Scalable Production of Sensor Arrays Based on High-Mobility Hybrid Graphene Field Effect Transistors.
We have developed a scalable fabrication process for the production of DNA biosensors based on gold nanoparticle-decorated graphene field effect transistors (AuNP-Gr-FETs), where monodisperse AuNPs are created through physical vapor deposition followed by thermal annealing. The FETs are created in a four-probe configuration, using an optimized bilayer photolithography process that yields chemically clean devices, as confirmed by XPS and AFM, with high carrier mobility (3590 ± 710 cm2/V·s) and low unintended doping (Dirac voltages of 9.4 ± 2.7 V). The AuNP-Gr-FETs were readily functionalized with thiolated probe DNA to yield DNA biosensors with a detection limit of 1 nM and high specificity against noncomplementary DNA. Our work provides a pathway toward the scalable fabrication of high-performance AuNP-Gr-FET devices for label-free nucleic acid testing in a realistic clinical setting.
Department of Chemical and Biomolecular Engineering, Hong Kong University of Science and Technology , Clear Water Bay, Kowloon, Hong Kong.
Zhaoli
Z
Gao
Department of Physics and Astronomy, Seoul National University , Seoul 151-747, Republic of Korea.
Hojin
H
Kang
Carl H
CH
Naylor
Frank
F
Streller
Pedro
P
Ducos
Madeline D
MD
Serrano
Jinglei
J
Ping
Jonathan
J
Zauberman
CSIR-National Physical Laboratory , Dr. K. S. Krishnan Road, New Delhi 110012, India.
Rajesh
Robert W
RW
Carpick
School of Materials Science and Engineering, South China University of Technology , Guangzhou 510006, P.R. China.
Ying-Jun
YJ
Wang
Department of Physics and Astronomy, Seoul National University , Seoul 151-747, Republic of Korea.
Yung Woo
YW
Park
Department of Chemical and Biomolecular Engineering, Hong Kong University of Science and Technology , Clear Water Bay, Kowloon, Hong Kong.
Zhengtang
Z
Luo
School of Materials Science and Engineering, South China University of Technology , Guangzhou 510006, P.R. China.
Li
L
Ren
A T Charlie
ATC
Johnson
DNA biosensor; bilayer photolithography process; gold nanoparticles; graphene; scalable fabrication