Alarmin high mobility group box-1 in maternal serum as a potential biomarker of chorioamnionitis-associated preterm birth.
Chorioamnionitis is associated with an increased risk of spontaneous preterm birth. The aim of this study was to investigate the serum levels of high mobility group box-1 (HMGB1) in pregnancies with histological chorioamnionitis (HCA)-associated preterm labor (PTL) with intact membranes or preterm premature rupture of membranes (PPROM), and to access the role of serum HMGB1 in HCA and HCA-associated PTL. A total of 190 pregnant women were enrolled in this study: PLT patients with (n = 28) or without HCA (n = 36), PPROM patients with (n = 26) or without HCA (n = 65), and non-HCA PTL controls (n = 35). Maternal serum levels of HMGB1 were measured by enzyme-linked immunosorbent assay. Serum HMGB1 levels were significantly higher in PTL or PPROM patients than in control group (p < 0.01, respectively). The PPROM patients also exhibited higher serum HMGB1 levels compared to PTL patients (p = 0.015). HCA patients were characterized by significantly increased levels of serum HMGB1 when compared with non-HCA patients (p < 0.01). Therefore, maternal serum HMGB1 may become a potential biomarker of HCA and HCA-associated PTL.
a Department of Obstetrics and Gynecology , The Second Hospital of Tianjin Medical University , Tianjin , People's Republic of China and.|b Department of Obstetrics , Tianjin Central Hospital of Gynecology Obstetrics, Tianjin Medical University , Tianjin , People's Republic of China.
Xiao-Yuan
XY
Qiu
b Department of Obstetrics , Tianjin Central Hospital of Gynecology Obstetrics, Tianjin Medical University , Tianjin , People's Republic of China.
Lu
L
Sun
b Department of Obstetrics , Tianjin Central Hospital of Gynecology Obstetrics, Tianjin Medical University , Tianjin , People's Republic of China.
Xue-Ling
XL
Han
b Department of Obstetrics , Tianjin Central Hospital of Gynecology Obstetrics, Tianjin Medical University , Tianjin , People's Republic of China.
Ying
Y
Chang
b Department of Obstetrics , Tianjin Central Hospital of Gynecology Obstetrics, Tianjin Medical University , Tianjin , People's Republic of China.
Lan
L
Cheng
a Department of Obstetrics and Gynecology , The Second Hospital of Tianjin Medical University , Tianjin , People's Republic of China and.
Li-Rong
LR
Yin
D000328:Adult; D015415:Biomarkers / Q000097:blood; D002821:Chorioamnionitis / Q000097:blood*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000097:blood*; D024243:HMGB1 Protein / Q000097:blood*; D006801:Humans; D007752:Obstetric Labor, Premature / Q000097:blood*; D011247:Pregnancy
D015415:Biomarkers; D024243:HMGB1 Protein
Alarmin; HMGB1; chorioamnionitis; maternal serum; preterm birth