title: Novel Multitarget Hybrid Compounds for the Treatment of Alzheimer's Disease.
abstract: Alzheimer's disease (AD) is the most prevalent among the aging diseases known as neurodegenerative disorders. Drug design programs over the last two decades were mainly based on the cholinergic, the amyloid or the tau hypothesis. However, none of the new drugs have a real impact on the outcome of the disease. The complex nature of AD has led to new approaches for drug development programs, the multitarget drug design hypothesis. Based on this hypothesis, the generation of multitarget hybrid compounds from previously known active molecules has been one of the most widely used to obtain new candidates for the future treatment of AD. Here, we summarize recent developments based on the hybridization hypothesis to obtain a potential clinical candidate for AD.
authors.affiliation: Instituto Teofilo Hernando y Departamento de Farmacologia y Terapeutica, Facultad de Medicina. Universidad Autonoma de Madrid, 28029 Madrid,. Spain.
authors.forename: Patrycja
authors.initials: P
authors.lastname: Michalska
authors.affiliation: Instituto Teofilo Hernando y Departamento de Farmacologia y Terapeutica, Facultad de Medicina. Universidad Autonoma de Madrid, 28029 Madrid,. Spain.
authors.forename: Izaskun
authors.initials: I
authors.lastname: Buendia
authors.affiliation: Instituto Gulbenkian de Ciencia, Rua da Quinta Grande, 2780-156 Oeiras,. Portugal.
authors.forename: Laura
authors.initials: L
authors.lastname: Del Barrio
authors.affiliation: Instituto Teofilo Hernando, Departamento de Farmacologia y Terapeutica, Facultad de Medicina, UAM; C/ Arzobispo Morcillo, 4, 28029, Madrid,. Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Leon
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D002800:Cholinesterase Inhibitors; D018696:Neuroprotective Agents; D000110:Acetylcholinesterase
keywords: Alzheimer's disease; Antioxidants; Drug design; Dual AChE
  Inhibitors; Emerging targets for AD; Hybrid compounds; Multitarget drugs; Nrf2-EpRE inducers.