Coexistence of lymphoproliferative and myeloproliferative neoplasms with simultaneous CALR and JAK2 V617F mutations.
BACKGROUND
Hematopoietic malignancies are a group of blood cell disorders characterized by abnormal hematopoietic proliferation.


OBJECTIVE
The identification of specific clinicopathologic characteristics and tumor-related gene status provides critical information on potential therapeutic targets.


METHODS
The specimens were tested with immunohistochemistry, flow cytometry, RT-PCR and fragment analysis.


RESULTS
In this study, a patient with a long history of tobacco use was reported with a diagnosis of simultaneous low-grade B-cell lymphoproliferative disorder (LPD) and myeloproliferative neoplasm (MPN). Mutational analysis revealed that JAK2 V617F mutation and CALR mutation with 52bp deletion were present in this patient.


CONCLUSIONS
These results suggest that lymphoproliferative and myeloproliferative neoplasms may coexist, although the pathogenetic mechanism of coexisting hematologic requires further investigation. Additionally, the data indicate that JAK2 V617F and CALR mutations are not mutually exclusive and the actual frequency of simultaneous JAK2 V617F and CALR mutations is unknown. Whether the coexistence of these mutations imposes any biological or clinical significance awaits further investigation.
Hai-Su
HS
Yang
D037282:Calreticulin / Q000235:genetics*; D006801:Humans; D053614:Janus Kinase 2 / Q000235:genetics*; D008232:Lymphoproliferative Disorders / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009196:Myeloproliferative Disorders / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism
D037282:Calreticulin; C507924:JAK2 protein, human; D053614:Janus Kinase 2
CALR; JAK2; Lymphoproliferative neoplasm; MPNs