Biocompatible and High Stiffness Nanophotonic Trap Array for Precise and Versatile Manipulation.
The advent of nanophotonic evanescent field trapping and transport platforms has permitted increasingly complex single molecule and single cell studies on-chip. Here, we present the next generation of nanophotonic Standing Wave Array Traps (nSWATs) representing a streamlined CMOS fabrication process and compact biocompatible design. These devices utilize silicon nitride (Si3N4) waveguides, operate with a biofriendly 1064 nm laser, allow for several watts of input power with minimal absorption and heating, and are protected by an anticorrosive layer for sustained on-chip microelectronics in aqueous salt buffers. In addition, due to Si3N4's negligible nonlinear effects, these devices can generate high stiffness traps while resolving subnanometer displacements for each trapped particle. In contrast to traditional table-top counterparts, the stiffness of each trap in an nSWAT device scales linearly with input power and is independent of the number of trapping centers. Through a unique integration of microcircuitry and photonics, the nSWAT can robustly trap, and controllably position, a large number of nanoparticles along the waveguide surface, operating in an all-optical, constant-force mode without need for active feedback. By reducing device fabrication cost, minimizing trapping laser specimen heating, increasing trapping force, and implementing commonly used trapping techniques, this new generation of nSWATs significantly advances the development of a high performance, low cost optical tweezers array laboratory on-chip.
Department of Physics-LASSP, Cornell University , Ithaca, New York 14853, United States.|Howard Hughes Medical Institute, Cornell University , Ithaca, New York 14853, United States.
Fan
F
Ye
Department of Physics-LASSP, Cornell University , Ithaca, New York 14853, United States.
Ryan P
RP
Badman
Department of Physics-LASSP, Cornell University , Ithaca, New York 14853, United States.|Howard Hughes Medical Institute, Cornell University , Ithaca, New York 14853, United States.
James T
JT
Inman
Department of Physics-LASSP, Cornell University , Ithaca, New York 14853, United States.|Howard Hughes Medical Institute, Cornell University , Ithaca, New York 14853, United States.
Mohammad
M
Soltani
Department of Physics-LASSP, Cornell University , Ithaca, New York 14853, United States.
Jessica L
JL
Killian
Department of Physics-LASSP, Cornell University , Ithaca, New York 14853, United States.|Howard Hughes Medical Institute, Cornell University , Ithaca, New York 14853, United States.
Michelle D
MD
Wang
array traps; nanophotonics; optical trap; precise manipulation; standing wave
Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13538-43
12370445
Phys Chem Chem Phys. 2009 Jun 28;11(24):4800-3
19506753
J Biol Chem. 2011 Jun 10;286(23):20490-9
21515672
Nat Struct Mol Biol. 2009 Feb;16(2):124-9
19136959
Lab Chip. 2009 Aug 7;9(15):2212-6
19606298
Biophys J. 2004 Dec;87(6):3945-53
15465875
Phys Rev Lett. 2002 Sep 16;89(12):128301
12225126
Cell. 2007 Jun 29;129(7):1299-309
17604719
Biophys J. 2002 Aug;83(2):1098-105
12124289
Cell. 1994 Jun 3;77(5):773-84
8205624
Nature. 1993 Oct 21;365(6448):721-7
8413650
Biophys J. 2012 Oct 3;103(7):1490-9
23062341
J Mol Biol. 2005 Feb 11;346(1):135-46
15663933
Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1960-5
11854495
Opt Express. 2008 Dec 8;16(25):20987-1003
19065239
Nature. 2009 Jan 1;457(7225):71-5
19122638
Opt Express. 2012 Sep 24;20(20):22314-26
23037380
Nat Commun. 2013;4:2579
24113677
Biophys J. 1997 Mar;72(3):1335-46
9138579
Opt Express. 2009 Sep 14;17(19):17190-9
19770938
Nat Commun. 2015 Dec 17;6:10260
26675048
Science. 1996 Feb 9;271(5250):795-9
8628994
Nat Methods. 2007 Mar;4(3):223-5
17322891
Phys Rev Lett. 2003 Apr 4;90(13):133901
12689289
Mol Cell. 2005 Dec 9;20(5):771-81
16337600
Nat Struct Mol Biol. 2006 Jun;13(6):549-54
16732285
Nat Commun. 2011;2:313
21587230
Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9006-11
16751267
Science. 1998 Oct 30;282(5390):902-7
9794753
Opt Express. 2008 Aug 18;16(17):12987-94
18711537
Science. 1995 Dec 8;270(5242):1653-7
7502073
Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Oct;80(4 Pt 1):040901
19905264
Opt Lett. 2010 Sep 1;35(17):2949-51
20808379
Biophys J. 2006 Jan 15;90(2):657-67
16258039
Nano Lett. 2014 Nov 12;14(11):6475-80
25291441
Chembiochem. 2013 Oct 11;14(15):1954-7
24000171
Phys Rev Lett. 2011 Sep 2;107(10):108102
21981534
Biophys J. 2011 Jul 20;101(2):L5-7
21767475
Biophys J. 2004 Sep;87(3):1972-80
15345573
Nat Nanotechnol. 2014 Jun;9(6):448-52
24776649
Nano Lett. 2010 Jan;10(1):99-104
19957918
Nature. 1995 Nov 9;378(6553):209-12
7477328
Phys Rev Lett. 2007 Feb 9;98(6):068103
17358986
Nature. 1994 Mar 10;368(6467):113-9
8139653
Methods Enzymol. 2004;376:62-72
14975299
Opt Lett. 1996 Nov 1;21(21):1768-70
19881795
Nature. 2005 Nov 24;438(7067):460-5
16284617
Nature. 2003 Aug 14;424(6950):810-6
12917694
Nature. 2011 Sep 18;478(7367):132-5
21927003
Nano Lett. 2010 Jul 14;10(7):2408-11
20545333
Mol Cell. 2004 Jun 18;14(6):753-62
15200953
Phys Rev Lett. 2004 May 14;92(19):190801
15169392
Phys Rev Lett. 2003 Jul 11;91(2):028103
12906513
Science. 2013 Jun 28;340(6140):1580-3
23812716
Science. 1993 Apr 9;260(5105):232-4
8469975
Phys Rev Lett. 2008 Apr 11;100(14):148301
18518075
Elife. 2015 Jun 05;4:
26047462
Nature. 1987 Dec 24-31;330(6150):769-71
3320757
Phys Rev Lett. 2005 Nov 11;95(20):208102
16384102
Biophys J. 2000 Apr;78(4):1965-78
10733975
Science. 1987 Mar 20;235(4795):1517-20
3547653