title: Generalized Seizures after Experimental Traumatic Brain Injury Occur at the Transition from Slow-Wave to Rapid Eye Movement Sleep.
abstract: Sleep disturbances commonly occur after traumatic brain injury (TBI) and may predispose patients to epileptic seizures. We hypothesized that unprovoked seizure occurrence post-TBI depends on the sleep-wake cycle, and that the electrographic characteristics of a given sleep stage provide biomarkers for post-traumatic epilepsy (PTE). We show, in a rat lateral fluid percussion model, that 92% of spontaneous generalized seizures occur during the transition from stage III to rapid eye movement sleep. Moreover, a reduction in spindle duration and dominant frequency during the transition stage present as specific and sensitive noninvasive biomarkers for experimentally induced PTE with generalized electrographic seizures.
authors.affiliation: Department of Neurobiology, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland , Kuopio, Finland .
authors.forename: Pedro
authors.initials: P
authors.lastname: Andrade
authors.affiliation: Department of Neurobiology, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland , Kuopio, Finland .
authors.forename: Jari
authors.initials: J
authors.lastname: Nissinen
authors.affiliation: Department of Neurobiology, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland , Kuopio, Finland .
authors.forename: Asla
authors.initials: A
authors.lastname: Pitkänen
mesh_terms: D000818:Animals; D000070642:Brain Injuries, Traumatic / Q000150:complications / Q000503:physiopathology*; D004195:Disease Models, Animal; D004834:Epilepsy, Post-Traumatic / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012894:Sleep Stages / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000209:etiology / Q000503:physiopathology*; D012895:Sleep, REM / Q000502:physiology
keywords: epilepsy; lateral fluid percussion; paradoxical sleep; post-traumatic epilepsy; rat