Effects of repetitive transcranial magnetic stimulation on non-veridical decision making.
We test the emerging hypothesis that prefrontal cortical mechanisms involved in non-veridical decision making do not overlap with those of veridical decision making. Healthy female subjects performed an experimental task assessing free choice, agent-centered decision making (The Cognitive Bias Task) and a veridical control task related to visuospatial working memory (the Moving Spot Task). Transcranial magnetic stimulation (TMS) was applied to the left and right dorsolateral prefrontal cortex (DLPFC) using 1 Hz and 10 Hz (intermittent) rTMS and sham protocols. Both 1 Hz and 10 Hz stimulation of the DLPFC triggered a shift towards a more context-independent, internal representations driven non-veridical selection bias. A significantly reduced preference for choosing objects based on similarity was detected, following both 1 Hz and 10 Hz treatment of the right as well as 1 Hz rTMS of the left DLPFC. 1 Hz rTMS treatment of the right DLPFC also triggered a significant improvement in visuospatial working memory performance on the veridical task. The effects induced by prefrontal TMS mimicked those of posterior lesions, suggesting that prefrontal stimulation influenced neuronal activity in remote cortical regions interconnected with the stimulation site via longitudinal fasciculi.
University of Tartu, Institute of Psychology, Tartu, Estonia. jaant@ut.ee.
Jaan
J
Tulviste
NYU School of Medicine and Luria Neuroscience Institute, New York, NY, USA.
Elkhonon
E
Goldberg
Houston Methodist Research Institute, Houston, TX, USA.
Kenneth
K
Podell
University of Tartu, Institute of Public Law, Tartu, Estonia.
Talis
T
Bachmann
D000328:Adult; D001703:Biophysics; D003657:Decision Making / Q000502:physiology* / Q000528:radiation effects; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008570:Memory, Short-Term / Q000502:physiology; D008875:Middle Aged; D009039:Motion Perception / Q000502:physiology; D009483:Neuropsychological Tests; D010775:Photic Stimulation; D017397:Prefrontal Cortex / Q000502:physiology* / Q000528:radiation effects; D050781:Transcranial Magnetic Stimulation; D055815:Young Adult