Lubricin in synovial fluid of mild and severe temporomandibular joint internal derangements.
BACKGROUND
To understand the molecular basis of temporomandibular joint (TMJ) pathologies, we aimed to investigate the lubricin levels in the TMJ synovial fluid (SF) of patients with mild to severe internal derangements (IDs).


METHODS
A total, 34 joints were the study group. Only patients, with a Wilkes stage of III, IV and V were included, in this sample. Control group consisted of SF from eight joints, from patients undergoing to orthognatic surgery. Concentrations of lubricin in the SF from both samples were measured using ELISA system.


RESULTS
The mean lubricin concentration was 7.029 ± 0.21 µg/mL in stage III patients; 5.64 ± 0.10 µg/mL in stage IV patients, and 4.78 ± 0.11 µg/mL in stage V patients. The lubricin levels from stage IV and stage V patients differed significantly (P ≤ 0.001) from those of control subjects. Lubricin levels were inversely correlated with age and to VAS score.


CONCLUSIONS
The results of this cross-sectional study highlight the relationship between disease severity and the levels of lubricin in TMJ SF. Our findings suggest that novel biotherapeutic approaches, including the administration of recombinant lubricin in the joint cavity, for the treatment of TMJ diseases can be developed.
University of Catania, Via S. Sofia 87, 95131, Catania, Italy, rleonard@unict.it.
R
R
Leonardi
R-E
RE
Perrotta
L-E
LE
Almeida
C
C
Loreto
G
G
Musumeci
D003430:Cross-Sectional Studies; D006023:Glycoproteins / Q000032:analysis*; D006801:Humans; D013582:Synovial Fluid / Q000737:chemistry; D013704:Temporomandibular Joint; D013705:Temporomandibular Joint Disorders; D000099158:Proteoglycan 4
D006023:Glycoproteins; D000099158:Proteoglycan 4
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