Bovine tooth is a substitute for human tooth on bond strength studies: A systematic review and meta-analysis of in vitro studies.
This study aimed to systematically review the literature to compare the bond strength values achieved from human and bovine teeth of in vitro studies.



The PubMed/MEDLINE, ISI Web of Science and Scopus electronic databases were searched to select laboratorial studies that evaluated adhesive systems bond strength to human and bovine teeth. No publication year or language restriction was considered.



From 1,285 potentially eligible studies, 15 were selected for full-text analysis, 11 were included in the systematic review and 9 in the meta-analysis. Two authors independently selected the studies, extracted the data and assessed the risk of bias. Mean differences were obtained by comparing bond strength values between human and bovine teeth (overall analysis), and considering enamel and dentin separately (subgroups analysis). Statistical analysis was performed using RevMan5.1, with random effects model, at a significance level of p=0.05.



No significant difference was found between human and bovine teeth (p=0.35), either for enamel (p=0.07) or for dentin (p=0.93) substrates. Low to moderate heterogeneity was found on the meta-analysis. All included studies in the systematic review scored between medium and high risk of bias.



Bovine teeth can be a reliable substitute for human ones on bond strength studies of adhesive systems to both enamel and dentin substrates.
Department of Restorative Dentistry, Federal University of Santa Maria, Rua Marechal Floriano Peixoto, 1184, 97015-270 Santa Maria, RS, Brazil. Electronic address: fzovico@hotmail.com.
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Soares
Graduate Program in Dental Science, Federal University of Santa Maria, Rua Marechal Floriano Peixoto, 1184, 97015-270 Santa Maria, RS, Brazil. Electronic address: andressafollak@gmail.com.
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Follak
School of Dentistry, Federal University of Santa Maria, Rua Marechal Floriano Peixoto, 1184, 97015-270 Santa Maria, RS, Brazil. Electronic address: lucas.saldanha.da.rosa@gmail.com.
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da Rosa
Graduate Program in Dental Science, Federal University of Santa Maria, Rua Marechal Floriano Peixoto, 1184, 97015-270 Santa Maria, RS, Brazil. Electronic address: animontag@gmail.com.
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Montagner
Graduate Program in Dental Science, Federal University of Santa Maria, Rua Marechal Floriano Peixoto, 1184, 97015-270 Santa Maria, RS, Brazil. Electronic address: tathilenzi@hotmail.com.
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Lenzi
Department of Stomatology, Federal University of Santa Maria, Rua Marechal Floriano Peixoto, 1184, 97015-270 Santa Maria, RS, Brazil. Electronic address: rachelrocha@smail.ufsm.br.
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Rocha
D000818:Animals; D002417:Cattle; D001840:Dental Bonding; D003743:Dental Enamel; D003804:Dentin; D017220:Dentin-Bonding Agents; D006801:Humans; D008422:Materials Testing; D019279:Resin Cements; D014070:Tooth
D017220:Dentin-Bonding Agents; D019279:Resin Cements
Bond strength; Bovine teeth; Human teeth; Substrate