title: A concise gram-scale synthesis of ht-13-A via a rhodium-catalyzed intramolecular C-H activation reaction.
abstract: The enantioselective total synthesis of the 3,4-fused indole alkaloid ht-13-A has been achieved. The synthesis features a zinc-mediated propargylation, a rhodium-catalyzed intramolecular C-H activation reaction, and a methylamine-mediated cyclization. This concise and efficient synthetic approach can be applied for the gram-scale synthesis of ht-13-A.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China. yxjia@bjmu.edu.cn.
authors.forename: Pengyu
authors.initials: P
authors.lastname: Tao
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China. yxjia@bjmu.edu.cn.
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China. yxjia@bjmu.edu.cn and State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
authors.forename: Yanxing
authors.initials: Y
authors.lastname: Jia