Role of Spirulina in mitigating hemato-toxicity in Swiss albino mice exposed to aluminum and aluminum fluoride.
Aluminum is ingested through foods, water, air, and even drugs. Its intake is potentiated further through foods and tea prepared in aluminum utensils and Al salt added in the drinking water for removal of suspended impurities and also fluoride in the affected areas. The ameliorating role of a blue green alga Spirulina is well documented to various pollutants in the animal models. We, therefore, examined its protective role (230 mg/kg body weight) on the hematology of male Swiss albino mice treated with aluminum (sub-acute = 78.4 mg/kg body weight for 7 days, sub-chronic = 7.8 mg/kg body weight for 90 days) and aluminum fluoride (sub-acute = 103 mg/kg body weight, sub-chronic = 21 mg/kg body weight), along with their recovery after 90 days of sub-chronic exposure. This study revealed significant reduction in the values of RBC (5-18 %), Hb (15-17 %), PCV (8-14 %), and platelets (26-36 %), and increase in WBC (54-124 %) in the treated mice, particularly after sub-acute exposure. Aluminum fluoride was comparatively more toxic than aluminum. Further, Spirulina supplement not only alleviated toxicity of test chemicals in Swiss albino mice but also led to their better recovery after withdrawal.
Department of Zoology, University of Rajasthan, Jaipur, 302004, India. shwetdr@gmail.com.
Shweta
S
Sharma
Department of Botany, University of Rajasthan, Jaipur, 302004, India.
K P
KP
Sharma
Department of Zoology, University of Rajasthan, Jaipur, 302004, India.
Subhasini
S
Sharma
D000535:Aluminum / Q000633:toxicity*; D017607:Aluminum Compounds / Q000633:toxicity*; D000818:Animals; D001769:Blood / Q000187:drug effects*; D064419:Chemically-Induced Disorders / Q000517:prevention & control*; D019587:Dietary Supplements; D005459:Fluorides / Q000633:toxicity*; D008297:Male; D051379:Mice; D010710:Phosphates; D011897:Random Allocation; D053545:Spirulina; D059551:Toxicity Tests, Subacute; D059550:Toxicity Tests, Subchronic
D017607:Aluminum Compounds; D010710:Phosphates; C012980:fluorophosphate; D000535:Aluminum; D005459:Fluorides; C032311:aluminum fluoride
Aluminum; Aluminum fluoride; Blood cells; Spirulina; Swiss albino mice
Br J Ind Med. 1966 Oct;23(4):305-12
5926895
Biol Trace Elem Res. 2016 May;171(1):116-23
26354416
Toxicol Ind Health. 2002 Aug;18(7):309-20
15068131
Indian J Exp Biol. 2016 Jan;54(1):44-55
26891552
Indian Pediatr. 2009 Sep;46(9):755-9
19812419
Int Immunopharmacol. 2002 Mar;2(4):423-34
11962722
Pharmacol Toxicol. 2000 Mar;86(3):135-9
10752672
J Trace Elem Med Biol. 2004;18(1):113-21
15487771
J Cell Biochem. 2012 May;113(5):1581-9
22174104
J Inorg Biochem. 2001 Nov;87(1-2):21-7
11709209
J Am Soc Nephrol. 1993 Apr;3(10):1672-9
8318683
Cell J. 2015 Spring;17(1):137-44
25870843
Wei Sheng Yan Jiu. 2007 Jan;36(1):34-6
17424844
Rocz Panstw Zakl Hig. 1993;44(1):99
8235353
Arch Toxicol. 2007 Jan;81(1):11-7
16721596
Biomed Pharmacother. 2016 Feb;77:79-85
26796269
Free Radic Biol Med. 2004 Feb 1;36(3):380-7
15036357
PLoS One. 2013;8(3):e59177
23555627
J Trace Elem Med Biol. 2013 Apr;27(2):160-7
23199702
Environ Sci Pollut Res Int. 2015 Feb;22(4):3023-31
25231739
Biochim Biophys Acta. 2005 Aug 15;1745(1):124-30
16085060
Biochim Biophys Acta. 2002 Feb 1;1558(2):142-50
11779564
J Appl Toxicol. 2006 Sep-Oct;26(5):444-51
16858688
Immunopharmacol Immunotoxicol. 2015 Apr;37(2):126-39
25567297
Food Chem Toxicol. 2004 Jun;42(6):925-33
15110101
Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2258-63
11854521
Yonsei Med J. 2004 Feb 29;45(1):135-9
15004880
J Inorg Biochem. 2005 Mar;99(3):822-7
15708804
Cancer Chemother Pharmacol. 2006 Dec;58(6):802-8
16552571
PLoS One. 2015 Jun 01;10(6):e0126780
26029926