Pleiotropic regulations of neutrophil receptors response to sepsis.
BACKGROUND
Sepsis is a complex clinical condition that causes a high mortality rate worldwide. Numerous studies on the pathophysiology of sepsis have revealed an imbalance in the inflammatory network, thus leading to tissue damage, organ failure, and ultimately death. The impairment of neu-trophil migration is associated with the outcome of sepsis.


METHODS
Literature review was performed on the roles of neutrophil recruitment and neutrophil receptors as pleiotropic regulators during sepsis. Additionally, we systematically classify neutrophil receptors with regard to the neutrophil response during sepsis and discuss the clinical implications of these receptors for the treatment of sepsis.


RESULTS
Increasing evidence suggests that there is significant dysfunction in neutrophil recruitment during sepsis, characterized by the failure to migrate to the site of infection. Neutrophil receptors, as pleiotropic regulators, play important roles in the neutrophil response during sepsis.


CONCLUSIONS
Neutrophil receptors play key roles in chemotactic neutrophil migration and may prove to be suitable targets in future pharmacological therapies for sepsis.
Department of Burns and Plastic Surgery, Affiliated Hospital, Jiangsu University, Zhenjiang, 212001, Jiangsu, China.
Huafeng
H
Zhang
Department of Burns and Plastic Surgery, Affiliated Hospital, Jiangsu University, Zhenjiang, 212001, Jiangsu, China. sunbinwe@hotmail.com.
Bingwei
B
Sun
D000818:Animals; D002634:Chemotaxis, Leukocyte; D006801:Humans; D020556:Neutrophil Infiltration; D009504:Neutrophils / Q000276:immunology* / Q000502:physiology; D011971:Receptors, Immunologic / Q000276:immunology*; D018805:Sepsis / Q000276:immunology*
D011971:Receptors, Immunologic
Neutrophil; Receptor; Response; Sepsis
J Immunol. 2003 Mar 15;170(6):3059-64
12626561
Immunol Rev. 2002 Aug;186:37-46
12234360
Expert Rev Clin Immunol. 2014 Aug;10(8):1019-28
24867165
J Leukoc Biol. 2016 Nov;100(5):999-1004
27059842
Ann Rheum Dis. 2008 Dec;67 Suppl 3:iii70-4
19022819
Shock. 2012 May;37(5):539-47
22392143
Blood. 2006 Nov 1;108(9):2906-13
16849637
Immunol Today. 2000 May;21(5):206-9
10782049
Nat Immunol. 2012 Mar 25;13(5):457-64
22447027
Cardiovasc Hematol Disord Drug Targets. 2015;15(1):19-28
25567338
J Infect Dis. 2002 Aug 1;186(3):341-50
12134230
J Immunol. 2001 Apr 15;166(8):5108-14
11290792
Cancer Metastasis Rev. 2006 Sep;25(3):387-408
17043764
Am J Respir Crit Care Med. 2007 Mar 1;175(5):490-7
17138957
PLoS One. 2012;7(5):e37584
22655058
JAMA. 2013 Mar 20;309(11):1154-62
23512062
Naunyn Schmiedebergs Arch Pharmacol. 2013 Jan;386(1):51-9
23187752
J Exp Med. 2008 Jun 9;205(6):1277-83
18474631
Thromb Haemost. 2007 Aug;98 (2):262-73
17721605
J Leukoc Biol. 2011 May;89(5):675-83
21169518
Nat Med. 2010 Jun;16(6):708-12
20473304
Nat Rev Immunol. 2006 Mar;6(3):173-82
16498448
Trends Pharmacol Sci. 2012 Mar;33(3):154-64
22277298
Nat Med. 2003 Mar;9(3):315-21
12592402
Am J Pathol. 2010 May;176(5):2352-66
20304963
N Engl J Med. 2006 Feb 9;354(6):610-21
16467548
Shock. 2008 Oct;30 Suppl 1:3-9
18704017
Immunity. 2012 Oct 19;37(4):747-58
23063331
Blood. 2004 Aug 15;104(4):1100-9
15113757
Eur J Immunol. 2005 Aug;35(8):2486-95
16025565
J Immunol. 2007 Sep 15;179(6):3937-46
17785831
Crit Care Med. 2012 Sep;40(9):2631-7
22732279
J Cell Physiol. 2011 Mar;226(3):627-37
20717897
Nat Immunol. 2000 Sep;1(3):227-33
10973280
Curr Opin Infect Dis. 2012 Jun;25(3):321-7
22421753
J Immunol. 2004 Jul 1;173(1):428-36
