title: Multi-targeting Andrographolide and its Natural Analogs as Potential Therapeutic Agents.
abstract: Andrographis paniculata (A. paniculata) is a medicinal plant used in the Indian and Chinese traditional medicinal systems for its various beneficial properties of therapeutics. This is due to the presence of a diterpene lactone called 'andrographolide'. Several biological activities like antiinflammatory, antitumour, anti-hyperglycaemic, anti-fertility, antiviral, cardio protective and hepatoprotective properties are attributed to andrographolide and its natural analogs. The studies have shown that not only this diterpene lactone (andrographolide), but also other related terpenoid analogs from A. paniculata could be exploited for disease prevention due to their structural similarity with diverse pharmacological activities. Several scientific groups are trying to unveil the underlying mechanisms involved in these biological actions brough aout by andrographolide and its analogs. This review aims at giving an overview on the therapeutical and/or pharmacological activities of andrographolide and its derivatives and also exemplify the underlying mechanisms involved.
authors.forename: V
authors.initials: V
authors.lastname: Kishore
authors.affiliation: Department of Biochemistry, Institute of Science, GITAM University, Visakhapatnam, Andhra Pradesh, India.
authors.forename: Nagendra Sastry
authors.initials: NS
authors.lastname: Yarla
authors.forename: Anupam
authors.initials: A
authors.lastname: Bishayee
authors.forename: Swathi
authors.initials: S
authors.lastname: Putta
authors.forename: Ramarao
authors.initials: R
authors.lastname: Malla
authors.forename: Nageswara Rao Reddy
authors.initials: NR
authors.lastname: Neelapu
authors.forename: Surekha
authors.initials: S
authors.lastname: Challa
authors.forename: Subhasish
authors.initials: S
authors.lastname: Das
authors.forename: Yallappa
authors.initials: Y
authors.lastname: Shiralgi
authors.forename: Gurumurthy
authors.initials: G
authors.lastname: Hegde
authors.affiliation: Department of Research, School of Chemical and Biotechnology (SCBT), SASTRA University, Thirumalaisamudram, Thanjavur-613401, India.
authors.forename: Bhadrapura Lakkappa
authors.initials: BL
authors.lastname: Dhananjaya
mesh_terms: D035685:Andrographis / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D008968:Molecular Conformation; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents; D001688:Biological Products; D004224:Diterpenes; D007004:Hypoglycemic Agents; C030419:andrographolide
keywords: Andrographis paniculata; Andrographolide; Pharmacological activities; Terpenoid