title: A Comparison of Oxycodone and Alfentanil in Intravenous Patient-Controlled Analgesia with a Time-Scheduled Decremental Infusion after Laparoscopic Cholecystectomy.
abstract: Background. Oxycodone, a semisynthetic opioid, has been widely used for acute and chronic pain.Objectives. The aim of this study was to compare the analgesic and adverse effects of oxycodone and alfentanil on postoperative pain after laparoscopic cholecystectomy.Methods. This was a prospective, randomized, double-blind study. A total of 82 patients undergoing laparoscopic cholecystectomy were randomly assigned to receive either oxycodone or alfentanil using intravenous patient-controlled analgesia (PCA). PCA was administered as a time-scheduled decremental continuous infusion based on lean body mass for 48 hours postoperatively. Patients were assessed for pain with a visual analogue scale (VAS), the cumulative PCA dose, adverse effects, sedation level at 1, 4, 8, 16, 24, and 48 hours postoperatively, and satisfaction during the postoperative 48 hours.Results. There were no significant differences (p< 0.05) between the two groups in VAS score, cumulative PCA dose, adverse effects, sedation level at 1, 4, 8, 16, 24, and 48 hours postoperatively, and satisfaction during the postoperative 48 hours.Conclusions. Our data showed that the analgesic and adverse effects of oxycodone and alfentanil were similar. Therefore, oxycodone may be a good alternative to alfentanil for pain management using intravenous PCA after laparoscopic cholecystectomy when used at a conversion ratio of 10 : 1. This trial is registered with KCT0001962.
authors.affiliation: Department of Anesthesiology and Pain Medicine, College of Medicine, Hallym University, Chuncheon Sacred Heart Hospital, Chuncheon, Republic of Korea.
authors.forename: Young Suk
authors.identifier: 0000-0001-7753-8464
authors.initials: YS
authors.lastname: Kwon
authors.affiliation: Department of Anesthesiology and Pain Medicine, College of Medicine, Hallym University, Chuncheon Sacred Heart Hospital, Chuncheon, Republic of Korea.
authors.forename: Ji Su
authors.initials: JS
authors.lastname: Jang
authors.affiliation: Department of Anesthesiology and Pain Medicine, College of Medicine, Hallym University, Chuncheon Sacred Heart Hospital, Chuncheon, Republic of Korea.
authors.forename: Na Rea
authors.identifier: 0000-0002-3640-5523
authors.initials: NR
authors.lastname: Lee
authors.affiliation: Department of Anesthesiology and Pain Medicine, College of Medicine, University of Ulsan, Gangneung Asan Hospital, Gangneung, Republic of Korea.
authors.forename: Seong Su
authors.initials: SS
authors.lastname: Kim
authors.affiliation: Department of Anesthesiology and Pain Medicine, College of Medicine, University of Ulsan, Gangneung Asan Hospital, Gangneung, Republic of Korea.
authors.forename: Young Ki
authors.initials: YK
authors.lastname: Kim
authors.affiliation: Department of Anesthesiology and Pain Medicine, College of Medicine, Kangwon National University, Kangwon National University Hospital, Chuncheon, Republic of Korea.
authors.forename: Byeong Mun
authors.initials: BM
authors.lastname: Hwang
authors.affiliation: Department of Anesthesiology and Pain Medicine, College of Medicine, Kangwon National University, Kangwon National University Hospital, Chuncheon, Republic of Korea.
authors.forename: Seong Sik
authors.initials: SS
authors.lastname: Kang
authors.affiliation: Department of Anesthesiology and Pain Medicine, College of Medicine, Kangwon National University, Kangwon National University Hospital, Chuncheon, Republic of Korea.
authors.forename: Hee Jeong
authors.initials: HJ
authors.lastname: Son
authors.affiliation: Department of Anesthesiology and Pain Medicine, College of Medicine, Hallym University, Chuncheon Sacred Heart Hospital, Chuncheon, Republic of Korea.
authors.forename: So Young
authors.identifier: 0000-0003-0598-4574
authors.initials: SY
authors.lastname: Lim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015760:Alfentanil / Q000008:administration & dosage*; D016058:Analgesia, Patient-Controlled; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009294:Narcotics / Q000008:administration & dosage*; D010098:Oxycodone / Q000008:administration & dosage*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy* / Q000209:etiology; D011446:Prospective Studies; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D009294:Narcotics; D015760:Alfentanil; D010098:Oxycodone