title: The Association Between Bone Mineral Density and Airflow Limitation in a Cohort of Fit Elderly Women.
abstract: As studies examining the association between bone mineral density (BMD) and airflow limitation (AL) have produced conflicting results, the current one set out to analyze if and to what degree there are any correlations between these variables in a population of fit elderly women.
  
  
  
  One hundred and twenty-one non-smoking, fit and healthy women (age ≥ 65 years) underwent anthropometric assessment, laboratory testing (serum 25-hydroxy vitamin D, parathormone, and cytokine levels), pulmonary function testing (PFT), and dual-energy X-ray absorptiometry to evaluate BMD values of the lumbar and femoral regions.
  
  
  
  A significant positive association was found between FEV1/FVC ratio (Tiffeneau index), a sensitive index of AL, and lumbar and femoral BMD; a 10 % increase in the FEV1/FVC ratio resulted in a significant increase of 0.025 g/cm2in the total hip (p = 0.05), 0.027 g/cm2in the femoral neck (p = 0.02), 0.028 g/cm2in the femoral trochanter (p = 0.01), and 0.047 g/cm2in the lumbar (p = 0.03) BMDs. Binary logistic analyses demonstrated more than a threefold higher risk of low BMD values for the lowest FEV1/FVC quartile in the lumbar (OR 4.62, 95 % CI 1.48-14.40, p = 0.008), total hip (OR 4.09, 95 % CI 1.28-13.05, p = 0.02 for the second quartile), and femoral trochanter regions (OR 3.90, 95 % CI 1.25-12.20, p = 0.02 for the third quartile).
  
  
  
  AL was associated with a higher risk of reduced BMD in healthy, fit elderly women.
authors.affiliation: Geriatrics Division, Department of Medicine (DIMED), University of Padova, Via Giustiniani 2, 35128, Padua, Italy. skicateg@libero.it.
authors.forename: Caterina
authors.initials: C
authors.lastname: Trevisan
authors.affiliation: Respiratory Pathophysiology Division, University of Padova, Padua, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Vianello
authors.affiliation: Geriatrics Division, Department of Medicine (DIMED), University of Padova, Via Giustiniani 2, 35128, Padua, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Veronese
authors.affiliation: Geriatrics Division, Department of Medicine (DIMED), University of Padova, Via Giustiniani 2, 35128, Padua, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Carraro
authors.affiliation: Geriatrics Division, Department of Medicine (DIMED), University of Padova, Via Giustiniani 2, 35128, Padua, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Pizzato
authors.affiliation: Geriatrics Division, Department of Medicine (DIMED), University of Padova, Via Giustiniani 2, 35128, Padua, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Lucato
authors.affiliation: Geriatrics Division, Department of Medicine (DIMED), University of Padova, Via Giustiniani 2, 35128, Padua, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Girotti
authors.affiliation: Respiratory Pathophysiology Division, University of Padova, Padua, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Rinaldo
authors.affiliation: Geriatrics Division, Department of Medicine (DIMED), University of Padova, Via Giustiniani 2, 35128, Padua, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Coin
authors.affiliation: Geriatrics Division, Department of Medicine (DIMED), University of Padova, Via Giustiniani 2, 35128, Padua, Italy.|National Research Council, Neuroscience Institute, Padua, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Manzato
authors.affiliation: Geriatrics Division, Department of Medicine (DIMED), University of Padova, Via Giustiniani 2, 35128, Padua, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Sergi
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D015519:Bone Density; D005260:Female; D005272:Femur Neck / Q000000981:diagnostic imaging*; D005541:Forced Expiratory Volume; D064368:Healthy Volunteers; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging*; D010809:Physical Fitness / Q000502:physiology*; D014797:Vital Capacity
keywords: Airflow limitation; Bone mineral density; Elderly; Pulmonary function test