title: Different etiologies and prognoses of optic neuritis in demyelinating diseases.
abstract: We compared the clinical features of optic neuritis (ON) that are frequently observed in various central nervous system demyelinating diseases, including multiple sclerosis (MS), anti-aquaporin 4 (AQP4) antibody- and anti-myelin oligodendrocyte glycoprotein (MOG) autoantibody-related diseases. Almost all the AQP4-ON patients were female, whereas half of the MOG-ON patients were male. The ON-onset age was younger in MS-ON and was older in AQP4-ON. The ON-lesion detected using optic MRI in the acute phase was longer in MOG-ON and showed severe swelling and twisting. The worst visual acuity was similar between the diseases; however, the final visual acuity was significantly worse in AQP4-ON.
authors.affiliation: Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address: t-akaishi@med.tohoku.ac.jp.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Akaishi
authors.affiliation: Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address: nakashima@med.tohoku.ac.jp.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Nakashima
authors.affiliation: Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address: takeshita.oph@me.com.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Takeshita
authors.affiliation: Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address: k-kaneko@med.tohoku.ac.jp.
authors.forename: Kimihiko
authors.initials: K
authors.lastname: Kaneko
authors.affiliation: Department of Diagnostic Radiology, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address: mugi844@gmail.com.
authors.forename: Shunji
authors.initials: S
authors.lastname: Mugikura
authors.affiliation: Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address: douglas.sato@med.tohoku.ac.jp.
authors.forename: Douglas Kazutoshi
authors.initials: DK
authors.lastname: Sato
authors.affiliation: Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Neurology, Yonezawa National Hospital, Yonezawa, Japan. Electronic address: t-toshiyuki@mta.biglobe.ne.jp.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Takahashi
authors.affiliation: Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address: ntoru@oph.med.tohoku.ac.jp.
authors.forename: Toru
authors.initials: T
authors.lastname: Nakazawa
authors.affiliation: Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address: aokim@med.tohoku.ac.jp.
authors.forename: Masashi
authors.initials: M
authors.lastname: Aoki
authors.affiliation: Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Multiple Sclerosis Therapeutics, Fukushima Medical University, Fukushima, Japan. Electronic address: fujikazu@med.tohoku.ac.jp.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Fujihara
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D051401:Aquaporin 4 / Q000097:blood; D003430:Cross-Sectional Studies; D003711:Demyelinating Diseases / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009902:Optic Neuritis / Q000097:blood / Q000000981:diagnostic imaging* / Q000209:etiology*; D011379:Prognosis; D012189:Retrospective Studies; D014786:Vision Disorders / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology; D055815:Young Adult
chemical_list: D051401:Aquaporin 4
keywords: Anti-MOG autoantibody; Multiple sclerosis; Neuromyelitis optica spectrum disorder; Optic MRI; Optic neuritis; Visual prognosis