Turn up the lysosome.
Lysosomes are digestive organelles of the endocytic and autophagic pathways. Increasing lysosome enzyme activities could help to clear pathological cellular waste. A recent study shows that lysosomal digestive functions can be promoted in isolated cells and mice by pharmacologically stimulating the autophagy- and lysosome-regulating transcription factors TFEB and ZKSCAN3 through previously unrecognized mTORC1-independent pathways acting via PKC.
Biochemical Institute of the Christian-Albrechts University Kiel, Olshausenstrasse 40, D-24098 Kiel, Germany.
Paul
P
Saftig
Institute for Cell Biology of the Rheinische Friedrich-Wilhelms University Bonn, D-53121 Bonn, Germany.
Albert
A
Haas
D000818:Animals; D001343:Autophagy / Q000502:physiology*; D006801:Humans; D008247:Lysosomes / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000378:metabolism*; D053858:Metabolic Networks and Pathways / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism*
D026901:Membrane Transport Proteins; D014157:Transcription Factors
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