title: Propylthiouracil-induced alveolar hemorrhage.
abstract: Thionamide induced vasculitis is a multisystem disease. The patients may present with different clinical signs and findings due to organ involvement. These patients are almost always perinuclear antineutrophil cytoplasmic antibody (pANCA) or antimyeloperoxidase (MPO) positive. Clinical findings are not seen in all of the patients who are ANCA positive while using thionamide. Although symptoms usually resolve with drug discontinuation, some patients, however, require high-dose steroids, immunosuppressants, or plasmapheresis. We present here a case of alveolar hemorrhage induced by propilthiouracil (PTU) during treatment with PTU for Graves' disease; patients completely recovered with corticosteroid, cyclophosphamide, and plasmapheresis.
authors.affiliation: Department of Internal Medicine, Division of Endocrinology and Metabolism, Süleyman Demirel University Faculty of Medicine, Isparta, Turkey.
authors.forename: Bünyamin
authors.initials: B
authors.lastname: Aydın
authors.affiliation: Department of Internal Medicine, Division of Endocrinology and Metabolism, Süleyman Demirel University Faculty of Medicine, Isparta, Turkey.
authors.forename: Oğuzhan
authors.initials: O
authors.lastname: Aksu
authors.affiliation: Department of Internal Medicine, Süleyman Demirel University Faculty of Medicine, Isparta, Turkey.
authors.forename: Hasret
authors.initials: H
authors.lastname: Kacemer
authors.affiliation: Department of Internal Medicine, Division of Endocrinology and Metabolism, Süleyman Demirel University Faculty of Medicine, Isparta, Turkey.
authors.forename: Halil
authors.initials: H
authors.lastname: Demirkan
authors.affiliation: Department of Internal Medicine, Division of Nephrology, Süleyman Demirel University Faculty of Medicine, Isparta, Turkey.
authors.forename: Atilla
authors.initials: A
authors.lastname: Altuntaş
authors.affiliation: Department of Chest Disease, Süleyman Demirel University Faculty of Medicine, Isparta, Turkey.
authors.forename: Nigar
authors.initials: N
authors.lastname: Dirican
authors.affiliation: Department of Internal Medicine, Division of Endocrinology and Metabolism, Süleyman Demirel University Faculty of Medicine, Isparta, Turkey.
authors.forename: Banu Kale
authors.initials: BK
authors.lastname: Köroğlu
authors.affiliation: Department of Internal Medicine, Division of Rheumatology, Süleyman Demirel University Faculty of Medicine, Isparta, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Şahin
keywords: ANCA; Vasculitis; propylthiouracil