title: Influencing factors of transient elastography in detecting liver stiffness.
abstract: Liver stiffness, which correlates well with liver fibrosis stage, can be measured noninvasively by transient elastography, also known as Fibroscan. The present study aimed to determine the independent factors influencing Fibroscan detection by multiple regression analysis. A total of 181 patients who required liver biopsy were enrolled. Liver stiffness measurement (LSM) was detected by Fibroscan on the day of liver biopsy, while clinical information and routine biochemical examination results were also collected. Correlation was analyzed by Spearman's correlation, and multiple regression analysis was performed to analyze the independent influencing factors. The results demonstrated that platelet (PLT) levels, serum albumin (ALB), prothrombin activity (PTA) and body mass index (BMI) were independent predictors of liver stiffness. The contribution of these four predictors to the regression equation was in the following descending order: PLT (negative correlation) > ALB (negative correlation) > PTA (negative correlation) > BMI (positive correlation). In conclusion, the parameters of PLT, ALB, PTA and BMI are independent predicting factors affecting Fibroscan detection. Therefore, the diagnosis and evaluation of liver fibrosis should comprehensively consider the results of Fibroscan, and clinical and laboratory examinations.
authors.affiliation: Department of Ultrasound, Jinan Infectious Disease Hospital, Jinan, Shandong 250021, P.R. China; Department of Ultrasound, Shandong University, Jinan, Shandong 250014, P.R. China.
authors.forename: Rong
authors.initials: R
authors.lastname: Shan
authors.affiliation: Department of Ultrasound, Jinan Maternity and Child Care Hospital, Jinan, Shandong 250000, P.R. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yin
authors.affiliation: Department of Emergency, Jinan Center Hospital, Jinan, Shandong 250001, P.R. China.
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Yang
authors.affiliation: Department of Ultrasound, Jinan Infectious Disease Hospital, Jinan, Shandong 250021, P.R. China.
authors.forename: Jianzhi
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Ultrasound, Jinan Infectious Disease Hospital, Jinan, Shandong 250021, P.R. China.
authors.forename: Meifang
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Ultrasound, Jinan Infectious Disease Hospital, Jinan, Shandong 250021, P.R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Department of Ultrasound, Jinan Infectious Disease Hospital, Jinan, Shandong 250021, P.R. China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Shao
authors.affiliation: Department of Oncology, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong 250014, P.R. China.
authors.forename: Aiguang
authors.initials: A
authors.lastname: Wang
keywords: Fibroscan; independent predictor; liver stiffness; multiple regression analysis