VEGF-A and VEGFR1 SNPs associate with preeclampsia in a Philippine population.
The vascular endothelial growth factor (VEGF) family is important for establishing normal pregnancy, and related single nucleotide polymorphisms (SNPs) are implicated in abnormal placentation and preeclampsia. We evaluated the association between preeclampsia and several VEGF SNPs among Filipinos, an ethnically distinct group with high prevalence of preeclampsia. The genotypes and allelic variants were determined in a case-control study (191 controls and 165 preeclampsia patients) through SNP analysis of VEGF-A (rs2010963, rs3025039) and VEGF-C (rs7664413) and their corresponding receptors VEGFR1 (rs722503, rs12584067, rs7335588) and VEGFR3 (rs307826) from venous blood DNA. VEGF-A rs3025039 C allele has been shown to associate with preeclampsia (odds ratio of 1.648 (1.03-2.62)), while the T allele bestowed an additive effect for the maintenance of normal, uncomplicated pregnancy and against the development of preeclampsia (odds ratio of 0.62 (0.39-0.98)). VEGFR1 rs722503 is associated with preeclampsia occurring at or after the age of 40 years. The results showed that genetic variability of VEGF-A and VEGFR1 are important in the etiology of preeclampsia among Filipinos.
a National Institute of Molecular Biology and Biotechnology, National Science Complex, College of Science, University of the Philippines , Diliman , Quezon City , Philippines.|b Department of Obstetrics and Gynecology , Philippine General Hospital - University of the Philippines , Manila , Philippines.
Melissa D
MD
Amosco
c Division of Nephrology, Department of Medicine , University of Maryland School of Medicine , Baltimore , Maryland , USA.|d Division of Renal Diseases and Hypertension, Department of Medicine , The George Washington University School of Medicine and Health Sciences , Washington , DC , USA.
Van Anthony M
VA
Villar
a National Institute of Molecular Biology and Biotechnology, National Science Complex, College of Science, University of the Philippines , Diliman , Quezon City , Philippines.
Justin Michael A
JM
Naniong
b Department of Obstetrics and Gynecology , Philippine General Hospital - University of the Philippines , Manila , Philippines.
Lara Marie G
LM
David-Bustamante
c Division of Nephrology, Department of Medicine , University of Maryland School of Medicine , Baltimore , Maryland , USA.|d Division of Renal Diseases and Hypertension, Department of Medicine , The George Washington University School of Medicine and Health Sciences , Washington , DC , USA.|e Department of Physiology , University of Maryland School of Medicine , Baltimore , Maryland , USA.|f Department of Physiology , The George Washington University School of Medicine and Health Sciences , Washington , DC , USA.
Pedro A
PA
Jose
a National Institute of Molecular Biology and Biotechnology, National Science Complex, College of Science, University of the Philippines , Diliman , Quezon City , Philippines.
Cynthia P
CP
Palmes-Saloma
D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D010679:Philippines / Q000208:ethnology; D010929:Placentation / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000453:epidemiology / Q000235:genetics; D011247:Pregnancy; D042461:Vascular Endothelial Growth Factor A / Q000097:blood / Q000235:genetics*; D042582:Vascular Endothelial Growth Factor C / Q000235:genetics*; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000235:genetics*; D040321:Vascular Endothelial Growth Factor Receptor-3 / Q000235:genetics*
C467484:VEGFA protein, human; C467486:VEGFC protein, human; D042461:Vascular Endothelial Growth Factor A; D042582:Vascular Endothelial Growth Factor C; D040281:Vascular Endothelial Growth Factor Receptor-1; D040321:Vascular Endothelial Growth Factor Receptor-3
Association study; VEGF; preeclampsia; single nucleotide polymorphism
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