Quantitative177Lu SPECT imaging using advanced correction algorithms in non-reference geometry.
Peptide receptor therapy with177Lu-labelled somatostatin analogues is a promising tool in the management of patients with inoperable or metastasized neuroendocrine tumours. The aim of this work was to perform accurate activity quantification of177Lu in complex anthropomorphic geometry using advanced correction algorithms. Acquisitions were performed on the higher177Lu photopeak (208keV) using a Philips IRIX gamma camera provided with medium-energy collimators. System calibration was performed using a 16mL Jaszczak sphere surrounded by non-radioactive water. Attenuation correction was performed using μ-maps derived from CT data, while scatter and septal penetration corrections were performed using the transmission-dependent convolution-subtraction method. SPECT acquisitions were finally corrected for dead time and partial volume effects. Image analysis was performed using the commercial QSPECT software. The quantitative SPECT approach was validated on an anthropomorphic phantom provided with a home-made insert simulating a hepatic lesion. Quantitative accuracy was studied using three tumour-to-background activity concentration ratios (6:1, 9:1, 14:1). For all acquisitions, the recovered total activity was within 12% of the calibrated activity both in the background region and in the tumour. Using a 6:1 tumour-to-background ratio the recovered total activity was within 2% in the tumour and within 5% in the background. Partial volume effects, if not properly accounted for, can lead to significant activity underestimations in clinical conditions. In conclusion, accurate activity quantification of177Lu can be obtained if activity measurements are performed with equipment traceable to primary standards, advanced correction algorithms are used and acquisitions are performed at the 208keV photopeak using medium-energy collimators.
ENEA, National Institute of Ionizing Radiation Metrology, Via Anguillarese 301, 00123 Rome, Italy; Department of Human Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University of Rome, Via Borelli 50, 00161 Rome, Italy. Electronic address: marco.darienzo@enea.it.
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D'Arienzo
ENEA, National Institute of Ionizing Radiation Metrology, Via Anguillarese 301, 00123 Rome, Italy.
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Cozzella
ENEA, National Institute of Ionizing Radiation Metrology, Via Anguillarese 301, 00123 Rome, Italy.
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Fazio
ENEA, National Institute of Ionizing Radiation Metrology, Via Anguillarese 301, 00123 Rome, Italy.
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De Felice
Laboratory of Medical Physics and Expert Systems, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00044 Rome, Italy.
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Iaccarino
Laboratory of Medical Physics and Expert Systems, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00044 Rome, Italy.
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D'Andrea
Laboratory of Medical Physics and Expert Systems, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00044 Rome, Italy; Medical Physics Section, Department of Biopathology and Imaging, Tor Vergata University, Via Montpellier 1, 00133 Rome, Italy.
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Ungania
Laboratory of Medical Physics and Expert Systems, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00044 Rome, Italy.
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Cazzato
ABX-CRO Advanced Pharmaceutical Services, Forschungsgesellschaft m.b.H. Blasewitzer Straße 78-80 D, 01307 Dresden, Germany.
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Schmidt
ABX-CRO Advanced Pharmaceutical Services, Forschungsgesellschaft m.b.H. Blasewitzer Straße 78-80 D, 01307 Dresden, Germany.
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Kimiaei
Laboratory of Medical Physics and Expert Systems, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00044 Rome, Italy.
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Strigari
D000465:Algorithms; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008187:Lutetium; D019047:Phantoms, Imaging; D011868:Radioisotopes; D059629:Signal-To-Noise Ratio; D013382:Subtraction Technique; D015899:Tomography, Emission-Computed, Single-Photon
D011868:Radioisotopes; D008187:Lutetium
Correction algorithms; PRRT with (177)Lu-labelled somatostatin analogue; Quantitative imaging; Transmission-dependent convolution-subtraction correction algorithm