Polymorphisms in GEMIN4 and AGO1 Genes Are Associated with the Risk of Lung Cancer: A Case-Control Study in Chinese Female Non-Smokers.
MicroRNA biosynthesis genes can affect the regulatory effect of global microRNAs to target mRNA and hence influence the genesis and development of human cancer. Here, we selected five single nucleotide polymorphisms (SNPs) (rs7813, rs2740349, rs2291778, rs910924, rs595961) in two key microRNA biosynthesis genes (GEMIN4 and AGO1) and systematically evaluated the association between these SNPs, the gene-environment interaction and lung cancer risk. To control the impact of cigarette smoking on lung cancer, we recruited Chinese female non-smokers for the study. The total number of lung cancer cases and cancer-free controls were 473 and 395 in the case-control study. Four SNPs showed statistically significant associations with lung cancer risk. After Bonferroni correction, rs7813 and rs595961 were evidently still associated with lung cancer risk. In the stratified analysis, our results revealed that all five SNPs were associated with the risk of lung adenocarcinoma; after Bonferroni correction, significant association was maintained for rs7813, rs910924 and rs595961. Haplotype analysis showed GEMIN4 haplotype C-A-G-T was a protective haplotype for lung cancer. In the combined unfavorable genotype analysis, with the increasing number of unfavorable genotypes, a progressively increased gene-dose effect was observed in lung adenocarcinoma. We also found that individuals exposed to cooking oil fumes showed a relatively high risk of lung cancer, but no interactions were found between cooking oil fume exposure or passive smoking exposure with these SNPs, either on an additive scale or a multiplicative scale. Overall, this is the first study showing that rs7813 and rs595961 could be meaningful as genetic markers for lung cancer risk.
Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110122, China. fangxue222@hotmail.com.|Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang 110122, China. fangxue222@hotmail.com.
Xue
X
Fang
Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110122, China. zhyin@mail.cmu.edu.cn.|Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang 110122, China. zhyin@mail.cmu.edu.cn.
Zhihua
Z
Yin
Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110122, China. xlli@mail.cmu.edu.cn.|Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang 110122, China. xlli@mail.cmu.edu.cn.
Xuelian
X
Li
Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110122, China. xialingzi1013@hotmail.com.|Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang 110122, China. xialingzi1013@hotmail.com.
Lingzi
L
Xia
Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110122, China. bszhou@mail.cmu.edu.cn.|Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang 110122, China. bszhou@mail.cmu.edu.cn.
Baosen
B
Zhou
D000230:Adenocarcinoma; D000077192:Adenocarcinoma of Lung; D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D003296:Cooking / Q000379:methods; D005260:Female; D059647:Gene-Environment Interaction; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012306:Risk; D012907:Smoking
D035683:MicroRNAs
AGO1; GEMIN4; cooking oil fumes; lung cancer; passive smoking; single nucleotide polymorphism; susceptibility
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