Hypoplastic Internal Carotid Artery Co-Presenting with Neurofibromatosis and Intracranial Masses.
Neurofibromatosis type 1 (NF1) is associated with systemic vascular disease, and it can also affect intracranial vasculature in a small percentage of patients. Very rarely, NF1 may co-present with hypoplasia of the internal carotid artery (ICA). Prior reports have documented NF1 with bilateral optic gliomas and a unilateral hypoplastic internal carotid artery; however, we report a case with the aforementioned findings in addition to a right-sided lentiform mass. This case report further suggests a common congenital pathway related to neurofibromin loss of function resulting in both nerve sheath tumors and cerebrovascular anomalies.
Department of Neurosurgery, University of California, San Diego.
Arvin R
AR
Wali
Department of Neurosurgery, University of California, San Diego.
David R
DR
Santiago-Dieppa
Department of Neurosurgery, University of California, San Diego.
Jeffrey A
JA
Steinberg
School of Medicine, University of California, San Diego.
Ali
A
Alattar
Department of Neurosurgery, University of California, San Diego.
Vincent J
VJ
Cheung
Department of Neurosurgery, University of California, San Diego.
Royya
R
Modir
Department of Neurosurgery, University of California, San Diego.
Alexander A
AA
Khalessi
Department of Neurosurgery, University of California, San Diego.
J Scott
JS
Pannell
aplastic internal carotid artery; hypoplastic internal carotid artery; intracranial mass; intracranial vascular malformations; lentiform mass; nerve sheath tumor; neurofibromatosis; neurofibromin; neurovascular abnormalities; optic glioma
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