Small mammalian animal models of heart disease.
There is an urgent clinical need to develop new therapeutic approaches for treating cardiovascular disease, but the biology of cardiovascular regeneration is complex. Model systems are required to advance our understanding of the pathogenesis, progression, and mechanisms underlying cardiovascular disease as well as to test therapeutic approaches to regenerate tissue and restore cardiac function following injury. An ideal model system should be inexpensive, easily manipulated, reproducible, physiologically representative of human disease, and ethically sound. The choice of animal model needs to be considered carefully since it affects experimental outcomes and whether findings of the study can be reasonably translated to humans. This review presents a guideline for the commonly used small animal models (mice, rats, rabbits, and cats) used in cardiac research as an effort to standardize the most relevant procedures and obtain translatable and reproducible results.
Department of Biomedical Sciences and Pathobiology, Center for Veterinary Regenerative Medicine, College of Veterinary Medicine, Virginia Polytechnic Institute and State University Blacksburg, VA, 24061, USA.
Paula
P
Camacho
Research Institute of Heart Failure, Shanghai East Hospital of Tongji University Shanghai, 200120, P. R. China.
Huimin
H
Fan
Research Institute of Heart Failure, Shanghai East Hospital of Tongji University Shanghai, 200120, P. R. China.
Zhongmin
Z
Liu
Department of Biomedical Sciences and Pathobiology, Center for Veterinary Regenerative Medicine, College of Veterinary Medicine, Virginia Polytechnic Institute and State University Blacksburg, VA, 24061, USA.
Jia-Qiang
JQ
He
Mouse; cat; diabetic cardiomyopathy; heart failure; myocardial infarction; rabbit; rat
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