Lifting the Differentiation Embargo.
Effective differentiation therapy for acute myeloid leukemia (AML) has been restricted to a small subset of patients with one defined genetic abnormality. Using an unbiased small molecule screen, Sykes et al. now identify a mechanism of de-repression of differentiation in several models of AML driven by distinct genetic drivers.
Department of Haematology, Glasgow Royal Infirmary, 84 Castle Street, Glasgow G4 OSF, UK. Electronic address: annelouiselatif@nhs.net.
Anne-Louise
AL
Latif
Paul O'Gorman Leukaemia Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow G12 OZD, UK. Electronic address: tessa.holyoake@glasgow.ac.uk.
Tessa L
TL
Holyoake
D002454:Cell Differentiation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D017770:Lifting