Secretagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneurons.
Corticostriatal afferents can engage parvalbumin-expressing (PV+) interneurons to rapidly curtail the activity of striatal projection neurons (SPNs), thus shaping striatal output. Schemes of basal ganglia circuit dynamics generally consider striatal PV+ interneurons to be homogenous, despite considerable heterogeneity in both form and function. We demonstrate that the selective co-expression of another calcium-binding protein, secretagogin (Scgn), separates PV+ interneurons in rat and primate striatum into two topographically-, physiologically- and structurally-distinct cell populations. In rats, these two interneuron populations differed in their firing rates, patterns and relationships with cortical oscillations in vivo. Moreover, the axons of identified PV+/Scgn+ interneurons preferentially targeted the somata of SPNs of the so-called 'direct pathway', whereas PV+/Scgn- interneurons preferentially targeted 'indirect pathway' SPNs. These two populations of interneurons could therefore provide a substrate through which either of the striatal output pathways can be rapidly and selectively inhibited to subsequently mediate the expression of behavioral routines.
Medical Research Council Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Oxford, United Kingdom.
Farid N
FN
Garas
Medical Research Council Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Oxford, United Kingdom.
Rahul S
0000-0002-8616-8693
RS
Shah
Medical Research Council Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Oxford, United Kingdom.
Eszter
E
Kormann
Medical Research Council Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Oxford, United Kingdom.
Natalie M
0000-0001-6821-0264
NM
Doig
Medical Research Council Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Oxford, United Kingdom.
Federica
F
Vinciati
Medical Research Council Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Oxford, United Kingdom.
Kouichi C
0000-0001-7053-0507
KC
Nakamura
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Matthijs C
0000-0002-1162-1481
MC
Dorst
Yerkes National Primate Research Center, Department of Neurology, Emory University, Atlanta, United States.|Udall Center of Excellence for Parkinson's Disease Research, Emory University, Atlanta, United States.
Yoland
Y
Smith
Medical Research Council Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Oxford, United Kingdom.
Peter J
0000-0001-7141-7071
PJ
Magill
Medical Research Council Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Oxford, United Kingdom.
Andrew
0000-0002-1594-3349
A
Sharott
D000818:Animals; D001369:Axons / Q000502:physiology; D001479:Basal Ganglia / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism; D003342:Corpus Striatum / Q000166:cytology / Q000502:physiology*; D005260:Female; D007395:Interneurons / Q000166:cytology / Q000502:physiology*; D008253:Macaca mulatta; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D017072:Neostriatum / Q000378:metabolism*; D009434:Neural Pathways / Q000166:cytology / Q000502:physiology; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D010320:Parvalbumins / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D064046:Secretagogins / Q000378:metabolism*
D002135:Calcium-Binding Proteins; D010320:Parvalbumins; D064046:Secretagogins
interneuron; mouse; neuroscience; parvalbumin; rat; rhesus macaque; secretagogin; striatum
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