Bacterial Etiology and Antibiotic Resistance Profile of Community-Acquired Urinary Tract Infections in a Cameroonian City.
Introduction. Community-acquired urinary tract infections (CAUTIs) are usually treated empirically. Geographical variations in etiologic agents and their antibiotic sensitivity patterns are common. Knowledge of antibiotic resistance trends is important for improving evidence-based recommendations for empirical treatment of UTIs. Our aim was to determine the major bacterial etiologies of CAUTIs and their antibiotic resistance patterns in a cosmopolitan area of Cameroon for comparison with prescription practices of local physicians. Methods. We performed a cross-sectional descriptive study at two main hospitals in Yaoundé, collecting a clean-catch mid-stream urine sample from 92 patients having a clinical diagnosis of UTI. The empirical antibiotherapy was noted, and identification of bacterial species was done on CLED agar; antibiotic susceptibility testing was performed using the Kirby-Bauer disc diffusion method. Results. A total of 55 patients had samples positive for a UTI. Ciprofloxacin and amoxicillin/clavulanic acid were the most empirically prescribed antibiotics (30.9% and 23.6%, resp.); bacterial isolates showed high prevalence of resistance to both compounds. Escherichia coli (50.9%) was the most common pathogen, followed by Klebsiella pneumoniae (16.4%). Prevalence of resistance for ciprofloxacin was higher compared to newer quinolones. Conclusions. E. coli and K. pneumoniae were the predominant bacterial etiologies; the prevalence of resistance to commonly prescribed antibiotics was high.
Faculty of Medicine and Biomedical Sciences, Yaoundé, Cameroon.
Rolf Nyah-Tuku
0000-0002-3752-054X
RN
Nzalie
Faculty of Medicine and Biomedical Sciences, Yaoundé, Cameroon; Microbiology Laboratory, Yaoundé University Hospital Centre, Yaoundé, Cameroon.
Hortense Kamga
HK
Gonsu
Faculty of Medicine and Biomedical Sciences, Yaoundé, Cameroon; Infectious Disease Unit, Yaoundé Central Hospital, Yaoundé, Cameroon; National Research Agency on AIDS and Viral Hepatitis, Yaoundé, Cameroon.
Sinata
S
Koulla-Shiro
Trop Med Int Health. 2005 Jan;10(1):74-81
15655016
N Am J Med Sci. 2011 Feb;3(2):75-7
22540069
Clin Infect Dis. 2011 Mar 1;52(5):e103-20
21292654
BMC Res Notes. 2012 May 07;5:219
22564344
JAMA. 1999 Feb 24;281(8):736-8
10052444
J Antimicrob Chemother. 2003 Jan;51(1):192-4
12493816
Nat Rev Urol. 2010 Dec;7(12):653-60
21139641
S Afr Med J. 2013 Mar 15;103(6):377-81
23725955
Am J Trop Med Hyg. 2011 Jun;84(6):923-8
21633029
J Antimicrob Chemother. 2001 Jul;48(1):37-45
11418511
Int J Infect Dis. 2004 May;8(3):147-54
15109589
Infect Dis Clin North Am. 2003 Jun;17(2):243-59
12848469
Antimicrob Agents Chemother. 1999 Feb;43(2):421-3
9925551
Antimicrob Agents Chemother. 2001 Jun;45(6):1654-9
11353608
Ann Clin Microbiol Antimicrob. 2007 Mar 23;6:4
17378940
BMC Infect Dis. 2013 Apr 29;13:193
23627344
Singapore Med J. 2011 Jun;52(6):415-20
21731993