Fluency tasks generate beta-gamma activity in language-related cortical areas of patients during stereo-EEG monitoring.
A quantitative method was developed to map cortical areas responsive to cognitive tasks during intracerebral stereo-EEG recording sessions in drug-resistant patients candidate for epilepsy surgery. Frequency power changes were evaluated with a computer-assisted analysis in 7 patients during phonemic fluency tasks. All patients were right-handed and were explored with depth electrodes in the dominant frontal lobe. We demonstrate that fluency tasks enhance beta-gamma frequencies and reduce background activities in language network regions of the dominant hemisphere. Non-reproducible changes were observed in other explored brain areas during cognitive tests execution.
Unit of Epileptology and Experimental Neurophysiology, Fondazione Istituto Neurologico Carlo Besta, Milano, Italy.
Chiara
C
Pastori
Claudio Munari Epilepsy Surgery Center, Ospedale Niguarda, Milano, Italy.
Stefano
S
Francione
Claudio Munari Epilepsy Surgery Center, Ospedale Niguarda, Milano, Italy.
Federica
F
Pelle
Unit of Epileptology and Experimental Neurophysiology, Fondazione Istituto Neurologico Carlo Besta, Milano, Italy.
Marco
M
de Curtis
Unit of Epileptology and Experimental Neurophysiology, Fondazione Istituto Neurologico Carlo Besta, Milano, Italy. Electronic address: gnatkovsky@istituto-besta.it.
Vadym
V
Gnatkovsky
D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D065711:Broca Area / Q000502:physiology; D002540:Cerebral Cortex / Q000502:physiology*; D004569:Electroencephalography; D004827:Epilepsy / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D005625:Frontal Lobe / Q000502:physiology; D006801:Humans; D007802:Language; D008297:Male
Beta-gamma activity; Epilepsy surgery; Fluency tasks; Intracranial EEG; Stereo-EEG