title: Changes in Health-Related Quality of Life During Rehabilitation in Patients With Operable Lung Cancer: A Feasibility Study (PROLUCA).
abstract: Surgical resection in patients with non-small cell lung cancer (NSCLC) may be associated with significant morbidity, functional limitations, and decreased quality of life.
  
  
  
  The objective is to present health-related quality of life (HRQoL) changes over time before and 1 year after surgery in patients with NSCLC participating in a rehabilitation program.
  
  
  
  Forty patients with NSCLC in disease stage I to IIIa, referred for surgical resection at the Department of Cardiothoracic Surgery RT, Rigshospitalet, were included in the study. The rehabilitation program comprised supervised group exercise program, 2 hours weekly for 12 weeks, combined with individual counseling. The study endpoints were self-reported HRQoL (Functional Assessment of Cancer Therapy-Lung, European Organization for Research and Treatment in Cancer-Quality of Life Questionnaire-QLQ-C30, Short-Form-36) and self-reported distress, anxiety, depression, and social support (National Comprehensive Cancer Network Distress Thermometer, Hospital Anxiety and Depression Scale, Multidimensional Scale of Perceived Social Support), measured presurgery, postintervention, 6 months, and 1 year after surgery.
  
  
  
  Forty patients were included, 73% of whom completed rehabilitation. Results on emotional well-being ( P < .0001), global quality of life ( P = .0032), and mental health component score ( P = .0004) showed an overall statistically significant improvement during the study.
  
  
  
  This feasibility study demonstrated that global quality of life, mental health, and emotional well-being improved significantly during the study, from time of diagnosis until 1 year after resection, in patients with NSCLC participating in rehabilitation.
authors.affiliation: 1 Copenhagen Centre for Cancer and Health, Copenhagen, Denmark.
authors.forename: Maja S
authors.initials: MS
authors.lastname: Sommer
authors.affiliation: 1 Copenhagen Centre for Cancer and Health, Copenhagen, Denmark.
authors.forename: Karen
authors.initials: K
authors.lastname: Trier
authors.affiliation: 1 Copenhagen Centre for Cancer and Health, Copenhagen, Denmark.
authors.forename: Jette
authors.initials: J
authors.lastname: Vibe-Petersen
authors.affiliation: 2 University of Copenhagen, Copenhagen, Denmark.
authors.forename: Karl B
authors.initials: KB
authors.lastname: Christensen
authors.affiliation: 3 Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Malene
authors.initials: M
authors.lastname: Missel
authors.affiliation: 3 Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Merete
authors.initials: M
authors.lastname: Christensen
authors.affiliation: 4 Bispebjerg University Hospital, Copenhagen, Denmark.
authors.forename: Klaus R
authors.initials: KR
authors.lastname: Larsen
authors.affiliation: 3 Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.|4 Bispebjerg University Hospital, Copenhagen, Denmark.
authors.forename: Seppo W
authors.initials: SW
authors.lastname: Langer
authors.affiliation: 2 University of Copenhagen, Copenhagen, Denmark.
authors.forename: Carsten
authors.initials: C
authors.lastname: Hendriksen
authors.affiliation: 3 Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.|5 Gentofte University Hospital, Hellerup, Denmark.
authors.forename: Paul F
authors.initials: PF
authors.lastname: Clementsen
authors.affiliation: 3 Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Jesper H
authors.initials: JH
authors.lastname: Pedersen
authors.affiliation: 2 University of Copenhagen, Copenhagen, Denmark.
authors.forename: Henning
authors.initials: H
authors.lastname: Langberg
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001007:Anxiety / Q000523:psychology; D002289:Carcinoma, Non-Small-Cell Lung / Q000523:psychology* / Q000534:rehabilitation; D003863:Depression / Q000523:psychology; D004644:Emotions / Q000502:physiology; D015444:Exercise / Q000523:psychology; D005081:Exercise Therapy / Q000379:methods; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000523:psychology* / Q000534:rehabilitation*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods; D011788:Quality of Life / Q000523:psychology*; D012944:Social Support; D011795:Surveys and Questionnaires
keywords: HRQoL; NSCLC; exercise; lung cancer; rehabilitation