title: Mesenchymal Stem Cell-Based Therapy for Kidney Disease: A Review of Clinical Evidence.
abstract: Mesenchymal stem cells form a population of self-renewing, multipotent cells that can be isolated from several tissues. Multiple preclinical studies have demonstrated that the administration of exogenous MSC could prevent renal injury and could promote renal recovery through a series of complex mechanisms, in particular via immunomodulation of the immune system and release of paracrine factors and microvesicles. Due to their therapeutic potentials, MSC are being evaluated as a possible player in treatment of human kidney disease, and an increasing number of clinical trials to assess the safety, feasibility, and efficacy of MSC-based therapy in various kidney diseases have been proposed. In the present review, we will summarize the current knowledge on MSC infusion to treat acute kidney injury, chronic kidney disease, diabetic nephropathy, focal segmental glomerulosclerosis, systemic lupus erythematosus, and kidney transplantation. The data obtained from these clinical trials will provide further insight into safety, feasibility, and efficacy of MSC-based therapy in renal pathologies and allow the design of consensus protocol for clinical purpose.
authors.affiliation: Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies (DENOTHE), Florence, Italy; Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy.
authors.forename: Anna Julie
authors.identifier: 0000-0001-9732-1369
authors.initials: AJ
authors.lastname: Peired
authors.affiliation: Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies (DENOTHE), Florence, Italy; Nephrology Unit, Meyer Children's University Hospital, Florence, Italy.
authors.forename: Alessandro
authors.identifier: 0000-0002-0099-4944
authors.initials: A
authors.lastname: Sisti
authors.affiliation: Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies (DENOTHE), Florence, Italy; Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy; Nephrology Unit, Meyer Children's University Hospital, Florence, Italy.
authors.forename: Paola
authors.identifier: 0000-0002-1774-8088
authors.initials: P
authors.lastname: Romagnani