The effect of hyperoxia on central blood pressure in healthy subjects.
BACKGROUND
Hyperoxia increases total peripheral resistance by acting locally but also inhibits the activity of carotid body chemoreceptors. We studied the effect of hyperoxia on central pressure in normotensive subjects.


METHODS
Medical air followed by 100% oxygen was provided to 19 subjects (12/7 female/male, age 28.2 ±1.1 years) for 15 min through a non-rebreather mask. Central blood pressure was then measured using applanation tonometry.


RESULTS
After the first 2 min of hyperoxia, heart rate decreased significantly (65 ±2.6 beats/min vs. 61 ±2.1 beats/min,p= 0.0002). Peripheral and central blood pressure remained unchanged, while hemoglobin oxygen saturation and subendocardial viability ratio index increased (97 ±0.4% vs. 99 ±0.2%,p= 0.03; 168 ±8.4% vs. 180 ±8.2%,p= 0.009). After 15 min of 100% oxygen ventilation, heart rate and peripheral and central blood pressures remained unchanged from the first 2 min. The augmentation index, augmentation pressure and ejection duration increased as compared to baseline values and those obtained at 2 min (-5.1 ±2.9% vs. -1.2 ±2.6%,p= 0.005 and -4.6 ±2.7% vs. -1.2 ±2.6%,p= 0.0015; -1.3 ±0.7 mm Hg vs. -0.2 ±1.2 mm Hg,p= 0.003 and -1.1 ±0.7 mm Hg vs. -0.2 ±1.2 mm Hg,p= 0.012; 323 ±3.6 ms vs. 330 ±3.5 ms,p= 0.0002 and 326 ±3.5 ms vs. 330 ±3.5 ms,p= 0.021, respectively).


CONCLUSIONS
The present study shows that hyperoxia does not affect central blood pressure in young healthy subjects and may improve myocardial blood supply estimated indirectly from applanation tonometry.
Department of Internal Medicine, Hypertension and Vascular Diseases, Medical University of Warsaw, Warsaw, Poland.
Maciej
M
Siński
Department of Internal Medicine, Hypertension and Vascular Diseases, Medical University of Warsaw, Warsaw, Poland.
Jacek
J
Lewandowski
Department of Pulmonary Circulation and Thromboembolic Diseases, Center of Postgraduate Medical Education, Otwock, Poland.
Anna
A
Dobosiewicz
Department of Biophysics and Physiology, Medical University of Warsaw, Warsaw, Poland.
Jacek
J
Przybylski
Department of Internal Medicine, Hypertension and Vascular Diseases, Medical University of Warsaw, Warsaw, Poland.
Piotr
P
Abramczyk
Department of Internal Medicine, Hypertension and Vascular Diseases, Medical University of Warsaw, Warsaw, Poland.
Zbigniew
Z
Gaciong
carotid body chemoreceptors; central blood pressure; hyperoxia
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