title: Antibacterial Adhesion of Poly(methyl methacrylate) Modified by Borneol Acrylate.
abstract: Poly(methyl methacrylate) (PMMA) is a widely used biomaterial. But there is still a challenge facing its unwanted bacterial adhesion because the subsequent biofilm formation usually leads to failure of related implants. Herein, we present a borneol-modified PMMA based on a facile and effective stereochemical strategy, generating antibacterial copolymer named as P(MMA-co-BA). It was synthesized by free radical polymerization and studied with different ratio between methyl methacrylate (MMA) and borneol acrylate (BA) monomers. NMR, GPC, and EA, etc., were used to confirm their chemical features. Their films were challenged with Escherichia coli (Gram-negative) and Bacillus subtilis (Gram-positive), showing a BA content dependent antibacterial performance. The minimum effective dose should be 10%. Then in vivo subcutaneous implantations in mice demonstrated their biocompatibilities through routine histotomy and HE staining. Therefore, P(MMA-co-BA)s not only exhibited their unique antibacterial character but also suggested a potential for the safe usage of borneol-modified PMMA frame and devices for further implantation.
authors.affiliation: Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology , Beijing 100029, P. R. China.
authors.forename: Xueli
authors.initials: X
authors.lastname: Sun
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University , Beijing 100191, P. R. China.|Department of Advanced Interdisciplinary Studies, Institute of Basic Medical Sciences , Beijing 100850, P. R. China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Qian
authors.affiliation: Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology , Beijing 100029, P. R. China.
authors.forename: Lingqiong
authors.initials: L
authors.lastname: Luo
authors.affiliation: Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology , Beijing 100029, P. R. China.
authors.forename: Qipeng
authors.initials: Q
authors.lastname: Yuan
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University , Beijing 100191, P. R. China.|Department of Advanced Interdisciplinary Studies, Institute of Basic Medical Sciences , Beijing 100850, P. R. China.
authors.forename: Ximin
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Chemistry, Tsinghua University , Beijing 100084, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Tao
authors.affiliation: Department of Chemistry, Tsinghua University , Beijing 100084, P. R. China.
authors.forename: Yen
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology , Beijing 100029, P. R. China.
authors.forename: Xing
authors.initials: X
authors.lastname: Wang
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D000818:Animals; D000900:Anti-Bacterial Agents; D001892:Camphanes; D051379:Mice; D019904:Polymethyl Methacrylate
chemical_list: D000179:Acrylates; D000900:Anti-Bacterial Agents; D001892:Camphanes; D019904:Polymethyl Methacrylate; C022871:isoborneol
keywords: antibacterial adhesion; borneol; copolymer; implant; poly(methyl methacrylate)