title: Familial risk and childhood adversity interplay in the onset of psychosis.
abstract: BACKGROUND
  The association between childhood adversity and psychosis in adulthood is well established. However, genetic factors might confound or moderate this association.
  
  
  OBJECTIVE
  Using a catchment-based case-control sample, we explored the main effects of, and interplay between, childhood adversity and family psychiatric history on the onset of psychosis.
  
  
  METHODS
  Childhood adversity (parental separation and death, physical and sexual abuse) was assessed retrospectively in 224 individuals with a first presentation of psychosis and 256 community controls from South London, UK. Occurrence of psychotic and affective disorders in first-degree relatives was ascertained with the Family Interview for Genetic Studies (FIGS).
  
  
  RESULTS
  Parental history of psychosis did not confound the association between childhood adversity and psychotic disorder. There was no evidence that childhood adversity and familial liability combined synergistically to increase odds of psychosis beyond the effect of each individually.
  
  
  CONCLUSIONS
  Our results do not support the hypothesis that family psychiatric history amplifies the effect of childhood adversity on odds of psychosis.
  
  
  BACKGROUND
  None.
  © The Royal College of Psychiatrists 2015. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) licence.
authors.affiliation: , PhD, , PhD, , PhD, , PhD, , MRCPsych, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
authors.forename: Antonella
authors.initials: A
authors.lastname: Trotta
authors.affiliation: , PhD, , PhD, , PhD, , PhD, , MRCPsych, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
authors.forename: Marta
authors.initials: M
authors.lastname: Di Forti
authors.affiliation: , PhD, , PhD, , PhD, , PhD, , MRCPsych, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
authors.forename: Conrad
authors.initials: C
authors.lastname: Iyegbe
authors.affiliation: , PhD, , PhD, , PhD, , PhD, , MRCPsych, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
authors.forename: Priscilla
authors.initials: P
authors.lastname: Green
authors.affiliation: , PhD, , PhD, , PhD, , PhD, , MRCPsych, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
authors.forename: Paola
authors.initials: P
authors.lastname: Dazzan
authors.affiliation: , PhD, Section of Stress, Psychiatry and Immunology and Perinatal Psychiatry, Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
authors.forename: Valeria
authors.initials: V
authors.lastname: Mondelli
authors.affiliation: , PhD, Health Service and Population Research Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
authors.forename: Craig
authors.initials: C
authors.lastname: Morgan
authors.affiliation: , FRCPsych, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
authors.forename: Robin M
authors.initials: RM
authors.lastname: Murray
authors.affiliation: , PhD, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
authors.forename: Helen L
authors.initials: HL
authors.lastname: Fisher