title: Bifunctional Platinated Nanoparticles for Photoinduced Tumor Ablation.
abstract: Bifunctional self-assembled nanoparticles with a platinated fluorophore core with ultra-low radiative transition are developed, which can generate both singlet oxygen and the photothermal effect for synergistic photodynamic and photothermal therapy with tumor ablation.
authors.affiliation: School of Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, and School of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, China.
authors.forename: Zhengqing
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.
authors.forename: Yelin
authors.initials: Y
authors.lastname: Zou
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.
authors.forename: Hui
authors.initials: H
authors.lastname: He
authors.affiliation: School of Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, and School of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, China.
authors.forename: Jiaming
authors.initials: J
authors.lastname: Rao
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.
authors.forename: Shuangshuang
authors.initials: S
authors.lastname: Ji
authors.affiliation: State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, West Campus, 2 Ling Gong Rd, Dalian, 116024, China.
authors.forename: Xiaoneng
authors.initials: X
authors.lastname: Cui
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.
authors.forename: Hengte
authors.initials: H
authors.lastname: Ke
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.
authors.forename: Yibin
authors.initials: Y
authors.lastname: Deng
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Center of Excellence for Nanosciences, National Center for Nanoscience and Technology of China, Beijing, 100190, China.
authors.forename: Chunying
authors.initials: C
authors.lastname: Chen
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Center of Excellence for Nanosciences, National Center for Nanoscience and Technology of China, Beijing, 100190, China.
authors.forename: Yuliang
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: School of Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, and School of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, China.|Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.
authors.forename: Huabing
authors.initials: H
authors.lastname: Chen
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D006979:Hyperthermia, Induced; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D050997:Nanomedicine / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D010778:Photochemotherapy; D010984:Platinum / Q000737:chemistry*; D026082:Singlet Oxygen / Q000737:chemistry
chemical_list: D026082:Singlet Oxygen; D010984:Platinum
keywords: photodynamic therapy; photosensitizers; photothermal therapy; platinated nanoparticles; tumor ablation