Particular aspects in the cytogenetics and molecular biology of salivary gland tumours - current review of reports.
Salivary gland tumours are a group of lesions whose heterogeneity of biological and pathological features is widely reflected in the molecular aspect. This is demonstrated by an increasing number of studies in the field of genetics of these tumours. The aim of this study was to collect the most significant scientific reports on the cytogenetic and molecular data concerning these tumours, which might facilitate the identification of potential biomarkers and therapeutic targets. The analysis covered 71 papers included in the PubMed database. We focused on the most common tumours, such as pleomorphic adenoma, Warthin tumour, mucoepidermoid carcinoma, and others. The aim of this study is to present current knowledge about widely explored genotypic alterations (such as PLAG1 gene in pleomorphic adenoma or MECT1 gene in mucoepidermoid carcinoma), and also about rare markers, like Mena or SOX10 protein, which might also be associated with tumourigenesis and carcinogenesis of these tumours.
Department and Chair of Otolaryngology, Medical University of Warsaw, Warsaw, Poland.
Aleksandra J
AJ
Ochal-Choińska
Department and Chair of Otolaryngology, Medical University of Warsaw, Warsaw, Poland.
Ewa
E
Osuch-Wójcikiewicz
carcinoma ex pleomorphic adenoma; genes; molecular; pleomorphic adenoma; salivary gland tumours
J Oral Pathol Med. 1997 May;26(5):217-23
9178173
Arch Pathol Lab Med. 2000 Jun;124(6):836-9
10835516
Am J Pathol. 2002 Oct;161(4):1315-23
12368205
Cell Death Dis. 2014 May 22;5:e1246
24853424
Cancer Res. 1999 Feb 15;59(4):918-23
10029085
Histopathology. 2003 Apr;42(4):348-56
12653946
Clin Cancer Res. 2005 Oct 15;11(20):7334-43
16243805
Cancer Genet Cytogenet. 1998 Dec;107(2):132-6
9844608
Clin Otolaryngol Allied Sci. 2001 Apr;26(2):134-42
11309055
Cancer Genet Cytogenet. 1993 Jan;65(1):27-31
8381711
Anticancer Res. 1988 Jul-Aug;8(4):637-43
3178153
Int J Oral Sci. 2015 Mar 23;7(1):18-22
25012870
Acta Otorhinolaryngol Ital. 2005 Jun;25(3):153-60
16450770
Eur J Histochem. 2012 Feb 07;56(1):e8
22472896
Int J Oral Maxillofac Surg. 2004 Sep;33(6):593-7
15308260
Cancer Genet Cytogenet. 1994 Sep;76(2):129-35
7923062
Virchows Arch. 2002 Nov;441(5):428-36
12447671
Cancer Genet Cytogenet. 1996 Mar;87(1):29-33
8646736
Int J Cancer. 2009 Jun 15;124(12):2855-63
19347935
Genes Chromosomes Cancer. 2000 Feb;27(2):162-8
10612804
Otolaryngol Pol. 2010 Sep-Oct;64(5):281-7
21166137
Oncogene. 1998 Feb 19;16(7):865-72
9484777
Curr Oncol Rep. 2012 Apr;14(2):166-74
22246609
J Mol Diagn. 2004 Aug;6(3):205-10
15269296
Hum Pathol. 2000 Nov;31(11):1377-80
11112212
Cancer Genet Cytogenet. 2004 Jul 15;152(2):124-8
15262430
Contemp Oncol (Pozn). 2013;17(1):103-6
23788973
Otolaryngol Pol. 2010 Sep-Oct;64(5):288-95
21166138
Histopathology. 2005 Feb;46(2):144-52
15693886
Genes Chromosomes Cancer. 1994 Jun;10(2):115-21
7520264
Cancer Res. 1996 Mar 1;56(5):1151-4
8640776
Oncogene. 1998 Jan 8;16(1):83-8
9467946
ORL J Otorhinolaryngol Relat Spec. 2003 Jan-Feb;65(1):26-32
12624503
Head Neck. 2013 Oct;35(10):1431-8
22987447
Pol J Pathol. 2012 Dec;63(4):286-91
23359201
J Surg Oncol. 1995 Dec;60(4):232-7
8551731
Mod Pathol. 2005 Aug;18(8):1048-55
15920557
Anticancer Res. 1989 Nov-Dec;9(6):1565-6
2627110
Exp Gerontol. 2013 Apr;48(4):444-50
23416193
Pol J Pathol. 2013 Jun;64(2):144-8
23900873
Int J Oral Maxillofac Surg. 2001 Dec;30(6):538-44
11829237
Biomed Res Int. 2013;2013:365192
23956979
Int J Oral Maxillofac Surg. 1993 Dec;22(6):359-61
8106812
Genes Chromosomes Cancer. 2001 Feb;30(2):161-7
11135432
Diagn Mol Pathol. 1998 Aug;7(4):224-31
9917133
Pathol Res Pract. 2014 Nov;210(11):726-32
25086675
Oncogene. 1998 Mar;16(11):1409-16
9525740
Exp Cell Res. 2004 Jan 1;292(1):21-8
14720503
Hum Pathol. 1997 Aug;28(8):881-6
9269822
Cancer Res. 1997 Jan 1;57(1):13-7
8988031
Am J Pathol. 2002 Oct;161(4):1127-33
12368186
Clin Cancer Res. 2011 Jul 1;17(13):4320-30
21551254
Pathol Int. 2013 Oct;63(10):496-501
24147430
J Clin Oncol. 2007 Sep 1;25(25):3978-84
17761983
Hum Pathol. 2001 Mar;32(3):352
11274649
J Clin Pathol. 1997 Aug;50(8):661-3
9301549
Hum Pathol. 1996 Nov;27(11):1204-10
8912832
Cancer Genet Cytogenet. 1997 May;95(1):9-15
9140448
Int J Surg Pathol. 2005 Oct;13(4):337-42
16273189
Cancer. 2010 Dec 15;116(24):5749-56
20824717
Virchows Arch. 2002 Jan;440(1):77-84
11942580
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003 May;95(5):586-93
12738950
Pathol Oncol Res. 2011 Sep;17(3):765-9
21553343
Cancer Genet Cytogenet. 1998 Sep;105(2):160-3
9723034
J Pathol. 2000 Jul;191(3):274-81
10878549
Mod Pathol. 2013 Aug;26(8):1041-50
23558573
Anticancer Res. 2014 Feb;34(2):671-7
24510998
Clin Cancer Res. 2008 Aug 15;14(16):5181-7
18698036
Oral Oncol. 2009 Jun;45(6):526-30
18805729
Laryngoscope. 2001 Aug;111(8):1373-8
11568571
Cancer Genet Cytogenet. 1995 Apr;80(2):165-6
7736438