Occupational exposure to metals and risk of meningioma: a multinational case-control study.
The aim of the study was to examine associations between occupational exposure to metals and meningioma risk in the international INTEROCC study. INTEROCC is a seven-country population-based case-control study including 1906 adult meningioma cases and 5565 population controls. Incident cases were recruited between 2000 and 2004. A detailed occupational history was completed and job titles were coded into standard international occupational classifications. Estimates of mean workday exposure to individual metals and to welding fumes were assigned based on a job-exposure-matrix. Adjusted odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated using conditional logistic regression. Although more controls than cases were ever exposed to metals (14 vs. 11 %, respectively), cases had higher median cumulative exposure levels. The ORs for ever vs. never exposure to any metal and to individual metals were mostly greater than 1.0, with the strongest association for exposure to iron (OR 1.26, 95 % CI 1.0-1.58). In women, an increased OR of 1.70 (95 % CI 1.0-2.89) was seen for ever vs never exposure to iron (OR in men 1.19, 95 % CI 0.91-1.54), with positive trends in relation with both cumulative and duration of exposure. These results remained after consideration of other occupational metal or chemical co-exposures. In conclusion, an apparent positive association between occupational exposure to iron and meningioma risk was observed, particularly among women. Considering the fact that meningioma is a hormone dependent tumor, the hypothesis that an interaction between iron and estrogen metabolism may be a potential mechanism for a carcinogenic effect of iron should be further investigated.
The Cancer and Radiation Epidemiology Unit, The Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer, 5262000, Ramat Gan, Israel. siegals@gertner.health.gov.il.|Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. siegals@gertner.health.gov.il.
Siegal
S
Sadetzki
The Cancer and Radiation Epidemiology Unit, The Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer, 5262000, Ramat Gan, Israel.
Angela
A
Chetrit
ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.|Universitat Pompeu Fabra (UPF), Barcelona, Spain.|CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.|McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada.
Michelle C
MC
Turner
Institute of Occupational Medicine, Edinburgh, UK.
Martie
M
van Tongeren
Monash University, Melbourne, Australia.
Geza
G
Benke
ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.|Universitat Pompeu Fabra (UPF), Barcelona, Spain.|CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Jordi
J
Figuerola
School of Medicine, University of Leeds, Leeds, UK.
Sarah
S
Fleming
Unité Mixte de Recherche Epidémiologique Transport Travail Environnement Université Lyon 1/IFSTTAR, Université de Lyon, Lyon, France.
Martine
M
Hours
Oregon State University, Corvallis, OR, USA.
Laurel
L
Kincl
McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada.|Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada.
Daniel
D
Krewski
Massey University, Wellington, New Zealand.
Dave
D
McLean
INRS-Institut Armand-Frappier, Institut national de la recherche scientifique, Université du Québec, Laval, Québec, Canada.
Marie-Elise
ME
Parent
University of Montreal Hospital Research Centre, Montreal, Québec, Canada.
Lesley
L
Richardson
Unit of Environmental Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Brigitte
B
Schlehofer
Unit of Environmental Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Klaus
K
Schlaefer
Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center, Johannes-Gutenberg University Mainz, Mainz, Germany.
Maria
M
Blettner
International Agency for Research on Cancer (IARC), Section of Environment and Radiation, Lyon, France.
Joachim
J
Schüz
University of Montreal Hospital Research Centre, Montreal, Québec, Canada.
Jack
J
Siemiatycki
ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.|Universitat Pompeu Fabra (UPF), Barcelona, Spain.|CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Elisabeth
E
Cardis
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007391:International Cooperation; D016015:Logistic Models; D008297:Male; D008577:Meningeal Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D008579:Meningioma / Q000453:epidemiology* / Q000209:etiology*; D008670:Metals / Q000633:toxicity*; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D012189:Retrospective Studies; D055815:Young Adult
D008670:Metals
Brain tumors; Meningioma; Metals; Occupational exposure; Risk factors
Environ Health Perspect. 2005 Sep;113(9):1209-11
16140629
Cancer. 2008 Oct 1;113(7 Suppl):1953-68
18798534
Antioxid Redox Signal. 2009 Dec;11(12):2939-43
19527179
Nutrients. 2013 Jul 24;5(8):2836-59
23887041
Neuro Oncol. 2011 Mar;13(3):345-52
21339193
Neuro Oncol. 2012 Nov;14(11):1316-24
22952197
Occup Environ Med. 2011 Sep;68(9):631-40
21659469
Am J Ind Med. 2004 May;45(5):395-407
15095422
J Natl Cancer Inst. 2008 Jul 16;100(14):996-1002
18612130
Occup Environ Med. 2009 Jul;66(7):448-55
19153109
Occup Environ Med. 2012 Jul;69(7):465-71
22467796
Environ Health Perspect. 2000 Aug;108(8):793-5
10964802
Toxicology. 2011 May 10;283(2-3):65-87
21414382
West J Med. 1982 Dec;137(6):531-9
7164433
Proc R Soc Med. 1965 May;58:295-300
14283879
Cancer Epidemiol. 2010 Feb;34(1):55-61
20061201
Cancer Causes Control. 2011 May;22(5):697-714
21359526
Scand J Work Environ Health. 2008 Dec;34(6):444-50
19137206
Breast Cancer Res Treat. 2005 Jul;92(2):107-14
15986119
Mutat Res. 2012 May 1;733(1-2):78-82
22192535
Br J Cancer. 2012 Jun 19;107 Suppl 1:S56-70
22710680
Eur J Epidemiol. 2007;22(9):647-64
17636416
Mutat Res. 2003 Dec 10;533(1-2):153-71
14643418
Sci Total Environ. 2012 Jul 15;430:68-74
22634551
Eur J Cancer. 2002 Mar;38(5):696-704
11916553
Ann Occup Hyg. 2013 Jun;57(5):610-26
23467593
IARC Monogr Eval Carcinog Risks Hum. 2012;100(Pt C):11-465
23189751
Int J Environ Health Res. 2014 Aug;24(4):378-99
24117228
Cancer Epidemiol Biomarkers Prev. 2014 Sep;23 (9):1863-72
24935666
Am Heart J. 2000 Jul;140(1):98-104
10874269
Br J Cancer. 2012 Jun 19;107 Suppl 1:S76-84
22710682
Cancer Epidemiol Biomarkers Prev. 2014 Jan;23(1):12-31
24243555
Neuro Oncol. 2013 Nov;15 Suppl 2:ii1-56
24137015
Cancer Sci. 2009 Jan;100(1):9-16
19018762
Occup Environ Med. 2014 Apr;71(4):253-8
24474387
Radiat Res. 2005 Apr;163(4):424-32
15799699
Diabetes Metab. 2000 Feb;26(1):22-7
10705100
J Occup Med Toxicol. 2013 May 22;8(1):14
23697536
J Neurooncol. 2010 Sep;99(3):307-14
20821343