[Pulmonary arterial hypertension, bone marrow, endothelial cell precursors and serotonin].
Serotonin and bone-marrow-derived stem cells participate together in triggering pulmonary hypertension. Our work has shown that the absence of 5-HT2B receptors generates permanent changes in the composition of the blood and bone-marrow in the myeloid lineages, particularly in endothelial cell progenitors. The initial functions of 5-HT2B receptors in pulmonary arterial hypertension (PAH) are restricted to bone-marrow cells. They contribute to the differentiation/proliferation/mobilization of endothelial progenitor cells from the bone-marrow. Those bone-marrow-derived cells have a critical role in the development of pulmonary hypertension and pulmonary vascular remodeling. These data indicate that bone-marrow derived endothelial progenitors play a key role in the pathogenesis of PAH and suggest that interactions involving serotonin and bone morphogenic protein type 2 receptor (BMPR2) could take place at the level of the bone-marrow.
Laboratoire de Neurobiologie et Pharmacologie Cardiovasculaire EA7296, Faculté de Médecine, Fédération de Médecine Translationnelle de Strasbourg, Université et Centre Hospitalier de Strasbourg, Strasbourg, France.
Estelle
E
Ayme-Dietrich
INSERM UMR-S 839, Université Pierre et Marie Curie, 75005 Paris, France - Institut du Fer à Moulin, 17 rue du Fer à Moulin, 75005 Paris, France.
Sophie M
SM
Banas
Laboratoire de Neurobiologie et Pharmacologie Cardiovasculaire EA7296, Faculté de Médecine, Fédération de Médecine Translationnelle de Strasbourg, Université et Centre Hospitalier de Strasbourg, Strasbourg, France.
Laurent
L
Monassier
INSERM UMR-S 839, Université Pierre et Marie Curie, 75005 Paris, France - Institut du Fer à Moulin, 17 rue du Fer à Moulin, 75005 Paris, France.
Luc
L
Maroteaux
D000818:Animals; D001853:Bone Marrow / Q000502:physiology*; D001854:Bone Marrow Cells / Q000502:physiology; D052006:Bone Morphogenetic Protein Receptors, Type II / Q000502:physiology; D042783:Endothelial Cells / Q000502:physiology*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology*; D051379:Mice; D012701:Serotonin / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology*
D012701:Serotonin; C498218:BMPR2 protein, human; D052006:Bone Morphogenetic Protein Receptors, Type II