Subfoveal choroidal thickness as a predictor of central serous chorioretinopathy.
PurposeThe purpose of the study was to evaluate the role of subfoveal choroidal thickness (CT) measurements as a predictor for the course of central serous chorioretinopathy (CSC).Patients and methodsThirty-eight eyes of 33 patients with CSC were analyzed retrospectively. Key inclusion criteria were naive (acute or recurrent) CSC; a minimum of 12 months of follow up; and the availability of good quality enhanced depth imaging SD-OCT images at each visit. Eyes with changes suggestive of chronic CSC and history of any treatment were excluded. Collected data included demographic profile, visual acuity, subfoveal CT, central macular thickness (CMT), and treatment details. Univariate and multivariate analyses for association of baseline features with need for treatment were performed. On the basis of results of this analysis, the 38 eyes were divided into two groups: Group A (subfoveal CT≤356 μm) and Group B (subfoveal CT>356 μm).ResultsOn univariate analysis, the need for treatment had significantly positive correlation with duration of symptoms (P=0.02), negative correlation with the baseline CT (P<0.01), and no significant correlation with CMT (P=0.13). On multivariate regression analysis, only baseline CT had a statistically significant association with the need for treatment (odds ratio (OR), 0.989; CI, 0.979-0.999; P=0.048). Group A eyes were more likely to require treatment (Group A: 54.55%, 12 of 22 eyes; Group B: 18.75%, 3 of 16 eyes; OR: 5.2, 95% CI, 1.15-23.54; P=0.04). There was a significant decrease in subfoveal CT in Group B (-105.62±108.91 μm; P=0.002).ConclusionCSC with a subfoveal CT≤356 μm is of chronic nature and is more likely to require treatment rather than observation.
Srimati Kanuri Santhamma Centre for Vitreo-Retinal Diseases, Hyderabad Eye Research Foundation, LV Prasad Eye Institute, Hyderabad, India.
V
V
Ambiya
Srimati Kanuri Santhamma Centre for Vitreo-Retinal Diseases, Hyderabad Eye Research Foundation, LV Prasad Eye Institute, Hyderabad, India.
R
R
Yogi
Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA.
A
A
Li
Banker's Retina Clinic & Laser Centre, Ahmedabad, India.
S
S
Shah
Banker's Retina Clinic & Laser Centre, Ahmedabad, India.
C
C
Sarvaiya
Retina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
P
P
Mehta
Retina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
C
C
Meyerele
Apdo 144-1225 Plaza Mayor, San José, Costa Rica.
L
L
Wu
Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA.
R
R
Singh
Banker's Retina Clinic & Laser Centre, Ahmedabad, India.
A
A
Banker
Srimati Kanuri Santhamma Centre for Vitreo-Retinal Diseases, Hyderabad Eye Research Foundation, LV Prasad Eye Institute, Hyderabad, India.
J
http://orcid.org/0000-0003-1772-3558
J
Chhablani
D000328:Adult; D000368:Aged; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis* / Q000473:pathology; D002829:Choroid / Q000473:pathology*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012044:Regression Analysis; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity; D055815:Young Adult
D007208:Indocyanine Green
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