Adiponectin and pro-inflammatory cytokines are modulated in Vietnamese patients with type 2 diabetes mellitus.
OBJECTIVE
Adipose tissue-derived hormones are associated with metabolic disorders including type 2 diabetes mellitus. The present study investigated the levels of adiponectin and pro-inflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin-1 beta (IL-1β) and IL-10 in Vietnamese patients with type 2 diabetes mellitus, and their correlations with clinical parameters of overweight and type 2 diabetes mellitus.


METHODS
Based on body mass index, 73 patients with type 2 diabetes mellitus were categorized either as overweight or non-overweight. As healthy controls, 57 overweight and non-overweight individuals without type 2 diabetes mellitus were included. The adiponectin, TNF-α, IL-1β and IL-10 levels were measured in the sera samples in all study participants by enzyme-linked immunosorbent assay and were correlated with clinical parameters.


RESULTS
The adiponectin levels were lower in patients with type 2 diabetes mellitus (2.5 ± 1.5 μg/mL) compared with controls (16 ± 18.6 μg/mL; P < 0.0001), and were decreased in overweight individuals compared with those who were not overweight. The TNF-α and IL-1β levels were increased, whereas the IL-10 levels were decreased in patients with type 2 diabetes mellitus and in overweight controls compared with non-overweight controls (P < 0.0001). The adiponectin levels were correlated with the TNF-α, IL-1β, IL-10 levels, and the clinical parameters of overweight and type 2 diabetes mellitus. The quantitative insulin sensitivity check index and homeostasis model assessment insulin resistance indexes were correlated with the relative ratios of adiponectin/TNF-α, adiponectin/IL-1β, adiponectin/IL-10, TNF-α/IL-10 and IL-1β/IL-10.


CONCLUSIONS
Adiponectin and pro-inflammatory cytokines are associated with type 2 diabetes mellitus, and might serve as a prognostic marker and a therapeutic intervention for overweight-related type 2 diabetes mellitus.
Department of Pathophysiology, Vietnam Military Medical University, Ha Dong, Hanoi, Vietnam.|Vietnamese-German Center for Medical Research, Hanoi, Vietnam.|Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.
Hoang Van
HV
Tong
103 Military Hospital, Vietnam Military Medical University, Hanoi, Vietnam.
Nguyen Kim
NK
Luu
Department of Pathophysiology, Vietnam Military Medical University, Ha Dong, Hanoi, Vietnam.|Vietnamese-German Center for Medical Research, Hanoi, Vietnam.
Ho Anh
HA
Son
Nghe An Endocrine Hospital, Nghe An, Vietnam.
Nguyen Van
NV
Hoan
Department of Science and Technology for Economic-Technical branches, Ministry of Science and Technology, Hanoi, Vietnam.
Trinh Thanh
TT
Hung
Department of Pathophysiology, Vietnam Military Medical University, Ha Dong, Hanoi, Vietnam.|Vietnamese-German Center for Medical Research, Hanoi, Vietnam.|Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.
Thirumalaisamy P
TP
Velavan
Department of Pathophysiology, Vietnam Military Medical University, Ha Dong, Hanoi, Vietnam.|Vietnamese-German Center for Medical Research, Hanoi, Vietnam.
Nguyen Linh
NL
Toan
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D016753:Interleukin-10 / Q000097:blood; D053583:Interleukin-1beta / Q000097:blood; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014744:Vietnam
C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D016207:Cytokines; C508609:IL10 protein, human; D018836:Inflammation Mediators; D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10
Cytokines; Overweight; Type 2 diabetes mellitus
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