Bioactivity and biocompatibility of two fluoride containing bioactive glasses for dental applications.
Bioactive glasses (BAG) form, in contrast to formerly used implant materials, a stable bond with tissues, especially bone, when implanted. Nowadays BAGs are often mixed with a cement/composite that hardens in situ to broaden its applications in dentistry or orthopedics. The bioactivity and biocompatibility of possible BAG candidates for BAG-cement/composite development were evaluated.



Two fluoride containing BAGs were tested: a Na+-containing (45S5F), based on the first commercial BAG, and a Na+-free BAG (CF9), with a higher Ca2+and PO43-content. BAGs were tested on their bioactivity upon immersion in SBF for 7days by evaluating the surface changes by FT-IR, SEM, EDS and PO43-and Ca2+uptake and/or release from SBF. Moreover, the biocompatibility of the BAGs was investigated with a direct contact cell viability study with HFF cells and a cell adhesion study with MG-63 cells.



The Na+-free BAG, CF9, showed the highest potential to bioactivate cements because of its high Ca2+-release and apatite (Ap) formation, as evidenced by SEM pictures and corresponding EDX patterns. FT-IR confirmed the formation of an Ap layer. Moreover CF9 had a higher biocompatibility than 45S5F.



For the bioactivation of GICs/composites in order to enhance bonding and remineralization of surrounding tissues, fluoride containing BAG may have advantages over other BAGs as a more stable fluorapatite can be formed. CF9 may be an excellent candidate therefore.
Biomaterials Group, Department of Basic Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, De Pintelaan 185, Bdg B, 4th Floor, 9000 Ghent, Belgium. Electronic address: tamara.decaluwe@ugent.be.
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De Caluwé
Biomaterials Group, Department of Basic Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, De Pintelaan 185, Bdg B, 4th Floor, 9000 Ghent, Belgium.
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Vercruysse
Tissue Engineering Group, Ghent University, De Pintelaan 185, 6B3, 9000 Ghent, Belgium.
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HA
Declercq
Center for Microsystems Technology (CMST), IMEC and Ghent University, Technologiepark 15, B-9052 Ghent, Belgium.
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Schaubroeck
Biomaterials Group, Department of Basic Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, De Pintelaan 185, Bdg B, 4th Floor, 9000 Ghent, Belgium.
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Verbeeck
Department of Paediatric Dentistry and Special Care Dentistry, Faculty of Medicine and Health Sciences, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium.
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Martens
D001843:Bone Cements; D015921:Dental Implants; D005347:Fibroblasts; D005459:Fluorides; D005899:Glass Ionomer Cements; D006801:Humans; D008422:Materials Testing; D017550:Spectroscopy, Fourier Transform Infrared
D001843:Bone Cements; D015921:Dental Implants; D005899:Glass Ionomer Cements; D005459:Fluorides
Apatite; Bioactive glass; Bioactivity; Biocompatibility; Fluoride