The metabolome 18 years on: a concept comes of age.
BACKGROUND
The term 'metabolome' was introduced to the scientific literature in September 1998.
To mark its 18-year-old 'coming of age', two of the co-authors of that paper review the genesis of metabolomics, whence it has come and where it may be going.
School of Chemistry, The University of Manchester, 131 Princess St, Manchester, M1 7DN UK ; Manchester Institute of Biotechnology, The University of Manchester, 131 Princess St, Manchester, M1 7DN UK ; Centre for Synthetic Biology of Fine and Speciality Chemicals (SYNBIOCHEM), The University of Manchester, 131, Princess St, Manchester, M1 7DN UK.
Douglas B
DB
Kell
Cambridge Systems Biology Centre, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge, CB2 1GA UK ; Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge, CB2 1GA UK.
Stephen G
SG
Oliver
Functional genomics; Metabolome; Precision medicine; Systems biology
Org Biomol Chem. 2005 May 21;3(10):1832-4
15889163
Metabolomics. 2015;11:9-26
25598764
J Chromatogr A. 2015 Sep 18;1412:43-51
26292625
Metabolomics. 2016;12:14
26612985
Anal Chem. 2009 Aug 15;81(16):7038-46
19606840
Environ Health Perspect. 2014 Aug;122(8):769-74
24659601
Nat Biotechnol. 2004 Dec;22(12):1601-6
15583675
J Cheminform. 2013 Jan 24;5(1):7
23343401
FEMS Microbiol Rev. 2015 Jul;39(4):567-91
25940667
Trends Biotechnol. 2004 May;22(5):245-52
15109811
Trends Biotechnol. 2015 Apr;33(4):237-46
25746161
Pflugers Arch. 2004 Feb;447(5):465-8
14624363
Front Pharmacol. 2016 Aug 22;7:266
27597830
Anal Chem. 2016 Sep 20;88(18):9004-13
27479709
J Biochem Mol Biol. 2004 Jan 31;37(1):93-106
14761307
Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3698-703
19234110
Nat Biotechnol. 2000 Nov;18(11):1157-61
11062433
Bioinformatics. 2015 Aug 15;31(16):2757-60
25847005
Metabolomics. 2007 Sep;3(3):211-221
24039616
Biotechnol J. 2013 Sep;8(9):1017-34
24031036
BMC Bioinformatics. 2007 Mar 27;8:105
17389044
PLoS Med. 2005 Aug;2(8):e124
16060722
Anal Chem. 2005 Jan 1;77(1):290-303
15623308
Eur J Biochem. 1974 Feb 15;42(1):89-95
4830198
Nature. 1996 Feb 15;379(6566):597-600
8628394
Anal Chem. 2006 Apr 1;78(7):2113-20
16579588
Cell. 2015 Jul 30;162(3):478-87
26232220
Drug Discov Today. 2011 Aug;16(15-16):704-14
21624498
Nat Biotechnol. 2003 Jun;21(6):692-6
12740584
Nat Biotechnol. 2007 Aug;25(8):846-8
17687353
Nat Protoc. 2011 Jun 30;6(7):1060-83
21720319
Nat Biotechnol. 2008 Oct;26(10):1155-60
18846089
Proc Natl Acad Sci U S A. 1983 Jan;80(1):305-9
6572006
PeerJ. 2015 Nov 17;3:e1405
26618081
Bioessays. 2004 Jan;26(1):99-105
14696046
Anal Chem. 2009 Feb 15;81(4):1357-64
19170513
Analyst. 2002 Nov;127(11):1457-62
12475034
Curr Top Med Chem. 2009;9(2):163-81
19200003
F1000Res. 2015 Jul 01;4:179
26629334
J Gen Microbiol. 1988 Jul;134(7):1901-11
3246590
Metabolomics. 2016;12:109
27358602
Bioinformatics. 2015 Mar 15;31(6):975-7
25388146
Adv Appl Microbiol. 1961;3:293-342
13874183
Biochem J. 1992 Sep 1;286 ( Pt 2):313-30
1530563
Surg Endosc. 2017 Mar;31(3):1361-1370
27501728
Methods Mol Biol. 2013;985:149-73
23417804
Drug Discov Today. 2006 Dec;11(23-24):1085-92
17129827
Nature. 2016 Jul 06;535(7610):75-84
27383982
Anal Chem. 2001 Sep 1;73(17):4134-44
