title: Non-Steroidal Anti-Inflammatory Drugs in Alzheimer's Disease and Parkinson's Disease: Reconsidering the Role of Neuroinflammation.
abstract: Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative diseases with age as the greatest risk factor. As the general population experiences extended life span, preparation for the prevention and treatment of these and other age-associated neurological diseases are warranted. Since epidemiological studies suggested that non-steroidal anti-inflammatory drug (NSAID) use decreased risk for AD and PD, increasing attention has been devoted to understanding the costs and benefits of the innate neuroinflammatory response to functional recovery following pathology onset. This review will provide a general overview on the role of neuroinflammation in these neurodegenerative diseases and an update on NSAID treatment in recent experimental animal models, epidemiological analyses, and clinical trials.
authors.affiliation: Department of Biology, Carleton College, one north college street, Northfield, MN 55057, USA. amoore@carleton.edu.
authors.forename: Amy H
authors.initials: AH
authors.lastname: Moore
authors.affiliation: Department of Biology, Carleton College, one north college street, Northfield, MN 55057, USA.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Bigbee
authors.affiliation: Department of Biology, Carleton College, one north college street, Northfield, MN 55057, USA.
authors.forename: Grace E
authors.initials: GE
authors.lastname: Boynton
authors.affiliation: Department of Biology, Carleton College, one north college street, Northfield, MN 55057, USA.
authors.forename: Colin M
authors.initials: CM
authors.lastname: Wakeham
authors.affiliation: Department of Biology, Carleton College, one north college street, Northfield, MN 55057, USA.
authors.forename: Hilary M
authors.initials: HM
authors.lastname: Rosenheim
authors.affiliation: Department of Biology, Carleton College, one north college street, Northfield, MN 55057, USA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Staral
authors.affiliation: Department of Biology, Carleton College, one north college street, Northfield, MN 55057, USA.
authors.forename: James L
authors.initials: JL
authors.lastname: Morrissey
authors.affiliation: Department of Biology, Carleton College, one north college street, Northfield, MN 55057, USA.
authors.forename: Amanda K
authors.initials: AK
authors.lastname: Hund
keywords: Alzheimer's disease; Non-steroidal anti-inflammatory drugs; Parkinson's disease; cyclooxygenase; neuroinflammation