title: Poly(butylene adipate-co-terephthalate) scaffolds: processing, structural characteristics and cellular responses.
abstract: The aliphatic-aromatic copolyester, poly(butylene adipate-co-terephthalate) (PBAT) combines good mechanical and thermal properties with biodegradation ability. However, until now, researches in its potential medical use remain limited. Only in a few studies blends of PBAT with routinely used biocompatible polymers had been prepared and investigated regarding tissue engineering applications. Therefore, in this study, we decided to determine processability of neat PBAT as a scaffold material for bone tissue by using different fabrication methods i.e. solvent evaporation, electrospinning, solvent casting-particulate leaching (SCPL) and melt molding-particulate leaching. The results of physicochemical characterizations and cell culture studies with MC3T3-E1 preosteoblasts confirmed that neat PBAT has favorable characteristics for bone tissue engineering, however, fabrication method strongly affects the cellular responses. Regarding to the characterizations and cell cultures, PBAT scaffolds produced by SCPL and electrospinning are proposed to be used for bone tissue engineering.
authors.affiliation: a Department of Chemical Engineering , Hacettepe University , Ankara , Turkey.
authors.forename: Aysu
authors.initials: A
authors.lastname: Arslan
authors.affiliation: b Department of Nanotechnology and Nanomedicine , Hacettepe University , Ankara , Turkey.
authors.forename: Soner
authors.initials: S
authors.lastname: Çakmak
authors.affiliation: c Department of Bioengineering , Hacettepe University , Ankara , Turkey.
authors.forename: Alper
authors.initials: A
authors.lastname: Cengiz
authors.affiliation: a Department of Chemical Engineering , Hacettepe University , Ankara , Turkey.|b Department of Nanotechnology and Nanomedicine , Hacettepe University , Ankara , Turkey.|c Department of Bioengineering , Hacettepe University , Ankara , Turkey.
authors.forename: Menemşe
authors.initials: M
authors.lastname: Gümüşderelioğlu
keywords: Poly(butylene adipate-co-terephthalate); bone tissue engineering; electrospinning; melt molding-particulate leaching; scaffold; solvent casting-particulate leaching