The effect of luteal phase gonadotropin-releasing hormone antagonist administration on IVF outcomes in women at risk of OHSS.
BACKGROUND
Gonadotropin-releasing hormone (GnRH) plays essential roles in embryo implantation, invasion of trophoblastic tissue, and steroid synthesis in the placenta.


OBJECTIVE
The aim of this study was to evaluate the effect of GnRH antagonist administration on pregnancy outcomes in early implantation period.


METHODS
In this retrospective study, 94 infertile women undergoing GnRH antagonist protocol who were at risk of ovarian hyperstimulation syndrome (OHSS) were included. Sixty-seven patients (group I) received Cetrorelix 0.25 mg/daily in the luteal phase for 3 days while in 27 participants (group II), it was not administered. Pregnancy outcomes were assessed based on chemical and clinical pregnancy rates.


RESULTS
The pregnancy outcomes were not significantly different between two groups (p=0.224).


CONCLUSIONS
The present study proposed that luteal phase GnRH antagonist administration does not influence the chance of successful pregnancy outcomes.
Research and Clinical Center for Infertility, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Maryam
M
Eftekhar
Research and Clinical Center for Infertility, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.; Department of Obstetrics and Gynecology, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Sepideh
S
Miraj
Research and Clinical Center for Infertility, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Zahrasadat
Z
Mortazavifar
Gonadotropin-releasing hormone antagonist; In vitro fertilization; Pregnancy outcome
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