'Cold cuts' added to the circadian smorgasbord of regulatory mechanisms.
In mammals, rhythms in body temperature help to entrain and synchronize circadian rhythms throughout the organism, and the cold-inducible RNA-binding protein (CIRBP) is one of the mediators of these daily temperature changes. Cirbp mRNA expression is regulated by the daily subtle rhythms in body temperature, and a new study by Gotic and colleagues (pp. 2005-2017) reveals a surprising and novel mechanism that involves temperature-dependent enhancement of splicing efficiency.
University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Carla B
CB
Green
D000818:Animals; D002940:Circadian Rhythm / Q000235:genetics*; D003080:Cold Temperature; D012326:RNA Splicing; D013696:Temperature
Cirbp; circadian rhythms; splicing efficiency; temperature
BMC Biotechnol. 2012 Oct 10;12:72
23046908
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20947768
PLoS One. 2011;6(9):e24521
21915348
Genes Dev. 2012 Mar 15;26(6):567-80
22379191
Genes Dev. 2008 Feb 1;22(3):331-45
18245447
PLoS Biol. 2007 Feb;5(2):e34
17298173
Science. 2012 Oct 19;338(6105):379-83
22923437
Curr Biol. 2002 Sep 17;12(18):1574-83
12372249
Genes Dev. 2016 Sep 1;30(17):2005-17
27633015