Antioxidant and Vasodilator Activity ofUgni molinaeTurcz. (Murtilla) and Its Modulatory Mechanism in Hypotensive Response.
Hypertension is a systemic condition with high morbidity and mortality rates worldwide, which poses an increased risk for cardiovascular diseases. In this study, we demonstrated the antioxidant and vasodilator activity ofUgni molinaeTurcz. (Murtilla) fruit, a berry native to Chile and proposed models to explain its modulatory mechanism in hypotensive response. Murtilla fruits were cultivated in a germplasm bank and submitted to chemical and biological analyses. The phenolic compounds gallic acid, Catechin, Quercetin-3-β-D-glucoside, Myricetin, Quercetin, and Kaempferol were identified. Murtilla extract did not generate toxic effects on human endothelial cells and had significant antioxidant activity against ROS production, lipid peroxidation, and superoxide anion production. Furthermore, it showed dose-dependent vasodilator activity in aortic rings in the presence of endothelium, whose hypotensive mechanism is partially mediated by nitric oxide synthase/guanylate cyclase and large-conductance calcium-dependent potassium channels. Murtilla fruits might potentially have beneficial effects on the management of cardiovascular diseases.
Center for Neurosciences and Peptides Biology, CEGIN-BIOREN-UFRO, Department of Preclinical Sciences, Faculty of Medicine, University La Frontera, Francisco Salazar 01145, 4811230 Temuco, Chile.
Ignacio
I
Jofré
Center for Neurosciences and Peptides Biology, CEGIN-BIOREN-UFRO, Department of Preclinical Sciences, Faculty of Medicine, University La Frontera, Francisco Salazar 01145, 4811230 Temuco, Chile.
Cesar
C
Pezoa
Center for Neurosciences and Peptides Biology, CEGIN-BIOREN-UFRO, Department of Preclinical Sciences, Faculty of Medicine, University La Frontera, Francisco Salazar 01145, 4811230 Temuco, Chile.
Magdalena
0000-0003-2079-7910
M
Cuevas
Department of Chemical Engineering, University La Frontera, Francisco Salazar 01145, 4811230 Temuco, Chile.
Erick
E
Scheuermann
Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, 13414-903 Piracicaba, SP, Brazil.
Irlan Almeida
0000-0002-1079-6941
IA
Freires
Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, 13414-903 Piracicaba, SP, Brazil.
Pedro Luiz
PL
Rosalen
Department of Agri-Food industry, "Luiz de Queiroz" College of Agriculture, University of São Paulo, 13418-900 Piracicaba, SP, Brazil.
Severino Matias
0000-0002-6637-7973
SM
de Alencar
Center for Neurosciences and Peptides Biology, CEGIN-BIOREN-UFRO, Department of Preclinical Sciences, Faculty of Medicine, University La Frontera, Francisco Salazar 01145, 4811230 Temuco, Chile.
Fernando
F
Romero
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