Mechanisms of ciliogenesis suppression in dividing cells.
The primary cilium is a non-motile and microtubule-enriched protrusion ensheathed by plasma membrane. Primary cilia function as mechano/chemosensors and signaling hubs and their disorders predispose to a wide spectrum of human diseases. Most types of cells assemble their primary cilia in response to cellular quiescence, whereas they start to retract the primary cilia upon cell-cycle reentry. The retardation of ciliary resorption process has been shown to delay cell-cycle progression to the S or M phase after cell-cycle reentry. Apart from this conventional concept of ciliary disassembly linked to cell-cycle reentry, recent studies have led to a novel concept, suggesting that cells can suppress primary cilia assembly during cell proliferation. Accumulating evidence has also demonstrated the importance of Aurora-A (a protein originally identified as one of mitotic kinases) not only in ciliary resorption after cell-cycle reentry but also in the suppression of ciliogenesis in proliferating cells, whereas Aurora-A activators are clearly distinct in both phenomena. Here, we summarize the current knowledge of how cycling cells suppress ciliogenesis and compare it with mechanisms underlying ciliary resorption after cell-cycle reentry. We also discuss a reciprocal relationship between primary cilia and cell proliferation.
Division of Biochemistry, Aichi Cancer Center Research Institute, Nagoya, 464-8681, Japan. hgoto@aichi-cc.jp.|Department of Cellular Oncology, Graduate School of Medicine, Nagoya University, Nagoya, 466-8550, Japan. hgoto@aichi-cc.jp.
Hidemasa
H
Goto
Division of Biochemistry, Aichi Cancer Center Research Institute, Nagoya, 464-8681, Japan.
Hironori
H
Inaba
Department of Physiology, Mie University School of Medicine, Tsu, Mie, Japan. minagaki@doc.medic.mie-u.ac.jp.
Masaki
M
Inagaki
D000818:Animals; D002453:Cell Cycle; D002455:Cell Division; D049109:Cell Proliferation; D002923:Cilia / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D038081:Organogenesis
Aurora-A; Cancer; Cell cycle; Ciliopathy; Primary cilia
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