title: Association of NT-proANP Level in Plasma and Humor Aqueous with Primary Open-Angle Glaucoma.
abstract: The aim of this study is to determine differences in the levels of NT-proANP in the plasma and aqueous humor of glaucoma and cataract patients and to evaluate whether any relationships are present.
  
  
  
  The study group consisted of 58 patients with primary-open glaucoma (POAG) undergoing trabeculectomy surgery. The control group was comprised of 32 age-matched cataract patients. The concentration of the N-terminal fragment of the proatrial natriuretic peptide (NT-proANP, 1-98) in the aqueous humor and blood plasma samples was measured using an immunochemical method (ELISA).
  
  
  
  The plasma NT-proANP concentration was significantly increased in patients with POAG compared to that in the control group (7.00 vs. 4.65 nmol/L, P = 0.0054). Similarly, the NT-proANP concentration in the aqueous humor was significantly higher in the POAG patients (0.47 vs. 0.09 nmol/L, P = 0.0112). However, there was no correlation between the NT-proANP values in the aqueous humor and the plasma of the POAG patients, as well as between the NT-proANP values in the aqueous humor and the intraocular pressure.
  
  
  
  We identified an association between the levels of NT-proANP in the plasma and the aqueous humor with POAG. Our data support the idea of the involvement of NP system in the development of POAG and highlight ANP as a possible biomarker of glaucoma.
authors.affiliation: a Department of Ophthalmology , Riga Stradiņš University , Riga , Latvia.|b Department of Ophthalmology , Pauls Stradins Clinical University Hospital , Riga , Latvia.
authors.forename: Kristine
authors.initials: K
authors.lastname: Baumane
authors.affiliation: a Department of Ophthalmology , Riga Stradiņš University , Riga , Latvia.|c Latvian Biomedical Research and Study Centre , Riga , Latvia.
authors.forename: Renate
authors.initials: R
authors.lastname: Ranka
authors.affiliation: a Department of Ophthalmology , Riga Stradiņš University , Riga , Latvia.|b Department of Ophthalmology , Pauls Stradins Clinical University Hospital , Riga , Latvia.
authors.forename: Guna
authors.initials: G
authors.lastname: Laganovska
mesh_terms: D000368:Aged; D001082:Aqueous Humor / Q000378:metabolism*; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D002386:Cataract / Q000378:metabolism; D002387:Cataract Extraction; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005902:Glaucoma, Open-Angle / Q000378:metabolism* / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D014130:Trabeculectomy
chemical_list: D015415:Biomarkers; D009320:Atrial Natriuretic Factor
keywords: Atrial natriuretic peptide; aqueous humor; glaucoma; surgery; vascular factor