Low serum prealbumin levels in post-stroke depression.
Previous studies have shown that prealbumin is associated with depression. However, the association between prealbumin and post-stroke depression remains unelucidated. This observational cohort study determined whether low baseline serum prealbumin could predict post-stroke depression at 1 month in patients admitted with acute stroke. The study, conducted from October 2013 to September 2014, included 307 patients with acute stroke who were followed-up for 1 month. Serum prealbumin was measured within 24h after admission using an immunoturbidimetric method. The17-item Hamilton Depression Scale was used to evaluate depression symptoms. Patients with a depression score of ≥7 were evaluated using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, 4th edition, for diagnosing post-stroke depression at 1 month. Binary logistic regression analysis was used to evaluate possible predictors of post-stroke depression. Overall, 93 (30.3%) patients were diagnosed with post-stroke depression. Serum prealbumin was significantly lower in patients with versus those without post-stroke depression, and was a significant predictor of post-stroke depression after adjusting for confounding risk factors. In conclusion, baseline serum prealbumin level was associated with post-stroke depression at 1 month, suggesting that prealbumin might be a useful biomarker for post-stroke depression.
Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Liping
L
Wang
Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Huiqin
H
Xu
Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Wenwei
W
Ren
Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Lin
L
Zhu
Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yaling
Y
Chang
Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yingying
Y
Gu
Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Mengjiao
M
Yan
Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address: hjc@wmu.edu.cn.
Jincai
J
He
D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D015331:Cohort Studies; D003863:Depression / Q000209:etiology / Q000378:metabolism* / Q000523:psychology; D003866:Depressive Disorder / Q000209:etiology / Q000378:metabolism* / Q000523:psychology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D011228:Prealbumin / Q000378:metabolism*; D012307:Risk Factors; D020521:Stroke / Q000150:complications / Q000378:metabolism* / Q000523:psychology
D015415:Biomarkers; D011228:Prealbumin
Depression; Prealbumin; Stroke