Data on the histological and immune cell response in the popliteal lymph node in mice following exposure to metal particles and ions.
Hip implants containing cobalt-chromium (CoCr) have been used for over 80 years. In patients with metal-on-metal (MoM) hip implants, it has been suggested that wear debris particles may contribute to metal sensitization in some individuals, leading to adverse reactions. This article presents data from a study in which the popliteal lymph node assay (PLNA) was used to assess immune responses in mice treated with chromium-oxide (Cr2O3) particles, metal salts (CoCl2, CrCl3, and NiCl2) or Cr2O3 particles with metal salts ("A preliminary evaluation of immune stimulation following exposure to metal particles and ions using the mouse popliteal lymph node assay" (B.E. Tvermoes, K.M. Unice, B. Winans, M. Kovochich, E.S. Fung, W.V. Christian, E. Donovan, B.L. Finley, B.L. Kimber, I. Kimber, D.J. Paustenbach, 2016) [1]). Data are presented on (1) the chemical characterization of TiO2 particles (used as a particle control), (2) clinical observations in mice treated with Cr2O3 particles, metal salts or Cr2O3 particles with metal salts, (3) PLN weight and weight index (WI) in mice treated with Cr2O3 particles, metal salts or Cr2O3 particles with metal salts, (4) histological changes in PLNs of mice treated with Cr2O3 particles, metal salts or Cr2O3 particles with metal salts, (5) percentages of immune cells in the PLNs of mice treated with Cr2O3 particles, metal salts or Cr2O3 particles with metal salts, and (6) percentages of proliferating cells in the PLNs of mice treated with Cr2O3 particles, metal salts or Cr2O3 particles with metal salts.
Cardno ChemRisk, LLC.; 101 2nd Street, Suite 700, San Francisco, CA 94105, USA.
Bethany
B
Winans
Cardno ChemRisk, LLC.; 4940 Pearl East Circle, Suite 100, Boulder, CO 80301, USA.
Brooke E
BE
Tvermoes
Cardno ChemRisk, LLC.; 20 Stanwix Street, Suite 505, Pittsburgh, PA 15222, USA.
Kenneth M
KM
Unice
Cardno ChemRisk, LLC.; 130 Vantis Drive, Suite 170, Aliso Viejo, CA 92656, USA.
Michael
M
Kovochich
Cardno ChemRisk, LLC.; 130 Vantis Drive, Suite 170, Aliso Viejo, CA 92656, USA.
Ernest S
ES
Fung
Cardno ChemRisk, LLC.; 20 Stanwix Street, Suite 505, Pittsburgh, PA 15222, USA.
Whitney V
WV
Christian
Cardno ChemRisk, LLC.; 101 2nd Street, Suite 700, San Francisco, CA 94105, USA.
Ellen
E
Donovan
Cardno ChemRisk, LLC.; 101 2nd Street, Suite 700, San Francisco, CA 94105, USA.
Brent L
BL
Finley
University of Manchester, Faculty of Life Sciences, Oxford Road, Manchester M13 9PT, UK.
Ian
I
Kimber
Cardno ChemRisk, LLC.; 101 2nd Street, Suite 700, San Francisco, CA 94105, USA.
Dennis J
DJ
Paustenbach
Hypersensitivity; Immune stimulation; Lymph node cell activation; Metal-on-metal implants; Metals; Particles; Popliteal lymph node assay
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