Current techniques for AB0-incompatible living donor liver transplantation.
For a long time, it was considered medical malpractice to neglect the blood group system during transplantation. Because there are far more patients waiting for organs than organs available, a variety of attempts have been made to transplant AB0-incompatible (AB0i) grafts. Improvements in AB0i graft survival rates have been achieved with immunosuppression regimens and plasma treatment procedures. Nevertheless, some grafts are rejected early after AB0i living donor liver transplantation (LDLT) due to antibody mediated rejection or later biliary complications that affect the quality of life. Therefore, the AB0i LDLT is an option only for emergency situations, and it requires careful planning. This review compares the treatment possibilities and their effect on the patients' graft outcome from 2010 to the present. We compared 11 transplant center regimens and their outcomes. The best improvement, next to plasma treatment procedures, has been reached with the prophylactic use of rituximab more than one week before AB0i LDLT. Unfortunately, no standardized treatment protocols are available. Each center treats its patients with its own scheme. Nevertheless, the transplant results are homogeneous. Due to refined treatment strategies, AB0i LDLT is a feasible option today and almost free of severe complications.
Silke Rummler, Heike Jütte, Katrin Maier, Patrice Ziehm, Institute of Transfusion Medicine, University Hospital Jena, 07747 Jena, Germany.
Silke
S
Rummler
Silke Rummler, Heike Jütte, Katrin Maier, Patrice Ziehm, Institute of Transfusion Medicine, University Hospital Jena, 07747 Jena, Germany.
Astrid
A
Bauschke
Silke Rummler, Heike Jütte, Katrin Maier, Patrice Ziehm, Institute of Transfusion Medicine, University Hospital Jena, 07747 Jena, Germany.
Erik
E
Bärthel
Silke Rummler, Heike Jütte, Katrin Maier, Patrice Ziehm, Institute of Transfusion Medicine, University Hospital Jena, 07747 Jena, Germany.
Heike
H
Jütte
Silke Rummler, Heike Jütte, Katrin Maier, Patrice Ziehm, Institute of Transfusion Medicine, University Hospital Jena, 07747 Jena, Germany.
Katrin
K
Maier
Silke Rummler, Heike Jütte, Katrin Maier, Patrice Ziehm, Institute of Transfusion Medicine, University Hospital Jena, 07747 Jena, Germany.
Patrice
P
Ziehm
Silke Rummler, Heike Jütte, Katrin Maier, Patrice Ziehm, Institute of Transfusion Medicine, University Hospital Jena, 07747 Jena, Germany.
Christina
C
Malessa
Silke Rummler, Heike Jütte, Katrin Maier, Patrice Ziehm, Institute of Transfusion Medicine, University Hospital Jena, 07747 Jena, Germany.
Utz
U
Settmacher
AB0-incompatible; Biliary complications; Desensitization; Iso-titer; Living-donor liver transplantation; Rituximab
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