title: δ and γ tocotrienols suppress human hepatocellular carcinoma cell proliferation via regulation of Ras-Raf-MEK-ERK pathway-associated upstream signaling.
abstract: Tocotrienol (T3) has recently gained increasing interest due to its anti-cancer effect. Here, we investigated the modulating effect of δ and γ T3 on the Ras-Raf-MEK-ERK oncogenic upstream signaling pathway in human hepatocellular carcinoma HepG2 cells. The results indicated that T3 regulated the upstream signaling cascades of this pathway.
authors.affiliation: Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Sciences, Tohoku University, Sendai, Japan. nkgw@m.tohoku.ac.jp.
authors.forename: Gregor Carpentero
authors.initials: GC
authors.lastname: Burdeos
authors.affiliation: Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Sciences, Tohoku University, Sendai, Japan. nkgw@m.tohoku.ac.jp.
authors.forename: Junya
authors.initials: J
authors.lastname: Ito
authors.affiliation: Faculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Eitsuka
authors.affiliation: Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Sciences, Tohoku University, Sendai, Japan. nkgw@m.tohoku.ac.jp.
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Nakagawa
authors.affiliation: Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Sciences, Tohoku University, Sendai, Japan. nkgw@m.tohoku.ac.jp.
authors.forename: Fumiko
authors.initials: F
authors.lastname: Kimura
authors.affiliation: Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Sciences, Tohoku University, Sendai, Japan. nkgw@m.tohoku.ac.jp and Food and Biotechnology Innovation Project, New Industry Creation Hatchery Center (NICHe), Tohoku University, Sendai, Japan.
authors.forename: Teruo
authors.initials: T
authors.lastname: Miyazawa
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects*; D002839:Chromans / Q000737:chemistry / Q000494:pharmacology*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000235:genetics / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D056945:Hep G2 Cells; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism; D020930:MAP Kinase Kinase Kinases / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D048490:raf Kinases / Q000235:genetics / Q000378:metabolism*; D018631:ras Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D002839:Chromans; D014810:Vitamin E; C082097:tocotrienol, delta; C013649:plastochromanol 8; D048490:raf Kinases; D048049:Extracellular Signal-Regulated MAP Kinases; D020930:MAP Kinase Kinase Kinases; D018631:ras Proteins