Association of Fasciola hepatica Infection with Liver Fibrosis, Cirrhosis, and Cancer: A Systematic Review.
BACKGROUND
Fascioliasis has been sporadically associated with chronic liver disease on previous studies. In order to describe the current evidence, we carried out a systematic review to assess the association between fascioliasis with liver fibrosis, cirrhosis and cancer.


RESULTS
A systematic search of electronic databases (PubMed, LILACS, Scopus, Embase, Cochrane, and Scielo) was conducted from June to July 2015 and yielded 1,557 published studies. Among 21 studies that met inclusion and exclusion criteria, 12 studies explored the association of F. hepatica with liver fibrosis, 4 with liver cirrhosis, and 5 with cancer. Globally these studies suggested the ability of F. hepatica to promote liver fibrosis and cirrhosis. The role of F. hepatica in cancer is unknown. Given the heterogeneity of the studies, a meta-analysis could not be performed.


CONCLUSIONS
Future high-quality studies are needed to determine the role of F. hepatica on the development of liver fibrosis, liver cirrhosis, and cancer in humans.
Cancer Genomics and Epigenomics Laboratory, Department of Cellular and Molecular Sciences, School of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru.|Institute for Biocomputation and Physics of Complex Systems, University of Zaragoza, Spain.
Claudia
C
Machicado
Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America.
Jorge D
JD
Machicado
Laboratorio de Parasitologia, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru.
Vicente
V
Maco
Laboratorio de Parasitologia, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru.
Angelica
A
Terashima
Laboratorio de Parasitologia, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru.|Division of Infectious Diseases, Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America; Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, United States of America.
Luis A
LA
Marcos
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