RICTOR polymorphisms affect efficiency of platinum-based chemotherapy in Chinese non-small-cell lung cancer patients.
We investigated the association between RICTOR polymorphisms and clinical outcomes of platinum-based chemotherapy for Chinese non-small-cell lung cancer patients.



Ten tag SNPs were genotyped in 1004 patients to assess their association with clinical benefit, overall survival, progression-free survival, gastrointestinal toxicity, neutropenia, anemia and thrombocytopenia.



rs6878291 was significantly associated with clinical benefit (odds ratio: 2.037; p = 0.001) and reduced progression-free survival (hazard ratio: 1.461; p = 0.001). Stratified analysis showed that their most significant interaction was in nonsmokers. No association was observed between SNPs and other clinical outcomes.



The study showed evidences for RICTOR polymorphisms' role in platinum-based chemotherapy efficiency, which could provide new insight to lung cancer management.
State Key Laboratory of Genetic Engineering & MOE Key Laboratory of Contemporary Anthropology, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China.
Shiming
S
Wang
State Key Laboratory of Genetic Engineering & MOE Key Laboratory of Contemporary Anthropology, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China.|Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, Shanghai, China.
Xiao
X
Song
State Key Laboratory of Genetic Engineering & MOE Key Laboratory of Contemporary Anthropology, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China.|Shanghai Key Laboratory of Crime SceneEvidence, Shanghai Research Institute of Criminal Science and Technology, Shanghai, China.
Xiaoying
X
Li
State Key Laboratory of Genetic Engineering & MOE Key Laboratory of Contemporary Anthropology, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China.
Xueying
X
Zhao
State Key Laboratory of Genetic Engineering & MOE Key Laboratory of Contemporary Anthropology, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China.
Hongyan
H
Chen
State Key Laboratory of Genetic Engineering & MOE Key Laboratory of Contemporary Anthropology, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China.
Jiucun
J
Wang
State Key Laboratory of Genetic Engineering & MOE Key Laboratory of Contemporary Anthropology, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China.|Department of Pneumology, Changhai Hospital of Shanghai, Second Military Medical University, Shanghai, China.
Junjie
J
Wu
Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
Zhiqiang
Z
Gao
State Key Laboratory of Genetic Engineering & MOE Key Laboratory of Contemporary Anthropology, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China.
Ji
J
Qian
Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
Baohui
B
Han
Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Chunxue
C
Bai
Department of Pneumology, Changhai Hospital of Shanghai, Second Military Medical University, Shanghai, China.
Qiang
Q
Li
State Key Laboratory of Genetic Engineering & MOE Key Laboratory of Contemporary Anthropology, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China.
Daru
D
Lu
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016190:Carboplatin / Q000008:administration & dosage; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000235:genetics / Q000401:mortality; D002352:Carrier Proteins / Q000235:genetics*; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000401:mortality; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D000076226:Rapamycin-Insensitive Companion of mTOR Protein
D002352:Carrier Proteins; C492571:RICTOR protein, human; D000076226:Rapamycin-Insensitive Companion of mTOR Protein; D016190:Carboplatin; D002945:Cisplatin
RICTOR; non-small-cell lung cancer; platinum-based chemotherapy