Serendipity in Refractory Celiac Disease: Full Recovery of Duodenal Villi and Clinical Symptoms after Fecal Microbiota Transfer.
Treatment of refractory celiac disease type II (RCD II) and preventing the development of an enteropathy associated T-cell lymphoma in these patients is still difficult. In this case report, we describe a patient with RCD II who received fecal microbiota transfer as treatment for a recurrent Clostridium difficile infection, and remarkably showed a full recovery of duodenal villi and disappearance of celiac symptoms. This case suggests that altering the gut microbiota may hold promise in improving the clinical and histological consequences of celiac disease and/or RCD II.
Dept. of Gastroenterology and Hepatology; Dept. of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands. y.vanbeurden@vumc.nl.
Yvette H
YH
van Beurden
Dept. of Gastroenterology and Hepatology, Amsterdam, The Netherlands.
Tom
T
van Gils
Dept. of Gastroenterology and Hepatology, Canisius Wilhelmina Ziekenhuis, Nijmegen, The Netherlands.
Nienke A
NA
van Gils
Massachusetts Institute of Technology, Cambridge, Massachusetts; OpenBiome, Medford, Massachusetts, USA.
Zain
Z
Kassam
Dept. of Gastroenterology and Hepatology, Amsterdam, The Netherlands.
Chris J J
CJ
Mulder
Dept. of Gastroenterology and Hepatology, Canisius Wilhelmina Ziekenhuis, Nijmegen, The Netherlands.
Nieves
N
Aparicio-Pagés
D000368:Aged; D001284:Atrophy; D002446:Celiac Disease / Q000175:diagnosis / Q000382:microbiology / Q000601:surgery*; D016360:Clostridioides difficile / Q000472:pathogenicity*; D004386:Duodenum / Q000382:microbiology* / Q000473:pathology; D004761:Enterocolitis, Pseudomembranous / Q000175:diagnosis / Q000382:microbiology / Q000601:surgery*; D000069467:Fecal Microbiota Transplantation; D005260:Female; D000069196:Gastrointestinal Microbiome; D006801:Humans; D008871:Microvilli / Q000382:microbiology / Q000473:pathology; D012008:Recurrence; D016896:Treatment Outcome