The significance of routine biochemical markers in patients with major depressive disorder.
The aim of our study is to examine the levels of routine biochemical markers in patients with major depressive disorder (MDD), and combine multiple biochemical parameters to assess the discriminative power for patients with MDD. We used the Hamilton Depression (HAMD) score to evaluate the severity of depressive symptoms in 228 patients with MDD. The phase of depression severity was between moderate and severe in MDD patients. There were significant differences between MDD patients and healthy controls in alanine transaminase (ALT), urea nitrogen (UN), lactate dehydrogenase (LDH), uric acid (UA), total protein (TP), total bile acid (TBA), creatinine (Cr), total bilirubin (Tbil), direct bilirubin (Dbil) and indirect bilirubin (Ibil), high density lipoprotein-cholesterol (HDL-C), fasting blood-glucose (FBG) and fructosamine (SF). Multivariate analysis showed that UN, FBG, HDL-C, SF, TP, Cr and Tbil remained independently association with MDD. Further, a logit equation was established to identify patients with MDD. The composite markers exhibited an area under the curve of 0.810 with cut-off values of 0.410. Our results suggest the associations between UN, FBG, HDL-C, TP, Cr, Tbil, SF and MDD, use of these routine biochemical markers in combination may contribute to improve the complete management for patients with MDD.
Department of Laboratory Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, No. 18 Zhongshan Er Road, Baise, Guangxi 533000, China.
You-Fan
YF
Peng
Department of Laboratory Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, No. 18 Zhongshan Er Road, Baise, Guangxi 533000, China.
Yang
Y
Xiang
Department of Laboratory Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, No. 18 Zhongshan Er Road, Baise, Guangxi 533000, China.
Ye-Sheng
YS
Wei
World J Biol Psychiatry. 2010 Mar;11(2 Pt 2):314-20
20218795
Pharmacogenomics. 2015 Nov;16(17):1919-29
26556688
J Nerv Ment Dis. 2014 Oct;202(10):759-62
25265267
Eur Neuropsychopharmacol. 2011 Sep;21(9):655-79
21896369
Acta Diabetol. 2015 Feb;52(1):161-6
25026924
JAMA Psychiatry. 2013 Jan;70(1):31-41
22945416
J Psychiatr Res. 1994 Jan-Feb;28(1):57-84
8064641
Oxid Med Cell Longev. 2015;2015:181643
26257839
J Affect Disord. 2013 Sep 5;150(2):384-8
23759278
Eur Psychiatry. 2008 Sep;23(6):413-20
18760907
Clinics (Sao Paulo). 2015 Sep;70(9):628-31
26375565
Psychiatr Pol. 2012 Mar-Apr;46(2):283-94
23214398
Am J Physiol. 1997 May;272(5 Pt 1):E935-40
9176196
Psychiatry Res. 2007 May 30;151(1-2):145-50
17296234
Psychiatry Investig. 2015 Apr;12(2):249-59
25866527
J Clin Lab Anal. 2016 Nov;30(6):982-985
26996761
Antioxid Redox Signal. 2011 Oct 1;15(7):1835-46
21091076
J Clin Endocrinol Metab. 2003 Oct;88(10):4673-6
14557439
Eur Rev Med Pharmacol Sci. 2016;20(4):631-5
26957263
Psychiatr Danub. 2014 Dec;26(4):314-8
25377365
J Psychiatr Res. 2010 Nov;44(15):1052-7
20413130
Curr Pharm Des. 2012;18(36):5890-9
22681168
Curr Psychiatry Rep. 2011 Dec;13(6):467-75
21927805
Clin Chem Lab Med. 2016 Sep 1;54(9):e249-51
26845725
Mol Psychiatry. 2006 Jul;11(7):680-4
16491133
Med Sci Monit. 2015 Jul 10;21:1996-9
26161507
Adv Clin Chem. 2010;50:47-63
20521440
Health Psychol. 2012 Mar;31(2):210-6
22149131
J Affect Disord. 2015 Mar 15;174:165-72
25497474
Arch Biochem Biophys. 1986 May 15;247(1):1-11
3010872
J Neurol Neurosurg Psychiatry. 1960 Feb;23:56-62
14399272
PLoS One. 2014 Feb 28;9(2):e90361
24587338
Clin Chem Lab Med. 2016 Aug 1;54(8):e229-30
26741350
Asia Pac Psychiatry. 2015 Mar;7(1):78-84
24259452
Clin Biochem. 2009 Sep;42(13-14):1368-74
19527700
Metabolism. 2003 Sep;52(9):1167-74
14506623
Inflamm Res. 2012 Aug;61(8):889-97
22643829
Toxicol Mech Methods. 2010 May;20(4):167-74
20397883