Up-date on the NeoVitaA Trial: Obstacles, challenges, perspectives, and local experiences.
The aim of the NeoVitaA Trial is to assess the role of postnatal additional high-dose oral vitamin A supplementation for 28 days in reducing Bronchopulmonary dysplasia (BPD) or death in extremely low birth weight (ELBW) infants at 36 weeks postmenstrual age (PMA). All infants (both intervention and control group) will be provided with basic vitamin A (1000 IU/kg/day) in addition to trial intervention.In this short communication, we will give an up-date on obstacles, challenges as well as perspectives and potential solutions when putting into place a multicenter, double-blind, randomized trial in this cohort of extremely susceptible infants.
Neonatal Unit, University Hospital of Saarland, Building 9, 66421, Homburg, Germany. sascha.meyer@uks.eu.
Sascha
S
Meyer
Neonatal Unit, University Hospital of Saarland, Building 9, 66421, Homburg, Germany.
Ludwig
L
Gortner
D001997:Bronchopulmonary Dysplasia / Q000401:mortality / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004750:Enteral Nutrition; D005858:Germany; D005865:Gestational Age; D006801:Humans; D052577:Infant, Extremely Low Birth Weight; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D014801:Vitamin A / Q000008:administration & dosage*
D014801:Vitamin A
Bronchopulmonary dysplasia; Extremely low birth weight infants; Vitamin A
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