Analysis of LRRK2, SNCA, and ITGA8 Gene Variants with Sporadic Parkinson's Disease Susceptibility in Chinese Han Population.
Background. Parkinson's disease (PD) is an age-related neurodegenerative disease affected by multiple genetic and environmental factors. We performed a case-control study on candidate gene to scrutinize whether genetic variants in LRRK2, SNCA, and ITGA8 genes could be associated with sporadic PD in Chinese Han population. Methods. Five single-nucleotide polymorphisms (SNPs) of LRRK2 (rs1491942), SNCA (rs2301134, rs2301135, and rs356221), and ITGA8 (rs7077361) were selected and genotyped among 583 unrelated PD patients and 558 healthy controls. Results. Rs1491942 of LRRK2 gene had a significantly higher genotype frequency (P = 3.543E - 09) and allelic G/C frequencies (P = 2.601E - 10) in PD patients than controls. Rs2301135 of SNCA gene also showed an obvious difference in genotype frequency (P = 4.394E - 07) and allelic G/C frequencies (P = 9.116E - 13) between PD patients and controls. SNPs rs2301134 and rs356221 of SNCA gene and rs7077361 of ITGA8 gene lacked the significant association with the susceptibility of PD in Chinese Han population. Conclusions. Our study firstly expresses that rs1491942 of LRRK2 and rs2301135 of SNCA gene are substantially associated with sporadic Parkinson's disease in Chinese Han population.
Department of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Jie
J
Fang
The First Clinical Medical College of Fujian Medical University, Fuzhou, China.
Kehui
0000-0002-0030-8393
K
Yi
Department of Neurology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Mingwei
0000-0002-5480-8596
M
Guo
Department of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Xingkai
0000-0003-1842-6387
X
An
Department of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Hongli
0000-0003-0201-4310
H
Qu
Department of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Qing
0000-0002-9726-8913
Q
Lin
Department of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Min
0000-0001-8768-6137
M
Bi
Department of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, China; The First Clinical Medical College of Fujian Medical University, Fuzhou, China.
Qilin
0000-0002-1387-2647
Q
Ma
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