The battlefield in the war against attaching-and-effacing bacterial pathogens: Monocytes, macrophages and dendritic cells in action.
The recent adoption of a unified nomenclature for the mononuclear phagocyte system has already led to the generation of novel strategies for specifically depleting a single subset of phagocytes in the presence of intact lymphoid structures. Herein, we provide a detailed description of how the various types of tissue phagocyte orchestrate the host's defense against enteric bacterial infections. From a bench-to-bedside perspective, we expect that this paradigm will accelerate the development of novel adjuvants and vaccines in human and veterinary microbiology.
Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000 Lille, France. Electronic address: lionel.poulin@cnrs.fr.
Lionel F
LF
Poulin
Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000 Lille, France. Electronic address: mathias.chamaillard@inserm.fr.
Mathias
M
Chamaillard
D056704:Adaptive Immunity; D000818:Animals; D001422:Bacterial Adhesion / Q000502:physiology*; D003713:Dendritic Cells / Q000502:physiology*; D006801:Humans; D008264:Macrophages / Q000502:physiology*; D009000:Monocytes / Q000502:physiology*; D012157:Mononuclear Phagocyte System / Q000502:physiology*
Dendritic cell; Enteric bacterial infection; Macrophage; Monocyte