title: Unique Features of Ethnic Mongolian Gut Microbiome revealed by metagenomic analysis.
abstract: The human gut microbiota varies considerably among world populations due to a variety of factors including genetic background, diet, cultural habits and socioeconomic status. Here we characterized 110 healthy Mongolian adults gut microbiota by shotgun metagenomic sequencing and compared the intestinal microbiome among Mongolians, the Hans and European cohorts. The results showed that the taxonomic profile of intestinal microbiome among cohorts revealed the Actinobaceria and Bifidobacterium were the key microbes contributing to the differences among Mongolians, the Hans and Europeans at the phylum level and genus level, respectively. Metagenomic species analysis indicated that Faecalibacterium prausnitzii and Coprococcus comeswere enrich in Mongolian people which might contribute to gut health through anti-inflammatory properties and butyrate production, respectively. On the other hand, the enriched genus Collinsella, biomarker in symptomatic atherosclerosis patients, might be associated with the high morbidity of cardiovascular and cerebrovascular diseases in Mongolian adults. At the functional level, a unique microbial metabolic pathway profile was present in Mongolian's gut which mainly distributed in amino acid metabolism, carbohydrate metabolism, energy metabolism, lipid metabolism, glycan biosynthesis and metabolism. We can attribute the specific signatures of Mongolian gut microbiome to their unique genotype, dietary habits and living environment.
authors.affiliation: Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of P. R. China, Department of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot 010018, China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Liu
authors.affiliation: Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of P. R. China, Department of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot 010018, China.
authors.forename: Jiachao
authors.initials: J
authors.lastname: Zhang
authors.affiliation: RealBio Genomic Institute, Shanghai 200050, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Wu
authors.affiliation: RealBio Genomic Institute, Shanghai 200050, China.
authors.forename: Shunfeng
authors.initials: S
authors.lastname: Cai
authors.affiliation: Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of P. R. China, Department of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot 010018, China.
authors.forename: Weiqiang
authors.initials: W
authors.lastname: Huang
authors.affiliation: RealBio Genomic Institute, Shanghai 200050, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.affiliation: Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of P. R. China, Department of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot 010018, China.
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Xi
authors.affiliation: RealBio Genomic Institute, Shanghai 200050, China.
authors.forename: Zebin
authors.initials: Z
authors.lastname: Liang
authors.affiliation: Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of P. R. China, Department of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot 010018, China.
authors.forename: Qiangchuan
authors.initials: Q
authors.lastname: Hou
authors.affiliation: RealBio Genomic Institute, Shanghai 200050, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhou
authors.affiliation: State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University, Hangzhou 310003, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Qin
authors.affiliation: Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of P. R. China, Department of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot 010018, China.
authors.forename: Heping
authors.initials: H
authors.lastname: Zhang
mesh_terms: D039903:Actinobacteria / Q000235:genetics / Q000502:physiology; D000328:Adult; D044466:Asian People; D001644:Bifidobacterium / Q000235:genetics / Q000502:physiology; D002087:Butyrates / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000382:microbiology; D005247:Feeding Behavior; D000069196:Gastrointestinal Microbiome / Q000235:genetics / Q000502:physiology*; D006801:Humans; D054892:Metagenome; D008986:Mongolia
chemical_list: D002087:Butyrates