Antidiabetic activity of Chandraprabha vati - A classical Ayurvedic formulation.
BACKGROUND
Chandraprabha vati is a classical Ayurvedic formulation, markedly used for mitigation of Prameha, which correlates in many ways with obesity, metabolic syndrome and diabetes mellitus.


OBJECTIVE
The present study was aimed to investigate effect of Chandraprabha vati in experimentally-induced hyperglycemia and lipid profile alterations.


METHODS
Antidiabetic effect of Chandraprabha vati was studied in fifty five Wistar rats. Graded doses of Chandraprabha vati (50, 100 and 200 mg/kg) were administered orally for 7 days to normal and alloxan-hyperglycemic rats (65 mg/kg, intravenously), and to glucose loaded normal rats for oral glucose tolerance test (OGTT). Fasting plasma glucose levels were assessed on different time intervals along with plasma cholesterol and triglycerides. Metformin (500 mg/kg, orally) was used as standard drug.


RESULTS
Chandraprabha vati did not cause any significant reduction in plasma glucose levels of normal rats (p > 0.05) but normalized the impaired glucose tolerance at 60 and 120 min (p < 0.05-p < 0.001) in OGTT when compared to vehicle control. In alloxan-hyperglycemic rats, administration of Chandraprabha vati (200 mg/kg) significantly reduced plasma glucose at 3 h, 12 h, 3rd day and 7th day (p < 0.01-p < 0.001) along with reduction in cholesterol and triglycerides levels (p < 0.01-p < 0.001) when compared to diabetic control group. The effects were comparable with metformin.


CONCLUSIONS
Chandraprabha vati exhibited anti-hyperglycemic effect and attenuated alterations in lipid profile. The results support the use of Chandraprabha vati for correction of Prameha in clinical practice.
National Research Institute for Ayurveda-Siddha Human Resource Development, Gwalior, 474009, Madhya Pradesh, India. Electronic address: manish.nriashrd@gmail.com.
Manish M
MM
Wanjari
School of Studies in Biochemistry, Jiwaji University, Gwalior, 474011, Madhya Pradesh, India.
Sujata
S
Mishra
National Research Institute for Ayurveda-Siddha Human Resource Development, Gwalior, 474009, Madhya Pradesh, India.
Yadu Nandan
YN
Dey
National Research Institute for Ayurveda-Siddha Human Resource Development, Gwalior, 474009, Madhya Pradesh, India.
Deepti
D
Sharma
Central Council for Research in Ayurvedic Sciences, New Delhi, 110058, India.
Sudesh N
SN
Gaidhani
National Research Institute for Ayurveda-Siddha Human Resource Development, Gwalior, 474009, Madhya Pradesh, India.
Ankush D
AD
Jadhav
Anti-hyperglycemic; Glucose tolerance test; Lipid profile; Metformin; Prameha
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