Advances in nanomaterials and their applications in point of care (POC) devices for the diagnosis of infectious diseases.
Nanotechnology has gained much attention over the last decades, as it offers unique opportunities for the advancement of the next generation of sensing tools. Point-of-care (POC) devices for the selective detection of biomolecules using engineered nanoparticles have become a main research thrust in the diagnostic field. This review presents an overview on how the POC-associated nanotechnology, currently applied for the identification of nucleic acids, proteins and antibodies, might be further exploited for the detection of infectious pathogens: although still premature, future integrations of nanoparticles with biological markers that target specific microorganisms will enable timely therapeutic intervention against life-threatening infectious diseases.
Pharmacy Department National University of Singapore, Singapore 117543, Singapore. Electronic address: tram.dai.thien.nhan@u.nus.edu.
Dai Thien Nhan
DT
Tram
Department of Electrical and Computer Engineering, National University of Singapore, 4 Engineering, Drive 3, Singapore 117576, Singapore. Electronic address: elewangh@nus.edu.sg.
Hao
H
Wang
Department of Chemistry, National University of Singapore, Singapore 117543, Singapore. Electronic address: sigit.sugiarto@u.nus.edu.
Sigit
S
Sugiarto
Department of Chemistry, National University of Singapore, Singapore 117543, Singapore. Electronic address: litao@u.nus.edu.
Tao
T
Li
Department of Chemistry, National University of Singapore, Singapore 117543, Singapore. Electronic address: chmawh@nus.edu.sg.
Wee Han
WH
Ang
Department of Electrical and Computer Engineering, National University of Singapore, 4 Engineering, Drive 3, Singapore 117576, Singapore. Electronic address: elelc@nus.edu.sg.
Chengkuo
C
Lee
Pharmacy Department National University of Singapore, Singapore 117543, Singapore; NanoCore, Faculty of Engineering, National University of Singapore, Singapore 117576, Singapore; NUS Graduate School for Integrative Sciences and Engineering, Centre for Life Sciences (CeLS), Singapore 117456, Singapore. Electronic address: phapg@nus.edu.sg.
Giorgia
G
Pastorin
D003141:Communicable Diseases / Q000175:diagnosis*; D006801:Humans; D050997:Nanomedicine / Q000379:methods*; D049329:Nanostructures / Q000737:chemistry / Q000627:therapeutic use; D019095:Point-of-Care Systems
Diagnostic tools; Infectious diseases; Nanotechnology; Pathogens; Point-of-care (POC)
Adv Mater. 2013 Jan 4;25(1):142-9
23397611
Biosens Bioelectron. 2010 Mar 15;25(7):1658-62
20022741
Nucleic Acids Res. 2004 Oct 21;32(18):e141
15498924
Hygie. 1993 Jun;12(2):5-11, 45-6
8325665
Science. 2015 Mar 13;347(6227):1240-2
25766232
Anal Chem. 2012 Apr 3;84(7):3200-7
22390751
Expert Rev Mol Diagn. 2007 Nov;7(6):703-7
18020900
Biosens Bioelectron. 2003 Apr;18(4):405-13
12604258
Biosens Bioelectron. 2003 Oct 15;18(12):1501-8
12941566
Angew Chem Int Ed Engl. 2008;47(14):2590-4
18228547
Nucleic Acids Res. 2006;34(18):e118
17000638
