Depression accelerates the development of gastric cancer through reactive oxygen species‑activated ABL1 (Review).
Depression is a common symptom among gastric cancer (GC) patients and serves as a potential indication of poor prognosis and advanced cancer clinical stage. However, the molecular mechanism of depression‑associated poor prognoses of GC patients remains unclear. Recent studies have revealed that GC patients with depression are under high levels of oxidative stress (OS) status that is accompanied by the dysfunction of numerous proto‑oncogenes, including the ABL proto‑oncogene 1 (ABL1), which is a non‑receptor tyrosine kinase. Recent evidence indicates that ABL1 was dysregulated in both major depressive disorder (MDD) and cancer patients with depression, and high levels of reactive oxygen species (ROS) can lead to the activation of ABL1 in response to OS and that activated ABL1 subsequently contributes to development of GC via interactions with the downstream targets and corresponding signaling pathways. In this review, we examine the evidence to illuminate the molecular mechanism of ABL1 in the progression of GC patients with depression and identify out new and effective methods for the initial and long‑term treatment of GC.
Department of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
Tianhe
T
Huang
Department of Clinical Hematology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, P.R. China.
Fuling
F
Zhou
Viral Oncology Program, SRI International, Menlo Park, CA 94025, USA.
Feng
F
Wang-Johanning
Department of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
Kejun
K
Nan
Department of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
Yongchang
Y
Wei
D003866:Depressive Disorder / Q000188:drug therapy / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016374:Oncogene Proteins v-abl / Q000096:biosynthesis* / Q000235:genetics; D018384:Oxidative Stress / Q000235:genetics; D011379:Prognosis; D017382:Reactive Oxygen Species; D013274:Stomach Neoplasms / Q000150:complications / Q000188:drug therapy / Q000235:genetics* / Q000523:psychology
D016374:Oncogene Proteins v-abl; D017382:Reactive Oxygen Species