Resistance to β-Lactams in Neisseria ssp Due to Chromosomally Encoded Penicillin-Binding Proteins.
Neisseria meningitidisandNeisseria gonorrhoeaeare human pathogens that cause a variety of life-threatening systemic and local infections, such as meningitis or gonorrhoea. The treatment of such infection is becoming more difficult due to antibiotic resistance. The focus of this review is on the mechanism of reduced susceptibility to penicillin and other β-lactams due to the modification of chromosomally encoded penicillin-binding proteins (PBP), in particular PBP2 encoded by thepenAgene. The variety ofpenAalleles and resulting variant PBP2 enzymes is described and the important amino acid substitutions are presented and discussed in a structural context.
Institut de Biologie Structurale (IBS), University Grenoble Alpes, CEA, CNRS, Grenoble 38044, France. andre.zapun@ibs.fr.
André
A
Zapun
Institut de Biologie Structurale (IBS), University Grenoble Alpes, CEA, CNRS, Grenoble 38044, France. cecile.morlot@ibs.fr.
Cécile
C
Morlot
Invasive Bacterial Infection and National Reference Center for Meningococci, Institut Pasteur, Paris 75015, France. muhamed-kheir.taha@pasteur.fr.
Muhamed-Kheir
MK
Taha
Neisseria gonorrhoeae; Neisseria meningitidis; penicillin-binding proteins; β-lactam resistance
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