title: Design, synthesis, characterization and antimicrobial/antioxidant activities of 1, 4-dicarbonyl-phenyl-dihydrazide based macrocyclic ligand and its Cu(II), Co(II) and Ni(II) complexes.
abstract: Mononuclear transition metal complexes of Cu(II), Co(II) and Ni(II) with a newly synthesised macrocyclic ligand derived from 1, 4-dicarbonyl-phenyl-dihydrazide and 1,2-diphenylethane-1,2-dione (2:2) have been synthesised. The synthesised compounds were characterised by various physical and spectroscopic techniques including elemental analysis, FTIR, Uv-Vis.,1H NMR, mass spectra, magnetic moment and XRD. The investigation of these macrocyclic complexes established that the stability of metal-ligand coordination through N atoms as tetradentate chelates. The metal/ligands ratio of 1:1 was proposed to afford octahedral geometry for the complexes. The antimicrobial activity of the compounds against some bacterial and fungal species were done by well diffusion method and the results shows that the metal complexes have a promising biological activity comparable with the parent ligand against all bacterial and fungal species. The antioxidant activity of the compounds was also studied through scavenging effect on DPPH radicals with the copper complex showing enhanced activity than other compounds. Additionally, the docking studies predicted the high antimicrobial activity due to the interaction of ligand with the protein.
authors.affiliation: Department of Chemistry, Jamia Millia Islamia, New Delhi, 110025, India.
authors.forename: Parveez
authors.initials: P
authors.lastname: Gull
authors.affiliation: Department of Chemistry, Jamia Millia Islamia, New Delhi, 110025, India.
authors.forename: Ovas Ahmad
authors.initials: OA
authors.lastname: Dar
authors.affiliation: Department of Chemistry, Jamia Millia Islamia, New Delhi, 110025, India.
authors.forename: Manzoor Ahmad
authors.initials: MA
authors.lastname: Malik
authors.affiliation: Department of Chemistry, Jamia Millia Islamia, New Delhi, 110025, India. Electronic address: dr.aahashmi@yahoo.co.in.
authors.forename: Athar Adil
authors.initials: AA
authors.lastname: Hashmi
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000378:metabolism; D005658:Fungi / Q000187:drug effects; D006834:Hydrazines / Q000138:chemical synthesis / Q000494:pharmacology*; D047028:Macrocyclic Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010658:Phenylglyoxal / Q000031:analogs & derivatives; D013057:Spectrum Analysis; D028561:Transition Elements
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D056831:Coordination Complexes; D016166:Free Radical Scavengers; D006834:Hydrazines; D047028:Macrocyclic Compounds; D028561:Transition Elements; D010658:Phenylglyoxal; C006697:benzil
keywords: Antimicrobial activity; Antioxidant activity; Lipophilicity; Macrocyclic ligand