Incidence and Risk Factors of Refeeding Syndrome in Head and Neck Cancer Patients-An Observational Study.
This study aimed to determine the incidence rates of refeeding phenomena (defined as a decline in p-phosphate) and refeeding syndrome (RFS; defined as development of clinical symptoms in addition to a decline in p-phosphate) in head and neck cancer patients, and to identify risk factors. Fifty-four head and neck cancer patients referred for surgery were included. Forty-six potential risk factors were registered at the baseline, and p-phosphate was measured at Days 2, 4, and 7. Eleven patients (20%) developed RFS, and twenty-eight (52%) developed refeeding phenomena. At baseline, these patients presented a higher prevalence of head and neck pain, eating difficulties, higher p-phosphate levels, lower p-transferrin levels, and, in men, lower b-hemoglobin levels. Patients who developed symptoms had a decline in p-phosphate ≥0.22 mmol/l. At baseline, these patients had higher p-phosphate levels, higher alcohol consumption, and lower p-transferrin and p-sodium levels, as well as a higher prevalence of eating difficulties, low handgrip strength (HGS), and a history of radiation therapy. The risk factors most strongly associated with the development of refeeding phenomena and RFS were pain, eating difficulties, low HGS, high alcohol intake, and previous radiation therapy.
a Department of Nutrition, Exercise and Sports , University of Copenhagen , Copenhagen , Denmark.
Stine Ostenfeldt
SO
Rasmussen
a Department of Nutrition, Exercise and Sports , University of Copenhagen , Copenhagen , Denmark.
Marianne Boll
MB
Kristensen
b Department of Otorhinolaryngology and Audiology 2071 , Rigshospitalet , Copenhagen , Denmark.
Irene
I
Wessel
a Department of Nutrition, Exercise and Sports , University of Copenhagen , Copenhagen , Denmark.|c Nutrition Unit 5711 , Rigshospitalet , Copenhagen , Denmark.
Jens Rikardt
JR
Andersen
D000368:Aged; D005260:Female; D018737:Hand Strength; D006258:Head and Neck Neoplasms / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000097:blood; D055677:Refeeding Syndrome / Q000453:epidemiology* / Q000209:etiology*; D012307:Risk Factors
D010710:Phosphates