Crystalline keratopathy due to intravenous immunoglobulin in a 12-year-old girl with Kawasaki disease.
Kawasaki disease (KD) is an acute, self-limiting, medium-vessel vasculitis that occurs predominantly in young children. The treatment of KD consists of intravenous immunoglobulin (IVIG) along with aspirin and, in IVIG-resistant cases, corticosteroids. Crystalline keratopathy with corneal deposition of the immunoglobulin is a rare complication of IVIG therapy. We report the case of a 12-year-old girl who received IVIG for KD and developed visual complaints, which were attributable to crystalline keratopathy and corneal edema. Cessation of IVIG and treatment with topical and systemic corticosteroids reversed the finding. At final follow-up, vision in both eyes was normal.
Pediatric Rheumatology Clinic, Department of Pediatrics, Jupiter Hospitals, Thane, Maharashtra, India.
Vijay
V
Viswanathan
Advanced Eye Hospital & Institute, Navi Mumbai, Maharashtra, India.
Prachi
P
Agashe
Advanced Eye Hospital & Institute, Navi Mumbai, Maharashtra, India.
Vandana
V
Jain
Advanced Eye Hospital & Institute, Navi Mumbai, Maharashtra, India; Lokmanya Tilak Municipal Medical College & General Hospital, Sion, Mumbai, India. Electronic address: akshaygn@gmail.com.
Akshay Gopinathan
AG
Nair
D002648:Child; D003316:Corneal Diseases / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000009:adverse effects* / Q000627:therapeutic use; D007155:Immunologic Factors / Q000009:adverse effects* / Q000627:therapeutic use; D009080:Mucocutaneous Lymph Node Syndrome / Q000188:drug therapy*; D041623:Tomography, Optical Coherence; D014786:Vision Disorders / Q000139:chemically induced* / Q000175:diagnosis; D014792:Visual Acuity / Q000502:physiology
D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors