The Expanding Role of Natural Killer Cells in Type 1 Diabetes and Immunotherapy.
Treatments for autoimmune diseases including type 1 diabetes (T1D) are aimed at resetting the immune system, especially its adaptive arm. The innate immune system is often ignored in the design of novel immune-based therapies. There is increasing evidence for multiple natural killer (NK) subpopulations, but their role is poorly understood in autoimmunity and likely is contributing to the controversial role reported for NKs. In this review, we will summarize NK subsets and their roles in tolerance, autoimmune diabetes, and immunotherapy.
Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.
Chris
C
Fraker
Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL, 33136, USA. abayer@med.miami.edu.|Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA. abayer@med.miami.edu.
Allison L
AL
Bayer
D056704:Adaptive Immunity; D000818:Animals; D015551:Autoimmunity / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007108:Immune Tolerance; D007113:Immunity, Innate; D007167:Immunotherapy; D007694:Killer Cells, Natural / Q000276:immunology*
Diabetes; Natural killer cells; Tolerance
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