title: Beyond Reproduction: Pituitary Hormone Actions on Bone.
abstract: The long-held belief that pituitary hormones act solely on master targets was first questioned when we documented G protein-coupled receptors for thyroid-stimulating hormone, follicle-stimulating hormone, adrenocorticotrophic hormone, oxytocin, and vasopressin on bone cells. These evolutionarily conserved hormones and their receptors are known to have primitive roles, and exist in invertebrate species as far down as coelenterates. It is not surprising therefore that each such hormone has multiple hitherto unrecognized functions in mammalian integrative physiology, and hence, becomes a potential target for therapeutic intervention. Here we discuss the skeletal actions of pituitary hormones.
authors.affiliation: The Mount Sinai Bone Program, Department of Medicine, and Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
authors.forename: T
authors.initials: T
authors.lastname: Yuen
authors.affiliation: The Mount Sinai Bone Program, Department of Medicine, and Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
authors.forename: L
authors.initials: L
authors.lastname: Sun
authors.affiliation: The Mount Sinai Bone Program, Department of Medicine, and Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
authors.forename: P
authors.initials: P
authors.lastname: Liu
authors.affiliation: Departments of Pathology and of Cell Biology, University of Pittsburgh School of Medicine and the Pittsburgh VA Medical Center, Pittsburgh, PA, United States.
authors.forename: H C
authors.initials: HC
authors.lastname: Blair
authors.affiliation: The Mount Sinai Bone Program, Department of Medicine, and Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
authors.forename: M
authors.initials: M
authors.lastname: New
authors.affiliation: Department of Histology, University of Bari, Bari, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Zallone
authors.affiliation: The Mount Sinai Bone Program, Department of Medicine, and Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address: mone.zaidi@mountsinai.org.
authors.forename: M
authors.initials: M
authors.lastname: Zaidi
mesh_terms: D000818:Animals; D005075:Biological Evolution; D001862:Bone Resorption / Q000473:pathology; D001842:Bone and Bones / Q000187:drug effects*; D006801:Humans; D010907:Pituitary Hormones / Q000494:pharmacology*; D012098:Reproduction / Q000187:drug effects*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D010907:Pituitary Hormones
keywords: bone; follitropin; osteoblast; osteoclast; osteoporosis; thyrotropin