DR3 regulation of apoptosis of naive T-lymphocytes in children with acute infectious mononucleosis.
Acute infectious mononucleosis (AIM) is a widespread viral disease that mostly affects children. Development of AIM is accompanied by a change in the ratio of immune cells. This is provided by means of different biological processes including the regulation of apoptosis of naive T-cells. One of the potential regulators of apoptosis of T-lymphocytes is a death receptor 3 (DR3). We have studied the role of DR3 in the regulation of apoptosis of naive CD4+(nTh) and CD8+(nCTL) T-cells in healthy children and children with AIM. In healthy children as well as in children with AIM, the activation of DR3 is accompanied by inhibition of apoptosis of nTh. In healthy children, the stimulation of DR3 resulted in the increase in apoptosis of nCTL. On the contrary, in children with AIM, the level of apoptosis of nCTL decreased after DR3 activation, which is a positive contribution to the antiviral immune response. In children with AIM, nCTL are characterized by reduced level of apoptosis as compared with healthy children. These results indicate that DR3 can be involved in the reduction of sensitivity of nCTL to apoptosis in children with AIM.
1 Blokhina Research Institute of Epidemiology and Microbiology , Nizhny Novgorod, Russia.
Elena Nikolaevna
EN
Filatova
1 Blokhina Research Institute of Epidemiology and Microbiology , Nizhny Novgorod, Russia.
Elena Viktorovna
EV
Anisenkova
1 Blokhina Research Institute of Epidemiology and Microbiology , Nizhny Novgorod, Russia.
Nataliya Borisovna
NB
Presnyakova
1 Blokhina Research Institute of Epidemiology and Microbiology , Nizhny Novgorod, Russia.|2 Nizhny Novgorod State Medical Academy , Nizhny Novgorod, Russia.
Oleg Vladimirovich
OV
Utkin
D000293:Adolescent; D017209:Apoptosis; D002648:Child; D005260:Female; D006801:Humans; D007244:Infectious Mononucleosis / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D053219:Receptors, Tumor Necrosis Factor, Member 25 / Q000235:genetics / Q000378:metabolism*; D013601:T-Lymphocytes / Q000166:cytology* / Q000378:metabolism
D053219:Receptors, Tumor Necrosis Factor, Member 25; C506033:TNFRSF25 protein, human
DR3; acute infectious mononucleosis; apoptosis; naive T-lymphocytes