title: Methodological Considerations about the Use of Bimodal Oddball P300 in Psychiatry: Topography and Reference Effect.
abstract: Event-related potentials (ERPs) bimodal oddball task has disclosed increased sensitivity to show P300 modulations to subclinical symptoms. Even if the utility of such a procedure has still to be confirmed at a clinical level, gathering normative values of this new oddball variant may be of the greatest interest. We specifically addressed the challenge of defining the best location for the recording of P3a and P3b components and selecting the best reference to use by investigating the effect of an oﬄine re-reference procedure on recorded bimodal P3a and P3b. Forty young and healthy subjects were submitted to a bimodal (synchronized and always congruent visual and auditory stimuli) three-stimulus oddball task in which 140 frequent bimodal stimuli, 30 deviant "target" stimuli and 30 distractors were presented. Task consisted in clicking as soon as possible on the targets, and not paying attention to frequent stimuli and distractors. This procedure allowed us to record, for each individual, the P3a component, referring to the novelty process related to distractors processing, and the P3b component, linked to the processing of the target stimuli. Results showed that both P3a and P3b showed maximal amplitude in Pz. However, P3a displayed a more central distribution. Nose reference was also shown to give maximal amplitudes compared with average and linked mastoids references. These data were discussed in light of the necessity to develop multi-site recording guidelines to furnish sets of ERPs data comparable across laboratories.
authors.affiliation: Laboratory of Psychological Medicine and Addiction, ULB Neuroscience Institute, CHU Brugmann - Université Libre de Bruxelles Brussels, Belgium.
authors.forename: Elisa
authors.initials: E
authors.lastname: Schröder
authors.affiliation: Laboratory of Psychological Medicine and Addiction, ULB Neuroscience Institute, CHU Brugmann - Université Libre de Bruxelles Brussels, Belgium.
authors.forename: Hendrik
authors.initials: H
authors.lastname: Kajosch
authors.affiliation: Laboratory of Psychological Medicine and Addiction, ULB Neuroscience Institute, CHU Brugmann - Université Libre de Bruxelles Brussels, Belgium.
authors.forename: Paul
authors.initials: P
authors.lastname: Verbanck
authors.affiliation: Laboratory of Psychological Medicine and Addiction, ULB Neuroscience Institute, CHU Brugmann - Université Libre de Bruxelles Brussels, Belgium.
authors.forename: Charles
authors.initials: C
authors.lastname: Kornreich
authors.affiliation: Laboratory of Psychological Medicine and Addiction, ULB Neuroscience Institute, CHU Brugmann - Université Libre de Bruxelles Brussels, Belgium.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Campanella
keywords: P3a; P3b; bimodal P300; event-related potentials; reference; topography