title: Epigenetics in Cancer: A Hematological Perspective.
abstract: For several decades, we have known that epigenetic regulation is disrupted in cancer. Recently, an increasing body of data suggests epigenetics might be an intersection of current cancer research trends: next generation sequencing, immunology, metabolomics, and cell aging. The new emphasis on epigenetics is also related to the increasing production of drugs capable of interfering with epigenetic mechanisms and able to trigger clinical responses in even advanced phase patients. In this review, we will use myeloid malignancies as proof of concept examples of how epigenetic mechanisms can trigger or promote oncogenesis. We will also show how epigenetic mechanisms are related to genetic aberrations, and how they affect other systems, like immune response. Finally, we will show how we can try to influence the fate of cancer cells with epigenetic therapy.
authors.affiliation: Department of Internal Medicine, Section of Hematology, Yale School of Medicine, New Haven, Connecticut, United States of America.
authors.forename: Maximilian
authors.initials: M
authors.lastname: Stahl
authors.affiliation: Department of Internal Medicine, Section of Hematology, Yale School of Medicine, New Haven, Connecticut, United States of America.
authors.forename: Nathan
authors.identifier: http://orcid.org/0000-0002-6601-9412
authors.initials: N
authors.lastname: Kohrman
authors.affiliation: Department of Internal Medicine, Section of Hematology, Yale School of Medicine, New Haven, Connecticut, United States of America.
authors.forename: Steven D
authors.identifier: http://orcid.org/0000-0002-2349-2701
authors.initials: SD
authors.lastname: Gore
authors.affiliation: Department of Internal Medicine, Section of Hematology, Yale School of Medicine, New Haven, Connecticut, United States of America.
authors.forename: Tae Kon
authors.initials: TK
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Section of Hematology, Yale School of Medicine, New Haven, Connecticut, United States of America.
authors.forename: Amer M
authors.initials: AM
authors.lastname: Zeidan
authors.affiliation: Department of Internal Medicine, Section of Hematology, Yale Cancer Center at Yale University, New Haven, Connecticut, United States of America.
authors.forename: Thomas
authors.initials: T
authors.lastname: Prebet
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics; D019175:DNA Methylation / Q000235:genetics*; D044127:Epigenesis, Genetic; D019337:Hematologic Neoplasms / Q000235:genetics* / Q000473:pathology; D059014:High-Throughput Nucleotide Sequencing; D006657:Histones / Q000235:genetics; D006801:Humans
chemical_list: D006657:Histones