Bactericidal, quorum quenching and anti-biofilm nanofactories: a new niche for nanotechnologists.
Despite several conventional potent antibacterial therapies, bacterial infections pose a significant threat to human health because they are emerging as the leading cause of death worldwide. Due to the development of antibiotic resistance in bacteria, there is a pressing demand to discover novel approaches for developing more effective therapies to treat multidrug-resistant bacterial strains and biofilm-associated infections. Therefore, attention has been especially devoted to a new and emerging branch of science "nanotechnology" to design non-conventional antimicrobial chemotherapies. A range of nanomaterials and nano-sized carriers for conventional antimicrobial agents have fully justified their potential to combat bacterial diseases by reducing cell viability, by attenuating quorum sensing, and by inhibiting/or eradicating biofilms. This communication summarizes emerging nano-antimicrobial therapies in treating bacterial infections, particularly using antibacterial, quorum quenching, and anti-biofilm nanomaterials as new approaches to tackle the current challenges in combating infectious diseases.
a Pharmacognosy & Ethnopharmacology Division , CSIR-National Botanical Research Institute , Lucknow , India.
Brahma N
BN
Singh
a Pharmacognosy & Ethnopharmacology Division , CSIR-National Botanical Research Institute , Lucknow , India.
Prateeksha
b Lichenology laboratory , Plant Biodiversity and Conservation Biology Division, CSIR-National Botanical Research Institute , Lucknow , Uttar Pradesh , India.
Dalip K
DK
Upreti
c TERI-Deakin Nanobiotechnology Centre, TERI Gram, The Energy and Resources Institute, Gurgaon , Haryana , India.|d Centre of Excellence in Materials Science (Nanomaterials), Z. H. College of Engineering and Technology , Aligarh Muslim University, Aligarh , Uttar Pradesh , India.
Braj Raj
BR
Singh
d Centre of Excellence in Materials Science (Nanomaterials), Z. H. College of Engineering and Technology , Aligarh Muslim University, Aligarh , Uttar Pradesh , India.|e Laboratory of Aquaculture & Artemia Reference Center , Ghent University , Gent , Belgium.
Tom
T
Defoirdt
f Molecular Glyco-biotechnology Group, Discipline of Biochemistry , School of Natural Sciences, National University of Ireland Galway , Galway , Ireland.
Vijai K
VK
Gupta
g Laboratório de Bioquímica, Instituto Butantan , São Paulo , SP , Brazil.
Ana Olivia
AO
De Souza
h Mycology & Plant Pathology, Institute of Agricultural Sciences, Banaras Hindu University , Varanasi , Uttar Pardesh , India.
Harikesh Bahadur
HB
Singh
i Mountain Research Centre (CIMO), ESA, Polytechnic Institute of Bragança , Campus de Santa Apolónia , Bragança , Portugal.
João C M
JC
Barreira
i Mountain Research Centre (CIMO), ESA, Polytechnic Institute of Bragança , Campus de Santa Apolónia , Bragança , Portugal.
Isabel C F R
IC
Ferreira
j Biologisch-Pharmazeutische Fakultät , Institut für Allgemeine Botanik und Pflanzenphysiologie, Friedrich-Schiller Universität Jena , Jena , Germany.
Khabat
K
Vahabi
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects* / Q000472:pathogenicity; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D018441:Biofilms / Q000187:drug effects / Q000254:growth & development; D006801:Humans; D036103:Nanotechnology / Q000379:methods* / Q000639:trends; D053038:Quorum Sensing / Q000187:drug effects*
D000900:Anti-Bacterial Agents
Antibacterial; anti-biofilm; nanomaterials; nanotoxicology; quorum quenching