title: Commercial vaccines provide limited protection to NADC30-like PRRSV infection.
abstract: NADC30-like PRRSV has been recently reported and became endemic in vaccinated pig herds in China. The outbreaks of disease in vaccinated pigs indicated the inefficacy of commercial PRRSV vaccines. In this study, five commercial PRRSV vaccines that have been widely used in China were used to evaluate the efficacy to a NADC30-like PRRSV infection. The vaccinated pigs were challenged with HNjz15, a NADC30-like PRRSV at 28days post vaccination. Compared to unvaccinated pigs, the vaccinated pigs clinically shortened the period of fever with less pig numbers of clinical manifestations and had improved body weight gain at the end of the study. However, the vaccinated pigs developed viremia with similar kinetics and suffered pathological lesions in lung and lymphoid tissues as the unvaccinated pigs. The virus load in tonsil, lung and lymph nodes detected by immunohistochemistry staining in vaccinated pigs was also similar to that in unvaccinated pigs which indicated the inability of vaccination to eradicate the virus from tissues of vaccinated pigs. Therefore, the above results suggested current commercial PRRSV vaccines could not provide complete protection to the NADC30-like PRRSV infection.
authors.affiliation: National Research Center for Veterinary Medicine, High-Tech District, Luoyang, China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Bai
authors.affiliation: National Research Center for Veterinary Medicine, High-Tech District, Luoyang, China.
authors.forename: Yuzhou
authors.initials: Y
authors.lastname: Wang
authors.affiliation: National Research Center for Veterinary Medicine, High-Tech District, Luoyang, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Xu
authors.affiliation: National Research Center for Veterinary Medicine, High-Tech District, Luoyang, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Sun
authors.affiliation: National Research Center for Veterinary Medicine, High-Tech District, Luoyang, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: National Research Center for Veterinary Medicine, High-Tech District, Luoyang, China.
authors.forename: Guobiao
authors.initials: G
authors.lastname: Ji
authors.affiliation: National Research Center for Veterinary Medicine, High-Tech District, Luoyang, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Li
authors.affiliation: National Research Center for Veterinary Medicine, High-Tech District, Luoyang, China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Tan
authors.affiliation: National Research Center for Veterinary Medicine, High-Tech District, Luoyang, China. Electronic address: xiaonanzhong@163.com.
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Li
authors.affiliation: College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, China; National Research Center for Veterinary Medicine, High-Tech District, Luoyang, China; OIE Porcine Reproductive and Respiratory Syndrome Laboratory, Beijing, China. Electronic address: tiankg@263.net.
authors.forename: Kegong
authors.initials: K
authors.lastname: Tian
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks; D008168:Lung / Q000473:pathology / Q000821:virology; D014066:Palatine Tonsil / Q000821:virology; D019318:Porcine Reproductive and Respiratory Syndrome / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D019316:Porcine respiratory and reproductive syndrome virus / Q000276:immunology* / Q000302:isolation & purification / Q000472:pathogenicity; D034421:Sus scrofa; D013552:Swine; D014611:Vaccination / Q000662:veterinary; D014613:Vaccines, Attenuated / Q000008:administration & dosage; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*; D014766:Viremia / Q000517:prevention & control
chemical_list: D000914:Antibodies, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines
keywords: Commercial PRRSV vaccines; NADC30-like PRRSV; Vaccine efficacy