DNA-Nanostructure-Gold-Nanorod Hybrids for Enhanced In Vivo Optoacoustic Imaging and Photothermal Therapy.
A functional cancer theranostic nanoplatform is developed, specifically tailored toward the optoacoustic modality by combining gold nanorods with DNA nanostructures (D-AuNR). DNA origami is used as an efficient delivery vehicle owing to its prominent tumor-targeting property. The D-AuNR hybrids display an enhanced tumor diagnostic sensitivity by improved optoacoustic imaging and excellent photothermal therapeutic properties in vivo.
The Key Laboratory of Molecular Imaging, Chinese Academy of Sciences, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
Yang
Y
Du
CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China.|CAS Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
Qiao
Q
Jiang
Institute for Biological and Medical Imaging (IBMI), Helmholtz Zentrum München and Technische Universität München, 85764, Neuherberg, Germany.
Nicolas
N
Beziere
CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China.
Linlin
L
Song
The Key Laboratory of Molecular Imaging, Chinese Academy of Sciences, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
Qian
Q
Zhang
The Key Laboratory of Molecular Imaging, Chinese Academy of Sciences, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
Dong
D
Peng
The Key Laboratory of Molecular Imaging, Chinese Academy of Sciences, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
Chongwei
C
Chi
The Key Laboratory of Molecular Imaging, Chinese Academy of Sciences, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
Xin
X
Yang
CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China.
Hongbo
H
Guo
Institute for Biological and Medical Imaging (IBMI), Helmholtz Zentrum München and Technische Universität München, 85764, Neuherberg, Germany.
Gaël
G
Diot
Institute for Biological and Medical Imaging (IBMI), Helmholtz Zentrum München and Technische Universität München, 85764, Neuherberg, Germany.
Vasilis
V
Ntziachristos
CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China.
Baoquan
B
Ding
The Key Laboratory of Molecular Imaging, Chinese Academy of Sciences, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
Jie
J
Tian
DNA origami; cancer; gold nanorods; optoacoustic imaging; photoacoustic imaging; photothermal therapy