Deficit in emotional learning in neurotrimin knockout mice.
Neurotrimin (Ntm) belongs to the IgLON family of cell adhesion molecules with Lsamp, Obcam and kilon that regulate the outgrowth of neurites mostly by forming heterodimers. IgLONs have been associated with psychiatric disorders, intelligence, body weight, heart disease and tumours. This study provides an initial behavioural and pharmacological characterization of the phenotype of Ntm-deficient mice. We expected to see at least some overlap with the phenotype of Lsamp-deficient mice as Ntm and Lsamp are the main interaction partners in the IgLON family and are colocalized in some brain regions. However, Ntm-deficient mice displayed none of the deviations in behaviour that we have previously shown in Lsamp-deficient mice, but differently from Lsamp-deficient mice, had a deficit in emotional learning in the active avoidance task. The only overlap was decreased sensitivity to the locomotor stimulating effect of amphetamine in both knockout models. Thus, despite being interaction partners, on the behavioural level Lsamp seems to play a much more central role than Ntm and the roles of these two proteins seem to be complementary rather than overlapping.
Department of Physiology, Institute of Biomedicine and Translational Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia; Centre of Excellence in Genomics and Translational Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia.
Timur
T
Mazitov
Department of Physiology, Institute of Biomedicine and Translational Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia; Centre of Excellence in Genomics and Translational Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia.
Aleksandr
A
Bregin
Department of Physiology, Institute of Biomedicine and Translational Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia; Centre of Excellence in Genomics and Translational Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia.
Mari-Anne
MA
Philips
Department of Physiology, Institute of Biomedicine and Translational Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia; Centre of Excellence in Genomics and Translational Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia. Electronic address: jurgen.innos@gmail.com.
Jürgen
J
Innos
Department of Physiology, Institute of Biomedicine and Translational Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia; Centre of Excellence in Genomics and Translational Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia.
Eero
E
Vasar
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D001835:Body Weight / Q000187:drug effects; D015816:Cell Adhesion Molecules, Neuronal / Q000172:deficiency / Q000235:genetics; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D003213:Conditioning, Psychological / Q000187:drug effects; D003623:Dark Adaptation / Q000187:drug effects / Q000235:genetics; D004195:Disease Models, Animal; D004644:Emotions / Q000502:physiology*; D005106:Exploratory Behavior / Q000187:drug effects; D005215:Fasting / Q000502:physiology; D005239:Fear / Q000187:drug effects; D058851:GPI-Linked Proteins / Q000172:deficiency / Q000235:genetics; D007859:Learning Disabilities / Q000235:genetics*; D008124:Locomotion / Q000187:drug effects / Q000235:genetics; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D019006:Neural Cell Adhesion Molecules / Q000172:deficiency* / Q000235:genetics; D012018:Reflex / Q000235:genetics
D015816:Cell Adhesion Molecules, Neuronal; D000697:Central Nervous System Stimulants; D058851:GPI-Linked Proteins; D019006:Neural Cell Adhesion Molecules; C095362:limbic system-associated membrane protein; C092530:neurotrimin; D000661:Amphetamine
Behavior; Emotional learning; IgLON; Knockout model; Neurotrimin