Effect of Oxidative Stress in Hemodialysed Patients.
Markers of oxidative stress and inflammatory activation of endothelium, as well as the adipose tissue secreted adipokines, e.g. adiponectin show altered pattern in renal failure. However, their internal relations have not been fully evaluated in this special patient population. In our cross sectional study, beside the routine clinical and biochemical parameters, plasma malondialdehyde, glutathione (GSH), catalase, total peroxidase, as well as serum E-selectin and adiponectin were measured in 70 hemodialysed (HD) patients.


RESULTS
GSH showed negative correlations with systolic and diastolic blood pressure (BP) values, while a positive one with HDL-cholesterol level, as expected. Interestingly, the level of sE-selectin was inversely correlated only with the age. In multiple regression analyses where anthropometric, BP and laboratory parameters were included and sE-selectin was the dependent variable, the inverse association between the age and level of sE-Selectin turned out being an independent factor.


CONCLUSIONS
In HD kidney failure patients of the biochemical cardiovascular risk markers those related to oxidative stress, endothelial dysfunction, or altered adipokine homeostasis are not necessarily strongly associated. Larger studies may be needed to confirm our novel observation, a negative and independent correlation of age to sE-Selectin level.
Institute of Laboratory Medicine, School of Medicine, University of Pecs , Pecs, Hungary.
Attila
A
Peti
FMC Dialysis Center , Pecs, Hungary.
Botond
B
Csiky
FMC Dialysis Center , Pecs, Hungary.
Eszter
E
Guth
1st Department of Medicine, School of Medicine, University of Pecs , Hungary.
Peter
P
Kenyeres
1st Department of Medicine, School of Medicine, University of Pecs , Hungary.
Emese
E
Mezosi
Institute of Laboratory Medicine, School of Medicine, University of Pecs , Pecs, Hungary.
Gabor L
GL
Kovacs
1st Department of Medicine, School of Medicine, University of Pecs , Hungary.
Laszlo
L
Bajnok
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