title: Stability of Diazoxide in Extemporaneously Compounded Oral Suspensions.
abstract: The objective of this study was to evaluate the stability of diazoxide in extemporaneously compounded oral suspensions. Oral suspensions of diazoxide 10 mg/mL were prepared from either bulk drug or capsules dispersed in either Oral Mix or Oral Mix Sugar Free. These suspensions were stored at 5°C and 25°C/60%RH in bottles and oral syringes for a total of 90 days. At predetermined time intervals, suspensions were inspected for homogeneity, color or odor change; the pH was measured and the concentration of diazoxide was evaluated by ultraviolet detection using a stability-indicating high pressure liquid chromatography method. All preparations were demonstrated to be chemically stable for at least 90 days.
authors.affiliation: Faculté de pharmacie, Université de Montréal, Montréal, QC, Canada.
authors.forename: Mihaela
authors.initials: M
authors.lastname: Friciu
authors.affiliation: Faculté de pharmacie, Université de Montréal, Montréal, QC, Canada.
authors.forename: Sarra
authors.initials: S
authors.lastname: Zaraa
authors.affiliation: Faculté de pharmacie, Université de Montréal, Montréal, QC, Canada.
authors.forename: V Gaëlle
authors.initials: VG
authors.lastname: Roullin
authors.affiliation: Faculté de pharmacie, Université de Montréal, Montréal, QC, Canada.
authors.forename: Grégoire
authors.identifier: http://orcid.org/0000-0003-3087-2646
authors.initials: G
authors.lastname: Leclair
mesh_terms: D002214:Capsules / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D003981:Diazoxide / Q000032:analysis / Q000737:chemistry*; D004339:Drug Compounding; D004355:Drug Stability; D004356:Drug Storage; D006863:Hydrogen-Ion Concentration; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature
chemical_list: D002214:Capsules; D003981:Diazoxide