Metastatic sebaceous cell carcinoma, review of the literature and use of electrochemotherapy as possible new treatment modality.
BACKGROUND
Metastatic extraorbital sebaceous carcinoma is a rare event that could involve the head and neck. The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy. The treatment of recurrent or advanced disease is still controversial.


METHODS
Extensive literature search was done, and the treatment options are discussed.


RESULTS
Results. The literature search found several treatment modalities in use for the treatment of metastatic extraorbital sebaceous carcinoma. Electrochemotherapy was not included in the reported treatments. We used this technique for a man of 85 years old with a recurrent and locally metastatic extraorbital sebaceous carcinoma of the scalp. During the period of 8 months, two sessions of electrochemotherapy were employed, which resulted in an objective response of the tumour and good quality of life.


CONCLUSIONS
Electrochemotherapy has shown to be a interesting tools for treatment of metastatic extraorbital sebaceous carcinoma when other radical options are not available or convenient.
University of Turin, Department of Medical Sciences, Section of Dermatology, Turin, Italy; Città della Salute e della Scienza di Torino University Hospital, Department of Oncology, Section of Dermatologic Surgery, Turin, Italy.
Simone
S
Ribero
University of Turin, Department of Medical Sciences, Section of Dermatology, Turin, Italy; Città della Salute e della Scienza di Torino University Hospital, Department of Oncology, Section of Dermatologic Surgery, Turin, Italy.
Eugenio Sportoletti
ES
Baduel
University of Turin, Department of Medical Sciences, Section of Dermatology, Turin, Italy.
Matteo
M
Brizio
Città della Salute e della Scienza di Torino University Hospital, Department of Oncology, Section of Dermatologic Surgery, Turin, Italy.
Franco
F
Picciotto
Unit of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Emi
E
Dika
University of Turin, Department of Medical Sciences, Section of Dermatology, Turin, Italy.
Maria Teresa
MT
Fierro
Città della Salute e della Scienza di Torino University Hospital, Department of Oncology, Section of Dermatologic Surgery, Turin, Italy.
Giuseppe
G
Macripò
University of Turin, Department of Medical Sciences, Section of Dermatology, Turin, Italy.
Pietro
P
Quaglino
electrochemotherapy; extraorbital tumour; head and neck tumour; sebaceous carcinoma
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