The Effect of Lateralization of Motor Onset and Emotional Recognition in PD Patients Using EEG.
The objective of this research was to investigate the relationship between emotion recognition and lateralization of motor onset in Parkinson's disease (PD) patients using electroencephalogram (EEG) signals. The subject pool consisted of twenty PD patients [ten with predominantly left-sided (LPD) and ten with predominantly right-sided (RPD) motor symptoms] and 20 healthy controls (HC) that were matched for age and gender. Multimodal stimuli were used to evoke simple emotions, such as happiness, sadness, fear, anger, surprise, and disgust. Artifact-free emotion EEG signals were processed using the auto regressive spectral method and then subjected to repeated ANOVA measures. No group differences were observed across behavioral measures; however, a significant reduction in EEG spectral power was observed at alpha, beta and gamma frequency oscillations in LPD, compared to RPD and HC participants, suggesting that LPD patients (inferred right-hemisphere pathology) are impaired compared to RPD patients in emotional processing. We also found that PD-related emotional processing deficits may be selective to the perception of negative emotions. Previous findings have suggested a hemispheric effect on emotion processing that could be related to emotional response impairment in a subgroup of PD patients. This study may help in clinical practice to uncover potential neurophysiologic abnormalities of emotional changes with respect to PD patient's motor onset.
Department of Biomedical Engineering, Sri Sivasubramaniya Nadar (SSN) College of Engineering, Rajiv Gandhi Salai (OMR), Kalavakkam, Chennai, Tamil Nadu, 603110, India. yuva2257@gmail.com.|Neural Systems Laboratory, Department of Biomedical Engineering, University of Kentucky, 143 Graham Ave, Lexington, KY, 40506-0108, USA. yuva2257@gmail.com.
R
R
Yuvaraj
Department of Electronics and Communication Engineering, Kuwait College of Science and Technology, Doha Area, 7th Ring Road, 13133, Safat, Kuwait.
M
M
Murugappan
School of Computing, University of Kent, Medway, UK.
R
R
Palaniappan
D000368:Aged; D000786:Anger; D001921:Brain / Q000503:physiopathology*; D016022:Case-Control Studies; D004569:Electroencephalography; D004644:Emotions; D005149:Facial Expression; D000066499:Facial Recognition / Q000502:physiology*; D005239:Fear; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006240:Happiness; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology*; D021641:Recognition, Psychology / Q000502:physiology; D012938:Social Perception
Body side of motor onset; EEG; Emotion; Parkinson’s disease