Sarcomatoid Adrenal Carcinoma: Case Report with Contribution to Pathogenesis.
A tumor in the adrenal region with two metastases in the liver was classified as poorly differentiated sarcoma on the base of extensive immunostainings (expression of vimentin, desmin, myogenin, and CD31, no expression of inhibin, melan A). Four years later in a second examination with molecular methods for a study of adrenal sarcomas, this diagnosis must be revised due to the lack of MDM-2 gene amplification and FKHR translocation which exclude sarcoma. Further immunostainings of many other parts of the tumor showed in one area more mature tumor tissue expressing synaptophysin, SF-1, and melan A. From these findings we classified an adrenal cortical cancer with predominant dedifferentiation into a sarcomatoid adrenal carcinoma. The properties of this very rare cancer type are presented and discussed.
Institute of Pathology and Neuropathology of the University of Hamburg, Martinistraße 52, 20246, Hamburg, UKE, Germany. w.saeger@uke.de.
Wolfgang
W
Saeger
Institute of Pathology, Hospital Deggendorf, 94469, Deggendorf, Germany.
Werner
W
Mohren
Clinic for Surgery, Hospital Deggendorf, 94469, Deggendorf, Germany.
Matthias
M
Behrend
Institute of Pathology of the University of Hamburg, 20246, Hamburg, UKE, Germany.
Peter
P
Iglauer
Institute of Pathology of the University of Hamburg, 20246, Hamburg, UKE, Germany.
Waldemar
W
Wilczak
D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis / Q000473:pathology*; D018268:Adrenocortical Carcinoma / Q000175:diagnosis / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis*; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D008875:Middle Aged; D012509:Sarcoma / Q000175:diagnosis / Q000473:pathology
D014408:Biomarkers, Tumor
Adrenal carcinoma; Immunostaining; Molecular pathology; Sarcoma; Sarcomatoid carcinoma
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