[The role of gut microbiota in the regulation of the immune response].
The gastrointestinal tract hosts around 10(14) bacterial microorganisms, in a constantly growing density from the stomach to the distal colon. This microbiota is composed by more than 500 species of bacteria, which are quickly acquired after birth, fairly stable during the hosts life, and essential for human homeostasis. These bacteria have important functions, such as stimulating the immune system, protecting the host from invading bacteria and viruses, and improving digestion, especially of complex carbohydrates. Also, the gut microbiota interacts directly with the immune system. However, the interaction of the intestinal epithelium and its microbiota with the immune system has yet to be fully understood. Secretory immunoglobulin A, produced by the plasma cells in Peyers patches and in the lamina propria, maintains non-invasive commensal bacteria and neutralize invasive pathogens. Dendritic cells migrate from the lamina propria of the secondary lymphoid organs to regulate gut immunity. They also have a key role maintaining luminal IgA and inducing the growth of regulatory T cells. Dendritic cells supervise the gut microenvironment too, keeping an immunological equilibrium and tolerance. The importance of the gut microbiota in regulating the immune system lies mostly in the homeostasis-or positive equilibrium. Thus, many diseases are a consequence of poor interactions or a loss of this equilibrium.
Departamento de Bioquímica Clínica e Inmunología, Facultad de Farmacia, Universidad de Concepción, Chile, pedroalarcon@udec.cl.
Pedro
P
Alarcón
Departamento de Bioquímica Clínica e Inmunología, Facultad de Farmacia, Universidad de Concepción, Chile.
Margarita
M
González
Instituto de Políticas Públicas en Salud, Universidad San Sebastián, Concepción, Chile.
Érica
É
Castro
D003713:Dendritic Cells / Q000276:immunology; D000069196:Gastrointestinal Microbiome / Q000276:immunology*; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D007071:Immunoglobulin A, Secretory / Q000276:immunology; D007413:Intestinal Mucosa / Q000276:immunology*; D019936:Probiotics; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D007071:Immunoglobulin A, Secretory