title: Role of ABCB1 C1236T, G2677T, and C3435T genetic polymorphisms in the development of acute leukemia in a Chinese population.
abstract: We carried out a case-control study to examine the relationship between the ATP-binding cassette subfamily B member 1 (ABCB1) gene polymorphisms C1236T, G2677T, and C3435T and risk of acute leukemia in a Chinese population. Between May 2013 and April 2015, we recruited 164 acute leukemia patients and 285 healthy controls, and determined polymorphism genotypes by polymerase chain reaction-restriction fragment length polymorphism. Using unconditional logistic regression analysis, we observed that in comparison to the wild-type sequence, the TT genotype [odds ratio (OR) = 2.15, 95% confidence interval (CI) = 1.12-4.10; P = 0.01] and the T allele (OR = 1.39, 95%CI = 1.05-1.86; P = 0.02) of ABCB1 G2677T were associated with acute leukemia susceptibility. The TT genotype (OR = 2.03, 95%CI = 1.11- 3.69; P = 0.01) and the T allele (OR = 1.39, 95%CI = 1.05-1.85; P = 0.02) of the C3435T polymorphism also increased acute leukemia risk compared to the wild-type form. However, no significant relationship was established between the ABCB1 C1236T variant and this disease. Our results suggest that the ABCB1 G2677T and C3435T sequence variations may affect susceptibility to acute leukemia.
authors.affiliation: Department of Hematology, Qilu Hospital, Shandong University, Jinan, China ruifengrf18@163.com.|Department of Hematology, Yantai Yuhuangding Hospital, Yantai, China ruifengrf18@163.com.
authors.forename: R
authors.initials: R
authors.lastname: Feng
authors.affiliation: Department of Pharmacy, Yantai Yuhuangding Hospital, Yantai, China.
authors.forename: H X
authors.initials: HX
authors.lastname: Zhang
authors.affiliation: Department of Hematology, Qilu Hospital, Shandong University, Jinan, China.|Department of Hematology, Jining No. 1 People's Hospital, Jining, China.
authors.forename: H G
authors.initials: HG
authors.lastname: Zhang
authors.affiliation: Department of Clinical Laboratory, Jining No. 1 People's Hospital, Jining, China.
authors.forename: C F
authors.initials: CF
authors.lastname: Zhang
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics; D000208:Acute Disease; D000328:Adult; D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D007938:Leukemia / Q000235:genetics* / Q000473:pathology; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B