Lipidomics: Techniques, Applications, and Outcomes Related to Biomedical Sciences.
Lipidomics is a newly emerged discipline that studies cellular lipids on a large scale based on analytical chemistry principles and technological tools, particularly mass spectrometry. Recently, techniques have greatly advanced and novel applications of lipidomics in the biomedical sciences have emerged. This review provides a timely update on these aspects. After briefly introducing the lipidomics discipline, we compare mass spectrometry-based techniques for analysis of lipids and summarize very recent applications of lipidomics in health and disease. Finally, we discuss the status of the field, future directions, and advantages and limitations of the field.
Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Kui
K
Yang
Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida 32827, USA; College of Basic Medical Sciences, Zhejiang Chinese Medical University, 548 Bingwen Road, Hangzhou, Zhejiang 310053, China. Electronic address: xhan@sbpdiscovery.org.
Xianlin
X
Han
D035843:Biomedical Research / Q000295:instrumentation / Q000379:methods*; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000378:metabolism; D002853:Chromatography, Liquid / Q000379:methods; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000737:chemistry*; D059625:Liquid-Liquid Extraction / Q000379:methods*; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods*; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000378:metabolism; D009369:Neoplasms / Q000175:diagnosis / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000175:diagnosis / Q000378:metabolism; D009765:Obesity / Q000175:diagnosis / Q000378:metabolism; D012997:Solvents / Q000737:chemistry
D008055:Lipids; D012997:Solvents
biomedical science; lipid metabolism; lipidome; lipidomics; mass spectrometry; shotgun lipidomics
Mass Spectrom Rev. 2016 Jan 15;:null
26773411
Ann Am Thorac Soc. 2013 Dec;10 Suppl:S197-205
24313773
Metabolites. 2011 Dec 1;1(1):21-40
22905337
Biochim Biophys Acta. 2011 Nov;1811(11):763-75
21851861
World J Biol Psychiatry. 2016 Jan 26;:1-15
26555297
Scand J Immunol. 2015 Sep;82(3):244-53
26119046
Prostaglandins Leukot Essent Fatty Acids. 2015 Mar;94:49-54
25481335
Sci Rep. 2016 Feb 11;6:20984
26865432
Arch Biochem Biophys. 2016 Jan 1;589:27-37
26072113
Biochemistry. 2007 May 29;46(21):6417-28
17487985
J Chromatogr A. 2014 Nov 3;1372C:110-119
25465009
Mol Membr Biol. 2015;32(3):55-64
26212444
Talanta. 2016 Apr 1;150:88-96
26838385
Biochim Biophys Acta. 2016 Jan;1861(1):60-7
26515252
Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2723-32
21903946
Chem Biol Interact. 2014 Sep 5;220:181-92
25014415
Neurosci Biobehav Rev. 2013 Sep;37(8):1611-21
23800745
J Am Soc Mass Spectrom. 2015 Jan;26(1):133-48
25391725
Methods. 2005 Jun;36(2):207-24
15894491
Atherosclerosis. 2013 Jun;228(2):380-5
23623011
J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Sep 1;1000:14-21
26207874
