Filamentation protectsCandida albicansfrom amphotericin B-induced programmed cell death via a mechanism involving the yeast metacaspase,MCA1.
The budding yeastCandida albicansis one of the most significant fungal pathogens worldwide. It proliferates in two distinct cell types: blastopores and filaments. Only cells that are able to transform from one cell type into the other are virulent in mouse disease models. Programmed cell death is a controlled form of cell suicide that occurs whenC. albicanscells are exposed to fungicidal drugs like amphotericin B and caspofungin, and to other stressful conditions. We now provide evidence that suggests that programmed cell death is cell-type specific in yeast: FilamentousC. albicanscells are more resistant to amphotericin B- and caspofungin-induced programmed cell death than their blastospore counterparts. Finally, our genetic data suggests that this phenomenon is mediated by a protective mechanism involving the yeast metacaspase,MCA1.
Department of Biology, Providence College, 1 Cunningham Square, Providence, Rhode Island 02918, U.S.A.
David J
DJ
Laprade
Department of Biology, Providence College, 1 Cunningham Square, Providence, Rhode Island 02918, U.S.A.
Melissa S
MS
Brown
Department of Biology, Providence College, 1 Cunningham Square, Providence, Rhode Island 02918, U.S.A.
Morgan L
ML
McCarthy
Department of Biology, Providence College, 1 Cunningham Square, Providence, Rhode Island 02918, U.S.A.
James J
JJ
Ritch
Department of Biology, Providence College, 1 Cunningham Square, Providence, Rhode Island 02918, U.S.A.
Nicanor
N
Austriaco
Candida albicans; MCA1; amphotericin B; caspofungin; filamentation; programmed cell death
Appl Environ Microbiol. 2001 Jul;67(7):2982-92
11425711
Cell Death Differ. 2002 Apr;9(4):367-93
11965491
FEMS Immunol Med Microbiol. 2002 Oct 11;34(2):153-7
12381467
Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14327-32
14623979
Infect Immun. 2004 Apr;72(4):2386-9
15039365
Mol Biol Cell. 2005 Jun;16(6):2903-12
15814840
Mol Biol Cell. 2006 Jan;17(1):295-307
16267276
Eukaryot Cell. 2007 Oct;6(10):1736-44
17766464
Biochim Biophys Acta. 2008 Jul;1783(7):1436-48
18252203
Biochim Biophys Acta. 2008 Jul;1783(7):1369-80
18294459
Biochim Biophys Acta. 2008 Jul;1783(7):1320-7
18355456
Biochim Biophys Acta. 2008 Jul;1783(7):1311-9
18358844
Fungal Genet Biol. 2009 Feb;46(2):183-9
19049890
Biochem Biophys Res Commun. 2009 May 1;382(2):227-31
19250922
Antimicrob Agents Chemother. 2009 Aug;53(8):3347-52
19364856
Antimicrob Agents Chemother. 2009 Jun;53(6):2392-401
19364863
Int J Antimicrob Agents. 2009 Oct;34(4):333-9
19376687
FEBS Lett. 2009 Aug 6;583(15):2513-6
19596007
Eukaryot Cell. 2009 Nov;8(11):1750-8
19666778
Drugs. 2009;69 Suppl 1:15-20
19877729
J Hosp Infect. 2010 Feb;74(2):189-91
20061059
Cell Death Differ. 2010 May;17(5):763-73
20075938
Microbes Infect. 2010 Jun;12(6):488-96
20223293
PLoS One. 2010 Mar 29;5(3):e9929
20360952
Nat Genet. 2010 Jul;42(7):590-8
20543849
Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13348-53
20624963
Expert Rev Anti Infect Ther. 2011 Mar;9(3):317-24
21417871
FEMS Yeast Res. 2011 Aug;11(5):389-97
21439008
Biochem Soc Trans. 2011 Oct;39(5):1502-8
21936842
FEMS Yeast Res. 2012 Mar;12(2):249-65
22188402
Am J Med. 2012 Jan;125(1 Suppl):S3-13
22196207
AIDS. 2012 Jul 31;26(12):1457-72
22472853
FEMS Microbiol Lett. 2012 Aug;333(2):85-93
22540673
J Biol Chem. 2012 Aug 24;287(35):29251-9
22761449
Diagn Microbiol Infect Dis. 2012 Dec;74(4):323-31
23102556
Antimicrob Agents Chemother. 2013 Jan;57(1):326-32
23114781
Expert Rev Clin Immunol. 2012 Nov;8(8):755-65
23167687
J Proteomics. 2013 Apr 9;81:24-30
23376483
Cold Spring Harb Perspect Biol. 2013 Mar 01;5(3):a008649
23457257
FEMS Yeast Res. 2014 Feb;14(1):119-35
24205865
Clin Microbiol Infect. 2014 Jun;20 Suppl 6:5-10
24506442
Science. 2014 Jun 20;344(6190):1389-92
24855027
Mol Cell Proteomics. 2015 Jan;14(1):93-108
25348831
Semin Cell Dev Biol. 2015 Mar;39:3-11
25725369
Nat Commun. 2015 Mar 31;6:6741
25824284
Genetics. 2015 Aug;200(4):1003-14
26272996
Microb Cell. 2014 Jan 15;1(2):58-63
28357223
Br J Cancer. 1972 Aug;26(4):239-57
4561027
Sabouraudia. 1975 Jul;13(2):148-53
808868
Genetics. 1993 Jul;134(3):717-28
8349105
Cell. 1997 Sep 5;90(5):939-49
9298905