title: Iron-Mediated Domino Interrupted Iso-Nazarov/Dearomative (3 + 2)-Cycloaddition of Electrophilic Indoles.
abstract: An efficient domino reaction combining different classes of pericyclic reactions leads to chiral complex polycyclic indoline-based architectures from achiral starting materials under mild conditions. This practical method is based on the ability of iron(III) chloride to promote both 4π electrocyclizations of 2,4-dienals and the C2-C3 umpolung of N-acetylindoles during the dearomative (3 + 2) cycloadditions.
authors.affiliation: Institut Lavoisier Versailles, UMR CNRS 8180, Université de Versailles-St-Quentin-en-Yvelines, Université Paris Saclay , 45 Avenue des États-Unis, 78035 Versailles cedex, France.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Marques
authors.affiliation: Institut Lavoisier Versailles, UMR CNRS 8180, Université de Versailles-St-Quentin-en-Yvelines, Université Paris Saclay , 45 Avenue des États-Unis, 78035 Versailles cedex, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Coeffard
authors.affiliation: Normandie Univ, UNIROUEN, INSA Rouen, CNRS, COBRA (UMR 6014) , 76000 Rouen, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Chataigner
authors.affiliation: Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO), Equipe Méthodologie, Synthèse et Molécules Thérapeutiques (MS&MT), Université Paris Sud, CNRS, Université Paris Saclay , Bat. 410, 91405 Orsay, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Vincent
authors.affiliation: Institut Lavoisier Versailles, UMR CNRS 8180, Université de Versailles-St-Quentin-en-Yvelines, Université Paris Saclay , 45 Avenue des États-Unis, 78035 Versailles cedex, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Moreau