title: BDNF Responses in Healthy Older Persons to 35 Minutes of Physical Exercise, Cognitive Training, and Mindfulness: Associations with Working Memory Function.
abstract: Brain-derived neurotrophic factor (BDNF) has a central role in brain plasticity by mediating changes in cortical thickness and synaptic density in response to physical activity and environmental enrichment. Previous studies suggest that physical exercise can augment BDNF levels, both in serum and the brain, but no other study has examined how different types of activities compare with physical exercise in their ability to affect BDNF levels. By using a balanced cross over experimental design, we exposed nineteen healthy older adults to 35-minute sessions of physical exercise, cognitive training, and mindfulness practice, and compared the resulting changes in mature BDNF levels between the three activities. We show that a single bout of physical exercise has significantly larger impact on serum BDNF levels than either cognitive training or mindfulness practice in the same persons. This is the first study on immediate BDNF effects of physical activity in older healthy humans and also the first study to demonstrate an association between serum BDNF responsivity to acute physical exercise and working memory function. We conclude that the BDNF increase we found after physical exercise more probably has a peripheral than a central origin, but that the association between post-intervention BDNF levels and cognitive function could have implications for BDNF responsivity in serum as a potential marker of cognitive health.
authors.affiliation: Department of Psychology, Linnaeus University, Växjö, Sweden.|Center for Alzheimer Research, Division of Neurogeriatrics, Department of NVS, Karolinska Institutet, Stockholm, Sweden.|Aging Research Center (ARC), Department of NVS, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
authors.forename: Krister
authors.initials: K
authors.lastname: Håkansson
authors.affiliation: Department of Neurosciences and the Center on Aging, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Ledreux
authors.affiliation: Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Kirk
authors.initials: K
authors.lastname: Daffner
authors.affiliation: Department of Psychology, Linnaeus University, Växjö, Sweden.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Terjestam
authors.affiliation: Department of Sport Science, Linnaeus University, Växjö, Sweden.
authors.forename: Patrick
authors.initials: P
authors.lastname: Bergman
authors.affiliation: Department of Psychology, Linnaeus University, Växjö, Sweden.
authors.forename: Roger
authors.initials: R
authors.lastname: Carlsson
authors.affiliation: Center for Alzheimer Research, Division of Neurogeriatrics, Department of NVS, Karolinska Institutet, Stockholm, Sweden.|Aging Research Center (ARC), Department of NVS, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
authors.forename: Miia
authors.initials: M
authors.lastname: Kivipelto
authors.affiliation: Center for Alzheimer Research, Division of Neurogeriatrics, Department of NVS, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Bengt
authors.initials: B
authors.lastname: Winblad
authors.affiliation: Department of Neurosciences and the Center on Aging, Medical University of South Carolina, Charleston, SC, USA.|The Knoebel Institute for Healthy Aging, University of Denver, Denver, CO, USA.
authors.forename: Ann-Charlotte
authors.initials: AC
authors.lastname: Granholm
authors.affiliation: Department of Psychology, Linnaeus University, Växjö, Sweden.|Center for Alzheimer Research, Division of Neurogeriatrics, Department of NVS, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Abdul Kadir H
authors.initials: AK
authors.lastname: Mohammed
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001921:Brain / Q000378:metabolism*; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D003071:Cognition; D018592:Cross-Over Studies; D015444:Exercise / Q000502:physiology*; D005260:Female; D000073656:Healthy Aging / Q000502:physiology*; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D064866:Mindfulness / Q000379:methods*; D013663:Teaching
chemical_list: D019208:Brain-Derived Neurotrophic Factor
keywords: Aging; brain-derived neurotrophic factor; cognitive function; cognitive training; crossover design; exercise; geriatrics; intervention study; mindfulness; neuroplasticity