One-Pot Synthesis of Chiral, Spirocyclic 4-Hydantoin-Proline Derivatives for Incorporation into Spiroligomer-Based Macromolecules.
Derivatives of 4-hydantoin-proline have been synthesized via a direct two-step alkylation method. This method is valuable in the development of applications of N,N'-disubstituted hydantoin bearing α-amino acids by improving yields, reducing the time and number of steps required to synthesize these substituted molecules, and enabling late stage functionalization of spiroligomer termini. Over 20 unique electrophiles have been tested, highlighting the inherent versatility of this chemistry.
Department of Chemistry, Temple University , Philadelphia, Pennsylvania 19122, United States.
J D
JD
Northrup
Department of Chemistry, Temple University , Philadelphia, Pennsylvania 19122, United States.
Claire R
CR
Purcell
Department of Chemistry, Temple University , Philadelphia, Pennsylvania 19122, United States.
Christian E
CE
Schafmeister