title: Synthesis and Functionalization of Porphyrins through Organometallic Methodologies.
abstract: This review focuses on the postfunctionalization of porphyrins and related compounds through catalytic and stoichiometric organometallic methodologies. The employment of organometallic reactions has become common in porphyrin synthesis. Palladium-catalyzed cross-coupling reactions are now standard techniques for constructing carbon-carbon bonds in porphyrin synthesis. In addition, iridium- or palladium-catalyzed direct C-H functionalization of porphyrins is emerging as an efficient way to install various substituents onto porphyrins. Furthermore, the copper-mediated Huisgen cycloaddition reaction has become a frequent strategy to incorporate porphyrin units into functional molecules. The use of these organometallic techniques, along with the traditional porphyrin synthesis, now allows chemists to construct a wide range of highly elaborated and complex porphyrin architectures.
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Nagoya University , Nagoya 464-8603, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Hiroto
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Nagoya University , Nagoya 464-8603, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Miyake
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Nagoya University , Nagoya 464-8603, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shinokubo
mesh_terms: D002384:Catalysis; D006219:Halogens / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry*; D011166:Porphyrins / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D006219:Halogens; D009942:Organometallic Compounds; D011166:Porphyrins