Vesicular Nucleo-Cytoplasmic Transport-Herpesviruses as Pioneers in Cell Biology.
Herpesviruses use a vesicle-mediated transfer of intranuclearly assembled nucleocapsids through the nuclear envelope (NE) for final maturation in the cytoplasm. The molecular basis for this novel vesicular nucleo-cytoplasmic transport is beginning to be elucidated in detail. The heterodimeric viral nuclear egress complex (NEC), conserved within the classical herpesviruses, mediates vesicle formation from the inner nuclear membrane (INM) by polymerization into a hexagonal lattice followed by fusion of the vesicle membrane with the outer nuclear membrane (ONM). Mechanisms of capsid inclusion as well as vesicle-membrane fusion, however, are largely unclear. Interestingly, a similar transport mechanism through the NE has been demonstrated in nuclear export of large ribonucleoprotein complexes duringDrosophilaneuromuscular junction formation, indicating a widespread presence of a novel concept of cellular nucleo-cytoplasmic transport.
Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, 17493 Greifswald-Insel Riems, Germany. thomas.mettenleiter@fli.de.
Thomas C
TC
Mettenleiter
herpesvirus; nuclear egress; nuclear egress complex; nucleo-cytoplasmic transport
J Virol. 2011 Aug;85(15):7513-22
21632758
Trends Cell Biol. 2012 Oct;22(10):509-14
22858153
Nat Struct Mol Biol. 2016 Jun;23 (6):531-9
27111889
J Virol. 2015 Sep;89(18):9150-3
26109725
J Biol Chem. 2015 Mar 13;290(11):6962-74
25605719
J Virol. 2015 Aug;89(16):8444-52
26041288
J Virol. 2015 Aug;89(15):7799-812
25995262
J Virol. 2011 Oct;85(19):9667-79
21775450
J Virol. 2008 Jul;82(13):6299-309
18417564
Nat Commun. 2014 Jun 11;5:4131
24916797
Arch Virol. 2009;154(1):171-7
19066710
Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10187-92
17548810
Curr Opin Cell Biol. 2016 Feb;38:1-11
26775243
Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7241-6
17426144
J Biol Chem. 2015 Nov 13;290(46):27452-8
26432641
Nucleus. 2010 Nov-Dec;1(6):487-91
21327091
J Virol. 2010 Jul;84(14 ):7005-17
20484513
EMBO J. 2015 Dec 2;34(23 ):2921-36
26511020
Virus Res. 2009 Aug;143(2):222-34
19651457
J Virol. 2012 Jan;86(1):594-8
22013050
Science. 2012 May 18;336(6083):809-10
22605737
Curr Opin Cell Biol. 2016 Aug;41:125-31
27236823
Cell Rep. 2013 Apr 25;3(4):988-95
23583177
Cell Host Microbe. 2013 Sep 11;14(3):232-41
24034610
Cell. 2015 Dec 17;163(7):1692-701
26687357
EMBO J. 2015 Dec 2;34(23 ):2937-52
26511021
J Mol Biol. 2016 May 22;428(10 Pt A):1949-61
26522933
Viruses. 2012 May;4(5):800-32
22754650
Adv Virus Res. 2015;93:161-256
26111587
Curr Drug Targets. 2007 Oct;8(10):1084-95
17979668
Annu Rev Virol. 2016 Sep 29;3(1):387-409
27482898
Nature. 2015 Jun 11;522(7555):236-9
26040713
Cell. 2012 May 11;149(4):832-46
22579286
Cell Rep. 2015 Dec 29;13(12 ):2645-52
26711332
Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14276-81
21821792
J Virol. 2015 Sep;89(17):8982-98
26085152
Mol Biol Cell. 2010 Dec;21(23):4197-211
20926687
PLoS Pathog. 2012 Sep;8(9):e1002904
22969426
Adv Virus Res. 2016;94:81-140
26997591
J Gen Virol. 2007 Jun;88(Pt 6):1810-20
17485543
Cell. 2014 Oct 9;159(2):388-401
25303532
J Virol. 2011 Nov;85(22):11675-84
21880751
J Virol. 2011 Nov;85(22):11664-74
21880748
PLoS Pathog. 2015 Jun 17;11(6):e1004957
26083367
Science. 2016 Apr 15;352(6283):359-62
27013426