title: Hotspots of MLV integration in the hematopoietic tumor genome.
abstract: Extensive research has been performed regarding the integration sites of murine leukemia retrovirus (MLV) for the identification of proto-oncogenes. To date, the overlap of mutations within specific oligonucleotides across different tumor genomes has been regarded as a rare event; however, a recent study of MLV integration into the oncogene Zfp521 suggested the existence of a hotspot oligonucleotide for MLV integration. In the current review, we discuss the hotspots of MLV integration into several genes: c-Myc, Stat5a and N-myc, as well as ZFP521, as examined in tumor genomes. From this, MLV integration convergence within specific oligonucleotides is not necessarily a rare event. This short review aims to promote re-consideration of MLV integration within the tumor genome, which involves both well-known and potentially newly identified and novel mechanisms and specifications.
authors.affiliation: Department of Pathology, Kyoto University, Graduate School of Medicine, Sakyo-ku, Kyoto, Japan.|Center for Anatomical, Pathologic and Forensic Medical Research, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tsuruyama
authors.affiliation: Department of Pathology, Kyoto University, Graduate School of Medicine, Sakyo-ku, Kyoto, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hiratsuka
authors.affiliation: Center for Anatomical, Pathologic and Forensic Medical Research, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Yamada
mesh_terms: D015894:Genome, Human; D019337:Hematologic Neoplasms / Q000235:genetics*; D006801:Humans; D009052:Leukemia Virus, Murine / Q000235:genetics*; D016662:Virus Integration / Q000235:genetics*