title: Influence of Hot Spring Water on Fatty Acid Composition of Skin Surface Lipids in Hairless Mouse Model of Atopic Dermatitis.
abstract: When hairless NCN24 mice with atopic dermatitis (AD) were sprayed with a petroleum-containing alkaline salt spring water rich in metaboric acid and sodium bicarbonate, AD symptoms diminished. Reversed-phase HPLC with fluorescence detection (HPLC/FD) and online MS revealed that fatty acid (FA) composition of the skin surface lipids was similar to that in non-AD mice compared with that in AD mice. Strong negative correlations were noted between the levels of total serum immunoglobulin E (IgE) and palmitoleic acid and between the levels of total serum IgE and branched-hexadecanoic acid. Conversely, a strong positive correlation was noted between the levels of total serum IgE and linoleic acid. The present study demonstrates that the petroleum-containing spring water alters the FA composition of skin surface lipids in AD mice, which can be used as an index to evaluate inflammation.
authors.affiliation: Hokkaido Institute of Public Health.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nishimura
authors.forename: Naoki
authors.initials: N
authors.lastname: Aoyanagi
authors.forename: Eiji
authors.initials: E
authors.lastname: Uchino
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Itabashi
mesh_terms: D000818:Animals; D003876:Dermatitis, Atopic / Q000097:blood / Q000139:chemically induced / Q000378:metabolism*; D004139:Dinitrofluorobenzene; D004195:Disease Models, Animal; D005227:Fatty Acids / Q000378:metabolism*; D045482:Hot Springs; D007073:Immunoglobulin E / Q000097:blood; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D008812:Mice, Hairless; D010578:Petroleum; D012867:Skin / Q000378:metabolism*
chemical_list: D005227:Fatty Acids; D010578:Petroleum; D007073:Immunoglobulin E; D004139:Dinitrofluorobenzene