title: Coupling of shear-circumferential stress pulses investigation through stress phase angle in FSI models of stenotic artery using experimental data.
abstract: Many cardiovascular diseases are closely associated with hemodynamic parameters. The main purpose of this study is mimicking a physiological blood flow in stenotic arteries to provide an understanding of hemodynamic parameters. An experimental setup was designed to produce original pulsatile flow and measure pressure pulse waves through a compliant tube. Moreover, a numerical model considering fluid-solid interaction was developed to investigate wall shear stress and circumferential stress waves, based on the results of the experiments. Results described elevated mean pressure by increasing stenosis severity especially at the critical obstacle of 50 %, which the pressure rose significantly and raised up by 10 mm Hg that may cause damage in endothelial cells. Increasing in stenosis severity led to: more negative wall shear stress and more oscillation of shear stress at the post-stenotic region and also more absolute value of angular phase difference between wall shear stress and circumferential stress waves at the stenotic throat. All of the aforementioned parameters determinant the endothelial cell pathology in predication of potential sites of progression of atherosclerotic plaques. Therefore, results can be applied in study of plaque growth and mechanisms of arterial remodeling in atherosclerosis.
authors.affiliation: Mechanical and Aerospace Engineering Department, Oklahoma State University, Stillwater, OK, USA.
authors.forename: Milad
authors.initials: M
authors.lastname: Samaee
authors.affiliation: Cardiovascular Engineering Lab., Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran. tafazoli@aut.ac.ir.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Tafazzoli-Shadpour
authors.affiliation: Department of Biomedical Engineering, University of California, Irvine, CA, USA.
authors.forename: Hamed
authors.initials: H
authors.lastname: Alavi
mesh_terms: D000818:Animals; D001158:Arteries / Q000503:physiopathology*; D050197:Atherosclerosis / Q000503:physiopathology*; D001783:Blood Flow Velocity; D001794:Blood Pressure; D003198:Computer Simulation; D006801:Humans; D008955:Models, Cardiovascular; D009991:Oscillometry / Q000379:methods; D011673:Pulsatile Flow; D063177:Pulse Wave Analysis / Q000379:methods; D033081:Shear Strength; D013314:Stress, Mechanical
keywords: Artery stenosis; Fluid–structure interaction; Oscillatory shear index; Pulsatile flow; Stress phase angle