Potential blood clotting factors and anticoagulants.
Hemostasis initiates a wound healing process and stops bleeding of blood within a damaged tissue, an important process in human and animal systems. However, this process needs to revert temporarily during surgery and analyze the clotting mechanism. In the past decade, heparin has been used widely as an anticoagulant in surgery to prevent unwanted blood clotting as it is not expensive, not difficult to control, lack of suitable replacement as well as less harmful to the human. However, heparin has several disadvantages, which include thrombocytopenia and non-specific plasma binding. Moreover, using heparin it may lead dysfunction and platelet aggregation. In this overview, potential clotting factors and anticoagulants are reviewed and special focus was given to get more insights.
School of Bioprocess Engineering, Universiti Malaysia Perlis, 02600 Arau, Perlis, Malaysia.
Ng Zhang
NZ
Jin
School of Bioprocess Engineering, Universiti Malaysia Perlis, 02600 Arau, Perlis, Malaysia; Institute of Nano Electronic Engineering, Universiti Malaysia Perlis, 01000 Kangar, Perlis, Malaysia. Electronic address: subash@unimap.edu.my.
Subash C B
SCB
Gopinath
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D001777:Blood Coagulation; D001779:Blood Coagulation Factors / Q000378:metabolism*; D005164:Factor IX / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D013917:Thrombin / Q000378:metabolism
D000925:Anticoagulants; D001779:Blood Coagulation Factors; D005164:Factor IX; D013917:Thrombin
Anticoagulant; Aptamer; Factor IX; Factor IX-binding protein; Hemostasis; Heparin; Thrombin