Referential communication abilities in children with 22q11.2 deletion syndrome.
This study describes the performance on a perspective- and role-taking task in 27 children, ages 6-13 years, with 22q11.2 deletion syndrome (22q11.2DS). A cross-cultural design comparing Dutch- and English-speaking children with 22q11.2DS explored the possibility of cultural differences.



Chronologically age-matched and younger typically developing (TD) children matched for receptive vocabulary served as control groups to identify challenges in referential communication.



The utterances of children with 22q11.2DS were characterised as short and simple in lexical and grammatical terms. However, from a language use perspective, their utterances were verbose, ambiguous and irrelevant given the pictured scenes. They tended to elaborate on visual details and conveyed off-topic, extraneous information when participating in a barrier-game procedure. Both types of aberrant utterances forced a listener to consistently infer the intended message. Moreover, children with 22q11.2DS demonstrated difficulty selecting correct speech acts in accordance with contextual cues during a role-taking task.



Both English- and Dutch-speaking children with 22q11.2DS showed impoverished information transfer and an increased number of elaborations, suggesting a cross-cultural syndrome-specific feature.
a Department of Neurosciences, Research Group Experimental Oto-Rhino-Laryngology (ExpORL) , KU Leuven - University of Leuven , Leuven , Belgium.
Ellen
E
Van Den Heuvel
b Department of Communicative Sciences and Disorders , New York University , New York , NY , USA.
Christina
C
ReuterskiöLd
c Center for Childhood Communication , The Children's Hospital of Philadelphia , Philadelphia , PA , USA.
Cynthia
C
Solot
a Department of Neurosciences, Research Group Experimental Oto-Rhino-Laryngology (ExpORL) , KU Leuven - University of Leuven , Leuven , Belgium.
Eric
E
Manders
d Department of Human Genetics , KU Leuven - University of Leuven , Leuven , Belgium.|e Center for Human Genetics , University Hospital Leuven , Leuven , Belgium , and.
Ann
A
Swillen
a Department of Neurosciences, Research Group Experimental Oto-Rhino-Laryngology (ExpORL) , KU Leuven - University of Leuven , Leuven , Belgium.|f Department of Oto-Rhino-Laryngology, Head & Neck Surgery, MUCLA , University Hospital Leuven , Leuven , Belgium.
Inge
I
Zink
D058165:22q11 Deletion Syndrome / Q000150:complications*; D000293:Adolescent; D002648:Child; D003147:Communication Disorders / Q000209:etiology*; D005260:Female; D006801:Humans; D007802:Language; D008297:Male
22q11.2 deletion syndrome; Referential communication; cross-cultural