The Role of Bioactive Dietary Components in Modulating miRNA Expression in Colorectal Cancer.
Colorectal cancer is the third most common cancer in the world and considered to be one of the most diet-related types of cancer. Extensive research has been conducted but still the link between diet and colorectal cancer is complex. Recent studies have highlight microRNAs (miRNAs) as key players in cancer-related pathways in the context of dietary modulation. MicroRNAs are involved in most biological processes related to tumor development and progression; therefore, it is of great interest to understand the underlying mechanisms by which dietary patterns and components influence the expression of these powerful molecules in colorectal cancer. In this review, we discuss relevant dietary patterns in terms of miRNAs modulation in colorectal cancer, as well as bioactive dietary components able to modify gene expression through changes in miRNA expression. Furthermore, we emphasize on protective components such as resveratrol, curcumin, quercetin, α-mangostin, omega-3 fatty acids, vitamin D and dietary fiber, with a focus on the molecular mechanisms in the context of prevention and even treatment. In addition, several bioactive dietary components that have the ability to re-sensitize treatment resistant cells are described.
Department of Bromatology, Hygiene, Nutrition, University of Medicine and Pharmacy "Iuliu Hatieganu", Marinescu Street 23, Cluj-Napoca 400337, Romania. laura.biris@umfcluj.ro.
Laura I
LI
Gavrilas
Department of Pharmaceutical Biochemistry and Clinical Laboratory, University of Medicine and Pharmacy "Iuliu Hatieganu", Louis Pasteur Street 6, Cluj-Napoca 400349, Romania. inaionescu@yahoo.com.
Corina
C
Ionescu
Department of Functional Genomics, Proteomics and Experimental Pathology, The Oncology Institute "Prof. Dr. Ion Chiricuta", Republicii Street 34-36, Cluj-Napoca 400015, Romania. oana.tudoran@iocn.ro.
Oana
O
Tudoran
Department of Surgical and Gynecological Oncology, University of Medicine and Pharmacy "Iuliu Hatieganu", Republicii Street 34-36, Cluj-Napoca 400015, Romania. cosminlisencu@yahoo.com.|Department of Surgery, The Oncology Institute "Prof. Dr. Ion Chiricuta", Republicii Street 34-36, Cluj-Napoca 400015, Romania. cosminlisencu@yahoo.com.
Cosmin
C
Lisencu
Department of Functional Genomics, Proteomics and Experimental Pathology, The Oncology Institute "Prof. Dr. Ion Chiricuta", Republicii Street 34-36, Cluj-Napoca 400015, Romania. ovidiubalacescu@iocn.ro.
Ovidiu
O
Balacescu
Department of Bromatology, Hygiene, Nutrition, University of Medicine and Pharmacy "Iuliu Hatieganu", Marinescu Street 23, Cluj-Napoca 400337, Romania. dmiere@umfcluj.ro.
Doina
D
Miere
bioactive dietary components; colorectal cancer; diet; microRNA
World J Gastroenterol. 2014 Dec 7;20(45):17011-9
25493013
Cancer Res. 2008 Jun 1;68(11):4123-32
18519671
Int J Cancer. 2015 Mar 1;136(5):E359-86
25220842
Nat Rev Genet. 2010 Sep;11(9):597-610
20661255
Br J Nutr. 2004 Sep;92 (3):347-55
15469638
Maturitas. 2015 Mar;80(3):258-64
25619144
Cold Spring Harb Symp Quant Biol. 2006;71:129-34
17381288
Meat Sci. 2014 Aug;97(4):583-96
24769880
Eur J Cancer. 2010 Sep;46(14):2555-62
20843485
Apoptosis. 2008 Nov;13(11):1368-77
18785011
Carcinogenesis. 2009 Jun;30(6):953-9
19372139
EMBO J. 2004 Oct 13;23(20):4051-60
