title: Far from the Madding Crowd: the Molecular Basis for Immunological Escape ofPlasmodium falciparum.
abstract: Like Thomas Hardy's famous novel Far from the Madding Crowd,Plasmodium falciparumparasites display their most relevant survival structures (proteins) involved in host cell invasion far away from the immune system's susceptible regions, displaying tremendous genetic variability, to attract the immune response and escape immune pressure. The 3D structure localisation of the conserved amino acid sequences of this deadly parasite's most relevant proteins involved in host cell invasion, as well as the location of the highly polymorphic, highly immunogenic regions, clearly demonstrates that such structures are far apart, sometimes 90° to 180° opposite, thereby rendering the immune response useless. It is also shown here that these conserved, functionally-relevant structures are immunologically silent, since no immune response has been induce.
authors.affiliation: Fundación Instituto de Inmunología de Colombia (FIDIC), Bogotá, Colombia.
authors.forename: Manuel E
authors.initials: ME
authors.lastname: Patarroyo
authors.affiliation: Fundación Instituto de Inmunología de Colombia (FIDIC), Bogotá, Colombia.
authors.forename: Jorge
authors.initials: J
authors.lastname: Aza-Conde
authors.affiliation: Fundación Instituto de Inmunología de Colombia (FIDIC), Bogotá, Colombia.
authors.forename: Armando
authors.initials: A
authors.lastname: Moreno-Vranich
authors.affiliation: Fundación Instituto de Inmunología de Colombia (FIDIC), Bogotá, Colombia.
authors.forename: Laura
authors.initials: L
authors.lastname: Pabón
authors.affiliation: Fundación Instituto de Inmunología de Colombia (FIDIC), Bogotá, Colombia.
authors.forename: Yahson
authors.initials: Y
authors.lastname: Varela
authors.affiliation: Fundación Instituto de Inmunología de Colombia (FIDIC), Bogotá, Colombia.
authors.forename: Manuel A
authors.initials: MA
authors.lastname: Patarroyo
mesh_terms: D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology; D006790:Host-Parasite Interactions / Q000276:immunology*; D016778:Malaria, Falciparum / Q000276:immunology*; D010963:Plasmodium falciparum / Q000276:immunology*
chemical_list: D000953:Antigens, Protozoan