title: Outcomes in Postoperative Pediatric Cardiac Surgical Patients Who Received an Antiepileptic Drug.
abstract: BACKGROUND:Advances in cardiac operations over the last few decades, including corrective operations in early life, have dramatically increased the survival of children with congenital heart disease. However, postoperative care has been associated with neurologic complications, with seizures being the most common manifestation. The primary objective of this study is to describe the outcomes in pediatric patients who received an antiepileptic drug (AED) post-cardiac surgery.METHOD:A retrospective cohort study was performed in all patients less than 18 years of age who received an AED in the cardiovascular intensive care unit at Texas Children's Hospital from June 2002 until June 2012. Cardiac surgical patients initiated on phenobarbital, phenytoin, and levetiracetam were queried. Patients were excluded if the AED was not initiated on the admission for surgery. Patients who received 1 AED were compared to patients who received 2 AED, and differences in outcomes examined between the 3 AEDs used were evaluated.RESULTS:A total of 37 patients met the study criteria. Patients were initiated on an AED a median of 4 days following surgery and became seizure free a median of 1 day after initiation, with 65% remaining seizure free after the first dose. Half of all patients required 2 AEDs for seizure control, with a higher proportion of adolescents requiring 2 AEDs (p = 0.04). No differences were found when comparing the collected outcomes between phenobarbital, fosphenytoin, or levetiracetam.CONCLUSION:No adverse events were reported with the AEDs reviewed. Further work is necessary to evaluate long-term neurodevelopmental outcomes in this population and whether outcomes are a result of the AED or of other clinical sequelae.
authors.affiliation: Texas Children's Hospital, Department of Pharmacy, Houston, Texas, Houston, Texas ; Baylor College of Medicine, Department of Pediatrics, Division of Pediatric Neurology, Houston, Texas.
authors.forename: Mindl M
authors.initials: MM
authors.lastname: Messinger
authors.affiliation: Texas Children's Hospital, Department of Pharmacy, Houston, Texas, Houston, Texas.
authors.forename: Kimberly L
authors.initials: KL
authors.lastname: Dinh
authors.affiliation: Texas Children's Hospital, Department of Pharmacy, Houston, Texas, Houston, Texas.
authors.forename: Erin J
authors.initials: EJ
authors.lastname: McDade
authors.affiliation: Texas Children's Hospital, Department of Pharmacy, Houston, Texas, Houston, Texas ; Baylor College of Medicine, Department of Pediatrics, Section of Pediatric Cardiology, Houston, Texas.
authors.forename: Brady S
authors.initials: BS
authors.lastname: Moffett
authors.affiliation: Baylor College of Medicine, Department of Pediatrics, Division of Pediatric Neurology, Houston, Texas.
authors.forename: Angus A
authors.initials: AA
authors.lastname: Wilfong
authors.affiliation: Baylor College of Medicine, Department of Pediatrics, Section of Pediatric Cardiology, Houston, Texas.
authors.forename: Antonio G
authors.initials: AG
authors.lastname: Cabrera
keywords: antiepileptic drug; cardiac surgery; fosphenytoin; levetiracetam; pediatric; phenobarbital; phenytoin