Treatment options for hypertension in pregnancy and puerperium.
Hypertensive disorders have become increasingly prevalent and complicate an increasing number of pregnancies. Therefore it is essential that the medications used to treat these disorders be well understood. Furthermore the management is complicated by special consideration needed for the physiologic changes of pregnancy as well as the consideration for possible adverse fetal effects. Areas covered: We performed a review of the scientific literature of medications used to treat hypertensive disorders in pregnancy. We reviewed the guidelines used by different societies all over the world. We also discussed the pharmacodynamics, pharmacokinetics and possible adverse effects relating to the antihypertensive medications. Finally, we discussed the long-term maternal implications of these diseases. Expert opinion: Overall, we encourage a step-wise approach to treating hypertensive disorders of pregnancy. While making sure to max out the use of one medications prior to shifting to another. Also, it is imperative not to be aggressive with treatment due to risk of compromising utero-placental blood flow. There is research currently involving biomarkers, nano-medicine and the placenta project with hopes of developing new targeted medications with a good fetal safety profile.
a Department of Obstetrics, Gynecology and Reproductive Sciences , The University of Texas Health Science Center at Houston , Houston , TX , USA.
Farah H
FH
Amro
b Department of Obstetrics, Gynecology and Reproductive Sciences , Division of Maternal Fetal Medicine , Houston , TX , USA.
Hind N
HN
Moussa
b Department of Obstetrics, Gynecology and Reproductive Sciences , Division of Maternal Fetal Medicine , Houston , TX , USA.
Olaide A
OA
Ashimi
b Department of Obstetrics, Gynecology and Reproductive Sciences , Division of Maternal Fetal Medicine , Houston , TX , USA.
Baha M
BM
Sibai
D000959:Antihypertensive Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D005333:Fetus / Q000187:drug effects; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000188:drug therapy* / Q000453:epidemiology; D010920:Placenta / Q000098:blood supply; D049590:Postpartum Period; D017410:Practice Guidelines as Topic; D011247:Pregnancy
D000959:Antihypertensive Agents
Antihypertensives; chronic hypertension; drugs; gestational hypertension; labetalol; methyldopa; nifedipine; preeclampsia; preeclampsia with severe features; pregnancy; teratogenesis