[The clinical characteristics of 128 childhood- and adolescent-onset hypoparathyroidism in Peking Union Medical College Hospital: a retrospective analysis].
Objective:To study the clinical characteristics of childhood- and adolescent- onset hypoparathyroidism.Methods:The clinical data of 128 hypoparathyroidism patients with onset before the age of 18 years were collected and analyzed retrospectively.Results:The predominant features of the hypoparathyroidism were carpopedal spasm (89.3%, 108/121) and seizures (66.1%, 84/127). Intracranial calcification was identified in 89.4%(101/113) of the patients. Duration is an independent predictive factor (OR=1.483,P=0.011) for intracranial calcification. All the patients were treated with calcium and vitamin D or its metabolites. Hypercalciuria was associated with serum calcium (P=0.016).Conclusions:Carpopedal spasm and seizures were the main manifestations of childhood- and adolescent- onset hypoparathyroidism. Calcium and vitamin D or its metabolites are effective. Monitoring the concentration of serum and urinary calcium is of highly importance for the prevention of hypercalciuria.
Y P
YP
Li
T T
TT
Quan
O
O
Wang
Y
Y
Jiang
Y Y
YY
Hu
W B
WB
Xia
M
M
Li
X W
XW
Meng
Key Laboratory of Endocrinology of National Health And Family Planning Commission, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
X P
XP
Xing
D000293:Adolescent; D017668:Age of Onset; D002118:Calcium / Q000008:administration & dosage* / Q000097:blood / Q000652:urine; D002648:Child; D002675:Child, Preschool; D005260:Female; D006761:Hospitals; D006801:Humans; D006996:Hypocalcemia / Q000150:complications*; D007011:Hypoparathyroidism / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D012189:Retrospective Studies; D012640:Seizures / Q000175:diagnosis / Q000209:etiology*; D013035:Spasm / Q000209:etiology; D016896:Treatment Outcome; D014807:Vitamin D / Q000008:administration & dosage*
D014807:Vitamin D; D002118:Calcium