Intakes of Folate and Vitamin B12 and Biomarkers of Status in the Very Old: The Newcastle 85+ Study.
Very old adults are at increased risk of folate and vitamin B12 deficiencies due to reduced food intake and gastrointestinal absorption. The main aim was to determine the association between folate and vitamin B12 intake from total diets and food groups, and status. Folate or vitamin B12 intakes (2 × 24 h multiple pass recalls) and red blood cell (RBC) folate or plasma vitamin B12 (chemiluminescence immunoassays) concentrations were available at baseline for 731 participants aged 85 from the Newcastle 85+ Study (North-East England). Generalized additive and binary logistic models estimated the associations between folate and vitamin B12 intakes from total diets and food groups, and RBC folate and plasma B12. Folate intake from total diets and cereal and cereal products was strongly associated with RBC folate (p< 0.001). Total vitamin B12 intake was weakly associated with plasma vitamin B12 (p= 0.054) but those with higher intakes from total diets or meat and meat products were less likely to have deficient status. Women homozygous for theFUT2G allele had higher concentrations of plasma vitamin B12. Cereals and cereal products are a very important source of folate in the very old. Higher intakes of folate and vitamin B12 lower the risk of "inadequate" status.
School of Agriculture Food and Rural Development, Newcastle University, Newcastle upon Tyne NE1 7RU, UK. n.m.p.mendonca@newcastle.ac.uk.|Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne NE2 4AX, UK. n.m.p.mendonca@newcastle.ac.uk.|Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. n.m.p.mendonca@newcastle.ac.uk.
Nuno
N
Mendonça
Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne NE2 4AX, UK. john.mathers@newcastle.ac.uk.|Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. john.mathers@newcastle.ac.uk.|Institute of Cellular Medicine, Newcastle upon Tyne NE2 4HH, UK. john.mathers@newcastle.ac.uk.
John C
JC
Mathers
Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne NE2 4AX, UK. Ashley.Adamson@newcastle.ac.uk.|Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. Ashley.Adamson@newcastle.ac.uk.|Institute of Health and Society, Newcastle University, Newcastle upon Tyne NE2 5PL, UK. Ashley.Adamson@newcastle.ac.uk.
Ashley J
AJ
Adamson
Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne NE2 4AX, UK. Carmen.martin-ruiz@newcastle.ac.uk.
Carmen
C
Martin-Ruiz
School of Agriculture Food and Rural Development, Newcastle University, Newcastle upon Tyne NE1 7RU, UK. Chris.seal@newcastle.ac.uk.|Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. Chris.seal@newcastle.ac.uk.
Chris J
CJ
Seal
Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne NE2 4AX, UK. carol.jagger@newcastle.ac.uk.|Institute of Health and Society, Newcastle University, Newcastle upon Tyne NE2 5PL, UK. carol.jagger@newcastle.ac.uk.
Carol
C
Jagger
School of Agriculture Food and Rural Development, Newcastle University, Newcastle upon Tyne NE1 7RU, UK. Tom.hill@newcastle.ac.uk.|Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne NE2 4AX, UK. Tom.hill@newcastle.ac.uk.|Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. Tom.hill@newcastle.ac.uk.
Tom R
TR
Hill
FUT2; MTHFR; Newcastle 85+ Study; food groups; red blood cell folate; vitamin B12; ‘aged 80 and over’
J Nutr. 2012 May;142(5):886-93
22437563
BMJ. 2009 Dec 22;339:b4904
20028777
Nutr Res. 2016 Feb;36(2):109-16
26597770
Am J Clin Nutr. 2007 Aug;86(2):434-43
17684216
Am J Clin Nutr. 2015 Jun;101(6):1295-304
25948668
J Nutr. 2002 Jul;132(7):2059-64
12097693
Lancet. 2007 Jan 20;369(9557):208-16
17240287
Clin Biochem. 2010 May;43(7-8):645-9
20144600
Eur J Clin Nutr. 1998 Dec;52(12):917-23
9881887
Rep Health Soc Subj (Lond). 1991;41:1-210
1961974
Nutr Rev. 2007 Oct;65(10):451-8
17972439
Am J Clin Nutr. 2006 Jan;83(1):52-8
16400049
Hum Mol Genet. 2014 Aug 15;23(16):4420-32
24688116
Br J Nutr. 2016 Aug;116(4):751-61
27363567
Am J Hum Genet. 2009 Apr;84(4):477-82
19303062
Am J Clin Nutr. 1966 Mar;18(3):176-84
5948742
Nutr Res Rev. 2001 Dec;14(2):267-94
19087427
Am J Clin Nutr. 2010 Jan;91(1):64-72
19828716
Clin Chem. 2009 Dec;55(12):2198-206
19833840
Nutrients. 2015 Sep 14;7(9):7781-97
26389945
Stroke. 2009 Apr;40(4):1365-72
19228852
J Nutr. 2001 Feb;131(2):291-3
11160548
Nephrol Dial Transplant. 2004 Jun;19(6):1474-9
14993514
Ann Clin Biochem. 2013 Jul;50(Pt 4):315-29
23592803
Nat Genet. 2008 Oct;40(10):1160-2
18776911
Mech Ageing Dev. 2011 Oct;132(10):496-502
21864562
Ann Neurol. 2005 Dec;58(6):847-57
16254972
PLoS One. 2014 Oct 10;9(10):e108370
25302500
Am J Clin Nutr. 1978 May;31(5):825-30
645629
Am J Clin Nutr. 2010 May;91(5):1455S-1460S
20219964
Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):2128-35
17932361
Nat Rev Cancer. 2013 Aug;13(8):572-83
23822983
Am J Med. 2005 Feb;118(2):161-7
15694902
J Am Coll Nutr. 2007 Jun;26(3):272-8
17634173
Stroke. 2005 Jul;36(7):1426-31
15933256
Neuroepidemiology. 2006;27(4):188-200
17035715
Am J Clin Nutr. 2009 Apr;89(4):1078-87
19190073
Gastroenterology. 1991 Oct;101(4):1039-45
1889697
J Acad Nutr Diet. 2012 May;112(5):657-663.e4
22709770
Bone. 2012 Sep;51(3):376-82
22749888
Am J Clin Nutr. 2007 Nov;86(5):1405-13
17991653
Br J Nutr. 2016 Jun;115(12):2170-80
27087119
Br J Nutr. 2015 Apr 28;113(8):1195-206
25822905
Proc Nutr Soc. 2016 Aug;75(3):420-30
27165559
Eur J Clin Nutr. 2003 Feb;57(2):349-57
12571671
Eur J Clin Nutr. 1998 Aug;52(8):582-7
9725659
Nutrients. 2015 Mar 30;7(4):2176-92
25830943