Chitosan/Mimosa tenuiflora films as potential cellular patch for skin regeneration.
Bio-composites films were prepared by casting and drying of aqueous solutions containing different weight ratios of chitosan and bark of Mimosa tenuiflora. The physico-chemical and functional properties of the films were characterized by scanning electron microscopy, dynamical mechanical analysis, wettability, cytotoxicity and in vitro antibacterial activities. The morphology studies confirmed that the presence of Mimosa tenuiflora change the surface of films. Moreover, the incorporation of Mimosa tenuiflora improved the thermal stability of the films, as it was indicated by the changes in the glass temperatures obtained. Water-uptake ability changed in relation to polymeric composition of film. This property increased by the addition of Mimosa tenuiflora to the film. Improved antibacterial properties were measured against Escherichia Coli and Micrococcus lysodeikticus or luteus. Finally, cytotoxicity was studied by MTT assay and the films were non-toxic. These preliminary results provide a cheap way to prepare chitosan/Mimosa tenuiflora films for wound healing and skin regeneration.
Instituto de Ingeniería y Tecnología, Universidad Autónoma de Ciudad Juárez, Ave. Del Charro #610 norte, Col. Partido Romero, C.P.32320, Cd. Juárez, Chihuahua, Mexico. Electronic address: takeru-89@hotmail.com.
Laura Elizabeth
LE
Valencia-Gómez
Instituto de arquitectura diseño y arte, Universidad Autónoma de Ciudad Juárez, Ave. Del Charro #610 norte, Col. Partido Romero, C.P.32320, Cd. Juárez, Chihuahua, Mexico. Electronic address: adriana.martel@uacj.mx.
Santos Adriana
SA
Martel-Estrada
Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Anillo envolvente del PRONAF y Estocolmo, C.P.32320, Cd. Juárez, Chihuahua, Mexico. Electronic address: cvargas@uacj.mx.
Claudia
C
Vargas-Requena
Centro de investigación en petroquímica secundaria, Instituto tecnológico de Ciudad Madero. Prol. Bahia de Aldair y Ave. De las Bahias, parque de la pequeña y media industria, 89600 Altamira, Tams.
José Luis
JL
Rivera-Armenta
Instituto de Ingeniería y Tecnología, Universidad Autónoma de Ciudad Juárez, Ave. Del Charro #610 norte, Col. Partido Romero, C.P.32320, Cd. Juárez, Chihuahua, Mexico. Electronic address: ngalba@miners.utep.edu.
Noe
N
Alba-Baena
Instituto de Ingeniería y Tecnología, Universidad Autónoma de Ciudad Juárez, Ave. Del Charro #610 norte, Col. Partido Romero, C.P.32320, Cd. Juárez, Chihuahua, Mexico. Electronic address: claudia.rodriguez@uacj.mx.
Claudia
C
Rodríguez-González
Instituto de Ingeniería y Tecnología, Universidad Autónoma de Ciudad Juárez, Ave. Del Charro #610 norte, Col. Partido Romero, C.P.32320, Cd. Juárez, Chihuahua, Mexico. Electronic address: iolivas@uacj.mx.
Imelda
I
Olivas-Armendáriz
D016475:3T3 Cells; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D001458:Bandages; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D048271:Chitosan / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D004926:Escherichia coli / Q000187:drug effects; D051379:Mice; D008837:Micrococcus / Q000187:drug effects; D031298:Mimosa / Q000737:chemistry*; D012038:Regeneration / Q000187:drug effects*; D012867:Skin / Q000187:drug effects*; D057968:Transdermal Patch; D017155:Wettability
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D048271:Chitosan
Chitosan; Film; Mimosa tenuiflora; Skin