Anxiolytic-like effect of a novel peptide isolated from the venom of the social wasp Synoeca surinama.
Pathological anxiety is among the most common psychiatric illnesses, but current treatment is highly limited. In this study, we investigated the potential anxiolytic-like effects of a peptide isolated from Synoeca surinama venom. Rats treated with this peptide spent more time exploring the open arms of elevated plus maze, which indicates an anxiolytic-like profile for this peptide. This study is the first to show the pharmacological use of S. surinama venom in the treatment of anxiety.
Neuropharmacology Laboratory, Department of Physiological Sciences, Institute of Biological Sciences, University of Brasília, Brasília, Brazil. Electronic address: flaviia.medeiros@hotmail.com.
Flávia M M
FM
Gomes
Neuropharmacology Laboratory, Department of Physiological Sciences, Institute of Biological Sciences, University of Brasília, Brasília, Brazil. Electronic address: paniago.bio@gmail.com.
Cássia K
CK
Paniago
Neuropharmacology Laboratory, Department of Physiological Sciences, Institute of Biological Sciences, University of Brasília, Brasília, Brazil. Electronic address: daniel.microbiologia@gmail.com.
Daniel O
DO
Freire
Neuropharmacology Laboratory, Department of Physiological Sciences, Institute of Biological Sciences, University of Brasília, Brasília, Brazil. Electronic address: adolfo_quimica@hotmail.com.
Adolfo C B
AC
Souza
Neuropharmacology Laboratory, Department of Physiological Sciences, Institute of Biological Sciences, University of Brasília, Brasília, Brazil; Evolutionary Ecology Laboratory, Department of Animal and Plant Biology, Biological Sciences Center, State University of Londrina, Londrina, Brazil. Electronic address: robalinho.lima@gmail.com.
Marcos R
MR
Lima
S-Inova Biotech, Post-Graduation on Biotechnology, Dom Bosco Catholic University, Campo Grande, Brazil; Center for Biochemical and Proteomics Analyses, Catholic University of Brasília, Brasília, Brazil. Electronic address: juroyal@gmail.com.
Nelson G
NG
Oliveira-Júnior
S-Inova Biotech, Post-Graduation on Biotechnology, Dom Bosco Catholic University, Campo Grande, Brazil; Center for Biochemical and Proteomics Analyses, Catholic University of Brasília, Brasília, Brazil. Electronic address: ocfranco@gmail.com.
Octavio L
OL
Franco
Neuropharmacology Laboratory, Department of Physiological Sciences, Institute of Biological Sciences, University of Brasília, Brasília, Brazil. Electronic address: mmortari@unb.br.
Márcia R
MR
Mortari
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D010455:Peptides / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014862:Wasp Venoms / Q000737:chemistry*
D014151:Anti-Anxiety Agents; D010455:Peptides; D014862:Wasp Venoms
Anxiolytic activity; Elevated plus maze; Pathological anxiety; Peptides; Wasp venom