A Randomized Controlled Trial to Increase Navy Bean or Rice Bran Consumption in Colorectal Cancer Survivors.
Consumption of navy beans (NB) and rice bran (RB) have been shown to inhibit colon carcinogenesis. Given the overall poor diet quality in colorectal cancer (CRC) survivors and low reported intake of whole grains and legumes, practical strategies to increase consumption merit attention. This study determined feasibility of increasing NB or RB intake in CRC survivors to increase dietary fiber and examined serum inflammatory biomarkers and telomere lengths. Twenty-nine subjects completed a randomized controlled trial with foods that included cooked NB powder (35 g/day), heat-stabilized RB (30 g/day), or no additional ingredient. Fasting blood, food logs, and gastrointestinal health questionnaires were collected. The amount of NB or RB consumed equated to 4-9% of subjects' daily caloric intake and no major gastrointestinal issues were reported with increased consumption. Dietary fiber amounts increased in NB and RB groups at Weeks 2 and 4 compared to baseline and to control (P ≤ 0.01). Telomere length correlated with age and HDL cholesterol at baseline, and with improved serum amyloid A (SAA) levels at Week 4 (P ≤ 0.05). This study concludes feasibility of increased dietary NB and RB consumption to levels associated with CRC chemoprevention and warrants longer-term investigations with both foods in high-risk populations that include cancer prevention and control outcomes.
a Department of Environmental and Radiological Health Sciences , Colorado State University , Fort Collins , Colorado , USA.
Erica C
EC
Borresen
a Department of Environmental and Radiological Health Sciences , Colorado State University , Fort Collins , Colorado , USA.
Dustin G
DG
Brown
a Department of Environmental and Radiological Health Sciences , Colorado State University , Fort Collins , Colorado , USA.
Greg
G
Harbison
a Department of Environmental and Radiological Health Sciences , Colorado State University , Fort Collins , Colorado , USA.
Lynn
L
Taylor
a Department of Environmental and Radiological Health Sciences , Colorado State University , Fort Collins , Colorado , USA.
Amanda
A
Fairbanks
b University of Colorado Health-North Cancer Clinical Research , Fort Collins , Colorado , USA.
Joanne
J
O'Malia
b University of Colorado Health-North Cancer Clinical Research , Fort Collins , Colorado , USA.
Marlon
M
Bazan
c Department of Clinical Sciences , Colorado State University , Fort Collins , Colorado , USA.
Sangeeta
S
Rao
a Department of Environmental and Radiological Health Sciences , Colorado State University , Fort Collins , Colorado , USA.
Susan M
SM
Bailey
d Department of Food Science and Human Nutrition , Colorado State University , Fort Collins , Colorado , USA.|e Kendall Reagan Nutrition Center , Colorado State University , Fort Collins , Colorado , USA.
Melissa
M
Wdowik
d Department of Food Science and Human Nutrition , Colorado State University , Fort Collins , Colorado , USA.
Tiffany L
TL
Weir
f University of Colorado School of Medicine , Aurora , Colorado , USA.
Regina J
RJ
Brown
a Department of Environmental and Radiological Health Sciences , Colorado State University , Fort Collins , Colorado , USA.|e Kendall Reagan Nutrition Center , Colorado State University , Fort Collins , Colorado , USA.|g University of Colorado Cancer Center , Aurora , Colorado , USA.
Elizabeth P
EP
Ryan
D000368:Aged; D015415:Biomarkers / Q000097:blood; D000073116:Cancer Survivors; D008076:Cholesterol, HDL / Q000097:blood; D015179:Colorectal Neoplasms / Q000150:complications; D004043:Dietary Fiber / Q000494:pharmacology*; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007249:Inflammation / Q000178:diet therapy*; D008297:Male; D008875:Middle Aged; D012275:Oryza; D027805:Phaseolus; D000685:Serum Amyloid A Protein / Q000032:analysis; D059505:Telomere Homeostasis
D015415:Biomarkers; D008076:Cholesterol, HDL; D004043:Dietary Fiber; D000685:Serum Amyloid A Protein
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