title: Association between miR-137 polymorphism and risk of schizophrenia: a meta-analysis.
abstract: miR-137, a brain-enriched microRNA, is involved in the control of neuronal proliferation, differentiation, and dendritic arborization, all of which are important for proper neurogenesis and relevant to schizophrenia. miR-137 is also known to regulate many genes implicated in schizophrenia risk. Although reports have associated the miR-137 polymorphism rs1625579 with this disease, their results have been inconsistent. The aim of this meta-analysis was to evaluate the relationship between rs1625579 and schizophrenia. Data were obtained from an electronic database, and pooled odds ratios (ORs) with 95% confidence intervals (95%CI) were used to test the association using the RevMan 5.3 software. Twelve case-control studies comprising 11,583 cases and 14,315 controls were included. An estimated lambda value of 0.46 was recorded, suggesting that a codominant model of inheritance was most likely. A statistically significant association was established under allelic (T vs G: OR = 1.15, 95%CI = 1.10-1.21, P < 0.001) and homogeneous codominant models (TT vs GG: OR = 1.32, 95%CI = 1.13-1.54, P < 0.001), but no such relationship was detected using the heterogeneous codominant model (GT vs GG: OR = 1.14, 95%CI = 0.97-1.34, P = 0.11). This meta-analysis demonstrates that the rs1625579 miR-137 genetic variant significantly increases schizophrenia risk.
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.|Department of Parasitology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
authors.forename: M L
authors.initials: ML
authors.lastname: Ou
authors.affiliation: Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong, China.
authors.forename: G
authors.initials: G
authors.lastname: Liu
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
authors.forename: D
authors.initials: D
authors.lastname: Xiao
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
authors.forename: B H
authors.initials: BH
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
authors.forename: C C
authors.initials: CC
authors.lastname: Guo
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
authors.forename: X G
authors.initials: XG
authors.lastname: Ye
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
authors.forename: N
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
authors.forename: M
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Han
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
authors.forename: X H
authors.initials: XH
authors.lastname: Ye
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.|Key Laboratory of Environmental Exposure and Health in Guangzhou, Jinan University, Guangzhou, Guangdong, China.
authors.forename: C X
authors.initials: CX
authors.lastname: Jing
authors.affiliation: Department of Parasitology, School of Medicine, Jinan University, Guangzhou, Guangdong, China guangyangphd@gmail.com.|Key Laboratory of Environmental Exposure and Health in Guangzhou, Jinan University, Guangzhou, Guangdong, China guangyangphd@gmail.com.
authors.forename: G
authors.initials: G
authors.lastname: Yang
mesh_terms: D000483:Alleles; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics* / Q000473:pathology
chemical_list: C545567:MIRN137 microRNA, human; D035683:MicroRNAs