title: Expression and prognostic significance of CTBP2 in human gliomas.
abstract: Deregulated expression of C-terminal-binding protein 2 (CTBP2) has been observed previously in a number of tumors, such as hepatocellular carcinoma and prostatic cancer, in the colorectal cancer SW480 cell line and in the human embryonic kidney 293 cell line. In the present study, western blot analysis and immunohistochemistry were performed to investigate whether gliomas exhibit deregulated CTBP2 expression. Kaplan-Meier survival analyses were performed to evaluate the associations between CTBP2 expression, clinicopathological data and patient survival in glioma patients. The results revealed that CTBP2 expression was significantly upregulated in high grade glioma tissues compared with that in low grade glioma and normal brain tissues. Furthermore, increased CTBP2 expression in gliomas was significantly associated with a higher World Health Organization (WHO) tumor grade (P<0.005) and poorer disease-specific survival (P<0.005). In conclusion, these results suggest that CTBP2 may act as an intrinsic regulator of progression in glioma cells and thus may serve as an important prognostic factor for the disease.
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, The Affiliated Hospital of Qingdao Medical College, Qingdao University, Qingdao, Shandong 266003, P.R. China.
authors.forename: Shusheng
authors.initials: S
authors.lastname: Che
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China.
authors.forename: Gang
authors.initials: G
authors.lastname: Cai
authors.affiliation: Department of Neurosurgery, The Affiliated Hospital of Qingdao Medical College, Qingdao University, Qingdao, Shandong 266003, P.R. China.
authors.forename: Yuchao
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China.
authors.forename: Jialei
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
keywords: CTBP2; clinical significance; expression; gliomas