title: Intratumoral hemorrhage-related differences in the expression of vascular endothelial growth factor, basic fibroblast growth factor and thioredoxin reductase 1 in human glioblastoma.
abstract: The present study was designed to evaluate the expression of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and thioredoxin reductase 1 (TrxR1) in glioblastoma multiforme (GBM) with and without intratumoral hemorrhage. Surgically resected human GBM samples from 20 patients who underwent surgery at our institute were extracted from the histopathological specimens and divided into two groups. A total of 10 samples from each type of GBM (World Health Organization grade IV, intratumoral hemorrhage-positive or -negative) were included in each group. VEGF, bFGF and TrxR1 expression was analyzed using immunohistochemistry and the results were compared between groups. VEGF and bFGF immunoreactivity was significantly higher in GBMs containing intratumoral hemorrhage. Furthermore, VEGF, bFGF and TrxR1 immunointensity was significantly higher in GBMs containing intratumoral hemorrhage. Thus, the present study demonstrated a higher VEGF, bFGF and TrxR1 expression in GBMs contain intratumoral hemorrhage, indicatiogn a role of VEGF, bFGF and TrxR1 expression in the promotion of tumoral angiogenesis and tumoral growth by complex mechanisms that require further elucidation.
authors.affiliation: Department of Neurosurgery, Meram Faculty of Medicine, Necmettin Erbakan University, Meram, Konya 42080, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Kaya
authors.affiliation: Department of Neurosurgery, Ministry of Health, Konya Numune Hospital, Selçuklu, Konya 42060, Turkey.
authors.forename: Onur
authors.initials: O
authors.lastname: Çiçek
authors.affiliation: Department of Neurosurgery, Meram Faculty of Medicine, Necmettin Erbakan University, Meram, Konya 42080, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Erdi
authors.affiliation: Department of Pathology, Meram Faculty of Medicine, Necmettin Erbakan University, Meram, Konya 42080, Turkey.
authors.forename: Siddika
authors.initials: S
authors.lastname: Findik
authors.affiliation: Department of Neurosurgery, Meram Faculty of Medicine, Necmettin Erbakan University, Meram, Konya 42080, Turkey.
authors.forename: Yasar
authors.initials: Y
authors.lastname: Karatas
authors.affiliation: Department of Pathology, Meram Faculty of Medicine, Necmettin Erbakan University, Meram, Konya 42080, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Esen
authors.affiliation: Department of Neurosurgery, Meram Faculty of Medicine, Necmettin Erbakan University, Meram, Konya 42080, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Keskin
authors.affiliation: Department of Neurosurgery, Meram Faculty of Medicine, Necmettin Erbakan University, Meram, Konya 42080, Turkey.
authors.forename: Erdal
authors.initials: E
authors.lastname: Kalkan
keywords: basic fibroblast growth factor; glioblastoma multiforme; hemorrhage; intratumoral; thioredoxin reductase 1; vascular endothelial growth factor