Protective effects of batroxobin on a nigrostriatal pathway injury in mice.
Traumatic brain injury triggers a series of damaged processes, such as neuronal death and apoptosis, inflammation and scar formation, which contribute to evolution of brain injury. The present study investigated the neuroprotective effects of batroxobin, a drug widely used clinically for ischemia, in a nigrostriatal pathway injury model. Mice subjected to the nigrostriatal pathway injury were injected with batroxobin (30 BU/kg) or vehicle immediately after injury. The behavioral studies showed that batroxobin could improve the motor function in injured mice in long term. Batroxobin also reduced neuronal apoptosis and inflammation at the acute stage. Moreover, administration of batroxobin attenuated the scar formation and reduced the lesion size at 4 and 14days after brain injury. These results suggest that batroxobin has beneficial effects on the nigrostriatal pathway injury, indicating a potential clinical application.
Department of Human Anatomy, College of Basic Medical Sciences, China Medical University, Shenyang, China.
Dan
D
Li
Department of Human Anatomy, College of Basic Medical Sciences, China Medical University, Shenyang, China.
Lei
L
Tong
Department of Health and Dietetics, Faculty of Health and Medical Science, Teikyo Heisei University, Tokyo 170-8445, Japan.
Hitoshi
H
Kawano
Department of Human Anatomy, College of Basic Medical Sciences, China Medical University, Shenyang, China.
Nan
N
Liu
Department of Human Anatomy, College of Basic Medical Sciences, China Medical University, Shenyang, China.
Lu
L
Liu
Department of Human Anatomy, College of Basic Medical Sciences, China Medical University, Shenyang, China. Electronic address: 377317599@qq.com.
Hong-Peng
HP
Li
D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D012103:Batroxobin / Q000494:pharmacology*; D002921:Cicatrix / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D003342:Corpus Striatum / Q000187:drug effects* / Q000276:immunology / Q000293:injuries* / Q000473:pathology; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009434:Neural Pathways / Q000187:drug effects / Q000276:immunology / Q000293:injuries / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D011897:Random Allocation; D013378:Substantia Nigra / Q000187:drug effects* / Q000276:immunology / Q000293:injuries* / Q000473:pathology
D018696:Neuroprotective Agents; D012103:Batroxobin
Batroxobin; Inflammatory; Neuronal apoptosis; Nigrostriatal pathway injury; Scar formation