A saltationist theory of cancer evolution.
A new study based on single-nucleus sequencing reports that triple-negative breast cancers acquire copy number aberrations in short punctuated bursts in the earliest stages of tumor evolution, rather than continuously and gradually, challenging prevailing models of tumor evolution.
University of Cambridge, Cancer Research UK Cambridge Institute, Cambridge, UK.
Florian
0000-0002-2784-5308
F
Markowetz
D056915:DNA Copy Number Variations / Q000235:genetics*; D005260:Female; D018740:Genetic Heterogeneity; D006801:Humans; D012641:Selection, Genetic / Q000235:genetics*; D064726:Triple Negative Breast Neoplasms / Q000235:genetics* / Q000473:pathology
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