Breaking Hepatitis B Virus Tolerance and Inducing Protective Immunity Based on Mimicking T Cell-Independent Antigen.
There are over 350 million chronic carriers of hepatitis B virus (HBV) in the world, of whom about a third eventually develop severe HBV-related complications. HBV contributes to liver cirrhosis and hepatocellular carcinoma development. Remarkable progress has been made in selective inhibition of HBV replication by nucleoside analogs. However, how to generate protective antibody of HBsAb in HBV-infected patients after HBV-DNA becomes negative still remains a challenge for scientists. In this study, we show that OmpC-HBsAg 'a' epitope chimeric protein vaccine can break HBV tolerance and induce protective immunity in HBV transgenic mice based on mimicking T cell-independent antigen to bypass T cells from the adaptive immune system. The antibodies induced by the vaccine have the ability to prevent HBV virion infection of human hepatocytes.
1 Department of Gastroenterology, Affiliated Hospital of Nantong University , Nantong, China .|2 The Clinical Research Center, Affiliated Hospital of Nantong University , Nantong, China .
Xiaoyan
X
Li
1 Department of Gastroenterology, Affiliated Hospital of Nantong University , Nantong, China .
Runzhou
R
Ni
D056704:Adaptive Immunity; D000818:Animals; D000955:Antigens, T-Independent / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes; D006528:Carcinoma, Hepatocellular / Q000517:prevention & control / Q000821:virology; D005260:Female; D005455:Fluorescent Antibody Technique; D006509:Hepatitis B / Q000150:complications / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D017325:Hepatitis B Vaccines / Q000627:therapeutic use*; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology*; D022781:Hepatocytes / Q000821:virology; D006801:Humans; D007108:Immune Tolerance; D008103:Liver Cirrhosis / Q000517:prevention & control / Q000821:virology; D008113:Liver Neoplasms / Q000517:prevention & control / Q000821:virology; D051379:Mice; D008822:Mice, Transgenic; D011993:Recombinant Fusion Proteins / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000955:Antigens, T-Independent; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D011993:Recombinant Fusion Proteins
HBsAg ‘a’ antigenic determinant; OmpC; T cell-independent antigen; hepatitis B virus