Effects of breast density and compression on normal breast tissue hemodynamics through breast tomosynthesis guided near-infrared spectral tomography.
Optically derived tissue properties across a range of breast densities and the effects of breast compression on estimates of hemoglobin, oxygen metabolism, and water and lipid concentrations were obtained from a coregistered imaging system that integrates near-infrared spectral tomography (NIRST) with digital breast tomosynthesis (DBT). Image data were analyzed from 27 women who underwent four IRB approved NIRST/DBT exams that included fully and mildly compressed breast acquisitions in two projections—craniocaudal (CC) and mediolateral-oblique (MLO)—and generated four data sets per patient (full and moderate compression in CC and MLO views). Breast density was correlated with HbT (r=0.64, p=0.001), water (r=0.62, p=0.003), and lipid concentrations (r=?0.74, p<0.001), but not oxygen saturation. CC and MLO views were correlated for individual subjects and demonstrated no statistically significant differences in grouped analysis. Comparison of compressed and uncompressed imaging demonstrated a significant decrease in oxygen saturation under compression (58% versus 50%, p=0.04). Mammographic breast density categorization was correlated with measured optically derived properties.
Dartmouth College, Thayer School of Engineering, 14 Engineering Drive, Hanover, New Hampshire 03755, United States.
Kelly E
KE
Michaelsen
Dartmouth College, Thayer School of Engineering, 14 Engineering Drive, Hanover, New Hampshire 03755, United States.
Venkataramanan
V
Krishnaswamy
Georgia Institute of Technology, School of Mechanical Engineering, 801 Ferst Drive, Atlanta, Georgia 30332, United States.
Linxi
L
Shi
University of Massachusetts Medical School, Department of Radiology, 55 Lake Avenue North, Worcester, Massachusetts 01655, United States.
Srinivasan
S
Vedantham
University of Massachusetts Medical School, Department of Radiology, 55 Lake Avenue North, Worcester, Massachusetts 01655, United States.
Andrew
A
Karellas
Dartmouth College, Thayer School of Engineering, 14 Engineering Drive, Hanover, New Hampshire 03755, United States.
Brian W
BW
Pogue
Dartmouth College, Thayer School of Engineering, 14 Engineering Drive, Hanover, New Hampshire 03755, United States.
Keith D
KD
Paulsen
Washington University School of Medicine, Mallinckrodt Institute of Radiology, 4921 Parkview Place, St. Louis, Missouri 63110, United States.
Steven P
SP
Poplack
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