The national landscape of human papillomavirus-associated oropharynx squamous cell carcinoma.
The head and neck squamous cell carcinoma (HNC) landscape is evolving with human papillomavirus (HPV) being a rising cause of oropharynx carcinoma (OPC). This study seeks to investigate a national database for HPV-associated oropharynx carcinoma (HPV-OPC). Using the National Cancer Data Base, we analyzed 22,693 patients with HPV-OPC and known HPV status. Chi-square tests and logistic regression models were utilized to examine differences between HPV positive and HPV negative OPC. 14,805 (65.2%) patients were HPV positive. Mean age at presentation was 58.4 years with HPV-HNC patients being 2.8 years younger compared to the HPV-negative cohort (58.4 vs. 61.2 years, p < 0.001). 67.6% of white patients were HPV-positive compared to 42.3% of African American patients and 57.1% of Hispanics (p < 0.001). When combining race and socioeconomic status (SES), we found African American patients in high SES groups had HPV-OPC prevalence that was significantly higher than African American patients in low SES groups (56.9% vs. 36.3%, p < 0.001). Geographic distribution of HPV-OPC was also analyzed and found to be most prevalent in Western states and least prevalent in the Southern states (p < 0.001). The distribution of HPV-OPC is variable across the country and among racial and socioeconomic groups. A broad understanding of these differences in HPV-OPC should drive educational programs and improve clinical trials that benefit both prevention and current treatments.
Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, NorthShore University HealthSystem, Evanston, IL.
Erik
E
Liederbach
Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, NorthShore University HealthSystem, Evanston, IL.
Alexandra
A
Kyrillos
Center for Biomedical Research Informatics, NorthShore University HealthSystem, Evanston, IL.
Chi-Hsiung
CH
Wang
Department of Otolaryngology, Temple University School of Medicine, Philadelphia, PA.
Jeffrey C
JC
Liu
Department of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, TX.
Erich M
EM
Sturgis
Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, NorthShore University HealthSystem, Evanston, IL.|Pritzker School of Medicine, University of Chicago, Chicago, IL.
Mihir K
MK
Bhayani
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000821:virology*; D005260:Female; D006258:Head and Neck Neoplasms / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000453:epidemiology* / Q000821:virology*; D009960:Oropharynx / Q000473:pathology / Q000821:virology; D027383:Papillomaviridae / Q000472:pathogenicity*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology; D015995:Prevalence; D044469:Racial Groups
National Cancer Data Base; head and neck cancer; human papillomavirus; oropharynx; squamous cell carcinoma