Similarities and differences in coatings for magnesium-based stents and orthopaedic implants.
Magnesium (Mg)-based biodegradable materials are promising candidates for the new generation of implantable medical devices, particularly cardiovascular stents and orthopaedic implants. Mg-based cardiovascular stents represent the most innovative stent technology to date. However, these products still do not fully meet clinical requirements with regards to fast degradation rates, late restenosis, and thrombosis. Thus various surface coatings have been introduced to protect Mg-based stents from rapid corrosion and to improve biocompatibility. Similarly, different coatings have been used for orthopaedic implants, e.g., plates and pins for bone fracture fixation or as an interference screw for tendon-bone or ligament-bone insertion, to improve biocompatibility and corrosion resistance. Metal coatings, nanoporous inorganic coatings and permanent polymers have been proved to enhance corrosion resistance; however, inflammation and foreign body reactions have also been reported. By contrast, biodegradable polymers are more biocompatible in general and are favoured over permanent materials. Drugs are also loaded with biodegradable polymers to improve their performance. The key similarities and differences in coatings for Mg-based stents and orthopaedic implants are summarized.
Department of Chemical, Biological and Bio-Engineering, North Carolina Agricultural and Technical State University, Greensboro, NC, USA; National Science Foundation (NSF) Engineering Research Center-Revolutionizing Metallic Biomaterials, North Carolina Agricultural and Technical State University, Greensboro, NC, USA.
Jun
J
Ma
Department of Chemical, Biological and Bio-Engineering, North Carolina Agricultural and Technical State University, Greensboro, NC, USA; National Science Foundation (NSF) Engineering Research Center-Revolutionizing Metallic Biomaterials, North Carolina Agricultural and Technical State University, Greensboro, NC, USA.
Marc
M
Thompson
Department of Chemical, Biological and Bio-Engineering, North Carolina Agricultural and Technical State University, Greensboro, NC, USA; National Science Foundation (NSF) Engineering Research Center-Revolutionizing Metallic Biomaterials, North Carolina Agricultural and Technical State University, Greensboro, NC, USA.
Nan
N
Zhao
Department of Chemical, Biological and Bio-Engineering, North Carolina Agricultural and Technical State University, Greensboro, NC, USA; National Science Foundation (NSF) Engineering Research Center-Revolutionizing Metallic Biomaterials, North Carolina Agricultural and Technical State University, Greensboro, NC, USA.
Donghui
D
Zhu
Biocompatibility; Biodegradable materials; Coatings; Drug elution; Magnesium alloys
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