Essential Oils Composition and Antimicrobial Activity of Six Conifers Harvested in Lebanon.
The chemical composition and antimicrobial activity of the essential oils (EOs) of six conifers harvested in Lebanon, Abies cilicica, Cupressus sempervirens, Juniperus excelsa, Juniperus oxycedrus, Cedrus libani and Cupressus macrocarpa gold crest, were investigated. The EOs were obtained by hydrodistillation using a Clevenger-type apparatus and characterized by GC and GC/MS analyses. A principal components analysis based on Pearson correlation between essential oils chemical analyses was also conducted. The minimum inhibitory concentrations (MICs) of these essentials oils were determined against a range of bacteria and fungi responsible for cutaneous infections in human, using the broth microdilution technique. The EOs showed the most interesting bioactivity on the dermatophytes species (MIC values 32 - 64 μg/ml). Each of the major compounds of C. macrocarpa as well as an artificial reconstructed EO were tested on Trichophyton rubrum showing a contribution of the minor components to the overall activity.
CNRS - Institut de Chimie des Substances Naturelles, 1 Avenue de la Terrasse, Gif-sur-Yvette, FR-91198.|Department of Agricultural Sciences, Holy Spirit University of Kaslik, Kaslik, Jounieh, B.P. 446, Lebanon.
Layal
L
Fahed
CNRS - Institut de Chimie des Substances Naturelles, 1 Avenue de la Terrasse, Gif-sur-Yvette, FR-91198.|Department of Agricultural Sciences, Holy Spirit University of Kaslik, Kaslik, Jounieh, B.P. 446, Lebanon.
Madona
M
Khoury
CNRS - Institut de Chimie des Substances Naturelles, 1 Avenue de la Terrasse, Gif-sur-Yvette, FR-91198.|Laboratoire de Biodiversité et Biotechnologies Microbiennes (LBBM), Observatoire Oceanologique, UPMC Univ Paris 06, CNRS, Sorbonne Universités, Banyuls/Mer, FR-66650.
Didier
D
Stien
Department of Agricultural Sciences, Holy Spirit University of Kaslik, Kaslik, Jounieh, B.P. 446, Lebanon.
Naïm
N
Ouaini
CNRS - Institut de Chimie des Substances Naturelles, 1 Avenue de la Terrasse, Gif-sur-Yvette, FR-91198.
Véronique
V
Eparvier
Department of Agricultural Sciences, Holy Spirit University of Kaslik, Kaslik, Jounieh, B.P. 446, Lebanon.
Marc
M
El Beyrouthy
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007861:Lebanon; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology*; D064028:Tracheophyta / Q000737:chemistry*; D014249:Trichophyton / Q000187:drug effects* / Q000254:growth & development
D000900:Anti-Bacterial Agents; D009822:Oils, Volatile
Antimicrobial activities; Chemical composition; Conifers; Essential oils; Lebanon