Difference of auditory brainstem responses by stimulating to round and oval window in animal experiments.
ABSTACT To ensure the safety and efficacy of implantable hearing aids, animal experiments are an essential developmental procedure, in particular, auditory brainstem responses (ABRs) can be used to verify the objective effectiveness of implantable hearing aids. This study measured and compared the ABRs generated when applying the same vibration stimuli to an oval window and round window. The ABRs were measured using a TDT system 3 (TDT, USA), while the vibration stimuli were applied to a round window and oval window in 4 guinea pigs using a piezo-electric transducer with a proper contact tip. A paired t-test was used to determine any differences between the ABR amplitudes when applying the stimulation to an oval window and round window. The paired t-test revealed a significant difference between the ABR amplitudes generated by the round and oval window stimulation (t = 10.079, α < .0001). Therefore, the results confirmed that the biological response to round window stimulation was not the same as that to oval window stimulation.
a Department of Biomedical Engineering , School of Medicine, Kyungpook National University , Daegu , Korea.
Jyung Hyun
JH
Lee
b Graduate School of Electronics Engineering , Graduate school, Kungpook National University , Daegu , Korea.
Hyo Soon
HS
Park
c Department of Biomedical Engineering , School of Medicine, Keimyung University , Daegu , Korea.
Qun
Q
Wei
a Department of Biomedical Engineering , School of Medicine, Kyungpook National University , Daegu , Korea.
Myoung Nam
MN
Kim
d School of Electronics Engineering , College of IT Engineering, Kyungpook National University , Daegu , Korea.
Jin-Ho
JH
Cho
D000818:Animals; D003051:Cochlea / Q000502:physiology*; D004195:Disease Models, Animal; D004558:Electric Stimulation; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D006168:Guinea Pigs; D006310:Hearing Aids; D008954:Models, Biological; D012405:Round Window, Ear / Q000502:physiology*; D014159:Transducers; D014732:Vibration
animal experiment; auditory brainstem response; implantable hearing aids; oval window stimulation; round window stimulation
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