Tibiofemoral Osteoarthritis and Varus-Valgus Laxity.
The purpose of this study was to systematically review and synthesize the literature measuring varus-valgus laxity in individuals with tibiofemoral osteoarthritis (OA). Specifically, we aimed to identify varus-valgus laxity differences between persons with OA and controls, by radiographic disease severity, by frontal plane knee alignment, and by sex. We also aimed to identify if there was a relationship between varus-valgus laxity and clinical performance and self-reported function. We systematically searched for peer-reviewed original research articles in PubMed, Scopus, and CINAHL to identify all existing literature regarding knee OA and objective measurement of varus-valgus laxity in vivo. Forty articles were identified that met the inclusion criteria and data were extracted. Varus-valgus laxity was significantly greater in individuals with OA compared with controls in a majority of studies, while no study found laxity to be significantly greater in controls. Varus-valgus laxity of the knee was reported in persons with OA and varying degrees of frontal plane alignment, disease severity, clinical performance, and self-reported function but no consensus finding could be identified. Females with knee OA appear to have more varus-valgus laxity than males. Meta-analysis was not possible due to the heterogeneity of the subject populations and differences in laxity measurement devices, applied loading, and laxity definitions. Increased varus-valgus laxity is a characteristic of knee joints with OA. Large variances exist in reported varus-valgus laxity and may be due to differences in measurement devices. Prospective studies on joint laxity are needed to identify if increased varus-valgus laxity is a causative factor in OA incidence and progression.
Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, Ohio.|Department of Orthopaedics, The Ohio State University Columbus, Ohio.
Gregory M
GM
Freisinger
School of Health and Rehabilitation Sciences, The Ohio State University, Columbus, Ohio.
Laura C
LC
Schmitt
Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio.
Andrea B
AB
Wanamaker
Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, Ohio.|Department of Orthopaedics, The Ohio State University Columbus, Ohio.|School of Health and Rehabilitation Sciences, The Ohio State University, Columbus, Ohio.|Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio.
Robert A
RA
Siston
Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, Ohio.|Department of Orthopaedics, The Ohio State University Columbus, Ohio.|School of Health and Rehabilitation Sciences, The Ohio State University, Columbus, Ohio.|Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio.
Ajit M W
AMW
Chaudhari
D006801:Humans; D007593:Joint Instability / Q000150:complications / Q000503:physiopathology*; D007719:Knee Joint / Q000503:physiopathology*; D020370:Osteoarthritis, Knee / Q000150:complications / Q000503:physiopathology*
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