Resveratrol Supplementation and Oxidative/Anti-Oxidative Status in Patients with Ulcerative Colitis: A Randomized, Double-Blind, Placebo-controlled Pilot Study.
Oxidative stress is involved in both pathogenesis and exacerbation of ulcerative colitis (UC). This study was designed to evaluate whether resveratrol, an excellent anti-oxidant agent, can help in treatment of UC and its related oxidative stress.



Fifty six patients with active mild to moderate disease were randomized to receive either 500 mg/day resveratrol capsules or the same amount of placebo for 6 weeks. Before and after the intervention, disease activity, quality of life, and oxidative stress were assessed using the Simple Clinical Colitis Activity Index Questionnaire (SCCAIQ), Inflammatory Bowel Disease Questionnaire-9 (IBDQ-9), and serum level of malondialdehyde (MDA), superoxide dismutase (SOD), and total anti-oxidant capacity (TAC), respectively. Serum SOD (122.28 ± 11.55 to 125.77 ± 10.97) and TAC (9.87 ± 1.51-11.97 ± 1.61) increased, whereas serum MDA (5.62 ± 1.18-3.42 ± 1.01) decreased significantly in resveratrol group (p <0.001). Moreover, resveratrol supplementation significantly decreased disease activity and increased the quality of life (p <0.001).



Our data indicate that 500 mg/day resveratrol supplementation can improve the disease activity and quality of life in patients with UC at least partially through reduction of oxidative stress. Further studies are needed to determine the optimal dosage of supplementation for these patients.
Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology, Research Institute Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Maryam
M
Samsamikor
Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Naser Ebrahimi
NE
Daryani
Department of Biostatistics, Tehran University of Medical Sciences, Tehran, Iran.
Parisa Rezanejad
PR
Asl
Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology, Research Institute Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: a_hekmat2000@yahoo.com.
Azita
A
Hekmatdoost
D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage*; D003093:Colitis, Ulcerative / Q000097:blood* / Q000523:psychology; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D010865:Pilot Projects; D011446:Prospective Studies; D011788:Quality of Life; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage*; D013482:Superoxide Dismutase / Q000097:blood; D011795:Surveys and Questionnaires
D000975:Antioxidants; D013267:Stilbenes; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D000077185:Resveratrol
Inflammatory bowel disease; Oxidative stress; Resveratrol; Ulcerative colitis