title: MicroRNA variants and colorectal cancer risk: a meta-analysis.
abstract: Colorectal cancer (CRC) is a multi-factorial disease, and genetic background may contribute to its etiology. Single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) may be used as specific markers of predisposition for CRC diagnosis and prevention. In this review, we summarize and discuss recent publications evaluating the roles of miRNA SNPs in CRC. A meta-analysis was also carried out to assess the association between the five most frequently studied miRNA SNPs and CRC risk. No relationship was established between this disease and the three SNPs rs11614913, rs2910164, and rs3746444 in miR-196a-2, miR-146a, and miR-499, respectively. However, polymorphisms of miR-149 (rs2292832; CT vs TT: odds ratio [OR] = 0.816, 95% confidence interval [CI] = 0.691-0.963; CC+CT vs TT: OR = 0.834, 95%CI = 0.715-0.972) and pre-miR-27a (rs895819; GG vs AA: OR = 1.534, 95%CI = 1.148-2.049; GG+AG vs AA: OR = 1.324, 95%CI = 1.066-1.645) were found to be associated with CRC in our analysis. In conclusion, the SNPs rs2292832 in miR-149 and rs895819 in pre-miR-27a were associated with CRC susceptibility, whereas rs11614913, rs2910164, and rs3746444 in miR-196a-2, miR-146a, and miR-499, respectively, were not. Further studies should be carried out to validate these findings.
authors.affiliation: Department of Forensic Pathology, Henan University of Science and Technology, Luoyang, Henan, China.
authors.forename: X M
authors.initials: XM
authors.lastname: Pan
authors.affiliation: Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: X
authors.initials: X
authors.lastname: Xiao
authors.affiliation: Department of Forensic Pathology, Henan University of Science and Technology, Luoyang, Henan, China.
authors.forename: H J
authors.initials: HJ
authors.lastname: Qin
authors.affiliation: Department of Forensic Pathology, Henan University of Science and Technology, Luoyang, Henan, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Secondary Department of General Surgery, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan, China.
authors.forename: Z H
authors.initials: ZH
authors.lastname: Li
authors.affiliation: Laboratory of Molecular and Translational Medicine, West China Institute of Women and Children's Health, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: L B
authors.initials: LB
authors.lastname: Gao
authors.affiliation: Center for Molecular Medicine, Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang, China ann_nance@sina.com.cn.
authors.forename: J
authors.initials: J
authors.lastname: Jia
mesh_terms: D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C551557:MIRN149 microRNA, human; C531388:MIRN27 microRNA, human; D035683:MicroRNAs