HSV presence in brains of individuals without dementia: the TASTY brain series.
Herpes simplex virus (HSV) type 1 affects a majority of the population and recent evidence suggests involvement in Alzheimer's disease aetiology. We investigated the prevalence of HSV type 1 and 2 in the Tampere Autopsy Study (TASTY) brain samples using PCR and sero-positivity in plasma, and associations with Alzheimer's disease neuropathology. HSV was shown to be present in human brain tissue in 11/584 (1.9%) of samples in the TASTY cohort, of which six had Alzheimer's disease neuropathological amyloid beta (Aβ) aggregations. Additionally, serological data revealed 86% of serum samples tested were IgG-positive for HSV. In conclusion, we report epidemiological evidence of the presence of HSV in brain tissue free from encephalitis symptoms in a cohort most closely representing the general population (a minimum prevalence of 1.9%). Whereas 6/11 samples with HSV DNA in the brain tissue had Aβ aggregations, most of those with Aβ aggregations did not have HSV present in the brain tissue.
Department of Clinical Microbiology, Virology, Umeå University, Umeå 90185, Sweden.
Jan
J
Olsson
Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå 90185, Sweden.
Hugo
H
Lövheim
Department of Clinical Microbiology, Virology, Umeå University, Umeå 90185, Sweden.
Emma
E
Honkala
Department of Forensic Medicine, University of Tampere, Tampere 33520, Finland.
Pekka J
PJ
Karhunen
Department of Clinical Microbiology, Virology, Umeå University, Umeå 90185, Sweden.
Fredrik
F
Elgh
Department of Forensic Medicine, University of Tampere, Tampere 33520, Finland eloise.mikkonen@uta.fi.
Eloise H
0000-0001-7399-9749
EH
Kok
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000378:metabolism; D001921:Brain / Q000473:pathology* / Q000821:virology*; D015331:Cohort Studies; D004279:DNA, Viral / Q000097:blood / Q000235:genetics; D003704:Dementia / Q000097:blood / Q000473:pathology* / Q000821:virology*; D005260:Female; D018259:Herpesvirus 1, Human / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction
D016229:Amyloid beta-Peptides; D004279:DNA, Viral
Alzheimer's disease; Amyloid beta aggregations; Herpes simplex virus; Human brain tissue; PCR detection; Paraffin-embedded samples
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