Postnatal cytomegalovirus infection in an infant with congenital thrombocytopenia: how it can support or mislead the diagnosis of Wiskott-Aldrich syndrome.
A male newborn developed a post-natal cytomegalovirus (CMV) infection, arising in the clinical setting of congenital thrombocytopenia, which was diagnosed as being alloimmune. The evidence of active CMV infection in an infant showing slow-resolution lower airways infection, persistent neonatal and low platelet volume thrombocytopenia, and diffuse eczema (associated to very high levels of serum immunoglobulin E) led to the diagnosis of Wiskott-Aldrich syndrome (WAS) before the third month of life, despite the presence of several confounding clinical factors. The correct interpretation of all clinical features supported the precocious diagnosis of WAS.
Department of Paediatrics, Azienda Ospedaliera di Melegnano, Milan, Italy.
Dimitri
D
Poddighe
1Department of Paediatrics, Azienda Ospedaliera di Melegnano, Milan, Italy 2Department of Paediatrics, Spedali Civili di Brescia, Brescia, Italy.
Elena
E
Virginia
Department of Paediatrics, Azienda Ospedaliera di Melegnano, Milan, Italy.
Marco
M
Nedbal
Department of Paediatrics, Spedali Civili di Brescia, Brescia, Italy.
Annarosa
A
Soresina
Department of Paediatrics, Azienda Ospedaliera di Melegnano, Milan, Italy.
Paola
P
Bruni
D000328:Adult; D003586:Cytomegalovirus Infections / Q000209:etiology* / Q000276:immunology; D042241:Early Diagnosis; D004485:Eczema / Q000209:etiology; D005260:Female; D005966:Glucuronidase / Q000276:immunology; D006801:Humans; D006942:Hypergammaglobulinemia / Q000209:etiology*; D007112:Immunity, Maternally-Acquired; D016867:Immunocompromised Host; D007073:Immunoglobulin E / Q000097:blood*; D007223:Infant; D008297:Male; D016269:Milk Hypersensitivity / Q000150:complications; D054098:Thrombocytopenia, Neonatal Alloimmune / Q000209:etiology* / Q000276:immunology; D014923:Wiskott-Aldrich Syndrome / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D000099175:Heparanase
D005966:Glucuronidase; D007073:Immunoglobulin E; D000099175:Heparanase