title: Screening for the metabolic syndrome in subjects with migraine.
abstract: Background Metabolic syndrome (MetS) and migraine are known to be associated. This study assessed the risk of MetS and its clinical characteristics in migraine with aura (MA) and without aura (MO) based on a large-scale cross-sectional survey. Methods The study material consisted of 751 participants in the Nutrition, Environment and CardioVascular Health (NESCaV) survey. Diagnosis of migraine was based on the ef-ID migraine questionnaire and MetS was defined according to the Revised-Adult Treatment Panel III criteria. Sociodemographic and risk factors were also recorded. Weighted logistic regression was used to assess the risk of MetS. Results After adjusting for stratification (gender, age, district) and other factors (smoking status, sedentary lifestyle, family history of stroke, myocardial infarction and hypertension), MA subjects were at higher risk of MetS (OR 3.45; 95% CI: 1.63-7.29) while MO individuals were not, when compared to non-migraineurs. When considering MetS components, MA was positively associated with low HDL-cholesterol (OR 2.26; 95% CI: 1.08-4.74), hyperglycemia (OR 2.77; 95% CI: 1.30-5.88) and abdominal obesity (OR 2.03; 95% CI: 1.07-3.86). Conclusion Migraineurs with aura are at higher risk of MetS, suggesting that these subjects, already more exposed to stroke, may benefit from a systematic screening for the metabolic syndrome.
authors.affiliation: 1 Department of Public Health, Liege University, Liege, Belgium.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Streel
authors.affiliation: 1 Department of Public Health, Liege University, Liege, Belgium.
authors.forename: Anne-Françoise
authors.initials: AF
authors.lastname: Donneau
authors.affiliation: 1 Department of Public Health, Liege University, Liege, Belgium.
authors.forename: Nadia
authors.initials: N
authors.lastname: Dardenne
authors.affiliation: 1 Department of Public Health, Liege University, Liege, Belgium.
authors.forename: Axelle
authors.initials: A
authors.lastname: Hoge
authors.affiliation: 1 Department of Public Health, Liege University, Liege, Belgium.
authors.forename: Adelin
authors.initials: A
authors.lastname: Albert
authors.affiliation: 2 Headache Research Unit, Department of Neurology - CHR Citadelle, Liege University, Liege, Belgium.
authors.forename: Jean
authors.initials: J
authors.lastname: Schoenen
authors.affiliation: 1 Department of Public Health, Liege University, Liege, Belgium.
authors.forename: Michèle
authors.initials: M
authors.lastname: Guillaume
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D020325:Migraine with Aura / Q000453:epidemiology*; D020326:Migraine without Aura / Q000453:epidemiology*; D015995:Prevalence; D055815:Young Adult
keywords: Metabolic syndrome; migraine with and without aura