Reliability of delivered dialysate sodium concentration.
Background The results of studies investigating the effects of hyponatraemic dialysates have been mixed, with some reporting positive effects including reduction in blood pressure and inter-dialytic weight gains, whereas others have not been able to demonstrate any effect. These studies assume that setting a lower dialysate sodium results in the delivery of a hyponatraemic dialysate. We therefore measured delivered sodium to determine reliability. Methods We measured dialysate sodium in 10 BBraun Dialog+®and 6 Fresenius 4008H dialysis machines, which had been set up to deliver a sodium of 136 mmol/L, using flame photometry and indirect ion selective electrode (ISE) methods. Results Dialysate conductivity was 13.85 ± 0.05 mS/cm, but dialysate sodium measured by flame photometry was 141.8 ± 2.9 mmol/L, and 142.5 ± 2.4 mmol/L by ISE. Both dialysis machines delivered a dialysate sodium in excess of the 136 mmol/L set, with a mean bias of 7.0 ±2.1 mmol/L for the Dialog+®, and 3.7 ± 2.6 for the 4008 with the flame photometer method, and a mean bias of 6.3 ± 1.3 mmol/L for the Dialog+®, and 6.8 ± 3.7 for the 4008 by ISE. Conclusion It is assumed when setting a dialysate sodium concentration that this sodium concentration is delivered. However we found that the dialysate sodium concentration delivered was greater than that set, despite the dialysis machines reporting a conductivity measurement in keeping with a lower sodium dialysate. Trials of lowered dialysate sodium therefore need to measure dialysate sodium concentrations to ensure what has been set is delivered.
UCL Center for Nephrology. nasirul.ekbal@nhs.net.
Nasirul J
NJ
Ekbal
UCL Center for Nephrology. consalus.anne@gmail.com.
Anne
A
Consalus
Department of Clinical Chemistry, University College London Medical School, Royal Free Hospital, Rowland Hill Street, London, NW3 2PF, UK. jahm.persaud@nhs.net.
Jahm
J
Persaud
UCL Center for Nephrology. andrewdavenport@nhs.net.
Andrew
A
Davenport
Dialysis; acute kidney injury; complications; renal replacement therapy