title: High-performance liquid chromatography coupled with tandem mass spectrometry technology in the analysis of Chinese Medicine Formulas: A bibliometric analysis (1997-2015).
abstract: There is a recognized challenge in analyzing traditional Chinese medicine formulas because of their complex chemical compositions. The application of modern analytical techniques such as high-performance liquid chromatography coupled with a tandem mass spectrometry has improved the characterization of various compounds from traditional Chinese medicine formulas significantly. This study aims to conduct a bibliometric analysis to recognize the overall trend of high-performance liquid chromatography coupled with tandem mass spectrometry approaches in the analysis of traditional Chinese medicine formulas, its significance and possible underlying interactions between individual herbs in these formulas. Electronic databases were searched systematically, and the identified studies were collected and analyzed using Microsoft Access 2010, Graph Pad 5.0 software and Ucinet software package. 338 publications between 1997 and 2015 were identified, and analyzed in terms of annual growth and accumulated publications, top journals, forms of traditional Chinese medicine preparations and highly studied formulas and single herbs, as well as social network analysis of single herbs. There is a significant increase trend in using high-performance liquid chromatography coupled with tandem mass spectrometry related techniques in analysis of commonly used forms of traditional Chinese medicine formulas in the last 3 years. Stringent quality control is of great significance for the modernization and globalization of traditional Chinese medicine, and this bibliometric analysis provided the first and comprehensive summary within this field.
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Integration of Traditional Chinese and Western Medicine, Peking University School of Oncology, Peking University Cancer Hospital & Institute, Beijing, China.
authors.forename: Xi-Ran
authors.initials: XR
authors.lastname: He
authors.affiliation: National Institute of Complementary Medicine, Western Sydney University, Campbelltown, NSW, Australia.
authors.forename: Chun-Guang
authors.initials: CG
authors.lastname: Li
authors.affiliation: National Institute of Complementary Medicine, Western Sydney University, Campbelltown, NSW, Australia.
authors.forename: Xiao-Shu
authors.initials: XS
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Integration of Traditional Chinese and Western Medicine, Peking University School of Oncology, Peking University Cancer Hospital & Institute, Beijing, China.
authors.forename: Yuan-Qing
authors.initials: YQ
authors.lastname: Li
authors.affiliation: National Institute of Complementary Medicine, Western Sydney University, Campbelltown, NSW, Australia.
authors.forename: Mariam
authors.initials: M
authors.lastname: Jarouche
authors.affiliation: National Institute of Complementary Medicine, Western Sydney University, Campbelltown, NSW, Australia.
authors.forename: Alan
authors.initials: A
authors.lastname: Bensoussan
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Integration of Traditional Chinese and Western Medicine, Peking University School of Oncology, Peking University Cancer Hospital & Institute, Beijing, China.
authors.forename: Ping-Ping
authors.initials: PP
authors.lastname: Li
mesh_terms: D015706:Bibliometrics; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000032:analysis*; D013058:Mass Spectrometry; D008516:Medicine, Chinese Traditional / Q000639:trends; D053719:Tandem Mass Spectrometry
chemical_list: D004365:Drugs, Chinese Herbal
keywords: Bibliometrics; High-performance liquid chromatography; Mass spectrometry; Traditional Chinese Medicine