The Use of Adipose-Derived Progenitor Cells and Platelet-Rich Plasma Combination for the Treatment of Supraspinatus Tendinopathy in 55 Dogs: A Retrospective Study.
OBJECTIVE
To report clinical findings and outcomes for 55 dogs with supraspinatus tendinopathy (ST) treated with adipose-derived progenitor cells and platelet-rich plasma (ADPC-PRP) therapy.


METHODS
Medical records of client-owned dogs diagnosed with ST that were treated with ADPC-PRP combination therapy were reviewed from 2006 to 2013. Data collected included signalment, medical history, limb involvement, prior treatments, physical and orthopedic examination, objective temporospatial gait analysis findings, diagnostic imaging results (radiography, magnetic resonance imaging, musculoskeletal ultrasonography), arthroscopy findings, and outcome.


RESULTS
Following ultrasound-guided injection of ADPC-PRP, objective gait analysis was available on 25 of the 55 dogs at 90 days post ADPC-PRP therapy. Following treatment, a significant increase in total pressure index percentage (TPI%) was noted in the injured (treated) forelimb at 90 days post treatment (p = 0.036). At 90 days following treatment, 88% of cases had no significant difference in TPI% of the injured limb to the contralateral limb. The remaining 12% of cases had significantly improved (p = 0.036). Bilateral shoulder diagnostic musculoskeletal ultrasound revealed a significant reduction in tendon size (CSA) in the treated tendon at 90 days following treatment when compared to the initial CSA (p = 0.005). All cases showed significant improvement in fiber pattern of the affected supraspinatus tendon by the ultrasound shoulder pathology rating scale.


CONCLUSIONS
These findings suggest that ADPC-PRP therapy should be considered for dogs with ST.
Veterinary Orthopedic and Sports Medicine , Annapolis Junction, MD , USA.
Sherman O
SO
Canapp
Veterinary Orthopedic and Sports Medicine , Annapolis Junction, MD , USA.
Debra A
DA
Canapp
Regenerative Orthopedic and Sports Medicine , Washington, DC , USA.
Victor
V
Ibrahim
Veterinary Orthopedic and Sports Medicine , Annapolis Junction, MD , USA.
Brittany Jean
BJ
Carr
Veterinary Orthopedic and Sports Medicine , Annapolis Junction, MD , USA.
Catherine
C
Cox
Marion duPont Scott Equine Medical Center, Virginia-Maryland College of Veterinary Medicine, Virginia Tech , Leesburg, VA , USA.
Jennifer G
JG
Barrett
adipose-derived stem cells; mesenchymal stem cells; platelet-rich plasma; regenerative medicine; rotator cuff; supraspinatus tendinopathy
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