title: Renal injury in neonates: use of "omics" for developing precision medicine in neonatology.
abstract: Preterm birth is associated with increased risks of morbidity and mortality along with increased healthcare costs. Advances in medicine have enhanced survival for preterm infants but the overall incidence of major morbidities has changed very little. Abnormal renal development is an important consequence of premature birth. Acute kidney injury (AKI) in the neonatal period is multifactorial and may increase lifetime risk of chronic kidney disease.Traditional biomarkers in newborns suffer from considerable confounders, limiting their use for early identification of AKI. There is a need to develop novel biomarkers that can identify, in real time, the evolution of renal dysfunction in an early diagnostic, monitoring and prognostic fashion. Use of "omics", particularly metabolomics, may provide valuable information regarding functional pathways underlying AKI and prediction of clinical outcomes.The emerging knowledge generated by the application of "omics" (genomics, proteomics, metabolomics) in neonatology provides new insights that can help to identify markers of early diagnosis, disease progression, and identify new therapeutic targets. Additionally, omics will have major implications in the field of personalized healthcare in the future. Here, we will review the current knowledge of different omics technologies in neonatal-perinatal medicine including biomarker discovery, defining as yet unrecognized biologic therapeutic targets, and linking of omics to relevant standard indices and long-term outcomes.
authors.affiliation: Department of Pediatrics, University of Kentucky College of Medicine, Lexington, Kentucky.
authors.forename: Mandar S
authors.initials: MS
authors.lastname: Joshi
authors.affiliation: Department of Pediatrics, University of Kentucky College of Medicine, Lexington, Kentucky.
authors.forename: Kelsey A
authors.initials: KA
authors.lastname: Montgomery
authors.affiliation: Department of Pediatrics, University of Kentucky College of Medicine, Lexington, Kentucky.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Giannone
authors.affiliation: Department of Pediatrics, University of Kentucky College of Medicine, Lexington, Kentucky.
authors.forename: John A
authors.initials: JA
authors.lastname: Bauer
authors.affiliation: Department of Pediatrics, University of Kentucky College of Medicine, Lexington, Kentucky.
authors.forename: Mina H
authors.initials: MH
authors.lastname: Hanna
mesh_terms: D058186:Acute Kidney Injury / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D023281:Genomics / Q000379:methods*; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D055432:Metabolomics / Q000379:methods*; D009359:Neonatology; D057285:Precision Medicine / Q000379:methods*; D011379:Prognosis; D040901:Proteomics / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers