miRNAs in non-alcoholic fatty liver disease.
Non-alcoholic fatty liver disease (NAFLD) is a major cause of liver cirrhosis and hepatocellular carcinoma and is a considerable threat to public health. miRNAs are important post-transcriptional regulators of gene expression, and the dysregulation of miRNAs is involved in various biological processes in the liver, including lipid homeostasis, inflammation, apoptosis, and cell proliferation. Recently, a number of studies have described the association between miRNAs and NAFLD progression and have shown that circulating miRNAs reflect histological changes in the liver. Therefore, circulating miRNAs have potential use for the evaluation of NAFLD severity. In this review, we discuss the involvement of miRNAs in NAFLD pathogenesis and the key role of miRNAs in the screening, diagnosis, and staging of NAFLD.
Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Zhen
Z
He
Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China. alfredhc@sjtu.edu.cn.
Cheng
C
Hu
Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Weiping
W
Jia
D000818:Animals; D015415:Biomarkers / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000209:etiology; D018450:Disease Progression; D005786:Gene Expression Regulation; D006801:Humans; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000209:etiology; D008113:Liver Neoplasms / Q000209:etiology; D051379:Mice; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics*; D065626:Non-alcoholic Fatty Liver Disease / Q000175:diagnosis* / Q000235:genetics*; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
D015415:Biomarkers; D035683:MicroRNAs
hepatocellular carcinoma; miRNA; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis
Lab Invest. 2010 Oct;90(10):1437-46
20548288
Hepatology. 2014 Aug;60(2):554-64
24677249
PLoS One. 2014 Dec 03;9(12):e113651
25470250
Clin Chim Acta. 2013 Sep 23;424:99-103
23727030
Gut. 2016 Nov;65(11):1850-1860
26282675
Annu Rev Nutr. 2011 Aug 21;31:49-63
21548778
PLoS One. 2014 Aug 20;9(8):e105192
25141008
PLoS One. 2011;6(8):e23937
21886843
Hepatology. 2014 Feb;59(2):483-95
23996730
J Cell Mol Med. 2016 Feb;20(2):204-16
26648452
J Hepatol. 2013 Apr;58(4):785-91
23211317
Liver Int. 2016 Sep;36(9):1383-91
26945479
ScientificWorldJournal. 2013;2013:481893
23576902
Am J Physiol Gastrointest Liver Physiol. 2006 May;290(5):G852-8
16603729
Sci Rep. 2015 Sep 02;5:13729
26330104
Int J Mol Med. 2015 Mar;35(3):847-53
25605429
Trends Endocrinol Metab. 2012 Feb;23(2):65-72
22154484
Cell Cycle. 2012 Mar 1;11(5):922-33
22333591
World J Gastroenterol. 2014 Jun 21;20(23 ):7392-402
24966609
EMBO Mol Med. 2014 Jul 18;6(9):1133-41
25038053
Hepatology. 2009 Apr;49(4):1176-84
19072831
BMC Cancer. 2016 Jan 05;16:3
26728044
J Lipid Res. 2009 Sep;50(9):1756-65
19372595
J Clin Invest. 2012 Aug;122(8):2884-97
22820290
Liver Int. 2015 Feb;35(2):532-41
25040043
Proc Natl Acad Sci U S A. 2011 May 31;108(22):9232-7
21576456
Nat Commun. 2015 Jun 23;6:7466
26100857
Hepatology. 2009 Oct;50(4):1152-61
19711427
Nature. 2011 Oct 19;478(7369):404-7
22012398
Science. 2010 Jun 18;328(5985):1566-9
20466882
Cell Death Dis. 2015 Jul 23;6:e1833
26203862
Mol Nutr Food Res. 2012 Nov;56(11):1665-74
22968990
J Appl Toxicol. 2014 Jun;34(6):726-32
24217942
J Clin Invest. 2002 May;109(9):1125-31
11994399
Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):328-36
21071704
Hepatology. 2015 Jan;61(1):141-52
25131933
Lancet Diabetes Endocrinol. 2014 Nov;2(11):901-10
24731669
Gastroenterology. 2012 Jun;142(7):1431-43
22504185
J Hepatol. 2015 Dec;63(6):1466-75
26272872
Hepatology. 2008 Dec;48(6):1810-20
19030170
Dig Dis Sci. 2016 May;61(5):1314-24
26769057
Biochem Biophys Res Commun. 2011 Nov 4;414(4):664-9
21986524
Gut. 2015 May;64(5):800-12
24973316
World J Hepatol. 2014 Aug 27;6(8):613-20
25232454
Am J Physiol Gastrointest Liver Physiol. 2015 Feb 15;308(4):G298-312
25501551
Biochimie. 2013 Jul;95(7):1355-9
23542596
Hepatology. 2016 Jul;64(1):73-84
26707365
Cell Metab. 2006 Feb;3(2):87-98
16459310
Liver Int. 2014 Aug;34(7):e302-7
24313922
Aliment Pharmacol Ther. 2011 Aug;34(3):274-85
21623852
Gut. 2016 Nov;65(11):1882-1894
26338827
Sci Rep. 2015 Aug 06;5:12911
26246194
Atherosclerosis. 2015 Mar;239(1):192-202
25617860
Clin Chim Acta. 2015 Jun 15;446:267-71
25958847
Cell Tissue Res. 2012 Aug;349(2):405-13
22622804
Mol Cell Biol. 2001 Feb;21(4):1393-403
11158324