Cardiovascular-renal complications and the possible role of plasminogen activator inhibitor: a review.
Since angiotensin increases the expression of plasminogen activator inhibitor (PAI), mechanisms associated with an actively functioning renin-angiotensin-aldosterone system can be expected to be associated with increased PAI-1 expression. These mechanisms are present not only in common conditions resulting in glomerulosclerosis associated with aging, diabetes or genetic mutations, but also in autoimmune disease (like scleroderma and lupus), radiation injury, cyclosporine toxicity, allograft nephropathy and ureteral obstruction. While the renin-angiotensin-aldosterone system and growth factors, such as transforming growth factor-beta (TGF-β), are almost always part of the process, there are rare experimental observations of PAI-1 expression without their interaction. Here we review the literature on PAI-1 and its role in vascular, fibrotic and oxidative injury as well as work suggesting potential areas of intervention in the pathogenesis of multiple disorders.
Joslin Diabetes Center, Boston, MA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
John A
JA
D'Elia
Division ofKidney Diseases and Hypertension, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA; The Miriam Hospital, Providence, RI, USA; Alpert Medical School, Brown University, Providence, RI, USA.
George
G
Bayliss
Joslin Diabetes Center, Boston, MA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA; EP Joslin Research Laboratory, Boston, MA, USA; Brigham and Women's Hospital, Boston, MA, USA.
Ray E
RE
Gleason
Joslin Diabetes Center, Boston, MA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; EP Joslin Research Laboratory, Boston, MA, USA; Brigham and Women's Hospital, Boston, MA, USA.
Larry A
LA
Weinrauch
cardiovascular; end-stage renal disease; renin–angiotensin system; thrombosis; type 2 diabetes
Exp Biol Med (Maywood). 2013 Jan;238(1):37-46
23479762
Circulation. 2013 Nov 19;128(21):2318-24
24092817
Diabetes. 2013 Sep;62(9):3170-9
23715621
Circulation. 2001 Aug 14;104(7):839-44
11502712
Int J Cardiol. 2005 May 11;101(1):19-25
15860378
Clin Appl Thromb Hemost. 2010 Apr;16(2):146-52
19825910
Thorax. 2010 Apr;65(4):334-40
20388759
Circulation. 2001 Jan 30;103(4):576-83
11157725
Am J Physiol Endocrinol Metab. 2006 Jan;290(1):E103-E113
16144810
Exp Biol Med (Maywood). 2012 Jan;237(1):1-9
22238286
Diabetes Care. 2008 May;31(5):940-4
18268065
Exp Nephrol. 1999 Mar-Apr;7(2):147-59
10213868
J Am Soc Nephrol. 2005 Apr;16(4):966-76
15728787
Biochem Biophys Res Commun. 2005 Aug 19;334(1):30-7
15990085
Atherosclerosis. 2012 Sep;224(1):208-12
22840426
Nephrol Dial Transplant. 2010 Jun;25(6):1803-10
20061322
Clin Exp Immunol. 2005 Mar;139(3):429-38
15730388
N Engl J Med. 2015 May 28;372(22):2160-2
26017827
Circ Res. 1988 Apr;62(4):757-65
2964945
J Am Soc Nephrol. 2015 Jun;26(6):1229-31
25326584
Clin Kidney J. 2013 Dec;6(6):599-603
26069829
Circulation. 1997 Jul 15;96(2):442-7
9244210
Curr Med Res Opin. 2009 Aug;25(8):1973-83
19555253
Am Heart J. 1990 Sep;120(3):672-6
2389702
Int J Nephrol Renovasc Dis. 2011;4:1-15