Biosens Bioelectron. 2003 Nov 30;19(3):177-83
14611752
Chemistry. 2008;14(5):1584-91
18058964
Infect Immun. 2007 Nov;75(11):5175-84
17724066
Chem Rev. 2014 Jun 11;114(11):5728-52
24745365
Analyst. 2002 Jun;127(6):803-8
12146915
Angew Chem Int Ed Engl. 2001 Oct 1;40(19):3685-3688
11592222
Anal Chem. 2015 Jan 20;87(2):1358-65
25530496
J Org Chem. 1999 May 14;64(10):3745-3746
11674509
Anal Chem. 2003 Aug 1;75(15):3941-5
14572067
Talanta. 2007 Dec 15;74(3):308-17
18371644
Eur J Clin Microbiol Infect Dis. 2010 Feb;29(2):187-90
19941020
Biosens Bioelectron. 2009 May 15;24(9):2766-71
19278848
Am J Crit Care. 1995 Nov;4(6):429-34
8556083
Angew Chem Int Ed Engl. 2014 Nov 10;53(46):12503-7
25113247
Biosens Bioelectron. 2007 Apr 15;22(9-10):1961-7
17010599
Talanta. 2015 Aug 15;141:300-6
25966418
Analyst. 2009 Jan;134(1):52-9
19082174
Anal Chem. 2010 Jan 15;82(2):723-8
19954210
Biosens Bioelectron. 1998 Jan 1;13(1):113-31
9519454
Chem Rev. 2008 Feb;108(2):462-93
18229953
Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14017-22
15365183
Lab Chip. 2013 Nov 21;13(22):4352-7
24056409
Anal Chem. 2003 May 1;75(9):2181-7
12720360
PLoS One. 2012;7(9):e45611
23029134
Biosens Bioelectron. 2010 Dec 15;26(4):1313-9
20688505
Biosens Bioelectron. 2012 Feb 15;32(1):89-95
22209071
Lab Chip. 2008 Dec;8(12):2091-104
19023472
ACS Nano. 2013 Jun 25;7(6):4733-45
23688050
Clin Vaccine Immunol. 2009 Mar;16(3):408-13
19129473
Science. 1990 Aug 3;249(4968):505-10
2200121
Biosens Bioelectron. 2011 Jan 15;26(5):2018-24
20875950
J Clin Microbiol. 2010 Jan;48(1):22-5
20007399
Curr Opin Microbiol. 2005 Oct;8(5):504-9
16098787
Biotechnol Adv. 2015 Jan-Feb;33(1):178-190
25450190
Nat Biotechnol. 2004 Jul;22(7):883-7
15170215
Clin Chem. 2001 Oct;47(10):1885-93
11568115
Biosens Bioelectron. 2013 Apr 15;42:460-6
23238319
J Clin Virol. 2011 May;51(1):59-63
21367654
Biosens Bioelectron. 2015 May 15;67:419-23
25223553
Talanta. 2007 Dec 15;74(3):291-307
18371643
Biosens Bioelectron. 2011 Jan 15;26(5):2208-14
20956078
Bacteriol Rev. 1971 Sep;35(3):235-41
4329869
Biosens Bioelectron. 2005 Feb 15;20(8):1461-70
15626599
Biosens Bioelectron. 2015 Oct 15;72:237-46
25985199
Biomed Microdevices. 2006 Dec;8(4):299-308
17003962
Anal Bioanal Chem. 2009 Jan;393(2):569-82
18696055
Small. 2009 Apr;5(7):839-45
19219836
Science. 2002 Aug 30;297(5586):1536-40
12202825
Anal Chim Acta. 2015 Jan 1;853:696-701
25467520
Sensors (Basel). 2009;9(4):3122-48
22574066
Nat Commun. 2012;3:1283
23250413
J Am Chem Soc. 2013 Aug 14;135(32):11832-9
23841845
J Am Chem Soc. 2003 Aug 27;125(34):10192-3
12926940
Biosens Bioelectron. 2009 Mar 15;24(7):1899-904
19010660
Anal Chem. 2002 Mar 15;74(6):1442-8
11922316
World Health Organ Tech Rep Ser. 2013;(976):i-xiii, 1-125
23687800
J Immunol Methods. 1996 Sep 9;195(1-2):15-25
8814315
J Clin Microbiol. 2005 Oct;43(10):5397-9
16208030
Nature. 1990 Aug 30;346(6287):818-22
1697402
Chem Rev. 2004 Jan;104(1):293-346
14719978
Nature. 2006 Nov 23;444 Suppl 1:73-9
17159896
Anal Biochem. 1984 Mar;137(2):335-43
6375455
Emerg Infect Dis. 2004 Feb;10(2):294-9
