[Survival of patients with pulmonary arterial hypertension after the advent of specific pulmonary vasodilator therapies].
BACKGROUND
Pulmonary arterial hypertension (PAH) is a rare and progressive disease. Long-term survival remains poor despite of advances in specific vasodilator therapy.


OBJECTIVE
To describe the survival rate in a cohort of PAH patients in two referral centers in Chile.


METHODS
One hundred fifteen patients aged 43 ± 15.6 years (85% females) with PAH qualified for this study. Their median pulmonary artery pressure was 55.4 ± 14 mmHg and their six minutes walking capacity was 368 ± 119 m. They were followed for 58 ± 0.4 months and their actual survival rates were compared with the estimated survival using the equation proposed by the French registry of PAH.


RESULTS
One, two and three year survival rates were 97, 94 and 89%, respectively. The observed survival rates were greater than the estimated survival.


CONCLUSIONS
The improvement in survival rates observed in this cohort of patients is similar to what has been described in literature.
Hospital Clínico, Pontificia Universidad Católica de Chile, Santiago, Chile.
Sebastián
S
Herrera
Hospital Clínico, Pontificia Universidad Católica de Chile, Santiago, Chile.
Luigi
L
Gabrielli
Hospital Clínico, Pontificia Universidad Católica de Chile, Santiago, Chile.
Alejandro
A
Paredes
Hospital Clínico, Pontificia Universidad Católica de Chile, Santiago, Chile.
Rodrigo
R
Saavedra
Hospital Clínico, Pontificia Universidad Católica de Chile, Santiago, Chile.
María Paz
MP
Ocaranza
Hospital San Juan de Dios, Chile.
Pablo
P
Sepúlveda
Hospital San Juan de Dios, Chile.
Hernán
H
Donoso
Hospital San Juan de Dios, Chile.
Leonel
L
López
Hospital Clínico, Pontificia Universidad Católica de Chile, Santiago, Chile.
Hugo
H
Verdejo
Hospital Clínico, Pontificia Universidad Católica de Chile, Santiago, Chile.
Fernando
F
Baraona
Hospital Clínico, Pontificia Universidad Católica de Chile, Santiago, Chile.
Pablo
P
Castro
D000328:Adult; D002677:Chile; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000401:mortality*; D008297:Male; D012189:Retrospective Studies; D015996:Survival Rate; D014665:Vasodilator Agents / Q000008:administration & dosage*
D014665:Vasodilator Agents