Magnetic Nanoparticles for Hepatocellular Carcinoma Diagnosis and Therapy.
Hepatocellular carcinoma (HCC) is the most common primary tumor of the liver, ranking as the second most common cause of death from cancer worldwide. Magnetic nanoparticles (MNPs) have been used so far in tumor diagnosis and treatment, demonstrating great potential and promising results. In principle, three different approaches can be used in the treatment of tumors with superparamagnetic iron oxide nanoparticles: magnetically induced hyperthermia, drug targeting and selective suppression of tumor growth. This review focuses on the use of iron oxide nanoparticles for the diagnosis and treatment of liver cancer and offers a walkthrough from the MNPs imaging applicability to further therapeutic options, including their potential flaws. The MNP unique physical and biochemical properties will be mentioned in close relationship to their subsequent effects on the human body, and, also, their toxic potential will be noted. A presentation of what barriers the MNPs should overcome to be more successful will conclude this review.
Research Center of Gastroenterology and Hepatology of Craiova, Craiova, Romania. bogdan.ungureanu@umfcv.ro.
Bogdan Silviu
BS
Ungureanu
National Institute of Material Physics, Magurele, Romania.
Cristian-Mihail
CM
Teodorescu
Research Center of Gastroenterology and Hepatology of Craiova, Craiova, Romania; Department of Endoscopy, Gastrointestinal Unit, Copenhagen University Herlev Hospital, Copenhagen, Denmark.
Adrian
A
Săftoiu
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000188:drug therapy*; D003287:Contrast Media / Q000008:administration & dosage; D004337:Drug Carriers; D004339:Drug Compounding; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D058185:Magnetite Nanoparticles; D025202:Molecular Diagnostic Techniques; D050997:Nanomedicine / Q000379:methods*; D011237:Predictive Value of Tests
D000970:Antineoplastic Agents; D003287:Contrast Media; D004337:Drug Carriers; D058185:Magnetite Nanoparticles