title: Acid-Sensing Ion Channels and Pain.
abstract: Pathophysiological conditions such as inflammation, ischemia, infection and tissue injury can all evoke pain, and each is accompanied by local acidosis. Acid sensing ion channels (ASICs) are proton-gated cation channels expressed in both central and peripheral nervous systems. Increasing evidence suggests that ASICs represent essential sensors for tissue acidosis-related pain. This review provides an update on the role of ASICs in pain sensation and discusses their therapeutic potential for pain management.
authors.affiliation: Department of Physiology, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536-0298, USA. qgu2@email.uky.edu.
authors.forename: Qihai
authors.initials: Q
authors.lastname: Gu
authors.affiliation: Department of Physiology, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536-0298, USA. lylee@uky.edu.
authors.forename: Lu-Yuan
authors.initials: LY
authors.lastname: Lee
keywords: acid sensing ion channel; acidosis; inflammation; nociceptor; pain