The Response of C19 Δ5-steroids to ACTH Stimulation and Hypoglycemia in Insulin Tolerance Test for Adrenal Insufficiency.
Studies on the time course of ACTH- or insulin-induced hypoglycemia stimulating adrenal androgens are usually limited to dehydroepiandrosterone and/or its sulphate. Our data on dehydroepiandrosterone (DHEA) and its hydroxylated metabolites clearly show that measurements of DHEA and its sulphate (DHEAS) are valuable markers of the integrity of the HPA (hypothalamus-pituitary-adrenal) axis. Assessments of HPA function should rely on measurements of baseline and/or stimulated serum cortisol concentrations, and C19 Δ5-steroids may provide additional information. The art of stimulation of 7- and 16-hydroxylated metabolites of DHEA can help our understanding of the formation sequence of these compounds.
Institute of Endocrinology, Prague, Czech Republic.
Michaela
M
Dušková
Institute of Endocrinology, Prague, Czech Republic.
Lucie
L
Kolátorová Sosvorová
Institute of Endocrinology, Prague, Czech Republic.
Martin
M
Hill
3rd Department of Medicine - Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.|Institute of Endocrinology, Prague, Czech Republic.
Kateřina
K
Šimůnková
Institute of Endocrinology, Prague, Czech Republic.
Hana
H
Jandíková
Institute of Endocrinology, Prague, Czech Republic.
Hana
H
Pospíšilová
Institute of Endocrinology, Prague, Czech Republic.
Monika
M
Šrámková
3rd Department of Medicine - Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.
Mikuláš
M
Kosák
3rd Department of Medicine - Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.
Michal
M
Kršek
3rd Department of Medicine - Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.
Václav
V
Hána
Institute of Endocrinology, Prague, Czech Republic. lstarka@endo.cz.
Luboslav
L
Stárka
D049913:ACTH-Secreting Pituitary Adenoma / Q000097:blood / Q000175:diagnosis*; D000309:Adrenal Insufficiency / Q000097:blood / Q000175:diagnosis*; D000328:Adult; D003687:Dehydroepiandrosterone / Q000008:administration & dosage; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D003940:Diagnostic Techniques, Endocrine; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007003:Hypoglycemia / Q000139:chemically induced; D008875:Middle Aged
D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate; D006854:Hydrocortisone
16-hydroxy-DHEA; 7-hydroxy-DHEA; ACTH test; Adrenal insufficiency; Dehydroepiandrosterone; Insulin tolerance test