[Sarcopenia and osteoporosis in pulmonary disease.]
Chronic obstructive pulmonary disease(COPD)is a progressive lung disease and its prevalence increases with age. Elderly patients with COPD are known to be at increased risk of sarcopenia and osteoporosis, and this multimorbidity adversely affects progression and prognosis of COPD in parallel. Systemic inflammatory processes and serum biomarkers including cytokines and C-reactive protein might be involved in the underlying pathphyisoplogy for systemic manifestations and multimorbidity of respiratory diseases. In this review, recent insights in the association between respiratory diseases and sarcopenia are introduced, based on the pathophysiology and therapeutic implication of systemic inflammation and age-related muscle wasting.
Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Japan.
Sumito
S
Ogawa
D018450:Disease Progression; D006801:Humans; D007249:Inflammation / Q000150:complications; D010024:Osteoporosis / Q000175:diagnosis* / Q000209:etiology*; D011379:Prognosis; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000175:diagnosis; D055948:Sarcopenia / Q000175:diagnosis / Q000209:etiology*