title: Drug-nanoencapsulated PLGA microspheres prepared by emulsion electrospray with controlled release behavior.
abstract: The development of modern therapeutics has raised the requirement for controlled drug delivery system which is able to efficiently encapsulate bioactive agents and achieve their release at a desired rate satisfying the need of the practical system. In this study, two kind of aqueous model drugs with different molecule weight, Congo red and albumin from bovine serum (BSA) were nano-encapsulated in poly (dl-lactic-co-glycolic acid) (PLGA) microspheres by emulsion electrospray. In the preparation process, the aqueous phase of drugs was added into the PLGA chloroform solution to form the emulsion solution. The emulsion was then electrosprayed to fabricate drug-nanoencapsulated PLGA microspheres. The morphology of the PLGA microspheres was affected by the volume ratio of aqueous drug phase and organic PLGA phase (Vw/Vo) and the molecule weight of model drugs. Confocal laser scanning microcopy showed the nanodroplets of drug phase were scattered in the PLGA microspheres homogenously with different distribution patterns related toVw/Vo. With the increase of the volume ratio of aqueous drug phase, the number of nanodroplets increased forming continuous phase gradually that could accelerate drug release rate. Moreover, BSA showed a slower release rate from PLGA microspheres comparing to Congo red, which indicated the drug release rate could be affected by not onlyVw/Vobut also the molecule weight of model drug. In brief, the PLGA microspheres prepared using emulsion electrospray provided an efficient and simple system to achieve controlled drug release at a desired rate satisfying the need of the practices.
authors.affiliation: School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China,; State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.
authors.forename: Shenglian
authors.initials: S
authors.lastname: Yao
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Stomatology, Dalian Medical University, Dalian 116044, China.
authors.forename: Huiying
authors.initials: H
authors.lastname: Liu
authors.affiliation: Institute for Neuroscience, Capital Medical University, Beijing 100069, China.
authors.forename: Shukui
authors.initials: S
authors.lastname: Yu
authors.affiliation: State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China,; Department of Oral and Maxillofacial Surgery, School of Stomatology, Dalian Medical University, Dalian 116044, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.
authors.forename: Xiumei
authors.initials: X
authors.lastname: Wang
authors.affiliation: School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China.
authors.forename: Luning
authors.initials: L
authors.lastname: Wang
keywords: PLGA microspheres; controlled drug release; drug nanoencapsulation; emulsion electrospray