Contemporary molecular tests for prognosis and treatment guidance for castration-resistant prostate cancer.
Currently, clinical factors related to the malignancy and patient-related factors such as performance status and comorbidities are employed to select agents to treat metastatic castration resistant prostate cancer (mCRPC). Areas covered: This paper covers emerging molecular panels that may be used in the clinic as prognostic or predictive biomarkers to treat mCRPC. Expert commentary: The expression of androgen receptor variant (AR-V)-7 in circulating tumor cells appears especially promising to select patients for taxane chemotherapy versus androgen inhibitors, abiraterone and enzalutamide. Additionally, the presence of DNA repair alterations such as BRCA alterations are rapidly emerging as a predictive biomarker to develop precision medicine using PARP inhibitors for these patients.
a University Federico II , Department of Medical Oncology , Naples , Italy.|b Istituto Zooprofilattico Sperimentale del Mezzogiorno , Department of Medical Oncology , Portici , Italy.
Carlo
C
Buonerba
a University Federico II , Department of Medical Oncology , Naples , Italy.
Giuseppe
G
Di Lorenzo
c Comprehensive Cancer Center, University of Alabama at Birmingham (UAB) , Department of Medicine, Section of Hematology-Oncology , Birmingham , AL , USA.
Guru
G
Sonpavde
D014408:Biomarkers, Tumor; D000066491:Clinical Decision-Making; D005784:Gene Amplification; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D025202:Molecular Diagnostic Techniques; D009154:Mutation; D018358:Neuroendocrine Tumors / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D064129:Prostatic Neoplasms, Castration-Resistant / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality* / Q000628:therapy; D011944:Receptors, Androgen / Q000235:genetics / Q000378:metabolism; D016896:Treatment Outcome
C410798:AR protein, human; D014408:Biomarkers, Tumor; D011944:Receptors, Androgen
Prostate cancer; castration-resistant; metastatic; molecular; predictive; prognostic