Pregnancy as a possible trigger for heritable pulmonary arterial hypertension.
It is unclear whether pregnancy is a trigger or accelerant for idiopathic pulmonary arterial hypertension (PAH). Alternatively, its frequency close to the onset of symptoms and diagnosis in the idiopathic PAH population may represent a coincidence in a disease that predominates in young women. We describe a carrier of a BMPR2 gene mutation who had an uneventful first pregnancy but had aggressive PAH during her second pregnancy and now has ongoing heritable PAH. The possible role of pregnancy as a trigger in this vulnerable patient is discussed. Databases of patients with heritable PAH should be explored to see whether pregnancy is related to overt manifestation of the disease.
Center for Pulmonary Vascular Disease, Jewish General Hospital and McGill University, Montreal, Quebec, Canada.
Maude
M
Limoges
Center for Pulmonary Vascular Disease, Jewish General Hospital and McGill University, Montreal, Quebec, Canada.
David
D
Langleben
Pulmonary Division, Rabin Medical Center and Tel Aviv University, Tel Aviv, Israel.
Benjamin D
BD
Fox
Department of Obstetrics, Jewish General Hospital and McGill University, Montreal, Quebec, Canada.
Roberta
R
Shear
Department of Anesthesiology, Jewish General Hospital and McGill University, Montreal, Quebec, Canada.
Paul
P
Wieczorek
Center for Pulmonary Vascular Disease, Jewish General Hospital and McGill University, Montreal, Quebec, Canada.
Lawrence G
LG
Rudski
Center for Pulmonary Vascular Disease, Jewish General Hospital and McGill University, Montreal, Quebec, Canada.
Andrew M
AM
Hirsch
Center for Pulmonary Vascular Disease, Jewish General Hospital and McGill University, Montreal, Quebec, Canada.
Robert D
RD
Schlesinger
Center for Pulmonary Vascular Disease, Jewish General Hospital and McGill University, Montreal, Quebec, Canada.
Lyda
L
Lesenko
BMPR2; pregnancy; pulmonary arterial hypertension; right ventricle
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