title: Emerging Systemic Therapies for the Management of Penile Cancer.
abstract: Penile squamous cell carcinoma (PSCC) is a rare cancer, but is more common in developing countries. Locally advanced and metastatic PSCC is associated with significant morbidity and mortality, with the prognosis remaining extremely poor. The authors searched PubMed and published abstracts for metastatic PSCC studies to describe emerging therapies. Multimodality treatment using chemotherapy, radiation, and consolidative surgery are standard of care. Utilizing anti-EGFR therapies and novel immunotheraputic approaches may help improve outcomes in PSCC.
authors.affiliation: Department of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN 55455, USA.
authors.forename: Shilpa
authors.initials: S
authors.lastname: Gupta
authors.affiliation: Section of Medical Oncology, Department of Medicine, UAB Comprehensive Cancer Center, 1802 6th Avenue South, NP2540B, Birmingham, AL 35294, USA. Electronic address: gsonpavde@uabmc.edu.
authors.forename: Guru
authors.initials: G
authors.lastname: Sonpavde
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000628:therapy*; D003131:Combined Modality Therapy; D019468:Disease Management; D006801:Humans; D008297:Male; D010412:Penile Neoplasms / Q000175:diagnosis / Q000628:therapy*; D011379:Prognosis
keywords: Chemotherapy; Combined modality therapy; EGFR; PD-1; Penile squamous cell carcinoma; Targeted therapy; VEGF