Effect of aerobic exercise against vanadyl sulphate-induced nephrotoxicity and hepatotoxicity in rats.
BACKGROUND
Vanadium compounds are insulin like drugs which are accompanied with nephrotoxicity and hepatotoxicity as their major side effects. Aerobic exercise is well known as an approach to reduce the side effects of many drugs.


OBJECTIVE
This study was designed to determine the role of aerobic exercise against vanadyl sulphate induced nephrotoxicity and hepatotoxicity in male rats.


METHODS
Twenty-four male Wistar rats were randomly divided into three groups. Group I had aerobic exercise on a treadmill 5 days/week for 6 weeks. Group II received vanadyl sulphate (50 mg/kg/week; i.p.) for 6 weeks. Group III had combination of exercise and vanadyl sulphate therapy as groups 1 and 2. At the end of study, blood samples were obtained, and the animals were sacrificed for the tissues injury determination.


RESULTS
Vanadyl sulphate alone increased serum levels of blood urea nitrogen (BUN), creatinine (Cr), and kidney weight (KW) and kidney tissue damage score (KTDS) (P<0.05). These observations revealed nephrotoxicity induced by vanadyl sulphate, although exercise training did not attenuate these results. In addition, vanadyl sulphate alone induced liver tissue damage score and exercise training intensified it insignificantly, while the serum levels of aspartate amino transferase and alanine amino transferase were greater in exercise alone group than others groups.


CONCLUSIONS
Aerobic exercise could not attenuate vanadyl sulphate induced nephrotoxicity and hepatotoxicity. These findings must be considered when vanadyl sulphate is suggested as insulin like drug.
Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ; Department of Sport Physiology, University of Isfahan, Isfahan, Iran.
Fatemeh
F
Ahmadi
Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ; Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran ; IsfahanMN Institute of Basic & Applied Sciences Research, Isfahan, Iran.
Mehdi
M
Nematbakhsh
Department of Sport Physiology, University of Isfahan, Isfahan, Iran.
Mehdi
M
Kargarfard
Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Fatemeh
F
Eshraghi-Jazi
Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Ardeshir
A
Talebi
Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Soheila
S
Shirdavani
Aerobic exercise; Hepatotoxicity; Nephrotoxicity; Rat; Vanadyl sulphate
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