title: Self-organization in development, regeneration and organoids.
abstract: Self-organization of cells is a fundamental design principle in biology, yet the inherent non-linearity of self-organizing systems often poses significant challenges in deciphering the underlying mechanisms. Here, we discuss recent progress in this respect, focusing on examples from development, regeneration and organoid differentiation. Together, these three paradigms emphasize the active material properties of tissues that result from the functional coupling between individual cells as active units. Further, we discuss the challenge of obtaining reproducible outcomes on the basis of self-organizing systems, which development and regeneration, but not the current organoid culture protocols, achieve.
authors.affiliation: Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany; Max Planck Institute for the Physics of Complex Systems, Nöthnitzer Str. 38, 01187 Dresden, Germany.
authors.forename: Steffen
authors.initials: S
authors.lastname: Werner
authors.affiliation: Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.
authors.forename: Hanh Thi-Kim
authors.initials: HT
authors.lastname: Vu
authors.affiliation: Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany. Electronic address: rink@mpi-cbg.de.
authors.forename: Jochen C
authors.initials: JC
authors.lastname: Rink
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D047108:Embryonic Development; D053263:Gene Regulatory Networks; D006801:Humans; D009940:Organoids / Q000166:cytology*; D012038:Regeneration