title: Triterpenoid-Based Self-Healing Supramolecular Polymer Hydrogels Formed by Host-Guest Interactions.
abstract: Pentacyclic triterpenoids, a class of naturally bioactive products having multiple functional groups, unique chiral centers, rigid skeletons, and good biocompatibility, are ideal building blocks for fabricating versatile supramolecular structures. In this research, the natural pentacyclic triterpenoid glycyrrhetinic acid (GA) was used as a guest molecule for β-cyclodextrin (β-CD) to form a GA/β-CD (1:1) inclusion complex. By means of GA and β-CD pendant groups in N,N'-dimethylacrylamide copolymers, a supramolecular polymer hydrogel can be physically cross-linked by host-guest interactions between GA and β-CD moieties. Moreover, self-healing of this hydrogel was observed and confirmed by step-strain rheological measurements, whereby the maximum storage modulus occurred at a [GA]/[β-CD] molar ratio of 1:1. Additionally, these polymers displayed outstanding biocompatibility. The introduction of a natural pentacyclic triterpenoid into a hydrogel system not only provides a biocompatible guest-host complementary GA/β-CD pair, but also makes this hydrogel an attractive candidate for tissue engineering.
authors.affiliation: State Key Lab of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P.R. China.|College of Chemistry and Material Science, Shandong Agricultural University, Tai'an, 271018, P. R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: State Key Lab of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P.R. China.|College of Chemistry and Material Science, Shandong Agricultural University, Tai'an, 271018, P. R. China.
authors.forename: Jianzuo
authors.initials: J
authors.lastname: Li
authors.affiliation: State Key Lab of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P.R. China.
authors.forename: Xia
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Macromolecular Science, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, P.R. China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Yan
authors.affiliation: Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology, Ministry of Education, Tsinghua University, Beijing, 100084, P. R. China.
authors.forename: Yuxia
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology, Ministry of Education, Tsinghua University, Beijing, 100084, P. R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Hao
authors.affiliation: State Key Lab of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Hu
authors.affiliation: Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology, Ministry of Education, Tsinghua University, Beijing, 100084, P. R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Ju
mesh_terms: D020100:Hydrogels / Q000737:chemistry*; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry*; D023822:Tissue Engineering; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D020100:Hydrogels; D011108:Polymers; D047392:beta-Cyclodextrins
keywords: cyclodextrins; gels; host-guest systems; self-healing materials; terpenoids