title: Diagnosis ofCapnocytophaga canimorsusSepsis by Whole-Genome Next-Generation Sequencing.
abstract: We report the case of a 60-year-old man with septic shock due toCapnocytophaga canimorsusthat was diagnosed in 24 hours by a novel whole-genome next-generation sequencing assay. This technology shows great promise in identifying fastidious pathogens, and, if validated, it has profound implications for infectious disease diagnosis.
authors.affiliation: Department of Medicine.
authors.forename: Maria K
authors.initials: MK
authors.lastname: Abril
authors.affiliation: Department of Medicine.
authors.forename: Adam S
authors.initials: AS
authors.lastname: Barnett
authors.affiliation: Department of Medicine.
authors.forename: Kara
authors.initials: K
authors.lastname: Wegermann
authors.affiliation: Department of Medicine.
authors.forename: Eric
authors.initials: E
authors.lastname: Fountain
authors.affiliation: Divisions of Infectious Diseases.
authors.forename: Andrew
authors.initials: A
authors.lastname: Strand
authors.affiliation: Hematology.
authors.forename: Benjamin M
authors.initials: BM
authors.lastname: Heyman
authors.affiliation: Pulmonary, Allergy, and Critical Care Medicine.
authors.forename: Britton A
authors.initials: BA
authors.lastname: Blough
authors.affiliation: Pulmonary, Allergy, and Critical Care Medicine.
authors.forename: Aparna C
authors.initials: AC
authors.lastname: Swaminathan
authors.affiliation: Divisions of Infectious Diseases.
authors.forename: Batu
authors.initials: B
authors.lastname: Sharma-Kuinkel
authors.affiliation: Divisions of Infectious Diseases.
authors.forename: Felicia
authors.initials: F
authors.lastname: Ruffin
authors.affiliation: Divisions of Infectious Diseases.
authors.forename: Barbara D
authors.initials: BD
authors.lastname: Alexander
authors.affiliation: Department of Pathology , Duke University Medical Center , Durham, North Carolina.
authors.forename: Chad M
authors.initials: CM
authors.lastname: McCall
authors.affiliation: Divisions of Infectious Diseases.
authors.forename: Sylvia F
authors.initials: SF
authors.lastname: Costa
authors.affiliation: Hematology.
authors.forename: Murat O
authors.initials: MO
authors.lastname: Arcasoy
authors.affiliation: Karius, Inc. , Menlo Park, California.
authors.forename: David K
authors.initials: DK
authors.lastname: Hong
authors.affiliation: Karius, Inc. , Menlo Park, California.
authors.forename: Timothy A
authors.initials: TA
authors.lastname: Blauwkamp
authors.affiliation: Karius, Inc. , Menlo Park, California.
authors.forename: Michael
authors.initials: M
authors.lastname: Kertesz
authors.affiliation: Divisions of Infectious Diseases.
authors.forename: Vance G
authors.initials: VG
authors.lastname: Fowler
authors.affiliation: Pulmonary, Allergy, and Critical Care Medicine.
authors.forename: Bryan D
authors.initials: BD
authors.lastname: Kraft
keywords: high-throughput nucleotide sequencing; microbiological techniques; sepsis/diagnosis