Traditional herbal remedies and dietary spices from Cameroon as novel sources of larvicides against filariasis mosquitoes?
In Cameroon, many dietary spices are used by traditional healers to cure several diseases such as cancer and microbial infections. Aframomum daniellii, Dichrostachys cinerea and Echinops giganteus are Cameroonian spices widely used as flavourings and as food additives. Moreover, they are traditionally herbal remedies employed to treat several diseases, as well as to control populations of insect pests. In this research, we analysed the chemical composition of A. daniellii, D. cinerea and E. giganteus essential oils and we evaluated their larvicidal potential against larvae of the filariasis and West Nile virus vector Culex quinquefasciatus. The essential oils were obtained from different plant parts by hydrodistillation and their composition was analysed by GC-MS. The three spices exhibited different volatile chemical profiles, being characterized by 1,8-cineole, sabinene and β-pinene (A. daniellii), geraniol and terpinen-4-ol (D. cinerea), and silphiperfol-6-ene and presilphiperfolan-8-ol (E. giganteus). Results showed that the highest larvicidal toxicity on Cx. quinquefasciatus was exerted by D. cinerea essential oil (LC50= 39.1 μL L-1), followed by A. daniellii (pericarp essential oil: LC50= 65.5 μL L-1; leaves: LC50= 65.5μL L-1; seeds: LC50= 106.5μL L-1) and E. giganteus (LC50= 227.4 μL L-1). Overall, the chance to use the D. cinerea essential oil against Cx. quinquefasciatus young instars seems promising, since it is effective at moderate doses and could be an advantageous alternative to build newer mosquito control tools.
Crop Research Institute, Drnovska 507, 161 06, Prague 6, Czech Republic.
Roman
R
Pavela
School of Pharmacy, University of Camerino, Camerino, Italy.
Filippo
F
Maggi
Laboratory of Environmental and Applied Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.|Laboratory of Biochemistry of Medicinal Plants, Food Science and Nutrition, Faculty of Science, University of Dschang, Dschang, Cameroon.
Hélène
H
Mbuntcha
Laboratory of Environmental and Applied Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.|Laboratory of Biochemistry of Medicinal Plants, Food Science and Nutrition, Faculty of Science, University of Dschang, Dschang, Cameroon.
Verlaine
V
Woguem
Laboratory of Environmental and Applied Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.|Laboratory of Biochemistry of Medicinal Plants, Food Science and Nutrition, Faculty of Science, University of Dschang, Dschang, Cameroon.
Hervet Paulin Dongmo
HP
Fogang
Laboratory of Biochemistry of Medicinal Plants, Food Science and Nutrition, Faculty of Science, University of Dschang, Dschang, Cameroon.
Hilaire Macaire
HM
Womeni
Laboratory of Environmental and Applied Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
Léon Azefack
LA
Tapondjou
School of Science and Technology, University of Camerino, Camerino, Italy.
Luciano
L
Barboni
Department of Environmental Biology, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.
Marcello
M
Nicoletti
Department of Agriculture, Food and Environment, University of Pisa, via del Borghetto 80, 56124, Pisa, Italy.
Angelo
A
Canale
Department of Agriculture, Food and Environment, University of Pisa, via del Borghetto 80, 56124, Pisa, Italy. benelli.giovanni@gmail.com.
Giovanni
G
Benelli
D000818:Animals; D000852:Anopheles / Q000187:drug effects* / Q000254:growth & development; D002163:Cameroon; D003465:Culex / Q000187:drug effects* / Q000254:growth & development; D005368:Filariasis / Q000635:transmission; D007303:Insect Vectors / Q000187:drug effects* / Q000254:growth & development; D007306:Insecticides / Q000737:chemistry / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects* / Q000254:growth & development; D009032:Mosquito Control / Q000379:methods; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D017365:Spices / Q000032:analysis*
D007306:Insecticides; D009822:Oils, Volatile; D010936:Plant Extracts
Aframomum daniellii; Culex quinquefasciatus; Dichrostachys cinerea; Echinops giganteus; Essential oil; Rift Valley fever; West Nile virus
Parasitol Res. 2015 Aug;114(8):2801-5
26093499
J Ethnopharmacol. 2007 Mar 1;110(1):99-104
17097842
J Org Chem. 2011 Mar 18;76(6):1874-82
21344897
J Ethnopharmacol. 2012 Jul 13;142(2):374-82
22595661
Phytomedicine. 1999 Oct;6(4):251-6
10589444
J Ethnopharmacol. 2011 Apr 12;134(3):803-12
21291988
Parasite. 2009 Sep;16(3):223-6
19839268
Parasitol Res. 2016 Apr;115(4):1363-73
26758450
Parasite. 2012 Nov;19(4):427-32
22910616
Parasitol Res. 2006 Sep;99(4):478-90
16642384
Parasitol Res. 2015 Oct;114(10):3835-53
26149532
Parasitol Res. 2015 Sep;114(9):3201-12
26239801
Parasitol Res. 2014 Jan;113(1):251-9
24146210
Parasitol Res. 2016 Jul;115(7):2771-8
27026503
Parasitol Res. 2016 Feb;115(2):807-15
26518773
Parasitol Res. 2006 Sep;99(4):473-7
16642385
BMC Complement Altern Med. 2011 Nov 01;11:104
22044718
Parasitol Res. 2016 Jun;115(6):2131-7
27053131
Res Vet Sci. 2016 Feb;104:77-82
26850541
Parasitol Res. 2006 Sep;99(4):466-72
16642386
Food Chem. 2014 Apr 15;149:183-9
24295693
J Ethnobiol Ethnomed. 2014 Feb 12;10:22
24521138
Parasitol Res. 2006 Sep;99(4):491-9
16642383
Exp Parasitol. 2016 Aug;167:103-8
27260568
Parasitol Res. 2012 May;110(5):2013-21
22160253
J Food Prot. 2009 Jul;72(7):1468-71
19681271
J Ethnopharmacol. 2013 Aug 26;149(1):245-53
23827757
BMC Complement Altern Med. 2014 Feb 17;14:58
24533718
Ann Trop Med Parasitol. 2002 Dec;96 Suppl 2:S47-53
12625917
Enzyme Microb Technol. 2016 Dec;95:58-68
27866627
Parasitol Res. 2015 Jan;114(1):227-36
25327954
Phytother Res. 2004 Jun;18(6):435-48
15287066
Phytochemistry. 2004 Jul;65(14):2101-5
15279979
Chem Biodivers. 2014 Jan;11(1):161-9
24443436
Parasitol Res. 2016 May;115(5):1747-54
26932263
Parasitol Res. 2016 Jan;115(1):23-34
26541154