Assessment of toxic and endocrine potential of substances migrating from selected toys and baby products.
Analysis of literature data shows that there is limited information about the harmful biological effects of mixture of compounds from the EDC group that are released from the surface of toys and objects intended for children and infants. One of the tools that can be used to obtain such information is appropriate bioanalytical tests. The aim of this research involved determining whether tests that use living organisms as an active element (Vibrio fischeri-Microtox®, Heterocypris incongruens-Ostrocodtoxkit F™ and the XenoScreen YES/YAS™ test of oestrogenic/androgenic activity) can be a tool for estimating the combined toxic effects induced by xenobiotics released from objects intended for children. To reproduce the conditions to which objects are exposed during their use, liquids with a composition corresponding to that of human bodily fluids (artificial sweat and saliva) were used. This research focused on the main parameters influencing the intensification of the migration process (temperature, contact time and composition of the extraction mixture). The studies aimed to estimate the endocrine potential of the extracts showed that compounds released from the surface of studied objects exhibit antagonistic androgenic activity. While on the basis of the results of Microtox® test, one can state that the largest quantity of toxic compounds are released in the first 2 h of using the object. The FTIR spectra analyses confirmed that no degradation of polymeric material took place. On the basis of the results obtained, it was unanimously concluded that contact of the object with bodily fluids may result in the release of a large number of xenobiotics, which has disadvantageous effects on the metabolic processes of the indicator organisms.
Department of Analytical Chemistry, Faculty of Chemistry, Gdańsk University of Technology, 11/12 Narutowicza Str, 80-233, Gdańsk, Poland. natszcze@student.pg.gda.pl.
Natalia
N
Szczepańska
Department of Analytical Chemistry, Faculty of Chemistry, Gdańsk University of Technology, 11/12 Narutowicza Str, 80-233, Gdańsk, Poland.
Jacek
J
Namieśnik
Department of Analytical Chemistry, Faculty of Chemistry, Gdańsk University of Technology, 11/12 Narutowicza Str, 80-233, Gdańsk, Poland.
Błażej
B
Kudłak
D048908:Aliivibrio fischeri / Q000187:drug effects; D000728:Androgens / Q000633:toxicity*; D000818:Animals; D003445:Crustacea / Q000187:drug effects; D004703:Endocrine System / Q000187:drug effects*; D006801:Humans; D007223:Infant; D015370:Infant Equipment; D008954:Models, Biological; D010988:Play and Playthings; D015262:Xenobiotics / Q000633:toxicity*
D000728:Androgens; D015262:Xenobiotics
Artificial human fluids; Children; Endocrine disruptors; Extraction; Migration; Toxicity; Toys
Curr Med Chem. 2012;19(27):4581-94
22876896
Environ Toxicol Chem. 2008 Apr;27(4):864-72
18333677
Mar Pollut Bull. 2012 Dec;64(12):2782-9
23044032
Environ Int. 2014 Apr;65:54-62
24468634
Environ Sci Technol. 2009 Nov 1;43(21):8066-71
19924924
J Hazard Mater. 2013 Feb 15;246-247:96-102
23291335
J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Mar 15;985:103-9
25667041
Environ Pollut. 2015 May;200:77-84
25700334
Ecotoxicol Environ Saf. 2015 Jun;116:29-33
25748519
Talanta. 2015 Jan;132:222-7
25476301
Crit Rev Anal Chem. 2015;45(3):191-200
25849821
Environ Sci Technol. 2009 Jun 1;43(11):4200-6
19569352
Sci Total Environ. 2015 Oct 15;530-531:290-6
26047863
Toxicol In Vitro. 2008 Aug;22(5):1412-7
18400463
Environ Int. 2010 Aug;36(6):557-62
20452023
Birth Defects Res A Clin Mol Teratol. 2010 Oct;88(10):938-44
20568270
Environ Int. 2006 Feb;32(2):265-8
16188318
Sci Total Environ. 2016 Jan 15;541:451-67
26410720
Environ Int. 2016 Feb;87:101-7
26655676
J Hazard Mater. 2014 Apr 30;271:321-30
24641994
Ecotoxicol Environ Saf. 2014 Jun;104:247-53
24726936
Sci Total Environ. 2014 Aug 15;490:807-14
24907615
J Hazard Mater. 2012 Jun 30;221-222:193-8
22575175
Ecotoxicol Environ Saf. 2012 Feb;76(2):162-8
22019310
Neurotoxicology. 2012 Dec;33(6):1410-9
22659293
Talanta. 2011 Sep 30;85(4):2080-8
21872061
J Hazard Mater. 2015 Apr 9;286:589-611
25646754
Environ Monit Assess. 2011 Mar;174(1-4):509-16
20431939