An Electrophilic Reagent for the Direct Introduction of the SCF2PO(OEt)2Group to Molecules.
An unprecedented electrophilic difluoromethylthiolating reagent (MesNHSCF2PO(OEt)2) was designed. Under mild and metal-free conditions, this new reagent reacted with various nucleophiles, thus offering an efficient and operationally simple tool for the construction of C-SCF2PO(OR)2, N-SCF2PO(OR)2, and S-SCF2PO(OR)2bonds. Finally, thanks to this new methodology, the synthesis of the non-stereoidal anti-inflammatory diflumidone was achieved.
Normandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000, Rouen, France.
Heng-Ying
0000-0003-0726-524X
HY
Xiong
Normandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000, Rouen, France.
Alexandre
0000-0003-3506-0524
A
Bayle
Normandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000, Rouen, France.
Xavier
0000-0002-4598-7895
X
Pannecoucke
Normandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000, Rouen, France. tatiana.besset@insa-rouen.fr.
Tatiana
0000-0003-4877-5270
T
Besset
difluoromethylthiolation; electrophilic reagents; fluorine; sulfur; synthetic methods