title: New Strategies for a Comprehensive Fight Against HIV Infection using Monoclonal Antibody Therapy.
abstract: Highly active antiretroviral therapy (ART) has allowed a long-term control of viral replication and HIV infection has been transformed into a chronic disease. However, ART is not able to eradicate the virus, and high levels of inflammation and immune-activation are observed despite prolonged ART. Consequently, a number of comorbidities, such as cardiovascular diseases and cancer, are gaining relevance in patients living with HIV. Moreover, the toxicities associated with continued exposure to ART cause several metabolic disturbances with clinical relevance, and the cost of treatment is a heavy burden for the national health systems. In this scenario, new therapeutic strategies aiming at viral eradication are being actively pursued.
authors.affiliation: Division of Clinical Virology, INIBIC-Complejo Hospitalario Universitario, A Coruña, Spain.
authors.forename: Eva
authors.initials: E
authors.lastname: Poveda
authors.affiliation: Infectious Diseases Unit, Complexo Hospitalario Universitario de Vigo, IIS Galicia Sur, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Crespo
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized; D057134:Antibodies, Neutralizing / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D000080908:Broadly Neutralizing Antibodies; D015483:HIV Antibodies / Q000627:therapeutic use*; D015658:HIV Infections / Q000628:therapy*; D006801:Humans
chemical_list: C000599675:3BNC117 antibody; D019380:Anti-HIV Agents; D061067:Antibodies, Monoclonal, Humanized; D057134:Antibodies, Neutralizing; D000080908:Broadly Neutralizing Antibodies; D015483:HIV Antibodies