title: Fasting plasma glucose levels and coronary artery calcification in subjects with impaired fasting glucose.
abstract: BACKGROUND
  Prediabetes is associated with an increased risk of cardiovascular disease (CVD). While the association of impaired glucose tolerance with CVD has been shown in many studies, the relationship between impaired fasting glucose (IFG) and CVD remains unclear.
  
  
  OBJECTIVE
  The purpose of this study was to compare the coronary artery calcium (CAC) scores of participants with normal fasting glucose versus those with IFG, according to fasting plasma glucose (FPG) levels, and to assess whether differences in CAC scores were independent of important confounders.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Health Promotion Center of the University Hospital (Gyeonggi-do, South Korea), during the period 2010-2014.
  
  
  METHODS
  Participants were enrolled from the general population who visited for a medical check-up. CAC was assessed in asymptomatic individuals by multidetector computed tomography. Anthropometric parameters and metabolic profiles were also recorded. Subjects were divided into four fasting glucose groups. Participants with a history of CVD or diabetes mellitus were excluded.
  
  
  METHODS
  Correlation between FPG and CAC scores, CAC score categories, and association between CAC score and FPG categories.
  
  
  RESULTS
  Of 1112 participants, 346 (34.2%) had a CAC score > 0. FPG values in the IFG patients were positively but weakly correlated with CAC scores (r=0.099, P=.001). The incidence of CAC differed according to FPG level (P < .001) and in Kruskal-Wallis test the mean CAC score differed by FPG group (P < .001). After adjustment for other factors in a multiple logistic regression analysis, those subjects with FPG >=110 mg/dL had a significantly higher risk of CAC than did subjects with normal fasting glucose (110.
authors.forename: Young-Mi
authors.initials: YM
authors.lastname: Eun
authors.affiliation: Sung-goo Kang MD, Department of Family Medicine,, St. Vincent's Hospital, Jungbudaero 93 Jidong,, Suwon 442723, South Korea, T: +82-10-249-8303, hippo94@naver.com, ORCID ID: http://orcid.org/0000-0003-4627-291X.
authors.forename: Sung-Goo
authors.initials: SG
authors.lastname: Kang
authors.forename: Sang-Wook
authors.initials: SW
authors.lastname: Song
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D005215:Fasting / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D012189:Retrospective Studies; D012307:Risk Factors; D061205:Vascular Calcification / Q000097:blood* / Q000000981:diagnostic imaging / Q000453:epidemiology*
chemical_list: D001786:Blood Glucose