title: [T-bet in peripheral T-cell lymphoma].
abstract: Objective:To evaluate the expression of transcription factor T-bet (T-box expressed in T cells) and explore its effects on prognosis in peripheral T-cell lymphoma (PTCL).Methods:This study included 109 previously untreated patients diagnosed with PTCL in the pathology system at Peking Union Medical College Hospital from 2007 to 2013. Formalin-fixed, paraffin-embedded blocks and clinical information of these patients were collected. T-bet expression was examined by immunohistochemical stain, while its relationship with clinical feature and prognosis was analyzed.Results:109 PTCL patients included 60 PTCL-not other specified (PTCL-NOS) cases and 18 NK/T-cell lymphoma. The positive rate of T-bet was 42.2% overall, 43.3% in PTCL-NOS and 44.4% in NK/T lymphoma. T-bet high expression wasn't correlated with OS in PTCL patients (P=0.586) by Kaplan-Meier analysis. Further stratification by pathological subgroup implied a correlation of T-bet high expression with better survival in NK/T lymphoma (P=0.004), but not in PTCL-NOS (P=0.309). Multivariate analysis confirmed that high ECOG score (≥2) was an independent predictor of overall survival (HR=5.907, 95%CI2.399~14.549,P<0.001 ).Conclusion:T-bet was detected in several PTCL subgroups with diversities, which is positively correlated with overall survival in NK/T-cell lymphoma.
authors.affiliation: Department of Hematology, Peking Union Medical College Hospital, Beijing 100730, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: D B
authors.initials: DB
authors.lastname: Zhang
authors.forename: W
authors.initials: W
authors.lastname: Zhou
mesh_terms: D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D016399:Lymphoma, T-Cell; D016411:Lymphoma, T-Cell, Peripheral / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D020825:T-Box Domain Proteins / Q000235:genetics*; D013601:T-Lymphocytes; D000098815:T-bet Transcription Factor
chemical_list: D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor