title: High carbohydrate diet induces nonalcoholic steato-hepatitis (NASH) in a desert gerbil.
abstract: A high intake of sugars has been linked to diet-induced health problems. The aim of this study was to assess whether the long-term consumption of a high-carbohydrate diet (HCD) would cause the hepatic histopathological and metabolic abnormalities that characterize nonalcoholic steatohepatitis (NASH) in a desert gerbil, Gerbillus gerbillus. Compared to natural diet, HCD leads to several metabolic disorders including adiposity, dyslipidemia, insulin resistance, ectopic fat deposition in the liver, which were associated with higher levels of transcripts of genes involved with fat synthesis, endoplasmic reticulum (ER) stress, and fibrosis. In the same way, the experimented animals showed enhanced oxidative stress. Taken together, these results demonstrate that HCD consumption in gerbils induces metabolic disorders and damaged liver, which are key contributors to NASH development. These results suggest that this rodent represents a valuable natural model for human diet-induced metabolic disorders and nonalcoholic fatty liver disease (NAFLD).
authors.affiliation: LBPO/Nutrition-métabolisme, FSB/USTHB, BP 32, El Alia, 16111 Alger, Algeria. Electronic address: semianenesrine@yahoo.fr.
authors.forename: Nesrine
authors.initials: N
authors.lastname: Semiane
authors.affiliation: INSERM, UMR-S 872, centre de recherches des Cordeliers, 75006 Paris, France; Université Paris-6-Pierre-et-Marie-Curie, UMR S 872, 75006 Paris, France; Université Paris-Descartes, UMR S 872, 75006 Paris, France.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Foufelle
authors.affiliation: INSERM, UMR-S 872, centre de recherches des Cordeliers, 75006 Paris, France; Université Paris-6-Pierre-et-Marie-Curie, UMR S 872, 75006 Paris, France; Université Paris-Descartes, UMR S 872, 75006 Paris, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Ferré
authors.affiliation: INSERM, UMR-S 872, centre de recherches des Cordeliers, 75006 Paris, France; Université Paris-6-Pierre-et-Marie-Curie, UMR S 872, 75006 Paris, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Hainault
authors.affiliation: Laboratoire de biologie et environnement, université Mentouri, route de Ain El Bey, 25000 Constantine, Algeria.
authors.forename: Souad
authors.initials: S
authors.lastname: Ameddah
authors.affiliation: LBPO/Nutrition-métabolisme, FSB/USTHB, BP 32, El Alia, 16111 Alger, Algeria.
authors.forename: Aicha
authors.initials: A
authors.lastname: Mallek
authors.affiliation: LBPO/Nutrition-métabolisme, FSB/USTHB, BP 32, El Alia, 16111 Alger, Algeria.
authors.forename: Ali
authors.initials: A
authors.lastname: Khalkhal
authors.affiliation: LBPO/Nutrition-métabolisme, FSB/USTHB, BP 32, El Alia, 16111 Alger, Algeria.
authors.forename: Yasmina
authors.initials: Y
authors.lastname: Dahmani
mesh_terms: D050154:Adiposity / Q000187:drug effects; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D004040:Dietary Carbohydrates / Q000633:toxicity*; D050171:Dyslipidemias / Q000097:blood / Q000139:chemically induced; D059865:Endoplasmic Reticulum Stress / Q000187:drug effects; D005260:Female; D005849:Gerbillinae / Q000502:physiology*; D007333:Insulin Resistance; D015227:Lipid Peroxidation / Q000187:drug effects; D050155:Lipogenesis / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease / Q000139:chemically induced* / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D018384:Oxidative Stress
chemical_list: D004040:Dietary Carbohydrates
keywords: E.R. stress; Gerbillus gerbillus; Insulin resistance; Insulino-résistance; Lipogenesis; Lipogenèse; Oxidative stress; Stress R.E.; Stress oxydatif