Urine Levels of Defensin α1 Reflect Kidney Injury in Leptospirosis Patients.
Leptospirosis is a zoonotic disease whose severe forms are often accompanied by kidney dysfunction. In the present study, urinary markers were studied for potential prediction of disease severity. Urine samples from 135 patients with or without leptospirosis at San Lazaro Hospital, the Philippines, were analyzed. Urine levels of defensin α1 (uDA1) were compared with those of neutrophil gelatinase-associated lipocalin (uNGAL) andN-acetyl-β-d-glucosidase (uNAG). Serum creatinine (Cr) was used as a marker of kidney injury. The levels of uDA1/Cr, uNGAL/Cr, and uNAG/Cr were positive in 46%, 90%, and 80% of leptospirosis patients, and 69%, 70%, and 70% of non-leptospirosis patients, respectively. In leptospirosis patients, the correlation of uDA1/Cr, uNGAL/Cr and uNAG/Cr levels with serum Cr werer= 0.3 (p< 0.01),r= 0.29 (p< 0.01), andr= 0.02 (p= 0.81), respectively. uDA1/Cr levels were correlated with uNGAL/Cr levels (r= 0.49,p< 0.01) and uNAG/Cr levels (r= 0.47,p< 0.0001) in leptospirosis patients. These findings suggest that uDA1, uNGAL, and uNAG were elevated in leptospirosis patients and reflected various types of kidney damage. uDA1 and uNGAL can be used to track kidney injury in leptospirosis patients because of their correlation with the serum Cr level.
Disaster-Related Infectious Disease, International Research Institute of Disaster Science, Tohoku University, 980-8575 Sendai, Japan. haorile@gmail.com.|Emerging Infectious Diseases, Department of Internal Medicine, Graduate School of Medicine, Tohoku University, 980-8575 Sendai, Japan. haorile@gmail.com.
Haorile
H
Chagan-Yasutan
Emerging Infectious Diseases, Department of Internal Medicine, Graduate School of Medicine, Tohoku University, 980-8575 Sendai, Japan. chenyue69@hotmail.com.
Yue
Y
Chen
Adult Infectious Disease and Tropical Medicine Department, San Lazaro Hospital, 1003 Manila, Philippines. talea211md@yahoo.com.
Talitha Lea
TL
Lacuesta
National Reference Laboratory for HIV/AIDS, Hepatitis, and other STDs, STD/AIDS Cooperative Central Laboratory, 1003 Manila, Philippines. s_leano@yahoo.com.
Prisca Susan A
PS
Leano
Disaster-Related Infectious Disease, International Research Institute of Disaster Science, Tohoku University, 980-8575 Sendai, Japan. hiwasaki@irides.tohoku.ac.jp.
Hiroko
H
Iwasaki
Emerging Infectious Diseases, Department of Internal Medicine, Graduate School of Medicine, Tohoku University, 980-8575 Sendai, Japan. 009fireman@gmail.com.|Faculty of Medicine, Universitas Padjadjaran, 40161 Bandung, Indonesia. 009fireman@gmail.com.
Firmanto
F
Hanan
Emerging Infectious Diseases, Department of Internal Medicine, Graduate School of Medicine, Tohoku University, 980-8575 Sendai, Japan. tdelsi@yahoo.co.id.|Faculty of Medicine, Universitas Padjadjaran, 40161 Bandung, Indonesia. tdelsi@yahoo.co.id.
Delsi
D
Taurustiati
Research Institute of Pharmacological Therapeutical Development, Otsuka Pharmaceutical Co., Ltd., 771-0192 Tokushima, Japan. ohmoto.yasukazu@otsuka.jp.
Yasukazu
Y
Ohmoto
Disaster-Related Infectious Disease, International Research Institute of Disaster Science, Tohoku University, 980-8575 Sendai, Japan. ya82@yahoo.co.jp.|Emerging Infectious Diseases, Department of Internal Medicine, Graduate School of Medicine, Tohoku University, 980-8575 Sendai, Japan. ya82@yahoo.co.jp.
Yugo
Y
Ashino
Emerging Infectious Diseases, Department of Internal Medicine, Graduate School of Medicine, Tohoku University, 980-8575 Sendai, Japan. hsaitoh9813135@med.tohoku.ac.jp.
Hiroki
H
Saitoh
Division of Integrated Nephrology and Telemedicine, Tohoku Medical Megabank Organization, Tohoku University, 980-8573 Sendai, Japan. kiyo@med.tohoku.ac.jp.
Hideyasu
H
Kiyomoto
Research Center for Zoonosis Control, Hokkaido University, 001-0020 Sapporo, Japan. suzuki@czc.hokudai.ac.jp.|GI-CoRE Global Station for Zoonosis Control, Hokkaido University, 001-0020 Sapporo, Japan. suzuki@czc.hokudai.ac.jp.
Yasuhiko
Y
Suzuki
National Reference Laboratory for HIV/AIDS, Hepatitis, and other STDs, STD/AIDS Cooperative Central Laboratory, 1003 Manila, Philippines. betelan@yahoo.com.
Freda O Elizabeth
FO
Telan
Disaster-Related Infectious Disease, International Research Institute of Disaster Science, Tohoku University, 980-8575 Sendai, Japan. toshatto@med.tohoku.ac.jp.|Emerging Infectious Diseases, Department of Internal Medicine, Graduate School of Medicine, Tohoku University, 980-8575 Sendai, Japan. toshatto@med.tohoku.ac.jp.|Department of Occupational Therapy, Graduate School of Health Science Studies, Kibi International University, 716-8508 Takahashi, Japan. toshatto@med.tohoku.ac.jp.
Toshio
T
Hattori
">d-glucosidase (NAG); N-acetyl-β-; defensin α1; kidney injury; leptospirosis; neutrophil gelatinase-associated lipocalin (NGAL)
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