title: Diagnostic Evaluation in Aspirin-Exacerbated Respiratory Disease.
abstract: Aspirin-exacerbated respiratory disease (AERD) is a distinct clinical condition characterized by chronic sinusitis with nasal polyps, asthma, and hypersensitivity reactions to nonsteroidal anti-inflammatory drugs (NSAIDs). Distinguishing AERD from other forms of chronic sinusitis, asthma, and NSAID reactivity has important clinical implications for management. The clinical history is helpful, but not adequate for confirming the diagnosis of AERD, in most cases. Diagnostic provocation challenge remains the only way to confirm or exclude the diagnosis of AERD. This article discusses the utility of the clinical history and the current evidence regarding measures that optimize the safety of performing diagnostic NSAID provocation challenges.
authors.affiliation: Department of Allergy, Asthma, and Immunology, Bend Memorial Clinic, 815 Southwest Bond Street, Bend, OR 97702, USA; School of Medicine, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. Electronic address: awilliams@bmctotalcare.com.
authors.forename: Adam N
authors.initials: AN
authors.lastname: Williams
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D001985:Bronchial Provocation Tests; D006801:Humans; D009299:Nasal Provocation Tests; D010641:Phenotype; D012129:Respiratory Function Tests; D012140:Respiratory Tract Diseases / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D012680:Sensitivity and Specificity
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin
keywords: Aspirin-exacerbated respiratory disease; Asthma; Chronic rhinosinusitis with nasal polyps; Diagnosis; Intranasal ketorolac; Lysine-aspirin; NSAID hypersensitivity; Oral aspirin challenge