Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes.
In recent years, rapid discoveries have been made relating to Ca2+handling at specific organelles that have important implications for whole-cell Ca2+homeostasis. In particular, the structures of the endoplasmic reticulum (ER) Ca2+channels revealed by electron cryomicroscopy (cryo-EM), continuous updates on the structure, regulation, and role of the mitochondrial calcium uniporter (MCU) complex, and the analysis of lysosomal Ca2+signaling are milestones on the route towards a deeper comprehension of the complexity of global Ca2+signaling. In this review we summarize recent discoveries on the regulation of interorganellar Ca2+homeostasis and its role in pathophysiology.
Department of Biomedical Sciences, University of Padua, 35131 Padua, Italy. Electronic address: anna.raffaello@unipd.it.
Anna
A
Raffaello
Department of Biomedical Sciences, University of Padua, 35131 Padua, Italy. Electronic address: cristina.mammucari@unipd.it.
Cristina
C
Mammucari
Department of Biomedical Sciences, University of Padua, 35131 Padua, Italy.
Gaia
G
Gherardi
Department of Biomedical Sciences, University of Padua, 35131 Padua, Italy; Neuroscience Institute, National Research Council, 35131 Padua, Italy. Electronic address: rosario.rizzuto@unipd.it.
Rosario
R
Rizzuto
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000235:genetics / Q000378:metabolism; D020013:Calcium Signaling / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D008247:Lysosomes / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism / Q000648:ultrastructure; D054792:Muscle, Striated / Q000378:metabolism / Q000648:ultrastructure; D000071740:ORAI1 Protein / Q000235:genetics / Q000378:metabolism; D019837:Ryanodine Receptor Calcium Release Channel / Q000235:genetics / Q000378:metabolism; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases / Q000235:genetics / Q000378:metabolism; D000071737:Stromal Interaction Molecule 1 / Q000235:genetics / Q000378:metabolism; D010738:Type C Phospholipases / Q000235:genetics / Q000378:metabolism
D015220:Calcium Channels; D000071740:ORAI1 Protein; D019837:Ryanodine Receptor Calcium Release Channel; D000071737:Stromal Interaction Molecule 1; C034703:mitochondrial calcium uniporter; D010738:Type C Phospholipases; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; D002118:Calcium
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