Ectopic Cushing's syndrome due to retroperitoneal ACTH-producing paragangliomas.
Extra-adrenal pheochromocytomas, or paragangliomas, are rare tumours that derive from extra-adrenal chromaffin cells. Cushing's syndrome (CS) caused by paragangliomas is extremely rare. We report a 53-year-old man with hypertension, diabetes, and symptoms of hypokalemia. Computer tomography (CT) revealed two retroperitoneal masses and bilateral adrenal hyperplasia. Together with the laboratory examinations, ectopic CS caused by multiple paragangliomas was highly suspected. The patient underwent resections of retroperitoneal tumours, left kidney, and left adrenal; postoperative histopathology confirmed two paragangliomas that were both positively stained for adrenocorticotropic hormone (ACTH). He got clinical and biochemical recoveries without any recurrent evidence at the nine-month followup.
Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong, China;; College of Medicine, University of Kentucky, Lexington, KY, United States.
Fan
F
Chen
Department of Urology, The People's Hospital of Liaocheng, Liaocheng, Shandong, China.
Xiangyu
X
Wang
Department of Urology, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Yang
Y
Wang
Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong, China.
Hui
H
Meng
Department of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong, China.
Xinguo
X
Hou
Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong, China.
Yaofeng
Y
Zhu
Department of Pathology, Qilu Hospital, Shandong University, Jinan, Shandong, China;; Department of Pathology, Jinan Central Hospital, Shandong University, Jinan, Shandong, China.
Wei
W
Gao
Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong, China.
Xuewen
X
Jiang
Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong, China.
Shouzhen
S
Chen
Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong, China.
Zhaocun
Z
Zhang
Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong, China.
Zhichuan
Z
Zou
Department of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong, China.
Tianyi
T
He
Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong, China.
Yue
Y
Yang
Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong, China.
Kejia
K
Zhu
Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong, China.
Yong
Y
Wang
Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong, China.
Yaxiao
Y
Liu
Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong, China.
Jianfeng
J
Cui
Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong, China.
Benkang
B
Shi
Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong, China.
Gang
G
Yin
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