Deceased organ donation for transplantation: Challenges and opportunities.
Organ transplantation saves thousands of lives every year but the shortage of donors is a major limiting factor to increase transplantation rates. To allow more patients to be transplanted before they die on the wait-list an increase in the number of donors is necessary. Patients with devastating irreversible brain injury, if medically suitable, are potential deceased donors and strategies are needed to successfully convert them into actual donors. Multiple steps in the process of deceased organ donation can be targeted to increase the number of organs suitable for transplant. In this review, after describing this process, we discuss current challenges and potential strategies to expand the pool of deceased donors.
Raffaele Girlanda, Transplant Institute, Georgetown University Hospital, Washington, DC 20007, United States.
Raffaele
R
Girlanda
Consent; Eligible death; Imminent brain death; Organ procurement; Potential organ donor
Clin Transplant. 2009 Dec;23 Suppl 21:2-9
19930309
Transplantation. 2016 Feb;100(2):446-50
26516669
Fed Regist. 1998 Jun 22;63(119):33856-75
10180282
Transplantation. 2015 Dec;99(12):2431-3
26627668
Am J Transplant. 2015 Aug;15(8):2117-25
26031323
J Trauma Acute Care Surg. 2014 Jun;76(6):1473-5
24854318
Hastings Cent Rep. 1999 Nov-Dec;29(6):6-14
10641238
Transpl Int. 2011 Jul;24(7):676-86
21504489
Am J Transplant. 2012 Jun;12(6):1598-602
22443186
Transplantation. 2015 Sep;99(9):1739-42
26308407
Transplantation. 1991 Jan;51(1):142-9
1987683
Acad Emerg Med. 2009 Sep;16(9):850-8
19673710
Am J Transplant. 2012 Sep;12(9):2507-13
22703439
Transplantation. 2015 Nov;99(11):2231-3
26492047
JAMA. 1992 Jan 8;267(2):239-46
1727520
J Neurol. 2008 Feb;255(2):217-23
18283406
Transplantation. 2011 Jun 15;91 Suppl 11:S29-31
21633281
N Engl J Med. 2003 Aug 14;349(7):667-74
12917304
Curr Opin Organ Transplant. 2011 Apr;16(2):243-9
21415828
J Trauma. 2010 Feb;68(2):447-51
20154557
Br J Anaesth. 2012 Jan;108 Suppl 1:i96-107
22194439
Transpl Int. 2013 May;26(5):517-26
23517301
Crit Care Med. 1996 Mar;24(3):432-9
8625631
Crit Care Med. 2015 Jun;43(6):1291-325
25978154
Am J Transplant. 2008 Oct;8(10):2132-9
18727699
Am J Bioeth. 2014;14(8):21-3
25046289
Transplantation. 1999 Feb 27;67(4):548-56
10071026
Am J Surg. 2013 Apr;205(4):381-6
23414636
JAMA. 1968 Aug 5;205(6):337-40
5694976
Transplantation. 2010 Aug 15;90(3):229-33
20664493
Transplantation. 2012 Dec 15;94(11):1167-71
23114533