The Effect of Aluminum Exposure on Reproductive Ability in the Bank Vole (Myodes glareolus).
Human impact on the environment is steadily increasing the amounts of aluminum in the ecosystems. This element accumulates in plants and water, potentially exposing herbivores to its harmful effect. In heavily polluted sites, a decrease in the density of small rodent populations has been observed. This decline may be caused by many factors, including decreased fertility. The aim of the presented research was to determine how aluminum, administered at concentrations similar to those recorded in industrial districts (Al I = 3 mg/l, Al II = 200 mg/l), affects the reproductive abilities of small rodents. As the indicators of reproductive abilities, body weight, weight of the testes and accessory sex glands of males, and uterus weight of females were estimated. In females, the number of matured follicles (types 6, 7, and 8) was analyzed, while in males, the quantity and quality (matured, viable, swollen, motile, head abnormalities) of epididymal sperm cells were assessed. Moreover, the development of testes, measured by spermatogenic index, was determined. The model species was the bank vole. Our results have proven that aluminum impairs adult individuals' reproductive abilities by decreasing the quality and quantity of sperm cells and by causing morphologically abnormal development of the gonads. However, no difference in male organometric parameters was found, and only in females treated with 3 mg/l Al, the uterus weight was higher than control. No differences were found in the total number of matured follicles. These results suggest that the decline in rodent numbers in industrial districts is due, at least in part, to poorer males' reproductive abilities, resulting from exposure to aluminum contamination.
Institute of Environmental Sciences, Jagiellonian University, Gronostajowa 7, 30-387, Kraków, Poland. agata.miska.schramm@gmail.com.
Agata
A
Miska-Schramm
Institute of Environmental Sciences, Jagiellonian University, Gronostajowa 7, 30-387, Kraków, Poland.
Joanna
J
Kapusta
Institute of Environmental Sciences, Jagiellonian University, Gronostajowa 7, 30-387, Kraków, Poland.
Małgorzata
M
Kruczek
D000535:Aluminum / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D003411:Arvicolinae / Q000502:physiology*; D001835:Body Weight / Q000187:drug effects; D005260:Female; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000187:drug effects* / Q000473:pathology; D012098:Reproduction / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects* / Q000473:pathology; D013737:Testis / Q000187:drug effects* / Q000473:pathology
D000535:Aluminum
Aluminum; Bank vole; Ovarian follicles; Sperm cells; Spermatozoa
Cell Mol Life Sci. 2005 Jan;62(2):143-58
15666086
Toxicol Sci. 2001 Nov;64(1):77-82
11606803
Hum Reprod. 1998 Jan;13(1):115-9
9512240
Physiol Behav. 1986 Jan;36(1):63-7
3952185
Biol Trace Elem Res. 1996 May;52(2):181-92
8773759
J Hepatol. 2013 Oct;59(4):797-804
23714156
N Engl J Med. 1997 May 29;336(22):1557-61
9164811
Arch Toxicol. 2008 Nov;82(11):789-802
18668223
J Toxicol Environ Health B Crit Rev. 2007;10 Suppl 1:1-269
18085482
Tree Physiol. 2002 Aug;22(11):785-92
12184982
Biol Trace Elem Res. 2009 Oct;131(1):13-24
19242659
Arch Environ Contam Toxicol. 2011 Apr;60(3):524-32
20532880
Toxicology. 2007 Oct 8;239(3):213-23
17714845
J Trace Elem Med Biol. 2007;21 Suppl 1:31-4
18039493
Arch Environ Contam Toxicol. 2014 Jan;66(1):139-53
23903382
Chemosphere. 2007 Jun;68(5):951-7
17335869
Neurosci Lett. 1994 Jan 17;166(1):89-92
8190365
Environ Toxicol Pharmacol. 2001 Jun;10(1-2):53-60
11382556
J Reprod Fertil. 1968 Dec;17(3):555-7
5715685
Acta Vet Scand. 2010 Nov 05;52:58
21054852
Indian J Med Res. 2008 Oct;128(4):545-56
19106446
J Reprod Fertil. 1979 Mar;55(2):423-7
374729
Proc Soc Exp Biol Med. 1997 Oct;216(1):81-5
9316614
Environ Res. 2002 Jun;89(2):101-15
12123643
Fundam Appl Toxicol. 1995 Apr;25(1):45-51
7601326
Proc Biol Sci. 2001 Mar 22;268(1467):661-6
11297185
Biol Trace Elem Res. 1998 Summer;64(1-3):215-9
9845475
Physiol Behav. 2008 Jul 5;94(4):611-5
18495182
Life Sci. 1996;58(17):1387-95
8622564
Life Sci. 2014 Mar 28;100(1):61-6
24530740
Tissue Cell. 1996 Apr;28(2):127-36
8650667
Aquat Toxicol. 2014 May;150:83-92
24658013
Recent Prog Horm Res. 2002;57:149-79
12017541
Neurosci Lett. 2007 Jan 22;412(1):29-33
17156917
Mol Endocrinol. 2006 Nov;20(11):2613-29
16543404
J Environ Sci Health A Tox Hazard Subst Environ Eng. 2012;47(9):1202-6
22540640
Biol Trace Elem Res. 2011 Dec;144(1-3):924-43
21537923
Toxicology. 2005 Nov 5;215(1-2):97-107
16098653
Behav Processes. 2009 Nov;82(3):279-85
19635532
Toxicology. 1997 Jan 15;116(1-3):1-8
9020501
Toxicology. 2006 Feb 1;218(2-3):112-24
16289752
J Reprod Fertil. 1986 Jan;76(1):83-9
3511257
Oecologia. 1994 May;97(4):491-498
28313738
Arch Toxicol. 1995;69(8):568-71
8534202
Physiol Behav. 2007 Feb 28;90(2-3):483-9
17145068
Physiol Behav. 2003 Jul;79(2):305-10
12834803
Food Chem Toxicol. 2002 Dec;40(12):1875-80
12419702
Arch Environ Contam Toxicol. 2007 May;52(4):603-13
17387425
Indian J Exp Biol. 1993 Jan;31(1):30-5
8500814
Hepatology. 2012 Oct;56(4):1279-90
22684873
Biol Trace Elem Res. 2011 Dec;144(1-3):1050-8
21647756
J Radiat Res. 2009 May;50(3):261-6
19531924
Environ Pollut. 2004 Sep;131(1):71-9
15210277
Nephron Exp Nephrol. 2010;115(4):e112-21
20424489
Science. 2013 Apr 5;340(6128):63-6
23559246
Ann N Y Acad Sci. 2006 Nov;1089:228-36
17261770
Cell. 2010 Jan 22;140(2):197-208
20141834
Ecotoxicology. 2014 Oct;23(8):1546-54
25098774
Life Sci. 2014 Apr 25;102(1):36-40
24607783
Neurotoxicol Teratol. 1992 Jul-Aug;14(4):259-64
1522831