Terminamines K-S, Antimetastatic Pregnane Alkaloids from the Whole Herb of Pachysandra terminalis.
Nine new pregnane alkaloids (1-9), together with eight known alkaloids (10-17), were isolated from the whole herb ofPachysandra terminalis. Their structures were elucidated on the basis of spectroscopic analyses. In addition, the isolates were examined for their ability to inhibit the migration of MDA-MB-231 cells induced by the chemokine epidermal growth factor (EGF). Alkaloids1,5,7,9,12, and17presented significant anti-metastasis activities compared with the positive reagent, LY294002.
Tianjin Key Laboratory on Technologies Enabling Development Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China. lovelxybeibei@163.com.
Xiang-Yu
XY
Li
Tianjin Key Laboratory on Technologies Enabling Development Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China. yuyang@tmu.edu.cn.
Yang
Y
Yu
Tianjin Key Laboratory on Technologies Enabling Development Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China. ijiamiao4ev@126.com.
Miao
M
Jia
Tianjin Key Laboratory on Technologies Enabling Development Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China. jinmeina@tmu.edu.cn.
Mei-Na
MN
Jin
Tianjin Key Laboratory on Technologies Enabling Development Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China. nanqin.qn@163.com.
Nan
N
Qin
Tianjin Key Laboratory on Technologies Enabling Development Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China. zhaochuan@tmu.edu.cn.
Chuan
C
Zhao
Tianjin Key Laboratory on Technologies Enabling Development Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China. duanhq@tmu.edu.cn.
Hong-Quan
HQ
Duan
Buxaceae; Pachysandra terminalis; anti-metastatic activity; pregnane alkaloids; structure-activity relationships
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