CD8-positive Mycosis Fungoides Masquerading as Pyoderma Gangrenosum.
Mycosis fungoides (MF), a primary cutaneous T-cell lymphoma, accounts for <1% of non-Hodgkin lymphomas. The diagnosis of classic MF is based on a constellation of typical clinical presentation, histopathology, immunohistochemistry, and T-cell monoclonality detected by molecular studies. Rarely, atypical clinical presentation may occur. The typical immunohistochemical phenotype is, CD2 +ve, CD3 +ve, CD5 +ve, CD4 +ve, and CD8 - ve. Here, we report a rare case of CD8 +ve MF in a 43-year-male patient who was clinically diagnosed as pyoderma gangrenosum initially. The atypical presentation and rarity of such case have prompted this report.
Department of Pathology, Medical College, Kolkata, West Bengal, India.
Maitrayee
M
Saha
Department of Pathology, Medical College, Kolkata, West Bengal, India.
Bhawna Bhutoria
BB
Jain
Department of Pathology, North Bengal Medical College, Darjeeling, West Bengal, India.
Sarbani
S
Chattopadhyay
Department of Dermatology Venereology and Leprology, Medical College, Kolkata, West Bengal, India.
Indrashis
I
Podder
CD8+; mycosis fungoides; pyoderma gangrenosum
Hautarzt. 2002 Feb;53(2):114-7
11963190
Am J Pathol. 1985 Jun;119(3):436-47
3893149
Acta Derm Venereol. 2007;87(2):176-7
17340032
J Am Acad Dermatol. 2014 Feb;70(2):205.e1-16; quiz 221-2
24438969
Semin Diagn Pathol. 1991 May;8(2):62-72
1871451
J Dermatol Case Rep. 2009 Aug 24;3(2):30-3
21886726
Indian Dermatol Online J. 2012 May;3(2):122-4
23130286
Crit Rev Oncol Hematol. 2008 Feb;65(2):172-82
17950613
Am J Surg Pathol. 1995 Dec;19(12):1423-30
7503364
Br J Dermatol. 2007 Jan;156(1):1-10
17199560
Am J Pathol. 1999 Aug;155(2):483-92
10433941