Fresh versus cryopreserved oocyte donation.
OBJECTIVE
Utilization of cryopreserved instead of fresh donor oocytes has rapidly increased in recent years. Whether treatment outcomes are comparable has, however, remained controversial.


RESULTS
More than 24% of initiated oocyte donation cycles in the USA during 2013-2014 involved previously cryopreserved oocytes. The use of cryopreserved-donated oocytes may simplify logistics and lower costs per treatment cycle. Whether cryopreserved donor oocytes also lower costs per live birth is still undetermined as they result in lower live birth rates in comparison to fresh donor oocyte cycles. National data regarding the safety of donated oocytes, including miscarriage rates and neonatal health outcomes, are lacking.


CONCLUSIONS
Currently available data on cryopreserved-donated oocytes are incomplete and, therefore, still insufficient to claim equivalency between fresh and cryopreserved donor oocytes. Until sufficient data are available, patients should be advised about advantages and disadvantages of both methods of oocyte donation, and the use of cryopreserved oocytes should be considered only with caution and appropriate informed consent. Because banking of donated human oocytes facilities their commercial trade, it challenges basic ethical considerations, which have been the basis of oocyte donation since its inception.
aThe Center for Human Reproduction, New York, New York bWake Forest School of Medicine, Winston-Salem, North Carolina cFoundation for Reproductive Medicine dThe Rockefeller University, New York, New York, USA.
Vitaly A
VA
Kushnir
Norbert
N
Gleicher
D000328:Adult; D015925:Cryopreservation / Q000379:methods; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D018587:Oocyte Donation / Q000379:methods*; D009865:Oocytes / Q000502:physiology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D016896:Treatment Outcome