An Excised Canine Model of Anterior Glottic Web and Its Acoustic, Aerodynamic, and High-speed Measurements.
OBJECTIVE
This study aims to build an excised anterior glottic web (AGW) model and study the basic voice-related mechanisms of the AGW through investigating the acoustic, aerodynamic, and vibratory properties.


METHODS
Overall, four conditions were tested for each of the eight canine larynges used. At baseline, 10%, 20%, and 33% occlusion (as determined by the placement of the suture), acoustic, aerodynamic, and high-speed video data were collected while each larynx was phonated in a soundproof booth.


RESULTS
The phonation threshold pressure (PTP) and the phonation threshold flow significantly increased as percent occlusion increased (P < 0.001). There were significant increases in jitter % and shimmer % from baseline group to AGW model groups at PTP, 1.25 PTP, and 1.5 PTP (P = 0.039, P < 0.001, P < 0.001, P < 0.001, P < 0.001, and P = 0.001, respectively). The fundamental frequency significantly increased as percent occlusion increased at all given pressures (P < 0.001). Correlation dimension (D2) was significantly higher in the AGW model groups than in the baseline group at PTP, 1.25 PTP, and 1.5 PTP (P = 0.002, P < 0.001, P = 0.01, respectively). High-speed videos revealed that, the left phase shift in the AGW model groups compared with the baseline at 1.25 PTP was significant (P = 0.027) and right phase shift at 1.5 PTP (P < 0.001).


CONCLUSIONS
We presented an anatomically similar model of a type 1 AGW and confirmed its validity through aerodynamic, acoustic, and high-speed video analysis in our study. We observed and investigated the glottic web movement, which may be a new explanation for the pathologic voice-related mechanism of AGW.
Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, 200031 China; Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792.
Chao
C
Xue
Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792.
Allyson
A
Pulvermacher
Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792.
William
W
Calawerts
Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792.
Erin
E
Devine
Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, 200031 China; Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792. Electronic address: jiang@surgery.wisc.edu.
Jack
J
Jiang
D000162:Acoustics; D000818:Animals; D001696:Biomechanical Phenomena; D000013:Congenital Abnormalities / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D004285:Dogs; D005931:Glottis / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D066298:In Vitro Techniques; D007825:Laryngectomy; D007830:Larynx / Q000002:abnormalities* / Q000473:pathology / Q000503:physiopathology; D023421:Models, Animal; D010699:Phonation; D015203:Reproducibility of Results; D013536:Suture Techniques; D013997:Time Factors; D014732:Vibration; D014741:Video Recording; D014828:Vocalization, Animal
Acoustic; Aerodynamic; Anterior glottic web; Excised larynx; Web movement
Int J Pediatr Otorhinolaryngol. 2005 Jul;69(7):893-6
15911005
Laryngoscope. 2003 Dec;113(12):2187-91
14660925
J Acoust Soc Am. 1992 May;91(5):2926-35
1629485
Biomed Res Int. 2014;2014:464781
24991554
B-ENT. 2006;2(2):51-4
16910287
J Voice. 2010 Nov;24(6):742-9
19850447
J Voice. 2012 Nov;26(6):698-705
22578437
J Voice. 2005 Dec;19(4):519-28
16301098
Biophys J. 1997 Oct;73(4):2164-72
9336212
Ann Otol Rhinol Laryngol. 2010 May;119(5):297-303
20524574
J Voice. 2004 Dec;18(4):454-66
15567047
J Laryngol Otol. 2006 Apr;120(4):322-4
16623977
Laryngoscope. 2009 Dec;119(12):2378-83
19688842
Laryngoscope. 2005 Jun;115(6):1055-9
15933520
Eur Arch Otorhinolaryngol. 2005 Aug;262(8):602-8
16021463
J Voice. 2016 Nov;30(6):664-669
26474718
J Acoust Soc Am. 2010 Jun;127(6):3710-16
20550269
Ann Otol Rhinol Laryngol. 2004 Apr;113(4):277-82
15112969
Chin Med J (Engl). 2014;127(7):1294-7
24709183
J Voice. 2014 Nov;28(6):816-21
24962228
B-ENT. 2010;6(4):261-4
21302688
Laryngoscope. 1993 Aug;103(8):872-82
8361290
Ann Otol Rhinol Laryngol Suppl. 1985 Nov-Dec;121:2-16
3935032
Nihon Jibiinkoka Gakkai Kaiho. 1989 Sep;92(9):1394-8
2585208
Arch Otolaryngol Head Neck Surg. 2005 Aug;131(8):690-5
16103300
Ann Otol Rhinol Laryngol. 2013 Nov;122(11):672-8
24358626
Ann Otol Rhinol Laryngol. 1967 Oct;76(4):744-52
6059212
Acta Otolaryngol. 2015 Aug;135(8):840-5
25828378
J Voice. 1999 Jun;13(2):246-50
10442755