Metalloproteases Affecting Blood Coagulation, Fibrinolysis and Platelet Aggregation from Snake Venoms: Definition and Nomenclature of Interaction Sites.
Snake venom metalloproteases, in addition to their contribution to the digestion of the prey, affect various physiological functions by cleaving specific proteins. They exhibit their activities through activation of zymogens of coagulation factors, and precursors of integrins or receptors. Based on their structure-function relationships and mechanism of action, we have defined classification and nomenclature of functional sites of proteases. These metalloproteases are useful as research tools and in diagnosis and treatment of various thrombotic and hemostatic conditions. They also contribute to our understanding of molecular details in the activation of specific factors involved in coagulation, platelet aggregation and matrix biology. This review provides a ready reference for metalloproteases that interfere in blood coagulation, fibrinolysis and platelet aggregation.
Protein Science Laboratory, Department of Biological Sciences, Faculty of Science, 14 Science Drive 4, National University of Singapore, Singapore 117543, Singapore. dbskinim@nus.edu.sg.
R Manjunatha
RM
Kini
Protein Science Laboratory, Department of Biological Sciences, Faculty of Science, 14 Science Drive 4, National University of Singapore, Singapore 117543, Singapore. choyeow@nus.edu.sg.
Cho Yeow
CY
Koh
allosteric sites; anticoagulant; exosites in enzymes; factor X activator; fibrinolytic; platelet aggregation; procoagulant; prothrombin activator
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