Nuchal Skinfold Thickness: A Novel Parameter for Assessment of Body Composition in Childhood Craniopharyngioma.
Hypothalamic obesity, cardiovascular disease (CVD), and relapse/progression have a major impact on prognosis in childhood-onset craniopharyngioma (CP). We analyzed nuchal skinfold thickness (NST) on magnetic resonance imaging performed for follow-up monitoring as a novel parameter for body composition (BC) and CVD in CP.



The objective of the study was to identify the association of NST with body mass index (BMI), waist to height ratio (WHtR), functional capacity, and blood pressure (BP) in CP and controls.



This was a cross-sectional and longitudinal prospective study in CP patients.



The study was conducted at HIT-Endo, KRANIOPHARYNGEOM 2000/2007.



Participants included 94 CP patients and 75 controls.



There were no interventions.



Association of NST with BC and BP in 43 CP and 43 controls was measured.



NST correlated with BMI SD score (SDS; r = 0.78; P < .001; n = 169) and WHtR (r = 0.85; P < .001; n = 86) in the total cohort and CP patients (NST-BMI SDS: r = 0.77, P < .001, n = 94); NST-WHtR: r = 0.835, P < .001, n=43) and controls (NST-BMI SDS: r = 0.792, P < .001, n = 75; NST-WHtR: r = 0.671, P < .001, n = 43). In CP, systolic BP correlated with NST (r = 0.575, P < .001), BMI SDS (r = 0.434, P = .004), and WHtR (r = 0.386, P = .011). Similar results were observed for diastolic BP in CP. In multivariate analyses, NST had a predictive value for hypertension in postpubertal CP and controls (odds ratio 6.98, 95% confidence interval [1.65, 29.5], P = .008). During a longitudinal follow-up, changes in NST correlated with changes in BMI SDS (P < .001) and WHtR (P = .01) but not with changes in BP and functional capacity.



