title: Convergent Synthesis of the Dihydropyran Core Containing the C1-C15 Subunit of Sorangicin A Employing Gold(I)-Catalyzed Cyclization of an Allenic Alcohol.
abstract: A convergent route to the C1-C15 subunit of sorangicin A is disclosed. The key steps include carbon-carbon bond formation using an α-chloro sulfide, regioselective hydrozirconation of an internal alkyne for the preparation of a trisubstituted iodoalkene, allene formation using the Myers-Movassaghi protocol, stereoselective reduction of allylic and propargylic ketones using Noyori's catalyst, and gold(I)-catalyzed cyclization of a β-hydroxy allene to construct the dihydropyran ring.
authors.affiliation: Natural Product Chemistry Division, Indian Institute of Chemical Technology , Hyderabad 500007, India.
authors.forename: Sadagopan
authors.initials: S
authors.lastname: Raghavan
authors.affiliation: Natural Product Chemistry Division, Indian Institute of Chemical Technology , Hyderabad 500007, India.
authors.forename: Satyanarayana
authors.initials: S
authors.lastname: Nyalata