11569802
Nucleic Acids Res. 2006 Jan 1;34(Database issue):D442-5
16381907
Cell. 2016 Mar 10;164(6):1185-1197
26967285
Nature. 2001 Feb 1;409(6820):571-2
11214302
Nat Biotechnol. 2001 Jan;19(1):45-50
11135551
Trends Biotechnol. 2014 Oct;32(10):538-48
25179940
Front Plant Sci. 2012 Feb 10;3:15
22645570
Biochem J. 1966 Dec;101(3):792-810
16742460
Metabolomics. 2015;11(6):1587-1597
26491418
Nature. 2016 Jan 28;529(7587):484-9
26819042
Chem Soc Rev. 2015 Mar 7;44(5):1172-239
25503938
Nucleic Acids Res. 2013 Jan;41(Database issue):D781-6
23109552
Nat Chem Biol. 2014 Sep;10(9):768-773
25064833
Nat Biotechnol. 2013 May;31(5):419-25
23455439
Appl Environ Microbiol. 2004 Oct;70(10):6157-65
15466562
Nat Protoc. 2009;4(6):878-92
19478804
BMC Biol. 2011 Oct 24;9:70
22023736
Nucleic Acids Res. 2012 Jan;40(Database issue):D815-20
22064855
Anal Chem. 2011 May 15;83(10):3737-43
21466230
Nature. 2004 Jan 15;427(6971):247-52
14724639
Mutagenesis. 2015 Nov;30(6):755-62
26290610
Nat Rev Microbiol. 2005 Jul;3(7):557-65
15953932
Trends Biotechnol. 1998 Sep;16(9):373-8
9744112
Drug Discov Today. 2013 Mar;18(5-6):218-39
23207804
Mass Spectrom Rev. 2007 Jan-Feb;26(1):51-78
16921475
Nat Methods. 2015 Nov;12(11):1091-7
26366986
J Antibiot (Tokyo). 2010 Aug;63(8):468-76
20648021
J Biol Chem. 1955 Nov;217(1):409-27
13271404
Hypertension. 2010 Oct;56(4):741-9
20837882
Genetics. 1981 Mar-Apr;97(3-4):639-66
7297851
Clin Chem. 1971 Aug;17(8):802-9
5105517
Philos Trans R Soc Lond B Biol Sci. 2006 Jan 29;361(1465):147-61
16553314
J Cheminform. 2013 Mar 13;5(1):14
23497723
Genome Biol. 2007;8(10):R223
17949488
Analyst. 2009 Jul;134(7):1322-32
19562197
Biotechnology (N Y). 1996 Jan;14(1):61-5
9636313
Curr Opin Microbiol. 2004 Jun;7(3):296-307
15196499
Comp Funct Genomics. 2003;4(4):376-91
18629082
Trends Pharmacol Sci. 2015 Nov;36(11):710-723
26538313
Trends Pharmacol Sci. 2015 Jan;36(1):15-21
25458537
BMC Bioinformatics. 2011 Aug 04;12:321
21816034
Science. 1996 Oct 25;274(5287):546, 563-7
8849441
Plant Mol Biol. 2002 Jan;48(1-2):155-71
11860207
Nature. 1992 May 7;357(6373):38-46
1574125
J Cheminform. 2015 Aug 28;7:44
26322134
Science. 2006 Mar 17;311(5767):1566-70
16543450
Nature. 2000 Feb 10;403(6770):601-3
10688178
Nucleic Acids Res. 2013 Jan;41(Database issue):D801-7
23161693
Nucleic Acids Res. 2014 Jul;42(Web Server issue):W389-94
24792156
Microbiology (Reading). 1998 May;144 ( Pt 5):1157-1170
9611790
Front Pharmacol. 2014 Oct 31;5:231
25400580
Nature. 2011 Apr 7;472(7341):57-63
21475195
Gigascience. 2013 Oct 16;2(1):13
24131531
Nature. 2015 Feb 26;518(7540):529-33
25719670
Nat Protoc. 2013 Mar;8(3):451-60
23391889
Nat Rev Drug Discov. 2008 Mar;7(3):205-20
18309312
Metabolomics. 2015;11(2):323-339
25750602
Science. 2009 Apr 3;324(5923):85-9
19342587
Front Pharmacol. 2015 May 13;6:105
26029108
Nat Biotechnol. 2015 Mar;33(3):296-300
25485618
Drug Discov Today. 2009 Jan;14(1-2):31-40
19049901
Gigascience. 2015 Mar 26;4:12
25815165
Sci Transl Med. 2013 Jul 17;5(194):194ra93
23863833
J Biol. 2007;6(2):4
17439666
J Gen Microbiol. 1987 Feb;133(2):259-66
2821163
FEBS J. 2013 Dec;280(23):5957-80
23552054
J R Soc Interface. 2015 Mar 6;12(104):20141289
25652463