Protective effects of vitamin E on sodium arsenite-induced toxicity, testicular measurements and histopathological studies of testes in Teddy goat bucks.
The objective of this study was to investigate the toxic effects of arsenic on testicular measurements and histology of adult Teddy goats bucks and to examine whether these toxic effects are scavenged by vitamin E. Twelve adult Teddy goat bucks were divided randomly into three groups, A, B and C. Group A was kept as control, the B was given sodium arsenite 5 mg/kg BW per day, and group C was fed with vitamin E 200 mg/kg BW per day + arsenic 5 mg/kg BW per day. This treatment was continued for 84 days. Analysis of data revealed that the testicular measurements (scrotal circumference, width, length and weight) were significantly reduced in arsenic-treated animals, whereas there were ameliorating effects of vitamin E on these parameters. The major histopathological changes were present in the form of loss of germinal epithelium, atrophy of Leydig cells and vacuolations. Vitamin E in combination with sodium arsenite increased the active spermatogenesis as well as restoration of germinal epithelium. It can be concluded from the present findings that sodium arsenite causes toxicity in the male reproductive system of Teddy goat bucks with major changes in parenchyma of testes. Supplementation of vitamin E has protective effects on the toxicity of sodium arsenite on the reproductive system of male Teddy goat bucks.
Department of Theriogenology, University of Agriculture, Faisalabad, Pakistan.
M
M
Zubair
Department of Theriogenology, University of Agriculture, Faisalabad, Pakistan.
M
M
Ahmad
Department of Pathology, University of Agriculture, Faisalabad, Pakistan.
M K
MK
Saleemi
Department of Pathology, University of Agriculture, Faisalabad, Pakistan.
S T
ST
Gul
Department of Theriogenology, University of Agriculture, Faisalabad, Pakistan.
N
N
Ahmad
Department of Theriogenology, University of Agriculture, Faisalabad, Pakistan.
S
S
Umar
D000818:Animals; D018053:Arsenites / Q000633:toxicity*; D019587:Dietary Supplements; D006041:Goats; D007985:Leydig Cells / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D012611:Scrotum / Q000473:pathology; D017670:Sodium Compounds / Q000633:toxicity*; D013091:Spermatogenesis / Q000187:drug effects; D013737:Testis / Q000187:drug effects* / Q000473:pathology*; D014810:Vitamin E / Q000008:administration & dosage*
D018053:Arsenites; D017670:Sodium Compounds; D014810:Vitamin E; C017947:sodium arsenite
Teddy goat bucks; histopathology; sodium arsenite and testes; testicular measurements