Embelin and Its Role in Chronic Diseases.
Embelia ribes Burm of Myrsinaceae family has been widely used as an herb in the traditional medicine of India. Embelin is an active component extracted from the fruits of Embelia ribes. It has a wide spectrum of biological activities and is not toxic at low dose. This review focuses on the physical-chemical properties and bioactivities of Embelin, as well as its effects on chronic diseases such as tumors, autoimmune inflammatory diseases, parasitic infections, microbial infections, diabetes, obesity, and cardio-cerebral vascular diseases. The underlying mechanisms of the effects are also discussed. As a multiple-targeted therapeutic agent, Embelin has the potential to be used widely for the treatment of a variety of chronic diseases, including malignant tumors.
Division of Gastroenterology and Hepatology, The First Hospital of Lanzhou University, Lanzhou, 730000, Gansu Province, China.
Hong
H
Lu
Division of Gastroenterology and Hepatology, The First Hospital of Lanzhou University, Lanzhou, 730000, Gansu Province, China.
Jun
J
Wang
Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Youxue
Y
Wang
Division of Gastroenterology and Hepatology, The First Hospital of Lanzhou University, Lanzhou, 730000, Gansu Province, China. liang.qiao@sydney.edu.au.|Storr Liver Centre, The Westmead Institute for Medical Research, The University of Sydney at Westmead Hospital, Westmead, NSW, 2145, Australia. liang.qiao@sydney.edu.au.
Liang
L
Qiao
Division of Gastroenterology and Hepatology, The First Hospital of Lanzhou University, Lanzhou, 730000, Gansu Province, China.
Yongning
Y
Zhou
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D001327:Autoimmune Diseases / Q000188:drug therapy; D016227:Benzoquinones / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D002908:Chronic Disease; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology; D009369:Neoplasms / Q000188:drug therapy
D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D016227:Benzoquinones; D007004:Hypoglycemic Agents; C010945:embelin
Anthelmintic activity; Anticancer activity; Antimicrobial activity; Autoimmune inflammatory diseases; Cardio-cerebral vascular diseases; Diabetes; Embelin