New lanostane-type triterpenoids from the fruiting body of Ganoderma hainanense.
Five new lanostane-type triterpenoids, ganoderenses A-E (1-5), two new lanostane nor-triterpenoids, ganoderenses F and G (6 and 7), along with 13 known analogues (8-20) were isolated from the fruiting body of Ganoderma hainanense. Their structures were determined by combined chemical and spectral methods, and the absolute configurations of compounds 1 and 13 were confirmed by single crystal X-ray diffraction. All compounds were evaluated for inhibitory activity against thioredoxin reductase (TrxR), a potential target for cancer chemotherapy with redox balance and antioxidant functions, but were inactive.
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China.
Wei
W
Li
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China.
Lan-Lan
LL
Lou
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China.
Jian-Yong
JY
Zhu
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China.
Jun-Sheng
JS
Zhang
School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China.
An-An
AA
Liang
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China.
Jing-Mei
JM
Bao
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China. Electronic address: tanggh5@mail.sysu.edu.cn.
Gui-Hua
GH
Tang
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China.
Sheng
S
Yin
D018360:Crystallography, X-Ray; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D032902:Ganoderma / Q000737:chemistry*; D015394:Molecular Structure; D013880:Thioredoxin-Disulfide Reductase / Q000037:antagonists & inhibitors*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification
D014315:Triterpenes; D013880:Thioredoxin-Disulfide Reductase
Ganoderma hainanense; Lanostane-type triterpenoids; Nor-triterpenoids