Synthesis and antioxidant activity of curcumin analogs.
Numerous biological activities including antioxidant, antitumor, anti-inflammation, and antivirus of the natural product curcumin were reported. However, the clinical application of it was significantly limited by its instability, poor solubility, less body absorbing, and low bioavailability. This review focuses on the structure modification and antioxidant activity evaluation of curcumin. To study the structure-activity relationship (SAR), five series of curcumin analogs were synthesized and their antioxidant activity were evaluated in vitro. The results showed that electron-donating groups, especially the phenolic hydroxyl group are an essential component to improve the antioxidant activity.
a Institute of Pharmacy & Pharmacology , University of South China , Hengyang 421001 , China.|b Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study , Hengyang 421001 , China.
Qu-Tong
QT
Zheng
a Institute of Pharmacy & Pharmacology , University of South China , Hengyang 421001 , China.|b Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study , Hengyang 421001 , China.
Ze-Hua
ZH
Yang
a Institute of Pharmacy & Pharmacology , University of South China , Hengyang 421001 , China.|b Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study , Hengyang 421001 , China.
Liu-Ying
LY
Yu
a Institute of Pharmacy & Pharmacology , University of South China , Hengyang 421001 , China.|b Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study , Hengyang 421001 , China.
Yu-Yan
YY
Ren
a Institute of Pharmacy & Pharmacology , University of South China , Hengyang 421001 , China.|b Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study , Hengyang 421001 , China.
Qiu-Xia
QX
Huang
a Institute of Pharmacy & Pharmacology , University of South China , Hengyang 421001 , China.|b Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study , Hengyang 421001 , China.|c Research Interest Group of Pharmacy , University of South China , Hengyang 421001 , China.
Qiu
Q
Liu
a Institute of Pharmacy & Pharmacology , University of South China , Hengyang 421001 , China.|b Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study , Hengyang 421001 , China.
Xiang-Yu
XY
Ma
a Institute of Pharmacy & Pharmacology , University of South China , Hengyang 421001 , China.|b Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study , Hengyang 421001 , China.|c Research Interest Group of Pharmacy , University of South China , Hengyang 421001 , China.
Zi-Kang
ZK
Chen
a Institute of Pharmacy & Pharmacology , University of South China , Hengyang 421001 , China.|b Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study , Hengyang 421001 , China.
Zong-Bao
ZB
Wang
a Institute of Pharmacy & Pharmacology , University of South China , Hengyang 421001 , China.|b Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study , Hengyang 421001 , China.
Xing
X
Zheng
D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D003474:Curcumin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D000975:Antioxidants; D003474:Curcumin
Curcumin; antioxidant activity; structure modification; structure–activity relationship