The effect of the severity of obstructive sleep apnea syndrome on telomere length.
Aging is associated with an increase in the prevalence of obstructive sleep apnea syndrome (OSAS) as well as the shortening of telomeres. It is known that OSAS-related factors are stimuli that can contribute to the acceleration of cellular senescence. Thus, the present study aimed to compare the leukocyte telomere length (LTL) between OSAS patients and controls, as well as to verify the correlation between LTL and sleep parameters. We used DNA extracted of 928 individuals from EPISONO to measure the LTL by the quantitative real-time polymerase chain reaction. All individuals were subjected to one full-night polysomnography. LTL was significantly shorter in OSAS patients compared to controls. The results showed negative correlations between LTL and the following variables: apnea-hypopnea index, respiratory disturbance index, desaturation index and wake after sleep onset. LTL was positively correlated with sleep efficiency, total sleep time, basal, minimum and maximum oxygen saturation. Lastly, it was observed that OSAS severity was associated with shorter LTL even after adjusting for sex, age, years of schooling, body mass index, diabetes, stroke and heart attack. In conclusion, our study indicates the presence of an association between LTL and OSAS and a significant impact of severity of OSAS in telomeres shortening.
Departamento de Psicobiologia, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brasil.
Priscila Farias
PF
Tempaku
Departamento de Psicobiologia, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brasil.
Diego Robles
DR
Mazzotti
Departamento de Psicobiologia, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brasil.
Camila
C
Hirotsu
Departamento de Psicobiologia, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brasil.
Monica Levy
ML
Andersen
Laboratório Interdisciplinar de Neurociências Clínicas (LINC), Universidade Federal de São Paulo (UNIFESP), São Paulo, Brasil.|Departamento de Morfologia e Genética, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brasil.
Gabriela
G
Xavier
Laboratório Interdisciplinar de Neurociências Clínicas (LINC), Universidade Federal de São Paulo (UNIFESP), São Paulo, Brasil.|Amity Institute of Biotechnology, Amity University Uttar Pradesh, Noida, India.
Pawan Kumar
PK
Maurya
Laboratório Interdisciplinar de Neurociências Clínicas (LINC), Universidade Federal de São Paulo (UNIFESP), São Paulo, Brasil.|Department of Psychiatry, University of Tuebingen, Tuebingen, Germany.|Grupo de Pesquisa em Neurociência Comportamental e Molecular do Transtorno Bipolar, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brasil.
Lucas Bortolotto
LB
Rizzo
Laboratório Interdisciplinar de Neurociências Clínicas (LINC), Universidade Federal de São Paulo (UNIFESP), São Paulo, Brasil.|Grupo de Pesquisa em Neurociência Comportamental e Molecular do Transtorno Bipolar, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brasil.
Elisa
E
Brietzke
Laboratório Interdisciplinar de Neurociências Clínicas (LINC), Universidade Federal de São Paulo (UNIFESP), São Paulo, Brasil.|Departamento de Morfologia e Genética, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brasil.
Sintia Iole
SI
Belangero
Departamento de Psicobiologia, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brasil.
Lia
L
Bittencourt
Departamento de Psicobiologia, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brasil.
Sergio
S
Tufik
D000328:Adult; D003430:Cross-Sectional Studies; D004247:DNA / Q000032:analysis / Q000235:genetics; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D060888:Real-Time Polymerase Chain Reaction; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000097:blood / Q000473:pathology / Q000503:physiopathology*; D016615:Telomere / Q000235:genetics*; D059506:Telomere Shortening / Q000235:genetics*
D004247:DNA
Gerotarget; aging; obstructive sleep apnea syndrome; sleep; telomeres
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