Increased Serum Level of MicroRNA-663 Is Correlated with Poor Prognosis of Patients with Nasopharyngeal Carcinoma.
MicroRNAs (miRs) play crucial roles in the carcinogenesis and malignant progression of human cancers including nasopharyngeal carcinoma (NPC). In this study, we aimed to investigate the association of serum miR-663 levels with the clinical factors and prognosis of NPC patients. Real-time PCR was performed to examine the amount of miR-663 in serum in NPC patients and healthy controls. Our data showed that the amount of miR-663 in serum was significantly higher in NPC patients than in healthy controls. Moreover, the serum levels of miR-663 were significantly correlated with the grade, lymph node metastasis, and clinical stage of NPC. Furthermore, higher serum miR-663 levels were closely associated with worse 5-year overall survival (OS) and relapse-free survival (RFS) of patients with NPC, and the serum level of miR-663 was found to be an independent predicator for the prognosis of NPC. In addition, after receiving chemoradiotherapy, the serum levels of miR-663 were significantly reduced in NPC patients. In summary, miR-663 was upregulated in the serum of NPC patients, which was downregulated after chemoradiotherapy, and its increased levels were closely associated with malignant progression and poor prognosis in NPC patients. Therefore, the amount of miR-663 in serum may become a potential predicator for the clinical outcome of NPC patients.
Department of Radiotherapy, Tumor Hospital of First People's Hospital of Foshan, Foshan, Guangdong 528041, China.
Shaoqiang
S
Liang
Department of Radiotherapy, Tumor Hospital of First People's Hospital of Foshan, Foshan, Guangdong 528041, China.
Ning
0000-0002-2046-3438
N
Zhang
Department of Radiotherapy, Tumor Hospital of First People's Hospital of Foshan, Foshan, Guangdong 528041, China.
Yanming
Y
Deng
Department of Radiotherapy, Tumor Hospital of First People's Hospital of Foshan, Foshan, Guangdong 528041, China.
Lusi
L
Chen
Department of Radiotherapy, Tumor Hospital of First People's Hospital of Foshan, Foshan, Guangdong 528041, China.
Yang
Y
Zhang
Department of Radiotherapy, Tumor Hospital of First People's Hospital of Foshan, Foshan, Guangdong 528041, China.
Zhenhe
Z
Zheng
Department of Radiotherapy, Tumor Hospital of First People's Hospital of Foshan, Foshan, Guangdong 528041, China.
Weijun
W
Luo
Department of Radiotherapy, Tumor Hospital of First People's Hospital of Foshan, Foshan, Guangdong 528041, China.
Zhiqian
Z
Lv
Department of Radiotherapy, Tumor Hospital of First People's Hospital of Foshan, Foshan, Guangdong 528041, China.
Shaoen
S
Li
Department of Radiotherapy, Tumor Hospital of First People's Hospital of Foshan, Foshan, Guangdong 528041, China.
Tao
T
Xun
J Clin Oncol. 2015 Oct 10;33(29):3346-55
26351340
Chin J Cancer Res. 2015 Feb;27(1):1
25717219
Cell Biochem Funct. 2016 Apr;34(3):142-8
26916216
Tumour Biol. 2016 Aug;37(8):11259-66
26951510
J Cell Physiol. 2014 Jul;229(7):834-44
24243035
Oncogene. 2012 Oct 11;31(41):4421-33
22249270
Oncol Rep. 2016 Feb;35(2):1125-34
26717894
Nature. 2004 Sep 16;431(7006):350-5
15372042
Immunol Rev. 2013 May;253(1):129-45
23550643
World J Gastroenterol. 2016 Jan 14;22(2):801-14
26811626
Cancer Med. 2016 Jun;5(6):1163-73
26922862
Mol Cancer. 2015 Feb 13;14:37
25744894
Cell Tissue Res. 2013 Jan;351(1):85-98
23111773
Tumour Biol. 2015 Feb;36(2):871-6
25301444
Expert Rev Proteomics. 2014 Apr;11(2):215-25
24611579
Int J Clin Exp Med. 2015 Aug 15;8(8):13296-302
26550256
Oral Oncol. 2014 Jun;50(6):527-38
24440146
Tumour Biol. 2015 Jan;36(1):69-79
25427638
Br J Cancer. 2013 Jun 11;108(11):2304-11
23695020
Clin Cancer Res. 2015 Sep 1;21(17):4004-13
26023083
J Biol Chem. 2013 Apr 19;288(16):10973-85
23436656
Semin Radiat Oncol. 2012 Jul;22(3):233-44
22687948
Oncotarget. 2015 Sep 22;6(28):26508-18
26164366
Clin Cancer Res. 2014 Apr 1;20(7):1803-13
24523440
Semin Cell Dev Biol. 2016 Feb;50:133-42
26773212
Hematol Oncol Clin North Am. 2015 Dec;29(6):1107-22
26568551
Oncol Rep. 2010 Jul;24(1):105-12
20514450
Semin Diagn Pathol. 2015 Jan;32(1):54-73
25769204
CA Cancer J Clin. 2016 Jan-Feb;66(1):7-30
26742998
Expert Opin Biol Ther. 2007 Jul;7(7):1009-19
17665990
Asian Pac J Cancer Prev. 2011;12(11):2819-23
22393947
J Int Med Res. 2016 Apr;44(2):231-40
26880795
BMC Med Genet. 2013 Jul 19;14:74
23870168
Mol Med Rep. 2016 Apr;13(4):3236-42
26936585