Current advances in the functional studies of fatty acids and fatty acid-derived lipids inC. elegans.
Fatty acids and fatty acid-derived lipids (FAs/FADLs) play essential roles in many living organisms, including contributions to membrane structure and signaling transduction. Aberrant metabolism of FAs/FADLs often causes diseases and health problems. However, the detailed mechanistic studies of specific FAs/FADLsin vivoare limited.C. eleganshas been an effective model system for FA/ FADL studies due to its powerful genetics and conserved lipid biosynthetic pathways. The recently developed high-throughput analytic tools also enable sophisticated profiling of lipids molecules inC. elegans, which is critical for understanding their specific functions. Here we review a subset of current advances in FA/FADL functional studies inC. elegans.
School of Life Science and Technology, ShanghaiTech University , Shanghai, China.
Lu
L
Ying
School of Life Science and Technology, ShanghaiTech University , Shanghai, China.
Huanhu
H
Zhu
C. elegans; aging; fatty acid; fatty acid-derived lipids; reproductive process; stress response
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