Gut microbiota signatures of longevity.
An aging global population poses substantial challenges to society [1]. Centenarians are a model for healthy aging because they have reached the extreme limit of life by escaping, surviving, or delaying chronic diseases [2]. The genetics of centenarians have been extensively examined [3], but less is known about their gut microbiotas. Recently, Biagi et al.[4] characterized the gut microbiota in Italian centenarians and semi-supercentenarians. Here, we compare the gut microbiota of Chinese long-living people with younger age groups, and with the results from the Italian population [4], to identify gut-microbial signatures of healthy aging.
Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China; Department of Animal Science, Division of Agriculture, University of Arkansas, Fayetteville, Arkansas, 72701, USA.
Fanli
F
Kong
Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Yutong
Y
Hua
Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Bo
B
Zeng
Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Ruihong
R
Ning
Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China. Electronic address: yingli@sicau.edu.cn.
Ying
Y
Li
Department of Animal Science, Division of Agriculture, University of Arkansas, Fayetteville, Arkansas, 72701, USA. Electronic address: jzhao77@uark.edu.
Jiangchao
J
Zhao
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D002681:China; D005260:Female; D000069196:Gastrointestinal Microbiome; D006801:Humans; D007558:Italy; D008136:Longevity; D008297:Male; D008875:Middle Aged; D055815:Young Adult