Impact of maternal nutrition in pregnancy and lactation on offspring gut microbial composition and function.
Evidence supporting the Developmental Origins of Health and Disease Hypothesis indicates that maternal nutrition in pregnancy has a significant impact on offspring disease risk later in life, likely by modulating developmental processes in utero. Gut microbiota have recently been explored as a potential mediating factor, as dietary components strongly influence microbiota abundance, function and its impact on host physiology. A growing body of evidence has additionally indicated that the intrauterine environment is not sterile as once presumed, indicating that maternal-fetal transmission of microbiota may occur during pregnancy. In this article, we will review the body of literature that supports this emerging hypothesis, as well as highlight the work in relevant animal models demonstrating associations with maternal gestational nutrition and the offspring gut microbiome that may influence offspring physiology and susceptibility to disease.
a Department of Obstetrics and Gynecology , Baylor College of Medicine , Houston , TX.|b Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine , Houston , TX.|c Medical Scientist Training Program, Baylor College of Medicine , Houston , TX.
Derrick M
DM
Chu
a Department of Obstetrics and Gynecology , Baylor College of Medicine , Houston , TX.|c Medical Scientist Training Program, Baylor College of Medicine , Houston , TX.|d Department of Molecular & Human Genetics , Baylor College of Medicine , Houston , TX.
Kristen M
KM
Meyer
a Department of Obstetrics and Gynecology , Baylor College of Medicine , Houston , TX.
Amanda L
AL
Prince
a Department of Obstetrics and Gynecology , Baylor College of Medicine , Houston , TX.|b Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine , Houston , TX.|c Medical Scientist Training Program, Baylor College of Medicine , Houston , TX.|d Department of Molecular & Human Genetics , Baylor College of Medicine , Houston , TX.|e Department of Molecular & Cell Biology , Baylor College of Medicine , Houston , TX.|f Department of Molecular Physiology & Biophysics , Baylor College of Medicine , Houston , TX.
Kjersti M
KM
Aagaard
D000818:Animals; D005260:Female; D047109:Fetal Development; D000069196:Gastrointestinal Microbiome; D006801:Humans; D007774:Lactation; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D008431:Maternal-Fetal Exchange; D011247:Pregnancy
DOHaD; gut microbiome; gut microbiota; gut-brain axis; high-fat diet; immune development; maternal diet; obesity; pregnancy
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