title: COSMIC: High-Resolution Cancer Genetics Using the Catalogue of Somatic Mutations in Cancer.
abstract: COSMIC (http://cancer.sanger.ac.uk) is an expert-curated database of somatic mutations in human cancer. Broad and comprehensive in scope, recent releases in 2016 describe over 4 million coding mutations across all human cancer disease types. Mutations are annotated across the entire genome, but expert curation is focused on over 400 key cancer genes. Now encompassing the majority of molecular mutation mechanisms in oncogenetics, COSMIC additionally describes 10 million non-coding mutations, 1 million copy-number aberrations, 9 million gene-expression variants, and almost 8 million differentially methylated CpGs. This information combines a consistent interpretation of the data from the major cancer genome consortia and cancer genome literature with exhaustive hand curation of over 22,000 gene-specific literature publications. This unit describes the graphical Web site in detail; alternative protocols overview other ways the entire database can be accessed, analyzed, and downloaded. © 2016 by John Wiley & Sons, Inc.
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
authors.forename: S A
authors.initials: SA
authors.lastname: Forbes
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
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authors.initials: D
authors.lastname: Beare
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
authors.forename: N
authors.initials: N
authors.lastname: Bindal
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
authors.forename: S
authors.initials: S
authors.lastname: Bamford
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
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authors.initials: S
authors.lastname: Ward
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
authors.forename: C G
authors.initials: CG
authors.lastname: Cole
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
authors.forename: M
authors.initials: M
authors.lastname: Jia
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
authors.forename: C
authors.initials: C
authors.lastname: Kok
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
authors.forename: H
authors.initials: H
authors.lastname: Boutselakis
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
authors.forename: T
authors.initials: T
authors.lastname: De
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
authors.forename: Z
authors.initials: Z
authors.lastname: Sondka
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
authors.forename: L
authors.initials: L
authors.lastname: Ponting
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
authors.forename: R
authors.initials: R
authors.lastname: Stefancsik
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
authors.forename: B
authors.initials: B
authors.lastname: Harsha
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
authors.forename: J
authors.initials: J
authors.lastname: Tate
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
authors.forename: E
authors.initials: E
authors.lastname: Dawson
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
authors.forename: S
authors.initials: S
authors.lastname: Thompson
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
authors.forename: H
authors.initials: H
authors.lastname: Jubb
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
authors.forename: P J
authors.initials: PJ
authors.lastname: Campbell
mesh_terms: D030541:Databases, Genetic; D006801:Humans; D058977:Molecular Sequence Annotation; D009154:Mutation / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D009857:Oncogenes / Q000235:genetics*
keywords: COSMIC; cancer; database; genetics; genomics; mutation; somatic