Do Circadian Rhythms Draw the Patterns of Sustained Mental Vigor and Ailment?
Preclinical Research Circadian rhythms are fundamental processes in all cells that coordinate a variety of cellular functions related to a specific time of the day. Disruption of circadian rhythms markedly impacts homeostasis. In this Commentary, we present data that disruption of circadian rhythm may lead to the pathogenesis of neurodegenerative states. In this context, we further argue that there is an urgent need of developing new generations of compounds, chronobiotics, to modulate the molecular substrates of circadian timing system. Chronobiotics conceptually offer an effective way for restoration and protection from the consequences of the circadian disruption. We also briefly discuss whether dysfunctional circadian rhythms are a major driver of aging. Drug Dev Res 77 : 469-473, 2016. © 2016 Wiley Periodicals, Inc.
School of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh, India.
Ashish
A
Sharma
School of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh, India.
Rohit
R
Goyal
D000375:Aging / Q000502:physiology*; D056926:CLOCK Proteins / Q000235:genetics; D002940:Circadian Rhythm / Q000187:drug effects*; D006706:Homeostasis; D006801:Humans; D019636:Neurodegenerative Diseases / Q000188:drug therapy* / Q000235:genetics
D056926:CLOCK Proteins
Alzheimer's disease; aging; chronobiology; neurodegeneration; redox states; suprachiasmatic nucleus