Rapid and efficient enantioseparation of (S)-amlodipine by surface-imprinted core-shell polymer microspheres.
We present a protocol for the preparation of surface-imprinted polymer microspheres by core-shell precipitation polymerization for the enantioseparation of (S)-amlodipine. In this work, submicron mesoporous silica microspheres were prepared with gemini cationic surfactant as soft template. Molecularly imprinted polymers were coated on the silica supports with a low level of crosslinking, and the thickness of the thin-walled imprinted shell was about 45 nm. The material showed fast binding kinetics for (S)-amlodipine (within only 20 min for complete equilibrium), and the saturation adsorption capacity reached 309.2 mg/g, indicating the good accessibility of binding sites and improved mass transfer for target molecule. The imprinted microspheres exhibited an appreciable enantiomeric excess of (S)-amlodipine of 11.3% when used as a glass chromatography column for the enantioseparation of (S)-amlodipine from amlodipine besylate without extra chiral additives. The surface-imprinted materials display potentially amplification for industrial enantioseparation of (S)-amlodipine.
Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, Hunan, China.|School of Chemical Engineering, Xiangtan University, Xiangtan, Hunan, China.
Shenzhi
S
Lai
Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, Hunan, China.
Chunyan
C
Chen
Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, Hunan, China.
Xiaoli
X
Ouyang
Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, Hunan, China.
Yanru
Y
Qin
Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, Hunan, China.
Changqun
C
Cai
Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, Hunan, China.
Xiaoming
X
Chen
D000327:Adsorption; D017311:Amlodipine / Q000302:isolation & purification*; D008863:Microspheres; D054802:Molecular Imprinting; D058105:Polymerization; D011108:Polymers
D011108:Polymers; D017311:Amlodipine
Amlodipine; Enantioseparation; Fast binding kinetics; Surface-imprinted polymers