HMDSO-plasma coated electrospun fibers of poly(cyclodextrin)s for antifungal dressings.
Electrospun mats containing cyclodextrin polymers (poly-αCD or poly-βCD) were developed to act as wound dressings showing tunable release rate of the antifungal agent fluconazole incorporated forming inclusion complexes. Poly-αCD and poly-βCD were prepared via cross-linking with epichlorohydrin (EPI) as water-soluble large molecular weight polymers. Then, polyCDs forming complexes with fluconazole were mixed with poly-(ε-caprolactone) (PCL) or poly(N-vinylpyrrolidone) (PVP) for electrospinning. Obtained bead-free fibers showed a random distribution, diameters in the 350-850nm range, and a variety of physical stability behaviors in aqueous environment. Mats were coated by hexamethyldisiloxane (HMDSO) plasma polymerization to create a hydrophobic layer that prevented rapid drug diffusion. HMDSO coating was evidenced by the Si content of mat surface (EDX analysis) and by the increase in the water contact angle (up to 130°). In physiological-mimicking medium, non-treated mats showed burst release of fluconazole, whereas HMDSO-coated mats sustained the release and delayed disintegration of PVP-based mats. Antifungal tests evidenced that both coated and non-coated mats efficiently inhibited the growth of Candida albicans.
Departamento de Farmacia y Tecnología Farmacéutica, R+DPharma Group (GI-1645), Facultad de Farmacia, and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15872 Santiago de Compostela, Spain.
Alejandro
A
Costoya
Instituto de Investigaciones en Ciencia y Tecnología de Materiales, Universidad Nacional de Mar del Plata-CONICET, Mar del Plata, Argentina.
Florencia Montini
FM
Ballarin
Servicio de Microbiología y Parasitología, Complejo Hospitalario Universitario de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Jose
J
Llovo
Departamento de Farmacia y Tecnología Farmacéutica, R+DPharma Group (GI-1645), Facultad de Farmacia, and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15872 Santiago de Compostela, Spain.
Angel
A
Concheiro
Instituto de Investigaciones en Ciencia y Tecnología de Materiales, Universidad Nacional de Mar del Plata-CONICET, Mar del Plata, Argentina.
Gustavo A
GA
Abraham
Departamento de Farmacia y Tecnología Farmacéutica, R+DPharma Group (GI-1645), Facultad de Farmacia, and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15872 Santiago de Compostela, Spain. Electronic address: carmen.alvarez.lorenzo@usc.es.
Carmen
C
Alvarez-Lorenzo
D000935:Antifungal Agents / Q000008:administration & dosage / Q000737:chemistry*; D001458:Bandages; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development; D002482:Cellulose / Q000008:administration & dosage / Q000737:chemistry*; D003505:Cyclodextrins / Q000008:administration & dosage / Q000737:chemistry*; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry*; D065546:Drug Liberation; D015725:Fluconazole / Q000008:administration & dosage / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D011760:Pyrrolidinones / Q000008:administration & dosage / Q000737:chemistry; D012833:Siloxanes / Q000008:administration & dosage / Q000737:chemistry*; D013678:Technology, Pharmaceutical
D000935:Antifungal Agents; D003505:Cyclodextrins; D004337:Drug Carriers; D011760:Pyrrolidinones; D012833:Siloxanes; C041953:cyclodextrin polymer; C042670:N-vinyl-2-pyrrolidinone; D015725:Fluconazole; D002482:Cellulose; C015917:hexamethyldisiloxane
Antifungal activity; Cyclodextrin polymers; Electrospinning; Fluconazole; HMDSO coating; Plasma polymerization