Detection of central circuits implicated in the formation of novel pain memories.
Being able to remember physically and emotionally painful events in one's own past may shape behavior, and can create an aversion to a variety of situations. Pain imagination is a related process that may include recall of past experiences, in addition to production of sensory and emotional percepts without external stimuli. This study aimed to understand 1) the central nervous system processes that underlie pain imagination, 2) the retrieval of pain memories, and 3) to compare the latter with visual object memory. These goals were achieved by longitudinally investigating brain function with functional magnetic resonance imaging in a unique group of healthy volunteers who had never experienced tooth pain. In these subjects, we compared brain responses elicited during three experimental conditions in the following order: imagination of tooth pain (pain imagination), remembering one's own house (object memory), and remembrance of tooth pain following an episode of induced acute tooth pain (pain memory). Key observations stemming from group-level conjunction analyses revealed common activation in the posterior parietal cortex for both pain imagination and pain memory, while object and pain memory each had strong activation predominantly within the middle frontal gyrus. When contrasting pain imagination and memory, significant activation differences were observed in subcortical structures (ie, parahippocampus - pain imagination > pain memory; midbrain - pain memory > pain imagination). Importantly, these findings were observed in the presence of consistent and reproducible psychophysical and behavioral measures that informed on the subjects' ability to imagine novel and familiar thoughts, as well as the subjects' pain perception.
Department of Neurology.
Jaymin
J
Upadhyay
Department of Neurology.
Julia
J
Granitzka
Department of Neuroradiology, University Medical Centre, Johannes Gutenberg University Mainz, Mainz.
Thomas
T
Bauermann
Department of Neurophysiology, Center for Biomedicine and Medical Technology Mannheim (CBTM), Heidelberg University, Mannheim, Germany.
Ulf
U
Baumgärtner
Department of Neurology.
Markus
M
Breimhorst
Department of Neurophysiology, Center for Biomedicine and Medical Technology Mannheim (CBTM), Heidelberg University, Mannheim, Germany.
Rolf-Detlef
RD
Treede
Department of Neurology.
Frank
F
Birklein
fMRI; object memory; pain imagination; pain memory; tooth pain
J Cogn Neurosci. 2005 Dec;17(12):1923-35
16356329
Eur J Pain. 1999 Dec;3(4):325-333
10700360
Cephalalgia. 2006 Nov;26(11):1335-43
17059441
Prog Brain Res. 2000;129:313-22
11098699
J Neurosci. 2000 Oct 1;20(19):7438-45
11007903
J Neurosci. 2009 Jan 28;29(4):930-8
19176802
Pain. 2014 Jan;155(1):129-36
24055334
Pain Manag. 2013 Jan;3(1):35-45
24645930
Pain. 2007 Nov;132(1-2):16-7
17822847
Br J Psychol. 1973 Feb;64(1):17-24
4742442
Neuroimage. 2011 Mar 1;55(1):8-23
21111053
Eur J Pain. 2005 Aug;9(4):463-84
15979027
Ann Behav Med. 1998 Winter;20(1):31-5
9755349
Z Klin Psychol Psychopathol Psychother. 1992;40(1):20-33
1585704
Pain. 2013 Oct;154(10):1989-98
23769719
Acta Psychiatr Scand. 1983 Jun;67(6):361-70
6880820
Brain Res. 2016 Sep 1;1646:249-61
27288703
Pain. 2009 May;143(1-2):97-105
19269743
Clin J Pain. 2002 Jan-Feb;18(1):56-63
11803304
Pain. 2002 Jun;97(3):213-21
12044618
Neuroimage. 2012 Oct 15;63(1):54-62
22732556
Yale J Biol Med. 2010 Mar;83(1):11-25
20351978
Mem Cognit. 2007 Sep;35(6):1205-10
18035621
Neurology. 2006 Mar 14;66(5):711-7
16534108
J Pain. 2008 Apr;9(4):342-9
18226967
Semin Clin Neuropsychiatry. 1996 Oct;1(4):315-324
10320434
Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1257-62
15657126
Brain Connect. 2014 Feb;4(1):53-69
24308753
Curr Opin Neurobiol. 2002 Apr;12 (2):195-204
12015237
J Consult Clin Psychol. 1992 Aug;60(4):528-36
1506501
Cereb Cortex. 2007 Jan;17(1):230-7
16495434
PLoS One. 2012;7(10):e48711
23119093
J Neurosci. 2003 May 15;23(10):4315-23
12764120
Learn Mem. 1998 Nov-Dec;5(6):446-66
10489261
Neuron. 2000 Dec;28(3):979-90
11163281
Front Behav Neurosci. 2015 Apr 10;9:82
25914633
Neuroimage. 2009 Mar 1;45(1):122-8
19100840
Curr Opin Neurobiol. 2003 Aug;13(4):500-5
12965300
Neuroimage. 2011 Feb 1;54(3):2492-502
20946964
J Neurosci. 2011 May 18;31(20):7441-9
21593327
J Neurosci. 2011 May 18;31(20):7322-33
21593316
Anesth Analg. 2007 May;104(5):1223-9, tables of contents
17456678
Brain Struct Funct. 2016 Apr;221(3):1555-71
25613901
Neuroimage Clin. 2015 Jun 28;8:572-82
26236627
Neuron. 2007 Aug 2;55(3):377-91
17678852
Hum Brain Mapp. 2013 Mar;34(3):598-612
22102377
J Neurosci. 2010 Dec 1;30(48):16324-31
21123578
J Cogn Neurosci. 2003 May 15;15(4):574-83
12803968
Pain. 2006 Mar;121(1-2):69-76
16480824
Neuroimage. 2013 Dec;83:75-86
23800791
Pain Manag. 2012 Sep;2(5):487-97
24645865
J Cogn Neurosci. 2008 Feb;20(2):240-54
18275332
Psychiatry Res. 2013 Jul 30;213(1):39-46
23684980