title: Partial response to imatinib treatment in a patient with unresectable gastrointestinal stromal tumor: A case report and mini literature review.
abstract: The aim of the present study was to evaluate the efficacy and safety of imatinib mesylate in unresectable gastrointestinal stromal tumor (GIST) and to discuss its therapeutic regimen. A patient with unresectable GIST is described, and several key clinical studies are reviewed, including the clinical trials B2222 and S0033, which contain recently reported results of the long-term clinical outcome of imatinib in patients with unresectable or metastatic GIST. The recent results of the two studies demonstrate the long-term efficacy and safety of imatinib for unresectable or metastatic GIST. A positive response to imatinib treatment was observed in the present patient, which is consistent with the data of the B2222 and S0033 trials. However, further long-term, large-scale, multicenter and controlled trials are required to determine the relative efficacy of combining imatinib agents with surgical procedures or administering imatinib alone.
authors.affiliation: Department of Gastrointestinal Surgery, The Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, P.R. China.
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Gastrointestinal Surgery, The Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, P.R. China.
authors.forename: Libo
authors.initials: L
authors.lastname: Feng
authors.affiliation: Department of Gastrointestinal Surgery, The Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, P.R. China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Gastrointestinal Surgery, The Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, P.R. China.
authors.forename: Dong
authors.initials: D
authors.lastname: Xia
authors.affiliation: Department of Gastrointestinal Surgery, The Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, P.R. China.
authors.forename: Liang
authors.initials: L
authors.lastname: Xu
keywords: gastrointestinal stromal tumor; imatinib; literature review; unresectable