Behavioral phenotype in a child with Prader-Willi syndrome and comorbid 47, XYY.
We report a 12-year-old male with Prader-Willi syndrome (PWS) and 47, XYY syndrome. Genetic work up revealed 47, XYY karyotype. PWS diagnosis was made by polymerase chain reaction methylation and maternal uniparental disomy (mUPD) was determined to be the etiology. Review of distinct behavioral features, possible interplay between the two syndromes and considerations for diagnoses are presented. To our knowledge, this is the first report of behavioral features in PWS with comorbid 47, XYY.
Autism and Obsessive Compulsive Spectrum Program, Department of Psychiatry, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.
Pooja
P
Palkar
Autism and Obsessive Compulsive Spectrum Program, Department of Psychiatry, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.
Anahid
A
Kabasakalian
Autism and Obsessive Compulsive Spectrum Program, Department of Psychiatry, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.
Bonnie
B
Taylor
Autism and Obsessive Compulsive Spectrum Program, Department of Psychiatry, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.
Ellen
E
Doernberg
Autism and Obsessive Compulsive Spectrum Program, Department of Psychiatry, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.
Casara Jean
CJ
Ferretti
Autism and Obsessive Compulsive Spectrum Program, Department of Psychiatry, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.
Genoveva
G
Uzunova
Autism and Obsessive Compulsive Spectrum Program, Department of Psychiatry, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.
Eric
E
Hollander
47; Prader-Willi syndrome; XYY; attention deficit hyperactivity disorder; autism spectrum disorder
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