Urinary Tract Infection: Pathogenesis and Outlook.
The clinical syndromes comprising urinary tract infection (UTI) continue to exert significant impact on millions of patients worldwide, most of whom are otherwise healthy women. Antibiotic therapy for acute cystitis does not prevent recurrences, which plague up to one fourth of women after an initial UTI. Rising antimicrobial resistance among uropathogenic bacteria further complicates therapeutic decisions, necessitating new approaches based on fundamental biological investigation. In this review, we highlight contemporary advances in the field of UTI pathogenesis and how these might inform both our clinical perspective and future scientific priorities.
Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA; Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, USA.
Lisa K
LK
McLellan
Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: dhunstad@wustl.edu.
David A
DA
Hunstad
D000208:Acute Disease; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000150:complications* / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D003556:Cystitis / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D012008:Recurrence; D055502:Secondary Prevention / Q000379:methods; D014551:Urinary Tract / Q000187:drug effects / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000453:epidemiology* / Q000276:immunology / Q000473:pathology
D000900:Anti-Bacterial Agents
Escherichia coli; cystitis; pyelonephritis; urinary tract infection
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