A pH-responsive asymmetric lipid vesicle as drug carrier.
In order to increase the loading efficiency of drug carriers, here we demonstrated a microfluidic method to fabricate an asymmetric vesicle, which contains trichloro(1H,1H,2H,2H-perfluoroocty-l)silane (TPS) inner leaflet and lipid outer leaflet. The asymmetric vesicle was characterised by fluorescence microscopy and Fourier transform infra-red spectrum. In vitro cytotoxicity of the vesicles carrying 5-fluorouacil (5-FU) has also been studied.
a State Key Laboratory of Urban Water Resource and Environment , School of Chemistry and Chemical Engineering, Harbin Institute of Technology , Harbin , China.
Xunan
X
Zhang
a State Key Laboratory of Urban Water Resource and Environment , School of Chemistry and Chemical Engineering, Harbin Institute of Technology , Harbin , China.
Wei
W
Zong
b School of Life Science and Technology , Harbin Institute of Technology , Harbin , China.
Ying
Y
Hu
b School of Life Science and Technology , Harbin Institute of Technology , Harbin , China.
Nan
N
Luo
c Department of Chemical Engineering , Monash University , Victoria , Australia.
Wenlong
W
Cheng
a State Key Laboratory of Urban Water Resource and Environment , School of Chemistry and Chemical Engineering, Harbin Institute of Technology , Harbin , China.
Xiaojun
X
Han
D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D005472:Fluorouracil / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D056656:Lab-On-A-Chip Devices; D008055:Lipids / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D012821:Silanes / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology
D003603:Cytotoxins; D004337:Drug Carriers; D008055:Lipids; D012821:Silanes; D005472:Fluorouracil
Lipid; asymmetric vesicles; drug delivery; microfluidics; self-assembly