Microbiome and food allergy.
Food allergy is a common disease affecting approximately 8% of children and 5% of adults. The prevalence has increased over the last two decades, suggesting an important environmental contribution to susceptibility. Studies have identified mode of birth, pet exposure, and having older siblings as being significant risk modifying factors in the development of food allergy. With the discovery that these factors significantly impact the composition of the intestinal microbiome, which is known to play a critical role in shaping the immune system, recent studies have begun to address the role of the intestinal microbiota in the development of food allergy. Studies in human cohorts support a dysbiosis in food allergy, and limited data suggest that this dysbiosis occurs early in life, preceding the onset of sensitization. Studies from animal models have clearly shown that the composition of the intestinal microbiota confers susceptibility to food allergy, and that there are organisms such as Clostridia species that are protective in the development of food allergy. Our understanding of microbial regulation of food allergy is in its nascency, but the state of the field supports an important contribution of intestinal microbes to susceptibility. Challenges going forward are to identify commensal-derived microorganisms that could be used therapeutically to prevent or perhaps treat food allergy.
Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
Ana B
AB
Blázquez
Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address: cecilia.berin@mssm.edu.
M Cecilia
MC
Berin
D000818:Animals; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D005512:Food Hypersensitivity / Q000453:epidemiology / Q000382:microbiology*; D000069196:Gastrointestinal Microbiome; D041981:Gastrointestinal Tract / Q000382:microbiology; D006801:Humans; D064307:Microbiota
Gut Microbes. 2015;6(5):321-5
26516657
Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12204-9
20566854
Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11971-5
20566857
Cell Rep. 2016 Jun 21;15(12):2809-24
27332875
Science. 2015 Aug 28;349(6251):989-93
26160380
EBioMedicine. 2015 Nov 27;3:172-9
26870828
Ann N Y Acad Sci. 2015 Nov;1356:1-21
25930993
BMC Microbiol. 2015 Aug 01;15:154
26231752
J Allergy Clin Immunol. 2013 Jan;131(1):201-12
23201093
J Allergy Clin Immunol. 2012 Feb;129(2):434-40, 440.e1-2
22153774
Nature. 2012 May 09;486(7402):222-7
22699611
J Immunol. 2004 Jun 1;172(11):6978-87
15153518
Gastroenterology. 2011 May;140(6):1713-9
21530737
J Allergy Clin Immunol. 2016 Oct;138(4):1122-1130
27292825
Pediatr Allergy Immunol. 2013 Jun;24(4):311-320.e8
23578298
Science. 2011 Jan 21;331(6015):337-41
21205640
Science. 2013 Aug 2;341(6145):569-73
23828891
Immunol Allergy Clin North Am. 2015 Feb;35(1):45-59
25459576
Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12522-7
25114261
J Allergy Clin Immunol. 2011 Mar;127(3):668-76.e1-2
21377036
N Engl J Med. 2015 Feb 26;372(9):803-13
25705822
Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13145-50
25157157
Front Cell Infect Microbiol. 2015 Feb 05;5:3
25705611
Sci Transl Med. 2014 Jan 22;6(220):220ra11
24452263
Nature. 2013 Aug 8;500(7461):232-6
23842501
J Allergy Clin Immunol. 2014 Feb;133(2):291-307; quiz 308
24388012
Nat Med. 2012 Mar 25;18(4):538-46
22447074
FEMS Microbiol Ecol. 2012 Jan;79(1):192-202
22029421
J Allergy Clin Immunol. 2008 Jan;121(1):129-34
18028995
J Allergy Clin Immunol. 2011 Mar;127(3):795-805.e1-6
21167580
MBio. 2015 Feb 03;6(1):null
25650398
Appl Environ Microbiol. 2014 Apr;80(8):2546-54
24532064
Allergy Asthma Clin Immunol. 2013 Apr 22;9(1):15
23607879
Cell Host Microbe. 2015 May 13;17(5):690-703
25974306
Mucosal Immunol. 2013 Jan;6(1):114-21
22718261
Clin Exp Allergy. 2015 Mar;45(3):632-43
25599982
J Allergy Clin Immunol. 2013 Aug;132(2):387-92.e1
23810152
Cell Host Microbe. 2013 Nov 13;14(5):559-70
24237701