Coffee and cancer risk: A meta-analysis of prospective observational studies.
Meta-analyses on coffee and cancer incidence mainly restricted to limited cancers. We carried out a more comprehensive meta-analysis of cohort studies to explore association between coffee and most cancer types. We conducted comprehensive search and summarized relative risk (RR) and 95% confidence intervals for the highest versus lowest coffee intake and cancer using STATA12. We conducted dose-analysis if result suggested significant association. The publication bias was evaluated with begg's and egger's test. Finally, 105 individual prospective studies were included. Inverse associations were observed on oral, pharyngeal, colon, liver, prostate, endometrial cancer and melanoma, with RR 0.69 (95% CI = 0.48-0.99, I2= 73.4%, P = 0.044), 0.87 (95% CI = 0.78-0.96, I2= 28.4%, P = 0.007), 0.46 (95% CI = 0.37-0.57, I2= 0%, P = 0), 0.89 (95% CI = 0.84-0.93, I2= 30.3%, P = 0.003), 0.73 (95% CI = 0.67-0.80, I2= 0%, P = 0) and 0.89 (95% CI = 0.80-0.99, I2= 0%, P = 0.031) respectively. However, the relative risk for lung cancer is 2.18 (95% CI = 1.26-3.75, I2= 63.3%, P = 0.005). The summary relative risk for increment of 2 cups of coffee were RR = 0.73, 95% CI = 0.67-0.79 for liver cancer, RR = 0.97, 95% CI = 0.96-0.98 for prostate cancer and RR = 0.88, 95% CI = 0.85-0.92 for endometrial cancer. Accordingly, coffee intake was associated with reduced risk of oral, pharynx, liver, colon, prostate, endometrial cancer and melanoma and increased lung cancer risk.
Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Anqiang
A
Wang
Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Shanshan
S
Wang
Department of General Surgery, Tianjin Third Central Hospital, Tianjin Institute of Hepatobiliary Disease, Tianjin Key Laboratory of Artificial Cell, Tianjin, China.
Chengpei
C
Zhu
Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Hanchun
H
Huang
Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Liangcai
L
Wu
Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Xueshuai
X
Wan
Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Xiaobo
X
Yang
Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Haohai
H
Zhang
Liver Center and The Transplant Institute, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Ruoyu
R
Miao
Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Lian
L
He
Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Xinting
X
Sang
Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Haitao
H
Zhao
Nutrients. 2011 Nov;3(11):937-50
22254087
Cancer Epidemiol Biomarkers Prev. 2005 Sep;14 (9):2273-4
16172244
Stat Med. 2000 Jul 30;19(14):1831-47
10867674
J Natl Cancer Inst. 2005 Feb 16;97(4):293-300
15713964
Crit Rev Food Sci Nutr. 2006;46(2):101-23
16507475
Am J Epidemiol. 1988 Nov;128(5):1007-15
3189277
Lancet. 1981 Aug 22;2(8243):415
6115175
Int J Cancer. 1997 May 16;71(4):600-4
9178814
Int J Cancer. 2008 Nov 15;123(10):2406-10
18711700
Eur J Cancer Prev. 2015 Jul;24(4):347-52
25325307
Cancer Causes Control. 2008 Dec;19(10):1365-72
18704717
Stat Med. 2002 Jun 15;21(11):1539-58
12111919
Br J Cancer. 2013 Jun 11;108(11):2381-9
23674088
Eur J Clin Nutr. 2010 Sep;64(9):917-23
