title: Novel Catalyst System for Suzuki-Miyaura Coupling of Challenging DNA-Linked Aryl Chlorides.
abstract: A novel Pd catalyst system, [(t-Bu)2P(OH)]2PdCl2(POPd) with the ligand sodium 2'-(dicyclohexylphosphino)-2,6-dimethoxy-[1,1'-biphenyl]-3-sulfonate, is reported. It effectively catalyzes the Suzuki-Miyaura coupling of challenging phenyl chlorides and pyrimidinyl chlorides that are covalently linked to a double-stranded DNA-template with various boronic acids/esters.
authors.affiliation: GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States.
authors.forename: Yun
authors.initials: Y
authors.lastname: Ding
authors.affiliation: GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: DeLorey
authors.affiliation: GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States.
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Clark
mesh_terms: D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D010165:Palladium / Q000737:chemistry*
chemical_list: D002712:Chlorides; D008024:Ligands; D010165:Palladium; D004247:DNA