[Analysis of association of human 8-oxoguanine giycosylase 1 polymorphism with the susceptibility of laryngeal cancer].
Objective:To study the association between human 8-oxoguanine giycosylase 1 (hOGG1) gene polymorphisms and the risk of laryngeal carcinoma.Methods:A total of 86 patients with laryngeal carcinoma treated in The Air Force General Hospital and the Bozhou People's Hospital of Anhui Province from Jan 2010 to Dec 2014 were included in experimental group, and 86 healthy adults were selected as control group. The hOGG1 gene polymorphisms of subjects in two group were detected with by polymerase chain reaction amplification and gene sequencing technology, the differences in hOGG1 gene polymorphisms between two groups were analyzed.Results:The frequencies of hOGG1 gene heterozygous type (Ser/Cys) and mutant type (Cys/Cys) in experimental group were higher than those in control group(P<0.05). Compared to individuals with hOGG1 gene Ser/Ser, individuals with hOGG1 gene Ser/Cys had a 2.97-fold increased risk of laryngeal carcinoma, and individuals with hOGG1 gene Cys/Cys had a 8.09-fold increased risk of laryngeal carcinoma. Stratified by smoking or not, it was found that the proportion of heterozygous type or mutant type in smokers was higher significantly than non-smokers (P<0.05).Conclusion:Individuals with hOGG1 gene heterozygous type (Ser/Cys) or mutant type (Cys/Cys) have a higher risk of laryngeal carcinoma, with interaction between these gene types and smoking, and the gene types could be used as predictors for the occurrence of laryngeal carcinoma.
Department of Otorhinolaryngology Head and Neck Surgery, Bozhou People's Hospital, Bozhou 236800, China.
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DP
Li
Department of Otorhinolaryngology Head and Neck Surgery, Bozhou People's Hospital, Bozhou 236800, China.
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H
Huang
Department of Otorhinolaryngology Head and Neck Surgery, Bozhou People's Hospital, Bozhou 236800, China.
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W
Chai
Department of Otorhinolaryngology Head and Neck Surgery, Bozhou People's Hospital, Bozhou 236800, China.
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M
He
Department of Otorhinolaryngology Head and Neck Surgery, the Air Force General Hospital, Beijing 100142, China.
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J
Deng
Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Air Force Institute of aviation medicine, Beijing 100089, China.
H L
HL
Zhang
Department of Otorhinolaryngology Head and Neck Surgery, the Air Force General Hospital, Beijing 100142, China.
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R
Guo
D000328:Adult; D016022:Case-Control Studies; D045647:DNA Glycosylases / Q000235:genetics*; D005260:Female; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007822:Laryngeal Neoplasms / Q000201:enzymology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012907:Smoking / Q000009:adverse effects / Q000378:metabolism
D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human