Steroid-Loaded Hemostatic Nanoparticles Combat Lung Injury after Blast Trauma.
In response to the lack of therapeutics for internal bleeding following a traumatic event, we synthesized hemostatic dexamethasone nanoparticles (hDNP) to help alleviate internal hemorrhaging. hDNP consist of a block copolymer, poly(lactic-co-glycolic acid)-poly(l-lysine)-poly(ethylene glycol) conjugated to a peptide, glycine-arginine-glycine-aspartic acid-serine (GRGDS). These particles were evaluated as treatment for primary blast lung injury in a rodent model. Animals were randomly placed into test and control groups, exposed to blast and given immediate injection. Recovery was assessed using physiological parameters and immunohistochemistry. We found that dexamethasone-loaded hemostatic nanoparticles alleviate physiological deprivation caused by blast injury and reduce lung injury damage.
School of Biomedical Engineering and Sciences, Virginia Tech University, Blacksburg, VA.
William B
WB
Hubbard
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH.
Margaret M
MM
Lashof-Sullivan
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH.
Erin B
EB
Lavik
School of Biomedical Engineering and Sciences, Virginia Tech University, Blacksburg, VA; Research Services, Salem VAMC, Salem, VA.
Pamela J
PJ
VandeVord
dexamethasone; hemostatic; nanoparticles; synthetic platelets; trauma
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