title: Activation of p38-mitogen-activated protein kinase contributes to ischemia reperfusion in rat brain.
abstract: Inflammation plays an important role in cerebral ischemia reperfusion, which can cause severe damage to the brain and may lead to cerebral hemorrhage transformation. p38-mitogen-activated protein kinase (p38mapk) has been implicated in the etiology of a number of diseases because it is a cause of inflammation, but comparatively little research has been carried out into its role in the etiology of ischemia reperfusion. We investigated the expression of p38mapk in cerebral ischemia reperfusion to gain a better understanding of its potential role in hemorrhagic transformation (HT). One hundred rats were randomly divided into three groups: an ischemia reperfusion group, an ischemia group, and a sham-operated group. We carried out neurological deficit assessments, infarct volume measurements, histopathological examinations, and immunohistochemistry analyses. p38mapk was overexpressed in the ischemia reperfusion group, which exhibited severe tissue damage and greater edema than the other two groups. These results suggest that p38mapk plays an important role in cerebral ischemia reperfusion, and may be one of the causes of HT.
authors.affiliation: Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Song
authors.affiliation: Department of Internal Medicine, Qingdao Central Hospital, Qingdao, Shandong, China honglizoucn@126.com.
authors.forename: H L
authors.initials: HL
authors.lastname: Zou
authors.affiliation: Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Zhao
authors.affiliation: Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
authors.forename: L Q
authors.initials: LQ
authors.lastname: Yu
authors.affiliation: Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
authors.forename: Z X
authors.initials: ZX
authors.lastname: Tan
authors.affiliation: Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
authors.forename: R
authors.initials: R
authors.lastname: Kong
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D002545:Brain Ischemia / Q000201:enzymology* / Q000503:physiopathology / Q000601:surgery; D002452:Cell Count; D004789:Enzyme Activation; D008297:Male; D009336:Necrosis; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000201:enzymology* / Q000503:physiopathology / Q000601:surgery; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism*
chemical_list: D048051:p38 Mitogen-Activated Protein Kinases