title: Secondary generalization of focal-onset seizures: examining the relationship between seizure propagation and epilepsy surgery outcome.
abstract: Surgical intervention often fails to achieve seizure-free results in patients with intractable epilepsy. Identifying features of the epileptic brain that dispose certain patients to unfavorable outcomes is critical for improving surgical candidacy assessments. Recent research by Martinet, Ahmad, Lepage, Cash, and Kramer (J Neurosci35: 9477-9490, 2015) suggests that pathways of secondary seizure generalization distinguish patients with favorable (i.e., seizure free) vs. unfavorable (i.e., seizure persistent) surgical outcomes, lending insights into the network mechanisms of epilepsy surgery failure.
authors.affiliation: School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, New York samuel_tomlinson@urmc.rochester.edu.
authors.forename: Samuel B
authors.initials: SB
authors.lastname: Tomlinson
authors.affiliation: School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, New York.
authors.forename: Arun
authors.initials: A
authors.lastname: Venkataraman
mesh_terms: D004569:Electroencephalography; D004827:Epilepsy / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D019635:Neurosurgical Procedures / Q000379:methods*; D012640:Seizures / Q000601:surgery*; D016896:Treatment Outcome
keywords: epilepsy surgery; epileptogenic zone; network connectivity; secondarily generalized; seizure propagation