title: Features of chronic renal disease in children.
abstract: BACKGROUND
  chronic renal disease (CKD) is the inevitable outcome of many chronic diseases of the kidneys, which not all survive. The number of patients with chronic renal diseases is constantly growing. Aim to study the level osteocalcin and calcitonin and parathyroid hormone and immunological features in patients with chronic renal diseases. Materials and method The study involved 10 children with chronic renal failure at the age from 7 to 14 years in the initial stage - GFR 60-40 ml/min, creatinine blood increased to 180 μmol/l, and 20 healthy patients as a control group.
  
  
  RESULTS
  in the studies there was significant increase in the level of calcitonin , osteocalcin, parathyroid hormone in patients with chronic renal failure. In patients with chronic renal disease decreased indices of cellular and humoral immunity. In children with chronic renal disease significantly increased CIK and decreased the content of IFN-γ, FNO-α in comparison with the group of healthy children.
  
  
  CONCLUSIONS
  revealed that at all stages of CKD patients there is a change of level calcitonin, osteocalcin and parathyroid hormone. All patients with CKD, there was a reduction of humoral and cellular immunity.
authors.affiliation: Medical Institute of North -East Federal University named after M. K. Ammosov, Yakutsk, Russia.
authors.forename: Olga N
authors.initials: ON
authors.lastname: Ivanova
authors.affiliation: Medical Institute of North -East Federal University named after M. K. Ammosov, Yakutsk, Russia.
authors.forename: Natalia A
authors.initials: NA
authors.lastname: Savvina
authors.affiliation: Medical Institute of North -East Federal University named after M. K. Ammosov, Yakutsk, Russia.
authors.forename: Victoria E
authors.initials: VE
authors.lastname: Egorova
mesh_terms: D000293:Adolescent; D002116:Calcitonin / Q000097:blood*; D002648:Child; D003404:Creatinine / Q000097:blood; D006801:Humans; D007107:Immune System / Q000503:physiopathology*; D015675:Osteocalcin / Q000097:blood*; D010281:Parathyroid Hormone / Q000097:blood*; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000276:immunology / Q000503:physiopathology
chemical_list: D010281:Parathyroid Hormone; D015675:Osteocalcin; D002116:Calcitonin; D003404:Creatinine
keywords: calcitonin; chronic kidney disease; osteocalcin; parathormone; parathyroid hormone