title: Basic laboratory parameters as predictors of in-hospital death in patients with acute decompensated heart failure: data from a large single-centre cohort.
abstract: BACKGROUND
  Heart failure (HF) is a growing cause of hospitalisation worldwide, and despite significant progress in its treat-ment it is still associated with high mortality.
  
  
  OBJECTIVE
  The aim of this study was to find factors predicting in-hospital death in acute decompensated HF by analysis of basic laboratory data and echocardiography, routinely collected on admission to the hospital.
  
  
  METHODS
  To this single-centre retrospective study we involved 638 consecutive patients hospitalised in the years 2007-2008 due to acute decompensated HF. To the initial univariate analysis we included the results of echocardiography and 36 basic laboratory tests performed at hospital admission. Parameters significantly associated with in-hospital death in univariate analysis were taken to multivariate regression analysis.
  
  
  RESULTS
  In-hospital death occurred in 119 cases (median age 75 years; 40.3% females). The multivariate analysis revealed sig-nificant association between in-hospital death and: higher leukocyte count (death [D]: 13.5 vs. survival [S]: 8.8 G/L, p < 0.01), higher neutrophil count (D: 10.5 vs. S: 5.9 G/L, p < 0.01), lower lymphocyte count (D: 1.3 vs. S: 1.7 G/L, p < 0.05), higher C-reactive protein concentration (D: 20.8 vs. S: 6.7 mg/dL, p < 0.01), higher serum glucose concentration (D: 167.0 vs. S: 116.0 mg/dL, p < 0.00001), higher serum creatinine concentration (D: 1.5 vs. S: 1.2 mg/dL, p < 0.0001), higher blood urea nitrogen concentration (D: 29.0 vs. S: 22.0 mg/dL, p < 0.00001), and higher aspartate aminotransferase (D: 72.0 vs. S: 27.0 U/L, p < 0.0001). Surprisingly, there was no significant association with echocardiographic parameters.
  
  
  CONCLUSIONS
  Analysis of basic laboratory data collected on admission to the hospital may help to identify patients with acute decompensated HF, who are at high risk of in-hospital death.
authors.affiliation: Department of Principles of Clinical Medicine, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland. ostrowska.go@gmail.com.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Ostrowska
authors.forename: Adam
authors.initials: A
authors.lastname: Ostrowski
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Łuczak
authors.forename: Miłosz
authors.initials: M
authors.lastname: Jaguszewski
authors.forename: Piotr
authors.initials: P
authors.lastname: Adamski
authors.forename: Jerzy
authors.initials: J
authors.lastname: Bellwon
authors.forename: Andrzej
authors.initials: A
authors.lastname: Rynkiewicz
authors.forename: Marcin
authors.initials: M
authors.lastname: Gruchała
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose; D002097:C-Reactive Protein / Q000032:analysis*; D003404:Creatinine / Q000097:blood*; D004452:Echocardiography; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D017052:Hospital Mortality; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D001786:Blood Glucose; D002097:C-Reactive Protein; D003404:Creatinine
keywords: basic laboratory parameters; decompensated; heart failure; in-hospital death; mortality predictors