The association between seizures and deposition of collagen in the brain in porcine Taenia solium neurocysticercosis.
Neurocysticercosis caused by infection with Taenia solium is a significant cause of epilepsy and seizures in humans. The aim of this study was to assess the association between seizures and the deposition of collagen in brain tissue in pigs with T. solium neurocysticercosis. In total 78 brain tissue sections from seven pigs were examined histopathologically i.e. two pigs with epileptic seizures and T. solium cysts, four pigs without seizures but with cysts, and one non-infected control pig. Pigs with epileptic seizures had a larger amount of collagen in their brain tissue, showing as large fibrotic scars and moderate amount of collagen deposited around cysts, compared to pigs without seizures and the negative control pig. Our results indicate that collagen is likely to play a considerable part in the pathogenesis of seizures in T. solium neurocysticercosis.
Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlægevej 100, Frederiksberg C, Denmark.
Nina M
NM
Christensen
Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlægevej 100, Frederiksberg C, Denmark. Electronic address: chiara@sund.ku.dk.
Chiara
C
Trevisan
Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlægevej 100, Frederiksberg C, Denmark.
Páll S
PS
Leifsson
Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlægevej 100, Frederiksberg C, Denmark.
Maria V
MV
Johansen
D000818:Animals; D001921:Brain / Q000469:parasitology / Q000473:pathology; D003094:Collagen / Q000378:metabolism*; D020019:Neurocysticercosis / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D012640:Seizures / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000469:parasitology / Q000473:pathology*; D041201:Taenia solium / Q000502:physiology*
D003094:Collagen
Brain tissue; Epilepsy; Histopathology; Infection; Pigs
J Community Health. 2011 Oct;36(5):698-702
21416341
Infect Immun. 2001 Jul;69(7):4554-60
11401999
J Comp Pathol. 2002 Aug-Oct;127(2-3):186-93
12354530
PLoS Negl Trop Dis. 2010 Nov 02;4(11):e870
21072231
Lancet. 2003 Aug 16;362(9383):547-56
12932389
Vet Parasitol. 2016 Apr 15;220:67-71
26995723
Exp Neurol. 1986 Dec;94(3):519-36
3780905