Could tea polyphenols be beneficial for preventing the precocious puberty?
Precocious puberty which impacts children physically and psychologically has become one of the health problem over the world. However, the mechanism and preventive measures of precocious puberty is still not clear. Recent studies suggested that leptin may act as the 'permissive factor' to initiate the puberty by regulating gonadotrophin-releasing hormone secretion. Previous evidence from animal and human studies found that tea polyphenols can reduce serum leptin levels in vivo and inhibit the expression of leptin in adipose tissue. This article focus on whether tea polyphenols could delay the onset of puberty by reducing leptin levels. To verify the possibility of tea polyphenols on preventing precocious puberty, animal experiment can be used. Our hypothesis that tea polyphenols could prevent the precocious puberty may provide important potential way for the prevention and control of children precocious puberty.
Department of Nutrition, School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China.
Youmei
Y
Wu
Department of Nutrition, School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China.
Jialu
J
Wang
Department of Nutrition, School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China; Department of Clinical Nutrition, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.
Wei
W
Cai
Department of Nutrition, School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China; Department of Clinical Nutrition, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China. Electronic address: srachel@126.com.
Xiuhua
X
Shen
D000818:Animals; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D006801:Humans; D020738:Leptin / Q000097:blood / Q000737:chemistry; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D051379:Mice; D059808:Polyphenols / Q000737:chemistry*; D011629:Puberty, Precocious / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012741:Sexual Maturation; D013662:Tea / Q000737:chemistry*; D014621:Vagina / Q000187:drug effects
D020738:Leptin; D059808:Polyphenols; D013662:Tea; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone
Leptin; Precocious puberty; Tea polyphenols