title: Dihydroquercetin Does Not Affect Age-Dependent Increase in Blood Pressure and Angiotensin-Converting Enzyme Activity in the Aorta of Hypertensive Rats.
abstract: We analyzed changes in angiotensin-converting enzyme activity in the aorta of hypertensive SHR rats against the background of age-related BP increase (from week 7 to 14) and the effect of dihydroquercetin on BP rise and angiotensin-converting enzyme activity. Normotensive WKY rats of the same age were used as the control. BP and activity of angiotensin-converting enzyme in the aorta of SHR rats increased with age. Dihydroquercetin in doses of 100 and 300 μg/kg per day had no effect on the increase of these parameters; dihydroquercetin administered to 14-week-old WKY rats in a dose of 300 μg/kg reduced activity of the angiotensin-converting enzyme. Thus, the early (7-14 weeks) increase in BP and angiotensin-converting enzyme activity in the aorta of SHR rats was not modified by flavonoids (dihydroquercetin) in contrast to other rat strains and humans, which is indicative of specificity of hypertension mechanism in SHR rats.
authors.affiliation: Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Russia.
authors.forename: G A
authors.initials: GA
authors.lastname: Slashcheva
authors.affiliation: Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Rykov
authors.affiliation: Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Lobanov
authors.affiliation: Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Russia.
authors.forename: A N
authors.initials: AN
authors.lastname: Murashev
authors.affiliation: Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Russia.
authors.forename: Yu A
authors.initials: YA
authors.lastname: Kim
authors.affiliation: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.
authors.forename: T V
authors.initials: TV
authors.lastname: Arutyunyan
authors.affiliation: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.
authors.forename: A F
authors.initials: AF
authors.lastname: Korystova
authors.affiliation: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.
authors.forename: L N
authors.initials: LN
authors.lastname: Kublik
authors.affiliation: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.
authors.forename: M Kh
authors.initials: MK
authors.lastname: Levitman
authors.affiliation: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Shaposhnikona
authors.affiliation: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia. ykorystov@rambler.ru.
authors.forename: Yu N
authors.initials: YN
authors.lastname: Korystov
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001011:Aorta / Q000187:drug effects / Q000201:enzymology*; D001794:Blood Pressure; D004353:Drug Evaluation, Preclinical; D006339:Heart Rate; D006973:Hypertension / Q000188:drug therapy / Q000201:enzymology* / Q000503:physiopathology; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D011794:Quercetin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
chemical_list: D000959:Antihypertensive Agents; D011794:Quercetin; C003377:taxifolin; D007703:Peptidyl-Dipeptidase A
keywords: SHR; angiotensin-converting enzyme; aorta; dihydroquercetin; hypertension