Genome-wide DNA methylation in 1-year-old infants of mothers with major depressive disorder.
A genome-wide methylation study was conducted among a sample of 114 infants (M age = 13.2 months, SD = 1.08) of low-income urban women with (n = 73) and without (n = 41) major depressive disorder. The Illumina HumanMethylation450 BeadChip array with a GenomeStudio Methylation Module and Illumina Custom model were used to conduct differential methylation analyses. Using the 5.0 × 10-7 p value, 2,119 loci were found to be significantly different between infants of depressed and nondepressed mothers. Infants of depressed mothers had greater methylation at low methylation sites (0%-29%) compared to infants of nondepressed mothers. At high levels of methylation (70%-100%), the infants of depressed mothers were predominantly hypomethylated. The mean difference in methylation between the infants of depressed and infants of nondepressed mothers was 5.23%. Disease by biomarker analyses were also conducted using GeneGo MetaCore Software. The results indicated significant cancer-related differences in biomarker networks such as prostatic neoplasms, ovarian and breast neoplasms, and colonic neoplasms. The results of a process networks analysis indicated significant differences in process networks associated with neuronal development and central nervous system functioning, as well as cardiac development between infants of depressed and nondepressed mothers. These findings indicate that early in development, infants of mothers with major depressive disorder evince epigenetic differences relative to infants of well mothers that suggest risk for later adverse health outcomes.
University of Minnesota Institute of Child Development.
Dante
D
Cicchetti
University of Minnesota Institute of Child Development.
Susan
S
Hetzel
University of Rochester Mt. Hope Family Center.
Fred A
FA
Rogosch
University of Rochester Mt. Hope Family Center.
Elizabeth D
ED
Handley
University of Rochester Mt. Hope Family Center.
Sheree L
SL
Toth
D000328:Adult; D016241:Child of Impaired Parents; D019175:DNA Methylation; D003865:Major Depressive Disorder; D044127:Epigenesis, Genetic; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009035:Mothers; D055815:Young Adult
Child Dev. 2013 Jan-Feb;84(1):49-57
22880724
Arch Gen Psychiatry. 1981 Apr;38(4):381-9
6260053
J Exp Child Psychol. 1997 Dec;67(3):338-62
9440297
Psychol Med. 1982 Nov;12(4):855-70
7156256
Nat Rev Genet. 2011 Jul 12;12(8):529-41
21747404
Epigenetics. 2008 Mar-Apr;3(2):97-106
18536531
J Consult Clin Psychol. 2006 Dec;74(6):1006-16
17154731
Int J Neurosci. 2008 Aug;118(8):1081-108
18576209
Epigenetics. 2015;10(5):408-17
25875334
Depress Anxiety. 2004;19(3):187-9
15129421
Am J Prev Med. 2013 Feb;44(2):101-7
23332324
Science. 1982 Dec 17;218(4578):1235-7
7146906
Child Dev. 1985 Aug;56(4):884-93
4042751
Child Dev Perspect. 2008 Dec;2(3):141-148
19956783
Psychol Rev. 1999 Jul;106(3):458-90
10467895
Am Psychol. 1998 Feb;53(2):221-41
9491749