title: Multimodal Therapy in the Management of Advanced Penile Cancer.
abstract: A multimodal approach to therapy is increasingly used in treating men with advanced penile cancer. Adjuvant chemotherapy improves outcomes in chemotherapy-naïve men with node-positive positive disease, and neoadjuvant chemotherapy can downstage bulky nodal disease sufficiently to permit surgery and has the potential to offer durable long-term survival. However, there remain several unanswered questions in this field, and international collaboration in the form of clinical trials is required to optimize treatment and improve survival in men with advanced penile cancer.
authors.affiliation: Department of Internal Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.
authors.forename: Praful
authors.initials: P
authors.lastname: Ravi
authors.affiliation: Department of Oncology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address: pagliaro.lance@mayo.edu.
authors.forename: Lance C
authors.initials: LC
authors.lastname: Pagliaro
mesh_terms: D003131:Combined Modality Therapy; D019468:Disease Management; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D010412:Penile Neoplasms / Q000175:diagnosis / Q000628:therapy*
keywords: Adjuvant chemotherapy; Neoadjuvant chemotherapy; Penile cancer; Radiotherapy; Survival