title: A Comprehensive Review on the Biological and Pharmacological Activities of Rhodanine Based Compounds for Research and Development of Drugs.
abstract: At present, diseases resulting from various reasons have been causing deadly fears to humans and previously incogitable losses to health. Meanwhile, the patient compliance has been weakening because of drug resistance and serious drug adverse effects. There is therefore an urgent need for the development of novel structural agents. Rhodanine derivatives have exhibited wide biological activities, as well as significant industrial applications, which suggests that rhodanine heterocycle represents a key structural motif in heterocyclic chemistry and occupies a prominent position in drug discovery. Here, we review some deadly defects of clinical medicines to the therapy of diseases and important advances on rhodanine derivatives in drug researches (e.g. as anti-diabetic, anti-viral, antiinflammatory, anti-microbial, anti-tumor agents and inhibitors for Alzheimer Disease), indicating that rhodanine heterocycle could be used as a significant pharmacophore to develop novel pharmacological active molecules. It is believed that the review is of importance for new ideas in the development of and rational designs of rhodanine-based drugs.
authors.affiliation: Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, 310014, China.
authors.forename: Jiachun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Lab of Molecular Immunology, Virus Inspection Department, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, 310051, China.
authors.forename: Yanling
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, College of Pharmacy, Yanbian University, Yanji, Jilin Province 133002, China.
authors.forename: Huri
authors.initials: H
authors.lastname: Piao
authors.affiliation: Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, 310014, China.
authors.forename: Xiaoyin
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, 310014, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, 310014, China.
authors.forename: Yanli
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, 310014, China.
authors.forename: Minrui
authors.initials: M
authors.lastname: Liu
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy; D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D003920:Diabetes Mellitus / Q000188:drug therapy; D015195:Drug Design; D006801:Humans; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D009369:Neoplasms / Q000188:drug therapy*; D012236:Rhodanine / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D007004:Hypoglycemic Agents; D012236:Rhodanine
keywords: Adverse effect; bioactivity; drug resistance; pharmacological active molecule; pharmacophore; rhodanine.