Targeting Glioma with a Dual Mode Optical and Paramagnetic Nanoprobe across the Blood-brain Tumor Barrier.
In brain tumors, delivering nanoparticles across the blood-tumor barrier presents major hurdles. A clinically relevant MRI contrast agent, GdDOTA and a near-infrared (NIR) fluorescent dye, DL680 were conjugated to a G5 PAMAM dendrimer, thus producing a dual-mode MRI and NIR imaging agent. Systemic delivery of the subsequent nano-sized agent demonstrated glioma-specific accumulation, probably due to the enhanced permeability and retention effect.In vivoMRI detected the agent in glioma tissue, but not in normal contralateral tissue; this observation was validated within vivoandex vivofluorescence imaging. A biodistribution study showed the agent to have accumulated in the glioma tumor and the liver, the latter being the excretion path for a G5 dendrimer-based agent.
Department of Neurology, Henry Ford Hospital, Detroit, MI 48202, USA.
Kishor
K
Karki
Department of Neurology, Henry Ford Hospital, Detroit, MI 48202, USA.
James R
JR
Ewing
Department of Neurology, Henry Ford Hospital, Detroit, MI 48202, USA.
Meser M
MM
Ali
Dual modality; Glioma; MRI; Optical imaging; Tumor blood-brain barrier
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