title: Theranostic Bioabsorbable Bone Fixation Plate with Drug-Layered Double Hydroxide Nanohybrids.
abstract: A bioabsorbable polymeric bone plate enabled with both diagnostic and therapeutic functionalities (radiopacity and sustained drug release, respectively) is proposed. To this end, a drug-inorganic nanohybrid (RS-LDH) is examined as a theranostic agent by intercalating an anti-resorptive bone remodeling drug, risedronate (RS) into a layered double hydroxide (LDH) via an ion-exchange reaction. The RS-LDH is prepared as a sheet with a biodegradable polymer, poly(lactic-co-glycolic acid), and is then attached onto the clinically approved bioabsorbable bone plate to produce the theranostic plate. Because of the presence of the metals in the LDH, the theranostic plate results in discernible in vivo X-ray images for up to four weeks after implantation. Concurrently, bone regeneration is also significantly improved compared with the other control groups, likely because of this material's sustained drug-release property. The theranostic plate is also largely biocompatible, similar to the plate already approved for clinical use. It is concluded that the combination of a biodegradable bone plate with RS-LDH nanohybrids can constitute a promising system with theranostic ability in both X-ray diagnosis and expedited bone repair.
authors.affiliation: Center for Intelligent Nano-Bio Materials (CINBM), Department of Chemistry and Nano Science, Ewha Womans University, Seoul, 03760, Republic of Korea.|Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul, 08826, Republic of Korea.
authors.forename: Myung Hun
authors.initials: MH
authors.lastname: Kim
authors.affiliation: Biomedical Research Institute, Seoul National University Hospital, Seoul, 03080, Republic of Korea.|Department of Plastic and Reconstructive Surgery, Institute of Human-Environment Interface Biology, College of Medicine, Seoul National University, Seoul, 03080, Republic of Korea.
authors.forename: Woojune
authors.initials: W
authors.lastname: Hur
authors.affiliation: Center for Intelligent Nano-Bio Materials (CINBM), Department of Chemistry and Nano Science, Ewha Womans University, Seoul, 03760, Republic of Korea.
authors.forename: Goeun
authors.initials: G
authors.lastname: Choi
authors.affiliation: Department of Preventive Medicine, Graduate School of Public Health, Seoul National University, Seoul, 08826, Korea.
authors.forename: Hye Sook
authors.initials: HS
authors.lastname: Min
authors.affiliation: Biomedical Research Institute, Seoul National University Hospital, Seoul, 03080, Republic of Korea.|Department of Plastic and Reconstructive Surgery, Institute of Human-Environment Interface Biology, College of Medicine, Seoul National University, Seoul, 03080, Republic of Korea.
authors.forename: Tae Hyun
authors.initials: TH
authors.lastname: Choi
authors.affiliation: Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul, 08826, Republic of Korea.|Institute of Medical and Biological Engineering, Medical Research Center and Department of Biomedical Engineering, College of Medicine, Seoul National University, Seoul, 03080, Republic of Korea.
authors.forename: Young Bin
authors.initials: YB
authors.lastname: Choy
authors.affiliation: Center for Intelligent Nano-Bio Materials (CINBM), Department of Chemistry and Nano Science, Ewha Womans University, Seoul, 03760, Republic of Korea.
authors.forename: Jin-Ho
authors.initials: JH
authors.lastname: Choy
mesh_terms: D020341:Absorbable Implants; D001860:Bone Plates; D001861:Bone Regeneration / Q000187:drug effects*; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000737:chemistry*; D006878:Hydroxides / Q000008:administration & dosage* / Q000737:chemistry*; D019344:Lactic Acid / Q000737:chemistry; D008422:Materials Testing / Q000379:methods; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000008:administration & dosage / Q000737:chemistry; D000068936:Theranostic Nanomedicine / Q000379:methods; D014965:X-Rays
chemical_list: D003692:Delayed-Action Preparations; D006878:Hydroxides; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C031356:hydroxide ion
keywords: X-ray visibility; bioabsorbable bone fixation plates; bone regeneration; layered double hydroxide; risedronate