Intelligence quotient scores at the age of 6 years in children anaesthetised before the age of 5 years.
We analysed the association of independent variables with non-verbal cognition at 6 years in children with complete data (3441 from a cohort of 9901), of whom 415 were anaesthetised before the age of 5 years. Using multivariable regression, cognition was reduced by a mean (95% CI) score for children: anaesthetised before the age of 5 years, 2.1 (0.7-3.5), p = 0.004; born prematurely, 9.8 (4.1-15.4), p = 0.001; whose mothers smoked while pregnant, 2.3 (0.8-3.8), p = 0.004; whose mothers had lower IQ scores, 0.3 (0.2-0.3) for each unit reduction in maternal IQ, p < 0.0001. The association of child IQ with exposure to anaesthetic drugs was sensitive to missing data.
Department of Anaesthesia, Erasmus University Medical Center, Rotterdam, The Netherlands.
I J
IJ
de Heer
Department of Child and Adolescent Psychiatry/Psychology, Sophia Children's Hospital, Erasmus University Medical Center, Rotterdam, The Netherlands.
H
H
Tiemeier
Department of Anaesthesia, Erasmus University Medical Center, Rotterdam, The Netherlands.
S E
SE
Hoeks
Department of Anaesthesia, Sophia Children's Hospital, Erasmus University Medical Center, Rotterdam, The Netherlands.
F
F
Weber
D000777:Anesthetics / Q000009:adverse effects / Q000494:pharmacology*; D002648:Child; D002657:Child Development / Q000187:drug effects*; D002675:Child, Preschool; D003071:Cognition / Q000187:drug effects; D015331:Cohort Studies; D015986:Confounding Factors, Epidemiologic; D016208:Databases, Factual; D002658:Developmental Disabilities / Q000139:chemically induced; D004522:Educational Status; D005260:Female; D006801:Humans; D007360:Intelligence / Q000187:drug effects*; D007361:Intelligence Tests; D008297:Male; D009035:Mothers / Q000706:statistics & numerical data; D019965:Neurocognitive Disorders / Q000139:chemically induced
D000777:Anesthetics
anaesthetic drugs; children; intelligence quotient scores; neurodevelopment; neurotoxicity