title: Multiple-factor analysis of the first radioactive iodine therapy in post-operative patients with differentiated thyroid cancer for achieving a disease-free status.
abstract: 131I treatment is an important management method for patients with differentiated thyroid cancer (DTC). Unsuccessful131I ablation drastically affects the prognosis of the patients. This study aimed to analyze potential predictive factors influencing the achievement of a disease-free status following the first131I therapy. This retrospective review included 315 DTC patients, and multiple factors were analyzed. Tumor size, pathological tumor stage, lymph node (LN) metastasis, distant metastasis, American Thyroid Association recommended risks, pre-ablation thyroglobulin (Tg), and thyroid stimulating hormone (TSH) displayed significant differences between unsuccessful and successful group. Cutoff values of Tg and TSH to predict a successful outcome were 3.525 ng/mL and 99.700 uIU/ml by receiver operating characteristic curves analysis. Binary logistic regression analysis showed that tumor stage T3 or T4, LN metastasis to N1b station, intermediate and high risks, pre-ablation Tg ≥ 3.525 ng/ml and TSH <99.700 μIU/mL were significantly associated with unsuccessful outcomes. Logistic regression equation for achieving a disease-free status could be rendered as: y (successful treatment) = -0.270-0.503 X1(LN metastasis) -0.236 X2(Tg) + 0.015 X3(TSH). This study demonstrated LN metastasis, pre-ablation Tg and TSH were the most powerful predictors for achieving a disease-free status by the first131I therapy.
authors.affiliation: Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, P. R. China.
authors.forename: Na
authors.initials: N
authors.lastname: Liu
authors.affiliation: Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, P. R. China.
authors.forename: Zhaowei
authors.initials: Z
authors.lastname: Meng
authors.affiliation: Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, P. R. China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Jia
authors.affiliation: Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, P. R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Tan
authors.affiliation: Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, P. R. China.
authors.forename: Guizhi
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.affiliation: Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, P. R. China.
authors.forename: Renfei
authors.initials: R
authors.lastname: Wang
authors.affiliation: Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, P. R. China.
authors.forename: Xue
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, P. R. China.
authors.forename: Tianpeng
authors.initials: T
authors.lastname: Hu
authors.affiliation: Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, P. R. China.
authors.forename: Arun
authors.initials: A
authors.lastname: Upadhyaya
authors.affiliation: Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, P. R. China.
authors.forename: Pingping
authors.initials: P
authors.lastname: Zhou
authors.affiliation: Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, P. R. China.
authors.forename: Sen
authors.initials: S
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D013995:Time; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007457:Iodine Radioisotopes