title: Intelligent polymeric micelles: development and application as drug delivery for docetaxel.
abstract: Recent years, docetaxel (DTX)-loaded intelligent polymeric micelles have been regarded as a promising vehicle for DTX for the reason that compared with conventional DTX-loaded micelles, DTX-loaded intelligent micelles not only preserve the basic functions of micelles such as DTX solubilization, enhanced accumulation in tumor tissue, and improved bioavailability and biocompatibility of DTX, but also possess other new properties, for instance, tumor-specific DTX delivery and series of responses to endogenous or exogenous stimulations. In this paper, basic theories and action mechanism of intelligent polymeric micelles are discussed in detail, especially the related theories of DTX-loaded stimuli-responsive micelles. The relevant examples of stimuli-responsive DTX-loaded micelles are also provided in this paper to sufficiently illustrate the advantages of relevant technology for the clinical application of anticancer drug, especially for the medical application of DTX.
authors.affiliation: a Department of Pharmaceutics , College of Pharmacy, Shandong University , Jinan , China.
authors.forename: Yimu
authors.initials: Y
authors.lastname: Li
authors.affiliation: a Department of Pharmaceutics , College of Pharmacy, Shandong University , Jinan , China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: a Department of Pharmaceutics , College of Pharmacy, Shandong University , Jinan , China.
authors.forename: Guang-Xi
authors.initials: GX
authors.lastname: Zhai
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001682:Biological Availability; D045744:Cell Line, Tumor; D000077143:Docetaxel; D004798:Enzymes / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008027:Light; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D008823:Micelles; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D011108:Polymers / Q000737:chemistry*; D043823:Taxoids / Q000008:administration & dosage* / Q000493:pharmacokinetics; D013696:Temperature
chemical_list: D000970:Antineoplastic Agents; D004798:Enzymes; D008823:Micelles; D011108:Polymers; D043823:Taxoids; D000077143:Docetaxel
keywords: Polymeric micelles; cancer therapy; docetaxel; drug delivery; intelligent; stimuli-responsive