A new α-pyrone from the mangrove endophytic fungus Phomopsis sp. HNY29-2B.
A new α-pyrone derivative, phomopyrone A (1), together with two known compounds (2-3), was isolated from the culture of the mangrove endophytic fungus Phomopsis sp. HNY29-2B. Their structures were determined by detailed analysis of spectroscopic data. The configuration of 1 was further confirmed by X-ray diffraction. All isolated compounds were evaluated for antibacterial and antioxidative activities. Compound 2 exhibited antibacterial activities with minimal inhibition concentration (MIC) values of 25 and 50 μM against Bacillus subtilis and Pseudomonas aeruginosa, and compound 3 showed activities against Staphylococcus aureus and B. subtilis with MIC values of 25 and 50 μM, respectively.
a School of Chemistry and Chemical Engineering , Sun Yat-Sen University , Guangzhou , China.
Runlin
R
Cai
a School of Chemistry and Chemical Engineering , Sun Yat-Sen University , Guangzhou , China.
Senhua
S
Chen
a School of Chemistry and Chemical Engineering , Sun Yat-Sen University , Guangzhou , China.
Zhaoming
Z
Liu
a School of Chemistry and Chemical Engineering , Sun Yat-Sen University , Guangzhou , China.
Chunbing
C
Tan
a School of Chemistry and Chemical Engineering , Sun Yat-Sen University , Guangzhou , China.
Xishan
X
Huang
a School of Chemistry and Chemical Engineering , Sun Yat-Sen University , Guangzhou , China.|b South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center , Guangzhou , China.
Zhigang
Z
She
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification; D000975:Antioxidants / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D001713:Biphenyl Compounds; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D010851:Picrates; D011753:Pyrones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D043982:Rhizophoraceae / Q000382:microbiology*; D021241:Spectrometry, Mass, Electrospray Ionization; D014961:X-Ray Diffraction
D000900:Anti-Bacterial Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D010851:Picrates; D011753:Pyrones; C000617912:phomopyrone A; C004931:1,1-diphenyl-2-picrylhydrazyl
Phomopsis sp; antibacterial activity; endophytic fungus; α-pyrone