title: Optical Coherence Tomography for Brain Imaging and Developmental Biology.
abstract: Optical coherence tomography (OCT) is a promising research tool for brain imaging and developmental biology. Serving as a three-dimensional optical biopsy technique, OCT provides volumetric reconstruction of brain tissues and embryonic structures with micrometer resolution and video rate imaging speed. Functional OCT enables label-free monitoring of hemodynamic and metabolic changes in the brainin vitroandin vivoin animal models. Due to its non-invasiveness nature, OCT enables longitudinal imaging of developing specimensin vivowithout potential damage from surgical operation, tissue fixation and processing, and staining with exogenous contrast agents. In this paper, various OCT applications in brain imaging and developmental biology are reviewed, with a particular focus on imaging heart development. In addition, we report findings on the effects of a circadian gene (Clock) and high-fat-diet on heart development inDrosophila melanogaster. These findings contribute to our understanding of the fundamental mechanisms connecting circadian genes and obesity to heart development and cardiac diseases.
authors.affiliation: Department of Electrical and Computer Engineering, Center for Photonics and Nanoelectronics, and Bioengineering Program, Lehigh University, Bethlehem, PA, USA, 18015.
authors.forename: Jing
authors.initials: J
authors.lastname: Men
authors.affiliation: Department of Electrical and Computer Engineering, Center for Photonics and Nanoelectronics, and Bioengineering Program, Lehigh University, Bethlehem, PA, USA, 18015.
authors.forename: Yongyang
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Electrical and Computer Engineering, Center for Photonics and Nanoelectronics, and Bioengineering Program, Lehigh University, Bethlehem, PA, USA, 18015.
authors.forename: Jitendra
authors.initials: J
authors.lastname: Solanki
authors.affiliation: Department of Electrical and Computer Engineering, Center for Photonics and Nanoelectronics, and Bioengineering Program, Lehigh University, Bethlehem, PA, USA, 18015.
authors.forename: Xianxu
authors.initials: X
authors.lastname: Zeng
authors.affiliation: Department of Electrical and Computer Engineering, Center for Photonics and Nanoelectronics, and Bioengineering Program, Lehigh University, Bethlehem, PA, USA, 18015.
authors.forename: Aneesh
authors.initials: A
authors.lastname: Alex
authors.affiliation: Department of Electrical and Computer Engineering, Center for Photonics and Nanoelectronics, and Bioengineering Program, Lehigh University, Bethlehem, PA, USA, 18015.
authors.forename: Jason
authors.initials: J
authors.lastname: Jerwick
authors.affiliation: Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China, 450000.
authors.forename: Zhan
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, 02129.
authors.forename: Rudolph E
authors.initials: RE
authors.lastname: Tanzi
authors.affiliation: Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, 02129.
authors.forename: Airong
authors.initials: A
authors.lastname: Li
authors.affiliation: Department of Electrical and Computer Engineering, Center for Photonics and Nanoelectronics, and Bioengineering Program, Lehigh University, Bethlehem, PA, USA, 18015.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhou
keywords: Biological systems; Biomedical optical imaging; Brain; Cardiovascular system and Optical tomography