Clinical evaluation of deep anterior lamellar keratoplasty using glycerol-cryopreserved corneal tissues for refractory herpetic stromal keratitis: An observational study.
The study aimed to evaluate the therapeutic effects of deep anterior lamellar keratoplasty (DALK) using glycerol-cryopreserved corneal tissues (GCCTs) in patients with refractive herpes simplex keratitis (HSK). This article was a retrospective, noncomparative, and interventional case series. Patients with HSK underwent DALK using GCCTs at Shanghai Tongji Hospital from 2012 to 2015. The best spectacle corrected visual acuity, recurrent inflammation, graft status, postoperative central graft thickness, and pre/postoperative complications were detected. The follow-up ranged from 24.4 ± 5.6 months (range: 16-38 months). Overall, the best spectacle corrected visual acuity was increased from HM/10 cm to 0.15 before surgery to 0.41 ± 0.14 (range: 0.1-0.8; P < 0.05) at 12 months postoperatively. Intraoperative microperforation occurred in 4 eyes (14.81%), and rejection episodes were encountered in 3 of 27 eyes (11.1%), and all of the eyes reversed. HSK recurred in 2 eyes (7.41%), 1 eye with repeated recurring HSK, and eventually led to perpetual corneal opacity and the patient refused a retransplantation. The mean entire corneal thickness was 0.519 ± 0.018 mm (range: 0.5-0.56 mm) and the mean graft thickness was 0.405 ± 0.033 mm (range: 0.35-0.47 mm) in the final follow-up. The DALK using GCCTs was proven to be an effective and safe therapy in treating refractory HSK.
aDepartment of Ophthalmology, Tongji Hospital Affiliated with Tongji University School of Medicine, Shanghai bDepartment of Ophthalmology, Guizhou provincial people's hospital, Guiyang, Guizhou, People's Republic of China.
Xin
X
Liu
Qi
Q
Zhou
Xinyu
X
Huang
Zhenxing
Z
Liu
Yanlong
Y
Bi
D000328:Adult; D003315:Cornea; D003318:Corneal Opacity / Q000209:etiology; D003319:Corneal Stroma / Q000473:pathology; D016039:Corneal Transplantation / Q000379:methods*; D015925:Cryopreservation / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D005990:Glycerol; D006801:Humans; D016849:Keratitis, Herpetic / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology; D012008:Recurrence; D012189:Retrospective Studies; D014021:Tissue Preservation / Q000379:methods*; D016896:Treatment Outcome; D014792:Visual Acuity; D055815:Young Adult
D005990:Glycerol
Curr Clin Top Infect Dis. 2000;20:298-324
10943530
Cornea. 2001 Jan;20(1):1-13
11188989
Am J Ophthalmol. 2002 Aug;134(2):159-65
12140020
Invest Ophthalmol Vis Sci. 1992 Jul;33(8):2470-5
1321797
Trans Am Ophthalmol Soc. 1961;59:194-201
14456106
Chin Med J (Engl). 1992 Jul;105(7):603-8
1451568
Expert Rev Mol Med. 2004 Mar 30;6(8):1-14
15061872
Ophthalmology. 2004 Sep;111(9):1676-82
15350322
Cornea. 2005 Mar;24(2):241-3
15725898
Ophthalmology. 2005 May;112(5):888-95
15878072
Ophthalmology. 2006 Apr;113(4):556-60
16581417
Prog Retin Eye Res. 2006 Jul;25(4):355-80
16807055
Cornea. 2007 Jan;26(1):59-64
17198015
Ophthalmology. 2009 Apr;116(4):615-23
19243833
Clin Ophthalmol. 2007 Dec;1(4):441-53
19668521
Invest Ophthalmol Vis Sci. 2010 Feb;51(2):775-81
19737874
Cornea. 2010 Jan;29(1):60-4
19907304
Br J Ophthalmol. 2010 Oct;94(10):1300-3
20554507
Am J Ophthalmol. 2011 Nov;152(5):762-70.e3
21803324
Am J Ophthalmol. 2012 Feb;153(2):291-299.e2
21996306
Graefes Arch Clin Exp Ophthalmol. 2012 Aug;250(8):1187-94
22349979
Cornea. 2012 Jun;31(6):621-6
22406938
Int J Ophthalmol. 2013 Apr 18;6(2):251-2
23638432
Med J Armed Forces India. 2013 Jan;69(1):21-6
24532929
J Ophthalmol. 2014;2014:209759
25105019
PLoS One. 2014 Dec 01;9(12):e113843
25438169
Int J Clin Exp Med. 2015 Jun 15;8(6):9446-53
26309607
Cornea. 2016 Jan;35(1):1-5
26562819
Oman J Ophthalmol. 2015 May-Aug;8(2):83-5
26622133
Arch Ophthalmol. 1989 Aug;107(8):1155-9
2787981
Eye (Lond). 1988;2 ( Pt 4):400-8
3075567
Science. 1971 Aug 27;173(3999):843-5
4328483
Trans Am Ophthalmol Soc. 1984;82:106-10
6398932
Arch Ophthalmol. 1980 Oct;98(10):1755-9
7000050
Br J Ophthalmol. 1997 Mar;81(3):184-8
9135380