IL28B gene variants and glucose metabolism in Type 2 Diabetes.
Type 2 Diabetes (T2D) develops, when β-cell insulin response fails to compensate for insulin resistance. Recent studies reported associations between the IL28B polymorphisms (rs12979860 and rs8099917) and T2D development in Hepatitis C virus (HCV) patients. To identify possible association with T2D independent from virus infection, we investigated both IL28B polymorphisms in T2D patients and healthy controls (HC). No association was found comparing the genotype and allele frequencies of both IL28B polymorphisms between T2D patients and HC. However, higher glucose levels were found in T2D patients carrying the IL28B CT/TT rs12979860 and GT/GG rs8099917 HCV risk genotypes compared to those with the protective CC and TT genotype (p=0.06 and p=0.02, respectively). Moreover, T2D patients with CT/TT rs12979860 HCV risk genotypes possessed significantly higher HbA1c levels than CC carriers (p=0.04). In conclusion, the IL28B HCV risk genotypes may influence glucose homeostasis in T2D patients without HCV.
Department of Internal Medicine I, Division of Endocrinology, Diabetes and Metabolism, University Frankfurt, Frankfurt am Main, Germany. Electronic address: yasmin_moran@gmx.de.
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Morán-Auth
Department of Internal Medicine I, Division of Endocrinology, Diabetes and Metabolism, University Frankfurt, Frankfurt am Main, Germany.
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Penna-Martinez
Department of Internal Medicine I, Division of Endocrinology, Diabetes and Metabolism, University Frankfurt, Frankfurt am Main, Germany.
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Perner
Department of Internal Medicine I, Division of Endocrinology, Diabetes and Metabolism, University Frankfurt, Frankfurt am Main, Germany.
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Susser
Occupational Health Service, University Frankfurt, Frankfurt am Main, Germany.
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Wicker
Department of Internal Medicine I, Division of Endocrinology, Diabetes and Metabolism, University Frankfurt, Frankfurt am Main, Germany.
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Zeuzem
Department of Internal Medicine I, Division of Endocrinology, Diabetes and Metabolism, University Frankfurt, Frankfurt am Main, Germany.
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Sarrazin
Department of Internal Medicine I, Division of Endocrinology, Diabetes and Metabolism, University Frankfurt, Frankfurt am Main, Germany.
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Badenhoop
D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D005858:Germany; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007372:Interferons; D007378:Interleukins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D000095022:Interferon Lambda
D005947:Glucose; D007372:Interferons; D007378:Interleukins; C000624353:interferon-lambda, human; D000095022:Interferon Lambda
Glucose; HOMA-IR; IL28B; T2D