title: Novel variants of mitochondrial DNA associated with Type 2 diabetes mellitus in Moroccan population.
abstract: In this study, we investigated the association of mtDNA variants and haplogroups with Type 2 diabetes (T2D) in Moroccan patients. The Hypervariable Segments 1 of the mtDNA was sequenced in 108 diabetic patients and 97 controls. Association analyses were performed using Fisher's exact test and multivariate logistic regression. The prevalence of five mtDNA variants (C16187T, C16270T, T16172C, A16293G, and C16320T) was significantly higher in cases than in controls. Among these variants, only C16270T (p = .02) and C16320T (p = .03) remains significant after adjusting by age and gender. We showed that C16270T and C16320T variants were strongly associated with increased risk of T2D in Moroccan patients.
authors.affiliation: a Institut Pasteur, Human Molecular Genetic Laboratory , Casablanca , Morocco.
authors.forename: Hicham
authors.initials: H
authors.lastname: Charoute
authors.affiliation: b Biomedical Genomics and Oncogenetics Laboratory (LR 11 IPT 05) , Institut Pasteur de Tunis, Université de Tunis El Manar , Tunis , Tunisia.
authors.forename: Rym
authors.initials: R
authors.lastname: Kefi
authors.affiliation: a Institut Pasteur, Human Molecular Genetic Laboratory , Casablanca , Morocco.
authors.forename: Safaa
authors.initials: S
authors.lastname: Bounaceur
authors.affiliation: a Institut Pasteur, Human Molecular Genetic Laboratory , Casablanca , Morocco.
authors.forename: Houda
authors.initials: H
authors.lastname: Benrahma
authors.affiliation: a Institut Pasteur, Human Molecular Genetic Laboratory , Casablanca , Morocco.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Reguig
authors.affiliation: c Equipe d'Anthropogénétique et Biotechnologies, Faculté des Sciences , Université Chouaïb Doukkali , El Jadida , Morocco.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Kandil
authors.affiliation: a Institut Pasteur, Human Molecular Genetic Laboratory , Casablanca , Morocco.
authors.forename: Hassan
authors.initials: H
authors.lastname: Rouba
authors.affiliation: a Institut Pasteur, Human Molecular Genetic Laboratory , Casablanca , Morocco.
authors.forename: Amina
authors.initials: A
authors.lastname: Bakhchane
authors.affiliation: b Biomedical Genomics and Oncogenetics Laboratory (LR 11 IPT 05) , Institut Pasteur de Tunis, Université de Tunis El Manar , Tunis , Tunisia.
authors.forename: Sonia
authors.initials: S
authors.lastname: Abdelhak
authors.affiliation: a Institut Pasteur, Human Molecular Genetic Laboratory , Casablanca , Morocco.
authors.forename: Abdelhamid
authors.initials: A
authors.lastname: Barakat
mesh_terms: D000368:Aged; D004272:DNA, Mitochondrial; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D054629:Genome, Mitochondrial; D006801:Humans; D008297:Male; D008875:Middle Aged; D009018:Morocco; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA
chemical_list: D004272:DNA, Mitochondrial
keywords: Mitochondria; Type 2 diabetes; genetic association; hypervariable segment 1; mitochondrial variant