title: Gamma Knife Surgery for Recurrent or Residual Supratentorial Primitive Neuroectodermal Tumors.
abstract: Supratentorial primitive neuroectodermal tumors (PNETs) are highly malignant and rare tumors of the central nervous system.
  
  
  
  The aim of this study was to determine the role of Gamma Knife surgery (GKS) as a salvage treatment option for patients with recurrent or residual supratentorial PNETs.
  
  
  
  Between 1998 and 2014, 11 patients with supratentorial PNETs were retrospectively analyzed. This series consisted of 7 male and 4 female patients. The median age was 17 years. All patients received surgical resection followed by adjuvant therapy. The median time from operation to the first GKS treatment was 72.5 months. The median tumor volume was 17.5 cm3, and the median marginal dose was 11.5 Gy.
  
  
  
  15 (65%) of the 23 tumors had been controlled. The actuarial local tumor control rate was 91% at 3 months, 73% at 6 months, and 44% at 12 months. At the time of analysis, 9 (82%) of the patients had died. The median survival time after the first GKS session was 17 months. The median survival time from the initial diagnosis was 65 months. No adverse radiation effect after GKS treatment occurred in any patient.
  
  
  
  GKS treatment might be an effective salvage treatment option for recurrent or residual supratentorial PNETs after multimodal treatment.
authors.affiliation: Department of Neurosurgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
authors.forename: Young-Bem
authors.initials: YB
authors.lastname: Se
authors.forename: Dong Gyu
authors.initials: DG
authors.lastname: Kim
authors.forename: Sung Kwon
authors.initials: SK
authors.lastname: Kim
authors.forename: Jin Wook
authors.initials: JW
authors.lastname: Kim
authors.forename: Yong Hwy
authors.initials: YH
authors.lastname: Kim
authors.forename: Chul-Kee
authors.initials: CK
authors.lastname: Park
authors.forename: Hyun-Tai
authors.initials: HT
authors.lastname: Chung
authors.forename: Sun-Ha
authors.initials: SH
authors.lastname: Paek
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy* / Q000601:surgery; D018365:Neoplasm, Residual / Q000532:radiotherapy* / Q000601:surgery; D018242:Neuroectodermal Tumors, Primitive / Q000532:radiotherapy* / Q000601:surgery; D019635:Neurosurgical Procedures; D016634:Radiosurgery; D012189:Retrospective Studies; D016879:Salvage Therapy; D015173:Supratentorial Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D055815:Young Adult