title: CRP/IL-6/IL-10 Single-Nucleotide Polymorphisms Correlate with the Susceptibility and Severity of Community-Acquired Pneumonia.
abstract: OBJECTIVE
  To explore the associations of single-nucleotide polymorphisms (SNPs) of the C-reactive protein (CRP), interleukin 6 (IL-6) and IL-10 genes with susceptibility and severity of community-acquired pneumonia (CAP).
  
  
  METHODS
  Two hundred seventy-nine CAP patients were selected for the case group and 156 healthy individuals for the control group. Polymerase chain reaction-restriction fragment length polymorphism was performed for genotyping of CRP +1059G/C (rs1800947) and +1846C/T (rs1205), IL-6 -597G/A (rs1800797) and -572C/G (rs1800796), and IL-10 -592C/A (rs1800872) and -1082G/A (rs1800896). According to CURB-65 score, the patients were assigned into the severe community-acquired pneumonia (SCAP) and non-SCAP groups.
  
  
  RESULTS
  The frequencies of the CRP +1846C/T (rs1205) (CT+TT) genotypes and T allele, the IL-6 -597G/A (rs1800797) (AA+AG) genotypes and A allele, and the IL-10 -592C/A (rs1800872) (CA+AA) genotypes and A allele were higher in the case group than the control group. Furthermore, the frequencies of the CRP +1846C/T (rs1205) (CT+TT) genotypes and T allele, the IL-6 -597G/A (rs1800797) A allele, and the IL-10 -592C/A (rs1800872) (CA+AA) genotypes and A allele were higher in the SCAP group than in the non-SCAP group.
  
  
  CONCLUSIONS
  The CRP +1846C/T (rs1205), IL-6 -597G/A (rs1800797), and IL-10 -592C/A (rs1800872) may be associated with the susceptibility and severity of CAP.
authors.affiliation: 1 Department of Family Medicine, Shuang Ho Hospital, Taipei Medical University , New Taipei City, Taiwan .
authors.forename: Shou-Chu
authors.initials: SC
authors.lastname: Chou
authors.affiliation: 2 Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine , Taoyuan, Taiwan .
authors.forename: How-Wen
authors.initials: HW
authors.lastname: Ko
authors.affiliation: 1 Department of Family Medicine, Shuang Ho Hospital, Taipei Medical University , New Taipei City, Taiwan .
authors.forename: Ying-Chin
authors.initials: YC
authors.lastname: Lin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002097:C-Reactive Protein / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D017714:Community-Acquired Infections / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics* / Q000378:metabolism; D015850:Interleukin-6 / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: C508609:IL10 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D016753:Interleukin-10; D002097:C-Reactive Protein
keywords: CRP +1059G/C; CRP +1846C/T; IL-10 −1082; IL-10 −592C/A; IL-6 −572C/G; IL-6 −597G/A; community-acquired pneumonia; single-nucleotide polymorphism; susceptibility