Comparison of diagnostic accuracies of two- and three-dimensional MR elastography of the liver.
To evaluate the effect of imaging sequence (spin-echo echo-planar imaging [EPI] and gradient-echo [GRE]) and postprocessing method (two-dimensional [2D] and 3D inversion algorithms) on liver MR elastography (MRE) and to validate the diagnostic performance of EPI-MRE3Dversus conventional GRE-MRE2Dfor liver fibrosis staging.



Three MRE methods (EPI-MRE3D, EPI-MRE2D, and GRE-MRE2D) were performed on soft and mildly stiff phantoms and 58 patients with chronic liver disease using a 3 Tesla clinical MRI scanner, and stiffness values were compared among the three methods. A validation study comprised 73 patients with histological liver fibrosis (F0-4, METAVIR system). Areas under the receiver operating characteristic curves (AUCs) and accuracies for diagnosing significant fibrosis (F3-4) and cirrhosis (F4) were compared between EPI-MRE3Dand GRE-MRE2D.



Stiffness values of the soft and mildly stiff phantoms were 2.4 kPa and 4.0 kPa by EPI-MRE3D; 2.6 kPa and 4.2 kPa by EPI-MRE2D; and 2.7 kPa and 4.2 kPa by GRE-MRE2D. In patients, EPI-MRE3Dprovided significantly lower stiffness values than other methods (P < 0.001). However, there was no significant difference between GRE-MRE2Dand EPI-MRE2D(P = 0.12). The AUCs and accuracies of EPI-MRE3Dand GRE-MRE2Dwere statistically equivalent in the diagnoses of significant fibrosis (F3-4) and cirrhosis (F4) (all P < 0.005).



EPI-MRE3Dshowed modestly lower liver stiffness values than conventional GRE-MRE2D. The diagnostic performances of EPI-MRE3Dand GRE-MRE2Dwere equivalent for liver fibrosis staging.



3 J. Magn. Reson. Imaging 2017;45:1163-1170.
Department of Radiology, University of Yamanashi, Yamanashi, Japan.|Department of Diagnostic Radiology, Saitama Medical University International Medical Center, Saitama, Japan.
Hiroyuki
0000-0002-5776-6280
H
Morisaka
Department of Radiology, University of Yamanashi, Yamanashi, Japan.
Utaroh
U
Motosugi
Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Kevin J
KJ
Glaser
Department of Radiology, University of Yamanashi, Yamanashi, Japan.
Shintaro
S
Ichikawa
Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Richard L
RL
Ehman
Department of Radiology, University of Yamanashi, Yamanashi, Japan.|Department of Diagnostic Radiology, Saitama Medical University International Medical Center, Saitama, Japan.
Katsuhiro
K
Sano
Department of Radiology, University of Yamanashi, Yamanashi, Japan.|Department of Diagnostic Radiology, Saitama Medical University International Medical Center, Saitama, Japan.
Tomoaki
T
Ichikawa
Department of Radiology, University of Yamanashi, Yamanashi, Japan.
Hiroshi
H
Onishi
D000368:Aged; D000369:Aged, 80 and over; D017352:Echo-Planar Imaging / Q000379:methods; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008099:Liver / Q000000981:diagnostic imaging; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging* / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012189:Retrospective Studies
echo planar imaging (EPI); gradient-echo imaging (GRE); liver fibrosis staging; magnetic resonance elastography (MRE); three-dimensional postprocessing
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