Technical standardization of Kasai portoenterostomy for biliary atresia.
BACKGROUND
The purpose of this study was to assess the clinical outcome of patients treated with the current technique of Kasai procedure compared with that of those treated with previous procedures.


METHODS
We retrospectively assessed the outcomes of 256 patients with biliary atresia who underwent Kasai portoenterostomy at our hospital between 1972 and 2014. Patients were divided into four groups: group 1 (1972-1981, double Roux-en Y, n=91), group 2 (1982-1991, Suruga II, n=80), group 3 (1992-2000, double-valve Roux-en Y, n=46), and group 4 (2001-2014, total removal of the extrahepatic biliary remnants at hepatic capsule and Roux-en Y reconstruction with a spur valve, n=39). Clinical outcomes were compared between the four groups.


RESULTS
In groups 1, 2, 3, and 4, the rate of jaundice clearance was 65.9%, 77.5%, 63.0%, and 87.2%, respectively; incidence of early cholangitis was 60.4%, 53.8%, 37.0%, and 23.1%, respectively; requirement for redo Kasai surgery was 15.4%, 37.5%, 17.4%, and 5.1%, respectively; 10-year native liver survival rate was 53.8%, 60.1%, 44.1%, and 73.7%, respectively; and 10-year overall survival rate was 55.0%, 72.3%, 86.7%, and 97.3%, respectively.


CONCLUSIONS
The standardized Kasai procedure was associated with favorable outcomes. Long-term outcomes remain to be evaluated.


METHODS
Case-control/treatment study, level III.
Department of Pediatric Surgery, Tohoku University Graduate School of Medicine. Electronic address: mnio@ped-surg.med.tohoku.ac.jp.
Masaki
M
Nio
Department of Pediatric Surgery, Tohoku University Graduate School of Medicine.
Motoshi
M
Wada
Department of Pediatric Surgery, Tohoku University Graduate School of Medicine.
Hideyuki
H
Sasaki
Department of Pediatric Surgery, Tohoku University Graduate School of Medicine.
Takuro
T
Kazama
Department of Pediatric Surgery, Tohoku University Graduate School of Medicine.
Hiromu
H
Tanaka
Department of Pediatric Surgery, Tohoku University Graduate School of Medicine.
Hironori
H
Kudo
D001656:Biliary Atresia / Q000401:mortality / Q000601:surgery*; D005260:Female; D006801:Humans; D007223:Infant; D007564:Japan / Q000453:epidemiology; D008099:Liver / Q000601:surgery*; D008297:Male; D011171:Portoenterostomy, Hepatic / Q000379:methods / Q000592:standards*; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D016896:Treatment Outcome
Biliary atresia; Cholangitis; Jaundice clearance; Kasai portoenterostomy; Long-term outcome