Autoimmune gastritis.
Autoimmune gastritis is a chronic inflammatory disease with destruction of parietal cells of the corpus and fundus of the stomach. The known consequence is vitamin B12 deficiency and, consequently, pernicious anemia. However, loss of parietal cells reduces secretion of gastric acid which is also required for absorption of inorganic iron; thus, iron deficiency is commonly found in patients with autoimmune gastritis. This usually precedes vitamin B12 deficiency and is found mainly in young women. Patients with chronic iron deficiency, especially those refractory to oral iron therapy, should therefore be evaluated for the presence of autoimmune gastritis.
Department of Medicine III, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, 1090, Austria. stefanie.dabsch@meduniwien.ac.at.
Stefanie
http://orcid.org/0000-0002-5212-0552
S
Kulnigg-Dabsch
D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology*; D002908:Chronic Disease; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005756:Gastritis / Q000276:immunology*; D005757:Gastritis, Atrophic / Q000276:immunology; D006801:Humans; D008297:Male; D010295:Parietal Cells, Gastric / Q000276:immunology*; D014806:Vitamin B 12 Deficiency / Q000276:immunology
Autoimmune gastritis; Chronic atrophic gastritis; Gastric cancer; Iron deficiency; Vitamin B 12 deficiency
N Engl J Med. 1968 Sep 26;279(13):672-4
5670905
Am J Med. 2001 Oct 15;111(6):439-45
11690568
Gut. 1997 Apr;40(4):435-9
9176066
Am J Med. 1967 Oct;43(4):555-69
6061265
Dig Dis Sci. 2012 Oct;57(10):2504-15
22543844
Am J Gastroenterol. 2008 Nov;103(11):2883-9
18775015
Gastroenterol Res Pract. 2012;2012:287825
23316222
Aliment Pharmacol Ther. 2011 Apr;33(7):768-81
21261669
Hepatogastroenterology. 2006 Jan-Feb;53(67):11-4
16506368
Gastrointest Endosc. 2013 Feb;77(2):284-92
23199649
Blood. 2006 Feb 15;107(4):1673-9
16239424
Curr Gastroenterol Rep. 2011 Dec;13(6):518-24
21947876
Autoimmunity. 1992;12(1):1-7
1319758
Cell. 2005 Sep 9;122(5):789-801
16143108
Clin Rev Allergy Immunol. 2012 Jun;42(3):269-78
21174235
Cancer Epidemiol Biomarkers Prev. 2013 May;22(5):821-6
23456556
Haematologica. 2005 May;90(5):585-95
15921373
Scand J Gastroenterol. 2014 Nov;49(11):1394-6
25211191
Autoimmun Rev. 2010 Dec;10(2):80-3
20696284
J Lab Clin Med. 1978 Jul;92(1):108-16
26726
Diabet Med. 2000 Oct;17(10):749-51
11110510
Gut. 2005 Sep;54(9):1232-6
16099791
Nat Rev Gastroenterol Hepatol. 2013 Sep;10(9):529-41
23774773
Aliment Pharmacol Ther. 2011 Jun;33(12):1361-9
21492197
Am J Gastroenterol. 1998 Nov;93(11):2113-8
9820382
Digestion. 1988;39(2):61-79
3044896
Cancer Res. 1988 Jul 1;48(13):3554-60
3288329
Gastrointest Endosc. 2007 Aug;66(2):394-5; discussion 395
17643720
Gastroenterology. 1998 Aug;115(2):340-7
9679039
J Clin Invest. 1964 Jun;43:1185-91
14171795
Br J Haematol. 1972 Sep;23:Suppl:101-7
4567184
Clin Gastroenterol Hepatol. 2006 Mar;4(3):306-14
16527693
Immunol Lett. 2012 Sep;147(1-2):63-6
22771341
Gastrointest Endosc. 2006 Apr;63(4):570-80
16564854
Gut. 2000 Jun;46 Suppl 3-4:IV1-IV5
10862605
Gut. 2011 Oct;60(10):1309-16
21561874
Clin Dev Immunol. 2012;2012:520970
23251219
Autoimmun Rev. 2014 Apr-May;13(4-5):459-62
24424193
Scand J Gastroenterol. 1984 Nov;19(8):1075-80
6398507
Am J Surg Pathol. 1995;19 Suppl 1:S8-19
7762739
Arthritis Rheum. 2007 Jun;56(6):1736-44
17530702
Clin Chem Lab Med. 2008;46(5):577-87
18839462
Ann Intern Med. 2003 Sep 2;139(5 Pt 1):346-51
12965943
Autoimmunity. 2012 Nov;45(7):527-32
22779747
Am J Surg Pathol. 2015 Dec;39(12):1611-20
26291507
Arch Intern Med. 1999 Aug 9-23;159(15):1726-30
10448775
Immunol Today. 2000 Jul;21(7):348-54
10871877
Scand J Gastroenterol Suppl. 1999;230:9-16
10499456
Clin Chem Lab Med. 2010 Sep;48(9):1327-32
20604730
J Clin Endocrinol Metab. 2008 Feb;93(2):363-71
18029461
Eur J Gastroenterol Hepatol. 2014 Sep;26(9):941-8
25014624
Blood Cells Mol Dis. 2007 Sep-Oct;39(2):178-83
17493846
Am J Gastroenterol. 2009 Aug;104(8):2071-9
19491828
Scand J Gastroenterol. 1997 May;32(5):469-72
9175209
Aliment Pharmacol Ther. 2013 Feb;37(4):375-82
23216458
Z Gastroenterol. 1992 Oct;30(10):729-35
1441676
Endoscopy. 2012 Jan;44(1):74-94
22198778