title: Out of Many, One: Computational Reconstruction of Mouse Skin using Single-Cell Transcriptomics.
abstract: Mammalian skin is a complex and heterogeneous tissue with several distinct compartments and stem cell populations. Joost et al. (2016) now use single-cell RNaseq to comprehensively reconstruct this complexity, revealing spatial and pseudotemporal differences between transcriptional programs in distinct compartments and a common basal program in skin stem cell populations.
authors.affiliation: Department of Dermatology, Columbia University, New York, NY 10032, USA; Department of Systems Biology, Columbia University, New York, NY 10032, USA. Electronic address: jcc2162@columbia.edu.
authors.forename: James C
authors.initials: JC
authors.lastname: Chen
authors.affiliation: Department of Dermatology, Columbia University, New York, NY 10032, USA; Department of Genetics and Development, Columbia University, New York, NY 10032, USA. Electronic address: amc65@cumc.columbia.edu.
authors.forename: Angela M
authors.initials: AM
authors.lastname: Christiano
mesh_terms: D000818:Animals; D051379:Mice; D012867:Skin; D013234:Stem Cells