Prediction of lymph node metastasis and sentinel node navigation surgery for patients with early-stage gastric cancer.
Accurate prediction of lymph node (LN) status is crucially important for appropriate treatment planning in patients with early gastric cancer (EGC). However, consensus on patient and tumor characteristics associated with LN metastasis are yet to be reached. Through systematic search, we identified several independent variables associated with LN metastasis in EGC, which should be included in future research to assess which of these variables remain as significant predictors of LN metastasis. On the other hand, even if we use these promising parameters, we should realize the limitation and the difficulty of predicting LN metastasis accurately. The sentinel LN (SLN) is defined as first possible site to receive cancer cells along the route of lymphatic drainage from the primary tumor. The absence of metastasis in SLN is believed to correlate with the absence of metastasis in downstream LNs. In this review, we have attempted to focus on several independent parameters which have close relationship between tumor and LN metastasis in EGC. In addition, we evaluated the history of sentinel node navigation surgery and the usefulness for EGC.
Atsuo Shida, Norio Mitsumori, Hiroshi Nimura, Yuta Takano, Taizou Iwasaki, Muneharu Fujisaki, Naoto Takahashi, Katsuhiko Yanaga, Department of Surgery, Jikei University School of Medicine, Tokyo 105-8461, Japan.
Atsuo
A
Shida
Atsuo Shida, Norio Mitsumori, Hiroshi Nimura, Yuta Takano, Taizou Iwasaki, Muneharu Fujisaki, Naoto Takahashi, Katsuhiko Yanaga, Department of Surgery, Jikei University School of Medicine, Tokyo 105-8461, Japan.
Norio
N
Mitsumori
Atsuo Shida, Norio Mitsumori, Hiroshi Nimura, Yuta Takano, Taizou Iwasaki, Muneharu Fujisaki, Naoto Takahashi, Katsuhiko Yanaga, Department of Surgery, Jikei University School of Medicine, Tokyo 105-8461, Japan.
Hiroshi
H
Nimura
Atsuo Shida, Norio Mitsumori, Hiroshi Nimura, Yuta Takano, Taizou Iwasaki, Muneharu Fujisaki, Naoto Takahashi, Katsuhiko Yanaga, Department of Surgery, Jikei University School of Medicine, Tokyo 105-8461, Japan.
Yuta
Y
Takano
Atsuo Shida, Norio Mitsumori, Hiroshi Nimura, Yuta Takano, Taizou Iwasaki, Muneharu Fujisaki, Naoto Takahashi, Katsuhiko Yanaga, Department of Surgery, Jikei University School of Medicine, Tokyo 105-8461, Japan.
Taizou
T
Iwasaki
Atsuo Shida, Norio Mitsumori, Hiroshi Nimura, Yuta Takano, Taizou Iwasaki, Muneharu Fujisaki, Naoto Takahashi, Katsuhiko Yanaga, Department of Surgery, Jikei University School of Medicine, Tokyo 105-8461, Japan.
Muneharu
M
Fujisaki
Atsuo Shida, Norio Mitsumori, Hiroshi Nimura, Yuta Takano, Taizou Iwasaki, Muneharu Fujisaki, Naoto Takahashi, Katsuhiko Yanaga, Department of Surgery, Jikei University School of Medicine, Tokyo 105-8461, Japan.
Naoto
N
Takahashi
Atsuo Shida, Norio Mitsumori, Hiroshi Nimura, Yuta Takano, Taizou Iwasaki, Muneharu Fujisaki, Naoto Takahashi, Katsuhiko Yanaga, Department of Surgery, Jikei University School of Medicine, Tokyo 105-8461, Japan.