Because monitoring of magnetic resonance imaging and BC is essential for follow-up in CP, NST could serve as a novel and clinically relevant parameter for longitudinal assessment of BC and CVD risk in CP.
Department of Pediatrics (A.S.S., A.H., J.R., K.L., H.L.M.), Klinikum Oldenburg AöR, Medical Campus University Oldenburg, 26133 Oldenburg, Germany; University of Groningen (A.S.S.), 9700 Groningen, The Netherlands; Institute of Biostatistics and Clinical Research (M.E.), University of Münster, 48149 Münster, Germany; and Department of Neuroradiology (M.W.-M.), University Hospital, 97080 Würzburg, Germany.
Anthe S
AS
Sterkenburg
Department of Pediatrics (A.S.S., A.H., J.R., K.L., H.L.M.), Klinikum Oldenburg AöR, Medical Campus University Oldenburg, 26133 Oldenburg, Germany; University of Groningen (A.S.S.), 9700 Groningen, The Netherlands; Institute of Biostatistics and Clinical Research (M.E.), University of Münster, 48149 Münster, Germany; and Department of Neuroradiology (M.W.-M.), University Hospital, 97080 Würzburg, Germany.
Anika
A
Hoffmann
Department of Pediatrics (A.S.S., A.H., J.R., K.L., H.L.M.), Klinikum Oldenburg AöR, Medical Campus University Oldenburg, 26133 Oldenburg, Germany; University of Groningen (A.S.S.), 9700 Groningen, The Netherlands; Institute of Biostatistics and Clinical Research (M.E.), University of Münster, 48149 Münster, Germany; and Department of Neuroradiology (M.W.-M.), University Hospital, 97080 Würzburg, Germany.
Julia
J
Reichel
Department of Pediatrics (A.S.S., A.H., J.R., K.L., H.L.M.), Klinikum Oldenburg AöR, Medical Campus University Oldenburg, 26133 Oldenburg, Germany; University of Groningen (A.S.S.), 9700 Groningen, The Netherlands; Institute of Biostatistics and Clinical Research (M.E.), University of Münster, 48149 Münster, Germany; and Department of Neuroradiology (M.W.-M.), University Hospital, 97080 Würzburg, Germany.
Kristin
K
Lohle
Department of Pediatrics (A.S.S., A.H., J.R., K.L., H.L.M.), Klinikum Oldenburg AöR, Medical Campus University Oldenburg, 26133 Oldenburg, Germany; University of Groningen (A.S.S.), 9700 Groningen, The Netherlands; Institute of Biostatistics and Clinical Research (M.E.), University of Münster, 48149 Münster, Germany; and Department of Neuroradiology (M.W.-M.), University Hospital, 97080 Würzburg, Germany.
Maria
M
Eveslage
Department of Pediatrics (A.S.S., A.H., J.R., K.L., H.L.M.), Klinikum Oldenburg AöR, Medical Campus University Oldenburg, 26133 Oldenburg, Germany; University of Groningen (A.S.S.), 9700 Groningen, The Netherlands; Institute of Biostatistics and Clinical Research (M.E.), University of Münster, 48149 Münster, Germany; and Department of Neuroradiology (M.W.-M.), University Hospital, 97080 Würzburg, Germany.
Monika
M
Warmuth-Metz
Department of Pediatrics (A.S.S., A.H., J.R., K.L., H.L.M.), Klinikum Oldenburg AöR, Medical Campus University Oldenburg, 26133 Oldenburg, Germany; University of Groningen (A.S.S.), 9700 Groningen, The Netherlands; Institute of Biostatistics and Clinical Research (M.E.), University of Münster, 48149 Münster, Germany; and Department of Neuroradiology (M.W.-M.), University Hospital, 97080 Würzburg, Germany.
Hermann L
HL
Müller
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001794:Blood Pressure / Q000502:physiology*; D001823:Body Composition / Q000502:physiology*; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D003397:Craniopharyngioma / Q000150:complications*; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009333:Neck / Q000000981:diagnostic imaging*; D010911:Pituitary Neoplasms / Q000150:complications*; D012042:Registries; D012306:Risk; D012885:Skinfold Thickness; D065927:Waist-Height Ratio; D055815:Young Adult
Curr Opin Endocrinol Diabetes Obes. 2016 Feb;23(1):81-9
26574645
Neuro Oncol. 2013 Jun;15(6):767-74
23486689
Helv Paediatr Acta Suppl. 1989 Jun;52:1-125
2737921
Eur J Clin Nutr. 1991 Jan;45(1):13-21
1855495
N Engl J Med. 1992 Nov 5;327(19):1350-5
1406836
Klin Padiatr. 1996 Sep-Oct;208(5):294-8
8992097
Endocr Rev. 2014 Jun;35(3):513-43
24467716
Diabetes Metab Syndr Obes. 2013 Oct 24;6:403-19
24179379
Diabetes Res Clin Pract. 1994 Oct;24 Suppl:S111-6
7859591
Rev Paul Pediatr. 2014 Jun;32(2):221-9
25119754
BMJ. 1995 Feb 18;310(6977):446
7873953
Int J Obes (Lond). 2006 Apr;30(4):598-602
16570089
J Clin Endocrinol Metab. 2014 Nov;99(11):3972-7
25077898
Arch Intern Med. 2005 Apr 11;165(7):777-83
15824297
N Engl J Med. 2007 Dec 6;357(23):2329-37
18057335
J Clin Endocrinol Metab. 2010 Aug;95(8):3701-10
20484490
Int J Obes (Lond). 2010 May;34(5):791-9
20125098
J Clin Invest. 2004 Jun;113(11):1582-8
15173884
Curr Opin Endocrinol Diabetes Obes. 2014 Oct;21(5):345-51
25106000
Swiss Med Wkly. 2011 Jul 01;141:w13227
21720967
Exp Clin Cardiol. 2006 Spring;11(1):14-20
18651013
Int J Obes Relat Metab Disord. 2000 Nov;24(11):1453-8
11126342
Klin Padiatr. 2014 May;226(3):161-8
24819386
Int J Obes (Lond). 2006 Jan;30(1):23-30
16344845
Arch Dis Child. 1970 Feb;45(239):13-23
5440182
PLoS One. 2014 Mar 13;9(3):e91586
24626110
J Clin Endocrinol Metab. 2011 Jul;96(7):1981-91
21508127
Neuro Oncol. 2015 Jul;17(7):1029-38
25838139
Circulation. 2007 Jul 3;116(1):39-48
17576866
Am J Clin Nutr. 2008 Sep;88(3):645-50
18779279
Int J Obes Relat Metab Disord. 2003 May;27(5):610-6
12704405
Obes Facts. 2013;6(2):165-75
23594424
Int J Obes Relat Metab Disord. 2002 Jun;26(6):873-5
12037660
Pediatr Diabetes. 2013 Dec;14(8):575-84
23710887
Klin Padiatr. 2001 Jul-Aug;213(4):244-9
11528558
Pituitary. 2013 Mar;16(1):46-55
22961634
Obes Res. 2003 Feb;11(2):226-31
12582218
J Pediatr Endocrinol Metab. 2015 Jan;28(1-2):35-43
25503864
Obesity (Silver Spring). 2007 Mar;15(3):748-52
17372326
Obes Facts. 2011;4(5):379-85
22166758