title: Stabilized pyrrolyl iodonium salts and metal-free oxidative cross-coupling.
abstract: Pyrrole-aryl derivatives are important due to their unique biological activities in medicinal chemistry. We now report a new oxidative biaryl coupling for pyrroles and indoles toward various arenes using a hypervalent iodine reagent and an appropriate stabilizer for pyrrolyl iodonium intermediates. The reactions readily provide a variety of desired coupling products in good yields.
authors.affiliation: Ritsumeikan University, College of Pharmaceutical Sciences, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Morimoto
authors.affiliation: Ritsumeikan University, College of Pharmaceutical Sciences, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Ohnishi
authors.affiliation: Ritsumeikan University, College of Pharmaceutical Sciences, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan.
authors.forename: Daichi
authors.initials: D
authors.lastname: Koseki
authors.affiliation: Ritsumeikan University, Research Organization of Science and Technology, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan. kita@ph.ritsumei.ac.jp.
authors.forename: Akira
authors.initials: A
authors.lastname: Nakamura
authors.affiliation: Ritsumeikan University, College of Pharmaceutical Sciences, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan.
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Dohi
authors.affiliation: Ritsumeikan University, Research Organization of Science and Technology, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan. kita@ph.ritsumei.ac.jp.
authors.forename: Yasuyuki
authors.identifier: http://orcid.org/0000-0003-0324-5807
authors.initials: Y
authors.lastname: Kita