title: Cyr61 participates in the pathogenesis of acute lymphoblastic leukemia by enhancing cellular survival via the AKT/NF-κB signaling pathway.
abstract: Cyr61 (CCN1) is the product of a growth factor-inducible immediate early gene and is involved in cell adhesion, survival, proliferation, and differentiation. Cyr61 is overexpressed in human tumors and is involved in the development of tumors. However, the role that Cyr61 plays in acute lymphoblastic leukemia (ALL) cells remains undetermined. The aim of this study was to identify the role of Cyr61 in regulating ALL cell survival. Here, we found that the level of Cyr61 was increased in the plasma and bone marrow (BM) from ALL patients compared with samples from normal control patients. Furthermore, we observed that Cyr61 could effectively stimulate Jurkat (T ALL cell lines), Nalm-6 (B ALL cell lines), and primary ALL cell survival. Mechanistically, we showed that Cyr61 stimulated ALL cell survival via the AKT/NF-κB signaling pathways and the consequent up-regulation of Bcl-2. Taken together, our study is the first to reveal that Cyr61 is elevated in ALL and promotes cell survival through the AKT/NF-κB pathway by up-regulating Bcl-2. Our findings suggest that Cyr61 plays an important role in the pathogenesis of ALL.
authors.affiliation: Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou 350001, China.
authors.forename: Xianjin
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Affiliated Renmin Hospital of Fujian University of Traditional Chinese Medicine, 602 Bayiqi Road, Fuzhou 350001, China.
authors.forename: Yanfang
authors.initials: Y
authors.lastname: Song
authors.affiliation: Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou 350001, China.
authors.forename: Conglian
authors.initials: C
authors.lastname: Wu
authors.affiliation: University of Toronto, 27 King's College Circle, Toronto M5S1A1, Canada.
authors.forename: Chuxi
authors.initials: C
authors.lastname: Pan
authors.affiliation: Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou 350001, China.
authors.forename: Pingxia
authors.initials: P
authors.lastname: Lu
authors.affiliation: Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou 350001, China.
authors.forename: Meihua
authors.initials: M
authors.lastname: Wang
authors.affiliation: Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou 350001, China.
authors.forename: Peizheng
authors.initials: P
authors.lastname: Zheng
authors.affiliation: Shanghai Institute of Immunology, Institute of medical sciences, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.
authors.forename: Rongfen
authors.initials: R
authors.lastname: Huo
authors.affiliation: Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou 350001, China.
authors.forename: Chenqing
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Fujian Medical University, 88 Jiaotong Road, Fuzhou 350001, China.
authors.forename: Wanting
authors.initials: W
authors.lastname: Li
authors.affiliation: Fujian Medical University, 88 Jiaotong Road, Fuzhou 350001, China.
authors.forename: Yulin
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou 350001, China.
authors.forename: Yingping
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Shanghai Institute of Immunology, Institute of medical sciences, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.
authors.forename: Ningli
authors.initials: N
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D002470:Cell Survival / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D055515:Cysteine-Rich Protein 61 / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D019169:Jurkat Cells; D008297:Male; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
chemical_list: C000595707:BCL2 protein, human; C501848:CCN1 protein, human; D055515:Cysteine-Rich Protein 61; D016328:NF-kappa B; D019253:Proto-Oncogene Proteins c-bcl-2; D051057:Proto-Oncogene Proteins c-akt