title: M2 macrophages do not fly into a "RAGE".
abstract: Tumor-associated macrophages (TAMs) are key elements in orchestrating host responses inside tumor stroma. This population may undergo a polarized activation process, thus rendering a heterogeneous spectrum of phenotypes, where the classically activated type 1 macrophages (M1) and the alternative activated type 2 macrophages (M2) represent two extreme phenotypes. In this commentary, based on very recent research findings, we intend to highlight how complex could be the crosstalk among all components of tumor stroma, where the coexistence of non-natural partners may even skew the canonical responses that we can expect.
authors.affiliation: Biomedical Research Laboratories, Medicine Faculty, Catholic University of Maule, 3605 San Miguel Ave., Talca, Chile. arojasr@ucm.cl.
authors.forename: Armando
authors.initials: A
authors.lastname: Rojas
authors.affiliation: Biomedical Research Laboratories, Medicine Faculty, Catholic University of Maule, 3605 San Miguel Ave., Talca, Chile.
authors.forename: Carolina
authors.initials: C
authors.lastname: Añazco
authors.affiliation: Biomedical Research Laboratories, Medicine Faculty, Catholic University of Maule, 3605 San Miguel Ave., Talca, Chile.
authors.forename: Paulina
authors.initials: P
authors.lastname: Araya
mesh_terms: D007249:Inflammation / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D010641:Phenotype; D000067759:Receptor for Advanced Glycation End Products / Q000276:immunology; D059016:Tumor Microenvironment / Q000276:immunology
chemical_list: D000067759:Receptor for Advanced Glycation End Products
keywords: HMGB1; M2 macrophages; Macrophage polarization; Receptor of advanced glycation end products; Tumor microenvironment