Extracts of Magnolia Species-Induced Prevention of Diabetic Complications: A Brief Review.
Diabetic complications are the major cause of mortality for the patients with diabetes. Oxidative stress and inflammation have been recognized as important contributors for the development of many diabetic complications, such as diabetic nephropathy, hepatopathy, cardiomyopathy, and other cardiovascular diseases. Several studies have established the anti-inflammatory and oxidative roles of bioactive constituents in Magnolia bark, which has been widely used in the traditional herbal medicines in Chinese society. These findings have attracted various scientists to investigate the effect of bioactive constituents in Magnolia bark on diabetic complications. The aim of this review is to present a systematic overview of bioactive constituents in Magnolia bark that induce the prevention of obesity, hyperglycemia, hyperlipidemia, and diabetic complications, including cardiovascular, liver, and kidney.
Departments of Cardiology at the First Hospital of Jilin University, Changchun 130021, China. zhxzhzxz@163.com.
Xuezhong
X
Zhao
Kosair Children Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA. lifs0624@163.com.|General Hospital of the PLA Rocket Force, Beijing 100088, China. lifs0624@163.com.
Fengsheng
F
Li
National Center for Cardiovascular Diseases China, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China. sunwq1986@hotmail.com.
Wanqing
W
Sun
Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, China Centers for Disease Control, Beijing 100088, China. gaolingxinxin@126.com.
Ling
L
Gao
The Bioland Biotec Co., Ltd., Zhangjiang Modern Medical Device Park, Pudong, Shanghai 201203, China. cuttyfamily@hotmail.com.
Ki Soo
KS
Kim
The Bioland Biotec Co., Ltd., Zhangjiang Modern Medical Device Park, Pudong, Shanghai 201203, China. kaekkt@hotmail.com.
Kyoung Tae
KT
Kim
Kosair Children Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA. L0cai001@louisville.edu.
Lu
L
Cai
Departments of Cardiology at the First Hospital of Jilin University, Changchun 130021, China. zg529@163.com.|Kosair Children Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA. zg529@163.com.
Zhiguo
Z
Zhang
Departments of Cardiology at the First Hospital of Jilin University, Changchun 130021, China. zhengyang@jlu.edu.cn.
Yang
Y
Zheng
D002318:Cardiovascular Diseases / Q000150:complications / Q000517:prevention & control*; D003920:Diabetes Mellitus / Q000473:pathology; D003928:Diabetic Nephropathies / Q000150:complications / Q000517:prevention & control*; D006801:Humans; D006943:Hyperglycemia / Q000150:complications / Q000517:prevention & control; D031566:Magnolia / Q000737:chemistry* / Q000378:metabolism; D008516:Medicine, Chinese Traditional; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*
D010936:Plant Extracts
Magnolia; diabetic complications; oxidative stress
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