Association between serum vitamin D levels and gastric cancer: A retrospective chart analysis.
OBJECTIVE
To determine whether there is an increased risk of gastric adenocarcinoma associated with vitamin D deficiency (VDd).


METHODS
A retrospective case control study was performed of all patients diagnosed with gastric adenocarcinoma between 2005 and 2015. After we excluded the patients without a documented vitamin D level, 49 patients were included in our study.


RESULTS
The average age of patients with gastric adenocarcinoma and documented vitamin D level was 64 years old (95%CI: 27-86) and average vitamin D level was 20.8 mg/dL (95%CI: 4-44). Compared to a matched control group, the prevalence of VDd/insufficiency in patients with gastric adenocarcinoma was significantly higher than normal vitamin D levels (83.7% vs 16.3%). Forty-one patients (83.7%) with adenocarcinoma showed VDd/insufficiency compared to 18 (37%) patients with normal vitamin D level without gastric cancer (OR: 8.8, 95%CI: 5-22, P value < 0.0001). The average age of males with gastric adenocarcinoma diagnosis was 60 years old vs 68 years old for females (P = 0.01). Stage II gastric adenocarcinoma was the most prevalent in our study (37%).


CONCLUSIONS
We reported a positive relationship between VDd and gastric adenocarcinoma, that is to say, patients with decreased VDd levels have an increased propensity for gastric adenocarcinoma.
Neil Vyas, Hassan Alkhawam, Carmine Catalano, Robert Sogomonian, Department of Internal Medicine, Elmhurst Hospital Center, Elmhurst, NY 11373, United States.
Neil
N
Vyas
Neil Vyas, Hassan Alkhawam, Carmine Catalano, Robert Sogomonian, Department of Internal Medicine, Elmhurst Hospital Center, Elmhurst, NY 11373, United States.
Rafael Ching
RC
Companioni
Neil Vyas, Hassan Alkhawam, Carmine Catalano, Robert Sogomonian, Department of Internal Medicine, Elmhurst Hospital Center, Elmhurst, NY 11373, United States.
Melik
M
Tiba
Neil Vyas, Hassan Alkhawam, Carmine Catalano, Robert Sogomonian, Department of Internal Medicine, Elmhurst Hospital Center, Elmhurst, NY 11373, United States.
Hassan
H
Alkhawam
Neil Vyas, Hassan Alkhawam, Carmine Catalano, Robert Sogomonian, Department of Internal Medicine, Elmhurst Hospital Center, Elmhurst, NY 11373, United States.
Carmine
C
Catalano
Neil Vyas, Hassan Alkhawam, Carmine Catalano, Robert Sogomonian, Department of Internal Medicine, Elmhurst Hospital Center, Elmhurst, NY 11373, United States.
Robert
R
Sogomonian
Neil Vyas, Hassan Alkhawam, Carmine Catalano, Robert Sogomonian, Department of Internal Medicine, Elmhurst Hospital Center, Elmhurst, NY 11373, United States.
Joel
J
Baum
Neil Vyas, Hassan Alkhawam, Carmine Catalano, Robert Sogomonian, Department of Internal Medicine, Elmhurst Hospital Center, Elmhurst, NY 11373, United States.
Aaron
A
Walfish
Adenocarcinoma; Gastric cancer; Vitamin D
Int J Clin Exp Pathol. 2015 Oct 01;8(10 ):13176-84
26722516
J Transl Med. 2012 Jan 27;10:16
22284859
Calcif Tissue Int. 2013 Feb;92(2):77-98
22782502
Eur J Oncol Nurs. 2005;9 Suppl 2:S51-63
16437758
Am J Clin Nutr. 2007 Jun;85(6):1586-91
17556697
Differentiation. 2007 Mar;75(3):193-207
17288543
Endocr Relat Cancer. 2013 Mar 22;20(2):R31-47
23319494
World J Gastroenterol. 2006 Jul 21;12(27):4296-303
16865769
Hepatogastroenterology. 2013 Jun;60(124):943-8
23298900
J Korean Med Sci. 2012 Sep;27(9):1037-43
22969249
J Steroid Biochem Mol Biol. 2014 Oct;144 Pt A:5-11
24239506
Prog Biophys Mol Biol. 2006 Sep;92(1):4-8
16563471
Best Pract Res Clin Endocrinol Metab. 2011 Aug;25(4):543-59
21872797
Int J Radiat Oncol Biol Phys. 1995 May 15;32(2):341-7
7751175
Nat Rev Cancer. 2007 Sep;7(9):684-700
17721433
Nat Rev Cancer. 2014 May;14 (5):342-57
24705652
Int J Mol Med. 2014 May;33(5):1177-84
24573222
FEBS J. 2010 Feb;277(4):989-99
20089040
Br J Nutr. 2003 May;89(5):552-72
12720576
Nutr Cancer. 2013;65(7):1067-75
24099173
Helicobacter. 2013 Sep;18 Suppl 1:34-8
24011243
J Steroid Biochem Mol Biol. 2005 Oct;97(1-2):13-9
16026981
Ann Transl Med. 2014 Jan;2(1):9
25332985
Cancer Invest. 2012 Oct;30(8):604-14
22963190
Br J Cancer. 2007 Jul 2;97(1):123-8
17551495
Biochem J. 2012 Jan 1;441(1):61-76
22168439