Potential allelopathic azaphilones produced by the endophytic Chaetomium globosum TY1 inhabited in Ginkgo biloba using the one strain-many compounds method.
On the basis of the one strain-many compounds strategy, seven azaphilones, including Chaetomugilin A (1), D (2), S (3), I (4), J (5), Q (6) and O (7), were isolated from the endophytic Chaetomium globosum TY1. Their structures were identified by NMR and HRESIMS spectrometry data. All azaphilones were evaluated for plant growth regulation using eight species of herbaceous plant seeds seedling growth bioassay, which showed the plant growth influence of the seedling. Among these compounds tested, Chaetomugilin O (7) with tetrahydrofuran exhibited higher response index and lower IC50values than positive control glyphosate, a broad-spectrum systemic herbicide. 1-3 also showed better or similar inhibit activity to glyphosate. The structure-allelopathic activity relationship analysis of these isolated azaphilones indicates that both tetrahydrofuran and tetrahydrofuran combine with lactones ring groups give potent inhibition of seedling growth. Chaetomugilin O and Chaetomugilin A, D, S could be used to develop natural eco-friendly herbicides.
a College of Plant Science , Jilin University , Changchun , China.
Dacheng
D
Wang
a College of Plant Science , Jilin University , Changchun , China.
Yamei
Y
Zhang
c Department of Biochemistry & Biomedical Sciences , McMaster University , Hamilton , Canada.
Xiang
X
Li
a College of Plant Science , Jilin University , Changchun , China.
Hongyu
H
Pan
a College of Plant Science , Jilin University , Changchun , China.
Mengyuan
M
Chang
a College of Plant Science , Jilin University , Changchun , China.
Tianyu
T
Zheng
a College of Plant Science , Jilin University , Changchun , China.
Jinzhu
J
Sun
a College of Plant Science , Jilin University , Changchun , China.
Daren
D
Qiu
a College of Plant Science , Jilin University , Changchun , China.
Mingzhe
M
Zhang
b Department of Biology, Centre for Wood Science , University of Hamburg , Hamburg Germany.
Dongsheng
D
Wei
a College of Plant Science , Jilin University , Changchun , China.
Jianchun
J
Qin
D001372:Aza Compounds / Q000737:chemistry* / Q000494:pharmacology*; D001578:Benzopyrans; D002597:Chaetomium / Q000737:chemistry*; D060026:Endophytes / Q000737:chemistry; D020441:Ginkgo biloba / Q000382:microbiology*; D005998:Glycine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D006540:Herbicides / Q000737:chemistry / Q000633:toxicity*; D009682:Magnetic Resonance Spectroscopy; D010860:Pigments, Biological; D012639:Seeds / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013329:Structure-Activity Relationship; D000097797:Glyphosate
D001372:Aza Compounds; D001578:Benzopyrans; D005998:Glycine; D006540:Herbicides; D010860:Pigments, Biological; D000097797:Glyphosate; C494154:azaphilone
Herbicides; allelochemicals; azaphilone; phytotoxicity