Potential Markers in Cardiac Hypertrophy?
Cardiomyopathies are diagnosed based on medical history of patient (symptoms and family history), physical examination, results of echocardiogram and in some situations additionally ECG or chest-X-ray results. Currently used non-invasive diagnostic methods, could be complemented by biochemical tests. In this review some emerging potential biomarkers such as: osteopontin, ST-2 receptor, osteoprotegerin, neopterin, urocortins, growth differentiation factor 15 and urotensin II are described. In current article human and non human investigations have been reviewed, since rat is most commonly used model in experimental cardiology and gives important foundations to clinical knowledge.
Department of Laboratory Medicine, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland; Department of Pharmacology and Therapeutics, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
Bartosz
B
Malinowski
Department of Laboratory Medicine, Collegium Medicum, Nicolaus Copernicus University , Bydgoszcz, Poland.
Gabriele
G
Fulgheri
Department of Pharmacology and Therapeutics, Collegium Medicum, Nicolaus Copernicus University , Bydgoszcz, Poland.
Michal
M
Wicinski
Department of Pharmacology and Therapeutics, Collegium Medicum, Nicolaus Copernicus University , Bydgoszcz, Poland.
Elzbieta
E
Grzesk
Department of Laboratory Medicine, Collegium Medicum, Nicolaus Copernicus University , Bydgoszcz, Poland.
Grazyna
G
Odrowaz-Sypniewska
Department of Pharmacology and Therapeutics, Collegium Medicum, Nicolaus Copernicus University , Bydgoszcz, Poland.
Grzegorz
G
Grześk
Department of Pharmacology and Therapeutics, Collegium Medicum, Nicolaus Copernicus University , Bydgoszcz, Poland.
Nasser
N
Darwish
Cardiomyopathy; ST-2 receptor; biomarkers of cardiac remodeling; growth differentiation factor 15; heart failure; neopterin; osteopontin; osteoprotegerin; urocortins; urotensin II
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