Downregulation of lysosomal and further gene expression characterization in lung cancer patients with bone metastasis.
Molecular and functional mechanisms of bone metastases were poorly understood. This study was to screen out differentially expressed genes (DEGs) and functional proteins in bone metastases from lung for better understanding of the molecular and functional mechanisms. Our results suggested CTSS, CTSD, MX1, NKX2-1 might play a decisive role in bone metastasis. Collectively, these results demonstrated that bone metastasis from lung cancer would lead to changes in lysosome function, which may affect the decomposition and elimination of old bone matrix, thus affecting bone turnover. In addition, our findings provided new insights into the prediction and treatment of bone metastases.
a Department of Orthopedics , Third Military Medical University Xinqiao Hospital , Chong Qing , China.
Yong
Y
Huang
a Department of Orthopedics , Third Military Medical University Xinqiao Hospital , Chong Qing , China.
Tongwei
T
Chu
a Department of Orthopedics , Third Military Medical University Xinqiao Hospital , Chong Qing , China.
Tongquan
T
Liao
a Department of Orthopedics , Third Military Medical University Xinqiao Hospital , Chong Qing , China.
Xu
X
Hu
a Department of Orthopedics , Third Military Medical University Xinqiao Hospital , Chong Qing , China.
Bo
B
Huang
D001859:Bone Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000556:secondary*; D019295:Computational Biology; D015536:Down-Regulation; D020869:Gene Expression Profiling; D063990:Gene Ontology; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008247:Lysosomes / Q000235:genetics; D025941:Protein Interaction Mapping
Bone metastases; lung cancer; protein–protein interaction network