title: High prevalence of dementia in women with osteoporosis.
abstract: BACKGROUND
  Alzheimer's disease or other Dementias (ADD) and postmenopausal osteoporosis are two major public health problems with a huge impact on mortality. Here, we examined the prevalence of ADD in postmenopausal women with osteoporosis, monitored within a dedicated fracture liaison service.
  
  
  METHODS
  We conducted a cross-sectional observational study in a population of 2041 women, visiting the university hospital of Saint-Etienne for a peripheral fragility fracture. We assessed the prevalence of ADD among these patients and compared to French population. We also compared the characteristics of women with ADD and without ADD.
  
  
  RESULTS
  ADD prevalence was on average 13.5% in the population of interest with a mean age of 85years. As women with ADD were older than women without ADD, the prevalence of the disease significantly increased with age as 0%, 1.8%, 13% and 29.7% in<55, 55-74, 75-79 and 85-89years old groups, respectively. Proximal femoral fracture was the most frequent fracture (77%) followed by wrist fracture (13%), and then proximal humerus fracture (10%). ADD prevalence observed in our study was 3 to 4 times the ADD prevalence in France. Despite the overall increase of the ADD prevalence with age, it was still 2.2 and 1.9 times that of the French female population in the 80-84 and 85-89 age groups respectively.
  
  
  CONCLUSIONS
  ADD prevalence was higher in postmenopausal women with severe osteoporosis, especially those with femoral fractures. Thus, our results incite to a more efficient care of this population with a high risk of fracture and mortality.
authors.affiliation: Service de rhumatologie, CHU de Saint-Étienne, 42055 Saint-Étienne cedex 2, France.
authors.forename: Adamah
authors.initials: A
authors.lastname: Amouzougan
authors.affiliation: Service de rhumatologie, CHU de Saint-Étienne, 42055 Saint-Étienne cedex 2, France; INSERM U1059, laboratory biologie intégrée du tissu osseux, université de Lyon, 42023 Saint-Étienne, France.
authors.forename: Ludovic
authors.initials: L
authors.lastname: Lafaie
authors.affiliation: Service de rhumatologie, CHU de Saint-Étienne, 42055 Saint-Étienne cedex 2, France; INSERM U1059, laboratory biologie intégrée du tissu osseux, université de Lyon, 42023 Saint-Étienne, France.
authors.forename: Hubert
authors.initials: H
authors.lastname: Marotte
authors.affiliation: Service de rhumatologie, CHU de Saint-Étienne, 42055 Saint-Étienne cedex 2, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Dẻnariẻ
authors.affiliation: Service de rhumatologie, CHU de Saint-Étienne, 42055 Saint-Étienne cedex 2, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Collet
authors.affiliation: Service de rhumatologie, CHU de Saint-Étienne, 42055 Saint-Étienne cedex 2, France.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Pallot-Prades
authors.affiliation: Service de rhumatologie, CHU de Saint-Étienne, 42055 Saint-Étienne cedex 2, France; INSERM U1059, laboratory biologie intégrée du tissu osseux, université de Lyon, 42023 Saint-Étienne, France. Electronic address: thierry.thomas@chu-st-etienne.fr.
authors.forename: Thierry
authors.initials: T
authors.lastname: Thomas
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D016009:Chi-Square Distribution; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003704:Dementia / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005602:France / Q000453:epidemiology; D006785:Hospitals, University; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000175:diagnosis / Q000453:epidemiology*; D058866:Osteoporotic Fractures / Q000000981:diagnostic imaging / Q000453:epidemiology*; D015995:Prevalence; D011379:Prognosis; D018570:Risk Assessment
keywords: Cognitive functions; Dementia; Fracture; Fracture liaison service; Osteoporosis