title: Synthesis, antibacterial and antifungal possession of amino acids containing sulfonamide moieties.
abstract: Sulfonamides were developed by the simple reaction of amino acid with p-toluenesulfonyl chloride and structures of the new products (2a, 2b and 2c) were confirmed by elemental and spectral analysis (FT-IR, 1HNMR and13CNMR). In vitro, developed compounds were screened for their antibacterial and antifungal activities against two sensitive bacteria belonging to both gram positive and gram-negative types and two fungi. The synthesized sulfonamides (2a, 2b, 2c) exhibited excellent antifungal activities against the tested fungi. Among the tested compounds 2a and 2b have marked activity against E. coli with zone of inhibition (mm) 22.3±0.11and 20.2±0.26 (MIC: 12.5µg/mL, 12.5µg/mL) and S. aureus with zone of inhibition (mm) 20.2±0.26 and 23.2±0.55 (MIC: 12.5µg/mL, 6.25µg/mL). Compound 2c is moderately efficient towards E. coli (zone of inhibition (mm) 14.2±0.64, MIC: 100µg/mL) and no activity against S. aureus.
authors.affiliation: Institute of chemistry, University of Punjab, Lahore, Pakistan.
authors.forename: Muhammad Abdul
authors.initials: MA
authors.lastname: Qadir
authors.affiliation: Institute of chemistry, University of Punjab, Lahore, Pakistan.
authors.forename: Mahmood
authors.initials: M
authors.lastname: Ahmed
authors.affiliation: Govt Kinnaird College, Lahore, Pakistan.
authors.forename: Anum
authors.initials: A
authors.lastname: Khaleeq
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001231:Aspergillus flavus / Q000187:drug effects / Q000254:growth & development; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D002855:Chromatography, Thin Layer; D052978:Disk Diffusion Antimicrobial Tests; D004339:Drug Compounding; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D015394:Molecular Structure; D066244:Proton Magnetic Resonance Spectroscopy; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000596:Amino Acids; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D013449:Sulfonamides