Expression of CDCP1 and ADAM12 in the ovarian cancer microenvironment.
OBJECTIVE
The tumor microenvironment in ovarian cancer (OC) seems to play an important role, and besides tumor cells, biomarkers can derive from endothelial cells. We investigated CDCP1 and ADAM12 expression in relation with other clinical and pathological characteristics in OC patients.


METHODS
We retrospectively evaluated patient files between 2006-2011. A histochemical score was developed to evaluate tumor staining, the microvessel density (MVD), and stromal expression patterns for both ADAM12 and CDCP1. A CD34 antibody was used to assess tumor MVD.


RESULTS
102 patients were selected and 83% had FIGO stage III/IV. A high CDCP1 tumor score correlated significantly with a shorter overall survival (OS) (p<0.01). Cases with positive CDCP1 had an elevated CD34 MVD (p<0.01). An absent/low ADAM12 tumor score correlated with significantly improved OS (p<0.01). Mean CD34 MVD was higher in cases with positive ADAM12 MVD (p=0.012).


CONCLUSIONS
Our results indicate that both tumor markers are negative prognostic factors for overall survival and additional studies are required to validate their future potential.
Department of Surgery, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Catalin
C
Vlad
Paul
P
Kubelac
Andrea
A
Onisim
Bogdan
B
Fetica
Annamaria
A
Fulop
Alexandru
A
Irimie
Patriciu
P
Achimas-Cadariu
D000072199:ADAM12 Protein / Q000235:genetics*; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000235:genetics*; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor / Q000235:genetics; D015815:Cell Adhesion Molecules / Q000235:genetics*; D042783:Endothelial Cells / Q000473:pathology; D005260:Female; D006801:Humans; D055806:Microvessels / Q000473:pathology; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000473:pathology; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D059016:Tumor Microenvironment / Q000235:genetics*
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; C432044:CDCP1 protein, human; D015815:Cell Adhesion Molecules; D009363:Neoplasm Proteins; D000072199:ADAM12 Protein; C000606480:ADAM12 protein, human