APSA Awardee Submission: Tumor/cancer stem cell marker doublecortin-like kinase 1 in liver diseases.
Liver diseases are the fourth leading cause of mortality among adults in the United States. Patients with chronic liver diseases such as viral hepatitis, fibrosis, and cirrhosis have significantly higher risks of developing hepatocellular carcinoma (HCC). With a dismal five-year survival rate of 11%, HCC is the third most common cause of cancer-related deaths worldwide. Regardless of the underlying cause, late presentation and a lack of effective therapy are the major impediments for successful treatment of HCC. Therefore, there is a considerable interest in developing new strategies for the prevention and treatment of chronic liver diseases at the early stages. Cancer stem cells (CSCs), a small cell subpopulation in a tumor, exhibit unlimited self-renewal and differentiation capacity. These cells are believed to play pivotal roles in the initiation, growth, metastasis, and drug-resistance of tumors. In this review, we will briefly discuss pivotal roles of the CSC marker doublecortin-like kinase 1 (DCLK1) in hepatic tumorigenesis. Recent evidence suggests that anti-DCLK1 strategies hold promising clinical potential for the treatment of cancers of the liver, pancreas, and colon.
1 College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Charles B
CB
Nguyen
2 Section of Digestive Diseases and Nutrition, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.|3 Peggy and Charles Stephenson Cancer Center, Oklahoma City, OK 73104, USA.|4 Department of Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA.
Courtney W
CW
Houchen
2 Section of Digestive Diseases and Nutrition, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.|3 Peggy and Charles Stephenson Cancer Center, Oklahoma City, OK 73104, USA.|4 Department of Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA.
Naushad
N
Ali
D014408:Biomarkers, Tumor / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D000089742:Doublecortin-Like Kinases; D058750:Epithelial-Mesenchymal Transition / Q000502:physiology; D006505:Hepatitis / Q000473:pathology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology*; D014411:Neoplastic Stem Cells / Q000473:pathology*; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*
D014408:Biomarkers, Tumor; D047908:Intracellular Signaling Peptides and Proteins; C117347:DCLK1 protein, human; D000089742:Doublecortin-Like Kinases; D017346:Protein Serine-Threonine Kinases
Hepatocellular carcinoma; cancer stem cell; cancer treatment; doublecortin-like kinase 1; epithelial-to-mesenchymal transition; liver diseases
N Engl J Med. 2014 Apr 17;370(16):1483-93
24725238
Cancer Res. 2011 Mar 15;71(6):2328-38
21285251
Cancer Res. 2016 Aug 15;76(16):4887-96
27287718
Cell. 2014 Jun 5;157(6):1324-38
24906150
Am J Physiol Gastrointest Liver Physiol. 2010 Aug;299(2):G303-10
20522640
J Cell Biochem. 2016 May;117(5):1176-86
26477987
Proc Natl Acad Sci U S A. 2012 Jan 17;109 (3):829-34
22207628
Am J Physiol Gastrointest Liver Physiol. 2014 Mar 1;306(5):G404-11
24368703
EMBO J. 2016 Feb 1;35(3):302-18
26758546
Ther Adv Urol. 2016 Feb;8(1):9-18
26834836
BMC Med. 2014 Sep 18;12 :145
25242656
J Biochem. 2011 May;149(5):619-27
