Cervicovaginal Inflammation Facilitates Acquisition of Less Infectious HIV Variants.
We evaluated whether genital inflammation affects the selection of the transmitted virus. Among South African women, we found that preinfection genital inflammation facilitates transmission of less infectious human immunodeficiency virus, but highly infectious viruses are able to establish infection regardless of inflammation status. This suggests that viral phenotype can influence transmission risk.
Institute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town and National Health Laboratory Services.
Philippe
P
Selhorst
Institute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town and National Health Laboratory Services.|Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban.
Lindi
L
Masson
Institute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town and National Health Laboratory Services.
Sherazaan D
SD
Ismail
Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban.
Natasha
N
Samsunder
Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban.
Nigel
N
Garrett
Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban.
Leila E
LE
Mansoor
Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban.|Department of Epidemiology, Columbia University, New York.
Quarraisha
Q
Abdool Karim
Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban.|Department of Epidemiology, Columbia University, New York.
Salim S
SS
Abdool Karim
Institute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town and National Health Laboratory Services.|Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban.|National Health Laboratory Service, Cape Town, South Africa.
Jo-Ann S
JS
Passmore
Institute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town and National Health Laboratory Services.|National Health Laboratory Service, Cape Town, South Africa.
Carolyn
C
Williamson
D015415:Biomarkers; D016207:Cytokines / Q000097:blood; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000150:complications* / Q000188:drug therapy / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics*; D006801:Humans; D010802:Phylogeny; D002575:Uterine Cervicitis / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D014627:Vaginitis / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D019562:Viral Load
D015415:Biomarkers; D016207:Cytokines
HIV acquisition; cytokine; female genital tract; inflammation; viral infectivity
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