Serum level of scorpion toxins, electrolytes and electrocardiogram alterations in Mexican children envenomed by scorpion sting.
The scorpion Centruroides limpidus limpidus (C.l.l.) is endemic in México, producing hundreds of accidents in humans; children being one of the most susceptible targets. Few studies reported that severe envenoming by scorpion venom induces cardiac damage and electrolytes abnormalities in children, but the relationship of envenoming severity and toxic blood levels is unknown. The aim of this study was to determine the relationship among clinical status of envenoming, serum electrolyte, electrocardiographic abnormalities, and serum toxin levels in 44 children stung by scorpion over a period of 6 months in the State of Morelos, Mexico. The patients were said to be asymptomatic, when they presented just local symptoms, and were said to be symptomatic when showing local symptoms and at least one systemic symptom. The clinical status was evaluated at the admission at the emergency room of the Hospital, and 30 min after the administration of polyspecific F(ab')2 anti-scorpion therapy to symptomatic children. Forty-one percent of the children were asymptomatic and 59% symptomatic. Potassium and sodium imbalance and an elongation of the QT interval were detected; the rate of hypokalemia was higher in symptomatic than on asymptomatic children (50% and 6%, respectively). Hypokalemia persisted in 19% in symptomatic patients, whereas sodium reached normal levels 30 min after anti-venom therapy. The hypokalemia statistically correlated with elongation of the QT interval. The concentration of the toxic components of C.l.l in serum was significantly higher in symptomatic than asymptomatic children, and the serum levels of the toxic component significantly decreased to undetectable levels after the application of anti-venom therapy. Despite the small size of the sample, this study establishes that severity of envenoming was statistically related to potassium imbalance in serum, QT interval and the concentration of toxic components in serum, which decreased at undetectable levels after specific treatment with the anti-scorpion venom, correlating with clinical disappearance or greatly reduction of symptoms of envenomation.
Instituto Nacional de Pediatría, Ciudad de México, Mexico; Hospital Del Niño Morelense, Cuernavaca, Morelos, Mexico.
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Osnaya-Romero
Departamento de Toxicología, Centro de Investigación y Estudios Avanzados, IPN, Ciudad de México, Mexico.
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Acosta-Saavedra
Facultad de Medicina, Universidad Juárez del Estado de Durango, Gómez Palacio, Durango, Mexico.
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Goytia-Acevedo
Instituto Politécnico Nacional (IPN), Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional, Unidad Durango, Durango, Mexico.
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Lares-Asseff
Hospital Del Niño Morelense, Cuernavaca, Morelos, Mexico.
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Basurto-Celaya
Instituto Nacional de Pediatría, Ciudad de México, Mexico.
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Perez-Guille
Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico.
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Possani
Departamento de Toxicología, Centro de Investigación y Estudios Avanzados, IPN, Ciudad de México, Mexico. Electronic address: scalder@cinvestav.mx.
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Calderón-Aranda
D000293:Adolescent; D000818:Animals; D001733:Bites and Stings; D002648:Child; D004562:Electrocardiography; D004573:Electrolytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008800:Mexico; D012604:Scorpion Venoms / Q000378:metabolism*; D012605:Scorpions
D004573:Electrolytes; D012604:Scorpion Venoms
Centruroides limpidus limpidus; Children envenoming; Hypokalemia; QT elongation; Scorpion toxin level