title: Meroterpenoids and Chalcone-Lignoids from the Roots of Mimosa diplotricha.
abstract: Six new meroterpenoids, diplomeroterpenoids A-F (1-6), two new chalcone-lignoids, diplochalcolins A and B (7, 8), and 13 known compounds were isolated from the root extract of Mimosa diplotricha. Diplomeroterpenoids A-F consist of a 4H-chromen-4-one and a diterpenoid unit, and their absolute configurations were determined by X-ray crystallographic analysis. Compounds 1-3 and 5 showed potent inhibitory activity on protein farnesyl transferase, with IC50values from 5.0 to 8.5 μM. Compound 1 showed antiproliferative activity against human hepatoblastoma HepG2 cells with a GI50value of approximately 8.6 μM.
authors.affiliation: National Research Institute of Chinese Medicine , Ministry of Health and Welfare, Taipei, Taiwan.
authors.forename: Chun-Tang
authors.initials: CT
authors.lastname: Chiou
authors.affiliation: National Research Institute of Chinese Medicine , Ministry of Health and Welfare, Taipei, Taiwan.
authors.forename: Chien-Chang
authors.initials: CC
authors.lastname: Shen
authors.affiliation: Institute of Traditional Medicine, National Yang-Ming University , Taipei, Taiwan.
authors.forename: Tung-Hu
authors.initials: TH
authors.lastname: Tsai
authors.affiliation: Department of Radiation Oncology, Center of Biomedical Development, and Laboratory of Cancer Therapeutics, MacKay Memorial Hospital , Taipei, Taiwan.
authors.forename: Yu-Jen
authors.initials: YJ
authors.lastname: Chen
authors.affiliation: National Research Institute of Chinese Medicine , Ministry of Health and Welfare, Taipei, Taiwan.|Graduate Institute of Integrated Medicine, China Medical University , Taichung, Taiwan.
authors.forename: Lie-Chwen
authors.initials: LC
authors.lastname: Lin
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002599:Chalcone / Q000737:chemistry / Q000302:isolation & purification*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D031298:Mimosa / Q000737:chemistry*; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D013624:Taiwan; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D013729:Terpenes; D002599:Chalcone