Rh(II)-Catalyzed Transannulation of N-Sulfonyl-1,2,3-Triazoles with 2,1-Benzisoxazoles or 1,2-Benzisoxazoles.
A Rh(II)-catalyzed transannulation of N-sulfonyl-1,2,3-triazoles with 2,1-benzisoxazoles has been developed, which affords an efficient method for the synthesis of quinazoline derivatives. The transformation represents an unprecedented example which utilizes N-sulfonyl-1,2,3-triazole as an aza-[2C]-component in cycloadditions. Meanwhile, a Rh(II)-catalyzed formal [3 + 2] cycloaddition of N-sulfonyl-1,2,3-triazoles with 1,2-benzisoxazoles is also presented, which enables the rapid synthesis of functionalized imidazole derivatives.
School of Pharmaceutical Sciences, Tsinghua University , Beijing 100084, China.
Xiaoqiang
X
Lei
School of Pharmaceutical Sciences, Tsinghua University , Beijing 100084, China.
Mohan
M
Gao
School of Pharmaceutical Sciences, Tsinghua University , Beijing 100084, China.|Collaborative Innovation Center for Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Medical School, Sichuan University , Chengdu 610041, China.|Beijing National Laboratory for Molecular Sciences (BNLMS) , Beijing 100190, China.
Yefeng
Y
Tang