Calcium phosphate: a substitute for aluminum adjuvants?
Calcium phosphate was used as an adjuvant in France in diphtheria, tetanus, pertussis and poliomyelitis vaccines. It was later completely substituted by alum salts in the late 80's, but it still remains as an approved adjuvant for the World Health Organization for human vaccination. Area covered: Thus, calcium phosphate is now considered as one of the substances that could replace alum salts in vaccines. The aim of this paper is to draw a review of existing data on calcium phosphate as an adjuvant in order to bring out the strengths and weaknesses for its use on a large scale. Expert commentary: Calcium phosphate is a compound naturally present in the organism, safe and already used in human vaccination. Beyond comparisons with the other adjuvants, calcium phosphate represents a good candidate to replace or to complete alum salts as a vaccine adjuvant.
a Association E3M (Entraide aux Malades de Myofasciite à Macrophages) , Monprimblanc , France.
Jean-Daniel
JD
Masson
b Pharmacien « Service des Allergènes » , de l'Institut Pasteur , Paris , France.
Michel
M
Thibaudon
c Laboratoire de Microbiologie, hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, & Faculté de Médecine Paris Descartes , Université Paris Descartes, Sorbonne Paris Cité , Paris , France.
Laurent
L
Bélec
d École nationale vétérinaire d'Alfort , Maisons-Alfort , France.|e Inserm U955 E10 , Université Paris Est Créteil , Créteil , France.
Guillemette
G
Crépeaux
D000276:Adjuvants, Immunologic / Q000009:adverse effects / Q000494:pharmacology*; D000534:Alum Compounds / Q000737:chemistry / Q000494:pharmacology; D000535:Aluminum / Q000494:pharmacology*; D000818:Animals; D002130:Calcium Phosphates / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000737:chemistry / Q000276:immunology / Q000494:pharmacology; D006801:Humans
D000276:Adjuvants, Immunologic; D000534:Alum Compounds; D002130:Calcium Phosphates; D015721:Diphtheria-Tetanus-Pertussis Vaccine; C041524:aluminum sulfate; D000535:Aluminum
Vaccine; adjuvant; aluminum salts; calcium phosphate; immune response; safety