[Application of benchmark dose on renal injury in people chronically exposed to lead].
Objective:To screen sensitive indicators of renal injury in lead workers using benchmark dose method.Methods:Of the 486 subjects,116 did not occupationally contact to lead as a control. The blood lead was considered as exposure biomarker, while Uβ2-MG and UNAG as effect biomarkers for renal injury. The BMD and BMDL of blood lead were estimated at the 10% benchmark response using BMDS Version 2.6.Results:There was statistical rise in blood lead between the lead group and control group (P<0.05) ; and the blood lead level was divided into four groups by quarterback spacing method, among which UNAG was statistically different (P<0.05) . There was an increased prevalence of abnormal rates of Uβ2-MG and UNAG with increasing blood lead concentration (P<0.05) , after trend chi-square test. BMD and BMDL of UNAG and Uβ2-MG were 602.784/431.838 μg/L and 130.398/100.981 μg/L caculated by Log-Probit model, respectively.Conclusions:Occupational lead exposure may cause kidney damage, and UNAG could be as a more sensitive marker for monitoring early renal injury than Uβ2-MG.
Department of Epidemiology and Statistics, Hebei Medical University, Shijiazhuang 050017, China.
Q Y
QY
Dong
C X
CX
Zhao
H
H
Zheng
F Z
FZ
Chen
Z M
ZM
Li
Y H
YH
Li
H X
HX
Ji
H Y
HY
Hao
W
W
Zhao
J Q
JQ
Gao
H T
HT
Liu
J
J
He
X N
XN
Zhang
J G
JG
Li
J X
JX
Yuan
D000328:Adult; D019985:Benchmarking; D015415:Biomarkers / Q000032:analysis; D006801:Humans; D007668:Kidney; D007674:Kidney Diseases / Q000139:chemically induced*; D007854:Lead / Q000097:blood / Q000633:toxicity*; D009784:Occupational Diseases / Q000139:chemically induced*; D016273:Occupational Exposure / Q000009:adverse effects*; D015995:Prevalence; D001613:beta 2-Microglobulin
D015415:Biomarkers; D001613:beta 2-Microglobulin; D007854:Lead