[The Role of SOCS in the Development of Tumors].
Suppressor of cytokine signaling (SOCS) family proteins are a group of negative regulatory factors that plays important roles in the negative regulation of cytokine responses by terminating the activation of the JAK-STAT and other signaling pathways. The family is composed of eight structurally related proteins. mainly through the inhibition of the activation of JAK-STAT signaling pathway and regulates cell proliferation, differentiation and apoptosis. In the process of tumor progression, the promoter CG island hypermethylation, gene mutation, gene deletion and inactivation lead to the abnormal expression of SOCS protein make JAK-STAT continuous activation, resulting in the development and metastasis of tumor. Here, we review the SOCS family members found, composition and molecular structure, the domain of the function, and the latest progress of development in tumor. Based on the important role of SOCS in tumor development, SOCS as a negative regulator factor represent a kind of tumor suppressor genes, has become a new target for tumor therapy.
Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
Chunlai
C
Liu
Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General  Hospital, Tianjin 300052, China.
Hongyu
H
Liu
Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China;Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General  Hospital, Tianjin 300052, China.
Jun
J
Chen
D000818:Animals; D019175:DNA Methylation; D006801:Humans; D005810:Multigene Family; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D015398:Signal Transduction; D050826:Suppressor of Cytokine Signaling Proteins / Q000235:genetics / Q000378:metabolism*
D050826:Suppressor of Cytokine Signaling Proteins
Leuk Res. 2011 Oct;35(10):1345-9
21592569
Genes Cells. 2007 Feb;12(2):143-54
17295835
PLoS One. 2014 Jun 25;9(6):e100826
24964072
Cell. 2002 Apr;109 Suppl:S121-31
11983158
Gene. 2016 Feb 1;576(2 Pt 2):743-52
26456195
Mol Carcinog. 2012 Feb;51(2):174-84
21520296
J Exp Med. 2004 Jun 21;199(12):1701-7
15197228
Annu Rev Immunol. 2000;18:143-64
10837055
Cancer Lett. 2014 Jan 28;342(2):238-47
22202641
Gastroenterology. 2006 Jul;131(1):179-93
16831601
Hepatology. 2008 May;47(5):1644-54
18393318
Asian Pac J Cancer Prev. 2014;15(11):4555-61
24969884
Annu Rev Immunol. 1998;16:293-322
9597132
Nature. 1997 Jun 26;387(6636):917-21
9202125
Oncol Rep. 2010 Dec;24(6):1605-12
21042758
Trends Immunol. 2009 Aug;30(8):392-400
19643666
Nat Immunol. 2003 Dec;4(12):1169-76
14639467
J Biol Chem. 2015 Feb 13;290(7):4178-91
25505247
Mol Cell Biol. 2015 Jun 1;35(11):1886-97
25776560
Cell Death Differ. 2013 Jan;20(1):139-53
22955947
EMBO J. 1999 Mar 1;18(5):1309-20
10064597
Int J Cancer. 2013 Jan 15;132(2):459-71
22532243
Curr Pharm Des. 2014;20(11):1715-25
23888939
Cancer Immunol Res. 2015 Jul;3(7):727-40
25649351
Cancer Lett. 2010 Feb 1;288(1):75-85
19646809
PLoS One. 2015 Apr 07;10(4):e0123133
25849377
APMIS. 2002 Dec;110(12):833-44
12645661
J Biol Chem. 2015 Jul 17;290(29):17894-908
26032413
Cancer Sci. 2013 Nov;104(11):1483-91
23962256
Swiss Med Wkly. 2010 Jul 15;140:w13065
20648401
Immunity. 2012 Feb 24;36(2):239-50
22342841
Mol Cell Endocrinol. 2014 Jan 25;382(1):616-621
23531638
Nat Rev Immunol. 2007 Jun;7(6):454-65
17525754
Carcinogenesis. 2013 Mar;34(3):513-21
23172663
Cytokine Growth Factor Rev. 2008 Oct-Dec;19(5-6):371-81
18948053
Blood. 2009 Nov 12;114(20):4503-6
19734449
J Exp Med. 2006 Jun 12;203(6):1391-7
16717119
Acta Neuropathol. 2011 Aug;122(2):241-51
21590492
Int J Cancer. 2012 Sep 15;131(6):1287-96
22095154
Prostate. 2011 Feb 15;71(3):318-25
20717995
Cancer Sci. 2006 Jun;97(6):439-47
16734720
Science. 1997 Sep 12;277(5332):1630-5
9287210
J Recept Signal Transduct Res. 2011 Apr;31(2):147-56
21385099
Nat Immunol. 2006 Feb;7(2):123-4
16424886
JAKSTAT. 2013 Jul 1;2(3):e24053
24069550