Highly Diastereo- and Enantioselective Cu-Catalyzed Borylative Coupling of 1,3-Dienes and Aldimines.
A Cu-catalyzed diastereo- and enantioselective borylative coupling reaction of 1,3-dienes with imines was realized. Branched homoallylic amines are readily prepared in a syn-selective manner with high regio-, diastereo- and enantioselectivity. Moreover, these three-component coupling reactions feature good functional-group compatibility and easy access to the substrates and catalyst.
Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China.|University of Chinese Academy of Sciences, Beijing, 100049, China.
Liyin
L
Jiang
Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China. caopeng@cib.ac.cn.|University of Chinese Academy of Sciences, Beijing, 100049, China. caopeng@cib.ac.cn.
Peng
P
Cao
Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China.|University of Chinese Academy of Sciences, Beijing, 100049, China.
Min
M
Wang
College of Chemical Engineering, Sichuan University, Chengdu, 610065, China.
Bin
B
Chen
Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China.|University of Chinese Academy of Sciences, Beijing, 100049, China.
Bing
B
Wang
Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China. jliao@cib.ac.cn.|University of Chinese Academy of Sciences, Beijing, 100049, China. jliao@cib.ac.cn.|College of Chemical Engineering, Sichuan University, Chengdu, 610065, China. jliao@cib.ac.cn.
Jian
J
Liao
1,3-dienes; asymmetric catalysis; borylative coupling; copper; imines