Association of body mass index and waist circumference with severity of knee osteoarthritis.
OBJECTIVE
The aim of the present study was to investigate the association of the body mass index (BMI) and waist circumference (WC) with the severity of radiographic severity of knee osteoarthritis (rKOA) Methods. A cross-sectional study had been applied during the research which included 150 patients diagnosed at the General Hospital in Užice and Health Center in Arilje (Serbia). The study included patients over the age of 50 diagnosed with OA according to The European League Against Rheumatism (EULAR) criteria. Data on social-demographic characteristics, health habits, and personal and family histories of the participants were collected through a specific questionnaire designated for this research. The severity of the disease was assessed pursuant to radiological changes using the Кellgren-Lawrence grading scale (K-L). The state of nourishment was assessed according to the BMI and WC.


RESULTS
According to multivariate logistic regression analyses, after adjustment on age, sex, marital status, formal education, present occupation, smoking, alcohol consumption and physical activity, higher grades of rKOA (grade III and grade IV) were significantly related to BMI (p = 0.038) and WC (p < 0.001). The association was much stronger for obesity defined as BMI ≥30 kg/m2 (p = 0.002) and for abdominal obesity - WC > 102 cm in men and > 88 cm in women (p = 0.009).


CONCLUSIONS
This study showed that obesity defined as BMI ≥30 kg/m2 and abdominal obesity are strongly related to K-L of rKOA, the associations being of very similar extent.
S
S
Vasilic-Brasnjevic
J
J
Marinkovic
H
H
Vlajinac
N
N
Vasiljevic
B
B
Jakovljevic
M
M
Nikic
M
M
Maksimovic
D000368:Aged; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D020370:Osteoarthritis, Knee / Q000150:complications / Q000000981:diagnostic imaging*; D012720:Severity of Illness Index; D055105:Waist Circumference