IL6-174 G>C Polymorphism (rs1800795) Association with Late Effects of Low Dose Radiation Exposure in the Portuguese Tinea Capitis Cohort.
Head and neck cancers, and cardiovascular disease have been described as late effects of low dose radiation (LDR) exposure, namely in tinea capitis cohorts. In addition to radiation dose, gender and younger age at exposure, the genetic background might be involved in the susceptibility to LDR late effects. The -174 G>C (rs1800795) SNP in IL6 has been associated with cancer and cardiovascular disease, nevertheless this association is still controversial. We assessed the association of the IL6-174 G>C SNP with LDR effects such as thyroid carcinoma, basal cell carcinoma and carotid atherosclerosis in the Portuguese tinea capitis cohort. The IL6-174 G>C SNP was genotyped in 1269 individuals formerly irradiated for tinea capitis. This sampling group included thyroid cancer (n = 36), basal cell carcinoma (n = 113) and cases without thyroid or basal cell carcinoma (1120). A subgroup was assessed for atherosclerosis by ultrasonography (n = 379) and included matched controls (n = 222). Genotypes were discriminated by real-time PCR using a TaqMan SNP genotyping assay. In the irradiated group, we observed that the CC genotype was significantly associated with carotid plaque risk, both in the genotypic (OR = 3.57, CI = 1.60-7.95, p-value = 0.002) and in the recessive (OR = 3.02, CI = 1.42-6.42, p-value = 0.004) models. Irradiation alone was not a risk factor for carotid atherosclerosis. We did not find a significant association of the IL6-174 C allele with thyroid carcinoma or basal cell carcinoma risk. The IL6-174 CC genotype confers a three-fold risk for carotid atherosclerotic disease suggesting it may represent a genetic susceptibility factor in the LDR context.
IPATIMUP-Institute of Molecular Pathology and Immunology of the University of Porto, Rua Júlio Amaral de Carvalho 45, 4200-135 Porto, Portugal.|i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.
Paula
P
Boaventura
IPATIMUP-Institute of Molecular Pathology and Immunology of the University of Porto, Rua Júlio Amaral de Carvalho 45, 4200-135 Porto, Portugal.|i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.
Cecília
C
Durães
IPATIMUP-Institute of Molecular Pathology and Immunology of the University of Porto, Rua Júlio Amaral de Carvalho 45, 4200-135 Porto, Portugal.|i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.
Adélia
A
Mendes
IPATIMUP-Institute of Molecular Pathology and Immunology of the University of Porto, Rua Júlio Amaral de Carvalho 45, 4200-135 Porto, Portugal.|i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.
Natália Rios
NR
Costa
Hospital of S. João, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal.
Inês
I
Chora
Hospital of S. João, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal.
Sara
S
Ferreira
Hospital of S. João, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal.
Emanuel
E
Araújo
Hospital of S. João, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal.
Pedro
P
Lopes
Hospital of S. João, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal.
Gilberto
G
Rosa
Hospital of S. João, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal.
Pedro
P
Marques
Hospital of S. João, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal.|Faculty of Medicine of the University of Porto, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal.
Paulo
P
Bettencourt
Hospital of S. João, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal.
Inês
I
Oliveira
Hospital of S. João, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal.
Francisco
F
Costa
Hospital of S. João, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal.|Faculty of Medicine of the University of Porto, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal.
Isabel
I
Ramos
Hospital of S. João, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal.|Faculty of Medicine of the University of Porto, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal.
Maria José
MJ
Teles
Hospital of S. João, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal.|Faculty of Medicine of the University of Porto, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal.
João Tiago
JT
Guimarães
IPATIMUP-Institute of Molecular Pathology and Immunology of the University of Porto, Rua Júlio Amaral de Carvalho 45, 4200-135 Porto, Portugal.|i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.|Hospital of S. João, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal.|Faculty of Medicine of the University of Porto, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal.
Manuel
M
Sobrinho-Simões
IPATIMUP-Institute of Molecular Pathology and Immunology of the University of Porto, Rua Júlio Amaral de Carvalho 45, 4200-135 Porto, Portugal.|i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.|Faculty of Medicine of the University of Porto, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal.
Paula
P
Soares
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