title: Nick Your DNA, Mark Your Chromatin.
abstract: DNA damage induces chemical and structural changes in our chromatin-embedded genome. In a recent issue of Nature Communications, Grundy et al. (2016) identify a role for PARP3 in the repair of single-strand breaks and reveal that PARP3 mono-ADP-ribosylates nucleosomal histone H2B.
authors.affiliation: Biomedical Center, Physiological Chemistry, Ludwig-Maximilians-University of Munich, Großhaderner Street 9, 82152 Planegg-Martinsried, Germany.
authors.forename: Aurelio P
authors.initials: AP
authors.lastname: Nardozza
authors.affiliation: Biomedical Center, Physiological Chemistry, Ludwig-Maximilians-University of Munich, Großhaderner Street 9, 82152 Planegg-Martinsried, Germany; Center for Integrated Protein Science Munich (CIPSM), 81377 Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), 80336 Munich, Germany. Electronic address: andreas.ladurner@med.lmu.de.
authors.forename: Andreas G
authors.initials: AG
authors.lastname: Ladurner
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000235:genetics* / Q000378:metabolism; D045744:Cell Line, Tumor; D002645:Chickens; D002843:Chromatin / Q000737:chemistry* / Q000378:metabolism; D004247:DNA / Q000235:genetics* / Q000378:metabolism; D053904:DNA Breaks, Single-Stranded; D004260:DNA Repair; D005786:Gene Expression Regulation; D006657:Histones / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D011065:Poly(ADP-ribose) Polymerases / Q000235:genetics* / Q000378:metabolism; D014982:Xenopus laevis
chemical_list: D018797:Cell Cycle Proteins; D002843:Chromatin; D006657:Histones; D004247:DNA; C480979:PARP3 protein, human; D011065:Poly(ADP-ribose) Polymerases