Anti-Inflammation of Natural Components from Medicinal Plants at Low Concentrations in Brain via Inhibiting Neutrophil Infiltration after Stroke.
Inflammation after stroke consists of activation of microglia/astrocytesin situand infiltration of blood-borne leukocytes, resulting in brain damage and neurological deficits. Mounting data demonstrated that most natural components from medicinal plants had anti-inflammatory effects after ischemic stroke through inhibiting activation of resident microglia/astrocytes within ischemic area. However, it is speculated that this classical activity cannot account for the anti-inflammatory function of these natural components in the cerebral parenchyma, where they are detected at very low concentrations due to their poor membrane permeability and slight leakage of BBB. Could these drugs exert anti-inflammatory effects peripherally without being delivered across the BBB? Factually, ameliorating blood-borne neutrophil recruitment in peripheral circulatory system has been proved to reduce ischemic damage and improve outcomes. Thus, it is concluded that if drugs could achieve effective concentrations in the cerebral parenchyma, they can function via crippling resident microglia/astrocytes activation and inhibiting neutrophil infiltration, whereas the latter will be dominating when these drugs localize in the brain at a low concentration. In this review, the availability of some natural components crossing the BBB in stroke will be discussed, and how these drugs lead to improvements in stroke through inhibition of neutrophil rolling, adhesion, and transmigration will be illustrated.
Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China.
Jiannan
J
Chen
Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China; Hebei Collaborative Innovation Center for Cardiocerebrovascular Disease, Shijiazhuang, Hebei 050000, China; Hebei Vascular Homeostasis Key Laboratory for Neurology, Shijiazhuang, Hebei 050000, China.
Xiangjian
0000-0003-0114-1668
X
Zhang
Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China.
Cong
C
Zhang
Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China.
Wenhui
0000-0001-7482-692X
W
Wang
Hebei Collaborative Innovation Center for Cardiocerebrovascular Disease, Shijiazhuang, Hebei 050000, China; Hebei Vascular Homeostasis Key Laboratory for Neurology, Shijiazhuang, Hebei 050000, China.
Rong
R
Chen
Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China.
Honglei
H
Jiao
Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China.
Linlin
L
Li
Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China.
Lan
L
Zhang
Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China; Hebei Vascular Homeostasis Key Laboratory for Neurology, Shijiazhuang, Hebei 050000, China.
Lili
L
Cui
Eur J Pharmacol. 2009 Aug 15;616(1-3):147-54
19577560
Expert Opin Biol Ther. 2010 Jun;10(6):937-49
20394473
PLoS One. 2014 Jun 30;9(6):e101194
24979385
Mol Neurobiol. 2016 May;53(4):2529-40
26081140
Stroke. 1994 Sep;25(9):1794-8
7521076
J Nutr Biochem. 2012 May;23(5):469-77
21684135
