Genetic barriers in transplantation medicine.
The successful of transplantation is determined by the shared human leukocyte antigens (HLAs) and ABO blood group antigens between donor and recipient. In recent years, killer cell receptor [i.e., killer cell immunoglobulin-like receptor (KIR)] and major histocompatibility complex (MHC) class I chain-related gene molecule (i.e., MICA) were also reported as important determinants of transplant compatibility. At present, several different genotyping techniques (e.g., sequence specific primer and sequence based typing) can be used to characterize blood group, HLA, MICA and KIR and loci. These molecular techniques have several advantages because they do not depend on the availability of anti-sera, cellular expression and have greater specificity and accuracy compared with the antibody-antigen based typing. Nonetheless, these molecular techniques have limited capability to capture increasing number of markers which have been demonstrated to determine donor and recipient compatibility. It is now possible to genotype multiple markers and to the extent of a complete sequencing of the human genome using next generation sequencer (NGS). This high throughput genotyping platform has been tested for HLA, and it is expected that NGS will be used to simultaneously genotype a large number of clinically relevant transplantation genes in near future. This is not far from reality due to the bioinformatics support given by the immunogenetics community and the rigorous improvement in NGS methodology. In addition, new developments in immune tolerance based therapy, donor recruitment strategies and bioengineering are expected to provide significant advances in the field of transplantation medicine.
Hisham A Edinur, Forensic Science Programme, School of Health Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
Hisham A
HA
Edinur
Hisham A Edinur, Forensic Science Programme, School of Health Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
Siti M
SM
Manaf
Hisham A Edinur, Forensic Science Programme, School of Health Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
Nor F
NF
Che Mat
ABO blood group; Graft rejection; Graft vs host disease; Human leukocyte antigen; Killer cell immunoglobulin-like receptor; MICA; Transplantation
Nat Rev Immunol. 2003 Apr;3(4):304-16
12669021
Nat Rev Cancer. 2004 May;4(5):371-80
15122208
Philos Trans R Soc Lond B Biol Sci. 2012 Mar 19;367(1590):800-11
22312047
Drugs. 2009 Jul 30;69(11):1483-512
19634926
Liver Transpl. 2008 Feb;14 (2):202-9
18236395
Am J Transplant. 2007 Jul;7(7):1842-8
17511763
Hum Immunol. 1999 Apr;60(4):323-30
10363723
J Exp Med. 2007 Feb 19;204(2):285-97
17283207
J Clin Pathol. 2010 May;63(5):387-90
20418230
Paediatr Drugs. 2003;5(10 ):699-716
14510627
Am J Transplant. 2007 Dec;7(12):2683-92
17924994
Semin Immunol. 2004 Apr;16(2):119-26
15036235
Int J Immunogenet. 2011 Dec;38(6):463-73
22059555
Transfusion. 2013 Feb;53(2):419-23
23113867
J Exp Med. 2001 Sep 3;194(5):629-44
11535631
Biol Blood Marrow Transplant. 2010 Apr;16(4):533-42
19961944
Transplant Proc. 2005 Mar;37(2):899-902
15848569
Hum Genet. 1996 Jun;97(6):777-83
8641696
Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6259-63
8022771
Immunol Rev. 2011 May;241(1):180-205
21488898
Proc Natl Acad Sci U S A. 2012 May 29;109(22):8676-81
22589303
Transpl Immunol. 2002 Aug;10(2-3):147-64
12216946
Nature. 2007 Nov 22;450(7169):566-9
18033300
Ann Transplant. 1997;2(2):27-44
9869851
Tissue Antigens. 2011 Mar;77(3):206-17
21299525
Nucleic Acids Res. 2010 Jan;38(Database issue):D863-9
19875415
J Immunol. 2002 Feb 1;168(3):1080-6
11801641
Pharmaceuticals (Basel). 2015 May 25;8(2):250-6
26020141
Nat Rev Genet. 2004 Dec;5(12):889-99
15573121
BioDrugs. 1999 May;11(5):333-41
18031143
Tissue Antigens. 2010 Sep;76(3):171-6
20696027
