Does the Gut Microbiota Contribute to Obesity? Going beyond the Gut Feeling.
Increasing evidence suggests that gut microbiota is an environmental factor that plays a crucial role in obesity. However, the aetiology of obesity is rather complex and depends on different factors. Furthermore, there is a lack of consensus about the exact role that this microbial community plays in the host. The aim of this review is to present evidence about what has been characterized, compositionally and functionally, as obese gut microbiota. In addition, the different reasons explaining the so-far unclear role are discussed considering evidence from in vitro, animal and human studies.
Top Institute of Food and Nutrition, P.O. Box 557, 6700 AA Wageningen, The Netherlands. Marisol.aguirremorales@tno.nl.|School of Nutrition and Translational Research in Metabolism (NUTRIM), Faculty of Health, Medicine and Life Sciences, Department of Human Biology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands. Marisol.aguirremorales@tno.nl.|The Netherlands Organization for Applied Scientific Research (TNO), P.O. Box 360, 3700 AJ Zeist, The Netherlands. Marisol.aguirremorales@tno.nl.
Marisol
M
Aguirre
Top Institute of Food and Nutrition, P.O. Box 557, 6700 AA Wageningen, The Netherlands. koen.venema@outlook.com.|Beneficial Microbes Consultancy, Johan Karschstraat 3, 6709 TN Wageningen, The Netherlands. koen.venema@outlook.com.
Koen
K
Venema
energy balance; gut microbiota; metabolism; microbial ecology; obesity
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