title: Body Weight Reduction and Biochemical Parameters of the Patients After RYGB and SG Bariatric Procedures in 12-Month Observation.
abstract: The aim of this study was to evaluate the effect of sleeve gastrectomy (SG) and Roux-en-Y-bypass (RYGB) on anthropometric and biochemical parameters, including changes in glucose levels, lipid profile and liver function. Drastic decrease in all lipid fractions a few weeks or months after the surgery could be regarded as favourable, but low level of HDL is an independent risk factor for heart diseases. Extreme load on the liver without preparation of the patient to the surgery can have negative consequences.
  
  
  
  The test group comprised of 40 female patients at the age of 42.96 with average body weight of 131.56 kg and BMI 46.49. Biochemical analyses were performed using calorimetric method.
  
  
  
  No statistically significant differences were observed in glucose levels between the two types of procedures. The highest differences were noted for triglycerides levels, which decreased, as well as all cholesterol fractions, after RYGB, but were increasing during the first months after SG procedure. Changes in lipid profile, caused by the reduction of all lipid fractions, were more visible after RYGB. The decrease in total cholesterol directly and activity of liver enzymes after the procedure was as higher after RYGB as after SG. Increased activity of transaminases indicates significant liver overload.
  
  
  
  With the selection of groups of patients with similar initial parameters, it is not clear whether the differences between the two procedures when assessing the improvement of glycaemia are significant. However, due to invasive character of RYGB, liver overload lasting several months and lifelong limited absorption of nutrients, the possibility of SG procedure should be considered as a first option.
authors.affiliation: Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Broniewskiego 24, 71-460, Szczecin, Poland. malgorzata.szczuko@pum.edu.pl.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Szczuko
authors.affiliation: Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Broniewskiego 24, 71-460, Szczecin, Poland.
authors.forename: Natalia
authors.initials: N
authors.lastname: Komorniak
authors.affiliation: Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Broniewskiego 24, 71-460, Szczecin, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Hoffmann
authors.affiliation: Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Broniewskiego 24, 71-460, Szczecin, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Walczak
authors.affiliation: Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Broniewskiego 24, 71-460, Szczecin, Poland.
authors.forename: Agata
authors.initials: A
authors.lastname: Jaroszek
authors.affiliation: Department of General and Vascular Surgery, Specialist Hospital named. prof. Alfred Sokołowski, Zdunowo, Poland.
authors.forename: Bartosz
authors.initials: B
authors.lastname: Kowalewski
authors.affiliation: Department of General and Vascular Surgery, Specialist Hospital named. prof. Alfred Sokołowski, Zdunowo, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Kaseja
authors.affiliation: Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Broniewskiego 24, 71-460, Szczecin, Poland.
authors.forename: Dominika
authors.initials: D
authors.lastname: Jamioł-Milc
authors.affiliation: Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Broniewskiego 24, 71-460, Szczecin, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Stachowska
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D005743:Gastrectomy; D015390:Gastric Bypass; D006801:Humans; D008055:Lipids / Q000097:blood; D008111:Liver Function Tests; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood / Q000601:surgery*; D011184:Postoperative Period; D012307:Risk Factors; D015431:Weight Loss
chemical_list: D001786:Blood Glucose; D008055:Lipids
keywords: Bariatric surgery; Dyslipidaemia; Fatty liver; Glucose metabolism; Obesity therapy