The effects of anxiety and depression on in vitro fertilisation outcomes of infertile Chinese women.
The object was to assess anxiety and depression during in vitro fertilisation (IVF) treatment and determine IVF-related psychological factors in infertile Chinese women. The self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were used to evaluate anxiety and depression among 842 patients, respectively. A univariate analysis was used to compare variables among three SAS groups and three SDS groups. Anxiety and depression were both represented in 21.3% of the cases. Patients <35 years tended to be more anxious. In women <35 years, the SDS scores were higher with lower educational backgrounds and female or couple's infertility, while the SAS scores were higher in female or couple's infertility. In older ones, the SDS scores were higher in those with lower educational backgrounds and longer time for infertility, while the SAS scores were higher in those with lower educational backgrounds. In SAS groups 1-3, the embryo availability was 5.0 (3.0-8.0), 5.0 (3.0-8.0), and 3.0 (2.0-4.5) (p = .013); and the fertilisation rate was 91.9, 90.4, and 81.8% (p < .001), respectively. We concluded that infertile women experience anxiety and depression during IVF treatment, especially in women <35 years. Younger women with female infertility would be more anxious and depressive while higher education can protect them from depression. In older ones, they would experience more depressive with longer time for infertility and be less anxious and depressive with higher education. Anxiety affects the fertilisation rate and embryo availability.
a Reproductive Medicine Center, Department of Obstetrics and Gynecology , Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , Guangzhou , P. R. China.|b Department of Obstetrics and Gynecology, Fuzhou General Hospital of Nanjing Military , Fujian , P. R. China.
Hongmei
H
Xu
a Reproductive Medicine Center, Department of Obstetrics and Gynecology , Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , Guangzhou , P. R. China.
Nengyong
N
Ouyang
a Reproductive Medicine Center, Department of Obstetrics and Gynecology , Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , Guangzhou , P. R. China.
Ruiqi
R
Li
c Reproductive Medicine Center, Wuhan General Hospital of Guangzhou Military , Hubei , P. R. China.
Ping
P
Tuo
a Reproductive Medicine Center, Department of Obstetrics and Gynecology , Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , Guangzhou , P. R. China.
Meiqi
M
Mai
a Reproductive Medicine Center, Department of Obstetrics and Gynecology , Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , Guangzhou , P. R. China.
Wenjun
W
Wang
D000328:Adult; D001007:Anxiety / Q000453:epidemiology / Q000523:psychology*; D002681:China / Q000453:epidemiology; D003863:Depression / Q000453:epidemiology / Q000523:psychology*; D005260:Female; D005307:Fertilization in Vitro / Q000523:psychology* / Q000706:statistics & numerical data; D006801:Humans; D007247:Infertility, Female / Q000453:epidemiology / Q000523:psychology*; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data
Anxiety; depression; fertilisation in vitro; infertility; pregnancy; psychological status