[Impact of concomitant use of P2Y12 inhibitors and proton pump inhibitors on ischemia events in patients with acute coronary syndrome in real world].
Objective:The study aimed to analyze the impact of concomitant administration of P2Y12 inhibitors and PPIs on ischemia events in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI).Methods:We retrospectively analyzed data from a international, multi-center registry between 2003 and 2014 in patients with ACS after PCI, grouped the cohort into patients receiving PPIs or no PPIs and assessed 1-year clinical endpoint (all-cause death/re-infarction). Meanwhile, we grouped the cohort into patients receiving clopidogrel or ticagrelor, and compared the impact of concomitant administration of PPIs and clopidogrel or ticagrelor on 1-year clinical endpoint.Results:Of 9 429 patients in the final cohort, 54.8% (n=5 165) was prescribed a PPI at discharge. Patients receiving a PPI were more likely to have comorbidities. No association was observed between PPI use and the clinical endpoint (HR 1.00, 95%CI0.86-1.18). Meanwhile, no association was found between PPI use and the clinical endpoint in patients receiving either clopidogrel or ticagrelor. And the clinical endpoint in patients administrated of clopidogrel and PPIs had no difference with that of ticagrelor and PPIs.Conclusions:In patients with ACS following PCI, increased risk of ischemia event was not found in the concomitant use of PPIs and P2Y12 inhibitors, and especially, compared with ticagrelor, clopidogrel was found no association with ischemia events when concomitant administrated with PPIs.
Department of Emergency and Critical Care Center, Anzhen Hospital, Capital Medical University, Beijing 100029, China.
S T
ST
Feng
Y
Y
Yan
J Y
JY
Fan
X
X
Wang
W
W
Zheng
S P
SP
Nie
Sergio
S
Raposeiras-Roubín
Emad
E
Abu-Assi
Jose P
JP
Simao Henriques
Fabrizio
F
D Ascenzo
Jorge
J
Saucedo
José R
JR
González-Juanatey
Stephen B
SB
Wilton
Wouter J
WJ
Kikkert
Iván
I
Nuñez-Gil
Albert
A
Ariza-Sole
Dimitrios
D
Alexopoulos
Christoph
C
Liebetrau
Tetsuma
T
Kawaji
Claudio
C
Moretti
Zenon
Z
Huczek
Toshiharu
T
Fujii
Luis C
LC
Correia
Masa-Aki
MA
Kawashiri
Sasko
S
Kedev
D054058:Acute Coronary Syndrome / Q000188:drug therapy*; D006801:Humans; D007511:Ischemia / Q000188:drug therapy*; D062645:Percutaneous Coronary Intervention; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D058921:Purinergic P2Y Receptor Antagonists / Q000627:therapeutic use*; D012042:Registries; D012189:Retrospective Studies; D016896:Treatment Outcome
D054328:Proton Pump Inhibitors; D058921:Purinergic P2Y Receptor Antagonists