[Semaphorin and osteoporosis.]
Although Semaphorins were originally identified as neuronal axon guidance molecules, recent research has revealed the functions of Semaphorins in many organs, tissues and cells. Among Semaphorin family members, Semaphorin 3A(Sema3A)and Sema4D are highly expressed in bone cells and play critical roles in the regulation of bone homeostasis. Other semaphorins and their receptors are also shown to be involved in bone metabolism. In contrast, the function of Semaphorins expressed in lung is not well understood althogh many of Semaphorins are highly expressed in lung among various tissues examined. As growing evidence reveals that the link between chronic obstructive pulmonary disease(COPD)and osteoporosis, the crosstalk between bone and lung through Semaphorin signaling should be investigated.
Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan.
Mikihito
M
Hayashi
Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University,AMED-CREST, Japan Agency for Medical Research and Development, Precursory Research for Embryonic Science and Technology（PRESTO）, Japan Science and Technology Agency, Japan.
Tomoki
T
Nakashima
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010024:Osteoporosis / Q000378:metabolism*; D039961:Semaphorins / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
D009419:Nerve Tissue Proteins; D039961:Semaphorins