Association of ACYP2 and TSPYL6 Genetic Polymorphisms with Risk of Ischemic Stroke in Han Chinese Population.
The development of ischemic stroke is associated with advanced age. Telomere length, as a marker of biological aging, has been reported to influence the risk of several age-related diseases, including ischemic stroke. Recent studies have identified the genetic variant within ACYP2 and TSPYL6 associated with shorter telomere length. The objective of this study is to investigate the putative association of ischemic stroke with common polymorphisms in ACYP2 and TSPYL6 genes in a Chinese Han population. We found that the risk alleles of six single nucleotide polymorphisms (SNPs), including rs11125529, rs12615793, rs843711, rs11896604, and rs843706 within both ACYP2 and TSPYL6, and rs17045754 in ACYP2 gene, were related with increased risk of ischemic stroke according to both allelic and genotype association analyses. The significant correlations between ACYP2 and TSPYL6 SNPs and ischemic stroke risk were also observed in dominant, recessive, and additive models, respectively. Two blocks in high linkage disequilibrium were identified in this study, and two haplotypes were associated with higher ischemic stroke susceptibility. In conclusion, the genetic polymorphisms of ACYP2 and TSPYL6 are associated with increased risk of developing ischemic stroke. Further studies with larger sample sizes are required to validate our findings.
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.|Shaanxi Provincial Research Center for the Project of Prevention and Treatment of Respiratory Diseases, Xi'an, 710021, People's Republic of China.
Yiqian
Y
Liang
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.|Department of Respiratory Medicine, Hospital of Lantian County, Xi'an, 710500, People's Republic of China.
Rui
R
Zhang
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.
Shuo
S
Zhang
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.|Department of Respiratory Medicine, Xi'an 141 Hospital, Xi'an, 710089, People's Republic of China.
Guofa
G
Ji
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.
Puyu
P
Shi
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.
Tian
T
Yang
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.
Feng
F
Liu
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.
Jing
J
Feng
Department of Internal Medicine, Xi'an International Studies University Hospital, Xi'an, 710061, People's Republic of China.
Chunqi
C
Li
Department of Internal Medicine, Shaanxi Normal University Hospital, Xi'an, 710062, People's Republic of China.
Dangshe
D
Guo
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China. chenmw36@163.com.|Shaanxi Provincial Research Center for the Project of Prevention and Treatment of Respiratory Diseases, Xi'an, 710021, People's Republic of China. chenmw36@163.com.
Mingwei
M
Chen
D017766:Acid Anhydride Hydrolases / Q000235:genetics*; D000368:Aged; D044466:Asian People / Q000235:genetics; D002545:Brain Ischemia / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012306:Risk; D020521:Stroke / Q000235:genetics*; D000097024:Acylphosphatase
D017766:Acid Anhydride Hydrolases; D009687:Nuclear Proteins; C000627904:TSPYL6 protein, human; C000612927:ACYP2 protein, human; D000097024:Acylphosphatase
ACYP2; Ischemic stroke; Single nucleotide polymorphism; TSPYL6; Telomere length
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