Thermal Ablation of Colorectal Lung Metastases: Retrospective Comparison Among Laser-Induced Thermotherapy, Radiofrequency Ablation, and Microwave Ablation.
OBJECTIVE
The purpose of this study is to retrospectively evaluate local tumor control, time to tumor progression, and survival rates among patients with lung metastatic colorectal cancer who have undergone ablation therapy performed using laser-induced thermotherapy (LITT), radiofrequency ablation (RFA), or microwave ablation (MWA).


METHODS
Data for this retrospective study were collected from 231 CT-guided ablation sessions performed for 109 patients (71 men and 38 women; mean [± SD] age, 68.6 ± 11.2 years; range, 34-94 years) from May 2000 to May 2014. Twenty-one patients underwent LITT (31 ablations), 41 patients underwent RFA (75 ablations), and 47 patients underwent MWA (125 ablations). CT scans were acquired 24 hours after each therapy session and at follow-up visits occurring at 3, 6, 12, 18, and 24 months after ablation. Survival rates were calculated from the time of the first ablation session, with the use of Kaplan-Meier and log-rank tests. Changes in the volume of the ablated lesions were measured using the Kruskal-Wallis method.


RESULTS
Local tumor control was achieved in 17 of 25 lesions (68.0%) treated with LITT, 45 of 65 lesions (69.2%) treated with RFA, and 91 of 103 lesions (88.3%) treated with MWA. Statistically significant differences were noted when MWA was compared with LITT at 18 months after ablation (p = 0.01) and when MWA was compared with RFA at 6 months (p = 0.004) and 18 months (p = 0.01) after ablation. The overall median time to local tumor progression was 7.6 months. The median time to local tumor progression was 10.4 months for lesions treated with LITT, 7.2 months for lesions treated with RFA, and 7.5 months for lesions treated with MWA, with no statistically significant difference noted. New pulmonary metastases developed in 47.6% of patients treated with LITT, in 51.2% of patients treated with RFA, and in 53.2% of patients treated with MWA. According to the Kaplan-Meier test, median survival was 22.1 months for patients who underwent LITT, 24.2 months for those receiving RFA, and 32.8 months for those who underwent MWA. The overall survival rate at 1, 2, and 4 years was 95.2%, 47.6%, and 23.8%, respectively, for patients treated with LITT; 76.9%, 50.8%, and 8.0%, respectively, for patients treated with RFA; and 82.7%, 67.5%, and 16.6%, respectively, for patients treated with MWA. The log-rank test revealed no statistically significant difference among LITT, RFA, and MWA. The progression-free survival rate at 1, 2, 3, and 4 years was 96.8%, 52.7%, 24.0%, and 19.1%, respectively, for patients who underwent LITT; 77.3%, 50.2%, 30.8%, and 16.4%, respectively, for patients who underwent RFA; and 54.6%, 29.1%, 10.0%, and 1.0%, respectively, for patients who underwent MWA, with no statistically significant difference noted among the three ablation methods.


CONCLUSIONS
LITT, RFA, and MWA can be used as therapeutic options for lung metastases resulting from colorectal cancer. Statistically significant differences in local tumor control revealed a potential advantage in using MWA. No differences in time to tumor progression or survival rates were detected when the three different ablation methods were compared.
1 Institute for Diagnostic and Interventional Radiology, Johann Wolfgang Goethe-University Hospital, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.
Thomas J
TJ
Vogl
1 Institute for Diagnostic and Interventional Radiology, Johann Wolfgang Goethe-University Hospital, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.
Romina
R
Eckert
1 Institute for Diagnostic and Interventional Radiology, Johann Wolfgang Goethe-University Hospital, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.|2 Department of Diagnostic and Interventional Radiology, Alexandria University Hospital, Alexandria, Egypt.
Nagy N N
NN
Naguib
1 Institute for Diagnostic and Interventional Radiology, Johann Wolfgang Goethe-University Hospital, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.
Martin
M
Beeres
1 Institute for Diagnostic and Interventional Radiology, Johann Wolfgang Goethe-University Hospital, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.
Tatjana
T
Gruber-Rouh
1 Institute for Diagnostic and Interventional Radiology, Johann Wolfgang Goethe-University Hospital, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.|3 Department of Diagnostic and Interventional Radiology, Cairo University Hospital, Cairo, Egypt.
Nour-Eldin A
NA
Nour-Eldin
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017115:Catheter Ablation / Q000401:mortality*; D015179:Colorectal Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D006979:Hyperthermia, Induced / Q000401:mortality; D053685:Laser Therapy / Q000401:mortality*; D008175:Lung Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008872:Microwaves / Q000627:therapeutic use*; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome
ablation; colorectal carcinoma; laser-induced thermotherapy; lung metastases; microwave; radiofrequency