In vitro fertilization outcomes after ablation of endometriomas using plasma energy: A retrospective case-control study.
OBJECTIVE
Ovarian endometrioma ablation using plasma energy appears to be a valuable alternative to cystectomy, because it could spare underlying ovarian parenchyma resulting in high spontaneous and overall pregnancy rates. After initial postoperative decrease, anti-mullerian hormone (AMH) level progressively increases several months after ablation. The aim of our study was to assess the outcomes of in vitro fertilization (IVF) in women managed for ovarian endometriomas by ablation using plasma energy, when compared to those in women free of endometriosis.


METHODS
Retrospective preliminary case-control study, enrolling women undergoing IVF or IntraCytoplasmic Sperm Injection (ICSI), from July 2009 to December 2014. Cases were infertile women with previous ovarian endometrioma ablation using plasma energy and were matched by age, AMH level and assisted reproductive technique with controls presumed free of endometriosis. IVF/ICSI response (type of protocol, dose of gonadotrophin, number of oocytes, fertilization rate) and outcomes were compared between the two groups.


RESULTS
In all, 37 cases were compared to 74 controls. Age (30.9±4.4 years vs. 31.7±4.2 years), AMH level (2.8±2ng/mL vs. 2.8±1.7ng/mL) and ART procedures (ICSI in 24.3% vs. 27%) were comparable between the two groups. Of the 37 cases, previous surgical procedures on right and left ovaries were performed in 27% and 21.6% of patients respectively, 81% of patients were nullipara. AFSr score was 73±41, while deep endometriosis infiltrated the rectum and the sigmoid colon in respectively 40.5% and 27% of patients. Despite a lower number of oocytes retrieved, cases presented better implantation rate, pregnancy and delivery rates per cycle, oocyte retrieval, transfer, and embryo, as well as superior cumulative birth rate per transfer.


CONCLUSIONS
Ovarian endometrioma ablation using plasma energy is followed by good IVF/ICSI outcomes, suggesting that surgical procedure spares underlying ovarian parenchyma. These results consolidate those of previous studies reporting high spontaneous conception rate. Hence, ovarian endometrioma ablation using plasma energy appears to be a valuable alternative to cystectomy in patients presenting with endometriosis and pregnancy intention.
Department of gynecology and obstetrics, Rouen university hospital, 76031 Rouen, France; Expert Center in the Diagnostic and Multidisciplinar Management of Endometriosis "Rouendometriose", 76031 Rouen, France.
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Motte
Department of gynecology and obstetrics, Rouen university hospital, 76031 Rouen, France; Expert Center in the Diagnostic and Multidisciplinar Management of Endometriosis "Rouendometriose", 76031 Rouen, France; Research Group 4308 "Spermatogenesis and Gamete Quality", IHU Rouen Normandy, IFRMP23, reproductive biology laboratory, Rouen university hospital, 76031 Rouen, France. Electronic address: horace.roman@gmail.com.
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Roman
Department of gynecology and obstetrics, Rouen university hospital, 76031 Rouen, France; Expert Center in the Diagnostic and Multidisciplinar Management of Endometriosis "Rouendometriose", 76031 Rouen, France.
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Clavier
Department of reproductive biology, Rouen university hospital, 76031 Rouen, France.
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Jumeau
Department of gynecology and obstetrics, Rouen university hospital, 76031 Rouen, France; Expert Center in the Diagnostic and Multidisciplinar Management of Endometriosis "Rouendometriose", 76031 Rouen, France.
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Chanavaz-Lacheray
Department of gynecology and obstetrics, Rouen university hospital, 76031 Rouen, France; Expert Center in the Diagnostic and Multidisciplinar Management of Endometriosis "Rouendometriose", 76031 Rouen, France.
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Letailleur
Department of gynecology and obstetrics, Rouen university hospital, 76031 Rouen, France; Expert Center in the Diagnostic and Multidisciplinar Management of Endometriosis "Rouendometriose", 76031 Rouen, France.
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Darwish
Expert Center in the Diagnostic and Multidisciplinar Management of Endometriosis "Rouendometriose", 76031 Rouen, France; Research Group 4308 "Spermatogenesis and Gamete Quality", IHU Rouen Normandy, IFRMP23, reproductive biology laboratory, Rouen university hospital, 76031 Rouen, France; Department of reproductive biology, Rouen university hospital, 76031 Rouen, France.
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Rives
D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood; D016022:Case-Control Studies; D015653:Cystectomy; D055356:Endometrial Ablation Techniques / Q000379:methods* / Q000706:statistics & numerical data; D004715:Endometriosis / Q000601:surgery*; D005260:Female; D005298:Fertility; D005307:Fertilization in Vitro; D005602:France; D006801:Humans; D007247:Infertility, Female / Q000628:therapy; D054315:Oocyte Retrieval; D010049:Ovarian Diseases / Q000601:surgery*; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D016896:Treatment Outcome
D054304:Anti-Mullerian Hormone
AMH; Antimullerian hormone; Endométriomes; Fertility; Fertilité; ICSI; IVF; Ovarian endometriomas; Plasma energy; Énergie plasma