title: A hydrogel-based glucose affinity microsensor.
abstract: We present a hydrogel-based affinity microsensor for continuous glucose measurements. The microsensor is based on microelectromechanical systems (MEMS) technology, and incorporates a synthetic hydrogel that is attached to the device surface viain situpolymerization. Glucose molecules that diffuses into and out of the device binds reversibly with boronic acid groups in the hydrogel via affinity binding, and causes changes in the dielectric properties of the hydrogel, which can be measured using a MEMS capacitive transducer to determine the glucose concentration. The use of thein situpolymerized hydrogel eliminates mechanical moving parts found in other types of affinity microsensors, as well as mechanical barriers such as semipermeable membranes that are otherwise required to hold the glucose-sensitive material. This facilitates the miniaturization and robust operation of the microsensor, and can potentially improve the tolerance of the device, when implanted subcutaneously, to biofouling. Experimental results demonstrate that in a glucose concentration range of 0-500 mg/dL and with a resolution of 0.35 mg/dL or better, the microsensor exhibits a repeatable and reversible response, and can potentially be useful for continuous glucose monitoring in diabetes care.
authors.affiliation: Department of Mechanical Engineering, Columbia University, New York, NY, USA.
authors.forename: Junyi
authors.initials: J
authors.lastname: Shang
authors.affiliation: Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Yan
authors.affiliation: Department of Mechanical Engineering, Columbia University, New York, NY, USA.
authors.forename: Zhixing
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Mechanical Engineering, Columbia University, New York, NY, USA.
authors.forename: Xian
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC, USA.
authors.forename: Panita
authors.initials: P
authors.lastname: Maturavongsadit
authors.affiliation: Department of Mechanical Engineering, Columbia University, New York, NY, USA.
authors.forename: Bing
authors.initials: B
authors.lastname: Song
authors.affiliation: Department of Mechanical Engineering, Columbia University, New York, NY, USA.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Jia
authors.affiliation: Department of Mechanical Engineering, Columbia University, New York, NY, USA.
authors.forename: Tieying
authors.initials: T
authors.lastname: Ma
authors.affiliation: College of Precision Instrument and Opto-electronics Engineering, Tianjin University, Tianjin, China.
authors.forename: Dachao
authors.initials: D
authors.lastname: Li
authors.affiliation: College of Precision Instrument and Opto-electronics Engineering, Tianjin University, Tianjin, China.
authors.forename: Kexin
authors.initials: K
authors.lastname: Xu
authors.affiliation: Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC, USA.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Mechanical Engineering, Columbia University, New York, NY, USA.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Lin
keywords: affinity sensor; continuous glucose monitoring; hydrogel