Phage display as a promising approach for vaccine development.
Bacteriophages are specific antagonists to bacterial hosts. These viral entities have attracted growing interest as optimal vaccine delivery vehicles. Phages are well-matched for vaccine design due to being highly stable under harsh environmental conditions, simple and inexpensive large scale production, and potent adjuvant capacities. Phage vaccines have efficient immunostimulatory effects and present a high safety profile because these viruses have made a constant relationship with the mammalian body during a long-standing evolutionary period. The birth of phage display technology has been a turning point in the development of phage-based vaccines. Phage display vaccines are made by expressing multiple copies of an antigen on the surface of immunogenic phage particles, thereby eliciting a powerful and effective immune response. Also, the ability to produce combinatorial peptide libraries with a highly diverse pool of randomized ligands has transformed phage display into a straightforward, versatile and high throughput screening methodology for the identification of potential vaccine candidates against different diseases in particular microbial infections. These libraries can be conveniently screened through an affinity selection-based strategy called biopanning against a wide variety of targets for the selection of mimotopes with high antigenicity and immunogenicity. Also, they can be panned against the antiserum of convalescent individuals to recognize novel peptidomimetics of pathogen-related epitopes. Phage display has represented enormous promise for finding new strategies of vaccine discovery and production and current breakthroughs promise a brilliant future for the development of different phage-based vaccine platforms.
Immunology Research Center, Tabriz University of Medical sciences, Tabriz, Iran.|Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.|Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Leili
L
Aghebati-Maleki
Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Babak
B
Bakhshinejad
Immunology Research Center, Tabriz University of Medical sciences, Tabriz, Iran.|Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Behzad
B
Baradaran
Immunology Research Center, Tabriz University of Medical sciences, Tabriz, Iran.
Morteza
M
Motallebnezhad
Immunology Research Center, Tabriz University of Medical sciences, Tabriz, Iran.
Ali
A
Aghebati-Maleki
Immunology Research Center, Tabriz University of Medical sciences, Tabriz, Iran.
Hamid
H
Nickho
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. yousefime@tbzmed.ac.ir.|Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. yousefime@tbzmed.ac.ir.
Mehdi
M
Yousefi
Immunology Research Center, Tabriz University of Medical sciences, Tabriz, Iran. jmajidiz@yahoo.com.|Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. jmajidiz@yahoo.com.
Jafar
J
Majidi
Bacteriophage; Biopanning; Mimotope; Peptide library; Phage display; Vaccine development
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