title: In vivo near-infrared and Cerenkov luminescence imaging of amyloid-β deposits in the brain: a fluorinated small molecule used for dual-modality imaging.
abstract: Three fluorinated (19F or18F) small molecules were evaluated as fluorescent or radiolabeled probes for Aβ deposits in the brain. In vivo near-infrared imaging suggested that probe 4c could efficiently distinguish between transgenic mice and wild-type controls. Furthermore, the in vivo Cerenkov luminescence imaging with [18F]4c showed modest differences between the two groups.
authors.affiliation: Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China. cmc@bnu.edu.cn.
authors.forename: Hualong
authors.initials: H
authors.lastname: Fu
authors.affiliation: Department of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, P. R. China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Peng
authors.affiliation: Department of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, P. R. China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Liang
authors.affiliation: Wuhan Institute for Neuroscience and Neuroengineering, South-Central University for Nationalities, Wuhan 430074, P. R. China.
authors.forename: Jiapei
authors.initials: J
authors.lastname: Dai
authors.affiliation: Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China. cmc@bnu.edu.cn.
authors.forename: Boli
authors.initials: B
authors.lastname: Liu
authors.affiliation: Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China. cmc@bnu.edu.cn.
authors.forename: Mengchao
authors.initials: M
authors.lastname: Cui