title: A comparative study of efficacy and safety of febuxostat and allopurinol in pyrazinamide-induced hyperuricemic tubercular patients.
abstract: OBJECTIVE
  To compare the efficacy and safety of febuxostat and allopurinol in pyrazinamide (PZA)-induced hyperuricemia in patients taking antitubercular therapy (ATT).
  
  
  METHODS
  This randomized controlled study was conducted at a tertiary care teaching institute of Rajasthan in all the sputum-positive tubercular patients aged between 18 and 65 years of either sex. Serum uric acid level was monitored at 0th, 2nd, 4th, 6th, and 8thweek of ATT. Patients whose uric acid level was found to be increased at 2ndweek were finally recruited in the study. Ninety patients who developed hyperuricemia due to ATT were divided randomly into three groups (Group A - febuxostat, Group B - allopurinol, and Group C - control) of thirty patients each. Mean serum uric acid levels were calculated at all the weeks in all the groups, and serum uric acid levels were compared by applying student'st-test and ANOVA.
  
  
  RESULTS
  Mean serum uric acid level decreased from 10.698 mg/dl (at 2ndweek) to 7.846 mg/dl (at 8thweek) in Group A and from 11.34 mg/dl (at 2ndweek) to 7.280 mg/dl (at 8thweek) in Group B. Numbers of adverse events encountered across both the treatment groups were same with both the drugs.
  
  
  CONCLUSIONS
  Allopurinol and febuxostat were equally efficacious in lowering PZA induced raised serum uric acid level in tubercular patients, and it was possible to continue ATT without withdrawing PZA.
authors.affiliation: Department of Pharmacology, Geetanjali Medical College, Udaipur, Rajasthan, India.
authors.forename: Meenu
authors.initials: M
authors.lastname: Pichholiya
authors.affiliation: Department of Pharmacology, Geetanjali Medical College, Udaipur, Rajasthan, India.
authors.forename: Arvind Kumar
authors.initials: AK
authors.lastname: Yadav
authors.affiliation: Department of Respiratory Medicine, Geetanjali Medical College, Udaipur, Rajasthan, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Luhadia
authors.affiliation: Department of Pharmacology, Geetanjali Medical College, Udaipur, Rajasthan, India.
authors.forename: Jameela
authors.initials: J
authors.lastname: Tahashildar
authors.affiliation: Department of Pharmacology, Geetanjali Medical College, Udaipur, Rajasthan, India.
authors.forename: M L
authors.initials: ML
authors.lastname: Aseri
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000493:Allopurinol / Q000627:therapeutic use*; D000995:Antitubercular Agents / Q000009:adverse effects*; D000069465:Febuxostat / Q000627:therapeutic use*; D005260:Female; D006074:Gout Suppressants / Q000627:therapeutic use*; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011718:Pyrazinamide / Q000009:adverse effects*; D016896:Treatment Outcome; D014527:Uric Acid / Q000097:blood; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents; D006074:Gout Suppressants; D000069465:Febuxostat; D014527:Uric Acid; D011718:Pyrazinamide; D000493:Allopurinol
keywords: Allopurinol; antitubercular therapy; febuxostat; hyperuricemia