The Effects of Syzygium samarangense, Passiflora edulis and Solanum muricatum on Alcohol-Induced Liver Injury.
Previous studies have shown that fruits have different effects on alcohol metabolism and alcohol-induced liver injury. The present work selected three fruits and aimed at studying the effects ofSyzygium samarangense,Passiflora edulisandSolanum muricatumon alcohol-induced liver injury in mice. The animals were treated daily with alcohol and fruit juices for fifteen days. Chronic treatment with alcohol increased the levels of aspartate transaminase (AST), alanine transaminase (ALT), total bilirubin (TBIL), triglyceride (TG), malondialdehyde (MDA), and decreased total protein (TP). Histopathological evaluation also showed that ethanol induced extensive fat droplets in hepatocyte cytoplasm.Syzygium samarangenseandPassiflora edulisnormalized various biochemical parameters.Solanum muricatumincreased the level of ALT and induced infiltration of inflammatory cells in the liver. These results strongly suggest that treatment withSyzygium samarangenseandPassiflora eduliscould protect liver from the injury of alcohol, whileSolanum muricatumcould aggravate the damage.
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. zhyujie3@mail2.sysu.edu.cn.
Yu-Jie
YJ
Zhang
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. zhout43@mail2.sysu.edu.cn.
Tong
T
Zhou
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. missingfeng@yeah.net.
Fang
F
Wang
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. zhouyue3@mail2.sysu.edu.cn.
Yue
Y
Zhou
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. liya28@mail2.sysu.edu.cn.
Ya
Y
Li
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. zhangjj46@mail2.sysu.edu.cn.
Jiao-Jiao
JJ
Zhang
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. zhengj37@mail2.sysu.edu.cn.
Jie
J
Zheng
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. xudp@mail2.sysu.edu.cn.
Dong-Ping
DP
Xu
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. lihuabin@mail.sysu.edu.cn.|South China Sea Bioresource Exploitation and Utilization Collaborative Innovation Center, Sun Yat-sen University, Guangzhou 510006, China. lihuabin@mail.sysu.edu.cn.
Hua-Bin
HB
Li
Passiflora edulis; Solanum muricatum; Syzygium samarangense; alcohol; liver injury
Alcohol Clin Exp Res. 2014 Jul;38(7):1982-92
24848081
Toxicol In Vitro. 2011 Jun;25(4):969-78
21414402
Pharmacol Rep. 2013;65(4):906-13
24145085
Biosci Trends. 2012 Apr;6(2):89-97
22621991
Drug Alcohol Depend. 2014 Oct 1;143:112-9
25107314
Biochem Pharmacol. 1981 Jul 1;30(13):1745-51
7023487
Food Chem Toxicol. 2012 Feb;50(2):363-72
22019691
Food Chem Toxicol. 2012 Jul;50(7):2335-41
22525864
Arch Pharm Res. 2014 Dec;37(12):1624-33
24668153
Annu Rev Pharmacol Toxicol. 2004;44:27-42
14744237
Biochem Biophys Res Commun. 1972 Dec 4;49(5):1187-93
4405124
Food Funct. 2014 May;5(5):900-8
24603671
Hepatology. 1999 Jun;29(6):1680-9
10347108
Indian J Clin Biochem. 2009 Jul;24(3):301-6
23105853
Ann Oncol. 2013 Mar;24(3):807-16
23104725
Molecules. 2016 Jan 07;21(1):64
26751438
J Med Food. 2009 Apr;12 (2):327-33
19459733
Pharmacogn Mag. 2015 Oct-Dec;11(44):707-15
26600714
J Biol Chem. 1975 Sep 25;250(18):7397-404
240827
Afr J Tradit Complement Altern Med. 2007 Oct 27;5(1):39-45
20162053
Biomed Res Int. 2013;2013:693613
23484140
Int J Environ Res Public Health. 2016 Apr 01;13(4):399
27043608
Food Chem Toxicol. 2012 Jul;50(7):2508-14
22554647
J Agric Food Chem. 2014 Mar 19;62(11):2364-73
24564852
Subcell Biochem. 2013;67:1-104
23400917
Int J Environ Res Public Health. 2016 May 24;13(6):null
27231920
J Vet Sci. 2014;15(1):141-8
24378582
Clin Chim Acta. 2005 May;355(1-2):61-5
15820479
Nat Protoc. 2013 Mar;8(3):627-37
23449255
J Agric Food Chem. 2010 Mar 24;58(6):3859-66
20192205
Food Chem Toxicol. 2009 Aug;47(8):1945-9
19457445
Pathol Biol (Paris). 2001 Nov;49(9):676-82
11762128
Alcohol Clin Exp Res. 1986;10(6 Suppl):20S-32S
3544926
Nutrients. 2014 Dec 22;6(12):6020-47
25533011
J Physiol Biochem. 2013 Jun;69(2):227-37
22893526
Physiol Rev. 1997 Apr;77(2):517-44
9114822
Food Funct. 2012 Jun;3(6):628-34
22648047