Impact of Reconstruction Algorithms and Gender-Associated Anatomy on Coronary Calcium Scoring with CT: An Anthropomorphic Phantom Study.
Different computed tomography imaging protocols and patient characteristics can impact the accuracy and precision of the calcium score and may lead to inconsistent patient treatment recommendations. The aim of this work was to determine the impact of reconstruction algorithm and gender characteristics on coronary artery calcium scoring based on a phantom study using computed tomography.



Four synthetic heart vessels with vessel diameters corresponding to female and male left main and left circumflex arteries containing calcification-mimicking materials (200-1000 HU) were inserted into a thorax phantom and were scanned with and without female breast plates (male and female phantoms, respectively). Ten scans were acquired and were reconstructed at 3-mm slices using filtered-back projection (FBP) and iterative reconstruction with medium and strong denoising (IR3 and IR5) algorithms. Agatston and calcium volume scores were estimated for each vessel. Calcium scores for each vessel and the total calcium score (summation of all four vessels) were compared between the two phantoms to quantify the impact of the breast plates and reconstruction parameters. Calcium scores were also compared among vessels of different diameters to investigate the impact of the vessel size.



The calcium scores were significantly larger for FBP reconstruction (FBP > IR3>IR5). Agatston scores (calcium volume score) for vessels in the male phantom scans were on average 4.8% (2.9%), 8.2% (7.1%), and 10.5% (9.4%) higher compared to those in the female phantom with FBP, IR3, and IR5, respectively, when exposure was conserved across phantoms. The total calcium scores from the male phantom were significantly larger than those from the female phantom (P <0.05). In general, calcium volume scores were underestimated (up to about 50%) for smaller vessels, especially when scanned in the female phantom.



Calcium scores significantly decreased with iterative reconstruction and tended to be underestimated for female anatomy (smaller vessels and presence of breast plates).
U.S. Food and Drug Administration, CDRH/OSEL/DIDSR, 10903 New Hampshire Ave., Bldg. 62 Rm. 4110, Silver Spring, MD 20993. Electronic address: qin.li1@fda.hhs.gov.
Qin
Q
Li
U.S. Food and Drug Administration, CDRH/OIR/DRH, Silver Spring, Maryland.
Songtao
S
Liu
U.S. Food and Drug Administration, CDRH/OSEL/DIDSR, 10903 New Hampshire Ave., Bldg. 62 Rm. 4110, Silver Spring, MD 20993.
Kyle J
KJ
Myers
U.S. Food and Drug Administration, CDRH/OSEL/DIDSR, 10903 New Hampshire Ave., Bldg. 62 Rm. 4110, Silver Spring, MD 20993.
Marios A
MA
Gavrielides
U.S. Food and Drug Administration, CDRH/OSEL/DIDSR, 10903 New Hampshire Ave., Bldg. 62 Rm. 4110, Silver Spring, MD 20993.
Rongping
R
Zeng
U.S. Food and Drug Administration, CDRH/OSEL/DIDSR, 10903 New Hampshire Ave., Bldg. 62 Rm. 4110, Silver Spring, MD 20993.
Berkman
B
Sahiner
U.S. Food and Drug Administration, CDRH/OSEL/DIDSR, 10903 New Hampshire Ave., Bldg. 62 Rm. 4110, Silver Spring, MD 20993.
Nicholas
N
Petrick
D000465:Algorithms; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D019047:Phantoms, Imaging; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods; D015203:Reproducibility of Results; D059629:Signal-To-Noise Ratio; D014057:Tomography, X-Ray Computed / Q000379:methods; D061205:Vascular Calcification / Q000000981:diagnostic imaging*
Coronary calcium scoring; computed tomography; coronary imaging; gender differences; phantom study; quantitative imaging
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