title: Transition-Metal-Catalyzed Asymmetric Hydrogenation and Transfer Hydrogenation: Sustainable Chemistry to Access Bioactive Molecules.
abstract: Over the last few decades, the development of new and highly efficient synthetic methods to obtain chiral compounds has become an increasingly important and challenging research area in modern synthetic organic chemistry. In this account, we review recent work from our laboratory toward the synthesis of valuable chiral building blocks through transition-metal-catalyzed asymmetric hydrogenation and transfer hydrogenation of C=O, C=N and C=C bonds. Application to the synthesis of biologically relevant products is also described.
authors.affiliation: Institut de Recherche de Chimie Paris, PSL Research University, Chimie ParisTech-CNRS, 11 rue Pierre et Marie Curie, 75005, Paris, France.
authors.forename: Tahar
authors.initials: T
authors.lastname: Ayad
authors.affiliation: Institut de Recherche de Chimie Paris, PSL Research University, Chimie ParisTech-CNRS, 11 rue Pierre et Marie Curie, 75005, Paris, France.
authors.forename: Phannarath
authors.initials: P
authors.lastname: Phansavath
authors.affiliation: Institut de Recherche de Chimie Paris, PSL Research University, Chimie ParisTech-CNRS, 11 rue Pierre et Marie Curie, 75005, Paris, France.
authors.forename: Virginie
authors.initials: V
authors.lastname: Ratovelomanana-Vidal
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis*; D002384:Catalysis; D006865:Hydrogenation; D019216:Metals, Heavy / Q000737:chemistry*; D013237:Stereoisomerism; D028561:Transition Elements / Q000737:chemistry*
chemical_list: D001688:Biological Products; D019216:Metals, Heavy; D028561:Transition Elements
keywords: asymmetric catalysis; dynamic kinetic resolution; hydrogenation; total synthesis; transfer hydrogenation