title: Changing epidemiology of oral squamous cell carcinoma of the tongue: A global study.
abstract: There are reports about the changing epidemiology of tongue squamous cell carcinoma (SCC), with recent reports indicating an increasing incidence in young women.
  
  
  
  Data on incident cases of tongue SCC were collected from cancer registries worldwide.
  
  
  
  Data from a total of 22 cancer registries and 89,212 incident cases of tongue SCC worldwide were included. Most areas experienced an incidence increase ranging from 0.4% to 3.3% per year. There was a significant difference in the incidence increase between sexes in 11 of the 22 registries. In 14 of the 22 registries studied, the increase in incidence of tongue SCC was higher in the group of subjects <45 years old than those ≥45 years old.
  
  
  
  This study suggests a general but not universal increase in the incidence of tongue SCC worldwide. In some regions of the world, we observed a shifting trend toward women and/or younger patients. © 2016 Wiley Periodicals, Inc. Head Neck 39: 297-304, 2017.
authors.affiliation: Singhealth/Duke-NUS Head and Neck Centre, Singapore.
authors.forename: Jia Hui
authors.initials: JH
authors.lastname: Ng
authors.affiliation: Singhealth/Duke-NUS Head and Neck Centre, Singapore.
authors.forename: N Gopalakrishna
authors.initials: NG
authors.lastname: Iyer
authors.affiliation: Division of Biodevices and Diagnostics, Institute of Bioengineering and Nanotechnology.|Department of Medical Oncology, National Cancer Centre Singapore, Singapore.
authors.forename: Min-Han
authors.initials: MH
authors.lastname: Tan
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
authors.forename: Gustaf
authors.initials: G
authors.lastname: Edgren
mesh_terms: D000328:Adult; D017677:Age Distribution; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D014943:Global Health; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D038622:Internationality; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000453:epidemiology; D015995:Prevalence; D011379:Prognosis; D012042:Registries; D018570:Risk Assessment; D018426:SEER Program; D017678:Sex Distribution; D000077195:Squamous Cell Carcinoma of Head and Neck; D014062:Tongue Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D055815:Young Adult
keywords: carcinoma; epidemiology; incidence; registries; squamous cell; tongue neoplasms