title: Hyeonggaeyeongyo-Tang for Treatment of Allergic and Nonallergic Rhinitis: A Prospective, Nonrandomized, Pre-Post Study.
abstract: Hyeonggaeyeongyo-tang (HYT) is an ancient formula of oriental medicine traditionally used to treat rhinitis; however, clinical evidence has not yet been established. The aim of this study was to investigate the short-term and long-term efficacy and safety of HYT for chronic rhinitis. Adult subjects with chronic rhinitis symptoms were recruited. The subjects received HYT for 4 weeks and had follow-up period of 8 weeks. Any medicines used to treat nasal symptoms were not permitted during the study. The skin prick test was performed to distinguish the subjects with allergic rhinitis from those with nonallergic rhinitis. After treatment, the total nasal symptoms score and the Rhinoconjunctivitis Quality of Life Questionnaire score significantly improved in the whole subject group, in the allergic rhinitis group, and in the nonallergic rhinitis group, with no adverse events. This improvement lasted during a follow-up period of 8 weeks. Total IgE and eosinophil levels showed no significant difference after treatment in the allergic rhinitis group. HYT improved nasal symptoms and quality of life in patients with allergic rhinitis and nonallergic rhinitis. This is the first clinical study to evaluate the use of HYT to treat patients with rhinitis. This trial has been registered with the ClinicalTrials.gov Identifier NCT02477293.
authors.affiliation: Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea; Department of Otorhinolaryngology of Korean Medicine, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea.
authors.forename: Min-Hee
authors.identifier: 0000-0002-6593-2410
authors.initials: MH
authors.lastname: Kim
authors.affiliation: Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea; Department of Otorhinolaryngology of Korean Medicine, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea.
authors.forename: Jaewoong
authors.identifier: 0000-0002-0133-9458
authors.initials: J
authors.lastname: Son
authors.affiliation: Department of Ophthalmology & Otorhinolaryngology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Hae Jeong
authors.identifier: 0000-0002-9974-0863
authors.initials: HJ
authors.lastname: Nam
authors.affiliation: Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Seong-Gyu
authors.identifier: 0000-0002-2345-430X
authors.initials: SG
authors.lastname: Ko
authors.affiliation: Department of Otorhinolaryngology of Korean Medicine, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea; Department of Ophthalmology & Otorhinolaryngology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Inhwa
authors.identifier: 0000-0001-7416-2772
authors.initials: I
authors.lastname: Choi