title: Feasibility and tolerability of whole-body, low-intensity vibration and its effects on muscle function and bone in patients with dystrophinopathies: a pilot study.
abstract: Dystrophinopathies are X-linked muscle degenerative disorders that result in progressive muscle weakness complicated by bone loss. This study's goal was to evaluate feasibility and tolerability of whole-body, low-intensity vibration (WBLIV) and its potential effects on muscle and bone in patients with Duchenne or Becker muscular dystrophy.
  
  
  
  This 12-month pilot study included 5 patients (age 5.9-21.7 years) who used a low-intensity Marodyne LivMD plate vibrating at 30-90 Hz for 10 min/day for the first 6 months. Timed motor function tests, myometry, and peripheral quantitative computed tomography were performed at baseline and at 6 and 12 months.
  
  
  
  Motor function and lower extremity muscle strength remained either unchanged or improved during the intervention phase, followed by deterioration after WBLIV discontinuation. Indices of bone density and geometry remained stable in the tibia.
  
  
  
  WBLIV was well tolerated and appeared to have a stabilizing effect on lower extremity muscle function and bone measures. Muscle Nerve 55: 875-883, 2017.
authors.affiliation: Division of Pediatric Endocrinology, University of Minnesota Masonic Children's Hospital, 2450 Riverside Avenue, Minneapolis, Minnesota, 55454, USA.|Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Anna
authors.initials: A
authors.lastname: Petryk
authors.affiliation: Division of Pediatric Endocrinology and Metabolism, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
authors.forename: Lynda E
authors.initials: LE
authors.lastname: Polgreen
authors.affiliation: Department of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Molly
authors.initials: M
authors.lastname: Grames
authors.affiliation: Department of Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Dawn A
authors.initials: DA
authors.lastname: Lowe
authors.affiliation: Division of Biostatistics, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: James S
authors.initials: JS
authors.lastname: Hodges
authors.affiliation: Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.|Department of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Karachunski
mesh_terms: D000293:Adolescent; D000328:Adult; D015519:Bone Density / Q000502:physiology*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D053580:Muscle Strength / Q000502:physiology*; D053581:Muscle Strength Dynamometer; D018482:Muscle, Skeletal / Q000473:pathology / Q000503:physiopathology*; D009136:Muscular Dystrophies / Q000150:complications* / Q000473:pathology* / Q000628:therapy; D010865:Pilot Projects; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D014732:Vibration; D016138:Walking; D055815:Young Adult
keywords: Becker muscular dystrophy; Duchenne muscular dystrophy; myometry; pQCT; timed function test; vibration