title: Clinicobiochemical evaluation of turmeric with black pepper and nigella sativa in management of oral submucous fibrosis-a double-blind, randomized preliminary study.
abstract: OBJECTIVE
  To investigate the effectiveness of turmeric with black pepper and nigella sativa in oral submucous fibrosis (OSMF).
  
  
  METHODS
  Forty OSMF patients were randomly divided into two groups. The study was performed under a double-blind, randomized design. Group A received turmeric with black pepper and group B received nigella sativa for 3 months. Clinical evaluation was done every 15 days. Patients' serum superoxide dismutase (SOD) levels were assessed before and after treatment and also compared with healthy controls. The response to treatment was analyzed using analysis of variance, paired t test, and unpaired t test.
  
  
  RESULTS
  After the treatment, groups A and B showed 3.85 ± 0.22 mm and 3.6 ± 0.07 mm improvement in mouth opening, respectively (P < .01); 87.90% and 78.91% reduction in burning sensation, respectively (P < .01); and +0.62 U/mL and +0.74 U/mL improvement in serum SOD levels, respectively (P < .05). The maximum mouth opening achieved was 8 mm in group A and 7 mm in group B. The mean pretreatment SOD level for controls and patients was 3.61 ± 0.24 U/mL in group A and 2.63 ± 0.18 U/mL in group B.
  
  
  CONCLUSIONS
  Turmeric with black pepper and nigella sativa improved mouth opening, burning sensation, and SOD levels in the present OSMF study patients; however, further investigations are needed.
authors.affiliation: Department of Oral Medicine and Radiology, College of Dental Sciences, Davangere, Karnataka, India. Electronic address: Dr@pratikp.com.
authors.forename: Pratik R
authors.initials: PR
authors.lastname: Pipalia
authors.affiliation: Department of Oral Medicine and Radiology, College of Dental Sciences, Davangere, Karnataka, India.
authors.forename: Rajeshwari G
authors.initials: RG
authors.lastname: Annigeri
authors.affiliation: Department of Oral Medicine and Radiology, Seema Dental College, Rishikesh, Uttrakhand, India.
authors.forename: Ranjeeta
authors.initials: R
authors.lastname: Mehta
mesh_terms: D000328:Adult; D030024:Curcuma; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D031881:Nigella sativa; D009914:Oral Submucous Fibrosis / Q000188:drug therapy*; D029222:Piper nigrum; D013482:Superoxide Dismutase / Q000097:blood; D016896:Treatment Outcome
chemical_list: D013482:Superoxide Dismutase