title: Evaluation of liver fibrosis: "Something old, something new…".
abstract: Hepatic fibrogenesis may gradually result to cirrhosis due to the accumulation of extracellular matrix components as a response to liver injury. Thus, therapeutic decisions in chronic liver disease, regardless of the cause, should first and foremost be guided by an accurate quantification of hepatic fibrosis. Detection and assessment of the extent of hepatic fibrosis represent a challenge in modern Hepatology. Although traditional histological staging systems remain the "best standard", they are not able to quantify liver fibrosis as a dynamic process and may not accurately substage cirrhosis. This review aims to compare the currently used non-invasive methods of measuring liver fibrosis and provide an update in current tissue-based digital techniques developed for this purpose, that may prove of value in daily clinical practice.
authors.affiliation: Department of Pathology, Sismanoglio Hospital, Athens, Greece (Zannis Almpanis, Maria Demonakou).
authors.forename: Zannis
authors.initials: Z
authors.lastname: Almpanis
authors.affiliation: Department of Pathology, Sismanoglio Hospital, Athens, Greece (Zannis Almpanis, Maria Demonakou).
authors.forename: Maria
authors.initials: M
authors.lastname: Demonakou
authors.affiliation: Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon UK (Dina Tiniakos); Laboratory of Histology-Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece (Dina Tiniakos).
authors.forename: Dina
authors.initials: D
authors.lastname: Tiniakos
keywords: Non-invasive; digital; hepatic fibrosis; histology; staging