Association between Serum Cystatin C and Diabetic Foot Ulceration in Patients with Type 2 Diabetes: A Cross-Sectional Study.
Serum cystatin C (CysC) has been identified as a possible potential biomarker in a variety of diabetic complications, including diabetic peripheral neuropathy and peripheral artery disease. We aimed to examine the association between CysC and diabetic foot ulceration (DFU) in patients with type 2 diabetes (T2D). 411 patients with T2D were enrolled in this cross-sectional study at a university hospital. Clinical manifestations and biochemical parameters were compared between DFU group and non-DFU group. The association between serum CysC and DFU was explored by binary logistic regression analysis. The cut point of CysC for DFU was also evaluated by receiver operating characteristic (ROC) curve. The prevalence of coronary artery disease, diabetic nephropathy (DN), and DFU dramatically increased with CysC (P< 0.01) in CysC quartiles. Multivariate logistic regression analysis indicated that the significant risk factors for DFU were serum CysC, coronary artery disease, hypertension, insulin use, the differences between supine and sitting TcPO2, and hypertension. ROC curve analysis revealed that the cut point of CysC for DFU was 0.735 mg/L. Serum CysC levels correlated with DFU and severity of tissue loss. Our study results indicated that serum CysC was associated with a high prevalence of DFU in Chinese T2D subjects.
Department of Endocrinology, Diabetic Foot Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Jie
J
Zhao
Department of Endocrinology, Diabetic Foot Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Wuquan
W
Deng
Department of Endocrinology, Diabetic Foot Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Yuping
Y
Zhang
Department of Endocrinology, Diabetic Foot Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Yanling
Y
Zheng
Department of Endocrinology, Diabetic Foot Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Lina
L
Zhou
Department of Podiatry, Singapore General Hospital, Singapore 169608.
Johnson
J
Boey
Department of Surgery, Southern Arizona Limb Salvage Alliance (SALSA), University of Arizona Health Sciences Center, Tucson, AZ 85724, USA.
David G
DG
Armstrong
Department of Endocrinology, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.
Gangyi
G
Yang
Department of Endocrinology, Diabetic Foot Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Ziwen
0000-0001-6909-2538
Z
Liang
Department of Endocrinology, Diabetic Foot Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Bing
0000-0001-6339-4738
B
Chen
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