In Situ Observation of Single-Molecule Surface Reactions from Low to High Affinities.
In situ observation of single-molecule surface reactions from low to high affinities is achieved by resonant coupling between optical whispering-gallery modes and the localized surface plasmon of nanorods. Transient and permanent interactions between ligands (thiol, amine) and the gold surface are monitored without labels, allowing direct determination of the associated kinetic constants and rapid development of new functionalization protocols.
Max Planck Institute for the Science of Light, Günther-Scharowsky-Straβe 1, 91058, Erlangen, Germany.
Eugene
E
Kim
Max Planck Institute for the Science of Light, Günther-Scharowsky-Straβe 1, 91058, Erlangen, Germany.
Martin D
MD
Baaske
Max Planck Institute for the Science of Light, Günther-Scharowsky-Straβe 1, 91058, Erlangen, Germany.
Frank
F
Vollmer
ligands; plasmonic nanoparticles; single molecules; surface reactions; whispering-gallery modes