title: Randomized clinical trial to comparing efficacy of daily, weekly and monthly administration of vitamin D3.
abstract: The comparative efficacy and safety profiles of selected daily 1000 IU, weekly 7000 IU and monthly 30,000 IU vitamin D3-not previously investigated-will be evaluated. Here, a prospective, randomized clinical trial, comparing efficacy and safety of a daily single dose of 1000 IU (group A) to a once-weekly 7000 IU dose (group B), or monthly 30,000 IU dose (group C) of vitamin D3. The present study is a controlled, randomized, open-label, multicenter clinical trial, 3  months in duration. Sixty-four adult subjects with vitamin D deficiency (25OHD<20 ng/ml), were included according to the inclusion and exclusion criteria. Dose-responses for increases in serum vitamin 25OHD were statistically equivalent for each of the three groups: A, B and C. Outcomes were 13.0 ± 1.5; 12.6 ± 1.1 and 12.9 ± 0.9 ng/ml increases in serum 25OHD per 1000 IU, daily, weekly and monthly, respectively. The treatment of subjects with selected doses restored 25OHD values to levels above 20 ng/ml in all groups. Treatment with distinct administration frequency of vitamin D3did not exhibit any differences in safety parameters. The daily, weekly and monthly administrations of daily equivalent of 1000 IU of vitamin D3provide equal efficacy and safety profiles.
authors.affiliation: 1st Department of Internal Medicine, Semmelweis University Faculty of Medicine, Koranyi Sándor u. str 2/a, Budapest, 1083, Hungary. takacs.istvan@med.semmelweis-univ.hu.
authors.forename: István
authors.initials: I
authors.lastname: Takács
authors.affiliation: Department of Pharmaceutical Surveillance and Economy, University of Debrecen Faculty of Pharmacy, Nagyerdei krt 98, Debrecen, 4032, Hungary.
authors.forename: Béla E
authors.initials: BE
authors.lastname: Tóth
authors.affiliation: National Institute of Rheumatology and Physiotherapy, Frankel Leo str. 25-29, Budapest, 1023, Hungary.
authors.forename: László
authors.initials: L
authors.lastname: Szekeres
authors.affiliation: 1st Department of Internal Medicine, Semmelweis University Faculty of Medicine, Koranyi Sándor u. str 2/a, Budapest, 1083, Hungary.
authors.forename: Boglárka
authors.initials: B
authors.lastname: Szabó
authors.affiliation: 1st Department of Internal Medicine, Semmelweis University Faculty of Medicine, Koranyi Sándor u. str 2/a, Budapest, 1083, Hungary.
authors.forename: Bence
authors.initials: B
authors.lastname: Bakos
authors.affiliation: 1st Department of Internal Medicine, Semmelweis University Faculty of Medicine, Koranyi Sándor u. str 2/a, Budapest, 1083, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Lakatos
mesh_terms: D000328:Adult; D000368:Aged; D002112:Calcifediol / Q000097:blood; D002762:Cholecalciferol / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D015331:Cohort Studies; D019587:Dietary Supplements / Q000009:adverse effects; D005260:Female; D006801:Humans; D006814:Hungary; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D013607:Tablets; D013810:Therapeutic Equivalency; D013997:Time Factors; D014808:Vitamin D Deficiency / Q000097:blood / Q000178:diet therapy*
chemical_list: D013607:Tablets; D002762:Cholecalciferol; D002112:Calcifediol
keywords: Deficiency; Efficacy; Treatment; Vitamin D3