title: More Challenges From Ebola: Infection of the Central Nervous System.
abstract: Cases of relapsed Ebola virus disease involving symptoms in the central nervous system are reminiscent of our past observations with some nonhuman primates (NHPs) that survived acute Ebola virus infection. We document our findings in detail here and suggest that this phenomenon can be further investigated in NHPs.
authors.affiliation: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada Department of Medical Microbiology.
authors.forename: Gary
authors.initials: G
authors.lastname: Wong
authors.affiliation: Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada Department of Medical Microbiology.
authors.forename: Xiangguo
authors.initials: X
authors.lastname: Qiu
authors.affiliation: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, China.
authors.forename: Yuhai
authors.initials: Y
authors.lastname: Bi
authors.affiliation: Department of Pandemic and Epidemic Diseases, World Health Organization, Geneva, Switzerland.
authors.forename: Pierre
authors.initials: P
authors.lastname: Formenty
authors.affiliation: Médecins Sans Frontières, Operational Center of Brussels, Belgium.
authors.forename: Armand
authors.initials: A
authors.lastname: Sprecher
authors.affiliation: Department of Infection, Royal Free London NHS Foundation Trust, London, United Kingdom.
authors.forename: Michael
authors.initials: M
authors.lastname: Jacobs
authors.affiliation: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences Office of the Director General, Chinese Center for Disease Control and Prevention, Beijing Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, China.
authors.forename: George F
authors.initials: GF
authors.lastname: Gao
authors.affiliation: Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada Department of Medical Microbiology Department of Immunology, University of Manitoba, Winnipeg, Canada Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia.
authors.forename: Gary
authors.initials: G
authors.lastname: Kobinger
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000821:virology*; D029043:Ebolavirus / Q000472:pathogenicity*; D019142:Hemorrhagic Fever, Ebola / Q000821:virology*; D006801:Humans; D012008:Recurrence
keywords: Ebola virus; central nervous system; nonhuman primates; relapse; outbreak