Long non-coding RNAs: potential new biomarkers for predicting tumor invasion and metastasis.
Long non-coding RNAs (lncRNAs) play important roles in malignant neoplasia. Indeed, many hallmarks of cancer define that the malignant phenotype of tumor cells are controlled by lncRNAs. Despite a growing number of studies highlighting their importance in cancer, there has been no systematic review of metastasis-associated lncRNAs in various cancer types. Accordingly, we focus on the key metastasis-related lncRNAs and outline their expression status in cancer tissues by reviewing the previous stuides, in order to summarize the nowadays research achivements for lncRNAs related to cancer metastasis. Medline, EMBASE, as well as PubMed databases were applied to study lncRNAs which were tightly associated with tumor invasion and metastasis. Up to now, a substantial number of lncRNAs have been found to have important biological functions. In this review, according to their various features in cancer, lncRNAs were roughly divided into three categories: promoting tumor invasion and metastasis, negative regulation of tumor metastasis and with dual regulatory roles. The present studies may establish the foundation for both further research on the mechanisms of cancer progression and future lncRNA-based clinical applications.
Department of Thoracic Surgery, Tianjin Union Medical Center, 190 Jieyuan Road, Hongqiao District, Tianjin, 300121, People's Republic of China.
Chunyang
C
Jiang
Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute; Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, 154 An Shan Road, Heping District, Tianjin, 300052, People's Republic of China.
Xin
X
Li
Department of Thoracic Surgery, Tianjin Union Medical Center, 190 Jieyuan Road, Hongqiao District, Tianjin, 300121, People's Republic of China.
Hui
H
Zhao
Department of pharmacology, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, 830011, People's Republic of China. lhbrose2010@126.com.
Huibin
H
Liu
Biomarker; Cancer; Invasion; Long non-coding RNA; Metastasis
Int J Mol Sci. 2014 Mar 06;15(3):4060-76
24663081
Cell Death Dis. 2014 Jun 12;5:e1287
24922071
Cancer Sci. 2013 Apr;104(4):458-64
23281836
J Exp Clin Cancer Res. 2015 Feb 19;34:18
25884472
Biomed Pharmacother. 2015 May;72:109-12
26054683
Int J Oncol. 2015 Feb;46(2):521-30
25405331
Oncol Rep. 2014 Jul;32(1):395-402
24840737
Oncogene. 2015 Jun 4;34(23):3076-84
25088204
Melanoma Res. 2014 Aug;24(4):335-41
24892958
Hum Mol Genet. 2015 Feb 1;24(3):841-52
25292198
Int J Clin Exp Pathol. 2014 Oct 15;7(11):7938-44
25550835
Eur Rev Med Pharmacol Sci. 2014 Jul;18(13):1930-6
25010625
Oncol Lett. 2014 Aug;8(2):869-875
25013510
J Gastroenterol Hepatol. 2015 Sep;30(9):1367-75
25866896
Cancer Res. 2011 Jun 1;71(11):3852-62
21558391
Biochim Biophys Acta. 2013 Oct;1832(10):1528-37
23688781
Cancer Gene Ther. 2015 Apr;22(3):138-44
25591808
FEBS J. 2014 Aug;281(16):3766-75
24988946
Int J Oncol. 2012 Jul;41(1):276-84
22576688
Genes Dev. 2009 Jul 1;23(13):1494-504
19571179
Cancer Gene Ther. 2015 Feb 27;:null
25721209
Mol Med Rep. 2015 Apr;11(4):3155-9
25516208
Neoplasia. 2014 Dec;16(12):1121-7
25499224
Mol Cancer Res. 2015 May;13(5):828-38
25700553
Biochem Biophys Res Commun. 2014 Apr 4;446(2):448-53
24631686
Anticancer Res. 2015 Mar;35(3):1385-8
25750289
Asian Pac J Cancer Prev. 2013;14(2):1077-82
23621190
Carcinogenesis. 2014 Dec;35(12):2731-9
25280565
Int J Clin Exp Pathol. 2014 May 15;7(6):2758-67
25031695
Nature. 2009 Mar 12;458(7235):223-7
19182780
Int J Oncol. 2011 Jul;39(1):169-75
21503572
J Exp Clin Cancer Res. 2014 Sep 10;33:72
25200485
FEBS J. 2012 Sep;279(17):3159-65
22776265
Br J Cancer. 2013 Oct 15;109(8):2266-78
24022190
Biochem Biophys Res Commun. 2014 Aug 22;451(2):171-8
25063030
RNA Biol. 2012 Jun;9(6):703-19
22664915
Tumour Biol. 2015 Mar;36(3):1643-51
25366138
Cancer Res. 2014 Dec 1;74(23):6890-902
25277524
Mol Cancer. 2011 Apr 13;10:38
21489289
Tumour Biol. 2015 Apr;36(4):2947-55
