title: Improvement in degradability of 58s glass scaffolds by ZnO and β-TCP modification.
abstract: 58s bioactive glass shows great potential for bone defects repair. However, at early repairing stage, the degradation rate of 58s glass is too fast due to the fast ion-exchange. At later repairing stage, the degradation rate of 58s glass is too slow due to the high dense mineral layer. In this work, Zinc oxide (ZnO) and β-tricalcium phosphate (β-TCP) were introduced into 58s glass bone scaffolds to improve the degradability. The results showed that ZnO could decrease the degradation rate and promote the stability of 58s glass at early repairing stage. Moreover, the presence of β-TCP appeared to increase the degradation rate at a later stage of repairing. Furthermore, in vitro biocompatibility study, carried out using human osteoblast-like cells (MG63), demonstrated that ZnO and β-TCP enhanced cell attachment and proliferation. The study provided a reference for further research in bone tissue engineering.
authors.affiliation: a State Key Laboratory of High Performance Complex Manufacturing, Central South University , Changsha , P.R. China.|c Shenzhen Research Institute, Central South University , Shenzhen , P.R. China.
authors.forename: Cijun
authors.initials: C
authors.lastname: Shuai
authors.affiliation: a State Key Laboratory of High Performance Complex Manufacturing, Central South University , Changsha , P.R. China.
authors.forename: Yiyuan
authors.initials: Y
authors.lastname: Cao
authors.affiliation: d School of Basic Medical Science, Central South University , Changsha , P.R. China.
authors.forename: Gao
authors.initials: G
authors.lastname: Dan
authors.affiliation: a State Key Laboratory of High Performance Complex Manufacturing, Central South University , Changsha , P.R. China.
authors.forename: Chengde
authors.initials: C
authors.lastname: Gao
authors.affiliation: a State Key Laboratory of High Performance Complex Manufacturing, Central South University , Changsha , P.R. China.
authors.forename: Pei
authors.initials: P
authors.lastname: Feng
authors.affiliation: b College of Chemistry, Xiangtan University , Xiangtan , P.R. China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wu
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D002130:Calcium Phosphates / Q000737:chemistry*; D002460:Cell Line; D005898:Glass / Q000737:chemistry*; D006801:Humans; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry*; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate; C448994:bioactive glass 58S; D015034:Zinc Oxide
keywords: 58s glass; ZnO; bone tissue engineering; degradability; β-TCP