title: Association of the Common Catalase Gene Polymorphism rs1001179 With Glycated Hemoglobin and Plasma Lipids in Hyperlipidemic Patients.
abstract: Catalase represents perhaps the most effective antioxidant defense in the body under conditions of increased oxidative stress, and rs1001179 (CAT-262C >T) is its most extensively studied gene polymorphism. Using an established PCR-RFLP method for genotyping, we examined the association of rs1001179 with glycated hemoglobin (HbA1c) and plasma lipids using univariate analyses with age, sex, body mass index (BMI), smoking, and alcohol abuse as covariates, in a group of dyslipidemic patients from northern Greece. Our results suggest that the TT genotype is a risk factor for increased HbA1c and plasma triglycerides, and that this association is modulated by the BMI and/or age of the patients.
authors.affiliation: 1st Laboratory of Pharmacology, Faculty of Medicine, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece. goulas@med.auth.gr.
authors.forename: Antonis
authors.identifier: http://orcid.org/0000-0002-6189-594X
authors.initials: A
authors.lastname: Goulas
authors.affiliation: 1st Propedeutic Department of Internal Medicine, AHEPA Hospital, Faculty of Medicine, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Agapakis
authors.affiliation: 1st Laboratory of Pharmacology, Faculty of Medicine, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.
authors.forename: Athanassios
authors.initials: A
authors.lastname: Apostolidis
authors.affiliation: 1st Laboratory of Pharmacology, Faculty of Medicine, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.
authors.forename: Dimitra
authors.initials: D
authors.lastname: Gouda
authors.affiliation: 3rd Department of Internal Medicine, Papageorgiou Hospital, Faculty of Medicine, Aristotle University of Thessaloniki, 54629, Thessaloniki, Greece.
authors.forename: Sotirios
authors.initials: S
authors.lastname: Anastassiadis
authors.affiliation: 3rd Department of Internal Medicine, Papageorgiou Hospital, Faculty of Medicine, Aristotle University of Thessaloniki, 54629, Thessaloniki, Greece.
authors.forename: Christina
authors.initials: C
authors.lastname: Trakatelli
authors.affiliation: 1st Propedeutic Department of Internal Medicine, AHEPA Hospital, Faculty of Medicine, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.
authors.forename: Christos
authors.initials: C
authors.lastname: Savopoulos
authors.affiliation: 1st Propedeutic Department of Internal Medicine, AHEPA Hospital, Faculty of Medicine, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.
authors.forename: Apostolos I
authors.initials: AI
authors.lastname: Hatzitolios
mesh_terms: D000367:Age Factors; D015992:Body Mass Index; D002374:Catalase / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006442:Glycated Hemoglobin / Q000235:genetics*; D006115:Greece; D006801:Humans; D006949:Hyperlipidemias / Q000201:enzymology* / Q000235:genetics* / Q000503:physiopathology; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D002374:Catalase; D006442:Glycated Hemoglobin; D008055:Lipids; C577219:CAT protein, human
keywords: Catalase; Gene polymorphism; Glycated hemoglobin; Plasma lipids; rs1001179