title: Regioselective Synthesis of Dihydrothiophenes and Thiophenes via the Rhodium-Catalyzed Transannulation of 1,2,3-Thiadiazoles with Alkenes.
abstract: A method for the regioselective synthesis of a wide range of dihydrothiophenes was developed from the rhodium-catalyzed transannulation of 1,2,3-thiadiazoles with aliphatic, aromatic, and heteroaromatic alkenes. Tandem rhodium-catalyzed transannulation of 1,2,3-thiadiazoles with alkenes followed by 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) oxidation was also demonstrated for the one-pot regioselective synthesis of various thiophenes. Advantages of the present method include a broad substrate scope, wide functional group compatibility, and high regioselectivity.
authors.affiliation: Department of Chemistry, Kangwon National University , Chuncheon 24341, Republic of Korea.
authors.forename: Jeong-Yu
authors.initials: JY
authors.lastname: Son
authors.affiliation: Department of Chemistry, Kangwon National University , Chuncheon 24341, Republic of Korea.
authors.forename: Jonghye
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Chemistry, Kangwon National University , Chuncheon 24341, Republic of Korea.
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Han
authors.affiliation: Analysis Research Division Daegu Center, Korea Basic Science Institute , Daegu 41566, Republic of Korea.
authors.forename: Sung Hong
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Chemistry, Kangwon National University , Chuncheon 24341, Republic of Korea.
authors.forename: Phil Ho
authors.initials: PH
authors.lastname: Lee