Influenza Research Database: An integrated bioinformatics resource for influenza virus research.
The Influenza Research Database (IRD) is a U.S. National Institute of Allergy and Infectious Diseases (NIAID)-sponsored Bioinformatics Resource Center dedicated to providing bioinformatics support for influenza virus research. IRD facilitates the research and development of vaccines, diagnostics and therapeutics against influenza virus by providing a comprehensive collection of influenza-related data integrated from various sources, a growing suite of analysis and visualization tools for data mining and hypothesis generation, personal workbench spaces for data storage and sharing, and active user community support. Here, we describe the recent improvements in IRD including the use of cloud and high performance computing resources, analysis and visualization of user-provided sequence data with associated metadata, predictions of novel variant proteins, annotations of phenotype-associated sequence markers and their predicted phenotypic effects, hemagglutinin (HA) clade classifications, an automated tool for HA subtype numbering conversion, linkouts to disease event data and the addition of host factor and antiviral drug components. All data and tools are freely available without restriction from the IRD website at https://www.fludb.org.
J. Craig Venter Institute, La Jolla, CA 92037, USA.
Yun
Y
Zhang
J. Craig Venter Institute, La Jolla, CA 92037, USA.
Brian D
BD
Aevermann
Virus and Prion Research Unit, National Animal Disease Center, USDA-ARS, Ames, IA 50010, USA.
Tavis K
TK
Anderson
Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, UK.
David F
DF
Burke
Animal Health Service, Food and Agriculture Organization of the United Nations, Rome 00153, Italy.
Gwenaelle
G
Dauphin
Northrop Grumman Health Solutions, Rockville, MD 20850, USA.
Zhiping
Z
Gu
Northrop Grumman Health Solutions, Rockville, MD 20850, USA.
Sherry
S
He
Northrop Grumman Health Solutions, Rockville, MD 20850, USA.
Sanjeev
S
Kumar
Vecna Technologies, Greenbelt, MD 20770, USA.
Christopher N
CN
Larsen
J. Craig Venter Institute, La Jolla, CA 92037, USA.
Alexandra J
AJ
Lee
Northrop Grumman Health Solutions, Rockville, MD 20850, USA.
Xiaomei
X
Li
Bioinformatics Institute, University of Auckland, Auckland 1010, New Zealand.
Catherine
C
Macken
Northrop Grumman Health Solutions, Rockville, MD 20850, USA.
Colin
C
Mahaffey
J. Craig Venter Institute, La Jolla, CA 92037, USA.
Brett E
BE
Pickett
J. Craig Venter Institute, La Jolla, CA 92037, USA.
Brian
B
Reardon
Northrop Grumman Health Solutions, Rockville, MD 20850, USA.
Thomas
T
Smith
J. Craig Venter Institute, La Jolla, CA 92037, USA.
Lucy
L
Stewart
Northrop Grumman Health Solutions, Rockville, MD 20850, USA.
Christian
C
Suloway
Vecna Technologies, Greenbelt, MD 20770, USA.
Guangyu
G
Sun
Northrop Grumman Health Solutions, Rockville, MD 20850, USA.
Lei
L
Tong
Virus and Prion Research Unit, National Animal Disease Center, USDA-ARS, Ames, IA 50010, USA.
Amy L
AL
Vincent
Northrop Grumman Health Solutions, Rockville, MD 20850, USA.
Bryan
B
Walters
Northrop Grumman Health Solutions, Rockville, MD 20850, USA.
Sam
S
Zaremba
Northrop Grumman Health Solutions, Rockville, MD 20850, USA.
Hongtao
H
Zhao
Northrop Grumman Health Solutions, Rockville, MD 20850, USA.
Liwei
L
Zhou
J. Craig Venter Institute, La Jolla, CA 92037, USA.
Christian
C
Zmasek
Northrop Grumman Health Solutions, Rockville, MD 20850, USA.
Edward B
EB
Klem
J. Craig Venter Institute, La Jolla, CA 92037, USA rscheuermann@jcvi.org.|Department of Pathology, University of California, San Diego, CA 92093, USA.|Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
Richard H
RH
Scheuermann
D019295:Computational Biology / Q000379:methods*; D016208:Databases, Factual; D009980:Influenza A virus / Q000145:classification / Q000502:physiology; D058889:Molecular Typing / Q000379:methods; D010641:Phenotype; D010802:Phylogeny; D012106:Research; D012984:Software; D014764:Viral Proteins / Q000235:genetics; D014774:Virulence
D014764:Viral Proteins
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