Resolution of aspergillosis in neuroimaging of an immunocompromised patient with pulmonary and cerebral lesions.
Central nervous system (CNS) aspergillosis is uncommon and considered the most lethal form of aspergillosis. Indeed, current therapeutic strategies such as combination antifungal regimen, neurosurgical resection of infected tissue, and removal of infection source fail to improve the unsatisfactory prognosis of CNS aspergillosis in the majority of the patients. The authors describe a case of chronic pulmonary aspergillosis with concomitant CNS lesions that dramatically responded to antifungal therapy and the CNS lesions resolved in follow-up imaging.
Acquired Immunodeficiency Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Mohsen
M
Meidani
Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Atousa
A
Hakamifard
Department of Radiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Amir Hossein
AH
Sarrami
Aspergillosis; Aspergillus; central nervous system; voriconazole
J Postgrad Med. 2005;51 Suppl 1:S37-41
16519254
Turk Neurosurg. 2011;21(4):641-4
22194129
Thorax. 1991 Jan;46(1):15-20
1871691
Clin Microbiol Infect. 2010 Jul;16(7):870-7
19906275
Clin Infect Dis. 2003 Oct 1;37 Suppl 3:S265-80
12975754
BMC Infect Dis. 2012 Nov 30;12:332
23193986
N Engl J Med. 2009 Apr 30;360(18):1870-84
19403905
Int J Med Sci. 2011;8(7):635-9
22022217