title: Low Density Lipoprotein Cholesterol and the Outcome of Acute Ischemic Stroke: Results of a Large Hospital-Based Study.
abstract: Studies show inconsistent associations between low-density lipoprotein cholesterol (LDL-C) and stroke outcome. We assessed these associations among patients with first-ever acute ischemic stroke (AIS) in China. Patients with first-ever AIS were categorized into 3 groups: normal LDL, marginally elevated LDL and high LDL - according to the LDL-C values on admission. The outcome measures that were investigated in each group included mortality, dependence and recurrence of vascular events. Patients with high LDL-C had higher mortality rates than did those with normal LDL-C at both 12 and 36 months, but this difference disappeared after adjustment for covariates. There was no difference between groups in mortality at 3 months and dependency or recurrence at 3, 12 or 36 months. LDL-C level was associated with long-term mortality after stroke, but was not an independent prognostic factor.
authors.affiliation: Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Xing
authors.forename: Zhongping
authors.initials: Z
authors.lastname: An
authors.forename: Ning
authors.initials: N
authors.lastname: Yu
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Zhao
authors.forename: Xianjia
authors.initials: X
authors.lastname: Ning
authors.forename: Jinghua
authors.initials: J
authors.lastname: Wang
mesh_terms: D000368:Aged; D002681:China; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012008:Recurrence; D012307:Risk Factors; D020521:Stroke / Q000097:blood* / Q000401:mortality*
chemical_list: D008078:Cholesterol, LDL