Clinical experience with the use of anti-CdtB and anti-vinculin antibodies in patients with diarrhea in Mexico.
BACKGROUND
Circulating anti-CdtB/anti-vinculin antibodies have been validated as biomarkers to distinguish IBS-D from IBD, but there is no experience with them in Latin America.


METHODS
The analysis was carried out on patients seen at a FGIDs/motility clinic over the last 7 months for diarrhea with abdominal pain and/or bloating who were tested for these antibodies. The patients were diagnosed according to the Rome III criteria or with organic disorders, and those presenting with IBS were further classified as post-infectious (PI) or non-PI-IBS.


RESULTS
Thirty patients were studied. Positive biomarkers were found in IBS-D and IBS-D Overlap (58.8%) and IBS-M (33.3%), with no differences between PI-IBS (71.4%) vs. non-PI-IBS (41.7%) subjects (P=.21). There was no positivity in patients with other FGIDs or organic diarrhea, except for one with small intestinal bacterial overgrowth (SIBO).


CONCLUSIONS
Our findings support the use of this test as a first-line diagnostic tool to confirm the presence of IBS-D/IBS-M according to the Rome III criteria.
Laboratorio de Hígado, Páncreas y Motilidad (HIPAM), Unidad de Investigación en Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad de México, México; Clínica Lomas Altas, SC, Ciudad de México, México. Electronic address: maxjulio@prodigy.net.mx.
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M
Schmulson
Laboratorio Biomédica de Referencia, Ciudad de México, México.
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R
Balbuena
Laboratorio Biomédica de Referencia, Ciudad de México, México.
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C
Corona de Law
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019138:Antibodies, Blocking / Q000627:therapeutic use*; D001427:Bacterial Toxins / Q000037:antagonists & inhibitors / Q000276:immunology*; D003967:Diarrhea / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000150:complications / Q000188:drug therapy; D008297:Male; D008800:Mexico; D008875:Middle Aged; D012189:Retrospective Studies; D016596:Vinculin / Q000037:antagonists & inhibitors*; D055815:Young Adult
D019138:Antibodies, Blocking; D001427:Bacterial Toxins; C067044:cytolethal distending toxin; D016596:Vinculin
Anti-CdtB/anti-vinculin; Anti-CdtB/anti-vinculina; Biomarcadores; Biomarkers; Chronic diarrhea; Diagnosis; Diagnóstico; Diarrea crónica; Irritable bowel syndrome with diarrhea; Síndrome de intestino irritable con diarrea