Clinical manifestation of late onset Pompe disease patients in Hong Kong.
Late onset Pompe disease is a rare inherited metabolic disease with diverse clinical manifestation. However, there is a lack of local data in Hong Kong. We aimed at performing an in-depth review of natural history of all patients in Hong Kong. Eleven patients were diagnosed to have the disease in Hong Kong from 2000 to 2013. All case records were reviewed and face-to-face interviews were conducted to complete a questionnaire regarding the clinical manifestation and diagnosis of the disease. The estimated birth incidence was 1/300,000. The age of diagnosis ranged from 9 to 44 years; all patients were ethnic Chinese. The median ages of first symptoms and first medical attention were 20.5(6-44) and 29(9-44) years respectively. The most common initial complaint was decreased exercise tolerance. Two patients' first complaint was difficulty with getting up from lying position and failure to perform sit up. The mean time from first medical attention to diagnosis was 1.3 years but one patient was diagnosed 8 years later. Half of the patients sought medical attention due to progressive shortness of breath and all of them developed type 2 respiratory failure requiring ventilator support during the first admission. Two patients became chair-bound and seven patients required assisted ventilation. Late onset Pompe disease tends to have an earlier and more aggressive clinical presentation in Chinese and lower birth incidence was found in Hong Kong.
Department of Medicine & Geriatrics, Princess Margaret Hospital, Hong Kong. Electronic address: cyp285@gmail.com.
Yim Pui
YP
Chu
Department of Medicine & Geriatrics, Princess Margaret Hospital, Hong Kong.
Bun
B
Sheng
Department of Medicine & Geriatrics, Princess Margaret Hospital, Hong Kong.
Kwok Kwong
KK
Lau
Department of Medicine & Geriatrics, Queen Elizabeth Hospital, Hong Kong.
Hiu Fai
HF
Chan
Department of Medicine & Geriatrics, United Christian Hospital, Hong Kong.
Grace Yee Wai
GY
Kam
Department of Pathology, Princess Margaret Hospital, Hong Kong.
Hencher Han Chih
HH
Lee
Department of Pathology, Princess Margaret Hospital, Hong Kong.
Chloe Miu
CM
Mak
D000293:Adolescent; D000328:Adult; D044466:Asian People; D002648:Child; D005260:Female; D056726:Genetic Association Studies; D006009:Glycogen Storage Disease Type II / Q000453:epidemiology* / Q000235:genetics / Q000503:physiopathology*; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D055815:Young Adult
Acid maltase deficiency; Chinese; Clinical manifestation; Glycogen storage disease type 2; Incidence; Late onset Pompe disease