INFLAMMATORY DISORDERS ASSOCIATED WITH HELICOBACTER PYLORI IN THE ROUX-EN-Y BYPASS GASTRIC POUCH.
The prevalence of Helicobacter pylori in obese candidates for bariatric surgery and its role in the emergence of inflammatory lesions after surgery has not been well established.



To identify the incidence of inflammatory lesions in the stomach after bariatric surgery and to correlate it with H. pylori infection.



This is a prospective study with 216 patients undergoing Roux-en-Y gastric bypass. These patients underwent histopathological endoscopy to detect H. pylori prior to surgery. Positive cases were treated with antibiotics and a proton inhibitor pump followed by endoscopic follow-up in the 6th and 12th month after surgery.



Most patients were female (68.1%), with grade III obesity (92.4%). Preoperative endoscopy revealed gastritis in 96.8%, with H. pylori infection in 40.7% (88/216). A biopsy was carried out in 151 patients, revealing H. pylori in 60/151, related to signs of inflammation in 90% (54/60). In the 6th and 12th month after surgery, the endoscopy and the histopathological exam showed a normal gastric pouch in 84% of patients and the incidence of H. pylori was 11% and 16%, respectively. The presence of inflammation was related to H. pylori infection (p<0,001).



H. pylori has a similar prevalence in both obese patients scheduled to undergo bariatric surgery and the general population. There is a low incidence of it in the 6th and 12th months after surgery, probably owing to its eradication when detected prior to surgery. When inflammatory disease is present in the new gastric reservoir it is directly related to H. pylori infection.
Postgradute Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém, PA, Brazil.
Luiz Claudio Lopes
LC
Chaves
Postgradute Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém, PA, Brazil.
Isabela Klautau Leite Chaves
IK
Borges
Postgradute Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém, PA, Brazil.
Maíra Danielle Gomes de
MD
Souza
Postgradute Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém, PA, Brazil.
Ian Passos
IP
Silva
Postgradute Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém, PA, Brazil.
Lyz Bezerra
LB
Silva
Postgradute Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém, PA, Brazil.
Marcelo Alexandre Prado
MA
Magalhães
Postgradute Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém, PA, Brazil.
Allan Herbert Feliz
AH
Fonseca
Postgradute Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém, PA, Brazil.
Josemberg Marins
JM
Campos
Surg Obes Relat Dis. 2013 Sep-Oct;9(5):760-4
22951079
Arq Bras Cir Dig. 2015;28 Suppl 1:39-42
26537272
Endocr Pract. 2013 Mar-Apr;19(2):337-72
23529351
Arq Bras Cir Dig. 2015 Apr-Jun;28(2):139-43
26176254
Obes Surg. 2013 Jun;23(6):736-9
23585025
Surg Obes Relat Dis. 2008 May-Jun;4(3):383-8
17974495
World J Gastroenterol. 2014 Jan 21;20(3):647-53
24574738
Saudi J Gastroenterol. 2010 Oct-Dec;16(4):264-7
20871190
Obes Surg. 2013 Oct;23(10):1616-23
24022341
Surg Endosc. 2009 Nov;23(11):2531-4
19444517
Arq Bras Cir Dig. 2016 Mar;29(1):33-7
27120737
Arq Gastroenterol. 2005 Apr-Jun;42(2):128-32
16127570
Arq Gastroenterol. 2012 Jan-Mar;49(1):52-5
22481686
Surg Obes Relat Dis. 2013 Sep-Oct;9(5):679-85
23246321
Turk J Gastroenterol. 2014 Dec;25 Suppl 1:157-61
25910297
Acta Chir Belg. 2013 Jul-Aug;113(4):249-53
24224432
Surg Obes Relat Dis. 2015 Mar-Apr;11(2):303-7
25541111