title: Synthesis of Coumestrol and Aureol.
abstract: A total synthesis of coumestrol (1) and aureol (2) is described. The Perkin condensation of 2-bromo-4-hydroxylphenylacetic acid (6) and o-hydroxybenzaldehydes (7) gave the corresponding 2'-bromo-3-arylcoumarins (9). A copper-catalyzed consecutive hydroxylation and aerobic oxidative coupling of 9 under microwave conditions facilitated the total synthesis of 1 and 2, respectively, with spectroscopic data highly similar to those of natural products.
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou, 510006, People's Republic of China.|Zhongshan WanYuan New Drug R&D Co., Ltd. , Zhongshan City, 528451, People's Republic of China.
authors.forename: Jianfei
authors.initials: J
authors.lastname: Sheng
authors.affiliation: Guangzhou Institute of Chemistry, Chinese Academy of Sciences , Guangzhou, 510650, People's Republic of China.|Zhongshan WanYuan New Drug R&D Co., Ltd. , Zhongshan City, 528451, People's Republic of China.
authors.forename: Tianlong
authors.initials: T
authors.lastname: Xu
authors.affiliation: Guangzhou Institute of Chemistry, Chinese Academy of Sciences , Guangzhou, 510650, People's Republic of China.|Zhongshan WanYuan New Drug R&D Co., Ltd. , Zhongshan City, 528451, People's Republic of China.
authors.forename: Ensheng
authors.initials: E
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou, 510006, People's Republic of China.|Zhongshan WanYuan New Drug R&D Co., Ltd. , Zhongshan City, 528451, People's Republic of China.|Guangdong Provincial Key Laboratory of Brain Function and Disease, Sun Yat-sen University , Guangzhou, 510080, People's Republic of China.
authors.forename: Xuejing
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou, 510006, People's Republic of China.|Zhongshan WanYuan New Drug R&D Co., Ltd. , Zhongshan City, 528451, People's Republic of China.
authors.forename: Wentao
authors.initials: W
authors.lastname: Wei
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou, 510006, People's Republic of China.|Zhongshan WanYuan New Drug R&D Co., Ltd. , Zhongshan City, 528451, People's Republic of China.|Guangdong Provincial Key Laboratory of Brain Function and Disease, Sun Yat-sen University , Guangzhou, 510080, People's Republic of China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zou
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry; D003374:Coumarins / Q000737:chemistry; D003375:Coumestrol / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D003374:Coumarins; D012717:Sesquiterpenes; C455540:aureol; D003300:Copper; C505898:coumestan; D003375:Coumestrol