title: Phenolics from Lagotis brevituba Maxim.
abstract: A phytochemical investigation on Lagotis brevituba led to the isolation and characterisation of 11 phenolic compounds: p-hydroxy-benzoic acid 1, methyl 3,4-dihydroxybenzoate 2, vanillic acid 3, protocatechuic acid 4, caffeic acid 5, glucose ester of (E)-ferulic acid 6, p-coumaric acid 7, vanillin 8, diosmetin-7-O-β-d-glucoside 9, chrysoeriol 10 and luteolin 11. Their structures were elucidated using spectroscopic methods and by comparison with data in the literature. Compounds 1-6 were first obtained from the genus Lagotis, and compounds 1-9 were isolated from L. brevituba for the first time. Compound 4 and 11 displayed remarkable antioxidant activities against DPPH radical (IC50= 5.60 ± 0.09, 27.5 ± 0.06 mg/L, respectively), which were superior to positive control rutin. And compound 11 was also superior to rutin in ABTS assay (IC50= 2.04 ± 0.13 mg/L).
authors.affiliation: a Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology , Chinese Academy of Sciences , Xining , P.R. China.|b College of life science , University of Chinese Academy of Sciences , Beijing , P.R. China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Yuan
authors.affiliation: a Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology , Chinese Academy of Sciences , Xining , P.R. China.|b College of life science , University of Chinese Academy of Sciences , Beijing , P.R. China.
authors.forename: Huaixiu
authors.initials: H
authors.lastname: Wen
authors.affiliation: a Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology , Chinese Academy of Sciences , Xining , P.R. China.|b College of life science , University of Chinese Academy of Sciences , Beijing , P.R. China.
authors.forename: Yulei
authors.initials: Y
authors.lastname: Cui
authors.affiliation: a Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology , Chinese Academy of Sciences , Xining , P.R. China.|b College of life science , University of Chinese Academy of Sciences , Beijing , P.R. China.
authors.forename: Minxia
authors.initials: M
authors.lastname: Fan
authors.affiliation: a Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology , Chinese Academy of Sciences , Xining , P.R. China.
authors.forename: Zenggen
authors.initials: Z
authors.lastname: Liu
authors.affiliation: a Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology , Chinese Academy of Sciences , Xining , P.R. China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Mei
authors.affiliation: a Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology , Chinese Academy of Sciences , Xining , P.R. China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Shao
authors.affiliation: c Shanghai Institute of Materia Medica , Chinese Academy of Sciences , Shanghai , P.R. China.
authors.forename: Yiping
authors.initials: Y
authors.lastname: Wang
authors.affiliation: a Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology , Chinese Academy of Sciences , Xining , P.R. China.
authors.forename: Yanduo
authors.initials: Y
authors.lastname: Tao
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification; D002109:Caffeic Acids / Q000737:chemistry / Q000302:isolation & purification; D003373:Coumaric Acids / Q000737:chemistry / Q000302:isolation & purification; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification; D062385:Hydroxybenzoates / Q000737:chemistry / Q000302:isolation & purification; D047311:Luteolin / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification; D010936:Plant Extracts / Q000032:analysis / Q000737:chemistry; D000068377:Plantaginaceae / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: D000975:Antioxidants; D002109:Caffeic Acids; D003373:Coumaric Acids; D005419:Flavonoids; D005960:Glucosides; D062385:Hydroxybenzoates; D010636:Phenols; D010936:Plant Extracts; C009091:protocatechuic acid; C004999:ferulic acid; C000600341:methyl 3,4-dihydroxybenzoate; D047311:Luteolin; C039602:diosmetin; C040048:caffeic acid
keywords: Lagotis brevituba; phenolics; spectroscopic methods