Hyaluronic Acid (HA) Scaffolds and Multipotent Stromal Cells (MSCs) in Regenerative Medicine.
Traditional methods for tissue regeneration commonly used synthetic scaffolds to regenerate human tissues. However, they had several limitations, such as foreign body reactions and short time duration. In order to overcome these problems, scaffolds made of natural polymers are preferred. One of the most suitable and widely used materials to fabricate these scaffolds is hyaluronic acid. Hyaluronic acid is the primary component of the extracellular matrix of the human connective tissue. It is an ideal material for scaffolds used in tissue regeneration, thanks to its properties of biocompatibility, ease of chemical functionalization and degradability. In the last few years, especially from 2010, scientists have seen that the cell-based engineering of these natural scaffolds allows obtaining even better results in terms of tissue regeneration and the research started to grow in this direction. Multipotent stromal cells, also known as mesenchymal stem cells, plastic-adherent cells isolated from bone marrow and other mesenchymal tissues, with self-renew and multi-potency properties are ideal candidates for this aim. Normally, they are pre-seeded onto these scaffolds before their implantation in vivo. This review discusses the use of hyaluronic acid-based scaffolds together with multipotent stromal cells, as a very promising tool in regenerative medicine.
Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Str. Le Grazie 8, 37134, Verona, Italy. elena.daipre@univr.it.
Elena Dai
ED
Prè
Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Str. Le Grazie 8, 37134, Verona, Italy.
Giamaica
G
Conti
Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Str. Le Grazie 8, 37134, Verona, Italy.
Andrea
A
Sbarbati
D001672:Biocompatible Materials / Q000378:metabolism / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D006801:Humans; D006820:Hyaluronic Acid / Q000378:metabolism* / Q000494:pharmacology; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000187:drug effects; D044968:Regenerative Medicine / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds
D001672:Biocompatible Materials; D006820:Hyaluronic Acid
Hyaluronic acid; Mesenchymal stem cells; Multipotent stromal cells; Regenerative medicine; Scaffolds; Tissue engineering
Adv Drug Deliv Rev. 2015 Apr;84:222-39
25446135
J Biomed Mater Res A. 2014 Aug;102(8):2725-35
24026971
Stem Cells. 2007 Nov;25(11):2896-902
17901396
Acta Biomater. 2013 Nov;9(11):9012-26
23851171
Stem Cell Rev. 2013 Feb;9(1):32-43
22529014
Annu Rev Cell Dev Biol. 2014;30:677-704
25150008
Stem Cell Rev. 2006;2(2):155-62
17237554
ACS Appl Mater Interfaces. 2014 Nov 26;6(22):19668-79
25361388
Plast Reconstr Surg. 2007 Apr 15;119(5):1409-22; discussion 1423-4
17415234
Adv Mater. 2011 Mar 25;23(12):H41-56
21394792
Mol Biol Cell. 2002 Dec;13(12):4279-95
12475952
Exp Cell Res. 2008 Feb 1;314(3):603-15
18022619
J Biomed Mater Res A. 2009 Nov;91(2):416-27
18985778
Int J Biochem Cell Biol. 2014 Oct;55:1-10
25110036
Stem Cells. 2009 Oct;27(10):2624-35
19676124
J Biol Eng. 2014 May 01;8:10
