Concepts in Cancer Modeling: A Brief History.
Modeling, an experimental approach to investigate complex biological systems, has significantly contributed to our understanding of cancer. Although extensive cancer research has been conducted utilizing animal models for elucidating mechanisms and developing therapeutics, the concepts in a good model design and its application have not been well elaborated. In this review, we discuss the theory underlying biological modeling and the process of producing a valuable and relevant animal model. Several renowned examples in the history of cancer research will be used to illustrate how modeling can be translatable to clinical applications. Finally, we will also discuss how the advances in cancer genomics and cancer modeling will influence each other going forward. Cancer Res; 76(20); 5921-5. ©2016 AACR.
Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland. NIH Medical Research Scholars Program, National Institutes of Health, Bethesda, Maryland.
Renee M
RM
Thomas
Center for Advanced Preclinical Research, Center for Cancer Research, National Cancer Institute, Frederick, Maryland.
Terry
T
Van Dyke
Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland. daychi@mail.nih.gov gmerlino@helix.nih.gov.
Glenn
G
Merlino
Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland. daychi@mail.nih.gov gmerlino@helix.nih.gov.
Chi-Ping
CP
Day
D000818:Animals; D060890:B7-H1 Antigen / Q000037:antagonists & inhibitors; D060908:CTLA-4 Antigen / Q000037:antagonists & inhibitors; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy / Q000209:etiology*; D048493:Proto-Oncogene Proteins B-raf / Q000037:antagonists & inhibitors / Q000502:physiology
D060890:B7-H1 Antigen; D060908:CTLA-4 Antigen; D048493:Proto-Oncogene Proteins B-raf
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