title: p62 in Liver Disease: Good Guy or Bad Guy?
abstract: The multidomain adaptor protein p62 has been suggested to exert pro-oncogenic functions in hepatocytes and other epithelial cells. In this issue of Cancer Cell, Duran et al. show that p62 acts as a non-cell-autonomous tumor suppressor in liver cancer by counteracting the activation of hepatic stellate cells.
authors.affiliation: Department of Internal Medicine VIII, University Hospital Tübingen, 72076 Tübingen, Germany; Department of Physiology I, Institute of Physiology, Eberhard Karls University Tübingen, Otfried-Müller-Str. 14, 72076 Tübingen, Germany.
authors.forename: Zexi
authors.initials: Z
authors.lastname: Hu
authors.affiliation: Department of Internal Medicine VIII, University Hospital Tübingen, 72076 Tübingen, Germany; Department of Physiology I, Institute of Physiology, Eberhard Karls University Tübingen, Otfried-Müller-Str. 14, 72076 Tübingen, Germany; Translational Gastrointestinal Oncology Group within the German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg 69120, Germany. Electronic address: lars.zender@med.uni-tuebingen.de.
authors.forename: Lars
authors.initials: L
authors.lastname: Zender
mesh_terms: D004847:Epithelial Cells; D016147:Genes, Tumor Suppressor; D022781:Hepatocytes; D006801:Humans; D008113:Liver Neoplasms