Association of factor XIII Val34Leu polymorphism and coronary artery disease: A meta-analysis.
BACKGROUND
Factor XIII plays an important role in the stabilization of the linkage between fibrins and in the pathophysiology of coronary artery disease (CAD). The association between factor XIII Val34Leu polymorphism and CAD risk remains controversial.


METHODS
We conducted a meta-analysis of 36 studies involving 26,940 cases and 34,694 controls. Subgroup analyses were performed with division of data into disease (myocardial infarction [MI], CAD without MI), age, and sex.


RESULTS
Factor XIII Val34Leu polymorphism was significantly associated with ove all CAD risk (odds ratio [OR] = 1.09, 95% confidence interval [CI] = 1.03-1.06, p = 0.004) and MI risk (OR = 1.15, 95% CI 1.07-1.25, p = 0.0003), but not with CAD without MI risk (OR = 1.00, 95% CI 0.87-1.15, p = 0.96). In the subgroup analysis by age and sex, there was no association between Val34Leu polymorphism and CAD.


CONCLUSIONS
This meta-analysis found that factor XIII Val34Leu polymorphism was associated with CAD risk, especially MI, but not with CAD without MI. In addition, age and sex did not affect the relationship between factor XIII Val34Leu polymorphism and CAD risk.
Jae Hyun
JH
Jung
Gwan Gyu
GG
Song
Jae-Hoon
JH
Kim
Young Ho
YH
Seo
Korea University College of Medicine, Seoul, Korea Department of Internal Medicine, Division of Rheumatology, Korea University Ansan Hospital, Ansan-si, Gyeonggi-do, Korea. csjmd888@korea.ac.kr.
Sung Jae
SJ
Choi
D003324:Coronary Artery Disease / Q000097:blood / Q000235:genetics*; D004247:DNA / Q000235:genetics*; D005176:Factor XIII / Q000235:genetics* / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic
D004247:DNA; D005176:Factor XIII
coagulation; coronary artery disease; factor XIII A Val34Leu; meta-analysis; myocardial infarction