A review on the pharmacological effects of vitexin and isovitexin.
Vitexin and isovitexin are active components of many traditional Chinese medicines, and were found in various medicinal plants. Vitexin (apigenin-8-C-glucoside) has recently received increased attention due to its wide range of pharmacological effects, including but not limited to anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects. Isovitexin (apigenin-6-C-glucoside), an isomer of vitexin, generally purified together with vitexin, also exhibits diverse biological activities. Latest research has suggested that vitexin and isovitexin could be potential substitute medicines for diversity diseases, and may be adjuvants for stubborn diseases or health products. This review summarized recent findings on various pharmacological activities and associative signalling pathways of vitexin and isovitexin to provide a reference for future research and clinical applications.
Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disorder, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, P.R. China.
Miao
M
He
Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disorder, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, P.R. China.
Jia-Wei
JW
Min
Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disorder, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, P.R. China.
Wei-Lin
WL
Kong
Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disorder, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, P.R. China.
Xiao-Hua
XH
He
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, USA.
Jun-Xu
JX
Li
Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disorder, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, P.R. China. Electronic address: pengbiwen@whu.edu.cn.
Bi-Wen
BW
Peng
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D047310:Apigenin / Q000493:pharmacokinetics / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D006801:Humans; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D047310:Apigenin; C032731:vitexin; C049772:isovitexin
Isovitexin; Pharmacological activities; Traditional Chinese medicine; Vitexin