Adaptation without Plasticity.
Sensory adaptation is a phenomenon in which neurons are affected not only by their immediate input but also by the sequence of preceding inputs. In visual cortex, for example, neurons shift their preferred orientation after exposure to an oriented stimulus. This adaptation is traditionally attributed to plasticity. We show that a recurrent network generates tuning curve shifts observed in cat and macaque visual cortex, even when all synaptic weights and intrinsic properties in the model are fixed. This demonstrates that, in a recurrent network, adaptation on timescales of hundreds of milliseconds does not require plasticity. Given the ubiquity of recurrent connections, this phenomenon likely contributes to responses observed across cortex and shows that plasticity cannot be inferred solely from changes in tuning on these timescales. More broadly, our findings show that recurrent connections can endow a network with a powerful mechanism to store and integrate recent contextual information.
Center for Molecular and Behavioral Neuroscience, Rutgers University-Newark, Newark, NJ 07102, USA; Behavioral and Neural Sciences Graduate Program, Rutgers University-Newark, Newark, NJ 07102, USA.
Maria Del Mar
MDM
Quiroga
Department of Physiology, Neuroscience Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Adam P
AP
Morris
Center for Molecular and Behavioral Neuroscience, Rutgers University-Newark, Newark, NJ 07102, USA. Electronic address: bart@vision.rutgers.edu.
Bart
B
Krekelberg
D000200:Action Potentials / Q000502:physiology; D000222:Adaptation, Physiological; D000818:Animals; D002415:Cats; D008251:Macaca; D008959:Models, Neurological; D009415:Nerve Net / Q000033:anatomy & histology / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000502:physiology; D010364:Pattern Recognition, Visual / Q000502:physiology*; D010775:Photic Stimulation; D013997:Time Factors; D014793:Visual Cortex / Q000033:anatomy & histology / Q000502:physiology*
computational model; network dynamics; neuroscience; orientation; perception; primary visual cortex; recurrent neural network; sensation; sensory processing; vision
Vision Res. 2001 Jan 15;41(2):151-9
11163850
J Neurosci. 2007 Oct 10;27(41):11009-18
17928442
Neuron. 2002 Dec 5;36(5):945-54
12467597
J Neurosci. 2000 Jan 1;20(1):470-84
10627623
J Neurophysiol. 2014 Mar;111(6):1203-13
24371295
Biophys J. 1972 Jan;12(1):1-24
4332108
Neuron. 1998 Jun;20(6):1177-89
9655505
Cortex. 2016 Jul;80:21-34
26856637
Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6172-6
15833815
Front Syst Neurosci. 2013 Mar 06;7:2
23508640
J Neurophysiol. 2012 Jun;107(12):3370-84
22423001
Neural Comput. 2009 Feb;21(2):478-509
19431267
Science. 1999 Aug 27;285(5432):1405-8
10464100
Neuron. 2000 Oct;28(1):287-98
11087001
Vision Res. 1990;30(11):1689-701
2288084
Neuron. 2008 Feb 28;57(4):482-97
18304479
Front Neurosci. 2007 Oct 15;1(1):145-59
18982125
J Comput Neurosci. 1997 Jan;4(1):57-77
9046452
Front Syst Neurosci. 2014 Dec 23;8:239
25565992
Seeing Perceiving. 2011;24(1):37-51
21406154
Neural Comput. 2002 Jul;14(7):1669-89
12079551
Nat Neurosci. 2009 Oct;12(10):1317-24
19749748
J Neurosci. 2012 Jan 4;32(1):308-21
22219292
Nat Neurosci. 2002 Sep;5(9):883-91
12161755
J Neurosci. 2006 Sep 6;26(36):9117-29
16957068
Vision Res. 1982;22(5):531-44
7112953
Curr Opin Neurobiol. 2014 Feb;24(1):95-102
24492085
Nat Rev Neurosci. 2007 Jul;8(7):522-35
17585305
J Neurophysiol. 2003 Apr;89(4):2086-100
12611961
Cereb Cortex. 2002 Feb;12(2):187-98
11739266
J Neurosci. 2000 Jun 1;20(11):4267-85
10818163
J Physiol. 1962 Jan;160:106-54
14449617
Prog Brain Res. 2006;154:93-120
17010705
J Neurosci. 2013 Jan 9;33(2):532-43
23303933
Vis Neurosci. 1999 Nov-Dec;16(6):1115-21
10614591
Curr Opin Neurobiol. 1997 Aug;7(4):514-22
9287203
Neuron. 2001 Oct 25;32(2):315-23
11684000
J Neurophysiol. 2006 Jan;95(1):255-70
16192331
Trends Neurosci. 2006 May;29(5):250-6
16529826
Vision Res. 1997 Nov;37(21):3061-71
9425519
Annu Rev Neurosci. 2000;23:441-71
10845071
Exp Brain Res. 1983;51(1):97-107
6309552
Nature. 2011 May 5;473(7345):87-91
21478872
J Neurosci. 1995 Aug;15(8):5448-65
7643194
Curr Opin Neurobiol. 2011 Aug;21(4):553-8
21646014
Neural Comput. 2000 Nov;12(11):2473-511
11110123