title: Hypofractionated accelerated radiotherapy in T1-3 N0 cancer of the larynx: A prospective cohort study with historical controls.
abstract: OBJECTIVE
  The goal of this prospective study was to assess the effectiveness of a hypofractionated accelerated regime in treatment of the larynx cancer.
  
  
  BACKGROUND
  Multiple radiotherapy delivery regimes are used for treatment of the larynx cancer. Hypofractionated regimes could provide similar results with reduced use of radiotherapy facilities.
  
  
  METHODS
  223 patients with squamous cell carcinoma of the upper or middle larynx have been treated with 63 Gy delivered in 28 fractions of 2.25 Gy during 38 days, 5 fractions per week. The study endpoints were overall survival, progression-free survival, early and late treatment toxicity. Standard and accelerated radiotherapy groups from the study published by Hliniak et al.20served as controls.
  
  
  RESULTS
  Five-year actuarial overall survival was 87.5% in the study group, 84.5% in the control group receiving accelerated radiotherapy (33 fractions of 2.0 Gy, 6 fractions per week) and 86.2% in the control group (33 fractions of 2.0 Gy, 5 fractions per week). Five-year progression-free survival was 73.6%, 77.2% and 66.2%, respectively. Overall, treatment toxicity and complication rates did not differ between the study group and the control groups.
  
  
  CONCLUSIONS
  The hypofractionated accelerated radiotherapy protocol using 5 fractions per week reduced the use of radiotherapy facilities. There was no significant difference in overall survival and progression-free survival between the study and control groups treated with accelerated or standard radiotherapy.
authors.affiliation: Head and Neck Cancer Department, Cancer Center - M. Curie-Sklodowska Memorial Institute, ul. Roentgena 5, 02-781 Warsaw, Poland.
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Szutkowski
authors.affiliation: Head and Neck Cancer Department, Cancer Center - M. Curie-Sklodowska Memorial Institute, ul. Roentgena 5, 02-781 Warsaw, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Kawecki
authors.affiliation: Head and Neck Cancer Department, Cancer Center - M. Curie-Sklodowska Memorial Institute, ul. Roentgena 5, 02-781 Warsaw, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Jarząbski
authors.affiliation: Head and Neck Cancer Department, Cancer Center - M. Curie-Sklodowska Memorial Institute, ul. Roentgena 5, 02-781 Warsaw, Poland.
authors.forename: Zofia
authors.initials: Z
authors.lastname: Laskus
authors.affiliation: Head and Neck Cancer Department, Cancer Center - M. Curie-Sklodowska Memorial Institute, ul. Roentgena 5, 02-781 Warsaw, Poland.
authors.forename: Romuald
authors.initials: R
authors.lastname: Krajewski
authors.affiliation: Department of Biostatistics, Cancer Center - M. Curie-Sklodowska Memorial Institute, ul. Roentgena 5, 02-781 Warsaw, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Michalski
authors.affiliation: Medical Physics Department, Cancer Center - M. Curie-Sklodowska Memorial Institute, ul. Roentgena 5, 02-781 Warsaw, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Kukołowicz
keywords: Accelerated radiotherapy; Carcinoma; Hypofractionated radiotherapy; Larynx; Radiotherapy; Squamous cell