Serum FGF23 levels may not be associated with serum phosphate and 1,25-dihydroxyvitamin D levels in patients with Fanconi syndrome-induced hypophosphatemia.
Fibroblast growth factor 23 (FGF23) is regulated by sustained phosphate supplementation and restriction. However, few studies have investigated FGF23 levels in patients with Fanconi syndrome. Therefore, we evaluated intact and C-terminal FGF23 and FGF23-associated parameters in four patients with Fanconi syndrome. Serum intact and C-terminal FGF23 levels were extremely low. Although serum phosphate and 1,25-dihydroxyvitamin D levels improved to or above the normal range within 1 year of treatment with oral phosphate and calcitriol, serum FGF23 levels remained low. Serum FGF23 levels in patients with Fanconi syndrome might be regulated by novel factors other than serum phosphate and 1,25-dihydroxyvitamin D levels.
Division of Nephrology and Kidney Center , Kobe University Graduate School of Medicine , 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017 , Japan.
Shunsuke
S
Goto
Division of Nephrology and Kidney Center , Kobe University Graduate School of Medicine , 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017 , Japan.
Hideki
H
Fujii
Division of Nephrology and Kidney Center , Kobe University Graduate School of Medicine , 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017 , Japan.
Keiji
K
Kono
Division of Nephrology and Kidney Center , Kobe University Graduate School of Medicine , 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017 , Japan.
Kentaro
K
Watanabe
Division of Nephrology and Kidney Center , Kobe University Graduate School of Medicine , 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017 , Japan.
Kentaro
K
Nakai
Division of Nephrology and Kidney Center , Kobe University Graduate School of Medicine , 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017 , Japan.
Shinichi
S
Nishi
CKD; FGF-23; vitamin D
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