Methylation Status of the Serotonin Transporter Promoter CpG Island Is Associated With Major Depressive Disorder in Chinese Han Population: A Case-Control Study.
This study was aimed to investigate the relationship between the methylation status of serotonin transporter (5-HTT) and major depressive disorder (MDD) in Chinese Han population. A total of 96 patients with MDD and 55 healthy volunteers were recruited, and the methylation index (MtI) at six positions in the cytosine-phosphate-guanosine island of 5-HTT gene was measured for each subject using bisulfite pyrosequencing. MtIs at positions 5 and 6 were higher in patients with MDD than those in controls. According to the multivariable logistic regression analysis, MtIs at positions 4 and 5 were significantly associated with MDD. Besides, depression education was an independent risk factor, whereas higher educational levels were protective factors for MDD. In addition, positions 1 and 4 were negatively correlated with weight and diurnal variation. Therefore, 5-HTT methylation might be closely related with MDD in Chinese Han population because of the correlation with diurnal variation and weight.
*Department of Psychiatric and Psychology, the First Affiliated Hospital, Harbin Medical University; †Department of Psychiatric and Psychology, Weifang Mental Health Center; and ‡Department of Psychiatric and Psychology, the Third People's Hospital of Huzhou, China.
Mei
M
Shi
Hongli
H
Sun
Ye
Y
Xu
Zhenhua
Z
Wang
Hongyu
H
Cui
Chengmin
C
Wang
Wei
W
Liu
Ganghui
G
An
Jian
J
Hu
D000328:Adult; D001835:Body Weight / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D002940:Circadian Rhythm / Q000235:genetics*; D018899:CpG Islands; D019175:DNA Methylation / Q000235:genetics*; D003865:Major Depressive Disorder / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011401:Promoter Regions, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D055815:Young Adult
C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins