title: The association between pre-operative variables, including blood pressure, and postoperative kidney function.
abstract: We used multivariate analyses to assess the association of pre-operative variables with kidney function in 41,523 adults after scheduled surgery in a single large academic hospital. Eight variables were independently associated with a reduction in postoperative estimated glomerular filtration rate: pre-operative renal function; age; ASA physical status; cardiac failure; anaemia; cancer; type of surgery; and the lowest quartile of pre-operative mean arterial blood pressure (< 71 mmHg). The estimated glomerular filtration rate fell by a mean (95% CI) of 2.7 (0.04-5.40) ml.min-1.1.73 m-2for patients with a pre-operative mean arterial pressure < 71 mmHg, p = 0.047. The same variables and male sex were associated with postoperative acute kidney injury. The odds ratio (95% CI) for acute postoperative kidney injury was 1.9 (1.2-2.9) for patients with a pre-operative mean arterial blood pressure < 71 mmHg, p = 0.005.
authors.affiliation: Department of Anesthesiology, Peri-operative Care and Pain Medicine, New York University Langone Medical Center, New York, New York, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Kendale
authors.affiliation: Department of Anesthesiology, Peri-operative Care and Pain Medicine, New York University Langone Medical Center, New York, New York, USA.
authors.forename: P N
authors.initials: PN
authors.lastname: Lapis
authors.affiliation: Department of Anesthesiology, Peri-operative Care and Pain Medicine, New York University Langone Medical Center, New York, New York, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Melhem
authors.affiliation: Department of Anesthesiology, Peri-operative Care and Pain Medicine, New York University Langone Medical Center, New York, New York, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Blitz
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology; D000328:Adult; D000368:Aged; D001794:Blood Pressure; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011184:Postoperative Period; D011300:Preoperative Care
keywords: logistic regression: odds ratio; peri-operative antihypertensive drug management; peri-operative renal failure: predictor