Corrosion resistance of biodegradable Mg with a composite polymer coating.
Degrading Mg and its alloys are a category of implant materials for bone surgery, but rapid corrosion in physiological environment limits their clinical applications. To improve the corrosion resistance of Mg-based implants, a biodegradable composite polymer coating is deposited on an Mg rod in this work. The strategy is to decorate Mg surfaces with poly(γ-glutamic acid)-g-7-amino-4-methylcoumarin/hydroxyapatite (γ-PGA-g-AMC/HAp) composite nanoparticles through electrophoretic deposition in ethanol. The morphology and chemical composition of the resulting coating material are determined by scanning electron microscopy and Fourier transform infrared spectroscopy. Sample rods of bare Mg and coated Mg are implanted intramedullary into the femora of New Zealand white rabbits, periodic radiography and post-autopsy histopathology of each sample are analyzed. The obtained in vivo results clearly conﬁrm that the coating material decreases degradation rate of the underlying Mg sample and appears good histocompatibility and osteoinductivity. The main aim of this work is to investigate the degradation process of bare Mg and coated Mg samples in bone environment and their effect on the surrounding bone tissue.
a Department of Orthopedics , Nanjing Medical University Affiliated Wuxi Second Hospital , Wuxi , People's Republic of China.
Peng
P
Chen
b Key Laboratory of Food Colloids and Biotechnology, Ministry of Education , School of Chemical and Material Engineering, Jiangnan University , Wuxi , People's Republic of China.
Jiadi
J
Sun
b Key Laboratory of Food Colloids and Biotechnology, Ministry of Education , School of Chemical and Material Engineering, Jiangnan University , Wuxi , People's Republic of China.
Ye
Y
Zhu
a Department of Orthopedics , Nanjing Medical University Affiliated Wuxi Second Hospital , Wuxi , People's Republic of China.
Xun
X
Yu
b Key Laboratory of Food Colloids and Biotechnology, Ministry of Education , School of Chemical and Material Engineering, Jiangnan University , Wuxi , People's Republic of China.
Long
L
Meng
b Key Laboratory of Food Colloids and Biotechnology, Ministry of Education , School of Chemical and Material Engineering, Jiangnan University , Wuxi , People's Republic of China.
Yang
Y
Li
b Key Laboratory of Food Colloids and Biotechnology, Ministry of Education , School of Chemical and Material Engineering, Jiangnan University , Wuxi , People's Republic of China.
Xiaoya
X
Liu
D000818:Animals; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000378:metabolism* / Q000633:toxicity; D003343:Corrosion; D003374:Coumarins / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D008274:Magnesium / Q000737:chemistry* / Q000378:metabolism* / Q000633:toxicity; D008297:Male; D053758:Nanoparticles / Q000737:chemistry; D011099:Polyglutamic Acid / Q000737:chemistry*; D019736:Prostheses and Implants; D011817:Rabbits
D020099:Coated Materials, Biocompatible; D003374:Coumarins; D011099:Polyglutamic Acid; D017886:Durapatite; D008274:Magnesium
Anticorrosion; EPD; Mg rod; composite coating; in vivo