title: Neural correlates of three types of negative life events during angry face processing in adolescents.
abstract: Negative life events (NLE) contribute to anxiety and depression disorders, but their relationship with brain functioning in adolescence has rarely been studied. We hypothesized that neural response to social threat would relate to NLE in the frontal-limbic emotional regions. Participants (N = 685) were drawn from the Imagen database of 14-year-old community adolescents recruited in schools. They underwent functional MRI while viewing angry and neutral faces, as a probe to neural response to social threat. Lifetime NLEs were assessed using the 'distress', 'family' and 'accident' subscales from a life event dimensional questionnaire. Relationships between NLE subscale scores and neural response were investigated. Links of NLE subscales scores with anxiety or depression outcomes at the age of 16 years were also investigated. Lifetime 'distress' positively correlated with ventral-lateral orbitofrontal and temporal cortex activations during angry face processing. 'Distress' scores correlated with the probabilities of meeting criteria for Generalized Anxiety Disorder or Major Depressive Disorder at the age of 16 years. Lifetime 'family' and 'accident' scores did not relate with neural response or follow-up conditions, however. Thus, different types of NLEs differentially predicted neural responses to threat during adolescence, and differentially predicted a de novo internalizing condition 2 years later. The deleterious effect of self-referential NLEs is suggested.
authors.affiliation: INSERM, UMR 1000, Research Unit NeuroImaging and Psychiatry, Service Hospitalier Frédéric Joliot, Orsay, University Paris-Sud, University Paris Saclay, Orsay, and Maison De Solenn, University Paris Descartes, Paris, France.
authors.forename: Fanny
authors.initials: F
authors.lastname: Gollier-Briant
authors.affiliation: INSERM, UMR 1000, Research Unit NeuroImaging and Psychiatry, Service Hospitalier Frédéric Joliot, Orsay, University Paris-Sud, University Paris Saclay, Orsay, and Maison De Solenn, University Paris Descartes, Paris, France.|AP-HP, Department of Adolescent Psychopathology and Medicine, Maison De Solenn, Cochin Hospital, Paris, France.
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Paillère-Martinot
authors.affiliation: INSERM, UMR 1000, Research Unit NeuroImaging and Psychiatry, Service Hospitalier Frédéric Joliot, Orsay, University Paris-Sud, University Paris Saclay, Orsay, and Maison De Solenn, University Paris Descartes, Paris, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Lemaitre
authors.affiliation: INSERM, UMR 1000, Research Unit NeuroImaging and Psychiatry, Service Hospitalier Frédéric Joliot, Orsay, University Paris-Sud, University Paris Saclay, Orsay, and Maison De Solenn, University Paris Descartes, Paris, France.
authors.forename: Ruben
authors.initials: R
authors.lastname: Miranda
authors.affiliation: INSERM, UMR 1000, Research Unit NeuroImaging and Psychiatry, Service Hospitalier Frédéric Joliot, Orsay, University Paris-Sud, University Paris Saclay, Orsay, and Maison De Solenn, University Paris Descartes, Paris, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Vulser
authors.affiliation: King's College London Institute of Psychiatry, Psychology & Neuroscience, London, United Kingdom.
authors.forename: Robert
authors.initials: R
authors.lastname: Goodman
authors.affiliation: University of Tampere, Medical School, Tampere, Finland.
authors.forename: Jani
authors.initials: J
authors.lastname: Penttilä
authors.affiliation: Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
authors.forename: Maren
authors.initials: M
authors.lastname: Struve
authors.affiliation: Universitaetsklinikum Hamburg Eppendorf, Hamburg, Germany.
authors.forename: Tahmine
authors.initials: T
authors.lastname: Fadai
authors.affiliation: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany.
authors.forename: Viola
authors.initials: V
authors.lastname: Kappel
authors.affiliation: Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
authors.forename: Luise
authors.initials: L
authors.lastname: Poustka
authors.affiliation: Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Grimmer
authors.affiliation: Universitaetsklinikum Hamburg Eppendorf, Hamburg, Germany.
