title: Commensal or pathogen - a challenge to fulfil Koch's Postulates.
abstract: 1. Infectious diseases have a large impact on poultry health and economics. Elucidating the pathogenesis of a certain disease is crucial to implement control strategies. 2. Multiplication of a pathogen and its characterisation in vitro are basic requirements to perform experimental studies. However, passaging of the pathogen in vitro can influence the pathogenicity, a process targeted for live vaccine development, but limits the reproduction of clinical signs. 3. Numerous factors can influence the outcome of experimental infections with some importance on the pathogen, application route and host as exemplarily outlined for Histomonas meleagridis, Gallibacterium anatis and fowl aviadenoviruses (FAdVs). 4. In future, more comprehensive and detailed settings are needed to obtain as much information as possible from animal experiments. Processing of samples with modern diagnostic tools provides the option to closely monitor the host-pathogen interaction.
authors.affiliation: a Clinic for Poultry and Fish Medicine, Department for Farm Animals and Veterinary Public Health , University of Veterinary Medicine , Vienna , Austria.
authors.forename: M
authors.initials: M
authors.lastname: Hess
mesh_terms: D000257:Adenoviridae Infections / Q000266:history / Q000662:veterinary; D000818:Animals; D000259:Aviadenovirus / Q000145:classification; D002645:Chickens; D004739:England; D025681:Fowl adenovirus A; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D054884:Host-Pathogen Interactions; D015661:Pasteurellaceae / Q000145:classification; D016871:Pasteurellaceae Infections / Q000266:history / Q000382:microbiology / Q000662:veterinary; D011201:Poultry Diseases / Q000266:history / Q000382:microbiology* / Q000469:parasitology; D011529:Protozoan Infections, Animal / Q000266:history / Q000469:parasitology; D013559:Symbiosis