title: Serum 25-hydroxyvitamin D3is associated with disease status in patients with neuromyelitis optica spectrum disorders in south China.
abstract: Here, we investigated the relationship between serum 25-hydroxyvitamin D3(25[OH]D3) levels and neuromyelitis optica spectrum disorder (NMOSD). Patients with NMOSD had lower 25(OH)D3levels than healthy people, with lower levels in patients in the acute phase than those in remission. An inverse correlation was found between 25(OH)D3and Expanded Disability Status Scale scores of patients during attacks. Higher serum 25(OH)D3levels were associated with greater amelioration of symptoms during corticosteroid therapy. These results indicate that decreased vitamin D may be involved in NMOSD pathogenesis, and that 25(OH)D3serum levels may reflect the severity of NMOSD in the acute phase.
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, No 600 Tianhe Road, Guangzhou City, China.
authors.forename: Yilong
authors.initials: Y
authors.lastname: Shan
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, No 600 Tianhe Road, Guangzhou City, China.
authors.forename: Sha
authors.initials: S
authors.lastname: Tan
authors.affiliation: Department of Neurology, The Fifth Affiliated Hospital of Sun Yat-sen University, No 52 Meihuadong Road, Zhuhai City, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Clinical Laboratory, The Third Affiliated Hospital of Sun Yat-sen University, No 600 Tianhe Road, Guangzhou City, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, No 600 Tianhe Road, Guangzhou City, China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, No 600 Tianhe Road, Guangzhou City, China.
authors.forename: Yuge
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, No 600 Tianhe Road, Guangzhou City, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Cai
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, No 600 Tianhe Road, Guangzhou City, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Qiu
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, No 600 Tianhe Road, Guangzhou City, China.
authors.forename: Xueqiang
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, No 600 Tianhe Road, Guangzhou City, China. Electronic address: lzq1828@163.com.
authors.forename: Zhengqi
authors.initials: Z
authors.lastname: Lu
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002112:Calcifediol / Q000097:blood*; D002681:China / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009471:Neuromyelitis Optica / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D015415:Biomarkers; D002112:Calcifediol
keywords: 25-Hydroxyvitamin D3; Acute phase; Expanded Disability Status Scale; Neuromyelitis optica spectrum disorder