title: Early Prognostic Factors for the Progress of Preeclampsia - Our Experience in the Period 2010-2011.
abstract: OBJECTIVE
  To determine the prognostic value of the low Pregnancy-associated plasma protein A (PAPP-A) levels in the early stages of pregnancy (11-13 weeks GA) independently and in combination with a Doppler test of the uterine arteries during the second half of pregnancy (22-23 weeks GA).
  
  
  METHODS
  The study covered the period 2010-2011 and included 106 pregnant women, aged 35-40, with a single child pregnancy. The research excluded pregnant women with anomalies of the fetus, smokers and women taking prophylactically low doses of aspirin.
  
  
  RESULTS
  Thirty-six pregnant women had PAPP-A level below 0.4 MoM, whereas 20 of them developed preeclampsia and 7 - early preeclampsia. The combination of the low PAPP-A values and the abnormal Doppler test of the uterine arteries is with a considerably better prognostic value in regards to the risk of developing preeclampsia.
  
  
  CONCLUSIONS
  The Doppler test is a non-invasive, quick and easy method for assessment of the uterine-placental blood flow.
authors.affiliation: Department of Obstetrics and Gynecology, Trakia University, Faculty of Medicine, Stara Zagora, Bulgaria.
authors.forename: Mariya
authors.initials: M
authors.lastname: Angelova
authors.affiliation: Department of Obstetrics and Gynecology, Trakia University, Faculty of Medicine, Stara Zagora, Bulgaria.
authors.forename: Ivan
authors.initials: I
authors.lastname: Todorov
authors.affiliation: Department of Obstetrics and Gynecology, Paraskev Stoyanov Medical University, Varna, Bulgaria.
authors.forename: Emil
authors.initials: E
authors.lastname: Kovachev
keywords: Body Mass Index; Doppler test; Preeclampsia; Pregnancy-associated plasma protein A