title: Structural Characterization and Assessment of the Cytotoxicity of 2,3-Dihydro-1H-indene Derivatives and Coumarin Glucosides from the Bark of Streblus indicus.
abstract: A pair of enantiomers and a pair of 2,3-dihydro-1H-indene epimers, rac-indidene A (rac-1), indidenes B and C (2, 3); four new coumarin glucosides (4-7); and four known coumarin glucosides (8-11) were isolated from the bark of Streblus indicus (Bur.) Corner. The structures of 1-11 were defined by physical data analyses, including MS, NMR, and single-crystal X-ray diffraction. The absolute configurations of the 2,3-dihydro-1H-indene derivatives were defined via experimental and calculated ECD data. rac-Indidene A and indidenes B and C showed inhibitory activity against A549 and MCF-7 tumor cells with IC50values in the range of 2.2 ± 0.1 to 7.2 ± 0.9 μM.
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy, Guangxi Normal University , Guilin 541004, People's Republic of China.|Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany , Guilin 541006, People's Republic of China.
authors.forename: Ruijie
authors.initials: R
authors.lastname: He
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University , Guangzhou 510275, People's Republic of China.
authors.forename: Xishan
authors.initials: X
authors.lastname: Huang
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy, Guangxi Normal University , Guilin 541004, People's Republic of China.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy, Guangxi Normal University , Guilin 541004, People's Republic of China.
authors.forename: Liangdeng
authors.initials: L
authors.lastname: Wu
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy, Guangxi Normal University , Guilin 541004, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Nie
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy, Guangxi Normal University , Guilin 541004, People's Republic of China.
authors.forename: Dexiong
authors.initials: D
authors.lastname: Zhou
authors.affiliation: Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards , Nanning 530022, People's Republic of China.
authors.forename: Buming
authors.initials: B
authors.lastname: Liu
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy, Guangxi Normal University , Guilin 541004, People's Republic of China.
authors.forename: Shengping
authors.initials: S
authors.lastname: Deng
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy, Guangxi Normal University , Guilin 541004, People's Republic of China.
authors.forename: Ruiyun
authors.initials: R
authors.lastname: Yang
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy, Guangxi Normal University , Guilin 541004, People's Republic of China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Huang
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy, Guangxi Normal University , Guilin 541004, People's Republic of China.
authors.forename: Zhijie
authors.initials: Z
authors.lastname: Nong
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy, Guangxi Normal University , Guilin 541004, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards , Nanning 530022, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000072283:A549 Cells; D002851:Chromatography, High Pressure Liquid; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D007192:Indenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D015394:Molecular Structure; D029586:Moraceae / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D003374:Coumarins; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D007192:Indenes