Kinase inhibitor ibrutinib to prevent cytokine-release syndrome after anti-CD19 chimeric antigen receptor T cells for B-cell neoplasms.
Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.|Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.|Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
M
M
Ruella
Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.|Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.|Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.|Department of Internal Medicine, Division of Hematology, Mayo Clinic, Rochester, MN, USA.
S S
SS
Kenderian
Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.|Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.|Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
O
O
Shestova
Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.|Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.|Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
M
M
Klichinsky
Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.|Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.|Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
J J
JJ
Melenhorst
Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.|Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
M A
MA
Wasik
Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.|Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.|Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
S F
SF
Lacey
Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.|Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.|Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.|Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA, USA.
C H
CH
June
Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.|Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.|Department of Internal Medicine, Division of Hematology, Mayo Clinic, Rochester, MN, USA.|Department of Medicine, Division of Hematology-Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
S
S
Gill
D000225:Adenine / Q000031:analogs & derivatives; D000818:Animals; D000906:Antibodies; D018941:Antigens, CD19 / Q000276:immunology*; D016207:Cytokines / Q000187:drug effects* / Q000378:metabolism; D064593:Heterografts; D006801:Humans; D016393:Lymphoma, B-Cell / Q000276:immunology; D051379:Mice; D010880:Piperidines; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D011720:Pyrazoles / Q000494:pharmacology / Q000627:therapeutic use*; D011743:Pyrimidines / Q000494:pharmacology / Q000627:therapeutic use*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D011993:Recombinant Fusion Proteins / Q000276:immunology; D013577:Syndrome
D000906:Antibodies; D018941:Antigens, CD19; D016207:Cytokines; D010880:Piperidines; D047428:Protein Kinase Inhibitors; D011720:Pyrazoles; D011743:Pyrimidines; D011948:Receptors, Antigen, T-Cell; D011993:Recombinant Fusion Proteins; C551803:ibrutinib; D000225:Adenine
Blood. 2016 Mar 3;127(9):1117-27
26813675
Blood. 2014 Jul 10;124(2):188-95
24876563
N Engl J Med. 2013 Aug 8;369(6):507-16
23782157
Clin Cancer Res. 2016 Jun 1;22(11):2684-96
26819453
Blood. 2014 Mar 20;123(12):1957-60
24652965
N Engl J Med. 2014 Oct 16;371(16):1507-17
25317870
Sci Transl Med. 2014 Feb 19;6(224):224ra25
24553386
N Engl J Med. 2013 Jul 4;369(1):32-42
23782158
Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):E966-72
25730880
Cancer Discov. 2016 Jun;6(6):664-79
27076371
Cancer J. 2014 Mar-Apr;20(2):119-22
24667956
Curr Hematol Malig Rep. 2016 Oct;11(5):368-84
27475429
Sci Transl Med. 2011 Aug 10;3(95):95ra73
21832238
Blood. 2013 Oct 10;122(15):2539-49
23886836