Curacin E from the Brittle Star Ophiocoma scolopendrina.
Bioassay-guided fractionation of the extract of the brittle star Ophiocoma scolopendrina afforded curacin E (1), a congener of curacin A (2). Curacin A (2) is an antimitotic agent of cyanobacterial origin. The structure of curacin E was studied by interpretation of NMR data and the ECD spectrum. Curacin E has an ethylcarbonyl terminus in its side chain and inhibits the proliferation of P388 cells.
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo , Bunkyo-ku, Tokyo 113-8657, Japan.
Reiko
R
Ueoka
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo , Bunkyo-ku, Tokyo 113-8657, Japan.
Yuki
Y
Hitora
Chemical Genomics Reserach Group, RIKEN Center for Sustainable Resource Science , Wako Saitama 351-0198, Japan.|Chemical Genetics Laboratory, RIKEN , Wako Saitama 351-0198, Japan.
Akihiro
A
Ito
Chemical Genomics Reserach Group, RIKEN Center for Sustainable Resource Science , Wako Saitama 351-0198, Japan.|Chemical Genetics Laboratory, RIKEN , Wako Saitama 351-0198, Japan.
Minoru
M
Yoshida
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo , Bunkyo-ku, Tokyo 113-8657, Japan.
Shigeru
S
Okada
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo , Bunkyo-ku, Tokyo 113-8657, Japan.
Kentaro
K
Takada
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo , Bunkyo-ku, Tokyo 113-8657, Japan.
Shigeki
S
Matsunaga
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D000458:Cyanobacteria / Q000737:chemistry; D003521:Cyclopropanes / Q000737:chemistry / Q000302:isolation & purification*; D004447:Echinodermata / Q000737:chemistry*; D008938:Mitosis / Q000187:drug effects; D015394:Molecular Structure; D013844:Thiazoles / Q000737:chemistry / Q000302:isolation & purification*; D014404:Tubulin / Q000378:metabolism
D000970:Antineoplastic Agents; D003521:Cyclopropanes; D013844:Thiazoles; D014404:Tubulin; C000620417:curacin E; C095843:curacin A