Selective Palladium-Catalyzed Aminocarbonylation of Olefins to Branched Amides.
A general and efficient protocol for iso-selective aminocarbonylation of olefins with aliphatic amines has been developed for the first time. Key to the success for this process is the use of a specific 2-phosphino-substituted pyrrole ligand in the presence of PdX2(X=halide) as a pre-catalyst. Bulk industrial and functionalized olefins react with various aliphatic amines, including amino-acid derivatives, to give the corresponding branched amides generally in good yields (up to 99 %) and regioselectivities (b/l up to 99:1).
Leibniz-Institut für Katalyse an der, Universität Rostock, Albert-Einstein-Straße 29a, 18059, Rostock, Germany.
Jie
J
Liu
Leibniz-Institut für Katalyse an der, Universität Rostock, Albert-Einstein-Straße 29a, 18059, Rostock, Germany.
Haoquan
H
Li
Leibniz-Institut für Katalyse an der, Universität Rostock, Albert-Einstein-Straße 29a, 18059, Rostock, Germany.
Anke
A
Spannenberg
Evonik Industries AG, Paul-Baumann-Straße 1, 45772, Marl, Germany.|Lehrstuhl für Theoretische Chemie, 44780, Bochum, Germany.
Robert
R
Franke
Leibniz-Institut für Katalyse an der, Universität Rostock, Albert-Einstein-Straße 29a, 18059, Rostock, Germany.
Ralf
R
Jackstell
Leibniz-Institut für Katalyse an der, Universität Rostock, Albert-Einstein-Straße 29a, 18059, Rostock, Germany. matthias.beller@catalysis.de.
Matthias
0000-0001-5709-0965
M
Beller
P ligands; amines; carbonylation; olefins; synthetic methodology