Transgenerational disruption of functional 5-HT1AR-induced connectivity in the adult mouse brain by traumatic stress in early life.
Traumatic stress in early life is a strong risk factor for psychiatric disorders that can affect individuals across several generations. Although the underlying mechanisms have been proposed to implicate serotonergic transmission in the brain, the neural circuits involved remain poorly delineated. Using pharmacological functional magnetic resonance imaging in mice, we demonstrate that traumatic stress in postnatal life alters 5-HT1Areceptor-evoked local and global functions in both, the exposed animals and their progeny when adult. Disrupted functional connectivity is consistent across generations and match limbic circuits implicated in mood disorders, but also networks not previously linked to traumatic stress. These findings underscore the neurobiology and functional mapping of transgenerational effects of early life experiences.
Laboratory of Neuroepigenetics, University and ETH Zurich, Brain Research Institute, Center for Neuroscience Zürich, Zurich, Switzerland.|Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland.
F
F
Razoux
Laboratory of Neuroepigenetics, University and ETH Zurich, Brain Research Institute, Center for Neuroscience Zürich, Zurich, Switzerland.
H
H
Russig
Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland.
T
T
Mueggler
Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland.
C
C
Baltes
Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland.
K
K
Dikaiou
Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland.|Institute of Pharmacology and Toxicology, University of Zurich, Center for Neuroscience Zürich, Zurich, Switzerland.
M
M
Rudin
Laboratory of Neuroepigenetics, University and ETH Zurich, Brain Research Institute, Center for Neuroscience Zürich, Zurich, Switzerland.
I M
IM
Mansuy
D000328:Adult; D000818:Animals; D001921:Brain / Q000378:metabolism; D001931:Brain Mapping / Q000379:methods; D063132:Connectome / Q000379:methods; D005191:Family Characteristics; D006801:Humans; D001523:Mental Disorders / Q000503:physiopathology; D051379:Mice; D009434:Neural Pathways / Q000503:physiopathology; D009446:Neurobiology / Q000379:methods; D044282:Receptor, Serotonin, 5-HT1A / Q000378:metabolism*; D013315:Stress, Psychological / Q000378:metabolism* / Q000503:physiopathology
D044282:Receptor, Serotonin, 5-HT1A
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