Morvan's syndrome with anti contactin associated protein like 2 - voltage gated potassium channel antibody presenting with syndrome of inappropriate antidiuretic hormone secretion.
Morvan's syndrome is a rare autoimmune disorder characterized by triad of peripheral nerve hyperexcitability, autonomic dysfunction, and central nervous system symptoms. Antibodies against contactin-associated protein-like 2 (CASPR2), a subtype of voltage-gated potassium channel (VGKC) complex, are found in a significant proportion of patients with Morvan's syndrome and are thought to play a key role in peripheral as well as central clinical manifestations. We report a patient of Morvan's syndrome with positive CASPR2-anti-VGKC antibody having syndrome of inappropriate antidiuretic hormone as a cause of persistent hyponatremia.
Department of Neurology, Sawai ManSingh Medical College, Jaipur, Rajasthan, India.
Anjani Kumar
AK
Sharma
Department of Neurology, Sawai ManSingh Medical College, Jaipur, Rajasthan, India.
Manminder
M
Kaur
Department of Neurology, Sawai ManSingh Medical College, Jaipur, Rajasthan, India.
Madhuparna
M
Paul
Anti-voltage-gated potassium channel antibodies; Morvan's syndrome; hyponatremia; myokymia; syndrome of inappropriate antidiuretic hormone
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