Analyses of prognosis-related factors of intracranial solitary fibrous tumors and hemangiopericytomas help understand the relationship between the two sorts of tumors.
Increasing evidence has suggested a close relationship between solitary fibrous tumors (SFTs) and hemangiopericytomas (HPCs) in the central nervous system (CNS). However, CNS SFTs differentiate from HPCs in their clinical behavior and patient prognoses. Analyses of prognosis-related factors can help clarify the relationship between SFT and HPC. The intracranial SFT and HPC cases treated in our departments from January 2002 to December 2012 were retrospectively reviewed. The SFT and HPC cases were also combined into an SFT/HPC group. The factors associated with patient progression-free survival (PFS) and overall survival (OS) were statistically analyzed using uni- and multivariate analyses. Fifty-eight intracranial SFT/HPC patients including 38 SFT patients and 20 HPC patients were treated during this period. The "Marseille grading" evaluated upon the histological aggressive phenotypes was applied in this study. The grading reflected a malignant progression ranging from "conventional" SFTs (grade I) to WHO III HPCs (grade III), and grade was negatively correlated with the PFS and OS of the SFT, HPC and SFT/HPC patients (P < 0.05).The multivariate analyses revealed that gross total resection (GTR) was significantly positively correlated with PFS and OS in the SFT, HPC and SFT/HPC patients and that radiotherapy was significantly positively correlated with PFS in the HPC and SFT/HPC patients (P < 0.05). In conclusion, the intracranial SFTs and HPCs share common prognostic factors including extent of surgery and pathology, moreover, the histological grading of the aggressive phenotypes supports the unifying of the CNS SFT and HPC into one tumor entity of SFT/HPC.
Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Lingcheng
L
Zeng
Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Yan
Y
Wang
Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Yu
Y
Wang
Department of Neurosurgery, Guanggu Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Lin
L
Han
Department of Neurosurgery, Caidian Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Hongquan
H
Niu
Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Mengxian
M
Zhang
Department of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. kecs@hust.edu.cn.
Changshu
C
Ke
Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. 29782315@qq.com.
Jian
0000-0002-8987-5940
J
Chen
Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Ting
T
Lei
D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D016543:Central Nervous System Neoplasms / Q000175:diagnosis* / Q000401:mortality; D005260:Female; D006393:Hemangiopericytoma / Q000175:diagnosis* / Q000378:metabolism / Q000401:mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D054364:Solitary Fibrous Tumors / Q000175:diagnosis* / Q000378:metabolism / Q000401:mortality; D013997:Time Factors; D055815:Young Adult
D014408:Biomarkers, Tumor
Central nervous system; Hemangiopericytoma; Prognosis; Solitary fibrous tumors
Nat Genet. 2013 Feb;45(2):131-2
23313954
Histopathology. 2006 Jan;48(1):63-74
16359538
Int J Surg Pathol. 2011 Aug;19(4):476-86
21878477
Am J Pathol. 2014 Apr;184(4):1209-18
24513261
Neurosurgery. 2011 Oct;69(4):E1023-8; discussion E1028
21593698
Brain Pathol. 2012 Jul;22(4):511-21
22082190
Adv Anat Pathol. 2016 Mar;23 (2):104-11
26849816
Adv Anat Pathol. 2011 Sep;18(5):356-92
21841406
Int J Surg Pathol. 2016 Jun;24(4):281-92
26811389
Nat Genet. 2013 Feb;45(2):180-5
23313952
J Clin Neurosci. 2014 Apr;21(4):612-5
24231562
Virchows Arch. 2010 Apr;456(4):343-54
20165866
Neurosurgery. 2005 Jun;56(6):E1378; discussion E1378
15918957
Acta Neurochir (Wien). 2012 Feb;154(2):237-48; discussion 248
21938461
J Neuropathol Exp Neurol. 2016 Mar;75(3):263-71
26883114
Clin Neurol Neurosurg. 2009 Jan;111(1):34-8
18922629
World Neurosurg. 2014 Mar-Apr;81(3-4):556-62
24239740
Clin Neurol Neurosurg. 2011 Nov;113(9):703-10
21872387
Pathol Int. 2011 Mar;61(3):143-9
21355956
Acta Neuropathol. 2013 May;125(5):651-8
23575898