title: [Comparative results of use liver protecting drugs for prophylaxis of the liver failure after extensive resections of the liver].
abstract: After 100 extensive resections of a liver for excision of metastasises of a colorectal cancer, the different drugs protecting a liver were used for prophylaxis of a liver failure.
  
  
  METHODS
  Patients were distributed on 2 equivalent groups. Patients of the first group received Ademetionin in a dosage 400 mg 2 times a day within 7 days. Patients of the second group received Remaxol in a dosage 400 ml within 7 days once a day.
  
  
  RESULTS
  Frequency of cases of an acute liver failure in the first group of patients was 38%, in the second group of patients - 20% (p<0.05). Patients of the second group had milder course of an acute liver failure (by criteria of ISGLS, 2011) in comparison with patients of the first group. Postoperative bed - days in the first group of patients lasted 13 (11-15) days, in the second group of patients - 11 (10-13) days (p<0.05). There was no postoperative lethality.
authors.affiliation: State Research Center of the Russian Federation - Burnazyan Federal Medical Biophysical Center, FMBA of Russia, Moscow, Russia.
authors.forename: S E
authors.initials: SE
authors.lastname: Voskanyan
authors.affiliation: State Research Center of the Russian Federation - Burnazyan Federal Medical Biophysical Center, FMBA of Russia, Moscow, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Naidyonov
authors.affiliation: State Research Center of the Russian Federation - Burnazyan Federal Medical Biophysical Center, FMBA of Russia, Moscow, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Artemyev
authors.affiliation: State Research Center of the Russian Federation - Burnazyan Federal Medical Biophysical Center, FMBA of Russia, Moscow, Russia.
authors.forename: D A
authors.initials: DA
authors.lastname: Zabezhinsky
authors.affiliation: State Research Center of the Russian Federation - Burnazyan Federal Medical Biophysical Center, FMBA of Russia, Moscow, Russia.
authors.forename: V S
authors.initials: VS
authors.lastname: Rudakov
authors.affiliation: State Research Center of the Russian Federation - Burnazyan Federal Medical Biophysical Center, FMBA of Russia, Moscow, Russia.
authors.forename: A S
authors.initials: AS
authors.lastname: Zhurbin
authors.affiliation: State Research Center of the Russian Federation - Burnazyan Federal Medical Biophysical Center, FMBA of Russia, Moscow, Russia.
authors.forename: A N
authors.initials: AN
authors.lastname: Bashkov
authors.affiliation: State Research Center of the Russian Federation - Burnazyan Federal Medical Biophysical Center, FMBA of Russia, Moscow, Russia.
authors.forename: O O
authors.initials: OO
authors.lastname: Grigorieva
mesh_terms: D018890:Chemoprevention / Q000379:methods; D015179:Colorectal Neoplasms / Q000473:pathology*; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects / Q000379:methods; D006801:Humans; D007902:Length of Stay; D017093:Liver Failure / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D008111:Liver Function Tests / Q000379:methods; D008113:Liver Neoplasms / Q000556:secondary / Q000601:surgery; D008297:Male; D008875:Middle Aged; D020011:Protective Agents / Q000008:administration & dosage; D012436:S-Adenosylmethionine / Q000008:administration & dosage*; D013386:Succinates / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D020011:Protective Agents; C555877:Remaxol; D013386:Succinates; D012436:S-Adenosylmethionine