From pathogenesis to clinical application: insights into exosomes as transfer vectors in cancer.
Exosomes are nanoscale extracellular membrane vesicles that are created by the fusion of an intracellular multivesicular body with the cell membrane. They are widely distributed in serum, urine, saliva and other biological fluids. As important transfer vectors for intercellular communication and genetic material, exosomes can stimulate target cells directly via receptor-mediated interactions or via the transfer of various bioactive molecules, such as cell membrane receptors, proteins, mRNAs and microRNAs, thus exerting their biological functions. This review focuses on the biological characteristics of exosomes, as well as their role and underlying mechanisms of action in the evolution of tumor formation, metastasis, drug resistance and other malignant behaviors. Additionally, this review emphasizes the potential applications of exosomes in the treatment of tumors. Further research may provide new ideas and methods to establish effective, exosome-based strategies for the early diagnosis and treatment of tumors.
Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, 17 YongWaizheng Street, Nanchang, Jiangxi, 330006, China.
Wenting
W
Xu
Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, 17 YongWaizheng Street, Nanchang, Jiangxi, 330006, China. zyang@ncu.edu.cn.
Zhen
Z
Yang
Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, 17 YongWaizheng Street, Nanchang, Jiangxi, 330006, China. lunonghua@ncu.edu.cn.
Nonghua
N
Lu
Cancer; Exosomes; Transfer vectors
Genes Chromosomes Cancer. 2014 Sep;53(9):713-24
24764226
Int J Cancer. 2013 Jul 15;133(2):416-26
23338841
J Clin Invest. 2013 Apr;123(4):1542-55
23454749
Br J Cancer. 2013 Feb 19;108(3):644-52
23361059
Biomaterials. 2014 Feb;35(7):2383-90
24345736
BMC Cancer. 2009 Jul 20;9:244
19619303
FASEB J. 2016 May;30(5):2058-63
26873936
Mol Med Rep. 2015 Jan;11(1):405-9
25338648
J Clin Invest. 2016 Aug 1;126(8):2805-20
27348586
J Immunol. 2010 Sep 15;185(6):3740-9
20709956
J Biol Chem. 2012 May 4;287(19):15874-85
22396543
J Biol Chem. 1987 Jul 5;262(19):9412-20
3597417
Cell. 2014 Oct 23;159(3):499-513
25417103
Gynecol Oncol. 2011 Aug;122(2):437-46
21601258
J Lipid Res. 2016 Sep;57(9):1659-69
27436590
Mol Ther. 2013 Jan;21(1):101-8
22910294
Cancer. 2013 Mar 15;119(6):1159-67
23224754
Hepatology. 2009 Nov;50(5):1412-20
19708080
J Thorac Oncol. 2013 Sep;8(9):1156-62
23945385
J Transl Med. 2012 Jun 27;10:134
22738135
Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7312-7
23589885
J Extracell Vesicles. 2014 Aug 04;3:null
25143819
J Exp Clin Cancer Res. 2016 Jan 04;35:1
26728266
Nat Med. 2012 Jun;18(6):883-91
22635005
Annu Rev Pharmacol Toxicol. 2015;55:439-64
25292428
Microrna. 2014;2(3):194-204
25069443
Br J Cancer. 2015 Jul 14;113(2):275-81
26057451
Cell Res. 2016 Feb;26(2):149-50
26704450
Oncotarget. 2014 Oct 30;5(20):9650-63
25333260
Mol Med Rep. 2016 Oct;14 (4):3452-8
27513187
World J Surg Oncol. 2013 Sep 04;11:219
24007214
Asian Pac J Cancer Prev. 2013;14(1):309-14
23534743
Brain. 2006 Sep;129(Pt 9):2416-25
16891318
J Transl Med. 2005 Feb 21;3(1):9
15723705
Semin Cell Dev Biol. 2015 Apr;40:89-96
25704308
Immunity. 2014 Jul 17;41(1):89-103
25035954
Sci Rep. 2016 Aug 04;6:30816
27487939
Cancer Lett. 2012 Feb 1;315(1):28-37
22055459
PLoS One. 2013 Oct 21;8(10):e78115
24205116
Biomed Res Int. 2014;2014:864894
24963487
J Natl Cancer Inst. 2014 Dec 12;107(1):363
25505237
Cancer Lett. 2016 Jul 1;376(2):318-27
