title: Aneuploidy: a common and early evidence-based biomarker for carcinogens and reproductive toxicants.
abstract: Aneuploidy, defined as structural and numerical aberrations of chromosomes, continues to draw attention as an informative effect biomarker for carcinogens and male reproductive toxicants. It has been well documented that aneuploidy is a hallmark of cancer. Aneuploidies in oocytes and spermatozoa contribute to infertility, pregnancy loss and a number of congenital abnormalities, and sperm aneuploidy is associated with testicular cancer. It is striking that several carcinogens induce aneuploidy in somatic cells, and also adversely affect the chromosome compliment of germ cells. In this paper we review 1) the contributions of aneuploidy to cancer, infertility, and developmental abnormalities; 2) techniques for assessing aneuploidy in precancerous and malignant lesions and in sperm; and 3) the utility of aneuploidy as a biomarker for integrated chemical assessments of carcinogenicity, and reproductive and developmental toxicity.
authors.affiliation: Cesare Maltoni Cancer Research Center, Ramazzini Institute, 40010 Bentivoglio, Bologna, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Mandrioli
authors.affiliation: Cesare Maltoni Cancer Research Center, Ramazzini Institute, 40010 Bentivoglio, Bologna, Italy.
authors.forename: Fiorella
authors.initials: F
authors.lastname: Belpoggi
authors.affiliation: Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 21205, Baltimore, MD, USA.
authors.forename: Ellen K
authors.initials: EK
authors.lastname: Silbergeld
authors.affiliation: Department of Environmental and Occupational Health, Milken Institute School of Public Health, The George Washington University, 950 New Hampshire Ave. NW, 4th Floor, Washington, DC, 20052, USA. mperry@gwu.edu.
authors.forename: Melissa J
authors.initials: MJ
authors.lastname: Perry
mesh_terms: D000782:Aneuploidy; D000818:Animals; D015415:Biomarkers; D002273:Carcinogens / Q000633:toxicity; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000235:genetics; D012098:Reproduction; D013094:Spermatozoa / Q000502:physiology
chemical_list: D015415:Biomarkers; D002273:Carcinogens
keywords: Aneuploidy; Bioassays; Carcinogens; Chromosomes; Early diagnose; Endocrine disruptors; Laser scanning microscopy; Reproductive toxicants; Risk assessment; mFISH