title: [Cross sectional study of comorbidities and concomitant medications in a cohort of human immunodeficiency virus-infected patients].
abstract: OBJECTIVE
  To assess the prevalence of comorbidities, concomitant therapies and adverse effects associated with the medication in a cohort of patients with HIV infection.
  
  
  METHODS
  Multicentre cross-sectional study.
  
  
  METHODS
  Infectious Diseases or Internal Medicine outpatient Clinics of 3 hospitals in the Basque Country.
  
  
  METHODS
  During a 3 month period, patients with the following inclusion criteria were randomly selected: HIV infection, age>18years, antiretroviral treatment (ART) for at least 6months, and no changes in ART in the previous 4weeks. A total of 224 patients (of the 225 expected) were included.
  
  
  METHODS
  Data were collected using a form, and include, epidemiological and anthropometric data, data related to HIV infection, comorbidities, current therapies, and adverse effects.
  
  
  RESULTS
  Of the 224 patients, 95.5% had at least one comorbidity, the most common being HCV infection (51.3%), dyslipidaemia (37.9%), diabetes mellitus or impaired fasting glucose (21.9%), and hypertension (21.9%). A total of 155 patients (69.2%) were taking concomitant medication: anxiolytics (21.4%), antihypertensives (19.6%), proton pump inhibitors (17.9%), statins (17%), and antidepressants (16.5%). Adverse effects (AE) were observed in 62.9% of subjects, the most common being, changes in body fat distribution (32.6%) and gastrointestinal (24.1%).
  
  
  CONCLUSIONS
  Patients with HIV infection are getting older, with more comorbidities, with very frequent use of concomitant treatments, and high number of adverse effects. This requires a multidisciplinary approach and a coordinated effort within the Primary Care setting.
authors.affiliation: Servicio de Enfermedades Infecciosas, Hospital Galdakao, Usansolo, Bizcaia, España.
authors.forename: Maria Asunción
authors.initials: MA
authors.lastname: García Gonzalo
authors.affiliation: Servicio de Medicina Interna, Hospital Universitario de Araba, Vitoria-Gasteiz, Álava, España.
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Santamaría Mas
authors.affiliation: Servicio de Enfermedades Infecciosas, Hospital Universitario Donostia, San Sebastián-Donostia, Gipuzkoa, España.
authors.forename: Lidia
authors.initials: L
authors.lastname: Pascual Tomé
authors.affiliation: Servicio de Enfermedades Infecciosas, Hospital Universitario Donostia, San Sebastián-Donostia, Gipuzkoa, España.
authors.forename: Maialen
authors.initials: M
authors.lastname: Ibarguren Pinilla
authors.affiliation: Servicio de Enfermedades Infecciosas, Hospital Universitario Donostia, San Sebastián-Donostia, Gipuzkoa, España. Electronic address: francisco.rodriguezarrondo@osakidetza.eus.
authors.forename: Francisco
authors.initials: F
authors.lastname: Rodríguez-Arrondo
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019338:Polypharmacy; D055815:Young Adult
keywords: Antiretroviral therapy; Comorbidity; Comorbilidades; Concomitant medications; Human immunodeficiency virus; Tratamiento antirretroviral; Tratamientos concomitantes; Virus de la inmunodeficiencia humana