title: The SaeRS Two-Component System of  Staphylococcus aureus.
abstract: In the Gram-positive pathogenic bacterium Staphylococcus aureus, the SaeRS twocomponent system (TCS) plays a major role in controlling the production of over 20 virulence factors including hemolysins, leukocidins, superantigens, surface proteins, and proteases. The SaeRS TCS is composed of the sensor histidine kinase SaeS, response regulator SaeR, and two auxiliary proteins SaeP and SaeQ. Since its discovery in 1994, the sae locus has been studied extensively, and its contributions to staphylococcal virulence and pathogenesis have been well documented and understood; however, the molecular mechanism by which the SaeRS TCS receives and processes cognate signals is not. In this article, therefore, we review the literature focusing on the signaling mechanism and its interaction with other global regulators.
authors.affiliation: Department of Laboratory Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China. qq2005011@163.com.
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Microbiology and Immunology, Indiana University School of Medicine-Northwest, Gary, IN 46408, USA. wonyeo@iu.edu.
authors.forename: Won-Sik
authors.initials: WS
authors.lastname: Yeo
authors.affiliation: Department of Microbiology and Immunology, Indiana University School of Medicine-Northwest, Gary, IN 46408, USA. tbae@iun.edu.
authors.forename: Taeok
authors.initials: T
authors.lastname: Bae
keywords: Staphylococcus aureus;  Bacterial histidine  kinase;  Two‐component system;  Virulence factors