title: MiR-940 Inhibited Cell Growth and Migration in Triple-Negative Breast Cancer.
abstract: BACKGROUND Breast cancer is the main type of cancer in women, and triple-negative breast cancer (TNBC) is a unique subtype of breast cancer. The expression of miR-940 has been shown to play an important role in various cancers; however, the role of miR-940 in TNBC remains unknown. MATERIAL AND METHODS The expression of miR-940 in TNBC tissues or cells were tested by qRT-PCR; the expression of miR-940 in cells were overexpressed by miR-940 mimics, and suppressed by anti-miR-940. Bioinformatics algorithms from TargetScanHuman were used to predict the target genes of miR-940. The interaction between miR-940 and ZNF24 was confirmed by dual luciferase assays. The protein level was assayed by Western blot. RESULTS TNBC tissues and cells showed lower miR-940 levels. CONCLUSIONS MiR-940 inhibited cellular proliferation and migration in TNBC.
authors.affiliation: Department of Thyroid Breast Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China (mainland).
authors.forename: Lingmi
authors.initials: L
authors.lastname: Hou
authors.affiliation: Department of Breast and Thyroid Surgery, Suining Central Hospital, Suining, Sichuan, China (mainland).
authors.forename: Maoshan
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Breast and Thyroid Surgery, Suining Central Hospital, Suining, Sichuan, China (mainland).
authors.forename: Hongwei
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Thyroid Breast Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China (mainland).
authors.forename: Tianyong
authors.initials: T
authors.lastname: Xing
authors.affiliation: Institute of Hepatobiliarypancreatic-Intestinal Diseases, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China (mainland).
authors.forename: Jingdong
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Radiology, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China (mainland).
authors.forename: Guangwu
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China (mainland).
authors.forename: Lina
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Anatomy, The North Sichuan Medical College, Nanchong, Sichuan, China (mainland).
authors.forename: Shishan
authors.initials: S
authors.lastname: Deng
authors.affiliation: Department of Radiology, Wayne State University, Detroit, MI, USA.
authors.forename: Jiani
authors.initials: J
authors.lastname: Hu
authors.affiliation: Department of Thyroid Breast Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China (mainland).
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing, China (mainland).
authors.forename: Jun
authors.initials: J
authors.lastname: Jiang
mesh_terms: D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D002478:Cells, Cultured; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000235:genetics / Q000378:metabolism; D035683:MicroRNAs / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism; D011379:Prognosis; D064726:Triple Negative Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology
chemical_list: D051741:Kruppel-Like Transcription Factors; C000594732:MIRN940 microRNA, human; D035683:MicroRNAs; C457300:ZNF24 protein, human