title: Intramolecular thermal stepwise [2 + 2] cycloadditions: investigation of a stereoselective synthesis of [n.2.0]-bicyclolactones.
abstract: Fused cyclobutanes are found in a range of natural products and formation of these motifs in a straightforward and easy manner represents an interesting synthetic challenge. To this end we investigated an intramolecular variant of the thermal enamine [2 + 2] cyclisation, developing a diastereoselective intramolecular enamine [2 + 2] cyclisation furnishing δ lactone and lactam fused cyclobutenes in good yield and excellent diastereoselectivity.
authors.affiliation: Institute of Cancer Therapeutics, University of Bradford, Bradford, BD7 1DP, UK. h.sheldrake@bradford.ac.uk.
authors.forename: Adam
authors.initials: A
authors.lastname: Throup
authors.affiliation: Institute of Cancer Therapeutics, University of Bradford, Bradford, BD7 1DP, UK. h.sheldrake@bradford.ac.uk.
authors.forename: Laurence H
authors.initials: LH
authors.lastname: Patterson
authors.affiliation: Institute of Cancer Therapeutics, University of Bradford, Bradford, BD7 1DP, UK. h.sheldrake@bradford.ac.uk.
authors.forename: Helen M
authors.identifier: http://orcid.org/0000-0003-4111-2132
authors.initials: HM
authors.lastname: Sheldrake