Soluble ST2 and Galectin-3: What We Know and Don't Know Analytically.
The proteins soluble ST2 (sST2) and galectin-3 are currently gaining mounting interest as candidate biomarkers in cardiac disease. Both, sST2 and galectin-3 have been included in the 2013 ACCF/AHA guideline for additive risk stratification of patients with acute and chronic heart failure. The aim of this review is to provide information on analytical considerations of measuring circulating sST2 and galectin-3 including knowledge on in vitro stability, biological variation and reference ranges of both analytes.
Department of Laboratory Medicine, Konventhospital Barmherzige Brueder , Linz, Austria.
Thomas
T
Mueller
Department of Laboratory Medicine, Konventhospital Barmherzige Brueder , Linz, Austria.
Benjamin
B
Dieplinger
biomarkers; cardiac disease; cardiovascular disease; galectins; heart failure; infection; inflammation; interleukin-1 receptor family; interleukin-33; suppression of tumorigenicity 2; transforming growth factor beta superfamily
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