title: Correlation of BRAF mutation and SUVmaxlevels in thyroid cancer patients incidentally detected in18F-fluorodeoxyglucose positron emission tomography.
abstract: The prognostic importance of18F-fluorodeoxyglucose avidity in primary thyroid tumor and molecular basis responsible for its mechanism has not yet been well characterized. In this study, we aimed to evaluate the correlation between the maximum standardized uptake levels and B-type Raf kinase mutation positivity in incidentally detected papillary thyroid cancer patients during18F-fluorodeoxyglucose positron emission tomography examination. We retrospectively evaluated 687318F-fluorodeoxyglucose-positron emission tomography scans of consecutive subjects from a database search for tumor staging in 2014 at our hospital Nuclear Medicine Center. In total, 135 patients had focal18F-fluorodeoxyglucose uptake in the thyroid. Of these, 76 patients had fine-needle aspiration biopsy.18F-fluorodeoxyglucose-maximum standardized uptake of the positron emission tomography-detected nodules was recorded. B-type Raf kinase (V600E) mutation and p53 protein expression were evaluated in papillary thyroid cancer patients. The incidence of thyroid incidentaloma in18F-fluorodeoxyglucose-maximum standardized uptake scans was 2 % (135/6873). Of the 76 patients evaluated, 41 % (n = 31) were diagnosed papillary thyroid cancer. B-type Raf kinase mutation was positive in 51 % (17/30) of the papillary thyroid cancer patients. Maximum standardized uptake levels of the nodules (≥1 cm) were significantly higher in B-type Raf kinase-mutated papillary thyroid cancer patients than in non-mutated patients [16.6 (10.4-27.9) vs. 9.7 (6.8-11.1); P = 0.007]. Correlation analysis revealed that maximum standardized uptake was significantly associated with B-type Raf kinase mutation positivity (r = 0.519; P = 0.005). Logistic regression analysis showed an association between maximum standardized uptake and B-type Raf kinase mutation positivity even after adjustment for age and gender (P = 0.01). B-type Raf kinase mutation is closely related to18F-fluorodeoxyglucose-positron emission tomography maximum standardized uptake levels in patients with incidentally detected papillary thyroid cancer.
authors.affiliation: Department of Endocrinology and Metabolism, Kartal Dr. Lutfi Kirdar Training and Research Hospital, Istanbul, 34890, Turkey.
authors.forename: Aysenur
authors.initials: A
authors.lastname: Ozderya
authors.affiliation: Department of Endocrinology and Metabolism, Kartal Dr. Lutfi Kirdar Training and Research Hospital, Istanbul, 34890, Turkey. suletemizkan@yahoo.com.
authors.forename: Sule
authors.initials: S
authors.lastname: Temizkan
authors.affiliation: Department of Pathology, Kartal Dr. Lutfi Kirdar Training and Research Hospital, Istanbul, 34890, Turkey.
authors.forename: Aylin Ege
authors.initials: AE
authors.lastname: Gul
authors.affiliation: Department of Nuclear Medicine, Kartal Dr. Lutfi Kirdar Training and Research Hospital, Istanbul, 34890, Turkey.
authors.forename: Sule
authors.initials: S
authors.lastname: Ozugur
authors.affiliation: Department of Family Medicine, Kartal Dr. Lutfi Kirdar Training and Research Hospital, Istanbul, 34890, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Sargin
authors.affiliation: Department of Endocrinology and Metabolism, Kartal Dr. Lutfi Kirdar Training and Research Hospital, Istanbul, 34890, Turkey.
authors.forename: Kadriye
authors.initials: K
authors.lastname: Aydin
mesh_terms: D000328:Adult; D002291:Carcinoma, Papillary / Q000000981:diagnostic imaging* / Q000235:genetics; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D033162:Incidental Findings; D008297:Male; D008875:Middle Aged; D009154:Mutation; D049268:Positron-Emission Tomography / Q000379:methods; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D013961:Thyroid Gland / Q000000981:diagnostic imaging*; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf
keywords: 18FDG-PET; BRAF; Differantiated thyroid cancer; P53 protein expression