20571499
Int J Cancer. 2009 Nov 15;125(10):2413-7
19585497
Cancer Causes Control. 2010 Nov;21(11):1941-8
20680436
Int Urol Nephrol. 2014 Aug;46(8):1481-93
24677003
Cancer Causes Control. 2004 Nov;15(9):911-20
15577293
Cancer Causes Control. 2010 Oct;21(10):1533-44
20512657
Ann Oncol. 2012 Feb;23(2):311-8
21746805
Nutr J. 2012 Jun 13;11:42
22695052
Lung Cancer. 2010 Jan;67(1):17-22
19362749
Int J Cancer. 2015 Apr 15;136(8):1899-908
25219573
Nutr Cancer. 2003;45(2):160-7
12881009
Hepatology. 2008 Jul;48(1):129-36
18537182
N Engl J Med. 2001 Mar 1;344(9):632-6
11228277
Biometrics. 1994 Dec;50(4):1088-101
7786990
Ann Epidemiol. 1993 May;3(3):211-6
8275191
Br J Cancer. 2015 Feb 3;112(3):576-9
25535729
J Epidemiol Community Health. 1998 Mar;52(3):166-71
9616421
Cancer Causes Control. 2009 Dec;20(10):2039-44
19597749
Food Chem Toxicol. 2005 Mar;43(3):433-41
15680679
J Epidemiol. 2006 Sep;16(5):185-92
16951537
Nutr Cancer. 2010;62(3):307-21
20358468
Cancer Res. 1989 Apr 1;49(7):1857-60
2924323
Cancer Causes Control. 2001 Apr;12(3):231-8
11405328
Eur J Clin Nutr. 2016 Feb;70(2):199-206
26081490
Pancreas. 2009 Mar;38(2):168-74
18824947
Cancer Epidemiol Biomarkers Prev. 2014 Apr;23(4):638-47
24608187
Cancer Lett. 2006 Dec 8;244(2):260-7
16519996
J Natl Cancer Inst. 2015 Jan 20;107(2):null
25604135
Br J Cancer. 2013 Sep 3;109 (5):1344-51
23880821
Cancer. 2008 Mar 1;112(5):1169-77
18213613
Ann Epidemiol. 2002 Jan;12(1):21-6
11750236
Cancer Epidemiol Biomarkers Prev. 2009 Jun;18(6):1746-53
19505908
Asian J Androl. 2012 May;14(3):365-74
22504869
Cancer Causes Control. 2011 Mar;22(3):503-10
21258859
Int J Cancer. 2005 Aug 10;116(1):150-4
15756689
J Epidemiol. 2005 Jun;15 Suppl 2:S203-11
16127235
Br J Cancer. 2013 Sep 3;109 (5):1352-9
23907431
Br J Cancer. 2013 Oct 1;109(7):1908-13
24022184
Int J Cancer. 2007 Nov 15;121(10):2246-53
17583573
Br J Cancer. 1987 Jun;55(6):687-94
3620314
J Biol Chem. 2005 Jul 29;280(30):27888-95
15944151
Nutr Cancer. 2015;67(3):392-400
25706900
Br J Cancer. 2007 Nov 5;97(9):1291-4
17923877
Int J Cancer. 2013 Apr 1;132(7):1651-9
22886387
Am J Epidemiol. 1993 Sep 15;138(6):380-3
8213743
JAMA. 1992 Sep 23-30;268(12):1573-7
1518112
Am J Clin Nutr. 2012 May;95(5):1172-81
22440851
Breast Cancer Res Treat. 2010 Jun;121(2):461-7
19847643
Int J Cancer. 2000 Apr 1;86(1):132-8
10728607
Int J Cancer. 2012 Oct 1;131(7):1700-10
22190017
Int J Cancer. 2007 Sep 15;121(6):1312-8
17450527
Nutr Cancer. 2007;58(1):22-7
17571963
Clin Gastroenterol Hepatol. 2013 Nov;11(11):1413-1421.e1
23660416
Cancer Epidemiol Biomarkers Prev. 2011 Dec;20(12):2487-95
22109346
Am J Epidemiol. 2013 Jan 1;177(1):50-8
23230042
Br J Cancer. 2011 Jun 28;105(1):157-61
21629248
Int J Cancer. 2012 Aug 15;131(4):E530-6
22021096
Am J Epidemiol. 2006 Apr 1;163(7):638-44
16443798
Cancer Epidemiol Biomarkers Prev. 2001 May;10(5):429-37
11352851
Nutrients. 2014 Sep 18;6(9):3734-46
25237829
Int J Cancer. 2014 Jul 15;135(2):401-12
24318358
N Engl J Med. 1999 May 6;340(18):1390-7
10228189
Cancer Causes Control. 1994 Sep;5(5):401-8
7999961
Epidemiology. 1994 May;5(3):276-82
8038241
Br J Cancer. 2011 Apr 26;104(9):1487-92
21407222
J Natl Cancer Inst. 1986 May;76(5):823-31
