title: Progress toward reaction monitoring at variable temperatures: a new stopped-flow NMR probe design.
abstract: A stopped-flow NMR probe is described that enables fast flow rates, short transfer times, and equilibration of the reactant magnetization and temperature prior to reaction. The capabilities of the probe are demonstrated by monitoring the polymerization of lactide as catalyzed by the air-sensitive catalyst 1,3-dimesitylimidazol-2-ylidene (IMes) over the temperature range of -30 to 40 °C. The incorporation of stopped-flow capabilities into an NMR probe permits the rich information content of NMR to be accessed during the first few seconds of a fast reaction. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Department of Chemistry, University of Wisconsin, Madison, WI, United States.
authors.forename: Anna L
authors.identifier: http://orcid.org/0000-0001-5026-2883
authors.initials: AL
authors.lastname: Dunn
authors.affiliation: Department of Chemistry, University of Wisconsin, Madison, WI, United States.
authors.forename: Clark R
authors.initials: CR
authors.lastname: Landis
mesh_terms: D002384:Catalysis; D007093:Imidazoles; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D011091:Polyesters / Q000138:chemical synthesis; D013696:Temperature
chemical_list: C504863:1,3-dimesitylimidazolin-2-ylidene; D007093:Imidazoles; D011091:Polyesters; C033616:poly(lactide)
keywords: kinetics; reaction monitoring; stopped-flow NMR