Association of CD14 -159 (-260C/T) polymorphism and asthma risk: an updated genetic meta-analysis study.
BACKGROUND
It has been reported that the cluster of differentiation 14 (CD14) gene -159C/T variant may be associated with asthma risk. However, some studies yielded conflicting results. Therefore, a comprehensive meta-analysis was designed to assess the precise association.


METHODS
A systematic search in PubMed, Embase (Ovid), China National Knowledge Internet (CNKI), and Wan fang databases was conducted up to August 15, 2015. Odds ratio (OR) and 95% confidence interval (CI) were used to pool the effect size. We used I to assess heterogeneity, and a funnel plot and Egger test to assess publication bias.


RESULTS
In total, 34 studies involving 15,641 subjects were included in this meta-analysis. There was a statistically significant association between CD14 -159C/T polymorphism and asthma risk observed in dominant model (TT+TC vs CC: OR = 0.86, 95% CI = 0.77-0.97, P = 0.012) and codominant model (TC vs CC: OR = 0.88, 95% CI = 0.78-0.99, P = 0.035) in adults. However, there may be no significant association between CD14 159C/T and atopic and nonatopic asthma risk.


CONCLUSIONS
In summary, the overall results suggested that the CD14 -159C/T variant may decrease the risk of asthma susceptibility in adults. However, no significant association between CD14 159C/T and atopic and nonatopic asthma susceptibility was identified. More studies with larger sample size are needed to validate the findings from this study.
aWest China Hospital/West China School of Medicine bState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu cTianjin Hospital, Tianjin dDepartment of Orthopedics, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China.
Duan
D
Wang
Yang
Y
Yang
Jin
J
Xu
Zong-Ke
ZK
Zhou
Hai-Yang
HY
Yu
D000328:Adult; D001249:Asthma / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000235:genetics; D018950:Lipopolysaccharide Receptors / Q000235:genetics*; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012307:Risk Factors
D018950:Lipopolysaccharide Receptors
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