Cord blood erythropoietin and cord blood nucleated red blood cells for prediction of adverse neonatal outcome associated with maternal obesity in term pregnancy: prospective cohort study.
OBJECTIVE
To determine the adverse pregnancy outcomes associated with maternal pre-pregnancy overweight and obesity and we measure cord blood erythropoietin and NRBC count as indices of hypoxia and predictors of neonatal outcome.


METHODS
This prospective cohort study was done in Minia University Hospital, carried out from May 2015 to April 2016. Two hundred and seventy full-term neonates born to mothers of various body mass indices were included. Excluded were neonates with major factors known to be associated with a potential increase in fetal erythropoiesis. Pre-pregnancy maternal BMI was calculated from maternally reported weight and height. Cord blood erythropoietin and nucleated red blood cells were measured.


RESULTS
There is a significant increase of various adverse pregnancy outcomes as cesarean section. Postpartum hemorrhage and macrosomia with the increase of maternal pre-pregnancy BMI. Significant positive correlations between cord blood erythropoietin and nucleated red blood cells with maternal BMI.


CONCLUSIONS
The increase in the maternal pre-pregnancy BMI is associated with poor pregnancy outcomes. Cord blood erythropoietin and nucleated red blood cells can predict the poor neonatal outcome.
a Department of Obstetrics and Gynecology , Minia University Hospital , El-Minia , Egypt.
Mahmoud H
MH
Ibrahim
b Department of Pediatrics , Minia University Hospital , El-Minia , Egypt.
Asmaa N
AN
Moustafa
c Department of Clinical Pathology , Minia University Hospital , El-Minia , Egypt , and.
Ahmed A Fadil
AAF
Saedii
d Department of Public Health and Preventive Medicine , Minia University Hospital , El-Minia , Egypt.
Ebtesam E
EE
Hassan
D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D002585:Cesarean Section / Q000706:statistics & numerical data; D004900:Erythroblasts / Q000473:pathology*; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D005312:Fetal Blood; D006801:Humans; D007231:Infant, Newborn; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D011446:Prospective Studies; D012372:ROC Curve
C554270:EPO protein, human; D004921:Erythropoietin
Maternal obesity; erythropoietin; nucleated red blood cells