Correlations of PTEN genetic polymorphisms with the risk of depression and depressive symptoms in a Chinese population.
OBJECTIVE
This study aimed to investigate the correlations of three common single nucleotide polymorphisms (SNPs) in the PTEN gene (rs701848 T>C, rs2735343 G>C and rs112025902 A>T) with the risk of depression and depressive symptoms in a Chinese population.


METHODS
From July 2011 to June 2013, a total of 384 patients with depression and 400 healthy individuals were included in this study. These SNPs in the PTEN gene were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and direct sequencing. The Hamilton Depression Rating Scale (HAMD) was used to evaluate the severity of depression.


RESULTS
The C allele of rs701848, the C allele of rs2735343 and the T allele of rs112025902 were associated with an increased risk of depression (odds ratio [OR]=3.814, 95% CI: 3.093-4.703, P<0.001; OR=2.642, 95% CI: 2.152-3.242, P<0.001; OR=2.882, 95% CI: 2.347-3.539, P<0.001; respectively). Depression patients carrying C allele (TC+CC) of rs701848 and carrying T allele (AT+TT) of rs112025902 had higher HAMD total scores and HAMD anxiety factor scores than those carrying TT genotype of rs701848 and carrying AA genotype of rs112025902 (all P<0.05). Furthermore, depression patients carrying C allele (GC+CC) of rs2735343 had lower HAMD total scores and HAMD factors associated with depression scores than those carrying GG genotype (both P<0.05). Logistic regression analysis revealed that rs701848, rs2735343 and rs112025902 polymorphisms in the PTEN gene may be independent risk factors of depression (relative risk [RR]=1.807, 95% CI=1.023-3.193, P=0.042; RR=1.759, 95% CI=1.033-2.995, P=0.038; RR=1.646, 95% CI=1.018-2.663, P=0.042; respectively).


CONCLUSIONS
Our findings provide evidence that rs701848, rs2735343 and rs112025902 polymorphisms in the PTEN gene may be correlated with the risk of depression and depressive symptoms in the Chinese population.
Wenzhou Kangning Hospital, Wenzhou Medical University, Wenzhou 325000, PR China. Electronic address: liulinjing50@163.com.
Lin-Jing
LJ
Liu
Wenzhou Kangning Hospital, Wenzhou Medical University, Wenzhou 325000, PR China.
Cheng
C
Zhu
Wenzhou Kangning Hospital, Wenzhou Medical University, Wenzhou 325000, PR China.
Hai-Jia
HJ
Tian
Wenzhou Kangning Hospital, Wenzhou Medical University, Wenzhou 325000, PR China.
Tian-Sheng
TS
Zheng
Wenzhou Kangning Hospital, Wenzhou Medical University, Wenzhou 325000, PR China.
Min-Jie
MJ
Ye
Institute of Wenzhou Kangning Mental Health, Wenzhou Kangning Hospital, Wenzhou Medical University, Wenzhou 325000, PR China.
Hui
H
Li
D000328:Adult; D000483:Alleles; D002681:China; D003863:Depression / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D051059:PTEN Phosphohydrolase / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human
Depression; Depressive symptoms; Genetic polymorphisms; Hamilton Depression Rating Scale; PTEN; Risk factor