Miniaturization for Point-of-Care Analysis: Platform Technology for Almost Every Biomedical Assay.
Platform technologies for the changing need of diagnostics are one of the main challenges in medical device technology. From one point-of-view the demand for new and more versatile diagnostic is increasing due to a deeper knowledge of biomarkers and their combination with diseases. From another point-of-view a decentralization of diagnostics will occur since decisions can be made faster resulting in higher success of therapy. Hence, new types of technologies have to be established which enables a multiparameter analysis at the point-of-care. Within this review-like article a system called Fraunhofer ivD-platform is introduced. It consists of a credit-card sized cartridge with integrated reagents, sensors and pumps and a read-out/processing unit. Within the cartridge the assay runs fully automated within 15-20 minutes. Due to the open design of the platform different analyses such as antibody, serological or DNA-assays can be performed. Specific examples of these three different assay types are given to show the broad applicability of the system.
Soeren
S
Schumacher
Dorian
D
Sartorius
Eva
E
Ehrentreich-Förster
Frank F
FF
Bier
DNA; Lab-on-a-Chip; Miniaturization; antibody; antigen
Proteomics. 2006 Mar;6(5):1376-84
16456884
Lab Chip. 2012 Feb 7;12(3):464-73
22038328
Nat Rev Microbiol. 2010 Dec;8(12 Suppl):S2-6
21548182
Proc Natl Acad Sci U S A. 1993 May 15;90(10):4338-44
8506271
Sens Actuators B Chem. 2006 Feb 27;113(2):655-663
32288236
Biosens Bioelectron. 2011 Jan 15;26(5):1895-901
20400289
Clin Chim Acta. 2009 May;403(1-2):244-8
19302991
Med Sci Monit. 2004 May;10(5):RA111-23
15114285