21694944
Metabolism. 2006 Nov;55(11):1464-72
17046548
Thromb Haemost. 2001 Nov;86(5):1305-13
11816722
Ren Fail. 1987;10(2):107-13
3120247
Int Immunopharmacol. 2006 Dec 20;6(13-14):1943-51
17161347
Cardiovasc Res. 1988 Oct;22(10):686-95
2978464
FASEB J. 2002 Feb;16(2):147-54
11818362
Diabetes Care. 2013 Aug;36(8):2408-14
23536583
J Cell Physiol. 2012 Feb;227(2):493-507
21465481
Diabetes. 2000 Apr;49(4):633-9
10871202
Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):393-9
23175674
Circulation. 2010 Jun 8;121(22):2407-18
20497976
Acta Pharmacol Sin. 2012 Jul;33(7):897-908
22659625
Hypertens Res. 2011 May;34(5):623-9
21346767
J Cardiovasc Pharmacol Ther. 2013 Sep;18(5):427-32
23695772
J Clin Invest. 1988 Mar;81(3):730-7
3125227
Nephrol Dial Transplant. 2005 Dec;20(12):2812-9
16221712
Circulation. 2002 Oct 1;106(14):1847-52
12356640
J Clin Endocrinol Metab. 2004 Sep;89(9):4469-73
15356049
Eur J Clin Invest. 1992 Oct;22(10):645-50
1459169
Int J Cardiol. 2012 May 17;157(1):146-8
22464248
Circulation. 2001 Oct 16;104(16):1972-1
11602503
Circulation. 1996 Mar 15;93(6):1073-8
8653825
PLoS One. 2016 Mar 29;11(3):e0150613
27022914
J Am Soc Nephrol. 2015 Jun;26(6):1290-302
25326585
Lancet. 2014 Mar 15;383(9921):999-1008
24084292
Arterioscler Thromb Vasc Biol. 2002 Dec 1;22(12):1978-83
12482822
Methods Find Exp Clin Pharmacol. 2000 Dec;22(10):709-23
11346891
Hypertension. 2001 Mar;37(3):961-6
11244025
J Heart Lung Transplant. 1999 Jul;18(7):693-700
10452346
Thromb Haemost. 1998 Dec;80(6):942-8
9869165
Arterioscler Thromb Vasc Biol. 2006 Jun;26(6):1254-9
16514083
Arterioscler Thromb Vasc Biol. 1997 Nov;17 (11):3208-14
9409313
Circ Res. 1997 Apr;80(4):490-6
9118479
J Biol Chem. 2010 May 21;285(21):16239-47
20228065
Antioxid Redox Signal. 2008 Feb;10(2):303-19
17979497
Cardiovasc Drugs Ther. 1996 May;10(2):119-23
8842503
Diabetes Care. 2014 Jul;37(7):2007-14
24760258
Hypertension. 1995 Apr;25(4 Pt 2):809-13
7536716
Arterioscler Thromb Vasc Biol. 1997 Jan;17(1):26-32
9012633
Exp Physiol. 2014 May 1;99(5):802-15
24443353
Exp Dermatol. 2004 Nov;13(11):708-14
15500643
Kidney Int. 2005 Jun;67(6):2221-38
15882265
Circulation. 1997 May 20;95(10):2380-6
9170400
Braz J Med Biol Res. 2013 Oct;46(10):881-91
24141615
Diabetes. 1997 May;46(5):860-7
9133556
Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):737-43
16373605
Metabolism. 1996 Oct;45(10):1243-7
8843179
Diabetes. 1999 Apr;48(4):890-5
10102708
Kidney Int. 1995 Nov;48(5):1459-68
8544402
Free Radic Biol Med. 2010 Jan 1;48(1):1-15
19800967
J Cell Sci. 2011 Apr 15;124(Pt 8):1224-30
21406565
J Biol Chem. 2006 Jun 2;281(22):15345-51
16554301
Thromb Res. 2006;118(6):709-14
16371233
Thromb Haemost. 2009 Jun;101(6):1060-9
19492148
Kidney Int. 1995 Jun;47(6):1546-57
7643523
J Nephrol. 2001 Nov-Dec;14 Suppl 4:S63-9
11798148
J Mol Cell Cardiol. 2000 Jan;32(1):73-83
10652192
Diabetes Care. 2002 Dec;25(12):2123-8
12453948
J Am Coll Cardiol. 1994 Jul;24(1):67-73
8006284
J Thromb Haemost. 2003 Aug;1(8):1753-7
12911589
Arch Intern Med. 2001 Jan 8;161(1):98-101
11146704
Circulation. 2003 Nov 18;108(20):2517-23
14581407