title: PAI: Predicting adenosine to inosine editing sites by using pseudo nucleotide compositions.
abstract: The adenosine to inosine (A-to-I) editing is the most prevalent kind of RNA editing and involves in many biological processes. Accurate identification of A-to-I editing site is invaluable for better understanding its biological functions. Due to the limitations of experimental methods, in the present study, a support vector machine based-model, called PAI, is proposed to identify A-to-I editing site in D. melanogaster. In this model, RNA sequences are encoded by "pseudo dinucleotide composition" into which six RNA physiochemical properties were incorporated. PAI achieves promising performances in jackknife test and independent dataset test, indicating that it holds very high potential to become a useful tool for identifying A-to-I editing site. For the convenience of experimental scientists, a web-server was constructed for PAI and it is freely accessible at http://lin.uestc.edu.cn/server/PAI.
authors.affiliation: Department of Physics, School of Sciences, and Center for Genomics and Computational Biology, North China University of Science and Technology, Tangshan, 063000, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: School of Public Health, North China University of Science and Technology, Tangshan, 063000, China.
authors.forename: Pengmian
authors.initials: P
authors.lastname: Feng
authors.affiliation: Key Laboratory for Neuro-Information of Ministry of Education, School of Life Science and Technology, Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Ding
authors.affiliation: Key Laboratory for Neuro-Information of Ministry of Education, School of Life Science and Technology, Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Lin
mesh_terms: D000241:Adenosine / Q000378:metabolism*; D000818:Animals; D004331:Drosophila melanogaster / Q000235:genetics* / Q000378:metabolism*; D004772:Entomology / Q000379:methods; D007288:Inosine / Q000378:metabolism*; D008967:Molecular Biology / Q000379:methods*; D009711:Nucleotides / Q000378:metabolism*; D017393:RNA Editing
chemical_list: D009711:Nucleotides; D007288:Inosine; D000241:Adenosine