Use of Fungal Diagnostics and Therapy in Pediatric Cancer Patients in Resource-Limited Settings.
Fungal diseases are an important cause of mortality in immunocompromised hosts, and their incidence in pediatric cancer patients in low- to middle-income countries is underestimated. In this review, we present relevant, up-to-date information about the most common opportunistic and endemic fungal diseases among children with cancer, their geographic distribution, and recommended diagnostics and treatment. Efforts to improve the care of children with cancer and fungal disease must address the urgent need for sustainable and cost-effective solutions that improve training, fungal disease testing capability, and the use of available resources. We hope that the collective information presented here will be used to advise healthcare providers, regional and country health leaders, and policymakers of the current challenges in diagnosing and treating fungal infections in children with cancer in low- to middle-income countries.
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA; Division of Infectious Diseases, Department of Pediatrics, University of Tennessee Health Sciences Center, Memphis, TN, USA.
Sheena
S
Mukkada
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
Jeannette
J
Kirby
Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Nopporn
N
Apiwattanakul
Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Randall T
RT
Hayden
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA; Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN, USA; International Outreach Program, St. Jude Children's Research Hospital, Memphis, TN, USA.
Miguela A
MA
Caniza
antifungals; fungal biomarkers; fungus; low- to middle-income countries; pediatric; resource-limited settings.
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