title: [Fibrous dysplasia: a heterogeneous disease].
abstract: Fibrous dysplasia is a rare genetic bone disorder with a wide variation in clinical expression, ranging from asymptomatic patients to severely affected patients with extensive bone disease, pain, repetitive fractures and deformities and serious endocrinological symptoms (McCune-Albright syndrome). Here, we report on three different cases of fibrous dysplasia. First, a 46-year-old woman with a small solitary lesion in the proximal femur. Second, a 25-year-old man with polyostotic disease of the left leg who received both surgical and medical treatment. Third, a 7-year-old girl with McCune-Albright syndrome who was diagnosed with precocious puberty as a baby and who had extensive disease throughout the skeleton, including multiple lesions in the craniofacial region. The aetiology, clinical expression, diagnostic work-up and therapeutic options for fibrous dysplasia are discussed in a short résumé of the disease.
authors.affiliation: LUMC, Centrum voor Botkwaliteit, Leiden.
authors.forename: B C J
authors.initials: BC
authors.lastname: Majoor
authors.forename: N M
authors.initials: NM
authors.lastname: Appelman-Dijkstra
authors.forename: M A J
authors.initials: MA
authors.lastname: van de Sande
authors.forename: H M
authors.initials: HM
authors.lastname: Kroon
authors.forename: N A T
authors.initials: NA
authors.lastname: Hamdy
authors.forename: P D S
authors.initials: PD
authors.lastname: Dijkstra
mesh_terms: D000328:Adult; D002648:Child; D005260:Female; D005269:Femur; D005357:Fibrous Dysplasia of Bone / Q000175:diagnosis*; D005359:Fibrous Dysplasia, Polyostotic / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D011629:Puberty, Precocious / Q000150:complications