Diffusion-weighted breast MRI: Clinical applications and emerging techniques.
Diffusion-weighted MRI (DWI) holds potential to improve the detection and biological characterization of breast cancer. DWI is increasingly being incorporated into breast MRI protocols to address some of the shortcomings of routine clinical breast MRI. Potential benefits include improved differentiation of benign and malignant breast lesions, assessment and prediction of therapeutic efficacy, and noncontrast detection of breast cancer. The breast presents a unique imaging environment with significant physiologic and inter-subject variations, as well as specific challenges to achieving reliable high quality diffusion-weighted MR images. Technical innovations are helping to overcome many of the image quality issues that have limited widespread use of DWI for breast imaging. Advanced modeling approaches to further characterize tissue perfusion, complexity, and glandular organization may expand knowledge and yield improved diagnostic tools.



5 J. Magn. Reson. Imaging 2016 J. Magn. Reson. Imaging 2017;45:337-355.
Department of Radiology, University of Washington School of Medicine, Seattle, Washington, USA.|Breast Imaging, Seattle Cancer Care Alliance, Seattle, Washington, USA.
Savannah C
SC
Partridge
Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.
Noam
N
Nissan
Department of Radiology, University of Washington School of Medicine, Seattle, Washington, USA.|Breast Imaging, Seattle Cancer Care Alliance, Seattle, Washington, USA.
Habib
H
Rahbar
Department of Radiology, University of Washington School of Medicine, Seattle, Washington, USA.|Breast Imaging, Seattle Cancer Care Alliance, Seattle, Washington, USA.
Averi E
AE
Kitsch
Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York, USA.
Eric E
EE
Sigmund
D000465:Algorithms; D001940:Breast / Q000000981:diagnostic imaging* / Q000473:pathology*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods* / Q000639:trends; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted
breast DWI artifacts; breast cancer diagnostics; breast diffusion-weighted MRI; breast physiology; diffusion tensor imaging; intravoxel incoherent motion
N Engl J Med. 2015 Feb 12;372(7):593-5
25671249
J Magn Reson Imaging. 2016 Jul;44(1):130-7
26762608
Eur J Radiol. 2014 Dec;83(12):2137-43
25445896
J Magn Reson Imaging. 2009 Sep;30(3):615-20
19711411
Magn Reson Med. 1997 Oct;38(4):527-33
9324317
Invest Radiol. 2012 May;47(5):284-91
22472798
Br J Radiol. 2016 Aug;89(1064):20160076
27302492
AJR Am J Roentgenol. 2014 May;202(5):W496-502
24758685
Mod Pathol. 2002 Dec;15(12):1348-56
12481017
Eur Radiol. 2013 Oct;23(10):2705-12
23732688
J Vis Exp. 2014 Dec 15;(94):null
25549209
J Magn Reson Imaging. 2002 Jun;15(6):693-704
12112520
Am J Clin Nutr. 1991 Jul;54(1):81-92
2058592
Radiology. 2005 Feb;234(2):517-26
15671005
Radiology. 2012 Apr;263(1):64-76
22438442
J Magn Reson Imaging. 2015 Dec;42(6):1679-88
