title: [Myopathy in a patient during simvastatin and fluconazole treatment].
abstract: A 69-year-old female was admitted due to progressive loss of muscle strength following addition of fluconazole to long-term simvastatin treatment. Rhabdomyolysis was suspected and both drugs were discontinued. Forced diuresis was initiated together with a short course of prednisolone. After 21 weeks the patient had regained normal muscle strength and endurance. The favourable course and the absence of antibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase suggest that the condition was due to interaction between the two drugs, which are both metabolized via the CYP3A4 pathway.
authors.affiliation: jensk@dadlnet.dk.
authors.forename: Jens Kristian
authors.initials: JK
authors.lastname: Pedersen
authors.forename: Magnus Christian
authors.initials: MC
authors.lastname: Lydolph
authors.forename: Finn
authors.initials: F
authors.lastname: Somnier
authors.forename: Peter
authors.initials: P
authors.lastname: Junker
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004347:Drug Interactions; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000628:therapy; D019821:Simvastatin / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000935:Antifungal Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D015725:Fluconazole; D019821:Simvastatin