A novel chitosan-polyethylene oxide nanofibrous mat designed for controlled co-release of hydrocortisone and imipenem/cilastatin drugs.
Antimicrobial chitosan-polyethylene oxide (CS-PEO) nanofibrous mats containing ZnO nanoparticles (NPs) and hydrocortisone-imipenem/cilastatin-loaded ZnO NPs were produced by electrospinning technique. The FE-SEM images displayed that the spherical ZnO NPs were ∼70-200nm in size and the CS-PEO nanofibers were very uniform and free of any beads which had average diameters within the range of ∼20-130nm. For all of the nanofibrous mats, the water uptakes were the highest in acidic medium but they were decreased in the buffer and the least swellings were obtained in the alkaline environment. The drug incorporated mat preserved its bactericidal activity even after it was utilized in the release experiment for 8days in the PBS buffer. The hydrocortisone release was increased to 82% within first 12h while the release rate of imipenem/cilastatin was very much slower so that 20% of the drug was released during this period of time suggesting this nanofibrous mat is very suitable to inhibit inflammation (by hydrocortisone) and infection (using imipenem/cilastatin antibiotic and ZnO NPs) principally for the wound dressing purposes.
Department of Chemistry, Amirkabir University of Technology (Tehran Polytechnic), P.O. Box: 15875-4413, Tehran, Iran.
Yousef
Y
Fazli
Department of Chemistry, Amirkabir University of Technology (Tehran Polytechnic), P.O. Box: 15875-4413, Tehran, Iran. Electronic address: shariati@aut.ac.ir.
Zahra
Z
Shariatinia
Department of Chemistry, Amirkabir University of Technology (Tehran Polytechnic), P.O. Box: 15875-4413, Tehran, Iran; Department of Physiology and Pharmacology, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Iraj
I
Kohsari
Department of Mining & Metallurgical Engineering, Amirkabir University of Technology (Tehran Polytechnic), P.O. Box: 15875-4413, Tehran, Iran.
Amirreza
A
Azadmehr
Faculty of Material and Manufacturing Technologies, Malek Ashtar University of Technology, P.O. Box 16765-3454, Tehran, Iran.
Seied Mahdi
SM
Pourmortazavi
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000737:chemistry; D048271:Chitosan / Q000008:administration & dosage / Q000737:chemistry; D015377:Cilastatin / Q000008:administration & dosage / Q000737:chemistry; D000077728:Cilastatin, Imipenem Drug Combination; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry; D004338:Drug Combinations; D016503:Drug Delivery Systems; D065546:Drug Liberation; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D006854:Hydrocortisone / Q000008:administration & dosage / Q000737:chemistry; D015378:Imipenem / Q000008:administration & dosage / Q000737:chemistry; D057139:Nanofibers / Q000008:administration & dosage / Q000737:chemistry; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D015034:Zinc Oxide / Q000008:administration & dosage / Q000737:chemistry
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D015377:Cilastatin; D011092:Polyethylene Glycols; D015378:Imipenem; D048271:Chitosan; D000077728:Cilastatin, Imipenem Drug Combination; D015034:Zinc Oxide; D006854:Hydrocortisone
Antimicrobial activity; Chitosan–polyethylene oxide nanofibrous mat; Electrospinning; Hydrocortisone; Imipenem/cilastatin; Zinc oxide nanoparticles