Does prenatal stress alter the developing connectome?
Human neurodevelopment requires the organization of neural elements into complex structural and functional networks called the connectome. Emerging data suggest that prenatal exposure to maternal stress plays a role in the wiring, or miswiring, of the developing connectome. Stress-related symptoms are common in women during pregnancy and are risk factors for neurobehavioral disorders ranging from autism spectrum disorder, attention deficit hyperactivity disorder, and addiction, to major depression and schizophrenia. This review focuses on structural and functional connectivity imaging to assess the impact of changes in women's stress-based physiology on the dynamic development of the human connectome in the fetal brain.
Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
Dustin
D
Scheinost
Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut.|Department of Child Study, Yale School of Medicine, New Haven, Connecticut.|Department of Neuroscience, Yale School of Medicine, New Haven, Connecticut.
Rajita
R
Sinha
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut.
Sarah N
SN
Cross
Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut.
Soo Hyun
SH
Kwon
Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
Gordon
G
Sze
Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.|Department of Neurosurgery, Yale School of Medicine, New Haven, Connecticut.
R Todd
RT
Constable
Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut.|Department of Neurology, Yale School of Medicine, New Haven, Connecticut.
Laura R
LR
Ment
D001007:Anxiety / Q000503:physiopathology; D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology; D000067877:Autism Spectrum Disorder / Q000503:physiopathology; D001921:Brain / Q000503:physiopathology; D063132:Connectome; D003865:Major Depressive Disorder / Q000503:physiopathology*; D005260:Female; D005315:Fetal Diseases / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000503:physiopathology; D009434:Neural Pathways / Q000503:physiopathology; D011247:Pregnancy; D011248:Pregnancy Complications; D012307:Risk Factors; D013315:Stress, Psychological
Child Dev. 2016 Jan-Feb;87(1):61-72
26822443
PLoS One. 2012;7(6):e39791
22761903
Prog Neurobiol. 2012 Aug;98(2):145-65
22627492
Neuroscience. 2015 Mar 19;289:270-8
25595989
J Child Psychol Psychiatry. 2007 Mar-Apr;48(3-4):245-61
17355398
Front Neurosci. 2014 Feb 05;8:11
24550772
Schizophr Res. 2014 Jan;152(1):158-63
24275580
Behav Brain Res. 2015 Sep 15;291:155-163
26005125
J Neurosci. 2013 Jan 16;33(3):1088-98
23325246
Neurosci Biobehav Rev. 2008 Oct;32(8):1519-32
18598714
Am J Psychiatry. 2016 Feb 1;173(2):147-57
26514656
Cereb Cortex. 2015 Sep;25(9):3132-43
24860018
Early Hum Dev. 2005 Feb;81(2):183-90
15748973
Am J Psychiatry. 2015 Feb 1;172(2):163-72
25320962
Endocrinology. 2015 Oct;156(10):3408-15
26241067
Dev Neurosci. 2011;33(6):531-8
22286693
Psychol Med. 2014 Jan;44(1):71-84
23591021
Nat Commun. 2016 Feb 19;7:10717
26892004
Transl Psychiatry. 2013 Sep 24;3:e306
24064710
