Hemodynamics in Coronary Arterial Tree of Serial Stenoses.
Serial segmental narrowing frequently occurs in humans, which alters coronary hemodynamics and further affects atherosclerotic progression and plaque formation. The objective of this study was to understand the distribution of hemodynamic parameters in the epicardial left main coronary arterial (LMCA) tree with serial stenoses reconstructed from patient computer tomography angiography (CTA) images. A finite volume method was used in conjunction with the inlet pressure wave and outlet flow resistance. The time-averaged wall shear stress (TAWSS) and oscillatory shear index (OSI) were determined from the flow field. A stenosis at a mother vessel mainly deteriorated the hemodynamics near the bifurcation while a stenosis at a daughter vessel affected the remote downstream bifurcation. In comparison with a single stenosis, serial stenoses increased the peak pressure gradient along the main trunk of the epicardial left anterior descending arterial tree by > 50%. An increased distance between serial stenoses further increased the peak pressure gradient. These findings have important implications on the diagnosis and treatment of serial coronary stenoses.
Department of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing, China.|State Key Laboratory for Turbulence and Complex Systems, College of Engineering, Peking University, Beijing, China.|School of Biomedical Engineering, Capital Medical University, Beijing, China.
Xi
X
Chen
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yang
Y
Gao
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Bin
B
Lu
Department of Cardiology, Affiliated hospital of Hebei University, Hebei University, Baoding, China.
Xinwei
X
Jia
National Heart Center Singapore, Singapore, Singapore.|Duke-NUS Graduate Medical School Singapore, Singapore, Singapore.
Liang
L
Zhong
California Medical Innovations Institute, San Diego, California, United States of America.
Ghassan S
GS
Kassab
Department of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing, China.|State Key Laboratory for Turbulence and Complex Systems, College of Engineering, Peking University, Beijing, China.
Wenchang
W
Tan
Department of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing, China.|State Key Laboratory for Turbulence and Complex Systems, College of Engineering, Peking University, Beijing, China.
Yunlong
http://orcid.org/0000-0003-4121-3224
Y
Huo
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