Serum B-cell activating factor predicts prognosis in nasal type, extranodal NK/T cell lymphoma.
B-cell activating factor (BAFF) plays important roles in a variety of lymphoid malignancies. Compared with healthy adults, patients with non-Hodgkin lymphoma had higher level of serum BAFF, and it corresponded with disease severity, response for therapy and clinical outcome. Latent membrane protein 1 (LMP1) encoded by Epstein-Barr virus (EBV) which is a known agent of nasal, extranodal NK/T cell lymphoma (ENKTCL) can switch the BAFF activating promoter leading to higher expression of BAFF in EBV-related tumor cells. However, the relationship between BAFF and ENKTCL has not been reported. Here we proposed a hypothesis that BAFF might play a regulatory role in ENKTCL development and maintenance. Our results showed that serum BAFF in ENKTCL patients was significantly higher than that in control group and negatively correlated with patients' survival. It may be a valuable prognostic factor and deserved further study.
Department of Medical Oncology, Cancer Center, West China Hospital of Sichuan University, Chengdu, China; Department of Oncology, Dujiangyan Medical Center, Dujiangyan, Sichuan, China.
Li
L
Zhang
Department of Medical Oncology, Cancer Center, West China Hospital of Sichuan University, Chengdu, China.
Na
N
Li
State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China.
Li
L
Yang
Department of Medical Oncology, Cancer Center, West China Hospital of Sichuan University, Chengdu, China.
Jing
J
Zhang
Department of Medical Oncology, Cancer Center, West China Hospital of Sichuan University, Chengdu, China.
Hua-Wei
HW
Weng
Department of Medical Oncology, Cancer Center, West China Hospital of Sichuan University, Chengdu, China; State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China. Electronic address: zliqun@hotmail.com.
Li-Qun
LQ
Zou
D053264:B-Cell Activating Factor / Q000097:blood*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D054391:Lymphoma, Extranodal NK-T-Cell / Q000097:blood* / Q000401:mortality*; D008297:Male; D009363:Neoplasm Proteins / Q000097:blood*; D015996:Survival Rate
D053264:B-Cell Activating Factor; D009363:Neoplasm Proteins; C505719:TNFSF13B protein, human
B cell activating factor (BAFF); Extranodal NK/T cell lymphoma (ENKTCL); Nasal type; Prognosis