title: A facile approach for the synthesis of C13-C24 fragments of maltepolides A, C and D.
abstract: A linear, chiron approach for the synthesis of C13-C24 fragments of cytostatic maltepolides A, C and D consisting of a tetrahydrofuran subunit and a chiral alkenyl/alkyl substituent is achieved from (+)-diethyl l-tartrate. The other chiral stereocenters were generated by employing key reactions such as Crimmins aldol, alkynylation and CeCl3·7H2O mediated Luche reduction reactions.
authors.affiliation: Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India. srihari@iict.res.in.
authors.forename: P Sankara
authors.initials: PS
authors.lastname: Rao
authors.affiliation: Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India. srihari@iict.res.in.
authors.forename: P
authors.initials: P
authors.lastname: Srihari
mesh_terms: D000475:Alkenes / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic; D005663:Furans / Q000737:chemistry; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D061065:Polyketides / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D005663:Furans; D047028:Macrocyclic Compounds; D061065:Polyketides; C583984:maltepolide; C018674:tetrahydrofuran