PCOS women show significantly higher homocysteine level, independent to glucose and E2 level.
BACKGROUND
It is reasonable to think that some biochemical characteristics of follicular fluid (FF) surrounding the oocyte may play a critical role in determining the quality of oocyte and the subsequent potential needed to achieve fertilization and embryo development.


OBJECTIVE
This study was carried out to evaluate the levels of FF homocysteine (Hcy) in IVF candidate polycystic ovary syndrome (PCOS) women and any relationships with FF glucose and estradiol (E2) levels.


METHODS
In this case control study which was performed in Dr. Tizro Day Care and IVF Center 70 infertile patients were enrolled in two groups: comprising 35 PCOS and 35 non PCOS women. Long protocol was performed for all patients. FF Hcy, glucose and E2 levels were analyzed at the time of oocyte retrieval.


RESULTS
It was observed that FF Hcy level was significantly higher in PCOS patients compared with non PCOSs (p<0.01). Observations demonstrated that in PCOS group, the Hcy level increased independent to E2, glucose levels, BMI and age, while the PCOS group showed significantly higher BMI compared with non-PCOS group (p=0.03). However, no significant differences were revealed between groups for FF glucose and E2 levels.


CONCLUSIONS
Present data showed that although FF glucose and E2 levels were constant in PCOS and non PCOS patients, but the FF Hcy levels in PCOS were significantly increased (p=0.01).
Department of Biology, Faculty of Science, Urmia University, Urmia, Iran.
Zahra
Z
Eskandari
Department of Comparative Histology and Embryology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Rajab-Ali
RA
Sadrkhanlou
Department of Biology, Faculty of Science, Urmia University, Urmia, Iran.
Vahid
V
Nejati
Dr. Tizro Day Care and IVF Center, Urmia, Iran.
Gholamreza
G
Tizro
Follicular fluid; Homocysteine; IVF; Polycystic ovarian syndrome
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