Inositols in the Treatment of Insulin-Mediated Diseases.
A growing body of research is currently focused on the role of inositol isomers and in particular myo-inositol (MYO-INS) and D-chiroinositol (DCI) in the treatment of insulin resistance states. Both isomers have been shown to exert insulin-mimetic action and to lower postprandial glucose. Further, insulin resistance-related diseases were associated to derangements in inositol metabolism. Thus, the aim of this review is to provide current evidence on the potential benefits of inositol isomers (MYO-INS and DCI) in the treatment of disease associated to insulin resistance such as polycystic ovary syndrome (PCOS), gestational diabetes, and metabolic syndrome. Finally, molecular insights into inositol insulin-sensitizing effects will be covered focusing on the possible role of inositol glycans as insulin second messengers.
IOS and Coleman Medicina Futura Medical Center, Centro Direzionale, 80143 Naples, Italy.
Giovanna
G
Muscogiuri
Department of Obstetrics and Gynecology, Arcispedale Santa Maria Nuova-IRCCS, 42123 Reggio Emilia, Italy.
Stefano
S
Palomba
Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, 98125 Messina, Italy.
Antonio Simone
0000-0003-1543-2802
AS
Laganà
Endocrinology, Department of Sports Science and Wellness, "Parthenope" University of Naples, 80133 Naples, Italy; Fertility Techniques SSD, "S. Giovanni di Dio e Ruggi d'Aragona" University Hospital, CMSO (Centro Medico Specialistico Orio), 84131 Salerno, Italy.
Francesco
0000-0002-9127-5987
F
Orio
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