title: The Emerging Role of MRI in Prostate Cancer Active Surveillance and Ongoing Challenges.
abstract: OBJECTIVE
  Active surveillance (AS) has emerged as a management strategy for preventing overtreatment of indolent prostate cancer. Selection of patients for AS has traditionally proved challenging and resulted in 20-30% misclassification rates. MRI has potential to help overcome this limitation, broaden selection criteria to increase recruitment, and minimize the invasive nature of AS follow-up.
  
  
  CONCLUSIONS
  The main issues surrounding MRI and AS are the heterogeneity of inclusion criteria, the definition of significant disease, and agreement about what constitutes radiologic progression. Prospective cohorts with MRI at enrollment and long-term follow-up are required to further address these issues.
authors.affiliation: 1 Department of Radiology, Addenbrooke's Hospital and the University of Cambridge, Hills Rd, Cambridge, CB2 0QQ, UK.
authors.forename: Tristan
authors.initials: T
authors.lastname: Barrett
authors.affiliation: 2 Department of Medical Imaging, Sunnybrook Health Sciences Center and University of Toronto, Toronto, ON, Canada.
authors.forename: Masoom A
authors.initials: MA
authors.lastname: Haider
mesh_terms: D019317:Evidence-Based Medicine; D005544:Forecasting; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000639:trends*; D008297:Male; D009367:Neoplasm Staging; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D057832:Watchful Waiting / Q000379:methods*
keywords: active surveillance; multiparametric MRI; prostate cancer