DNA methylation alterations in the pathogenesis of lupus.
Although lupus is, by definition, associated with genetic and immunological factors, its molecular mechanisms remain unclear. The up-to-date research findings point out that various genetic and epigenetic factors, especially gene-specific and site-specific methylation, are believed to contribute to the initiation and development of systemic lupus erythematosus (SLE). This review presents and summarizes the association between abnormal DNA methylation of immune-related cells and lupus-like diseases, as well as the possible mechanisms of immune disorder caused by DNA methylation, aiming at a better understanding of the roles of aberrant DNA methylation in the initiation and development of certain forms of lupus and providing a new insight into promising therapeutic regimens in lupus-like diseases.
Department of Oncology, Changsha Central Hospital, Changsha, China.
S H
SH
Chen
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.
Q L
QL
Lv
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.
L
L
Hu
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.
M J
MJ
Peng
Department of Oncology, Changsha Central Hospital, Changsha, China.
G H
GH
Wang
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.
B
B
Sun
D000818:Animals; D015551:Autoimmunity; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*
DNA methylation; immune-related cells; lupus-like diseases; systemic lupus erythematosus
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