p62 Regulates the Proliferation of Molecular Apocrine Breast Cancer Cells.
p62, also called sequestosome 1 (SQSTM1), is a multifunctional signaling molecule that affects cell proliferation. Recently, we found accumulation of p62 in apocrine carcinoma of the breast, however, the biological role of p62 expression in apocrine carcinoma still remains unclear. To investigate whether p62 might contribute to tumor cell proliferation in apocrine carcinomas, we used the MDA-MB-453 (androgen receptor-positive, HER2-type) and MFM223 (androgen receptor-positive, triple-negative type) breast cancer cell lines as models of molecular apocrine carcinoma. Both MDA-MB-453 and MFM223 showed strong and d high p62 protein expression than MCF7 cells (androgen receptor-negative, luminal A type). Knockdown of p62 resulted in significant reduction of the cell proliferative activity in both MDA-MB-453 (P<0.01) and MFM223 (P<0.05). In conclusion, p62 could contribute to cell proliferation and represent a therapeutic target in apocrine carcinoma.
Department of Pathology, St. Luke's International Hospital, Tokyo, Japan; Department of Oncologic Pathology, Nihon University School of Medicine, Tokyo, Japan.
Fumi
F
Nozaki
Division of Morphological and Functional Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine , Tokyo, Japan.
Yukari
Y
Hirotani
Department of Oncologic Pathology, Nihon University School of Medicine , Tokyo, Japan.
Yoko
Y
Nakanishi
Division of Morphological and Functional Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine , Tokyo, Japan.
Hiromi
H
Yamaguchi
Department of Oncologic Pathology, Nihon University School of Medicine , Tokyo, Japan.
Haruna
H
Nishimaki
Department of Oncologic Pathology, Nihon University School of Medicine , Tokyo, Japan.
Hiroko
H
Noda
Department of Oncologic Pathology, Nihon University School of Medicine , Tokyo, Japan.
Xiaoyan
X
Tang
Division of Pathology, Nihon University Itabashi Hospital , Tokyo, Japan.
Hisae
H
Yamamoto
Division of Pathology, Nihon University Itabashi Hospital , Tokyo, Japan.
Atsuko
A
Suzuki
Division of Pathology, Nihon University Itabashi Hospital , Tokyo, Japan.
Toshimi
T
Seki
Department of Oncologic Pathology, Nihon University School of Medicine , Tokyo, Japan.
Shinobu
S
Masuda
apocrine carcinoma; breast cancer; p62
Pathol Int. 2015 Jan;65(1):19-26
25516445
J Biol Chem. 2010 Jan 15;285(3):2077-89
19903815
Oncogene. 2015 Jun 4;34(23 ):2968-77
25088198
Cancer Sci. 2012 Apr;103(4):760-6
22320446
PLoS One. 2014 Jan 24;9(1):e86641
24475161
Cell. 2011 Nov 11;147(4):728-41
22078875
J Clin Oncol. 2007 Jan 1;25(1):118-45
17159189
Cancer Cell. 2013 Dec 9;24(6):738-50
24332042
Cell. 2007 Dec 14;131(6):1149-63
18083104
Oncogene. 2012 Mar 1;31(9):1196-206
21785460
Oncogene. 2005 Jul 7;24(29):4660-71
15897907
Nat Cell Biol. 2010 Mar;12 (3):213-23
20173742
Oncogene. 2003 Apr 17;22(15):2322-33
12700667
J Cell Biol. 2011 Apr 18;193(2):275-84
21482715
Onco Targets Ther. 2013 Jul 19;6:883-8
23888115
Mod Pathol. 1998 Feb;11(2):155-68
9504686
Cell. 2009 Jun 12;137(6):1001-4
19524504
BMC Cancer. 2009 Jul 16;9:236
19607694
Oncogene. 2006 Jun 29;25(28):3994-4008
16491124
Histopathology. 2008 Jan;52(1):3-10
18171412
Mod Pathol. 2010 Feb;23(2):205-12
19898421