title: Influence of interleukin-18 gene polymorphisms on acute pancreatitis susceptibility in a Chinese population.
abstract: We investigate the relationship between IL-18 -607C/A and -137G/C genetic polymorphisms and development of acute pancreatitis in a Chinese population. A total of 153 patients were consecutively recruited from the First Affiliated Hospital of Chongqing Medical University between January 2013 and November 2014. Genotyping of IL-18 -607C/A and -137G/C variants was performed using the polymerase chain reaction-restriction fragment length polymorphism method. We observed a significant difference between acute pancreatitis patients and control subjects with respect to age (t = 2.15, P = 0.02), gender (chi-square = 3.95, P = 0.04), body mass index (t = 5.85, P < 0.001), and alcohol consumption (chi-square = 9.74, P = 0.002). Using chi-square tests, we found that the genotype distributions of IL-18 -607C/A (chi-square = 0.81, P = 0.67) and -137G/C (chi-square = 1.16, P = 0.56) polymorphisms did not differ between the acute pancreatitis and control groups. Genotype frequencies of these variants were consistent with Hardy-Weinberg equilibrium in both patient and control groups. In addition, logistic regression analysis failed to identify a significant association between these polymorphisms and acute pancreatitis risk. Our study firstly examined their association in a Chinese population, and we suggest that the IL-18 -607C/A and -137G/ C polymorphisms do not influence susceptibility to acute pancreatitis in the Chinese population studied in the present study.
authors.affiliation: Department of Emergency, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: H B
authors.initials: HB
authors.lastname: Gui
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: X G
authors.initials: XG
authors.lastname: Du
authors.affiliation: Department of Prosthodontics, The Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing, China.
authors.forename: Z H
authors.initials: ZH
authors.lastname: Fu
authors.affiliation: Department of Emergency, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China chenxmm66@163.com.
authors.forename: X M
authors.initials: XM
authors.lastname: Chen
mesh_terms: D000208:Acute Disease; D000367:Age Factors; D000368:Aged; D000483:Alleles; D044466:Asian People; D015992:Body Mass Index; D016022:Case-Control Studies; D004198:Disease Susceptibility; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D020382:Interleukin-18 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D012737:Sex Factors
chemical_list: D020382:Interleukin-18