Gender Associated Lipid and Apolipoprotein Profile in Patients with Age-Related Macular Degeneration.
The role of lipid parameters disorder in the development of age-related macular degeneration (AMD) is unclear. The aim of this study was to analyze lipid profile in these patients and to test the influence of gender on lipid profile of AMD patients, especially in the early and late form of the disease. 82 patients with AMD (mean age 70.3 yrs) and 80 age-matched control subjects were included in this study. Serum lipid and apolipoproteiin levels were determined using standardized methods. AMD patients had significantly higher values of total cholesterol (P=0.000), HDL-cholesterol (P=0.0003) and LDL-cholesterol (P=0.000) compared to control group. Significantly higher values of apo A1 (P=0.039), apo E (P=0.002), total-cholesterol (P=0.000), LDL-chol. (P=0.026), total HDL-chol (P=0.000), HDL3-chol. (P=0.005) and non-HDL-cholesterol (P=0.029) were found in female AMD patients compared to males with AMD. Females with the advanced form of the disease had significantly higher total cholesterol (P=0.006), HDL-C (P=0.004), non HDL-C (P=0.05) and apo E (P=0.014) compared to males with the same form of the disease. There is a significant disorder of lipid parameters in AMD patients especially in females. More severe forms of AMD are followed by the increase of atherogenic lipoproteins and apolipoproteins, and females have higher values of these parameters compared to males with the same form of AMD.
Institute of Medical Biochemistry, Clinical Center of Serbia , Belgrade, Serbia.
Emina S
ES
Colak
Institute of Medical Biochemistry, Clinical Center of Serbia , Belgrade, Serbia.
Nada T
NT
Majkic-Singh
Institute of Medical Biochemistry, Clinical Center of Serbia , Belgrade, Serbia.
Sanja S
SS
Stankovic
Institute of Ophthalmology, Medical Retina Department, Clinical Center of Serbia , Belgrade, Serbia.
Natalija G
NG
Kosanovic-Jakovic
Institute of Ophthalmology, Medical Retina Department, Clinical Center of Serbia , Belgrade, Serbia.
Lepsa D
LD
Zoric
Institute of Ophthalmology, Medical Retina Department, Clinical Center of Serbia , Belgrade, Serbia.
Aleksandra P
AP
Radosavljevic
Institute of Medical Biochemistry, Clinical Center of Serbia , Belgrade, Serbia.
Dragana D
DD
Terzic
Institute of Medical Biochemistry, Clinical Center of Serbia , Belgrade, Serbia.
Jecka Z
JZ
Stojanovic
Am J Ophthalmol. 2001 Nov;132(5):668-81
11704028
Arch Ophthalmol. 2004 Apr;122(4):598-614
15078679
Arch Ophthalmol. 1967 Mar;77(3):410-20
6019564
Ophthalmology. 2002 Oct;109(10):1767-79
12359593
Lancet. 2008 Nov 22;372(9652):1835-45
19027484
Arch Ophthalmol. 1992 Dec;110(12):1701-8
1281403
Invest Ophthalmol Vis Sci. 1999 Mar;40(3):775-9
10067983
Ophthalmologe. 1994 Dec;91(6):730-4
7849423
Arch Ophthalmol. 1994 Mar;112(3):402-6
8129668
Clin Biochem. 2001 Mar;34(2):149-55
11311225
Invest Ophthalmol Vis Sci. 1989 Mar;30(3):478-86
2925318
Invest Ophthalmol Vis Sci. 2003 Mar;44(3):1221-9
12601052
Circ Res. 2005 Jun 24;96(12 ):1221-32
15976321
Ophthalmology. 1993 Oct;100(10):1519-35
7692366
Exp Eye Res. 2010 Jan;90(1):10-6
19799898
Ophthalmology. 1992 Jun;99(6):933-43
1630784
Arch Ophthalmol. 1999 Mar;117(3):329-39
10088810
Vojnosanit Pregl. 2008 Apr;65(4):313-8
18499954
Arch Ophthalmol. 1992 Jan;110(1):15-6
1731712
Br J Ophthalmol. 2006 Aug;90(8):1028-33
16723359
Am J Ophthalmol. 1998 Mar;125(3):353-9
9512153