title: An observational clinical and video-polysomnographic study of the effects of rotigotine in sleep disorder in Parkinson's disease.
abstract: OBJECTIVE
  Sleep disturbance is common in Parkinson's disease (PD) and negatively impacts quality of life. There is little data on how dopamine agonists influence nocturnal sleep in PD, particularly in sleep laboratory data to measure sleep parameters and their changes objectively. The goal of this open-label study was to objectively evaluate the effect of rotigotine on sleep in PD patients by video-polysomnographic methods.
  
  
  METHODS
  A total of 25 PD patients with complaints of nocturnal sleep impairment were enrolled. The sleep quality before and after stable rotigotine therapy was evaluated subjectively through questionnaire assessments and objectively measured by video-polysomnographic methods. The Parkinsonism, depression, anxiety, and quality of life of PD patients were also evaluated through questionnaire assessments.
  
  
  RESULTS
  At the end of rotigotine treatment, the PD daytime functioning, motor performance, depression, subjective quality of sleep, and the quality of life improved. Video-polysomnographic analysis showed that the sleep efficiency and stage N1% were increased, while the sleep latency, wake after sleep onset, and the periodic leg movements in sleep index were decreased after rotigotine treatment.
  
  
  CONCLUSIONS
  Video-polysomnographic analysis confirmed the subjective improvement of sleep after rotigotine treatment. This observation suggests that in PD rotigotine is a treatment option for patients complaining from sleep disturbances.
authors.affiliation: Department of Neurology, No. 88 Hospital of PLA, Taian, Shandong, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, 200003, China.
authors.forename: Yue-Chang
authors.initials: YC
authors.lastname: Yang
authors.affiliation: Sleep Center, Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Dan-Mei
authors.initials: DM
authors.lastname: Lan
authors.affiliation: Sleep Center, Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Hui -Juan
authors.initials: H-
authors.lastname: Wu
authors.affiliation: Department of Neurology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, 200003, China. zhaozx2014@126.com.
authors.forename: Zhong-Xin
authors.initials: ZX
authors.lastname: Zhao
mesh_terms: D000368:Aged; D018491:Dopamine Agonists / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D017286:Polysomnography / Q000187:drug effects* / Q000379:methods*; D011788:Quality of Life / Q000523:psychology; D012894:Sleep Stages / Q000187:drug effects; D012893:Sleep Wake Disorders / Q000175:diagnosis / Q000188:drug therapy*; D011795:Surveys and Questionnaires; D013764:Tetrahydronaphthalenes / Q000627:therapeutic use*; D013876:Thiophenes / Q000627:therapeutic use*; D014741:Video Recording / Q000379:methods*
chemical_list: D018491:Dopamine Agonists; D013764:Tetrahydronaphthalenes; D013876:Thiophenes; C047508:rotigotine
keywords: Dopamine agonist; Parkinson’s disease; Rotigotine transdermal patch; Sleep disorders; Video-polysomnography, drug therapy