The Chromatin Landscape of Cellular Senescence.
Cellular senescence, an irreversible growth arrest triggered by a variety of stressors, plays important roles in normal physiology and tumor suppression, but accumulation of senescent cells with age contributes to the functional decline of tissues. Senescent cells undergo dramatic alterations to their chromatin landscape that affect genome accessibility and their transcriptional program. These include the loss of DNA-nuclear lamina interactions, the distension of centromeres, and changes in chromatin composition that can lead to the activation of retrotransposons. Here we discuss these findings, as well as recent advances in microscopy and genomics that have revealed the importance of the higher-order spatial organization of the genome in defining and maintaining the senescent state.
Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912, USA.
Steven W
SW
Criscione
Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912, USA.
Yee Voan
YV
Teo
Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912, USA; Center for Computational Molecular Biology, Brown University, Providence, RI 02912, USA. Electronic address: nicola_neretti@brown.edu.
Nicola
N
Neretti
D016922:Cellular Senescence / Q000235:genetics*; D002503:Centromere / Q000235:genetics; D002843:Chromatin / Q000235:genetics*; D004247:DNA / Q000235:genetics; D023281:Genomics; D006570:Heterochromatin / Q000235:genetics; D006657:Histones / Q000235:genetics; D006801:Humans; D034881:Nuclear Lamina / Q000235:genetics; D014158:Transcription, Genetic
D002843:Chromatin; D006570:Heterochromatin; D006657:Histones; D004247:DNA
DNA damage; Hi-C; aging; cellular senescence; chromatin; chromosome structure
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