title: Cam Deformity and Acetabular Dysplasia as Risk Factors for Hip Osteoarthritis.
abstract: Cam deformity and acetabular dysplasia have been recognized as relevant risk factors for hip osteoarthritis (OA) in a few prospective studies with limited sample sizes. To date, however, no evidence is available from prospective studies regarding whether the magnitude of these associations differs according to sex, body mass index (BMI), and age.
  
  
  
  Participants in the Rotterdam Study cohort including men and women ages 55 years or older without OA at baseline (n = 4,438) and a mean follow-up of 9.2 years were included in the study. Incident radiographic OA was defined as a Kellgren/Lawrence grade of ≥2 or a total hip replacement at follow-up. Alpha and center-edge angles were measured to determine the presence of cam deformity and acetabular dysplasia/pincer deformity, respectively. Odds ratios (ORs) were calculated to assess the associations between both deformities and the development of OA.
  
  
  
  Subjects with cam deformity (OR 2.11, 95% confidence interval [95% CI] 1.55-2.87) and those with acetabular dysplasia (OR 2.19, 95% CI 1.50-3.21) had a 2-fold increased risk of developing OA compared with subjects without deformity, while pincer deformity did not increase the risk of OA. Stratification analyses showed that the associations of cam deformity and acetabular dysplasia with OA were driven by younger individuals, whereas BMI did not influence the associations. Female sex appears to modify the risk of hip OA related to acetabular dysplasia.
  
  
  
  Individuals with cam deformity and those with acetabular dysplasia are predisposed to OA; these associations were independent of other well-known risk factors. Interestingly, both deformities predisposed to OA only in relatively young individuals. Therefore, early identification of these conditions is important.
authors.affiliation: Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Saberi Hosnijeh
authors.affiliation: Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Maria E
authors.initials: ME
authors.lastname: Zuiderwijk
authors.affiliation: Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Mathijs
authors.initials: M
authors.lastname: Versteeg
authors.affiliation: Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Hieronymus T W
authors.initials: HT
authors.lastname: Smeele
authors.affiliation: Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
authors.affiliation: Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: André G
authors.initials: AG
authors.lastname: Uitterlinden
authors.affiliation: Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Rintje
authors.initials: R
authors.lastname: Agricola
authors.affiliation: Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Edwin H G
authors.initials: EH
authors.lastname: Oei
authors.affiliation: Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Jan H
authors.initials: JH
authors.lastname: Waarsing
authors.affiliation: Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Sita M
authors.initials: SM
authors.lastname: Bierma-Zeinstra
authors.affiliation: Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Joyce B J
authors.initials: JB
authors.lastname: van Meurs
mesh_terms: D000077:Acetabulum / Q000002:abnormalities*; D000368:Aged; D005260:Female; D005270:Femur Head / Q000002:abnormalities*; D005272:Femur Neck / Q000002:abnormalities*; D006801:Humans; D008297:Male; D015207:Osteoarthritis, Hip / Q000453:epidemiology* / Q000209:etiology*; D011446:Prospective Studies; D012307:Risk Factors