title: Highly enantioselective asymmetric Henry reaction catalyzed by novel chiral phase transfer catalysts derived from cinchona alkaloids.
abstract: A new type of di-site chiral phase transfer catalyst has been designed and synthesized from cinchona alkaloids as a chiral precursor. The prepared catalysts are applied in the asymmetric Henry reaction to a wide range of aldehydes using mild concentrations of a base and solvent and under room-temperature conditions. Under the optimized reaction conditions, the highest chemical yields up to 99% along with an excellent enantiomeric excess (ee) up to 99% were obtained using the prepared cinchona alkaloid based chiral phase transfer catalysts.
authors.affiliation: Department of Inorganic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai-625 021, Tamil Nadu, India. drasiva@gmail.com.
authors.forename: Ponmuthu Kottala
authors.initials: PK
authors.lastname: Vijaya
authors.affiliation: Department of Inorganic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai-625 021, Tamil Nadu, India. drasiva@gmail.com.
authors.forename: Sepperumal
authors.initials: S
authors.lastname: Murugesan
authors.affiliation: Department of Inorganic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai-625 021, Tamil Nadu, India. drasiva@gmail.com.
authors.forename: Ayyanar
authors.initials: A
authors.lastname: Siva
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D002930:Cinchona Alkaloids / Q000737:chemistry*; D009574:Nitro Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D013696:Temperature
chemical_list: D000447:Aldehydes; D002930:Cinchona Alkaloids; D009574:Nitro Compounds