The Growth Pattern of Tibetan Infants at High Altitudes: a Cohort Study in Rural Tibet region.
Studies on growth pattern of Tibetan infants and the difference from other child groups were limited due to its special living environment and unique customs. In this study, 253 Tibetan infants were followed-up from their birth to 12thmonth in rural Tibet. Five visits were conducted and weight and length were measured at each visit. Mixed model was employed to analyze the growth pattern of Tibetan infants and its comparison to the Han infants. Propensity Scores (PS) technique was adopted to control for the potential confounding factors. The mixed model found that the birth weight/length had a negative impact on the increment of Tibetan infants after birth (weight: β = -0.6819, P < 0.0001, length: β = -0.9571, P < 0.0001). The weight increment of Tibetan infants was greater than Han infant with age (βage*ethnic= 0.0345, P < 0.001), after using PS as a covariant. And another mixed model in which PS was used as a matching factor found similar trend. Compared with Chinese Han infants, Tibetan infants were lower weight and shorter length within one year after birth but they had greater increment of weight, suggesting that Tibetan infants might have a significant catch-up growth within the first year of life.
Shaanxi Center for Disease Control and Prevention, No. 3 Jian Dong Street, Xi'an, Shaanxi, People's Republic of China.|The Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, No. 76, Yanta West Road, Xi'an, Shaanxi, People's Republic of China.
Weihua
W
Wang
Shaanxi Center for Disease Control and Prevention, No. 3 Jian Dong Street, Xi'an, Shaanxi, People's Republic of China.
Feng
F
Liu
Shaanxi Center for Disease Control and Prevention, No. 3 Jian Dong Street, Xi'an, Shaanxi, People's Republic of China.
Zhicheng
Z
Zhang
Shaanxi Center for Disease Control and Prevention, No. 3 Jian Dong Street, Xi'an, Shaanxi, People's Republic of China.
Yi
Y
Zhang
The Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, No. 76, Yanta West Road, Xi'an, Shaanxi, People's Republic of China.
Xiaojing
X
Fan
Xi'an Center for Disease Control and Prevention, Shaanxi, No. 599, Xiying Road, Xi'an, Shaanxi, People's Republic of China.
Ruru
R
Liu
The Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, No. 76, Yanta West Road, Xi'an, Shaanxi, People's Republic of China.
Shaonong
S
Dang
D000531:Altitude; D002657:Child Development / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D008954:Models, Biological; D012424:Rural Population; D018609:Tibet / Q000208:ethnology
Proc R Soc Lond B Biol Sci. 1976 Aug 27;194(1114):83-98
11483
Ann Eugen. 1951 Sep;16(2):147-64
14885877
Eur J Clin Nutr. 2004 Jun;58(6):938-46
15164115
Zhonghua Yu Fang Yi Xue Za Zhi. 2004 Jul;38(4):221-5
15312577
Eur J Clin Nutr. 2005 Sep;59(9):1022-9
15970940
PLoS Med. 2006 Mar;3(3):e47
16417408
Wei Sheng Yan Jiu. 2006 Nov;35(6):768-71
17290763
Beijing Da Xue Xue Bao Yi Xue Ban. 2007 Apr 18;39(2):126-31
17440584
Am J Hum Biol. 2007 Sep-Oct;19(5):662-8
17636531
Am J Hum Biol. 2007 Nov-Dec;19(6):789-800
17691098
Lancet. 2008 Jan 26;371(9609):340-57
18206223
Lancet. 2008 Jan 19;371(9608):243-60
18207566
Haematologica. 2008 Jul;93(7):1068-71
18508787
Coll Antropol. 2008 Sep;32(3):807-12
18982755
BMJ. 2008 Nov 07;337:a2001
18996930
Zhonghua Er Ke Za Zhi. 2009 May;47(5):371-5
19573410
Dev Cell. 2009 Dec;17(6):755-73
20059947
Am J Phys Anthropol. 1977 Nov;47(3):473-82
201173
J R Soc Med. 1991 May;84(5):257-60
2041000
Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11459-64
20534544
Am J Clin Nutr. 2010 Sep;92(3):594-602
20592134
Zhonghua Yu Fang Yi Xue Za Zhi. 2012 Oct;46(10):932-6
23363870
J Child Health Care. 2014 Dec;18(4):358-68
23908371
Int J Obes (Lond). 2015 Apr;39(4):586-92
25435256
Am J Hum Biol. 1990;2(6):627-637
28520138
J Chronic Dis. 1970 Aug;23(2):93-103
5455357
Am J Phys Anthropol. 1982 Nov;59(3):251-62
7158661
Int J Epidemiol. 1998 Apr;27(2):242-7
9602405