Common Substances That May Contribute to Resistant Hypertension, and Recommendations for Limiting Their Clinical Effects.
The purpose of this review is to highlight common or important substances or habits that elevate blood pressure and offer suggestions, based on recent literature, to limit their use or effects.



Despite decades of advice to the general populace from public health authorities to avoid or reduce dietary sodium and non-steroidal anti-inflammatory drug (NSAID) use, more evidence has accumulated from nationwide surveys, clinical trials, and pathophysiological or mechanistic studies that show how important these modalities can (and should) be for hypertensive and prehypertensive individuals and the general population. Other common stimuli that increase blood pressure can be divided into many that are easily avoided (e.g., phenethylamines, anabolic steroids), those that must be continued for important medical reasons (e.g., erythropoietin, tyrosine kinase inhibitors) and therefore require intensified antihypertensive therapy, and a few (e.g., glucocorticoids, hormonal contraceptives) that fall between these two paradigms.
Division of Pharmacology, Department of Biomedical Sciences, College of Osteopathic Medicine, Pacific Northwest University of Health Sciences, 200 South University Parkway, Yakima, WA, 98901, USA.
Samuel J
SJ
Jurca
Division of Pharmacology, Department of Biomedical Sciences, College of Osteopathic Medicine, Pacific Northwest University of Health Sciences, 200 South University Parkway, Yakima, WA, 98901, USA. wj.elliott@yahoo.com.
William J
WJ
Elliott
D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D001795:Blood Pressure Determination; D006801:Humans; D006973:Hypertension / Q000139:chemically induced* / Q000188:drug therapy / Q000517:prevention & control
D000959:Antihypertensive Agents
Blood pressure; Drug-induced hypertension; Resistant hypertension; Secondary hypertension
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