Spectral characteristics of intracranial electroencephalographic activity in patients with Lennox-Gastaut syndrome.
OBJECTIVE
The purpose of the current study was to characterize the frequency profiles of epileptogenic regions, independent of visible epileptiform discharges, in intracranial EEG (iEEG) recordings of Lennox-Gastaut syndrome (LGS) patients.


METHODS
We selected eight LGS patients who underwent resective surgery in the absence of definite neuroimaging findings. We calculated the absolute and relative band powers of continuous spike-free iEEG data and compared the characteristics of the resected and remaining regions.


RESULTS
For absolute band powers, there was a trend for higher absolute gamma band power in the remaining brain section. We also found that the absolute delta power in the resected area was higher than that in the remaining area. However, this trend was not statistically different in all patients. For relative band powers, we found decreased relative band power in the beta and gamma band ranges within the areas defined by the surgical margins. Delta, theta, and alpha relative band power differences between the resected and remaining areas were inconsistent between the subjects.


CONCLUSIONS
Our results showed systematic relative beta and gamma band power variation in the resected areas of LGS patients.
Epilepsy Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Dongpyo
D
Lee
Radio Frequency Integrated Circuit Center, Kwangwoon University, Seoul, Republic of Korea.
Junge
J
Liang
Department of Pediatrics, Haeundae Paik Hospital, Inje University College of Medicine, Pusan, Republic of Korea.
Yun Jung
YJ
Hur
Radio Frequency Integrated Circuit Center, Kwangwoon University, Seoul, Republic of Korea. Electronic address: nykim@kw.ac.kr.
Nam-Young
NY
Kim
Epilepsy Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Pediatrics, Pediatric Epilepsy Clinic, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: hdkimmd@yuhs.ac.
Heung Dong
HD
Kim
D000293:Adolescent; D001611:Beta Rhythm / Q000502:physiology; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D003700:Delta Rhythm / Q000502:physiology; D000069280:Electrocorticography; D005260:Female; D065818:Gamma Rhythm / Q000502:physiology; D006801:Humans; D065768:Lennox Gastaut Syndrome / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery*; D008297:Male; D019635:Neurosurgical Procedures; D055815:Young Adult
Frequency band power; Lennox–Gastaut syndrome; Resective surgery