Effect of Coffee in Lipopolysaccharide-Induced Indoleamine 2,3-Dioxygenase Activation and Depressive-like Behavior in Mice.
Research has identified a potential inverse correlation between coffee consumption and the risk of depression. The aim of this study was to investigate the effects of caffeinated coffee on lipopolysaccharide-induced depressive-like behaviors and inflammatory biomarkers in an in vivo model of depression in a C57BL/6J mouse model. The behavioral studies showed that caffeinated coffee decreased immobility time in both the tail suspension test (caffeinated coffee 56.60 ± 9.17; p < 0.0001) and the forced swimming test (caffeinated coffee 28.80 ± 5.93; p < 0.0001), suggesting antidepressant-like activity. The effects of caffeinated coffee on the inflammatory biomarkers associated with depression supported the results observed in the behavioral studies. Statistically significant decreases in indoleamine 2,3-dioxygenase activity (p < 0.001) and the neopterin/biopterin ratio (p < 0.001) were observed in animals pretreated with caffeinated coffee 24 h post-lipopolysaccharide exposure in comparison to the lipopolysaccharide control group. In conclusion, this study has provided evidence to suggest that caffeinated coffee has antidepressant-like activities; however, further studies are required to fully investigate these effects.
Menzies Health Institute Queensland, Griffith University , Queensland 4222, Australia.|School of Pharmacy, Griffith University , Queensland 4222, Australia.
Susan
S
Hall
Menzies Health Institute Queensland, Griffith University , Queensland 4222, Australia.|School of Pharmacy, Griffith University , Queensland 4222, Australia.
Devinder
D
Arora
Menzies Health Institute Queensland, Griffith University , Queensland 4222, Australia.|School of Pharmacy, Griffith University , Queensland 4222, Australia.
Shailendra
S
Anoopkumar-Dukie
Menzies Health Institute Queensland, Griffith University , Queensland 4222, Australia.|School of Pharmacy, Griffith University , Queensland 4222, Australia.
Gary D
GD
Grant
D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage*; D001522:Behavior, Animal; D040503:Coffea / Q000737:chemistry*; D003069:Coffee / Q000737:chemistry; D003863:Depression / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology / Q000523:psychology; D004195:Disease Models, Animal; D019417:Hindlimb Suspension; D006801:Humans; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000235:genetics* / Q000378:metabolism; D008070:Lipopolysaccharides / Q000009:adverse effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010936:Plant Extracts / Q000008:administration & dosage*
D000928:Antidepressive Agents; D003069:Coffee; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D008070:Lipopolysaccharides; D010936:Plant Extracts
coffee; depression; indoleamine 2,3-dioxygenase; inflammation; lipopolysaccharide