The Application of Frailty to the Modern Cardiac Risk Assessment: a Case-Based Review.
Cardiac risk assessment in aging patients poses a significant challenge to the practicing clinician, particularly when evaluating the use of invasive procedures. Frailty is a valuable risk marker that has been associated with worse outcomes in patients with coronary artery disease, heart failure, and aortic stenosis. Integrating the available frailty studies into cardiac risk assessments can help improve shared decision-making between physicians and their patients. In this review, we provide an up-to-date, case-based appraisal of the available clinical trial data focusing on the impact of frailty in patients with cardiovascular disease.
Department of Cardiology, Columbia University Medical Center, New York, NY, USA ; Division of Cardiology, 622 West 168th Street, PH 3-347, New York, NY 10032, USA.
Matthew
M
Finn
Department of Cardiology, Columbia University Medical Center, New York, NY, USA.
Philip
P
Green
Aging; Aortic stenosis; Cardiac risk assessment; Coronary artery disease; Elderly; Frailty; Geriatric; Heart failure; Transcatheter aortic valve replacement
J Card Fail. 2010 May;16(5):390-5
20447574
J Thorac Cardiovasc Surg. 2014 Dec;148(6):3110-7
25199821
J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M146-56
11253156
Am Heart J. 2013 Nov;166(5):887-94
24176445
Prog Cardiovasc Dis. 2014 Sep-Oct;57(2):215-25
25216621
Lancet. 2015 Feb 14;385(9968):e7-9
25468154
Circulation. 2011 Nov 29;124(22):2397-404
22064593
Am J Cardiol. 2012 Jun 1;109 (11):1569-75
22440119
Prog Cardiovasc Dis. 2014 Sep-Oct;57(2):134-43
25216612
J Clin Epidemiol. 1996 May;49(5):519-26
8636725
J Am Coll Cardiol. 2010 Nov 9;56(20):1668-76
21050978
J Am Coll Surg. 2015 May;220(5):904-11.e1
25907870
J Am Coll Cardiol. 2010 Mar 16;55(11):1080-90
20096533
J Gerontol A Biol Sci Med Sci. 2004 Mar;59(3):255-63
15031310
JACC Cardiovasc Interv. 2015 Feb;8(2):315-23
25700755
Am J Cardiol. 2015 Jul 15;116(2):264-9
25963221
Am J Cardiol. 2013 Sep 1;112(5):700-6
23725996
J Am Coll Cardiol. 2015 Mar 17;65(10):976-83
25766943
J Am Geriatr Soc. 2012 Nov;60(11):2110-5
23043490
Expert Rev Cardiovasc Ther. 2013 Jun;11(6):761-72
23750685
J Am Coll Cardiol. 2014 Dec 2;64(21):2235-43
25456759
J Am Coll Cardiol. 2014 Mar 4;63(8):747-62
24291279
J Am Coll Surg. 2010 Jun;210(6):901-8
20510798
Circulation. 2010 Mar 2;121(8):973-8
20159833
Eur J Clin Invest. 2005 Dec;35(12):723-30
16313247
J Am Geriatr Soc. 2012 Aug;60(8):1487-92
22881367
Rev Esp Cardiol (Engl Ed). 2015 Aug;68(8):653-6
26129717