Super-Anticoagulant Heparin-Mimicking Hydrogel Thin Film Attached Substrate Surfaces to Improve Hemocompatibility.
In this study, heparin-mimicking hydrogel thin films are covalently attached onto poly(ether sulfone) membrane surfaces to improve anticoagulant property. The hydrogel films display honeycomb-like porous structure with well controlled thickness and show long-term stability. After immobilizing the hydrogel films, the membranes show excellent anticoagulant property confirmed by the activated partial thromboplastin time values exceeding 600 s. Meanwhile, the thrombin time values increase from 20 to 61 s as the sodium allysulfonate proportions increase from 0 to 80 mol%. In vitro investigations of protein adsorption and blood-related complement activation also confirm that the membranes exhibit super-anticoagulant property. Furthermore, gentamycin sulfate is loaded into the hydrogel films, and the released drug shows significant inhibition toward E. coli bacteria. It is believed that the surface attached heparin-mimicking hydrogel thin films may show high potential for the applications in various biological fields, such as blood contacting materials and drug loading materials.
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, People's Republic of China.
Min
M
He
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, People's Republic of China.
Xiaofei
X
Cui
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, People's Republic of China.
Huiyi
H
Jiang
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, People's Republic of China.
Xuelian
X
Huang
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, People's Republic of China.|Fiber and Polymer Technology, School of Chemical Science and Engineering, Royal Institute of Technology (KTH), Teknikringen 56-58, SE-100 44, Stockholm, Sweden.
Weifeng
W
Zhao
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, People's Republic of China.
Changsheng
C
Zhao
D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000925:Anticoagulants / Q000494:pharmacology*; D040761:Biomimetic Materials / Q000494:pharmacology*; D003167:Complement Activation / Q000187:drug effects; D005839:Gentamicins / Q000494:pharmacology; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000494:pharmacology*; D057927:Hydrophobic and Hydrophilic Interactions; D008297:Male; D008422:Materials Testing / Q000379:methods*; D008567:Membranes, Artificial; D018625:Microscopy, Atomic Force; D011108:Polymers / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared; D013450:Sulfones / Q000494:pharmacology; D013499:Surface Properties; D014867:Water / Q000737:chemistry
D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D005839:Gentamicins; D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; D014867:Water; C022840:polyether sulfone; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D006493:Heparin
anticoagulation; heparin-mimicking; hydrogel thin films; hydrogels; poly(ether sulfone)