Animal models for glucocorticoid-induced postmenopausal osteoporosis: An updated review.
Glucocorticoid-induced postmenopausal osteoporosis is a severe osteoporosis, with high risk of major osteoporotic fractures. This severe osteoporosis urges more extensive and deeper basic study, in which suitable animal models are indispensable. However, no relevant review is available introducing this model systematically. Based on the recent studies on GI-PMOP, this brief review introduces the GI-PMOP animal model in terms of its establishment, evaluation of bone mass and discuss its molecular mechanism. Rat, rabbit and sheep with their respective merits were chosen. Both direct and indirect evaluation of bone mass help to understand the bone metabolism under different intervention. The crucial signaling pathways, miRNAs, osteogenic- or adipogenic- related factors and estrogen level may be the predominant contributors to the development of glucocorticoid-induced postmenopausal osteoporosis.
The First School of Clinic Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. Electronic address: spinezzd@sina.com.
Zhida
Z
Zhang
The First School of Clinic Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. Electronic address: renhuispine@163.com.
Hui
H
Ren
The First School of Clinic Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Gengyang
G
Shen
The First School of Clinic Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Ting
T
Qiu
Department of Spinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
De
Liang
Department of Spinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Zhidong
Z
Yang
Department of Spinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Zhensong
Z
Yao
Department of Spinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Jingjing
J
Tang
Department of Spinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China; Laboratory Affiliated to National Key Discipline of Orthopaedic and Traumatology of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. Electronic address: spinedrjxb@sina.com.
Xiaobing
X
Jiang
The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Qiushi
Q
Wei
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D008954:Models, Biological; D015663:Osteoporosis, Postmenopausal / Q000139:chemically induced*; D010052:Ovariectomy; D015398:Signal Transduction
D005938:Glucocorticoids
Animal; Combined; Glucocorticoid-induced postmenopausal osteoporosis