Plasma endocan level and prognosis of immunoglobulin A nephropathy.
BACKGROUND
Endocan, previously called endothelial cell-specific molecule-1, is a soluble proteoglycan that is secreted from vascular endothelial cells. Elevated plasma endocan levels were shown to be associated with poor cardiovascular outcomes in patients with chronic kidney disease (CKD). We investigated the clinical relevance of plasma and urine endocan levels in patients with immunoglobulin A nephropathy (IgAN).


METHODS
Sixty-four patients with IgAN and 20 healthy controls were enrolled in this study. Plasma and urine endocan levels were measured. Clinical parameters, pathologic grades, and renal outcomes were compared among subgroups with different plasma and urine endocan levels.


RESULTS
Both plasma and urine endocan levels were significantly higher in patients with IgAN than in controls. Elevated serum phosphorus and C-reactive protein were independent determinants for plasma endocan, and elevated C-reactive protein was also an independent determinant for urine endocan levels in multivariate analysis. Plasma endocan level was not significantly different across CKD stages, but patients with higher plasma endocan levels showed adverse renal outcome. Urine endocan levels were also elevated in patients with poor renal function. Cox proportional hazard models showed that high plasma endocan was an independent risk factor for CKD progression after adjusting for the well-known predictors of outcome in patients with IgAN.


CONCLUSIONS
This study suggested that plasma endocan might be useful as a prognostic factor in patients with IgAN.
Division of Nephrology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
Yu Ho
YH
Lee
Division of Nephrology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
Jin Sug
JS
Kim
Division of Nephrology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
Se-Yun
SY
Kim
Division of Nephrology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
Yang Gyun
YG
Kim
Division of Nephrology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
Ju-Young
JY
Moon
Division of Nephrology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
Kyung-Hwan
KH
Jeong
Division of Nephrology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
Tae Won
TW
Lee
Division of Nephrology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
Chun-Gyoo
CG
Ihm
Division of Nephrology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
Sang-Ho
SH
Lee
Endocan; Endothelial cell–specific molecule-1; Immunoglobulin A nephropathy
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