title: Physical activity as a vital sign in patients with bipolar disorder.
abstract: The most significant contributor to premature mortality in patients with bipolar disorder is preventable cardiovascular diseases. This study investigated if the Physical Activity Vital Sign (PAVS) assessment (two questions which clarify if a person meets the recommended 150min of physical activity per week) can identify patients with bipolar disorder at higher risk of cardio-metabolic abnormalities. Clinical differences between those who adhere and those who did not adhere to the physical activity guidelines were investigated using an ANCOVA controlling for age and gender. Sixty-five (29♂) in- and outpatients with bipolar disorder (age=45.1±9.8years) completed the PAVS-questions, underwent full-fasting metabolic screening, and performed a six-minute walk test (6MWT). Those patients not meeting the physical activity recommendations had a higher body mass index, performed worse on the 6MWT and were at a significantly higher risk for cardio-metabolic diseases. Relative risks ranged from 1.33 for having dyslipidemia to 5.33 for hyperglycemia. The current data offer the first evidence that the PAVS assessment might be a useful vital sign in the routine assessment of in- and outpatients with bipolar disorder.
authors.affiliation: KU Leuven - University of Leuven Department of Rehabilitation Sciences, Leuven, Belgium; KU Leuven - University of Leuven, University Psychiatric Center KU Leuven, Kortenberg-Leuven, Belgium. Electronic address: davy.vancampfort@uc-kortenberg.be.
authors.forename: Davy
authors.initials: D
authors.lastname: Vancampfort
authors.affiliation: KU Leuven - University of Leuven Department of Rehabilitation Sciences, Leuven, Belgium.
authors.forename: Michel
authors.initials: M
authors.lastname: Probst
authors.affiliation: KU Leuven - University of Leuven, University Psychiatric Center KU Leuven, Kortenberg-Leuven, Belgium.
authors.forename: Sabine
authors.initials: S
authors.lastname: Wyckaert
authors.affiliation: KU Leuven - University of Leuven, University Psychiatric Center KU Leuven, Kortenberg-Leuven, Belgium.
authors.forename: Marc
authors.initials: M
authors.lastname: De Hert
authors.affiliation: Physiotherapy Department, South London and Maudsley NHS FoundationTrust, Denmark Hill, London SE5 8AZ, United Kingdom; Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience King's College London, De Crespigny Park, London SE5 8AF, United Kingdom.
authors.forename: Brendon
authors.initials: B
authors.lastname: Stubbs
authors.affiliation: School of Psychiatry, University of New South Wales, Sydney, Australia.
authors.forename: Simon
authors.initials: S
authors.lastname: Rosenbaum
authors.affiliation: KU Leuven - University of Leuven, University Psychiatric Center KU Leuven, Kortenberg-Leuven, Belgium.
authors.forename: Pascal
authors.initials: P
authors.lastname: Sienaert
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000453:epidemiology; D015992:Body Mass Index; D015897:Comorbidity; D015444:Exercise / Q000523:psychology; D005080:Exercise Test; D005260:Female; D019983:Guideline Adherence; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology; D008875:Middle Aged
keywords: Bipolar disorder; Exercise; Hypertension; Metabolic syndrome; Obesity; Physical activity