Function of membranous lysyl-tRNA synthetase and its implication for tumorigenesis.
Aminoacyl-tRNA synthetases (ARSs) are essential enzymes that conjugate specific amino acids to their cognate tRNAs for protein synthesis. Besides their catalytic activity, recent studies have uncovered many additional functions of these enzymes through their interactions with diverse cellular factors. Among human ARSs, cytosolic lysyl-tRNA synthetase (KRS) is often highly expressed in cancer cells and tissues, and facilitates cancer cell migration and invasion through the interaction with the 67kDa laminin receptor on the plasma membrane. Specific modulation of this interaction by small molecule inhibitors has revealed a new way to control metastasis. Here, we summarize the pro-metastatic functions of KRS and their patho-physiological implications.
College of Pharmacy, Korea University, Sejong 30019, Republic of Korea; Medicinal Bioconvergence Research Center, Seoul National University, Seoul 08826, Republic of Korea.
Ho Jeon
HJ
Young
Medicinal Bioconvergence Research Center, Seoul National University, Seoul 08826, Republic of Korea; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea. Electronic address: jwl@snu.ac.kr.
Jung Weon
JW
Lee
Medicinal Bioconvergence Research Center, Seoul National University, Seoul 08826, Republic of Korea; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
Sunghoon
S
Kim
D021581:Active Transport, Cell Nucleus; D000604:Amino Acyl-tRNA Synthetases / Q000737:chemistry / Q000378:metabolism; D055162:Biocatalysis; D063646:Carcinogenesis / Q000378:metabolism*; D002462:Cell Membrane / Q000201:enzymology; D002465:Cell Movement; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D008250:Lysine-tRNA Ligase / Q000737:chemistry* / Q000378:metabolism*; D008954:Models, Biological; D008958:Models, Molecular; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D054730:Protein Interaction Domains and Motifs; D017474:Receptors, Laminin / Q000737:chemistry / Q000378:metabolism
D017474:Receptors, Laminin; D000604:Amino Acyl-tRNA Synthetases; D008250:Lysine-tRNA Ligase
Anti-cancer drug; Cancer metastasis; Laminin receptor; Lysyl-tRNA synthetase; Membrane localization; Protein-protein interaction