Measurement of Vibration Detection Threshold and Tactile Spatial Acuity in Human Subjects.
Tests that allow the precise determination of psychophysical thresholds for vibration and grating orientation provide valuable information about mechanosensory function that are relevant for clinical diagnosis as well as for basic research. Here, we describe two psychophysical tests designed to determine the vibration detection threshold (automated system) and tactile spatial acuity (handheld device). Both procedures implement a two-interval forced-choice and a transformed-rule up and down experimental paradigm. These tests have been used to obtain mechanosensory profiles for individuals from distinct human cohorts such as twins or people with sensorineural deafness.
Department of Anesthesiology and Intensive Care Medicine, Charite Universitätsmedzin, Campus Virchow Klinikum und Campus Charite Mitte; Department of Neuroscience, Molecular Physiology of Somatic Sensation, Max Delbrück Center for Molecular Medicine; rabih.moshourab@mdc-berlin.de.
Rabih
R
Moshourab
Department of Neuroscience, Molecular Physiology of Somatic Sensation, Max Delbrück Center for Molecular Medicine.
Henning
H
Frenzel
Institute of Pharmacology, University of Heidelberg.
Stefan
S
Lechner
Department of Neuroscience, Molecular Physiology of Somatic Sensation, Max Delbrück Center for Molecular Medicine.
Julia
J
Haseleu
Department of Neuroscience, Molecular Physiology of Somatic Sensation, Max Delbrück Center for Molecular Medicine.
Valérie
V
Bégay
Department of Neuroscience, Molecular Physiology of Somatic Sensation, Max Delbrück Center for Molecular Medicine.
Damir
D
Omerbašić
Department of Neuroscience, Molecular Physiology of Somatic Sensation, Max Delbrück Center for Molecular Medicine.
Gary R
GR
Lewin
D005385:Fingers / Q000502:physiology; D006801:Humans; D009949:Orientation / Q000502:physiology*; D010812:Physical Stimulation / Q000295:instrumentation* / Q000379:methods*; D012684:Sensory Thresholds / Q000502:physiology*; D014110:Touch / Q000502:physiology*; D014732:Vibration
J Physiol. 1979 Dec;297(0):405-22
536918
Front Hum Neurosci. 2013 Sep 13;7:579
24062677
Int Arch Occup Environ Health. 2002 Jan;75(1-2):78-84
11898880
Somatosens Mot Res. 2002;19(2):114-24
12088385
J Hand Ther. 2011 Jul-Sep;24(3):240-55; quiz 256
21439781
J Neurosci Methods. 2005 Sep 30;147(2):75-81
15970331
Nat Commun. 2014 Mar 24;5:3520
24662763
Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4811-4
11287663
Nature. 2007 Jan 11;445(7124):206-9
17167420
Int Arch Occup Environ Health. 2003 Sep;76(7):517-28
12827371
Somatosens Mot Res. 2008 Mar;25(1):49-59
18344147
Nature. 2012 Feb 19;483(7388):176-81
22343900
Exp Brain Res. 1999 Nov;129(2):211-7
10591895
J Acoust Soc Am. 1988 Nov;84(5):1680-94
3209773
PLoS Biol. 2012;10(5):e1001318
22563300
Neurology. 1994 Dec;44(12):2361-6
7991127
Nat Neurosci. 2015 Jan;18(1):10-6
25469543
Nature. 2014 Dec 4;516(7529):121-5
25471886
Pflugers Arch. 2015 Jan;467(1):121-32
24981693
J Vis Exp. 2009 Jun 03;(28):null
19578327
J Neurophysiol. 2007 Dec;98(6):3802-8
17942620
Brain Res. 2013 Sep 5;1529:46-55
23845924
Physiology (Bethesda). 2013 May;28(3):142-50
23636260
J Exp Child Psychol. 2007 Oct;98(2):113-30
17597140
PLoS One. 2014 Jan 08;9(1):e84949
24416318
Somatosens Mot Res. 2005 Mar-Jun;22(1-2):49-56
16191758
Nature. 2014 May 29;509(7502):622-6
24717433
J Neurosci Methods. 2012 Mar 15;204(2):215-20
22155443
J Acoust Soc Am. 1996 May;99(5):3149-53
8642123
Science. 1967 Feb 3;155(3762):597-600
4959494
J Acoust Soc Am. 1971 Feb;49(2):Suppl 2:467+
5541744
Nat Neurosci. 2011 Nov 20;15(1):138-45
22101641
Am J Hum Genet. 2014 May 1;94(5):734-44
24726473
J Neurosci. 2003 Apr 15;23(8):3439-45
12716952
PLoS One. 2013 Dec 19;8(12):e84650
24454612