title: SOX2 Determines Lineage Restriction: Modeling Lung Squamous Cell Carcinoma in the Mouse.
abstract: In this issue of Cancer Cell, Ferone et al. demonstrate that SOX2 not only drives lung tumor formation but also restricts tumor lineage to squamous cell carcinoma (LSCC), regardless of cell of origin. This novel LSCC model should facilitate identification of key oncogenic drivers and treatment strategies for this lung cancer subtype.
authors.affiliation: Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.
authors.forename: Nicole R
authors.initials: NR
authors.lastname: Murray
authors.affiliation: Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.
authors.forename: Verline
authors.initials: V
authors.lastname: Justilien
authors.affiliation: Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA. Electronic address: fields.alan@mayo.edu.
authors.forename: Alan P
authors.initials: AP
authors.lastname: Fields
mesh_terms: D000818:Animals; D002289:Carcinoma, Non-Small-Cell Lung; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D008175:Lung Neoplasms / Q000235:genetics; D051379:Mice; D009857:Oncogenes; D055748:SOXB1 Transcription Factors / Q000235:genetics*
chemical_list: D055748:SOXB1 Transcription Factors