Amniopatch treatment of iatrogenic preterm premature rupture of membranes (iPPROM) after fetoscopic laser surgery for twin-twin transfusion syndrome.
OBJECTIVE
Amniopatch is a proposed treatment of iatrogenic preterm premature rupture of membranes (iPPROM). We studied characteristics associated with successful amniopatch treatment of iPPROM after fetoscopic laser surgery for twin-twin transfusion syndrome.


METHODS
Patients with iPPROM within 15 days of laser surgery treated with an amniopatch were studied. Factors associated with amniopatch success (i.e. cessation of leakage with normalization of amniotic fluid volume) were tested univariately and in multivariate logistic regression models. Continuous variables are expressed as median (range).


RESULTS
Of 1124 patients undergoing laser surgery, 19 (1.7%) had iPPROM and subsequent amniopatch. Twelve (63.2%) were successful. Latency in days from iPPROM to delivery was greater in the successful group (114.0 [87.0-141.0]) versus (44.0 [3.9-88.0], p = 0.0005), which translated into greater gestational age (GA) (weeks) at delivery (35.1 [30.9-39.4] versus 28.1 [22.0-31.0], p = 0.0005). The 30-day survival of the affected recipient twin was improved (100% versus 57.1%, p = 0.0361). After multivariate testing, GA < 20 weeks at the time of the amniopatch placement was the only variable that remained associated with successful sealing of the membranes.


CONCLUSIONS
Treatment of iPPROM via amniopatch was successful in almost two-thirds of cases and was associated with higher GA at delivery and improved perinatal survival.
a Department of Obstetrics and Gynecology , Division of Maternal-Fetal Medicine, Keck School of Medicine, University of Southern California , Los Angeles , CA , USA.
Ramen H
RH
Chmait
b Department of Obstetrics and Gynecology , Division of Maternal-Fetal Medicine, University of Missouri-Kansas City School of Medicine, Children's Mercy Hospital , Kansas City , MO , USA , and.
Eftichia V
EV
Kontopoulos
a Department of Obstetrics and Gynecology , Division of Maternal-Fetal Medicine, Keck School of Medicine, University of Southern California , Los Angeles , CA , USA.
Andrew H
AH
Chon
c Childbirth Research Associates , North Hollywood , CA , USA.
Lisa M
LM
Korst
a Department of Obstetrics and Gynecology , Division of Maternal-Fetal Medicine, Keck School of Medicine, University of Southern California , Los Angeles , CA , USA.
Arlyn
A
Llanes
b Department of Obstetrics and Gynecology , Division of Maternal-Fetal Medicine, University of Missouri-Kansas City School of Medicine, Children's Mercy Hospital , Kansas City , MO , USA , and.
Rubén A
RA
Quintero
D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000601:surgery*; D005330:Fetofetal Transfusion / Q000601:surgery*; D005332:Fetoscopy / Q000009:adverse effects*; D005865:Gestational Age; D006801:Humans; D007049:Iatrogenic Disease; D007231:Infant, Newborn; D053685:Laser Therapy / Q000009:adverse effects*; D016015:Logistic Models; D011247:Pregnancy; D011256:Pregnancy Outcome; D059285:Pregnancy, Twin; D012189:Retrospective Studies; D012307:Risk Factors
Fetal membrane patch; amniopatch; fetal membrane repair; fetal membrane sealant