Zhongguo Zhong Yao Za Zhi. 2011 Jun;36(12):1650-3
22007554
PLoS One. 2014 Jul 03;9(7):e101504
24991819
Cell Biochem Biophys. 2012 Jan;62(1):137-40
21874590
Curr Drug Metab. 2012 Jun 1;13(5):577-98
22292787
Yao Xue Xue Bao. 2010 Jul;45(7):940-4
20931796
J Neuroimmunol. 1995 Feb;56(2):127-34
7860708
J Cereb Blood Flow Metab. 2015 Jun;35(6):888-901
25806703
Neurochem Int. 2012 Apr;60(5):458-65
22342823
Dev Neurobiol. 2010 Apr;70(5):384-96
20186710
J Cereb Blood Flow Metab. 2002 Jul;22(7):785-97
12142564
Immunol Lett. 1986 Aug;13(1-2):83-8
3759146
Fitoterapia. 2013 Jan;84:107-14
23160090
Microcirculation. 2009 May;16(4):364-76
19308793
BMC Neurosci. 2010 Feb 02;11:12
20122276
Stroke. 1991 Oct;22(10):1276-83
1926239
Acta Pharmacol Sin. 2004 Jul;25(7):869-75
15210059
Chem Soc Rev. 2009 Apr;38(4):1152-61
19421586
J Exp Med. 2012 Apr 9;209(4):819-35
22451716
Prog Neurobiol. 2007 Dec;83(6):349-62
17884277
Nature. 2010 Oct 21;467(7318):972-6
20927103
Stroke. 2000 Dec;31(12):3047-53
11108771
Chin J Integr Med. 2016 Jan;22(1):36-41
26015073
Brain Res Bull. 1993;31(5):565-72
8495380
Br J Pharmacol. 1999 Dec;128(7):1593-601
10602341
Eur J Pharmacol. 1998 Mar 12;345(1):89-95
9593599
Stroke. 2002 Feb;33(2):586-92
11823674
Trends Neurosci. 1999 Sep;22(9):391-7
10441299
J Neurochem. 2015 Apr;133(1):93-103
25626516
Adv Neurol. 1996;71:301-11; discussion 311-3
8790807
J Neuroinflammation. 2013 Sep 18;10:115
24047275
J Pharmacobiodyn. 1990 Feb;13(2):142-57
2384851
Inflammation. 2015 Apr;38(2):846-57
25117567
Biol Res Nurs. 2011 Apr;13(2):154-63
21044968
Stroke. 1998 Oct;29(10):2189-95
9756602
J Neuroimmune Pharmacol. 2014 Jun;9(3):313-39
24562591
Med Hypotheses. 2008 Nov;71(5):762-4
18762387
Science. 2010 Oct 15;330(6002):362-6
20947763
Int Immunopharmacol. 2013 Dec;17(4):1167-75
23863858
Ann Neurol. 2012 Nov;72(5):648-72
23280789
Brain Res. 2015 May 22;1608:203-14
25727173
NeuroRx. 2005 Jul;2(3):396-409
16389304
Circulation. 2014 Jan 21;129(3):e28-e292
24352519
Stroke. 1999 Jan;30(1):134-9
9880401
J Cereb Blood Flow Metab. 2006 Jun;26(6):797-810
16192992
Evid Based Complement Alternat Med. 2015;2015:385154
26074989
Brain Res Bull. 2010 Oct 30;83(5):196-201
20637265
Brain Res Brain Res Rev. 2001 Oct;36(2-3):258-64
11690623
Am J Chin Med. 2015 ;43(7):1419-38
26477799
Agents Actions. 1978 Dec;8(6):610-7
742558
Circ Res. 2002 Nov 15;91(10):907-14
12433835
Stroke. 1995 Aug;26(8):1438-42; discussion 1443
7631350
J Cereb Blood Flow Metab. 2004 Dec;24(12):1359-68
15625410
Yao Xue Xue Bao. 2004 Jun;39(6):419-23
15491097
J Pharm Biomed Anal. 2007 Oct 18;45(2):349-55
17596900
Mediators Inflamm. 2014;2014:370530
24876671
Am J Chin Med. 2010;38(3):517-27
20503469
J Neuroimmune Pharmacol. 2007 Sep;2(3):284-9
18040863
Cell Death Dis. 2014 Jul 03;5:e1312
24991764
Stroke. 1995 Apr;26(4):661-5; discussion 665-6
7709415
Circulation. 2013 Jan 1;127(1):e6-e245
23239837
Molecules. 2016 Feb 05;21(2):null
26861272
Chem Pharm Bull (Tokyo). 1988 Jan;36(1):440-3
3378305
J Cereb Blood Flow Metab. 2010 Aug;30(8):1412-31
20485296
J Transl Med. 2009 Nov 17;7:97
19919699
