Searching for better animal models of BPD: a perspective.
There have been many efforts to develop good animal models of bronchopulmonary dysplasia (BPD) to better understand the pathophysiology and mechanisms underlying development of BPD as well as to test potential strategies for its prevention and treatment. This Perspectives summarizes the features of common animal models of BPD and the strengths and limitations of such models. Potential optimal approaches to development of animal models are indicated, with the underlying concepts that require emphasis.
Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama; and ambal@uab.edu.
Namasivayam
N
Ambalavanan
Department of Lung Development and Remodelling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Rory E
RE
Morty
D000818:Animals; D001997:Bronchopulmonary Dysplasia / Q000473:pathology* / Q000628:therapy; D004195:Disease Models, Animal; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000196:embryology / Q000473:pathology
animal models; bronchopulmonary dysplasia; diseases; infant; lung development; lung injury; premature
Am J Physiol Lung Cell Mol Physiol. 2015 Oct 1;309(7):L710-24
26232299
Am J Physiol Lung Cell Mol Physiol. 2013 Aug 1;305(3):L205-21
23709622
Am J Respir Crit Care Med. 2011 Jun 15;183(12):1715-22
21471086
N Engl J Med. 1967 Feb 16;276(7):357-68
5334613
Am J Physiol Lung Cell Mol Physiol. 2014 Dec 15;307(12):L970-7
25281639
Am J Physiol Lung Cell Mol Physiol. 2014 Dec 15;307(12):L959-69
25326582
Am J Respir Crit Care Med. 2010 Feb 15;181(4):394-418
20130146
Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15;308(2):L118-29
25398985
Am J Respir Crit Care Med. 2015 Sep 1;192(5):589-96
26030808
Exp Lung Res. 2002 Sep;28(6):457-71
12217212
Am J Physiol Lung Cell Mol Physiol. 2014 Dec 15;307(12):L948-58
25305248
Semin Perinatol. 2006 Aug;30(4):227-32
16860163
J Pediatr. 2014 Jan;164(1):40-45.e4
24055328
J Endocrinol. 1969 Dec;45(4):515-23
5366112
Science. 2008 Sep 26;321(5897):1837-41
18818360
Am J Physiol Lung Cell Mol Physiol. 2014 Dec 15;307(12):L936-47
25305249
Pediatrics. 2010 Sep;126(3):443-56
20732945
Clin Chim Acta. 2015 Dec 7;451(Pt A):39-45
25578394
Tohoku J Exp Med. 1964 Dec 25;84:250-5
14242750
Am J Respir Crit Care Med. 2015 Jul 15;192(2):134-56
26038806
J Pediatr. 2015 Mar;166(3):531-7.e13
25449221
Am J Physiol Lung Cell Mol Physiol. 2015 May 15;308(10):L983-L1001
25770179
Pediatrics. 2006 Jun;117(6):1901-6
16740829
Am J Physiol Lung Cell Mol Physiol. 2015 Dec 1;309(11):L1239-72
26361876
Am J Physiol Lung Cell Mol Physiol. 2014 Feb 15;306(4):L341-50
24375800
Pediatrics. 2008 Sep;122(3):479-85
18762515
Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15686-91
23986498
Semin Perinatol. 2015 Dec;39(8):584-91
26471063
J Genet Genomics. 2013 Feb 20;40(2):67-73
23439405
Am J Physiol Lung Cell Mol Physiol. 2013 Jul 1;305(1):L15-22
23624789
Nat Biotechnol. 2014 Apr;32(4):347-55
24584096
Clin Perinatol. 2015 Dec;42(4):739-54
26593076
Pediatr Res. 1978 Aug;12(8):841-8
581094
Am J Physiol Lung Cell Mol Physiol. 2014 Feb;306(3):L246-59
24285264
Neurobiol Dis. 2013 Feb;50:69-75
23064437
Am J Physiol Lung Cell Mol Physiol. 2015 Jun 1;308(11):L1145-58
25840994
Am J Respir Crit Care Med. 2001 Jun;163(7):1723-9
11401896
Pediatr Pulmonol. 1991;10(3):157-63
1852512