In-vivo, non-invasive detection of hyperglycemic states in animal models using mm-wave spectroscopy.
Chronic or sustained hyperglycemia associated to diabetes mellitus leads to many medical complications, thus, it is necessary to track the evolution of patients for providing the adequate management of the disease that is required for the restoration of the carbohydrate metabolism to a normal state. In this paper, a novel monitoring approach based on mm-wave spectroscopy is comprehensively described and experimentally validated using living animal models as target. The measurement method has proved the possibility of non-invasive, in-vivo, detection of hyperglycemia-associated conditions in different mouse models, making possible to clearly differentiate between several hyperglycemic states.
Department of Electronics Technology, Universidad Carlos III de Madrid, Leganes, Madrid 28911, Spain.
Pedro
P
Martín-Mateos
Physics Institute, Goethe University Frankfurt am Main, 60438 Frankfurt am Main, Germany.
Fabian
F
Dornuf
Epithelial Biomedicine Division, CIEMAT, Avenida Complutense 40, Madrid, 28040, Spain.|Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain.
Blanca
B
Duarte
Physics Institute, Goethe University Frankfurt am Main, 60438 Frankfurt am Main, Germany.
Bernhard
B
Hils
Department of Electronics Technology, Universidad Carlos III de Madrid, Leganes, Madrid 28911, Spain.
Aldo
A
Moreno-Oyervides
Department of Electronics Technology, Universidad Carlos III de Madrid, Leganes, Madrid 28911, Spain.
Oscar Elias
OE
Bonilla-Manrique
Epithelial Biomedicine Division, CIEMAT, Avenida Complutense 40, Madrid, 28040, Spain.|Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain.|Department of Bioengineering, Universidad Carlos III de Madrid, Leganes, Madrid 28911, Spain.|Instituto de Investigaciones sanitarias de la Fundación Jimenez Diaz (IIS-FJD), Madrid, Spain.
Fernando
F
Larcher
Physics Institute, Goethe University Frankfurt am Main, 60438 Frankfurt am Main, Germany.
Viktor
V
Krozer
Department of Electronics Technology, Universidad Carlos III de Madrid, Leganes, Madrid 28911, Spain.
Pablo
P
Acedo
Diabetes. 2009 Dec;58(12):2893-903
19720799
Sci Rep. 2016 Jan 28;6:20028
26818011
Ann Intern Med. 1984 Oct;101(4):527-37
6383165
PLoS One. 2013;8(3):e57762
23469230
Korean J Physiol Pharmacol. 2014 Feb;18(1):1-14
24634591
J Periodontol. 2008 Nov;79(11):2190-9
18980529
Dermatoendocrinol. 2012 Jul 1;4(3):259-70
23467327
Clin Chem. 1998 Sep;44(9):1951-8
9732983
J Diabetes Sci Technol. 2009 Jul 01;3(4):629-34
20144304
Nat Rev Neurol. 2010 Mar;6(3):145-55
20157308
Clin Med (Lond). 2012 Dec;12(6):568-71
23342412
Biomed Opt Express. 2014 Aug 28;5(9):3231-7
25401034
Diabetes Care. 2008 Feb;31 Suppl 2:S155-60
18227478
J Diabetes Sci Technol. 2008 Nov;2(6):1114-21
19885300
Biochim Biophys Acta. 2013 Dec;1830(12):5509-14
23673238
Diabetes. 2005 Jun;54(6):1615-25
15919781