GATA3 rs3824662 gene polymorphism as possible risk factor in a cohort of Egyptian patients with pediatric acute lymphoblastic leukemia and its prognostic impact.
To investigate the possible role of GATA3 rs3824662 polymorphism as risk factor for the development of acute lymphoblastic leukemia (ALL) in a cohort of Egyptian children and to evaluate its prognostic role. Typing of GATA3 rs3824662 polymorphism was done using real-time PCR for 116 patients with ALL and 273 healthy controls. The A allele and AA genotype were significantly higher in ALL patients (p = .015 and .016, respectively) especially B-ALL (p = .014 and .01, respectively). The AA genotype was associated with shorter disease free survival (DFS) in univariate (p = .017) and multivariate cox regression analysis (p = .028), increased incidence of relapse (p = .008) and poor prognosis (p = .028) in pediatric ALL. The GATA3 rs3824662 A allele and AA genotype may be risk factors for the development of pediatric ALL especially B-ALL in the studied cohort of Egyptian patients. The AA genotype is associated with shorter DSF, increased incidence of relapse and poor prognosis in pediatric ALL.
a Clinical Immunology Unit, Clinical Pathology Department & Mansoura Research Center for Cord Stem Cells (MARC_CSC), Faculty of Medicine , Mansoura University , Mansoura , Egypt.
Youssef M
YM
Mosaad
b Hematology/Oncology Unit , Mansoura University Children's Hospital , Mansoura , Egypt.
Rasha
R
Elashery
b Hematology/Oncology Unit , Mansoura University Children's Hospital , Mansoura , Egypt.
Ahmad
A
Darwish
c Clinical Hematology Unit, Clinical Pathology Department, Faculty of Medicine , Mansoura University , Mansoura , Egypt.
Omar A
OA
Sharaf Eldein
d Pediatric Gastroenterology Unit , Mansoura University Children's Hospital , Mansoura , Egypt.
Tarek
T
Barakat
c Clinical Hematology Unit, Clinical Pathology Department, Faculty of Medicine , Mansoura University , Mansoura , Egypt.
Samy
S
Marouf
e Microbiology and Immunology Department , Mansoura Faculty of Medicine , Mansoura , Egypt.
Noha T
NT
Abou El-Khier
f Department of Biochemistry, Faculty of Pharmacy , Mansoura University , Mansoura , Egypt.
Laila F
LF
Youssef
g Laboratory Medicine Department , Mansoura Fever Hospital, Ministry of Health , Mansoura , Egypt.
Iman M
IM
Fawzy
D000483:Alleles; D015415:Biomarkers; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004534:Egypt; D005260:Female; D050990:GATA3 Transcription Factor / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality* / Q000628:therapy; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors
D015415:Biomarkers; D050990:GATA3 Transcription Factor; C494749:GATA3 protein, human
ALL; Egyptian; GATA3 rs3824662; RT-PCR; SNPs