title: Reply.
authors.affiliation: Clinical and Translational Science, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
authors.forename: Miguel D
authors.initials: MD
authors.lastname: Regueiro
authors.affiliation: University of Western Ontario, CEO Robarts Clinical Trials, London, Ontario, Canada.
authors.forename: Brian G
authors.initials: BG
authors.lastname: Feagan