Recurrence rate in regional lymph nodes in 737 patients with follicular or Hürthle cell neoplasms.
BACKGROUND
Preoperative ultrasound (US) evaluation of central and lateral neck compartments is recommended for all patients undergoing a thyroidectomy for malignant or suspicious for malignancy cytologic or molecular findings. Our aim was to find out how frequent was recurrence in regional lymph nodes in patients with follicular or Hürthle cell neoplasm and usefulness of preoperative neck US investigation in patients with neoplasm.


METHODS
Altogether 737 patients were surgically treated because of follicular or Hürthle cell neoplasms from 1995 to 2014 at our cancer comprehensive center, among them 207 patients (163 females, 44 males; mean age 52 years) had thyroid carcinoma.


RESULTS
Carcinoma was diagnosed in follicular and Hürthle cell neoplasm in 143/428 and 64/309 of cases, respectively. A recurrence in regional lymph nodes occurred in 12/207 patients (6%) during a median follow-up of 55 months. Among patients with carcinoma a recurrence in regional lymph nodes was diagnosed in follicular and Hürthle cell neoplasms in 2% and 14%, respectively (p = 0.002). Recurrence in regional lymph nodes was diagnosed in 3/428 of all patients with follicular neoplasm and 9/309 of all patients with Hürthle cell neoplasm.


CONCLUSIONS
Recurrence in lymph nodes was diagnosed in 0.7% of patients with a preoperative diagnosis of follicular neoplasm and 3% of patients with a Hürthle cell neoplasm. A recurrence in regional lymph nodes is rare in patients with carcinoma and preoperative diagnosis of follicular neoplasm. Preoperative neck ultrasound examination in patients with a follicular neoplasm is probably not useful, but in patients with Hurtle cell neoplasm it may be useful.
Department of Radiology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.
Andrej
A
Vogrin
Department of Surgical Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.
Hana
H
Besic
Department of Surgical Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.
Nikola
N
Besic
Department of Radiology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.
Maja Marolt
MM
Music
diagnosis; pathology; recurrence; thyroid neoplasms; ultrasonography
Clin Endocrinol (Oxf). 2004 Jan;60(1):21-8
14678283
Thyroid. 2007 Dec;17(12):1269-76
17988196
Thyroid. 2010 Dec;20(12):1341-9
21034228
Endocr J. 2012;59(2):119-25
22068114
Radiol Oncol. 2015 Mar 25;49(2):121-7
26029022
Arch Surg. 2006 May;141(5):489-94; discussion 494-6
16702521
Diagn Cytopathol. 2008 Jun;36(6):425-37
18478609
J Surg Oncol. 2012 Mar 15;105(4):351-6
21751218
Thyroid. 2009 Nov;19(11):1167-214
19860577
Eur J Endocrinol. 2008 Dec;159(6):659-73
18713843
Eur J Surg Oncol. 2006 May;32(4):458-61
16497473
BMC Cancer. 2014 Oct 23;14:777
25338674
Head Neck. 1999 Sep;21(6):506-11
10449665
Thyroid. 1999 May;9(5):421-7
10365671
Surgery. 2013 Oct;154(4):697-701; discussion 701-3
24011674
J Surg Oncol. 2010 Jun 1;101(7):582-6
20461764
Eur J Surg Oncol. 2009 Mar;35(3):230-4
18722077
Ann Surg Oncol. 2002 Mar;9(2):197-203
11888879
J Natl Compr Canc Netw. 2022 Aug;20(8):925-951
35948029
World J Surg. 2008 May;32(5):729-39
18064515
Acta Cytol. 2012;56(4):333-9
22846422
World J Surg. 1994 Jul-Aug;18(4):559-67; discussion 567-8
7725745
Eur J Clin Invest. 2009 Aug;39(8):699-706
19601965
World J Surg. 2002 Aug;26(8):879-85
12016468
J Surg Oncol. 2008 Mar 1;97(3):221-5
18050283