Association between genetic polymorphisms of interleukins and cerebral infarction risk: a meta-analysis.
Interleukins (ILs) are the most typical inflammatory and immunoregulatory cytokines. Evidences have shown that polymorphisms in ILs are associated with cerebral infarction risk. However, the results remain inconclusive. The present study was to evaluate the role of ILs polymorphisms in cerebral infarction susceptibility. Relevant case-control studies published between January 2000 and December 2015 were searched and retrieved from the electronic databases of Web of Science, PubMed, Embase and the Chinese Biomedical Database. The odds ratio (OR) with its 95% confidence interval (CI) were employed to calculate the strength of association. A total of 55 articles including 12619 cerebral infarction patients and 14436 controls were screened out. Four ILs (IL-1, IL-6, IL-10 and IL-18) contained nine single nucleotide polymorphisms (SNPs; IL-1α -899C/T, IL-1β -511C/T and IL-1β +3953C/T; IL-6 -174G/C and -572C/G; IL-10 -819C/T and -1082A/G; IL-18 -607C/A and -137G/C). Our result showed that IL-1α -899C/T and IL-18 -607C/A (under all the genetic models), and IL-6 -572C/G (under the allelic model, heterogeneity model and dominant model) were associated with increased the risk of cerebral infarction (P<0.05). Subgroup analysis by ethnicity showed that IL-6 -174G/C polymorphism (under all the five models) and IL-10 -1082A/G polymorphism (under the allelic model and heterologous model) were significantly associated with increased the cerebral infarction risk in Asians. Other genetic polymorphisms were not related with cerebral infarction susceptibility under any genetic models. In conclusion, IL-1α -899C/T, IL-6 -572C/G and IL-18 -607C/A might be risk factors for cerebral infarction development. Further studies with well-designed and large sample size are still required.
Department of Laboratory Medicine, Huaihe Hospital of Henan University, Kaifeng 475000, Henan, China.
Jiantao
J
Wang
Department of Laboratory Medicine, Huaihe Hospital of Henan University, Kaifeng 475000, Henan, China.
Niannian
N
Fan
Department of Cardiology, Third Affiliated Hospital of Third Military Medical University, Chongqing 400042, China.
Yili
Y
Deng
Department of Neurology, Third Affiliated Hospital of Third Military Medical University, Chongqing 400042, China.
Jie
J
Zhu
Department of Neurology, Third Affiliated Hospital of Third Military Medical University, Chongqing 400042, China.
Jing
J
Mei
Chongqing Medical University, Chongqing 400016, China.
Yao
Y
Chen
Department of Neurology, Third Affiliated Hospital of Third Military Medical University, Chongqing 400042, China hengyy8@yeah.net.
Heng
H
Yang
cerebral infarction; interleukin; meta-analysis; polymorphism; risk
Clin Chem Lab Med. 2006;44(8):918-23
16879054
Eur J Neurol. 2005 Dec;12(12):989-93
16324093
Arterioscler Thromb Vasc Biol. 2005 Jan;25(1):222-7
15539626
Int J Clin Exp Pathol. 2015 Oct 01;8(10):13489-94
26722562
Funct Neurol. 2012 Jan-Mar;27(1):35-40
22687165
Vitam Horm. 2006;74:207-28
17027516
J Basic Clin Physiol Pharmacol. 2014 May 1;25(2):131-7
24515999
Biomed Res Int. 2013;2013:961039
