title: Age and HPV type as risk factors for HPV persistence after loop excision in patients with high grade cervical lesions: an observational study.
abstract: BACKGROUND
  Persistent infections with high risk human papillomaviruses (HR-HPV) cause virtually all cervical cancers.
  
  
  METHODS
  An observational study was conducted aiming to estimate the rate of HPV infection persistence after LEEP in patients with high grade squamous intraepithelial lesions (HSIL). Moreover, the study investigated if persistence is age related. For this reason a total of 110 patients were included between January 2010 and June 2015.
  
  
  RESULTS
  At 6 months after LEEP the overall HPV infection persistence rate was 40.9 %, at 12 months 20 % and at 18 months 11.8 %. Type 16 showed the highest persistence rate: 27.3 % at 6 months, 12.7 % at 12 months and 10 % at 18 months after LEEP. The persistence for HPV type 16 at 6 months after LEEP was significantly higher in the group > =36.5 years old compared to the persistence rate in the group <36.5 years old (p = 0.0027, RR = 2.75, 95 %ϵ(1.34; 5.64)) (see Table 3).
  
  
  CONCLUSIONS
  LEEP does not completely eradicate HPV infection. HPV persistence rate after LEEP is higher in infections with type 16 and in women older than 36.5 years.
authors.affiliation: Department of Obstetrics and Gynecology, University of Medicine and Pharmacy "Victor Babeş", Timişoara, Romania.|County Hospital Timișoara, Hector street, number 1, Timișoara, Romania.
authors.forename: Laurențiu
authors.initials: L
authors.lastname: Pirtea
authors.affiliation: Department of Obstetrics and Gynecology, University of Medicine and Pharmacy "Victor Babeş", Timişoara, Romania.|County Hospital Timișoara, Hector street, number 1, Timișoara, Romania.
authors.forename: Dorin
authors.initials: D
authors.lastname: Grigoraş
authors.affiliation: Department of Anatomy, University of Medicine and Pharmacy "Victor Babeş", Timişoara, Romania.|County Hospital Timișoara, Hector street, number 1, Timișoara, Romania.
authors.forename: Petru
authors.initials: P
authors.lastname: Matusz
authors.affiliation: Department of Obstetrics and Gynecology, County Hospital Timişoara, Timișoara, Romania.|County Hospital Timișoara, Hector street, number 1, Timișoara, Romania.
authors.forename: Marilena
authors.initials: M
authors.lastname: Pirtea
authors.affiliation: Department of Informatics and Biostatistics, University of Medicine and Pharmacy "Victor Babeş", Timişoara, Romania.|County Hospital Timișoara, Hector street, number 1, Timișoara, Romania.
authors.forename: Lavinia
authors.initials: L
authors.lastname: Moleriu
authors.affiliation: Department of Informatics and Biostatistics, University of Medicine and Pharmacy "Victor Babeş", Timişoara, Romania.|County Hospital Timișoara, Hector street, number 1, Timișoara, Romania.
authors.forename: Anca
authors.initials: A
authors.lastname: Tudor
authors.affiliation: Department of Surgery, University of Medicine and Pharmacy "Victor Babeş", str. Dimitrie Cantemir, nr. 1, Zip Code 300001, Timişoara, Romania. razvanilina@yahoo.co.uk.|County Hospital Timișoara, Hector street, number 1, Timișoara, Romania. razvanilina@yahoo.co.uk.
authors.forename: Răzvan
authors.initials: R
authors.lastname: Ilina
authors.affiliation: Department of Obstetrics and Gynecology, County Hospital Timişoara, Timișoara, Romania.|County Hospital Timișoara, Hector street, number 1, Timișoara, Romania.
authors.forename: Cristina
authors.initials: C
authors.lastname: Secoşan
authors.affiliation: Department of Microbiology, University of Medicine and Pharmacy "Victor Babeş", Timişoara, Romania.|County Hospital Timișoara, Hector street, number 1, Timișoara, Romania.
authors.forename: Florin
authors.initials: F
authors.lastname: Horhat
authors.affiliation: Department of Surgery, University of Medicine and Pharmacy "Victor Babeş", str. Dimitrie Cantemir, nr. 1, Zip Code 300001, Timişoara, Romania.|County Hospital Timișoara, Hector street, number 1, Timișoara, Romania.
authors.forename: Octavian
authors.initials: O
authors.lastname: Mazilu
mesh_terms: D000328:Adult; D000367:Age Factors; D002584:Cervix Uteri / Q000601:surgery*; D003127:Colposcopy; D004279:DNA, Viral / Q000032:analysis; D004598:Electrosurgery / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D013509:Gynecologic Surgical Procedures / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics*; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D011184:Postoperative Period; D012189:Retrospective Studies; D012307:Risk Factors; D012383:Romania / Q000453:epidemiology; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000150:complications / Q000175:diagnosis / Q000601:surgery*
chemical_list: D004279:DNA, Viral
keywords: Age; HPV type 16; Infection persistence; LEEP