ST2 and Galectin-3: Ready for Prime Time?
ST2 and galectin-3 are emerging biomarkers in the field of heart failure and have been extensively studied, and that whether they provide additional prognostic value on top of the clinical models and the gold standard in HF, (NT-pro)BNP. Our aim was to provide a comprehensive review of these emerging HF-related biomarkers in chronic, acute and incident heart failure. Regardless of the type of heart failure, both biomarkers seem to have an additional effect on top of the clinical model including natriuretic peptides. Strategies that combine multiple biomarkers may ultimately prove to be beneficial in the guidance of HF therapy in the future. However, additional prognostic value appears to be limited, and what we need is to prospectively test the consistent observations, which then might lead to the implementation of ST2 and galectin-3 in heart failure algorithms.
University Medical Center Groningen, University of Groningen , The Netherlands.
Wouter C
WC
Meijers
University Medical Center Groningen, University of Groningen , The Netherlands.
A Rogier
AR
van der Velde
University Medical Center Groningen, University of Groningen , The Netherlands.
Rudolf A
RA
de Boer
ST2; biomarkers; galectin-3; heart failure; prognosis
Eur Heart J. 2012 Sep;33(18):2290-6
22513778
J Am Coll Cardiol. 2009 Dec 1;54(23):2174-9
19942089
Am Heart J. 2012 Dec;164(6):878-83
23194488
Cardiovasc Drugs Ther. 2014 Jun;28(3):237-46
24789662
Expert Rev Mol Diagn. 2014 Apr;14(3):257-66
24606321
JACC Heart Fail. 2014 Jun;2(3):260-8
24952693
Eur J Heart Fail. 2012 Jan;14(1):32-8
22179033
Eur Heart J. 2012 Jul;33(14):1787-847
22611136
Clin Chem Lab Med. 2014 Jun;52(6):919-26
24445238
Clin Chim Acta. 2012 Oct 9;413(19-20):1493-4
22743282
J Am Coll Cardiol. 2014 Jan 21;63(2):158-66
24076531
Circulation. 2003 Feb 11;107(5):721-6
12578875
Am Heart J. 2014 May;167(5):674-82.e1
24766977
Circ Heart Fail. 2011 Mar;4(2):180-7
21178018
Am J Cardiol. 2015 Apr 2;115(7 Suppl):26B-31B
25665762
Am J Cardiol. 2015 Apr 2;115(7 Suppl):70B-5B
25670638
J Am Heart Assoc. 2012 Oct;1(5):e000760
23316284
J Am Coll Cardiol. 2008 Nov 11;52(20):1640-8
18992654
J Card Fail. 2008 Nov;14(9):732-8
18995177
J Am Coll Cardiol. 2007 Aug 14;50(7):607-13
17692745
Circ Heart Fail. 2013 Nov;6(6):1206-13
24114865
Am J Cardiol. 2011 Aug 1;108(3):385-90
21600537
Clin Res Cardiol. 2010 May;99(5):323-8
20130888
PLoS One. 2014 Sep 02;9(9):e95254
25180794
Am Heart J. 2010 Oct;160(4):721-8
20934567
Clin Biochem. 2010 May;43(7-8):683-90
20153309
Circulation. 2004 Nov 9;110(19):3121-8
15520318
Am J Med. 2006 Dec;119(12 Suppl 1):S3-S10
17113398
Clin Chim Acta. 2015 Mar 30;443:48-56
25446877
Eur J Heart Fail. 2014 Mar;16(3):350-4
24464746
J Card Fail. 2014 Jan;20(1):38-44
24304938
Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):67-75
23117656
Circ Heart Fail. 2012 Jan;5(1):72-8
22016505
Int J Cardiol. 2015 Mar 1;182:168-70
25577755
J Am Heart Assoc. 2014 Sep 18;3(5):e000962
25237044
Heart. 2000 May;83(5):596-602
10768918
Circulation. 2002 Dec 10;106(24):3068-72
12473553
JACC Heart Fail. 2014 Feb;2(1):65-72
24622120
Heart. 2003 Jun;89(6):605-9
12748212
Clin Chem. 2013 Mar;59(3):536-46
23220272
Clin Res Cardiol. 2015 Jun;104(6):491-9
25586507
Circ Heart Fail. 2013 Nov;6(6):1172-9
24103327
Circulation. 2012 Sep 25;126(13):1596-604
22907935
Am Heart J. 2015 Mar;169(3):404-411.e3
25728731
Am Heart J. 2014 Jun;167(6):853-60.e4
24890535
Circulation. 2013 Oct 15;128(16):e240-327
23741058
JACC Heart Fail. 2013 Jun;1(3):213-5
24621872
Nat Rev Drug Discov. 2008 Oct;7(10):827-40
18827826
Int J Cardiol. 2015 Aug 1;192:33-9
25985013
Eur Heart J. 2006 Jan;27(1):65-75
16219658
Clin Chim Acta. 2009 Nov;409(1-2):96-9
19747906
J Am Coll Cardiol. 2004 May 5;43(9):1590-5
15120816
Heart. 2014 Nov;100(21):1715-21
25080471
J Am Coll Cardiol. 2006 Sep 19;48(6):1217-24
16979009
J Am Coll Cardiol. 2012 Oct 23;60(17):1668-77
23021334
Clin Chim Acta. 2009 Nov;409(1-2):33-40
19699192
JACC Heart Fail. 2015 Jan;3(1):50-58
25458175
Clin Chim Acta. 2014 Feb 15;429:189-93
24365381
Eur Heart J. 2013 May;34(19):1424-31
23470495
Int J Cardiol. 2014;172(1):e250-2
24467978
J Am Coll Cardiol. 2013 Jan 15;61(2):121-6
23273288
Eur J Pharmacol. 2015 Sep 15;763(Pt A):115-21
26101067
J Am Coll Cardiol. 2010 Feb 16;55(7):645-53
20170790
Eur J Heart Fail. 2012 Mar;14(3):268-77
22302661
Am J Kidney Dis. 2003 Mar;41(3):571-9
12612980
Eur J Heart Fail. 2015 Jun;17(6):559-69
25880523
Eur J Heart Fail. 2013 May;15(5):511-8
23291728
Circ Heart Fail. 2013 Jan;6(1):107-17
23230309
Circ Heart Fail. 2009 Jul;2(4):311-9
19808354
Ann Med. 2011 Feb;43(1):60-8
21189092
Am J Cardiol. 2011 Jan 15;107(2):259-67
21211603
Clin Res Cardiol. 2013 Feb;102(2):103-10
22886030
Eur J Heart Fail. 2013 Jul;15(7):808-17
23537547
Circulation. 2004 Feb 10;109(5):594-600
14769680
Curr Heart Fail Rep. 2012 Dec;9(4):369-74
22940871
J Am Soc Nephrol. 2013 Sep;24(9):1470-7
23766533
J Am Coll Cardiol. 2012 Oct 2;60(14):1249-56
22939561