Dairy and plant based food intakes are associated with altered faecal microbiota in 2 to 3 year old Australian children.
The first 1000 days (conception to 24 months) is when gut microbiota composition and eating patterns are established, and a critical period influencing lifelong health. The aim of this study is to examine the associations between food intakes and microbiota composition at the end of this period. Diet was quantified for 37 well-nourished Australian children aged between 2 to 3 years by using a food frequency questionnaire and 24 hr recalls. Both dairy and plant-based (fruit, vegetables, soy, pulses and nuts) food intakes were associated with distinct microbiota profiles. Dairy intake was positively associated with the Firmicutes:Bacteroidetes ratio, and in particular Erysipelatoclostridium spp., but negatively associated with species richness and diversity. Vegetable intake was positively associated with the relative abundance of the Lachnospira genus, while soy, pulse and nut intake was positively associated with the relative abundance of bacteria related to Bacteroides xylanisolvens. Fruit intake, especially apples and pears, were negatively associated with the relative abundance of bacteria related to Ruminococcus gnavus. In this cohort of young children dairy and plant based food intakes were found to be associated with altered microbiota composition. Further exploration is needed to elucidate the effect of these dietary and microbial differences on host phenotype.
Children's Nutrition Research Centre, Child Health Research Centre, The University of Queensland, Australia.
P
P
Smith-Brown
The University of Queensland Diamantina Institute, Translational Research Institute, The University of Queensland, Australia.
M
M
Morrison
The University of Queensland Diamantina Institute, Translational Research Institute, The University of Queensland, Australia.
L
L
Krause
Children's Nutrition Research Centre, Child Health Research Centre, The University of Queensland, Australia.
P S W
PS
Davies
D001315:Australia; D015373:Bacterial Typing Techniques; D041963:Bacteroidetes / Q000145:classification* / Q000235:genetics / Q000254:growth & development; D002675:Child, Preschool; D015331:Cohort Studies; D004269:DNA, Bacterial / Q000235:genetics; D003611:Dairy Products / Q000032:analysis; D004032:Diet / Q000379:methods*; D004435:Eating / Q000502:physiology; D005243:Feces / Q000382:microbiology*; D005247:Feeding Behavior / Q000502:physiology; D005260:Female; D000068536:Bacillota / Q000145:classification* / Q000235:genetics / Q000254:growth & development; D005638:Fruit / Q000737:chemistry; D000069196:Gastrointestinal Microbiome / Q000502:physiology*; D006801:Humans; D008297:Male; D011795:Surveys and Questionnaires; D014675:Vegetables / Q000737:chemistry
D004269:DNA, Bacterial
Bioinformatics. 2012 Jul 15;28(14):1823-9
22556368
Science. 2011 Oct 7;334(6052):105-8
21885731
Br J Nutr. 2007 May;97(5):993-1000
17381986
Appl Environ Microbiol. 2006 Jul;72(7):5069-72
16820507
Semin Reprod Med. 2009 Sep;27(5):358-68
19711246
Breastfeed Med. 2014 Jun;9(5):266-72
24840853
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14691-6
20679230
Public Health Nutr. 2002 Jun;5(3):487-96
12003662
J Dev Orig Health Dis. 2016 Oct;7(5):440-448
26810498
Am J Clin Nutr. 2007 Dec;86(6):1765-72
18065597
Am J Hum Biol. 2012 May-Jun;24(3):350-60
22378322
Nature. 2012 May 09;486(7402):222-7
22699611
Gut. 2015 Jan;64(1):93-100
25016597
Int J Syst Evol Microbiol. 2008 Apr;58(Pt 4):1008-13
18398210
J Intern Med. 2007 May;261(5):412-7
17444880
Nutr Rev. 2004 May;62(5):177-203
15212319
Am J Clin Nutr. 2014 Mar;99(3):723S-8S
24452235
PLoS One. 2013 Oct 25;8(10):e76341
24204617
Nutrients. 2014 Dec 24;7(1):17-44
25545101
Nutr Rev. 2015 Aug;73 Suppl 1:23-7
26175486
Stat Med. 1990 Jul;9(7):811-8
2218183
Nat Rev Microbiol. 2012 Apr 11;10(5):323-35
22491358
Gut. 2015 Sep 28;:null
26416813
Science. 2016 Apr 29;352(6285):565-9
27126040
MBio. 2014 Sep 30;5(5):e01530-14
25271283
Proc Nutr Soc. 2007 Aug;66(3):423-34
17637095
Am J Clin Nutr. 2014 May;99(5 Suppl):1243S-7S
24646821
Science. 2016 Feb 19;351(6275):null
26912898
Nat Methods. 2010 May;7(5):335-6
20383131
Appl Environ Microbiol. 2014 May;80(9):2889-900
24584251
J Nutr. 2016 Apr;146(4):697-705
26936141
Ir Med J. 2007 Sep;100(8):suppl 27-32
17955698
Epigenomics. 2015 Oct;7(7):1173-84
26585860
Lancet. 2008 Feb 9;371(9611):510-26
18206224
Pediatr Pulmonol. 2012 Dec;47(12 ):1159-69
22628152
Nature. 2014 Jan 23;505(7484):559-63
24336217
Am J Clin Nutr. 2008 Jan;87(1):91-6
18175741
Appl Environ Microbiol. 2005 Dec;71(12):8228-35
16332807
Am J Clin Nutr. 2009 May;89(5):1543S-1548S
19279083
Nat Biotechnol. 2013 Sep;31(9):814-21
23975157
Nat Commun. 2014 Apr 15;5:3654
24736369
Am J Clin Nutr. 2007 Jun;85(6):1626-33
17556702
Sci Transl Med. 2015 Sep 30;7(307):307ra152
26424567
Bioinformatics. 2010 Oct 1;26(19):2460-1
20709691
Cell Rep. 2015 Apr 28;11(4):527-38
25892234
Cell Host Microbe. 2015 May 13;17(5):690-703
25974306
Eur J Clin Nutr. 2004 Jan;58(1):17-23
14679362
Am J Clin Nutr. 2014 May;99(5 Suppl):1248S-50S
24695895
Clin Epigenetics. 2015 Oct 16;7:112
26478753
Br J Nutr. 2007 Jan;97(1):126-33
17217568
Nature. 2004 Jul 22;430(6998):419-21
15269759
Nat Commun. 2015 Mar 25;6:6505
25807110