title: Co-assembly of polyoxometalates and peptides towards biological applications.
abstract: The synergistic self-assembly of biomolecules with polyoxometalates (POMs) has recently been considered as an effective approach to construct nano-biomaterials with diverse structures and morphologies towards applications in drug delivery, controlled release, tissue engineering scaffolds, and biomineralization, due to the unique features of the clusters in addition to many well-known inorganic nanoparticles. This review presents an overview of recent work focusing on the noncovalent co-assembly of peptides and POMs as well as their biological applications. In the co-assemblies triggered by the interaction between the components significant advantages are observed that POMs or peptides alone do not possess; examples include chiral recognition of hybrid metal oxides, the quick hydrolysis of peptides, and enhanced inhibition of Aβ aggregation. Finally, we outline a brief perspective on possible unresolved issues and future opportunities in this field.
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, Jilin University, No. 2699 Qianjin Street, Changchun 130012, China. yqwu@jlu.edu.cn wulx@jlu.edu.cn.
authors.forename: Pengfan
authors.initials: P
authors.lastname: Gao
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, Jilin University, No. 2699 Qianjin Street, Changchun 130012, China. yqwu@jlu.edu.cn wulx@jlu.edu.cn.
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, Jilin University, No. 2699 Qianjin Street, Changchun 130012, China. yqwu@jlu.edu.cn wulx@jlu.edu.cn.
authors.forename: Lixin
authors.initials: L
authors.lastname: Wu
mesh_terms: D004337:Drug Carriers; D010455:Peptides / Q000737:chemistry*; D023822:Tissue Engineering; D054457:Tissue Scaffolds; D017973:Tungsten Compounds / Q000737:chemistry*; D000099294:Polyoxometalates
chemical_list: D004337:Drug Carriers; D010455:Peptides; D017973:Tungsten Compounds; C102296:polyoxometalate I; D000099294:Polyoxometalates