IgG4-related intraocular inflammation masquerading as ciliary body melanoma in a young girl.
Immunoglobulin G4 (IgG4-related diseases) affects various tissues and organs of the human body. Orbital, adnexal, and scleral inflammations were already reported in the medical literature. To the best of our knowledge, we report the first case of intraocular IgG4-associated inflammatory mass in the ciliary body mimicking as a melanoma in a 23-year-old female from Northeast India. Characteristic histopathology, immunohistochemistry in the tissue, protein chemistry, and raised serum IgG4 were supportive for the diagnosis. As this newly diagnosed disease has multi-organ affection and little is known about its pathogenesis particularly in eye and adnexa, the present case will open many challenges in clinico-pathological diagnosis and research in the future.
Department of Ocular Pathology, Sri Sankaradeva Nethralaya, Guwahati, Assam, India.
Dipankar
D
Das
Department of Ocular Pathology, Sri Sankaradeva Nethralaya, Guwahati, Assam, India.
Panna
P
Deka
SRL, Mumbai, Maharashtra, India.
Geeta
G
Verma
Sri Sankaradeva Nethralaya, Guwahati, Assam, India.
Ganesh Chandra
GC
Kuri
Sri Sankaradeva Nethralaya, Guwahati, Assam, India.
Harsha
H
Bhattacharjee
Sri Sankaradeva Nethralaya, Guwahati, Assam, India.
Gayatri
G
Bharali
Sri Sankaradeva Nethralaya, Guwahati, Assam, India.
Divya
D
Pandey
Sri Sankaradeva Nethralaya, Guwahati, Assam, India.
Akanksha
A
Koul
Sri Sankaradeva Nethralaya, Guwahati, Assam, India.
Bidisha
B
Das
Department of Ocular Pathology, Sri Sankaradeva Nethralaya, Guwahati, Assam, India.
Apurba
A
Deka
D001327:Autoimmune Diseases / Q000175:diagnosis*; D002924:Ciliary Body / Q000473:pathology*; D003937:Diagnosis, Differential; D015353:Eye Enucleation; D005260:Female; D006801:Humans; D007074:Immunoglobulin G; D008279:Magnetic Resonance Imaging; D008545:Melanoma / Q000175:diagnosis*; D014604:Uveal Neoplasms / Q000175:diagnosis*; D014606:Uveitis, Anterior / Q000175:diagnosis*; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult; D000098943:Uveal Melanoma
D007074:Immunoglobulin G
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