title: Association between -1082G/A, -819C/T, and -592C/A genetic polymorphisms in IL-10 and risk of type 2 diabetes mellitus in a Chinese population.
abstract: Type 2 diabetes mellitus is the most common form of endocrine disease in humans; genetic factors are known to contribute to the development of this disease. In this case-control study, we investigated the relationship between the -1082G/A, -819C/T, and -592C/A polymorphisms in interleukin 10 (IL-10) and the pathogenesis of type 2 diabetes mellitus in a Chinese population. Patients with type 2 diabetes mellitus (N = 228) and control subjects (N = 240) were recruited from the Department of Endocrinology at the People's Hospital of Linyi City, between September 2013 and April 2015. The IL-10 -1082G/A, -819C/T, and -592C/A polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism. Multivariate logistic regression analyses revealed that patients carrying the AA genotype of IL-10 -592C/A were at a higher risk of developing type 2 diabetes mellitus compared to those carrying the CC genotype [adjusted odds ratio (OR) = 1.74; 95% confidence interval (CI) = 1.03-2.95]. In addition, individuals carrying the A allele of IL-10 -592C/A showed a 1.34-fold higher risk of developing type 2 diabetes mellitus compared to those carrying the C allele (adjusted OR = 1.34; 95%CI = 1.03- 1.75). There was no significant correlation between the IL-10 -1082G/ A and -819C/T polymorphisms and risk of type 2 diabetes mellitus. In conclusion, this study shows that the -1082G/A polymorphism of IL-10 contributes to the onset of type 2 diabetes mellitus, and may be considered a biomarker for early screening of type 2 diabetes mellitus in the Chinese population studied here.
authors.affiliation: Department of Endocrinology, People's Hospital of Linyi, Linyi, China.
authors.forename: Q Y
authors.initials: QY
authors.lastname: Dong
authors.affiliation: Department of Endocrinology, People's Hospital of Linyi, Linyi, China.
authors.forename: X M
authors.initials: XM
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, People's Hospital of Linyi, Linyi, China.
authors.forename: C G
authors.initials: CG
authors.lastname: Liang
authors.affiliation: Department of Endocrinology, People's Hospital of Linyi, Linyi, China.
authors.forename: W H
authors.initials: WH
authors.lastname: Du
authors.affiliation: Department of Endocrinology, People's Hospital of Linyi, Linyi, China.
authors.forename: Y L
authors.initials: YL
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, People's Hospital of Linyi, Linyi, China.
authors.forename: W X
authors.initials: WX
authors.lastname: Li
authors.affiliation: Department of Endocrinology, People's Hospital of Linyi, Linyi, China guanqigaogao@163.com.
authors.forename: G Q
authors.initials: GQ
authors.lastname: Gao
mesh_terms: D000328:Adult; D017668:Age of Onset; D000483:Alleles; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis* / Q000208:ethnology / Q000235:genetics*; D042241:Early Diagnosis; D005260:Female; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D012307:Risk Factors
chemical_list: D015415:Biomarkers; C508609:IL10 protein, human; D016753:Interleukin-10