title: Protection of folic acid through encapsulation in mesoporous silica particles included in fruit juices.
abstract: Folic acid (FA) is a synthetic vitamin commonly used for food fortification. However, its vulnerability to processing and storage implies loss of efficiency, which would induce over-fortification by processors to obtain a minimum dose upon consumption. Recent studies have indicated potential adverse effects of FA overdoses, and FA protection during processing and storage could lead to more accurate fortification. In addition, sustained vitamin release after consumption would help improve its metabolism. The objective of this work was to study controlled FA delivery and stability in fruit juices to reduce potential over-fortification risks by using gated mesoporous silica particles (MSPs). The obtained results indicated that FA encapsulation in MSPs significantly improved its stability and contributed to controlled release after consumption by modifying vitamin bioaccessibility. These results confirmed the suitability of MSPs as support for controlled release and protection of bioactive molecules in food matrices in different food production and storage stages.
authors.affiliation: Grupo de Investigación e Innovación Alimentaria, Departamento de Tecnología de Alimentos, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain. Electronic address: maruiri@etsia.upv.es.
authors.forename: María
authors.initials: M
authors.lastname: Ruiz-Rico
authors.affiliation: Grupo de Investigación e Innovación Alimentaria, Departamento de Tecnología de Alimentos, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain.
authors.forename: Édgar
authors.initials: É
authors.lastname: Pérez-Esteve
authors.affiliation: Grupo de Investigación e Innovación Alimentaria, Departamento de Tecnología de Alimentos, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain.
authors.forename: María J
authors.initials: MJ
authors.lastname: Lerma-García
authors.affiliation: Instituto de Interuniversitario de Investigación de Centro de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Unidad Mixta Universitat Politècnica de València - Universitat de València, Departamento de Química, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN).
authors.forename: María D
authors.initials: MD
authors.lastname: Marcos
authors.affiliation: Instituto de Interuniversitario de Investigación de Centro de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Unidad Mixta Universitat Politècnica de València - Universitat de València, Departamento de Química, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN).
authors.forename: Ramón
authors.initials: R
authors.lastname: Martínez-Máñez
authors.affiliation: Grupo de Investigación e Innovación Alimentaria, Departamento de Tecnología de Alimentos, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Barat
mesh_terms: D004355:Drug Stability; D005492:Folic Acid / Q000008:administration & dosage*; D061353:Food Storage; D005527:Food, Fortified; D000067030:Fruit and Vegetable Juices; D012822:Silicon Dioxide / Q000008:administration & dosage*
chemical_list: D012822:Silicon Dioxide; D005492:Folic Acid
keywords: Bioaccessibility modification; Folic acid; Fruit juice; Mesoporous silica particles; Stability