title: A severe case of systemic lupus erythematosus with increased pressure communicating hydrocephalus.
abstract: Normal/increased pressure hydrocephaly is an unusual manifestation of systemic lupus erythematosus (SLE), and the pathogenesis is still unclear. We report the case of an 18-year-old white female with severe refractory renal and pulmonary involvement who developed stupor during intensive immunosuppressive treatment. Enlarged ventricles on imaging and increased intracranial pressure with the exclusion of infectious and hemorrhagic/thrombotic processes suggested increased pressure communicating hydrocephalus associated with SLE. Few case reports are reviewed, and potential pathophysiologic mechanisms are discussed.
authors.affiliation: Department of Rheumatology, Marmara University, Faculty of Medicine, Istanbul, Turkey.
authors.forename: Gülşen
authors.initials: G
authors.lastname: Özen
authors.affiliation: Department of Rheumatology, Marmara University, Faculty of Medicine, Istanbul, Turkey.
authors.forename: Sibel
authors.initials: S
authors.lastname: Yılmaz-Öner
authors.affiliation: Department of Neurology, Marmara University, Faculty of Medicine, Istanbul, Turkey.
authors.forename: Neşe
authors.initials: N
authors.lastname: Tuncer
authors.affiliation: Department of Internal Medicine and Critical Care Unit, Marmara University, Faculty of Medicine, Istanbul, Turkey.
authors.forename: Türkay
authors.initials: T
authors.lastname: Akbaş
authors.affiliation: Department of Nephrology, Marmara University, Faculty of Medicine, Istanbul, Turkey.
authors.forename: Serhan
authors.initials: S
authors.lastname: Tuğlular
authors.affiliation: Department of Rheumatology, Marmara University, Faculty of Medicine, Istanbul, Turkey.
authors.forename: Haner
authors.initials: H
authors.lastname: Direskeneli
keywords: Hydrocephalus; increased pressure communicating; systemic lupus erythematosus