title: Accuracy and interobserver agreement of diffusion-weighted imaging in pediatric inflammatory bowel disease.
abstract: OBJECTIVE
  To determine interobserver agreement (IOA) and accuracy of conventional MR enterography (MRE), qualitative diffusion, and apparent diffusion coefficient (ADC) values for detecting clinically active inflammation.
  
  
  METHODS
  MREs in 57 consecutive children with suspected inflammatory bowel disease were retrospectively reviewed.
  
  
  RESULTS
  Substantial IOA for conventional MRE (kappa=0.65) and qualitative diffusion (kappa=0.64), but fair to good IOA for ADC, (intra-class coefficient=0.63) were seen. Conventional MRE detected active clinical inflammation well (area under curve [AUC] 0.725), while qualitative diffusion and ADC did not perform well (AUC=0.572 and 0.461, respectively).
  
  
  CONCLUSIONS
  DWI can be helpful in diagnosing inflammatory bowel disease but does not perform well in identifying those with active inflammation.
authors.affiliation: Department of Diagnostic Imaging, The Hospital For Sick Children and Medical Imaging, University Of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.
authors.forename: Zehour
authors.initials: Z
authors.lastname: AlSabban
authors.affiliation: Division of Gastroenterology, Hepatology and Nutrition, The Hospital For Sick Children and Medical Imaging, University Of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.
authors.forename: Peter
authors.initials: P
authors.lastname: Church
authors.affiliation: Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Rahim
authors.initials: R
authors.lastname: Moineddin
authors.affiliation: Department of Diagnostic Imaging, The Hospital For Sick Children and Medical Imaging, University Of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.
authors.forename: Oscar M
authors.initials: OM
authors.lastname: Navarro
authors.affiliation: Department of Diagnostic Imaging, The Hospital For Sick Children and Medical Imaging, University Of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.
authors.forename: Mary-Louise
authors.initials: ML
authors.lastname: Greer
authors.affiliation: Division of Gastroenterology, Hepatology and Nutrition, The Hospital For Sick Children and Medical Imaging, University Of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.
authors.forename: Thomas
authors.initials: T
authors.lastname: Walters
authors.affiliation: Department of Diagnostic Imaging, The Hospital For Sick Children and Medical Imaging, University Of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada. Electronic address: govind.chavhan@sickkids.ca.
authors.forename: Govind B
authors.initials: GB
authors.lastname: Chavhan
mesh_terms: D000293:Adolescent; D019540:Area Under Curve; D002648:Child; D002675:Child, Preschool; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D041981:Gastrointestinal Tract / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D015588:Observer Variation; D015203:Reproducibility of Results; D012189:Retrospective Studies
keywords: Children; Diffusion-weighted imaging; Inflammatory bowel disease; MRE