Entropy vs standard clinical monitoring using total intravenous anesthesia during transvaginal oocyte retrieval in patients for in vitro fertilization.
OBJECTIVE
Day care surgery is an important arena for monitors of anesthetic depth where minimizing drug use is essential for rapid turnover. Underdosage, on the other hand, carries the risks of intraoperative awareness and pain. Transvaginal oocyte retrieval (TVOR), often performed under total intravenous anesthesia using propofol and fentanyl in Indian patients, is a procedure of special interest because, in addition to the above concerns, toxic effects of propofol on oocytes have been described. We have studied the role of entropy monitor, a depth of anesthesia monitor, in optomising drug titration and facilitating distinction between analgesic and hypnotic components of anesthesia.


METHODS
Prospective randomized controlled study.


METHODS
Operating theater and postoperative recovery area.


METHODS
One hundred twenty American Society of Anesthesiologists class I and II female patients coming to the IVF centre for TVOR under total intravenous anesthesia using propofol and fentanyl. They were randomly allocated into 2 groups: Group EM (drugs titrated as per entropy values: state entropy and response entropy) and group CM (drugs titrated as per standard clinical monitoring).


METHODS
None.


METHODS
Total propofol consumption (TP), total fentanyl consumption (TF), on-table recovery time (T1), time to discharge (T2), intraoperative awareness (A).


RESULTS
Patients in group EM demonstrated 6.7% lesser consumption of propofol (P= .01), 10.9% more consumption of fentanyl (P= .007) and 1 minute faster recovery on-table (P= .009) as compared to group CM. In the PACU, only 10% patients of group EM required supplemental analgesia as opposed to 28.3% in CM group (P= .01). Time to discharge was similar in both groups and no intraoperative awareness was noted.


CONCLUSIONS
Entropy monitor is a useful tool allowing distinction between analgesic and hypnotic components of general anesthesia in patients undergoing TVOR and facilitating drug titration accordingly. Its impact on intraoperative awareness needs to be further evaluated.
Department of Anaesthesiology, Sanjay Gandhi Post Graduate Institute, Raebareli Road, Lucknow, Uttar Pradesh 226014, India. Electronic address: saitewari.mamc@gmail.com.
Saipriya
S
Tewari
Department of Anaesthesiology, Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi 110002, India.
Poonam
P
Bhadoria
Department of Anaesthesiology, Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi 110002, India.
Sonia
S
Wadhawan
Department of Obstetrics and Gynecology, Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi 110002, India.
Sudha
S
Prasad
Department of Anaesthesiology, Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi 110002, India.
Amit
A
Kohli
D000328:Adult; D000768:Anesthesia, General / Q000379:methods; D000771:Anesthesia, Intravenous / Q000379:methods; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage; D005307:Fertilization in Vitro; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage* / Q000009:adverse effects; D058926:Intraoperative Awareness / Q000517:prevention & control*; D016343:Monitoring, Intraoperative / Q000295:instrumentation* / Q000379:methods*; D054315:Oocyte Retrieval / Q000009:adverse effects* / Q000379:methods; D010146:Pain / Q000517:prevention & control; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects; D011446:Prospective Studies; D013997:Time Factors
D018686:Anesthetics, Intravenous; D006993:Hypnotics and Sedatives; D005283:Fentanyl; D015742:Propofol
Entropy; Intraoperative awareness; Transvaginal oocyte retrieval