Emerging microfluidic devices for cancer cells/biomarkers manipulation and detection.
Circulating tumour cells (CTCs) are active participants in the metastasis process and account for ∼90% of all cancer deaths. As CTCs are admixed with a very large amount of erythrocytes, leukocytes, and platelets in blood, CTCs are very rare, making their isolation, capture, and detection a major technological challenge. Microfluidic technologies have opened-up new opportunities for the screening of blood samples and the detection of CTCs or other important cancer biomarker-proteins. In this study, the authors have reviewed the most recent developments in microfluidic devices for cells/biomarkers manipulation and detection, focusing their attention on immunomagnetic-affinity-based devices, dielectrophoresis-based devices, surface-plasmon-resonance microfluidic sensors, and quantum-dots-based sensors.
School of Engineering and Sciences, Tecnologico de Monterrey, Avenue Eugenio Garza Sada 2501 Sur, Monterrey, Mexico.
Victor Hugo
VH
Perez-Gonzalez
School of Engineering and Sciences, Tecnologico de Monterrey, Avenue Eugenio Garza Sada 2501 Sur, Monterrey, Mexico.
Roberto Carlos
RC
Gallo-Villanueva
School of Engineering and Sciences, Tecnologico de Monterrey, Avenue Eugenio Garza Sada 2501 Sur, Monterrey, Mexico.
Sergio
S
Camacho-Leon
School of Biotechnology and Health Sciences, Tecnologico de Monterrey, Avenue Eugenio Garza Sada 2501 Sur, Monterrey, Mexico.
Jose Isabel
JI
Gomez-Quiñones
School of Engineering and Sciences, Tecnologico de Monterrey, Avenue Eugenio Garza Sada 2501 Sur, Monterrey, Mexico.
Jose Manuel
JM
Rodriguez-Delgado
School of Engineering and Sciences, Tecnologico de Monterrey, Avenue Eugenio Garza Sada 2501 Sur, Monterrey, Mexico. smart@itesm.mx.
Sergio Omar
SO
Martinez-Chapa
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