title: Estimation of shear stress by using a myocardial bridge-mural coronary artery simulating device.
abstract: BACKGROUND
  This study was aimed at developing a myocardial bridge-mural coronary artery simulative device and analyzing the relationship between shear stress on the mural coronary artery and atherosclerosis.
  
  
  METHODS
  A myocardial bridge-mural coronary artery simulative device was used to simulate experiments in vitro. In the condition of maintaining any related parameters such as system temperature, average flow rate, and heart rate, we calculated and observed changes in proximal and distal mean values, and oscillatory value of shear stress on the mural coronary artery by regulating the compression level of the myocardial bridge to the mural coronary artery.
  
  
  RESULTS
  Under 0% compression, no significant differences were observed in distal and proximal mean values and oscillatory value of the shear stress on the mural coronary artery. With the increase in the degree of compression, the mean shear stress at the distal end was greater than that at the proximal end, but the oscillatory value of the shear stress at the proximal end was greater than that at the distal end.
  
  
  CONCLUSIONS
  The experimental results of this study indicate that myocardial bridge compression leads to abnormal hemodynamics at the proximal end of the mural coronary artery. This abnormal phenomenon is of great significance in the study of atherosclerosis hemodynamic pathogenesis, which has potential clinical value for pathological effects and treatments of myocardial bridge.
authors.forename: Hao
authors.initials: H
authors.lastname: Ding
authors.forename: Qian
authors.initials: Q
authors.lastname: Yang
authors.forename: Kun
authors.initials: K
authors.lastname: Shang
authors.forename: Hailian
authors.initials: H
authors.lastname: Lan
authors.forename: Jie
authors.initials: J
authors.lastname: Lv
authors.forename: Zhilin
authors.initials: Z
authors.lastname: Liu
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Lixing
authors.initials: L
authors.lastname: Sheng
authors.affiliation: Biomechanics and Medical Information Institute, Beijing University of Technology, Beijing, China. yjzeng@bjut.edu.cn.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Zeng
mesh_terms: D003324:Coronary Artery Disease / Q000503:physiopathology*; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000503:physiopathology*; D006353:Heart-Assist Devices; D006439:Hemodynamics; D006801:Humans; D008953:Models, Anatomic; D008955:Models, Cardiovascular; D054084:Myocardial Bridging / Q000503:physiopathology*; D011474:Prosthesis Design; D013314:Stress, Mechanical
keywords: hemodynamic; mural coronary artery; myocardial bridge; shear stress