neo-Clerodane Diterpenoids and Other Constituents of Salvia filipes.
A series of neo-clerodane-type diterpenoids were isolated from the aerial parts of Salvia filipes, including the new compounds 4-epi-polystachyne A (1), salvifilines A (3), C (7), and D (8), and salvifiline B, which was isolated as the 15-O-methyl derivatives 4/5. In addition, the five known diterpenoids (2, 9-12), together with ursolic, oleanolic, and betulinic acids, and the flavone eupatorin were also isolated. The structures were determined by analysis of their spectroscopic data, mainly 1D and 2D NMR. The structure of salvifiline D was confirmed by X-ray analysis. The cytotoxic activities of the diterpenoids were evaluated, but all were inactive against a panel of six human cancer cell lines.
Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria , Coyoacán, 04510, D.F., México.
Emma
E
Maldonado
Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria , Coyoacán, 04510, D.F., México.
Leonel
L
Galicia
Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria , Coyoacán, 04510, D.F., México.
Ma Isabel
MI
Chávez
Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria , Coyoacán, 04510, D.F., México.
Simón
S
Hernández-Ortega
D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008800:Mexico; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D053978:Pentacyclic Triterpenes; D035261:Plant Components, Aerial / Q000737:chemistry; D027544:Salvia / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry; D000094062:Betulinic Acid
D045785:Diterpenes, Clerodane; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; D000094062:Betulinic Acid