title: Neurophysiologic studies of functional neurologic disorders.
abstract: Functional neurologic disorders are largely genuine and represent conversion disorders, where the dysfunction is unconscious, but there are some that are factitious, where the abnormality is feigned and conscious. Malingering, which can have the same manifestations, is similarly feigned, but not considered a genuine disease. There are no good methods for differentiating these three entities at the present time. Physiologic studies of functional weakness and sensory loss reveal normal functioning of primary motor and sensory cortex, but abnormalities of premotor cortex and association cortices. This suggests a top-down influence creating the dysfunction. Studies of functional tremor and myoclonus show that these disorders utilize normal voluntary motor structures to produce the involuntary movements, again suggesting a higher-level abnormality. Agency is abnormal and studies shows that dysfunction of the temporoparietal junction may be a correlate. The limbic system is overactive and might initiate involuntary movements, but the mechanism for this is not known. The limbic system would then be the source of top-down dysfunction. It can be speculated that the involuntary movements are involuntary due to lack of proper feedforward signaling.
authors.affiliation: Human Motor Control Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
authors.forename: M
authors.initials: M
authors.lastname: Hallett
mesh_terms: D003291:Conversion Disorder / Q000175:diagnosis*; D005162:Factitious Disorders / Q000175:diagnosis*; D006801:Humans; D008306:Malingering / Q000175:diagnosis*; D009422:Nervous System Diseases / Q000175:diagnosis* / Q000523:psychology*; D009482:Neurophysiology / Q000379:methods*
keywords: agency; limbic system; movement disorder; psychogenic; sensory loss; top-down; weakness