Ossicular Bone Damage and Hearing Loss in Rheumatoid Arthritis: A Correlated Functional and High Resolution Morphometric Study in Collagen-Induced Arthritic Mice.
Globally, a body of comparative case-control studies suggests that rheumatoid arthritis (RA) patients are more prone to developing hearing loss (HL). However, experimental evidence that supports this hypothesis is still lacking because the human auditory organ is not readily accessible. The aim of this study was to determine the association between bone damage to the ossicles of the middle ear and HL, using a widely accepted murine model of collagen-induced arthritis (RA mice). Diarthrodial joints in the middle ear were examined with microcomputer tomography (microCT), and hearing function was assessed by auditory brainstem response (ABR). RA mice exhibited significantly decreased hearing sensitivity compared to age-matched controls. Additionally, a significant narrowing of the incudostapedial joint space and an increase in the porosity of the stapes were observed. The absolute latencies of all ABR waves were prolonged, but mean interpeak latencies were not statistically different. The observed bone defects in the middle ear that were accompanied by changes in ABR responses were consistent with conductive HL. This combination suggests that conductive impairment is at least part of the etiology of RA-induced HL in a murine model. Whether the inner ear sustains bone erosion or other pathology, and whether the cochlear nerve sustains pathology await subsequent studies. Considering the fact that certain anti-inflammatories are ototoxic in high doses, monitoring RA patients' auditory function is advisable as part of the effort to ensure their well-being.
Department of Microbiology and Immunology, Lewis Katz School of Medicine-Temple University, Philadelphia, PA, 19140, United States of America.
Rensa
R
Chen
Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, 08854, United States of America.
Martin
M
Schwander
Department of Anatomy, Lewis Katz School of Medicine-Temple University, Philadelphia, PA, 19140, United States of America.
Mary F
MF
Barbe
Department of Microbiology and Immunology, Lewis Katz School of Medicine-Temple University, Philadelphia, PA, 19140, United States of America.
Marion M
http://orcid.org/0000-0003-1706-2964
MM
Chan
D000818:Animals; D001169:Arthritis, Experimental / Q000473:pathology*; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000473:pathology*; D003094:Collagen / Q000633:toxicity*; D004429:Ear Ossicles / Q000473:pathology*; D006309:Hearing; D034381:Hearing Loss / Q000150:complications / Q000473:pathology*; D051379:Mice; D008811:Mice, Inbred DBA; D012684:Sensory Thresholds; D055114:X-Ray Microtomography
D003094:Collagen
J Immunol. 2010 Jun 1;184(11):6418-26
20435922
Hear Res. 1999 Apr;130(1-2):94-107
10320101
J Otolaryngol. 2001 Oct;30(5):289-94
11771022
Curr Protoc Neurosci. 2006 Feb;Chapter 8:Unit8.21B
18428645
Rheumatol Int. 2002 May;22(1):16-9
12120906
Clin Rheumatol. 2008 May;27(5):637-40
18071780
Acta Med Iran. 2010 Nov-Dec;48(6):371-3
21287475
Eur Arch Otorhinolaryngol. 2009 Nov;266(11):1719-26
19360433
Auris Nasus Larynx. 2007 Sep;34(3):307-11
17157467
Am J Otol. 1988 Nov;9(6):465-9
3232717
Acta Otolaryngol. 1995 Mar;115(2):251-4
7610815
Am J Otolaryngol. 1985 May-Jun;6(3):209-16
3874564
Am J Otolaryngol. 2004 Nov-Dec;25(6):411-7
15547810
Ann Rheum Dis. 1984 Aug;43(4):658-9
6476926
Z Rheumatol. 1980 Mar-Apr;39(3-4):91-4
7424204
J Bone Miner Res. 2013 Apr;28(4):794-806
23090909
Prog Neurobiol. 2000 Dec;62(6):583-631
10880852
APMIS. 1989 Jul;97(7):575-84
2665798
J Otolaryngol. 1990 Apr;19(2):100-2
2348502
J Laryngol Otol. 1995 Aug;109(8):713-8
7561491
Vestn Otorinolaringol. 2015;(1):25-7
25909669
Otol Neurotol. 2011 Jan;32(1):e5-6
20142795
Anat Histol Embryol. 2009 Aug;38(4):311-5
19519734
Int J Pediatr Otorhinolaryngol. 2007 Jul;71(7):1079-85
17482280
Indian J Otolaryngol Head Neck Surg. 2013 Dec;65(Suppl 3):493-7
24427703
Audiology. 1997 May-Jun;36(3):136-46
9193731
Otolaryngol Pol. 2007;61(6):972-8
18546945
Clin Exp Rheumatol. 1990 Sep-Oct;8(5):487-90
2261709
Otol Neurotol. 2005 Jul;26(4):755-61
16015180
ORL J Otorhinolaryngol Relat Spec. 2007;69(4):233-8
17409782
Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5252-7
19270079
Ann Rheum Dis. 1978 Dec;37(6):522-4
312056
Hear Res. 2010 May;263(1-2):93-103
19835942
Laryngoscope. 2005 Jan;115(1):147-54
15630384
Curr Protoc Immunol. 2010 Apr;Chapter 15:Unit 15.5.1-25
20376842
Clin Otolaryngol Allied Sci. 2004 Feb;29(1):75-9
14961856
Ann Otol Rhinol Laryngol Suppl. 1984 Sep-Oct;113:3-5
6435495
Nature. 2003 May 15;423(6937):356-61
12748655
Am J Otol. 1996 Jan;17(1):69-75
8694137
Auris Nasus Larynx. 2014 Oct;41(5):417-21
24933709
Clin Exp Rheumatol. 1996 May-Jun;14(3):243-7
8809437
Laryngoscope. 2003 Feb;113(2):312-5
12567088
J Rheumatol. 1986 Oct;13(5):878-81
3820196
Arthritis Res Ther. 2015 Mar 09;17:50
25889786
Acta Otorrinolaringol Esp. 2007 Jun-Jul;58(6):232-8
17663942
J Assoc Res Otolaryngol. 2003 Jun;4(2):250-63
12943376
Ann Rheum Dis. 1990 Aug;49(8):620-3
2396868
Otol Neurotol. 2010 Sep;31(7):1109-14
20657333
Laryngoscope. 2006 Nov;116(11):2044-9
17075400
Exp Gerontol. 2015 Dec;72 :204-17
26517953
ISRN Rheumatol. 2011;2011:208627
22482066