[Hypoxemia and Osteoporosis-Possible roles of HIF1α on Respiratory disease-related Osteoporosis-.]
Osteoporosis is a disease characterized by increased risks for bone fragility fractures, and is caused by various factors such as aging and menopause. Increase in the number of osteoporosis patients becomes a big concern in the developed countries. Recently, the mechanisms underlying postmenopausal osteoporosis development were being clarified, and several diseases such as respiratory diseases and diabetes were reportedly caused secondary osteoporosis. HIF1α was demonstrated required for osteoclast activation and bone loss in postmenopausal osteoporosis women. However, the roles of HIF1α on respiratory disease-related osteoporosis development remained to be elucidated.
Department of Orthopaedic Surgey, Keio University School of Medice, Japan.
Takeshi
T
Miyamoto
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism*; D050723:Fractures, Bone / Q000150:complications*; D006801:Humans; D000860:Hypoxia; D010010:Osteoclasts / Q000378:metabolism*; D010024:Osteoporosis / Q000209:etiology* / Q000378:metabolism; D012307:Risk Factors; D000099162:Endothelial PAS Domain-Containing Protein 1
D051792:Basic Helix-Loop-Helix Proteins; D000099162:Endothelial PAS Domain-Containing Protein 1