title: Propranolol enhances bone healing and implant osseointegration in rats tibiae.
abstract: Propranolol, a non-selective β-blocker widely used to treat cardiovascular conditions, favours bone accrual. Accordingly, we hypothesized that propranolol could be useful for improving bone healing and osseointegration. This in vivo study was designed to investigate the effect of propranolol on bone healing and osseointegration in rats' tibiae.
  
  
  
  On 24 Sprague-Dawley rats, a unicortical defect was created in the right tibial metaphysis of each rat and a custom-made titanium implant was placed in the left tibia. Animals were then assigned into two groups (n = 12, each group) and treated daily with either propranolol (5 mg/kg: subcutaneous) or saline, for 2 weeks. Then, after killing, the volume of the cortical defects (mm3) and the percentages of newly formed bone in the defects, were assessed with microcomputed tomography; bone-implant contact percentage and peri-implant bone volume/tissue volume were assessed by histomorphometry.
  
  
  
  Propranolol-treated rats presented smaller cortical defects (1.56 ± 0.28 mm3versus 2.04 ± 0.29 mm3, p < 0.001) with more bone volume/tissue volume (60.6 ± 7.9% versus 41.1 ± 10.2%, p < 0.001) compared to saline-treated rats. Propranolol also enhanced osseointegration as propranolol-treated rats presented higher bone-implant-contact (65.0 ± 13.1% versus 42.5 ± 8.8%, p < 0.001) and peri-implant bone volume/Tissue volume (73.8 ± 10.1% versus 56.9 ± 5.7%, p = 0.007) than saline-treated rats.
  
  
  
  Propranolol enhanced bone healing and implant osseointegration.
authors.affiliation: Faculty of Dentistry, McGill University, Montreal, QC, Canada.|Division of Oral & Maxillofacial Surgery, McGill University, Montreal, QC, Canada.|College of Dentistry, University of Dammam, Dammam, Saudi Arabia.
authors.forename: Ahmed E
authors.initials: AE
authors.lastname: Al-Subaie
authors.affiliation: Faculty of Dentistry, McGill University, Montreal, QC, Canada.
authors.forename: Marco
authors.initials: M
authors.lastname: Laurenti
authors.affiliation: Faculty of Dentistry, McGill University, Montreal, QC, Canada.
authors.forename: Mohamed-Nur
authors.initials: MN
authors.lastname: Abdallah
authors.affiliation: Faculty of Dentistry, McGill University, Montreal, QC, Canada.
authors.forename: Iskandar
authors.initials: I
authors.lastname: Tamimi
authors.affiliation: Faculty of Dentistry, McGill University, Montreal, QC, Canada.
authors.forename: Farid
authors.initials: F
authors.lastname: Yaghoubi
authors.affiliation: Faculty of Dentistry, McGill University, Montreal, QC, Canada.
authors.forename: Hazem
authors.initials: H
authors.lastname: Eimar
authors.affiliation: Faculty of Dentistry, McGill University, Montreal, QC, Canada.|Division of Oral & Maxillofacial Surgery, McGill University, Montreal, QC, Canada.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Makhoul
authors.affiliation: Faculty of Dentistry, McGill University, Montreal, QC, Canada.
authors.forename: Faleh
authors.initials: F
authors.lastname: Tamimi
mesh_terms: D000818:Animals; D015921:Dental Implants; D016348:Osseointegration; D011433:Propranolol; D051381:Rats; D017207:Rats, Sprague-Dawley; D013977:Tibia; D014025:Titanium; D055114:X-Ray Microtomography
chemical_list: D015921:Dental Implants; D011433:Propranolol; D014025:Titanium
keywords: beta-blockers; bone healing; bone regeneration; osseointegration; propranolol