title: Therapy resistant idiopathic scleredema: an underlying pathology not always present.
abstract: Scleredema is a rare connective tissue disorder of unknown pathogenesis. Three types of scleredema have been described, based on its association with postinfection, monoclonal gammopathy and diabetes mellitus. We report herein a case of scleredema which the diagnosis didn't get specified. The patient was followed regularly for 13 years and did not respond to various combinations of immunosuppressants and psoralen plus ultraviolet A therapy. Treatment of scleredema is quite difficult and of limited success. At present, there is no proved treatment for this disease.
authors.affiliation: Department of Internal Medicine, Division of Rheumatology, Ege University Faculty of Medicine, İzmir, Turkey.
authors.forename: Melike
authors.initials: M
authors.lastname: Kalfa
authors.affiliation: Department of Internal Medicine, Division of Rheumatology, Ege University Faculty of Medicine, İzmir, Turkey.
authors.forename: Hayriye
authors.initials: H
authors.lastname: Koçanaoğulları
authors.affiliation: Department of Internal Medicine, Division of Rheumatology, Ege University Faculty of Medicine, İzmir, Turkey.
authors.forename: Figen Yargucu
authors.initials: FY
authors.lastname: Zihni
authors.affiliation: Department of Internal Medicine, Division of Rheumatology, Ege University Faculty of Medicine, İzmir, Turkey.
authors.forename: Gonca
authors.initials: G
authors.lastname: Karabulut
authors.affiliation: Department of Internal Medicine, Division of Rheumatology, Ege University Faculty of Medicine, İzmir, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Emmungil
authors.affiliation: Department of Internal Medicine, Division of Rheumatology, Ege University Faculty of Medicine, İzmir, Turkey.
authors.forename: Vedat
authors.initials: V
authors.lastname: İnal
keywords: PUVA; Scleredema; methotrexate