title: Electronic control of H+current in a bioprotonic device with Gramicidin A and Alamethicin.
abstract: In biological systems, intercellular communication is mediated by membrane proteins and ion channels that regulate traffic of ions and small molecules across cell membranes. A bioelectronic device with ion channels that control ionic flow across a supported lipid bilayer (SLB) should therefore be ideal for interfacing with biological systems. Here, we demonstrate a biotic-abiotic bioprotonic device with Pd contacts that regulates proton (H+) flow across an SLB incorporating the ion channels Gramicidin A (gA) and Alamethicin (ALM). We model the device characteristics using the Goldman-Hodgkin-Katz (GHK) solution to the Nernst-Planck equation for transport across the membrane. We derive the permeability for an SLB integrating gA and ALM and demonstrate pH control as a function of applied voltage and membrane permeability. This work opens the door to integrating more complex H+channels at the Pd contact interface to produce responsive biotic-abiotic devices with increased functionality.
authors.affiliation: Department of Electrical Engineering, University of California Santa Cruz, Santa Cruz, California 95064, USA.|Department of Materials Science and Engineering, University of Washington, Seattle, Washington 98195, USA.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Hemmatian
authors.affiliation: Department of Materials Science and Engineering, University of Washington, Seattle, Washington 98195, USA.
authors.forename: Scott
authors.initials: S
authors.lastname: Keene
authors.affiliation: Department of Materials Science and Engineering, University of Washington, Seattle, Washington 98195, USA.|Department of Electrical Engineering, University of Washington, Seattle, Washington 98195, USA.
authors.forename: Erik
authors.initials: E
authors.lastname: Josberger
authors.affiliation: Department of Electrical Engineering, University of California Santa Cruz, Santa Cruz, California 95064, USA.|Department of Materials Science and Engineering, University of Washington, Seattle, Washington 98195, USA.
authors.forename: Takeo
authors.initials: T
authors.lastname: Miyake
authors.affiliation: Department of Materials Science and Engineering, University of Washington, Seattle, Washington 98195, USA.
authors.forename: Carina
authors.initials: C
authors.lastname: Arboleda
authors.affiliation: Department of Chemical Engineering, University of Washington, Seattle, Washington 98195, USA.
authors.forename: Jessica
authors.initials: J
authors.lastname: Soto-Rodríguez
authors.affiliation: Department of Chemical Engineering, University of Washington, Seattle, Washington 98195, USA.
authors.forename: François
authors.initials: F
authors.lastname: Baneyx
authors.affiliation: Department of Electrical Engineering, University of California Santa Cruz, Santa Cruz, California 95064, USA.|Department of Materials Science and Engineering, University of Washington, Seattle, Washington 98195, USA.
authors.forename: Marco
authors.initials: M
authors.lastname: Rolandi
mesh_terms: D000408:Alamethicin / Q000737:chemistry*; D001692:Biological Transport / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism*; D004553:Electric Conductivity; D006096:Gramicidin / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007473:Ion Channels / Q000737:chemistry*; D007477:Ions / Q000378:metabolism*; D008051:Lipid Bilayers / Q000737:chemistry; D008564:Membrane Potentials / Q000502:physiology; D010539:Permeability; D011522:Protons; D000076251:Wearable Electronic Devices
chemical_list: D007473:Ion Channels; D007477:Ions; D008051:Lipid Bilayers; D011522:Protons; D006096:Gramicidin; D000408:Alamethicin