Understanding osteomyelitis and its treatment through local drug delivery system.
Chronic osteomyelitis is a major challenge in bone surgery. Conventional use of antibiotics is not an effective way to control the malaise due to so many reasons. Determination of optimal treatment strategy becomes difficult for the orthopaedic surgeons and as a consequence, the patients suffer not only from therapeutic failure but also due to adverse side effects of antibiotics and financial loss due to additional stay at hospitals. A wide application of carrier systems, as a medium for local delivery of antibiotics, is being used experimentally and clinically for the treatment of osteomyelitis. This kind of delivery system provides sustained higher concentration of antibiotics at the infection site with reduced possibility of toxicity. This review highlight etiology and pathophysiology of osteomyelitis, current therapeutic options with their limitations, and potentiality of biomaterial based carrier materials impregnated with antibiotics as local delivery approach.
Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, Kolkata, India. Electronic address: samitnandi1967@gmail.com.
Samit Kumar
SK
Nandi
Eastern Regional Station, Indian Veterinary Research Institute, Kolkata, India.
Samiran
S
Bandyopadhyay
Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, Kolkata, India.
Piyali
P
Das
Department of Veterinary Microbiology, West Bengal University of Animal and Fishery Sciences, Kolkata, India.
Indranil
I
Samanta
Department of Teaching Veterinary Clinical Complex, West Bengal University of Animal and Fishery Sciences, Mohanpur, India.
Prasenjit
P
Mukherjee
Subject Matter Specialist, Krishi Vigyan Kendra, Nimpith, India.
Subhasis
S
Roy
Bioceramics and Coating Division, CSIR-Central Glass and Ceramic Research Institute, Kolkata, India. Electronic address: biswa_kundu@rediffmail.com.
Biswanath
B
Kundu
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001672:Biocompatible Materials; D016503:Drug Delivery Systems; D006801:Humans; D010019:Osteomyelitis / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D012307:Risk Factors
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials
Biodegradable carriers; Drug release; Local antibiotic delivery system; Non-biodegradable carriers; Osteomyelitis; Pathophysiology