Reduced Appendicular Lean Body Mass, Muscle Strength, and Size of Type II Muscle Fibers in Patients with Spondyloarthritis versus Healthy Controls: A Cross-Sectional Study.
Introduction. The purpose of this study was to investigate body composition, muscle function, and muscle morphology in patients with spondyloarthritis (SpA).Methods. Ten male SpA patients (mean ± SD age 39 ± 4.1 years) were compared with ten healthy controls matched for sex, age, body mass index, and self-reported level of physical exercise. Body composition was measured by dual energy X-ray absorptiometry. Musculus quadriceps femoris (QF) strength was assessed by maximal isometric contractions prior to test of muscular endurance. Magnetic resonance imaging of QF was used to measure muscle size and calculate specific muscle strength. Percutaneous needle biopsy samples were taken fromm. vastus lateralis.Results. SpA patients presented with significantly lower appendicular lean body mass (LBM) (p= 0.02), but there was no difference in bone mineral density, fat mass, or total LBM. Absolute QF strength was significantly lower in SpA patients (p= 0.03) with a parallel trend for specific strength (p= 0.08). Biopsy samples from the SpA patients revealed significantly smaller cross-sectional area (CSA) of type II muscle fibers (p= 0.04), but no difference in CSA type I fibers.Conclusions. Results indicate that the presence of SpA disease is associated with reduced appendicular LBM, muscle strength, and type II fiber CSA.
Diakonhjemmet Hospital, National Unit for Rehabilitation in Rheumatology, Department of Rheumatology, Postboks 23 Vinderen, 0319 Oslo, Norway; Norwegian School of Sport Sciences, Sognsveien 220, 0863 Oslo, Norway.
Kristine
0000-0001-6664-7542
K
Røren Nordén
Diakonhjemmet Hospital, National Advisory Unit on Rehabilitation in Rheumatology, Postboks 23 Vinderen, 0319 Oslo, Norway.
Hanne
0000-0001-7097-2962
H
Dagfinrud
Norwegian School of Sport Sciences, Sognsveien 220, 0863 Oslo, Norway.
Amund
0000-0003-0312-8600
A
Løvstad
Norwegian School of Sport Sciences, Sognsveien 220, 0863 Oslo, Norway.
Truls
0000-0002-2567-3004
T
Raastad
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