title: Lipid - Motor Interactions: Soap Opera or Symphony?
abstract: Intracellular transport of organelles can be driven by multiple motor proteins that bind to the lipid membrane of the organelle and work as a team. We review present knowledge on how lipids orchestrate the recruitment of motors to a membrane. Looking beyond recruitment, we also discuss how heterogeneity and local mechanical properties of the membrane may influence function of motor-teams. These issues gain importance because phagocytosed pathogens use lipid-centric strategies to manipulate motors and survive in host cells.
authors.affiliation: Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Colaba, Mumbai 400 005, India.
authors.forename: Divya
authors.initials: D
authors.lastname: Pathak
authors.affiliation: Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Colaba, Mumbai 400 005, India. Electronic address: roop@tifr.res.in.
authors.forename: Roop
authors.initials: R
authors.lastname: Mallik
mesh_terms: D000818:Animals; D001692:Biological Transport; D001696:Biomechanical Phenomena; D002462:Cell Membrane / Q000378:metabolism*; D006801:Humans; D008563:Membrane Lipids / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism; D020409:Molecular Motor Proteins / Q000378:metabolism*; D015388:Organelles / Q000378:metabolism*
chemical_list: D008563:Membrane Lipids; D020409:Molecular Motor Proteins