title: A comparative assessment of the acute inhalation toxicity of vanadium compounds.
abstract: Vanadium compounds have become important in industrial processes, resulting in workplace exposure potential and are present in ambient air as a result of fossil fuel combustion. A series of acute nose-only inhalation toxicity studies was conducted in both rats and mice in order to obtain comparative data on the acute toxicity potential of compounds used commercially. V2O3, V2O4, and V2O5, which have different oxidation states (+3, +4, +5, respectively), were delivered as micronized powders; the highly water-soluble and hygroscopic VOSO4(+4) could not be micronized and was instead delivered as a liquid aerosol from an aqueous solution. V2O5was the most acutely toxic micronized powder in both species. Despite its lower overall percentage vanadium content, a liquid aerosol of VOSO4was more toxic than the V2O5particles in mice, but not in rats. These data suggest that an interaction of characteristics, i.e., bioavailability, solubility and oxidation state, as well as species sensitivity, likely affect the toxicity potential of vanadium compounds. Based on clinical observations and gross necropsy findings, the lung appeared to be the target organ for all compounds. The level of hazard posed will depend on the specific chemical form of the vanadium. Future work to define the inhalation toxicity potential of vanadium compounds of various oxidation states after repeated exposures will be important in understanding how the physico-chemical and biological characteristics of specific vanadium compounds interact to affect toxicity potential and the potential risks posed to human health.
authors.affiliation: a Life Sciences Group, IIT Research Institute , Chicago , IL , USA.
authors.forename: N
authors.initials: N
authors.lastname: Rajendran
authors.affiliation: b Applied Biomedical Research, Lovelace Respiratory Research Institute , Albuquerque , NM , USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Seagrave
authors.affiliation: c Integrative Biostrategies, LLC , Houston , TX , USA , and.
authors.forename: L M
authors.initials: LM
authors.lastname: Plunkett
authors.affiliation: d Toxicology Consulting Services , Bonita Springs , FL , USA.
authors.forename: J A
authors.initials: JA
authors.lastname: MacGregor
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D005260:Female; D008297:Male; D051379:Mice; D051381:Rats; D011916:Rats, Inbred F344; D012995:Solubility; D023382:Toxicity Tests, Acute; D017968:Vanadium Compounds / Q000737:chemistry / Q000633:toxicity*
chemical_list: D017968:Vanadium Compounds
keywords: Vanadium; in-vitro solubility; inhalation toxicity; metal toxicity