Gambogic Acid and Its Role in Chronic Diseases.
Kokum, a spice derived from the fruit of the Garcinia hanburyi tree, is traditionally used in Ayurvedic medicines to facilitate digestion and to treat sores, dermatitis, diarrhoea, dysentery, and ear infection. One of the major active components of kokum is gambogic acid, also known as guttic acid, guttatic acid, beta-guttilactone, and beta-guttiferin. Gambogic acid's anti-proliferative, anti-bacterial; antioxidant and anti-inflammatory effects result from its modulation of numerous cell-signaling intermediates. This chapter discusses the sources, chemical components, mechanism of action, and disease targets of the kokum spice.
Department of Pharmacology, College of Medicine, Pennsylvania State University, 500 University Dr., Hershey, PA, 17033, USA. mkp13@psu.edu.
Manoj K
MK
Pandey
Department of Pharmacology, College of Medicine, Pennsylvania State University, 500 University Dr., Hershey, PA, 17033, USA.
Deepkamal
D
Karelia
Department of Pharmacology, College of Medicine, Pennsylvania State University, 500 University Dr., Hershey, PA, 17033, USA.
Shantu G
SG
Amin
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D002908:Chronic Disease; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D015398:Signal Transduction / Q000187:drug effects; D044004:Xanthones / Q000494:pharmacology / Q000627:therapeutic use*
D044004:Xanthones; C052659:gambogic acid
Cancer; Dietary agents; Gambogic acid; Kokum; Neutraceuticals; Signal transduction pathways