title: Prophylactic clipping and post-polypectomy bleeding: a meta-analysis and systematic review.
abstract: BACKGROUND
  Bleeding after polypectomy is a common issue associated with colonoscopy. To help prevent post-polypectomy bleeding, many endoscopists place clips at the site. However, this practice remains controversial. Therefore, we performed a meta-analysis of the efficacy of clip placement in the prevention of post-polypectomy bleeding.
  
  
  METHODS
  Multiple databases, including Embase, Scopus, MEDLINE/PubMed, CINAHL, Cochrane databases, and recent abstracts from major American meetings were searched in April 2016. Using the DerSimonian and Laird (random effects) model with odds ratio (OR), a meta-analysis was performed of post-polypectomy bleeding with prophylactic clip versus no prophylactic clip.
  
  
  RESULTS
  Five hundred and thirty potential articles and abstracts were discovered. Thirty-five articles were reviewed, with 12 studies satisfying the inclusion criteria. No statistically significant difference in prophylactic clipping versus no prophylactic clipping for post-polypectomy bleeding in all polyps was found when all studies (OR 1.49; 95% CI: 0.56-4.00; P=0.42), only peer-reviewed studies where abstracts were excluded (OR 0.84; 95% CI: 0.42-1.69; P=0.63), and only randomized controlled trials (OR 1.24; 95% CI: 0.69-2.24; P=0.47) were analyzed.
  
  
  CONCLUSIONS
  The use of prophylactic clipping for all polypectomies does not seem to prevent post-polypectomy bleeding and should not be a routine practice. However, for large polyps (>2 cm), prophylactic clipping may or may not be beneficial in preventing post-polypectomy bleeding. Further studies are required to fully evaluate this subgroup.
authors.affiliation: Department of Medicine, University of Missouri, Columbia (Christine Boumitri, Fazia A. Mir, Imran Ashraf, Michelle L. Matteson-Kome, Matthew L. Bechtold), USA.
authors.forename: Christine
authors.initials: C
authors.lastname: Boumitri
authors.affiliation: Department of Medicine, University of Missouri, Columbia (Christine Boumitri, Fazia A. Mir, Imran Ashraf, Michelle L. Matteson-Kome, Matthew L. Bechtold), USA.
authors.forename: Fazia A
authors.initials: FA
authors.lastname: Mir
authors.affiliation: Department of Medicine, University of Missouri, Columbia (Christine Boumitri, Fazia A. Mir, Imran Ashraf, Michelle L. Matteson-Kome, Matthew L. Bechtold), USA.
authors.forename: Imran
authors.initials: I
authors.lastname: Ashraf
authors.affiliation: Department of Medicine, University of Missouri, Columbia (Christine Boumitri, Fazia A. Mir, Imran Ashraf, Michelle L. Matteson-Kome, Matthew L. Bechtold), USA.
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Matteson-Kome
authors.affiliation: Department of Medicine, University of California, Irvine (Douglas L. Nguyen), USA.
authors.forename: Douglas L
authors.initials: DL
authors.lastname: Nguyen
authors.affiliation: Department of Medicine, University of Illinois, Peoria (Srinivas R. Puli), USA, USA.
authors.forename: Srinivas R
authors.initials: SR
authors.lastname: Puli
authors.affiliation: Department of Medicine, University of Missouri, Columbia (Christine Boumitri, Fazia A. Mir, Imran Ashraf, Michelle L. Matteson-Kome, Matthew L. Bechtold), USA.
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Bechtold
keywords: Prophylactic; bleeding; clip; polypectomy