title: Insight into the role of TSLP in inflammatory bowel diseases.
abstract: Proinflammatory cytokines are thought to modulate pathogeneses of various inflammatory bowel diseases (IBDs). Thymic stromal lymphopoietin (TSLP), which has been studied in various allergic diseases such as asthma, atopic dermatitis (AD) and eosinophilic esophagitis (EoE), has been less considered to be involved in IBDs. However, mucosal dendritic cells (DCs) induced by various cytokines including TSLP were reported to cause polarization of T cell toward Th2 response, the differentiation of regulatory T-cell (Treg), and secretion of IgA by B cells. In this review, we discuss the concept that decreased TSLP has the potential to accelerate the development of Th1 response dominant diseases such as the Crohn's disease (CD) while increased TSLP has the potential to lead to a development of Th2 cell dominant diseases such the ulcerative colitis (UC). To examine TSLP's role as a potential determining factor for differentiating UC and CD, we analyzed the effects of other genes regulated by TSLP in regards to the UC and CD pathogeneses using data from online open access resources such as NetPath, GeneMania, and the String database. Our findings indicate that TSLP is a key mediator in the pathogenesis of IBDs and that further studies are needed to evaluate its role.
authors.affiliation: Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Jae Hyon
authors.initials: JH
authors.lastname: Park
authors.affiliation: Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Dong Yeon
authors.initials: DY
authors.lastname: Jeong
authors.affiliation: Inserm U954 and Department of Gastroenterology, Nancy University Hospital, Université de Lorraine, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Peyrin-Biroulet
authors.affiliation: Luton & Dunstable University Hospital NHS Foundation Trust, Luton, United Kingdom.
authors.forename: Michael
authors.initials: M
authors.lastname: Eisenhut
authors.affiliation: Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea. Electronic address: shinji@yuhs.ac.
authors.forename: Jae Il
authors.initials: JI
authors.lastname: Shin
mesh_terms: D000818:Animals; D016207:Cytokines / Q000502:physiology*; D003713:Dendritic Cells / Q000187:drug effects; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000276:immunology / Q000378:metabolism*; D018121:Receptors, Cytokine / Q000378:metabolism; D015398:Signal Transduction; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D000094632:Thymic Stromal Lymphopoietin
chemical_list: C498762:CRLF2 protein, human; D016207:Cytokines; D018121:Receptors, Cytokine; D000094632:Thymic Stromal Lymphopoietin
keywords: Gene-to-gene network; Immuno-pathogenesis; Inflammatory bowel disease; Protein-to-protein network; Thymic stromal lymphopoietin