Phytosterols and Dementia.
As the aging of the world's population is becoming increasingly serious, dementia-related diseases have become a hot topic in public health research. In recent years, human epidemiological studies have focused on lipid metabolism disorders and dementia. The efficacy of phytosterol intake as a cholesterol-lowering agent has been demonstrated. Phytosterols directly serve as ligands of the nuclear receptors, peroxisome proliferator-activated receptors (PPARs), activating Sirtuin 1 (SIRT-1), which are involved in the regulation of lipid metabolism and the pathogenesis of dementia. Moreover, phytosterols mediate cell and membrane cholesterol efflux or beta amyloid (Aβ) metabolism, which have preventative and therapeutic effects on dementia. Additionally, incorporation of plant sterols in lipid rafts can effectively reduce dietary fat and alter the dietary composition of fiber, fat and cholesterol to regulate appetite and calories. Overall, the objectives of this review are to explore whether phytosterols are a potentially effective target for the prevention of dementia and to discuss a possible molecular mechanism by which phytosterols play a role in the pathogenesis of dementia via the PPARs-SIRT-1 pathway.
Department of Public Health School, Wuhan University of Science & Technology, Wuhan, 430065, China. moment-88@163.com.
Rong
R
Shuang
Department of Public Health School, Wuhan University of Science & Technology, Wuhan, 430065, China.
Xu
X
Rui
Department of Public Health School, Wuhan University of Science & Technology, Wuhan, 430065, China. Li-WF@163.com.
Li
L
Wenfang
D000818:Animals; D000924:Anticholesteremic Agents / Q000737:chemistry / Q000494:pharmacology; D002784:Cholesterol / Q000378:metabolism; D003704:Dementia / Q000517:prevention & control*; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage; D004195:Disease Models, Animal; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects*; D047492:Peroxisome Proliferator-Activated Receptors / Q000378:metabolism; D010840:Phytosterols / Q000737:chemistry / Q000494:pharmacology*; D056564:Sirtuin 1 / Q000378:metabolism
D000924:Anticholesteremic Agents; D004041:Dietary Fats; D047492:Peroxisome Proliferator-Activated Receptors; D010840:Phytosterols; D002784:Cholesterol; C447939:SIRT1 protein, human; D056564:Sirtuin 1
Cholesterol; Dementia; PPARs; Phytosterols; Plant sterols; SIRT-1
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