title: [Intravesical instillations in non-muscle-invasive bladder cancer (NMIBC). Prospects for thermochemotherapy].
abstract: Non-muscle-invasive bladder cancer (NMIBC) is characterised by a high risk of recurrence when performing only a transurethral resection of the bladder (TURB). Intravesical instillations are performed postoperatively to decrease the rate of recurrence. The standard agents currently used are Mitomycin-C (MMC) or bacillus Calmette-Guérin (BCG). In order to further enhance the efficacy of the adjuvant treatments and/or diminish their side effects, alternative treatments are studied. Intravesical MMC combined with hyperthermia could be an interesting alternative active treatment for intermediate- and possibly high-risk NMIBC, and has been investigated in the past years. Two methods for achieving hyperthermia are described and presently evaluated: heating the bladder wall by the mean of an intravesical microwave generator (Synergo®) and heating the MMC before it is instilled in the bladder (Combat BRS®).
  
  
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authors.affiliation: Service d'urologie, CHU Bicêtre, 78, rue du Général-Leclerc, 94270 Le-Kremlin-Bicêtre, France. Electronic address: jacquesirani@yahoo.fr.
authors.forename: J
authors.initials: J
authors.lastname: Irani
mesh_terms: D000283:Administration, Intravesical; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D004867:Equipment Design; D006801:Humans; D006979:Hyperthermia, Induced / Q000295:instrumentation; D009130:Muscle, Smooth; D009361:Neoplasm Invasiveness; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents
keywords: Bladder cancer; Chimiothérapie endo-vésicale; Hyperthermia; Hyperthermie; Intravesical chemotherapy; MMC thermochimiothérapie; Mitomycin-C; NMIBC; TVNIM; Thermochemotherapy; Tumeurs de la vessie