Microbiome, Metabolome and Inflammatory Bowel Disease.
Inflammatory Bowel Disease (IBD) is a multifactorial disorder that conceptually occurs as a result of altered immune responses to commensal and/or pathogenic gut microbes in individuals most susceptible to the disease. During Crohn's Disease (CD) or Ulcerative Colitis (UC), two components of the human IBD, distinct stages define the disease onset, severity, progression and remission. Epigenetic, environmental (microbiome, metabolome) and nutritional factors are important in IBD pathogenesis. While the dysbiotic microbiota has been proposed to play a role in disease pathogenesis, the data on IBD and diet are still less convincing. Nonetheless, studies are ongoing to examine the effect of pre/probiotics and/or FODMAP reduced diets on both the gut microbiome and its metabolome in an effort to define the healthy diet in patients with IBD. Knowledge of a unique metabolomic fingerprint in IBD could be useful for diagnosis, treatment and detection of disease pathogenesis.
Department of Surgery, University of Kansas Medical Center, 3901 Rainbow Blvd, 4028 Wahl Hall East, Kansas City, KS 66160, USA. iahmed@kumc.edu.
Ishfaq
I
Ahmed
Department of Surgery, University of Kansas Medical Center, 3901 Rainbow Blvd, 4028 Wahl Hall East, Kansas City, KS 66160, USA. broy@kumc.edu.
Badal C
BC
Roy
Department of Internal Medicine and Department of Pediatrics, University of Missouri, Kansas City, MO 64110, USA. khansal@umkc.edu.
Salman A
SA
Khan
Department of Internal Medicine and Department of Pediatrics, University of Missouri, Kansas City, MO 64110, USA. ssepter@cmh.edu.
Seth
S
Septer
Department of Surgery, University of Kansas Medical Center, 3901 Rainbow Blvd, 4028 Wahl Hall East, Kansas City, KS 66160, USA. sumar@kumc.edu.
Shahid
S
Umar
dysbiosis; inflammation bowel diseases; metabolites; metabolome; microbiome; prebiotics; probiotics
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