Myeloperoxidase as a Potential Target in Women With Endometriosis Undergoing IVF.
As infertility is intimately associated with endometriosis, the levels of myeloperoxidase (MPO), a leukocyte enzyme and an oxidative stress marker, were determined in a case-control prospective study of 68 women with and without endometriosis undergoing in vitro fertilization in the outpatient fertility center within a tertiary care academic medical center. Measured values included plasma and follicular fluid (FF) concentrations of MPO, plasma estradiol, as well as oocyte quality, fertilization, implantation, and pregnancy rates in these women. In FF (mean ± standard error of mean [SEM]), the MPO concentrations (ng/mL) for controls were 4.3 ± 0.37, mild endometriosis (stages I-II) 3.9 ± 0.17, and moderate/severe endometriosis (stages III-IV) 16.6 ± 12.5 ( P < 0.0143). In FF, among patients supplemented with vitamins E and C, the MPO levels decreased significantly only in moderate/severe endometriosis from 25.3 ± 22.0 ng/mL to 4.9 ± 1.61 ng/mL, respectively. Plasma levels of MPO between groups did not change. Outcome data revealed a trend toward decreased percentage of mature oocytes, implantation rate, and clinical pregnancy rate with severity of endometriosis and MPO levels. Myeloperoxidase may be a potential oxidative stress target for endometriosis-associated infertility.
1 Department of Gynecology & Obstetrics, Emory University School of Medicine, Atlanta, GA, USA.|2 Department of Pharmacology, Physiology & Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA.
Nalini
N
Santanam
1 Department of Gynecology & Obstetrics, Emory University School of Medicine, Atlanta, GA, USA.|3 Advanced Fertility Care, Scottsdale, AZ, USA.
Nathaniel
N
Zoneraich
1 Department of Gynecology & Obstetrics, Emory University School of Medicine, Atlanta, GA, USA.|4 Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA.
Sampath
S
Parthasarathy
D000328:Adult; D004624:Embryo Transfer; D004715:Endometriosis / Q000097:blood / Q000378:metabolism*; D005260:Female; D005307:Fertilization in Vitro; D015571:Follicular Fluid / Q000378:metabolism; D006801:Humans; D009865:Oocytes / Q000378:metabolism*; D010062:Ovulation Induction; D018384:Oxidative Stress / Q000502:physiology; D009195:Peroxidase / Q000097:blood / Q000378:metabolism*; D011247:Pregnancy; D018873:Pregnancy Rate; D055815:Young Adult
D009195:Peroxidase
antioxidants; infertility; oxidative stress
J Soc Gynecol Investig. 2006 Sep;13(6):390-8
16872846
Reprod Biomed Online. 2013 Apr;26(4):345-52
23415995
Endocrinology. 1995 Jan;136(1):242-52
7828537
Fertil Steril. 2008 Dec;90(6):2080-5
18249400
J Pak Med Assoc. 2009 Jan;59(1):30-4
19213374
Pain. 2015 Mar;156(3):528-39
25599233
Int J Immunopathol Pharmacol. 2004 Sep-Dec;17(3):389-93
15461873
Hum Reprod. 2003 Nov;18(11):2270-4
14585872
J Reprod Med. 2013 Jan-Feb;58(1-2):34-8
23447916
Life Sci. 2004 Oct 1;75(20):2425-38
15350818
J Assist Reprod Genet. 2012 Oct;29(10):1083-9
22798064
Hum Reprod. 2015 Jan;30(1):49-60
25376454
Mol Hum Reprod. 2008 Jul;14(7):377-85
18508952
J Pineal Res. 2008 Apr;44(3):280-7
18339123
Reprod Toxicol. 2010 Jul;29(4):447-51
20406678
Cochrane Database Syst Rev. 2013 Aug 05;(8):CD007807
23913583
Fertil Steril. 1994 Mar;61(3):488-95
8137972
J Reprod Immunol. 2002 Oct-Nov;57(1-2):47-60
12385833
Front Surg. 2014 Jul 02;1:24
25593948
Eur J Obstet Gynecol Reprod Biol. 2013 Nov;171(1):193
24182968
Fertil Steril. 2010 Nov;94(6):2465-6
20226443
Jpn J Infect Dis. 2004 Oct;57(5):S1-2
15507751
Reprod Biomed Online. 2005 Nov;11(5):641-50
16409717
Semin Reprod Endocrinol. 1998;16(4):263-73
10101808
Antioxid Redox Signal. 2001 Dec;3(6):1139-46
11813987
Curr Opin Obstet Gynecol. 2006 Jun;18(3):325-32
16735834
J Reprod Fertil Suppl. 2000;55:109-19
10889840
Gynecol Endocrinol. 2009 Feb;25(2):75-81
19253102
Eur J Obstet Gynecol Reprod Biol. 2013 Jun;168(2):187-90
23351670
Semin Reprod Med. 2013 Mar;31(2):109-24
23446858
Curr Med Chem. 2008;15(6):604-13
18336275
Antioxid Redox Signal. 2008 Aug;10(8):1375-403
18402550
Fertil Steril. 2008 Aug;90(2):247-57
18672121
Biomed Res Int. 2014;2014:916212
24900998
J Soc Gynecol Investig. 2006 Sep;13(6):451-8
16879991
J Leukoc Biol. 2005 May;77(5):598-625
15689384
J Clin Endocrinol Metab. 1998 Jun;83(6):2110-3
9626147
Reprod Biol Endocrinol. 2012 Jun 29;10:49
22748101
Eur J Obstet Gynecol Reprod Biol. 2012 Oct;164(2):127-32
22771225
Int J Clin Exp Pathol. 2014 Apr 15;7(5):2273-82
24966936
Curr Drug Metab. 2015;16(3):168-90
26279325
Hum Reprod. 1998 Aug;13(8):2186-91
9756294
Fertil Steril. 2014 Jul;102(1):151-159.e5
24825428
Fertil Steril. 2008 Apr;89(4):912-21
17681319
Fertil Steril. 1997 May;67(5):817-21
9130884
J Lipid Res. 1998 Nov;39(11):2111-8
9799796
Free Radic Res. 2002 Dec;36(12):1315-21
12607823
Fertil Steril. 2012 Jul;98 (1):126-30
22578534
Mol Hum Reprod. 2003 Nov;9(11):639-43
14561807
Fertil Steril. 1999 Jun;71(6):1115-8
10360920
Reprod Fertil Dev. 2013;25(2):351-61
22951090
Biol Reprod. 1993 Apr;48(4):905-9
8387350
Transl Res. 2013 Mar;161(3):189-95
22728166
Ann N Y Acad Sci. 2002 Mar;955:183-98; discussion 19-200, 396-406
11949947
Arch Gynecol Obstet. 2012 Oct;286(4):1033-40
22791380
Hum Reprod. 1993 Oct;8(10):1762-75
8300842