Early second-trimester plasma levels of NT-proBNP in women who subsequently develop early-onset preeclampsia.
Plasma levels of NT-proBNP are elevated in women with preeclampsia at the time of diagnosis. The objective of this case-control study was to evaluate N-terminal proBNP (NT-proBNP) in maternal plasma as an early second-trimester biomarker for prediction of early-onset preeclampsia. In early second-trimester samples, women who later developed preeclampsia at gestational age 34 wk + 0 or earlier (n = 16) had similar plasma levels of NT-proBNP (median 51.8, range 26.1-131.9 pg/ml) as women with uncomplicated pregnancy outcomes (n = 43) (53.0, 14.9-184.2 pg/ml). The early second-trimester level of NT-proBNP cannot therefore be used as a predictive biomarker of early-onset preeclampsia.
a Department of Women's and Children's Health.
Katja
K
Junus
a Department of Women's and Children's Health.|b Department of Clinical Sciences , Danderyd Hospital, Karolinska Institutet , Stockholm , Sweden and.
Anna-Karin
AK
Wikström
c Department of Medical Sciences , Biochemical Structure and Function, Uppsala University , Uppsala , Sweden.
Anders
A
Larsson
a Department of Women's and Children's Health.
Matts
M
Olovsson
D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second / Q000097:blood*; D016216:Ultrasonography, Prenatal
D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
B-type natriuretic peptide; BNP; biomarker; hypertension; pregnancy