Circadian regulation of auditory function.
The circadian system integrates environmental cues to regulate physiological functions in a temporal fashion. The suprachiasmatic nucleus, located in the hypothalamus, is the master clock that synchronizes central and peripheral organ clocks to orchestrate physiological functions. Recently, molecular clock machinery has been identified in the cochlea unravelling the potential involvement in the circadian regulation of auditory functions. Here, we present background information on the circadian system and review the recent findings that introduce circadian rhythms to the auditory field. Understanding the mechanisms by which circadian rhythms regulate auditory function will provide fundamental knowledge on the signalling networks that control vulnerability and resilience to auditory insults.
Department of Physiology and Pharmacology, Laboratory of Experimental Audiology, Karolinska Institutet, 171 77 Stockholm, Sweden.
Vasiliki
V
Basinou
Department of Physiology and Pharmacology, Laboratory of Experimental Audiology, Karolinska Institutet, 171 77 Stockholm, Sweden; Department of Otolaryngology, Ajou University School of Medicine, 164, Worldcup-ro, Yeongtong-gu, Suwon, 16499, South Korea.
Jung-Sub
JS
Park
Department of Physiology and Pharmacology, Laboratory of Experimental Audiology, Karolinska Institutet, 171 77 Stockholm, Sweden.
Christopher R
CR
Cederroth
Department of Physiology and Pharmacology, Laboratory of Experimental Audiology, Karolinska Institutet, 171 77 Stockholm, Sweden. Electronic address: Barbara.Canlon@ki.se.
Barbara
B
Canlon
D000161:Acoustic Stimulation; D000818:Animals; D001306:Auditory Pathways / Q000378:metabolism / Q000502:physiology*; D001307:Auditory Perception; D057906:Circadian Clocks; D002940:Circadian Rhythm; D056925:Circadian Rhythm Signaling Peptides and Proteins / Q000378:metabolism; D003051:Cochlea / Q000378:metabolism / Q000502:physiology*; D003463:Cues; D006309:Hearing; D006801:Humans; D015398:Signal Transduction
D056925:Circadian Rhythm Signaling Peptides and Proteins
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