Femoral Bone Marrow Insulin Sensitivity Is Increased by Resistance Training in Elderly Female Offspring of Overweight and Obese Mothers.
Bone marrow insulin sensitivity may be an important factor for bone health in addition to bone mineral density especially in insulin resistant conditions. First we aimed to study if prenatal maternal obesity plays a role in determining bone marrow insulin sensitivity in elderly female offspring. Secondly we studied if a four-month individualized resistance training intervention increases bone marrow insulin sensitivity in elderly female offspring and whether this possible positive outcome is regulated by the offspring’s mother’s obesity status. 37 frail elderly females (mean age 71.9 ± 3.1 years) of which 20 were offspring of lean/normal-weight mothers (OLM, maternal BMI ≤ 26.3 kg/m2) and 17 were offspring of obese/overweight mothers (OOM, maternal BMI ≥ 28.1 kg/m2) were studied before and after a four-month individualized resistance training intervention. Nine age- and sex-matched non-frail controls (maternal BMI ≤ 26.3 kg/m2) were studied at baseline. Femoral bone marrow (FBM) and vertebral bone marrow (VBM) insulin sensitivity were measured using [18F]fluoro-2-deoxy-D-glucose positron emission tomography with computer tomography under hyperinsulinemic euglycemic clamp. We found that bone marrow insulin sensitivity was not related to maternal obesity status but FBM insulin sensitivity correlated with whole body insulin sensitivity (R = 0.487, p = 0.001). A four-month resistance training intervention increased FBM insulin sensitivity by 47% (p = 0.006) only in OOM, while VBM insulin sensitivity remained unchanged regardless of the maternal obesity status. In conclusion, FBM and VBM glucose metabolism reacts differently to a four-month resistance training intervention in elderly women according to their maternal obesity status.



ClinicalTrials.gov NCT01931540.
Turku PET Centre, University of Turku, Turku, Finland.|Department of Radiology, University of Turku and Turku University Hospital, Turku, Finland.
Ville
V
Huovinen
Turku PET Centre, University of Turku, Turku, Finland.
Marco
M
Bucci
Turku PET Centre, University of Turku, Turku, Finland.
Heta
H
Lipponen
Department of Endocrinology, Turku University Hospital, Turku, Finland.|Departments of Medicine and Medical Biochemistry and Genetics, University of Turku, Turku, Finland.
Riku
R
Kiviranta
Folkhälsan Research Centre, Helsinki, Finland.|National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland.
Samuel
S
Sandboge
Turku PET Centre, University of Turku, Turku, Finland.
Juho
J
Raiko
Turku PET Centre, University of Turku, Turku, Finland.
Suvi
S
Koskinen
Turku PET Centre, University of Turku, Turku, Finland.
Kalle
K
Koskensalo
National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland.|Department of General Practice and Primary Health Care, University of Helsinki, and Helsinki University Hospital Finland, Helsinki, Finland.
Johan G
JG
Eriksson
Turku PET Centre, University of Turku, Turku, Finland.|Department of Radiology, University of Turku and Turku University Hospital, Turku, Finland.
Riitta
R
Parkkola
Turku PET Centre, University of Turku, Turku, Finland.|Institute of Clinical Physiology, National Research Council (CNR), Pisa, Italy.
Patricia
P
Iozzo
Turku PET Centre, University of Turku, Turku, Finland.|Department of Endocrinology, Turku University Hospital, Turku, Finland.
Pirjo
P
Nuutila
D000368:Aged; D001853:Bone Marrow / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging; D016330:Frail Elderly; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance; D009765:Obesity / Q000503:physiopathology*; D050177:Overweight / Q000503:physiopathology*; D049268:Positron-Emission Tomography; D055070:Resistance Training; D014057:Tomography, X-Ray Computed
D005947:Glucose
Biochem Cell Biol. 2012 Oct;90(5):613-20
22812431
J Bone Miner Res. 2013 Aug;28(8):1721-8
23558967
J Clin Endocrinol Metab. 2002 Aug;87(8):3902-10
12161530
J Cereb Blood Flow Metab. 1985 Dec;5(4):584-90
4055928
Pediatr Radiol. 2013 Mar;43 Suppl 1:S181-92
23478934
J Clin Invest. 1992 Jun;89(6):1767-74
1601987
Diabet Med. 2013 May;30(5):535-48
23173973
J Nucl Med. 1986 Feb;27(2):235-8
3712040
Bone. 2014 Apr;61:33-8
24389418
Eur J Radiol. 2013 Nov;82(11):e697-702
23938236
Int J Obes (Lond). 2007 Sep;31(9):1392-9
17356523
Am J Physiol Endocrinol Metab. 2000 Nov;279(5):E1122-30
11052968
J Clin Endocrinol Metab. 2013 Jun;98(6):2294-300
23553860
Ann Med. 2014 Sep;46(6):434-8
24910160
Hypertension. 2008 Feb;51(2):383-92
18086952
J Magn Reson Imaging. 2001 Feb;13(2):263-8
11169833
Lancet Diabetes Endocrinol. 2015 Feb;3(2):141-7
24731667
Mol Aspects Med. 2013 Feb;34(1):1-11
23068073
J Clin Endocrinol Metab. 2013 Mar;98(3):935-45
23393168
Eur J Radiol. 2008 Aug;67(2):275-84
18406092
Diabetes Care. 2009 Jun;32(6):1076-80
19460915
Osteoporos Int. 2014 Feb;25(2):551-8
23892583
Acta Obstet Gynecol Scand. 2014 Nov;93(11):1099-108
25179736
Med Sci Sports Exerc. 2015 Aug;47(8):1587-95
25386713
J Magn Reson Imaging. 2012 Nov;36(5):1011-4
22777847
Diabetes Care. 2008 Sep;31(9):1872-6
18535193
Am J Physiol. 1979 Sep;237(3):E214-23
382871
Obes Facts. 2014;7(2):130-51
24801105
Magn Reson Med. 1993 Dec;30(6):672-9
8139448
J Magn Reson Imaging. 2012 Jan;35(1):117-24
22190287
Age Ageing. 2003 Nov;32(6):650-6
14600007
Curr Pharm Des. 2008;14(4):405-10
18289066
Radiology. 1990 Apr;175(1):219-23
2315484
Am J Physiol Endocrinol Metab. 2013 Aug 15;305(4):E496-506
23800880
Osteoporos Int. 2014 Mar;25(3):999-1004
24030288
Adv Prev Med. 2011;2011:984683
21991450
Diabetologia. 2016 Jan;59(1):77-86
26486356