title: Th17 Cells Exhibit Antitumor Effects in MDS Possibly through Augmenting Functions of CD8+ T Cells.
abstract: Th17 cells are a newly found subset of distinct CD4+ Th effector cells' family and are found to play an important role in cancers. Myelodysplastic syndromes (MDS) are a common malignant hematological disease. Here, we showed that both the percentage and the function of Th17 cells were elevated in low-risk MDS while being decreased in high-risk MDS. Levels of upstream molecules of Th17 cells, IL-6 and IL-23, were higher in low-risk MDS but lower in high-risk MDS patients. The abnormal percentage of Th17 cells was closely related to clinical parameters including karyotype, morphologic blast percentage of bone marrow, peripheral absolute neutrophil count, and hemoglobin concentration. Furthermore, expression rates of perforin and granzyme B in BM CD3+CD8+ cells (cytotoxic T lymphocyte, CTL) positively correlated with levels of IL-17 but negatively correlated with BM blast percentage and could be significantly increased after stimulation with human recombinant IL-17 (rhIL-17). Our results suggested that Th17 cells might play an antitumor effect in the pathogenesis of MDS through IL-17/CTL pathway.
authors.affiliation: Department of Hematology, The General Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Jing
authors.identifier: 0000-0001-9718-7278
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Hematology, The General Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Lanzhu
authors.identifier: 0000-0002-8578-7564
authors.initials: L
authors.lastname: Yue
authors.affiliation: Department of Hematology, The General Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Huaquan
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Hematology, The General Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Hematology, The General Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Hui
authors.identifier: 0000-0002-1969-6015
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Hematology, The General Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Jinglian
authors.initials: J
authors.lastname: Tao
authors.affiliation: Department of Hematology, The General Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Qi
authors.affiliation: Department of Hematology, The General Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Yihao
authors.identifier: 0000-0002-6548-6270
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Hematology, The General Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Wei
authors.identifier: 0000-0002-1246-2195
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Hematology, The General Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Rong
authors.identifier: 0000-0003-2387-7123
authors.initials: R
authors.lastname: Fu
authors.affiliation: Department of Hematology, The General Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Zonghong
authors.identifier: 0000-0001-9802-9351
authors.initials: Z
authors.lastname: Shao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D002869:Chromosome Aberrations; D016207:Cytokines / Q000097:blood / Q000235:genetics / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D006801:Humans; D007958:Leukocyte Count; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000175:diagnosis / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D010641:Phenotype; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000378:metabolism; D058504:Th17 Cells / Q000276:immunology* / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D055815:Young Adult
chemical_list: D015415:Biomarkers; D016207:Cytokines; D014157:Transcription Factors