title: Protective effects of oxymatrine against arsenic trioxide-induced liver injury.
abstract: Oxymatrine, a quinolizidine natural drug extracted from Sophora japonica, has been reported to have neuroprotective effect and cardioprotective effect. However, the protective effect of oxymatrine on arsenic trioxide (As2O3)-induced liver injury has not been reported. In the present study, we investigated the protective effects of oxymatrine on As2O3-induced liver injury in rats. Male Wistar rats were administrated 3mg/kg As2O3 intravenous injection on alternate days for 4 days. Oxymatrine was given 1 h before As2O3 treatment. The results showed that oxymatrine inhibited As2O3-induced hepatic pathological damage, liver ROS level and MDA level in a dose-dependent manner. As2O3 decreased the antioxidant enzymes SOD, GPX, and CAT activity and the decrease was inhibited by treatment of oxymatrine. Furthermore, oxymatrine attenuated the retention of arsenic in liver tissues and improved the expression of Nrf2 and HO-1. In conclusion, our results suggested that oxymatrine protected against As2O3-induced oxidative damage by activating Nrf2/HO-1 signaling pathway.
authors.affiliation: Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Qinghai
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Long
authors.initials: L
authors.lastname: Fan
authors.affiliation: Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xiao
authors.affiliation: Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Weiguang
authors.initials: W
authors.lastname: Ye
authors.affiliation: Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Lan
authors.affiliation: Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Jia
authors.affiliation: Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Feng
authors.affiliation: Department of Anatomy & Histology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
authors.forename: Changman
authors.initials: C
authors.lastname: Zhou
authors.affiliation: Department of Anesthesiology, the First Affiliated Hospital of Xinxiang Medical University, Henan, China.
authors.forename: Xiuqin
authors.initials: X
authors.lastname: Yue
authors.affiliation: Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, China.
authors.forename: Guogang
authors.initials: G
authors.lastname: Xing
authors.affiliation: Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Tianlong
authors.initials: T
authors.lastname: Wang
mesh_terms: D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D000077237:Arsenic Trioxide; D001152:Arsenicals; D015153:Blotting, Western; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000517:prevention & control*; D004195:Disease Models, Animal; D051547:Heme Oxygenase-1 / Q000378:metabolism; D008297:Male; D051267:NF-E2-Related Factor 2 / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D010087:Oxides / Q000633:toxicity*; D011807:Quinolizines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction / Q000187:drug effects; D000093842:Matrines
chemical_list: D000470:Alkaloids; D000975:Antioxidants; D000077237:Arsenic Trioxide; D001152:Arsenicals; D051547:Heme Oxygenase-1; D051267:NF-E2-Related Factor 2; D010087:Oxides; D011807:Quinolizines; C037573:oxymatrine; D000093842:Matrines
keywords: HO-1; Nrf-2; arsenic trioxide; liver; oxymatrine