title: Intra-Arterial Delivery of Idarubicin in Two Patients with Glioblastoma.
abstract: There is no effective treatment for recurrent glioblastoma (GB) when temozolomide-based radiochemotherapy fails. In theory, intra-arterial (IA) delivery of cytotoxic agents could achieve higher drug concentrations in tumors compared to intravenous injection. Moreover, choosing a highly lipid-soluble drug could make the most of the first-pass effect. Here, we evaluated idarubicin (IDA), a lipophilic anthracycline, in an in vitro assay using four human GB cell lines and compared it with 11 other drugs previously used for the IA treatment of brain tumors. Despite impressive in vitro cytotoxicity, IA IDA did not produce a beneficial effect in 2 patients with recurrent GB.
authors.affiliation: Department of Medical Oncology, University Hospital, Amiens, France.
authors.forename: Mohamad
authors.initials: M
authors.lastname: Chehimi
authors.affiliation: Department of Medical Oncology, University Hospital, Amiens, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Boone
authors.affiliation: Department of Radiology, University Hospital, Amiens, France.
authors.forename: Cyril
authors.initials: C
authors.lastname: Chivot
authors.affiliation: Department of Radiology, University Hospital, Amiens, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Deramond
authors.affiliation: Department of Radiology, University Hospital, Amiens, France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Constans
authors.affiliation: Department of Medical Oncology, University Hospital, Amiens, France.
authors.forename: Mony Chenda
authors.initials: MC
authors.lastname: Ly
authors.affiliation: Department of Medical Oncology, University Hospital, Amiens, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Chauffert
keywords: Glioblastoma; Idarubicin; Intra-arterial chemotherapy