title: Secretory leukocyte protease inhibitor promising protective roles in obesity-associated atherosclerosis.
abstract: Secretory leukocyte protease inhibitor (SLPI), a serine protease inhibitor, which was most commonly examined in mucosal fluids such as saliva, is a versatile molecule and plays non-redundant roles. In addition to its anti-protease activity, SLPI has been shown to express anti-bacterial, anti-viral, anti-fungal, and anti-inflammatory properties as well as participating in innate and adaptive immune responses, most of which has been well documented. Recently, it is reported that SLPI is expressed in adipocytes and adipose tissue where it could play an important feedback role in the resolution of inflammation. Furthermore, circulating SLPI has been shown to correlate with progressive metabolic dysfunction. Moreover, adenoviral gene delivery of elafin and SLPI attenuates nuclear factor-κB-dependent inflammatory responses of human endothelial cells and macrophages to atherogenic stimuli. This review contributes to unraveling the protective role of SLPI in obesity-related atherosclerosis development, and the potential role in preventing arterial plaque rupture.
authors.affiliation: 1 Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410008, China.|2 Post-doctoral Mobile Stations for Basic Medicine, Institute of Cardiovascular Disease and Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang 421001, China.|3 Department of Cardiology, First People's Hospital of Chenzhou, University of South China, Chenzhou 423000, China.
authors.forename: Qiao-Qing
authors.initials: QQ
authors.lastname: Zhong
authors.affiliation: 3 Department of Cardiology, First People's Hospital of Chenzhou, University of South China, Chenzhou 423000, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.affiliation: 3 Department of Cardiology, First People's Hospital of Chenzhou, University of South China, Chenzhou 423000, China.
authors.forename: Yun-Feng
authors.initials: YF
authors.lastname: Li
authors.affiliation: 2 Post-doctoral Mobile Stations for Basic Medicine, Institute of Cardiovascular Disease and Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang 421001, China.|4 Department of Science and Teaching, Children's Hospital of Hunan Province, Changsha 410007, China.
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Peng
authors.affiliation: 2 Post-doctoral Mobile Stations for Basic Medicine, Institute of Cardiovascular Disease and Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang 421001, China.
authors.forename: Zhi-Sheng
authors.initials: ZS
authors.lastname: Jiang
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D000273:Adipose Tissue / Q000166:cytology / Q000378:metabolism; D000893:Anti-Inflammatory Agents / Q000378:metabolism*; D000975:Antioxidants / Q000378:metabolism*; D050197:Atherosclerosis / Q000150:complications / Q000473:pathology*; D053492:Elafin / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000517:prevention & control; D009765:Obesity / Q000209:etiology / Q000473:pathology*; D058226:Plaque, Atherosclerotic / Q000473:pathology*; D053481:Secretory Leukocyte Peptidase Inhibitor / Q000378:metabolism*
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D053492:Elafin; C506806:PI3 protein, human; C506814:SLPI protein, human; D053481:Secretory Leukocyte Peptidase Inhibitor
keywords: Secretory leukocyte protease inhibitor; adipokine; adipose tissue inflammation; atherosclerosis; inflammation; obesity