Cannabisol, a novel Δ9-THC dimer possessing a unique methylene bridge, isolated fromCannabis sativa.
Cannabisol (1), a unique dimer of Δ9-tetrahydrocannabinol (Δ9-THC) with a methylene bridge, was isolated fromCannabis sativa. This is the first example of a C-bridged dimeric cannabinoid. The structure of1was unambiguously deduced by HRESIMS, GCMS, and NMR spectroscopy. A plausible biogenesis of1is described.
National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University MS 38677, USA.
Fazila
F
Zulfiqar
National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University MS 38677, USA; Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University MS 38677, USA.
Samir A
SA
Ross
National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University MS 38677, USA.
Desmond
D
Slade
National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University MS 38677, USA.
Safwat A
SA
Ahmed
National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University MS 38677, USA.
Mohamed M
MM
Radwan
National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University MS 38677, USA.
Zulfiqar
Z
Ali
National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University MS 38677, USA; Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University MS 38677, USA.
Ikhlas A
IA
Khan
National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University MS 38677, USA; Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University MS 38677, USA.
Mahmoud A
MA
ElSohly
C-bridged dimer; Cannabis sativa; Cannabisol
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