title: Biological Subtypes and Distant Relapse Pattern in Breast Cancer Patients After Curative Surgery (Study of Anatolian Society of Medical Oncology).
abstract: OBJECTIVE
  The aim of the study was to investigate the association between the molecular subtypes and patterns of relapse in breast cancer patients who had undergone curative surgery.
  
  
  METHODS
  We retrospectively evaluated 1,350 breast cancer patients with relapses after curative surgery between 1998 and 2012 from referral centers in Turkey. Patients were divided into 4 biological subtypes according to immunohistochemistry and grade: triple negative, HER2 overexpressing, luminal A and luminal B.
  
  
  RESULTS
  The percentages of patients with luminal A, luminal B, HER2-overexpressing, and triple-negative breast cancer were 32.9% (n = 444), 34.9% (n = 471), 12.0% (n = 162), and 20.2% (n = 273), respectively. The distribution of metastases differed among the subgroups: bone (66.2% and 53.9% in luminal A and B vs. 38.9% in HER2-overexpressing and 45.1% in triple negative, p < 0.001), liver (40.1% in HER2-overexpressing vs. 24.5% in luminal A, 33.5% in luminal B, and 27.5% in triple negative, p < 0.001), lung (41.4% in triple negative and 35.2% in HER2-overexpressing vs. 30.2% and 30.6% in luminal A and B, p = 0.008) and brain (25.3% in HER2-overexpressing and 23.1% in triple negative vs. 10.1% and 15.1% in luminal A and B, p < 0.001).
  
  
  CONCLUSIONS
  Organ-specific metastasis may depend on the molecular subtype of breast cancer. Tailored strategies against distant metastasis concerning the molecular subtypes in breast cancer should be considered.
authors.affiliation: Dicle University School of Medicine, Department of Medical Oncology, Diyarbakir, Turkey.
authors.forename: Muhammet A
authors.initials: MA
authors.lastname: Kaplan
authors.affiliation: Ankara Oncology Training and Research Hospital-2, Department of Medical Oncology, Ankara, Turkey.
authors.forename: Ulku Y
authors.initials: UY
authors.lastname: Arslan
authors.affiliation: Dicle University School of Medicine, Department of Medical Oncology, Diyarbakir, Turkey.
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Işıkdogan
authors.affiliation: Marmara University School of Medicine, Department of Medical Oncology, Istanbul, Turkey.
authors.forename: Faysal
authors.initials: F
authors.lastname: Dane
authors.affiliation: Ankara Oncology Training and Research Hospital-2, Department of Medical Oncology, Ankara, Turkey.
authors.forename: Berna
authors.initials: B
authors.lastname: Oksuzoglu
authors.affiliation: Erciyes University School of Medicine, Department of Medical Oncology, Kayseri, Turkey.
authors.forename: Mevlude
authors.initials: M
authors.lastname: Inanc
authors.affiliation: Dokuz Eylul University School of Medicine, Department of Medical Oncology, Izmir, Turkey.
authors.forename: Tulay
authors.initials: T
authors.lastname: Akman
authors.affiliation: Dicle University School of Medicine, Department of Medical Oncology, Diyarbakir, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kucukoner
authors.affiliation: Ankara Oncology Training and Research Hospital-2, Department of Medical Oncology, Ankara, Turkey.
authors.forename: Havva Y
authors.initials: HY
authors.lastname: Cinkir
authors.affiliation: Marmara University School of Medicine, Department of Medical Oncology, Istanbul, Turkey.
authors.forename: Rashad
authors.initials: R
authors.lastname: Rzazade
authors.affiliation: Erciyes University School of Medicine, Department of Medical Oncology, Kayseri, Turkey.
authors.forename: Metin
authors.initials: M
authors.lastname: Ozkan
authors.affiliation: Dokuz Eylul University School of Medicine, Department of Medical Oncology, Izmir, Turkey.
authors.forename: Ugur
authors.initials: U
authors.lastname: Yilmaz
authors.affiliation: I·zmir Ataturk Training and Research Hospital, Department of Medical Oncology, Izmir, Turkey.
authors.forename: Ibrahim V
authors.initials: IV
authors.lastname: Bayoglu
authors.affiliation: Gazi University School of Medicine, Department of Medical Oncology, Ankara, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Gunaydin
authors.affiliation: Sakarya Training and Research Hospital, Department of Medical Oncology, Sakarya, Turkey.
authors.forename: Meltem
authors.initials: M
authors.lastname: Baykara
authors.affiliation: Konya Training and Research Hospital, Department of Medical Oncology, Konya, Turkey.
authors.forename: Dogan
authors.initials: D
authors.lastname: Yazilitas
authors.affiliation: Uludag University School of Medicine, Department of Medical Oncology, Bursa, Turkey.
authors.forename: Erdem
authors.initials: E
authors.lastname: Cubukcu
authors.affiliation: Gaziantep University School of Medicine, Department of Medical Oncology, Gaziantep, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Suner
authors.affiliation: Dıs¸kapı Training and Research Hospital, Department of Medical Oncology, Ankara, Turkey.
authors.forename: Ugur
authors.initials: U
authors.lastname: Ersoy
authors.affiliation: Atatürk University School of Medicine, Department of Medical Oncology, Erzurum, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Bilici
authors.affiliation: Ankara Numune Training and Research Hospital, Department of Medical Oncology, Ankara, Turkey.
authors.forename: Ozan
authors.initials: O
authors.lastname: Yazici
authors.affiliation: Atatürk University School of Medicine, Department of Medical Oncology, Erzurum, Turkey.
authors.forename: Kerim
authors.initials: K
authors.lastname: Cayır
authors.affiliation: Ataturk Training and Research Hospital, Department of Medical Oncology, Ankara, Turkey.
authors.forename: Umut
authors.initials: U
authors.lastname: Demirci
authors.affiliation: Afyon Kocatepe University School of Medicine, Department of Medical Oncology, Afyon, Turkey.
authors.forename: Mukremin
authors.initials: M
authors.lastname: Uysal
keywords: Breast cancer; Molecular subtype; Relapse pattern