title: Accelerated Intermittent Theta Burst Stimulation for Suicide Risk in Therapy-Resistant Depressed Patients: A Randomized, Sham-Controlled Trial.
abstract: Objectives:We aimed to examine the effects and safety of accelerated intermittent Theta Burst Stimulation (iTBS) on suicide risk in a group of treatment-resistant unipolar depressed patients, using an extensive suicide assessment scale.Methods:In 50 therapy-resistant, antidepressant-free depressed patients, an intensive protocol of accelerated iTBS was applied over the left dorsolateral prefrontal cortex (DLPFC) in a randomized, sham-controlled crossover design. Patients received 20 iTBS sessions over 4 days. Suicide risk was assessed using the Beck Scale of Suicide ideation (BSI).Results:The iTBS protocol was safe and well tolerated. We observed a significant decrease of the BSI score over time, unrelated to active or sham stimulation and unrelated to depression-response. No worsening of suicidal ideation was observed. The effects of accelerated iTBS on mood and depression severity are reported in Duprat et al. (2016). The decrease in suicide risk lasted up to 1 month after baseline, even in depression non-responders.Conclusions:This accelerated iTBS protocol was safe. The observed significant decrease in suicide risk was unrelated to active or sham stimulation and unrelated to depression response. Further sham-controlled research in suicidal depressed patients is necessary. (Clinicaltrials.gov identifier: NCT01832805).
authors.affiliation: Department of Psychiatry and Institute for Neuroscience, University Hospital Ghent Ghent, Belgium.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Desmyter
authors.affiliation: Department of Psychiatry and Medical Psychology, Ghent University Ghent, Belgium.
authors.forename: Romain
authors.initials: R
authors.lastname: Duprat
authors.affiliation: Department of Psychiatry and Medical Psychology, Ghent University Ghent, Belgium.
authors.forename: Chris
authors.initials: C
authors.lastname: Baeken
authors.affiliation: Department of Psychiatry and Medical Psychology, Ghent University Ghent, Belgium.
authors.forename: Sara
authors.initials: S
authors.lastname: Van Autreve
authors.affiliation: Department of Psychiatry and Medical Psychology, Ghent University Ghent, Belgium.
authors.forename: Kurt
authors.initials: K
authors.lastname: Audenaert
authors.affiliation: Unit for Suicide Research, Department of Psychiatry and Medical Psychology, Ghent University Ghent, Belgium.
authors.forename: Kees
authors.initials: K
authors.lastname: van Heeringen
keywords: depression; repetitive transcranial magnetic stimulation; suicidal ideation; suicide; therapy-resistant depression; theta burst stimulation