title: Cytochalasin P1, a new cytochalasin from the marine-derived fungus Xylaria sp. SOF11.
abstract: A new cytochalasin, named cytochalasin P1 (1), together with four known analogs (2-5) was isolated from marine-derived fungus Xylaria sp. SOF11 from the South China Sea. The structure of the new compound was elucidated on the basis of MS and NMR (1H, 13C, HSQC, HMBC, and NOESY) data analyses. Compounds 1-5 were tested for their cytotoxicities against four tumor cell lines (SF-268, MCF-7, NCI-H460, and HepG-2). Compounds 1-5 showed significant cytotoxicity against two tumor cell lines MCF-7 and SF-268, with the IC50 values varying between 0.33 and 4.17 μM.
authors.affiliation: School of Chemistry and Chemical Engineering, Lingnan Normal University, 29# Cunjin Road, Zhanjiang 524048, China, Tel./Fax: +86-075-9318-3245.
authors.forename: Ziming
authors.initials: Z
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Applied Microbiology Southern China, Guangdong Institute of Microbiology, 100 Central Xianlie Road, Guangzhou 510070, China.
authors.forename: Yuchan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, 164 West Xingang Road, Guangzhou 510301, China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Huang
authors.affiliation: School of Chemistry and Chemical Engineering, Lingnan Normal University, Zhanjiang 524048, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Applied Microbiology Southern China, Guangdong Institute of Microbiology, 100 Central Xianlie Road, Guangzhou 510070, China.
authors.forename: Weimin
authors.initials: W
authors.lastname: Zhang
authors.affiliation: School of Life Science and Technology, Lingnan Normal University, Zhanjiang 524048, China.
authors.forename: Yulin
authors.initials: Y
authors.lastname: Sun
authors.affiliation: School of Life Science and Technology, Lingnan Normal University, Zhanjiang 524048, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wen
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D059001:Aquatic Organisms; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003572:Cytochalasins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009928:Organ Specificity; D013098:Xylariales / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D003572:Cytochalasins; C000620611:cytochalasin P1