title: Correlation of social cognition and neurocognition on psychotic outcome: a naturalistic follow-up study of subjects with attenuated psychosis syndrome.
abstract: Neurocognitive decline has been observed in patients with psychosis as well as attenuated psychosis syndrome (APS). We tested the hypothesis that APS increases dependence on neurocognition during the interpretation of others' mental states and that a combination index of Theory of Mind (ToM) and neurocognition improves the predictive accuracy of psychosis conversion. A sample of 83 APS individuals and 90 healthy controls (HC) were assessed by comprehensive cognitive tests. The cohort also completed a one-year follow-up. In the APS group, ToM was associated with an apparent increase in neurocognition, but this trend was not evident in the HC group. Using the new index of combined neurocognition and ToM scores, the sensitivity for predicting psychosis-proneness was 75% and the specificity was 69%. Our data suggest that the correlations between ToM function and neurocognition in APS subjects were stronger than those in healthy controls. A composite index of neurocognition and ToM could improve the predictive validity of a future conversion to psychosis.
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, P. R. China.
authors.forename: TianHong
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, P. R. China.
authors.forename: HuiRu
authors.initials: H
authors.lastname: Cui
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, P. R. China.
authors.forename: YingYing
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, P. R. China.
authors.forename: LiHua
authors.initials: L
authors.lastname: Xu
authors.affiliation: Florida A &M University, Department of Psychology, Tallahassee, Florida 32307, USA.
authors.forename: HuiJun
authors.initials: H
authors.lastname: Li
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, P. R. China.
authors.forename: YanYan
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, P. R. China.
authors.forename: XiaoHua
authors.initials: X
authors.lastname: Liu
authors.affiliation: Changi General Hospital, Department of Psychological Medicine, Singapore.
authors.forename: Annabelle
authors.initials: A
authors.lastname: Chow
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, P. R. China.
authors.forename: ChunBo
authors.initials: C
authors.lastname: Li
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, P. R. China.
authors.forename: KaiDa
authors.initials: K
authors.lastname: Jiang
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, P. R. China.
authors.forename: ZePing
authors.initials: Z
authors.lastname: Xiao
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, P. R. China.|Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai, China.
authors.forename: JiJun
authors.initials: J
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000523:psychology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000523:psychology*; D012565:Schizophrenic Psychology; D012919:Social Behavior; D056345:Theory of Mind; D055815:Young Adult