Parathyroid carcinoma in tertiary hyperparathyroidism.
Parathyroid carcinoma is a rare disease of unknown etiology. This study presents a case of parathyroid carcinoma in a patient with tertiary hyperparathyroidism. Despite a successful kidney transplantation, the intact parathyroid hormone (iPTH) level of the patient was elevated consistently and could not be controlled by medical therapy. Due to the development of tertiary hyperparathyroidism with bone pain and osteoporosis, subtotal parathyroidectomy was performed 4 months after the kidney transplantation. Histological evaluation revealed that one of four parathyroid lesions was a parathyroid carcinoma, while the others were diffuse hyperplasia. Postoperative laboratory studies indicated a decreased level of iPTH. A positron emission tomography-computed tomography performed 6 months after the operation revealed no evidence of local recurrence or distant metastasis.
Department of Surgery, Chung-Ang University, College of Medicine, Chung-Ang University Hospital, Seoul, South Korea.
Byung Seup
BS
Kim
Department of Pathology, Chung-Ang University, College of Medicine, Chung-Ang University Hospital, Seoul, South Korea.
Han Suk
HS
Ryu
Department of Surgery, Chung-Ang University, College of Medicine, Chung-Ang University Hospital, Seoul, South Korea. Electronic address: kgiseup@naver.com.
Kyung Ho
KH
Kang
Department of Surgery, Chung-Ang University, College of Medicine, Chung-Ang University Hospital, Seoul, South Korea.
Sung Jun
SJ
Park
D002277:Carcinoma / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D006961:Hyperparathyroidism / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010282:Parathyroid Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D016105:Parathyroidectomy; D011183:Postoperative Complications / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery
kidney transplantation; parathyroid carcinoma