J Lipid Res. 2013 Oct;54(10):2898-908
23868910
Annu Rev Biochem. 2014;83:45-9
24606141
Exp Eye Res. 2013 Dec;117:4-27
23769846
J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Sep 15;877(26):2664-72
19286428
Curr Atheroscler Rep. 2013 Jun;15(6):328
23605288
Pharmacol Ther. 2014 Jul;143(1):12-23
24509229
Biochimie. 2016 Jan;120:81-6
26141129
Anal Chem. 2014 Jan 7;86(1):161-75
24215393
Expert Opin Drug Discov. 2012 Jan;7(1):63-72
22468894
Proteomics Clin Appl. 2015 Feb;9(1-2):169-86
25488355
J Chromatogr A. 2014 Jun 13;1346:49-56
24794940
Cancer Treat Rev. 2004 Apr;30(2):193-204
15023437
Vasc Health Risk Manag. 2015 Jun 12;11:333-42
26109865
PLoS One. 2011;6(7):e21643
21779331
Methods Mol Biol. 2014;1175:19-34
25150864
Mol Nutr Food Res. 2013 Aug;57(8):1319-35
23818328
Mol Biosyst. 2015 Mar;11(3):698-713
25598407
Obesity (Silver Spring). 2013 Dec;21(12):E649-59
23640727
Lancet Diabetes Endocrinol. 2014 Oct;2(10):810-8
25107467
Anal Bioanal Chem. 2015 Jul;407(17):4973-93
25855150
Anal Biochem. 2013 Dec 1;443(1):88-96
23994565
Nutr Hosp. 2015 Feb 26;31 Suppl 3:177-88
25719785
J Lipid Res. 2010 Nov;51(11):3299-305
20671299
J Lipid Res. 2014 Feb;55(2):299-306
24287121
Bioanalysis. 2016 Feb;8(4):351-64
26856187
Adv Biol Regul. 2014 Jan;54:93-8
24332194
BMC Syst Biol. 2007 Feb 15;1:12
17408502
Diabetologia. 2012 Apr;55(4):1156-66
22252473
PLoS One. 2013 Oct 08;8(10):e76577
24116121
Methods Mol Biol. 2014;1198:203-20
25270931
J Sep Sci. 2010 Sep;33(17-18):2776-83
20730840
Expert Rev Proteomics. 2016 May;13(5):451-6
27121756
Chin J Nat Med. 2015 Jan;13(1):3-21
25660284
Nat Rev Immunol. 2015 Aug;15(8):511-23
26139350
Curr Eye Res. 2013 Apr;38(4):417-27
23330842
Eur J Lipid Sci Technol. 2009;111(1):39-52
19690629
Expert Opin Drug Discov. 2014 Jul;9(7):819-36
24819582
J Inherit Metab Dis. 2015 Jan;38(1):41-52
25409862
Neural Plast. 2016;2016:2426398
26839710
Nat Rev Endocrinol. 2016 Nov;12 (11):668-679
27469345
Wiley Interdiscip Rev Syst Biol Med. 2013 Jan-Feb;5(1):11-35
23059966
FEBS J. 2012 Aug;279(15):2610-23
22621751
Prostaglandins Leukot Essent Fatty Acids. 2013 Feb;88(2):149-54
23313470
Chem Biol. 2015 Mar 19;22(3):412-25
25794437
Trends Analyt Chem. 2014 Oct 1;61:192-206
25309011
Anal Bioanal Chem. 2015 Jul;407(17):4995-5007
25893801
Mass Spectrom Rev. 2012 Jan-Feb;31(1):134-78
21755525
Mol Cancer Res. 2014 Nov;12(11):1677-88
25063587
J Biol Chem. 2010 Dec 17;285(51):39976-85
20923771
Anal Chem. 2009 Jun 1;81(11):4356-68
19408941
Pharmacol Ther. 2016 Jan;157:28-42
26546991
Prog Lipid Res. 2014 Apr;54:14-31
24462586
Curr Alzheimer Res. 2005 Jan;2(1):65-77
15977990
Arch Biochem Biophys. 2016 Jan 1;589:131-7
26314918
Anal Bioanal Chem. 2015 Jul;407(17):5065-77
25651902
Oncotarget. 2016 Mar 15;7(11):12582-97
26862848
J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Sep 15;877(26):2716-21
19395321
Int J Mol Sci. 2016 May 25;17 (6):
27231903
FEBS J. 2013 Jun;280(12):2817-29
23432956
Diabetes. 2013 Feb;62(2):639-48
23043162
