Characteristics of number transcoding errors of Chinese- versus English-speaking Alzheimer's disease patients.
Number processing disorder is an acquired deficit in mathematical skills commonly observed in Alzheimer's disease (AD), usually as a consequence of neurological dysfunction. Common impairments include syntactic errors (800012 instead of 8012) and intrusion errors (8 thousand and 12 instead of eight thousand and twelve) in number transcoding tasks. This study aimed to understand the characterization of AD-related number processing disorder within an alphabetic language (English) and ideographical language (Chinese), and to investigate the differences between alphabetic and ideographic language processing. Chinese-speaking AD patients were hypothesized to make significantly more intrusion errors than English-speaking ones, due to the ideographical nature of both Chinese characters and Arabic numbers. A simplified number transcoding test derived from EC301 battery was administered to AD patients. Chinese-speaking AD patients made significantly more intrusion errors (p = 0.001) than English speakers. This demonstrates that number processing in an alphabetic language such as English does not function in the same manner as in Chinese. The impaired inhibition capability likely contributes to such observations due to its competitive lexical representation in brain for Chinese speakers.
a Department of Neurology , Singapore General Hospital , Singapore , Singapore.|b Department of Neurology , National Neuroscience Institute , Singapore , Singapore.
Simon Kang Seng
SK
Ting
a Department of Neurology , Singapore General Hospital , Singapore , Singapore.|b Department of Neurology , National Neuroscience Institute , Singapore , Singapore.
Pei Shi
PS
Chia
c Yong Loo Lin School of Medicine , National University of Singapore , Singapore.
Kevin
K
Kwek
c Yong Loo Lin School of Medicine , National University of Singapore , Singapore.
Wilnard
W
Tan
a Department of Neurology , Singapore General Hospital , Singapore , Singapore.|b Department of Neurology , National Neuroscience Institute , Singapore , Singapore.
Shahul
S
Hameed
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications* / Q000503:physiopathology; D044466:Asian People; D016009:Chi-Square Distribution; D003072:Cognition Disorders / Q000209:etiology*; D005260:Female; D006801:Humans; D007802:Language; D008297:Male; D008433:Mathematics; D008609:Mental Status Schedule; D009483:Neuropsychological Tests; D011340:Problem Solving / Q000502:physiology*
Alzheimer’s disease; acalculia; intrusion error; language; transcoding