Gout and Osteoarthritis: Associations, Pathophysiology, and Therapeutic Implications.
Osteoarthritis (OA), the most common type of arthritis worldwide, is a degenerative disease of diarthrodial joints resulting in pain, reduced quality of life, and socioeconomic burden. Gout, the most common form of inflammatory arthritis, is a consequence of persistently elevated levels of urate and the formation of proinflammatory monosodium urate crystals in joints. Clinicians have long noted a predilection for both diseases to occur in the same joints. In this review, we provide an overview into research elucidating possible biochemical, mechanical, and immunological relationships between gout and OA. We additionally consider the potential implications of these relationships for OA treatment.
From the Crystal Disease Study Group, Division of Rheumatology, New York University School of Medicine, New York, USA.
Chio
C
Yokose
From the Crystal Disease Study Group, Division of Rheumatology, New York University School of Medicine, New York, USA.
Meng
M
Chen
From the Crystal Disease Study Group, Division of Rheumatology, New York University School of Medicine, New York, USA.
Adey
A
Berhanu
From the Crystal Disease Study Group, Division of Rheumatology, New York University School of Medicine, New York, USA.
Michael H
MH
Pillinger
From the Crystal Disease Study Group, Division of Rheumatology, New York University School of Medicine, New York, USA. Svetlana.KrasnokutskySamuels@nyumc.org.|NYU Hospital for Joint Diseases, 301 East 17th Street, Suite 1410, New York, NY, 10003, USA. Svetlana.KrasnokutskySamuels@nyumc.org.
Svetlana
S
Krasnokutsky
D006073:Gout / Q000276:immunology*; D006801:Humans; D010003:Osteoarthritis / Q000276:immunology*; D011788:Quality of Life
Gout; Osteoarthritis; Uric acid
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