25480417
J Huazhong Univ Sci Technolog Med Sci. 2014 Jun;34(3):363-9
24939300
Genome Res. 2013 Sep;23 (9):1446-61
23796952
Exp Cell Res. 2002 May 1;275(2):215-29
11969291
Int J Gynecol Cancer. 2014 May;24(4):635-42
24758900
Tumour Biol. 2015 May;36(5):3611-9
25547435
Urology. 2014 Sep;84(3):730.e1-7
25168566
Cancer Lett. 2015 Apr 1;359(1):75-86
25578780
Oncotarget. 2013 Oct;4(10):1748-62
24077681
Gynecol Oncol. 2014 Jul;134(1):121-8
24662839
J Int Med Res. 2011;39(6):2119-28
22289527
Oncogene. 2016 Jan 7;35(1):12-21
25772239
Carcinogenesis. 2013 Jun;34(6):1343-51
23430956
Cancer Sci. 2013 Dec;104(12):1675-82
24118380
J Thorac Oncol. 2011 Dec;6(12):1984-92
22088988
Tumour Biol. 2014 Aug;35(8):7743-54
24810925
Med Oncol. 2014 May;31(5):914
24671855
BMC Cancer. 2013 Oct 08;13:464
24103700
Gut. 2014 Jun;63(6):881-90
24000294
Nat Rev Genet. 2011 Nov 18;12(12):861-74
22094949
Biochim Biophys Acta. 2015 Jan;1852(1):166-74
25446987
Genome Res. 2012 Jun;22(6):1006-14
22581800
Tumour Biol. 2015 Sep;36(9):7205-11
25894373
J Exp Clin Cancer Res. 2015 Jan 22;34:7
25613496
Br J Cancer. 2014 Aug 12;111(4):736-48
25025966
Biochem Biophys Res Commun. 2015 Feb 20;457(4):500-6
25592968
PLoS One. 2013 Nov 11;8(11):e78700
24244343
Br J Cancer. 2014 Nov 25;111(11):2131-41
25314054
Tumour Biol. 2014 Aug;35(8):7935-44
24833086
Cell Signal. 2015 Feb;27(2):275-82
25446261
Tumour Biol. 2014 Nov;35(11):11541-9
25129441
RNA. 2015 Jun;21(6):1122-34
25904139
PLoS One. 2010 Apr 23;5(4):e10316
20428234
Int J Clin Exp Pathol. 2014 May 15;7(6):3065-72
25031725
Biomaterials. 2015 Mar;44:71-81
25617127
Oncotarget. 2014 Apr 30;5(8):2318-29
24810858
Cancer Lett. 2013 Jun 10;333(2):213-21
23354591
Mol Endocrinol. 2015 Feb;29(2):224-37
25565142
J Cancer Res Clin Oncol. 2013 Mar;139(3):437-45
23143645
Biomed Pharmacother. 2014 May;68(4):401-7
24721325
Int J Oncol. 2015 ;46(6):2586-94
25901533
Int J Clin Exp Pathol. 2014 May 15;7(6):2838-49
25031703
PLoS One. 2014 Jul 09;9(7):e100340
25007342
Oncotarget. 2014 Apr 15;5(7):1793-804
24742640
Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Jan;117(1):89-95
24332332
Mol Carcinog. 2013 Nov;52(11):908-15
24151120
Am J Transl Res. 2012;4(2):127-50
22611467
Clin Cancer Res. 2014 Mar 15;20(6):1531-41
24449823
Int J Oncol. 2014 Jun;44(6):2041-9
24691949
Hum Mol Genet. 2010 Oct 15;19(R2):R162-8
20798109
PLoS One. 2013 May 23;8(5):e63516
23717443
Int J Oncol. 2013 Aug;43(2):566-74
23722988
Mol Cancer. 2014 Apr 28;13:92
24775712
J Biol Chem. 2015 Feb 13;290(7):3925-35
25538231
Oncol Rep. 2014 Dec;32(6):2485-92
25269958
Toxicol Lett. 2014 Sep 17;229(3):430-9
25050996
J Urol. 2013 Dec;190(6):2278-87
23845456
Tumour Biol. 2014 Sep;35(9):9163-9
24920070
Mol Cancer. 2014 Jan 06;13:3
24393131
Oncogene. 2013 Mar 28;32(13):1616-25
22614017
Pathology. 2014 Aug;46(5):396-401
24977734
RNA Biol. 2010 Sep-Oct;7(5):582-5
20930520
Mol Cancer. 2014 Mar 21;13:68
24655544
Mol Cell Biochem. 2014 Sep;394(1-2):177-86
24889262
Cell. 2014 Nov 20;159(5):1110-25
25416949
Gene. 2015 Apr 10;560(1):1-8
25659765
Oncotarget. 2014 Feb 15;5(3):764-74
24519926
Biochem Biophys Res Commun. 2014 Mar 7;445(2):388-93
24525122
Cancer Res. 2013 Feb 1;73(3):1180-9
23243023
Biochem Biophys Res Commun. 2013 Jun 28;436(2):319-24
23743197
Biomed Pharmacother. 2015 Feb;69:90-5
25661343
Biol Cell. 2012 Jan;104(1):3-12
22188537
Cancer Res. 2011 Jan 1;71(1):3-7
21199792
Gastroenterology. 2013 May;144(5):956-966.e4
23333711
PLoS One. 2011;6(10):e25915
21991387
Trends Cell Biol. 2011 Jun;21(6):354-61
21550244
J Hematol Oncol. 2014 Aug 29;7:63
25167886
Mol Cancer Res. 2014 Aug;12(8):1081-7
25030374
J Biol Chem. 2015 Mar 13;290(11):6857-67
25605728
Nature. 2010 Apr 15;464(7291):1071-6
20393566
PLoS One. 2013 Aug 01;8(8):e70372
23936419
J Steroid Biochem Mol Biol. 2014 May;141:60-70
24380700
Nat Rev Genet. 2009 Mar;10(3):155-9
19188922
Tumour Biol. 2014 Jul;35(7):6901-12
24737584
Mol Biosyst. 2012 Sep;8(9):2289-94
22722759