Chiral Phosphoric Acid Catalyzed Asymmetric Oxidative Dearomatization of Naphthols with Quinones.
A highly enantioselective oxidative dearomatization of naphthols with quinones catalyzed by a chiral spirocyclic phosphoric acid is described. The strategy provides concise access to enantioenriched cyclohexadienones with a quinone moiety. Remarkably, the obtained products could be easily transformed to a potentially useful dihydronaphtho[2,1-b]benzofuran scaffold.
School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou 510006, China.|Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University , Lanzhou 730000, China.
Gongming
G
Zhu
Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University , Lanzhou 730000, China.
Guangjun
G
Bao
Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University , Lanzhou 730000, China.
Yiping
Y
Li
Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University , Lanzhou 730000, China.
Junxian
J
Yang
Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University , Lanzhou 730000, China.
Wangsheng
W
Sun
School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou 510006, China.|Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University , Lanzhou 730000, China.
Jing
J
Li
School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou 510006, China.
Liang
L
Hong
School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou 510006, China.|Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University , Lanzhou 730000, China.
Rui
R
Wang