MicroRNA and Long Non-Coding RNA in Ovarian Carcinoma: Translational Insights and Potential Clinical Applications.
Reliable biomarkers for the detection of early ovarian carcinoma are currently unavailable. MicroRNA and long non-coding RNA may be important in cancer initiation and progression by regulating gene expression through post-transcriptional mechanisms. MicroRNAs, such as miR-26a and miR-132, have been investigated as novel biomarkers for diagnosis, prognosis, monitoring of therapeutic response, and therapeutic targets in ovarian carcinomas. Some long non-coding RNAs, such as H19 and UCA1, may be involved in the pathogenesis of ovarian carcinomas. MicroRNA and long non-coding RNA have potential clinical utility in the diagnosis of ovarian cancer and predicting prognosis, metastasis, recurrence, and response to therapy.
a Department of Clinical Laboratory , Women's Hospital, School of Medicine, Zhejiang University , China.
Yu
Y
Ma
b Institute of Translational Medicine, School of Medicine , Zhejiang University , China.
Yan
Y
Lu
c Department of Surgical Pathology , Women's Hospital, School of Medicine, Zhejiang University , China.
Bingjian
B
Lu
D000818:Animals; D014408:Biomarkers, Tumor; D018450:Disease Progression; D004734:Energy Metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000097:blood / Q000235:genetics*; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000401:mortality / Q000628:therapy; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000235:genetics*; D015398:Signal Transduction; D057170:Translational Research, Biomedical
D014408:Biomarkers, Tumor; D035683:MicroRNAs; D062085:RNA, Long Noncoding
Ovarian carcinoma; biomarkers; long non-coding RNA; microRNA