Withdrawn/Depressed Behaviors and Error-Related Brain Activity in Youth With Obsessive-Compulsive Disorder.
The pathophysiology of obsessive-compulsive disorder (OCD) involves increased activity in corticostriatal circuits connecting the anterior cingulate cortex with other brain regions. The error-related negativity (ERN) is a negative deflection in the event-related potential after an incorrect response that is believed to reflect anterior cingulate cortex activity. This study examined the relation of the ERN to OCD symptom dimensions and other childhood symptom dimensions.



The ERN, correct response negativity, and accuracy were measured during a flanker task to assess performance monitoring in 80 youth with a lifetime diagnosis of OCD and 80 matched healthy comparison participants ranging from 8 to 18 years old. The relation of the ERN to OCD symptom dimension scores and Child Behavior Checklist Syndrome Scale scores was examined in multiple linear regression analyses.



Accuracy was significantly decreased and ERN amplitude was significantly increased in patients compared with controls. ERN amplitude in patients was significantly correlated with accuracy, but not with OCD symptom dimensions, severity, comorbidity, or treatment. In a multiple linear regression analysis using age, accuracy, OCD, and Child Behavior Checklist Syndrome Scale scores as predictors of ERN amplitude, the ERN had significant associations only with Withdrawn/Depressed Scale scores and accuracy.



An enlarged ERN is a neural correlate of pediatric OCD that is independent of OCD symptom expression and severity. The finding of lower accuracy in pediatric cases requires replication. The relation between an enhanced ERN and withdrawn/depressed behaviors warrants further research in youth with OCD and other internalizing disorders.
University of Michigan, Ann Arbor. Electronic address: ghanna@med.umich.edu.
Gregory L
GL
Hanna
University of Michigan, Ann Arbor.
Yanni
Y
Liu
University of Michigan, Ann Arbor.
Yona E
YE
Isaacs
University of Michigan, Ann Arbor.
Angela M
AM
Ayoub
University of Michigan, Ann Arbor.
Jose J
JJ
Torres
Wayne State University School of Medicine, Detroit.
Nolan B
NB
O'Hara
University of Michigan, Ann Arbor.
William J
WJ
Gehring
D000293:Adolescent; D001921:Brain / Q000503:physiopathology; D002648:Child; D003863:Depression / Q000503:physiopathology* / Q000523:psychology*; D004569:Electroencephalography / Q000379:methods; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology*; D011597:Psychomotor Performance / Q000502:physiology; D011930:Reaction Time / Q000502:physiology
Child Behavior Checklist; biomarker; error-related negativity; obsessive-compulsive disorder; symptom dimensions
Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jan 15;35(1):265-72
21111024
Psychophysiology. 2008 Jul;45(4):524-34
18503487
Arch Gen Psychiatry. 2005 Jun;62(6):593-602
15939837
J Abnorm Psychol. 2015 May;124(2):266-74
25643204
Compr Psychiatry. 1987 Jul-Aug;28(4):334-43
3608467
Trends Cogn Sci. 2012 Jan;16(1):43-51
22138231
Am J Psychiatry. 2015 Jul;172(7):665-73
25783756
Electroencephalogr Clin Neurophysiol. 1983 Apr;55(4):468-84
6187540
J Child Psychol Psychiatry. 2006 Feb;47(2):160-6
16423147
Mol Psychiatry. 2007 Oct;12(10):886-90
17895920
Int J Psychophysiol. 2015 Nov;98 (2 Pt 2):276-299
25746725
J Child Psychol Psychiatry. 2004 May;45(4):874-83
15056317
Psychophysiology. 2016 Mar;53(3):372-85
26877129
Psychophysiology. 2010 Sep;47(5):913-20
20230510
J Abnorm Psychol. 2014 Nov;123(4):705-14
25286372
J Am Acad Child Adolesc Psychiatry. 2012 Sep;51(9):902-10
22917203
Eur Arch Psychiatry Clin Neurosci. 2014 Dec;264(8):707-17
24676800
Mol Psychiatry. 2010 Jan;15(1):53-63
18725912
Psychopharmacol Bull. 1985;21(4):995-8
4089116
Neurosci Biobehav Rev. 2014 Oct;46 Pt 1:124-38
24747486
Hum Brain Mapp. 2014 Apr;35(4):1143-53
23418104
J Am Acad Child Adolesc Psychiatry. 1997 Jul;36(7):980-8
9204677
Behav Genet. 2008 Sep;38(5):447-61
18548343
Depress Anxiety. 2013 Jan;30(1):39-46
23225541
J Am Acad Child Adolesc Psychiatry. 1997 Jun;36(6):844-52
9183141
J Am Acad Child Adolesc Psychiatry. 2014 Apr;53(4):447-55
24655654
Psychol Sci. 2000 Jan;11(1):1-6
11228836
Behav Genet. 2010 Jul;40(4):505-17
20361247
Neuropsychologia. 2008;46(7):1877-87
18514679
Biol Psychol. 2010 May;84(2):257-63
20152879
J Am Acad Child Adolesc Psychiatry. 1995 Jan;34(1):19-27
7860451
Am J Psychiatry. 2011 Mar;168(3):317-24
21123314
Am J Psychiatry. 2008 Jan;165(1):116-23
17986681
Br J Psychiatry. 1999 Nov;175:444-51
10789276
Electroencephalogr Clin Neurophysiol. 1991 Jun;78(6):447-55
1712280