Clinical observation of lymphocyte active immunotherapy in 380 patients with unexplained recurrent spontaneous abortion.
OBJECTIVE
This study aims to investigate the clinical curative effect of lymphocyte active immunotherapy (LAI) on unexplained recurrent spontaneous abortion (RSA).


METHODS
A total of 749 RSA patients who received medical service in our hospital from October 2009 to June 2013 were enrolled into this study. These patients were randomly divided into two groups: LAI group (treatment group) and routine progesterone for maintenance tocolysis group (control group). A comparative analysis on the pregnancy outcomes in these two groups was conducted.


RESULTS
Abortion rate was significantly lower in the LAI group than in the control group (P<0.05). Furthermore, pregnancy success rates were 89.7% and 32.2% in patients who received LAI and routine progesterone for maintenance tocolysis, respectively, and the difference was statistically significant (P<0.05).


CONCLUSIONS
Our analysis suggested that LAI can treat RSA effectively and has an excellent clinical effect. Furthermore, the detection of blocking antibodies showed a positive prediction on pregnancy outcome.
Department of Reproductive Medicine, Reproductive Medical Center, The Center Hospital of Nanyang, Nanyang 473009, China. Electronic address: jianlingchendoc@163.com.
Jian-Ling
JL
Chen
Department of Obstetrics and Gynecology, Reproductive Medical Center, The Center Hospital of Nanyang, Nanyang 473009, China.
Jian-Ming
JM
Yang
Department of Reproductive Medicine, Reproductive Medical Center, The Center Hospital of Nanyang, Nanyang 473009, China.
Ya-Zhe
YZ
Huang
Department of Reproductive Medicine, Reproductive Medical Center, The Center Hospital of Nanyang, Nanyang 473009, China.
Ying
Y
Li
D000022:Abortion, Spontaneous / Q000276:immunology / Q000628:therapy*; D000328:Adult; D019138:Antibodies, Blocking / Q000097:blood; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007518:Isoantibodies / Q000097:blood; D017710:Lymphocyte Transfusion; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D012008:Recurrence; D055815:Young Adult
D019138:Antibodies, Blocking; D007518:Isoantibodies
Active immunotherapy; Blocking antibody; Recurrent miscarriage