title: Polymorphic Variants rs13155212 (T/C) and rs7704267 (G/C) in the AGGF1 Gene and Risk of Varicose Veins of the Lower Extremities in the Population of Ethnic Russians.
abstract: We analyzed associations between single nucleotide polymorphisms (SNP) rs13155212 and rs7704267 in the AGGF1 gene (angiogenic factor with G patch and FHA domains 1) and the risk of risk of varicose veins of the legs in ethnic Russians. Frequencies of alleles, genotypes, and haplotypes were estimated in the sample of patients with this disease (474 patients) and in the control group of participants (478 volunteers) without a history of chronic venous disease. None of the studied polymorphisms was associated with the risk of this pathology. The whole AGGF1 gene sequence lies in a single block of high linkage disequilibrium, and both studied polymorphic variants are representative of all other SNP within this region. From these results, a conclusion was made that AGGF1 gene polymorphism does not affect the risk of varicose veins of the legs in ethnic Russians, or its contribution is low and can be revealed only after analysis of larger cohorts.
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. weiner.alexserg@gmail.com.|Novosibirsk National Research State University, Novosibirsk, Russia. weiner.alexserg@gmail.com.
authors.forename: A S
authors.initials: AS
authors.lastname: Shadrina
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Smetanina
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: K S
authors.initials: KS
authors.lastname: Sevost'ianova
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.|Novosibirsk National Research State University, Novosibirsk, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Sokolova
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Shevela
authors.affiliation: N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: E I
authors.initials: EI
authors.lastname: Selivestrov
authors.affiliation: Clinic Medalp, St. Petersburg, Russia.
authors.forename: M Yu
authors.initials: MY
authors.lastname: Demekhova
authors.affiliation: Clinic Medalp, St. Petersburg, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Shonov
authors.affiliation: Clinic Medalp, St. Petersburg, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Ilyukhin
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.|Novosibirsk National Research State University, Novosibirsk, Russia.
authors.forename: E N
authors.initials: EN
authors.lastname: Voronina
authors.affiliation: N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: I A
authors.initials: IA
authors.lastname: Zolotukhin
authors.affiliation: N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Kirienko
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.|Novosibirsk National Research State University, Novosibirsk, Russia.
authors.forename: M L
authors.initials: ML
authors.lastname: Filipenko
mesh_terms: D000328:Adult; D017668:Age of Onset; D042501:Angiogenic Proteins / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D007866:Leg / Q000098:blood supply*; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D012426:Russia; D014648:Varicose Veins / Q000235:genetics*
chemical_list: C482200:AGGF1 protein, human; D042501:Angiogenic Proteins
keywords: AGGF1; SNP; rs13155212; rs7704267; varicose veins