Relationship between vitamin D receptor gene polymorphisms, cardiovascular risk factors and adiponectin in a healthy young population.
To explore the association between VDR polymorphisms and several cardiovascular risk factors and adiponectin.



Three-hundred and sixty-nine healthy students were randomly selected. Five VDR polymorphisms were genotyped: BsmI rs1544410; Cdx2 rs11568820; ApaI rs7975232; TaqI rs731236 and FokI rs2228570. BMI, waist circumference (WC), blood pressure, lipid/glycemic profiles and adiponectin were assessed.



In men, BsmI, ApaI and TaqI were associated with BMI and WC (p < 0.05). FokI was associated with triglycerides and high-density lipoprotein levels (p = 0.0036; p = 0.005) whereas BsmI and Cdx2 were associated with adiponectin levels (p = 0.026; p = 0.048). Associations disappeared after BMI and WC adjustments. In women, ApaI was associated with systolic blood pressure (p = 0.02).



Our study demonstrated a gender-specific difference between VDR SNPs and various cardiovascular risk factors and adiponectin.
Laboratoire de Pharmacologie, Pharmacie clinique et Contrôle de Qualité des médicaments, Pôle Technologie- Santé (PTS), Faculty of Pharmacy, Saint-Joseph University, Beirut, Lebanon.
Aline
A
Hajj
Genetics Medical Unit, Faculty of Medicine, Saint-Joseph University, Beirut, Lebanon.
Rima
R
Chedid
Genetics Medical Unit, Faculty of Medicine, Saint-Joseph University, Beirut, Lebanon.|Faculty of Medicine, Saint-Joseph University, Beirut, Lebanon.
Eliane
E
Chouery
Genetics Medical Unit, Faculty of Medicine, Saint-Joseph University, Beirut, Lebanon.|Faculty of Medicine, Saint-Joseph University, Beirut, Lebanon.
André
A
Megarbané
Faculty of Medicine, Saint-Joseph University, Beirut, Lebanon.|Department of Endocrinology, Hotel-Dieu de France Hospital, Saint-Joseph University, Beirut, Lebanon.
Marie-Hélène
MH
Gannagé-Yared
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000209:etiology*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D020641:Polymorphism, Single Nucleotide; D018167:Receptors, Calcitriol / Q000235:genetics*; D012307:Risk Factors; D017422:Sequence Analysis, DNA; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood
C499918:ADIPOQ protein, human; D052242:Adiponectin; D008055:Lipids; D018167:Receptors, Calcitriol; C579457:VDR protein, human; D014807:Vitamin D; C104450:25-hydroxyvitamin D
VDR polymorphism; adiponectin; cardiovascular risk factors; healthy subjects; vitamin D