Lipase Processing of Complex Lipid Antigens.
Mycobacterium tuberculosis synthesizes a wide variety of complex lipids that can serve as antigens in immune recognition of the bacterium. In this issue of Cell Chemical Biology, Gilleron et al. (2016) identify key enzymes essential for lipid antigen processing, which is required for CD1b-restricted T cell activation.
Institute of Medical Microbiology, University of Zurich, Gloriastrasse 30/32, CH-8006 Zurich, Switzerland. Electronic address: psander@imm.uzh.ch.
Peter
P
Sander
Institute of Medical Microbiology, University of Zurich, Gloriastrasse 30/32, CH-8006 Zurich, Switzerland.
Katja
K
Becker
Institute of Medical Microbiology, University of Zurich, Gloriastrasse 30/32, CH-8006 Zurich, Switzerland.
Michael Dal
MD
Molin
D017951:Antigen Presentation; D000942:Antigens, Bacterial; D018949:Antigens, CD1; D008049:Lipase; D008055:Lipids; D009169:Mycobacterium tuberculosis; D013601:T-Lymphocytes
D000942:Antigens, Bacterial; D018949:Antigens, CD1; D008055:Lipids; D008049:Lipase; C075988:pancreatic lipase related protein 2