Structural, antigenic and immunogenic features of respiratory syncytial virus glycoproteins relevant for vaccine development.
Extraordinary progress in the structure and immunobiology of the human respiratory syncytial virus glycoproteins has been accomplished during the last few years. Determination of the fusion (F) glycoprotein structure folded in either the prefusion or the postfusion conformation was an inspiring breakthrough not only to understand the structural changes associated with the membrane fusion process but additionally to appreciate the antigenic intricacies of the F protein. Furthermore, these developments have opened new avenues for structure-based designs of promising hRSV vaccine candidates. Finally, recent advances in our knowledge of the attachment (G) glycoprotein and its interaction with cell-surface receptors have revitalized interest in this molecule as a vaccine, as well as its role in hRSV immunobiology.
Unidad de Biología Viral, Centro Nacional de Microbiología and CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain. Electronic address: jmelero@isciii.es.
José A
JA
Melero
Unidad de Biología Viral, Centro Nacional de Microbiología and CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
Vicente
V
Mas
Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, United States. Electronic address: Jason.S.McLellan@Dartmouth.edu.
Jason S
JS
McLellan
D000956:Antigens, Viral / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D006023:Glycoproteins / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D011487:Protein Conformation; D022261:Respiratory Syncytial Virus Vaccines / Q000276:immunology*; D018113:Respiratory Syncytial Virus, Human / Q000737:chemistry / Q000276:immunology* / Q000502:physiology; D053586:Virus Internalization
D000956:Antigens, Viral; D006023:Glycoproteins; D022261:Respiratory Syncytial Virus Vaccines
RSV glycoproteins and vaccine development
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