title: Post-traumatic stress influences local and remote functional connectivity: a resting-state functional magnetic resonance imaging study.
abstract: Post-traumatic stress disorder (PTSD) is associated with alterations in regional brain activation and remote functional connectivity (FC) in limbic and prefrontal cortex. However, little is known about local FC changes following a traumatic event. Resting-state functional magnetic resonance images were collected for typhoon survivors with (n = 27) and without PTSD (n = 33), and healthy controls (n = 30). Local FC was examined by calculating regional homogeneity (ReHo), and remote FC was investigated between regions showing significant ReHo group differences. The PTSD group showed ReHo changes in multiple regions, including the amygdala, parahippocampal gyrus, and prefrontal cortex relative to both control groups. Compared with healthy controls, typhoon survivors had increased ReHo in the insula/inferior frontal gyrus, middle and dorsal anterior cingulate cortex (MCC/dACC), as well as enhanced negative FC between the MCC/dACC and posterior cingulate cortex (PCC)/precuneus. The typhoon-exposed control group exhibited higher ReHo in the PCC/precuneus than the PTSD and healthy control groups. Furthermore, positive correlations were found between PTSD symptom severity and ReHo in several regions. Post-traumatic stress can influence local and remote FC, irrespective of PTSD diagnosis. Future studies are needed to validate the findings and to determine whether the alterations represent pre-existing or acquired deficits.
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, No.305 Zhongshan East Road, Nanjing, Jiangsu Province, 210002, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Ke
authors.affiliation: Department of Radiology, People's Hospital of Hainan Province, Haikou, 570311, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, No.305 Zhongshan East Road, Nanjing, Jiangsu Province, 210002, China.
authors.forename: Rongfeng
authors.initials: R
authors.lastname: Qi
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, No.305 Zhongshan East Road, Nanjing, Jiangsu Province, 210002, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xu
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, No.305 Zhongshan East Road, Nanjing, Jiangsu Province, 210002, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhong
authors.affiliation: Mental Health Institute, the Second Xiangya Hospital, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, No.139 Middle Renmin Road, Changsha, Hunan Province, 410011, China.
authors.forename: Lida
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Radiology, People's Hospital of Hainan Province, Haikou, 570311, China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Li
authors.affiliation: Mental Health Institute, the Second Xiangya Hospital, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, No.139 Middle Renmin Road, Changsha, Hunan Province, 410011, China. zhangli-mail@163.com.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, No.305 Zhongshan East Road, Nanjing, Jiangsu Province, 210002, China. cjr.luguangming@vip.163.com.
authors.forename: Guangming
authors.initials: G
authors.lastname: Lu
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001931:Brain Mapping; D003430:Cross-Sectional Studies; D055867:Cyclonic Storms; D004190:Disasters; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000503:physiopathology; D012146:Rest; D013313:Stress Disorders, Post-Traumatic / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*
keywords: Functional connectivity; Functional magnetic resonance imaging; Post-traumatic stress disorder; Regional homogeneity; Trauma