title: Chiroptical Asymmetric Reaction Screening via Multicomponent Self-Assembly.
abstract: Self-assembly of a stereodynamic phosphine ligand, Pd(II), and a chiral amine, amino alcohol, or amino acid generates characteristic UV and CD signals that can be used for quantitative stereochemical analysis of the bound substrate. A robust mix-and-measure chiroptical sensing protocol has been developed and used to determine the absolute configuration, ee, and yield of an amine produced by Ir-catalyzed asymmetric hydrogenation of an iminium salt. The analysis requires only 1 mg of the crude reaction mixture and minimizes cost, labor, time, and waste.
authors.affiliation: Department of Chemistry, Georgetown University , Washington, D.C. 20057, United States.
authors.forename: Zeus A
authors.initials: ZA
authors.lastname: De Los Santos
authors.affiliation: Department of Chemistry, Georgetown University , Washington, D.C. 20057, United States.
authors.forename: Christian
authors.initials: C
authors.lastname: Wolf