Renal MR angiography and perfusion in the pig using hyperpolarized water.
To study hyperpolarized water as an angiography and perfusion tracer in a large animal model.



Protons dissolved in deuterium oxide (D2O) were hyperpolarized in a SPINlab dissolution dynamic nuclear polarization (dDNP) polarizer and subsequently investigated in vivo in a pig model at 3 Tesla (T). Approximately 15 mL of hyperpolarized water was injected in the renal artery by hand over 4-5 s.



A liquid state polarization of 5.3 ± 0.9% of 3.8 M protons in 15 mL of deuterium oxide was achieved with a T1of 24 ± 1 s. This allowed injection through an arterial catheter into the renal artery and subsequently high-contrast imaging of the entire kidney parenchyma over several seconds. The dynamic images allow quantification of tissue perfusion, with a mean cortical perfusion of 504 ± 123 mL/100 mL/min.



Hyperpolarized water MR imaging was successfully demonstrated as a renal angiography and perfusion method. Quantitative perfusion maps of the kidney were obtained in agreement with literature and control experiments with gadolinium contrast. Magn Reson Med 78:1131-1135, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
Department of Electrical Engineering, Technical University of Denmark, Kgs, Lyngby, Denmark.
Kasper
K
Wigh Lipsø
Department of Clinical Medicine, MR Research Centre, Aarhus University, Aarhus, Denmark.|Danish Diabetes Academy, Odense, Denmark.
Esben Søvsø Szocska
ESS
Hansen
Department of Clinical Medicine, MR Research Centre, Aarhus University, Aarhus, Denmark.|Department of Cardiology - Research, Aarhus University Hospital, Aarhus, Denmark.
Rasmus Stilling
RS
Tougaard
Department of Clinical Medicine, MR Research Centre, Aarhus University, Aarhus, Denmark.
Christoffer
C
Laustsen
Department of Electrical Engineering, Technical University of Denmark, Kgs, Lyngby, Denmark.|GE Healthcare, Brøndby, Denmark.
Jan Henrik
JH
Ardenkjaer-Larsen
D000818:Animals; D017666:Deuterium Oxide / Q000008:administration & dosage / Q000737:chemistry*; D005260:Female; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007668:Kidney / Q000098:blood supply* / Q000000981:diagnostic imaging*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D055420:Perfusion Imaging / Q000379:methods*; D019047:Phantoms, Imaging; D013552:Swine
D017666:Deuterium Oxide
DNP; hyperpolarization; magnetic resonance angiography; perfusion