Size effect of Au/PAMAM contrast agent on CT imaging of reticuloendothelial system and tumor tissue.
Polyamidoamine (PAMAM)-entrapped Au nanoparticles were synthesized with distinct sizes to figure out the size effect of Au-based contrast agent on CT imaging of passively targeted tissues. Au/PAMAM nanoparticles were first synthesized with narrow distribution of particles size of 22.2 ± 3.1, 54.2 ± 3.7, and 104.9 ± 4.7 nm in diameters. Size effect leads no significant difference on X-ray attenuation when Au/PAMAM was ≤0.05 mol/L. For CT imaging of a tumor model, small Au/PAMAM were more easily internalized via endocytosis in the liver, leading to more obviously enhanced contrast. Similarly, contrast agents with small sizes were more effective in tumor imaging because of the enhanced permeability and retention effect. Overall, the particle size of Au/PAMAM heavily affected the efficiency of CT enhancement in imaging RES and tumors.
Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center of Cancer, Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, Huan-Hu-Xi Road, He Xi District, Tianjin, 300060, China. docwangwei@126.com.
Wei
W
Wang
Department of Radiology, Tianjin Hospital, Tianjin, 300060, China.
Jian
J
Li
Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center of Cancer, Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, Huan-Hu-Xi Road, He Xi District, Tianjin, 300060, China.
Ransheng
R
Liu
Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center of Cancer, Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, Huan-Hu-Xi Road, He Xi District, Tianjin, 300060, China.
Aixu
A
Zhang
Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center of Cancer, Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, Huan-Hu-Xi Road, He Xi District, Tianjin, 300060, China.
Zhiyong
Z
Yuan
Au nanoparticles; Computed tomography; Passive targeting; Reticuloendothelial system; Size effect; Tumor tissue
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