Plant phenyl-propanoids-conjugated silver nanoparticles from edible plant Suaeda maritima (L.) dumort. Inhibit proliferation of K562-human myeloid leukemia cells.
The present study portrays the isolation of four phenylpropanoids - ferulic acid (FA), sinapic acid (SA), caffeic acid (CA), and chlorogenic acid (CHA) from the water extract of Suaeda maritima (L.) Dumort, a phytochemically less explored Indian medicinal plant. Further, synthesis and characterization of silver and gold nanoparticles using the isolated phenylpropanoids were done. The silver nanoparticles synthesized from S. maritima water extract along with silver nano-conjugated forms of the isolated compounds exhibited appreciable anti-leukemic activity against K562 cells (human myeloid leukemia). Especially, the ferulic and CA-conjugated silver nanoparticles showed significant (P < .01) activity against leukemia.
a CARISM, SASTRA University , Thanjavur , India.
Narendran
N
Rajendran
b School of Chemical and Biotechnology, SASTRA University , Thanjavur , India.
Shankar
S
Subramaniam
b School of Chemical and Biotechnology, SASTRA University , Thanjavur , India.
Mamilla R Charan
MRC
Raja
a CARISM, SASTRA University , Thanjavur , India.
Pemaiah
P
Brindha
b School of Chemical and Biotechnology, SASTRA University , Thanjavur , India.
Santanu
S
Kar Mahapatra
b School of Chemical and Biotechnology, SASTRA University , Thanjavur , India.
Aravind
A
Sivasubramanian
D000433:1-Propanol / Q000737:chemistry* / Q000494:pharmacology*; D027703:Amaranthaceae / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D020014:K562 Cells; D007951:Leukemia, Myeloid / Q000473:pathology*; D053768:Metal Nanoparticles / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D010945:Plants, Edible / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*
D000970:Antineoplastic Agents; D012834:Silver; D000433:1-Propanol
Suaeda maritima; XPS; anti-leukemic activity; electron microscopy; nanoparticles