title: Clinical Relevance and Molecular Phenotypes in Gastric Cancer, of TP53 Mutations and Gene Expressions, in Combination With Other Gene Mutations.
abstract: While altered TP53 is the most frequent mutation in gastric cancer (GC), its association with molecular or clinical phenotypes (e.g., overall survival, disease-free survival) remains little known. To that end, we can use genome-wide approaches to identify altered genes significantly related to mutated TP53. Here, we identified significant differences in clinical outcomes, as well as in molecular phenotypes, across specific GC tumor subpopulations, when combining TP53 with other signaling networks, including WNT and its related genes NRXN1, CTNNB1, SLITRK5, NCOR2, RYR1, GPR112, MLL3, MTUS2, and MYH6. Moreover, specific GC subpopulations indicated by dual mutation of NRXN1 and TP53 suggest different drug responses, according to the Connectivity Map, a pharmacological drug-gene association tool. Overall, TP53 mutation status in GC is significantly relevant to clinical or molecular categories. Thus, our approach can potentially provide a patient stratification strategy by dissecting previously unknown multiple TP53-mutated patient groups.
authors.affiliation: New Experimental Therapeutics Branch, National Cancer Center, Goyang-si Gyeonggi-do, 10408, Korea.|Department of Biomedical Engineering, Inje University, Gimhae, Gyeongnam, 50834, Korea.|Department of Life Sciences, College of BioNano Technology, Gachon University, Seongnam-si, Gyeonggi-do, 13120, Korea.|College of Medicine, Gachon University, Incheon, 21936, Korea.
authors.forename: Sungjin
authors.initials: S
authors.lastname: Park
authors.affiliation: Korean Bioinformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, Korea.|Department of Nanobiotechnology and Bioinformatics, University of Science and Technology, Daejeon, 34113, Korea.
authors.forename: Jinhyuk
authors.initials: J
authors.lastname: Lee
authors.affiliation: New Experimental Therapeutics Branch, National Cancer Center, Goyang-si Gyeonggi-do, 10408, Korea.|CrystalGenomics, Inc., Seongnam-si, Gyeonggi-do, 13488, Korea.
authors.forename: Yon Hui
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Digital Information Computing Center, Inje University, Gimhae, Gyeongnam, 50834, Korea.
authors.forename: Jaheun
authors.initials: J
authors.lastname: Park
authors.affiliation: Department of Biomedical Engineering, Inje University, Gimhae, Gyeongnam, 50834, Korea.
authors.forename: Jung-Woog
authors.initials: JW
authors.lastname: Shin
authors.affiliation: New Experimental Therapeutics Branch, National Cancer Center, Goyang-si Gyeonggi-do, 10408, Korea.|Department of Life Sciences, College of BioNano Technology, Gachon University, Seongnam-si, Gyeonggi-do, 13120, Korea.|College of Medicine, Gachon University, Incheon, 21936, Korea.
authors.forename: Seungyoon
authors.initials: S
authors.lastname: Nam
mesh_terms: D002135:Calcium-Binding Proteins; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics; D045744:Cell Line, Tumor; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics; D019006:Neural Cell Adhesion Molecules; D010641:Phenotype; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000401:mortality; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism; D051176:beta Catenin / Q000235:genetics
chemical_list: C495270:CTNNB1 protein, human; D002135:Calcium-Binding Proteins; D015816:Cell Adhesion Molecules, Neuronal; C539628:NRXN1 protein, human; D009419:Nerve Tissue Proteins; D019006:Neural Cell Adhesion Molecules; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D051176:beta Catenin