Folliculotropic Mycosis Fungoides: Clinical and Histologic Features in Five Patients.
BACKGROUND
Alopecia can be a manifestation of mycosis fungoides (MF); however, the prevalence is unknown.


OBJECTIVE
We sought to describe the clinicopathologic presentation of alopecia in patients with diagnosis of MF.


METHODS
A retrospective analysis of patients with biopsy-proven MF, who were evaluated at our cancer center from 2002 to 2012, was performed to identify patients with alopecia.


RESULTS
Five patients with alopecia were identified from reviewing of 157 patients with MF. The male:female ratio was 3:2, and the mean age of patients was 42.8 years. Two of these patients showed patchy hair loss on scalp which was clinically identical to alopecia areata. In remaining three patients, hair loss was seen in areas of MF lesions, and epidermal changes consisted of patch- and plaque-type lesions of MF, tumors, and follicular lesions (follicular MF) were also present. In two of these patients, lymphadenopathy without any visceral involvement was detected.


CONCLUSIONS
Alopecia was observed in 5 (3.18%) patients with MF, which makes it a rare finding, which included alopecia areata-like patchy loss in 2 and alopecia within MF lesions in 3.
Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Amir Hooshang
AH
Ehsani
Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Arghavan
A
Azizpour
Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Pedram
P
Noormohammadpoor
Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Hasan
H
Seirafi
Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Farshad
F
Farnaghi
Department of Dermatopatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Kambiz
K
Kamyab-Hesari
Department of Emergency Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mehdi
M
Sharifi
Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Maryam
M
Nasimi
Alopecia; folliculotropic mycosis fungoides; mycosis fungoides
Arch Dermatol. 2002 Feb;138(2):191-8
11843638
J Cutan Pathol. 1997 Mar;24(3):164-8
9085152
Am J Surg Pathol. 2007 Sep;31(9):1430-8
17721200
J Invest Dermatol. 1996 Sep;107(3):373-6
8751973
Blood. 2005 May 15;105(10):3768-85
15692063
Acta Derm Venereol. 2013 May;93(3):325-9
23053197
J Am Acad Dermatol. 2010 Mar;62(3):418-26
20079954
J Eur Acad Dermatol Venereol. 2015 May;29(5):964-72
25406034
J Am Acad Dermatol. 2011 Jan;64(1):53-63
21036417
J Invest Dermatol. 1994 Dec;103(6):758-63
7798612
Arch Dermatol. 2010 Jun;146(6):607-13
20566923
Am J Dermatopathol. 1981 Summer;3(2):207-14
6973937
J Am Acad Dermatol. 2014 Nov;71(5):926-34
25044343
Arch Dermatol. 2008 Jun;144(6):738-46
18559762
J Cutan Pathol. 2015 Jan;42(1):22-31
25376535