title: A dual-response fluorescent probe for Zn2+and Al3+detection in aqueous media: pH-dependent selectivity and practical application.
abstract: A Schiff base-type fluorescent probe (1) consist of 2-hydroxynaphthaldehyde and glutamide moieties has been designed and synthesized for detection Zn2+and Al3+. The probe shows pH dependent dual-selectivity for Zn2+and Al3+in Tris-HCl buffer, viz. that can selectively recognized Zn2+at pH 7.4 and Al3+at pH 6.0, respectively. From Job's plots and MS data, the stoichiometric ratios of the probe with Zn2+and Al3+appeared to be 1:1 and 2:1, respectively. The probe can detect as low as 5.5 × 10-8M-1Zn2+and 1.27 × 10-7M-1Al3+, whereas respective association constants are 4.27 × 104M-1and 3.50 × 109M-1. Furthermore, it is also confirmed that the probe has good cell-permeability and could thus be used to selectively sense intracellular Zn2+and Al3+by bioimaging in different pH environment. Finally the probe has been used successfully for determination of the analytes in real drug samples.
authors.affiliation: Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules of the Ministry of Education, Department of Chemistry, Yanbian University, Yanji 133002, PR China.
authors.forename: Yunqiang
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules of the Ministry of Education, Department of Chemistry, Yanbian University, Yanji 133002, PR China.
authors.forename: Jinguo
authors.initials: J
authors.lastname: Sun
authors.affiliation: Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules of the Ministry of Education, Department of Chemistry, Yanbian University, Yanji 133002, PR China. Electronic address: zqcong@ybu.edu.cn.
authors.forename: Bingzhu
authors.initials: B
authors.lastname: Yin
mesh_terms: D000535:Aluminum / Q000032:analysis*; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D005456:Fluorescent Dyes / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D066244:Proton Magnetic Resonance Spectroscopy; D012545:Schiff Bases / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D014867:Water / Q000737:chemistry*; D015032:Zinc / Q000032:analysis*
chemical_list: D005456:Fluorescent Dyes; D012545:Schiff Bases; D014867:Water; D000535:Aluminum; D015032:Zinc
keywords: Al(3+); Bioimaging; Drug sample; Schiff base-type fluorescent probe; Zn(2+); pH dependent selectivity