title: Steroid glycosides from the starfish Pentaceraster gracilis.
abstract: Using combined chromatographic separations, two new steroid glycosides namely pentacerosides A (1) and B (2), and four known compounds were isolated from the methanol extract of the starfish Pentaceraster gracilis. Their structures were determined on the basis of spectroscopic data (1H and13C NMR, HSQC, HMBC,1H-1H COSY, ROESY, and FT-ICR-MS) and by comparing obtained results to the literature values. Among the isolated compounds, only maculatoside (5) showed significant cytotoxic effect against Hep-G2 (IC50= 16.75 ± 0.69 μM) and SK-Mel2 (IC50= 19.44 ± 1.45 μM) cell lines and moderate effect on KB (IC50= 36.53 ± 0.78 μM), LNCaP (IC50= 39.75 ± 3.34 μM), and MCF7 (IC50= 47.34 ± 7.01 μM) cell lines.
authors.affiliation: a Institute of Marine Biochemistry (IMBC) , Vietnam Academy of Science and Technology (VAST) , Hanoi , Vietnam.
authors.forename: Le Thi
authors.initials: LT
authors.lastname: Vien
authors.affiliation: a Institute of Marine Biochemistry (IMBC) , Vietnam Academy of Science and Technology (VAST) , Hanoi , Vietnam.
authors.forename: Bui Thi
authors.initials: BT
authors.lastname: Ngoan
authors.affiliation: a Institute of Marine Biochemistry (IMBC) , Vietnam Academy of Science and Technology (VAST) , Hanoi , Vietnam.
authors.forename: Tran Thi Hong
authors.initials: TT
authors.lastname: Hanh
authors.affiliation: a Institute of Marine Biochemistry (IMBC) , Vietnam Academy of Science and Technology (VAST) , Hanoi , Vietnam.
authors.forename: Le Ba
authors.initials: LB
authors.lastname: Vinh
authors.affiliation: b Institute of Marine Environment and Resources (IMER), VAST , Haiphong , Vietnam.
authors.forename: Do Cong
authors.initials: DC
authors.lastname: Thung
authors.affiliation: c Institute of Biotechnology (IBT), VAST , Hanoi , Vietnam.
authors.forename: Do Thi
authors.initials: DT
authors.lastname: Thao
authors.affiliation: a Institute of Marine Biochemistry (IMBC) , Vietnam Academy of Science and Technology (VAST) , Hanoi , Vietnam.
authors.forename: Nguyen Van
authors.initials: NV
authors.lastname: Thanh
authors.affiliation: a Institute of Marine Biochemistry (IMBC) , Vietnam Academy of Science and Technology (VAST) , Hanoi , Vietnam.
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Cuong
authors.affiliation: a Institute of Marine Biochemistry (IMBC) , Vietnam Academy of Science and Technology (VAST) , Hanoi , Vietnam.
authors.forename: Nguyen Hoai
authors.initials: NH
authors.lastname: Nam
authors.affiliation: a Institute of Marine Biochemistry (IMBC) , Vietnam Academy of Science and Technology (VAST) , Hanoi , Vietnam.
authors.forename: Phan Van
authors.initials: PV
authors.lastname: Kiem
authors.affiliation: a Institute of Marine Biochemistry (IMBC) , Vietnam Academy of Science and Technology (VAST) , Hanoi , Vietnam.
authors.forename: Chau Van
authors.initials: CV
authors.lastname: Minh
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D056945:Hep G2 Cells; D006801:Humans; D007624:KB Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013215:Starfish / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000970:Antineoplastic Agents; D006027:Glycosides; D013256:Steroids; C000617253:pentaceroside A; C000617256:pentaceroside B
keywords: Oreasteridae; Pentaceraster gracilis; starfish; steroid glycoside