title: Genome-wide chromatin and gene expression profiling during memory formation and maintenance in adult mice.
abstract: Recent evidence suggests that the formation and maintenance of memory requires epigenetic changes. In an effort to understand the spatio-temporal extent of learning and memory-related epigenetic changes we have charted genome-wide histone and DNA methylation profiles, in two different brain regions, two cell types, and three time-points, before and after learning. In this data descriptor we provide detailed information on data generation, give insights into the rationale of experiments, highlight necessary steps to assess data quality, offer guidelines for future use of the data and supply ready-to-use code to replicate the analysis results. The data provides a blueprint of the gene regulatory network underlying short- and long-term memory formation and maintenance. This 'healthy' gene regulatory network of learning can now be compared to changes in neurological or psychiatric diseases, providing mechanistic insights into brain disorders and highlighting potential therapeutic avenues.
authors.affiliation: Research Group for Computational Systems Biology, German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Straße 3A, 37075, Göttingen, Germany.
authors.forename: Tonatiuh Pena
authors.initials: TP
authors.lastname: Centeno
authors.affiliation: Research Group for Computational Systems Biology, German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Straße 3A, 37075, Göttingen, Germany.
authors.forename: Orr
authors.initials: O
authors.lastname: Shomroni
authors.affiliation: Research Group for Computational Systems Biology, German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Straße 3A, 37075, Göttingen, Germany.
authors.forename: Magali
authors.initials: M
authors.lastname: Hennion
authors.affiliation: Research Group for Epigenetic Mechanisms in Dementia, German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Straße 3A, 37075, Göttingen, Germany.
authors.forename: Rashi
authors.initials: R
authors.lastname: Halder
authors.affiliation: Research Group for Computational Systems Biology, German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Straße 3A, 37075, Göttingen, Germany.
authors.forename: Ramon
authors.initials: R
authors.lastname: Vidal
authors.affiliation: Research Group for Computational Systems Biology, German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Straße 3A, 37075, Göttingen, Germany.
authors.forename: Raza-Ur
authors.initials: RU
authors.lastname: Rahman
authors.affiliation: Research Group for Computational Systems Biology, German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Straße 3A, 37075, Göttingen, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Bonn
mesh_terms: D000818:Animals; D002843:Chromatin / Q000235:genetics*; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D020869:Gene Expression Profiling; D055106:Genome-Wide Association Study; D006657:Histones / Q000235:genetics; D057567:Memory, Long-Term; D051379:Mice
chemical_list: D002843:Chromatin; D006657:Histones