title: Pulmonary Hypertension - New Trends of Diagnostic and Therapy.
abstract: Pulmonary hypertension is a pathophysiological state hemodynamically defined as the increase of the mean pulmonary arterial pressure above 25, or 30 mmHg at rest, measured by catheterization of the right heart. Laboratory findings usually reveals polycythemia, the ECG right ventricle hypertrophy, and x-ray characteristic of diseased branches (echocardiography and biomarkers such as B-type natriuretic peptide (BNP) and N-terminal pro-BNP hormones are potentially helpful tools in identifying PH). Echocardiography can be found the increase of the right atrium and ventricle, right ventricular hypertrophy, abnormal contraction of the interventricular septum, left ventricular diastolic dysfunction and decreased left ventricular size, with reduced volumes of systole and end diastole. Doppler confirming tricuspid regurgitation. Pharmacological therapy would represent a use: Calcium Channel Blockers, Prostacyclin Analogues, Endothelin Receptor Antagonists and Phosphodiesterase-5 Inhibitors. Alpha adrenergic antagonists, endothelial receptor subtype A (Bosentan, Tracller) with treatment of the underlying disease or anticongestive therapy, are recommended. In case of inadequate response to treatment with a specific drug, guidelines recommend the combined use of drugs from the basic three groups, using their synergism.
authors.affiliation: Clinic for Emergency Medicine, Clinical Centre of Sarajevo University, Sarajevo, Bosnia and Herzegovina.
authors.forename: Senad
authors.initials: S
authors.lastname: Pesto
authors.affiliation: Pediatric Clinic, Clinical Centre of Sarajevo University, Sarajevo, Bosnia and Herzegovina.
authors.forename: Zijo
authors.initials: Z
authors.lastname: Begic
authors.affiliation: Clinic for Radiology, Clinical Centre of Sarajevo University, Sarajevo, Bosnia and Herzegovina.
authors.forename: Sabina
authors.initials: S
authors.lastname: Prevljak
authors.affiliation: Health Care Centre of Sarajevo Canton, Sarajevo, Bosnia and Herzegovina.
authors.forename: Ehlimana
authors.initials: E
authors.lastname: Pecar
authors.affiliation: Clinic for Heart Diseases, Clinical Centre of Sarajevo University, Sarajevo, Bosnia and Herzegovina.
authors.forename: Nihad
authors.initials: N
authors.lastname: Kukavica
authors.affiliation: Health Care Centre, Maglaj, Bosnia and Herzegovina.
authors.forename: Edin
authors.initials: E
authors.lastname: Begic
mesh_terms: D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*
keywords: pulmonary hypertension; treatment