title: In vivo protective role against water contamination with cerium via chronic administration of omega 3.
abstract: In the present study, adult, healthy male Wistar rats (120 ± 10 g) were pre-treated by intragastric administration of cerium chloride (CeCl3) 10 mg/kg (BW) each day during 60 days. Control animal were treated with omega 3, a polyunsaturated fatty acid (ω-3), by an intragastric administration at 10 mg/kg of BW for 60 days. Our results showed that CeCl3-induced alterations in all tested oxidative stress markers. In fact, CeCl3-induced the increase the level of both the creatinine concentration and the expression of lactate dehydrogenase, alkaline phosphatase, and transaminase activities in serum. On the other hand, CeCl3significantly increased the levels of lipid peroxidation in the renal and hepatic tissues. The capacity of CeCl3to generate reactive oxygen species (ROS) could explain his ability to induce morphological alterations, such as centrilobular hemorrhage, hepatic necrosis, and vacuolization of the cytoplasm in hepatic tissues, and the atrophy of the glomerulus and dilatation of urinary space in renal tissues. However, omega 3, after gastric administration, reduced significantly the toxic effect caused by CeCl3according to his high ability to scavenge ROS. The present study indicates that omega 3 is a significant compound with protective activity against intoxication with heavy metal, the cerium, and thus may be useful for chemoprevention.
authors.affiliation: Unité de Biochimie Macromoléculaire et Génétique, Faculté des sciences de Gafsa, cité Zarroug, 2112, Gafsa, Tunisie.|Unité de recherche analyses et procédés appliquées à l'environnement Institut Supérieur des Sciences appliquées et de technologie de Mahdia, Université de Monastir, Monastir, Tunisie.
authors.forename: Asma
authors.initials: A
authors.lastname: Beltifa
authors.affiliation: Unité de Biochimie Macromoléculaire et Génétique, Faculté des sciences de Gafsa, cité Zarroug, 2112, Gafsa, Tunisie.
authors.forename: Mohamed Ali
authors.initials: MA
authors.lastname: Borgi
authors.affiliation: Faculté des Sciences de Sfax, Département des Sciences de la Vie, Laboratoire d'Eco Physiologie Animale, BP, 1171, Sfax, 3000, Tunisie.
authors.forename: Anouar
authors.initials: A
authors.lastname: Ferieni
authors.affiliation: Faculté des Sciences de Sfax, Département des Sciences de la Vie, Laboratoire d'Eco Physiologie Animale, BP, 1171, Sfax, 3000, Tunisie.
authors.forename: Abdelfettah
authors.initials: A
authors.lastname: Elfekih
authors.affiliation: Unité de recherche analyses et procédés appliquées à l'environnement Institut Supérieur des Sciences appliquées et de technologie de Mahdia, Université de Monastir, Monastir, Tunisie.
authors.forename: Hedi Ben
authors.initials: HB
authors.lastname: Mansour
authors.affiliation: Faculté des Sciences de Sfax, Département des Sciences de la Vie, Laboratoire d'Eco Physiologie Animale, BP, 1171, Sfax, 3000, Tunisie. amsallagui@yahoo.fr.
authors.forename: Mohamed Sallah
authors.initials: MS
authors.lastname: Allagui
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002563:Cerium / Q000494:pharmacology*; D003404:Creatinine / Q000097:blood; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D007668:Kidney / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D020011:Protective Agents / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000494:pharmacology*
chemical_list: D015415:Biomarkers; D015525:Fatty Acids, Omega-3; D020011:Protective Agents; D017382:Reactive Oxygen Species; D014874:Water Pollutants, Chemical; D002563:Cerium; D003404:Creatinine
keywords: Heavy metal; Hepatic and renal toxicities; Omega 3; Protective effect; Reactive oxygen species