Asymmetric Synthesis of Isoquinoline Alkaloids: 2004-2015.
In the past decade, the asymmetric synthesis of chiral nonracemic isoquinoline alkaloids, a family of natural products showing a wide range of structural diversity and biological and pharmaceutical activity, has been based either on continuation or improvement of known traditional methods or on new, recently developed, strategies. Both diastereoselective and enantioselective catalytic methods have been applied. This review describes the stereochemically modified traditional syntheses (the Pictet-Spengler, the Bischler-Napieralski, and the Pomeranz-Fritsch-Bobbitt) along with strategies based on closing of the nitrogen-containing ring B of the isoquinoline core by the formation of bonds between C1-N2, N2-C3, C1-N2/N2-C3, and C1-N2/C4-C4aatoms. Methods involving introduction of substituents at the C1 carbon of isoquinoline core along with syntheses applying various biocatalytic techniques have also been reviewed.
Faculty of Chemistry, Adam Mickiewicz University , Umultowska 89b, 61-614 Poznań, Poland.
Maria
M
Chrzanowska
Faculty of Chemistry, Adam Mickiewicz University , Umultowska 89b, 61-614 Poznań, Poland.
Agnieszka
A
Grajewska
Faculty of Chemistry, Adam Mickiewicz University , Umultowska 89b, 61-614 Poznań, Poland.
Maria D
MD
Rozwadowska
D000470:Alkaloids / Q000138:chemical synthesis*; D060326:Chemistry Techniques, Synthetic / Q000266:history; D003500:Cyclization; D049674:History, 21st Century; D007546:Isoquinolines / Q000138:chemical synthesis*; D010084:Oxidation-Reduction; D013237:Stereoisomerism
D000470:Alkaloids; D007546:Isoquinolines