Osteopetrosis (Marble Bone Disease): A Rare Disease in Children.
Osteopetrosis is a group of diseases that affects the growth and remodeling of bone and characterized by over growth and sclerosis of bone, with thickening of the bony cortices, abnormal dental development and narrowing of the marrow cavities throughout the skeleton. It is an uncommon disease of unknown cause. A 5-year-old boy was suffering from infantile (severe form) osteopetrosis with cardiac enlargement, severe anemia, hepatosplenomagaly and radiographs showed generalized increase in bone density (chalky white), narrowing of skull base is reported here.
Former Professor and Head, Department of Pedodontics and Preventive Dentistry, SJM Dental College and Hospital Chitradunga, Karnataka, India.
Raghunath
R
Reddy Mh
Albers-Schonberg disease.; Marble bone disease; Osteopetrosis; Osteopetrosis tarda
Am J Anat. 1982 Feb;163(2):157-67
7072615
J Bone Joint Surg Br. 1948 May;30B(2):339-56
18861074
Acta Paediatr. 1962 Sep;51:585-8
13985134
Postgrad Med J. 1977 Aug;53(622):507-16
335376
N Engl J Med. 1995 Jun 15;332(24):1594-9
7753137
N Engl J Med. 1980 Mar 27;302(13):701-8
6986555
J Pediatr. 1977 Jul;91(1):43-7
874663