Dengue scenario: Chennai perspective-a six-year study (2009-2014).
Dengue is a public health problem with an increasing global incidence and geographic distribution in almost all tropical and subtropical countries, with a transition from epidemic to endemic occurrence. In this study, we report a six-year analysis (2009-2014) performed at the Department of Virology, King Institute of Preventive Medicine, Chennai, Tamil Nadu, India. Our data confirm earlier findings that dengue is highly endemic in Chennai. In the present study, 10,099 serum samples from suspected dengue cases were tested for IgM ELISA (NIV Capture) and IgG Panbio ELISA (Australia). Of these suspected cases 6,798 and 3,301 were pediatric and adult cases, respectively, and 1,927 (19.08 %) were confirmed serologically as dengue. Of these, 1,752 (25.7 %) and 175 (5.3 %) were pediatric and adult cases, respectively. The aim of this study was to highlight the occurrence of DHF and DSS, mainly among the pediatric population, in which the infection causes higher mortality and morbidity. The overall positivity was higher in the pediatric group than in the adults. Detection of both IgM and IgG positivity will be useful for monitoring infection rates, the disease spectrum, and the prevalence of the different serotypes, which will give us insight about the circulating serotypes and pathogenicity. These data will be valuable for providing an early warning to predict an impending epidemic leading to major clinical manifestations of DHF and DSS.
Bioproducts Lab, CSIR-Central Leather Research Institute, Adyar, Chennai, 600 032, India.|Department of Virology, King Institute of Preventive Medicine and Research, Guindy, Chennai, Tamilnadu, 600032, India.
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Padmapriya
Department of Virology, King Institute of Preventive Medicine and Research, Guindy, Chennai, Tamilnadu, 600032, India.
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Senthil Kumar
Department of Virology, King Institute of Preventive Medicine and Research, Guindy, Chennai, Tamilnadu, 600032, India.
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Senthil Raja
Department of Virology, King Institute of Preventive Medicine and Research, Guindy, Chennai, Tamilnadu, 600032, India.
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Khaleefathullah Sheriff
Bioproducts Lab, CSIR-Central Leather Research Institute, Adyar, Chennai, 600 032, India.
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Uma
Department of Virology, King Institute of Preventive Medicine and Research, Guindy, Chennai, Tamilnadu, 600032, India.
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Mohana
Department of Virology, King Institute of Preventive Medicine and Research, Guindy, Chennai, Tamilnadu, 600032, India.
Kavita
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Arunagiri
Department of Virology, King Institute of Preventive Medicine and Research, Guindy, Chennai, Tamilnadu, 600032, India.
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Anupama
Department of Virology, King Institute of Preventive Medicine and Research, Guindy, Chennai, Tamilnadu, 600032, India.
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Saran
Department of Virology, King Institute of Preventive Medicine and Research, Guindy, Chennai, Tamilnadu, 600032, India.
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Kiruba
Department of Virology, King Institute of Preventive Medicine and Research, Guindy, Chennai, Tamilnadu, 600032, India.
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Saravana Murali
Department of Virology, King Institute of Preventive Medicine and Research, Guindy, Chennai, Tamilnadu, 600032, India.
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Suresh Babu
Department of Virology, King Institute of Preventive Medicine and Research, Guindy, Chennai, Tamilnadu, 600032, India.
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Nivas Chakravarthy
Department of Virology, King Institute of Preventive Medicine and Research, Guindy, Chennai, Tamilnadu, 600032, India.
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Saraswathi
Department of Virology, King Institute of Preventive Medicine and Research, Guindy, Chennai, Tamilnadu, 600032, India. kaveriraj1967@gmail.com.
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Kaveri
Department of Virology, King Institute of Preventive Medicine and Research, Guindy, Chennai, Tamilnadu, 600032, India.
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Gunasekaran
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003715:Dengue / Q000453:epidemiology* / Q000473:pathology*; D019353:Endemic Diseases; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007194:India / Q000453:epidemiology; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D055815:Young Adult
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M