title: Association of glutathione S-transferaseGSTM1andGSTT1deletion polymorphisms with obesity and their relationship with body mass index, lipoprotein and hypertension among young age Saudis.
abstract: OBJECTIVE
  Persistent oxidative stress is one of the several risk factors that may be associated with the etiology of obesity. The present study is aimed to investigate association betweenGSTM1andGSTT1polymorphisms with obesity and their relationship with plasma lipoproteins, body mass index (BMI) and hypertension.
  
  
  METHODS
  TheGSTM1andGSTT1deletion polymorphisms were analyzed by multiplex polymerase chain reaction. The lipoproteins were measured in plasma using commercially available kit and the weight, height, systolic (SBP) and diastolic (DBP) blood pressures by standard procedure of measurements.
  
  
  METHODS
  Prince Sultan Military Medical City, Riyadh Saudi Arabia.
  
  
  METHODS
  A total of 420 overweight/obese cases and 234 normal weight controls belong to young age Saudis.
  
  
  METHODS
  GSTM1/GSTT1polymorphisms may be associated with obesity.
  
  
  RESULTS
  Weight, BMI, low-density lipoprotein (LDL) and SBP were significantly higher while high-density lipoprotein (HDL) was significantly lower in cases in comparison to controls. Frequency ofGSTM1+/GSTT1- (OR = 2.70, 95% CI = 1.52-4.81,p= <0.001) andGSTM1-/GSTT1- (OR = 2.43, 95% CI = 1.15-5.15,p= 0.018) was significantly higher in cases as compared to controls. BMI and weight were significantly higher inGSTM1+/GSTT1- andGSTM1-/GSTT1- genotypes, and LDL, DBP and SBP significantly higher inGSTM1-/GSTT1- null genotype while HDL was significantly lower inGSTM1-/GSTT1+ andGSTM1-/GSTT1- genotypes in comparison toGSTM1+/GSTT1+ genotype.
  
  
  CONCLUSIONS
  TheGSTM1+/GSTT1- andGSTM1-/GSTT1- null genotypes were significantly associated with obesity and have shown relationship with obesity risk factors in cases. Hence, these genes may be associative genetic risk factor for obesity among young age Saudis.
authors.affiliation: Deparment of Cardiology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
authors.forename: Hamoud A
authors.initials: HA
authors.lastname: Almoshabek
authors.affiliation: Research Centre, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
authors.forename: Md
authors.initials: M
authors.lastname: Mustafa
authors.affiliation: Research Centre, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
authors.forename: Mohammed M
authors.initials: MM
authors.lastname: Al-Asmari
authors.affiliation: Deparment of Cardiology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
authors.forename: Tahani K
authors.initials: TK
authors.lastname: Alajmi
authors.affiliation: Research Centre, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
authors.forename: Abdulrahman K
authors.initials: AK
authors.lastname: Al-Asmari
keywords: Obesity; body mass index; genetic polymorphism; glutathione S-transferase; high-density lipoprotein; hypertension; low-density lipoprotein