Dissolution Dynamic Nuclear Polarization capability study with fluid path.
Signal enhancement by hyperpolarization is a way of overcoming the low sensitivity in magnetic resonance; MRI in particular. One of the most well-known methods, dissolution Dynamic Nuclear Polarization, has been used clinically in cancer patients. One way of ensuring a low bioburden of the hyperpolarized product is by use of a closed fluid path that constitutes a barrier to contamination. The fluid path can be filled with the pharmaceuticals, i.e. imaging agent and solvents, in a clean room, and then stored or immediately used at the polarizer. In this study, we present a method of filling the fluid path that allows it to be reused. The filling method has been investigated in terms of reproducibility at two extrema, high dose for patient use and low dose for rodent studies, using [1-13C]pyruvate as example. We demonstrate that the filling method allows high reproducibility of six quality control parameters with standard deviations 3-10 times smaller than the acceptance criteria intervals in clinical studies.
Department of Electrical Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark.
Ronja M
RM
Malinowski
Department of Electrical Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark.
Kasper W
KW
Lipsø
Department of Electrical Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark; Albeda Research, Ole Maaloes vej 3, 2200 København N, Denmark.
Mathilde H
MH
Lerche
Department of Electrical Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark; GE Healthcare, Denmark. Electronic address: jhar@elektro.dtu.dk.
Jan H
JH
Ardenkjær-Larsen
Dissolution-DNP; Dynamic Nuclear Polarization; Hyperpolarization; Polarizer