title: Advances in Drug Discovery: Impact of Genomics and Role of Analytical Instrumentation.
abstract: Drug discovery is a highly complicated, tedious and potentially rewarding approach associated with great risk. Pharmaceutical companies literally spend millions of dollars to produce a single successful drug. The drug discovery process also need strict compliance to the directions on manufacturing and testing of new drug standards before their release into market. All these regulations created the necessity to develop advanced approaches in drug discovery. The contributions of advanced technologies including high resolution analytical instruments, 3-D biological printing, next-generation sequencing and bioinformatics have made positive impact on drug discovery & development. Fortunately, all these advanced technologies are evolving at the right time when new issues are rising in drug development process. In the present review, we have discussed the role of genomics and advanced analytical techniques in drug discovery. Further, we have also discussed the significant advances in drug discovery as case studies.
authors.forename: Ambavaram
authors.initials: A
authors.lastname: Vijaya Bhaskar Reddy
authors.forename: Zulkifli
authors.initials: Z
authors.lastname: Yusop
authors.affiliation: Department of Chemistry, Universiti Teknologi Malaysia, Johor 81300, Malaysia. jafariah@kimia.fs.utm.my.
authors.forename: Jafariah
authors.initials: J
authors.lastname: Jaafar
authors.forename: Vemula
authors.initials: V
authors.lastname: Madhavi
authors.forename: Gajulapalle
authors.initials: G
authors.lastname: Madhavi
mesh_terms: D000818:Animals; D002623:Chemistry Techniques, Analytical / Q000295:instrumentation*; D055808:Drug Discovery; D015894:Genome, Human; D023281:Genomics; D006801:Humans; D055818:Public-Private Sector Partnerships