title: MLL translocation in two castration-resistant prostate cancer patients.
abstract: The mixed-lineage leukemia (MLL) protein acts as a histone methyltransferase regulating multiple genetic elements. Rearrangements of the MLL gene result in expression of MLL-fusion proteins that occur in some acute leukemias and are associated with poor prognosis. The MLL protein complex has been shown to interact with the androgen receptor via the MLL-menin subunit, thus promoting gene activation. The presence of MLL translocation has not been previously reported in patients with castrate resistant prostate cancer (CRPC). We describe two cases of metastatic CRPC with a translocation in the MLL gene detected by a specific fluorescent in situ hybridization (FISH) assay. Both patients had an aggressive course and succumbed to the illness.
authors.affiliation: Section of Hematology/Medical Oncology, Tulane University Hematology/Oncology. New Orleans, Louisiana, USA.
authors.forename: Rajasree Pia
authors.initials: RP
authors.lastname: Chowdry
authors.forename: Elisa
authors.initials: E
authors.lastname: Ledet
authors.forename: Lahiru
authors.initials: L
authors.lastname: Ranasinghe
authors.forename: Alton Oliver
authors.initials: AO
authors.lastname: Sartor
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects; D019468:Disease Management; D018450:Disease Progression; D006801:Humans; D008297:Male; D008875:Middle Aged; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics*; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D011467:Prostate / Q000000981:diagnostic imaging / Q000473:pathology; D064129:Prostatic Neoplasms, Castration-Resistant / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D014178:Translocation, Genetic; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D051788:Myeloid-Lymphoid Leukemia Protein