title: Selective Functionalization of Pyridines via Heterocyclic Phosphonium Salts.
abstract: Methods that directly functionalize pyridines are in high demand due to their presence in pharmaceuticals, agrochemicals, and materials. A reaction that selectively transforms the 4-position C-H bonds in pyridines into C-PPh3+groups that are subsequently converted into heteroaryl ethers is presented. The two step sequence is effective on complex pyridines, pharmaceutical molecules, and other classes of heterocycles. Initial studies show that C-C, C-N, and C-S bond formations are also amenable.
authors.affiliation: Department of Chemistry, Colorado State University , Fort Collins, Colorado 80523, United States.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Hilton
authors.affiliation: Department of Chemistry, Colorado State University , Fort Collins, Colorado 80523, United States.
authors.forename: Ryan D
authors.initials: RD
authors.lastname: Dolewski
authors.affiliation: Department of Chemistry, Colorado State University , Fort Collins, Colorado 80523, United States.
authors.forename: Andrew
authors.initials: A
authors.lastname: McNally