title: Technical feasibility and tissue reaction after silicone-covered biodegradable magnesium stent insertion in the oesophagus: a primary study in vitro and in vivo.
abstract: OBJECTIVE
  Determine the feasibility of and tissue response to biodegradable magnesium-silicone stent insertion into the oesophagus of rabbits.
  
  
  METHODS
  Mechanical compression-recovery and degradation behaviours of the stents were investigated in vitro. Thirty rabbits were randomly divided into a magnesium-silicone stent group (n = 15) that received stent insertion into the lower 1/3 of the oesophagus under fluoroscopic guidance and a control group (n = 15). Oesophagography was performed at 1, 2 and 4 weeks. Five rabbits in each group were euthanized at each time point for histological examination.
  
  
  RESULTS
  Magnesium-silicone stents showed good flexibility and elasticity, and degraded more slowly than bare stents at pH 4.0 and 7.4. All stent insertions were well tolerated. The oesophageal diameters at 1, 2 and 4 weeks were 9.7 ± 0.7, 9.6 ± 0.8 and 9.6 ± 0.5 mm, respectively (vs. 9.2 ± 0.8 mm before intervention; P > 0.05). Stent migration occurred in six rabbits (one at 1 week, one at 2 and four at 4). Microscopy demonstrated dilation of the oesophageal wall within 1 week of insertion. Oesophageal injury and collagen deposition following stent insertion were similar to control (P > 0.05).
  
  
  CONCLUSIONS
  Oesophageal magnesium-silicone stent insertion was feasible and provided reliable support for 2 weeks without causing oesophageal injury or collagen deposition.
  
  
  CONCLUSIONS
  • Mg stent provided apparently adequate radial force and silicone membrane reduced magnesium biodegradation • Stent insertion provided good support for at least 2 weeks before biodegradation • Stenting effectively resulted in oesophageal wall remodelling, without demonstrable injury.
authors.affiliation: Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600, Yi Shan Road, Shanghai, 200233, China.
authors.forename: Yue-Qi
authors.initials: YQ
authors.lastname: Zhu
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, 708 Renmin Rd, Suzhou, Jiangsu, 215006, People's Republic of China.|Nanotechnology Engineering, University of Waterloo, Waterloo, Ontario, N2L3G1, Canada.
authors.forename: Laura
authors.initials: L
authors.lastname: Edmonds
authors.affiliation: Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600, Yi Shan Road, Shanghai, 200233, China.
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Wei
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, 708 Renmin Rd, Suzhou, Jiangsu, 215006, People's Republic of China.
authors.forename: Rei-La
authors.initials: RL
authors.lastname: Zheng
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, 708 Renmin Rd, Suzhou, Jiangsu, 215006, People's Republic of China.
authors.forename: Ruo-Yu
authors.initials: RY
authors.lastname: Cheng
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, 708 Renmin Rd, Suzhou, Jiangsu, 215006, People's Republic of China. wgcui80@hotmail.com.
authors.forename: Wen-Guo
authors.initials: WG
authors.lastname: Cui
authors.affiliation: Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600, Yi Shan Road, Shanghai, 200233, China. chengyingshengradio@hotmail.com.
authors.forename: Ying-Sheng
authors.initials: YS
authors.lastname: Cheng
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D004947:Esophagus / Q000601:surgery*; D005240:Feasibility Studies; D005260:Female; D005548:Foreign-Body Migration; D006801:Humans; D066298:In Vitro Techniques; D008274:Magnesium / Q000494:pharmacology*; D008297:Male; D011474:Prosthesis Design; D011817:Rabbits; D011897:Random Allocation; D012826:Silicone Elastomers / Q000494:pharmacology*; D015607:Stents
chemical_list: D012826:Silicone Elastomers; D008274:Magnesium
keywords: Biodegradation; Interventional radiology; Magnesium; Oesophagus; Stent