Hemoptysis in a Patient with Elevated Immunoglobulin E.
Recurrent pneumonia with cavitation leading to pneumatoceles, secondary fungal infections, and hemoptysis are major causes of mortality and morbidity in patients with hyper-IgE syndrome. Prevention and aggressive treatment of pneumonia in these patients are essential to prevent further lung damage, but treatment may be delayed because the classic signs/symptoms of infection such as fever, chills, or rigors may be lacking. Early imaging to identify infection is essential for diagnosis and treatment. The mainstay of therapy is continuous, full-dose daily trimethoprim-sulfamethoxazole and commonly fungal coverage. Because hyper-IgE syndrome is a progressive disease, patients' condition may worsen despite compliance with prophylactic therapy.
Division of Allergy and Clinical Immunology, Icahn School of Medicine, Mount Sinai, New York, NY.
Yael
Y
Gernez
Division of Allergy and Clinical Immunology, Icahn School of Medicine, Mount Sinai, New York, NY.
Angela
A
Tsuang
Division of Allergy and Clinical Immunology, Icahn School of Medicine, Mount Sinai, New York, NY.
Tukisa D
TD
Smith
Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine, Mount Sinai, New York, NY.
Khurram
K
Shahjehan
Division of Allergy and Clinical Immunology, Icahn School of Medicine, Mount Sinai, New York, NY.
Yiqun
Y
Hui
Division of Allergy and Clinical Immunology, Icahn School of Medicine, Mount Sinai, New York, NY.
Paul J
PJ
Maglione
Division of Allergy and Clinical Immunology, Icahn School of Medicine, Mount Sinai, New York, NY. Electronic address: charlotte.cunningham-rundles@mssm.edu.
Charlotte
C
Cunningham-Rundles
D000328:Adult; D006469:Hemoptysis / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000628:therapy; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D008168:Lung / Q000000981:diagnostic imaging; D008297:Male; D011859:Radiography; D055815:Young Adult
D007073:Immunoglobulin E
Aspergilloma; Eczema; Immunodeficiency; STAT3; hyper-IgE syndrome
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