Serum protein concentration in low-dose total body irradiation of normal and malnourished rats.
Among the radiotherapeutics' modalities, total body irradiation (TBI) is used as treatment for certain hematological, oncological and immunological diseases. The aim of this study was to evaluate the long-term effects of low-dose TBI on plasma concentration of total protein and albumin using prematurely and undernourished rats as animal model. For this, four groups with 9 animals each were formed: Normal nourished (N); Malnourished (M); Irradiated Normal nourished (IN); Irradiated Malnourished (IM). At the age of 28 days, rats of the IN and IM groups underwent total body gamma irradiation with a source of cobalt-60. Total protein and Albumin in the blood serum was quantified by colorimetry. This research indicates that procedures involving low-dose total body irradiation in children have repercussions in the reduction in body-mass as well as in the plasma levels of total protein and albumin. Our findings reinforce the periodic monitoring of total serum protein and albumin levels as an important tool in long-term follow-up of pediatric patients in treatments associated to total body irradiation.
Núcleo de Educação Física e Ciências do Esporte/Centro Acadêmico de Vitória - CAV/Universidade Federal de Pernambuco - UFPE, Brazil. Electronic address: wilsonvcm@gmail.com.
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WCM
Viana
Departamento de Energia Nuclear - DEN/Centro de Tecnologia e Geociências - CTG/Universidade Federal de Pernambuco - UFPE, Brazil.
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Lambertz
Departamento de Energia Nuclear - DEN/Centro de Tecnologia e Geociências - CTG/Universidade Federal de Pernambuco - UFPE, Brazil.
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Borges
Centro de Radioterapia de Pernambuco CERAPE/Hospital de Câncer de Pernambuco-HCP, Brazil.
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AMO
Neto
Departamento de Fisioterapia - DEFISIO/Centro de Ciências da Saúde/Universidade Federal de Pernambuco - UFPE, Brazil.
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KMFT
Lambertz
Departamento de Energia Nuclear - DEN/Centro de Tecnologia e Geociências - CTG/Universidade Federal de Pernambuco - UFPE, Brazil.
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Amaral
D000818:Animals; D001798:Blood Proteins / Q000032:analysis*; D005260:Female; D008297:Male; D044342:Malnutrition / Q000097:blood*; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000097:blood* / Q000209:etiology*; D051381:Rats; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014916:Whole-Body Irradiation / Q000009:adverse effects*
D001798:Blood Proteins
Albumin; Malnutrition; Serum proteins; Total body irradiation