title: Role of Soft-Tissue Heterogeneity in Computational Models of Deep Brain Stimulation.
abstract: Bioelectric field models of deep brain stimulation (DBS) are commonly utilized in research and industrial applications. However, the wide range of different representations used for the human head in these models may be responsible for substantial variance in the stimulation predictions.
  
  
  
  Determine the relative error of ignoring cerebral vasculature and soft-tissue heterogeneity outside of the brain in computational models of DBS.
  
  
  
  We used a detailed atlas of the human head, coupled to magnetic resonance imaging data, to construct a range of subthalamic DBS volume conductor models. We incrementally simplified the most detailed base model and quantified changes in the stimulation thresholds for direct activation of corticofugal axons.
  
  
  
  Ignoring cerebral vasculature altered predictions of stimulation thresholds by <10%, whereas ignoring soft-tissue heterogeneity outside of the brain altered predictions between -44 % and 174%.
  
  
  
  Heterogeneity in the soft tissues of the head, if unaccounted for, introduces a degree of uncertainty in predicting electrical stimulation of neural elements that is not negligible and thereby warrants consideration in future modeling studies.
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Bryan
authors.initials: B
authors.lastname: Howell
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA. Electronic address: ccm4@case.edu.
authors.forename: Cameron C
authors.initials: CC
authors.lastname: McIntyre
mesh_terms: D001369:Axons / Q000502:physiology; D001921:Brain / Q000502:physiology*; D003198:Computer Simulation; D046690:Deep Brain Stimulation / Q000379:methods*; D004558:Electric Stimulation; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008959:Models, Neurological; D020531:Subthalamic Nucleus / Q000502:physiology
keywords: Deep brain stimulation; Electric field; Heterogeneity; Soft tissues; Vasculature