Nuf and Rip11 requirement for polarity determinant recycling during Drosophila development.
A tight relationship between apico-basal polarity and trafficking is essential for epithelial physiology and tissue homeostasis. Recent studies have described how some Rab GTPases, key components of the intracellular traffic machinery, contribute to the establishment of cell polarity in vertebrates. We have demonstrated a novel connection between cell polarity and trafficking: in Drosophila epithelia, the apical determinant aPKC is recycled via Rab11-Nuf-recycling endosomes to maintain cell polarity. Furthermore, the phosphorylation of Nuf by aPKC allows aPKC to control the sub-cellular localization of Nuf and its own membrane accumulation. Here we review these data and show the different contribution of the 2 Drosophila Rab11 adaptor proteins, Nuf and Rip11, to the maintenance of Drosophila embryonic ectoderm polarity.
a CABD , CSIC/JA/UPO, Campus Universidad Pablo de Olavide , Sevilla , Spain.
Francisco J
0000-0002-4212-3944
FJ
Calero-Cuenca
a CABD , CSIC/JA/UPO, Campus Universidad Pablo de Olavide , Sevilla , Spain.
Sol
0000-0003-4731-8107
S
Sotillos
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D016764:Cell Polarity; D004330:Drosophila / Q000166:cytology* / Q000378:metabolism*; D029721:Drosophila Proteins / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism*
D048868:Adaptor Proteins, Signal Transducing; D029721:Drosophila Proteins; D008565:Membrane Proteins; D009687:Nuclear Proteins; C520715:Rip11 protein, Drosophila; C111662:nuf protein, Drosophila
Drosophila embryo; Rip11; aPKC; centrosomes; nuclear fallout; trafficking
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