title: [Gastroprotective effect of honey in Holtzman rats with piroxicam-induced gastric ulcer].
abstract: OBJECTIVE
  To determine the effect of treatment with honey in piroxicam-induced gastric ulcer in Holtzman rats.
  
  
  METHODS
  48 eight-week old female Holtzman rats, weights between 100 and 200 grams, were divided into 6 treatment groups as follow: Group A: water; Group B: piroxicam (30 mg/kg); Group C: omeprazole (5 mg/kg) and piroxicam (30 mg/kg); Group D: honey (2.5 g/kg) and piroxicam (30 mg/kg); Group E: honey (5 g/kg) and piroxicam (30 mg/kg); Group F: honey (7.5 g/kg) and piroxicam (30 mg/kg). Macroscopic studies, using Scion Image, and microscopic histological section of gastric mucosa were performed after the interventions.
  
  
  RESULTS
  The results of the macroscopic studies showed statistically significant differences for both doses of honey at 6 g/kg and 7.5 g/kg when compared to piroxicam (p=0.016 and p=0.001 respectively) and the gastroprotective effect was similar when compared to omeprazole (p>0.05). Microscopic studies showed statistically significant differences only for dose at 7.5 g/kg when compared to piroxicam (p=0.0018) and the gastroprotective effect was similar to omeprazole (p=1).
  
  
  CONCLUSIONS
  Dose of honey at 7.5 g/kg showed gastroprotective effect at microscopic and macroscopic studies when compared to omeprazole.
authors.affiliation: Facultad de Medicina, Universidad Nacional de Trujillo. Trujillo, Perú.
authors.forename: Aníbal Enrique
authors.initials: AE
authors.lastname: Roldán-Rodríguez
authors.affiliation: Facultad de Medicina, Universidad Nacional de Trujillo. Trujillo, Perú.
authors.forename: Erick Joel
authors.initials: EJ
authors.lastname: Vega-Quispe
authors.affiliation: Facultad de Medicina, Universidad Nacional de Trujillo. Trujillo, Perú; Scientia Clinical and Epidemiological Research Institute. Trujillo, Perú.
authors.forename: Isabel
authors.initials: I
authors.lastname: Silva-Ocas
authors.affiliation: Facultad de Medicina, Universidad Nacional de Trujillo. Trujillo, Perú; Círculo de Extensión Socio Cultural Daniel Alcides Carrión. Trujillo, Perú.
authors.forename: Kevin Edward
authors.initials: KE
authors.lastname: Lemus-Arteaga
authors.affiliation: Facultad de Medicina, Universidad Nacional de Trujillo. Trujillo, Perú; Scientia Clinical and Epidemiological Research Institute. Trujillo, Perú.
authors.forename: Jaime Gilberto
authors.initials: JG
authors.lastname: Gonzales-Saldaña
authors.affiliation: Facultad de Medicina, Universidad Nacional de Trujillo. Trujillo, Perú; Sociedad Científica de Estudiantes de Medicina, Universidad Nacional de Trujillo. Trujillo, Perú.
authors.forename: Franklyn Norwich
authors.initials: FN
authors.lastname: Ruiz-Urbina
authors.affiliation: Facultad de Medicina, Universidad Nacional de Trujillo. Trujillo, Perú; Círculo de Extensión Socio Cultural Daniel Alcides Carrión. Trujillo, Perú.
authors.forename: Iván Freddy
authors.initials: IF
authors.lastname: Urtecho-Gaitan
authors.affiliation: Facultad de Medicina, Universidad Nacional de Trujillo. Trujillo, Perú.
authors.forename: Víctor Edwin
authors.initials: VE
authors.lastname: Zamora-Mostacero
authors.affiliation: Facultad de Medicina, Universidad Nacional de Trujillo. Trujillo, Perú; Sociedad Científica de Estudiantes de Medicina, Universidad Nacional de Trujillo. Trujillo, Perú.
authors.forename: Juan Edder
authors.initials: JE
authors.lastname: Vargas-Ferrer
authors.affiliation: Facultad de Medicina, Universidad Nacional de Trujillo. Trujillo, Perú.
authors.forename: Gillmari Juliza
authors.initials: GJ
authors.lastname: Valverde-Quezada
authors.affiliation: Facultad de Medicina, Universidad Nacional de Trujillo. Trujillo, Perú; Sociedad Científica de Estudiantes de Medicina, Universidad Nacional de Trujillo. Trujillo, Perú.
authors.forename: Kevin Oswaldo
authors.initials: KO
authors.lastname: Vásquez-Sandoval
authors.affiliation: Departamento de Ciencias Básicas, Medicina, Universidad Nacional de Trujillo. Trujillo,Perú.
authors.forename: Juan Jorge
authors.initials: JJ
authors.lastname: Huamán-Saavedra
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D005260:Female; D006722:Honey; D009853:Omeprazole / Q000627:therapeutic use; D010894:Piroxicam / Q000009:adverse effects*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D010894:Piroxicam; D009853:Omeprazole