Abdominal obesity and structure and function of the heart in healthy male Koreans: The ARIRANG study.
Although central obesity is a more powerful predictor of cardiovascular disease (CVD) than general obesity, there is limited information on structural and functional changes of the heart in central obesity. Therefore, we evaluated the association between abdominal obesity and geometric and functional changes of the heart in healthy males. A total of 1460 healthy males aged 40 to 70 years without known CVD from the Korean Genome and Epidemiology Study on Atherosclerosis Risk of Rural Areas in the Korean General Population were included. All individuals underwent conventional 2-dimensional echocardiography and tissue Doppler imaging to measure left atrial (LA) and left ventricle (LV) geometry and function. Increasing tertiles of waist circumference (WC) were associated with stepwise increases in LA volume, LV end-diastolic dimension, LV mass to height, deceleration time of E wave, and lower E/A ratio (all P trends <0.001). In multivariable logistic regression models, the odds ratios for LA enlargement, LV hypertrophy, LV enlargement, and diastolic dysfunction comparing the upper tertile of WC (>89 cm) to the lowest tertile (<82 cm) were 2.81 (95% confidence interval [CI] 2.24-3.54), 3.65 (95% CI 2.54-5.26), 4.23 (95% CI 2.61-6.87), and 1.75 (95% CI 1.37-2.22), respectively. LV ejection fraction and relative wall thickness were not increased with increasing WC. The association between WC and LA enlargement, LV enlargement, and diastolic dysfunction persisted after stratification by body mass index tertiles. Central obesity may be a stronger predictor than general obesity of geometric and functional changes in the LV and LA.
aDepartment of Internal Medicine, Division of Cardiology, Yonsei University, Wonju College of Medicine, Wonju bDivision of Cardiology, Andong Medical Group Hospital, Andong cDepartment of Preventive Medicine and Institute of Occupational Medicine dInstitute of Genomic Cohort, Yonsei University, Wonju College of Medicine, Wonju, Republic of Korea.
Jung-Woo
JW
Son
Joong Kyung
JK
Sung
Jun-Won
JW
Lee
Young Jin
YJ
Youn
Min-Soo
MS
Ahn
Sung Gyun
SG
Ahn
Byung-Su
BS
Yoo
Seung-Hwan
SH
Lee
Junghan
J
Yoon
Sang Baek
SB
Koh
Jang-Young
JY
Kim
D000328:Adult; D000368:Aged; D016279:Atrial Function, Left; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000209:etiology*; D004452:Echocardiography; D064368:Healthy Volunteers; D006325:Heart Atria / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D056128:Obesity, Abdominal / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D056910:Republic of Korea; D012307:Risk Factors; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D016277:Ventricular Function, Left; D055105:Waist Circumference
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