title: Water-structuring molecules and nanomaterials enhance radiofrequency heating in biologically relevant solutions.
abstract: For potential applications in nano-mediated radiofrequency cancer hyperthermia, the nanomaterial under investigation must increase the heating of any aqueous solution in which it is suspended when exposed to radiofrequency electric fields. This should also be true for a broad range of solution conductivities, especially those that artificially mimic the ionic environment of biological systems. Herein we demonstrate enhanced heating of biologically relevant aqueous solutions using kosmotropes and a hexamalonoserinolamide fullerene.
authors.affiliation: Department of Chemistry and Smalley-Curl Institute, Rice University, Houston, TX 77005, USA.
authors.forename: Nadia C
authors.initials: NC
authors.lastname: Lara
authors.affiliation: Department of Chemistry and Smalley-Curl Institute, Rice University, Houston, TX 77005, USA.
authors.forename: Asad A
authors.initials: AA
authors.lastname: Haider
authors.affiliation: Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA. scorr@bcm.edu.
authors.forename: Jason C
authors.initials: JC
authors.lastname: Ho
authors.affiliation: Department of Chemistry and Smalley-Curl Institute, Rice University, Houston, TX 77005, USA.
authors.forename: Lon J
authors.initials: LJ
authors.lastname: Wilson
authors.affiliation: Department of Chemistry and Smalley-Curl Institute, Rice University, Houston, TX 77005, USA and Department of Materials Science and Nanoengineering, Rice University, Houston, TX 77005, USA and Energy Safety Research Institute (ESRI), Swansea University Bay Campus, Swansea, SA1 8EN, UK and Centre for NanoHealth (CNH), Swansea University, Singleton Park, Swansea, SA2 8PP, UK.
authors.forename: Andrew R
authors.identifier: http://orcid.org/0000-0002-2018-8288
authors.initials: AR
authors.lastname: Barron
authors.affiliation: Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA. scorr@bcm.edu and Department of Materials Science and Nanoengineering, Rice University, Houston, TX 77005, USA.
authors.forename: Steven A
authors.initials: SA
authors.lastname: Curley
authors.affiliation: Department of Chemistry and Smalley-Curl Institute, Rice University, Houston, TX 77005, USA and Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA. scorr@bcm.edu and Department of Biomedical Engineering, University of Houston, Houston, TX 77204, USA.
authors.forename: Stuart J
authors.initials: SJ
authors.lastname: Corr
mesh_terms: D017115:Catheter Ablation; D037741:Fullerenes / Q000737:chemistry*; D006801:Humans; D006979:Hyperthermia, Induced; D049329:Nanostructures / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D037741:Fullerenes; D014867:Water