25946597
Clin Breast Cancer. 2014 Feb;14(1):61-7
24183417
MAGMA. 2014 Apr;27(2):185-93
23999995
Radiology. 1988 Aug;168(2):497-505
3393671
AJR Am J Roentgenol. 2009 Dec;193(6):1716-22
19933670
NMR Biomed. 2004 Jun;17(4):170-80
15229930
Breast Cancer Res Treat. 2016 May;157(1):31-40
27091644
Magn Reson Med. 2001 Sep;46(3):548-54
11550248
Eur Radiol. 2013 Sep;23(9):2420-31
23652844
Radiology. 2015 Oct;277(1):46-55
25938679
Radiology. 2009 Nov;253(2):341-51
19703869
Radiol Med. 2012 Sep;117(6):992-1003
22580812
Clin Breast Cancer. 2015 Oct;15(5):370-80
25891905
Nat Phys. 2011 Jun 1;7(6):508-514
21686083
Br J Radiol. 2016 Jul;89(1063):20160140
27197744
Eur Radiol. 2016 Aug;26(8):2547-58
26615557
Magn Reson Med. 2005 Jun;53(6):1432-40
15906300
Br J Radiol. 2016;89(1060):20150614
26853508
Radiology. 2005 Nov;237(2):429-36
16244250
Eur J Radiol. 2015 Oct;84(10):1888-93
26220915
Invest Radiol. 2015 Feb;50(2):95-100
25333308
Neuroimage. 2011 Sep 1;58(1):177-88
21699989
Radiology. 2015 Jan;274(1):74-84
25341078
Radiology. 2010 Jul;256(1):64-73
20574085
Eur Radiol. 2009 Jul;19(7):1612-20
19288109
Clin Radiol. 2010 Dec;65(12):1005-12
21070905
Radiology. 2011 Aug;260(2):364-72
21633054
J Magn Reson Imaging. 2016 Dec;44(6):1624-1632
27092546
J Magn Reson Imaging. 2011 May;33(5):1063-70
21509862
NMR Biomed. 2010 May;23(4):399-405
20131313
Invest Radiol. 2015 Nov;50(11):766-71
26135017
J Magn Reson Imaging. 2002 Aug;16(2):172-8
12203765
Eur Radiol. 2011 Sep;21(9):2011-9
21562806
Korean J Radiol. 2014 Jul-Aug;15(4):403-10
25053898
Eur Radiol. 2014 Jun;24(6):1197-203
24658871
Magn Reson Med. 2015 Jun;73(6):2163-73
25045867
Eur Radiol. 2014 Nov;24(11):2835-47
25103535
J Magn Reson Imaging. 2015 Dec;42(6):1666-78
25919239
Eur J Radiol. 2013 Dec;82(12):e801-6
24099642
Acad Radiol. 2015 Apr;22(4):430-8
25491740
Magn Reson Imaging. 2014 May;32(4):330-41
24512800
Med Phys. 2015 May;42(5):2249-60
25979019
Eur Radiol. 2016 May;26(5):1466-73
26310582
Radiology. 2016 Jan;278(1):13-32
26690990
Magn Reson Med. 2007 Oct;58(4):643-9
17899602
Magn Reson Med. 2000 Oct;44(4):625-32
11025519
Clin Imaging. 2016 May-Jun;40(3):506-11
27133695
J Magn Reson Imaging. 2015 Jan;41(1):175-82
24353241
Eur Radiol. 2011 Jan;21(1):11-7
20640898
Magn Reson Imaging. 2010 Apr;28(3):320-8
20061111
Magn Reson Imaging Clin N Am. 2013 Aug;21(3):601-24
23928248
Med Phys. 2015 Aug;42(8):4833-9
26233210
Br J Radiol. 2012 Aug;85(1016):e474-9
22128125
J Magn Reson Imaging. 2001 Apr;13(4):534-46
11276097
J Magn Reson Imaging. 2015 Aug;42(2):362-70
25407944
J Magn Reson Imaging. 2015 Jan;41(1):169-74
24273108
Clin Imaging. 2014 Sep-Oct;38(5):633-6
24908365
AJR Am J Roentgenol. 2014 Sep;203(3):674-81
25148175
NMR Biomed. 1997 Oct;10(7):348-52
9471126
Eur Radiol. 2012 Jul;22(7):1512-8
22367471
J Comput Assist Tomogr. 2002 Nov-Dec;26(6):1042-6
12488758
Radiology. 1986 Nov;161(2):401-7
3763909
PLoS One. 2015 Mar 27;10(3):e0122151
