Consumption of Dietary Resistant Starch Partially Corrected the Growth Pattern Despite Hyperglycemia and Compromised Kidney Function in Streptozotocin-Induced Diabetic Rats.
We previously demonstrated that feeding of dietary resistant starch (RS) prior to the induction of diabetes delayed the progression of diabetic nephropathy and maintained vitamin D balance in streptozotocin (STZ)-induced type 1 diabetic (T1D) rats. Here, we examined the impact of RS on kidney function and vitamin D homeostasis following STZ injection. Male Sprague-Dawley rats were administered STZ and fed a standard diet containing cornstarch or 20, 10, or 5% RS for 4 weeks. T1D rats fed 10 and 20% RS, but not 5% RS, gained more weight than cornstarch-fed rats. Yet, renal health and glucose metabolism were not improved by RS. Our data suggest that RS normalized growth patterns in T1D rats after diabetes induction in a dose-dependent manner despite having no effect on blood glucose and vitamin D balances. Future interventions should focus on the preventative strategies with RS in T1D.
The Interdepartmental Graduate Program in Nutritional Sciences and ‡Department of Food Science and Human Nutrition, Iowa State University , Ames, Iowa 50011, United States.
Gar Yee
GY
Koh
The Interdepartmental Graduate Program in Nutritional Sciences and ‡Department of Food Science and Human Nutrition, Iowa State University , Ames, Iowa 50011, United States.
Matthew J
MJ
Rowling
The Interdepartmental Graduate Program in Nutritional Sciences and ‡Department of Food Science and Human Nutrition, Iowa State University , Ames, Iowa 50011, United States.
Kevin L
KL
Schalinske
The Interdepartmental Graduate Program in Nutritional Sciences and ‡Department of Food Science and Human Nutrition, Iowa State University , Ames, Iowa 50011, United States.
Kelly
K
Grapentine
The Interdepartmental Graduate Program in Nutritional Sciences and ‡Department of Food Science and Human Nutrition, Iowa State University , Ames, Iowa 50011, United States.
Yi Ting
YT
Loo
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000178:diet therapy* / Q000503:physiopathology; D003922:Diabetes Mellitus, Type 1 / Q000178:diet therapy; D006943:Hyperglycemia / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D007677:Kidney Function Tests; D008297:Male; D017207:Rats, Sprague-Dawley; D013213:Starch / Q000737:chemistry / Q000494:pharmacology*; D013311:Streptozocin; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014807:Vitamin D / Q000097:blood
D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D014807:Vitamin D; D013311:Streptozocin; D013213:Starch
25-hydroxycholecalciferol; diabetic nephropathy; high-amylose maize; resistant starch; streptozotocin; type 1 diabetes; vitamin D