25061479
Acta Biomater. 2014 Apr;10 (4):1571-1580
23899481
Tissue Eng Part A. 2008 Sep;14(9):1527-37
18707229
Mater Sci Eng C Mater Biol Appl. 2015;52:90-6
25953544
Cells. 2012 Nov 08;1(4):1045-60
24710542
Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9875-80
21628574
Stem Cell Res Ther. 2014 Mar 19;5(2):39
24646697
Regen Biomater. 2016 Jun;3(2):99-105
27047675
Tissue Eng Part A. 2011 Apr;17(7-8):1137-45
21142648
Biomed Res Int. 2014;2014:398069
25250319
Tissue Eng Part A. 2009 Feb;15(2):243-54
19193129
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3305-10
20133731
World J Stem Cells. 2015 May 26;7(4):728-44
26029344
Acta Biomater. 2014 Apr;10(4):1558-70
24361428
Glycoconj J. 2015 May;32(3-4):93-103
25971701
J Biomed Mater Res A. 2014 Jul;102(7):2220-9
23913820
Stem Cells Dev. 2014 Apr 1;23(7):717-28
24256547
J Mech Behav Biomed Mater. 2012 Jul;11:92-101
22658158
Stem Cell Res Ther. 2015 Dec 30;6:260
26718750
Wound Repair Regen. 2015 Jan-Feb;23(1):57-64
25421559
Carbohydr Polym. 2013 Feb 15;92(2):1262-79
23399155
J Orthop Surg Res. 2014 Mar 17;9(1):18
24628910
Cell Stem Cell. 2008 Apr 10;2(4):313-9
18397751
Biomaterials. 2014 Jan;35(4):1150-62
24215733
Int J Biol Macromol. 2016 May;86:917-28
26893053
J Surg Res. 2013 Jan;179(1):e21-9
22475350
Biotechnol Lett. 2010 Jun;32(6):733-42
20155383
Artif Organs. 2013 Jul;37(7):648-55
23495957
Cell Transplant. 2011;20(8):1193-208
21092414
Tissue Eng Part A. 2014 Jul;20(13-14):1993-2004
24517159
J Cell Physiol. 2007 Nov;213(2):341-7
17620285
Clin Cases Miner Bone Metab. 2015 May-Aug;12(2):183-7
26604947
Stem Cell Res Ther. 2015 Jul 02;6:123
26133757
Acta Biomater. 2013 Feb;9(2):5170-80
23079022
Cytotherapy. 2006;8(4):315-7
16923606
Biochem Res Int. 2012;2012:346972
22400115
J Biomed Mater Res A. 2005 Jun 1;73(3):275-83
15789422
Biochem Biophys Res Commun. 2011 Oct 14;414(1):270-6
21951845
Tissue Eng Part A. 2009 May;15(5):1041-52
19119920
Clin Orthop Relat Res. 2011 Oct;469(10):2744-53
21424832
Ann Plast Surg. 2013 Dec;71(6):664-70
23429220
Differentiation. 2013 Nov-Dec;86(4-5):171-83
24462469
Biomaterials. 2009 Aug;30(22):3757-65
19410289
Eur Cell Mater. 2010 Sep 06;20:134-48
20821371
Acta Biomater. 2012 Feb;8(2):659-66
22061106
Soft Matter. 2012;8(12):3280-3294
22419946
Life Sci. 2007 May 1;80(21):1921-43
17408700
Laryngoscope. 2014 Mar;124(3):E64-72
24115025
Biomaterials. 2016 Jan;77:44-52
26580785
Gerontology. 2013;59(1):71-6
23006468
J Cell Physiol. 2013 Aug;228(8):1762-73
23359523
Mater Sci Eng C Mater Biol Appl. 2015 Mar;48:651-62
25579968
Acta Otorhinolaryngol Ital. 2011 Apr;31(2):59-69
22058586
Cell. 2007 Oct 19;131(2):324-36
17956733
Science. 1999 Apr 2;284(5411):143-7
10102814
Biotechnol Lett. 2007 Jan;29(1):17-25
17091377
Methods. 2016 Apr 15;99:69-80
26384579
Osteoarthritis Cartilage. 2009 Dec;17(12):1639-48
19631307
Cell Tissue Res. 2015 Sep;361(3):745-53
25795142
Biomaterials. 2005 Oct;26(28):5677-86
15878373
Acta Biomater. 2012 Aug;8(8):3027-34
22546516
J R Soc Interface. 2014 Nov 6;11(100):20140817
25232055
Biomaterials. 2007 Dec;28(34):5131-6
17709136
Stem Cells Int. 2016;2016:6737345
27057174