Effect of Experimental Cutaneous Hand Pain on Corticospinal Excitability and Short Afferent Inhibition.
Sensorimotor integration is altered in people with chronic pain. While there is substantial evidence that pain interferes with neural activity in primary sensory and motor cortices, much less is known about its impact on integrative sensorimotor processes. Here, the short latency afferent inhibition (SAI) paradigm was used to assess sensorimotor integration in the presence and absence of experimental cutaneous heat pain applied to the hand. Ulnar nerve stimulation was combined with transcranial magnetic stimulation to condition motor evoked potentials (MEPs) in the first dorsal interosseous muscle. Four interstimulus intervals (ISI) were tested, based on the latency of the N20 component of the afferent sensory volley (N20-5 ms, N20+2 ms, N20+4 ms, N20+10 ms). In the PAIN condition, MEPs were smaller compared to the NEUTRAL condition (p= 0.005), and were modulated as a function of the ISI (p= 0.012). Post-hoc planned comparisons revealed that MEPs at N20+2 and N20+4 were inhibited compared to unconditioned MEPs. However, the level of inhibition (SAI) was similar in the PAIN and NEUTRAL conditions. This suggests that the interplay between pain and sensorimotor integration is not mediated through direct and rapid pathways as assessed by SAI, but rather might involve higher-order integrative areas.
Center for Interdisciplinary Research in Rehabilitation and Social Integration, Québec, QC G1M 2S8, Canada. catherine.mercier@rea.ulaval.ca.|Department of Rehabilitation, Laval University, Québec, QC G1V 0A6, Canada. catherine.mercier@rea.ulaval.ca.
Catherine
C
Mercier
Center for Interdisciplinary Research in Rehabilitation and Social Integration, Québec, QC G1M 2S8, Canada. martin.gagne.77@gmail.com.
Martin
M
Gagné
ImpAct Team, Lyon Neuroscience Research Center, INSERM U1028, CNRS UMR5292, Bron 69500, France. karen.reilly@inserm.fr.|University Claude Bernard Lyon 1, Lyon F-69000, France. karen.reilly@inserm.fr.
Karen T
KT
Reilly
Center for Interdisciplinary Research in Rehabilitation and Social Integration, Québec, QC G1M 2S8, Canada. laurent.bouyer@rea.ulaval.ca.|Department of Rehabilitation, Laval University, Québec, QC G1V 0A6, Canada. laurent.bouyer@rea.ulaval.ca.
Laurent J
LJ
Bouyer
motor cortex; nociception; sensorimotor integration; transcranial magnetic stimulation; ulnar nerve
Semin Arthritis Rheum. 2010 Dec;40(3):250-66
19954822
J Neurophysiol. 1997 May;77(5):2446-65
9163369
PM R. 2011 Dec;3(12):1116-25
22192321
Brain Res. 2013 Apr 4;1504:58-73
23396112
Exp Brain Res. 2009 Feb;193(2):267-74
18974984
Pain. 2016 Mar;157(3):516-29
26588692
J Pain. 2013 Oct;14(10):1001-18
23726046
Pain Med. 2016 Feb 13;:null
26874884
Clin Neurophysiol. 2011 Nov;122(11):2318-23
21601513
Cereb Cortex. 2013 Aug;23(8):1942-51
22744704
Brain. 2012 Feb;135(Pt 2):582-95
22345089
J Pain. 2013 Nov;14(11):1270-88
24035350
Rheumatology (Oxford). 2005 Apr;44(4):509-16
15644392
Neurosci Lett. 1998 Jun 5;248(3):155-8
9654332
PLoS One. 2015 Nov 24;10(11):e0142857
26599632
J Pain. 2012 Feb;13(2):187-94
22227117
J Neurophysiol. 2011 Feb;105(2):749-56
21148098
Exp Brain Res. 2001 Jul;139(2):168-72
11497058
Eur J Pain. 2014 Aug;18(7):897-9
25045000
J Physiol. 2005 Nov 15;569(Pt 1):315-23
16141274
Clin Neurophysiol. 2016 Jan;127(1):769-78
25900020
Arthritis Res Ther. 2014 Dec 10;16(6):502
25497133
J Physiol. 2008 Mar 1;586(5):1277-89
17884925
Clin Neurophysiol. 2001 Sep;112(9):1633-41
11514246
Pain. 2016 Aug;157(8):1682-95
27023419
Lancet. 1999 Oct 23;354(9188):1464-6
10543687
J Comp Neurol. 1992 Jul 15;321(3):373-86
1506475
Exp Brain Res. 2009 Nov;199(2):177-83
19730839
Exp Brain Res. 2014 Sep;232(9):2879-89
24820288
Eur J Pain. 2016 Sep;20(8):1203-13
26913474
Cereb Cortex. 2016 May;26(5):1878-90
25609242
J Neurophysiol. 2012 Jun;107(11):3190-9
22442568
Rheumatology (Oxford). 2012 Aug;51(8):1492-9
22525161
Neuroscience. 2009 Aug 4;162(1):78-86
19406214
Neuroscience. 2007 Nov 30;150(1):72-81
17976921
Rheumatology (Oxford). 2014 Jul;53(7):1194-9
24591698
J Pain. 2016 Feb;17 (2):167-80
26552501
Neurosci Lett. 2001 Nov 13;314(1-2):97-101
11698155
J Physiol. 2011 Jun 15;589(Pt 12):2955-62
21540341
Psychophysiology. 1999 May;36(3):371-8
10352561
Brain Stimul. 2011 Oct;4(4):202-9
22032735
Pain. 2007 Feb;127(3):270-5
17011705
Brain. 2006 Aug;129(Pt 8):2211-23
16799174
Rheumatology (Oxford). 2007 Oct;46(10):1587-92
17767000
Exp Brain Res. 2010 May;203(1):31-8
20232062
Clin Neurophysiol. 2003 Jul;114(7):1351-8
12842734
J Neurophysiol. 2016 Nov 1;116(5):2210-2220
27535371
BMC Musculoskelet Disord. 2015 Feb 12;16:25
25887644
J Physiol. 2000 Mar 1;523 Pt 2:503-13
10699092
Clin Neurophysiol. 1999 Aug;110(8):1475-80
10454286