[The expression of serum miRNAs in pneumoconiosis complicated with pulmonary tuberculosis patients].
Objective:To inquiry the changes of serum miRNAs expression in pneumoconiosis complicated with pulmonary tuberculosis patients.Methods:The study subjects (all subjects are male) were divided into three groups: Ⅰstage pneumoconiosis (38 cases) 、Pneumoconiosis complicated with pulmonary tuberculosis (12 cases) and healthy control (40cases) . The first two groups come from Tianjin worker's sanatorium and healthy control group came from a Hospital Health Screening Center. RT-qPCR was used to detect the expression levels of miR-21, miR-200c, miR-16, miR-204, miR-206, miR-155, let-7g, miR-30b, miR-192, miR-29a in serum.Results:Compared with the healthy control group, the expression levels of miR-204, miR-206, miR-21, miR-16, miR-29a, miR-155, miR-200c in other two groups are different (P<0.05) ; Compared with the Ⅰstage pneumoconiosis, the expression levels of miR-155 is significantly higher (P<0.05) and miR-29a is significantly lower (P<0.05) .Conclusion:Compared with the Ⅰstage pneumoconiosis, the expression levels of miR-155 and miR-29a are significantly different, suggesting that these two miRNAs may play a important role in the process of pneumoconiosis complicated with pulmonary tuberculosis.
Tianjin Centers for Disease Control and Prevention, Tianjin, 300011, China.
Y T
YT
Liu
Q
Q
Zeng
S X
SX
Li
D Y
DY
Yang
W Y
WY
Xing
L M
LM
Feng
M
M
Zhang
D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000378:metabolism*; D011009:Pneumoconiosis / Q000150:complications*; D044967:Serum; D014397:Tuberculosis, Pulmonary / Q000150:complications*
C524942:MIRN155 microRNA, human; C532045:MIRN29a microRNA, human; D035683:MicroRNAs