Cardiotoxicity of nano-particles.
Nano-particles (NPs) are used in industrial and biomedical fields such as cosmetics, food additives and biosensors. Beside their favorable properties, nanoparticles are responsible for toxic effects. Local adverse effects and/or systemic toxicity are described with nanoparticle delivery to target organs of the human body. Animal studies provide evidence for the aforementioned toxicity. Cardiac function is a specific target of nanoparticles. Thus, reviewing the current bibliography on cardiotoxicity of nanoparticles and specifically of titanium, zinc, silver, carbon, silica and iron oxide nano-materials is the aim of this study.
Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Hasan Badie
HB
Bostan
Department of Physiology and Pharmacology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran; Scientific Educational Center of Nanotechnology, Far Eastern Federal University, 10 Pushkinskaya Street, Vladivostok 690950, Russia.
Ramin
R
Rezaee
Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Mahmoud Gorji
MG
Valokala
Cardiology Clinic, General University Hospital of Larisa, Larisa, Greece.
Konstantinos
K
Tsarouhas
Scientific Educational Center of Nanotechnology, Far Eastern Federal University, 10 Pushkinskaya Street, Vladivostok 690950, Russia.
Kirill
K
Golokhvast
Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, Heraklion 71003, Greece. Electronic address: aris@med.uoc.gr.
Aristidis M
AM
Tsatsakis
Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: karimiG@mums.ac.ir.
Gholamreza
G
Karimi
D006321:Heart / Q000187:drug effects*; D006801:Humans; D053758:Nanoparticles / Q000633:toxicity*
Cardiac toxicity; Inflammatory marker; Nano-particle; Reactive oxygen species