Analysis of ovarian reserve markers (AMH, FSH, AFC) in different age strata in IVF/ICSI patients.
BACKGROUND
The predictive roles of follicle stimulating hormone (FSH), anti-mullerian hormone (AMH) and antral follicle count (AFC) as ovarian reserve markers in women with different age groups are not established well.


OBJECTIVE
This study compares the value of FSH, AMH and AFC at the time of in vitro fertilization (IVF) treatment in different age groups.


METHODS
In this cross-sectional study, 103 women aged 20-43 years candidates for IVF/ICSI cycle were recruited. FSH, AMH and AFC on day 3 of menstrual cycle were measured. The relationship of these measured markers with outcome variables (oocytes number, number of frozen/fresh embryo and chemical and clinical pregnancy) was assessed in different age groups (i.e. 20-32, 33-37 and 38-43 years).


RESULTS
our results show that age was correlated with clinical pregnancy, oocyte count and fresh and frozen embryo (p<0.001). AMH, AFC and FSH were not correlated with clinical or chemical pregnancy at total population or age subgroups except the significant correlation of AFC with clinical pregnancy at 33-37 years old group. AFC was correlated with oocyte count and the number of fresh and frozen embryos in the ages group 20-32 years. In this age group, AMH was correlated with fresh and frozen embryos. AMH, AFC and FSH were correlated with oocyte count and the number of fresh embryos in age group 33-37 years. AMH was correlated with oocyte count and the number of fresh embryos in 38-43 years old group.


CONCLUSIONS
We concluded that the age is the superior predictor of IVF outcome and AMH and AFC are variable predicting markers of ovarian reserve in different age groups.
Vali-e-Asr Reproductive Health Research Center, Department of Obstetrics and Gynecology, Imam Khomeini Complex Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Ensieh
E
Shahrokh Tehraninezhad
Vali-e-Asr Reproductive Health Research Center, Department of Obstetrics and Gynecology, Imam Khomeini Complex Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Fatemeh
F
Mehrabi
Vali-e-Asr Reproductive Health Research Center, Department of Obstetrics and Gynecology, Imam Khomeini Complex Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Raheleh
R
Taati
Vali-e-Asr Reproductive Health Research Center, Department of Obstetrics and Gynecology, Imam Khomeini Complex Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Vahid
V
Kalantar
Vali-e-Asr Reproductive Health Research Center, Department of Obstetrics and Gynecology, Imam Khomeini Complex Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Elham
E
Aziminekoo
Vali-e-Asr Reproductive Health Research Center, Department of Obstetrics and Gynecology, Imam Khomeini Complex Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Azam
A
Tarafdari
Anti-mullerian hormone; Follicle stimulating hormone; Ovarian follicles; Ovarian reserve
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