Clinical characteristics of drug-induced liver injury and primary biliary cirrhosis.
OBJECTIVE
To summarize and compare the clinical characteristics of drug-induced liver injury (DILI) and primary biliary cirrhosis (PBC).


METHODS
A total of 124 patients with DILI and 116 patients with PBC treated at Shengjing Hospital Affiliated to China Medical University from 2005 to 2013 were included. Demographic data (sex and age), biochemical indexes (total protein, albumin, alanine aminotransferase, aspartate aminotransferase, total bilirubin, direct bilirubin, indirect bilirubin, alkaline phosphatase, and gamma glutamyltransferase), immunological indexes [immunoglobulin (Ig) A, IgG, IgM, antinuclear antibody, anti-smooth muscle antibody, anti-mitochondrial antibody, and anti-mitochondrial antibodies] and pathological findings were compared in PBC patients, untyped DILI patients and patients with different types of DILI (hepatocellular type, cholestatic type and mixed type).


RESULTS
There were significant differences in age and gender distribution between DILI patients and PBC patients. Biochemical indexes (except ALB), immunological indexes, positive rates of autoantibodies (except SMA), and number of cases of patients with different ANA titers (except the group at a titer of 1:10000) significantly differed between DILI patients and PBC patients. Biochemical indexes, immunological indexes, and positive rate of autoantibodies were not quite similar in different types of DILI. PBC was histologically characterized mainly by edematous degeneration of hepatocytes (n = 30), inflammatory cell infiltration around bile ducts (n = 29), and atypical hyperplasia of small bile ducts (n = 28). DILI manifested mainly as fatty degeneration of hepatocytes (n = 15) and spotty necrosis or loss of hepatocytes (n = 14).


CONCLUSIONS
Although DILI and PBC share some similar laboratory tests (biochemical and immunological indexes) and pathological findings, they also show some distinct characteristics, which are helpful to the differential diagnosis of the two diseases.
Jun Yang, Ya-Li Yu, Yu Jin, Ying Zhang, Chang-Qing Zheng, Division II, Department of Gastroenterology, Shengjing Hospital, China Medical University, Shenyang 110024, Liaoning Province, China.
Jun
J
Yang
Jun Yang, Ya-Li Yu, Yu Jin, Ying Zhang, Chang-Qing Zheng, Division II, Department of Gastroenterology, Shengjing Hospital, China Medical University, Shenyang 110024, Liaoning Province, China.
Ya-Li
YL
Yu
Jun Yang, Ya-Li Yu, Yu Jin, Ying Zhang, Chang-Qing Zheng, Division II, Department of Gastroenterology, Shengjing Hospital, China Medical University, Shenyang 110024, Liaoning Province, China.
Yu
Y
Jin
Jun Yang, Ya-Li Yu, Yu Jin, Ying Zhang, Chang-Qing Zheng, Division II, Department of Gastroenterology, Shengjing Hospital, China Medical University, Shenyang 110024, Liaoning Province, China.
Ying
Y
Zhang
Jun Yang, Ya-Li Yu, Yu Jin, Ying Zhang, Chang-Qing Zheng, Division II, Department of Gastroenterology, Shengjing Hospital, China Medical University, Shenyang 110024, Liaoning Province, China.
Chang-Qing
CQ
Zheng
D000328:Adult; D000367:Age Factors; D000368:Aged; D000974:Antibodies, Antinuclear / Q000276:immunology*; D001652:Bile Ducts / Q000473:pathology; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis*; D002681:China; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D008099:Liver / Q000473:pathology*; D008105:Liver Cirrhosis, Biliary / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012737:Sex Factors
D000974:Antibodies, Antinuclear; D007070:Immunoglobulin A
Autoantibodies; Differential diagnosis; Drug-induced liver injury; Immunoglobulin; Pathological findings; Primary biliary cirrhosis
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