title: Time-course of coherence in the human basal ganglia during voluntary movements.
abstract: We are interested in characterizing how brain networks interact and communicate with each other during voluntary movements. We recorded electrical activities from the globus pallidus pars interna (GPi), subthalamic nucleus (STN) and the motor cortex during voluntary wrist movements. Seven patients with dystonia and six patients with Parkinson's disease underwent bilateral deep brain stimulation (DBS) electrode placement. Local field potentials from the DBS electrodes and scalp EEG from the electrodes placed over the motor cortices were recorded while the patients performed externally triggered and self-initiated movements. The coherence calculated between the motor cortex and STN or GPi was found to be coupled to its power in both the beta and the gamma bands. The association of coherence with power suggests that a coupling in neural activity between the basal ganglia and the motor cortex is required for the execution of voluntary movements. Finally, we propose a mathematical model involving coupled neural oscillators which provides a possible explanation for how inter-regional coupling takes place.
authors.affiliation: Department of Electrical and Computer Engineering, University of Toronto, Canada.|Institute of Biomaterials and Biomedical Engineering, University of Toronto, Canada.
authors.forename: Omid
authors.initials: O
authors.lastname: Talakoub
authors.affiliation: Toronto Western Research Institute - University Health Network, Canada.
authors.forename: Bogdan
authors.initials: B
authors.lastname: Neagu
authors.affiliation: Toronto Western Research Institute - University Health Network, Canada.
authors.forename: Kaviraja
authors.initials: K
authors.lastname: Udupa
authors.affiliation: Toronto Western Research Institute - University Health Network, Canada.
authors.forename: Eric
authors.initials: E
authors.lastname: Tsang
authors.affiliation: Toronto Western Research Institute - University Health Network, Canada.|Division of Neurology, Faculty of Medicine, University of Toronto, Canada.
authors.forename: Robert
authors.initials: R
authors.lastname: Chen
authors.affiliation: Institute of Biomaterials and Biomedical Engineering, University of Toronto, Canada.|Rehabilitation Engineering Laboratory, Toronto Rehabilitation Institute - University Health Network, Canada.
authors.forename: Milos R
authors.initials: MR
authors.lastname: Popovic
authors.affiliation: Department of Electrical and Computer Engineering, University of Toronto, Canada.|Institute of Biomaterials and Biomedical Engineering, University of Toronto, Canada.
authors.forename: Willy
authors.initials: W
authors.lastname: Wong
mesh_terms: D046690:Deep Brain Stimulation; D004421:Dystonia / Q000503:physiopathology; D004569:Electroencephalography; D005917:Globus Pallidus / Q000502:physiology*; D006801:Humans; D008959:Models, Neurological; D008962:Models, Theoretical; D009044:Motor Cortex / Q000502:physiology*; D009068:Movement; D018482:Muscle, Skeletal / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology*; D010300:Parkinson Disease / Q000503:physiopathology; D020531:Subthalamic Nucleus / Q000502:physiology*; D013997:Time Factors