title: Crystal engineering of a zwitterionic drug to neutral cocrystals: a general solution for floxacins.
abstract: The transformation of zwitterionic Sparfloxacin (SPX) to the neutral form is achieved by cocrystallization. Neutral forms of drugs are important for higher membrane permeability, while zwitterions are more soluble in water. The twin advantages of higher solubility/dissolution rate and good stability of neutral SPX are achieved in a molecular cocrystal compared to its zwitterionic SPX hydrate. The amine-phenol supramolecular synthon drives cocrystal formation, with the paraben ester acting as a "proton migrator" for the ionic to neutral transformation.
authors.affiliation: School of Chemistry, University of Hyderabad, Prof. C. R. Rao Road, Gachibowli Central University P.O., Hyderabad 500046, India. ashwini.nangia@gmail.com.
authors.forename: Anilkumar
authors.initials: A
authors.lastname: Gunnam
authors.affiliation: School of Chemistry, University of Hyderabad, Prof. C. R. Rao Road, Gachibowli Central University P.O., Hyderabad 500046, India. ashwini.nangia@gmail.com.
authors.forename: Kuthuru
authors.initials: K
authors.lastname: Suresh
authors.affiliation: Solid State and Structural Chemistry Unit, Indian Institute of Science, Bengaluru 560012, India.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Ganduri
authors.affiliation: School of Chemistry, University of Hyderabad, Prof. C. R. Rao Road, Gachibowli Central University P.O., Hyderabad 500046, India. ashwini.nangia@gmail.com and CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India. ak.nangia@ncl.res.in.
authors.forename: Ashwini
authors.initials: A
authors.lastname: Nangia