Co-transfer of blaNDM-5and mcr-1 by an IncX3-X4 hybrid plasmid in Escherichia coli.
Carbapenem and colistin are the last-resort antibiotics used for treating multidrug-resistant Gram-negative pathogens. Here, we report, for the first time, co-transfer of resistance to both classes of antibiotics by a mobile IncX3-X4 hybrid plasmid in an Escherichia coli isolate. Spread of such a plasmid is of great concern for clinical therapy, and heightened efforts are needed to control its dissemination.
National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou 510642, China.|College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Jian
J
Sun
National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou 510642, China.|College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Run-Shi
RS
Yang
Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA.
Qijing
Q
Zhang
Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Zhejiang 310027, China.
Youjun
Y
Feng
National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou 510642, China.|College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Liang-Xing
LX
Fang
National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou 510642, China.|College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Jing
J
Xia
National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou 510642, China.|College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Liang
L
Li
National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou 510642, China.|College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Xiao-Yue
XY
Lv
National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou 510642, China.|College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Jia-Hong
JH
Duan
National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou 510642, China.|College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Xiao-Ping
XP
Liao
National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou 510642, China.|College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.|Jiangsu Co-Innovation Centre for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu 225009, China.
Ya-Hong
YH
Liu