title: [Total pancreatectomy for pancreatic cancer].
abstract: OBJECTIVE
  to determine the indications and to evaluate early and long-term outcomes of total pancreatectomy for pancreatic cancer.
  
  
  METHODS
  Treatment of 29 patients who underwent one- and two-stage pancreatectomy for different malignancies was analyzed.
  
  
  RESULTS
  Median of surgery duration and intraoperative blood loss was 280 min and 2200 ml respectively. Postoperative complications were observed in 9 (31%) patients. There were 2 (6.9%) deaths. 1- and 3-year overall actual survival was 61% and 16% respectively in case of ductal adenocarcinoma. Median was 18 months. Patients after surgery for primary multiple lesion (cancer of pancreatic body-tail and major duodenal papilla), pancreatic metastases of renal cancer, mucinous cystadenoma and neuroendocrine cancer are still alive. Follow-up periods are 4, 49, 49 and 65 months respectively.
  
  
  CONCLUSIONS
  Total pancreatectomy is difficult intervention followed by severe metabolic disorders. However it can improve long-term survival with acceptable incidence of postoperative complications and quality of life if clear indications for surgery are present.
authors.affiliation: Blokhin Russian Cancer Research Center, Moscow, Russia.
authors.forename: Yu I
authors.initials: YI
authors.lastname: Patyutko
authors.affiliation: Blokhin Russian Cancer Research Center, Moscow, Russia.
authors.forename: N E
authors.initials: NE
authors.lastname: Kudashkin
authors.affiliation: Blokhin Russian Cancer Research Center, Moscow, Russia.
authors.forename: A G
authors.initials: AG
authors.lastname: Kotel'nikov
authors.affiliation: Blokhin Russian Cancer Research Center, Moscow, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Chistyakova
mesh_terms: D005260:Female; D006801:Humans; D000069451:Long Term Adverse Effects / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control / Q000523:psychology; D008297:Male; D008659:Metabolic Diseases / Q000175:diagnosis / Q000209:etiology; D008875:Middle Aged; D009031:Moscow / Q000453:epidemiology; D009367:Neoplasm Staging; D010180:Pancreatectomy / Q000009:adverse effects / Q000379:methods; D010190:Pancreatic Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery; D011183:Postoperative Complications / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control / Q000523:psychology; D011788:Quality of Life; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome