title: Human ESC-Derived Interneurons Improve Major Consequences of Spinal Cord Injury.
abstract: Beyond impaired motor and sensory function, neuropathic pain and loss of bladder control caused by spinal cord injuries (SCIs) can severely affect quality of life. In this issue of Cell Stem Cell, Fandel et al. (2016) show that transplanted human ESC-derived cells biased to produce inhibitory interneurons significantly improve pain and bladder function in rodent SCI models.
authors.affiliation: Department of Neurological Surgery and Goodman Campbell Brain and Spine, Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indianapolis, IN 46202, USA. Electronic address: ablesch@iupui.edu.
authors.forename: Armin
authors.initials: A
authors.lastname: Blesch
mesh_terms: D000066449:Human Embryonic Stem Cells / Q000166:cytology*; D006801:Humans; D007395:Interneurons / Q000166:cytology* / Q000637:transplantation; D013119:Spinal Cord Injuries / Q000473:pathology* / Q000628:therapy; D057170:Translational Research, Biomedical