Protective Effects of Sporoderm-Broken Spores of Ganderma lucidum on Growth Performance, Antioxidant Capacity and Immune Function of Broiler Chickens Exposed to Low Level of Aflatoxin B₁.
This study was conducted to investigate the toxic effects of aflatoxin B₁ (AFB₁) and evaluate the effects of sporoderm-broken spores of Ganoderma lucidum (SSGL) in relieving aflatoxicosis in broilers. A total of 300 one-day-old male Arbor Acre broiler chickens were randomly divided into four dietary treatments; the treatment diets were: Control (a basal diet containing normal peanut meal); AFB₁ (the basal diet containing AFB₁-contaminated peanut meal); SSGL (basal diet with 200 mg/kg of SSGL); AFB₁+SSGL (supplementation of 200 mg/kg of SSGL in AFB₁ diet). The contents of AFB₁ in AFB₁ and AFB₁+SSGL diets were 25.0 μg/kg in the starter period and 22.5 μg/kg in the finisher period. The results showed that diet contaminated with a low level of AFB₁ significantly decreased (p < 0.05) the average daily feed intake and average daily gain during the entire experiment and reduced (p < 0.05) serum contents of total protein IgA and IgG. Furthermore, a dietary low level of AFB₁ not only increased (p < 0.05) levels of hydrogen peroxide and lipid peroxidation, but also decreased (p < 0.05) total antioxidant capability, catalase, glutathione peroxidase, and hydroxyl radical scavenger activity in the liver and spleen of broilers. Moreover, the addition of SSGL to AFB₁-contaminated diet counteracted these negative effects, indicating that SSGL has a protective effect against aflatoxicosis.
State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China. liuyitao2004@126.com.
Tao
T
Liu
State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China. maqiugang@cau.edu.cn.
Qiugang
Q
Ma
State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China. lihongzhao100@126.com.
Lihong
L
Zhao
College of Life Science, Shanxi University, Taiyuan 030006, Shanxi, China. jiaru.bjdk071@163.com.
Ru
R
Jia
State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China. jyzhang@cau.edu.cn.
Jianyun
J
Zhang
State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China. jicheng@cau.edu.cn.
Cheng
C
Ji
State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China. xinyuewang2016@126.com.
Xinyue
X
Wang
D016604:Aflatoxin B1 / Q000633:toxicity*; D000821:Animal Feed; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D002645:Chickens; D005506:Food Contamination; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D020940:Reishi; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D013170:Spores; D013482:Superoxide Dismutase / Q000378:metabolism
D001798:Blood Proteins; D008315:Malondialdehyde; D016604:Aflatoxin B1; D006861:Hydrogen Peroxide; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005978:Glutathione
aflatoxins; antioxidant capability; oxidative stress; spores of Ganoderma lucidum
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