title: Modeling Cancer with Pluripotent Stem Cells.
abstract: The elucidation of cancer pathogenesis has been hindered by limited access to patient samples, tumor heterogeneity and the lack of reliable model organisms. Characterized by their ability to self-renew indefinitely and differentiate into all cell lineages of an organism, pluripotent stem cells (PSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), provide a powerful and unlimited source to generate differentiated cells that can be used to study disease biology, facilitate drug discovery and development, and provide key insights for developing personalized therapies. This article reviews the recent developments and technologies converting PSCs into clinically relevant model systems for cancer research.
authors.affiliation: Women's Health Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
authors.forename: Julian
authors.initials: J
authors.lastname: Gingold
authors.affiliation: Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA.
authors.forename: Ruoji
authors.initials: R
authors.lastname: Zhou
authors.affiliation: Department of Developmental and Regenerative Biology, Department of Pharmacology and System Therapeutics, The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
authors.forename: Ihor R
authors.initials: IR
authors.lastname: Lemischka
authors.affiliation: Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA; Center for Stem Cell and Regenerative Medicine, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
authors.forename: Dung-Fang
authors.initials: DF
authors.lastname: Lee
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms; D009940:Organoids; D039904:Pluripotent Stem Cells
keywords: Cancer Disease Modeling; Differentiation; Genome Editing; Pluripotent Stem Cells