title: MPTP Induces Systemic Parkinsonism in Middle-Aged Cynomolgus Monkeys: Clinical Evolution and Outcomes.
abstract: In this study, we developed a systemic PD model in middle-aged cynomolgus monkeys using individualized low-dose MPTP, to explore effective indicators for the early prediction of clinical outcomes. MPTP was not stopped until the animals showed typical PD motor symptoms on days 10 to 13 after MPTP administration when the Kurlan score reached 10; this abrogated the differences in individual susceptibility to MPTP. The clinical symptoms persisted, peaking on days 3 to 12 after MPTP withdrawal (rapid progress stage), and then the Kurlan score plateaued. A Kurlan score at the end of the rapid progress stage >15 reflected stable or slowly-progressive PD, while a score <15 indicated spontaneous recovery. The entire clinical evolution and outcome of the systemic PD model was characterized in this study, thus providing options for therapeutic and translational research.
authors.affiliation: Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.|Key Laboratory on Parkinson's Disease, Beijing, 100053, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Yue
authors.affiliation: Department of Pathology, Guilin Medical College, Guilin, 541001, China.
authors.forename: Sien
authors.initials: S
authors.lastname: Zeng
authors.affiliation: Wincon TheraCells Biotechnologies Co., Ltd., Nanning, 530003, China.
authors.forename: Rongping
authors.initials: R
authors.lastname: Tang
authors.affiliation: Wincon TheraCells Biotechnologies Co., Ltd., Nanning, 530003, China.
authors.forename: Guoxian
authors.initials: G
authors.lastname: Tao
authors.affiliation: Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China. pbchan@hotmail.com.|Key Laboratory on Parkinson's Disease, Beijing, 100053, China. pbchan@hotmail.com.
authors.forename: Piu
authors.initials: P
authors.lastname: Chan
mesh_terms: D000818:Animals; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D004195:Disease Models, Animal; D005260:Female; D007980:Levodopa / Q000627:therapeutic use*; D020267:MPTP Poisoning / Q000188:drug therapy* / Q000503:physiopathology*; D008252:Macaca fascicularis; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome; D014741:Video Recording
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa
keywords: Clinical evolution; Cynomolgus monkeys; MPTP; Motor behavior; Parkinson’s disease; Spontaneous recovery