Polymorphisms in Toll-like receptor 3 are associated with asthma-related phenotypes in the Chinese Han patients.
Toll-like receptor (TLR) 3 mediates antivirus immunity and is involved in asthma exacerbation and development. However, the genetic association between TLR3 and asthma remains unclear. This study aimed to evaluate the effects of polymorphisms within TLR3 on asthma risk and asthma-related phenotypes in the Chinese Han population. A total number of 462 unrelated adult patients with asthma and 398 healthy volunteers were enrolled in this study. The genotypes of tagging single nucleotide polymorphisms (SNPs) in TLR3 gene were determined using multiplex SNaPshot SNP genotyping assays. Case-control and case-only studies were used to assess any links with asthma and asthma-related phenotypes. The results showed that the genetic variants in TLR3 were associated with asthma-related phenotypes, including eosinophil counts, serum immunoglobulin E levels and lung function. However, there was no obvious association between the TLR3 SNPs and asthma susceptibility or asthma severity. TLR3 polymorphisms may play a considerable role in the pathogenesis of asthma. It will help in better understanding the pathogenesis of asthma and development of more effective strategies for the prevention, prediction and treatment of asthma.
Department of Respiratory Medicine, Affiliated Changzhou No. 2 People's Hospital, Nanjing Medical University, Changzhou, China.|Department of Respiratory Medicine, Nanjing General Hospital of Nanjing Military Command, Nanjing, China.
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Q
Zhang
Health Science Center, Jiangsu University, Zhenjiang, China.
X L
XL
Fu
Department of Respiratory Medicine, Affiliated Jiangbing Hospital, Jiangsu University, Zhenjiang, China.
F H
FH
Qian
Department of Respiratory Medicine, Affiliated Changzhou No. 2 People's Hospital, Nanjing Medical University, Changzhou, China.
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Q
Cao
Department of Respiratory Medicine, Affiliated Changzhou No. 2 People's Hospital, Nanjing Medical University, Changzhou, China.
Z D
ZD
Mao
Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
J L
JL
Bai
Department of Respiratory Medicine, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Q
Q
Du
Department of Respiratory Medicine, Nanjing General Hospital of Nanjing Military Command, Nanjing, China.
Y
Y
Shi
D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000097:blood / Q000235:genetics* / Q000473:pathology; D001772:Blood Cell Count; D002681:China; D004804:Eosinophils / Q000378:metabolism; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008168:Lung / Q000502:physiology; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D051196:Toll-Like Receptor 3 / Q000235:genetics*
C495344:TLR3 protein, human; D051196:Toll-Like Receptor 3; D007073:Immunoglobulin E