The Role of Long Non-Coding RNAs in Ovarian Cancer.
Ovarian cancer is the most fatal tumor of female's reproductive system, and several genetics and environmental factors are involved in its development. Various studies have already identified some suitable biomarkers to facilitate the early detection, the prognosis evaluation, and the assessment of treatment response. However, the aim of this review is to investigate the role of long non-coding RNAs (lncRNAs) in tumorigenesis process of ovarian cancer and their potential applications as ovarian cancer biomarkers. We performed an online literature search of the MEDLINE/PubMed databases using the keywords, including ovarian cancer, lncRNA, and biomarker. We found that several lncRNAs have been shown to be deregulated in ovarian cancer and the specific mechanism of their enrollment in ovarian cancer has been defined for a few of them. In addition, expression profiling has revealed an association between lncRNAs and patients' survival, metastasis potential, as well as treatment response. Expression profiling and methylation analysis of lncRNAs in ovarian cancer may lead to the identification of novel biomarkers that can help in the classification of patients based on prognosis and treatment response.
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Elahe
E
Nikpayam
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Behnoosh
B
Tasharrofi
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Shaghayegh
S
Sarrafzadeh
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Soudeh
S
Ghafouri-Fard
D014408:Biomarkers, Tumor / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009362:Neoplasm Metastasis / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000235:genetics*
D014408:Biomarkers, Tumor; D062085:RNA, Long Noncoding
Biomarker; Ovarian cancer; lncRNA
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