title: Effect of the premedication with oral clonidine on surgical comfort in patients undergoing fess due to advanced nasal polyposis: A randomized double blind clinical trial.
abstract: OBJECTıVE: The objective of this randomized double blind study was to evaluate effect of the premedication with oral clonidine on blood pressure, cleaning of surgical site and bleeding in the ESS performed due to advanced NP.
  
  
  METHODS
  A total of 52 patients who underwent functional endoscopic sinus surgery (FESS) due to Kennedy grade 4 nasal polyposis (NP) were included. Patients were randomized into two groups. Group 1 (n=26) received 0.2mg oral clonodine one hour before the operation in addition to standard anesthesia procedure. Group 2 (n=26) was administered standard anesthesia procedure alone. The amount of bleeding during surgery, cleaning of surgical site and surgeon's satisfaction were evaluated in comparison between the groups.
  
  
  RESULTS
  The amount of bleeding and mean arterial pressure were significantly lower in the Group 1 compared to the Group 2. The cleaning of surgical site was found to be significantly better and surgeon's satisfaction significantly higher in the Group 1 than in the Group 2. Systolic, diastolic and mean arterial pressures during surgery were significantly lower in the Group 1 compared to the Group 2.
  
  
  CONCLUSIONS
  Premedication with oral clonidine provides a clearer view of surgical site, reduces the amount of bleeding and significantly increases surgeon's satisfaction during the operation in FESS performed due to NP. Premedication with oral clonidine is a safe, inexpensive and effective methods in order to increase the surgical success and comfort and reduce complications in the FESS surgery.
authors.affiliation: Department of Otorhinolaryngology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
authors.forename: Selahattin
authors.initials: S
authors.lastname: Tugrul
authors.affiliation: Department of Otorhinolaryngology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey. Electronic address: dr.remzidogan@gmail.com.
authors.forename: Remzi
authors.initials: R
authors.lastname: Dogan
authors.affiliation: Department of Otorhinolaryngology, Alaca State Hospital, Corum, Turkey.
authors.forename: Erol
authors.initials: E
authors.lastname: Senturk
authors.affiliation: Department of Otorhinolaryngology, Koc University, İstanbul, Turkey.
authors.forename: Ilker
authors.initials: I
authors.lastname: Kocak
authors.affiliation: Department of Otorhinolaryngology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
authors.forename: Seda
authors.initials: S
authors.lastname: Sezen
authors.affiliation: Department of Anesthesiology and Reanimation, Acıbadem Taksim Hospital, Istanbul, Turkey.
authors.forename: Mefkur
authors.initials: M
authors.lastname: Bakan
authors.affiliation: Department of Otorhinolaryngology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
authors.forename: Orhan
authors.initials: O
authors.lastname: Ozturan
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D016063:Blood Loss, Surgical; D003000:Clonidine / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000601:surgery*; D057605:Natural Orifice Endoscopic Surgery / Q000009:adverse effects*; D017063:Outcome Assessment, Health Care; D011292:Premedication
chemical_list: D000959:Antihypertensive Agents; D003000:Clonidine