title: Do (epi)genetics impact the brain in functional neurologic disorders?
abstract: Advances in neuropsychiatric research are supposed to lead to significant improvements in understanding functional neurologic disorders and their diagnosis. However, epigenetic and genetic research on conversion disorders and somatoform disorders is only at its start. This review demonstrates the current state within this field and tries to bridge a gap from what is known on gene-stress interactions in other psychiatric disorders like depression. The etiology of conversion disorders is hypothesized to be multifactorial. These considerations also suggest that potential etiologic factors lead to alterations in brain function, either episodically or chronically, eventually leading to structural brain changes. In particular, the knowledge of how the environment influences brain structure and function, e.g., via epigenetic regulation, may be interesting for future research in functional neurologic disorders. Reviewing the literature results in evidence that childhood adversities play a role in the development of functional neurologic disorders, whereby at present no reports exist about the interactive effect between childhood adversity and genetic factors or about the impact of epigenetics.
authors.affiliation: Department of Psychiatry and Psychotherapy, Otto von Guericke University of Magdeburg, Germany and Department of Psychiatry, Trinity College, Dublin, Ireland. Electronic address: Thomas.Frodl@med.ovgu.de.
authors.forename: T
authors.initials: T
authors.lastname: Frodl
mesh_terms: D001921:Brain / Q000503:physiopathology*; D044127:Epigenesis, Genetic; D006801:Humans; D009422:Nervous System Diseases / Q000523:psychology*; D013001:Somatoform Disorders / Q000235:genetics*
keywords: conversion disorders; epigenetics; functional neurologic symptom disorder; genetics; gene–environment interactions; psychogenic