title: Outpatient Antibiotic Prescribing Practices for Uncomplicated Urinary Tract Infection in Women in the United States, 2002-2011.
abstract: Background.Urinary tract infection (UTI) is one of the most common diagnoses leading to an antibiotic prescription for women seeking ambulatory care. Understanding current national outpatient antibiotic prescribing practices will help ongoing stewardship efforts to optimize antibiotic use; however, information on recent national outpatient antibiotic prescribing trends for UTI is limited.Methods.We analyzed the National Ambulatory Medical Care and National Hospital Ambulatory Medical Care Survey datasets from 2002 to 2011. Outpatient visits of women aged ≥18 years with a diagnosis of uncomplicated UTI were included for analysis. We conducted weighted descriptive analyses, examined time trends in antibiotic prescribing, and used multivariable logistic regression to identify patient and provider factors associated with fluoroquinolone prescribing.Results.A total of 7111 visits were identified. Eighty percent of visits resulted in an antibiotic prescription; fluoroquinolones were the most frequently prescribed antibiotics throughout the study period (49% overall). Older patients (adjusted odds ratio [AOR] for adults aged ≥70 years = 2.5; 95% confidence interval [CI], 1.6-3.8) and patients treated by internists (AOR = 2.0; 95% CI, 1.1-3.3) were more likely than younger patients and those treated by family practitioners to receive fluoroquinolones. Outpatient visits in the West US Census region were less likely to be associated with fluoroquinolone prescribing (AOR = 0.6; 95% CI, .4-1.0) compared with visits in the Northeast.Conclusions.Fluoroquinolones were the most frequently selected antibiotic treatment for uncomplicated UTI in women during the study period. Outpatient antibiotic stewardship initiatives should include efforts to reduce overuse of fluoroquinolones for uncomplicated UTI.
authors.affiliation: National Center for Immunization and Respiratory Diseases, Division of Bacterial Diseases; Epidemic Intelligence Service.
authors.forename: Miwako
authors.initials: M
authors.lastname: Kobayashi
authors.affiliation: School of Medicine , University of California , San Francisco.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Shapiro
authors.affiliation: Department of Pediatrics, Division of Pediatric Infectious Diseases , University of Utah , Salt Lake City.
authors.forename: Adam L
authors.initials: AL
authors.lastname: Hersh
authors.affiliation: National Center for Emerging and Zoonotic Infectious Diseases, Division of Healthcare Quality Promotion , Centers for Disease Control and Prevention , Atlanta, Georgia.
authors.forename: Guillermo V
authors.initials: GV
authors.lastname: Sanchez
authors.affiliation: National Center for Emerging and Zoonotic Infectious Diseases, Division of Healthcare Quality Promotion , Centers for Disease Control and Prevention , Atlanta, Georgia.
authors.forename: Lauri A
authors.initials: LA
authors.lastname: Hicks
keywords: adverse drug event; fluoroquinolone; outpatient antibiotic stewardship; uncomplicated urinary tract infection