Periodontal manifestations of inflammatory bowel disease: emerging epidemiologic and biologic evidence.
Inflammatory bowel disease and periodontitis are both described as a disproportionate mucosal inflammatory response to a microbial environment in susceptible patients. Moreover, these two conditions share major environmental and lifestyle-related risk factors. Despite this intriguing pathogenic parallel, large-scale studies and basic research have only recently considered periodontal outcomes as relevant data. There are mounting and consistent arguments, from recent epidemiologic studies and animal models, that these two conditions might be related. This article is a comprehensive and critical up-to-date review of the current evidence and future prospects in understanding the biologic and epidemiologic relationships between periodontal status and inflammatory bowel disease.
Univ. Lille, Inserm, CHU Lille, U1008 - Controlled Drug Delivery Systems and Biomaterials, Lille, France.|Department of Periodontology, School of Dentistry, University of Lille, Lille, France.
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http://orcid.org/0000-0003-4305-1353
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Agossa
Univ. Lille, Inserm, CHU Lille, U995 - LIRIC - Lille Inflammation Research International Center, Lille, France.
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Dendooven
Univ. Lille, Inserm, CHU Lille, U995 - LIRIC - Lille Inflammation Research International Center, Lille, France.
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Dubuquoy
Univ. Lille, Inserm, CHU Lille, U995 - LIRIC - Lille Inflammation Research International Center, Lille, France.|Public Health, Epidemiology and Economic Health, Registre Epimad, Maison Régionale de la Recherche Clinique, Centre Hospitalier Universitaire Régional, Lille Cedex, France.
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Gower-Rousseau
Univ. Lille, Inserm, CHU Lille, U1008 - Controlled Drug Delivery Systems and Biomaterials, Lille, France.|Department of Periodontology, School of Dentistry, University of Lille, Lille, France.
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Delcourt-Debruyne
Univ. Lille, Inserm, CHU Lille, U995 - LIRIC - Lille Inflammation Research International Center, Lille, France.
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Capron
D000818:Animals; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D010510:Periodontal Diseases / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D010518:Periodontitis / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D010519:Periodontium / Q000473:pathology
Crohn's disease; inflammatory bowel disease; periodontal diseases; periodontitis