Room Temperature Catalyst System for the Hydroarylation of Olefins.
A simple protocol for the hydroarylation of olefins to yield diarylmethine products is described. A Friedel-Crafts-type synthetic strategy allows direct access to biorelevant products in high atom efficiency. A combination of substoichiometric amounts of TMSCl and ZnBr2promotes a rapid hydroarylation process at ambient temperature. The method is high yielding and is amenable to scale-up protocols.
Department of Chemistry and Biochemistry, Loyola University Chicago , 1068 West Sheridan Rd, Chicago, Illinois 60660, United States.
Siu Yin
SY
Lee
Department of Chemistry and Biochemistry, Loyola University Chicago , 1068 West Sheridan Rd, Chicago, Illinois 60660, United States.
Alexander
A
Villani-Gale
Department of Chemistry and Biochemistry, Loyola University Chicago , 1068 West Sheridan Rd, Chicago, Illinois 60660, United States.
Chad C
CC
Eichman