title: Synthesis of pyrazolo[1,5-a]quinoxalin-4(5H)-ones via one-pot amidation/N-arylation reactions under transition metal-free conditions.
abstract: An efficient one-pot transition metal-free procedure for the synthesis of new pyrazolo[1,5-a]quinoxalin-4(5H)-ones from easily prepared 1-(2-chlorophenyl-5-ethylcarboxylate)pyrazoles and various primary alkylamines is described. The key steps involved in the synthesis of the new 5,6-fused ring system are the formation of an amide intermediate followed by an intramolecular N-arylation reaction via nucleophilic aromatic substitution.
authors.affiliation: Departamento de Química, Universidade Federal de Santa Maria, 97105-900 Santa Maria, Brazil. helio.bonacorso@ufsm.br.
authors.forename: Carson
authors.initials: C
authors.lastname: Wiethan
authors.affiliation: Departamento de Química, Universidade Federal de Santa Maria, 97105-900 Santa Maria, Brazil. helio.bonacorso@ufsm.br.
authors.forename: Steffany Z
authors.initials: SZ
authors.lastname: Franceschini
authors.affiliation: Departamento de Química, Universidade Federal de Santa Maria, 97105-900 Santa Maria, Brazil. helio.bonacorso@ufsm.br.
authors.forename: Helio G
authors.initials: HG
authors.lastname: Bonacorso
authors.affiliation: Department of Chemistry, Dalhousie University, Halifax, NS, B3H 4R2 Canada. mark.stradiotto@dal.ca.
authors.forename: Mark
authors.initials: M
authors.lastname: Stradiotto