3457969
Br J Cancer. 1990 Aug;62(2):267-70
2386741
Br J Cancer. 1999 Dec;81(7):1248-56
10584890
J Epidemiol. 2014;24(5):370-8
24857957
CA Cancer J Clin. 2015 Mar;65(2):87-108
25651787
Eur J Cancer Prev. 2007 Dec;16(6):542-8
18090127
Ann Oncol. 2013 Jul;24(7):1912-8
23508823
Ann Oncol. 2011 Mar;22(3):536-44
20943597
Asian Pac J Cancer Prev. 2004 Jan-Mar;5(1):58-65
15075007
Oncogene. 2000 Nov 23;19(50):5788-800
11126366
Int J Cancer. 2007 Feb 1;120(3):664-71
17096321
Int J Cancer. 2014 Sep 15;135(6):1470-9
24535727
Clin Gastroenterol Hepatol. 2013 Nov;11(11):1486-92
23756220
Nutr Cancer. 2013;65(1):1-16
23368908
Nutr Cancer. 1998;31(1):41-8
9682247
Food Chem Toxicol. 2002 Sep;40(9):1271-310
12204391
J Natl Cancer Inst. 1986 Apr;76(4):587-90
3457196
Int J Epidemiol. 1998 Apr;27(2):173-80
9602395
Am J Epidemiol. 1992 Jun 1;135(11):1301-9
1626547
Int J Cancer. 1988 Jun 15;41(6):794-7
3372055
Oncogene. 2003 Sep 18;22(40):6119-28
13679850
Anticancer Agents Med Chem. 2015;15(4):484-92
25666502
Nature. 1994 Mar 17;368(6468):237-9
7511798
Medicine (Baltimore). 2015 Sep;94(39):e1390
26426606
Cancer Epidemiol Biomarkers Prev. 1997 Dec;6(12):1081-6
9419407
Arch Intern Med. 2008 Oct 13;168(18):2022-31
18852405
Int J Cancer. 2006 Jan 1;118(1):169-73
16003738
Int J Cancer. 2012 Jul 15;131(2):452-60
22020403
BMJ. 2013 Jan 07;346:e8539
23295181
Food Chem Toxicol. 2002 Aug;40(8):1155-63
12067578
Public Health Nutr. 2011 Jul;14(7):1315-20
21466740
Eur J Clin Nutr. 2014 Mar;68(3):330-7
24300907
Int J Cancer. 2006 Nov 1;119(9):2186-9
16841331
Am J Epidemiol. 2009 Apr 15;169(8):954-61
19224978
Cancer Epidemiol Biomarkers Prev. 2015 Feb;24(2):466-71
25662427
J Natl Cancer Inst. 2005 Feb 16;97(4):282-92
15713963
BMJ. 1997 Sep 13;315(7109):629-34
9310563
Cancer Causes Control. 1992 Sep;3(5):403-8
1525320
Int J Cancer. 2002 Mar 20;98(3):480-2
11920604
PLoS Biol. 2010 Mar 30;8(3):e1000344
20361022
Am J Epidemiol. 2008 Dec 15;168(12):1425-32
18974083
Gastroenterology. 2015 Jan;148(1):118-25; quiz e15
25305507
Nutr Cancer. 2014;66(7):1132-43
25181598
CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90
21296855
Eur J Cancer Prev. 2000 Apr;9(2):125-30
10830580
Am J Public Health. 1984 Aug;74(8):820-3
6742274
Am J Epidemiol. 1991 Feb 1;133(3):230-9
2000840
Gut. 2001 Jul;49(1):87-90
11413115
BMC Womens Health. 2014 Mar 25;14:48
24666820
Cancer Sci. 2009 Feb;100(2):294-91
19068095
J Chronic Dis. 1983;36(3):251-6
6826689
Gynecol Oncol. 2013 Jun;129(3):620-9
23535278
BMJ. 2011 Nov 10;343 :d6617
22074852
Nutr Cancer. 2010;62(1):21-9
20043256
Cancer. 2002 Dec 1;95(11):2316-23
12436437
Ann Epidemiol. 2006 Jul;16(7):503-8
16406814
Int J Cancer. 1994 Jul 1;58(1):46-9
8014014
Int J Cancer. 2015 Mar 15;136(6):E720-30
25236393
Cancer Causes Control. 2013 Aug;24(8):1527-34
23681472
Eur J Cancer. 2010 Jul;46(10):1873-81
20395127
BMC Gastroenterol. 2013 Feb 25;13:34
23433483
Am J Clin Nutr. 2012 Aug;96(2):374-81
22695871
Cancer Epidemiol Biomarkers Prev. 2008 Apr;17(4):846-54
18398026
J Epidemiol. 2014;24(2):146-53
24531002
Am J Epidemiol. 2002 May 1;155(9):783-92
11978580
Int J Cancer. 2007 Apr 1;120(7):1542-7
17205519
Int J Cancer. 2008 May 1;122(9):2071-6
18183588