Nanotechnology: A Valuable Strategy to Improve Bacteriocin Formulations.
Bacteriocins are proteinaceous antibacterial compounds, produced by diverse bacteria, which have been successfully used as: (i) food biopreservative; (ii) anti-biofilm agents; and (iii) additives or alternatives to the currently existing antibiotics, to minimize the risk of emergence of resistant strains. However, there are several limitations that challenge the use of bacteriocins as biopreservatives/antibacterial agents. One of the most promising avenues to overcome these limitations is the use of nanoformulations. This review highlights the practical difficulties with using bacteriocins to control pathogenic microorganisms, and provides an overview on the role of nanotechnology in improving the antimicrobial activity and the physicochemical properties of these peptides.
Department of Biotechnology and Life Sciences, Faculty of Post Graduate Studies for Advanced Sciences, Beni-Suef University Beni-Suef, Egypt.
Hazem A
HA
Fahim
Department of Microbiology and Immunology, Faculty of Pharmacy, Beni-Suef University Beni-Suef, Egypt.
Ahmed S
AS
Khairalla
Department of Microbiology and Immunology, Faculty of Pharmacy, Beni-Suef University Beni-Suef, Egypt.
Ahmed O
AO
El-Gendy
antimicrobial peptides; bacteriocin; biopreservative; drug delivery systems; nanoformulated bacteriocins; nanotechnology
J Antimicrob Chemother. 2004 Sep;54(3):648-53
15282239
Probiotics Antimicrob Proteins. 2010 Mar;2(1):46-51
26780900
Biotechnol Bioeng. 2011 Jul;108(7):1529-36
21337333
Environ Health Perspect. 2005 Jul;113(7):823-39
16002369
Crit Rev Ther Drug Carrier Syst. 2014;31(3):187-217
24940748
Adv Drug Deliv Rev. 1998 Dec 1;34(2-3):171-189
10837677
Pol J Microbiol. 2012;61(2):95-104
23163208
Int J Pharm. 1999 Feb 15;178(2):231-43
10205643
Antimicrob Agents Chemother. 2013 Aug;57(8):3928-35
23733456
Chem Commun (Camb). 2009 Aug 28;(32):4853-5
19652803
Appl Environ Microbiol. 2008 Apr;74(7):1997-2003
18245231
Acta Histochem. 2011 May;113(3):236-47
20199800
Int J Nanomedicine. 2012;7:2767-81
22745541
Braz J Microbiol. 2012 Oct;43(4):1414-8
24031971
J Control Release. 2001 Jul 10;75(1-2):211-24
11451511
Environ Sci Technol. 2011 Mar 1;45(5):1992-8
21314116
J Microencapsul. 1999 Nov-Dec;16(6):687-96
10575621
J Microencapsul. 2006 Jun;23(4):417-33
16854817
Annu Rev Microbiol. 2002;56:117-37
12142491
Biomaterials. 2006 Mar;27(9):2051-9
16307794
Int J Food Microbiol. 2012 Jun 1;156(3):272-7
22554928
Micron. 2007;38(8):841-7
17689087
BioDrugs. 2003;17(4):233-40
12899640
Biochimie. 2002 May-Jun;84(5-6):545-57
12423799
Microb Cell Fact. 2014 Aug 29;13 Suppl 1:S3
25186038
Biomaterials. 1996 Jan;17(2):93-102
8624401
Langmuir. 2011 Apr 5;27(7):4020-8
21401066
J Antimicrob Chemother. 2004 Dec;54(6):1019-24
15537697
Future Microbiol. 2014;9(2):235-48
24571075
J Control Release. 2011 Mar 10;150(2):150-6
21115078
Int J Mol Sci. 2011;12 (4):2158-73
21731433
Appl Microbiol Biotechnol. 1998 Nov;50(5):511-9
9917136
Sci Total Environ. 2007 Feb 15;373(2-3):572-5
17173953
Eur J Pharm Biopharm. 2004 Jan;57(1):123-31
14729088
Probiotics Antimicrob Proteins. 2013 Mar;5(1):43-50
26782604
Biomaterials. 2006 Sep;27(27):4815-24
16725196
Mini Rev Med Chem. 2012 Jul;12(8):731-41
22512554
Biomaterials. 1996 Apr;17 (8):831-9
8730968
Probiotics Antimicrob Proteins. 2015 Mar;7(1):52-9
25319566
Appl Environ Microbiol. 1994 Nov;60(11):4174-7
16349445
ACS Nano. 2009 Jan 27;3(1):16-20
19206243
Carbohydr Polym. 2015 Nov 5;132:582-8
26256385
Crit Rev Ther Drug Carrier Syst. 2009;26(6):523-80
20402623
J Microencapsul. 1995 May-Jun;12(3):229-46
7650588
J Control Release. 2008 Apr 21;127(2):180-7
18314212
Exp Parasitol. 2014 Sep;144:14-21
24929146
Curr Microbiol. 2015 Jul;71(1):24-30
25855302
J Dairy Sci. 1992 Feb;75(2):387-93
1560132
Carbohydr Res. 2001 Jun 22;333(1):1-6
11423105
Int J Pharm. 2004 Dec 9;287(1-2):163-73
15541923
Bacteriol Rev. 1976 Sep;40(3):722-56
791239
Int J Pharm. 2010 Jun 30;393(1-2):212-8
20394813
FEMS Microbiol Rev. 1993 Sep;12(1-3):39-85
8398217
J Biomater Appl. 2001 Jul;16(1):3-21
11475357
Pharm Res. 1993 Aug;10(8):1115-22
8415395
Eur J Pharm Biopharm. 2000 May;49(3):211-8
10799811
Biomaterials. 2006 Mar;27(9):2042-50
16305806
Cancer Lett. 2013 Jul 1;334(2):157-75
22796606
Chem Soc Rev. 2011 Jan;40(1):233-45
20886124
Braz J Microbiol. 2014 May 19;45(1):81-8
24948917
J Appl Microbiol. 2012 Dec;113(6):1407-16
22963007
J Antimicrob Chemother. 2005 Feb;55(2):269-71
15590716
J Mol Biol. 1965 Aug;13(1):238-52
5859039
Food Microbiol. 2010 Feb;27(1):175-8
19913710
Pharm Acta Helv. 1995 Jul;70(2):95-111
7651973
Probiotics Antimicrob Proteins. 2010 Dec;2(4):258-66
26781321
Biotechnol Prog. 2001 Mar-Apr;17(2):366-8
11312717
Int J Food Microbiol. 1997 Jan;34(1):1-16
9029252
Int J Mol Sci. 2013 Jan 14;14(1):1629-54
23344060
J Agric Food Chem. 2003 Dec 31;51(27):8073-9
14690399