Immunity against influenza A(H1N1) infections is determined by age at the time of initial strain circulation.
We explored age-dependent patterns in haemagglutination inhibition (HI) titre to seasonal [1956 A(H1N1), 1977 A(H1N1), 2007 A(H1N1)] and pandemic [A(H1N1)pdm09] influenza strains using serological data collected from an adult French influenza cohort. Subjects were recruited by their general practitioners from 2008 to 2009 and followed until 2010. We explored age-related differences between strain-specific HI titres using 1053 serological samples collected over the study period from 398 unvaccinated subjects. HI titres against the tested seasonal and pandemic strains were determined using the HI technique. Geometric mean titres (GMTs) were estimated using regression models for interval-censored data. Generalized additive mixed models were fit to log-transformed HI estimates to study the relationship between HI titre and age (age at inclusion and/or age at initial strain circulation). GMT against one strain was consistently highest in the birth cohort exposed to that strain during childhood, with peak titres observed in subjects aged 7-8 years at the time of initial strain circulation. Our results complete previous findings on influenza A(H3N2) strains and identify a strain-dependent relationship between HI titre and age at initial strain circulation.
Sorbonne Universités, UPMC Univ Paris 06,INSERM, Institut Pierre Louis d'épidémiologie et de Santé Publique (IPLESP UMRS 1136),Paris,France.
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RM
Delabre
Emergence des pathologies Virales,UMR-D 190,Aix-Marseille Université and Institut de Recherche pour le Développement,Marseille,France.
N
N
Salez
Sorbonne Universités, UPMC Univ Paris 06,INSERM, Institut Pierre Louis d'épidémiologie et de Santé Publique (IPLESP UMRS 1136),Paris,France.
N
N
Lapidus
National Agency for the Safety of Medicine and Health Products,St Denis,France.
M
M
Lemaitre
Université Paris Descartes,Sorbonne Paris Cité,EA 7328,Paris,France.
M
M
Leruez-Ville
Emergence des pathologies Virales,UMR-D 190,Aix-Marseille Université and Institut de Recherche pour le Développement,Marseille,France.
X
X
de Lamballerie
Sorbonne Universités, UPMC Univ Paris 06,INSERM, Institut Pierre Louis d'épidémiologie et de Santé Publique (IPLESP UMRS 1136),Paris,France.
F
F
Carrat
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood*; D015331:Cohort Studies; D005260:Female; D005602:France; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D055815:Young Adult
D000914:Antibodies, Viral
Antibodies; H1N1 subtype; cohort studies; immunity; influenza; influenza A virus
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