Histone Posttranslational Modifications of CD4⁺ T Cell in Autoimmune Diseases.
The complexity of immune system is tempered by precise regulation to maintain stabilization when exposed to various conditions. A subtle change in gene expression may be magnified when drastic changes are brought about in cellular development and function. Posttranslational modifications (PTMs) timely alter the functional activity of immune system, and work proceeded in these years has begun to throw light upon it. Posttranslational modifications of histone tails have been mentioned in a large scale of biological developments and disease progression, thereby making them a central field to investigate. Conventional assessments of these changes are centered on the transcription factors and cytokines in T cells regulated by variable histone codes to achieve chromatin remodeling, as well as involved in many human diseases, especially autoimmune diseases. We here put forward an essential review of core posttranslational modulations that regulate T cell function and differentiation in the immune system, with a special emphasis on histone modifications in different T helper cell subsets as well as in autoimmune diseases.
Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha 410011, China. okvinci@126.com.
Zijun
Z
Wang
Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha 410011, China. kevinyin1984@aliyun.com.
Heng
H
Yin
Division of Rheumatology & Clinical Immunology, Department of Medicine, University of Hong Kong, Hong Kong, China. cslau@hku.hk.
Chak Sing
CS
Lau
Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha 410011, China. qianlu5860@gmail.com.
Qianjin
Q
Lu
D001327:Autoimmune Diseases / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D009103:Multiple Sclerosis / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D011499:Protein Processing, Post-Translational; D012595:Scleroderma, Systemic / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology / Q000276:immunology / Q000378:metabolism
D006657:Histones
T cell; autoimmune diseases; histone modifications; posttranslational modification (PTM)
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