title: Association between 1,25-dihydroxyvitamin D and left atrial diameter in pre-dialysis chronic kidney disease patients .
abstract: OBJECTIVE
  To investigate the correlation between serum 1,25-dihydroxyvitamin D (1,25D) levels and left atrial diameter (LAD) using echocardiography in pre-dialysis chronic kidney disease (CKD).
  
  
  METHODS
  From an initial population of 487 patients (109 met the exclusion criteria), a total of 378 patients with CKD stage 3a - 5 who had not undergone dialysis or kidney transplantation were included in the study. The relationship between serum 1,25D levels and LAD was examined. Moreover, factors that impacted LAD were extracted through stepwise multiple regression analyses.
  
  
  RESULTS
  Serum 1,25D levels correlated negatively with LAD, left ventricular end-diastolic diameter, interventricular septum thickness, end-diastolic volume, stroke volume, left ventricular mass index (LVMI), and E/e'. Stepwise multiple regression analyses revealed there was a significant relationship between serum 1,25D levels and LAD (regression coefficient = -0.070, p = 0.001). In the stratified analysis, serum 1,25D levels were associated with LAD in the LVMI < 125 g/m2(regression coefficient = -0.067, p = 0.038) and ejection fraction (EF) ≥ 60% groups (regression coefficient = -0.080, p = 0.004).
  
  
  CONCLUSIONS
  Serum 1,25D levels were independently associated with LAD in CKD patients; however, the association was not significant in patients with an EF < 60% and LVMI > 125 g/m2.
authors.forename: Daijo
authors.initials: D
authors.lastname: Inaguma
authors.forename: Hibiki
authors.initials: H
authors.lastname: Shinjo
authors.forename: Akihito
authors.initials: A
authors.lastname: Tanaka
authors.forename: Eri
authors.initials: E
authors.lastname: Ito
authors.forename: Naoki
authors.initials: N
authors.lastname: Kamegai
authors.forename: Akiko
authors.initials: A
authors.lastname: Kato
authors.forename: Minami
authors.initials: M
authors.lastname: Mizutani
authors.forename: Hiroya
authors.initials: H
authors.lastname: Shimogushi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Otsuka
authors.forename: Asami
authors.initials: A
authors.lastname: Takeda
authors.forename: Midori
authors.initials: M
authors.lastname: Hasegawa
authors.forename: Yukio
authors.initials: Y
authors.lastname: Yuzawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004452:Echocardiography; D005260:Female; D006325:Heart Atria / Q000033:anatomy & histology / Q000000981:diagnostic imaging*; D006346:Heart Septum / Q000000981:diagnostic imaging; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D013318:Stroke Volume; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D