The Relationship between Neurocircuitry Dysfunctions and Attention Deficit Hyperactivity Disorder: A Review.
The prefrontal cortex is the superlative structure of brain that needs the longest developmental and maturational duration that highlights the region of attention deficit hyperactivity disorder (ADHD) in neuroimaging studies. Prefrontal cortex functions generate enormously complex and its abundant feedback neurocircuitries with subcortical structures such as striatum and thalamus established through dual neural fibers. These microneurocircuitries are called corticostriatothalamocortical (CSTC) circuits. The CSTC circuits paly an essential role in flexible behaviors. The impaired circuits increase the risk of behavioral and psychological symptoms. ADHD is an especial developmental stage of paediatric disease. It has been reported that the CSTC circuits dysfunctions in ADHD are related to homologous symptoms. This study aimed to review the symptoms of ADHD and discuss the recent advances on the effects of the disease as well as the new progress of treatments with each circuit.
Shanghai Changning District Mental Health Center, Green Land Hospital of Bio-X Center, Shanghai Jiaotong University, Shanghai 200335, China.
Yuncheng
0000-0003-4686-8887
Y
Zhu
Shanghai Changning District Mental Health Center, Green Land Hospital of Bio-X Center, Shanghai Jiaotong University, Shanghai 200335, China.
Daoliang
0000-0001-6305-4418
D
Yang
Shanghai Changning District Mental Health Center, Green Land Hospital of Bio-X Center, Shanghai Jiaotong University, Shanghai 200335, China.
Weidong
W
Ji
Shanghai Changning District Mental Health Center, Green Land Hospital of Bio-X Center, Shanghai Jiaotong University, Shanghai 200335, China.
Tianming
T
Huang
Shanghai Changning District Mental Health Center, Green Land Hospital of Bio-X Center, Shanghai Jiaotong University, Shanghai 200335, China.
Lianxue
L
Xue
Shanghai Changning District Mental Health Center, Green Land Hospital of Bio-X Center, Shanghai Jiaotong University, Shanghai 200335, China.
Xixi
X
Jiang
Shanghai Changning District Mental Health Center, Green Land Hospital of Bio-X Center, Shanghai Jiaotong University, Shanghai 200335, China.
Liangliang
L
Chen
Shanghai Changning District Mental Health Center, Green Land Hospital of Bio-X Center, Shanghai Jiaotong University, Shanghai 200335, China.
Fang
F
Wang
Trends Neurosci. 2016 Feb;39(2):63-73
26787097
Front Syst Neurosci. 2015 Dec 17;9:171
26733823
J Atten Disord. 2016 Jan 8;:null
26748338
NeuroRehabilitation. 2016;38(2):171-8
26923356
Psychiatriki. 2015 Oct-Dec;25(4):282-94
26709994
J Abnorm Psychol. 2013 May;122(2):558-65
23713508
Brain Imaging Behav. 2016 Dec;10 (4):1080-1089
26525887
Neuropsychopharmacology. 2013 Dec;38(13):2588-97
23822950
Behav Brain Res. 2015 Oct 1;292:167-73
26068585
Neuroimage Clin. 2014 Dec 10;7:222-9
25610784
Front Integr Neurosci. 2012 Jun 14;6:29
22712007
PLoS One. 2013 Nov 04;8(11):e78738
24223847
Transl Psychiatry. 2014 Mar 18;4:e373
24643164
J Integr Neurosci. 2015 Jun;14(2):207-22
25903500
Cogn Process. 2015 Sep;16 Suppl 1:125-9
26224278
Brain Dev. 2015 Jan;37(1):76-87
24767548
PLoS One. 2016 Mar 10;11(3):e0151484
26963705
Brain Imaging Behav. 2016 Dec;10 (4):1054-1067
26518214
Hum Brain Mapp. 2015 Oct;36(10):4004-15
26248582
Cereb Cortex. 2015 Nov;25(11):4094-102
24904065
J Child Neurol. 2016 May;31(6):784-96
26661481
Neurotherapeutics. 2014 Jan;11(1):161-5
24043501
Neurosurg Focus. 2013 Nov;35(5):E4
24175864
Hum Brain Mapp. 2014 Nov;35(11):5379-88
24862742
Cortex. 2016 Mar;76:104-20
26874940
Neuroimage. 2016 Apr 1;129:308-19
26794640
Cereb Cortex. 2014 Jan;24(1):174-85
23048018
Brain Stimul. 2015 Mar-Apr;8(2):253-9
25465291
J Neural Transm (Vienna). 2009 May;116(5):623-9
19399368
Bratisl Lek Listy. 2014;115(10 ):635-42
25573731
Psychiatry Res. 2015 Sep 30;233(3):488-95
26272039
Schizophr Res. 2016 Jan;170(1):80-6
26711526
Behav Neurosci. 2016 Feb;130(1):75-90
26692448
PLoS One. 2013 Jul 03;8(7):e66736
23843961
BMC Neurol. 2011 Dec 02;11:151
22136635
PLoS One. 2013;8(2):e57425
23437385
Neuroimage. 2015 Jun;113:101-10
25800212
J Child Neurol. 2016 Jun;31(7):918-24
26879095
Hum Brain Mapp. 2014 Jul;35(7):3083-94
24123508
Front Syst Neurosci. 2015 Mar 10;9:24
25805975
Neuroimage. 2011 Jun 15;56(4):2249-57
21459149
CNS Neurosci Ther. 2012 Jan;18(1):34-40
21143432
Pain Med. 2016 Apr;17 (4):737-45
26814276
Neuropsychopharmacology. 2011 Jul;36(8):1575-86
21451498
Ger Med Sci. 2010 Apr 19;8:Doc09
20421953
Front Hum Neurosci. 2014 Jun 11;8:419
24966828
Psychiatry Res. 2014 Nov 30;224(2):112-8
25220159
Neurosci Lett. 2016 Feb 26;615:92-7
26797654
Psychiatry Res. 2012 Nov 30;204(2-3):161-7
23149038
Psychol Med. 2016 May;46(7):1485-96
26875722
J Atten Disord. 2015 Dec 20;:null
26689935
Psychiatry Res. 2015 Mar 30;231(3):273-8
25682468
Arch Gen Psychiatry. 2012 Sep;69(9):952-61
22945622
Hum Brain Mapp. 2014 Aug;35(8):3673-86
24453107
Biol Psychiatry. 2013 Oct 15;74(8):615-22
23731741
J Neurosci. 2013 Jul 3;33(27):11032-9
23825408
Neuroreport. 2016 Apr 13;27(6):422-6
26963166
Neuron. 2014 Nov 5;84(3):638-54
25442941
Front Syst Neurosci. 2016 Feb 22;10:12
26941618