title: Control of Drug Diffusion Behavior of Xanthan and Locust Bean Gum Gel by Agar Gel.
abstract: Oral gel formulations are known as easy to administer drug products for patients who have problems taking drugs including those with conditions such as dysphagia. In addition, there are numerous commercially available oral gel products, most of which are immediate-release formulation that release their pharmaceutical ingredient content by diffusion. This study is focused on developing oral gel formulations that reduce the dosing frequency and dosage compared to the conventional types. This is with the aim of facilitating the use of gel formulations for producing pharmaceutical agents with different dose regimens, thereby enhancing patient convenience. Here, we used naturally derived high-molecular-weight agar (Ag), xanthan gum (Xa), and locust bean gum (Lo) as gel bases to prepare a variety of gel membranes, and evaluated the diffusion coefficient of the model substances. The result revealed that the Ag content in the Xa-Lo combination gel concentration-dependently increased the diffusion coefficient. Moreover, these findings were applied in an attempt to mask the taste of intensely bitter levofloxacin. The results indicated that the Xa-Lo combination gel exhibited a significantly superior masking effect to that of the Ag gel. This study demonstrates the feasibility of using oral gel formulations to modulate the controlled-release functionality of pharmaceutical agents.
authors.affiliation: Department of Research and Development, Ohkura Pharmaceutical Co., Ltd.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Hishikawa
authors.forename: Yukari
authors.initials: Y
authors.lastname: Kakino
authors.forename: Hoshi
authors.initials: H
authors.lastname: Tsukamoto
authors.forename: Kohei
authors.initials: K
authors.lastname: Tahara
authors.forename: Risako
authors.initials: R
authors.lastname: Onodera
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Takeuchi
mesh_terms: D000284:Administration, Oral; D000362:Agar / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004058:Diffusion; D065546:Drug Liberation; D005685:Galactans / Q000008:administration & dosage / Q000737:chemistry*; D005782:Gels / Q000008:administration & dosage / Q000737:chemistry*; D008351:Mannans / Q000008:administration & dosage / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry*; D053149:Plant Gums / Q000008:administration & dosage / Q000737:chemistry*; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage / Q000737:chemistry*; D012995:Solubility
chemical_list: D005685:Galactans; D005782:Gels; D008351:Mannans; D004364:Pharmaceutical Preparations; D053149:Plant Gums; D011135:Polysaccharides, Bacterial; D000362:Agar; C002563:xanthan gum; C017471:locust bean gum