Incidence, hemodynamic, and electrical characteristics of spreading depolarization in a swine model are affected by local but not by intravenous application of magnesium.
The aim was to characterize the effects of magnesium sulfate, using i.v. bolus and local administration, using intrinsic signal imaging, and on electrocorticographic activity during the induction and propagation of spreading depolarizations in the gyrencephalic porcine brain. Local application of magnesium sulfate led to a complete inhibition of spreading depolarizations. One hour after washing out the topical magnesium sulfate, re-incidence of the spreading depolarizations was observed in 50% of the hemispheres. Those spreading depolarizations showed attenuation in hemodynamic characteristics and speed in intrinsic optical signal imaging. The electrical amplitude decreased through electrocorticographic activity. Intravenous magnesium therapy showed no significant effects on spreading depolarization incidence and characteristics.
Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany edgar.santos@med.uni-heidelberg.de dredgarsantos@hotmail.com.
Edgar
E
Santos
Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany.
Fiorella
F
León
Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany.
Humberto
H
Silos
Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany.
Renan
R
Sanchez-Porras
Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque.
C William
CW
Shuttleworth
Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany.
Andreas
A
Unterberg
Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany.
Oliver W
OW
Sakowitz
D000818:Animals; D013181:Cortical Spreading Depression / Q000187:drug effects*; D004195:Disease Models, Animal; D000069280:Electrocorticography; D006439:Hemodynamics; D015994:Incidence; D008274:Magnesium / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D061848:Optical Imaging / Q000379:methods; D013552:Swine
D008274:Magnesium
Animal models; brain imaging; cerebral blood flow measurement; intrinsic optical signal imaging; magnesium; optical imaging; spreading depression
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