title: Striking a Balance with Help from our Little Friends - How the Gut Microbiota Contributes to Immune Homeostasis.
abstract: The trillions of microbes that inhabit the human gut (the microbiota) together with the host comprise a complex ecosystem, and like any ecosystem, health relies on stability and balance. Some of the most important members of the human microbiota are those that help maintain this balance via modulation of the host immune system. Gut microbes, through both molecular factors (such as capsular components) and by-products of their metabolism (such as Short Chain Fatty Acids (SCFAs)), can influence both innate and adaptive components of the immune system, in ways that can drive both effector, and regulatory responses. Here we review how commensal microbes can specifically promote a dynamic balance of these immune responses in the mammalian gut.
authors.affiliation: University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
authors.forename: Kathleen L
authors.initials: KL
authors.lastname: Arnolds
authors.affiliation: University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Lozupone
mesh_terms: D000818:Animals; D000069196:Gastrointestinal Microbiome / Q000502:physiology*; D006706:Homeostasis / Q000235:genetics / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000382:microbiology; D016753:Interleukin-10 / Q000378:metabolism; D058504:Th17 Cells / Q000378:metabolism
chemical_list: D016753:Interleukin-10
keywords: IL-10; MAMPS; PSA; SCFA; Th17; iTreg; inflammatory disease; metabolites