title: Total ankle arthroplasty versus ankle arthrodesis for the treatment of end-stage ankle arthritis: a meta-analysis of comparative studies.
abstract: Total ankle arthroplasty (TAA) and ankle arthrodesis (AA) are the main surgical treatment options for end-stage ankle arthritis. Although the superiority of each modality remains debated, there remains a lack of high-quality evidence-based studies, such as randomized controlled clinical trials, and meta-analyses of comparative studies. We performed a meta-analysis of comparative studies to determine whether there is a significant difference between these two procedures in terms of (i) clinical scores and patient satisfaction, (ii) re-operations, and (iii) complications.
  
  
  
  We conducted a comprehensive search in the MEDLINE, EMBASE, and Cochrane library databases. Only retrospective or prospective comparative studies were included in this meta-analysis. The literature search, data extraction, and quality assessment were conducted by two independent reviewers. The primary outcomes were clinical scores and patient satisfaction. We also investigated the prevalence of complications and the re-operation rate.
  
  
  
  Ten comparative studies were included (four prospective and six retrospective studies). There were no significant differences between the two procedures in the American Orthopaedic Foot and Ankle Society ankle-hindfoot score, Short Form-36 physical component summary and mental component summary scores, visual analogue scale for pain, and patient satisfaction rate. The risk of re-operation and major surgical complications were significantly increased in the TAA group.
  
  
  
  The meta-analysis revealed that TAA and AA could achieve similar clinical outcomes, whereas the incidence of re-operation and major surgical complication was significantly increased in TAA. Further studies of high methodological quality with long-term follow-up are required to confirm our conclusions.
authors.affiliation: Institute for Evidence-based Medicine, Department of Preventive Medicine, College of Medicine, Korea University, Seoul, South Korea.
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Orthopaedic Surgery, Korea University Ansan Hospital, Ansan-si, South Korea.
authors.forename: Dong Hun
authors.initials: DH
authors.lastname: Suh
authors.affiliation: Department of Orthopaedic Surgery, Veterans Health Service Medical Center, Seoul, South Korea.
authors.forename: Jae Hyuk
authors.initials: JH
authors.lastname: Yang
authors.affiliation: Department of Orthopaedic Surgery, College of Medicine, Yonsei University, Seoul, South Korea.
authors.forename: Jin Woo
authors.initials: JW
authors.lastname: Lee
authors.affiliation: Department of Orthopaedic Surgery, Korea University Guro Hospital, Seoul, South Korea.
authors.forename: Hak Jun
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Institute for Evidence-based Medicine, Department of Preventive Medicine, College of Medicine, Korea University, Seoul, South Korea.
authors.forename: Hyeong Sik
authors.initials: HS
authors.lastname: Ahn
authors.affiliation: Department of Orthopaedic Surgery, Korea University Ansan Hospital, Ansan-si, South Korea.
authors.forename: Seung Woo
authors.initials: SW
authors.lastname: Han
authors.affiliation: Department of Orthopaedic Surgery, Korea University Ansan Hospital, Ansan-si, South Korea. manbalian@gmail.com.
authors.forename: Gi Won
authors.identifier: 0000-0002-7384-8382
authors.initials: GW
authors.lastname: Choi
mesh_terms: D000843:Ankle Joint / Q000601:surgery*; D001168:Arthritis / Q000601:surgery*; D001174:Arthrodesis / Q000379:methods*; D058737:Arthroplasty, Replacement, Ankle / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D010147:Pain Measurement; D017060:Patient Satisfaction; D011446:Prospective Studies; D012086:Reoperation; D012189:Retrospective Studies; D016896:Treatment Outcome; D064232:Visual Analog Scale
keywords: Ankle; Arthritis; Arthrodesis; Arthroplasty; Comparative study; Meta-analysis