Granular IgM Deposition at Basement Membrane Zone in an Infant with Diffuse Cutaneous Mastocytosis.
Diffuse Cutaneous mastocytosis (DCM) occurs due to abnormal accumulation of mast cells in the skin. We report an 8-month-old infant presented papulovesicular lesions, predominantly on the trunk. Skin biopsy revealed subepidermal bulla, interspersed with mast cells, eosinophils and neutrophils. Direct immunofluorescence microscopy of perilesional skin revealed nonspecific deposition of IgM in granular pattern along the dermoepidermal junction.
Department of Dermatology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
Subramanian
S
Kumudhini
Department of Dermatology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
Raghavendra
R
Rao
Department of Pathology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
Gauri
G
Salgaonkar
Department of Dermatology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
Sricharith
S
Shetty
Department of Dermatology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
Sathish
S
Pai
Diffuse cutaneous mastocytosis; granular IgM deposition; vesiculobullous lesions
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