title: Comparative Pharmacokinetic Profiling of Different Polymyxin B Components.
abstract: Polymyxin B is increasingly used as a treatment of last resort for multidrug-resistant Gram-negative infections. Despite being available as a mixture of several structurally related analogues, the properties are commonly reported as an aggregate of the individual components. We compared the pharmacokinetics of individual polymyxin B components in an animal model and in humans. There were no considerable differences observed in the pharmacokinetics among major components of polymyxin B. Combining different components for pharmacokinetic analysis appeared reasonable.
authors.affiliation: Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, Texas, USA.
authors.forename: Pooja
authors.initials: P
authors.lastname: Manchandani
authors.affiliation: Department of Pharmacy, New York University Langone Medical Center, New York, New York, USA.
authors.forename: Yanina
authors.initials: Y
authors.lastname: Dubrovskaya
authors.affiliation: Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, Texas, USA.
authors.forename: Song
authors.initials: S
authors.lastname: Gao
authors.affiliation: Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, Texas, USA vtam@uh.edu.|Department of Pharmacy Practice and Translational Research, University of Houston College of Pharmacy, Houston, Texas, USA.
authors.forename: Vincent H
authors.initials: VH
authors.lastname: Tam
mesh_terms: D000368:Aged; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000493:pharmacokinetics*; D019540:Area Under Curve; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011112:Polymyxin B / Q000737:chemistry / Q000493:pharmacokinetics*; D017207:Rats, Sprague-Dawley
chemical_list: D000900:Anti-Bacterial Agents; D011112:Polymyxin B