title: Reversible Facial Hyperpigmentation Associated With Vitamin B12 Deficiency.
abstract: Vitamin B12 (cobalamin) deficiency is common in developing countries. Its dermatologic manifestations include hair and nail changes and glossitis. Cases of generalized hyperpigmentation associated with vitamin B12 deficiency have rarely been reported. Localized hyperpigmentation is less frequently described, affecting palms, soles, and flexural areas. We report a rare case of reversible melasma-like cutaneous hyperpigmentation associated with pernicious anemia and discuss the possible mechanisms of this association.
authors.affiliation: 1 Department of Dermatology, Charles Nicolle Hospital, University of Tunis El Manar, Tunis, Tunisia.
authors.forename: Leeda
authors.initials: L
authors.lastname: Tayem
authors.affiliation: 1 Department of Dermatology, Charles Nicolle Hospital, University of Tunis El Manar, Tunis, Tunisia.
authors.forename: Noureddine
authors.initials: N
authors.lastname: Litaiem
authors.affiliation: 1 Department of Dermatology, Charles Nicolle Hospital, University of Tunis El Manar, Tunis, Tunisia.
authors.forename: Mariem
authors.initials: M
authors.lastname: Jones
authors.affiliation: 1 Department of Dermatology, Charles Nicolle Hospital, University of Tunis El Manar, Tunis, Tunisia.
authors.forename: Faten
authors.initials: F
authors.lastname: Zeglaoui
mesh_terms: D000752:Anemia, Pernicious / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D007273:Injections, Intramuscular; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D014805:Vitamin B 12 / Q000008:administration & dosage
chemical_list: D014805:Vitamin B 12
keywords: cobalamin; hyperpigmentation; pernicious anemia; vitamin B12; vitamin B12 deficiency