title: An event map of memory space in the hippocampus.
abstract: The hippocampus has long been implicated in both episodic and spatial memory, however these mnemonic functions have been traditionally investigated in separate research strands. Theoretical accounts and rodent data suggest a common mechanism for spatial and episodic memory in the hippocampus by providing an abstract and flexible representation of the external world. Here, we monitor the de novo formation of such a representation of space and time in humans using fMRI. After learning spatio-temporal trajectories in a large-scale virtual city, subject-specific neural similarity in the hippocampus scaled with the remembered proximity of events in space and time. Crucially, the structure of the entire spatio-temporal network was reflected in neural patterns. Our results provide evidence for a common coding mechanism underlying spatial and temporal aspects of episodic memory in the hippocampus and shed new light on its role in interleaving multiple episodes in a neural event map of memory space.
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands.|Department of Neuropsychology, Institute of Cognitive Neuroscience, Ruhr-University Bochum, Bochum, Germany.
authors.forename: Lorena
authors.identifier: 0000-0002-4939-5862
authors.initials: L
authors.lastname: Deuker
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands.|Kavli Institute for Systems Neuroscience, Centre for Neural Computation, Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, NTNU - Norwegian University of Science and Technology, St. Olavs University Hospital, Trondheim, Norway.
authors.forename: Jacob Ls
authors.identifier: 0000-0002-2098-4487
authors.initials: JL
authors.lastname: Bellmund
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands.|Kavli Institute for Systems Neuroscience, Centre for Neural Computation, Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, NTNU - Norwegian University of Science and Technology, St. Olavs University Hospital, Trondheim, Norway.
authors.forename: Tobias
authors.identifier: 0000-0001-6498-1846
authors.initials: T
authors.lastname: Navarro Schröder
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands.|Kavli Institute for Systems Neuroscience, Centre for Neural Computation, Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, NTNU - Norwegian University of Science and Technology, St. Olavs University Hospital, Trondheim, Norway.
authors.forename: Christian F
authors.initials: CF
authors.lastname: Doeller
mesh_terms: D000328:Adult; D005260:Female; D006624:Hippocampus / Q000033:anatomy & histology / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D061212:Memory, Episodic; D011939:Mental Recall / Q000502:physiology; D010364:Pattern Recognition, Visual / Q000502:physiology; D013028:Space Perception / Q000502:physiology*; D065852:Spatial Memory / Q000502:physiology*; D013647:Task Performance and Analysis; D013998:Time Perception / Q000502:physiology*
keywords: fMRI; hippocampus; human; memory; neuroscience