Predicting episodic memory performance using different biomarkers: results from Argentina-Alzheimer's Disease Neuroimaging Initiative.
OBJECTIVE
Argentina-Alzheimer's Disease Neuroimaging Initiative (Arg-ADNI) is the first ADNI study to be performed in Latin America at a medical center with the appropriate infrastructure. Our objective was to describe baseline characteristics and to examine whether biomarkers related to Alzheimer's disease (AD) physiopathology were associated with worse memory performance.


METHODS
Fifteen controls and 28 mild cognitive impairment and 13 AD dementia subjects were included. For Arg-ADNI, all biomarker parameters and neuropsychological tests of ADNI-II were adopted. Results of positron emission tomography (PET) with fluorodeoxyglucose and11C-Pittsburgh compound-B (PIB-PET) were available from all participants. Cerebrospinal fluid biomarker results were available from 39 subjects.


RESULTS
A total of 56 participants were included and underwent baseline evaluation. The three groups were similar with respect to years of education and sex, and they differed in age (F=5.10,P=0.01). Mean scores for the baseline measurements of the neuropsychological evaluation differed significantly among the three groups atP<0.001, showing a continuum in their neuropsychological performance. No significant correlations were found between the principal measures (long-delay recall, C-Pittsburgh compound-B scan, left hippocampal volume, and APOEε4) and either age, sex, or education (P>0.1). Baseline amyloid deposition and left hippocampal volume separated the three diagnostic groups and correlated with the memory performance (P<0.001).


CONCLUSIONS
Cross-sectional analysis of baseline data revealed links between cognition, structural changes, and biomarkers. Follow-up of a larger and more representative cohort, particularly analyzing cerebrospinal fluid and brain biomarkers, will allow better characterization of AD in our country.
Center of Aging and Memory of Neurological Research Institute (FLENI), Buenos Aires, Argentina.
María Julieta
MJ
Russo
Center of Aging and Memory of Neurological Research Institute (FLENI), Buenos Aires, Argentina.
Gabriela
G
Cohen
Center of Aging and Memory of Neurological Research Institute (FLENI), Buenos Aires, Argentina.
Patricio
P
Chrem Mendez
Center of Aging and Memory of Neurological Research Institute (FLENI), Buenos Aires, Argentina.
Jorge
J
Campos
Center of Aging and Memory of Neurological Research Institute (FLENI), Buenos Aires, Argentina.
Federico E
FE
Nahas
Center of Aging and Memory of Neurological Research Institute (FLENI), Buenos Aires, Argentina.
Ezequiel I
EI
Surace
Center of Aging and Memory of Neurological Research Institute (FLENI), Buenos Aires, Argentina.
Silvia
S
Vazquez
Department of Neurology, State University of New York-Downstate Medical Center, Brooklyn, NY, USA; Neuropsychiatric Epidemiology Unit, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Deborah
D
Gustafson
Center of Aging and Memory of Neurological Research Institute (FLENI), Buenos Aires, Argentina.
Salvador
S
Guinjoan
Center of Aging and Memory of Neurological Research Institute (FLENI), Buenos Aires, Argentina.
Ricardo F
RF
Allegri
Center of Aging and Memory of Neurological Research Institute (FLENI), Buenos Aires, Argentina.
Gustavo
G
Sevlever
Alzheimer’s disease; aging; amyloid imaging; biomarkers; mild cognitive impairment
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