Noninvasive detection of microaneurysms in diabetic retinopathy by swept-source optical coherence tomography.
OBJECTIVE
A method of identifying retinal vascular microaneurysms (MAs) in nonproliferative diabetic retinopathy (NPDR) using swept-source optical coherence tomography (SS-OCT).


METHODS
SS-OCT images were acquired in 17 eyes with NPDR using prototype SS-OCT device and fluorescein angiography (FA) images were obtained simultaneously. MAs identified on SS-OCT slabs were correlated to MAs identified on FA.


RESULTS
MAs were identified in SS-OCT slabs in 15/17 eyes, resulting in NPDR diagnosis rate of 88%. Mean number of MAs identified on FA was 11.7±11.9 (total 199) and was 8.1±9.3 (total 137) on SS-OCT. Wilcoxon rank sum test showed no significant difference in MAs detected on SS-OCT and FA (P=0.2995) across eyes. Wilcoxon rank sum test showed SS-OCT detected slightly fewer MAs than FA per eye (3.65 less,P=0.0009).


CONCLUSIONS
SS-OCT visualization of MAs could serve as a tool for diagnosing NPDR, and possibly applied as an imaging biomarker for population-based diabetic retinopathy screening.
Department of Ophthalmology, Byers Eye Institute at Stanford, Stanford University School of Medicine, Palo Alto, CA, USA.
Sarah
S
Cheng
Department of Ophthalmology, Byers Eye Institute at Stanford, Stanford University School of Medicine, Palo Alto, CA, USA.
Theodore
T
Leng
diabetic retinopathy; optical coherence tomography; swept-source optical coherence tomography
Am J Ophthalmol. 2012 May;153(5):861-867.e1
22300473
Ophthalmology. 1986 May;93(5):586-9
3725317
Ophthalmology. 2006 Jan;113(1):48-57
16343625
Ophthalmologica. 2009;223(5):284-91
19372722
Ophthalmology. 2011 Feb;118(2):359-67
20656355
Invest Ophthalmol Vis Sci. 2005 Jan;46(1):310-6
15623790
Invest Ophthalmol Vis Sci. 2003 Dec;44(12):5335-41
14638735
Int Ophthalmol Clin. 1989 Fall;29(3):200-5
2526795
J Biomed Opt. 2004 Jan-Feb;9(1):47-74
14715057
Diabetologia. 1999 Sep;42(9):1107-12
10447523
Ophthalmology. 2004 Nov;111(11):2033-43
15522369
Ophthalmic Surg Lasers Imaging Retina. 2015 Sep;46(8):796-805
26431294
Am J Ophthalmol. 2010 Dec;150(6):840-8
20855054
Ophthalmologica. 2009;223(5):292-7
19372723
Arch Ophthalmol. 1995 Nov;113(11):1386-91
7487599
Ophthalmology. 2009 Jun;116(6):1158-67
19395034
Diabet Med. 2000 Jul;17(7):495-506
10972578