title: Association between expression of DNA mismatch repair genes and clinical features and prognosis of patients with radical resection of colon cancer.
abstract: The aim of this study was to investigate the clinical significance of the expression of DNA mismatch repair (MMR) genes in patients subjected to radical surgical removal of colon cancer, as well as their correlation with disease prognosis. Ninety stage II and III colon cancer patients who received laparoscopic radical resection of colon cancer at our hospital were recruited in this study. The expression of hMLH1, hMSH2, hMSH6, and hPMS2 in the resected tumor tissues was examined by SP immunohistochemistry, in order to analyze the relationship between defective DNA MMR (dMMR) and the clinico-pathological features and prognosis of colon cancer. Patients were followed up over a period of 5-35 months, and the Kaplan-Meier survival curve was plotted. dMMR was confirmed in 27 subjects (30.0%), among whom recurrence with metastasis and death was reported in 5 (18.5%) and 2 (7.4%) patients, respectively. The remaining 63 subjects displayed proficient DNA MMR (pMMR); among these, 19 (30.2%) and 7 (11.1%) recurrences with metastasis and death were reported, respectively. dMMR showed no significant correlation with gender, age, or therapeutic modality (P > 0.05), but was significantly correlated with the degree of differentiation, tumor location, number of resected lymph nodes, presence of ileus, and TNM stage (P < 0.05). The prognosis of patients with dMMR was better than that of patients with pMMR. dMMR serves as a biomarker for the prognosis of stage II/III colon cancers.
authors.affiliation: Department of General Surgery, Yishui Central Hospital of Linyi, Linyi, Shandong, China.
authors.forename: J B
authors.initials: JB
authors.lastname: Wang
authors.affiliation: Department of Medical Oncology, Yishui Central Hospital of Linyi, Linyi, Shandong, China.
authors.forename: D L
authors.initials: DL
authors.lastname: Ma
authors.affiliation: Department of Medical Oncology, Yishui Central Hospital of Linyi, Linyi, Shandong, China.
authors.forename: J Y
authors.initials: JY
authors.lastname: Li
authors.affiliation: Department of General Surgery, Yishui Central Hospital of Linyi, Linyi, Shandong, China.
authors.forename: Q D
authors.initials: QD
authors.lastname: Sun
authors.affiliation: Department of Infectious Diseases, Yishui Central Hospital of Linyi, Linyi, Shandong, China 2369475216@qq.com.
authors.forename: Y E
authors.initials: YE
authors.lastname: Liu
mesh_terms: D000368:Aged; D015415:Biomarkers; D003082:Colectomy; D003110:Colonic Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D053843:DNA Mismatch Repair; D045643:DNA Repair Enzymes / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015870:Gene Expression; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis
chemical_list: D015415:Biomarkers; D045643:DNA Repair Enzymes