title: Human immunodeficiency virus associated thrombotic thrombocytopenic purpura, a clinical conundrum.
abstract: HIV complicates the diagnostic and therapeutic approaches to idiopathic thrombotic thrombocytopenic purpura (TTP), prompting debate in the literature regarding the benefit of plasma exchange versus simple plasma infusion. Herein we present a case of HIV-TTP, initially treated conservatively with plasma infusion but because of progressive neurologic decline, required urgent plasma exchange for resolution of hematologic derangements and neurologic sequelae. Based on the available literature, there appears to be a spectrum of HIV-associated TTP disorders. Patients with advanced HIV disease and opportunistic infections who present with thrombotic microangiopathy tend to respond to simple plasma infusion, while patients with less progressive HIV disease tend to behave like those with idiopathic TTP, requiring plasma exchange rather than simple plasma infusion. This article illustrates that in patients with HIV-TTP who do not respond to plasma infusion, early escalation to plasma exchange may help avoid life-threatening complications such as seizures and even death.
authors.affiliation: Department of Internal Medicine, Virginia Commonwealth University, 5017 Caledonia Rd, Richmond, Virginia, 23225.
authors.forename: Nathaniel C
authors.initials: NC
authors.lastname: Warner
authors.affiliation: Division of Infectious Diseases, Virginia Commonwealth University, Richmond, Virginia.
authors.forename: Leroy B
authors.initials: LB
authors.lastname: Vaughan
authors.affiliation: Division of Infectious Diseases, Virginia Commonwealth University, Richmond, Virginia.
authors.forename: Richard P
authors.initials: RP
authors.lastname: Wenzel
mesh_terms: D000328:Adult; D005260:Female; D015658:HIV Infections; D006801:Humans; D010949:Plasma; D010951:Plasma Exchange / Q000379:methods*; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications / Q000628:therapy* / Q000821:virology*
keywords: HIV; HIV-TMA; HIV-TTP; plasma exchange (PEX); thrombotic microangiopathy (TMA); thrombotic thrombocytopenic purpura (TTP)