Hyperbaric oxygen therapy for late radiation-induced tissue toxicity: prospectively patient-reported outcome measures in breast cancer patients.
BACKGROUND
This study examines patient reported outcome measures of women undergoing hyperbaric oxygen treatment (HBOT) after breast-conserving therapy.


METHODS
Included were 57 women treated with HBOT for late radiation-induced tissue toxicity (LRITT) referred in the period January 2014-December 2015. HBOT consisted of (on average) 47 sessions. In total, 80 min of 100 % O2was administered under increased pressure of 2.4 ATA. Quality of life was assessed before and after treatment using the European Organization for Research and Treatment of Cancer (EORTC) QLQ-BR23, and a NRS pain score.


RESULTS
Fifty-seven women were available for evaluation before and after treatment. Before HBOT, patients had severe complaints of pain in the arm/shoulder (46 %), swollen arm/hand (14 %), difficulty to raise arm or move it sideways (45 %), pain in the area of the affected breast (67 %), swollen area of the affected breast (45 %), oversensitivity of the affected breast (54 %), and skin problems on/in the area of the affected breast (32 %); post HBOT, severe complaints were still experienced in 17, 7, 22, 15, 13, 15, and 11 % of the women, respectively. Differences were all significant. The NRS pain score improved at least 1 point (range 0-10) in 81 % of the patients (p < 0.05).


CONCLUSIONS
In these breast cancer patients treated with HBOT for LRITT, the patient-reported outcomes were positive and improvements were observed. HBOT was a well-tolerated treatment for LRITT and its side-effects were both minimal and reversible.
Hyperbaar Geneeskundig Centrum Rijswijk, Treubstraat 5a, 2288 EG, Rijswijk, The Netherlands. d.teguh@hgcrijswijk.nl.|Department of Surgery/Hyperbaric Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. d.teguh@hgcrijswijk.nl.
David N
http://orcid.org/0000-0002-1108-7389
DN
Teguh
Hyperbaar Geneeskundig Centrum Rijswijk, Treubstraat 5a, 2288 EG, Rijswijk, The Netherlands.
René
R
Bol Raap
Department of Radiation Oncology, Leiden University Medical Centre, Leiden, The Netherlands.|Radiotherapy Centre West, Medical Centre Haaglanden, The Hague, The Netherlands.
Henk
H
Struikmans
Department of Surgical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Cees
C
Verhoef
Department of Surgical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Linetta B
LB
Koppert
Hyperbaar Geneeskundig Centrum Rijswijk, Treubstraat 5a, 2288 EG, Rijswijk, The Netherlands.
Arne
A
Koole
University of Leuven, Leuven, The Netherlands.
Yadi
Y
Huang
Hyperbaar Geneeskundig Centrum Rijswijk, Treubstraat 5a, 2288 EG, Rijswijk, The Netherlands.|Department of Anesthesiology/Hyperbaric Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Rob A
RA
van Hulst
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000523:psychology / Q000532:radiotherapy*; D005060:Europe; D005260:Female; D005355:Fibrosis / Q000503:physiopathology; D006801:Humans; D006931:Hyperbaric Oxygenation / Q000379:methods*; D015412:Mastectomy, Segmental; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D010100:Oxygen / Q000627:therapeutic use; D000071066:Patient Reported Outcome Measures; D011788:Quality of Life; D011832:Radiation Injuries / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D011878:Radiotherapy / Q000009:adverse effects*; D057566:Self Report; D011795:Surveys and Questionnaires
D010100:Oxygen
Breast cancer; Fibrosis; Pain; Radiation toxicity; Radiotherapy
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