A polyoxometalate-based supramolecular chemosensor for rapid detection of hydrogen sulfide with dual signals.
Hydrogen sulfide (H2S) has been verified as an important biological mediator in human physiological activities, but its rapid and accurate detection is remaining a challenge. Based on our early work, Eu-containing polyoxometalate/ionic liquid-type gemini surfactant hybrid nanoparticles fabricated by EuW10O36·32H2O (Eu-POM) and 1,2-bis(3-hexadecylimidazolium-1-yl) ethane bromide ([C16-2-C16im]Br2) via ionic self-assembly (ISA) strategy, we modified the hybrids with copper (II) ion and used them as a novel turn-off supramolecular fluorescence probe for H2S immediate response. Although copper (II) ions can cause decrease of the fluorescence intensity, the probe with moderate amount of copper (II) still has a high performance in emission property. The copper (II) ion-modified supramolecular sensor (CSS) shows dual signals in the fluorescence intensity and absorbance for H2S detection, and the detection limit is about1.25μM. Furthermore, CSS displays high selectivity for H2S in the presence of other anions and species (e.g. Cl-, Br-, I-, SO42-, SO32-, S2O32-, AC-, H2O2, HCO3-, l-cysteine, homocysteine and l-glutathione), and also have potential for preferential imaging in vivo. Besides, the fluorescence quenching mechanism of CSS in the presence of H2S was explored. CuS generated by the reaction between Cu2+and H2S was testified to act as a quencher, and the nonradiative resonance energy transfer mechanism was speculated to be responsible for fluorescence quenching. It is anticipated that the as-prepared CSS will be used as an efficient chemosensor for the rapid detection of H2S, which is critical for the diagnosis of some diseases, e.g. Alzhermer's disease, Down's syndrome, and diabetes, etc.
Key Laboratory of Colloid and Interface Chemistry, Shandong University, Ministry of Education, Jinan 250100, PR China.
Yongxian
Y
Guo
Key Laboratory of Colloid and Interface Chemistry, Shandong University, Ministry of Education, Jinan 250100, PR China.
Yanjun
Y
Gong
Key Laboratory of Colloid and Interface Chemistry, Shandong University, Ministry of Education, Jinan 250100, PR China.
Lubin
L
Qi
China Ionic Liquid Laboratory, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, PR China.
Yan'an
Y
Gao
Key Laboratory of Colloid and Interface Chemistry, Shandong University, Ministry of Education, Jinan 250100, PR China. Electronic address: ylmlt@sdu.edu.cn.
Li
L
Yu
D060807:Bioluminescence Resonance Energy Transfer Techniques; D003300:Copper / Q000737:chemistry*; D005063:Europium / Q000737:chemistry*; D006862:Hydrogen Sulfide / Q000032:analysis*; D007093:Imidazoles / Q000737:chemistry*; D052578:Ionic Liquids / Q000737:chemistry*; D057230:Limit of Detection; D012996:Solutions; D017973:Tungsten Compounds / Q000737:chemistry*; D014867:Water; D000099294:Polyoxometalates
D003300:Copper; D005063:Europium; D006862:Hydrogen Sulfide; D007093:Imidazoles; D052578:Ionic Liquids; D012996:Solutions; D017973:Tungsten Compounds; D014867:Water; C102296:polyoxometalate I; D000099294:Polyoxometalates; C017846:cupric sulfide
Dual signals; Hydrogen sulfide; Polyoxometalate; Rapid detection; Supramolecular chemosensor