Interleukin-6 receptor-alpha signaling drives anti-RBC alloantibody production and T-follicular helper cell differentiation in a murine model of red blood cell alloimmunization.
Department of Pathology, University of Virginia, Charlottesville, VA, USA.
Abhinav
A
Arneja
Department of Pathology, University of Virginia, Charlottesville, VA, USA.
Juan E
JE
Salazar
Department of Pathology, Brigham & Women's Hospital, Boston, MA, USA.
Wenyu
W
Jiang
Departments of Laboratory Medicine and Pediatrics, Yale University, New Haven, CT, USA.
Jeanne E
JE
Hendrickson
Bloodworks NW Research Institute and the Department of Laboratory Medicine and the Department of Medicine, Division of Hematology, University of Washington School of Medicine, Seattle, WA, USA.
James C
JC
Zimring
Department of Pathology, University of Virginia, Charlottesville, VA, USA cjl4y@virginia.edu.
Chance John
CJ
Luckey
D000818:Animals; D002454:Cell Differentiation; D004912:Erythrocytes / Q000276:immunology*; D007518:Isoantibodies / Q000096:biosynthesis*; D051379:Mice; D019947:Receptors, Interleukin-6 / Q000502:physiology*; D015398:Signal Transduction / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology*
D007518:Isoantibodies; D019947:Receptors, Interleukin-6; C113250:interleukin-6 receptor alpha
IL-6R expression; RBC alloimmunization; T-follicular helper cell differentiation
N Engl J Med. 2007 Nov 8;357(19):1903-15
17989383
J Immunol. 2010 Jul 1;185(1):313-26
20519643
Immunity. 2011 Jun 24;34(6):932-46
21636296
J Exp Med. 2012 Oct 22;209(11):2049-64
23045607
Immunity. 2008 Jul 18;29(1):138-49
18599325
PLoS One. 2011 Mar 14;6(3):e17739
21423809
Blood. 2010 May 27;115(21):4284-92
20299509
Transfusion. 2010 Mar;50(3):642-8
19906034
Blood. 2010 May 13;115(19):3989-96
20086249
J Exp Med. 2012 Jul 2;209(7):1241-53
22753927
Transfusion. 2009 Mar;49(3):505-12
19040411
Br J Haematol. 1995 Dec;91(4):1000-5
8547111
Elife. 2014 May 19;3:e01949
24842874
J Immunol. 2010 Jun 15;184(12):7219-28
20483735
Blood. 2009 Sep 10;114(11):2315-22
19525479