Palladium-Catalyzed Allylation/Benzylation of H-Phosphinate Esters with Alcohols.
The Pd-catalyzed direct alkylation ofH-phosphinic acids and hypophosphorous acid with allylic/benzylic alcohols has been described previously. Here, the extension of this methodology toH-phosphinate esters is presented. The new reaction appears general, although its scope is narrower than with the acids, and its mechanism is likely different. Various alcohols are examined in their reaction with phosphinylidene compounds R¹R²P(O)H.
Department of Chemistry and Biochemistry, TCU Box 298860, Texas Christian University, Fort Worth, TX 76129, USA. a.fers-lidou@outlook.fr.
Anthony
A
Fers-Lidou
Department of Chemistry and Biochemistry, TCU Box 298860, Texas Christian University, Fort Worth, TX 76129, USA. o.berger@tcu.edu.
Olivier
O
Berger
Department of Chemistry and Biochemistry, TCU Box 298860, Texas Christian University, Fort Worth, TX 76129, USA. j.montchamp@tcu.edu.
Jean-Luc
JL
Montchamp
H-phosphinate esters; alcohols; allylation; benzylation; cross-coupling; palladium
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