15030700
Lab Chip. 2011 Aug 21;11(16):2686-92
21734986
J Am Chem Soc. 2004 May 19;126(19):5932-3
15137735
Anal Chem. 2009 Feb 15;81(4):1660-8
19159221
Lancet. 2012 Dec 1;380(9857):1956-65
23200504
Acc Chem Res. 2008 Dec;41(12):1578-86
18447366
Biosens Bioelectron. 2008 Jun 15;23(11):1588-94
18316186
Health Technol Assess. 2007 Jan;11(3):1-196
17266837
EMBO Rep. 2008 Jul;9 Suppl 1:S13-7
18578017
Biosens Bioelectron. 2004 Jan 15;19(6):515-30
14683635
Langmuir. 2005 Oct 11;21(21):9625-9
16207045
Mol Cell Biochem. 1990 Mar 27;93(2):195-206
2345544
Anal Chem. 2014 Jul 15;86(14):7057-62
24937125
Bioconjug Chem. 2002 May-Jun;13(3):554-60
12009946
Chem Soc Rev. 2012 Mar 21;41(6):2283-307
22143223
Pediatr Res. 2010 May;67(5):458-68
20075759
Anal Bioanal Chem. 2008 May;391(2):479-85
18273606
PLoS Med. 2006 Oct;3(10):e417
17032062
Proc Natl Acad Sci U S A. 2004 Oct 19;101(42):15027-32
15477593
Anal Chem. 2007 Jul 15;79(14):5232-40
17579481
Nat Protoc. 2006;1(4):1711-24
17487154
J Am Chem Soc. 2006 Feb 22;128(7):2228-9
16478173
PLoS One. 2012;7(5):e36966
22693561
Chem Soc Rev. 2015 Oct 7;44(17):5941-58
26505053
Biomaterials. 2006 Mar;27(9):1679-87
16318871
Science. 2008 Jul 18;321(5887):365-7
18635792
Nature. 1947 Jul 12;159(4054):41-3
20252563
Eur Respir J. 2011 Jan;37(1):88-99
21030451
Bioelectrochemistry. 2005 Oct;67(2):143-50
16046192
Anal Chem. 2004 Dec 1;76(23):7126-30
15571369
Adv Drug Deliv Rev. 2010 Mar 18;62(4-5):408-23
19914316
Small. 2013 Aug 12;9(15):2553-63, 2478
23447456
Lab Chip. 2015 Feb 21;15(4):1009-22
25474561
Clin Infect Dis. 2007 Dec 15;45 Suppl 4:S221-5
18190290
Science. 2002 Feb 22;295(5559):1503-6
11859188
Sensors (Basel). 2009;9(7):5534-57
22346713
Inorg Chem. 2012 Mar 19;51(6):3490-7
22390791
Science. 2007 Jun 15;316(5831):1579-80
17569853
Nucleic Acids Res. 2007;35(10):e74
17478499
Clin Infect Dis. 2007 Jan 1;44(1):128-34
17143828
J Virol Methods. 2014 Mar;197:29-33
24269797
Angew Chem Int Ed Engl. 2004 Dec 3;43(47):6469-71
15578785
N Engl J Med. 2011 Jan 20;364(3):236-47
21247314
Anal Chim Acta. 2011 Mar 25;690(1):10-25
21414432
Bioconjug Chem. 1999 Mar-Apr;10(2):186-91
10077466
Clin Chem. 2007 Jul;53(7):1323-9
17510304
PLoS One. 2011 May 09;6(5):e19738
21573065
J Control Release. 2012 Apr 30;159(2):164-80
22192572
J Am Chem Soc. 2003 Dec 24;125(51):15702-3
14677934
J Clin Microbiol. 2005 Aug;43(8):4015-21
16081944
J Clin Microbiol. 1999 May;37(5):1489-97
10203511
Anal Chem. 2015 Feb 17;87(4):2290-8
25597471
Chemistry. 2014 Nov 17;20(47):15555-60
25263248
Clin Chim Acta. 2010 Dec 14;411(23-24):1969-75
20713034
Nano Lett. 2007 Feb;7(2):380-3
17298004
Talanta. 2002 Apr 1;56(5):837-46
18968562
Clin Lab Med. 2001 Jun;21(2):241-53, vii
11396081
Clin Infect Dis. 2009 Oct 1;49(7):1090-3
19725784
Analyst. 2011 Jan 7;136(1):134-9
20927441
Lab Chip. 2007 Jul;7(7):868-75
17594006
Anal Chem. 2001 Sep 15;73(18):4450-6
11575792
Diam Relat Mater. 2014 Feb 1;42:49-57
24910503
Anal Chem. 2015 Oct 20;87(20):10292-8
26382664
Fresenius J Anal Chem. 2000 Mar-Apr;366(6-7):622-34
11225774