Fetal neuroblastoma: ultrasonography and magnetic resonance imaging findings in the prenatal and postnatal IV-S stage.
We report a case of a fetus with an ultrasonography diagnosis of a neuroblastoma during a routine third trimester fetal scan, which presented as a hyperechogenic nodule located above the right kidney. No other abnormalities were found in the ultrasonography scan; however, the follow-up ultrasonography during the 36th week of gestation revealed that the lesion had doubled in size. At the same time, magnetic resonance imaging demonstrated a round mass in the topography of the right adrenal gland with a low signal on T1-weighted images and slightly high signal on T2-weighted images, causing a slight inferior displacement of the kidney. The liver had enlarged and had heterogeneous signal intensity, predominantly hypointense on T2-weighted sequences. Based on these findings, a diagnosis of congenital adrenal neuroblastoma with liver metastases was suggested. A newborn male was delivered by cesarean section 2 weeks later. The physical examination of the neonate revealed abdominal distention and hepatomegaly. The infant had a clinical follow-up in which no surgical or medical intervention was required. At 5 months of age, the infant was asymptomatic with a normal physical examination.
Department of Radiology, Clínica de Diagnóstico por Imagem (CDPI), Rio de Janeiro, Brazil.
Heron
H
Werner
Department of Radiology, Clínica de Diagnóstico por Imagem (CDPI), Rio de Janeiro, Brazil.
Pedro
P
Daltro
Department of Radiology, Clínica de Diagnóstico por Imagem (CDPI), Rio de Janeiro, Brazil.
Taisa
T
Davaus
Department of Obstetrics, Paulista School of Medicine-Federal University of São Paulo (EPM-UNIFESP), São Paulo, Brazil.
Edward
0000-0002-6145-2532
E
Araujo Júnior
Fetus; Magnetic resonance imaging; Neuroblastoma; Prenatal diagnosis; Ultrasonography
Genomics. 1999 Oct 15;61(2):210-8
10534406
Ultrasound Obstet Gynecol. 1997 Jul;10 (1):68-73
9263428
Radiographics. 2004 Oct;24 Suppl 1:S73-86
15486251
J Urol. 2001 Dec;166(6):2375
11696789
Genomics. 2000 Mar 1;64(2):195-202
10729226
J Pediatr Hematol Oncol. 2005 Dec;27(12):670-1
16344674
J Korean Med Sci. 2003 Aug;18(4):618-20
12923347
Radiographics. 2002 Jul-Aug;22(4):911-34
12110723
Radiology. 1990 May;175(2):365-8
2183280
Eur J Cancer. 1999 Apr;35(4):606-11
10492635
Cir Pediatr. 2004 Apr;17(2):89-92
15285592
Br J Radiol. 1998 Nov;71(851):1205-7
10434918
Ultrasound Obstet Gynecol. 2008 Jan;31(1):92-5
18058843