Reversal of a Suspected Paradoxical Reaction to Zopiclone with Flumazenil.
We describe the care for an elderly woman who was admitted to the intensive care unit (ICU) to receive noninvasive ventilation for acute exacerbation of chronic obstructive pulmonary disease. After administration of the sleeping pill zopiclone, a nonbenzodiazepine receptor agonist (NBRA), the patient became agitated and was confused, a possible paradoxical reaction to benzodiazepines. These symptoms were immediately resolved after treatment with flumazenil, usually used to reverse the adverse effects of benzodiazepines or NBRAs and to reverse paradoxical reactions to benzodiazepines. This case indicates that zopiclone induced behavioral changes resembling a paradoxical reaction to benzodiazepines and these symptoms may be treated with flumazenil.
Department of Anaesthesiology, Rigshospitalet, Glostrup Matriklen, Copenhagen, Denmark.
Zarah
0000-0002-7402-6065
Z
Jordahn
Department of Anaesthesiology, Copenhagen University Hospital, Hvidovre, Denmark.
Cheme
C
Andersen
Department of Anaesthesia and Intensive Care, Bispebjerg Hospital, Copenhagen, Denmark.
Anne Marie
AM
Roust Aaberg
Department of Anaesthesia and Intensive Care, Bispebjerg Hospital, Copenhagen, Denmark.
Frank
0000-0002-7874-6991
F
Christian Pott
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