Protein kinase C-mediated sodium glucose transporter 1 activation in precondition-induced cardioprotection.
The concept of cardioprotection through preconditioning against ischemia-reperfusion (I/R) injury is well known and established. However, among different proposed mechanisms regarding the concept of ischemic preconditioning, protein kinase C (PKC)-mediated cardioprotection through ischemic preconditioning plays a key role in myocardial I/R injury. Thus, this study was designed to find the relationship between PKC and sodium glucose transporter 1 (SGLT1) in preconditioning-induced cardioprotection, which is ill reported till now. By applying a multifaceted approach, we demonstrated that PKC activates SGLT1, which curbed oxidative stress and apoptosis against I/R injury. PKC activation enhances cardiac glucose uptake through SGLT1 and seems essential in preventing I/R-induced cardiac injury, indicating a possible cross-talk between PKC and SGLT1.
Division of Medicinal Chemistry and Pharmacology, Indian Institute of Chemical Technology, Hyderabad, India; Drug Discovery Research Center (DDRC), Translational Health Science and Technology Institute (THSTI), Faridabad, Haryana, India.
Abhinav
A
Kanwal
Department of Pharmacology, National Institute of Pharmaceutical Education and Research, Hyderabad, India.
Sujatha
S
Kasetti
Department of Pathology, National Institute of Nutrition, Hyderabad, India.
Uday Kumar
UK
Putcha
Drug Discovery Research Center (DDRC), Translational Health Science and Technology Institute (THSTI), Faridabad, Haryana, India.
Shailendra
S
Asthana
Division of Medicinal Chemistry and Pharmacology, Indian Institute of Chemical Technology, Hyderabad, India; Drug Discovery Research Center (DDRC), Translational Health Science and Technology Institute (THSTI), Faridabad, Haryana, India.
Sanjay K
SK
Banerjee
D004789:Enzyme Activation; D006801:Humans; D009203:Myocardial Infarction / Q000473:pathology* / Q000517:prevention & control; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000503:physiopathology* / Q000517:prevention & control*; D018384:Oxidative Stress; D011493:Protein Kinase C / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction; D051269:Sodium-Glucose Transporter 1 / Q000737:chemistry / Q000378:metabolism*
D051269:Sodium-Glucose Transporter 1; D011493:Protein Kinase C
SGLT1; ischemia-reperfusion injury; ischemic preconditioning; oxidative stress; phlorizin; phorbol-12-myristate
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