title: Current Immunotherapies for Sarcoma: Clinical Trials and Rationale.
abstract: Sarcoma tumors are rare and heterogeneous, yet they possess many characteristics that may facilitate immunotherapeutic responses. Both active strategies including vaccines and passive strategies involving cellular adoptive immunotherapy have been applied clinically. Results of these clinical trials indicate a distinct benefit for select patients. The recent breakthrough of immunologic checkpoint inhibition is being rapidly introduced to a variety of tumor types including sarcoma. It is anticipated that these emerging immunotherapies will exhibit clinical efficacy for a variety of sarcomas. The increasing ability to tailor immunologic therapies to sarcoma patients will undoubtedly generate further enthusiasm and clinical research for this treatment modality.
authors.affiliation: Department of Medical Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
authors.forename: Demytra
authors.initials: D
authors.lastname: Mitsis
authors.affiliation: Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
authors.forename: Valerie
authors.initials: V
authors.lastname: Francescutti
authors.affiliation: Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA; Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
authors.forename: Joseph
authors.identifier: 0000-0002-3689-2843
authors.initials: J
authors.lastname: Skitzki