Hyperlipidemia sink for anesthetic agents.
We present a case that involves anesthetic resistance during anesthesia for electroconvulsive therapy. Despite adequate dosing of both intravenous and inhalation anesthetics, our patient was resistant to induction of the state of general anesthesia. Subsequently, we noticed extreme hyperlipidemia. We hypothesized that the patient's extreme hyperlipidemia served as an anesthetic "sink" and prevented the full dose of intravenous agents from quickly reaching their intended site of action.
Department of Anesthesiology, University of Buffalo, Buffalo, New York, NY.
Thomas J
TJ
Johnson
Department of Anesthesiology, University of Buffalo, Buffalo, New York, NY. Electronic address: jay12p@yahoo.com.
Jahan
J
Porhomayon
Department of Anesthesiology, University of Buffalo, Buffalo, New York, NY.
Nader D
ND
Nader
Department of Anesthesiology, University of Buffalo, Buffalo, New York, NY.
Enas
E
Eldesouki
Department of Pharmacy, University of Buffalo, Buffalo, New York, NY.
Kelly
K
Smith
Department of Anesthesiology, University of Buffalo, Buffalo, New York, NY.
Geoffrey G
GG
Hobika
D000328:Adult; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D018685:Anesthetics, Inhalation / Q000008:administration & dosage* / Q000493:pharmacokinetics; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000493:pharmacokinetics; D061218:Depressive Disorder, Treatment-Resistant / Q000628:therapy; D004565:Electroconvulsive Therapy; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood*; D008074:Lipoproteins / Q000378:metabolism*; D008297:Male; D008723:Methohexital / Q000008:administration & dosage / Q000493:pharmacokinetics*; D015742:Propofol / Q000008:administration & dosage / Q000493:pharmacokinetics*
D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D008074:Lipoproteins; D008723:Methohexital; D015742:Propofol
Anesthesia; Delay; Hyperlipidemia; Induction; Propofol; Sink