The Efficacy and Safety of Tetrachlorodecaoxide in Comparison with Super-oxidised Solution in Wound Healing.
BACKGROUND
Some of the relatively newer, more efficacious, and potent topical wound dressing solutions include tetrachlorodecaoxide and super-oxidised solution. This study compares the efficacy and safety of these two drugs.


METHODS
This is a block-randomised, double blind, parallel-arm, post-marketing study. One hundred fifty patients with ulcers (75 blocks uniform for sex, ulcer aetiology, diabetes mellitus, and wound area score) were randomised into the two treatment arms. Patients were observed for eight weeks with weekly assessments. One hundred and twenty patients completed the study. Wound healing was objectively assessed by measurement of wound area, scoring of wound exudation and tissue type, and using the pressure ulcer scale of healing Tool (validated for multiple wound aetiologies). Subjective improvement in pain was noted using a visual analogue scale. Both groups were compared using Mann-Whitney U test on all indicators.


RESULTS
Difference in change in wound tissue type in the two groups was significant (α=0.05) by intention-to-treat (ITT) and per-protocol (PP) analysis at the end of week two (ITT and PP, P<0.001) and week four (ITT, P=0.010; PP, P=0.009). P-values for other comparisons were not significant (P>0.05). No study-related adverse events were observed.


CONCLUSIONS
Both drugs are efficacious. Tetrachlorodecaoxide yields healthy granulation tissue earlier. Both drugs appear to be safe for application.
Department of Surgery, Grant Government Medical College, Mumbai, India.
Romil
R
Parikh
Department of Surgery, Grant Government Medical College, Mumbai, India.
Girish
G
Bakhshi
Department of Surgery, Grant Government Medical College, Mumbai, India.
Madhushree
M
Naik
Department of Preventive and Social Medicine, Grant Government Medical College, Mumbai, India.
Bhargav
B
Gaikwad
Department of Surgery, Grant Government Medical College, Mumbai, India.
Kavita
K
Jadhav
Department of Surgery, Grant Government Medical College, Mumbai, India.
Mukund
M
Tayade
Superoxidized water; Tetrachlorodecaoxide; Ulcer; Wound healing
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