15372072
Cancer Biol Ther. 2007 Oct;6(10):1621-6
17932462
N Engl J Med. 2008 Dec 18;359(25):2641-50
19092150
Semin Oncol. 2011 Dec;38(6):724-33
22082758
J Nutr Biochem. 2015 Jul;26(7):776-83
25882694
Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2999-3004
14973191
Annu Rev Nutr. 2014;34:305-36
25033062
World J Gastrointest Oncol. 2016 Apr 15;8(4):330-40
27096028
J Soc Integr Oncol. 2006 Winter;4(1):21-6
16737669
Clin Immunol. 1999 Nov;93(2):152-61
10527691
Physiol Genomics. 2011 May 1;43(10):640-54
21406606
Eur J Cancer. 2013 Apr;49(6):1374-403
23485231
PLoS One. 2012;7(12 ):e51655
23272133
Leukemia. 2011 Aug;25(8):1324-34
21502955
Anticancer Res. 2016 Mar;36(3):1093-102
26977004
Carcinogenesis. 2014 Dec;35(12):2778-86
25280562
Nature. 2003 Sep 25;425(6956):415-9
14508493
Mol Cancer Res. 2011 Jul;9(7):960-75
21653642
Oncology. 2007;72(5-6):397-402
18196926
Carcinogenesis. 2013 Dec;34(12):2814-22
23996930
J Nutr Biochem. 2015 Mar;26(3):250-8
25533906
Nat Cell Biol. 2007 Jun;9(6):654-9
17486113
Br J Cancer. 2009 Aug 18;101(4):707-14
19672269
Biol Pharm Bull. 2006 May;29(5):903-6
16651716
Mol Cell. 2010 Oct 22;40(2):323-32
20965425
Clujul Med. 2015;88(4):453-6
26733742
Mol Nutr Food Res. 2008 Jun;52 Suppl 1:S103-27
18496811
Fitoterapia. 2011 Jun;82(4):557-69
21262328
Bioorg Med Chem. 2007 Aug 15;15(16):5620-8
17553685
Mol Carcinog. 2011 May;50(5):370-82
21480390
Am J Clin Nutr. 2010 Sep;92(3):471-90
20729339
J Nutr Biochem. 2009 Feb;20(2):106-14
18479896
Am J Epidemiol. 2016 Jul 1;184(1):23-32
27267948
Angew Chem Int Ed Engl. 2012 May 29;51(22):5308-32
22566109
Science. 2004 Jan 2;303(5654):95-8
14631048
Mol Cell. 2007 Jun 8;26(5):745-52
17540599
Mol Nutr Food Res. 2013 Feb;57(2):203-11
23239542
J Cancer. 2016 Jan 05;7(3):232-40
26918035
Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2257-61
16461460
Biochem Biophys Res Commun. 2005 Mar 4;328(1):227-34
15670774
Front Genet. 2012 Dec 28;3:305
23293655
Cancer Detect Prev. 2003;27(1):55-66
12600418
Mol Nutr Food Res. 2013 Sep;57(9):1638-48
23471840
Nat Rev Genet. 2008 Feb;9(2):102-14
18197166
J Transl Med. 2012 Jun 20;10:128
22716183
J Hum Nutr Diet. 2016 Dec;29(6):757-767
27412573
Trends Cell Biol. 2008 Oct;18(10):505-16
18774294
Int J Mol Med. 2014 Apr;33(4):863-9
24535669
Ann Surg Oncol. 2008 Jul;15(7):1918-22
18392660
Clin Cancer Res. 2008 Apr 1;14(7):2128-36
18381954
Med Oncol. 2010 Dec;27(4):1114-8
19908170
PLoS One. 2014 Apr 14;9(4):e94765
24732966
Anticancer Res. 2009 Aug;29(8):3185-90
19661333
Genes Dev. 2004 Mar 1;18(5):504-11
15014042
N Engl J Med. 2005 Oct 27;353(17):1793-801
16251535
PLoS One. 2011 Jan 20;6(1):e16221
21283757
Int J Colorectal Dis. 2011 Nov;26(11):1415-22
21739196
Nutr Rev. 2010 Jul;68(7):389-408
20591107
Hum Mol Genet. 2012 May 15;21(10):2157-65
22328083
J Cell Mol Med. 2009 Jan;13(1):39-53
19175699
J Hematol Oncol. 2012 Sep 19;5:58
22992310
Oncol Rep. 2012 Nov;28(5):1551-8
22895844
PLoS One. 2012;7(2):e30590
22363450
J Nutr Biochem. 2013 Nov;24(11):1849-58
23954321
Biosci Rep. 2011 Jun;31(3):185-97
20815812
Cell Cycle. 2011 Dec 1;10(23):4128-37
22101335
Mol Endocrinol. 2007 Nov;21(11):2785-94
17652184
Nat Rev Cancer. 2006 Apr;6(4):259-69
16557279
Oncol Rev. 2015 Dec 28;9(1):288
26779313
Mol Carcinog. 2013 Jun;52(6):459-74
22308110
Eur J Epidemiol. 2013 Apr;28(4):317-28
