Modelling drug flux through microporated skin.
A simple mathematical equation has been developed to predict drug flux through microporated skin. The theoretical model is based on an approach applied previously to water evaporation through leaf stomata. Pore density, pore radius and drug molecular weight are key model parameters. The predictions of the model were compared with results derived from a simple, intuitive method using porated area alone to estimate the flux enhancement. It is shown that the new approach predicts significantly higher fluxes than the intuitive analysis, with transport being proportional to the total pore perimeter rather than area as intuitively anticipated. Predicted fluxes were in good general agreement with experimental data on drug delivery from the literature, and were quantitatively closer to the measured values than those derived from the intuitive, area-based approach.
School of Pharmacy, Griffith University, Gold Coast, Queensland 4222, Australia.
Alexey S
AS
Rzhevskiy
Department of Pharmacy & Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom.
Richard H
RH
Guy
School of Natural Sciences, Griffith University, Gold Coast, Queensland 4222, Australia. Electronic address: y.anissimov@griffith.edu.au.
Yuri G
YG
Anissimov
D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D066298:In Vitro Techniques; D053685:Laser Therapy; D008954:Models, Biological; D009339:Needles; D010539:Permeability; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism; D016062:Porosity; D011237:Predictive Value of Tests; D051381:Rats; D012867:Skin / Q000737:chemistry* / Q000378:metabolism* / Q000648:ultrastructure; D012869:Skin Absorption; D013552:Swine
D004364:Pharmaceutical Preparations
Mathematical modelling; Microporation; Percutaneous penetration; Skin flux enhancement; Transdermal drug delivery