title: Dietary inflammatory index and risk of epithelial ovarian cancer in African American women.
abstract: Chronic inflammation has been implicated in the development of epithelial ovarian cancer (EOC); yet the contribution of inflammatory foods and nutrients to EOC risk has been understudied. We investigated the association between the dietary inflammatory index (DII), a novel literature-derived tool to assess the inflammatory potential of one's diet, and EOC risk in African American (AA) women in the African American Cancer Epidemiology Study, the largest population-based case-control study of EOC in AA women to date. The energy-adjusted DII (E-DII) was computed per 1,000 kilocalories from dietary intake data collected through a food frequency questionnaire, which measured usual dietary intake in the year prior to diagnosis for cases or interview for controls. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable logistic regression for the association between the E-DII and EOC risk. 493 cases and 662 controls were included in the analyses. We observed a 10% increase in EOC risk per a one-unit change in the E-DII (OR = 1.10, 95% CI = 1.03-1.17). Similarly, women consuming the most pro-inflammatory diet had a statistically significant increased EOC risk in comparison to the most anti-inflammatory diet (ORQuartile4/Quartile1= 1.72; 95% CI = 1.18-2.51). We also observed effect modification by age (p < 0.05), where a strong, significant association between the E-DII and EOC risk was observed among women older than 60 years, but no association was observed in women aged 60 years or younger. Our findings suggest that a more pro-inflammatory diet was associated with an increased EOC risk, especially among women older than 60 years.
authors.affiliation: Department of Public Health Sciences, University of Virginia, Charlottesville, VA.
authors.forename: Lauren C
authors.initials: LC
authors.lastname: Peres
authors.affiliation: Department of Population Science, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ.
authors.forename: Elisa V
authors.initials: EV
authors.lastname: Bandera
authors.affiliation: Department of Population Science, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ.
authors.forename: Bo
authors.initials: B
authors.lastname: Qin
authors.affiliation: Department of Public Health Sciences, University of Virginia, Charlottesville, VA.
authors.forename: Kristin A
authors.initials: KA
authors.lastname: Guertin
authors.affiliation: Cancer Prevention and Control Program, University of South Carolina, Columbia, SC.|Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC.
authors.forename: Nitin
authors.initials: N
authors.lastname: Shivappa
authors.affiliation: Cancer Prevention and Control Program, University of South Carolina, Columbia, SC.|Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC.
authors.forename: James R
authors.initials: JR
authors.lastname: Hebert
authors.affiliation: Department of Public Health Sciences, University of Virginia, Charlottesville, VA.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Abbott
authors.affiliation: Hollings Cancer Center and Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Alberg
authors.affiliation: Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH.
authors.forename: Jill
authors.initials: J
authors.lastname: Barnholtz-Sloan
authors.affiliation: Cancer Prevention and Population Sciences Program, Baylor College of Medicine, One Baylor Plaza, Houston, TX.
authors.forename: Melissa
authors.initials: M
authors.lastname: Bondy
authors.affiliation: Department of Oncology and the Karmanos Cancer Institute Population Studies and Disparities Research Program, Wayne State University School of Medicine, Detroit, MI.
authors.forename: Michele L
authors.initials: ML
authors.lastname: Cote
authors.affiliation: Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL.
authors.forename: Ellen
authors.initials: E
authors.lastname: Funkhouser
authors.affiliation: Department of Community and Family Medicine, Duke University Medical Center, Durham, NC.
authors.forename: Patricia G
authors.initials: PG
authors.lastname: Moorman
authors.affiliation: Department of Epidemiology, Louisiana State University Health Sciences Center School of Public Health, New Orleans, LA.
authors.forename: Edward S
authors.initials: ES
authors.lastname: Peters
authors.affiliation: Department of Oncology and the Karmanos Cancer Institute Population Studies and Disparities Research Program, Wayne State University School of Medicine, Detroit, MI.
authors.forename: Ann G
authors.initials: AG
authors.lastname: Schwartz
authors.affiliation: Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN.
authors.forename: Paul D
authors.initials: PD
authors.lastname: Terry
authors.affiliation: Department of Public Health Sciences, University of Virginia, Charlottesville, VA.
authors.forename: Fabian
authors.initials: F
authors.lastname: Camacho
authors.affiliation: Department of Community and Family Medicine, Duke University Medical Center, Durham, NC.
authors.forename: Frances
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Public Health Sciences, University of Virginia, Charlottesville, VA.
authors.forename: Joellen M
authors.initials: JM
authors.lastname: Schildkraut
mesh_terms: D000328:Adult; D001741:Black or African American; D000077216:Carcinoma, Ovarian Epithelial; D016022:Case-Control Studies; D004032:Diet / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications*; D016015:Logistic Models; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000209:etiology*; D016017:Odds Ratio; D010051:Ovarian Neoplasms / Q000209:etiology*; D012307:Risk Factors; D055815:Young Adult
keywords: African American; diet; dietary inflammatory index; inflammation; ovarian cancer