Routine evaluation of left ventricular function using CZT-SPECT, with low injected activities and limited recording times.
OBJECTIVE
Gamma-cameras, with Cadmium-Zinc-Telluride (CZT) detectors, allow to perform myocardial perfusion imaging (MPI) with limited injected activities and recorded times. This study aimed at determining whether the routine assessment of left ventricular (LV) function with such limited counts protocols compares well with reference values from cardiac MRI.


METHODS
The study included patients who have undergone cardiac MRI and an MPI routinely planned on a CZT camera with a low-dose protocol (120 MBq of Sestamibi for stress and 360 MBq at rest for 75 kg body weight), while targeting the recording of only 500 myocardial kcounts in order to limit the recording times (<10 minutes for stress, <4 minutes for rest). SPECT images were reconstructed with a method maintaining rather high spatial (8 mm) and temporal (16 frames/cycle) resolutions.


RESULTS
Seventy-six patients were included, and mean effective dose was 3.5 ± 1.7 mSv for the total MPI protocol. Correlations between CZT-SPECT and MRI were good to excellent for ejection fraction (r2= 0.77), end-diastolic (r2= 0.88) and end-systolic (r2= 0.93) volumes, and the analysis of segmental contractility correlated well between the two techniques (kappa score = 0.72 ± 0.02).


CONCLUSIONS
LV function, assessed on a CZT camera with low injected activities and limited recording times, correlates well with the reference assessment from cardiac MRI.
Department of Nuclear Medicine, CHU-Nancy, Nancy, France.
Marine
M
Claudin
Department of Nuclear Medicine, CHU-Nancy, Nancy, France. l.imbert@chu-nancy.fr.|Nancyclotep Molecular Imaging Platform, Nancy, France. l.imbert@chu-nancy.fr.|UMR 7039 CRAN and Université de Lorraine, Nancy, France. l.imbert@chu-nancy.fr.
Laetitia
L
Imbert
Department of Nuclear Medicine, CHU-Nancy, Nancy, France.|INSERM U947 and Université de Lorraine, Nancy, France.
Wassila
W
Djaballah
Department of Nuclear Medicine, CHU-Nancy, Nancy, France.|Nancyclotep Molecular Imaging Platform, Nancy, France.
Nicolas
N
Veran
Nancyclotep Molecular Imaging Platform, Nancy, France.|INSERM U947 and Université de Lorraine, Nancy, France.
Sylvain
S
Poussier
Department of Nuclear Medicine, CHU-Nancy, Nancy, France.|Nancyclotep Molecular Imaging Platform, Nancy, France.
Véronique
V
Roch
Department of Nuclear Medicine, CHU-Nancy, Nancy, France.
Mathieu
M
Perrin
Department of Nuclear Medicine, CHU-Nancy, Nancy, France.|Nancyclotep Molecular Imaging Platform, Nancy, France.|INSERM U947 and Université de Lorraine, Nancy, France.
Antoine
A
Verger
Nancyclotep Molecular Imaging Platform, Nancy, France.
Henri
H
Boutley
Department of Nuclear Medicine, CHU-Nancy, Nancy, France.|Nancyclotep Molecular Imaging Platform, Nancy, France.|INSERM U947 and Université de Lorraine, Nancy, France.
Gilles
G
Karcher
Department of Nuclear Medicine, CHU-Nancy, Nancy, France.|Nancyclotep Molecular Imaging Platform, Nancy, France.|INSERM U1116 and Université de Lorraine, Nancy, France.
Pierre-Yves
PY
Marie
D000368:Aged; D001835:Body Weight; D002104:Cadmium; D005260:Female; D015902:Gamma Cameras; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging; D011829:Radiation Dosage; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D013599:Systole; D017256:Technetium Tc 99m Sestamibi; D013691:Tellurium; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon; D016277:Ventricular Function, Left; D015032:Zinc
C474490:CdZnTe; D019275:Radiopharmaceuticals; D002104:Cadmium; D017256:Technetium Tc 99m Sestamibi; D015032:Zinc; D013691:Tellurium
CZT camera; Myocardial perfusion imaging (MPI); Tc-99m Sestamibi; gated-SPECT; left ventricular function
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