Circulating CXCL16 in Diabetic Kidney Disease.
OBJECTIVE
Chronic kidney disease and, specifically, diabetic kidney disease, is among the fastest increasing causes of death worldwide. A better understanding of the factors contributing to the high mortality may help design novel monitoring and therapeutic approaches. CXCL16 is both a cholesterol receptor and a chemokine with a potential role in vascular injury and inflammation. We aimed at identifying predictors of circulating CXCL16 levels in diabetic patients with chronic kidney disease.


METHODS
We have now studied plasma CXCL16 in 134 European patients with diabetic kidney disease with estimated glomerular filtration rate (eGFR) categories G1-G4 and albuminuria categories A1-A3, in order to identify factors influencing plasma CXCL16 in this population.


RESULTS
Plasma CXCL16 levels were 4.0±0.9 ng/ml. Plasma CXCL16 increased with increasing eGFR category from G1 to G4 (that is, with decreasing eGFR values) and with increasing albuminuria category. Plasma CXCL16 was higher in patients with prior cardiovascular disease (4.33±1.03 vs 3.88±0.86 ng/ml; p=0.013). In multivariate analysis, eGFR and serum albumin had an independent and significant negative correlation with plasma CXCL16.


CONCLUSIONS
In diabetic kidney disease patients, GFR and serum albumin independently predicted plasma CXCL16 levels.
IIS-Fundación Jiménez Díaz, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.
Usama
U
Elewa
Maria D
MD
Sanchez-Niño
Ignacio
I
Mahillo-Fernández
Catalina
C
Martin-Cleary
Ana
A
Belen Sanz
Maria Vanessa
MV
Perez-Gomez
Beatriz
B
Fernandez-Fernandez
Alberto
A
Ortiz
D000368:Aged; D000419:Albuminuria; D002318:Cardiovascular Diseases; D000075743:Chemokine CXCL16; D019743:Chemokines, CXC / Q000097:blood*; D003928:Diabetic Nephropathies / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D051116:Receptors, Scavenger / Q000097:blood*; D044465:White People
C423727:CXCL16 protein, human; D000075743:Chemokine CXCL16; D019743:Chemokines, CXC; D051116:Receptors, Scavenger