Fifty years of brain imaging in neonatal encephalopathy following perinatal asphyxia.
In the past brain imaging of term infants with hypoxic-ischemic encephalopathy (HIE) was performed with cranial ultrasound (cUS) and computed tomography (CT). Both techniques have several disadvantages sensitivity and specificity is limited compared with magnetic resonance imaging (MRI) and CT makes use of radiation. At present MRI including diffusion weighted MRI during the first week of life, has become the method of choice for imaging infants with HIE. In addition to imaging, blood vessels and blood flow can be visualized using MR angiography, MR venography, and arterial spin labeling. Since the use of these techniques additional lesions in infants with HIE, such as arterial ischemic stroke, sinovenous thrombosis, and subdural hemorrhages can be diagnosed, and the incidence appears to be higher than shown previously. Phosphorus magnetic resonance spectroscopy (MRS) has led to the concept of secondary energy failure in infants with HIE, but has not been widely used. Proton MRS of the basal ganglia and thalamus is one of the best predictors of neurodevelopmental outcome. cUS should still be used for screening infants admitted to a NICU with neonatal encephalopathy. In the future magnetic resonance techniques will be increasingly used as early biomarkers of neurodevelopmental outcome in trials of neuroprotective strategies.
Department of Neonatology, and Brain Center Rudolf Magnus, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
Floris
F
Groenendaal
Department of Neonatology, and Brain Center Rudolf Magnus, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
Linda S
LS
de Vries
D001237:Asphyxia / Q000150:complications / Q000000981:diagnostic imaging*; D001238:Asphyxia Neonatorum / Q000150:complications / Q000000981:diagnostic imaging*; D001921:Brain / Q000473:pathology; D003952:Diagnostic Imaging / Q000266:history*; D038524:Diffusion Magnetic Resonance Imaging; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D049268:Positron-Emission Tomography; D013113:Spin Labels; D013696:Temperature; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
D013113:Spin Labels
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