Calcium-Channel Blockers and Dementia Risk in Older Adults　- National Health Insurance Service - Senior Cohort (2002-2013).
Some disagreements surround the effects of calcium-channel blockers (CCBs) on the risk of dementia. The purpose of this study was to investigate the protective effects of CCBs on dementia among elderly hypertensive Koreans.



We conducted a large population-based cohort study using the senior cohort database of the Korean National Health Insurance Service (2002-2013). Subjects were elderly hypertensive Koreans older than 60 years of age. A total of 18,423 patients (CCB user group: 13,692 patients; non-CCB antihypertensive user group: 4,731 patients) were statistically analyzed using the Cox proportional hazard regression model to estimate the adjusted hazard ratio (aHR) and confidence intervals (CIs) of dementia associated with CCB use. There were 2,881 cases (21.0%) of dementia in the CCB user group and 1,124 cases (23.8%) in the non-user group. CCB use significantly reduced the risk of total dementia (aHR 0.81, 95% CI 0.75-0.87, P<0.0001), Alzheimer's dementia (aHR 0.80, 95% CI 0.72-0.88, P<0.0001), and vascular dementia (aHR 0.81, 95% CI 0.70-0.94, P=0.0067).



CCB use had a protective effect on the risk of dementia among elderly hypertensive Koreans. (Circ J 2016; 80: 2336-2342).
Department of Family Medicine, College of Medicine, Kyung Hee University.
Deri
D
Hwang
Sunyoung
S
Kim
Hangseok
H
Choi
In-Hwan
IH
Oh
Byung Sung
BS
Kim
Hyun Rim
HR
Choi
So Yeon
SY
Kim
Chang Won
CW
Won
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000517:prevention & control; D002121:Calcium Channel Blockers / Q000008:administration & dosage*; D015331:Cohort Studies; D015140:Dementia, Vascular / Q000453:epidemiology / Q000517:prevention & control; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000453:epidemiology; D008297:Male; D009313:National Health Programs; D056910:Republic of Korea; D012307:Risk Factors
D002121:Calcium Channel Blockers