title: Validity of LIDAS (LIfetime Depression Assessment Self-report): a self-report online assessment of lifetime major depressive disorder.
abstract: There is a paucity of valid, brief instruments for the assessment of lifetime major depressive disorder (MDD) that can be used in, for example, large-scale genomics, imaging or biomarker studies on depression. We developed the LIfetime Depression Assessment Self-report (LIDAS), which assesses lifetime MDD diagnosis according to DSM criteria, and is largely based on the widely used Composite International Diagnostic Interview (CIDI). Here, we tested the feasibility and determined the sensitivity and specificity for measuring lifetime MDD with this new questionnaire, with a regular CIDI as reference.
  
  
  
  Sensitivity and specificity analyses of the online lifetime MDD questionnaire were performed in adults with (n = 177) and without (n = 87) lifetime MDD according to regular index CIDIs, selected from the Netherlands Study of Depression and Anxiety (NESDA) and Netherlands Twin Register (NTR). Feasibility was tested in an additional non-selective, population-based sample of NTR participants (n = 245).
  
  
  
  Of the 753 invited persons, 509 (68%) completed the LIDAS, of which 419 (82%) did this online. User-friendliness of the instrument was rated high. Median completion time was 6.2 min. Sensitivity and specificity for lifetime MDD were 85% [95% confidence interval (CI) 80-91%] and 80% (95% CI 72-89%), respectively. This LIDAS instrument gave a lifetime MDD prevalence of 20.8% in the population-based sample.
  
  
  
  Measuring lifetime MDD with an online instrument was feasible. Sensitivity and specificity were adequate. The instrument gave a prevalence of lifetime MDD in line with reported population prevalences. LIDAS is a promising tool for rapid determination of lifetime MDD status in large samples, such as needed for genomics studies.
authors.affiliation: Department of Psychiatry and the EMGO Institute for Health and Care Research,VU University Medical Center, and GGZ inGeest,Amsterdam,The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Bot
authors.affiliation: Neuroscience Campus Amsterdam,Amsterdam,The Netherlands.
authors.forename: C M
authors.initials: CM
authors.lastname: Middeldorp
authors.affiliation: Department of Biological Psychology and the EMGO Institute for Health and Care Research,VU University,Amsterdam,The Netherlands.
authors.forename: E J C
authors.initials: EJ
authors.lastname: de Geus
authors.affiliation: Department of Psychiatry and the EMGO Institute for Health and Care Research,VU University Medical Center, and GGZ inGeest,Amsterdam,The Netherlands.
authors.forename: H M
authors.initials: HM
authors.lastname: Lau
authors.affiliation: Department of Biological Psychology and the EMGO Institute for Health and Care Research,VU University,Amsterdam,The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Sinke
authors.affiliation: Department of Biological Psychology and the EMGO Institute for Health and Care Research,VU University,Amsterdam,The Netherlands.
authors.forename: B
authors.initials: B
authors.lastname: van Nieuwenhuizen
authors.affiliation: Department of Psychiatry and the EMGO Institute for Health and Care Research,VU University Medical Center, and GGZ inGeest,Amsterdam,The Netherlands.
authors.forename: J H
authors.initials: JH
authors.lastname: Smit
authors.affiliation: Neuroscience Campus Amsterdam,Amsterdam,The Netherlands.
authors.forename: D I
authors.initials: DI
authors.lastname: Boomsma
authors.affiliation: Department of Psychiatry and the EMGO Institute for Health and Care Research,VU University Medical Center, and GGZ inGeest,Amsterdam,The Netherlands.
authors.forename: B W J H
authors.initials: BW
authors.lastname: Penninx
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000453:epidemiology; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020407:Internet; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D011569:Psychiatric Status Rating Scales / Q000592:standards* / Q000706:statistics & numerical data; D012042:Registries / Q000706:statistics & numerical data*; D015203:Reproducibility of Results; D057566:Self Report / Q000592:standards*; D012680:Sensitivity and Specificity; D055815:Young Adult
keywords: Composite International Diagnostic Interview; lifetime depression; major depressive disorder; online questionnaires