[Pitfalls in the histopathological diagnostics of endometrial carcinoma and its precursors : Clinically relevant differential diagnoses, avoidance of false positive diagnoses].
Making an incorrect histopathological diagnosis of an endometrial lesion may lead to unwanted loss of fertility and therapy-associated morbidity; therefore, endometrial carcinomas need to be correctly typed and differentiated from hyperplastic precursors, benign lesions and artifacts. Typical diagnostic pitfalls are described in this article. Misdiagnosing endometrial lesions can be avoided by paying thorough attention to gross as well as microscopic features and by taking crucial differential diagnoses into consideration. These are, in particular, well-differentiated endometrioid adenocarcinoma of the endometrium versus atypical endometrial hyperplasia, myoinvasive endometrioid adenocarcinoma versus atypical polypoid adenomyoma and endometrioid carcinoma versus serous carcinoma of the endometrium with a predominantly glandular pattern. It is also important to consider the possibility of a false positive diagnosis of atypical endometrial hyperplasia or carcinoma in cases of biopsy-induced artifacts.
Department of Pathology, Vancouver General Hospital, 910 West 10th Avenue, V5Z 4E3, Vancouver, BC, Canada. pathologie@kommoss.de.
F
F
Kommoss
Institut für Pathologie, LKH Graz Süd-West, Graz, Österreich.
S F
SF
Lax
D018194:Adenomyoma / Q000145:classification / Q000473:pathology; D018269:Carcinoma, Endometrioid / Q000145:classification / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D003951:Diagnostic Errors; D004714:Endometrial Hyperplasia / Q000145:classification / Q000473:pathology; D016889:Endometrial Neoplasms / Q000145:classification* / Q000473:pathology*; D004717:Endometrium / Q000473:pathology; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D011230:Precancerous Conditions / Q000145:classification* / Q000473:pathology*; D014594:Uterine Neoplasms / Q000145:classification / Q000473:pathology*
Adenomyoma; Diagnostic errors; Endometrial hyperplasia; Endometrioid adenocarcinoma; Hyperplasia
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