Separation properties of the MIL-125(Ti) Metal-Organic Framework in high-performance liquid chromatography revealing cis/trans selectivity.
Monodisperse MIL-125(Ti) Metal-Organic Framework crystals were synthesized and studied as stationary phase in high performance liquid chromatography (HPLC). Different pure compounds and model mixtures (including stereoisomer mixtures) were injected from which chromatographic parameters, including selectivities and resolution factors, were determined to evaluate the adsorption properties and separation performance of MIL-125(Ti) in liquid phase. The MIL-125(Ti) framework displayed a trans selectivity for cis/trans difunctionalized cyclohexane molecules with high selectivity and resolution for 1,3-dimethylcyclohexane and 4-ethylcyclohexanol. The slurry-packed column was further characterized via van Deemter analysis. Fitting of the van Deemter equation through the experimental points allowed to define the contributions of the different processes to plate height with a significant proportion of the A-term, reflecting the importance of a good crystal packing. Although high in comparison to commercial HPLC stationary phases, a very good plate height of around 50μm was found.
Department of Chemical Engineering, Vrije Universiteit Brussel, Pleinlaan 2, Brussel B1050, Belgium.
Stijn
S
Van der Perre
Department of Chemical Engineering, Vrije Universiteit Brussel, Pleinlaan 2, Brussel B1050, Belgium.
Anuschka
A
Liekens
Centre of Surface Chemistry and Catalysis, Katholieke Universiteit Leuven, Celestijnenlaan 200F - box 2461, Leuven 3001, Belgium.
Bart
B
Bueken
Centre of Surface Chemistry and Catalysis, Katholieke Universiteit Leuven, Celestijnenlaan 200F - box 2461, Leuven 3001, Belgium.
Dirk E
DE
De Vos
Department of Chemical Engineering, Vrije Universiteit Brussel, Pleinlaan 2, Brussel B1050, Belgium.
Gino V
GV
Baron
Department of Chemical Engineering, Vrije Universiteit Brussel, Pleinlaan 2, Brussel B1050, Belgium. Electronic address: Joeri.Denayer@vub.ac.be.
Joeri F M
JF
Denayer
D000327:Adsorption; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003510:Cyclohexanes / Q000032:analysis; D003998:Dicarboxylic Acids / Q000737:chemistry*; D009930:Organic Chemicals / Q000032:analysis*; D009942:Organometallic Compounds / Q000737:chemistry*; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis; D013237:Stereoisomerism; D014025:Titanium
D003510:Cyclohexanes; D003998:Dicarboxylic Acids; D009930:Organic Chemicals; D009942:Organometallic Compounds; D011084:Polycyclic Aromatic Hydrocarbons; D014025:Titanium
MIL-125(Ti); Metal-Organic Frameworks; Modulated synthesis; cis/trans selectivity; van Deemter