Speech outcomes in Parkinson's disease after subthalamic nucleus deep brain stimulation: A systematic review.
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is effective in reducing motor symptoms for many individuals with Parkinson's disease (PD). However, STN DBS does not appear to influence speech in the same way, and may result in a variety of negative outcomes for people with PD (PWP). A high degree of inter-individual variability amongst PWP regarding speech outcomes following STN DBS is evident in many studies. Furthermore, speech studies in PWP following STN DBS have employed a wide variety of designs and methodologies, which complicate comparison and interpretation of outcome data amongst studies within this growing body of research. An analysis of published evidence regarding speech outcomes in PWP following STN DBS, according to design and quality, is missing. This systematic review aimed to analyse and coalesce all of the current evidence reported within observational and experimental studies investigating the effects of STN DBS on speech. It will strengthen understanding of the relationship between STN DBS and speech, and inform future research by highlighting methodological limitations of current evidence.
School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia; Asia Pacific Centre for Neuromodulation, Queensland Brain Institute, The University of Queensland, Brisbane, Australia.
Danielle
D
Aldridge
School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia. Electronic address: d.theodoros@uq.edu.au.
Deborah
D
Theodoros
School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia.
Anthony
A
Angwin
Centre for Neuroscience of Speech, The University of Melbourne, Melbourne, Australia; Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tübingen, Germany.
Adam P
AP
Vogel
D046690:Deep Brain Stimulation / Q000379:methods*; D006801:Humans; D010300:Parkinson Disease / Q000150:complications* / Q000628:therapy; D013064:Speech Disorders / Q000209:etiology* / Q000628:therapy*; D020531:Subthalamic Nucleus / Q000502:physiology*
Deep brain stimulation; Parkinson's disease; Speech; Subthalamic nucleus