Single Versus Double Lung Retransplantation Does Not Affect Survival Based on Previous Transplant Type.
BACKGROUND
Survival following retransplantation with a single lung is worse than after double lung transplant. We sought to characterize survival of patients who underwent lung retransplantation based on the type of their initial transplant, single or double.


METHODS
The United Network for Organ Sharing database was queried for adult patients who underwent lung retransplantation from 2005 onward. Patients were excluded if they underwent more than one retransplantation. The patient population was divided into 4 groups based on first followed by second transplant type, respectively: single then single, double then single, double then double, and single then double. Descriptive analysis and Kaplan-Meier survival analysis were performed. A p value less than 0.05 was considered significant.


RESULTS
A total of 410 patients underwent retransplantation in the study time period. Overall mean survival for all patients who underwent retransplantation was 1,213 days. Kaplan-Meier survival analysis demonstrated no difference in graft survival between the 4 study groups (p = 0.146).


CONCLUSIONS
There was no significant difference in graft survival between recipients of retransplant with single or double lungs when stratified by previous transplant type. These results suggest that when retransplantation is performed, single lung retransplantation should be considered, regardless of previous transplant type, in an effort to maximize organ resources.
Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Kentucky.
Erin M
EM
Schumer
Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Kentucky.
Jonathan D
JD
Rice
Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Kentucky.
Amanda M
AM
Kistler
Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Kentucky.
Jaimin R
JR
Trivedi
Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Kentucky.
Matthew C
MC
Black
Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Kentucky.
Michael
M
Bousamra
Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Kentucky. Electronic address: victor.vanberkel@louisville.edu.
Victor
V
van Berkel
D000328:Adult; D000368:Aged; D001989:Bronchiolitis Obliterans / Q000401:mortality / Q000601:surgery*; D005260:Female; D006084:Graft Rejection / Q000401:mortality*; D006085:Graft Survival; D006801:Humans; D053208:Kaplan-Meier Estimate; D016040:Lung Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012086:Reoperation; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D013997:Time Factors; D014481:United States / Q000453:epidemiology; D055815:Young Adult