How the codfish changed its immune system.
A common ancestor of the modern codfish acquired a set of mutations that eliminated a major arm of the adaptive immune system-the MHC II pathway of antigen presentation to CD4(+) T cells. Subsequent to this event, there was a radiation of these fish in which the number and diversity of MHC I genes increased in species-specific ways.
Department of Structural Biology, Stanford University, Stanford, California, USA.
Peter
P
Parham
D056704:Adaptive Immunity / Q000235:genetics*; D000818:Animals; D017951:Antigen Presentation / Q000235:genetics / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D048389:Gadus morhua / Q000235:genetics* / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D009154:Mutation; D013045:Species Specificity
D000949:Histocompatibility Antigens Class II
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