The Influence of Different Nonsteroidal Anti-Inflammatory Drugs on Alveolar Bone in Rats: An Experimental Study.
OBJECTIVE
The aim of this study was to investigate the effect of dexketoprofen trometamol, meloxicam, diclofenac sodium on any untreated alveolar bone when they are used as drugs for another indication.


METHODS
Twenty eight male Spraque-Dawley rats were randomized into four groups as dexketoprofen trometamol (Group I), meloxicam (Group II), diclofenac sodium (Group III) and control group. Nonsteroidal anti-inflammatory drugs (NSAID) were administered after a fibula fracture for 10 days. Untreated alveolar bone was histopathologically examined for spongious bone density, osteoclastic density and osteoblastic density.


RESULTS
Spongious bone density was lower in study groups (Group I, group II and group III) than the control group (p<0.05). In contrast, the increase in osteoclastic density was observed in other groups apart from the control group (p<0.05). Osteoblastic density was evaluated and it was determined that group II and group III had lower results than the control group (p<0.05) but group I was equal to the control group.


CONCLUSIONS
This study showed that systemically administrated NSAIDs have the potential to affect untreated alveolar bone. This should also be considered in long term use of NSAIDs.
Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Dumlupinar University, Kutahya, Turkey .
Mujgan Gungor
MG
Hatipoglu
Department of Orthopaedic and Traumatology, Faculty of Medicine, Dumlupinar University, Kutahya. Turkey .
Sermet
S
Inal
Department of Urology, Medical Faculty, Faculty of Medicine, Dumlupinar University, Kutahya, Turkey .
Sahin
S
Kabay
Department of Biology, Faculty of Arts and Science, Dumlupinar University, Kutahya,Turkey..
Muhammet Kasim
MK
Cayci
Department of Pathology, Faculty of Medicine, Dumlupinar University, Kutahya, Turkey.
Ayşenur
A
Deger
Department of Medical Laboratory Techniques, Simav Vocational High School, Dumlupinar University, Kutahya, Turkey.
Halil Isa
HI
Kuru
Department of Department of Biochemistry, Faculty of Medicine, Dumlupinar University, Kutahya, Turkey.
Sayit
S
Altikat
Department of Pathology, Ministry of Health, Dumlupinar University, Kutahya Evliya Celebi Education and Research Hospital, Kutahya, Turkey.
Gizem
G
Akkas
Non-steroidal anti-inflammatory agents; bone remodeling; maxillary bone; osteoblast; osteoclast
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