title: Preoperative Body Mass Index May Determine the Prognosis of Advanced Gastric Cancer.
abstract: Radical gastrectomy followed by adjuvant chemotherapy for advanced gastric cancer causes serious nutritional impairment. Our study evaluated the clinical impact of body mass index (BMI) on the long-term outcomes of advanced gastric cancer (stage II and III). We analyzed 211 cases of stage II and III gastric cancer between January 2005 and December 2010 at Chung-Ang University Hospital, Seoul, Korea. Patients were divided into four groups according to BMI: underweight, normal, overweight, and obese. In addition, we divided patients into two groups: BMI-High (BMI ≥ 23 kg/m2) vs. BMI-Low (BMI < 23 kg/m2). We assessed age, sex, tumor location, lymph node (LN) involvement, operation method, initial cancer stage, recurrence, and survival between the two groups. There was significant difference in overall survival (OS) between the underweight group and the other groups (P = 0.005). The survival of the BMI-High group was better than that of the BMI-Low group. The rate of cancer-related death in the BMI-High group was significantly lower than that in the BMI-Low group (cancer-related death: BMI-Low 27% vs. BMI-High 12.6%, P = 0.022). Our findings suggest that preoperative BMI may have an influence on the long-term outcomes of advanced gastric cancer after radical surgery and chemotherapy.
authors.affiliation: a Department of Internal Medicine , Chung-Ang University Hospital, Chung-Ang University College of Medicine , Seoul , Korea.
authors.forename: Dong Hwan
authors.initials: DH
authors.lastname: Jun
authors.affiliation: a Department of Internal Medicine , Chung-Ang University Hospital, Chung-Ang University College of Medicine , Seoul , Korea.
authors.forename: Beom Jin
authors.initials: BJ
authors.lastname: Kim
authors.affiliation: a Department of Internal Medicine , Chung-Ang University Hospital, Chung-Ang University College of Medicine , Seoul , Korea.
authors.forename: Ji Hoon
authors.initials: JH
authors.lastname: Park
authors.affiliation: a Department of Internal Medicine , Chung-Ang University Hospital, Chung-Ang University College of Medicine , Seoul , Korea.
authors.forename: Jae G
authors.initials: JG
authors.lastname: Kim
authors.affiliation: b Department of Surgery , Chung-Ang University Hospital, Chung-Ang University College of Medicine , Seoul , Korea.
authors.forename: Kyong-Choun
authors.initials: KC
authors.lastname: Chi
authors.affiliation: b Department of Surgery , Chung-Ang University Hospital, Chung-Ang University College of Medicine , Seoul , Korea.
authors.forename: Joong-Min
authors.initials: JM
authors.lastname: Park
authors.affiliation: c Department of Pathology , Chung-Ang University Hospital, Chung-Ang University College of Medicine , Seoul , Korea.
authors.forename: Mi Kyung
authors.initials: MK
authors.lastname: Kim
authors.affiliation: d Department of Anesthesiology and Pain Medicine , Chung-Ang University Hospital, Chung-Ang University College of Medicine , Seoul , Korea.
authors.forename: Hyun
authors.initials: H
authors.lastname: Kang
mesh_terms: D000368:Aged; D015992:Body Mass Index; D018572:Disease-Free Survival; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D009765:Obesity / Q000150:complications; D050177:Overweight / Q000150:complications; D057234:Preoperative Period; D013274:Stomach Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome