Evaluation of Knee Proprioception and Factors Related to Parkinson's Disease.
Background. Changes in proprioception may contribute to postural instability in individuals with neurological disorders. Objectives. Evaluate proprioception in the lower limbs of patients with Parkinson's disease (PD) and the association between proprioception and cognitive ability, motor symptoms, postural instability, and disease severity. Methods. This is a cross-sectional, controlled study that evaluated proprioception in PD patients and healthy age- and sex-matched individuals. Kinetic postural proprioception of the knee was evaluated using an isokinetic dynamometer (Biodex® Multi-Joint System 4 Pro). Participants were evaluated using the Montreal Cognitive Assessment (MoCA), the Hoehn and Yahr rating scale and postural instability (pull test and stabilometric analysis), and motor function (UPDRS-III) tests. Results. A total of 40 individuals were enrolled in the study: 20 PD patients and 20 healthy controls (CG). The PD patients had higher angular errors on the proprioceptive ratings than the CG participants (p = 0.002). Oscillations of the center of pressure (p = 0.002) were higher in individuals with PD than in the controls. Proprioceptive errors in the PD patients were associated with the presence of tremors as the dominant symptom and more impaired motor performance. Conclusion. These findings show that individuals with PD have proprioceptive deficits, which are related to decreased cognitive ability and impaired motor symptoms.
Postgraduation Program in Medical Sciences, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Paulo Gama 110, 90040-060 Porto Alegre, RS, Brazil.
Nathalie
0000-0001-7204-9485
N
Ribeiro Artigas
Postgraduation Program in Technology and Human Development, Universidade Estadual Paulista (UNESP), R. Quirino de Andrade 215, 01049-010 São Paulo, SP, Brazil.
Giovana Duarte
GD
Eltz
Technological and Industrial Development FAPERGS/CAPES, Department of Physiotherapy, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), R. Sarmento Leite 245, 90050-170 Porto Alegre, RS, Brazil.
Alexandre Severo
0000-0003-4818-8244
AS
do Pinho
Statistic, Statistic Department, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
Vanessa Bielefeldt Leotti
VB
Torman
Neurology, Clinical Medicine Department, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil.
Arlete
0000-0003-1476-2105
A
Hilbig
Neurology, Clinical Medicine Department, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA) and Postgraduation Program in Medical Science, UFRGS, Porto Alegre, RS, Brazil.
Carlos R M
0000-0003-2950-7211
CR
Rieder
J Neurol. 2006 Feb;253(2):199-207
16222427
Neurology. 1967 May;17(5):427-42
6067254
Arch Neurol. 1997 Apr;54(4):450-4
9109747
Neuroscience. 2006 Aug 25;141(2):999-1009
16713110
Clin Anat. 2002 Jan;15(1):23-31
11835540
Mov Disord. 2011 Mar;26(4):637-43
21312283
J Orthop Res. 2005 Jan;23(1):46-53
15607874
Neurophysiol Clin. 2008 Dec;38(6):459-65
19026965
Neuroscience. 2001;104(4):1027-41
11457588
Neuroscience. 2009 Jan 23;158(2):426-40
18996173
Neuroscience. 2009 Feb 18;158(4):1206-14
19136043
Clin Orthop Relat Res. 2002 Sep;(402):76-94
12218474
Expert Rev Neurother. 2013 Dec;13(12):1303-8
24160682
J Am Geriatr Soc. 2005 Apr;53(4):695-9
15817019
J Neurol Neurosurg Psychiatry. 2001 Nov;71(5):607-10
11606670
J Neurol. 2007 May;254(5):655-63
17420926
J Neurol Neurosurg Psychiatry. 1999 Oct;67(4):504-10
10486399
Eur J Neurosci. 2005 Jan;21(1):239-48
15654861
Parkinsonism Relat Disord. 2004 Dec;10(8):501-6
15542011
Ann Neurol. 2002 Nov;52(5):581-7
12402255
Exp Neurol. 2011 Jan;227(1):26-30
21087607
J Neurol Neurosurg Psychiatry. 2008 Apr;79(4):368-76
18344392
Parkinsonism Relat Disord. 2007 Oct;13(7):425-33
17446116
Rheumatol Int. 2012 Dec;32(12):3793-8
22187058
Neurol Sci. 2012 Dec;33(6):1215-23
22673818
Neuroscience. 2007 May 11;146(2):852-63
17367947
Neurorehabil Neural Repair. 2014 Mar-Apr;28(3):282-90
24243915
Neurosci Lett. 2006 Jun 19;401(1-2):92-6
16574321