Reproductive outcomes of familial oocyte donation.
OBJECTIVE
Oocyte donation (OD) from a family member may be more available to patients. Our objective was to compare reproductive outcomes of familial OD with those of unrelated OD.


METHODS
Retrospective cohort study in a single university-affiliated center.


METHODS
Not applicable.


METHODS
Four hundred thirty OD cycles performed from 2010 to 2014: 124 from family members and 306 from unrelated donors.


METHODS
None.


METHODS
Ovarian stimulation parameters and cycle outcomes (total gonadotropin dose, number of retrieved oocytes, number of embryos, number of vitrified embryos, blastocyst transfer rate, rate of fresh transfers); endometrial preparation parameters; implantation, clinical pregnancy, miscarriage, and live birth rates; perinatal outcomes (gestational age at birth, birth weight, delivery mode, cesarean delivery rates).


RESULTS
Implantation, clinical pregnancy, miscarriage, and live birth rates were similar between familial OD cycles and unrelated OD cycles (32.9% vs. 39.7%, 41.9% vs. 44.4%, 30.7% vs. 30.9%, and 29% vs. 28.7%, respectively). Gestational age at birth and birth weight were similar (37.8 wk ± 2.2 d vs. 37.1 wk ± 3 d and 3,043 ± 722 g vs. 2,906 ± 788 g, respectively). Similar outcomes were also found in single-embryo transfer OD cycles (live birth rate 26.7% vs. 24.2%). Sister-to-sister OD cycles outcomes were similar to those of unrelated donors.


CONCLUSIONS
The reproductive outcomes of familial OD are similar to those of unrelated OD. These findings are in contrast to previous presumptions regarding the efficiency of familial OD and may help in the counseling of women who need OD.
Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada. Electronic address: y.r.hasson@gmail.com.
Joseph
J
Hasson
Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
Togas
T
Tulandi
Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
Weon-Yong
WY
Son
Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
Na'ama
N
Al Ma'mari
Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
Ahmad
A
Badeghiesh
Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
Sammer
S
Tannus
Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
Janet
J
Takefman
Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
Tal
T
Shavit
D000022:Abortion, Spontaneous / Q000209:etiology; D000328:Adult; D016009:Chi-Square Distribution; D010064:Embryo Implantation; D004624:Embryo Transfer; D005190:Family; D005260:Female; D005298:Fertility; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D050498:Live Birth; D019520:Living Donors; D016015:Logistic Models; D015999:Multivariate Analysis; D018587:Oocyte Donation / Q000009:adverse effects; D054315:Oocyte Retrieval; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D016649:Primary Ovarian Insufficiency / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D061349:Unrelated Donors; D055815:Young Adult
Oocyte donation; family members; premature ovarian insufficiency; reproductive outcome; siblings