ADH1B and CDH1 polymorphisms predict prognosis in male patients with non-metastatic laryngeal cancer.
In this study, we assessed the association between single nucleotide polymorphisms (SNPs) in candidate genes and the prognosis of laryngeal cancer (LC) patients. Thirty-seven SNPs in 26 genes were genotyped in 170 male Han Chinese patients with LC. The effects of the candidate genes on the prognosis of LC patients were evaluated using Kaplan-Meier curves and Cox proportional hazards regression models. The GA genotype of rs1229984 (hazard ratio [HR], 0.537; 95% confidence interval [CI], 0.340-0.848; p = 0.008) in alcohol dehydrogenase 1B (ADH1B), and the AA genotype of rs9929218 (HR, 6.074; 95% CI, 1.426-25.870; p = 0.015) in CDH1 were associated with overall survival. Our data suggest that polymorphisms in ADH1B and CDH1 may be prognostic indicators in LC.
Department of Stomatology, First Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi 710061, China.
Daxu
D
Li
Department of Stomatology, Ankang Central Hospital, Ankang 725000, Shaanxi.
Ruizhi
R
Zhang
School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China.
Tianbo
T
Jin
School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China.
Na
N
He
Department of Stomatology, First Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi 710061, China.
Le
L
Ren
Department of Stomatology, First Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi 710061, China.
Zhe
Z
Zhang
Department of Stomatology, First Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi 710061, China.
Qingna
Q
Zhang
Department of Stomatology, First Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi 710061, China.
Ran
R
Xu
Department of Stomatology, First Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi 710061, China.
Hong
H
Tao
Department of Plastic and Burn Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710038, China.
Guang
G
Zeng
State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
Jing
J
Gao
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000483:Alleles; D015703:Antigens, CD; D015820:Cadherins / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053208:Kaplan-Meier Estimate; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D016016:Proportional Hazards Models; D012737:Sex Factors
D015703:Antigens, CD; C513384:CDH1 protein, human; D015820:Cadherins; C489332:ADH1B protein, human; D000426:Alcohol Dehydrogenase
ADH1B; CDH1; laryngeal cancer; polymorphism; prognosis
Gene. 2014 May 25;542(1):64-8
24582975
Am J Epidemiol. 2014 Jul 15;180(2):223-32
24875374
J Oral Pathol Med. 2015 Nov;44(10):769-75
25639971
Dev Biol. 1990 May;139(1):227-9
2328837
Mol Psychiatry. 2012 Apr;17(4):445-50
21968928
Hippokratia. 2013 Oct;17(4):313-8
25031508
Diagn Pathol. 2014 Jan 20;9:15
24443924
PLoS One. 2011;6(9):e25057
21966413
Mutat Res. 2005 Dec 11;591(1-2):110-22
16083916
Dev Dyn. 2010 Sep;239(9):2330-44
20652949
Eur Arch Otorhinolaryngol. 2015 Dec;272(12):3779-84
25510985
Am J Epidemiol. 2012 Jan 1;175(1):1-10
22156018
Med Sci Monit. 2013 Jul 17;19:584-91
23860397
Biol Psychiatry. 2011 Sep 15;70(6):504-12
21497796
J Mol Biol. 2000 Jun 9;299(3):551-72
10835267
Nat Genet. 2007 Mar;39(3):347-51
17293865
BMC Genet. 2014 Sep 30;15:102
25266489
Tumour Biol. 2015 Feb;36(2):1023-7
25323582
Mol Psychiatry. 2014 Jan;19(1):41-9
24166409
Curr Protoc Hum Genet. 2009 Jan;Chapter 2:Unit 2.12
19170031
J Natl Cancer Inst. 2007 May 16;99(10):777-89
17505073
Alcohol Res. 2012;34(3):339-44
23134050
Mol Carcinog. 2013 Nov;52 Suppl 1:E2-9
22674868
Nat Rev Gastroenterol Hepatol. 2013 Aug;10 (8):487-94
23712313
Tumour Biol. 2014 May;35(5):4659-65
24563277
Carcinogenesis. 2013 Oct;34(10):2286-91
23712746