Prostatic Adenocarcinoma With Hormone Exposure Related Changes in a Patient With Hepatic Cirrhosis - Value of Autopsy in a Case Report.
Hepatic cirrhosis is commonly associated with hyperestrogenism. Previous studies have reported morphologic changes in benign and malignant prostate tissue exposed to estrogen or anti-androgens. To our knowledge, histopathologic features of prostatic adenocarcinoma in patients with cirrhosis have not been well-reported. We present a case of incidental, but pathologically significant, prostatic adenocarcinoma detected on autopsy in a 67-year-old male patient with cirrhosis and spider angiomata. The morphologic and immunohistochemical features (including variable ERG expression) of the prostatic adenocarcinoma were consistent with hormone exposure related changes, suggesting that cirrhosis-induced elevated estrogen-to-testosterone ratio and exogenous hormone therapy might induce similar phenotypes.
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Stephanie L
SL
Skala
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Scott R
SR
Owens
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA; Clinical Cytogenetics Laboratory, Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Hong
H
Xiao
Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USA.
Kristy A
KA
Bauman
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA; Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA.
Scott A
SA
Tomlins
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA; Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA.
Arul M
AM
Chinnaiyan
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA; Clinical Cytogenetics Laboratory, Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Lina
L
Shao
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Jeffrey M
JM
Jentzen
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
David
D
Gordon
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA; Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA.
Rohit
R
Mehra
Anti-androgen; Cirrhosis; ERG; Hormone exposure related changes; Prostatic adenocarcinoma
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