title: Asymmetric chlorination of 4-substituted pyrazolones catalyzed by natural cinchona alkaloid.
abstract: A natural quinidine-catalyzed asymmetric chlorination of 4-substituted pyrazolones is developed, affording products with a quaternary chiral chlorine-attached carbon centre in high yield with excellent enantioselectivity. The low catalyst loading (1 mol%), broad substrate scope, and facile and valuable transformation of the product highlight the practical utility of this process.
authors.affiliation: State Key Laboratory of Fine Chemicals, School of Pharmaceutical Science and Technology, Dalian University of Technology, Dalian 116024, P. R. China. bmwang@dlut.edu.cn.
authors.forename: Xiaoze
authors.initials: X
authors.lastname: Bao
authors.affiliation: State Key Laboratory of Fine Chemicals, School of Pharmaceutical Science and Technology, Dalian University of Technology, Dalian 116024, P. R. China. bmwang@dlut.edu.cn.
authors.forename: Shiqiang
authors.initials: S
authors.lastname: Wei
authors.affiliation: State Key Laboratory of Fine Chemicals, School of Pharmaceutical Science and Technology, Dalian University of Technology, Dalian 116024, P. R. China. bmwang@dlut.edu.cn.
authors.forename: Liwei
authors.initials: L
authors.lastname: Zou
authors.affiliation: State Key Laboratory of Fine Chemicals, School of Pharmaceutical Science and Technology, Dalian University of Technology, Dalian 116024, P. R. China. bmwang@dlut.edu.cn.
authors.forename: Yuli
authors.initials: Y
authors.lastname: He
authors.affiliation: State Key Laboratory of Fine Chemicals, School of Pharmaceutical Science and Technology, Dalian University of Technology, Dalian 116024, P. R. China. bmwang@dlut.edu.cn.
authors.forename: Fuzhao
authors.initials: F
authors.lastname: Xue
authors.affiliation: State Key Laboratory of Fine Chemicals, School of Pharmaceutical Science and Technology, Dalian University of Technology, Dalian 116024, P. R. China. bmwang@dlut.edu.cn.
authors.forename: Jingping
authors.initials: J
authors.lastname: Qu
authors.affiliation: State Key Laboratory of Fine Chemicals, School of Pharmaceutical Science and Technology, Dalian University of Technology, Dalian 116024, P. R. China. bmwang@dlut.edu.cn.
authors.forename: Baomin
authors.initials: B
authors.lastname: Wang