title: Spontaneous neural activity in the right superior temporal gyrus and left middle temporal gyrus is associated with insight level in obsessive-compulsive disorder.
abstract: Insight into illness is an important issue for psychiatry disorder. Although the existence of a poor insight subtype of obsessive-compulsive disorder (OCD) was recognized in the DSM-IV, and the insight level in OCD was specified further in DSM-V, the neural underpinnings of insight in OCD have been rarely explored. The present study was designed to bridge this research gap by using resting-state functional magnetic resonance imaging (fMRI).
  
  
  
  Spontaneous neural activity were examined in 19 OCD patients with good insight (OCD-GI), 18 OCD patients with poor insight (OCD-PI), and 25 healthy controls (HC) by analyzing the amplitude of low-frequency fluctuation (ALFF) in the resting state. Pearson correlation analysis was performed between regional ALFFs and insight levels among OCD patients.
  
  
  
  OCD-GI and OCD-PI demonstrated overlapping and distinct brain alterations. Notably, compared with OCD-GI, tOCD-PI had reduced ALFF in left middle temporal gyrus (MTG) and right superior temporal gyrus (STG), as well as increased ALFF in right middle occipital gyrus. Further analysis revealed that ALFF values for the left MTG and right STG were correlated negatively with insight level in patients with OCD.
  
  
  
  Relatively small sample size and not all patients were un-medicated are our major limitations.
  
  
  
  Spontaneous brain activity in left MTG and right STG may be neural underpinnings of insight in OCD. Our results suggest the great role of human temporal brain regions in understanding insight, and further underscore the importance of considering insight presentation in understanding the clinical heterogeneity of OCD.
authors.affiliation: Medical Psychological center, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China; Medical Psychological institute of Central South University, Changsha, Hunan 410011, PR China.
authors.forename: Jie
authors.initials: J
authors.lastname: Fan
authors.affiliation: Center for Studies of Psychological Application, South China Normal University, Guangzhou 510631, PR China.
authors.forename: Mingtian
authors.initials: M
authors.lastname: Zhong
authors.affiliation: Medical Psychological center, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Gan
authors.affiliation: Medical Psychological center, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China.
authors.forename: Wanting
authors.initials: W
authors.lastname: Liu
authors.affiliation: Medical Psychological center, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China.
authors.forename: Chaoyang
authors.initials: C
authors.lastname: Niu
authors.affiliation: Medical Psychological center, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Liao
authors.affiliation: Medical Psychological center, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China.
authors.forename: Hongchun
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Medical Psychological center, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China.
authors.forename: Changlian
authors.initials: C
authors.lastname: Tan
authors.affiliation: Medical Psychological center, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China. Electronic address: jinyaoyi@gmail.com.
authors.forename: Jinyao
authors.initials: J
authors.lastname: Yi
authors.affiliation: Medical Psychological center, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China; Medical Psychological institute of Central South University, Changsha, Hunan 410011, PR China. Electronic address: xiongzhaozhu@163.com.
authors.forename: Xiongzhao
authors.initials: X
authors.lastname: Zhu
mesh_terms: D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D016022:Case-Control Studies; D032882:Comprehension / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology* / Q000523:psychology*; D013702:Temporal Lobe / Q000503:physiopathology*; D055815:Young Adult
keywords: Amplitudes of low-frequency fluctuation; Insight; Left middle temporal gyrus; Obsessive-compulsive disorder; Right superior temporal gyrus