title: Dopamine DRD2 polymorphism (DRD2/ANNK1-Taq1A) is not a significant risk factor in writer's cramp.
abstract: Writers' cramp is a movement disorder with dystonic co-contraction of fingers and hand during writing and is part of the clinical spectrum of focal dystonias. Previous studies showed reduced striatal dopamine receptor D2 (DRD2) availability in dystonia. The expression of D2 receptors is modulated by a DRD2/ANKK1-Taq1A polymorphism (rs1800497). This study addresses the question of whether the DRD2/ANKK1-Taq1A polymorphism is a risk factor for writer's cramp. We determined the DRD2/ANKK1-Taq1A polymorphism 34 patients with writer's cramp compared to 67 age matched controls. 35.3% of the patients and 31.3% of our controls were assigned to the A1 genotype status (p = .7). Therefore DRD2/ANKK1-Taq1A gene is not a significant risk factor in the evolution of writer's cramp.
authors.affiliation: a Department of Neurology , University of Kiel , Germany.
authors.forename: Kirsten E
authors.initials: KE
authors.lastname: Zeuner
authors.affiliation: b First Department of Neurology , Institute of Psychiatry and Neurology , Warsaw , Poland.
authors.forename: Albert
authors.initials: A
authors.lastname: Acewicz
authors.affiliation: a Department of Neurology , University of Kiel , Germany.
authors.forename: Arne
authors.initials: A
authors.lastname: Knutzen
authors.affiliation: c Department of Neurology, Movement Disorders Section , Hannover Medical School , Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Dressler
authors.affiliation: d Institute of Neurogenetics, University of Lübeck , Lübeck , Germany.
authors.forename: Katja
authors.initials: K
authors.lastname: Lohmann
authors.affiliation: a Department of Neurology , University of Kiel , Germany.
authors.forename: Karsten
authors.initials: K
authors.lastname: Witt
mesh_terms: D000328:Adult; D000368:Aged; D020821:Dystonic Disorders / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012307:Risk Factors
chemical_list: C581293:DRD2 protein, human; D017448:Receptors, Dopamine D2
keywords: Basal ganglia; DRD2/ANNK1-Taq1A; Writer’s cramp; genetics; task specific dystonia