Polymeric nanocapsules as a technological alternative to reduce the toxicity caused by meloxicam in mice.
This study determined whether meloxicam in nanocapsules modifies stomach and liver damage caused by free meloxicam in mice. Male Swiss mice were treated with blank nanocapsules or meloxicam in nanocapsules or free meloxicam (10 mg/kg, intragastrically, daily for five days). On the seventh day, blood was collected to determine biochemical markers (glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, total bilirubin, unconjugated bilirubin, albumin and alkaline phosphatase). Stomachs and livers were removed for histological analysis. There was no significant difference in the biochemical markers in the plasma of mice. Meloxicam in nanocapsules did not have an ulcerogenic potential in the stomach or cause lipid peroxidation in the stomach and liver. Free meloxicam increased the ulcerogenic potential in the stomach and lipid peroxidation in the stomach and liver. Meloxicam in nanocapsules caused less histological changes than free meloxicam. In conclusion, polymeric nanocapsules can represent a technological alternative to reduce the toxicity caused by meloxicam.
Programa de Pós-graduação em Nanociências, Centro de Ciências Tecnológicas, Centro Universitário Franciscano, Santa Maria, CEP 97010-032, RS, Brazil.
Benonio T
BT
Villalba
Programa de Pós-graduação em Nanociências, Centro de Ciências Tecnológicas, Centro Universitário Franciscano, Santa Maria, CEP 97010-032, RS, Brazil.
Francine R
FR
Ianiski
Grupo de Pesquisa em Neurobiotecnologia, Universidade Federal de Pelotas, Capão do Leão, CEP: 96010-900, RS, Brazil.
Ane G
AG
Vogt
Grupo de Pesquisa em Neurobiotecnologia, Universidade Federal de Pelotas, Capão do Leão, CEP: 96010-900, RS, Brazil.
Mikaela P
MP
Pinz
Grupo de Pesquisa em Neurobiotecnologia, Universidade Federal de Pelotas, Capão do Leão, CEP: 96010-900, RS, Brazil.
Angélica S
AS
Reis
Programa de Pós-graduação em Nanociências, Centro de Ciências Tecnológicas, Centro Universitário Franciscano, Santa Maria, CEP 97010-032, RS, Brazil.
Rodrigo A
RA
Vaucher
Laboratório Regional de Diagnóstico Faculdade de Veterinária, Universidade Federal de Pelotas, Capão do Leão, CEP: 96010-900, RS, Brazil.
Mauro P
MP
Soares
Grupo de Pesquisa em Neurobiotecnologia, Universidade Federal de Pelotas, Capão do Leão, CEP: 96010-900, RS, Brazil. Electronic address: ethelwilhelm@yahoo.com.br.
Ethel A
EA
Wilhelm
Grupo de Pesquisa em Neurobiotecnologia, Universidade Federal de Pelotas, Capão do Leão, CEP: 96010-900, RS, Brazil. Electronic address: cristiane_luchese@yahoo.com.br.
Cristiane
C
Luchese
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002208:Caproates / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005753:Gastric Mucosa / Q000378:metabolism; D007783:Lactones / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D000077239:Meloxicam; D051379:Mice; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry*; D009929:Organ Size / Q000187:drug effects; D011136:Polysorbates / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D013270:Stomach / Q000187:drug effects* / Q000473:pathology; D013329:Structure-Activity Relationship; D013843:Thiazines / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000633:toxicity; D013844:Thiazoles / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000633:toxicity
D002208:Caproates; D007783:Lactones; D053769:Nanocapsules; D011136:Polysorbates; D013843:Thiazines; D013844:Thiazoles; C121056:caprolactone; D000077239:Meloxicam
Lipid peroxidation; Meloxicam; Nanoparticles; Nanotoxicology; Ulcerogenic potential