Aetiology of PCR negative suspected Crimean-Congo hemorrhagic fever cases in an endemic area.
Crimean-Congo hemorrhagic fever (CCHF) is a potentially fatal tick-borne viral infection that is widely distributed worldwide. The diagnosis is frequently missed due to the non-specific initial symptoms and the differential diagnosis included many infectious and non-infectious causes. This retrospective study describes the clinical features and final diagnoses of 116 suspect CCHF cases that were admitted to a tertiary CCHF center in Turkey, and were CCHF IgM and PCR negative.
a Department of Infectious Disease and Clinical Microbiology , Ondokuz Mayıs University, Medical School , Samsun , Turkey.
Esra
E
Tanyel
a Department of Infectious Disease and Clinical Microbiology , Ondokuz Mayıs University, Medical School , Samsun , Turkey.
Mustafa
M
Sunbul
a Department of Infectious Disease and Clinical Microbiology , Ondokuz Mayıs University, Medical School , Samsun , Turkey.|b Liverpool School of Tropical Medicine , Liverpool , UK.
Tom E
TE
Fletcher
a Department of Infectious Disease and Clinical Microbiology , Ondokuz Mayıs University, Medical School , Samsun , Turkey.
Hakan
H
Leblebicioglu
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D019353:Endemic Diseases; D005260:Female; D006479:Hemorrhagic Fever, Crimean / Q000175:diagnosis* / Q000453:epidemiology; D006801:Humans; D007075:Immunoglobulin M; D008297:Male; D016133:Polymerase Chain Reaction; D012189:Retrospective Studies; D062606:Tertiary Care Centers; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult
D000914:Antibodies, Viral; D007075:Immunoglobulin M
Crimean–Congo hemorrhagic fever; Endemic area; Misdiagnosis; Viral hemorrhagic fever
Medicina (Kaunas). 2013;49(8):367-71
24509147
Int J Antimicrob Agents. 2010 Nov;36 Suppl 1:S43-6
20810253
Jpn J Infect Dis. 2015;68(2):131-4
25420643
Scand J Infect Dis. 2010 Jul;42(6-7):516-21
20166862
Indian J Med Microbiol. 2011 Oct-Dec;29(4):418-9
22120806
Mikrobiyol Bul. 2012 Jul;46(3):475-9
22951660
J Infect. 2016 Feb;72(2):253-5
26493271
J Med Virol. 2014 Jul;86(7):1188-92
24619972
J Hosp Infect. 2013 Mar;83(3):185-92
23333147
Vector Borne Zoonotic Dis. 2012 Sep;12(9):805-11
22607078
N Engl J Med. 2015 Jan 1;372(1):40-7
25372658
Int J Infect Dis. 2015 Sep;38:9-15
26183413
Int J Infect Dis. 2009 May;13(3):380-6
18986819
Mikrobiyol Bul. 2010 Jan;44(1):57-64
20455399
Epidemiol Infect. 2010 Jan;138(1):139-44
19580693
Antiviral Res. 2016 Feb;126:21-34
26695860
Clin Med (Lond). 2015 Feb;15(1):61-6
25650201
Emerg Infect Dis. 2015 Jan;21(1):23-31
25529825
J Infect. 2015 Nov;71(5):597-9
26196597
PLoS Negl Trop Dis. 2013 Sep 19;7(9):e2435
24069490