Biomarkers for colitis-associated colorectal cancer.
Patients with extensive ulcerative colitis (UC) of more than eight years duration have an increased risk of colorectal cancer. Molecular biomarkers for dysplasia and cancer could have a great clinical value in managing cancer risk in these UC patients. Using a wide range of molecular techniques - including cutting-edge OMICS technologies - recent studies have identified clinically relevant biomarker candidates from a variety of biosamples, including colonic biopsies, blood, stool, and urine. While the challenge remains to validate these candidate biomarkers in multi-center studies and with larger patient cohorts, it is certain that accurate biomarkers of colitis-associated neoplasia would improve clinical management of neoplastic risk in UC patients. This review highlights the ongoing avenues of research in biomarker development for colitis-associated colorectal cancer.
Ru Chen, Lisa A Lai, Teresa A Brentnall, Sheng Pan, Department of Medicine, University of Washington, Seattle, WA 98195, United States.
Ru
R
Chen
Ru Chen, Lisa A Lai, Teresa A Brentnall, Sheng Pan, Department of Medicine, University of Washington, Seattle, WA 98195, United States.
Lisa A
LA
Lai
Ru Chen, Lisa A Lai, Teresa A Brentnall, Sheng Pan, Department of Medicine, University of Washington, Seattle, WA 98195, United States.
Teresa A
TA
Brentnall
Ru Chen, Lisa A Lai, Teresa A Brentnall, Sheng Pan, Department of Medicine, University of Washington, Seattle, WA 98195, United States.
Sheng
S
Pan
D014408:Biomarkers, Tumor / Q000032:analysis*; D001706:Biopsy; D003093:Colitis, Ulcerative / Q000175:diagnosis* / Q000473:pathology; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D019175:DNA Methylation; D018450:Disease Progression; D006801:Humans; D035683:MicroRNAs / Q000032:analysis; D011230:Precancerous Conditions / Q000473:pathology; D012307:Risk Factors
D014408:Biomarkers, Tumor; D035683:MicroRNAs
Biomarker; Colitis; Colorectal cancer; Dysplasia; Non-progressor; Progressor; Surveillance
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