title: [Concordance between hospital prescriptions and recommendations in the treatment of mania].
abstract: OBJECTIVE
  There are differences between recommendations and practice in the pharmacological treatment of acute mania.
  
  
  OBJECTIVE
  The objective was to assess conformity of the anti-manic prescription between national recommendations (Haute Autorité de santé [French health authority, HAS] and "résumé des caractéristiques du produit" [product characteristics, RCP]) and clinical practice.
  
  
  METHODS
  We observed the drug prescriptions of in-patients for a manic episode. The main outcome measure was the concordance rate with the recommendations of the drugs prescriptions at the 48th hour. The secondary outcome repeated the same process with the hospital discharge statement of switches, associations, the presence of symptomatic and antidepressant treatments.
  
  
  RESULTS
  Sixty-six episodes were included, 40 patients (60%) had a prescription complies with RCP recommendations H48 and 46 patients (70%) to HAS. These rates fall at hospital discharge.
  
  
  CONCLUSIONS
  Off-label prescriptions, drug combinations and choices of not listed molecules are the most common reasons for non-conformity.
authors.affiliation: Centre d'évaluation et de traitement des troubles de l'humeur complexes, CAPPA Jacques-Prévert, Hôtel-Dieu, CHU de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France. Electronic address: edouard.laforgue@chu-nantes.fr.
authors.forename: Edouard-Jules
authors.initials: EJ
authors.lastname: Laforgue
authors.affiliation: Centre d'évaluation et de traitement des troubles de l'humeur complexes, CAPPA Jacques-Prévert, Hôtel-Dieu, CHU de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France.
authors.forename: Samuel
authors.initials: S
authors.lastname: Bulteau
authors.affiliation: Service universitaire d'addictologie, hôpital Saint-Jacques, CHU de Nantes, 44093 Nantes, France; EA 4275 SPHERE « bioStatistics, Pharmacoepidemiology and Human sciEnces REsearch », faculté de médecine et pharmacie, université de Nantes, 44093 Nantes, France.
authors.forename: Jennyfer
authors.initials: J
authors.lastname: Cholet
authors.affiliation: EA 4275 SPHERE « bioStatistics, Pharmacoepidemiology and Human sciEnces REsearch », faculté de médecine et pharmacie, université de Nantes, 44093 Nantes, France; Service de pharmacologie clinique, institut de biologie, CHU de Nantes, 9, quai Moncousu, 44093 Nantes, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Victorri-Vigneau
authors.affiliation: Centre d'évaluation et de traitement des troubles de l'humeur complexes, CAPPA Jacques-Prévert, Hôtel-Dieu, CHU de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Guitteny
authors.affiliation: Service d'information médicale, CHU de Nantes, immeuble Deurbroucq, 44093 Nantes, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Mauduit
authors.affiliation: Centre d'évaluation et de traitement des troubles de l'humeur complexes, CAPPA Jacques-Prévert, Hôtel-Dieu, CHU de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France; Service d'information médicale, CHU de Nantes, immeuble Deurbroucq, 44093 Nantes, France.
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Vanelle
authors.affiliation: Centre d'évaluation et de traitement des troubles de l'humeur complexes, CAPPA Jacques-Prévert, Hôtel-Dieu, CHU de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France; EA 4275 SPHERE « bioStatistics, Pharmacoepidemiology and Human sciEnces REsearch », faculté de médecine et pharmacie, université de Nantes, 44093 Nantes, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Sauvaget
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy*; D011307:Drug Prescriptions / Q000706:statistics & numerical data; D005260:Female; D005602:France; D019983:Guideline Adherence; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D014150:Antipsychotic Agents
keywords: Bipolar disorder; Drug treatment; Good practice guide; Guide de bonnes pratiques; Pharmacoepidemiology; Pharmacoépidémiologie; Psychotropes; Psychotropic; Traitements médicamenteux; Trouble bipolaire