l-Arginine Enhances Resistance against Oxidative Stress and Heat Stress in Caenorhabditis elegans.
The antioxidant properties of l-arginine (l-Arg) in vivo, and its effect on enhancing resistance to oxidative stress and heat stress inCaenorhabditis eleganswere investigated.C. elegans, a worm model popularly used in molecular and developmental biology, was used in the present study. Here, we report that l-Arg, at a concentration of 1 mM, prolongedC. eleganslife by 26.98% and 37.02% under oxidative and heat stress, respectively. Further experiments indicated that the longevity-extending effects of l-Arg may be exerted by its free radical scavenging capacity and the upregulation of aging-associated gene expression in worms. This work is important in the context of numerous recent studies that concluded that environment stresses are associated with an increased population death rate.
Key laboratory for Molecular Enzymology and Engineering, The Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China. mahr13@mails.jlu.edu.cn.
Heran
H
Ma
Sports Science Research Institute of Jilin Province, Changchun 130022, China. yudanma@sina.cn.
Yudan
Y
Ma
Key laboratory for Molecular Enzymology and Engineering, The Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China. zhangzhixian_99@126.com.
Zhixian
Z
Zhang
Key laboratory for Molecular Enzymology and Engineering, The Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China. 18743025536@163.com.
Ziyuan
Z
Zhao
Key laboratory for Molecular Enzymology and Engineering, The Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China. avalinran@outlook.com.
Ran
R
Lin
The China-Japan Union Hospital of Jilin University, Changchun 130033, China. zhujinmingWT@163.com.
Jinming
J
Zhu
Key laboratory for Molecular Enzymology and Engineering, The Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China. guoyi@jlu.edu.cn.
Yi
Y
Guo
Key laboratory for Molecular Enzymology and Engineering, The Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China. xuli@jlu.edu.cn.
Li
L
Xu
">l-Arg; C. elegans; antiaging; antioxidant; free radical
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