Subjective cognitive decline in cognitively normal elders from the community or from a memory clinic: Differential affective and imaging correlates.
BACKGROUND
Subjective cognitive decline (SCD) could indicate preclinical Alzheimer's disease, but the existing literature is confounded by heterogeneous approaches to studying SCD. We assessed the differential cognitive, affective, and neuroimaging correlates of two aspects of SCD: reporting high cognitive difficulties on a self-rated questionnaire versus consulting at a memory clinic.


METHODS
We compared 28 patients from a memory clinic with isolated SCD, 35 community-recruited elders with similarly high levels of self-reported cognitive difficulties, and 35 community-recruited controls with low self-reported cognitive difficulties.


RESULTS
Increased anxiety and amyloid β deposition were observed in both groups with high self-reported difficulties, whereas subclinical depression and (hippocampal) atrophy were specifically associated with medical help seeking. Cognitive tests showed no group differences.


CONCLUSIONS
These results further validate the concept of SCD in both community- and clinic-based groups. Yet, recruitment methods influence associated biomarkers and affective symptomatology, highlighting the heterogeneous nature of SCD depending on study characteristics.
INSERM, U1077, Caen, France; Université de Caen Normandie, UMR-S1077, Caen, France; Ecole Pratique des Hautes Etudes, UMR-S1077, Caen, France; CHU de Caen, U1077, Caen, France.
Audrey
A
Perrotin
INSERM, U1077, Caen, France; Université de Caen Normandie, UMR-S1077, Caen, France; Ecole Pratique des Hautes Etudes, UMR-S1077, Caen, France; CHU de Caen, U1077, Caen, France. Electronic address: lajoie@cyceron.fr.
Renaud
R
La Joie
INSERM, U1077, Caen, France; Université de Caen Normandie, UMR-S1077, Caen, France; Ecole Pratique des Hautes Etudes, UMR-S1077, Caen, France; CHU de Caen, Service de Neurologie, Caen, France.
Vincent
V
de La Sayette
Université de Caen Normandie, UMR-S1077, Caen, France; CEA, DRF/I2BM, LDM-TEP Group, Caen, France; CNRS, UMR ISTCT 6301, LDM-TEP Group, Caen, France.
Louisa
L
Barré
INSERM, U1077, Caen, France; Université de Caen Normandie, UMR-S1077, Caen, France; Ecole Pratique des Hautes Etudes, UMR-S1077, Caen, France; CHU de Caen, U1077, Caen, France.
Florence
F
Mézenge
INSERM, U1077, Caen, France; Université de Caen Normandie, UMR-S1077, Caen, France; Ecole Pratique des Hautes Etudes, UMR-S1077, Caen, France; CHU de Caen, U1077, Caen, France.
Justine
J
Mutlu
INSERM U930, Université François Rabelais de Tours, CHRU de Tours, Tours, France.
Denis
D
Guilloteau
INSERM, U1077, Caen, France; Université de Caen Normandie, UMR-S1077, Caen, France; Ecole Pratique des Hautes Etudes, UMR-S1077, Caen, France; CHU de Caen, U1077, Caen, France.
Stéphanie
S
Egret
INSERM, U1077, Caen, France; Université de Caen Normandie, UMR-S1077, Caen, France; Ecole Pratique des Hautes Etudes, UMR-S1077, Caen, France; CHU de Caen, U1077, Caen, France.
Francis
F
Eustache
INSERM, U1077, Caen, France; Université de Caen Normandie, UMR-S1077, Caen, France; Ecole Pratique des Hautes Etudes, UMR-S1077, Caen, France; CHU de Caen, U1077, Caen, France.
Gaël
G
Chételat
D000368:Aged; D015415:Biomarkers; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging* / Q000523:psychology*; D005260:Female; D006801:Humans; D057187:Independent Living; D008279:Magnetic Resonance Imaging; D008297:Male; D019964:Mood Disorders / Q000523:psychology; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D049268:Positron-Emission Tomography; D057566:Self Report; D011795:Surveys and Questionnaires
D015415:Biomarkers
Alzheimer's disease; Amyloid β; Anxiety; Atrophy; Cognitive complaint; Depression; Florbetapir-PET; Hippocampus; MRI; Preclinical; Subjective cognitive decline