[Bone quality in COPD.]
Chronic obstructive pulmonary disease(COPD)is a chronic inflammatory disease associated with an increase of fracture risk. Bone strength is determined by bone mass and quality.Bone quality is thought to encompass the structural and material properties of bone. Bone collagen crosslinking plays important roles in bone strength. The quantitative and qualitative deterioration of lysyl oxidase control and non enzymatic cross-links(advanced glycation end products, AGEs, pentosidine)of collagen in patients with osteoporotic femoral neck fracture and diabetes, and COPD might be affected by increased oxidative stress and glycation.
Department of Orthopaedic Surgery, Jikei University School of Medicine, Japan.
Mitsuru
M
Saito
Department of Orthopaedic Surgery, Jikei University School of Medicine, Japan.
Keishi
K
Marumo
D000818:Animals; D015519:Bone Density / Q000502:physiology*; D001842:Bone and Bones / Q000378:metabolism*; D003094:Collagen / Q000378:metabolism; D006801:Humans; D010024:Osteoporosis / Q000150:complications / Q000209:etiology* / Q000378:metabolism*; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000378:metabolism*; D012307:Risk Factors
D003094:Collagen