title: Immunotropic Properties of Immobilized Interferon-α2b.
abstract: Course treatment with IFN-α2b immobilized on polyethylene glycol stimulates phagocytic activity of peritoneal macrophages and neutrophils, enhances humoral immune response in CBA/CaLac mice, stimulates IL-4 synthesis, and suppresses IFN-γ production by mitogenstimulated splenocytes from experimental animals.
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerativ Medicine, Tomsk, Russia. sherstoboev_eu@pharmso.ru.
authors.forename: E Yu
authors.initials: EY
authors.lastname: Sherstoboev
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerativ Medicine, Tomsk, Russia.
authors.forename: O G
authors.initials: OG
authors.lastname: Shitikova
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerativ Medicine, Tomsk, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Masnaya
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerativ Medicine, Tomsk, Russia.
authors.forename: M G
authors.initials: MG
authors.lastname: Danilets
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerativ Medicine, Tomsk, Russia.
authors.forename: E S
authors.initials: ES
authors.lastname: Trofimova
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerativ Medicine, Tomsk, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Ligacheva
authors.affiliation: Siberian Center of Pharmacology and Biotechnology, Novosibirsk, Russia.
authors.forename: P G
authors.initials: PG
authors.lastname: Madonov
authors.affiliation: Siberian Center of Pharmacology and Biotechnology, Novosibirsk, Russia.
authors.forename: D N
authors.initials: DN
authors.lastname: Kinsht
authors.affiliation: Siberian Center of Pharmacology and Biotechnology, Novosibirsk, Russia.
authors.forename: K I
authors.initials: KI
authors.lastname: Ershov
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerativ Medicine, Tomsk, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Shilova
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D017951:Antigen Presentation / Q000187:drug effects; D002478:Cells, Cultured; D004337:Drug Carriers / Q000008:administration & dosage*; D004353:Drug Evaluation, Preclinical; D007111:Immunity, Cellular / Q000187:drug effects; D056724:Immunity, Humoral / Q000187:drug effects; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage*; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000276:immunology; D008297:Male; D008808:Mice, Inbred CBA; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D013154:Spleen / Q000187:drug effects; D013211:Staphylococcus aureus / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D004337:Drug Carriers; D000077190:Interferon alpha-2; D016898:Interferon-alpha; C000614170:Interferon-alpha2b; D011092:Polyethylene Glycols
keywords: cytokines; interferon-α2b; pegylation; phagocytosis