Synthesis of Nitrogen Heterocycles via Photochemical Ring Opening of Pyridazine N-Oxides.
A photochemical method for the direct synthesis of 1H-pyrazoles from pyridazine N-oxides was developed. This chemistry features a regioselective approach to nonsymmetrically substituted pyridazine N-oxides. Herein, we highlight the first strategic use of photoinduced ring-opening reactions of 1,2-diazine N-oxides for the preparative synthesis of nitrogen heterocycles.
Department of Chemistry and Biochemistry, Florida State University , Tallahassee, Florida 32306, United States.
Maribel
M
Portillo
Department of Chemistry and Biochemistry, Florida State University , Tallahassee, Florida 32306, United States.
Michael A
MA
Maxwell
Department of Chemistry and Biochemistry, Florida State University , Tallahassee, Florida 32306, United States.
James H
JH
Frederich