Resolution of a disputed albendazole result in the UK Official Control System - time for more guidance?
Albendazole, one of the benzimidazole anthelmintics, is used in ruminants and has maximum residue limits in muscle, fat and other tissue owing to reported teratogenicity. Albendazole is extensively metabolised in domestic animals and humans with rapid conversion to a sulphoxide and subsequently sulphone and amino sulphone metabolites. Sulphoxide metabolites are responsible for the systemic biological activity of benzimidazole drugs. Herein we report a case of disputed results for albendazole in a consignment sampled at import in which the Official Analyst certified against the consignment for excess albendazole. A laboratory acting for the importer reported data below the MRL, including a finding of the parent drug which is not included in the residue definition. The Government Chemist has a statutory duty as a route of technical appeal in the UK Official Food Control system and the case was referred for referee analysis. We report our findings based on a LC-MS/MS method, which confirmed the official findings, did not reveal the presence of the parent drug but identified hot spots of albendazole marker residues in the consignment. We discuss the need for recommendations on official sampling at import and interpretation of results.
a Government Chemist Programme , LGC , Teddington , UK.
Michael
M
Walker
a Government Chemist Programme , LGC , Teddington , UK.
Kirstin
K
Gray
b Science & Innovation Division , Teddington , UK.
Christopher
C
Hopley
b Science & Innovation Division , Teddington , UK.
Christopher
C
Mussell
c Laboratory and Managed Services , LGC , Teddington , UK.
Louise
L
Clifford
c Laboratory and Managed Services , LGC , Teddington , UK.
Jayanie
J
Meinerikandathevan
c Laboratory and Managed Services , LGC , Teddington , UK.
Leonardo
L
Firpo
c Laboratory and Managed Services , LGC , Teddington , UK.
Joanna
J
Topping
d London Port Health Authority, Stanford-Le-Hope , Essex , UK.
Daniel
D
Santacruz
D015766:Albendazole / Q000032:analysis* / Q000378:metabolism; D000818:Animals; D000871:Anthelmintics / Q000032:analysis* / Q000378:metabolism; D001711:Biotransformation; D002417:Cattle; D002853:Chromatography, Liquid; D034462:Dissent and Disputes / Q000331:legislation & jurisprudence*; D004350:Drug Residues / Q000032:analysis* / Q000378:metabolism; D057141:Food, Preserved / Q000032:analysis; D017408:Guidelines as Topic; D006801:Humans; D008460:Meat / Q000032:analysis*; D011786:Quality Control; D013450:Sulfones / Q000032:analysis / Q000378:metabolism; D013454:Sulfoxides / Q000032:analysis / Q000378:metabolism; D053719:Tandem Mass Spectrometry; D006113:United Kingdom
D000871:Anthelmintics; D013450:Sulfones; D013454:Sulfoxides; D015766:Albendazole
Albendazole; corned beef; law; sampling; technical appeal