Effects of GABA on the expression of type I collagen gene in normal human dermal fibroblasts.
We examined the effects of GABA on type I collagen gene expression in normal human dermal fibroblasts. Real-time PCR analysis indicated GABA increased the level of type I collagen transcripts, and suppressed the expression of matrix metalloproteinase-1, which is a collagen-degrading enzyme. These results suggest GABA improves the skin elasticity by regulating type I collagen expression.
a Sanwa Shurui Co. Ltd. , Usa , Japan.
Eriko
E
Uehara
a Sanwa Shurui Co. Ltd. , Usa , Japan.
Hideki
H
Hokazono
b Faculty of Medicine, Department of Matrix Medicine , Oita University , Yufu , Japan.
Takako
T
Sasaki
b Faculty of Medicine, Department of Matrix Medicine , Oita University , Yufu , Japan.
Hidekatsu
H
Yoshioka
b Faculty of Medicine, Department of Matrix Medicine , Oita University , Yufu , Japan.
Noritaka
N
Matsuo
D024042:Collagen Type I / Q000235:genetics*; D000090602:Collagen Type I, alpha 1 Chain; D005347:Fibroblasts / Q000187:drug effects* / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012867:Skin / Q000166:cytology*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D024042:Collagen Type I; D000090602:Collagen Type I, alpha 1 Chain; D012333:RNA, Messenger; D005680:gamma-Aminobutyric Acid; D020781:Matrix Metalloproteinase 1
GABA; MMP-1; collagen; normal human dermal fibroblasts