title: Contact allergens induce CD8+T cell-derived interleukin 10 that appears dispensable for regulation of contact hypersensitivity.
abstract: Interleukin 10 (IL-10) has been implied in the regulation of allergic contact dermatitis. Using transcriptional reporter mice we analyzed cellular sources of IL-10 during contact hypersensitivity (CHS) and identified IL-10 expressing CD8+T cells in the skin that are antigen-specific, display PD-1, an effector memory phenotype, and IL-10 expression comparable to that of CD4+T cells. However, in mice with a selective IL-10 deficiency in CD8+T cells CHS responses were comparable to that of controls, even in the absence of CD4+cells, suggesting that CD8+T cell-derived IL-10 does not contribute significantly to the resolution of CHS responses.
authors.affiliation: Allergy Research Group, Department of Dermatology, Medical Center-University of Freiburg, Freiburg, Germany.|Faculty of Biology, University of Freiburg, Freiburg, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Dolch
authors.affiliation: Allergy Research Group, Department of Dermatology, Medical Center-University of Freiburg, Freiburg, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Kunz
authors.affiliation: Allergy Research Group, Department of Dermatology, Medical Center-University of Freiburg, Freiburg, Germany.|Department of Dermatology and Allergology, Justus Liebig University Giessen, University Medical Center Giessen (UKGM), Giessen, Germany.
authors.forename: Britta
authors.initials: B
authors.lastname: Dorn
authors.affiliation: Institute of Immunology, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
authors.forename: Axel
authors.initials: A
authors.lastname: Roers
authors.affiliation: Allergy Research Group, Department of Dermatology, Medical Center-University of Freiburg, Freiburg, Germany.
authors.forename: Stefan F
authors.initials: SF
authors.lastname: Martin
authors.affiliation: Allergy Research Group, Department of Dermatology, Medical Center-University of Freiburg, Freiburg, Germany.|Department of Dermatology and Allergology, Justus Liebig University Giessen, University Medical Center Giessen (UKGM), Giessen, Germany.
authors.forename: Thilo
authors.initials: T
authors.lastname: Jakob
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism*; D003877:Dermatitis, Contact / Q000276:immunology*; D016753:Interleukin-10 / Q000378:metabolism*; D051379:Mice
chemical_list: C556062:IL10 protein, mouse; D016753:Interleukin-10
keywords: T cell; allergic contact dermatitis; contact hypersensitivity; immune regulation; skin