Shigellosis murine model established by intraperitoneal and intranasal route of administration: a comparative comprehension overview.
Shigellosis, a major cause of mortality and morbidity, requires development of effective intervention strategy for which animal model mimicking human pathology is essential. Among various animal models for shigellosis, mice being more convenient have been used wherein intraperitoneal and intranasal routes are preferred. With the aim to comprehend the comparative pathophysiological indicators, we have examined relatively high and low dose of Shigella flexneri administered through intraperitoneal and intranasal routes in mice. Characterization of these two models along with the resulting pathophysiology of shigellosis adds to our understanding and offers suitable models appropriate to the objectives of the study.
Department of Cell and Molecular Biology, B.V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Ahmedabad, 380054, Gujarat, India; BRD School of Bioscience, Sardar Patel University, Vallabh Vidhyanagar, 388120, Gujarat, India.
Drashya
D
Sharma
Department of Cell and Molecular Biology, B.V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Ahmedabad, 380054, Gujarat, India; BRD School of Bioscience, Sardar Patel University, Vallabh Vidhyanagar, 388120, Gujarat, India.
Bhrugu
B
Yagnik
Department of Pharmacology and Toxicology, B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Ahmedabad, 380054, Gujarat, India.
Ruma
R
Baksi
CPL Biologicals Pvt. Ltd., Gujarat, India.
Nirav
N
Desai
Sardar Patel University, Vallabh Vidhyanagar, 388120, Gujarat, India.
Harish
H
Padh
Department of Cell and Molecular Biology, B.V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Ahmedabad, 380054, Gujarat, India. Electronic address: preetindesai79@gmail.com.
Priti
P
Desai
D000284:Administration, Oral; D000818:Animals; D004195:Disease Models, Animal; D004405:Dysentery, Bacillary / Q000382:microbiology* / Q000473:pathology*; D005260:Female; D007274:Injections, Intraperitoneal; D008807:Mice, Inbred BALB C; D012763:Shigella flexneri / Q000472:pathogenicity*
Comparative; Intranasal; Intraperitoneal; Murine model; Pathophysiology; Shigellosis