Enhancing Extraction of Drug-Drug Interaction from Literature Using Neutral Candidates, Negation, and Clause Dependency.
BACKGROUND
Supervised biomedical relation extraction plays an important role in biomedical natural language processing, endeavoring to obtain the relations between biomedical entities. Drug-drug interactions, which are investigated in the present paper, are notably among the critical biomedical relations. Thus far many methods have been developed with the aim of extracting DDI relations. However, unfortunately there has been a scarcity of comprehensive studies on the effects of negation, complex sentences, clause dependency, and neutral candidates in the course of DDI extraction from biomedical articles.


RESULTS
Our study proposes clause dependency features and a number of features for identifying neutral candidates as well as negation cues and scopes. Furthermore, our experiments indicate that the proposed features significantly improve the performance of the relation extraction task combined with other kernel methods. We characterize the contribution of each category of features and finally conclude that neutral candidate features have the most prominent role among all of the three categories.
NIL Group, Complutense University of Madrid, Ciudad Universitaria, Calle Profesor José García Santesmases, 28040 Madrid, Spain.
Behrouz
B
Bokharaeian
NIL Group, Complutense University of Madrid, Ciudad Universitaria, Calle Profesor José García Santesmases, 28040 Madrid, Spain.
Alberto
A
Diaz
Department of Computer Science, Colorado State University, Fort Collins, Colorado, United States of America.
Hamidreza
H
Chitsaz
D000465:Algorithms; D001185:Artificial Intelligence; D035843:Biomedical Research; D057225:Data Mining; D004347:Drug Interactions; D006801:Humans; D009323:Natural Language Processing; D011642:Publications
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