Cytotoxic new furoquinoline alkaloid isolated from Ammi majus L. growing in Egypt.
Two alkaloids of the furoquinoline-type were isolated from Ammi majus L.; a new one and was identified as 4-hydro-7-hydroxy-8-methoxyfuroquinoline (1), and the other was isolated for the second time from nature and was identified as 4-hydro-7-hydroxy-8-prenyloxyfuroquinoline (2). The structures of the isolated compounds were established and confirmed by 1D and 2D NMR spectroscopy including1H,13C NMR, COSY, HSQC and HMBC, while the exact masses were confirmed by HRESI/MS. The cytotoxic activity of the isolated compounds (1 and 2) was evaluated against HepG-2, PC-3, A-549 and MCF-7 and the obtained results suggested selective antiproliferative and cytotoxic effects, with IC50= 230.2 and 326.5 μM against HepG-2 and MCF-7, respectively, for compound (1). While, compound (2) recorded IC50= 234.2 μM against MCF-7.
a Nucleic Acid Center, Institute of Physics, Chemistry and Pharmacy , University of Southern Denmark , Odense , Denmark.|b Pharmaceutical and Drug Industries Research Division, Pharmacognosy Department , National Research Centre , Cairo , Egypt.
Magdy M D
MM
Mohammed
c Ecology Department , Desert Research Center , Mathef El-Mataria , Egypt.|d Science Faculty for Girls, Department of Chemistry , Northern Border University-Arar , Arar , Saudi Arabia.
Eman R
ER
El-Sharkawy
D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D031165:Ammi / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004534:Egypt; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010936:Plant Extracts / Q000737:chemistry; D011804:Quinolines / Q000302:isolation & purification / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013329:Structure-Activity Relationship
D000470:Alkaloids; D010936:Plant Extracts; D011804:Quinolines
Ammi majus L.; SAR; Umbelliferae; cytotoxicity; furoquinoline alkaloids