Individualizing therapies with responsive epilepsy neurostimulation - A mirtazapine case study of hippocampal excitability.
OBJECTIVE
This study aimed to investigate mirtazapine-induced changes in responsive neurostimulator (RNS) recordings in a patient with epilepsy.


METHODS
Cortical detection/stimulation counts from an RNS implanted in a patient with bitemporal epilepsy were matched to mirtazapine use to see if that drug altered hippocampal excitability.


RESULTS
Mirtazapine decreased hippocampal stability; when mirtazapine was held after a washout period, DSC counts declined, but when it was retrialed, DSC counts increased. Responsive epilepsy neurostimulator system data helped design an optimal and individualized medication regimen for our patient with drug-resistant focal epilepsy.


CONCLUSIONS
Responsive neurostimulator systems in epilepsy may assess a medication's effect on hippocampal excitability. Mirtazapine worsened hippocampal excitability in a patient with bitemporal epilepsy.
Nicole M
NM
Warner
Ryder P
RP
Gwinn
Michael J
MJ
Doherty
Epilepsy; Medication; Mirtazapine; Neurostimulation; Safety; Therapy
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