A review of novel analytical diagnostics for liquid biopsies: spectroscopic and spectrometric serum profiling of primary and secondary brain tumors.
BACKGROUND
Spectroscopic and spectrometric analysis of biological samples is regarded as quick, cost effective, easy to operate, and spectroscopic sample preparation involves minimal sample preparation.


RESULTS
Techniques like infrared (IR) spectroscopy, surface-enhanced laser desorption/ionization (SELDI)-mass spectroscopy (MS), and matrix-assisted laser desorption/ionization (MALDI) -MS could enable early diagnosis of cancer, disease monitoring, and assessment of treatment responses allowing refinement, if required.


CONCLUSIONS
Carrying out analytical testing within outpatient clinics would dramatically cut the time spent by patients attending different appointments, at different locations, save hospital time and resources but importantly would theoretically enable a reduction in mortality and morbidity. While the advantages of such a prospect seem obvious, this review aims to evaluate the use of human serum spectroscopic and spectrometric analysis as a diagnostic tool for brain cancers, creating a platform for the future of cancer diagnostics.
WestCHEM Department of Pure and Applied Chemistry Technology & Innovation Centre University of Strathclyde 99 George Street Glasgow G1 1RD UK.
Katie
K
Spalding
Rosemere Cancer Centre Lancashire Teaching Hospitals NHS Trust Royal Preston Hospital Sharoe Green Lane Preston PR2 9HT UK.
Ruth
R
Board
Neuropathology Lancashire Teaching Hospitals NHS Trust Royal Preston Hospital Sharoe Green Lane North Preston Lancashire PR2 9HT UK.
Timothy
T
Dawson
The Walton Centre for Neurology and Neurosurgery The Walton Centre NHS Foundation Trust Lower Lane Fazakerley Liverpool L9 7LJ UK.
Michael D
MD
Jenkinson
WestCHEM Department of Pure and Applied Chemistry Technology & Innovation Centre University of Strathclyde 99 George Street Glasgow G1 1RD UK.
Matthew J
MJ
Baker
Cancer; infrared; serum; spectrometry; spectroscopy
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