Neuroimage Clin. 2016 Aug 10;12:381-8
27622134
Transl Psychiatry. 2014 Mar 11;4:e371
24618690
Int J Dev Neurosci. 2012 Feb;30(1):11-7
22044604
Neuropsychopharmacology. 2015 Aug;40(9):2135-45
25716930
Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1526-33
17264224
Ann N Y Acad Sci. 2008 Oct;1141:105-30
18991954
Pediatr Res. 2006 Jan;59(1):78-82
16327007
Brain Struct Funct. 2016 Mar;221(2):855-63
25395153
Neurobiol Stress. 2015 Jan 1;1:109-115
25530985
Hippocampus. 2015 Feb;25(2):187-96
25214446
Biol Psychiatry. 2013 Nov 1;74(9):647-55
23611262
J Am Acad Child Adolesc Psychiatry. 2010 Mar;49(3):239-47
20410713
Neuroendocrinology. 2012;95(1):7-21
21494029
J Autism Dev Disord. 2013 Jul;43(7):1505-16
23076505
Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5169-74
23487789
Obstet Gynecol. 2007 Nov;110(5):1102-12
17978126
Hum Brain Mapp. 2015 Apr;36(4):1524-35
25523617
J Affect Disord. 2010 Jun;123(1-3):17-29
19635636
Psychol Med. 2016 Apr;46(5):1037-54
26670947
Arch Womens Ment Health. 2013 Feb;16(1):11-8
22936117
Biol Psychiatry. 2015 Feb 15;77(4):324-34
25129235
Anat Histol Embryol. 2008 Apr;37(2):95-100
18333853
Dev Neurosci. 2009;31(1-2):23-35
19372684
Lancet Psychiatry. 2015 Jul;2(7):609-17
26303558
Health Psychol. 1999 Jul;18(4):333-45
10431934
Dev Neurosci. 2015;37(6):533-45
26279160
Front Psychol. 2011 Jan 19;1:223
21833278
Eur Child Adolesc Psychiatry. 2010 Oct;19(10):747-53
20495989
Front Endocrinol (Lausanne). 2014 May 13;5:73
24860550
Dialogues Clin Neurosci. 2013 Sep;15(3):359-84
24174907
BMC Psychiatry. 2008 Aug 21;8:71
18717990
Neurosci Biobehav Rev. 2013 Nov;37(9 Pt B):2220-32
23542738
Neuropsychopharmacology. 2014 Feb;39(3):670-80
24051900
J Womens Health (Larchmt). 2012 Aug;21(8):830-6
22691031
Cereb Cortex. 2017 Jan 1;27(1):534-543
26494796
Arch Gen Psychiatry. 2008 Feb;65(2):146-52
18250252
Stress. 2011 Nov;14(6):665-76
21995526
Neurosci Lett. 2010 Feb 5;470(1):24-7
20035832
Front Psychol. 2016 Feb 12;7:80
26903895
Neuropsychopharmacology. 2015 Jun;40(7):1782-93
25630572
Pediatr Res. 2016 Feb;79(2):339-47
26524714
Gen Hosp Psychiatry. 2009 Sep-Oct;31(5):403-13
19703633
Depress Anxiety. 2015 Feb;32(2):82-90
24788841
Psychiatr Clin North Am. 2002 Jun;25(2):469-94, ix
12136511
Bull World Health Organ. 2012 Feb 1;90(2):139G-149G
22423165
PLoS One. 2012;7(6):e37758
22719848
Neuropsychopharmacology. 2016 Jan;41(1):197-206
26105143
Obstet Gynecol. 2008 Apr;111(4):1001-20
18378767
Dev Neurobiol. 2016 Oct;76(10):1078-91
26724783
Horm Behav. 2012 Aug;62(3):237-42
22465455
Clin Obstet Gynecol. 2009 Sep;52(3):425-40
19661759
J Neuroendocrinol. 2016 Aug;28(8):
26836228
Depress Anxiety. 2014 Jan;31(1):9-18
24395339
Neurosci Biobehav Rev. 2016 Aug;67:9-24
26952805
Psychoneuroendocrinology. 2015 Dec;62:366-75
26372770
Dev Cogn Neurosci. 2015 Feb;11:96-104
25284273
Biol Psychiatry. 2015 Sep 1;78(5):315-26
25863359
Annu Rev Med. 2011;62:461-74
21226617
Dev Psychopathol. 2015 Feb;27(1):137-50
25640836
Proc Natl Acad Sci U S A. 2012 May 15;109(20):E1312-9
22529357
J Steroid Biochem Mol Biol. 2016 Jun;160:175-80
