title: Risk factors for treatment-related adverse events in cancer-bearing dogs receiving piroxicam.
abstract: Piroxicam has antitumour effects in dogs with cancer, although side effects may limit its use. The purpose of this study was to retrospectively identify factors predisposing cancer-bearing dogs to adverse events (AEs) following piroxicam therapy. Medical records of dogs presented to the Purdue Veterinary Teaching Hospital between 2005 and 2015 were reviewed, and 137 dogs met the criteria for study inclusion. Toxic effects of piroxicam in these dogs were graded according to an established system. Multivariate logistic regression was used to estimate the extent to which certain factors affected the risk for AEs. Age [odds ratio (OR) 1.250, P = 0.009; 95% confidence interval (CI) 1.057-1.479] and concurrent use of gastroprotectant medications (OR 2.612, P = 0.025; 95% CI 1.127-6.056) significantly increased the risk for gastrointestinal AEs. The results of this study may help inform the risk versus benefit calculation for clinicians considering the use of piroxicam to treat dogs with cancer.
authors.affiliation: Veterinary Teaching Hospital, Purdue University, West Lafayette, IN, USA.
authors.forename: L R
authors.initials: LR
authors.lastname: Eichstadt
authors.affiliation: Department of Veterinary Administration, Purdue University, West Lafayette, IN, USA.
authors.forename: G E
authors.initials: GE
authors.lastname: Moore
authors.affiliation: Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN, USA.
authors.forename: M O
authors.initials: MO
authors.lastname: Childress
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D041981:Gastrointestinal Tract / Q000187:drug effects; D007668:Kidney / Q000187:drug effects; D008297:Male; D009369:Neoplasms / Q000188:drug therapy / Q000662:veterinary*; D010894:Piroxicam / Q000009:adverse effects* / Q000627:therapeutic use; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000970:Antineoplastic Agents; D010894:Piroxicam
keywords: NSAID; chemotherapy; metronomic; transitional cell carcinoma