title: Association of rs10757274 and rs2383206 Polymorphisms on 9p21 locus with Coronary Artery Disease in Turkish Population.
abstract: OBJECTIVE
  Genetic predisposition is an important risk factor for coronary artery disease (CAD). In this study, we aimed to evaluate the impact of rs10757274 and rs2383206 polymorphisms in chromosome 9p21 on presence and severity of CAD in a Turkish population.
  
  
  METHODS
  A total of 646 patients who underwent coronary angiography were included in this study. Coronary vessel score and Gensini score were calculated to assess the angiographic severity of CAD. Alleles of AA, AG, and GG were determined for rs10757274 (polymorphism-1) and rs2383206 (polymorphism-2) polymorphisms located in chromosome 9p21 from the blood samples.
  
  
  RESULTS
  There was a significant difference between the alleles in polymorphism-1 in the presence of coronary artery disease (38.9% in AA, 48.0% in GG and 56.4% in AG, p=0.017). However, there was no difference between the alleles in polymorphism-2. According to vessel scores, there was a significant difference between the alleles in polymorphism-1 (AA 0.71±1.04, GG 0.88±1.07, AG 1.06±1.12, p=0.018). In polymorphism-2, vessel scores did not show a difference between the alleles. In polymorphism-1, there was a significant difference in Gensini score (p=0.041). Gensini scores did not differ between the alleles in polymorphism-2 (p>0.05 for all). In multivariate analyses, none of the alleles was an independent factor for presence of CAD.
  
  
  CONCLUSIONS
  The presence of rs10757274 polymorphism including AG allele in chromosome 9p21 was related to CAD. However, this relationship was not independent of other cardiovascular risk factors.
authors.affiliation: Department of Cardiology, School of Medicine, Gazi University, Ankara, Turkey.
authors.forename: Çağrı
authors.initials: Ç
authors.lastname: Yayla
authors.affiliation: Department of Cardiology, School of Medicine, Baskent University, Ankara, Turkey.
authors.forename: Kaan
authors.initials: K
authors.lastname: Okyay
authors.affiliation: Department of Medical Biology and Genetic, School of Medicine, Gazi University, Ankara, Turkey.
authors.forename: Akın
authors.initials: A
authors.lastname: Yılmaz
authors.affiliation: Department of Cardiology, School of Medicine, Gazi University, Ankara, Turkey.
authors.forename: Asife
authors.initials: A
authors.lastname: Şahinarslan
authors.affiliation: Department of Medical Biology and Genetic, School of Medicine, Gazi University, Ankara, Turkey.
authors.forename: Atiye Seda
authors.initials: AS
authors.lastname: Yar Sağlam
authors.affiliation: Department of Cardiology, School of Medicine, Gazi University, Ankara, Turkey.
authors.forename: Azmi
authors.initials: A
authors.lastname: Eyiol
authors.affiliation: Department of Cardiology, School of Medicine, Gazi University, Ankara, Turkey.
authors.forename: Hasan Ata
authors.initials: HA
authors.lastname: Bolayır
authors.affiliation: Department of Cardiology, School of Medicine, Gazi University, Ankara, Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Sezenöz
authors.affiliation: Department of Medical Biology and Genetic, School of Medicine, Gazi University, Ankara, Turkey.
authors.forename: Sevda
authors.initials: S
authors.lastname: Menevşe
authors.affiliation: Department of Cardiology, School of Medicine, Gazi University, Ankara, Turkey.
authors.forename: Atiye
authors.initials: A
authors.lastname: Çengel
keywords: Atherosclerosis; Genetics; Polymorphism