Ghrelin is a possible new predictor associated with executive function in patients with type 2 diabetes mellitus.
OBJECTIVE
The aim of the present research was to study the ghrelin level, executive function and their possible association in patients with type 2 diabetes mellitus.


METHODS
A total of 370 people were recruited between March 2015 and March 2016 in this study. Among them, 212 participants were patients with type 2 diabetes mellitus and 158 participants were included as the control group. Their blood sample was analyzed for the level of ghrelin and other clinical indexes. Cognitive function was measured by the Montreal Cognitive Assessment, and executive function was evaluated by the Wisconsin Card Sorting Test.


RESULTS
In the type 2 diabetes mellitus group, age, years of education, duration of diabetes, fasting blood glucose, glycated hemoglobin, hypertension and waist-to-hip ratio were correlated with total Montreal Cognitive Assessment scores. No association was found between ghrelin level and total Montreal Cognitive Assessment score in patients with type 2 diabetes mellitus. However, ghrelin was found to be a significant predictor for executive function impairment measured by the Wisconsin Card Sorting Test in patients with type 2 diabetes mellitus.


CONCLUSIONS
The level of serum ghrelin might be a biomarker of executive function and become a strong predictor of executive function impairment in patients with type 2 diabetes mellitus. Ghrelin might have a potential protective effect against cognitive function impairment in type 2 diabetes patients.
Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Siting
S
Chen
Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Xuyang
X
Zuo
Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Yuan
Y
Li
Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Tian
T
Jiang
Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Nan
N
Zhang
Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Fang
F
Dai
College of Stomatology, Anhui Medical University, Hefei, Anhui, China.
Qiaoer
Q
Chen
Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Qiu
Q
Zhang
D000328:Adult; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000523:psychology*; D056344:Executive Function; D005260:Female; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests
D015415:Biomarkers; D054439:Ghrelin
Diabetes; Executive function; Ghrelin
Clin Endocrinol (Oxf). 2009 Mar;70(3):408-14
18624998
Diabetes. 2002 Dec;51(12):3408-11
12453893
Diabetologia. 2005 Dec;48(12):2460-9
16283246
J Am Geriatr Soc. 2005 Apr;53(4):695-9
15817019
Brain Res Bull. 2010 Jan 15;81(1):33-7
19828130
Diabet Med. 1998 Jul;15(7):539-53
9686693
Diabetes Care. 2009 Jul;32(7):1261-5
19366968
Arch Clin Neuropsychol. 2006 Dec;21(8):787-96
17030111
Diabetes Care. 2004 May;27(5):1047-53
15111519
Lancet. 2005 Apr 9-15;365(9467):1333-46
15823385
Neurology. 2010 Sep 14;75(11):997-1002
20837967
Biochem Biophys Res Commun. 2002 Dec 20;299(5):739-43
12470640
Eur J Neurosci. 2011 Jan;33(2):266-75
21219473
Mol Cell Endocrinol. 2011 Jun 20;340(1):26-8
21419192
Alzheimer Dis Assoc Disord. 2011 Oct-Dec;25(4):352-63
22005105
Nature. 1999 Dec 9;402(6762):656-60
10604470
J Endocrinol Invest. 2010 Jul-Aug;33(7):496-500
20157287
Psychiatry Clin Neurosci. 2010 Dec;64(6):608-11
21029250
Eur J Pharmacol. 2004 Apr 19;490(1-3):169-75
15094083
J Diabetes Metab Disord. 2014 Feb 04;13(1):27
24495302
J Am Geriatr Soc. 2006 Mar;54(3):558-9
16551341
CNS Neurol Disord Drug Targets. 2010 Nov;9(5):557-63
20632971
J Clin Endocrinol Metab. 2002 Jun;87(6):2988
12050285
Chin J Physiol. 2006 Oct 31;49(5):244-50
17294832
Arch Neurol. 1999 Mar;56(3):303-8
10190820
J Alzheimers Dis. 2010;22(3):819-28
20858966
Diabetes. 2003 Oct;52(10):2546-53
14514639
Biomed Res Int. 2013;2013:202757
23971025
BMC Psychiatry. 2012 Sep 25;12:156
23009126
J Clin Endocrinol Metab. 2003 Dec;88(12):5747-52
14671163
Ann Med. 2007;39(2):116-36
17453675
J Exp Psychol. 1948 Aug;38(4):404-11
18874598
Nan Fang Yi Ke Da Xue Xue Bao. 2016 Apr;36(4):500-5
27113177
Diabetologia. 2010 Jan;53(1):58-65
19882137
Curr Diabetes Rev. 2012 Mar;8(2):109-15
22268397
J Diabetes Investig. 2017 May;8(3):306-313
27689345
J Neurol Sci. 2012 Nov 15;322(1-2):152-6
22871541
Diabetes. 2007 Jan;56(1):211-6
17192484
Lancet. 2006 Jul 29;368(9533):387-403
16876668
Arch Neurol. 2006 Nov;63(11):1551-5
17101823
Neuroscience. 2008 Jun 2;153(4):929-34
18434026
Behav Brain Res. 2009 Sep 14;202(2):308-11
19463714
J Neuropsychiatry Clin Neurosci. 2002 Fall;14(4):377-405
12426407
J Clin Neurol. 2015 Jan;11(1):48-56
25628737
Psychosom Med. 2015 Jul-Aug;77(6):631-42
25469685
Nat Neurosci. 2006 Mar;9(3):381-8
16491079
J Clin Exp Neuropsychol. 2004 Nov;26(8):1044-80
15590460
J Neurol. 2012 Jul;259(7):1303-11
22186849
World J Diabetes. 2014 Dec 15;5(6):889-93
25512792