title: Role of the Histamine H4-Receptor in Bronchial Asthma.
abstract: Histamine is a pro-inflammatory mediator with a prominent role in allergic diseases. Antagonists at the histamine receptor subtype 1 are central in anti-allergic therapies, with the exception of allergic asthma, where they are clinically without effect. The latest identified histamine receptor subtype 4, which is expressed mainly in hematopoietic cells, now provides a reasonable target for new therapeutic strategies inhibiting histamine function. The pathophysiology of allergy, esp. allergic asthma, and in its context the effects of antagonists at the histamine receptor subtype 4 in preclinical and clinical settings are discussed in this chapter.
authors.affiliation: Hannover Medical School, Hannover, Germany. Neumann.Detlef@mh-hannover.de.
authors.forename: Detlef
authors.initials: D
authors.lastname: Neumann
mesh_terms: D000818:Animals; D001249:Asthma / Q000188:drug therapy / Q000378:metabolism*; D006633:Histamine Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy / Q000378:metabolism; D011968:Receptors, Histamine / Q000378:metabolism*
chemical_list: D006633:Histamine Antagonists; D011968:Receptors, Histamine
keywords: Allergy; Asthma; Dendritic cell; Sensitization; T cell