title: A Comparative Study of Transmembrane Diffusion and Permeation of Ibuprofen across Synthetic Membranes Using Franz Diffusion Cells.
abstract: Synthetic membranes used in Franz diffusion cells for topical formulation quality assessment should provide least resistance to drug diffusion. In this study, the diffusion rates of ibuprofen across thirteen membranes were determined using Franz diffusion cells. Correlation of the membrane thickness, pore size and MWCO with drug fluxes was also made. The drug diffusion results showed that the porous membranes were categorized into high-flux (8-18 mg/cm²/h) and low-flux (0.1-3 mg/cm²/h) membranes. The drug fluxes did not show strong correlations (r² < 0.99) with membrane parameters. Synthetic membranes can give variable drug fluxes, thus investigators should be careful in choosing membrane for formulation quality assessment.
authors.affiliation: Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, 50300, Malaysia. nsfern@gmail.com.
authors.forename: Shiow-Fern
authors.initials: SF
authors.lastname: Ng
authors.affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Taylor Street, Glasgow G4 0NR, UK.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Rouse
authors.affiliation: GlaxoSmithKline, Pharmaceutical Development, Harlow, CM19 5AW, UK.
authors.forename: Dominic
authors.initials: D
authors.lastname: Sanderson
authors.affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Taylor Street, Glasgow G4 0NR, UK.
authors.forename: Gillian
authors.initials: G
authors.lastname: Eccleston
keywords: Franz diffusion cells; ibuprofen drug diffusion; in vitro absorption; synthetic membranes; transdermal absorption