Nucleolar Methyltransferase Fibrillarin: Evolution of Structure and Functions.
Fibrillarin is one of the most studied nucleolar proteins. Its main functions are methylation and processing of pre-rRNA. Fibrillarin is a highly conserved protein; however, in the course of evolution from archaea to eukaryotes, it acquired an additional N-terminal glycine and arginine-rich (GAR) domain. In this review, we discuss the evolution of fibrillarin structure and its relation to the functions of the protein in prokaryotes and eukaryotes.
Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics, Moscow, 119991, Russia. mariashubina23@gmail.com.
M Y
MY
Shubina
Y R
YR
Musinova
E V
EV
Sheval
D000818:Animals; D002868:Chromosomal Proteins, Non-Histone / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D019143:Evolution, Molecular; D006801:Humans; D000072417:Protein Domains; D012322:RNA Precursors / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics; D013329:Structure-Activity Relationship; D012359:tRNA Methyltransferases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
D002868:Chromosomal Proteins, Non-Histone; D012322:RNA Precursors; C047458:fibrillarin; D012359:tRNA Methyltransferases