α-Glucosidase Inhibitors from Preussia minimoides ‡.
Extensive fractionation of an extract from the grain-based culture of the endophytic fungus Preussia minimoides led to the isolation of two new polyketides with novel skeletons, minimoidiones A (1) and B (2), along with the known compounds preussochromone C (3), corymbiferone (4), and 5-hydroxy-2,7-dimethoxy-8-methylnaphthoquinone (5). The structures of 1 and 2 were elucidated using 1D and 2D NMR data analysis, along with DFT calculations of1H NMR chemical shifts. The absolute configuration of 1 was established by a single-crystal X-ray diffraction analysis and TDDFT-ECD calculations. Compounds 1-4 significantly inhibited yeast α-glucosidase.
Facultad de Química, Universidad Nacional Autónoma de México , Ciudad de México 04510, México.
Manuel
M
Rangel-Grimaldo
Facultad de Química, Universidad Nacional Autónoma de México , Ciudad de México 04510, México.
Isabel
I
Rivero-Cruz
Facultad de Química, Universidad Nacional Autónoma de México , Ciudad de México 04510, México.
Abraham
A
Madariaga-Mazón
Facultad de Química, Universidad Nacional Autónoma de México , Ciudad de México 04510, México.
Mario
M
Figueroa
Facultad de Química, Universidad Nacional Autónoma de México , Ciudad de México 04510, México.
Rachel
R
Mata
D000465:Algorithms; D001203:Ascomycota / Q000737:chemistry*; D018360:Crystallography, X-Ray; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008800:Mexico; D008968:Molecular Conformation; D015394:Molecular Structure; D009285:Naphthoquinones; D019906:Nuclear Magnetic Resonance, Biomolecular; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000520:alpha-Glucosidases / Q000187:drug effects*
C000589060:5-hydroxy-2,7-dimethoxy-8-methylnaphthoquinone; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D009285:Naphthoquinones; D061065:Polyketides; C000621205:minimoidione A; C000621206:minimoidione B; D000520:alpha-Glucosidases