[Purple drank: A dangerous cocktail].
"Purple drank" is a dangerous hallucinogenic cocktail commonly used by teenagers, made popular by American rappers and social networks. It combines codeine-based cough syrup, antihistamines such as promethazine, and soda. Unknown by caregivers, it may be responsible for serious neuropsychological complications. We report the effects of this new risky behavior in three patients: a 14-year-old girl and her boyfriend, both found in an initial state of drowsiness, followed by hallucinations and anticholinergic toxidrome; and another teenager whose chronic use led to addiction with increasing doses. It is important to identify signs of such intoxication and to inform patients about the risks of respiratory depression, drowsiness, and delirium linked to acute medication misuse.
Pédiatrie générale et urgences pédiatriques, CHU Ambroise Paré, AP-HP, 9, avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France.
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Garcin
Pédiatrie générale et urgences pédiatriques, CHU Ambroise Paré, AP-HP, 9, avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France; UFR des sciences de la santé Simone Veil, université de Versailles-St-Quentin, 2, avenue de la Source-de-la-Bièvre, 78180 Montigny-le-Bretonneux, France.
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Le Roch
Urgences adultes, CHU Ambroise-Paré, AP-HP, 9, avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France.
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Agbessi
Pédiatrie générale et urgences pédiatriques, CHU Ambroise Paré, AP-HP, 9, avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France.
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Lobut
Pharmacie, CHU Ambroise-Paré, AP-HP, 9, avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France.
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Lecoeur
Pédiatrie générale et urgences pédiatriques, CHU Ambroise Paré, AP-HP, 9, avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France. Electronic address: gregoire.benoist@aphp.fr.
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Benoist
D000293:Adolescent; D064807:Anticholinergic Syndrome / Q000209:etiology; D000996:Antitussive Agents / Q000009:adverse effects*; D001628:Beverages / Q000009:adverse effects*; D003061:Codeine / Q000009:adverse effects*; D005260:Female; D006212:Hallucinations / Q000139:chemically induced; D006633:Histamine Antagonists / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009293:Opioid-Related Disorders / Q000150:complications*
D000996:Antitussive Agents; D006633:Histamine Antagonists; D003061:Codeine