Axial Length Measurement Failure Rates With Biometers Using Swept-Source Optical Coherence Tomography Compared to Partial-Coherence Interferometry and Optical Low-Coherence Interferometry.
OBJECTIVE
To compare a new swept-source optical coherence tomography (SSOCT)-based biometer (OA-2000) with the IOLMaster v5.4 (partial-coherence interferometry) and Aladdin (optical low-coherence interferometry) biometers in terms of axial length measurement and failure rate in eyes with cataract.


METHODS
Reliability study.


METHODS
A total of 377 eyes of 210 patients were scanned with the 3 biometers in a random order. For each biometer, the number of unobtainable axial length measurements was recorded and grouped as per the type and severity of cataract based on the Lens Opacities Classification System III by the same experienced ophthalmologist. The Bland-Altman limits-of-agreement (LoA) method was used to assess the agreement in axial length measurements between the 3 biometers.


RESULTS
The failure rate was 0 eyes (0%) with the OA-2000, 136 eyes (36.07%) with the IOLMaster, and 51 eyes (13.53%) with the Aladdin. χ2analyses indicated a significant difference in failure rate between all 3 devices (P < .001). Logistic regression analysis highlighted a statistically significant trend of higher failure rates with increasing severity of nuclear, cortical, and posterior subcapsular cataracts. Bland-Altman statistics indicated small mean differences and narrow LoA (OA-2000 vs IOLMaster -0.09 to 0.08 mm; OA-2000 vs Aladdin -0.10 to 0.07 mm; IOLMaster vs Aladdin -0.05 to 0.04 mm).


CONCLUSIONS
The OA-2000, a new SSOCT-based biometer, outperformed both the IOLMaster and Aladdin biometers in very advanced cataracts of various morphologies. The use of SSOCT technology may be the reason for the improved performance of the OA-2000 and may lead to this technology becoming the gold standard for the measurement of axial length.
School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China; ABM University Health Board, Swansea, United Kingdom; Discipline of Optometry and Vision Science, Flinders University of South Australia, Bedford Park, South Australia, Australia.
Colm
C
McAlinden
School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China; Key Laboratory of Vision Science, Ministry of Health Peoples Republic of China, Wenzhou, China.
Qinmei
Q
Wang
School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China; Key Laboratory of Vision Science, Ministry of Health Peoples Republic of China, Wenzhou, China.
Rongrong
R
Gao
School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China.
Weiqi
W
Zhao
School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China; Key Laboratory of Vision Science, Ministry of Health Peoples Republic of China, Wenzhou, China.
Ayong
A
Yu
School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China.
Yu
Y
Li
School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China.
Yan
Y
Guo
School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China; Key Laboratory of Vision Science, Ministry of Health Peoples Republic of China, Wenzhou, China. Electronic address: vip999vip@163.com.
Jinhai
J
Huang
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D058452:Axial Length, Eye / Q000033:anatomy & histology*; D001699:Biometry / Q000379:methods*; D002386:Cataract / Q000175:diagnosis*; D003951:Diagnostic Errors / Q000706:statistics & numerical data*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007368:Interferometry / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015203:Reproducibility of Results; D041623:Tomography, Optical Coherence / Q000379:methods*