Nucleic Acids Res. 2015 Jan;43(Database issue):D423-31
25414341
J Immunol. 1991 Oct 15;147(8):2461-6
1717561
Transplant Proc. 2008 Jan-Feb;40(1):123-5
18261564
Semin Oncol. 2012 Dec;39(6):629-42
23206840
Am J Transplant. 2003 May;3(5):590-8
12752315
Cytotherapy. 2011 Jan;13(1):98-107
20849361
Blood. 2004 Feb 1;103(3):767-76
12958064
Clin J Am Soc Nephrol. 2016 Feb 5;11(2):332-43
26170177
Transplantation. 2008 Aug 27;86(4):578-89
18724229
Curr Top Microbiol Immunol. 2006;298:225-57
16329188
Blood. 2002 May 15;99(10):3493-9
11986199
J Immunol. 2002 Jun 1;168(11):5558-65
12023351
Stem Cells Int. 2015;2015:724047
26089921
Blood Res. 2015 Dec;50(4):194-203
26770947
J Am Soc Nephrol. 2013 May;24(6):954-66
23539759
Nat Med. 1999 Jun;5(6):686-93
10371508
Eur J Immunogenet. 2002 Feb;29(1):35-46
11841487
Nat Genet. 2007 Sep;39(9):1114-9
17694058
J Immunol. 2004 May 15;172(10 ):6003-10
15128783
Adv Exp Med Biol. 2013;735:233-46
23402031
Int J Clin Pract Suppl. 2015 May;(183):23-8
26177071
J Hum Genet. 2009 Jan;54(1):15-39
19158813
Blood. 2012 Feb 9;119(6):1581-9
22174155
Blood. 2005 Apr 15;105(8):3051-7
15632206
Transplantation. 1996 Apr 15;61(7):997-1004
8623206
Transpl Immunol. 2008 Nov;20(1-2):32-42
18773960
Am J Transplant. 2004 Jun;4(6):905-13
15147424
J Exp Med. 2002 Aug 5;196(3):389-99
12163567
Blood Transfus. 2016 Mar;14 (2):160-7
26674823
Am J Transplant. 2011 Sep;11(9):1771-2
21714847
Transplant Proc. 2015 Mar;47(2):558-65
25769607
Nature. 1975 Mar 20;254(5497):267-9
46595
Am J Transplant. 2005 Mar;5(3):465-74
15707400
J Exp Med. 2001 Mar 5;193(5):607-20
11238591
Biol Blood Marrow Transplant. 2005 Mar;11(3):181-7
15744236
Nat Med. 1999 Nov;5(11):1298-302
10545997
Tissue Antigens. 2009 Nov;74(5):393-403
19845894
J Biol Chem. 1990 Jan 15;265(2):1146-51
2104828
Transpl Int. 2001 Dec;14 (6):396-404
11793037
Tissue Antigens. 2010 Apr;75(4):291-455
20356336
Vox Sang. 2009 Oct;97(3):198-206
19548962
Semin Immunol. 2014 Apr;26(2):173-9
24613727
Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12445-50
8901601
Transplant Proc. 2009 Mar;41(2):663-5
19328950
Clin Dev Immunol. 2013;2013:210506
23762087
Blood. 2008 Sep 1;112(5):2149-55
18577709
Cureus. 2015 Nov 06;7(11):e376
26677426
Methods. 2016 Apr 15;99:112-9
26134528
J Invest Dermatol. 2013 Aug;133(8):e11
23856935
J Clin Oncol. 2010 Feb 20;28(6):955-9
20085940
Transplant Rev (Orlando). 2009 Jan;23(1):34-46
19027615
J Immunol. 2002 Nov 15;169(10):5564-70
12421933
Trends Immunol. 2002 Feb;23(2):81-8
11929131
Br J Anaesth. 2012 Jan;108 Suppl 1:i29-42
22194428
Nat Rev Immunol. 2002 Jun;2(6):389-400
12093005
Science. 1999 Jul 30;285(5428):727-9
10426993
Biol Blood Marrow Transplant. 2015 Sep;21(9):1589-96
25960307
J Transplant. 2012;2012:193724
22577514
Nucleic Acids Res. 2015 Jan;43(Database issue):D784-8
25414323
Immunity. 2008 Apr;28(4):546-58
18387831
Immunogenetics. 2001 Mar;53(2):150-69
11345592
Ann Transplant. 2015 Jul 28;20:424-9
26218888
Blood. 2011 Apr 7;117(14):3921-8
21292771
Nat Rev Immunol. 2012 May 25;12(6):459-71
22627862
Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8789-94
9238056
Circulation. 2004 Dec 21;110(25):3858-65
15611389
Hum Genet. 2009 Dec;126(6):729-42
19727826
Bone Marrow Transplant. 2008 Mar;41(5):473-81
18176612
Transplantation. 2003 Jul 15;76(1):120-9
12865797
J Immunol. 2004 Jul 15;173(2):945-54
15240681
Cell. 2001 Jan 12;104(1):1-4
11163234
Ann Intern Med. 2004 Nov 16;141(10):764-70
15545676
EMBO J. 1989 Aug;8(8):2305-12
2477242
Tissue Antigens. 2012 Apr;79(4):279-86
22296171
N Engl J Med. 2007 Sep 27;357(13):1293-300
17898098
Curr Opin Organ Transplant. 2009 Dec;14(6):643-9
19779342
Int J Organ Transplant Med. 2015;6(3):93-8
26306154
Transplantation. 2011 May 27;91(10):1153-8
21544036
Clin Transplant. 2015 Jul;29(7):573-80
25711849
Trends Immunol. 2001 Jul;22(7):378-85
11429322