title: Access to Acyclic Z-Enediynes by Alkyne Trimerization: Cooperative Bimetallic Catalysis Using Air as the Oxidant.
abstract: Presented herein is a mild, operationally simple, mix-and-go procedure for the synthesis of acyclic trisubstituted Z-enediynes, from readily available terminal alkynes, in good yields. This method stems from a serendipitous discovery, and makes use of cooperative palladium/copper bimetallic catalysis and air as an oxidant to effect an intriguing alkyne trimerization to yield the valuable Z-enediyne moiety.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Singapore.
authors.forename: Jin Tu Danence
authors.initials: JT
authors.lastname: Lee
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Singapore. zhaoyu@nus.edu.sg.
authors.forename: Yu
authors.identifier: 0000-0002-2944-1315
authors.initials: Y
authors.lastname: Zhao
keywords: alkynes; cooperative effects; copper; palladium; trimerization