21278387
Intervirology. 2014;57(1):23-30
24080608
Dig Dis Sci. 2015 Aug;60(8):2251-63
25840920
FASEB J. 2010 Jun;24(6):1838-51
20097873
Cell Stem Cell. 2014 Sep 4;15(3):340-9
25130492
Nat Commun. 2013;4:1440
23385585
J Antimicrob Chemother. 2010 Apr;65(4):735-40
20118492
J Hepatol. 2016 Oct;65(4):727-33
27349488
CA Cancer J Clin. 2009 Jul-Aug;59(4):225-49
19474385
Oncotarget. 2015 Aug 21;6(24):20327-44
25948779
Hepatology. 2014 Dec;60(6):2099-108
25164003
J Gastroenterol Hepatol. 2012 Apr;27(4):773-80
21916995
J Clin Invest. 2014 Mar;124(3):1283-95
24487592
Blood. 2004 Dec 15;104(13):4260-8
15331440
N Engl J Med. 2008 Jul 24;359(4):378-90
18650514
J Hum Genet. 1998;43(3):169-77
9747029
Nucleic Acids Res. 2014 Jul;42(Web Server issue):W252-8
24782522
Cancer Lett. 2014 Aug 28;351(1):151-61
24880079
J Innate Immun. 2012;4(1):31-40
21912088
Nat Rev Mol Cell Biol. 2014 Jan;15(1):19-33
24326621
J Stem Cells Regen Med. 2014 Apr 30;10(1):2-7
25075155
Cancer Res. 2014 May 1;74(9):2487-98
24626093
Nat Genet. 2013 Jan;45(1):98-103
23202126
Nat Rev Gastroenterol Hepatol. 2010 Aug;7(8):448-58
20628345
Nat Struct Biol. 2003 May;10(5):324-33
12692530
Amino Acids. 2011 Oct;41(4):821-42
20213444
Cancer Gene Ther. 2014 May;21(5):181-7
24787239
J Clin Gastroenterol. 2013 Jul;47 Suppl:S2-6
23632345
Sci Signal. 2013 Apr 02;6(269):pl1
23550210
J Med Virol. 2009 Apr;81(4):619-27
19235854
PLoS One. 2013 Nov 19;8(11):e80304
24260365
Brain Res Mol Brain Res. 2004 Jan 5;120(2):103-14
14741399
PLoS One. 2015 Aug 18;10(8):e0134212
26285154
Hepatol Res. 2013 Feb;43(2):147-54
23145926
J Nanobiotechnology. 2011 Sep 19;9:40
21929751
PLoS Pathog. 2011 Oct;7(10):e1002302
22028650
Curr Opin Gastroenterol. 2013 May;29(3):285-92
23507917
J Biol Chem. 2002 May 17;277(20):17696-705
11884394
Gastroenterology. 2016 Sep;151(3):501-512.e1
27296509
Genomics. 1999 Feb 15;56(1):121-6
10036192
J Viral Hepat. 2013 Sep;20(9):622-7
23910646
Oncol Lett. 2016 Jul;12(1):250-256
27347133
Biomed Res Int. 2014;2014:203693
25089265
World J Hepatol. 2016 Jan 28;8(3):139-47
26839638
Cancer Discov. 2012 May;2(5):401-4
22588877
Int J Cancer. 2010 Dec 15;127(12):2893-917
21351269
J Viral Hepat. 2004 Jul;11(4):302-9
15230852
PLoS One. 2013 Nov 11;8(11):e78675
24244338
Stem Cells. 2014 Mar;32(3):822-7
24123696
Mol Cancer Ther. 2012 Apr;11(4):963-72
22319203
J Immunol. 2003 Mar 15;170(6):3233-42
12626582
Cell Rep. 2014 Aug 21;8(4):933-9
25131204
Clin Transl Med. 2015 Feb 26;4:6
25852822
PLoS Med. 2014 Apr 01;11(4):e1001624
24691105
Sci Rep. 2015 Oct 08;5:14983
26447334
Cell Stem Cell. 2016 Apr 7;18(4):441-55
27058937
Cancer Cell. 2010 Sep 14;18(3):258-67
20832753
Mol Cancer. 2014 May 06;13:103
24885928
N Engl J Med. 2011 Sep 22;365(12):1118-27
21992124
Gastroenterology. 2009 Aug;137(2):649-59, 659.e1-2
19445940
J Virol. 2008 Sep;82(17):8838-48
18562541
J Gastroenterol Hepatol. 2013 Jan;28(1):51-6
22989264
J Virol. 2015 Nov;89(22):11549-56
26355082
J Virol. 2011 Dec;85(23):12292-303
21937640
J Biol Chem. 2001 Sep 28;276(39):36397-403
11473121
Int J Cancer. 2012 Jul 1;131(1):193-200
21805476
Stem Cells. 2008 Mar;26(3):630-7
18055444
Oncotarget. 2015 Nov 10;6(35):37200-15
26468984
J Neurosci. 2000 Dec 15;20(24):9152-61
11124993