title: Structure and functions of the chaperone-like p97/CDC48 in plants.
abstract: The chaperone-like p97 is a member of the AAA+ ATPase enzyme family that contributes to numerous cellular activities. P97 has been broadly studied in mammals (VCP/p97) and yeasts (CDC48: Cell Division Cycle 48/p97) and numerous investigations highlighted that this protein is post-translationally regulated, is structured in homohexamer and interacts with partners and cofactors that direct it to distinct cellular signalization pathway including protein quality control and degradation, cell cycle regulation, genome stability, vesicular trafficking, autophagy and immunity.
  
  
  
  p97 is also conserved in plants (CDC48) but its functions are less understood. In the present review we intended to present the state of the art of the structure, regulation and functions of CDC48 in plants.
  
  
  
  Evidence accumulated underline that CDC48 plays a crucial role in development, cell cycle regulation and protein turnover in plants. Furthermore, its involvement in plant immunity has recently emerged and first interacting partners have been identified, shedding light on its putative cellular activities.
  
  
  
  Identification of emerging functions of CDC48 in plants opens new roads of research in immunity and provides new insights into the mechanisms of protein quality control.
authors.affiliation: Agroécologie, AgroSup Dijon, CNRS, INRA, Univ. Bourgogne Franche-Comté, F-21000 Dijon, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Bègue
authors.affiliation: Agroécologie, AgroSup Dijon, CNRS, INRA, Univ. Bourgogne Franche-Comté, F-21000 Dijon, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Jeandroz
authors.affiliation: Agroécologie, AgroSup Dijon, CNRS, INRA, Univ. Bourgogne Franche-Comté, F-21000 Dijon, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Blanchard
authors.affiliation: Agroécologie, AgroSup Dijon, CNRS, INRA, Univ. Bourgogne Franche-Comté, F-21000 Dijon, France.
authors.forename: David
authors.initials: D
authors.lastname: Wendehenne
authors.affiliation: Agroécologie, AgroSup Dijon, CNRS, INRA, Univ. Bourgogne Franche-Comté, F-21000 Dijon, France. Electronic address: claire.rosnoblet@dijon.inra.fr.
authors.forename: Claire
authors.initials: C
authors.lastname: Rosnoblet
mesh_terms: D000251:Adenosine Triphosphatases / Q000737:chemistry* / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000737:chemistry* / Q000378:metabolism*; D019143:Evolution, Molecular; D018832:Molecular Chaperones / Q000737:chemistry* / Q000378:metabolism*; D057865:Plant Immunity; D010944:Plants / Q000378:metabolism*; D013329:Structure-Activity Relationship; D000074405:Valosin Containing Protein
chemical_list: D018797:Cell Cycle Proteins; D018832:Molecular Chaperones; D000251:Adenosine Triphosphatases; D000074405:Valosin Containing Protein
keywords: Immunity; Plants; Protein turnover; p97/CDC48/VCP