title: Interface modified polylactic acid/starch/poly ε-caprolactone antibacterial nanocomposite blends for medical applications.
abstract: In this study, an optimized interface-modified ternary blend with antibacterial activity based on polylactic acid/starch/poly ε-caprolactone (PLASCL20), mixed with nano hydroxyapatite (nHA) via melt blending. This method results in a homogeneous nanocomposite blend in which the addition of 3% nHA improves the overall properties such as hydrolytic degradation, hydrophilicity, antibacterial activity and the drug release comparing to PLASCL20. Moreover, the simultaneous use of nHA and encapsulated triclosan (LATC30) compensated the negative effect of triclosan through increasing the possible cell attachment. According to the contact angle results, nHA was thermodynamically driven into the interface of PLA and PCL/Starch phases. The addition of 3% nHA showed a good adjustment between the hydrolytic degradation and the release profile, therefore, their electrospun microfibers demonstrated an improved fibroblast (L929) cell attachment. The aforementioned nanocomposite blend is a suitable antibacterial candidate for many medical applications with minimum side effects due to the controlled release of triclosan.
authors.affiliation: Department of Chemical Engineering, Faculty of Engineering, Central Tehran Branch, Islamic Azad University, P.O. Box 13185-768, Tehran, Iran. Electronic address: mohdvi@gmail.com.
authors.forename: Seyed Mohammad
authors.initials: SM
authors.lastname: Davachi
authors.affiliation: Applied Science Nano Research Group, ASNARKA, P.C. 1619948753 Tehran, Iran.
authors.forename: Behzad
authors.initials: B
authors.lastname: Shiroud Heidari
authors.affiliation: Applied Science Nano Research Group, ASNARKA, P.C. 1619948753 Tehran, Iran.
authors.forename: Iman
authors.initials: I
authors.lastname: Hejazi
authors.affiliation: Department of Chemical Engineering, Shahrood Branch, Islamic Azad University, P.O. Box 36155-163, Shahrood, Iran.
authors.forename: Javad
authors.initials: J
authors.lastname: Seyfi
authors.affiliation: Applied Science Nano Research Group, ASNARKA, P.C. 1619948753 Tehran, Iran.
authors.forename: Erfan
authors.initials: E
authors.lastname: Oliaei
authors.affiliation: Applied Science Nano Research Group, ASNARKA, P.C. 1619948753 Tehran, Iran.
authors.forename: Arman
authors.initials: A
authors.lastname: Farzaneh
authors.affiliation: Department of Biotechnology, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Rashedi
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D061252:Feeder Cells; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D053761:Nanocomposites; D011091:Polyesters / Q000737:chemistry*; D013213:Starch / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D011091:Polyesters; C016240:polycaprolactone; C033616:poly(lactide); D013213:Starch
keywords: Antibacterial; Interface modified blend; Nano hydroxyapatite; PCL; PLA; Starch