Serum hs-CRP varies with dietary cholesterol, but not dietary fatty acid intake in individuals free of any history of cardiovascular disease.
The objective of this study was to investigate whether serum high-sensitivity C-reactive protein (hs-CRP) concentration varies with dietary fatty acid intake in Iranian adults free of any history of cardiovascular disease (CVD). This cross-sectional study involved 8105 adults (3142 men) aged 35-65 years. Dietary intake was assessed using 24-h dietary recalls. The relationship between anthropometric, cardiometabolic risk factors and dietary data and serum hs-CRP was assessed using SPSS software. Median crude dietary saturated fat decreased across hs-CRP quarters (P =0.009 for linear trend), whereas energy-adjusted total fat (P =0.017), trans-fat (P =0.016), monounsaturated fatty acids (P =0.030) and cholesterol (P =0.005) monotonically increased, with some evidence of statistical interactions by gender. In conclusion, serum hs-CRP concentrations were associated with some components of dietary fatty acid intake in our population of individuals without CVD, suggesting that dietary fat intake could be associated with subclinical inflammation.
Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.|Institute of Genetics and Developmental Biology, International College, University of Chinese Academy of Science (IC-UCAS), Beijing, China.
M
M
Mazidi
Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
A
A
Heidari-Bakavoli
Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
S S
SS
Khayyatzadeh
Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
M R
MR
Azarpazhooh
Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
M
M
Nematy
Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
M
M
Safarian
Department of Statistics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
H
H
Esmaeili
Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
S M R
SM
Parizadeh
Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
M
M
Ghayour-Mobarhan
Non-Communicable Disease Research Unit, South African Medical Research Council and University of Cape Town, Cape Town, South Africa.
A P
AP
Kengne
Brighton & Sussex Medical School, Division of Medical Education, University of Brighton, Brighton, UK.
G A
GA
Ferns
D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000097:blood*; D002791:Cholesterol, Dietary / Q000097:blood*; D003430:Cross-Sectional Studies; D004041:Dietary Fats / Q000008:administration & dosage; D004435:Eating / Q000502:physiology*; D005227:Fatty Acids / Q000008:administration & dosage / Q000097:blood*; D005260:Female; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D002791:Cholesterol, Dietary; D004041:Dietary Fats; D005227:Fatty Acids; D002097:C-Reactive Protein
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