title: Organocatalyzed nucleophilic addition of pyrazoles to 2H-azirines: asymmetric synthesis of 3,3-disubstituted aziridines and kinetic resolution of racemic 2H-azirines.
abstract: The first organocatalytic asymmetric nucleophilic addition of arylpyrazoles to 2H-azirines and kinetic resolution of racemic 2H-azirines have been realized. Chiral aziridines were obtained with up to 98% yields and up to 99.9% ee. Meanwhile, simply changing the ratio of reactants, optically active 2H-azirines were recovered in good yields with excellent enantioselectivities.
authors.affiliation: College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China. suoqin@jlu.edu.cn.
authors.forename: Dong
authors.initials: D
authors.lastname: An
authors.affiliation: College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China. suoqin@jlu.edu.cn.
authors.forename: Xukai
authors.initials: X
authors.lastname: Guan
authors.affiliation: College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China. suoqin@jlu.edu.cn.
authors.forename: Rui
authors.initials: R
authors.lastname: Guan
authors.affiliation: College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China. suoqin@jlu.edu.cn.
authors.forename: Lajiao
authors.initials: L
authors.lastname: Jin
authors.affiliation: College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China. suoqin@jlu.edu.cn.
authors.forename: Guangliang
authors.initials: G
authors.lastname: Zhang
authors.affiliation: College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China. suoqin@jlu.edu.cn.
authors.forename: Suoqin
authors.initials: S
authors.lastname: Zhang