S100A8/A9 in psoriatic plaques from patients with psoriatic arthritis.
OBJECTIVE
To evaluate levels of the calcium-binding proteins S100A8 and S100A9 in the skin of patients with psoriatic arthritis.


METHODS
Skin punch biopsies were obtained from patients with psoriatic arthritis and healthy control subjects. S100A8/A9 were semiquantified via immunohistochemistry and semiquantitative polymerase chain reaction.


RESULTS
The study included biopsies from nine patients with psoriatic arthritis and nine control subjects. S100A8 and S100A9 were present at visibly higher levels in psoriatic plaques compared with normal skin samples. S100A8 and S100A9 RNA levels were significantly higher in the peripheral region of plaques compared with the central region.


CONCLUSIONS
Both S100A8 and S100A9 may represent good therapeutic targets in psoriasis and psoriatic arthritis.
Rheumatology, Allergology and Clinical Immunology, Department of Systemic Medicine, University of Rome "Tor Vergata", Rome, Italy maria.sole.chimenti@uniroma2.it.
Maria Sole
MS
Chimenti
Rheumatology, Allergology and Clinical Immunology, Department of Systemic Medicine, University of Rome "Tor Vergata", Rome, Italy.
Paola
P
Triggianese
Dermatology, Department of Neurosciences, Mental Health and Sensory (NESMOS), University of Rome "La Sapienza", Rome, Italy.
Elisabetta
E
Botti
Dermatology, Department of Neurosciences, Mental Health and Sensory (NESMOS), University of Rome "La Sapienza", Rome, Italy.
Alessandra
A
Narcisi
Rheumatology, Allergology and Clinical Immunology, Department of Systemic Medicine, University of Rome "Tor Vergata", Rome, Italy.
Paola
P
Conigliaro
Dermatology, Department of Systemic Medicine, University of Rome "Tor Vergata", Rome, Italy.
Alessandro
A
Giunta
Dermatology, Department of Systemic Medicine, University of Rome "Tor Vergata", Rome, Italy.
Miriam
M
Teoli
Rheumatology, Allergology and Clinical Immunology, Department of Systemic Medicine, University of Rome "Tor Vergata", Rome, Italy.
Roberto
R
Perricone
Dermatology, Department of Neurosciences, Mental Health and Sensory (NESMOS), University of Rome "La Sapienza", Rome, Italy.
Antonio
A
Costanzo
Inflammation; S100A8; S100A9; psoriatic arthritis; psoriatic plaques; skin lesions
J Immunol. 2003 Sep 1;171(5):2602-9
12928412
Nature. 2005 Sep 15;437(7057):369-75
16163348
Immunity. 2013 Dec 12;39(6):1171-81
24332034
Mol Med. 2005 Jan-Dec;11(1-12):21-9
16622521
Autoimmun Rev. 2013 Mar;12(5):599-606
23183378
Dermatologica. 1978;157(4):238-44
357213
Arthritis Rheum. 1993 Jul;36(7):893-900
7686370
Trends Immunol. 2003 Apr;24(4):155-8
12697438
Exp Dermatol. 2015 Jul;24(7):522-8
25828150