25816249
Acta Radiol. 2016 Jun;57(6):651-60
26275624
Magn Reson Med. 2003 Aug;50(2):343-53
12876711
PLoS One. 2014 Nov 18;9(11):e113240
25406010
AJR Am J Roentgenol. 2016 Jul;207 (1):205-16
27077731
Eur J Radiol. 2016 May;85(5):943-9
27130054
Magn Reson Imaging. 2013 Jan;31(1):1-9
22898693
Radiology. 2015 Jun;275(3):630-4
25942418
J Magn Reson. 2002 Apr;155(2):278-92
12036339
Acad Radiol. 2015 Dec;22(12 ):1483-8
26391856
Cancer Imaging. 2014 Apr 22;14:11
25608450
J Magn Reson Imaging. 2015 Dec;42(6):1656-65
25914178
AJR Am J Roentgenol. 2015 Feb;204(2):257-60
25615746
J Natl Cancer Inst. 1998 Jun 17;90(12 ):906-10
9637139
Breast Cancer Res Treat. 2015 Feb;149(3):751-9
25638396
J Magn Reson Imaging. 2010 Mar;31(3):562-70
20187198
J Magn Reson Imaging. 2011 Jan;33(1):102-9
21182127
Chin J Cancer Res. 2015 Apr;27(2):209-17
25937784
Acta Radiol. 2014 Feb;55(1):14-23
23864060
Magn Reson Med. 2015 Oct;74(4):1138-44
25323982
Magn Reson Imaging. 2011 Nov;29(9):1215-21
21920686
J Magn Reson Imaging. 2014 May;39(5):1308-13
24719242
J Mammary Gland Biol Neoplasia. 2002 Jan;7(1):49-66
12160086
Radiology. 2014 Apr;271(1):30-7
24475830
Eur J Radiol. 2016 Jan;85(1):274-8
26547123
Eur Radiol. 2011 Jan;21(1):1-10
20668860
Radiology. 2016 Mar;278(3):689-97
26418516
NMR Biomed. 2010 Jul;23(6):619-23
20232453
NMR Biomed. 2009 Jan;22(1):104-13
18384182
J Ultrasound Med. 2005 Jan;24(1):67-72; quiz 74
15615930
J Magn Reson Imaging. 2014 Sep;40(3):674-81
24214467
Radiology. 2015 Aug;276(2):360-70
25751227
J Magn Reson Imaging. 2015 Sep;42(3):779-87
25580585
Eur J Radiol. 2016 Jun;85(6):1132-7
27161063
J Comput Assist Tomogr. 2009 Jan-Feb;33(1):63-9
19188787
Magn Reson Med. 2011 May;65(5):1437-47
21287591
J Magn Reson Imaging. 2006 Sep;24(3):478-88
16897692
Radiology. 1997 Apr;203(1):145-9
9122383
Acta Radiol. 2016 Jan;57(1):19-24
25638799
J Magn Reson Imaging. 2001 Oct;14(4):433-8
11599068
Eur Radiol. 2012 Jul;22(7):1519-28
22411304
J Magn Reson Imaging. 2016 May;43(5):1122-31
26558851
Magn Reson Med. 1999 Apr;41(4):734-42
10332849
J Magn Reson Imaging. 2016 May;43(5):1111-21
26494124
J Magn Reson Imaging. 2017 Jan;45(1):84-93
27441890
J Magn Reson Imaging. 2014 Oct;40(4):813-23
24273096
Invest Radiol. 2015 Apr;50(4):205-11
25260092
Radiology. 2014 Jun;271(3):672-80
24533873
Magn Reson Med Sci. 2013;12(3):193-9
23857151
J Magn Reson Imaging. 2012 Jul;36(1):139-44
22359367
Radiology. 2011 Feb;258(2):372-9
21131584
Am J Pathol. 1981 Jul;104(1):23-34
7258295
Neuroimage. 2012 Jul 16;61(4):1000-16
22484410
Radiology. 2015 Jan;274(1):66-73
25203132
J Magn Reson Imaging. 2010 Feb;31(2):339-47
20099346
Eur J Radiol. 2013 Dec;82(12):e782-9
24034833
Med Oncol. 2012 Jun;29(2):425-31
21286861
Radiology. 2012 May;263(2):374-82
22517955
Magn Reson Med. 2015 Dec;74(6):1733-9
25522006
J Magn Reson Imaging. 2010 May;31(5):1100-5
20432344
Radiology. 1997 Apr;203(1):137-44
9122382
BMC Cancer. 2010 Dec 29;10:693
21189150