title: 25 hydroxy vitamin D is higher when a renal multivitamin is given with cholecalciferol at hemodialysis.
abstract: OBJECTIVE
  Seventy six hemodialysis (HD) patients were used in a prospective randomized and clinical trial to determine if a multivitamin with vitamin D (cholecalciferol 12,000 IU/week) given during dialysis would improve the vitamin D status of hemodialysis subjects.
  
  
  METHODS
  Subjects were randomly assigned to two groups: 37 subjects were in the renal multivitamin without vitamin D (MV) group and 39 subjects were in a multivitamin route with vitamin D (MVD) group (12,000 IU of cholecalciferol per week). All subjects were given 2 multivitamin tablets at their 3 HD sessions each week for 20 weeks. Serum 25(OH)D, calcium (Ca), and phosphorus (P) levels were evaluated.
  
  
  RESULTS
  At baseline, mean serum 25(OH)D were below adequate (<30 ng/mL) in the MV group (23.5±12.2 ng/mL) and in the MVD group (20.8±10.3 ng/mL). A significant increase was seen in serum 25(OH)D levels (37.7±11.4 ng/mL; p<0.001) in the MVD group after vitamin D supplementation with no rise in the MV group value (21.7±11.4 ng/mL; p=0.06). Prior to supplementation, 17.9% of patients in the MVD group had adequate serum 25(OH)D level and post supplementation 76.9% in the MVD group had adequate serum 25(OH)D. In the MV group, 18.9% subjects had adequate serum 25(OH)D levels at baseline with 18.9% having 25(OH)D >30 ng/mL at the end of the study. There were no significant differences in group values for serum Ca and P.
  
  
  CONCLUSIONS
  The majority of HD subjects given a multivitamin with cholecalciferol at dialysis had improvement in their vitamin D status.
authors.affiliation: Department of Nutritional Sciences, Texas Tech University, Lubbock, Texas, USA.|Department of Nutrition and Food Technology, Faculty of Agriculture, Jordan University of Science and Technology, Irbid, Jordan. Email: hssubih@just.edu.jo.
authors.forename: Hadil S
authors.initials: HS
authors.lastname: Subih
authors.affiliation: Dietetics, Covenant Med. Ctr., Lubbock, Texas, USA.
authors.forename: Janaye
authors.initials: J
authors.lastname: Behrens
authors.affiliation: Department of Nutritional Sciences, Texas Tech University, Lubbock, Texas, USA.
authors.forename: Brooke
authors.initials: B
authors.lastname: Burt
authors.affiliation: South Plains Kidney Disease Ctr., Lubbock, Texas, USA.
authors.forename: Louise
authors.initials: L
authors.lastname: Clement
authors.affiliation: Redbud Dialysis Ctr., Lubbock, Texas, USA.
authors.forename: Rita
authors.initials: R
authors.lastname: Pannell
authors.affiliation: Redbud Dialysis Ctr., Lubbock, Texas, USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Macha
authors.affiliation: Department of Nutritional Sciences, Texas Tech University, Lubbock, Texas, USA.
authors.forename: Julian
authors.initials: J
authors.lastname: Spallholz
authors.affiliation: Department of Nutritional Sciences, Texas Tech University, Lubbock, Texas, USA.
authors.forename: Mallory
authors.initials: M
authors.lastname: Boylan
mesh_terms: D000368:Aged; D002762:Cholecalciferol / Q000008:administration & dosage*; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D006435:Renal Dialysis; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000517:prevention & control; D014815:Vitamins / Q000008:administration & dosage*
chemical_list: D014815:Vitamins; D014807:Vitamin D; D002762:Cholecalciferol; C104450:25-hydroxyvitamin D