Colorectal Cancer and Dysplasia in Inflammatory Bowel Disease: A Review of Disease Epidemiology, Pathophysiology, and Management.
Crohn disease and ulcerative colitis are chronic inflammatory bowel diseases (IBD) characterized by recurrent episodes of mucosal inflammation. This chronic mucosal inflammation has several potential consequences, one of which is the occurrence of colitis-associated colorectal cancer. Over the past decade, our understanding of the epidemiology, pathophysiology, and overall approach to diagnosing and managing colitis-associated colorectal cancer has grown considerably. In the current review article, we outline these advancements and highlight areas in need of further research. Cancer Prev Res; 9(12); 887-94. ©2016 AACR.
Division of Gastroenterology, University of California San Diego, La Jolla, California.
Parambir S
PS
Dulai
Division of Gastroenterology, University of California San Diego, La Jolla, California.
William J
WJ
Sandborn
Division of Gastroenterology, University of California San Diego, La Jolla, California. s1gupta@ucsd.edu.|Veterans Affairs San Diego Healthcare System, San Diego, California.|Moores Cancer Center, University of California San Diego, La Jolla, California.
Samir
S
Gupta
D063646:Carcinogenesis / Q000473:pathology; D018890:Chemoprevention; D003093:Colitis, Ulcerative / Q000453:epidemiology* / Q000473:pathology; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000517:prevention & control; D003424:Crohn Disease / Q000453:epidemiology* / Q000473:pathology; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D012307:Risk Factors; D013997:Time Factors
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