title: The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease.
abstract: Chronic graft-versus-host disease (GVHD) is the leading cause of late, nonrelapse mortality and disability in allogeneic hematopoietic cell transplantation recipients and a major obstacle to improving outcomes. The biology of chronic GVHD remains enigmatic, but understanding the underpinnings of the immunologic mechanisms responsible for the initiation and progression of disease is fundamental to developing effective prevention and treatment strategies. The goals of this task force review are as follows: This document is intended as a review of our understanding of chronic GVHD biology and therapies resulting from preclinical studies, and as a platform for developing innovative clinical strategies to prevent and treat chronic GVHD.
authors.affiliation: Department of Oncology, Sidney Kimmel Cancer Center at Johns Hopkins Hospital, Baltimore, Maryland. Electronic address: kcooke5@jhmi.edu.
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: Cooke
authors.affiliation: Department of Oncology, Sidney Kimmel Cancer Center at Johns Hopkins Hospital, Baltimore, Maryland.
authors.forename: Leo
authors.initials: L
authors.lastname: Luznik
authors.affiliation: Division of Hematological Malignancies and Cellular Therapy, Department of Immunology and Duke Cancer Institute, Duke University, Durham, North Carolina.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Sarantopoulos
authors.affiliation: Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
authors.forename: Frances T
authors.initials: FT
authors.lastname: Hakim
authors.affiliation: Division of Hematology-Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
authors.forename: Madan
authors.initials: M
authors.lastname: Jagasia
authors.affiliation: Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Fowler
authors.affiliation: Departments of Immunology and Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: Marcel R M
authors.initials: MRM
authors.lastname: van den Brink
authors.affiliation: Division of Clinical Research, Fred Hutchinson Cancer Research Center, Department of Medicine, University of Washington, Seattle, Washington.
authors.forename: John A
authors.initials: JA
authors.lastname: Hansen
authors.affiliation: Division of Pediatric Stem Cell Transplantation and Regenerative Medicine, Stanford University, Palo Alto, California.
authors.forename: Robertson
authors.initials: R
authors.lastname: Parkman
authors.affiliation: Division of Blood and Marrow Transplantation, Stanford University, Palo Alto, California.
authors.forename: David B
authors.initials: DB
authors.lastname: Miklos
authors.affiliation: Division of Clinical Research, Fred Hutchinson Cancer Research Center, Department of Medicine, University of Washington, Seattle, Washington.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Martin
authors.affiliation: Departments of Pediatrics and Immunology, Wells Center for Pediatric Research, Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana.
authors.forename: Sophie
authors.initials: S
authors.lastname: Paczesny
authors.affiliation: Department of Oncology, Sidney Kimmel Cancer Center at Johns Hopkins Hospital, Baltimore, Maryland.
authors.forename: Georgia
authors.initials: G
authors.lastname: Vogelsang
authors.affiliation: Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
authors.forename: Steven
authors.initials: S
authors.lastname: Pavletic
authors.affiliation: Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
authors.forename: Jerome
authors.initials: J
authors.lastname: Ritz
authors.affiliation: Michael Cuccione Childhood Cancer Research Program, Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: kschultz@mail.ubc.ca.
authors.forename: Kirk R
authors.initials: KR
authors.lastname: Schultz
authors.affiliation: Masonic Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota. Electronic address: blaza001@umn.edu.
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Blazar
mesh_terms: D064591:Allografts; D000818:Animals; D015415:Biomarkers; D002908:Chronic Disease; D002986:Clinical Trials as Topic / Q000592:standards*; D016207:Cytokines / Q000378:metabolism; D004730:Endothelium, Vascular / Q000473:pathology; D005355:Fibrosis; D006086:Graft vs Host Disease / Q000209:etiology / Q000276:immunology / Q000473:pathology / Q000628:therapy; D006801:Humans; D007249:Inflammation; D007371:Interferon-gamma / Q000502:physiology; D051379:Mice; D023421:Models, Animal; D018448:Models, Immunological; D009928:Organ Specificity; D016176:T-Lymphocyte Subsets / Q000276:immunology; D009626:Terminology as Topic; D014181:Transplantation Immunology; D014945:Wound Healing
chemical_list: D015415:Biomarkers; D016207:Cytokines; D007371:Interferon-gamma
keywords: Blood and marrow transplantation; Chronic graft-versus-host disease; Clinical manifestations; Immune mechanisms