ORDB, HORDE, ODORactor and other on-line knowledge resources of olfactory receptor-odorant interactions.
We present here an exploration of the evolution of three well-established, web-based resources dedicated to the dissemination of information related to olfactory receptors (ORs) and their functional ligands, odorants. These resources are: the Olfactory Receptor Database (ORDB), the Human Olfactory Data Explorer (HORDE) and ODORactor. ORDB is a repository of genomic and proteomic information related to ORs and other chemosensory receptors, such as taste and pheromone receptors. Three companion databases closely integrated with ORDB are OdorDB, ORModelDB and OdorMapDB; these resources are part of the SenseLab suite of databases (http://senselab.med.yale.edu). HORDE (http://genome.weizmann.ac.il/horde/) is a semi-automatically populated database of the OR repertoires of human and several mammals. ODORactor (http://mdl.shsmu.edu.cn/ODORactor/) provides information related to OR-odorant interactions from the perspective of the odorant. All three resources are connected to each other via web-links.Database URL: http://senselab.med.yale.edu; http://genome.weizmann.ac.il/horde/; http://mdl.shsmu.edu.cn/ODORactor/.
Department of Neuroscience.
Luis
L
Marenco
Yale Center for Medical Informatics, Yale University School of Medicine, New Haven, CT, USA.
Rixin
R
Wang
Department of Neuroscience.
Robert
R
McDougal
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 76100, Israel.
Tsviya
T
Olender
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 76100, Israel.
Michal
M
Twik
HUGO Gene Nomenclature Committee, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.
Elspeth
E
Bruford
Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai JiaoTong University, School of Medicine, Shanghai, China.
Xinyi
X
Liu
Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai JiaoTong University, School of Medicine, Shanghai, China.
Jian
J
Zhang
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 76100, Israel.
Doron
D
Lancet
Department of Neuroscience.
Gordon
G
Shepherd
Center for Biotechnology and Genomics, Texas Tech University, Lubbock, TX, USA chiquito.crasto@ttu.edu.
Chiquito
C
Crasto
D000818:Animals; D030562:Databases, Protein; D006801:Humans; D009812:Odorants; D040901:Proteomics; D018035:Receptors, Odorant / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*
D018035:Receptors, Odorant
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