Characterization of three dimensional volumetric strain distribution during passive tension of the human tibialis anterior using Cine Phase Contrast MRI.
Intramuscular pressure correlates strongly with muscle tension and is a promising tool for quantifying individual muscle force. However, clinical application is impeded by measurement variability that is not fully understood. Previous studies point to regional differences in IMP, specifically increasing pressure with muscle depth. Based on conservation of mass, intramuscular pressure and volumetric strain distributions may be inversely related. Therefore, we hypothesized volumetric strain would decrease with muscle depth. To test this we quantified 3D volumetric strain in the tibialis anterior of 12 healthy subjects using Cine Phase Contrast Magnetic Resonance Imaging. Cine Phase Contrast data were collected while a custom apparatus rotated the subjects' ankle continuously between neutral and plantarflexion. A T2-weighted image stack was used to define the resting tibials anterior position. Custom and commercial post-processing software were used to quantify the volumetric strain distribution. To characterize regional strain changes, the muscle was divided into superior-inferior sections and either medial-lateral or anterior-posterior slices. Mean volumetric strain was compared across the sections and slices. As hypothesized, volumetric strain demonstrated regional differences with a decreasing trend from the anterior (superficial) to the posterior (deep) muscle regions. Statistical tests showed significant main effects and interactions of superior-inferior and anterior-posterior position as well as superior-inferior and medial-lateral position on regional strain. These data support our hypothesis and imply a potential relationship between regional volumetric strain and intramuscular pressure. This finding may advance our understanding of intramuscular pressure variability sources and lead to more reliable measurement solutions in the future.
Mayo Graduate School, Biomedical Engineering and Physiology Track, Mayo Clinic, Rochester, MN 55905, USA; Motion Analysis Laboratory, Division of Orthopedic Research, Mayo Clinic, Rochester, MN 55905, USA.
Elisabeth R
ER
Jensen
Motion Analysis Laboratory, Division of Orthopedic Research, Mayo Clinic, Rochester, MN 55905, USA.
Duane A
DA
Morrow
Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Joel P
JP
Felmlee
Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Naveen S
NS
Murthy
Motion Analysis Laboratory, Division of Orthopedic Research, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: kaufman.kenton@mayo.edu.
Kenton R
KR
Kaufman
D000842:Ankle / Q000502:physiology; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging* / Q000502:physiology*; D011312:Pressure; D012146:Rest; D013314:Stress, Mechanical; D013977:Tibia
Cine Phase Contrast; Intramuscular pressure; Tibialis anterior; Volumetric strain
J Mech Behav Biomed Mater. 2016 Oct;63:207-19
27429070
J Appl Physiol (1985). 1993 Jun;74(6):2634-40
8365963
Surg Radiol Anat. 2011 Dec;33(10):869-79
21912991
Acta Physiol Scand. 2001 Nov;173(3):297-311
11736692
J Electromyogr Kinesiol. 2001 Apr;11(2):85-94
11228422
Adv Exp Med Biol. 1995;384:339-50
8585463
J Ultrasound. 2013 Dec 19;17(2):113-23
24883132
J Biomech Eng. 2013 Sep;135(9):91003
23722229
Muscle Nerve. 2009 Jul;40(1):79-85
19533654
Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9185-90
22615376
J Biomech. 2003 Feb;36(2):283-7
12547368
J Magn Reson Imaging. 2012 Aug;36(2):498-504
22392816
J Magn Reson Imaging. 2007 Jan;25(1):175-84
17152055
J Appl Physiol (1985). 2003 Aug;95(2):829-37
12716873
Eur J Appl Physiol Occup Physiol. 1992;65(2):178-82
1396642
Eur J Appl Physiol Occup Physiol. 1983;51(3):395-408
6685038
Stat Methods Med Res. 1999 Jun;8(2):135-60
10501650
Arch Physiol Biochem. 2003 Oct;111(4):377-88
15764078
J Magn Reson Imaging. 1995 May-Jun;5(3):339-45
7633112
Scand J Med Sci Sports. 1995 Oct;5(5):291-6
8581572
Muscle Nerve. 2007 Sep;36(3):313-9
17554796
J Biomech. 2008;41(3):532-40
18177655
Acta Orthop Scand. 1993 Jun;64(3):377-81
8322604
J Appl Physiol Respir Environ Exerc Physiol. 1984 Feb;56(2):287-95
6706739
Am J Physiol. 1990 Dec;259(6 Pt 2):H1860-8
2260710
J Biomech. 2003 Apr;36(4):505-12
12600341
Clin Orthop Relat Res. 1979 Nov-Dec;(145):292-9
535286
Acta Anat (Basel). 1997;158(4):287-95
9416360
J Biomech. 2005 Apr;38(4):657-65
15713285
J Exp Biol. 2016 May 15;219(Pt 10):1432-6
26994184
Phys Med Biol. 2002 Nov 21;47(22):4043-61
12476981
Ann Biomed Eng. 2009 Aug;37(8):1638-45
19495983
J Appl Physiol (1985). 1998 Jun;84(6):1976-81
9609792
Physiol Meas. 2015 Dec;36(12 ):N135-46
26595686
J Appl Physiol (1985). 2002 Jun;92(6):2381-9
12015351
J Appl Physiol (1985). 1997 Dec;83(6):1867-76
9390957
J Biomech. 2010 Aug 26;43(12):2254-60
20472238
J Biomech. 2001 Jul;34(7):927-40
11410176
Magn Reson Med. 2008 Dec;60(6):1329-36
19025882
J Biomech. 2003 Dec;36(12):1797-811
14614933
Muscle Nerve. 1999 May;22(5):578-83
10331356
J Appl Physiol (1985). 2008 Oct;105(4):1312-20
18703759
Ann Biomed Eng. 2005 May;33(5):661-73
15981866
J Biomech. 2015 Jan 2;48(1):95-103
25433567