26474822
Neuropharmacology. 2015 Oct;97:251-8
26032436
Biol Psychiatry. 2012 Jul 1;72(1):57-64
22218286
J Am Acad Child Adolesc Psychiatry. 2008 Sep;47(9):1063-72
18665002
J Am Acad Child Adolesc Psychiatry. 2015 Jan;54(1):11-24
25524786
World J Biol Psychiatry. 2014 May;15(4):346-52
24815522
J Dev Orig Health Dis. 2016 Aug;7(4):416-28
26983652
Stress. 2011 Nov;14(6):644-51
21790468
Biol Psychiatry. 2013 Dec 1;74(11):837-44
23968960
Psychopharmacology (Berl). 2011 Mar;214(1):89-106
20949351
Transl Psychiatry. 2015 Feb 17;5:e508
25689569
Neuron. 2014 Sep 17;83(6):1335-53
25233316
Neuropsychopharmacology. 2015 Mar;40(4):996-1004
25315195
J Autism Dev Disord. 2008 Mar;38(3):481-8
17619130
Biol Psychiatry. 2010 Aug 15;68(4):314-9
20674602
Dev Cogn Neurosci. 2015 Apr;12:12-39
25459874
Brain Connect. 2011;1(1):13-36
22432952
Dialogues Clin Neurosci. 2013 Sep;15(3):247-62
24174898
Child Dev. 2010 Jan-Feb;81(1):131-48
20331658
JAMA Psychiatry. 2013 Dec;70(12):1312-9
24108418
J Psychiatr Res. 2008 Oct;42(13):1104-11
18281061
Ann N Y Acad Sci. 2006 Jul;1071:454-8
16891597
J Neurosci. 2005 Sep 7;25(36):8303-10
16148238
J Child Psychol Psychiatry. 2011 Feb;52(2):119-29
20854366
Nurs Res. 2015 Sep-Oct;64(5):331-41
26325275
Neuropsychopharmacology. 2002 Aug;27(2):309-18
12093605
Obstet Gynecol Surv. 2010 Nov;65(11):713-28
21375788
Schizophr Bull. 2009 May;35(3):596-602
18648022
Front Neuroendocrinol. 2014 Aug;35(3):255-71
24705124
Neurosci Biobehav Rev. 2005 Apr;29(2):259-69
15811497
Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6273-8
19329490
Psychoneuroendocrinology. 2012 Jun;37(6):818-26
22001010
Exp Neurol. 2015 Jun;268:10-20
25218020
Proc Natl Acad Sci U S A. 2012 Oct 16;109 Suppl 2:17186-93
23045653
Paediatr Perinat Epidemiol. 2005 Sep;19(5):334-41
16115284
PLoS One. 2013;8(2):e56967
23451123
Pediatr Res. 2016 Jan;79(1-2):127-35
26484619
Endocrinology. 2014 Jul;155(7):2635-46
24797632
J Affect Disord. 2016 Jun;197:125-33
26991367
Psychoneuroendocrinology. 2013 Apr;38(4):509-21
22910687
Eur J Neurosci. 2014 Sep;40(5):2734-43
24862938
Neuron. 2006 Sep 7;51(5):527-39
16950152
Biomed Environ Sci. 2015 Sep;28(9):642-50
26464251
J Neuroendocrinol. 2016 Apr;28(4):
26613552
Obstet Gynecol. 2009 Jan;113(1):142-51
19104370
Nat Rev Neurosci. 2007 Sep;8(9):700-11
17704812
Dev Neurobiol. 2012 Oct;72(10):1272-6
22488761
Physiol Rev. 2015 Jul;95(3):785-807
26109339
Stress. 2011 Nov;14(6):604-13
21790452
Psychoneuroendocrinology. 2010 Jan;35(1):141-53
19674845
Mol Endocrinol. 2016 Jan;30(1):144-54
26606517
Am J Psychiatry. 2016 Jul 1;173(7):705-13
27013342
Psychol Med. 2010 Feb;40(2):335-45
19476689
Psychol Med. 2015;45(12):2533-43
25786412
JAMA Psychiatry. 2014 Aug;71(8):917-25
24920451
Neurosci Biobehav Rev. 2015 Aug;55:211-22
25956253
Int J Dev Neurosci. 2010 Feb;28(1):83-90
19782125
Psychoneuroendocrinology. 2015 Dec;62:204-16
26318631
J Clin Psychiatry. 2014 Oct;75(10):e1142-52
25373125
Neuroimage. 2013 Oct 15;80:489-504
23711536
J Am Acad Child Adolesc Psychiatry. 2015 Apr;54(4):313-21.e2
25791148