The Effectiveness and Safety of Thermocoagulation Radiofrequency Treatment of the Ophthalmic Division (V1) and/or Maxillary (V2) and Mandibular (V3) Division in Idiopathic Trigeminal Neuralgia: An Observational Study.
Trigeminal neuralgia (TN) is a pain appearing in the ophthalmic (V1), maxillary (V2), and mandibular (V3) trigeminal branches. Pharmacologic treatment is the first line for TN; however, many patients prefer to receive minimally invasive treatment rather than medicine because of intolerable side effects. Thermocoagulation radiofrequency (TRF) is a minimally invasive treatment that has been shown to effectively treat the maxillary (V2) and mandibular (V3) divisions, but the safety of TRF treatment of the ophthalmic (V1) division has been controversial.



This study was to observe the effectiveness and safety of TRF treatment of the ophthalmic (V1) division of trigeminal branches in idiopathic TN patients.



An observational study.



All of patients received temperature controlled TRF, the effectiveness and safety of TRF was assessed by VAS and complications.



Eighty patients with ophthalmic division (V1) or ophthalmic division (V1) combined with maxillary (V2) or mandibular (V3) divisions of idiopathic TN were treated with step-increased temperature TRF for 6 minutes. At a pulse width of 20 ms, the temperature was titrated up 2 degrees from 60 degrees to 66 degrees every 60 seconds, and then another 66 degrees or 68 degrees for 2 minutes. Meanwhile, the tip of the cannula was turned 180 degrees with each temperature titration. Patients were assessed for pain relief and corneal reflex, numbness, and masticatory muscle weakness at one week, one month, and 3 months after the procedure.



Eighty patients were successfully treated with temperature controlled TRF for ophthalmic (V1) division. Excellent pain relief was achieved in 79 of 80 patients (98.75%) after one week, one month, and 3 months, and 78 of 80 patients (97.5%) patients experienced tolerable numbness. Only one patient lost the corneal reflex, 14 experienced a corneal reflex that was mildly decreased, and 2 patients felt a foreign body sensation in the ipsilateral eye after TRF, but there were no corneal ulcers, incidences of blindness, or other complications.



This study is limited by being an observation study and a non-prospective trial with a short-term follow-up period.



Temperature controlled TRF to the ophthalmic division (V1) of the semilular ganglion is effectiveness and safe in TN.



Thermocoagulation radiofrequency, pulsed radiofrequency, trigeminal neuralgia, ophthalmic division, trigeminal ganglion, pain, numbness, corneal reflex.
Department of Pain Management, The State Key Clinical Specialty for Pain Medicine, The Second Affiliated hospital, Guangzhou Medical University, Guangzhou, Guangdong, P.R. China.
QiaoDong
Q
Huang
Department of Pain Management, The State Key Clinical Specialty for Pain Medicine, The Second Affiliated hospital, Guangzhou Medical University, Guangzhou, Guangdong, P.R. China.
XiaoMing
X
Liu
Department of Pain Management, The State Key Clinical Specialty for Pain Medicine, The Second Affiliated hospital, Guangzhou Medical University, Guangzhou, Guangdong, P.R. China.
JinSheng
J
Chen
Department of Pain Management, The State Key Clinical Specialty for Pain Medicine, The Second Affiliated hospital, Guangzhou Medical University, Guangzhou, Guangdong, P.R. China.
CunJu
C
Bao
Department of Pain Management, The State Key Clinical Specialty for Pain Medicine, The Second Affiliated hospital, Guangzhou Medical University, Guangzhou, Guangdong, P.R. China.
DongYang
D
Liu
Department of Pain Management, The State Key Clinical Specialty for Pain Medicine, The Second Affiliated hospital, Guangzhou Medical University, Guangzhou, Guangdong, P.R. China.
ZeZang
Z
Fang
Department of Pain Management, The State Key Clinical Specialty for Pain Medicine, The Second Affiliated hospital, Guangzhou Medical University, Guangzhou, Guangdong, P.R. China.
XiaoYu
X
Liang
Department of Pain Management, The State Key Clinical Specialty for Pain Medicine, The Second Affiliated hospital, Guangzhou Medical University, Guangzhou, Guangdong, P.R. China.
ZhenHe
Z
Lu
Department of Pain Management, The State Key Clinical Specialty for Pain Medicine, The Second Affiliated hospital, Guangzhou Medical University, Guangzhou, Guangdong, P.R. China.
Li
L
Wan
D004564:Electrocoagulation; D006801:Humans; D006987:Hypesthesia; D061208:Pulsed Radiofrequency Treatment; D011846:Radio Waves; D016896:Treatment Outcome; D014277:Trigeminal Neuralgia / Q000628:therapy*