Discriminating Nevi from Melanomas: Clues and Pitfalls.
Reflectance confocal microscopy (RCM) together with dermoscopy enables improved differentiation of melanomas from most nevi. The resulting high sensitivity for detecting melanoma with RCM is complemented by a concomitant increased specificity, which results in the reduction of unnecessary biopsies of nevi. Although RCM can achieve high diagnostic accuracy for early melanoma detection, false-negative and false-positive cases of melanoma are occasionally encountered. This article reviews the essential clues and pitfalls for the diagnosis of melanoma via RCM and highlights the importance of evaluating RCM findings in light of the clinical scenario and dermoscopic features.
Melanoma Unit, Department of Dermatology, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, CIBER de Enfermedades Raras, Instituto de Salud Carlos III, University of Barcelona, Villarroel 170, Escala 1-4, Barcelona 08036, Spain.
Cristina
C
Carrera
Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 800 Veterans Memorial Highway, 2nd Floor, Hauppauge, NY 11788, USA. Electronic address: marghooa@mskcc.org.
Ashfaq A
AA
Marghoob
D046169:Dermoscopy; D003937:Diagnosis, Differential; D006801:Humans; D000069416:Intravital Microscopy; D008545:Melanoma / Q000000981:diagnostic imaging*; D018328:Melanoma, Amelanotic / Q000000981:diagnostic imaging*; D018613:Microscopy, Confocal; D009506:Nevus / Q000000981:diagnostic imaging*; D009508:Nevus, Pigmented / Q000000981:diagnostic imaging*; D012878:Skin Neoplasms / Q000000981:diagnostic imaging*
Atypical nevi; Confocal; Diagnostic accuracy; Differential diagnosis; Early detection; Melanoma; Nevus
Australas J Dermatol. 2016 Feb;57(1):72-3
26820787
J Am Acad Dermatol. 2012 Jul;67(1):e17-27
21683472
J Am Acad Dermatol. 2012 Nov;67(5):836-45
22521205
Australas J Dermatol. 2012 Nov;53(4):291-4
22497519
J Am Acad Dermatol. 2012 Mar;66(3):e109-21
21742408
J Am Acad Dermatol. 2009 Feb;60(2):236-47
19091443
Dermatology. 2016;232(2):189-97
26862920
J Med Genet. 2011 Mar;48(3):168-76
21097776
J Eur Acad Dermatol Venereol. 2013 Feb;27(2):e159-65
22486883
J Invest Dermatol. 2014 May;134(5):1351-8
24304815
Br J Dermatol. 2014 Nov;171(5):1044-51
24891083
JAMA Dermatol. 2015 May;151(5):544-8
25651238
J Am Acad Dermatol. 2007 Jul;57(1):96-104
17485141
Cancer. 2012 Nov 1;118(21):5395-402
22517033
J Eur Acad Dermatol Venereol. 2015 Jan;29(1):102-8
24646029
Dermatol Surg. 2010 Jul;36(7):1087-98
20653722
Arch Dermatol. 1998 Jul;134(7):845-50
9681348
Arch Dermatol. 1998 Dec;134(12):1563-70
9875194
J Eur Acad Dermatol Venereol. 2013 Jul;27(7):805-14
23181611
Br J Dermatol. 2013 May;168(5):1027-33
23301553
Acta Derm Venereol. 2011 Mar;91(2):137-46
21240454
Br J Dermatol. 2008 Sep;159(3):669-76
18616769
J Invest Dermatol. 2007 Dec;127(12):2759-65
17657243
Br J Dermatol. 2014 Jul;171(1):48-54
24329036
J Eur Acad Dermatol Venereol. 2015 Jun;29(6):1135-40
25303304
Arch Dermatol. 2012 Feb;148(2):174-8
22351816
JAMA Dermatol. 2013 Jul;149(7):803-13
23699984
Arch Dermatol. 2008 Jan;144(1):58-64
18209169
J Am Acad Dermatol. 2011 Sep;65(3):604-14
21715047
Dermatol Pract Concept. 2013 Oct 31;3(4):19-27
24282659
Dermatol Pract Concept. 2014 Jul 31;4(3):67-71
25126463
J Am Acad Dermatol. 2009 Aug;61(2):216-29
19406506
Arch Dermatol. 2008 Oct;144(10):1311-20
18936395
Br J Dermatol. 2013 Jul;169(1):58-67
23374159
J Am Acad Dermatol. 2012 Feb;66(2):212-9
21757257
Ann Transl Med. 2015 Sep;3(15):210
26488006
Br J Dermatol. 2013 Jun;168(6):1230-5
23302038
Br J Dermatol. 2014 Apr;170(4):802-8
24124911
Br J Dermatol. 2015 Feb;172(2):313-5
25660675
Arch Dermatol. 2011 Jan;147(1):46-9
21242392
J Invest Dermatol. 2005 Sep;125(3):532-7
16117795
Br J Dermatol. 2015 Feb;172(2):365-71
25154446
J Am Acad Dermatol. 2012 Mar;66(3):452-62
21798622
Br J Dermatol. 2004 Apr;150(4):687-92
15099364
J Am Acad Dermatol. 2012 Jul;67(1):54-9
21982636
Arch Dermatol. 2003 Mar;139(3):282-8
12622618
Dermatology. 2012;224(4):295-300
22722537
Dermatology. 2013;227(2):109-17
24080548
J Eur Acad Dermatol Venereol. 2015 Oct;29(10):1918-25
25752663
Br J Dermatol. 2011 Jul;165(1):61-8
21410674