title: Extracellular matrix components as therapeutics for spinal cord injury.
abstract: There is no treatment for people with spinal cord injury that leads to significant functional improvements. The extracellular matrix is an intricate, 3-dimensional, structural framework that defines the environment for cells in the central nervous system. The components of extracellular matrix have signaling and regulatory roles in the fate and function of neuronal and non-neuronal cells in the central nervous system. This review discusses the therapeutic potential of extracellular matrix components for spinal cord repair.
authors.affiliation: The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: aeh92@med.miami.edu.
authors.forename: Agnes E
authors.initials: AE
authors.lastname: Haggerty
authors.affiliation: The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, USA.
authors.forename: Megan M
authors.initials: MM
authors.lastname: Marlow
authors.affiliation: The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
authors.forename: Martin
authors.initials: M
authors.lastname: Oudega
mesh_terms: D000818:Animals; D001688:Biological Products / Q000627:therapeutic use*; D017690:Cell Transplantation; D005109:Extracellular Matrix / Q000737:chemistry* / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000627:therapeutic use; D006801:Humans; D013116:Spinal Cord / Q000187:drug effects* / Q000473:pathology; D013119:Spinal Cord Injuries / Q000378:metabolism / Q000628:therapy*
chemical_list: D001688:Biological Products; D016326:Extracellular Matrix Proteins
keywords: Axon growth; Central nervous system; Collagen; ECM; Fibronectin; Glial scar; Laminin; Transplantation