Determine Multiple Elements Simultaneously in the Sera of Umbilical Cord Blood Samples-a Very Simple Method.
Analyzing the concentrations of heavy metals in the sera of umbilical cord blood samples can provide useful information about prenatal exposure to environmental agents. An analytical method based on ICP-MS to simultaneously determine multiple elements in umbilical cord blood samples was developed for assessing the in utero exposure to metallic and metalloid elements. The method only required as little as 100 μL of serum diluted 1:25 for direct analysis. Matrix-matched protocol was used to eliminate mass matrix interference and kinetic energy discrimination mode was used to eliminate the polyatomic ion interference. The assay was completed on average within 4 min with the detection limits ranging from 0.0002 to 44.4 μg/L for all the targeted elements. The detection rates for most of elements were 100 % other than cadmium (Cd), lead (Pb), and mercury (Hg). The testing results of the certified reference materials were ideal. The method is simple and sensitive, so it is suitable for the monitoring of large quantities of samples.
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, 230021, Anhui Province, People's Republic of China.|Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei, 230021, Anhui Province, People's Republic of China.|Department of Hygiene Analysis and Detection, School of Public Health, Anhui Medical University, Hefei, 230021, Anhui Province, People's Republic of China.
Chunmei
C
Liang
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, 230021, Anhui Province, People's Republic of China.|Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei, 230021, Anhui Province, People's Republic of China.
Zhijuan
Z
Li
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, 230021, Anhui Province, People's Republic of China.|Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei, 230021, Anhui Province, People's Republic of China.|Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui Province, People's Republic of China.
Xun
X
Xia
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, 230021, Anhui Province, People's Republic of China.|Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei, 230021, Anhui Province, People's Republic of China.|Department of toxicology, School of Public Health, Anhui Medical University, Hefei, 230021, Anhui Province, People's Republic of China.
Qunan
Q
Wang
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, 230021, Anhui Province, People's Republic of China.|Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei, 230021, Anhui Province, People's Republic of China.
Ruiwen
R
Tao
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, 230021, Anhui Province, People's Republic of China.|Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei, 230021, Anhui Province, People's Republic of China.
Yiran
Y
Tao
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, 230021, Anhui Province, People's Republic of China.|Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei, 230021, Anhui Province, People's Republic of China.
Haiyun
H
Xiang
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, 230021, Anhui Province, People's Republic of China. s.tong@qut.edu.au.|Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei, 230021, Anhui Province, People's Republic of China. s.tong@qut.edu.au.|School of Public Health and Social Work and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia. s.tong@qut.edu.au.
Shilu
S
Tong
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, 230021, Anhui Province, People's Republic of China. fbtao@126.com.|Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei, 230021, Anhui Province, People's Republic of China. fbtao@126.com.
Fangbiao
F
Tao
D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D019216:Metals, Heavy / Q000097:blood*
D019216:Metals, Heavy
Inductively coupled plasma mass spectrometry; Metalloid; Metals; Serum; Umbilical cord blood