Effect of vitreomacular adhesion and vitreous gel on age-related reduction of macular thickness: a retrospective observational study.
To investigate the effects of vitreomacular adhesion (VMA), vitreomacular separation (VMS) and absence of vitreous gel due to vitrectomy on macular thickness measured in the spectral domain optical coherence tomographic (SD-OCT) images.



A longitudinal, retrospective, observational study.



Secondary multicentre study.



218 eyes of 218 healthy patients and 119 vitrectomised eyes of 119 patients were studied. The healthy individuals were classified into a VMA group (54 eyes) and a VMS group (164 eyes), while the vitrectomised patients were classified into an internal limiting membrane (ILM)-on group (26 eyes) and an ILM-off group (93 eyes). In all participants, 2 Cirrus HD-OCT recordings were made with an average interval of 36 months (range 24-60 months).



The primary outcome measure was the rate of change in macular thickness in the central sector. The secondary outcomes were the rates of change in macular thickness in the inner 4 sectors.



The annual rate of change in the macular thickness of the central sector was 0.76±1.8 µm/year in the VMA group, -0.58±2.3 µm/year in the VMS group, -1.57±1.9 µm/year in the ILM-on group and -0.86±3.1 µm/year in the ILM-off group. There was a significant difference between the rate of the central sector thickness change in the VMA and VMS groups (p=0.0001). The presence of VMA was a significant factor associated with an increase in the central sector thickness (p=0.0055). When the healthy and ILM-on groups were compared, the rate of decrease in the central sector thickness was faster in the ILM-on group (p=0.0043). Multiple regression analyses showed that not peeling the ILM during the vitrectomy was a significant factor associated with a decrease in the central sector thickness (p=0.044).



The presence of a VMA and a vitreous gel may help restrain the macular thickness reduction.
Kami-iida Daiichi General Hospital, Aichi, Japan.
Kazuyuki
K
Kumagai
Department of Ophthalmology, Faculty of Medicine, Saitama Medical University, Iruma, Japan.
Masanori
M
Hangai
Kami-iida Daiichi General Hospital, Aichi, Japan.
Mariko
M
Furukawa
Kami-iida Daiichi General Hospital, Aichi, Japan.
Tetsuyuki
0000-0003-3682-3167
T
Suetsugu
Shinjo Ophthalmologic Institute, Miyazaki, Japan.
Nobuchika
N
Ogino
D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007564:Japan; D008137:Longitudinal Studies; D008266:Macula Lutea / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012044:Regression Analysis; D012160:Retina / Q000000981:diagnostic imaging*; D012189:Retrospective Studies; D000267:Tissue Adhesions / Q000000981:diagnostic imaging*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity; D014821:Vitrectomy
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