Anti-Inflammatory Activity of Citrus bergamia Derivatives: Where Do We Stand?
Inflammatory diseases affect a large portion of the worldwide population, and chronic inflammation is a major risk factor for several dangerous pathologies. To limit the side effects of both synthetic and biological anti-inflammatory drugs, the use of herbal medicines, nutraceuticals and food supplements has increased tremendously as alternative and/or complementary medicine to treat several pathologies, including inflammation. During the last decades, the biological properties of Citrus bergamia (bergamot) derivatives have obtained important scientific achievements, and it has been suggested their use in a context of a multitarget pharmacological strategy. Here, we present an overview of the anti-inflammatory properties of bergamot extracts that could represent the scientific basis for develop novel and alternative strategies to improve health status and attenuate inflammatory conditions.
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina I-98168, Italy. nadiaferlazzo@email.it.
Nadia
N
Ferlazzo
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina I-98168, Italy. scirmi@unime.it.
Santa
S
Cirmi
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina I-98125, Italy. gcalapai@unime.it.
Gioacchino
G
Calapai
Department of Biotechnology and Legal Medicine, University of Palermo, Palermo I-90127, Italy. elvira.ventura@unipa.it.
Elvira
E
Ventura-Spagnolo
Department of Clinical and Experimental Medicine, University of Messina, Messina I-98125, Italy. gangemis@unime.it.|Institute of Applied Sciences and Intelligent Systems (ISASI), National Research Council (CNR), Pozzuoli I-80078, Italy. gangemis@unime.it.
Sebastiano
S
Gangemi
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina I-98168, Italy. mnavarra@unime.it.
Michele
M
Navarra
D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000627:therapeutic use*; D002957:Citrus / Q000737:chemistry*; D029001:Herbal Medicine; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000473:pathology; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts
Citrus bergamia; antioxidant activity; bergamot; complementary and alternative medicines; flavonoids; inflammation; natural products
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