The microbial epigenome in metabolic syndrome.
Dietary habits, lifestyle, medication, and food additives affect the composition and functions of the GI microbiota. Metabolic syndrome is already known to be associated with an aberrant gut microbiota affecting systemic low-grade inflammation, which is also outlined by differing epigenetic patterns. Thus, structural changes and compositional evaluation of gut microbial differences affecting epigenetic patterns in metabolic syndrome are of research interest. In the present review we focus on the disparities in the gut microbiota composition of metabolic syndrome and the resulting aberrant profile of bioactive microbial metabolites known to affect epigenetic modifications such as G-protein coupled receptors and inflammatory pathways.
Department of Nutritional Sciences, University Vienna, Vienna, Austria. Electronic address: marlene.remely@univie.ac.at.
Marlene
M
Remely
Department of Nutritional Sciences, University Vienna, Vienna, Austria.
Alexander G
AG
Haslberger
D000818:Animals; D044127:Epigenesis, Genetic; D000069196:Gastrointestinal Microbiome / Q000235:genetics*; D006801:Humans; D024821:Metabolic Syndrome / Q000235:genetics* / Q000382:microbiology*; D055442:Metabolome; D008954:Models, Biological; D051193:Toll-Like Receptors / Q000378:metabolism
D051193:Toll-Like Receptors
DNA methylation; Firmicutes/Bacteroidetes ratio; Obesity; SCFAs