Toxicity mechanism of titanium dioxide and zinc oxide nanoparticles against food pathogens.
Food preservation is an important field of research. It extends the shelf life of major food products. Our current study is based on food preservation through TiO2and ZnO nanoparticles. TiO2and ZnO are biocompatible nanomaterial. The biocompatibility of the materials were established through toxicity studies on cell lines. Titanium dioxide and Zinc Oxide nanoparticle were synthesized by wet chemical process. They are characterized by X-Ray diffraction and TEM. The antibacterial activities of both the materials were analysed to ensure their effectiveness as food preservative against Salmonella typhi, Klebsiella pneumoniae and Shigella flexneri. The results indicates that TiO2and ZnO nanoparticle inhibits Salmonella, Klebsiella and Shigella. The mode of action is by the generation of ROS in cases of Salmonella, Klebsiella. Mode of action in Shigella is still unclear. It was also proved that TiO2and ZnO nanoparticle are biocompatible materials.
Department of Nanotechnology, SRM University, Kattankulathur, Tamil Nadu, India. Electronic address: gdevanandvenkatasubbu@gmail.com.
G Devanand
GD
Venkatasubbu
Department of Biotechnology, University of Madras, Chennai, Tamil Nadu, India.
R
R
Baskar
Department of Nanotechnology, SRM University, Kattankulathur, Tamil Nadu, India.
T
T
Anusuya
Crystal Growth Centre, Anna University, Chennai, Tamil Nadu, India.
C Arun
CA
Seshan
Centre for Food Technology, Anna University, Chennai, Tamil Nadu, India.
Ramachandran
R
Chelliah
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000633:toxicity; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D053938:DNA Fragmentation / Q000187:drug effects; D005516:Food Microbiology; D005520:Food Preservatives / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000235:genetics / Q000254:growth & development; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry / Q000633:toxicity / Q000648:ultrastructure; D017382:Reactive Oxygen Species / Q000737:chemistry / Q000378:metabolism; D012485:Salmonella typhi / Q000187:drug effects / Q000235:genetics / Q000254:growth & development; D012763:Shigella flexneri / Q000187:drug effects / Q000235:genetics / Q000254:growth & development; D014025:Titanium / Q000737:chemistry*; D014961:X-Ray Diffraction; D015034:Zinc Oxide / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D005520:Food Preservatives; D017382:Reactive Oxygen Species; C009495:titanium dioxide; D014025:Titanium; D015034:Zinc Oxide
Food pathogens; Klebsiella; Salmonella; Shigella flexneri; Titanium dioxide; Zinc oxide