title: Synthesis and Antimicrobial Activity of Some New Quinoxaline Derivatives.
abstract: 2-Chloro-3-methylquinoxaline was selected as a nucleus around which various molecular transformations were performed to obtain new compounds expected to possess optimized antimicrobial activity. As very little work regarding attachment of ether linkages replacing chlorine at C-2 has been reported, it was thought worthwhile to synthesize various quinoxaline derivatives by replacing the C₂ chlorine with an ether linkage attached to a benzene ring possessing an aldehyde or a free amino group which can be further reacted with aromatic amines and aromatic aldehydes, respectively, to yield new Schiff bases containing quinoxaline moieties. Thus the compounds 4-(2-methylquinoxalinyloxy) benzaldehyde (4), 2-[4-(substituted-benziminomethyl)-phenoxy]-3-methyl quinoxalines 5a-e, 4-(2-methyl-quinoxaline-3-yloxy)benzamine (6) and 4-(2-methylquinoxalin-3-yloxy)-N-substituted benzylidine benzamines 7a-e were synthesized and tested for their antimicrobial activity. The structures of the compounds were confirmed on the basis of their elemental and spectral data.
authors.affiliation: Department of Pharmaceutical Chemistry, College of Pharmacy, Institute of Foreign Trade and Management, Moradabad - 244001, India. dcp_singh@yahoo.com.
authors.forename: Dharmchand Prasad
authors.initials: DP
authors.lastname: Singh
authors.affiliation: Department of Pharmaceutical Chemistry, College of Pharmacy, Institute of Foreign Trade and Management, Moradabad - 244001, India. sanjaydeivedi@yahoo.co.in.
authors.forename: Sanjay Kumar
authors.initials: SK
authors.lastname: Deivedi
authors.affiliation: Department of Pharmaceutical Chemistry, College of Pharmacy, Institute of Foreign Trade and Management, Moradabad - 244001, India. sriaz_hashim@yahoo.com.
authors.forename: Syed Riaz
authors.initials: SR
authors.lastname: Hashim
authors.affiliation: School of Pharmaceutical Sciences, Shobhit University, Meerut, India. drrgsinghal@rediffmail.com.
authors.forename: Ram Gopal
authors.initials: RG
authors.lastname: Singhal
keywords: antimicrobial activity; benzaldehyde; benzamine; quinoxalines