Application of matrix solid-phase dispersion followed by GC-MS/MS to the analysis of emerging contaminants in vegetables.
A multiresidue method for the determination of 17 emerging contaminants in vegetables was developed based on ultrasound-assisted matrix solid-phase dispersion (MSPD). The analysis was performed using isotope dilution gas chromatography tandem mass spectrometry. In the development of the MSPD procedure, different parameters such as sonication and the type of sorbent or extraction solvent were assayed. Manual and in situ derivatization was assayed and the chromatographic response was higher when the reaction takes place in the injection port. The limits of detection obtained for the studied compounds were in the range of 0.1-0.4ngg(-1) for the different vegetables analyzed. The developed method was applied to vegetables obtained from several local markets. At least one of the organophosphates was detected in the analyzed samples at levels ranging from 0.6 to 4.6ngg(-1) and bisphenol A was detected in all the samples at concentration up to 16ngg(-1).
Departamento de Medio Ambiente, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ctra. de la Coruña km 7, 28040 Madrid, Spain.
Beatriz
B
Albero
Departamento de Medio Ambiente, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ctra. de la Coruña km 7, 28040 Madrid, Spain.
Consuelo
C
Sánchez-Brunete
Departamento de Medio Ambiente, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ctra. de la Coruña km 7, 28040 Madrid, Spain.
Esther
E
Miguel
Departamento de Medio Ambiente, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ctra. de la Coruña km 7, 28040 Madrid, Spain. Electronic address: tadeo@inia.es.
José L
JL
Tadeo
D001559:Benzhydryl Compounds / Q000032:analysis* / Q000302:isolation & purification*; D005506:Food Contamination / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry; D010636:Phenols / Q000032:analysis* / Q000302:isolation & purification*; D052616:Solid Phase Extraction / Q000295:instrumentation / Q000379:methods*; D053719:Tandem Mass Spectrometry / Q000379:methods; D014675:Vegetables / Q000737:chemistry*; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
Bisphenol A (PubChem CID: 6623); Diclofenac (PubChem CID: 3033); Emerging contaminants; Estradiol (PubChem CID: 5757); Estrone (PubChem CID: 5870); Ethinylestradiol (PubChem CID: 5991); Fenofibrate (PubChem CID: 3339); Gas chromatography–tandem mass spectrometry; Ibuprofen (PubChem CID: 3672); Tri-n-butyl phosphate (PubChem CID: 31357); Triclosan (PubChem CID: 5564); Tris(1-chloro-2-propyl) phosphate (PubChem CID: 26176); Ultrasound-assisted matrix solid-phase dispersion; Vegetables