Mutating heme oxygenase-1 into a peroxidase causes a defect in bilirubin synthesis associated with microcytic anemia and severe hyperinflammation.
Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Germany.
Johann
J
Greil
Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Germany.
Maria V
MV
Verga-Falzacappa
Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Germany.
Nicole E
NE
Echner
Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Germany.
Wolfgang
W
Behnisch
Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Germany.
Obul R
OR
Bandapalli
Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Germany.
Paulina
P
Pechanska
Institute for Transfusion Medicine, Hannover Medical School, Germany.
Stephan
S
Immenschuh
Institute for Transfusion Medicine, Hannover Medical School, Germany.
Vijith
V
Vijayan
Department. of Nephrology, Medical and Health Science Center, University of Debrecen, Hungary.|MTA-DE Vascular Biology, Thrombosis and Hemostasis Research Group, Hungarian Academy of Sciences Debrecen, Hungary.
Jozsef
J
Balla
Department of Pediatrics, Okayama University Graduate School of Medicine, Japan.
Hirokatsu
H
Tsukahara
Section of Experimental Anesthesiology, University of Ulm, Germany.
Marion
M
Schneider
Department of Hematology and Oncology, Children's Hospital, University of Hamburg, Germany.
Gritta
G
Janka
Institute for Immunology, University Heidelberg, Germany.
Maren
M
Claus
Institute of Pathology, University of Heidelberg, Germany.
Thomas
T
Longerich
Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Germany andreas.kulozik@med.uni-heidelberg.de martina.muckenthaler@med.uni-heidelberg.de.
Martina U
MU
Muckenthaler
Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Germany andreas.kulozik@med.uni-heidelberg.de martina.muckenthaler@med.uni-heidelberg.de.
Andreas E
AE
Kulozik
D018798:Anemia, Iron-Deficiency / Q000209:etiology*; D001663:Bilirubin / Q000096:biosynthesis*; D051547:Heme Oxygenase-1 / Q000235:genetics*; D006801:Humans; D007223:Infant; D007249:Inflammation / Q000209:etiology*; D008264:Macrophages / Q000276:immunology; D008297:Male; D018384:Oxidative Stress; D009195:Peroxidase / Q000235:genetics*
D009195:Peroxidase; D051547:Heme Oxygenase-1; D001663:Bilirubin
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