title: Palladium meets copper: one-pot tandem synthesis of pyrido fused heterocycles via Sonogashira conjoined electrophilic cyclization.
abstract: An efficient step-economical tandem approach for the direct synthesis of pyrido fused indole, quinoline, benzofuran and benzothiophene derivatives using a bimetallic Pd/Cu catalytic system has been described. The three component reaction of o-halo aldehydes, alkynes and tert-butylamine leads to the synthesis of biologically active polyheterocycles. The present strategy involves the dual role of tert-butylamine and copper(i) in Sonogashira coupling followed by electrophilic cyclization through imine formation. The chemistry has been validated by X-ray crystallographic studies.
authors.affiliation: Synthetic Organic Chemistry Research Laboratory, Department of Chemistry, University of Delhi, Delhi - 110007, India. averma@acbr.du.ac.in.
authors.forename: Sonu
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Synthetic Organic Chemistry Research Laboratory, Department of Chemistry, University of Delhi, Delhi - 110007, India. averma@acbr.du.ac.in.
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Saunthwal
authors.affiliation: Synthetic Organic Chemistry Research Laboratory, Department of Chemistry, University of Delhi, Delhi - 110007, India. averma@acbr.du.ac.in.
authors.forename: Trapti
authors.initials: T
authors.lastname: Aggarwal
authors.affiliation: Synthetic Organic Chemistry Research Laboratory, Department of Chemistry, University of Delhi, Delhi - 110007, India. averma@acbr.du.ac.in.
authors.forename: Siva K Reddy
authors.initials: SK
authors.lastname: Kotla
authors.affiliation: Synthetic Organic Chemistry Research Laboratory, Department of Chemistry, University of Delhi, Delhi - 110007, India. averma@acbr.du.ac.in.
authors.forename: Akhilesh K
authors.initials: AK
authors.lastname: Verma