title: Programmed photosensitizer conjugated supramolecular nanocarriers with dual targeting ability for enhanced photodynamic therapy.
abstract: A programmed supramolecular nanocarrier was developed for multistage targeted photodynamic therapy. This smart nanocarrier exhibited enhanced cellular uptake and controlled mitochondria targeting, as well as an excellent photodynamic therapeutic effect after light irradiation.
authors.affiliation: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China. jinqiao@zju.edu.cn jijian@zju.edu.cn.
authors.forename: Hongxin
authors.initials: H
authors.lastname: Tong
authors.affiliation: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China. jinqiao@zju.edu.cn jijian@zju.edu.cn.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Du
authors.affiliation: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China. jinqiao@zju.edu.cn jijian@zju.edu.cn.
authors.forename: Huan
authors.initials: H
authors.lastname: Li
authors.affiliation: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China. jinqiao@zju.edu.cn jijian@zju.edu.cn.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Jin
authors.affiliation: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China. jinqiao@zju.edu.cn jijian@zju.edu.cn.
authors.forename: Youxiang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China. jinqiao@zju.edu.cn jijian@zju.edu.cn.
authors.forename: Jian
authors.initials: J
authors.lastname: Ji
mesh_terms: D000595:Amino Acid Sequence; D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D049109:Cell Proliferation / Q000187:drug effects; D002735:Chlorophyllides; D004337:Drug Carriers / Q000737:chemistry*; D005260:Female; D006801:Humans; D008027:Light; D061986:MCF-7 Cells; D018613:Microscopy, Confocal; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D053758:Nanoparticles / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D011166:Porphyrins / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D002735:Chlorophyllides; D004337:Drug Carriers; D010455:Peptides; D017319:Photosensitizing Agents; D011166:Porphyrins; D047392:beta-Cyclodextrins; C062985:phytochlorin; C031215:betadex