title: Association between ATG16L1 gene polymorphism and the risk of Crohn's disease.
abstract: Objective To perform a meta-analysis to evaluate studies investigating the association between ATG16L1 gene polymorphism and Crohn's disease. Methods PubMed, Embase and Web of Science databases were searched for all studies focusing on the association of ATG16L1 and Crohn's disease. Combined odds ratios with 95% confidence intervals were calculated for four genetic models (allelic model: G allele versus A allele; additive model: GG versus AA; dominant model: GA + GG versus AA; recessive model: GG versus GA + AA) using either a random effects or fixed effects model. Results A total of 47 case-control studies involving 18 638 cases and 30 181 controls were included in the final meta-analysis. There was a significant association between ATG16L1 and Crohn's disease for all four genetic models. Significant associations were also shown in subgroup analyses when stratified by study design (population- or hospital-based). Conclusion In this meta-analysis, the ATG16L1 genotype was significantly associated with the risk of developing Crohn's disease.
authors.affiliation: 1 Department of Medical Affairs, General Hospital of PLA Chengdu Military Area Command, Chengdu, China.
authors.forename: Bei-Bei
authors.initials: BB
authors.lastname: Zhang
authors.affiliation: 2 Department of Thoracic Surgery, General Hospital of PLA Chengdu Military Area Command, Chengdu, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Liang
authors.affiliation: 1 Department of Medical Affairs, General Hospital of PLA Chengdu Military Area Command, Chengdu, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.affiliation: 1 Department of Medical Affairs, General Hospital of PLA Chengdu Military Area Command, Chengdu, China.
authors.forename: Ying-Jun
authors.initials: YJ
authors.lastname: Tan
mesh_terms: D000483:Alleles; D000071183:Autophagy-Related Proteins / Q000235:genetics*; D003424:Crohn Disease / Q000235:genetics*; D056726:Genetic Association Studies; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D006801:Humans; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors
chemical_list: C518959:ATG16L1 protein, human; D000071183:Autophagy-Related Proteins
keywords: ATG16L1; Crohn’s disease; autophagy; meta-analysis