title: Characteristics of and outcomes for elderly patients with acute myocardial infarction: differences between females and males.
abstract: OBJECTIVE
  This study analyzed age-adjusted sex differences among acute myocardial infarction (AMI) patients aged 75 years and above with regard to 7-year mortality (primary end point) and the frequency of angiograms and admission to the coronary care unit (CCU) as well as 1-year mortality (secondary end points).
  
  
  METHODS
  A retrospective cohort study comprised 1,414 AMI patients (748 females and 666 males) aged at least 75 years, who were admitted to Sahlgrenska University Hospital in Gothenburg, Sweden, during two periods (2001/2002 and 2007). All comparisons between female and male patients were age adjusted.
  
  
  RESULTS
  Females were older and their previous history included fewer AMIs, coronary artery bypass grafting procedures, and renal diseases, but more frequent incidence of hypertension. On the contrary, males had higher age-adjusted 7-year mortality in relation to females (hazard ratio [HR] 1.16 with corresponding 95% confidence interval [95% CI 1.03, 1.31],P=0.02). Admission to the CCU was more frequent among males than females (odds ratio [OR] 1.38 [95% CI 1.11, 1.72],P=0.004). There was a nonsignificant trend toward more coronary angiographies performed among males (OR 1.34 [95% CI 1.00, 1.79],P=0.05), as well as a nonsignificant trend toward higher 1-year mortality (HR 1.18 [95% CI 0.99, 1.39],P=0.06).
  
  
  CONCLUSIONS
  In an AMI population aged 75 years and above, males had higher age-adjusted 7-year mortality and higher rate of admission to the CCU than females. One-year mortality did not differ significantly between the sexes, nor did the frequency of performed coronary angiograms.
authors.affiliation: Department of Molecular and Clinical Medicine, Sahlgrenska University Hospital, Gothenburg.
authors.forename: Nguyen Dang
authors.initials: ND
authors.lastname: Thang
authors.affiliation: Department of Molecular and Clinical Medicine, Sahlgrenska University Hospital, Gothenburg; AstraZeneca R&D, Mölndal.
authors.forename: Björn Wilgot
authors.initials: BW
authors.lastname: Karlson
authors.affiliation: Health Metrics, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg.
authors.forename: Thomas
authors.initials: T
authors.lastname: Karlsson
authors.affiliation: Department of Molecular and Clinical Medicine, Sahlgrenska University Hospital, Gothenburg; School of Health Sciences, Research Centre PreHospen, University of Borås, The Pre-hospital Research Centre of Western Sweden, Borås, Sweden.
authors.forename: Johan
authors.initials: J
authors.lastname: Herlitz
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000453:epidemiology; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data; D007674:Kidney Diseases / Q000453:epidemiology; D008297:Male; D009203:Myocardial Infarction / Q000453:epidemiology / Q000401:mortality*; D016017:Odds Ratio; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012737:Sex Factors; D013548:Sweden / Q000453:epidemiology
keywords: acute myocardial infarction; cardiovascular outcomes; characteristics; death; elderly patients