A Green Approach to the Synthesis of α-Amino Phosphonate in Water Medium: Carbene Insertion into the N-H Bond by Cu(I) Catalyst.
Synthesis of amino phosphonates is more important owing to their significant applications in the biological systems. There are few methods already known in the literature to make these molecules; however, known methods have their own disadvantages. In this regard, synthesis of different kinds of amino phosphonates have been achieved via phosphonate substituted carbene insertion into the N-H bond of aniline catalyzed by readily available copper salt under mild reaction conditions in water. In order to find an efficient catalyst for carbene insertion reaction in neat water, a large number of transition metal catalysts were screened, and we found that the [Cu(CH3CN)4]ClO4was the best catalyst under employed reaction conditions. Using this environmentally benign methodology (copper catalyzed reaction in water), a large number of biologically important amino phosphonates have been synthesized, isolated (37 examples), and characterized using standard analytical and spectroscopic techniques.
Catalysis and Energy Laboratory (A Central University), Department of Chemistry Pondicherry University , Puducherry 605014, India.
Kankanala
K
Ramakrishna
Catalysis and Energy Laboratory (A Central University), Department of Chemistry Pondicherry University , Puducherry 605014, India.
Jisha Mary
JM
Thomas
Catalysis and Energy Laboratory (A Central University), Department of Chemistry Pondicherry University , Puducherry 605014, India.
Chinnappan
C
Sivasankar