title: Epigenetics in Multiple Myeloma.
abstract: Multiple myeloma is characterized by clonal proliferation of plasma cells within the bone marrow resulting in anemia, lytic bone lesions, hypercalcemia, and renal impairment. Despite advanced in our understanding of this complex disease in recent years, it is still considered an incurable malignancy. This is, in part, due to the highly heterogenous genomic and phenotypic nature of the disease, which is to date incompletely understood. It is clear that a deeper level of knowledge of the biological events underlying the development of these diseases is needed to identify new targets and generate effective novel therapies. MicroRNAs (miRNAs), which are single strand, 20-nucleotide, noncoding RNA's, are key regulators of gene expression and have been reported to exert transcriptional control in multiple myeloma. miRNAs are now recognized to play a role in many key areas such as cellular proliferation, differentiation, apoptosis and stress response. Substantial advances have been made in recent years in terms of our understanding of the biological role of miRNAs in a diverse range of hematological and solid malignancues, In multiple myeloma these advances have yielded new information of prognostic and diagnostic relevance which have helped to shed light on epigenetic regulation in this disease.
authors.affiliation: Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: Siobhan V
authors.initials: SV
authors.lastname: Glavey
authors.affiliation: Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: Salomon
authors.initials: S
authors.lastname: Manier
authors.affiliation: Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: Antonio
authors.initials: A
authors.lastname: Sacco
authors.affiliation: Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: Karma
authors.initials: K
authors.lastname: Salem
authors.affiliation: Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: Yawara
authors.initials: Y
authors.lastname: Kawano
authors.affiliation: Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: Juliette
authors.initials: J
authors.lastname: Bouyssou
authors.affiliation: Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: Irene M
authors.initials: IM
authors.lastname: Ghobrial
authors.affiliation: Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA, USA. aldomaria.roccaro@asst-spedalicivili.it.|Department of Hematology, CREA Laboratory, ASST-Spedali Civili di Brescia, Brescia, BS, Italy. aldomaria.roccaro@asst-spedalicivili.it.
authors.forename: Aldo M
authors.initials: AM
authors.lastname: Roccaro
mesh_terms: D044127:Epigenesis, Genetic; D006801:Humans; D009101:Multiple Myeloma / Q000235:genetics*
keywords: DNA acetylation; Epigenetics; Methylation; miRNA