title: Effectiveness of Amlexanox and Adcortyl for the treatment of recurrent aphthous ulcers.
abstract: BACKGROUND
  Recurrent aphthous stomatitis (RAS) is a common condition that affects approximately 20% of the general population. The ulcers can interfere with speech and eating and cause significant pain and discomfort. This study aimed to evaluate the efficacy of Amlexanox and Adcortyl in the treatment of aphthous ulcers.
  
  
  METHODS
  In this randomized double blind clinical trial with sequential patient entry, a total of 40 patients who presented with aphthous ulcers were included. Patients were received Amlexanox or Adcortyl four times daily for 7 days. Patients were evaluated for pain, lesion size, and tingling at one day, three days, five days and seven days follow-ups. The treatment effects were then evaluated using the Wilcoxon-Mann-Whitney (WMW) test. Values ofp<0.05 were considered significant.
  
  
  RESULTS
  No significant differences in pain score, tingling and lesion size were observed on similar days between Amlexanox and Adcortyl groups. In both groups, reduction in the assessed variables was significant between days 1-3, 3-5, and 5-7 (p< 0.001).
  
  
  CONCLUSIONS
  This study indicated that Amlexanox as well as Adcortyl was effective in relieving pain and reducing the lesion size during the treatment of aphthous ulcers.Key words:Recurrent aphthous stomatitis, Amlexanox, Adcortyl, pain relief.
authors.affiliation: Associate Professor. Department of Oral Medicine, School of Dentistry, Shahed University of Medical Sciences, Tehran, Iran.
authors.forename: Farid
authors.initials: F
authors.lastname: Abbasi
authors.affiliation: Assistant Professor. Laboratory of Molecular Neuroscience, Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Raoof
authors.affiliation: Postgraduate Student of Oral Medicine. School of Dentistry, Shahed University, Tehran, Iran.
authors.forename: Roya
authors.initials: R
authors.lastname: Khatami
authors.affiliation: Assistant Professor. Department of Operative Dentistry, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Niloofar
authors.initials: N
authors.lastname: Shadman
authors.affiliation: Department of Oral Medicine, School of Dentistry, Shahed University, Tehran, Iran.
authors.forename: Farnaz
authors.initials: F
authors.lastname: Borjian-Boroojeni
authors.affiliation: Postgraduate Student of Endodontics. School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Farahnaz
authors.initials: F
authors.lastname: Nazari