title: Association between the -174 G/C polymorphism of the interleukin-6 gene and myocardial infarction risk: a meta-analysis.
abstract: Numerous studies have evaluated the association between the -174 G/C polymorphism in the interleukin-6 gene (IL6) and myocardial infarction (MI) risk. However, the results from the published studies are inconclusive. The aim of this meta-analysis was to determine whether the IL6 -174 G/C polymorphism is associated with MI risk. A meta-analysis based on nine case-control studies was performed to address this issue. No significant associations between IL6 -174 G/C polymorphism and MI risk were observed in any of the genetic models (CC vs GG: OR = 1.18, 95%CI = 0.92-1.52; CG vs GG: OR = 1.09, 95%CI = 0.93-1.27; dominant model: OR = 1.11, 95%CI = 0.94-1.31; recessive model: OR = 1.10, 95%CI = 0.91-1.33). Furthermore, the subgroup analysis by ethnicity did not reveal a significant association between the IL6 -174 G/C polymorphism and susceptibility to MI in Caucasians. In conclusion, the results indicate that the IL6 -174 G/C polymorphism does not contribute to MI risk.
authors.affiliation: Department of Pharmacy, Central Hospital of Zhumadian, Zhumadian, China jingzhou07@126.com.
authors.forename: J
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Clinical Medicine Department of Traditional Chinese Medicine, Henan University of Traditional Chinese, Zhengzhou, China.
authors.forename: J
authors.initials: J
authors.lastname: Feng
authors.affiliation: Interventional Ultrasound Department of the Chinese PLA General Hospital, Beijing, China.
authors.forename: X
authors.initials: X
authors.lastname: Li
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D005006:Ethnicity; D020022:Genetic Predisposition to Disease; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics* / Q000378:metabolism; D009203:Myocardial Infarction / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D044465:White People
chemical_list: D015850:Interleukin-6