23579425
Arch Med Sci. 2015 Oct 12;11(5):1081-94
26528354
Trends Endocrinol Metab. 2009 Nov;20(9):452-9
19800254
Cancer Res. 1991 Jan 15;51(2):487-91
1821094
Recent Pat Food Nutr Agric. 2014;6(1):23-6
25342148
Cancer Invest. 2011 Mar;29(3):208-13
21314329
Cell. 2004 Jan 23;116(2):281-97
14744438
Gastroenterology. 2013 Aug;145(2):437-46
23619147
Altern Med Rev. 2009 Jun;14 (2):141-53
19594223
J Cell Biochem. 2008 Oct 1;105(2):546-53
18655183
J Natl Cancer Inst. 2001 Apr 4;93(7):525-33
11287446
Crit Rev Food Sci Nutr. 2015;55(1):82-93
24915407
Cell Physiol Biochem. 2015;35(6):2192-202
25896587
Cancer Prev Res (Phila). 2013 Jul;6(7):625-33
23639480
Trends Biochem Sci. 2007 Apr;32(4):189-97
17350266
Phytother Res. 2013 Mar;27(3):422-30
22628241
JAMA. 2007 Aug 15;298(7):754-64
17699009
Carcinogenesis. 2008 Jul;29(7):1415-20
18567619
J Clin Invest. 2008 Jul;118(7):2600-8
18521189
Genes Chromosomes Cancer. 2008 Nov;47(11):939-46
18663744
Gastroenterol Clin Biol. 2010 Oct;34(10):529-33
20864282
Carcinogenesis. 2009 Dec;30(12):2077-84
19825969
Oncogene. 2004 Nov 25;23(55):8979-86
15480430
J Agric Food Chem. 2010 Aug 11;58(15):8643-50
20681654
Cancer Invest. 2009 Jul;27(6):604-12
19440933
Hum Exp Toxicol. 2013 Oct;32(10):1067-80
23536519
Cancer Res. 2006 Aug 1;66(15):7390-4
16885332
Cancer Epidemiol Biomarkers Prev. 2015 Dec;24(12 ):1820-8
26396142
Rev Esc Enferm USP. 2012 Feb;46(1):234-9
22441289
Science. 2007 Dec 21;318(5858):1931-4
18048652
Genes Dev. 2004 Dec 15;18(24):3016-27
15574589
Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15472-7
17875987
PLoS Comput Biol. 2015 Nov 20;11(11):e1004612
26588727
Mol Cancer. 2009 Nov 14;8:102
19912656
Mol Cancer Ther. 2008 Mar;7(3):464-73
18347134
Biochem Pharmacol. 2010 Dec 15;80(12):2057-65
20637737
Mol Cancer. 2015 Oct 13;14:180
26463716
J Pathol. 2012 Nov;228(3):405-15
22864938
FEBS J. 2009 Apr;276(8):2348-58
19348006
J Nucleic Acids. 2011;2011:102431
21845215
BMC Cancer. 2010 May 26;10 :238
20504360
Jpn J Cancer Res. 2000 Jul;91(7):686-91
10920275
World J Gastroenterol. 2010 Mar 14;16(10):1252-7
20222170
World J Gastroenterol. 2011 Apr 28;17(16):2086-95
21547127
J Surg Oncol. 2008 Apr 1;97(5):409-15
18176914
Nat Cell Biol. 2009 Mar;11(3):228-34
19255566
Cancer Prev Res (Phila). 2014 Aug;7(8):786-95
25092886
Mol Nutr Food Res. 2012 Aug;56(8):1259-69
22641368
Oncotarget. 2015 Sep 22;6(28):25828-42
26304927
Apoptosis. 2010 May;15(5):621-30
20107900
J Gastrointestin Liver Dis. 2013 Sep;22(3):311-20
24078989
Nutr Cancer. 2013;65(3):494-504
23530649
BMJ. 2011 Nov 10;343 :d6617
22074852
Rom J Gastroenterol. 2004 Sep;13(3):187-93
15470530
Mol Cancer Ther. 2008 Oct;7(10):3330-42
18852136
Cancer Lett. 2009 Oct 18;284(1):1-6
19261378
Nature. 2004 Nov 11;432(7014):231-5
15531879
Genes Nutr. 2011 May;6(2):93-108
21516481
Reprod Toxicol. 2013 Dec;42:68-77
23954404
Exp Ther Med. 2011 Mar;2(2):181-193
22977487
Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10513-8
18663219
RNA. 2004 Feb;10(2):185-91
14730017
Int J Cancer. 2012 Jul 15;131(2):469-78
21866547
Int J Mol Sci. 2008 Mar;9(3):355-70
19325754
Gut. 2010 Jul;59(7):918-25
20348368
Oncogene. 2006 Jan 12;25(2):278-87
16170359
Cancers (Basel). 2013 Oct 21;5(4):1242-60
24202444
Biochem Pharmacol. 2012 Nov 1;84(9):1143-53
22935447
Oncogene. 2009 Mar 12;28(10 ):1385-92
19137007