Naturally occurring compounds acting as potent anti-metastatic agents and their suppressing effects on Hedgehog and WNT/β-catenin signalling pathways.
Despite numerous remarkable achievements in the field of anti-cancer therapy, tumour relapse and metastasis still remain major obstacles in improvement of overall cancer survival, which may be at least partially owing to epithelial-mesenchymal transition (EMT). Multiple signalling pathways have been identified in EMT; however, it appears that the role of the Hedgehog and WNT/β-catenin pathways are more prominent than others. These are well-known preserved intracellular regulatory pathways of different cellular functions including proliferation, survival, adhesion and differentiation. Over the last few decades, several naturally occurring compounds have been identified to significantly obstruct several intermediates in Hedgehog and WNT/β-catenin signalling, eventually resulting in suppression of signal transduction. This article highlights the current state of knowledge associated with Hedgehog and WNT/β-catenin, their involvement in metastasis through EMT processes and introduction of the most potent naturally occurring agents with capability of suppressing them, eventually overcoming tumour relapse, invasion and metastasis.
Cancer Genetics Department, Breast Cancer Research Center, ACECR, Tehran, Iran.
L
L
Farahmand
Recombinant Proteins Department, Breast Cancer Research Center, ACECR, Tehran, Iran.
B
B
Darvishi
Cancer Genetics Department, Breast Cancer Research Center, ACECR, Tehran, Iran.|Tasnim Biotechnology Research Center (TBRC), school of medicine, AJA University of Medical Sciences, Tehran, Iran.
K
K
Majidzadeh-A
Cancer Alternative and Complementary Medicine Department, Breast Cancer Research Center, ACECR, Tehran, Iran.
A
A
Madjid Ansari
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D016207:Cytokines / Q000378:metabolism; D058750:Epithelial-Mesenchymal Transition / Q000187:drug effects; D053823:Hedgehog Proteins / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction / Q000187:drug effects*; D059016:Tumor Microenvironment; D051153:Wnt Proteins / Q000378:metabolism*; D051176:beta Catenin / Q000378:metabolism*
D000970:Antineoplastic Agents; D016207:Cytokines; D053823:Hedgehog Proteins; D051153:Wnt Proteins; D051176:beta Catenin
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