Potential usefulness of apolipoprotein A2 isoforms for screening and risk stratification of pancreatic cancer.
Given the low incidence of pancreatic cancer in the general population, screening of pancreatic cancer in the general population using invasive modalities is not feasible. Combination of invasive screening with noninvasive biomarkers for pancreatic cancer and its precancerous lesions has the potential to reduce mortality due to pancreatic cancer. In this review, we focus on biomarkers found in the blood that can indicate early-stage pancreatic cancer, and we discuss current strategies for screening for pancreatic cancer. We recently identified a unique alteration in apolipoprotein A2 isoforms in pancreatic cancer and its precancerous lesions, and we describe its clinical usefulness as a potential biomarker for the early detection and risk stratification of pancreatic cancer.
Division of Chemotherapy & Clinical Research, National Cancer Center Research Institute, Tokyo 104-0045, Japan.|Japan Agency for Medical Research & Development (AMED) CREST, Tokyo 100-0004, Japan.
Kazufumi
K
Honda
Division of Cancer Prevention, National Cancer Institute, Rockville, MD 20852, USA.
Sudhir
S
Srivastava
D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood; D016633:Apolipoprotein A-II / Q000097:blood*; D019540:Area Under Curve; D014408:Biomarkers, Tumor / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood; D055088:Early Detection of Cancer; D006801:Humans; D010190:Pancreatic Neoplasms / Q000175:diagnosis*; D020033:Protein Isoforms / Q000097:blood; D012372:ROC Curve; D012307:Risk Factors
D015295:Antigens, Tumor-Associated, Carbohydrate; D016633:Apolipoprotein A-II; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D020033:Protein Isoforms; C578959:carbohydrate antigen 199, human
NCI EDRN; National Cancer Institute Early Detection Research Network; apolipoprotein A2 isoforms; early detection for pancreatic cancer; plasma/serum biomarker
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