Global transcriptional regulator TrmB family members in prokaryotes.
Members of the TrmB family act as global transcriptional regulators for the activation or repression of sugar ABC transporters and central sugar metabolic pathways, including glycolytic, gluconeogenic, and other metabolic pathways, and also as chromosomal stabilizers in archaea. As a relatively newly classified transcriptional regulator family, there is limited experimental evidence for their role in Thermococcales, halophilic archaeon Halobacterium salinarum NRC1, and crenarchaea Sulfolobus strains, despite being one of the extending protein families in archaea. Recently, the protein structures of Pyrococcus furiosus TrmB and TrmBL2 were solved, and the transcriptomic data uncovered by microarray and ChIP-Seq were published. In the present review, recent evidence of the functional roles of TrmB family members in archaea is explained and extended to bacteria.
Department of Biology, Kyung Hee University, Seoul, 02447, Republic of Korea.
Minwook
M
Kim
Department of Biology, Kyung Hee University, Seoul, 02447, Republic of Korea.
Soyoung
S
Park
Department of Biology, Kyung Hee University, Seoul, 02447, Republic of Korea. sungjaelee@khu.ac.kr.|Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, 02447, Republic of Korea. sungjaelee@khu.ac.kr.
Sung-Jae
SJ
Lee
D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D001105:Archaea / Q000145:classification / Q000235:genetics*; D019843:Archaeal Proteins / Q000235:genetics*; D001419:Bacteria / Q000145:classification / Q000235:genetics*; D050260:Carbohydrate Metabolism / Q000235:genetics; D020869:Gene Expression Profiling; D019617:Halobacterium salinarum / Q000235:genetics; D020027:Pyrococcus furiosus / Q000235:genetics; D050436:Regulatory Elements, Transcriptional; D012097:Repressor Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D019709:Thermococcales / Q000145:classification / Q000235:genetics; D014157:Transcription Factors / Q000145:classification / Q000235:genetics*
D018528:ATP-Binding Cassette Transporters; D019843:Archaeal Proteins; D012097:Repressor Proteins; D014157:Transcription Factors
TrmB family members; extremophile; global transcriptional regulator; prokaryote; sugar-binding motif
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