title: Basaloid squamous cell carcinoma arising in an inverted papilloma in the nasal cavity: A case report and review.
abstract: Basaloid squamous cell carcinoma (BSCC) is a histologically distinctive variant of squamous cell carcinoma comprising basal cell carcinoma and squamous cell carcinoma. BSCC is aggressive and shows a poor prognosis because of frequent lymph node invasion and distant metastases. BSCC preferentially occurs in the cervix, thymus, and esophagus and is uncommonly found in the head and neck region. BSCC in the nasal cavity or paranasal sinus is particularly rare. Inverted papilloma is an uncommon, benign tumor with a propensity to be associated with malignancy; however, BSCC arising in an inverted papilloma has never been reported. Here we report a case of a 56-year-old woman with BSCC arising in an inverted papilloma in the nasal cavity. The woman was referred to our hospital for epistaxis, nasal congestion, and dysphagia. A tumor was observed to completely occupy the left nasal cavity. The biopsy specimen was histologically diagnosed as papilloma. Computed tomography demonstrated a tumor with heterogeneous contrast effect occupying the left nasal cavity; however, extra-nasal tract extension was not observed. We performed endoscopic excision of the tumor. Microscopic findings confirmed the diagnosis of BSCC arising from an inverted papilloma. No tumor recurrence has been observed for 13 months after surgery.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Tottori University Faculty of Medicine, Yonago, Tottori, Japan. Electronic address: skoyama@med.tottori-u.ac.jp.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Koyama
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Tottori University Faculty of Medicine, Yonago, Tottori, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Nakamura
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Tottori University Faculty of Medicine, Yonago, Tottori, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Yokoyama
authors.affiliation: Center for Head and Neck Surgery, Kusatsu General Hospital, Kusatsu, Shiga, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Morisaki
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Tottori University Faculty of Medicine, Yonago, Tottori, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Fukuhara
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Tottori University Faculty of Medicine, Yonago, Tottori, Japan.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Fujiwara
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Tottori University Faculty of Medicine, Yonago, Tottori, Japan.
authors.forename: Hiroya
authors.initials: H
authors.lastname: Kitano
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Tottori University Faculty of Medicine, Yonago, Tottori, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Takeuchi
mesh_terms: D002280:Basal Cell Carcinoma / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009296:Nasal Cavity / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D009669:Nose Neoplasms / Q000473:pathology*; D018308:Papilloma, Inverted / Q000473:pathology*
keywords: Basaloid squamous cell carcinoma; Endoscopic surgery; Head and neck; Inverted papilloma; Nasal cavity