24063019
Atherosclerosis. 2008 Nov;201(1):124-9
18336824
Arterioscler Thromb Vasc Biol. 2006 Aug;26(8):1920-5
16741147
J Cardiovasc Transl Res. 2013 Oct;6(5):834-51
24006091
Mol Neurobiol. 2016 May;53(4):2698-704
26253723
Theor Biol Forum. 2014;107(1-2):13-45
25936211
Cell Metab. 2013 Nov 5;18(5):614-6
24206661
Clin Exp Med. 2016 May;16(2):203-11
25847570
Atherosclerosis. 2012 Aug;223(2):473-7
22766330
Cerebrovasc Dis. 2003;15(4):276-81
12686792
Pak J Med Sci. 2015 Jan-Feb;31(1):198-202
25878643
Genet Mol Res. 2013 Jul 15;12(3):2423-31
23766027
Gene. 2015 Apr 15;560(2):200-4
25659766
Immunology. 2012 Feb;135(2):112-24
22044352
J Neuroinflammation. 2012 Jul 06;9:162
22769019
Cytokine. 2010 Dec;52(3):221-4
21030268
Pharmacol Ther. 2014 Feb;141(2):125-39
24076269
Brain Res Bull. 2010 Jan 15;81(1):38-42
19786079
Gene. 2012 May 10;499(1):61-9
22417897
Brain Res Bull. 2008 Jan 31;75(1):158-65
18158110
Nihon Rinsho. 1993 Nov;51 Suppl:433-9
8283698
Int J Clin Exp Pathol. 2015 Oct 01;8(10):13500-4
26722564
Cell Mol Life Sci. 2005 Apr;62(7-8):824-33
15868407
Biochem Biophys Res Commun. 2010 Jan 1;391(1):481-5
19919828
Neurology. 2013 Jul 16;81(3):264-72
23858408
Nihon Rinsho. 2006 Nov;64(11):2039-44
17087294
Surg Neurol. 2006 Sep;66(3):232-45
16935624
Gene. 2014 Apr 15;539(2):258-62
24486505
Eur J Neurol. 2011 Apr;18(4):637-43
20880001
Stroke. 2000 Oct;31(10):2325-9
11022058
Exp Gerontol. 2013 Sep;48(9):960-5
23872300
Int J Clin Exp Med. 2015 Feb 15;8(2):1888-95
25932117
Stroke. 1981 Jul-Aug;12(4):474-7
7314170
Cell Biochem Biophys. 2015 Mar;71(2):637-47
25223242
PLoS One. 2014 Apr 14;9(4):e94631
24732312
Front Cell Neurosci. 2015 Feb 06;9:18
25705177
Cytokine. 2003 Jul;23(1-2):41-6
12901853
J Mol Neurosci. 2000 Jun;14(3):191-6
10984195
Ann Neurosci. 2015 Apr;22(2):61-9
26130909
Folia Neuropathol. 2012;50(2):147-51
22773460
Can J Cardiol. 2013 Jan;29(1):67-74
22999193
Neural Regen Res. 2015 Nov;10(11):1809-13
26807116
Stroke. 2004 Oct;35(10):2270-5
15308783
J Genet. 2011 Aug;90(2):361-4
21869490
Braz J Med Biol Res. 2013 Jun;46(6):502-6
23739747
J Clin Neurosci. 2014 Feb;21(2):298-300
24210798
Genet Mol Res. 2015 Oct 26;14(4):13076-83
26535620
Neurosci Lett. 2002 May 10;324(1):29-32
11983287
J Neurol Neurosurg Psychiatry. 2004 Jan;75(1):170-1
14707339
BMC Med Genet. 2013 Oct 09;14:109
24107076
Stroke. 2012 Sep;43(9):2278-82
22744645
Am J Psychiatry. 2000 May;157(5):683-94
10784457
Brain Res Bull. 2010 Apr 5;81(6):590-4
20097272
J Stroke Cerebrovasc Dis. 2013 Jul;22(5):683-9
22410655
Stroke. 2003 Apr;34(4):881-5
12637697
Ir J Med Sci. 2004 Oct-Dec;173(4):200-3
16323614
J Neurol Sci. 2001 Nov 15;192(1-2):41-7
11701151
Cytokine. 2012 Jun;58(3):398-405
22425140
Cerebrovasc Dis. 2005;19(2):91-5
15608432
J Inflamm Res. 2013 Aug 20;6:121-8
24062616
J Stroke Cerebrovasc Dis. 2016 Feb;25(2):461-8
26654671
Neurol Sci. 2003 Oct;24(3):117-24
14600822
Neurocrit Care. 2012 Jun;16(3):421-7
21989842
Mol Biol (Mosk). 2015 Mar-Apr;49(2):224-48
26065252
Cerebrovasc Dis. 2009;27(5):493-501
19342825
Ann Neurol. 2012 Mar;71(3):289-303
22451199
Acta Neurol Scand. 2014 Mar;129(3):173-7
23803011
Neurol India. 2006 Dec;54(4):366-9
17114844