Identifying anticancer peptides by using improved hybrid compositions.
Cancer is one of the main causes of threats to human life. Identification of anticancer peptides is important for developing effective anticancer drugs. In this paper, we developed an improved predictor to identify the anticancer peptides. The amino acid composition (AAC), the average chemical shifts (acACS) and the reduced amino acid composition (RAAC) were selected to predict the anticancer peptides by using the support vector machine (SVM). The overall prediction accuracy reaches to 93.61% in jackknife test. The results indicated that the combined parameter was helpful to the prediction for anticancer peptides.
College of Science, Inner Mongolia Agricultural University, Hohhot, 010018, China.
Feng-Min
FM
Li
College of Science, Inner Mongolia Agricultural University, Hohhot, 010018, China.
Xiao-Qian
XQ
Wang
PLoS One. 2010 Jun 28;5(6):e11335
20596258
BMC Bioinformatics. 2014 Apr 28;15:120
24776231
Mol Biosyst. 2013 Apr 5;9(4):634-44
23370050
J Theor Biol. 2015 Nov 21;385:153-9
26362104
Nucleic Acids Res. 2014 Dec 1;42(21):12961-72
25361964
Bioinformatics. 2016 Feb 1;32(3):362-9
26476782
ScientificWorldJournal. 2014;2014:864135
25110749
J Microbiol Methods. 2009 Jul;78(1):94-6
19348863
BMC Struct Biol. 2014 Apr 15;14:13
24731387
PLoS One. 2011 Apr 13;6(4):e18476
21533231
Nature. 1972 May 26;237(5352):232-5
4625204
Bioinformatics. 2014 Feb 15;30(4):472-9
24318998
Nucleic Acids Res. 2009 Jan;37(Database issue):D933-7
18957441
Biophys J. 2003 May;84(5):3257-63
12719255
Amino Acids. 2008 Jan;34(1):119-25
17514493
J Intern Med. 2003 Sep;254(3):197-215
12930229
Biochim Biophys Acta. 2009 Aug;1788(8):1564-9
19041293
J Theor Biol. 2012 Jul 7;304:88-95
22459701
Cancer Res. 2005 Jun 1;65(11):4614-22
15930279
Sci Rep. 2015 Dec 09;5:16964
26648527
J Theor Biol. 2013 Oct 7;334:45-51
23770403
PLoS One. 2015 Mar 30;10(3):e0121501
25821974
Anal Biochem. 2013 May 15;436(2):168-77
23395824
J Theor Biol. 2014 Jan 21;341:34-40
24035842
J Theor Biol. 2007 Apr 21;245(4):775-83
17189644
World J Gastroenterol. 2006 Mar 21;12(11):1694-8
16586536
Bioinformatics. 2014 Jun 1;30(11):1522-9
24504871
Oncotarget. 2016 Mar 29;7(13):16895-909
26942877
CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90
21296855
J Biol Chem. 2002 Nov 29;277(48):45765-9
12186861
Crit Rev Biochem Mol Biol. 1995;30(4):275-349
7587280
Amino Acids. 2012 Aug;43(2):545-55
22102053
Protein Pept Lett. 2008;15(6):612-6
18680458
Proteins. 2005 Mar 1;58(4):923-34
15645428
Nucleic Acids Res. 2013 Apr 1;41(6):e68
23303794