Factors associated with pulmonary hypertension and long-term survival in bronchiectasis subjects.
The development of pulmonary hypertension (PH) and its effect on long-term survival in bronchiectasis subjects has not been explored. The present study aims to analyze the factors associated with PH and its effect on long-term survival in bronchiectasis subjects.



We prospectively evaluated 23 bronchiectasis subjects without PH and 16 with PH, as well as 20 healthy volunteers.



Bronchiectasis subjects with PH were more hypoxemic and had a greater number of involved lobes in high resolution computed tomography (HRCT) than did the bronchiectasis subjects without PH (P < 0.001 and P < 0.001, respectively). At three years, the survival rate was 95.7% for bronchiectasis subjects without PH and 56.3% for bronchiectasis with PH, and at 5 years, these rates were 95.7% and 62.5%, respectively (P = 0.002). Multivariate Cox regression analysis revealed that only the Medical Research Council (MRC) dyspnea score was independently related to poor survival in all bronchiectasis subjects (hazard ratio: 6.98; 95% CI: 2.41-20.23; P < 0.00001).



Subjects with PH are more hypoxemic and have a greater number of involvements in the lobes of the lungs. Bronchiectasis subjects with PH have worse survival than do bronchiectasis subjects without PH. MRC dyspnea score is an independent predictor of long-term survival.
Department of Medical Intensive Care Unit, Faculty of Medicine, Hacettepe University, Ankara, Turkey. Electronic address: drserpilgocmen@yahoo.com.
Serpil
S
Öcal
Department of Biochemistry, Faculty of Medicine, Hacettepe University, Ankara, Turkey. Electronic address: oytunportakal@gmail.com.
Oytun
O
Portakal
Department of Koru Hospital, Ankara, Turkey. Electronic address: lion-144@hotmail.com.
Arslan
A
Öcal
Department of Chest Diseases, Faculty of Medicine, Hacettepe University, Ankara, Turkey. Electronic address: ademir68@gmail.com.
Ahmet Uğur
AU
Demir
Department of Medical Intensive Care Unit, Faculty of Medicine, Hacettepe University, Ankara, Turkey. Electronic address: atopeli@hacettepe.edu.tr.
Arzu
A
Topeli
Department of Chest Diseases, Faculty of Medicine, Hacettepe University, Ankara, Turkey. Electronic address: lcoplu@gmail.com.
Lütfi
L
Çöplü
D000328:Adult; D001987:Bronchiectasis / Q000150:complications* / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000378:metabolism; D002986:Clinical Trials as Topic; D004417:Dyspnea / Q000175:diagnosis / Q000209:etiology; D015150:Echocardiography, Doppler / Q000379:methods; D019332:Endothelin-1 / Q000097:blood / Q000652:urine; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications*; D000860:Hypoxia / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood* / Q000378:metabolism; D063868:Patient Outcome Assessment; D011446:Prospective Studies; D012307:Risk Factors; D015996:Survival Rate; D014057:Tomography, X-Ray Computed / Q000379:methods; D014421:Turkey / Q000453:epidemiology; D018497:Ventricular Dysfunction, Right / Q000150:complications / Q000000981:diagnostic imaging
D019332:Endothelin-1; D010100:Oxygen
Bronchiectasis; Dyspnea; Endothelin-1; Hypoxemia; Pulmonary hypertension; Survival