title: Both high expression of nucleophosmin/B23 and CRM1 predicts poorer prognosis in human gastric cancer.
abstract: Nucleophosmin/B23 and CRM1 are molecular markers which play an important role in tumorigenesis and tumor progression in gastric cancer (GC). However, the association between the two remains unclear. This study evaluated the expression and the correlation of B23 and CRM1 in GC. B23 and CRM1 expression in GC and adjacent noncancerous tissues (ANCT) of gastrectomy specimens from 131 GC patients was measured by immunohistochemistry. Positive expression rates of B23 and CRM1 were significantly higher in GC tissues than in ANCT. The high expression rates of B23 and CRM1 were significantly higher in patients with more advanced tumor stages and distant metastasis (all p < 0.05). Only high expression of CRM1was correlated with positive Her2 status (p = 0.01). B23 expression was positively correlated with CRM1expression in GC tissues (p = 0.038). Univariate analysis showed that TNM stage (p = 0.0001), metastasis (p = 0.027), B23 (p = 0.0111), and CRM1 expression (p = 0.0019) were significant risk factors affecting overall survival. Both high expression of B23 and CRM1 in GC patients suggests poor prognosis, co-expression of the two (p = 0.043) even worse. Cox multivariate analysis showed that positive B23 (p = 0.0231) and CRM1 (p = 0.0048) expression were both independent prognostic factors that negatively correlated with survival. We revealed the co-expression of B23 or CRM1 in GC. The expression levels of B23 or CRM1 were closely related to poor prognosis in GC, and both B23 or CRM1 were independent risk factor.
authors.affiliation: Department of Radiotherapy, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Zhou
authors.affiliation: Department of Radiotherapy, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
authors.forename: Ercheng
authors.initials: E
authors.lastname: Chen
authors.affiliation: Department of Radiotherapy, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
authors.forename: Dong
authors.initials: D
authors.lastname: You
authors.affiliation: Department of Radiotherapy, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
authors.forename: Yipeng
authors.initials: Y
authors.lastname: Song
authors.affiliation: Department of Oncology, Qingdao Municipal Hospital, School of Medical, Qingdao University, Qingdao, China.
authors.forename: Zhenni
authors.initials: Z
authors.lastname: Sun
authors.affiliation: Department of Oncology, Qingdao Municipal Hospital, School of Medical, Qingdao University, Qingdao, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Yue
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D028884:Karyopherins / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000032:analysis*; D000090243:Nucleophosmin; D011379:Prognosis; D018160:Receptors, Cytoplasmic and Nuclear / Q000032:analysis*; D012307:Risk Factors; D013270:Stomach / Q000473:pathology*; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D016019:Survival Analysis; D000097606:Exportin 1 Protein
chemical_list: D014408:Biomarkers, Tumor; D028884:Karyopherins; D009687:Nuclear Proteins; D000090243:Nucleophosmin; D018160:Receptors, Cytoplasmic and Nuclear; D000097606:Exportin 1 Protein; C000716967:NPM1 protein, human
keywords: CRM1; Nucleophosmin/B23; gastric cancer