title: In vivo tumor targeting and biodistribution evaluation of paramagnetic solid lipid nanoparticles for magnetic resonance imaging.
abstract: The current study was performed to evaluate the in vivo efficiency of a new nano-sized contrast agent called paramagnetic Solid Lipid Nanoparticles, pSLNs, having promising relaxivity properties for Magnetic Resonance Imaging application. Good stability and stealth properties toward macrophage uptake have been demonstrated. An in vivo MRI study resulted in an improved signal enhancement in the tumor tissue particularly when folate as targeting ligand was used to decorate the nanoparticles surface. Afterward, the biodistribution of pSLNs in several organs was investigated. The accumulation of pSLNs in kidneys, femoral bones, spleen and brain was quite low while high tropism of pSLNs was found for the liver. In this regard, approaches to improve the rate of the hepatic clearance have been proposed.
authors.affiliation: Bracco Imaging SpA, Centro Ricerche Bracco, via Ribes 5, I-10010 Colleretto Giacosa (TO), Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Ghiani
authors.affiliation: Bracco Imaging SpA, Centro Ricerche Bracco, via Ribes 5, I-10010 Colleretto Giacosa (TO), Italy.
authors.forename: Martina
authors.initials: M
authors.lastname: Capozza
authors.affiliation: Bracco Imaging SpA, Centro Ricerche Bracco, via Ribes 5, I-10010 Colleretto Giacosa (TO), Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Cabella
authors.affiliation: Bracco Imaging SpA, Centro Ricerche Bracco, via Ribes 5, I-10010 Colleretto Giacosa (TO), Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Coppo
authors.affiliation: Bracco Imaging SpA, Centro Ricerche Bracco, via Ribes 5, I-10010 Colleretto Giacosa (TO), Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Miragoli
authors.affiliation: Bracco Imaging SpA, Centro Ricerche Bracco, via Ribes 5, I-10010 Colleretto Giacosa (TO), Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Brioschi
authors.affiliation: Bracco Imaging SpA, Centro Ricerche Bracco, via Ribes 5, I-10010 Colleretto Giacosa (TO), Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Bonafè
authors.affiliation: Bracco Imaging SpA, Centro Ricerche Bracco, via Ribes 5, I-10010 Colleretto Giacosa (TO), Italy. Electronic address: alessandro.maiocchi@bracco.com.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Maiocchi
mesh_terms: D045744:Cell Line, Tumor; D006801:Humans; D008055:Lipids; D008279:Magnetic Resonance Imaging; D053758:Nanoparticles; D014018:Tissue Distribution
chemical_list: D008055:Lipids
keywords: Active targeting; Biodistribution; Lipidic nanoparticles; Macrophage uptake; Magnetic resonance imaging