ER to Golgi-Dependent Protein Secretion: The Conventional Pathway.
Secretion is the cellular process present in every organism that delivers soluble proteins and cargoes to the extracellular space. In eukaryotes, conventional protein secretion (CPS) is the trafficking route that secretory proteins undertake when are transported from the endoplasmic reticulum (ER) to the Golgi apparatus (GA), and subsequently to the plasma membrane (PM) via secretory vesicles or secretory granules. This book chapter recalls the fundamental steps in cell biology research contributing to the elucidation of CPS; it describes the most prominent examples of conventionally secreted proteins in eukaryotic cells and the molecular mechanisms necessary to regulate each step of this process.
Institute of Biochemistry and Biology, Plant Physiology, University of Potsdam, Karl-Liebknecht-Str. 24-25, Building 20, 14476, Potsdam, Germany. viotti@uni-potsdam.de.
Corrado
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Viotti
D000818:Animals; D022181:COP-Coated Vesicles / Q000378:metabolism; D020755:Coat Protein Complex I / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism*; D006801:Humans; D021381:Protein Transport; D011506:Proteins / Q000378:metabolism*; D055571:Secretory Pathway; D022142:Secretory Vesicles / Q000378:metabolism; D020691:rab GTP-Binding Proteins / Q000378:metabolism
D020755:Coat Protein Complex I; D011506:Proteins; D020691:rab GTP-Binding Proteins
COPI; COPII; ER; Golgi; Plasma membrane; Regulated secretion; Ribosome; SNARE; SRP; Secretory granules; Secretory vesicles; TGN; Translocon