Novel adipokines WISP1 and betatrophin in PCOS: relationship to AMH levels, atherogenic and metabolic profile.
OBJECTIVE
To determine the levels of WISP1 and betatrophin in normal weight and obese women with polycystic ovary syndrome (PCOS) and to assess their relationship with anti-Müllerian hormone (AMH) levels, atherogenic profile and metabolic parameters Methods: In this prospective cross-sectional study, the study group was composed of 49 normal weighed and 34 obese women with PCOS diagnosed based on the Rotterdam criteria; 36 normal weight and 26 obese age matched non-hyperandrogenemic women with regular menstrual cycle. Serum WISP1, betatrophin, homeostasis model assessment of insulin resistance (HOMA-IR) and AMH levels were evaluated. Univariate and multivariate analyses were performed between betatrophin, WISP1 levels and AMH levels, metabolic and atherogenic parameters.


RESULTS
Serum WISP1 and betatrophin values were elevated in the PCOS group than in the control group. Moreover, serum WISP1 and betatrophin levels were higher in the obese PCOS subgroup than in normal weight and obese control subgroups. Multivariate analyses revealed that Body mass index, HOMA-IR, AMH independently and positively predicted WISP1 levels. Serum betatrophin level variability was explained by homocysteine, HOMA-IR and androstenedione levels.


CONCLUSIONS
WISP1 and betatrophin may play a key role on the pathogenesis of PCOS.
a Department of Obstetrics and Gynecology , Kartal Dr. Lutfi Kirdar Education and Research Hospital , Istanbul , Turkey.
Gulcin
G
Sahin Ersoy
b Department of Obstetrics and Gynecology , Etlik Zubeyde Hanim Women's Health Education and Research Hospital , Ankara , Turkey.
Tugba
T
Altun Ensari
a Department of Obstetrics and Gynecology , Kartal Dr. Lutfi Kirdar Education and Research Hospital , Istanbul , Turkey.
Dogan
D
Vatansever
c Department of Obstetrics and Gynecology , Izmir University , Izmir , Turkey , and.
Volkan
V
Emirdar
d Department of Biochemistry , Faculty of Pharmacy, Cumhuriyet University , Sivas , Turkey.
Ozge
O
Cevik
D000328:Adult; D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D054304:Anti-Mullerian Hormone / Q000097:blood*; D055511:CCN Intercellular Signaling Proteins / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D009765:Obesity / Q000097:blood*; D036361:Peptide Hormones / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D011446:Prospective Studies; D011518:Proto-Oncogene Proteins / Q000097:blood*; D055815:Young Adult
C576683:ANGPTL8 protein, human; D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D055511:CCN Intercellular Signaling Proteins; C116396:CCN4 protein, human; D036361:Peptide Hormones; D011518:Proto-Oncogene Proteins; D054304:Anti-Mullerian Hormone
AMH; WISP1; betatrophin; insulin resistance; polycystic ovary syndrome