Self-Assembled Nanogels of Cholesterol-Bearing Hydroxypropyl Cellulose: A Thermoresponsive Building Block for Nanogel Tectonic Materials.
Hydroxypropyl cellulose (HPC) is a fascinating polysaccharide to use in developing a nanogel to be a thermoresponsive building unit for nanogel tectonic materials. Cholesterol-bearing HPC (Ch-HPC) self-assembled to form nanogels through hydrophobic interactions of the cholesteryl groups in water. Ch-HPC nanogels had a lower critical solution temperature in line with that of native HPC. The particle size of Ch-HPC nanogels was reversibly controlled by the temperature and salting-out effect. The thermoresponsive property was also observed in Ch-HPC nanogel-cross-linked macrogels. These results suggest that a Ch-HPC nanogel is an attractive building block for thermoresponsive nanogel tectonic materials.
Department of Polymer Chemistry, Graduate School of Engineering and ‡ERATO Bio-nanotransporter Project, Japan Science and Technology Agency (JST), Kyoto University , Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
Yoshiro
Y
Tahara
Department of Polymer Chemistry, Graduate School of Engineering and ‡ERATO Bio-nanotransporter Project, Japan Science and Technology Agency (JST), Kyoto University , Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
Mizuki
M
Sakiyama
Department of Polymer Chemistry, Graduate School of Engineering and ‡ERATO Bio-nanotransporter Project, Japan Science and Technology Agency (JST), Kyoto University , Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
Shigeo
S
Takeda
Department of Polymer Chemistry, Graduate School of Engineering and ‡ERATO Bio-nanotransporter Project, Japan Science and Technology Agency (JST), Kyoto University , Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
Tomoki
T
Nishimura
Department of Polymer Chemistry, Graduate School of Engineering and ‡ERATO Bio-nanotransporter Project, Japan Science and Technology Agency (JST), Kyoto University , Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
Sada-Atsu
SA
Mukai
Department of Polymer Chemistry, Graduate School of Engineering and ‡ERATO Bio-nanotransporter Project, Japan Science and Technology Agency (JST), Kyoto University , Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
Shin-Ichi
SI
Sawada
Department of Polymer Chemistry, Graduate School of Engineering and ‡ERATO Bio-nanotransporter Project, Japan Science and Technology Agency (JST), Kyoto University , Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
Yoshihiro
Y
Sasaki
Department of Polymer Chemistry, Graduate School of Engineering and ‡ERATO Bio-nanotransporter Project, Japan Science and Technology Agency (JST), Kyoto University , Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
Kazunari
K
Akiyoshi