15210802
Curr Top Microbiol Immunol. 2006;311:1-16
17048703
Immunol Rev. 2009 Jul;230(1):75-96
19594630
J Clin Invest. 2006 Sep;116(9):2532-42
16917541
Am J Respir Crit Care Med. 2010 Sep 15;182(6):762-73
20508212
Med Gas Res. 2013 Jan 07;3(1):1
23295066
J Immunol. 1999 Feb 15;162(4):2341-6
9973513
Eur J Pharmacol. 2005 Apr 4;512(1):1-8
15814083
J Hepatol. 2006 May;44(5):939-46
16458386
Int J Mycobacteriol. 2014 Mar;3(1):17-24
26786218
Nat Rev Immunol. 2004 Feb;4(2):133-42
15040586
Blood. 2003 Oct 1;102(7):2660-9
12829592
J Immunol. 2012 Jul 1;189(1):287-95
22661085
Curr Opin Hematol. 2010 Jan;17(1):18-24
19864946
Eur J Clin Invest. 2013 Jul;43(7):740-5
23594336
Nat Med. 2007 May;13(5):587-96
17435771
Annu Rev Immunol. 2012;30:459-89
22224774
Proc Natl Acad Sci U S A. 2009 Mar 10;106(10 ):4018-23
19234125
J Cell Sci. 2008 Jan 15;121(Pt 2):205-14
18187452
J Immunol. 2006 Jul 15;177(2):1264-71
16818786
J Atheroscler Thromb. 2013;20(6):585-90
23665840
J Infect Dis. 2000 Jul;182(1):214-23
10882600
J Biol Chem. 2010 Mar 5;285(10 ):7633-44
20044484
Nat Med. 2008 May;14(5):551-7
18454156
Nitric Oxide. 2006 Aug;15(1):77-86
16621629
World J Gastroenterol. 2012 Jul 28;18(28):3635-61
22851857
Ann Surg. 2002 Apr;235(4):550-9
11923612
Intensive Care Med. 2004 Apr;30(4):605-11
14991094
Infect Immun. 2007 Aug;75(8):3989-98
17526745
Cell Signal. 2006 Oct;18(10):1732-47
16530386
Int J Clin Lab Res. 1998;28(3):148-61
9801925
J Immunol. 1990 Oct 15;145(8):2639-43
2170522
Biochem J. 2008 Jan 15;409(2):349-55
18092947
Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9237-42
11470918
J Immunol. 2001 Aug 15;167(4):2312-22
11490020
Anesthesiology. 2011 Sep;115(3):555-67
21792053
Blood. 2008 Nov 15;112(10):4250-8
18535203
Immunol Cell Biol. 2008 Feb;86(2):153-60
18227853
Infect Immun. 2011 Jul;79(7):2865-70
21576343
PLoS Pathog. 2012;8(4):e1002641
22496659
J Immunol. 2010 Jun 1;184(11):6327-34
20421642
J Exp Med. 2005 Apr 18;201(8):1183-9
15824084
Am J Physiol Gastrointest Liver Physiol. 2015 Jul 1;309(1):G30-41
25930080
Shock. 2003 Jan;19(1):61-5
12558146
Biochemistry. 2004 Jun 29;43(25):8204-16
15209517
Immunology. 1994 Feb;81(2):211-5
7512527
J Leukoc Biol. 2008 Mar;83(3):467-70
17875813
Nat Rev Immunol. 2013 Mar;13(3):159-75
23435331
JAMA. 2010 Oct 27;304(16):1856
20978264
J Surg Res. 2015 Feb;193(2):902-8
25439504
Cell Signal. 2003 Nov;15(11):993-1001
14499342
Crit Rev Clin Lab Sci. 2003 Dec;40(6):643-72
14708958
J Immunol. 2014 Mar 1;192(5):2357-65
24489087
J Exp Med. 1996 Jul 1;184(1):191-201
8691134
Immunity. 2007 Apr;26(4):477-489
17442598
Pharmacol Rev. 2000 Mar;52(1):145-76
10699158
Cell Host Microbe. 2013 Feb 13;13(2):169-80
23414757
Cytokine Growth Factor Rev. 2006 Dec;17(6):501-19
17084101
Mem Inst Oswaldo Cruz. 2005 Mar;100 Suppl 1:223-6
15962127
Acta Pharmacol Sin. 2012 Mar;33(3):342-50
22367283
FASEB J. 2003 Oct;17(13):1889-91
12897064
Nat Rev Immunol. 2011 Jul 25;11(8):519-31
21785456
J Immunol. 2006 Apr 15;176(8):4995-5005
16585596
Biochemistry. 2000 Sep 5;39(35):10848-54
10978171
J Immunol. 2008 Jan 1;180(1):609-17
18097063
N Engl J Med. 2013 Aug 29;369(9):840-51
23984731
Eur J Immunol. 2010 Sep;40(9):2360-8
20549669
Crit Care Med. 2006 Feb;34(2):461-70
16424729
Am J Respir Cell Mol Biol. 2014 Jan;50(1):87-95
23947598
Int Immunopharmacol. 2012 Nov;14(3):283-8
22863814
J Leukoc Biol. 2007 Jan;81(1):1-5
17032697
J Innate Immun. 2010;2(5):439-45
20588003
Trends Immunol. 2002 Nov;23(11):541-8
12401407
J Immunol. 2009 Jun 15;182(12):7855-64
19494310