senoo
d Department of Internal Medicine , Mitoyo General Hospital , Kan-Onji , Japan , and.
Hisanori
H
Morimoto
a Department of Pathology , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan.
Mai
M
Takeuchi
a Department of Pathology , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan.
Yuka
Y
Gion
a Department of Pathology , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan.
Tadashi
T
Yoshino
a Department of Pathology , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan.|e Division of Pathophysiology , Okayama University Graduate School of Health Sciences , Okayama , Japan.
Yasuharu
Y
Sato
D000328:Adult; D001706:Biopsy / Q000379:methods; D003937:Diagnosis, Differential; D005134:Eye Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D005143:Eyelids / Q000473:pathology*; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D000077733:Immunoglobulin G4-Related Disease / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D008297:Male; D015513:Oncogene Proteins
D005938:Glucocorticoids; D007074:Immunoglobulin G; D015513:Oncogene Proteins
IgG4-related disease; marginal zone lymphoma; ocular adnexa