A Water-Soluble Cationic Zinc Lysine Precursor for Coating ZnO on Biomaterial Surfaces.
A novel water-soluble cationic zinc lysine coordination compound, [Zn[(C6H14N2O2)]2Cl]Cl·2H2O (1), has been designed and synthesized and its crystal structure determined. The aqueous solution of this coordination compound is not only transparent and stable at room temperature but it is also nearly neutral (pH ∼ 7). It is worth noting that zinc oxide (ZnO) forms in situ upon dilution of a solution of the compound. The bioactivity of ZnO has been confirmed using an Alarma Blue assay. These unique properties allow the coordination compound to gently grow ZnO coating with excellent antibacterial benefits onto biomaterial surfaces in a facile and safe manner.
Colgate-Palmolive Company , 909 River Road, Piscataway, New Jersey 08854, United States.
Shaotang
S
Yuan
Colgate-Palmolive Company , 909 River Road, Piscataway, New Jersey 08854, United States.
Shiri
S
Nawrocki
Colgate-Palmolive Company , 909 River Road, Piscataway, New Jersey 08854, United States.
Michael
M
Stranick
Colgate-Palmolive Company , 909 River Road, Piscataway, New Jersey 08854, United States.
Ying
Y
Yang
Department of Chemistry and Biochemistry, Northern Illinois University , DeKalb, Illinois 60115, United States.
Chong
C
Zheng
Colgate-Palmolive Company , 909 River Road, Piscataway, New Jersey 08854, United States.
James G
JG
Masters
Colgate-Palmolive Company , 909 River Road, Piscataway, New Jersey 08854, United States.
Long
L
Pan
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D008239:Lysine / Q000737:chemistry* / Q000494:pharmacology; D012867:Skin / Q000737:chemistry; D012995:Solubility; D013211:Staphylococcus aureus / Q000187:drug effects; D013552:Swine; D014867:Water / Q000737:chemistry; D015034:Zinc Oxide / Q000737:chemistry* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D056831:Coordination Complexes; D014867:Water; D008239:Lysine; D015034:Zinc Oxide