title: Molecular Targets and Emerging Therapeutic Options for Uterine Leiomyosarcoma.
abstract: Uterine leiomyosarcoma (uLMS) is an aggressive malignancy characterized by its early metastasis, high rates of recurrence, and poor prognosis. Multiple obstacles complicate the clinical management of uLMS. These include the fact that most uLMS are typically identified only after a woman has undergone hysterectomy or myomectomy, the limited efficacy of adjuvant therapy for early stage disease, and the poor response of metastatic disease to current treatments. Here, we discuss recent insights into the molecular basis of uLMS and discuss emerging options for its clinical management. Particular attention is given to the biologic basis of these strategies with the goal of understanding the rationale motivating their use.
authors.affiliation: Department of Obstetrics & Gynecology, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Heather
authors.initials: H
authors.lastname: Miller
authors.affiliation: College of Pharmacy, University of Houston, Houston, TX 77030, USA.
authors.forename: Chiemeka
authors.initials: C
authors.lastname: Ike
authors.affiliation: College of Pharmacy, University of Houston, Houston, TX 77030, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Parma
authors.affiliation: Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Ramya P
authors.initials: RP
authors.lastname: Masand
authors.affiliation: Department of Obstetrics & Gynecology, Baylor College of Medicine, Houston, TX 77030, USA; College of Pharmacy, University of Houston, Houston, TX 77030, USA.
authors.forename: Claire M
authors.initials: CM
authors.lastname: Mach
authors.affiliation: Department of Obstetrics & Gynecology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Matthew L
authors.identifier: 0000-0002-2081-4672
authors.initials: ML
authors.lastname: Anderson