title: Laccase-mediated formation of mesoporous silica nanoparticle based redox stimuli-responsive hybrid nanogels as a multifunctional nanotheranostic agent.
abstract: In this work, we designed a new hybrid nanogel with redox responsive polymer gel shells and mesoporous silica nanoparticles (MSNs) cores via laccase-mediated radical polymerization. The successful coating of the responsive gel shells on the MSNs was confirmed by the morphology and increased diameters of the particles as determined by transmission electron microscopy (TEM) and dynamic light scattering (DLS). As observed by scanning transmission electron microscopy (STEM) and energy dispersive X-ray spectroscopy (EDS), the presence of the element S around the MSNs further confirmed the formation of the gel shell. When loaded with doxorubicin (DOX), these hybrid nanogels had a significantly higher cumulative DOX release in a reductive environment than that found under physiological conditions. The MSNs with mesoporous channels were loaded with perfluorohexane (PFH) for ultrasound imaging, which was enhanced by the presence of the elastic gel shells.
authors.affiliation: School of Chemical Science and Engineering, Tongji University, Shanghai 200092, China. 15174@tongji.edu.cn wangqg66@tongji.edu.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Qiao
authors.affiliation: School of Chemical Science and Engineering, Tongji University, Shanghai 200092, China. 15174@tongji.edu.cn wangqg66@tongji.edu.cn.
authors.forename: Xia
authors.initials: X
authors.lastname: Wang
authors.affiliation: School of Chemical Science and Engineering, Tongji University, Shanghai 200092, China. 15174@tongji.edu.cn wangqg66@tongji.edu.cn.
authors.forename: Yawei
authors.initials: Y
authors.lastname: Gao
authors.affiliation: School of Chemical Science and Engineering, Tongji University, Shanghai 200092, China. 15174@tongji.edu.cn wangqg66@tongji.edu.cn.
authors.forename: Qingcong
authors.initials: Q
authors.lastname: Wei
authors.affiliation: School of Chemical Science and Engineering, Tongji University, Shanghai 200092, China. 15174@tongji.edu.cn wangqg66@tongji.edu.cn.
authors.forename: Wen
authors.initials: W
authors.lastname: Hu
authors.affiliation: Department of Ultrasound in Medicine Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Medical Ultrasound Shanghai Tenth People's Hospital of Tongji University, Shanghai 200072, China.
authors.forename: Pei
authors.initials: P
authors.lastname: Li
authors.affiliation: School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
authors.forename: Rongrong
authors.initials: R
authors.lastname: Zhu
authors.affiliation: School of Chemical Science and Engineering, Tongji University, Shanghai 200092, China. 15174@tongji.edu.cn wangqg66@tongji.edu.cn.
authors.forename: Qigang
authors.identifier: http://orcid.org/0000-0002-4026-3337
authors.initials: Q
authors.lastname: Wang