Estimated serum vitamin D status, vitamin D intake, and risk of incident alopecia areata among US women.
Studies have identified increased prevalence of vitamin D deficiency in patients with alopecia areata (AA), an autoimmune disease characterized by hair loss, but none have prospectively examined vitamin D status and incident AA. In 55,929 women in the Nurses' Health Study (NHS), we prospectively evaluated the association between estimated vitamin D status, derived from a prediction model incorporating lifestyle determinants of serum vitamin D, and self-reported incident AA. We evaluated dietary, supplemental, and total vitamin D intake as additional exposures. Using Cox proportional hazards models, we calculated age-adjusted and multivariate hazard ratios (HR) to evaluate risk of AA. We identified 133 cases of AA over a follow-up of 12 years. The age-adjusted HR between top vs. bottom quartiles for serum vitamin D score was 0.94 (95 % CI 0.60-1.48) and the corresponding multivariate HR was 1.08 (95 % CI 0.68-1.73). There was no significant association between dietary, supplemental, or total vitamin D intake and incident AA. This study does not support a preventive role for vitamin D in the risk of developing AA.
Warren Alpert Medical School, Brown University, Providence, RI, 02903, USA.
Jordan M
JM
Thompson
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Tricia
T
Li
Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, RI, 02903, USA.
Min Kyung
MK
Park
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.|Department of Epidemiology, School of Public Health, Brown University, Providence, RI, 02903, USA.|Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, RI, 02903, USA.
Abrar A
AA
Qureshi
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA. eunyoung_cho@brown.edu.|Department of Epidemiology, School of Public Health, Brown University, Providence, RI, 02903, USA. eunyoung_cho@brown.edu.|Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, RI, 02903, USA. eunyoung_cho@brown.edu.
Eunyoung
E
Cho
D000368:Aged; D000506:Alopecia Areata / Q000453:epidemiology*; D019587:Dietary Supplements; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D064167:Recommended Dietary Allowances; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000453:epidemiology
D014807:Vitamin D; C104450:25-hydroxyvitamin D
Alopecia areata; Epidemiology; Nurses’ Health Study; Vitamin D