Gene Mutations Associated with Temporomandibular Joint Disorders: A Systematic Review.
BACKGROUND
The temporomandibular joint (TMJ) is a bilateral synovial joint between the mandible and the temporal bone of the skull. TMJ disorders (TMDs) are a set of complicated and poorly understood clinical conditions, in which TMDs are associated with a number of symptoms including pain and limited jaw movement. The increasing scientific evidence suggests that genetic factors play a significant role in the pathology of TMDs. However, the underlying mechanism of TMDs remains largely unknown.


OBJECTIVE
The study aimed to determine the associated genes to TMDs in humans and animals.


METHODS
The literature search was conducted through databases including Medline (Ovid), EMBASE (Ovid), and PubMed (NLM) by using scientific terms for TMDs and genetics in March 2015. Additional studies were identified by searching bibliographies of highly relevant articles and Scopus (Elsevier).


RESULTS
Our systematic analyses identified 31 articles through literature searches. A total of 112 genes were identified to be significantly and specifically associated with TMDs.


CONCLUSIONS
Our systematic review provides a list of accurate genes associated with TMDs and suggests a genetic contribution to the pathology of TMDs.
Department of Epidemiology, Human Genetics & Environmental Sciences, The University of Texas School of Public Health, Houston, TX, USA; Department of Diagnostic & Biomedical Sciences, The University of Texas Health Science Center at Houston School of Dentistry, Houston, TX, USA.
Dhruvee
D
Sangani
Department of Diagnostic & Biomedical Sciences, The University of Texas Health Science Center at Houston School of Dentistry, Houston, TX, USA; Center for Craniofacial Research, The University of Texas Health Science Center at Houston School of Dentistry, Houston, TX, USA.
Akiko
A
Suzuki
The University of Texas School of Public Health Library, Houston, TX, USA.
Helena
H
VonVille
Department of Epidemiology, Human Genetics & Environmental Sciences, The University of Texas School of Public Health, Houston, TX, USA.
James E
JE
Hixson
Department of Diagnostic & Biomedical Sciences, The University of Texas Health Science Center at Houston School of Dentistry, Houston, TX, USA; Center for Craniofacial Research, The University of Texas Health Science Center at Houston School of Dentistry, Houston, TX, USA; The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX, USA.
Junichi
J
Iwata
Systematic Review; Temporomandibular Joint; Temporomandibular Joint Disorders
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