title: Growing Up with Type 1 Narcolepsy: Its Anthropometric and Endocrine Features.
abstract: To evaluate the effect of type 1 narcolepsy (NT1) on anthropometric and endocrine features in childhood/adolescence, focusing on patterns and correlates of weight, pubertal development, and growth in treated and untreated patients.
  
  
  
  We collected anthropometric (height, weight, body mass index (BMI) z-scores), pubertal, metabolic, and endocrine data from 72 NT1 patients at diagnosis and all available premorbid anthropometric parameters of patients from their pediatric files (n = 30). New measurements at 1-y reassessment in patients undergoing different treatments were compared with baseline data.
  
  
  
  We detected a high prevalence of overweight (29.2%), obesity (25%), metabolic syndrome (18.8%), and precocious puberty (16.1%), but no signs of linear growth alterations at diagnosis. According to anthropometric records, weight gain started soon after NT1 onset. At 1-y follow-up reassessment, sodium oxybate treatment was associated with a significant BMI z-score reduction (-1.29 ± 0.30, p < 0.0005) after adjusting for baseline age, sex, sleepiness, and BMI.
  
  
  
  NT1 onset in children/adolescents is associated with rapid weight gain up to overweight/obesity and precocious puberty without affecting growth. In our study, sodium oxybate treatment resulted in a significant weight reduction in NT1 overweight/obese patients at 1-y follow-up.
authors.affiliation: Pediatric Unit, S. Orsola-Malpighi University Hospital, Bologna, Italy.
authors.forename: Virginia
authors.initials: V
authors.lastname: Ponziani
authors.affiliation: Pediatric Unit, S. Orsola-Malpighi University Hospital, Bologna, Italy.
authors.forename: Monia
authors.initials: M
authors.lastname: Gennari
authors.affiliation: Department of Biomedical and NeuroMotor Sciences, University of Bologna, Italy.|IRCCS Institute of Neurological Sciences, Bellaria Hospital, Bologna, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Pizza
authors.affiliation: Pediatric Endocrinology Unit, Center for Rare Endocrine Diseases, S. Orsola-Malpighi University Hospital, Bologna, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Balsamo
authors.affiliation: Pediatric Unit, S. Orsola-Malpighi University Hospital, Bologna, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Bernardi
authors.affiliation: Department of Biomedical and NeuroMotor Sciences, University of Bologna, Italy.|IRCCS Institute of Neurological Sciences, Bellaria Hospital, Bologna, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Plazzi
mesh_terms: D000886:Anthropometry; D015992:Body Mass Index; D001835:Body Weight; D002648:Child; D002657:Child Development / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000503:physiopathology; D009290:Narcolepsy / Q000150:complications* / Q000503:physiopathology; D050177:Overweight / Q000150:complications* / Q000503:physiopathology; D011627:Puberty
keywords: growth; narcolepsy type 1; obesity; precocious puberty; sodium oxybate