title: Fecal biomarkers in inflammatory bowel disease.
abstract: Over the last two decades, knowledge on fecal biomarkers has substantially increased. Nowadays, these non-invasive markers of inflammation have significant clinical utility in the management of inflammatory bowel disease. Their use informs the decision to perform endoscopy before diagnosis is made right through to influencing therapeutic choices and the need for interval endoscopic assessment. In this review, the roles of two S100 proteins, calprotectin, and S100A12 are described along with that of lactoferrin, in the context of inflammatory bowel disease.
authors.affiliation: Department of Paediatrics, University of Otago (Christchurch), Christchurch, New Zealand.
authors.forename: Robert N
authors.initials: RN
authors.lastname: Lopez
authors.affiliation: School of Women's and Children's Health, University of New South Wales, Sydney, New South Wales, Australia.
authors.forename: Steven T
authors.initials: ST
authors.lastname: Leach
authors.affiliation: School of Women's and Children's Health, University of New South Wales, Sydney, New South Wales, Australia.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Lemberg
authors.affiliation: School of Women's and Children's Health, University of New South Wales, Sydney, New South Wales, Australia.
authors.forename: Gilles
authors.initials: G
authors.lastname: Duvoisin
authors.affiliation: Department of Medicine, University of Otago (Christchurch), Christchurch, New Zealand.
authors.forename: Richard B
authors.initials: RB
authors.lastname: Gearry
authors.affiliation: Department of Paediatrics, University of Otago (Christchurch), Christchurch, New Zealand.
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Day
mesh_terms: D015415:Biomarkers / Q000032:analysis; D005243:Feces / Q000737:chemistry*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis*; D039841:Leukocyte L1 Antigen Complex / Q000032:analysis*; D009418:S100 Proteins / Q000032:analysis*; D000067616:S100A12 Protein / Q000032:analysis*
chemical_list: D015415:Biomarkers; D039841:Leukocyte L1 Antigen Complex; D009418:S100 Proteins; C110294:S100A1 protein; D000067616:S100A12 Protein; C090441:S100A12 protein, human
keywords: fecal markers; inflammation; inflammatory bowel disease