Fibromodulin: A regulatory molecule maintaining cellular architecture for normal cellular function.
Fibromodulin (FMOD) is a small leucine-rich proteoglycan that plays roles in a series of biological and pathophysiological processes. The interaction between FMOD and lysyl oxidase (LOX; collagen cross-linking enzyme) helps regulate extracellular matrix composition, and thereby, provides a permissive environment for regulating cellular turnover. FMOD has been mostly studied in the context of matrix component assembly, but during recent years its association with muscle development, cell reprogramming, and the angiogenic program have demonstrated its activities well beyond extracellular matrix maintenance. In fact, the involvement of FMOD in these cellular processes places it the centrum of cellular behaviour and ultimately of tissue properties. Thus, a clear view of the impact FMOD has on tissue integrity would aid its exploitation for tissue modelling and in the treatment of different disorders.
Department of Medical Biotechnology, Yeungnam University, Gyeongsan, 38541, Republic of Korea.
Arif Tasleem
AT
Jan
Department of Medical Biotechnology, Yeungnam University, Gyeongsan, 38541, Republic of Korea.
Eun Ju
EJ
Lee
Department of Medical Biotechnology, Yeungnam University, Gyeongsan, 38541, Republic of Korea. Electronic address: inhochoi@ynu.ac.kr.
Inho
I
Choi
D000818:Animals; D002477:Cells / Q000166:cytology* / Q000378:metabolism*; D004194:Disease; D000071235:Fibromodulin / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D021381:Protein Transport
D000071235:Fibromodulin
Cellular structure; Extracellular matrix; Fibromodulin; Proteoglycans