title: Acenocoumarol: A Review of Anticoagulant Efficacy and Safety.
abstract: Anticoagulant treatment is required for the treatment and prevention of thromboembolic disorders. Vitamin K antagonists are commonly used oral anticoagulants worldwide. Acenocoumarol is mono-coumarin derivative with racemic mixture of R (+) and S (-) enantiomers. Efficacy and safety of acenocoumarol has been evaluated in atrial fibrillation, cardiac valve replacement, after myocardial infarction, treatment of deep vein thrombosis, after major surgeries and after critical illness requiring prolonged hospitalization. Acenocoumarol is effective and safe in all age groups. It offers an advantage over warfarin in terms of better stability of anti-coagulant effect. Due to its economic advantage acenocoumarol may be suitable oral anticoagulant for long term use in countries like India.
authors.affiliation: Medical Services Division, Abbott Healthcare Private Limited, Mumbai, Maharashtra.
authors.forename: Abhijit
authors.initials: A
authors.lastname: Trailokya
authors.affiliation: Director, Cath Lab, Ruby Hall Clinic, Pune, Maharashtra.
authors.forename: J S
authors.initials: JS
authors.lastname: Hiremath
authors.affiliation: Sir Ganga Ram Hospital, Delhi.
authors.forename: Jps
authors.initials: J
authors.lastname: Sawhney
authors.affiliation: Director, Department of Cardiovascular Surgery, Fortis Escorts Heart Institute & Research Centre, Delhi.
authors.forename: Y K
authors.initials: YK
authors.lastname: Mishra
authors.affiliation: Consultant Cardiac Surgeon, Chirayu Cardiac Centre, Bhopal.
authors.forename: Vivek
authors.initials: V
authors.lastname: Kanhere
authors.affiliation: Senior Professor of Neurology and Head, Dept. of Neurology, MS Ramaiah Medical college and Hospitals, Bangalore, Karnataka.
authors.forename: R
authors.initials: R
authors.lastname: Srinivasa
authors.affiliation: Consultant Physician, Asian Heart Institute & Research Centre, Karuna Hospital, Mumbai, Maharashtra.
authors.forename: Mangesh
authors.initials: M
authors.lastname: Tiwaskar
mesh_terms: D000074:Acenocoumarol / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D000284:Administration, Oral; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D001281:Atrial Fibrillation / Q000188:drug therapy; D006801:Humans; D007194:India; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors; D009203:Myocardial Infarction / Q000188:drug therapy; D013923:Thromboembolism / Q000517:prevention & control; D016896:Treatment Outcome; D014812:Vitamin K / Q000037:antagonists & inhibitors*
chemical_list: D000925:Anticoagulants; D014812:Vitamin K; D006899:Mixed Function Oxygenases; D000074:Acenocoumarol