title: The Fruit Hull ofGleditsia sinensisEnhances the Anti-Tumor Effect ofcis-Diammine Dichloridoplatinum II (Cisplatin).
abstract: Lung cancer has substantial mortality worldwide, and chemotherapy is a routine regimen for the treatment of patients with lung cancer, despite undesirable effects such as drug resistance and chemotoxicity. Here, given a possible antitumor effect of the fruit hull ofGleditsia sinensis(FGS), we tested whether FGS enhances the effectiveness ofcis-diammine dichloridoplatinum (II) (CDDP), a chemotherapeutic drug. We found that CDDP, when administered with FGS, significantly decreased the viability and increased the apoptosis and cell cycle arrest of Lewis lung carcinoma (LLC) cells, which were associated with the increase of p21 and decreases of cyclin D1 and CDK4. Concordantly, when combined with FGS, CDDP significantly reduced the volume and weight of tumors derived from LLC subcutaneously injected into C57BL/6 mice, with concomitant increases of phosphor-p53 and p21 in tumor tissue. Together, these results show that FGS could enhance the antitumor activity of CDDP, suggesting that FGS can be used as a complementary measure to enhance the efficacy of a chemotherapeutic agent such as CDDP.
authors.affiliation: School of Korean Medicine, Pusan National University, Yangsan 50621, Republic of Korea.
authors.forename: Kyun Ha
authors.identifier: 0000-0002-6568-703X
authors.initials: KH
authors.lastname: Kim
authors.affiliation: School of Korean Medicine, Pusan National University, Yangsan 50621, Republic of Korea; Department of Internal Medicine, Korean Medicine Hospital of Pusan National University, Yangsan 50621, Republic of Korea.
authors.forename: Chang-Woo
authors.initials: CW
authors.lastname: Han
authors.affiliation: Lung Cancer Clinic, Pulmonary Medicine Center, Pusan National University Yangsan Hospital, Yangsan 50621, Republic of Korea.
authors.forename: Seong Hoon
authors.initials: SH
authors.lastname: Yoon
authors.affiliation: Lung Cancer Clinic, Pulmonary Medicine Center, Pusan National University Yangsan Hospital, Yangsan 50621, Republic of Korea; Department of Internal Medicine, School of Medicine, Pusan National University, Yangsan 50621, Republic of Korea.
authors.forename: Yun Seong
authors.initials: YS
authors.lastname: Kim
authors.affiliation: Department of Acupuncture and Moxibustion, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
authors.forename: Jong-In
authors.initials: JI
authors.lastname: Kim
authors.affiliation: School of Korean Medicine, Pusan National University, Yangsan 50621, Republic of Korea.
authors.forename: Myungsoo
authors.identifier: 0000-0002-5417-1732
authors.initials: M
authors.lastname: Joo
authors.affiliation: School of Korean Medicine, Pusan National University, Yangsan 50621, Republic of Korea; Department of Internal Medicine, Korean Medicine Hospital of Pusan National University, Yangsan 50621, Republic of Korea.
authors.forename: Jun-Yong
authors.identifier: 0000-0002-2854-3862
authors.initials: JY
authors.lastname: Choi