Correlation between Serum Lipid Levels and Measured Glomerular Filtration Rate in Chinese Patients with Chronic Kidney Disease.
BACKGROUND
Dyslipidemia is often detected in patients with chronic kidney disease (CKD). Previous studies of the relationship between lipid profiles and kidney function have yielded variable results. We aimed to investigate the correlation between serum lipid levels and kidney function evaluated by measured glomerular filtration rate (mGFR) in Chinese patients with CKD.


METHODS
A cross-sectional study was conducted on 2036 Chinese CKD patients who had mGFR. Linear regression analysis was performed to evaluate the correlation between different serum lipid levels and mGFR, while logistic regression analysis was used to investigate the association between CKD stages and the risk of different types of dyslipidemia.


RESULTS
The mean age was 55 years and the mean mGFR was 63 mL/min/1.73m2. After adjusting for some confounders (age, gender, body mass index, a history of diabetes, fasting glucose, a history of hypertension, systolic blood pressure, diastolic blood pressure, smoking status, hemoglobin, serum potassium, serum albumin, and serum uric acid), serum triglyceride level showed a negative correlation with mGFR (β = -0.006, P = 0.006) in linear regression analysis, and CKD stages were positively related to the risk of hypertriglyceridemia (odds ratios were 1.329, 1.868, 2.514 and P were 0.046, < 0.001, < 0.001 for CKD stage 2, 3, 4/5, respectively) in logistic regression anlysis.


CONCLUSIONS
Serum triglyceride level is independently association with mGFR. Patients with reduced kidney function are more likely to have higher serum triglyceride levels. Further longitudinal, multicenter and well-conducted studies are needed to provide more evidence.
Department of Nephrology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.|Department of Nephrology, Hainan General Hospital, Haikou, China.
Yanni
Y
Wang
Department of Laboratory Medicine, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Xilian
X
Qiu
Operation Room, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Linsheng
L
Lv
Department of Nephrology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Caixia
C
Wang
Department of Nephrology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Zengchun
Z
Ye
Department of Nephrology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Shaomin
S
Li
School of Software Engineerning, South China University of Tecchonology, Guangzhou, China.
Qiong
Q
Liu
Department of Nephrology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Tanqi
T
Lou
Department of Nephrology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Xun
X
Liu
D000328:Adult; D000368:Aged; D044466:Asian People; D002681:China; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000097:blood / Q000473:pathology; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000473:pathology; D007668:Kidney / Q000503:physiopathology; D016014:Linear Models; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000150:complications / Q000473:pathology; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*
D008055:Lipids; D014280:Triglycerides
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