title: Perip7lakin is a target for autoimmunity in asthma.
abstract: The role of autoimmunity targeting epithelial antigens in asthma has been suggested, in particular in non-atopic and severe asthma. Periplakin, a desmosomal component, is involved in epithelial cohesion and intracellular signaling. We detected anti-periplakin IgG antibodies in 47/260 (18 %) patients with asthma, with no association with severity or atopy. In addition, anti-periplakin IgE antibodies were detected in 12 of 138 tested patients (8.7 %) and were more frequently observed in patients with than without nasal polyposis. This study identifies a new autoimmune epithelial target in asthma. Whether periplakin autoimmunity (both IgG and IgE auto-antibodies) is involved in asthma pathogenesis remains to be studied during the disease course of these patients.
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, Service de Pneumologie et Centre de Compétence des Maladies Pulmonaires Rares, Paris, France. camille.taille@aphp.fr.|Département Hospitalo-Universitaire FIRE, Université Paris Diderot, Inserm UMR 1152, LabEx Inflamex, Paris, France. camille.taille@aphp.fr.
authors.forename: Camille
authors.identifier: 0000-0001-9768-5728
authors.initials: C
authors.lastname: Taillé
authors.affiliation: Assistance publique-Hôpitaux de Paris, Hôpital Bichat, Laboratoire d'immunologie « Autoimmunité et Hypersensibilités », Paris, France.
authors.forename: Sabine
authors.initials: S
authors.lastname: Grootenboer-Mignot
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, Unité de recherche clinique, département de biostatistiques, Paris, France.
authors.forename: Candice
authors.initials: C
authors.lastname: Estellat
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, Unité de recherche clinique, département de biostatistiques, Paris, France.
authors.forename: Carine
authors.initials: C
authors.lastname: Roy
authors.affiliation: Assistance publique-Hôpitaux de Paris, Hôpital Bichat, Laboratoire d'immunologie « Autoimmunité et Hypersensibilités », Paris, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Ly Ka So
authors.affiliation: Inserm UMR 1152, LabEx Inflamex, Paris, France.
authors.forename: Marina
authors.initials: M
authors.lastname: Pretolani
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, Service de Pneumologie et Centre de Compétence des Maladies Pulmonaires Rares, Paris, France.|Département Hospitalo-Universitaire FIRE, Université Paris Diderot, Inserm UMR 1152, LabEx Inflamex, Paris, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Aubier
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, Service de Pneumologie et Centre de Compétence des Maladies Pulmonaires Rares, Paris, France.|Département Hospitalo-Universitaire FIRE, Université Paris Diderot, Inserm UMR 1152, LabEx Inflamex, Paris, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Crestani
authors.affiliation: Assistance publique-Hôpitaux de Paris, Hôpital Bichat, Laboratoire d'immunologie « Autoimmunité et Hypersensibilités », Paris, France.|INSERM UMR996, Université Paris-Sud, Université Paris-Saclay, Chatenay-Malabry, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Chollet-Martin
mesh_terms: D000328:Adult; D001249:Asthma / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D015551:Autoimmunity; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000097:blood / Q000453:epidemiology / Q000276:immunology; D051179:Plakins / Q000276:immunology*; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D012698:Serologic Tests; D012720:Severity of Illness Index
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D007074:Immunoglobulin G; C491674:PPL protein, human; D051179:Plakins; D007073:Immunoglobulin E
keywords: Airway epithelium; Asthma; Autoimmunity; Desmosome; Nasal polyposis