Self-Assembly of Amphiphilic Block Copolypeptoids - Micelles, Worms and Polymersomes.
Polypeptoids are an old but recently rediscovered polymer class with interesting synthetic, physico-chemical and biological characteristics. Here, we introduce new aromatic monomers, N-benzyl glycine N-carboxyanhydride and N-phenethyl glycine N-carboxyanhydride and their block copolymers with the hydrophilic polysarcosine. We compare their self-assembly in water and aqueous buffer with the self-assembly of amphiphilic block copolypeptoids with aliphatic side chains. The aggregates in water were investigated by dynamic light scattering and electron microscopy. We found a variety of morphologies, which were influenced by the polymer structure as well as by the preparation method. Overall, we found polymersomes, worm-like micelles and oligo-lamellar morphologies as well as some less defined aggregates of interconnected worms and vesicles. Such, this contribution may serve as a starting point for a more detailed investigation of the self-assembly behavior of the rich class of polypeptoids and for a better understanding between the differences in the aggregation behavior of non-uniform polypeptoids and uniform peptoids.
Functional Polymer Materials, Chair for Chemical Technology of Materials Synthesis, University Würzburg, Röntgenring 11, 97070 Würzburg, Germany.
Corinna
C
Fetsch
Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, United Kingdom.|Department of Chemistry, University of Basel, Klingelbergstrasse 80, 4056 Basel, Basel-Stadt, Switzerland.
Jens
J
Gaitzsch
Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, United Kingdom.
Lea
L
Messager
Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, United Kingdom.
Giuseppe
G
Battaglia
Functional Polymer Materials, Chair for Chemical Technology of Materials Synthesis, University Würzburg, Röntgenring 11, 97070 Würzburg, Germany.
Robert
R
Luxenhofer
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