27063098
Int J Oncol. 2012 Jan;40(1):130-8
21904773
Annu Rev Physiol. 2015;77:13-27
25293529
Neuro Oncol. 2014 Apr;16(4):520-7
24435880
Oncotarget. 2014 Jul 30;5(14):5439-52
24978137
Semin Cell Dev Biol. 2015 Apr;40:60-71
25721809
Br J Cancer. 2005 Jan 31;92 (2):305-11
15655551
Anal Biochem. 2014 Mar 1;448:41-9
24333249
J Exp Med. 1996 Mar 1;183(3):1161-72
8642258
Nucleic Acids Res. 2012 Nov;40(21):10937-49
22965126
Methods. 2012 Feb;56(2):293-304
22285593
Blood. 2005 Feb 15;105(4):1734-41
15494427
Cell. 2016 Mar 10;164(6):1226-32
26967288
Oncogene. 2015 May 21;34(21):2690-9
25065597
Front Immunol. 2013 Dec 11;4:438
24376443
J Exp Clin Cancer Res. 2016 Jan 12;35:7
26754670
Science. 2016 Jan 22;351(6271):391-6
26721685
Br J Cancer. 2012 Feb 14;106(4):768-74
22240788
Mol Cancer Ther. 2005 Oct;4(10):1595-604
16227410
J Clin Invest. 2014 Dec;124(12):5109-28
25401471
Genes Cancer. 2013 Jul;4(7-8):261-72
24167654
Cell. 1991 Apr 5;65(1):13-24
1707342
Clin Chem. 2011 Jan;57(1):18-32
21059829
Nat Cell Biol. 2015 Jun;17(6):816-26
25985394
Cell. 2016 Jun 30;166(1):21-45
27368099
Int J Cancer. 2015 Dec 15;137(12):2869-78
26139298
Oncotarget. 2016 Feb 16;7(7):7816-28
26761211
Inflammation. 2013 Feb;36(1):232-40
22956173
Mol Ther. 2013 Jan;21(1):185-91
23032975
Ageing Res Rev. 2016 Dec;32:65-74
27238186
Mol Med Rep. 2013 Oct;8(4):1272-8
23969721
Proteomics. 2009 May;9(10):2820-35
19415654
Blood Rev. 2013 Jan;27(1):31-9
23261067
Nat Commun. 2015 Apr 01;6:6716
25828099
Mol Ther. 2010 Sep;18(9):1606-14
20571541
J Exp Clin Cancer Res. 2015 Apr 02;34:32
25886763
Nat Biotechnol. 2011 Apr;29(4):341-5
21423189
Traffic. 2009 Oct;10(10):1528-42
19682328
PLoS One. 2012;7(3):e33330
22438914
PLoS One. 2010 Jul 22;5(7):e11469
20661468
Oncoimmunology. 2015 Sep 11;5(3):e1086861
27141342
Tumour Biol. 2014 Nov;35(11):10773-9
25077924
PLoS One. 2013 Apr 12;8(4):e61515
23593486
Front Immunol. 2013 Dec 25;4:490
24400010
Nucleic Acids Res. 2012 Oct;40(18):9272-85
22821563
Gynecol Oncol. 2008 Jul;110(1):13-21
18589210
Tumour Biol. 2014 Apr;35(4):2883-92
24272085
Clin Lung Cancer. 2009 Jan;10(1):42-6
19289371
Elife. 2016 Jan 29;5:e07383
26826285
PLoS One. 2014 Apr 04;9(4):e92921
24705249
J Hepatobiliary Pancreat Sci. 2012 Jul;19(4):465-75
21983893
Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3794-9
19234131
Nat Rev Immunol. 2009 Aug;9(8):581-93
19498381
Stem Cells. 2014 Apr;32(4):983-97
24715691
Int J Cancer. 2015 Jun 1;136(11):2616-27
25388097
PLoS One. 2012;7(12):e50999
23251413
Trends Pharmacol Sci. 2016 Jul;37(7):606-17
27157716
Bioscience. 2015 Aug 1;65(8):783-797
26955082
Neoplasia. 2009 Oct;11(10):1093-105
19794968
Biochim Biophys Acta. 1981 Jul 6;645(1):63-70
6266476
Clin Cancer Res. 2005 Oct 15;11(20):7554-63
16243831
Oncotarget. 2016 Mar 22;7(12):14639-58
26840259
J Immunol. 2009 Sep 15;183(6):3720-30
19692638
Cancer Lett. 2013 Jul 10;335(1):201-4
23419525
J Neuroimmunol. 2015 Aug 15;285:71-5
26198922
Nat Commun. 2016 Jul 22;7:12277
27447450
Annu Rev Cell Dev Biol. 2014;30:255-89
25288114
Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10513-8
18663219
J Proteome Res. 2014 Feb 7;13(2):836-43
24295599
Cell Commun Signal. 2013 Nov 18;11:88
24245560
Cent Eur J Immunol. 2014;39(2):142-51
26155115
Nature. 2015 Nov 19;527(7578):329-35
26524530
Stem Cells Dev. 2013 Mar 1;22(5):758-71
23034046
Nat Cell Biol. 2015 Feb;17(2):183-94
25621950
Cancer Res. 2013 Jul 1;73(13):3865-76
23658368
Cancer Res. 2010 Dec 1;70(23):9621-30
21098712