title: Prefrontal cortical activity associated with visual stimulus categorization in non-human primates measured with near-infrared spectroscopy.
abstract: In biomedical research of brain dysfunction in psychiatric disorders, utilization of animal models is essential. However, translation of findings in animal models into the realm of human clinical conditions requires reliable biomarkers that are assessed with the methods mutually employed in animal models and human patients. Near-infrared spectroscopy (NIRS) is a functional neuroimaging technique that has now been widely utilized in human basic and clinical research. However, its application to animal models has been barely conducted. In this study, we developed the method to measure neural activity in the cortex of Japanese macaques using NIRS, and examined cortical responses to presentation of a set of visual stimuli that were categorized into four different groups (flower, monkey, snake, food). Prefrontal cortical (PFC) oxy- and deoxy-hemoglobin changes were found to reliably distinguish the categories of these visual stimuli. The results suggest that cortical activity measurement with NIRS in primates can be a valuable model for identifying biomarkers associated with psychiatric disorders.
authors.affiliation: Department of Food Science and Nutrition, Catholic University of Daegu, Gyeongsan-si, Gyeongbuk, South Korea.
authors.forename: Young-A
authors.initials: YA
authors.lastname: Lee
authors.affiliation: Ecole Nationale Veterinaire de Toulouse, Toulouse, France.
authors.forename: Valentine
authors.initials: V
authors.lastname: Pollet
authors.affiliation: Primate Research Institute, Kyoto University, Inuyama, Aichi, Japan.
authors.forename: Akemi
authors.initials: A
authors.lastname: Kato
authors.affiliation: Primate Research Institute, Kyoto University, Inuyama, Aichi, Japan. Electronic address: goto.yukiori.5c@kyoto-u.ac.jp.
authors.forename: Yukiori
authors.initials: Y
authors.lastname: Goto
mesh_terms: D000818:Animals; D019540:Area Under Curve; D001931:Brain Mapping; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D008251:Macaca; D009483:Neuropsychological Tests; D010775:Photic Stimulation; D017397:Prefrontal Cortex / Q000502:physiology*; D011569:Psychiatric Status Rating Scales; D019265:Spectroscopy, Near-Infrared
chemical_list: D006454:Hemoglobins
keywords: Animal model; Biomarker; Cognitive function; Prefrontal cortex; Psychiatric disorder