title: How apomorphine should be used to treat Parkinson's disease.
abstract: The key clinical features of Parkinson's disease are tremor, rigidity and bradykinesia. Oral levodopa is the usual initial treatment but, in advanced Parkinson's disease, patients can begin to experience dyskinesias and prolonged hypomobility episodes or 'off periods'. Apomorphine is a short-acting dopamine-receptor agonist that can be used to prevent or reverse 'off period'.