The role of hydrogen sulfide in aging and age-related pathologies.
When humans grow older, they experience inevitable and progressive loss of physiological function, ultimately leading to death. Research on aging largely focuses on the identification of mechanisms involved in the aging process. Several proposed aging theories were recently combined as the 'hallmarks of aging'. These hallmarks describe (patho-)physiological processes that together, when disrupted, determine the aging phenotype. Sustaining evidence shows a potential role for hydrogen sulfide (H2S) in the regulation of aging. Nowadays, H2S is acknowledged as an endogenously produced signaling molecule with various (patho-) physiological effects. H2S is involved in several diseases including pathologies related to aging. In this review, the known, assumed and hypothetical effects of hydrogen sulfide on the aging process will be discussed by reviewing its actions on the hallmarks of aging and on several age-related pathologies.
Department of Pathology and Medical Biology, University Medical Center Groningen, the Netherlands.
Bernard W
BW
Perridon
Department of Surgery, University Medical Center Groningen, the Netherlands.
Henri G D
HG
Leuvenink
Department of Pathology and Medical Biology, University Medical Center Groningen, the Netherlands.
Jan-Luuk
JL
Hillebrands
Department of Pathology and Medical Biology, University Medical Center Groningen, the Netherlands.
Harry
H
van Goor
Department of Pathology and Medical Biology, University Medical Center Groningen, the Netherlands.|Department of Neurosurgery, Erasmus Medical Center Rotterdam, the Netherlands.
Eelke M
EM
Bos
D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D044127:Epigenesis, Genetic; D042822:Genomic Instability; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D006862:Hydrogen Sulfide
H2S; aging; gasotransmitters; hallmarks of aging; hydrogen sulfide
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