Clin Sci (Lond). 2013 Mar;124(5):289-306
23157406
Drug Discov Today Technol. 2015 Jun;13:33-8
26190681
Circ Cardiovasc Genet. 2014 Dec;7(6):941-54
25516624
Biochim Biophys Acta. 2011 Nov;1811(11):925-34
21767661
J Lipid Res. 2011 Dec;52(12):2314-22
21960706
J Clin Biochem Nutr. 2014 Sep;55(2):79-84
25320453
Curr Eye Res. 2013 Oct;38(10):995-1005
23981028
J Sep Sci. 2016 Jan;39(1):38-50
26394722
Eur J Nutr. 2015 Mar;54(2):173-81
24740590
Cardiovasc Drugs Ther. 2016 Feb;30(1):19-32
26896184
Oncotarget. 2016 Jun 14;7(24):36622-36631
27153558
Annu Rev Anal Chem (Palo Alto Calif). 2010;3:433-65
20636050
J Alzheimers Dis. 2015 ;48(2):537-46
26402017
Anal Chem. 2014 Mar 4;86(5):2703-10
24471557
Neuropsychopharmacology. 2014 Jan;39(1):24-33
23842599
J Lipid Res. 2013 Apr;54(4):1023-32
23365150
Brief Bioinform. 2015 Jan;16(1):104-17
24273217
Nat Methods. 2011 Apr;8(4 Suppl):S20-9
21451513
Circ Cardiovasc Genet. 2016 Jun;9(3):291-313
27095829
Mol Nutr Food Res. 2013 Aug;57(8):1306-18
23413227
Curr Org Chem. 2013 Dec;17(23):2891-2905
24376367
Arch Biochem Biophys. 2016 Jan 1;589:120-30
26116790
Circ Cardiovasc Genet. 2011 Jun;4(3):232-42
21511877
J Clin Med. 2015 Sep 07;4(9):1753-60
26371049
Methods Enzymol. 2007;433:1-25
17954226
Rapid Commun Mass Spectrom. 2014 Oct 30;28(20):2201-10
25178724
Anal Chem. 2014 Oct 7;86(19):9662-9
25160652
PLoS One. 2013 Sep 27;8(9):e74341
24086336
Mol Nutr Food Res. 2013 Aug;57(8):1390-400
23417926
Annu Rev Biochem. 2014;83:79-98
24606142
Prog Retin Eye Res. 2012 Nov;31(6):527-50
22732126
Anal Chim Acta. 2015 Jul 23;885:1-16
26231889
Front Nutr. 2016 Jan 27;3:3
26858949
Curr Atheroscler Rep. 2014 Nov;16(11):455
25236775
J Lipid Res. 2009 Apr;50 Suppl:S317-22
19050313
Biochim Biophys Acta. 2016 Sep;1861(9 Pt B):1329-35
27086144
J Mol Endocrinol. 2009 Mar;42(3):185-90
19060177
J Lipid Res. 2013 Nov;54(11):2950-63
23543772
J Am Soc Mass Spectrom. 2016 Feb;27(2):255-64
26466600
Anal Biochem. 2007 Dec 15;371(2):135-45
17920553
PLoS One. 2013;8(2):e55859
23409068
Gene. 2015 Jan 10;554(2):131-9
25445283
Prog Lipid Res. 2016 Jan;61:83-108
26703190
Drug Discov Today. 2014 Feb;19(2):164-70
24055840
Eur Heart J. 2015 Oct 14;36(39):2635-42
26049157
Antioxid Redox Signal. 2015 Jun 20;22(18):1646-66
25694038
World J Biol Chem. 2013 Nov 26;4(4):102-10
24340133
J Pharm Biomed Anal. 2015 Sep 10;113:151-62
25769667
Trends Mol Med. 2015 Dec;21(12):736-48
26596867
Biochim Biophys Acta. 2015 Apr;1851(4):456-68
25486530
J Huntingtons Dis. 2015 ;4(2):187-201
26397899
Transl Psychiatry. 2015 Jan 13;5:e494
25585166
EXS. 2012;101:471-98
22945580
Biochim Biophys Acta. 2011 Nov;1811(11):748-57
21683157
J Lipid Res. 2010 Aug;51(8):2153-70
20410019
Acta Neuropsychiatr. 2015 Oct;27(5):270-8
25858158
Mass Spectrom Rev. 2014 Nov-Dec;33(6):471-500
24288070
Prog Lipid Res. 2014 Jul;55:43-60
24995945
Am J Clin Nutr. 2014 Jan;99(1):46-53
24153346
Pediatr Diabetes. 2016 Feb;17 (1):3-14
26420304
Int Rev Cell Mol Biol. 2014;313:1-26
25376488