Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease.
In mammals, seven members of the sirtuin protein family known as class III histone deacetylase have been identified for their characteristic features. These distinguished characteristics include the tissues where they are distributed or located, enzymatic activities, molecular functions, and involvement in diseases. Among the sirtuin members, SIRT3 has received much attention for its role in cancer genetics, aging, neurodegenerative disease, and stress resistance. SIRT3 controls energy demand during stress conditions such as fasting and exercise as well as metabolism through the deacetylation and acetylation of mitochondrial enzymes. SIRT3 is well known for its ability to eliminate reactive oxygen species and to prevent the development of cancerous cells or apoptosis. This review article provides a comprehensive review on numerous (noteworthy) molecular functions of SIRT3 and its effect on cancer cells and various diseases including Huntington's disease, amyotrophic lateral sclerosis, and Alzheimer's disease.
Department of Genetic Engineering and Biotechnology, Jessore University of Science and Technology, Jessore, 7408, Bangladesh.
Aneesa
A
Ansari
Department of Genetic Engineering and Biotechnology, Jessore University of Science and Technology, Jessore, 7408, Bangladesh.
Md Shahedur
MS
Rahman
Department of Stem Cell and Regenerative Biology, Konkuk University, 120 Neungdong-Ro, Seoul, 05029, Korea.
Subbroto K
SK
Saha
Department of Genetic Engineering and Biotechnology, Jessore University of Science and Technology, Jessore, 7408, Bangladesh.
Forhad K
FK
Saikot
Central Scientific Instruments Organisation (CSIR-CSIO), Sector 30 C, Chandigarh, 160030, India.
Akash
A
Deep
Department of Civil & Environmental Engineering, Hanyang University, 222 Wangsimni-Ro, Seoul, 04763, Korea.
Ki-Hyun
KH
Kim
D000818:Animals; D002468:Cell Physiological Phenomena; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D056566:Sirtuin 3 / Q000378:metabolism*
D056566:Sirtuin 3
SIRT3; Silent Information Regulator 2; aging; cancer; sirtuin
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