Domino Staudinger/aza-Wittig/Mannich Reaction: An Approach to Diversity of Di- and Tetrahydropyrrole Scaffolds.
A highly efficient and selective domino reaction producing valuable di- and tetrahydropyrrole-based skeletons from azidoethyl-substituted CH-acids and (thio)carbonyl compounds has been developed. By involving the additional functional groups in starting compounds into the domino reaction or postmodification of the primary reaction products, the simple construction of the pharmaceutically relevant three- and polycyclic azaheterocyclic scaffolds was demonstrated.
Department of Chemistry, M. V. Lomonosov Moscow State University, Leninskie Gory, 1-3, Moscow, 119991, Russian Federation.
Anna S
AS
Pavlova
Department of Chemistry, M. V. Lomonosov Moscow State University, Leninskie Gory, 1-3, Moscow, 119991, Russian Federation.|Laboratory of Chemical Synthesis, Federal Research Center of Pediatric Hematology, Oncology and Immunology n.a. Dmitriy Rogachev, Samory Mashela st., 1, Moscow, 117997, Russian Federation.
Olga A
http://orcid.org/0000-0002-1651-4001
OA
Ivanova
Laboratory of Chemical Synthesis, Federal Research Center of Pediatric Hematology, Oncology and Immunology n.a. Dmitriy Rogachev, Samory Mashela st., 1, Moscow, 117997, Russian Federation.|Faculty of Science, Russian University of People's Friendship, Miklukho-Maklaya 6, Moscow, 117198, Russian Federation.
Alexey O
http://orcid.org/0000-0002-7590-3541
AO
Chagarovskiy
Department of Chemistry, M. V. Lomonosov Moscow State University, Leninskie Gory, 1-3, Moscow, 119991, Russian Federation.
Nikolay S
NS
Stebunov
Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky pr. 47, Moscow, 119991, Russian Federation.
Nikolay V
NV
Orlov
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Kosygina 4, Moscow, 119334, Russian Federation.
Alexey N
AN
Shumsky
Department of Chemistry, M. V. Lomonosov Moscow State University, Leninskie Gory, 1-3, Moscow, 119991, Russian Federation.
Ekaterina M
EM
Budynina
Department of Chemistry, M. V. Lomonosov Moscow State University, Leninskie Gory, 1-3, Moscow, 119991, Russian Federation.
Victor B
VB
Rybakov
Laboratory of Chemical Synthesis, Federal Research Center of Pediatric Hematology, Oncology and Immunology n.a. Dmitriy Rogachev, Samory Mashela st., 1, Moscow, 117997, Russian Federation.|Faculty of Science, Russian University of People's Friendship, Miklukho-Maklaya 6, Moscow, 117198, Russian Federation.
Igor V
http://orcid.org/0000-0002-1614-416X
IV
Trushkov
azides; domino reactions; donor-acceptor cyclopropanes; nitrogen heterocycles; synthesis design