Treatment of ibuprofen toxicity with serial charcoal hemoperfusion and hemodialysis in a dog.
OBJECTIVE
To describe the efficacy of serial charcoal hemoperfusion and hemodialysis in removing ibuprofen from a dog with severe clinical signs of toxicity.


METHODS
A dog ingested a minimum of 2,200 mg/kg of ibuprofen resulting in progressive neurologic dysfunction that progressed to a comatose state by the time of presentation. Extracorporeal charcoal hemoperfusion coupled serially with hemodialysis was performed to remove ibuprofen from this patient. Serial charcoal hemoperfusion and hemodialysis therapy resulted in complete reversal of the neurologic dysfunction in this dog. No evidence of acute kidney or hepatic injury was observed. Serum ibuprofen concentrations confirmed the efficacy of this treatment.
This report details the technique for extracorporeal extraction of ibuprofen, a methodology that could be employed for other toxicities due to substances with similar pharmacokinetics. Complications and limitations (eg, saturation of the charcoal cartridge) of the therapy are discussed.
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104.
Barbara S
BS
Tauk
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104. jdfoster@friendshiphospital.com.
Jonathan D
JD
Foster
D000818:Animals; D002606:Charcoal; D003128:Coma / Q000209:etiology / Q000662:veterinary; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D006464:Hemoperfusion / Q000662:veterinary; D007052:Ibuprofen / Q000506:poisoning*; D008297:Male; D011041:Poisoning / Q000150:complications / Q000628:therapy / Q000662:veterinary; D006435:Renal Dialysis / Q000662:veterinary
D002606:Charcoal; D007052:Ibuprofen
canine; dialysis; extracorporeal therapy; toxicology