Atlas-based shape analysis and classification of retinal optical coherence tomography images using the functional shape (fshape) framework.
We propose a novel approach for quantitative shape variability analysis in retinal optical coherence tomography images using the functional shape (fshape) framework. The fshape framework uses surface geometry together with functional measures, such as retinal layer thickness defined on the layer surface, for registration across anatomical shapes. This is used to generate a population mean template of the geometry-function measures from each individual. Shape variability across multiple retinas can be measured by the geometrical deformation and functional residual between the template and each of the observations. To demonstrate the clinical relevance and application of the framework, we generated atlases of the inner layer surface and layer thickness of the Retinal Nerve Fiber Layer (RNFL) of glaucomatous and normal subjects, visualizing detailed spatial pattern of RNFL loss in glaucoma. Additionally, a regularized linear discriminant analysis classifier was used to automatically classify glaucoma, glaucoma-suspect, and control cases based on RNFL fshape metrics.
School of Engineering Science, Simon Fraser University, Burnaby, British Columbia, V5A 1S6, Canada.
Sieun
S
Lee
Center for Imaging Sciences (CIS), Johns Hopkins University, Baltimore, MD 21218, USA.
Nicolas
N
Charon
Institut Montpelliérain Alexander Grothendieck, Campus Triolet, Montpellier 34095, France.
Benjamin
B
Charlier
School of Engineering Science, Simon Fraser University, Burnaby, British Columbia, V5A 1S6, Canada.
Karteek
K
Popuri
School of Engineering Science, Simon Fraser University, Burnaby, British Columbia, V5A 1S6, Canada.
Evgeniy
E
Lebed
School of Engineering Science, Simon Fraser University, Burnaby, British Columbia, V5A 1S6, Canada.
Marinko V
MV
Sarunic
CMLA, ENS Cachan, CNRS, Université Paris-Saclay, Cachan 94235, France.
Alain
A
Trouvé
School of Engineering Science, Simon Fraser University, Burnaby, British Columbia, V5A 1S6, Canada. Electronic address: mfbeg@sfu.ca.
Mirza Faisal
MF
Beg
D000465:Algorithms; D001271:Atlases as Topic; D016022:Case-Control Studies; D005901:Glaucoma / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D012160:Retina / Q000033:anatomy & histology / Q000000981:diagnostic imaging*; D041623:Tomography, Optical Coherence / Q000379:methods*; D014794:Visual Fields
Atlas generation; Atlas-based shape analysis; Classification; Computational anatomy; Optical coherence tomography