title: Mitochondrial Ribosomal Protein L10 Associates with Cyclin B1/Cdk1 Activity and Mitochondrial Function.
abstract: Mitochondrial ribosomal proteins are important for mitochondrial-encoded protein synthesis and mitochondrial function. In addition to their roles in mitoribosome assembly, several mitochondrial ribosome proteins are also implicated in cellular processes like cell cycle regulation, apoptosis, and mitochondrial homeostasis regulation. Here, we demonstrate that MRPL10 regulates cyclin B1/Cdk1 (cyclin-dependent kinase 1) activity and mitochondrial protein synthesis in mammalian cells. In Drosophila, inactivation of mRpL10 (the Drosophila ortholog of mammalian MRPL10) in eyes results in abnormal eye development. Furthermore, expression of human cyclin B1 suppresses eye phenotypes and mitochondrial abnormality of mRpL10 knockdown Drosophila. This study identified that the physiological regulatory pathway of MRPL10 and providing new insights into the role of MRPL10 in growth control and mitochondrial function.
authors.affiliation: 1 Department of Ophthalmology, Xiangya Hospital, Central South University , Changsha, China .|2 The State Key Laboratory of Medical Genetics, School of Life Sciences, Central South University , Changsha, China .
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Li
authors.affiliation: 2 The State Key Laboratory of Medical Genetics, School of Life Sciences, Central South University , Changsha, China .
authors.forename: Ruo-Xi
authors.initials: RX
authors.lastname: Wang
authors.affiliation: 1 Department of Ophthalmology, Xiangya Hospital, Central South University , Changsha, China .
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Jiang
authors.affiliation: 1 Department of Ophthalmology, Xiangya Hospital, Central South University , Changsha, China .
authors.forename: En-Dong
authors.initials: ED
authors.lastname: Zhang
authors.affiliation: 2 The State Key Laboratory of Medical Genetics, School of Life Sciences, Central South University , Changsha, China .
authors.forename: Jie-Qiong
authors.initials: JQ
authors.lastname: Tan
authors.affiliation: 1 Department of Ophthalmology, Xiangya Hospital, Central South University , Changsha, China .
authors.forename: Hui-Zhuo
authors.initials: HZ
authors.lastname: Xu
authors.affiliation: 3 Department of Oncology, Xiangya Hospital, Central South University , Changsha, China .
authors.forename: Rong-Rong
authors.initials: RR
authors.lastname: Zhou
authors.affiliation: 1 Department of Ophthalmology, Xiangya Hospital, Central South University , Changsha, China .
authors.forename: Xiao-Bo
authors.initials: XB
authors.lastname: Xia
mesh_terms: D017209:Apoptosis / Q000502:physiology; D016203:CDC2 Protein Kinase; D002478:Cells, Cultured; D056744:Cyclin B1 / Q000378:metabolism*; D018844:Cyclin-Dependent Kinases / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000378:metabolism*; D010766:Phosphorylation; D000080882:Ribosomal Protein L10; D012269:Ribosomal Proteins / Q000378:metabolism*
chemical_list: D056744:Cyclin B1; D024101:Mitochondrial Proteins; C000630686:RPL10 protein, human; D012269:Ribosomal Proteins; D016203:CDC2 Protein Kinase; C528899:CDK1 protein, human; D018844:Cyclin-Dependent Kinases
keywords: Drp1; MRPL10; cyclin B1; mitochondrial fission