The Significance of Long Noncoding RNA H19 in Predicting Progression and Metastasis of Cancers: A Meta-Analysis.
Recently, numerous studies indicate that H19 plays a key role in tumorigenesis, but the results have been disputed, especially in the aspects of tumor progression and metastasis. Therefore, we performed this meta-analysis to systematically summarize the relationship between H19 and cancers. We searched PubMed, the Cochrane Library, CNKI, and Chinese Wan Fang to identify eligible studies. Odds ratios and 95% confidence intervals were calculated to assess the effect size. A total of 13 studies were enrolled in this meta-analysis, which was performed by Revman5.3 and Stata11.0 software. Our meta-analysis showed that the expression of H19 was associated with distant metastasis in nongastrointestinal tumors (OR = 3.85, 95% CI = 1.31-11.36,P= 0.01) and, in gastrointestinal tumors (OR = 0.34, 95% CI = 0.15-0.78,P= 0.01), lymph node metastasis (OR = 2.04, 95% CI = 1.19-3.48,P= 0.009). Moreover, in gastric cancer, H19 expression was significantly related to histological grade (OR = 0.50, 95% CI = 0.29-0.86,P= 0.01), TNM stage (OR = 0.19, 95% CI = 0.11-0.33,P< 0.01), and tumor invasion depth (OR = 0.11, 95% CI = 0.04-0.27,P< 0.01). Therefore, H19 could serve as a potential marker for progression and metastasis evaluation of cancers.
Department of Laboratory Medicine, Clinical Laboratory Medicine and Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Wei
0000-0002-5059-8982
W
Jing
Department of Laboratory Medicine, Clinical Laboratory Medicine and Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Man
0000-0003-3262-5817
M
Zhu
Department of Laboratory Medicine, Clinical Laboratory Medicine and Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Xian-Wei
0000-0002-9906-2054
XW
Zhang
Department of Laboratory Medicine, Clinical Laboratory Medicine and Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Zhong-Ya
0000-0001-7985-5711
ZY
Pan
Department of Laboratory Medicine, Clinical Laboratory Medicine and Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Shan-Shan
SS
Gao
Department of Laboratory Medicine, Clinical Laboratory Medicine and Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Hu
0000-0002-2092-680X
H
Zhou
Department of Laboratory Medicine, Clinical Laboratory Medicine and Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Shi-Li
0000-0002-8133-9676
SL
Qiu
Department of Laboratory Medicine, Clinical Laboratory Medicine and Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Chun-Zi
0000-0002-1055-1725
CZ
Liang
Department of Laboratory Medicine, Clinical Laboratory Medicine and Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, China; School of Laboratory Medicine, Hubei University of Traditional Chinese Medicine, Wuhan 430071, China.
Jian-Cheng
0000-0003-4304-1593
JC
Tu
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