Fractionated Gamma Knife surgery for giant pituitary adenomas.
OBJECTIVE
To analyze the feasibility and effectiveness of fractionated Gamma Knife surgery (FGKS) for giant pituitary adenomas.


METHODS
From June 2005 to May 2016, 14 patients with giant pituitary adenomas were treated with FGKS, and 10 patients (71%) completed follow-up evaluation. All patients had undergone surgical resection at least once prior to FGKS. The median-volume of the adenomas was 17.6cm3(range 4.9-61cm3).


RESULTS
The median follow-up period was 31.5 months (range 6-58 months). The size of the tumors decreased in 6 patients and remained stable in 4 patients. The visual acuity improved in 1 patient. None of the patients suffered from vision deterioration caused by FGKS.


CONCLUSIONS
FGKS is an effective treatment modality for giant pituitary adenomas in selected patients.
Gamma Knife Center, Department of Neurosurgery, The 2nd Hospital of Tianjin Medical University, Tianjin, China.
Kai
K
Zhao
Gamma Knife Center, Department of Neurosurgery, The 2nd Hospital of Tianjin Medical University, Tianjin, China. Electronic address: liuxiaomin@tmu.edu.cn.
Xiaomin
X
Liu
Gamma Knife Center, Department of Neurosurgery, The 2nd Hospital of Tianjin Medical University, Tianjin, China.
Dong
D
Liu
Gamma Knife Center, Department of Neurosurgery, The 2nd Hospital of Tianjin Medical University, Tianjin, China.
Yanhe
Y
Li
Gamma Knife Center, Department of Neurosurgery, The 2nd Hospital of Tianjin Medical University, Tianjin, China.
Zhiyuan
Z
Zhang
Gamma Knife Center, Department of Neurosurgery, The 2nd Hospital of Tianjin Medical University, Tianjin, China.
Yiguang
Y
Lin
Gamma Knife Center, Department of Neurosurgery, The 2nd Hospital of Tianjin Medical University, Tianjin, China.
Yipei
Y
Zhang
Gamma Knife Center, Department of Neurosurgery, The 2nd Hospital of Tianjin Medical University, Tianjin, China.
Desheng
D
Xu
D000236:Adenoma / Q000000981:diagnostic imaging / Q000628:therapy*; D000328:Adult; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D010911:Pituitary Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*; D016634:Radiosurgery / Q000379:methods*
Gamma Knife; Giant pituitary adenoma; Radiosurgery; Stereotactic radiosurgery