title: An efficient construction of N,N-bicyclic pyrazolidinones comprising enaminonitriles via asymmetric [3+2] cycloaddition.
abstract: The first thiourea catalysed asymmetric [3+2] cycloaddition reaction between azomethine imines and malanonitriles was developed. Using this novel synthetic strategy, hybrid molecules containing N,N-bicyclic pyrazolidinones fused with enaminonitriles were synthesized in good yields with excellent enantioselectivities (up to 98% ee).
authors.affiliation: Chemical Biology Laboratory, Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences Building, Indian Institute of Technology Madras, Chennai-600036, India. vkesavan@iitm.ac.in.
authors.forename: Manjunatha
authors.initials: M
authors.lastname: Vishwanath
authors.affiliation: Chemical Biology Laboratory, Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences Building, Indian Institute of Technology Madras, Chennai-600036, India. vkesavan@iitm.ac.in.
authors.forename: Koilpitchai
authors.initials: K
authors.lastname: Sivamuthuraman
authors.affiliation: Chemical Biology Laboratory, Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences Building, Indian Institute of Technology Madras, Chennai-600036, India. vkesavan@iitm.ac.in.
authors.forename: Venkitasamy
authors.initials: V
authors.lastname: Kesavan