title: Efficiency of the Penumbra 5MAX ACE Reperfusion Catheter in Acute Ischemic Stroke Patients.
abstract: OBJECTIVE
  This study was performed to investigate whether the Penumbra 5MAX ACE is superior to other Penumbra systems.
  
  
  METHODS
  We performed a retrospective, single center analysis of patients with acute ischemic stroke with occlusion of the internal carotid artery or middle cerebral artery (M1 segment) who underwent endovascular therapy using a Penumbra system. The reperfusion success rate, puncture-to-revascularization time, and number of passes were assessed. Multivariate regression analysis was conducted to evaluate independent factors related to revascularization within 60 minutes. Successful revascularization was defined by a thrombolysis in cerebral infarction score ≥2b.
  
  
  RESULTS
  The Penumbra 5MAX ACE was used in 24 of the 40 patients (60%). Although the revascularization success rate was similar between patient groups (P = .229), the number of passes was significantly lower (1.5 ± .8 versus 2.6 ± 1.3, P = .006) and the puncture-to-revascularization time was shorter (50 ± 26 minutes versus 116 ± 69 minutes, P = .002) in patients treated with the Penumbra 5MAX ACE. The Penumbra 5MAX ACE was identified as an independent factor for early revascularization (odds ratio, 5.80; P = .041). Among patients with a premorbid modified Rankin Scale score of 0-1, a modified Rankin Scale score of 0-2 at 3 months was observed in 15 of the 19 patients (79%) treated with the Penumbra 5MAX ACE and in 8 of the 16 (50%) who were not (P = .072).
  
  
  CONCLUSIONS
  Acute revascularization therapy using the Penumbra 5MAX ACE can achieve rapid successful recanalization and tend to improve clinical outcomes.
authors.affiliation: Department of Neurological Science, Nippon Medical School Hospital, Tokyo, Japan. Electronic address: kentarow@nms.ac.jp.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Suzuki
authors.affiliation: Department of Neurological Science, Nippon Medical School Hospital, Tokyo, Japan.
authors.forename: Junya
authors.initials: J
authors.lastname: Aoki
authors.affiliation: Department of Neurological Science, Nippon Medical School Hospital, Tokyo, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Sakamoto
authors.affiliation: Department of Neurological Science, Nippon Medical School Hospital, Tokyo, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Kanamaru
authors.affiliation: Department of Neurological Science, Nippon Medical School Hospital, Tokyo, Japan.
authors.forename: Arata
authors.initials: A
authors.lastname: Abe
authors.affiliation: Department of Neurological Science, Nippon Medical School Hospital, Tokyo, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Suda
authors.affiliation: Department of Neurological Science, Nippon Medical School Hospital, Tokyo, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Okubo
authors.affiliation: Department of Neurological Science, Nippon Medical School Hospital, Tokyo, Japan.
authors.forename: Kazumi
authors.initials: K
authors.lastname: Kimura
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D057785:Catheters; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004185:Disability Evaluation; D004867:Equipment Design; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D011677:Punctures; D020127:Recovery of Function; D012189:Retrospective Studies; D020521:Stroke / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D015912:Thrombolytic Therapy / Q000009:adverse effects / Q000295:instrumentation*; D013997:Time Factors; D061665:Time-to-Treatment; D014041:Tokyo; D016896:Treatment Outcome
keywords: Penumbra 5MAX ACE; acute ischemic stroke; endovascular therapy; revascularization