Blood. 2011 Dec 22;118(26):6743-51
22021370
Mediators Inflamm. 2015 ;2015 :274314
25960613
Yao Xue Xue Bao. 2004 Mar;39(3):217-9
15171659
Acta Neuropathol. 2009 May;117(5):481-96
19142647
Mol Pharmacol. 1999 Jan;55(1):186-93
9882713
Biochem Biophys Res Commun. 2011 Dec 2;415(4):602-7
22074828
J Mol Neurosci. 2011 Jun;44(2):130-9
21318404
Cytokine. 2013 Mar;61(3):970-7
23434274
Anat Cell Biol. 2011 Dec;44(4):304-13
22254159
Neurosci Lett. 2004 Jun 17;363(3):218-23
15182947
J Vis Exp. 2014 Jul 31;(89):e51729
25145316
J Orthop Sci. 2008 Sep;13(5):456-62
18843461
Neurosci Lett. 2014 Mar 6;562:39-44
24412680
J Orthop Sci. 2006 Jul;11(4):375-9
16897202
Int J Neurosci. 2013 Nov;123(11):745-51
23594088
Infect Genet Evol. 2015 Oct;35:194-203
26296608
Stroke. 2006 Jul;37(7):1917-22
16728683
J Cereb Blood Flow Metab. 2002 Mar;22(3):308-17
11891436
Acupunct Electrother Res. 2001;26(1-2):1-9
11394489
J Immunol. 2012 Jul 1;189(1):381-92
22661091
J Pharm Sci. 1992 Sep;81(9):961-3
1432649
J Cereb Blood Flow Metab. 2012 Sep;32(9):1677-98
22739623
J Med Food. 2012 Oct;15(10 ):894-900
22985397
Biomedicine (Taipei). 2014;4:16
25520929
Mol Cell Neurosci. 2013 Mar;53:26-33
22940669
Cell Physiol Biochem. 2015 ;35(4):1335-46
25720416
Thromb Haemost. 2003 Nov;90(5):904-14
14597987
Nat Rev Immunol. 2013 Mar;13(3):159-75
23435331
Chem Pharm Bull (Tokyo). 1989 Jan;37(1):226-8
2720854
Neurol Neurochir Pol. 2004;38(1 Suppl 1):S57-62
15045869
Surg Neurol. 2006 Sep;66(3):232-45
16935624
Neuroscience. 2012 Jan 27;202:342-51
22173011
Nat Med. 2011 Jul 07;17(7):796-808
21738161
J Leukoc Biol. 2011 Mar;89(3):359-72
21097697
Nat Rev Immunol. 2007 Sep;7(9):678-89
17717539
Neurol Sci. 2013 Sep;34(9):1509-16
23619532
J Cereb Blood Flow Metab. 1999 Aug;19(8):819-34
10458589
Acta Neuropathol. 1985;68(2):122-9
3907257
Stroke. 1995 Apr;26(4):676-80; discussion 681
7709417
Neuron. 2014 May 7;82(3):603-17
24746419
Atherosclerosis. 2012 Jun;222(2):464-7
22460048
Blood. 2012 Sep 6;120(10):2133-43
22837532
J Surg Res. 2011 Jan;165(1):e29-35
21074783
Phytother Res. 2016 May;30(5):790-6
26806653
Brain Res Mol Brain Res. 1994 Oct;26(1-2):61-8
7854067
Atherosclerosis. 2002 Mar;161(1):161-8
11882328
PLoS One. 2013 Jun 06;8(6):e64631
23785403
J Neuroimmunol. 1997 Apr;74(1-2):35-44
9119977
J Cereb Blood Flow Metab. 2012 Nov;32(11):1959-72
22929442
Neurobiol Dis. 2008 Nov;32(2):200-19
18790057
J Cereb Blood Flow Metab. 1998 Dec;18(12):1336-45
9850146
Neuropathol Appl Neurobiol. 2012 Oct;38(6):617-27
22289071
Mol Pharmacol. 2001 Nov;60(5):1083-90
11641437
Exp Neurol. 1998 Oct;153(2):223-33
9784282
Br J Nutr. 2008 Apr;99(4):782-92
17977475
Neurosci Lett. 1997 Apr 18;226(1):33-6
9153635
Cerebrovasc Brain Metab Rev. 1994 Spring;6(1):47-96
8186069
J Neurosci. 2001 Aug 1;21(15):5528-34
11466424
Brain Behav Immun. 2011 Feb;25(2):260-9
20869431
Molecules. 2011 Sep 16;16(9):8020-32
21926947
J Cardiovasc Pharmacol. 2001 Dec;38(6):947-55
11707699
Int J Stroke. 2012 Jul;7(5):378-85
22712739
J Cereb Blood Flow Metab. 2014 Apr;34(4):660-7
24424382
Acta Pharmacol Sin. 2001 Nov;22(11):971-5
11749785