title: Iterative Synthesis of Oligo[n]rotaxanes in Excellent Yield.
abstract: We present an operationally simple iterative coupling strategy for the synthesis of oligomeric homo- and hetero[n]rotaxanes with precise control over the position of each macrocycle. The exceptional yield of the AT-CuAAC reaction, combined with optimized conditions that allow the rapid synthesis of the target oligomers, opens the door to the study of precision-engineered oligomeric interlocked molecules.
authors.affiliation: Chemistry, University of Southampton , Highfield, Southampton SO17 1BJ, U.K.
authors.forename: James E M
authors.initials: JE
authors.lastname: Lewis
authors.affiliation: School of Biological Sciences, Queen Mary University of London , London E1 4NS, U.K.
authors.forename: Joby
authors.initials: J
authors.lastname: Winn
authors.affiliation: School of Biological Sciences, Queen Mary University of London , London E1 4NS, U.K.
authors.forename: Luca
authors.initials: L
authors.lastname: Cera
authors.affiliation: Chemistry, University of Southampton , Highfield, Southampton SO17 1BJ, U.K.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Goldup