authors.forename: Uli
authors.initials: U
authors.lastname: Bromberg
authors.affiliation: CHU Ste Justine, Department of Psychiatry, Université De Montréal, Montréal, QC, Canada.
authors.forename: Patricia
authors.initials: P
authors.lastname: Conrod
authors.affiliation: Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Banaschewski
authors.affiliation: King's College London Institute of Psychiatry, Psychology & Neuroscience, London, United Kingdom.
authors.forename: Gareth J
authors.initials: GJ
authors.lastname: Barker
authors.affiliation: Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
authors.forename: Arun L W
authors.initials: AL
authors.lastname: Bokde
authors.affiliation: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Büchel
authors.affiliation: Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
authors.forename: Herta
authors.initials: H
authors.lastname: Flor
authors.affiliation: Department of Psychiatry and Psychotherapy, Campus CharitéMitte, Charité - Universitätsmedizin, Berlin, Germany.
authors.forename: Juergen
authors.initials: J
authors.lastname: Gallinat
authors.affiliation: Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.|Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA.
authors.forename: Hugh
authors.initials: H
authors.lastname: Garavan
authors.affiliation: Department of Psychiatry and Psychotherapy, Campus CharitéMitte, Charité - Universitätsmedizin, Berlin, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Heinz
authors.affiliation: School of Psychology, University of Nottingham, Nottingham, United Kingdom.
authors.forename: Claire
authors.initials: C
authors.lastname: Lawrence
authors.affiliation: Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
authors.forename: Karl
authors.initials: K
authors.lastname: Mann
authors.affiliation: Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.|Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
authors.forename: Frauke
authors.initials: F
authors.lastname: Nees
authors.affiliation: Rotman Research Institute.
authors.forename: Tomas
authors.initials: T
authors.lastname: Paus
authors.affiliation: Department of Physiology and Nutritional Sciences, the Hospital for Sick Children, University of Toronto, Toronto, Canada.
authors.forename: Zdenka
authors.initials: Z
authors.lastname: Pausova
authors.affiliation: Neurospin, Commissariat à L'Energie Atomique Et Aux Energies Alternatives, Saclay, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Frouin
authors.affiliation: Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
authors.forename: Marcella
authors.initials: M
authors.lastname: Rietschel
authors.affiliation: Psychology and Behavioural and Clinical neuroscience Institute, University of Cambridge, Cambridge, United Kingdom.
authors.forename: Trevor W
authors.initials: TW
authors.lastname: Robbins
authors.affiliation: Department of Psychiatry and Neuroimaging Center, Technische Universit㲠Dresden, Germany.
authors.forename: Michael N
authors.initials: MN
authors.lastname: Smolka
authors.affiliation: King's College London Institute of Psychiatry, Psychology & Neuroscience, London, United Kingdom.|MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, London, United Kingdom.
authors.forename: Gunter
authors.initials: G
authors.lastname: Schumann
authors.affiliation: INSERM, UMR 1000, Research Unit NeuroImaging and Psychiatry, Service Hospitalier Frédéric Joliot, Orsay, University Paris-Sud, University Paris Saclay, Orsay, and Maison De Solenn, University Paris Descartes, Paris, France jean-luc.martinot@inserm.fr.|CENIR Centre de Neuroimagerie de Recherche at Institute of Brain and Spine, Pitié - Salpétrière, Paris, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Martinot
authors.affiliation: INSERM, UMR 1000, Research Unit NeuroImaging and Psychiatry, Service Hospitalier Frédéric Joliot, Orsay, University Paris-Sud, University Paris Saclay, Orsay, and Maison De Solenn, University Paris Descartes, Paris, France.|Psychiatry Department, Orsay Hospital, Orsay, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Artiges
mesh_terms: D000293:Adolescent; D000786:Anger / Q000502:physiology*; D001007:Anxiety / Q000000981:diagnostic imaging / Q000503:physiopathology; D001008:Anxiety Disorders / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003863:Depression / Q000000981:diagnostic imaging / Q000503:physiopathology; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005149:Facial Expression; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008016:Life Change Events; D008279:Magnetic Resonance Imaging; D008297:Male
keywords: adolescence; anxiety; depression; fMRI; negative life events; social threat