Diabetes in pregnancy and lung health in offspring: developmental origins of respiratory disease.
Diabetes is an increasingly common complication of pregnancy. In parallel with this trend, a rise in chronic lung disease in children has been observed in recent decades. While several adverse health outcomes associated with exposure to diabetes in utero have been documented in epidemiological and experimental studies, few have examined the impact of diabetes in pregnancy on offspring lung health and respiratory disease. We provide a comprehensive overview of current literature on this topic, finding suggestive evidence that exposure to diabetes in utero may have adverse effects on lung development. Delayed lung maturation and increased risk of respiratory distress syndrome have been consistently observed among infants born to mothers with diabetes and these findings are also observed in some rodent models of diabetes in pregnancy. Further research is needed to confirm and characterize epidemiologic observations that diabetes in pregnancy may predispose offspring to childhood wheezing illness and asthma. Parallel translational studies in human pregnancy cohorts and experimental models are needed to explore the role of fetal programming and other potential biological mechanisms in this context.
Manitoba Developmental Origins of Chronic Diseases in Children Network (DEVOTION); Children's Hospital Research Institute of Manitoba, Winnipeg, Canada; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada. Electronic address: meghan.azad@umanitoba.ca.
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MB
Azad
Manitoba Developmental Origins of Chronic Diseases in Children Network (DEVOTION); Children's Hospital Research Institute of Manitoba, Winnipeg, Canada; Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Canada.
B L
BL
Moyce
Manitoba Developmental Origins of Chronic Diseases in Children Network (DEVOTION); Children's Hospital Research Institute of Manitoba, Winnipeg, Canada; Applied Health Sciences, University of Manitoba, Winnipeg, Canada.
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L
Guillemette
Manitoba Developmental Origins of Chronic Diseases in Children Network (DEVOTION); Children's Hospital Research Institute of Manitoba, Winnipeg, Canada; Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada.
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CD
Pascoe
Manitoba Developmental Origins of Chronic Diseases in Children Network (DEVOTION); Children's Hospital Research Institute of Manitoba, Winnipeg, Canada; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada.
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B
Wicklow
Manitoba Developmental Origins of Chronic Diseases in Children Network (DEVOTION); Children's Hospital Research Institute of Manitoba, Winnipeg, Canada; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada.
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JM
McGavock
Manitoba Developmental Origins of Chronic Diseases in Children Network (DEVOTION); Children's Hospital Research Institute of Manitoba, Winnipeg, Canada; Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada.
A J
AJ
Halayko
Manitoba Developmental Origins of Chronic Diseases in Children Network (DEVOTION); Children's Hospital Research Institute of Manitoba, Winnipeg, Canada; Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Canada.
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VW
Dolinsky
D000818:Animals; D001249:Asthma / Q000453:epidemiology / Q000378:metabolism; D001997:Bronchopulmonary Dysplasia / Q000453:epidemiology / Q000378:metabolism; D002648:Child; D016640:Diabetes, Gestational / Q000453:epidemiology* / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D065630:Hernias, Diaphragmatic, Congenital / Q000453:epidemiology / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000196:embryology*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000453:epidemiology* / Q000378:metabolism; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology* / Q000378:metabolism; D012127:Respiratory Distress Syndrome, Newborn / Q000453:epidemiology / Q000378:metabolism; D012135:Respiratory Sounds; D012140:Respiratory Tract Diseases / Q000453:epidemiology* / Q000378:metabolism
asthma; chronic lung disease; developmental origins of health and disease; gestational diabetes; lung development; maternal diabetes; pregnancy; respiratory distress syndrome