Katsuhiko
K
Yanaga
D005743:Gastrectomy; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis / Q000175:diagnosis*; D000071036:Sentinel Lymph Node / Q000473:pathology; D021701:Sentinel Lymph Node Biopsy; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery*
Early-stage gastric cancer; Prediction of lymph node metastasis; Sentinel node navigation surgery
Int J Cancer. 2015 Mar 1;136(5):E359-86
25220842
Surgery. 2014 Jun;155(6):1030-5
24792508
World J Gastroenterol. 2004 Dec 15;10(24):3549-52
15534904
Ann Surg. 2007 Nov;246(5):749-53
17968165
Can J Gastroenterol. 2009 May;23(5):353-6
19440566
World J Gastroenterol. 2014 Oct 14;20(38):13842-62
25320521
Anticancer Res. 2014 Aug;34(8):4471-4
25075087
World J Gastroenterol. 2013 May 28;19(20):3096-107
23716990
Am J Surg. 2002 Feb;183(2):168-72
11918883
Gastric Cancer. 2011 Jun;14(2):113-23
21573742
AJR Am J Roentgenol. 1999 Aug;173(2):365-7
10430138
Ann Surg Oncol. 2015;22(6):1813-9
25344305
Surgery. 2001 Mar;129(3):335-40
11231462
Br J Surg. 2012 Dec;99(12):1688-92
23023388
Ann Surg Oncol. 2008 Mar;15(3):764-9
18043971
Jpn J Clin Oncol. 2001 Oct;31(10):495-9
11696619
Gastrointest Endosc. 2004 Aug;60(2):242-5
15278052
Br J Surg. 2003 Feb;90(2):178-82
12555293
Endoscopy. 2009 Jun;41(6):498-503
19533552
Gastric Cancer. 2012 Sep;15 Suppl 1:S19-26
22237654
Br J Surg. 2002 May;89(5):604-8
11972551
J Surg Oncol. 2006 Sep 15;94(4):275-80; discussion 274
16917863
World J Surg. 2014 Nov;38(11):2898-903
24934641
Eur J Cancer. 2002 Jul;38(10):1413-9
12091074
Gastric Cancer. 2000 Dec;3(4):219-225
11984739
In Vivo. 2003 Jan-Feb;17(1):41-4
12655788
BMC Cancer. 2015 Dec 01;15:943
26625983
World J Gastroenterol. 2014 May 21;20(19):5685-93
24914329
Histopathology. 2005 Feb;46(2):158-65
15693888
World J Gastroenterol. 2010 Nov 7;16(41):5252-6
21049560
Jpn J Clin Oncol. 1984 Jun;14(2):283-93
6737715
Gastric Cancer. 2007;10(2):117-22
17577622
Cancer Sci. 2011 Aug;102(8):1559-64
21564421
Gastric Cancer. 2013 Oct;16(4):521-30
23179370
Scand J Gastroenterol. 2016 Jan;51(1):48-54
26200504
Gastric Cancer. 2013 Jan;16(1):1-27
22729699
Jpn J Clin Oncol. 2008 Apr;38(4):259-67
18344316
Ann Surg Oncol. 2010 Jan;17(1):73-80
19777179
Eur J Surg Oncol. 2009 May;35(5):449-55
19147324
Virchows Arch. 2009 Feb;454(2):143-51
19104832
Gastric Cancer. 2012 Jul;15(3):287-91
22041868
World J Surg. 2004 Mar;28(3):247-53
14961197
Gastric Cancer. 2006;9(3):192-6
16952037
Ann Surg Oncol. 2007 Feb;14(2):340-7
17094028
J Gastrointest Surg. 2011 Oct;15(10):1783-8
21796460
Endoscopy. 2008 Jan;40(1):7-10
18210339
Surg Endosc. 2013 Sep;27(9):3247-53
23508816
Ann Surg Oncol. 2006 Nov;13(11):1364-71
16957964
Gastric Cancer. 2016 Oct;19(4):1041-51
26573601
J Surg Oncol. 2007 Oct 1;96(5):429-35
17786966
J Surg Oncol. 2004 Mar 15;85(4):181-5; discussion 186
14991872
Br J Surg. 2004 May;91(5):575-9
15122608
Lancet Oncol. 2010 May;11(5):439-49
20409751
Eur J Surg Oncol. 2010 Jun;36(6):552-8
20452171
Histopathology. 2004 May;44(5):437-44
15139991
Eur J Surg Oncol. 2004 Nov;30(9):935-41
15498637
J Surg Oncol. 2011 Nov 1;104(6):578-84
21695700