title: Helicobacter pyloriinfection and colorectal carcinoma risk: A meta-analysis.
abstract: OBJECTIVE
  Helicobacter pylori infection and colorectal cancer risk are not clear. We perform this meta-analysis to further evaluate the association between H. pylori infection and colorectal cancer susceptibility.
  
  
  METHODS
  The databases of CNKI, Wanfang, PubMed, Medline, EMBASE, and HighWire Press were electronic searched by two reviewers independently. The case-control study or cohort study about H. pylori infection and colorectal cancer risk were included in this meta-analysis. The association between H. pylori infection and colorectal cancer risk was evaluated by odds ratio (OR) and corresponding 95% confidence interval (95% CI).
  
  
  RESULTS
  Fourteen case-control studies related to H. pylori infection and colorectal cancer risk were eventually include in this meta-analysis. The pooled results showed that H. pylori infection slight increase the risk of developing colorectal carcinoma (OR = 1.33, 95% CI: 1.01-1.77, P = 0.05). Moreover, Begg's funnel plot demonstrated no significant publication bias.
  
  
  CONCLUSIONS
  Colorectal carcinoma is associated with H. pylori infection. However, for significant heterogeneity across the studies, this results should be further confirmed by large sample size cohort study.
authors.affiliation: Department of Chinese and Western Medicine, Tianjin Fourth Center Hospital (Tianjin Medical University Fourth Center Clinical College), Tianjin 300140, P.R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Hematology-Oncology, Tianjin Fourth Center Hospital (Tianjin Medical University Fourth Center Clinical College), Tianjin 300140, P.R. China.
authors.forename: Xuli
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology, Tianjin Fourth Center Hospital (Tianjin Medical University Fourth Center Clinical College), Tianjin 300140, P.R. China.
authors.forename: Yanrong
authors.initials: Y
authors.lastname: Wang
mesh_terms: D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D016481:Helicobacter Infections / Q000150:complications* / Q000382:microbiology; D016480:Helicobacter pylori; D006801:Humans; D017594:Publication Bias; D012306:Risk