Blood flow boosts BMP signaling to keep vessels in shape.
Bone morphogenic proteins (BMPs) and blood flow regulate vascular remodeling and homeostasis. In this issue, Baeyens et al. (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201603106) show that blood flow sensitizes endothelial cells to BMP9 signaling by triggering Alk1/ENG complexing to suppress cell proliferation and to recruit mural cells, thereby establishing endothelial quiescence.
Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.
Claudio A
CA
Franco
Max-Delbrück Center for Molecular Medicine, 13125 Berlin, Germany Department of Oncology, Vascular Patterning Laboratory, Vesalius Research Center, 3000 Leuven, Belgium German Center for Cardiovascular Research, 13347 Berlin, Germany Berlin Institute of Health, 10117 Berlin, Germany holger.gerhardt@mdc-berlin.de.
Holger
H
Gerhardt
D000818:Animals; D001808:Blood Vessels / Q000378:metabolism* / Q000473:pathology*; D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D012039:Regional Blood Flow; D015398:Signal Transduction
D019485:Bone Morphogenetic Proteins
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