Adeno-Associated Virus Serotype 9-Expressed ZMapp in Mice Confers Protection Against Systemic and Airway-Acquired Ebola Virus Infection.
Adeno-associated viral vectors can be used as a platform for delivering biological countermeasures against pandemic and biological threats. We show that vector delivery of two antibody components of the ZMapp product is effective in mice against systemic and airway challenge with a mouse-adapted strain of Ebola virus. This platform provides a generic manufacturing solution and overcomes some of the delivery challenges associated with repeated administration of the protective protein.
Gene Therapy Program.|Department of Pathology and Laboratory Medicine.
Maria P
MP
Limberis
Gene Therapy Program.|Department of Medicine, University of Pennsylvania, Philadelphia.
Anna
A
Tretiakova
Gene Therapy Program.|Department of Medicine, University of Pennsylvania, Philadelphia.
Kalyani
K
Nambiar
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada.|Department of Medical Microbiology, University of Manitoba, Canada.
Gary
G
Wong
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada.|Department of Medical Microbiology, University of Manitoba, Canada.
Trina
T
Racine
Gene Therapy Program.|Department of Medicine, University of Pennsylvania, Philadelphia.
Marco
M
Crosariol
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada.|Department of Medical Microbiology, University of Manitoba, Canada.
Qiu
Q
Xiangguo
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada.|Department of Medical Microbiology, University of Manitoba, Canada.
Gary
G
Kobinger
Gene Therapy Program.|Department of Medicine, University of Pennsylvania, Philadelphia.
James M
JM
Wilson
D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis* / Q000235:genetics; D000229:Dependovirus / Q000235:genetics*; D004195:Disease Models, Animal; D004337:Drug Carriers; D005260:Female; D015870:Gene Expression; D015316:Genetic Therapy / Q000379:methods; D019142:Hemorrhagic Fever, Ebola / Q000276:immunology / Q000517:prevention & control*; D007155:Immunologic Factors / Q000096:biosynthesis* / Q000235:genetics; D008807:Mice, Inbred BALB C; D014161:Transduction, Genetic; D016896:Treatment Outcome
D000911:Antibodies, Monoclonal; D004337:Drug Carriers; D007155:Immunologic Factors; C000594176:ZMapp
airway; animals; infectious disease; prophylaxis; protection; vaccine; vector; virus