Identified key genes related to carotid atheroma plaque from gene expression chip.
As one of the leading reason in morbidity and death in the world, atherosclerosis is usually associated with vessel stenosis, ulceration, and inflammatory cell infiltration. However, the formation mechanism of atheroma plaque is unknown. In this research, we have used bioinformatics tools to identify 118 differential expression genes from a GEO dataset. Besides, we also revealed KYNU as a crucial gene in atheroma plaque development.
a Department of Vascular Surgery , Changhai Hospital, Second Military Medical University , Shanghai , China.
Jian
J
Dong
a Department of Vascular Surgery , Changhai Hospital, Second Military Medical University , Shanghai , China.
Chao
C
Song
a Department of Vascular Surgery , Changhai Hospital, Second Military Medical University , Shanghai , China.
Lei
L
Zhang
a Department of Vascular Surgery , Changhai Hospital, Second Military Medical University , Shanghai , China.
Xiang
X
Feng
a Department of Vascular Surgery , Changhai Hospital, Second Military Medical University , Shanghai , China.
Rui
R
Feng
a Department of Vascular Surgery , Changhai Hospital, Second Military Medical University , Shanghai , China.
Qingsheng
Q
Lu
a Department of Vascular Surgery , Changhai Hospital, Second Military Medical University , Shanghai , China.|b Department of Surgery , Changhai Hospital, Second Military Medical University , Shanghai , China.
Zhiqing
Z
Zhao
a Department of Vascular Surgery , Changhai Hospital, Second Military Medical University , Shanghai , China.
Junmin
J
Bao
a Department of Vascular Surgery , Changhai Hospital, Second Military Medical University , Shanghai , China.
Jian
J
Zhou
a Department of Vascular Surgery , Changhai Hospital, Second Military Medical University , Shanghai , China.
Zaiping
Z
Jing
D002340:Carotid Artery Diseases / Q000235:genetics / Q000378:metabolism*; D030541:Databases, Genetic; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D058226:Plaque, Atherosclerotic / Q000235:genetics / Q000378:metabolism*
Carotid atheroma plaque; GEO dataset; KYNU; bioinformation