Synthesis and Evaluation of Paclitaxel-Loaded Gold Nanoparticles for Tumor-Targeted Drug Delivery.
The synthesis of a series of thiolated paclitaxel analogs is described as part of a novel nanomedicine program aimed at developing formulations of paclitaxel that will bind to gold nanoparticles for tumor targeted drug delivery. Preliminary evaluation of the new nanomedicine composed of 27 nm gold nanoparticles, tumor necrosis factor alpha (TNFα), thiolated polyethylene glycol (PEG-thiol), and one of several thiolated paclitaxel analogs is presented.
CytImmune Sciences Inc. , 15010 Broschart Road, Rockville, Maryland 20850, United States.
Giulio F
GF
Paciotti
Department of Chemistry and the Virginia Tech Center for Drug Discovery, Virginia Tech , Blacksburg, Virginia 24061, United States.
Jielu
J
Zhao
Department of Chemistry and the Virginia Tech Center for Drug Discovery, Virginia Tech , Blacksburg, Virginia 24061, United States.
Shugeng
S
Cao
Department of Chemistry and the Virginia Tech Center for Drug Discovery, Virginia Tech , Blacksburg, Virginia 24061, United States.
Peggy J
PJ
Brodie
CytImmune Sciences Inc. , 15010 Broschart Road, Rockville, Maryland 20850, United States.
Lawrence
L
Tamarkin
CytImmune Sciences Inc. , 15010 Broschart Road, Rockville, Maryland 20850, United States.
Marja
M
Huhta
CytImmune Sciences Inc. , 15010 Broschart Road, Rockville, Maryland 20850, United States.
Lonnie D
LD
Myer
CytImmune Sciences Inc. , 15010 Broschart Road, Rockville, Maryland 20850, United States.
Jay
J
Friedman
Department of Chemistry and the Virginia Tech Center for Drug Discovery, Virginia Tech , Blacksburg, Virginia 24061, United States.
David G I
DG
Kingston
D000818:Animals; D002021:Buffers; D045744:Cell Line, Tumor; D060326:Chemistry Techniques, Synthetic; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry*; D065546:Drug Liberation; D006046:Gold / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D008958:Models, Molecular; D017239:Paclitaxel / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000737:chemistry; D011487:Protein Conformation; D014409:Tumor Necrosis Factor-alpha / Q000737:chemistry
D002021:Buffers; D004337:Drug Carriers; D014409:Tumor Necrosis Factor-alpha; D011092:Polyethylene Glycols; D006046:Gold; D017239:Paclitaxel
Br J Cancer. 1996 Aug;74(4):533-6
8761366
J Nat Prod. 2004 Feb;67(2):152-9
14987051
Angew Chem Int Ed Engl. 2014 Apr 7;53(15):3796-827
24677743
Biochem Biophys Res Commun. 1984 Oct 30;124(2):329-36
6548627
Mol Pharm. 2010 Dec 6;7(6):2216-23
20863081
Drug Discov Today. 2014 Jul;19(7):869-81
24239727
Oncogene. 2003 Oct 20;22(47):7280-95
14576838
Cancer Chemother Pharmacol. 2015 Apr;75(4):659-70
25596818
Methods Mol Biol. 2010;624:375-84
20217609
Chem Soc Rev. 2012 Apr 7;41(7):2740-79
22109657
Chem Biol Interact. 1998 Apr 24;111-112:1-14
9679538
Drug Des Devel Ther. 2012;6:371-84
23251087
Mol Pharm. 2013 May 6;10(5):1683-94
23544801
Adv Drug Deliv Rev. 2012 Feb;64(2):200-16
21925556
ChemMedChem. 2012 Jun;7(6):952-72
22517723
J Am Chem Soc. 2009 Jan 14;131(1):66-8
19072111
Cancer Res. 1985 May;45(5):2110-5
3986765
J Am Chem Soc. 2007 Sep 19;129(37):11653-61
17718495
Br J Cancer. 2000 Mar;82(5):1000-3
10737379
Int J Cancer. 2007 Jun 1;120(11):2474-80
17330231
Cancer Res. 2002 Jan 1;62(1):307-12
11782393
Int J Radiat Oncol Biol Phys. 2015 Nov 1;93(3):588-96
26461001
J Biomater Sci Polym Ed. 2008;19(3):311-24
18325233
Bioconjug Chem. 2013 Mar 20;24(3):376-86
23360450
Bioconjug Chem. 1996 May-Jun;7(3):380-4
8816963
Bioconjug Chem. 2010 May 19;21(5):797-802
20397686
Clin Cancer Res. 2010 Dec 15;16(24):6139-49
20876255
Cancer Res. 2013 Mar 1;73(5):1524-35
23288510
J Nat Prod. 1988 Mar-Apr;51(2):298-306
2898009
Oncologist. 2006 Jan;11(1):83-4
16401717
Expert Opin Pharmacother. 2008 Oct;9(15):2603-16
18803448
J Clin Oncol. 1998 Apr;16(4):1479-89
9552055
Adv Drug Deliv Rev. 2008 Aug 17;60(11):1307-15
18555555
Clin Breast Cancer. 2014 Aug;14(4):221-7
24806278
Eur J Cancer. 1995 Jun;31A(6):1009-16
7646901
J Med Chem. 1989 Apr;32(4):788-92
2564894
Biomaterials. 2012 Jan;33(3):856-66
22036101
Angew Chem Int Ed Engl. 2014 Nov 10;53(46):12320-64
25294565
Bioorg Med Chem. 2011 Dec 15;19(24):7664-78
22071526
Nature. 1979 Feb 22;277(5698):665-7
423966
Bioorg Med Chem Lett. 2014 Dec 1;24(23):5357-63
25455482
J Am Chem Soc. 2005 Sep 14;127(36):12508-9
16144396
Clin Chim Acta. 1998 Jul 28;275(2):175-84
9721075
ACS Cent Sci. 2016 Jul 27;2(7):434-7
27504489
Int J Hyperthermia. 2007 Sep;23(6):501-11
17952764
Drug Deliv. 2004 May-Jun;11(3):169-83
15204636
Mini Rev Med Chem. 2012 May;12(5):434-44
22303950
Expert Opin Drug Deliv. 2013 Mar;10(3):325-40
23289542
J Control Release. 2010 Nov 20;148(1):122-7
20547192
J Nat Prod. 2007 Apr;70(4):679-81
17323994