Discrepancy in Vancomycin AUC/MIC Ratio Targeted Attainment Based upon the Susceptibility Testing in Staphylococcus aureus.
This study demonstrated a statistically significant difference in vancomycin minimum inhibitory concentration (MIC) forStaphylococcus aureusbetween a common automated system (Vitek 2) and the E-test method in patients withS. aureusbloodstream infections. At an area under the serum concentration time curve (AUC) threshold of 400 mg∙h/L, we would have reached the current Infectious Diseases Society of America (IDSA)/American Society of Health System Pharmacists (ASHP)/Society of Infectious Diseases Pharmacists (SIDP) guideline suggested AUC/MIC target in almost 100% of patients while using the Vitek 2 MIC data; however, we could only generate 40% target attainment while using E-test MIC data (p< 0.0001). An AUC of 450 mg∙h/L or greater was required to achieve 100% target attainment using either Vitek 2 or E-test MIC results.
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA. eumxx005@umn.edu.
Seenae
S
Eum
Department of Lab Microbiology, Regions Hospital, Saint Paul, MN 55101, USA. Robert.L.Bergsbaken@healthpartners.com.
Robert L
RL
Bergsbaken
Department of Pharmacy, Regions Hospital, Saint Paul, MN 55101, USA. Craig.L.Harvey@healthpartners.com.
Craig L
CL
Harvey
Department of Medicine, Regions Hospital, Saint Paul, MN 55101, USA. J.B.Warren@healthpartners.com.
J Bryan
JB
Warren
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA. rotsc001@umn.edu.
John C
JC
Rotschafer
MIC; Staphylococcus aureus; susceptibility testing; vancomycin
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