Mapping the visual brain areas susceptible to phosphene induction through brain stimulation.
Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique whose effects on neural activity can be uncertain. Within the visual cortex, phosphenes are a useful marker of TMS: They indicate the induction of neural activation that propagates and creates a conscious percept. However, we currently do not know how susceptible different areas of the visual cortex are to TMS-induced phosphenes. In this study, we systematically map out locations in the visual cortex where stimulation triggered phosphenes. We relate this to the retinotopic organization and the location of object- and motion-selective areas, identified by functional magnetic resonance imaging (fMRI) measurements. Our results show that TMS can reliably induce phosphenes in early (V1, V2d, and V2v) and dorsal (V3d and V3a) visual areas close to the interhemispheric cleft. However, phosphenes are less likely in more lateral locations (hMT+/V5 and LOC). This suggests that early and dorsal visual areas are particularly amenable to TMS and that TMS can be used to probe the functional role of these areas.
Department of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.
Lukas F
LF
Schaeffner
Department of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK. aew69@cam.ac.uk.
Andrew E
0000-0002-7559-3299
AE
Welchman
D000328:Adult; D001931:Brain Mapping; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008297:Male; D038361:Neuronavigation; D010100:Oxygen / Q000097:blood; D010719:Phosphenes / Q000502:physiology*; D010775:Photic Stimulation; D011601:Psychophysics; D050781:Transcranial Magnetic Stimulation; D014793:Visual Cortex / Q000000981:diagnostic imaging / Q000502:physiology*; D014795:Visual Pathways / Q000000981:diagnostic imaging / Q000502:physiology*; D055815:Young Adult
D010100:Oxygen
Brain stimulation marker; Cortical excitability; Stimulation efficacy; Transcranial magnetic stimulation
PLoS Biol. 2005 Jul;3(7):e204
15934786
Cereb Cortex. 1991 Jan-Feb;1(1):1-47
1822724
J Cogn Neurosci. 2003 Oct 1;15(7):948-60
14614806
Handb Clin Neurol. 2013;116:655-69
24112931
Neuroimage. 2013 Nov 1;81:253-64
23644000
Hum Brain Mapp. 2012 Mar;33(3):652-65
21416561
Cereb Cortex. 2014 Jan;24(1):17-36
23010748
Cortex. 2009 Oct;45(9):1025-34
19027896
Curr Opin Neurobiol. 2000 Apr;10(2):232-7
10753803
Electroencephalogr Clin Neurophysiol. 1998 Jan;108(1):1-16
9474057
J Neuroeng Rehabil. 2015 May 17;12:47
25981522
Cereb Cortex. 2014 Oct;24(10):2751-60
23696280
J Neurosci. 1991 Mar;11(3):641-9
2002358
Clin Neurophysiol. 2009 Dec;120(12):2008-39
19833552
J Neurophysiol. 2013 Jan;109(2):437-44
23114213
Neuroimage. 2007 Jun;36(2):313-21
17442592
Neuroreport. 2000 Sep 28;11(14):3269-73
11043562
J Neurophysiol. 2005 Dec;94(6):4520-7
16135552
J Vis Exp. 2010 Dec 28;(46):null
21248686
J Cogn Neurosci. 2009 Feb;21(2):207-21
18823235
J Neurosci Methods. 2012 Mar 15;204(2):238-41
22138632
Suppl Clin Neurophysiol. 2003;56:305-11
14677407
J Neurosci. 2007 Apr 11;27(15):4178-81
17428995
Neuroimage. 2013 Feb 1;66:531-42
23116812
Neuron. 2007 Oct 25;56(2):366-83
17964252
Neuroimage. 2005 May 15;26(1):18-28
15862201
Neuroreport. 2004 Feb 9;15(2):297-302
15076756
Neuropsychologia. 1999 Feb;37(2):191-8
10080376
Cereb Cortex. 2016 Sep;26(9):3719-31
26271111
Neuroimage. 2011 Jun 1;56(3):1426-36
21376818
Brain. 2002 Mar;125(Pt 3):479-90
11872606
PLoS One. 2011;6(7):e22342
21799833
Hum Brain Mapp. 2011 Mar;32(3):341-57
20533563
Clin Neurophysiol. 2010 Mar;121(3):376-9
20079689
Trends Cogn Sci. 2015 Jan;19(1):13-20
25467129
J Vis Exp. 2010 Apr 01;(38):null
20360672
PLoS One. 2011;6(11):e27204
22087266
Neurosci Biobehav Rev. 2011 Jan;35(3):871-7
20955732
Optom Vis Sci. 1994 May;71(5):301-11
8065706
Hum Brain Mapp. 2013 Apr;34(4):923-35
22109746
Exp Brain Res. 2005 Jan;160(1):129-40
15368087
Ann N Y Acad Sci. 2011 Sep;1233:200-7
21950994
Hum Brain Mapp. 2002 Nov;17(3):143-55
12391568
J Neurol Sci. 2003 Nov 15;215(1-2):75-8
14568132
Neurosci Biobehav Rev. 2011 Jan;35(3):516-36
20599555
Clin Neurophysiol. 2001 Feb;112(2):250-8
11165526
Science. 2001 Apr 20;292(5516):510-2
11313497
Vis Neurosci. 2015 Jan;32:E014
26241035
Clin Neurophysiol. 2002 Sep;113(9):1501-4
12169333
Phys Med Biol. 2014 Jan 6;59(1):203-18
24334481
Electroencephalogr Clin Neurophysiol. 1992 Feb;85(1):9-16
1371748
Neuroimage. 2001 Aug;14(2):329-46
11467907
Electroencephalogr Clin Neurophysiol. 1992 Feb;85(1):17-21
1371739
Front Psychol. 2014 Sep 23;5:1019
25295015
J Clin Neurophysiol. 1998 Jul;15(4):351-7
9736469
Clin Neurophysiol. 2001 Nov;112(11):2015-21
11682339
Hum Brain Mapp. 2010 Sep;31(9):1408-17
20091790
Open Neuroimag J. 2010;4:100-10
21686319