title: Neurotoxicity induced by arsenic in Gallus Gallus: Regulation of oxidative stress and heat shock protein response.
abstract: Arsenic, a naturally occurring heavy metal pollutant, is one of the functioning risk factors for neurological toxicity in humans. However, little is known about the effects of arsenic on the nervous system of Gallus Gallus. To investigate whether arsenic induce neurotoxicity and influence the oxidative stress and heat shock proteins (Hsps) response in chickens, seventy-two 1-day-old male Hy-line chickens were treated with different doses of arsenic trioxide (As2O3). The histological changes, antioxidant enzyme activity, and the expressions of Hsps were detected. Results showed slightly histology changes were obvious in the brain tissues exposure to arsenic. The activities of Glutathione peroxidase (GSH-Px) and catalase (CAT) were decreased compared to the control, whereas the malondialdehyde (MDA) content was increased gradually along with increase in diet-arsenic. The mRNA levels of Hsps and protein expressions of Hsp60 and Hsp70 were up-regulated. These results suggested that sub-chronic exposure to arsenic induced neurotoxicity in chickens. Arsenic exposure disturbed the balance of oxidants and antioxidants. Increased heat shock response tried to protect chicken brain tissues from tissues damage caused by oxidative stress. The mechanisms of neurotoxicity induced by arsenic include oxidative stress and heat shock protein response in chicken brain tissues.
authors.affiliation: College of Wildlife Resources, Northeast Forestry University, Harbin 150040, Heilongjiang Province, China. Electronic address: zpp13796033057@163.com.
authors.forename: Panpan
authors.initials: P
authors.lastname: Zhao
authors.affiliation: College of Wildlife Resources, Northeast Forestry University, Harbin 150040, Heilongjiang Province, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Guo
authors.affiliation: College of Wildlife Resources, Northeast Forestry University, Harbin 150040, Heilongjiang Province, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
authors.affiliation: College of Wildlife Resources, Northeast Forestry University, Harbin 150040, Heilongjiang Province, China.
authors.forename: Hongliang
authors.initials: H
authors.lastname: Chai
authors.affiliation: College of Veteriary Medicine, Northeast Agricultural University, Harbin 150030, Heilongjiang Province, China. Electronic address: 465604393@qq.com.
authors.forename: Houjuan
authors.initials: H
authors.lastname: Xing
authors.affiliation: College of Wildlife Resources, Northeast Forestry University, Harbin 150040, Heilongjiang Province, China. Electronic address: xingmingweinefu@sina.com.
authors.forename: Mingwei
authors.initials: M
authors.lastname: Xing
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001151:Arsenic / Q000633:toxicity*; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000737:chemistry; D001921:Brain / Q000187:drug effects*; D002374:Catalase / Q000378:metabolism; D002645:Chickens / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000235:genetics*; D018869:Heat-Shock Response; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009498:Neurotoxins / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects*; D010087:Oxides / Q000633:toxicity; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D000975:Antioxidants; D001152:Arsenicals; D018840:HSP70 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D009498:Neurotoxins; D010087:Oxides; D012333:RNA, Messenger; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D001151:Arsenic; D000077237:Arsenic Trioxide
keywords: Arsenic; Brain tissues; Heat shock proteins; Oxidative stress