title: Comparative effects of piperine and simvastatin in fat accumulation and antioxidative status in high fat-induced hyperlipidemic rats.
abstract: The present study investigated the comparative effects of piperine (PIP) - the active ingredient of black and long peppers - and simvastatin (SIM) on hepatic steatosis in hyperlipidemic rats. Male Wistar rats were fed a cholesterol mixture daily by intragastric gavage for 8 weeks. Piperine was given by oral gavage 8 h after cholesterol feeding. The animals were divided into 4 groups: control, high fat (HF), high fat plus 40 mg PIP/kg, and high fat plus 2 mg SIM/kg. At the end of the treatment, liver cholesterol, triglyceride, thiobaribituric reacting substances, superoxide dismutase (SOD), serum aminotransferase (AST), and alanine transferase (ALT) were measured. The result demonstrated that PIP and SIM significantly reduced the accumulation of cholesterol, triglyceride, and lipid peroxidation in the liver, while elevation of SOD was observed. The activities of AST and ALT significantly decreased in PIP when compared with the HF group. Our in vitro study of pancreatic lipase also showed the inhibitory effect of PIP higher than 30% at 5 mmol/L. These results demonstrate that PIP has beneficial effects in the treatment and (or) prevention of fat accumulation in the liver and that this mechanism is due to the inhibition of pancreatic lipase and the improvement of oxidative status.
authors.affiliation: Department of Physiology, Faculty of Medical Science, Naresuan University, 99 Moo 9, Tahpoh, Muang, Phitsanulok 65000, Thailand.|Department of Physiology, Faculty of Medical Science, Naresuan University, 99 Moo 9, Tahpoh, Muang, Phitsanulok 65000, Thailand.
authors.forename: Sakara
authors.initials: S
authors.lastname: Tunsophon
authors.affiliation: Department of Physiology, Faculty of Medical Science, Naresuan University, 99 Moo 9, Tahpoh, Muang, Phitsanulok 65000, Thailand.|Department of Physiology, Faculty of Medical Science, Naresuan University, 99 Moo 9, Tahpoh, Muang, Phitsanulok 65000, Thailand.
authors.forename: Krongkarn
authors.initials: K
authors.lastname: Chootip
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000470:Alkaloids / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D052117:Benzodioxoles / Q000494:pharmacology / Q000627:therapeutic use*; D059305:Diet, High-Fat / Q000009:adverse effects*; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects; D005234:Fatty Liver / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D006949:Hyperlipidemias / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D010880:Piperidines / Q000494:pharmacology / Q000627:therapeutic use*; D053284:Polyunsaturated Alkamides / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D019821:Simvastatin / Q000627:therapeutic use*
chemical_list: D000470:Alkaloids; D000975:Antioxidants; D052117:Benzodioxoles; D004041:Dietary Fats; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D019821:Simvastatin; C008922:piperine
keywords: antioxidant; antioxydant; dyslipidemia; dyslipidémie; hepatic steatosis; piperine; pipérine; simvastatin; simvastatine; stéatose hépatique