title: IL-2 and polyoma BK virus infection; A systematic review article.
abstract: It has been demonstrated that IL-2 plays a dual role in induction/suppression of immune responses via activation of conventional and regulatory T lymphocytes, respectively. IL-2 contacts complete IL-2 receptor (IL-2R) which contains CD25 (α chain) on the antigen specific activated T helper and cytotoxic lymphocytes and also T regulatory cells. Additionally, previous investigations revealed that polyoma BK virus (PBK) reactivation and induction of PBK associated nephropathy (PBKAN) is a main complication following renal transplantation. Based on the important dual roles played by IL-2 in the immune responses, it may be hypothesized that IL-2/IL-2R interaction could be considered a potential mechanism against/toward PBK reactivation and also PBKAN. Accordingly, the aim of the current review article is to determine the roles of IL-2 IL-2/IL-2R interaction in PBK reactivation and PBKAN complications.
authors.affiliation: Department of Microbiology, Kerman Branch, Islamic Azad University, Kerman, Iran. Electronic address: a.kariminik@iauk.ac.ir.
authors.forename: Ashraf
authors.initials: A
authors.lastname: Kariminik
mesh_terms: D000818:Animals; D001739:BK Virus / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007376:Interleukin-2 / Q000276:immunology*; D053645:Interleukin-2 Receptor alpha Subunit / Q000276:immunology; D007674:Kidney Diseases / Q000276:immunology* / Q000473:pathology / Q000821:virology; D027601:Polyomavirus Infections / Q000276:immunology* / Q000473:pathology; D015375:Receptors, Interleukin-2 / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000473:pathology; D014412:Tumor Virus Infections / Q000276:immunology* / Q000473:pathology
chemical_list: C508594:IL2 protein, human; C508017:IL2RA protein, human; D007376:Interleukin-2; D053645:Interleukin-2 Receptor alpha Subunit; D015375:Receptors, Interleukin-2
keywords: CD25; IL-2; IL-2 receptor; Polyoma BK associated nephropathy; Polyoma BK virus