Quantitative assessment of gadolinium deposition in dentate nucleus using quantitative susceptibility mapping.
Gadolinium deposition in dentate nucleus (DN) has been reported after serial administration of gadolinium-based contrast agents (GBCAs). Gadolinium complexes have paramagnetic properties; therefore, we evaluated susceptibility changes of gadolinium deposition in DN using quantitative susceptibility mapping (QSM) for patients after serial administration of GBCAs.



In all, 48 patients with brain tumors, who had had serial GBCA administrations (GBCA group), and 48 healthy volunteers without any history of GBCA administrations (non-GBCA group) were enrolled in this study. Susceptibility values in DN on QSM and DN-to-cerebellum signal intensity ratios on unenhanced T1-weighted images (T1ratios) on 3T were analyzed. The relationship between the number of times of GBCA administrations and susceptibility values or T1ratios were evaluated in the GBCA group.



Susceptibility values at DN in the GBCA group were 0.107 ± 0.029 ppm, and significantly higher than those of the non-GBCA group (0.079 ± 0.025 ppm) (P < 0.0001). T1ratios in DN of the GBCA group were 1.059 ± 0.070, and also significantly higher than that of the non-GBCA group (0.993 ± 0.016) (P < 0.0001). Spearman rank correlation coefficients between susceptibility values and the number of times of linear GBCA administration showed a modest significant correlation (ρ = 0.45, P = 0.0015). There was good correlation between T1ratios and the number of times of linear GBCA administration, as reported previously (ρ = 0.76, P < 0.0001).



Susceptibility values on QSM in DN of the GBCA group, after serial administration of GBCAs, were significantly higher than those of the non-GBCA group. Evidence Level: 3 J. MAGN. RESON. IMAGING 2017;45:1352-1358.
Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Sakyoku, Kyoto, Japan.
Takuya
T
Hinoda
Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Sakyoku, Kyoto, Japan.
Yasutaka
0000-0002-1982-3168
Y
Fushimi
Human Brain Research Center, Kyoto University Graduate School of Medicine, Sakyoku, Kyoto, Japan.
Tomohisa
T
Okada
Department of Neurosurgery, Kyoto University Graduate School of Medicine. Sakyoku, Kyoto, Japan.
Yoshiki
Y
Arakawa
Brain Imaging and Analysis Center and Department of Radiology, Duke University Medical Center, Durham, North Carolina, USA.
Chunlei
C
Liu
Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Sakyoku, Kyoto, Japan.
Akira
0000-0002-8894-3622
A
Yamamoto
Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Sakyoku, Kyoto, Japan.
Tsutomu
T
Okada
Department of Neurosurgery, Kyoto University Graduate School of Medicine. Sakyoku, Kyoto, Japan.
Kazumichi
K
Yoshida
Department of Neurosurgery, Kyoto University Graduate School of Medicine. Sakyoku, Kyoto, Japan.
Susumu
S
Miyamoto
Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Sakyoku, Kyoto, Japan.
Kaori
K
Togashi
D000328:Adult; D000368:Aged; D001931:Brain Mapping / Q000379:methods*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D016022:Case-Control Studies; D002529:Cerebellar Nuclei / Q000000981:diagnostic imaging*; D003287:Contrast Media / Q000737:chemistry*; D005260:Female; D005682:Gadolinium / Q000737:chemistry*; D064368:Healthy Volunteers; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
D003287:Contrast Media; D005682:Gadolinium
dentate nucleus; gadolinium-based contrast agents; magnetic resonance imaging; quantitative susceptibility mapping