NRAS, NRAS, Which Mutation Is Fairest of Them All?
In 28% of melanomas, NRAS is mutated in one of two hotspots: G12 or Q61. Phosphoproteomic analysis of primary human melanocytes transduced with G12 and Q61 showed different phosphorylation events in the phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) pathways. Surprisingly, NRAS(G12) modulates the PI3K pathway and overexpresses the kinase PIM2, whereas NRAS(Q61) is associated with the MAPK pathway and overexpression of CK2α.
Institut Curie, Paris Sciences et Lettres Research University, Institut National de la Santé et de la Recherche Médicale U1021, Normal and Pathological Development of Melanocytes, Orsay, France; Université Paris-Sud, Université Paris-Saclay, Centre National de la Recherche Scientifique Unité Mixte de Recherche 3347, Orsay, France; Equipe Labellisée Ligue Contre le Cancer, Orsay, France.
Christine
C
Grill
Institut Curie, Paris Sciences et Lettres Research University, Institut National de la Santé et de la Recherche Médicale U1021, Normal and Pathological Development of Melanocytes, Orsay, France; Université Paris-Sud, Université Paris-Saclay, Centre National de la Recherche Scientifique Unité Mixte de Recherche 3347, Orsay, France; Equipe Labellisée Ligue Contre le Cancer, Orsay, France. Electronic address: lionel.larue@curie.fr.
Lionel
L
Larue
D006801:Humans; D008544:Melanocytes; D008545:Melanoma / Q000235:genetics*; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics; D009154:Mutation; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics*; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics
D019869:Phosphatidylinositol 3-Kinases; D048493:Proto-Oncogene Proteins B-raf; D020928:Mitogen-Activated Protein Kinases