Prognostic nomogram for previously untreated adult patients with acute myeloid leukemia.
This study was designed to perform an acceptable prognostic nomogram for acute myeloid leukemia. The clinical data from 311 patients from our institution and 165 patients generated with Cancer Genome Atlas Research Network were reviewed. A prognostic nomogram was designed according to the Cox's proportional hazard model to predict overall survival (OS). To compare the capacity of the nomogram with that of the current prognostic system, the concordance index (C-index) was used to validate the accuracy as well as the calibration curve. The nomogram included 6 valuable variables: age, risk stratifications based on cytogenetic abnormalities, status of FLT3-ITD mutation, status of NPM1 mutation, expression of CD34, and expression of HLA-DR. The C-indexes were 0.71 and 0.68 in the primary and validation cohort respectively, which were superior to the predictive capacity of the current prognostic systems in both cohorts. The nomogram allowed both patients with acute myeloid leukemia and physicians to make prediction of OS individually prior to treatment.
Department of Hematology, The Third Affiliated Hospital of Soochow University, China.|Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, China.|Cancer Immunotherapy Engineering Research Center of Jiangsu Province, China.|Institute of Cell Therapy, Soochow University, China.
Zhuojun
Z
Zheng
Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, China.|Cancer Immunotherapy Engineering Research Center of Jiangsu Province, China.|Institute of Cell Therapy, Soochow University, China.|Department of Oncology, The Third Affiliated Hospital of Soochow University, China.
Xiaodong
X
Li
Department of Hematology, The Third Affiliated Hospital of Soochow University, China.
Yuandong
Y
Zhu
Department of Hematology, The Third Affiliated Hospital of Soochow University, China.
Weiying
W
Gu
Department of Hematology, The Third Affiliated Hospital of Soochow University, China.
Xiaobao
X
Xie
Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, China.|Cancer Immunotherapy Engineering Research Center of Jiangsu Province, China.|Institute of Cell Therapy, Soochow University, China.
Jingting
J
Jiang
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D049451:Nomograms; D009687:Nuclear Proteins / Q000235:genetics; D000090243:Nucleophosmin; D011379:Prognosis; D016016:Proportional Hazards Models; D055815:Young Adult; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics
D006684:HLA-DR Antigens; C000716967:NPM1 protein, human; D009687:Nuclear Proteins; D000090243:Nucleophosmin; C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3
TCGA; acute myeloid leukemia; nomogram; prediction; prognosis
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