Association between liver failure and hepatic UDP-glucuronosyltransferase activity in dairy cows with follicular cysts.
Uridine 5'-diphospho-glucuronosyltransferase (UGT) liver activity was measured using estradiol-17β as a substrate in dairy cows with follicular cysts. The activity was significantly lower than that in dairy cows with normal estrous cycles (P<0.01). Liver disorders, such as fatty liver and hepatitis, were observed in half cows with follicular cysts, and liver UGT activity was lower than that in cows with normal estrus cycles. In addition, the liver UGT activity was significantly lower in dairy cows with follicular cysts without liver disorders than in dairy cows with normal estrous cycles. Therefore, the cows were divided into those with low, middle and high liver UGT activities, and liver disorder complication rates were investigated. The complication rate was significantly higher in the low- (78.1%) than in the middle- (22.2%) and high-level (8.3%) groups, suggesting that liver disorders are closely associated with the development of follicular cysts in dairy cows and that steroid hormone metabolism is delayed because of reduced liver UGT activity, resulting in follicular cyst formation. We conclude that reduced estradiol-17β glucuronidation in the liver and liver disorders are associated with follicular cyst occurrence in dairy cows.
Laboratory of Theriogenology, College of Bioresouce Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-0880, Japan.
Kouichi
K
Tanemura
Tadatoshi
T
Ohtaki
Yasushi
Y
Kuwahara
Shigehisa
S
Tsumagari
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000201:enzymology / Q000209:etiology*; D004958:Estradiol / Q000378:metabolism*; D030762:Estrous Cycle / Q000378:metabolism; D005260:Female; D005497:Follicular Cyst / Q000201:enzymology / Q000209:etiology / Q000662:veterinary*; D014453:Glucuronosyltransferase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D017093:Liver Failure / Q000150:complications* / Q000201:enzymology; D006080:Ovarian Follicle / Q000378:metabolism
D004958:Estradiol; D014453:Glucuronosyltransferase
J Anim Sci. 1982 Nov;55(5):1147-59
6757234
Reprod Nutr Dev. 2006 Mar-Apr;46(2):105-19
16597418
J Vet Med Sci. 2011 Sep;73(9):1145-9
21566399
Vet Rec. 2006 Aug 12;159(7):197-201
16905732
Animals (Basel). 2015 Aug 18;5(3):793-802
26479386
J Dairy Sci. 2004 Oct;87(10):3105-24
15377589
Domest Anim Endocrinol. 2002 Jul;23(1-2):167-77
12142235
Reprod Domest Anim. 2005 Oct;40(5):460-7
16149953
Drug Metab Dispos. 2012 Feb;40(2):259-66
22031624
J Neuroendocrinol. 1996 Jan;8(1):45-56
8932736
Biochem J. 1977 Mar 15;162(3):545-56
869904
Vet Q. 2006 Sep;28(3):90-104
17052073
J Reprod Dev. 2011 Feb;57(1):17-33
21422734
Res Vet Sci. 1996 Nov;61(3):240-4
8938855
J Dairy Sci. 1991 Dec;74(12):4238-53
1787194
J Reprod Dev. 2007 Oct;53(5):987-93
17690530
J Anim Sci. 1981 Sep;53(3):742-8
7319952
Biol Reprod. 1995 Oct;53(4):890-8
8547485
Biol Reprod. 1997 May;56(5):1205-15
9160720
J Dairy Sci. 1990 Jun;73(6):1537-43
2384618
J Reprod Fertil. 1990 Sep;90(1):37-46
2121974
Biol Reprod. 1997 Jan;56(1):133-42
9002642
Theriogenology. 2000 Oct 15;54(7):1065-74
11131325
Am J Vet Res. 1974 Dec;35(12):1575-6
4473946
J Dairy Sci. 1990 Apr;73(4):938-47
2345204
J Biol Chem. 1951 Nov;193(1):265-75
14907713
J Vet Med Sci. 2016 Jun 1;78(5):755-60
26781845
J Reprod Fertil Suppl. 1999;54:411-24
10692872
Theriogenology. 2006 Jan 7;65(1):17-29
16290258
Vet Q. 1999 Jun;21(3):71-7
10427630