Combined Exercise Training Improves Glycemic Control in Adult with Cystic Fibrosis.
Glucose abnormality and diabetes are the most common comorbidities in cystic fibrosis (CF). Combined (aerobic and resistance) exercise program in type 2 patients with diabetes demonstrated an improvement of glycemic control. The aim of the study was to determine whether a combined exercise program is beneficial to improve plasma glucose at 2 h of the oral glucose tolerance test in CF.



Eighteen adults with CF with glucose abnormality were recruited (Clinicaltrial.gov: NTC02127957), and 17 were randomly assigned to a control or exercise group for 12 wk. V˙O2max, oral glucose tolerance test, muscular endurance and strength, and quality of life were measured pre- and postintervention.



Fourteen participants completed the protocol. Patients in the exercise group improved significantly their 2-h plasma glucose values (-2.34 ± 1.26 mmol·L, P < 0.007, confidence interval = 99.22%) and presented a reduction of 17.2% (P < 0.05) in total glucose excursion. No significant change for other parameters was observed.



A combined exercise program improves glycemic control in CF.
1Institut de Recherches Cliniques de Montreal (IRCM), Montreal, Quebec, CANADA; 2Cystic Fibrosis Clinic, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, CANADA; 3Department of Nutrition, Montreal University, Montreal, Quebec, CANADA; and 4Department of Medecine, Montreal University, Montreal, Quebec, CANADA.
Nadia
N
Beaudoin
Guillaume F
GF
Bouvet
Adèle
A
Coriati
Rémi
R
Rabasa-Lhoret
Yves
Y
Berthiaume
D061725:Accelerometry; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D003550:Cystic Fibrosis / Q000150:complications*; D016207:Cytokines / Q000097:blood; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D018149:Glucose Intolerance / Q000097:blood* / Q000150:complications / Q000628:therapy*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D053580:Muscle Strength / Q000502:physiology; D055070:Resistance Training; D055815:Young Adult
D015415:Biomarkers; D001786:Blood Glucose; D016207:Cytokines; D007328:Insulin