title: The orthorhombic pseudopolymorph of tacrine hydrochloride.
abstract: Crystallization of tacrine hydrochloride, an acetylcholinesterase inhibitor used during treatment of mild to moderate Alzheimer's disease, from a water:ethanol solution has resulted in an orthorhombic pseudopolymorph. This orthorhombic form which occurs as a dihydrate shows columns of stacking acridines together with continuous Cl-Owater-Owater-Cl chains and ladder-like ribbons composed of squares and hexagons.
authors.affiliation: Chemistry Department, KU Leuven, Celestijnenlaan 200F Box 2404, Leuven (Heverlee), B-3001, Belgium.
authors.forename: Jeroen
authors.initials: J
authors.lastname: Jacobs
authors.affiliation: Chemistry Department, KU Leuven, Celestijnenlaan 200F Box 2404, Leuven (Heverlee), B-3001, Belgium.
authors.forename: Michele
authors.initials: M
authors.lastname: Moris
authors.affiliation: Chemistry Department, KU Leuven, Celestijnenlaan 200F Box 2404, Leuven (Heverlee), B-3001, Belgium.
authors.forename: Tim
authors.initials: T
authors.lastname: De Samber
authors.affiliation: Chemistry Department, KU Leuven, Celestijnenlaan 200F Box 2404, Leuven (Heverlee), B-3001, Belgium.
authors.forename: Johannes
authors.initials: J
authors.lastname: Vrijdag
authors.affiliation: Chemistry Department, KU Leuven, Celestijnenlaan 200F Box 2404, Leuven (Heverlee), B-3001, Belgium.
authors.forename: Wim
authors.initials: W
authors.lastname: De Borggraeve
authors.affiliation: Chemistry Department, KU Leuven, Celestijnenlaan 200F Box 2404, Leuven (Heverlee), B-3001, Belgium.
authors.forename: Luc
authors.initials: L
authors.lastname: Van Meervelt
mesh_terms: D002800:Cholinesterase Inhibitors / Q000737:chemistry; D003460:Crystallization; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D008958:Models, Molecular; D015394:Molecular Structure; D013619:Tacrine / Q000737:chemistry*
chemical_list: D002800:Cholinesterase Inhibitors; D013619:Tacrine
keywords: acetylcholinesterase (AChE) inhibitor; dihydrate; pseudopolymorphism; tacrine hydrochloride