Bone status assessed by quantitative ultrasound in children with inflammatory bowel disease: a comparison with DXA.
BACKGROUND
To determine the bone status in children with inflammatory bowel diseases (IBD) using quantitative ultrasound (QUS) measurement at hand phalanges and compare the obtained results with dual-energy X-ray absorptiometry (DXA).


METHODS
Fifty-one children with IBD underwent DXA and QUS measurements at hand phalanges in the year 2013. The control group for the QUS consisted of 460 children. Reference data for DXA comes from Hologic Explorer.


RESULTS
QUS measurements did not differ significantly between IBD patients and healthy controls. There was no difference between UC and CD subjects. DXA measurements in patients with IBD were lower than in the healthy population. Tanner stage and nutritional status correlated with bone status contrary to steroids therapy.


CONCLUSIONS
Low bone mineral density often complicates IBD in children. QUS is not an appropriate method for the assessment of bone status in children. Nutritional status seems to have a greater impact on bone status than corticosteroids therapy.
a Department of Pediatrics, School of Medicine with the Division of Dentistry in Zabrze , Medical University of Silesia , Katowice , Poland.
Katarzyna
K
Bąk-Drabik
a Department of Pediatrics, School of Medicine with the Division of Dentistry in Zabrze , Medical University of Silesia , Katowice , Poland.
Piotr
P
Adamczyk
b Department of Pediatrics , Public Clinical Hospital No. 1 , Zabrze , Poland.
Agata
A
Chobot
a Department of Pediatrics, School of Medicine with the Division of Dentistry in Zabrze , Medical University of Silesia , Katowice , Poland.
Jarosław
J
Kwiecień
c Department of Internal Medicine, Diabetology and Nephrology, Metabolic Bone Diseases Unit, School of Medicine with the Division of Dentistry in Zabrze , Medical University of Silesia , Katowice , Poland.
Wojciech
W
Pluskiewicz
D015502:Absorptiometry, Photon; D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000367:Age Factors; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000000981:diagnostic imaging* / Q000209:etiology; D016022:Case-Control Studies; D002648:Child; D003093:Colitis, Ulcerative / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D003424:Crohn Disease / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D050278:Finger Phalanges / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D015596:Nutrition Assessment; D009752:Nutritional Status; D011237:Predictive Value of Tests; D012307:Risk Factors; D014463:Ultrasonography
D000305:Adrenal Cortex Hormones
Inflammatory bowel diseases; bone mineral status; quantitative ultrasound