title: A promising new mechanism of ionizing radiation detection for positron emission tomography: modulation of optical properties.
abstract: Using conventional scintillation detection, the fundamental limit in positron emission tomography (PET) time resolution is strongly dependent on the inherent temporal variances generated during the scintillation process, yielding an intrinsic physical limit for the coincidence time resolution of around 100 ps. On the other hand, modulation mechanisms of the optical properties of a material exploited in the optical telecommunications industry can be orders of magnitude faster. In this paper we borrow from the concept of optics pump-probe measurement to for the first time study whether ionizing radiation can produce modulations of optical properties, which can be utilized as a novel method for radiation detection. We show that a refractive index modulation of approximately [Formula: see text] is induced by interactions in a cadmium telluride (CdTe) crystal from a 511 keV photon source. Furthermore, using additional radionuclide sources, we show that the amplitude of the optical modulation signal varies linearly with both the detected event rate and average photon energy of the radiation source.
authors.affiliation: Department of Electrical Engineering, Stanford University, Stanford, CA, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Tao
authors.forename: Henry M
authors.initials: HM
authors.lastname: Daghighian
authors.forename: Craig S
authors.initials: CS
authors.lastname: Levin
mesh_terms: D019187:Cadmium Compounds / Q000737:chemistry*; D009010:Monte Carlo Method; D055095:Optics and Photonics; D017785:Photons; D049268:Positron-Emission Tomography / Q000295:instrumentation* / Q000379:methods*; D011839:Radiation, Ionizing; D013691:Tellurium / Q000737:chemistry*
chemical_list: D019187:Cadmium Compounds; D013691:Tellurium; C028337:cadmium telluride