Dyslipidemia: Obese or Not Obese-That Is Not the Question.
OBJECTIVE
Purpose of review: It is becoming increasingly clear that some obese individuals do not develop dyslipidemia and instead remain healthy, while some normal weight individuals become dyslipidemic and unhealthy.


RESULTS
The present review examines the similarities and differences between healthy and unhealthy individuals with and without obesity and discusses putative underlying mechanisms of dyslipidemia. The presence of dyslipidemia and compromised metabolic health in both lean and obese individuals suggests that the obese phenotype per se does not represent a main independent risk factor for the development of dyslipidemia and that dyslipidemia, rather than obesity, may be the driver of metabolic diseases. Notably, adipose tissue dysfunction and ectopic lipid deposition, in particular in the liver, seems a common trait of unhealthy individuals.
Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Ridebanevej 9, 1870, Frederiksberg C, Denmark.
David H
DH
Ipsen
Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Ridebanevej 9, 1870, Frederiksberg C, Denmark.
Pernille
P
Tveden-Nyborg
Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Ridebanevej 9, 1870, Frederiksberg C, Denmark. jopl@sund.ku.dk.
Jens
J
Lykkesfeldt
D000273:Adipose Tissue / Q000378:metabolism; D050171:Dyslipidemias / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D004734:Energy Metabolism / Q000502:physiology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008055:Lipids / Q000097:blood*; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000503:physiopathology
D008055:Lipids
Dyslipidemia; Metabolically healthy obese; Metabolically unhealthy normal weight; Metabolically unhealthy obese; Obesity
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