Long-term systemic lupus erythematosus disease control after allogeneic bone marrow transplantation.
Systemic lupus erythematosus (SLE), a disorder of the immune system, is potentially curable by allogeneic bone marrow transplantation (alloBMT). Until recently, alloBMT was limited by donor availability and toxicity. Reduced intensity conditioning (RIC) combined with post-transplantation cyclophosphamide (PTCy) has improved the availability and safety of alloBMT permitting its exploration in severe-refractory autoimmune illnesses. We report the six-year follow-up of a young female whose refractory SLE-associated nephrosis resolved after RIC alloBMT with PTCy.
Johns Hopkins Hospital and Health System, Baltimore, MD, USA.
D E
DE
Gladstone
Johns Hopkins Hospital and Health System, Baltimore, MD, USA.
M
M
Petri
Johns Hopkins Hospital and Health System, Baltimore, MD, USA.
J
J
Bolaños-Meade
Johns Hopkins Hospital and Health System, Baltimore, MD, USA.
A E
AE
Dezern
Johns Hopkins Hospital and Health System, Baltimore, MD, USA.
R J
RJ
Jones
Johns Hopkins Hospital and Health System, Baltimore, MD, USA.
D
D
Fine
Johns Hopkins Hospital and Health System, Baltimore, MD, USA.
R A
RA
Brodsky
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000379:methods*; D003520:Cyclophosphamide / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008180:Lupus Erythematosus, Systemic / Q000503:physiopathology / Q000628:therapy*; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide
Systemic lupus erythematosus; alloBMT
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