DNA damage responses and stress resistance: Concepts from bacterial SOS to metazoan immunity.
The critical need for species preservation has driven the evolution of mechanisms that integrate stress signals from both exogenous and endogenous sources. Past research has been largely focused on cell-autonomous stress responses; however, recently their systemic outcomes within an organism and their implications at the ecological and species levels have emerged. Maintenance of species depends on the high fidelity transmission of the genome over infinite generations; thus, many pathways exist to monitor and restore the integrity of the genome and to coordinate DNA repair with other cellular processes, such as cell division and growth. The specifics of these DNA damage responses (DDRs) vary vastly but some general themes are conserved from ancient organisms, such as bacteria and archaea, to humans. Despite decades of research, however, DDRs still have many layers of complexity and some surprises left to be discovered. One of the most interesting current research topics is the link between DNA damage and stress resistance: the outcomes of DDRs can protect the organism from other secondary challenges. At this time, these types of responses are best characterized in bacteria and the simple metazoan model, Caenorhabditis elegans, but it is becoming clear that similar processes also exist in higher organisms.
Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC) and Systems Biology of Ageing Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany. Electronic address: awilliam@uni-koeln.de.
Ashley B
AB
Williams
Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC) and Systems Biology of Ageing Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany. Electronic address: bjoern.schumacher@uni-koeln.de.
Björn
B
Schumacher
D000818:Animals; D001105:Archaea / Q000235:genetics / Q000378:metabolism; D001419:Bacteria / Q000235:genetics / Q000378:metabolism; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism; D004249:DNA Damage; D006801:Humans; D013014:SOS Response, Genetics / Q000502:physiology*
Caenorhabditis elegans; DNA damage response; Escherichia coli; Immunity; SOS response
Nature. 2010 Feb 25;463(7284):1092-5
20182512
FEMS Microbiol Rev. 2007 Nov;31(6):637-56
17883408
Bacteriol Rev. 1976 Dec;40(4):869-907
795416
Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13991-6
9391140
Proc Biol Sci. 2015 Oct 7;282(1816):20150885
26446807
Nat Commun. 2013;4:2267
23925298
PLoS Genet. 2014 Dec 04;10(12):e1004829
25474470
PLoS Pathog. 2011 Dec;7(12):e1002453
22216003
Semin Immunol. 2014 Aug;26(4):303-9
24856329
Nature. 2012 Sep 13;489(7415):263-8
22922647
PLoS Biol. 2010 Feb 23;8(2):e1000317
20186264
PLoS Genet. 2006 Nov 10;2(11):e183
17096597
FEBS Lett. 2012 Jul 30;586(16):2529-34
22728134
Science. 2003 Jun 20;300(5627):1921
12817143
Nature. 2013 Sep 19;501(7467):416-20
23975097
Cell Metab. 2012 Apr 4;15(4):439-50
22482727
Cell. 2005 Feb 11;120(3):357-68
15707894
Curr Biol. 2001 Oct 30;11(21):1722-7
11696333
Dev Cell. 2014 Dec 22;31(6):722-33
25499914
J Gerontol. 1988 Sep;43(5):B137-41
3418030
Nature. 2000 Jan 13;403(6766):159-64
10646593
PLoS Biol. 2010 Aug 31;8(8):null
20824162
PLoS Genet. 2010 May 06;6(5):e1000941
20463888
Hum Genet. 1982;60(2):101-21
7042533
Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12072-7
11593017
PLoS Genet. 2009 Dec;5(12):e1000760
20011100
Nat Commun. 2014 Sep 11;5:4879
25209682
Nature. 1999 May 27;399(6734):362-6
10360574
Genes Dev. 1994 Jan;8(2):160-73
8299936
J Clin Invest. 2012 Jul;122(7):2601-12
22706308
Curr Opin Cell Biol. 2007 Apr;19(2):238-45
17303408
Development. 1995 Aug;121(8):2525-35
7671816
Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92
9293187
Nat Genet. 2001 Jun;28(2):139-45
11381260
Genetics. 2011 Apr;187(4):1235-40
21288877
PLoS Biol. 2005 Jul;3(7):e255
16000023
Mol Microbiol. 2006 Dec;62(5):1228-38
17042786
Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16275-80
16251270
FEMS Microbiol Rev. 2014 Nov;38(6):1126-45
24923554
Science. 2002 Jul 26;297(5581):623-6
12142542
Trends Microbiol. 2004 Jun;12(6):288-95
15165607
PLoS Genet. 2009 Sep;5(9):e1000639
19749979
Cell Death Differ. 2012 Nov;19(11):1847-55
22705849
Curr Biol. 2002 Nov 19;12(22):1908-18
12445383
PLoS Genet. 2012 Jun;8(6):e1002800
22761594
Nature. 2007 May 31;447(7144):545-9
17538612
Nat Cell Biol. 2014 Dec;16(12 ):1168-1179
25419847
Basic Life Sci. 1975;5A:355-67
1103845
Curr Biol. 2004 Jul 27;14(14):1256-61
15268855
Cell Death Differ. 2007 Jun;14(6):1129-38
17347667
Cell. 2006 Mar 10;124(5):1055-68
16530050
PLoS Genet. 2011 Aug;7(8):e1002238
21901106
Proc Natl Acad Sci U S A. 2016 May 17;113(20):E2832-41
27140632
Cell Death Differ. 2005 Feb;12(2):153-61
15605074
Science. 2001 Oct 19;294(5542):591-5
11557844
Curr Biol. 2011 Sep 27;21(18):1507-14
21906946
Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5014-9
17360327
Mol Cell. 2000 Mar;5(3):435-43
10882129
WormBook. 2005 Aug 15;:1-14
18050413
Genes Dev. 2012 Oct 15;26(20):2311-24
23019125
Trends Genet. 2014 Mar;30(3):95-102
24439457
Nat Commun. 2014 Jun 24;2:4172
24960204
Curr Biol. 2012 Sep 25;22(18):R792-3
23017989
PLoS Biol. 2011 Mar;9(3):e1000599
21423649
Curr Biol. 2003 May 13;13(10 ):819-27
12747829