The genetic basis of pigmentation in alopecia areata.
Alopecia areata (AA) is a common hair loss disorder characterized by discrete, well demarcated areas of non-scarring terminal hair alopecia, with the calculated lifetime risk of ~2%. In past decades, linkage and GWA studies have implicated dozens of susceptibility genes/loci that are linked to the development of AA. Fischer et al performed a genome-wide CNV analysis of 585 AA patients and 1,340 controls in a European population. This is the first genome-wide study of CNV to be performed in AA samples, and the association finding in the MCHR2 gene region further underscores the potential role of pigmentation in AA development.
Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Min
M
Zheng
Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Yunqing
Y
Ren
D000506:Alopecia Areata; D015331:Cohort Studies; D056915:DNA Copy Number Variations; D055106:Genome-Wide Association Study; D006801:Humans; D010858:Pigmentation; D043562:Receptors, G-Protein-Coupled; D011979:Receptors, Pituitary Hormone
C431280:MCHR2 protein, human; D043562:Receptors, G-Protein-Coupled; D011979:Receptors, Pituitary Hormone
MCHR2; alopecia areata; copy number variation; genetic