Hyperpolarized MRS: New tool to study real-time brain function and metabolism.
The advent of dissolution dynamic nuclear polarization (DNP) led to the emergence of a new kind of magnetic resonance (MR) measurements providing the opportunity to probe metabolism in vivo in real time. It has been shown that, following the injection of hyperpolarized substrates prepared using dissolution DNP, specific metabolic bioprobes that can be used to differentiate between healthy and pathological tissue in preclinical and clinical studies can be readily detected by MR thanks to the tremendous signal enhancement. The present article aims at reviewing the studies of cerebral function and metabolism based on the use of hyperpolarized MR. The constraints and future opportunities that this technology could offer are discussed.
Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland. Electronic address: mor.mishkovsky@epfl.ch.
Mor
M
Mishkovsky
General Electric Healthcare, Chalfont St Giles, Buckinghamshire, HP8 4SP, United Kingdom. Electronic address: arnaud.comment@ge.com.
Arnaud
A
Comment
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003287:Contrast Media / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008954:Models, Biological
D003287:Contrast Media
(13)C; Brain uptake; Cerebral metabolism; Dynamic nuclear polarization; MRI; Perfusion imaging