title: Amine-Mediated Transimination and Aromatization-Triggered Domino Reaction in the Synthesis of Polyfunctionalized 4-Aminoquinolines.
abstract: Dearomatization provides numerous possibilities for the development of new transformative modes of aromatic compounds. A conceptually novel metal-free multicomponent domino reaction of the dearomatized products of 2-alkynylanilines is developed. The reaction involves the secondary amine-mediated transimination with α-amino nitriles and subsequent aromatization-triggered cascade rearrangement, nucleophilic cyclization, and retro-Strecker reaction. This process provided a new practical method for the rapid synthesis of polyfunctionalized 4-aminoquinolines from readily available starting materials.
authors.affiliation: Department of Chemistry, Fudan University , 220 Handan Road, Shanghai, 200433, China.
authors.forename: Runzhe
authors.initials: R
authors.lastname: Song
authors.affiliation: Department of Chemistry, Fudan University , 220 Handan Road, Shanghai, 200433, China.
authors.forename: Zhaomeng
authors.initials: Z
authors.lastname: Han
authors.affiliation: Department of Chemistry, Fudan University , 220 Handan Road, Shanghai, 200433, China.
authors.forename: Qiuqin
authors.initials: Q
authors.lastname: He
authors.affiliation: Department of Chemistry, Fudan University , 220 Handan Road, Shanghai, 200433, China.
authors.forename: Renhua
authors.initials: R
authors.lastname: Fan