title: Angio-oedema associated with colistin.
abstract: A 50-year-old woman known to have type 1 diabetes mellitus presented with a rare case of angio-oedema associated with colistin use. The angio-oedema was temporally associated with the use and discontinuation of colistin with the reasonable exclusion of important differential diagnoses. Pseudoallergy may be a probable underlying mechanism. However, we cannot exclude the possibility of hereditary angio-oedema type 2 or 3, or that her concomitant medications (particularly enalapril) and her renal impairment contributed to the risk and severity of her angio-oedema.
authors.affiliation: Division of Clinical Pharmacology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa. aaabulfathi@sun.ac.za.
authors.forename: A A
authors.initials: AA
authors.lastname: Abulfathi
authors.forename: T
authors.initials: T
authors.lastname: Greyling
authors.forename: M
authors.initials: M
authors.lastname: Makiwane
authors.forename: M
authors.initials: M
authors.lastname: Esser
authors.forename: E
authors.initials: E
authors.lastname: Decloedt
mesh_terms: D040981:Acinetobacter baumannii / Q000302:isolation & purification; D000799:Angioedema / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D018926:Anti-Allergic Agents / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects; D003091:Colistin / Q000008:administration & dosage / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage*; D008875:Middle Aged; D011398:Promethazine / Q000008:administration & dosage*; D018805:Sepsis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome; D014552:Urinary Tract Infections / Q000150:complications* / Q000382:microbiology; D028761:Withholding Treatment
chemical_list: D018926:Anti-Allergic Agents; D000900:Anti-Bacterial Agents; D011398:Promethazine; D006854:Hydrocortisone; D003091:Colistin