title: Pomegranate peel extract attenuates oxidative stress by decreasing coronary angiotensin-converting enzyme (ACE) activity in hypertensive female rats.
abstract: Based on the antioxidant properties of pomegranate, this study was designed to investigate the effects of pomegranate peel extract on damage associated with hypertension and aging in a spontaneously hypertensive rat (SHR) model. The influence of pomegranate consumption was examined on systolic blood pressure (SBP), angiotensin-converting enzyme (ACE) coronary activity, oxidative stress, and vascular morphology. Four- or 28-wk-old SHR model rats were treated for 30 d, with terminal experimental animal age being 8 and 32 wk, respectively, with either pomegranate extract (SHR-PG) or filtered water (SHR). Data showed significant reduction in SBP and coronary ACE activity in both age groups. The levels of superoxide anion, a measure of oxidative stress, were significantly lower in animals in the SHR-PG group compared to SHR alone. Coronary morphology demonstrated total increases in vascular wall areas were in the SHR group, and pomegranate peel extract diminished this effect. Pomegranate peel extract consumption conferred protection against hypertension in the SHR model. This finding was demonstrated by marked reduction in coronary ACE activity, oxidative stress, and vascular remodelling. In addition, treatment was able to reduce SBP in both groups. Evidence indicates that the use of pomegranate peel extract may prove beneficial in alleviating coronary heart disease.
authors.affiliation: a Department of Physiological Sciences , Federal University of Espirito Santo , Vitoria , Espirito Santo , Brazil.
authors.forename: Roger L
authors.initials: RL
authors.lastname: Dos Santos
authors.affiliation: a Department of Physiological Sciences , Federal University of Espirito Santo , Vitoria , Espirito Santo , Brazil.
authors.forename: Lais O
authors.initials: LO
authors.lastname: Dellacqua
authors.affiliation: a Department of Physiological Sciences , Federal University of Espirito Santo , Vitoria , Espirito Santo , Brazil.
authors.forename: Nathalie T B
authors.initials: NT
authors.lastname: Delgado
authors.affiliation: a Department of Physiological Sciences , Federal University of Espirito Santo , Vitoria , Espirito Santo , Brazil.
authors.forename: Wender N
authors.initials: WN
authors.lastname: Rouver
authors.affiliation: a Department of Physiological Sciences , Federal University of Espirito Santo , Vitoria , Espirito Santo , Brazil.
authors.forename: Priscila L
authors.initials: PL
authors.lastname: Podratz
authors.affiliation: b Department of Physiology and Biophysics , Federal University of Minas Gerais , Belo Horizonte , Minas Gerais , Brazil.
authors.forename: Leandro C F
authors.initials: LC
authors.lastname: Lima
authors.affiliation: c Department of Biophysics , Federal University of Rio de Janeiro , Rio de Janeiro , Brazil.
authors.forename: Mariela P C
authors.initials: MP
authors.lastname: Piccin
authors.affiliation: a Department of Physiological Sciences , Federal University of Espirito Santo , Vitoria , Espirito Santo , Brazil.
authors.forename: Silvana S
authors.initials: SS
authors.lastname: Meyrelles
authors.affiliation: a Department of Physiological Sciences , Federal University of Espirito Santo , Vitoria , Espirito Santo , Brazil.
authors.forename: Helder
authors.initials: H
authors.lastname: Mauad
authors.affiliation: d Department of Morphology , Federal University of Espirito Santo , Vitoria , Espirito Santo , Brazil.
authors.forename: Jones B
authors.initials: JB
authors.lastname: Graceli
authors.affiliation: a Department of Physiological Sciences , Federal University of Espirito Santo , Vitoria , Espirito Santo , Brazil.
authors.forename: Margareth R
authors.initials: MR
authors.lastname: Moyses
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D005260:Female; D005638:Fruit / Q000737:chemistry; D006973:Hypertension / Q000503:physiopathology*; D029561:Lythraceae / Q000737:chemistry*; D018384:Oxidative Stress / Q000187:drug effects*; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D066253:Vascular Remodeling
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D007703:Peptidyl-Dipeptidase A