Correlation between serum leptin and bone mineral density in hemodialysis patients.
BACKGROUND
For diagnosing of specific types of bone lesions in hemodialysis (HD) patients, it is necessary to conduct a bone biopsy as the gold standard method. However, it is an invasive procedure. While different markers have been suggested as alternative methods, none of them has been selected. The frequency of hip fractures is 80 fold in HD patients who have two-fold mortality as compared with general population.


OBJECTIVE
Recently, serum leptin has been suggested as a bone density marker. This study tries to confirm this proposal.


METHODS
In this study about 104 HD patients (53.8% male and 46.2% female) were enrolled. The average age was 38.28±7.89 years. Serum leptin, bone alkaline phosphatase, intact parathyroid hormone (iPTH), 25(OH)D, calcium, phosphorus and bone mineral density (BMD) (at the femoral neck and lumbar spine, as measured by dual-energy x-ray absorptiometry [DXA]) were assessed.


RESULTS
Analysis by polynomial regression revealed no correlation between BMD Z-score at two points and serum leptin level. According to the thresholds of 25 ng/mL and 18-24 ng/mL in some studies, we detected 25 ng/mL as the threshold in our patients. Under this threshold, the leptin effect on bone mass was negative, and above the threshold of 25 ng/mL, we found leptin had positive effect on bone mass.


CONCLUSIONS
In this investigation, we found, leptin has a bimodal effect on bone mass. Cortical bones assessment may be a better option for assessment.
Kidney Transplantation Complications Research Center, Montaseriyeh Organ Transplantation Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Mahin
M
Ghorban-Sabbagh
Nephrology Section, Department of Internal Medicine, Imam-Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Fatemeh
F
Nazemian
Nephrology Section, Department of Internal Medicine, Imam-Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Massih
M
Naghibi
Department of Community Medicine and Public Health, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad-Taghi
MT
Shakeri
Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Saeedeh
S
Ahmadi-Simab
Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Reza
R
Javidi-Dasht-Bayaz
Bone mineral density; Dual-energy x-ray absorptiometry; Hemodialysis; Leptin
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