title: Ginger extract protects rat's kidneys against oxidative damage after chronic ethanol administration.
abstract: Chronic alcohol ingestion is associated with pronounced detrimental effects on the renal system. In the current study, the protective effect of ginger extract on ethanol-induced damage was evaluated through determining 8-OHdG, cystatin C, glomerular filtration rate, and pathological changes such as cell proliferation and fibrosis in rats' kidneys. Male wistar rats were randomly divided into three groups and were treated as follows: (1) control, (2) ethanol and (3) ginger extract treated ethanolic (GETE) groups. After a six weeks period of treatment, the results revealed proliferation of glomerular and tubular cells, fibrosis in glomerular and peritubular and a significant rise in the level of 8-OHdG, cystatin C, plasma urea and creatinine. Moreover, compared to the control group, the ethanol group showed a significant decrease in the urine creatinine and creatinine clearance. In addition, significant amelioration of changes in the structure of kidneys, along with restoration of the biochemical alterations were found in the ginger extract treated ethanolic group, compared to the ethanol group. These findings indicate that ethanol induces kidneys abnormality by oxidative DNA damage and oxidative stress, and that these effects can be alleviated using ginger as an antioxidant and anti-inflammatory agent.
authors.affiliation: Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran; Nephrology and kidney Transplant Research Center, Urmia University of Medical Sciences, Urmia, Iran. Electronic address: ashirpoor@yahoo.com.
authors.forename: Aireza
authors.initials: A
authors.lastname: Shirpoor
authors.affiliation: Nephrology and kidney Transplant Research Center, Urmia University of Medical Sciences, Urmia, Iran.
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Rezaei
authors.affiliation: Nephrology and kidney Transplant Research Center, Urmia University of Medical Sciences, Urmia, Iran.
authors.forename: Amin Abdollahzade
authors.initials: AA
authors.lastname: Fard
authors.affiliation: Nephrology and kidney Transplant Research Center, Urmia University of Medical Sciences, Urmia, Iran.
authors.forename: Ali Taghizadeh
authors.initials: AT
authors.lastname: Afshari
authors.affiliation: Nephrology and kidney Transplant Research Center, Urmia University of Medical Sciences, Urmia, Iran.
authors.forename: Farzaneh Hosseini
authors.initials: FH
authors.lastname: Gharalari
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran; Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran.
authors.forename: Yousef
authors.initials: Y
authors.lastname: Rasmi
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D000431:Ethanol / Q000008:administration & dosage / Q000633:toxicity*; D020939:Zingiber officinale; D007674:Kidney Diseases / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D020011:Protective Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D020011:Protective Agents; D000431:Ethanol
keywords: DNA damage; Ethanol; Ginger; Kidney; Rat