title: Diastereoselective Mannich Reactions Using Fluorinated Ketones: Synthesis of Stereogenic Carbon-Fluorine Units.
abstract: A diastereoselective Mannich reaction of simple α-fluoro ketones with N-tert-butylsulfinylimines was developed. This method provides a concise route to a variety of structurally diverse α-fluoro-β-amino ketones containing fluorinated stereogenic carbon centers; good yields and high diastereoselectivities were achieved. This method uses readily accessible starting materials and has a broad substrate scope: cyclic and linear α-fluoro ketones and fluoromethyl ketones are all suitable substrates.
authors.affiliation: Department of Chemistry and Chemical Engineering, Shanghai University of Engineering Science , 333 Longteng Road, Shanghai, 201620, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Chemistry and Chemical Engineering, Shanghai University of Engineering Science , 333 Longteng Road, Shanghai, 201620, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Chemistry and Chemical Engineering, Shanghai University of Engineering Science , 333 Longteng Road, Shanghai, 201620, China.
authors.forename: Huaqi
authors.initials: H
authors.lastname: Shang
authors.affiliation: Department of Chemistry and Chemical Engineering, Shanghai University of Engineering Science , 333 Longteng Road, Shanghai, 201620, China.
authors.forename: Xiangyu
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Chemistry and Chemical Engineering, Shanghai University of Engineering Science , 333 Longteng Road, Shanghai, 201620, China.
authors.forename: Xinfeng
authors.initials: X
authors.lastname: Ren