title: Neoadjuvant chemotherapy followed by conization to spare fertility in cases of locally advanced cervical cancer: A case report and review of the literature.
abstract: The average age when cervical cancer is diagnosed is decreasing, resulting in a larger proportion of patients seeking fertility preservation. Therefore, a less radical approach that aims to preserve the potential for fertility during the treatment of cervical carcinoma is crucial. The present study reported a case of a patient with stage IB2 cervical cancer who exhibited pathological complete regression to neoadjuvant chemotherapy (NACT). This patient underwent deep cervical conization and laparoscopic lymphadenectomy to preserve her fertility. The patient gave birth at 29 weeks of gestation and exhibited no recurrent disease until May 2016 (72 months after surgery). This is the first, to the best of our knowledge, IB2 case treatment by NACT, followed by conization plus lymphadenectomy, producing favorable oncological and obstetrical outcome. The present study, together with data from a limited number of published articles, offers a new perspective in the preservation of fertility in young women with cervical cancer. Additional studies are required in a selected population.
authors.affiliation: Department of Gynecologic Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510080, P.R. China.
authors.forename: Yanling
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Department of Gynecologic Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510080, P.R. China.
authors.forename: Tiefeng
authors.initials: T
authors.lastname: Cao
authors.affiliation: Department of Gynecologic Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510080, P.R. China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Gynecologic Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510080, P.R. China.
authors.forename: He
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Gynecologic Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510080, P.R. China.
authors.forename: Yujie
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Department of Gynecologic Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510080, P.R. China.
authors.forename: Jihong
authors.initials: J
authors.lastname: Liu
keywords: cervical cancer; conization; fertility sparing; neoadjuvant chemotherapy; pregnancy