title: Twelve-Month Follow-Up of Dexamethasone Implants for Macular Edema from Various Diseases in Vitrectomized and Nonvitrectomized Eyes.
abstract: Purpose. To evaluate the best-corrected visual acuity (BCVA), central retinal thickness (CRT), and the number of dexamethasone implants needed to treat cystoid macular edema (CME) from various etiologies over 12 months in vitrectomized and nonvitrectomized eyes.Methods. This multicenter retrospective cohort study included 112 patients with CME secondary to retinal diseases treated pro re nata (PRN) with a 0.7 mg intravitreal dexamethasone implant for 12 months. The BCVA, CRT, adverse events, safety data, and number of implants were recorded.Results. Vitrectomized and nonvitrectomized eyes received means of three implants and one implant, respectively, over 12 months (P< 0.001). The mean BCVA of all patients improved from 0.13 at baseline to 0.33 (P< 0.001) 12 months after one (P= 0.001), two (P= 0.041), and three (P< 0.001) implants but not four implants (P= 0.068). The mean baseline CRT decreased significantly (P< 0.001) from 463 to 254 microns after 12 months with one (P< 0.001), two (P= 0.002), and three (P= 0.001) implants but not with four implants (P= 0.114). The anatomic and functional outcomes were not significantly different between vitrectomized and nonvitrectomized eyes. Increased IOP was the most common adverse event (23.2%).Conclusions. Dexamethasone implant administered PRN improved VA and decreased CRT in CME, with possible long-term clinically relevant benefits for treating CME from various etiologies. Vitrectomized eyes needed more implants compared with nonvitrectomized eyes.
authors.affiliation: Department of Ophthalmology, Federal University of São Paulo, São Paulo, SP, Brazil.
authors.forename: Eduardo A
authors.identifier: 0000-0001-6790-4627
authors.initials: EA
authors.lastname: Novais
authors.affiliation: Department of Ophthalmology, Federal University of São Paulo, São Paulo, SP, Brazil; Brazilian Institute of Fighting Against Blindness (INBRACE), Assis/Presidente Prudente, SP, Brazil.
authors.forename: Mauricio
authors.identifier: 0000-0002-7034-8091
authors.initials: M
authors.lastname: Maia
authors.affiliation: Department of Ophthalmology, Federal University of São Paulo, São Paulo, SP, Brazil.
authors.forename: Paulo Augusto de Arruda Mello
authors.initials: PA
authors.lastname: Filho
authors.affiliation: Department of Ophthalmology, Federal University of São Paulo, São Paulo, SP, Brazil.
authors.forename: João Rafael de Oliveira
authors.initials: JR
authors.lastname: Dias
authors.affiliation: Federal University of Goiás, Goiânia, GO, Brazil.
authors.forename: José Maurício B B
authors.identifier: 0000-0002-9799-5360
authors.initials: JM
authors.lastname: Garcia
authors.affiliation: Department of Ophthalmology, Federal University of São Paulo, São Paulo, SP, Brazil.
authors.forename: Gabriel C
authors.initials: GC
authors.lastname: de Andrade
authors.affiliation: Federal University of Goiás, Goiânia, GO, Brazil.
authors.forename: Ricardo N
authors.initials: RN
authors.lastname: Louzada
authors.affiliation: Federal University of Goiás, Goiânia, GO, Brazil.
authors.forename: Marcos
authors.initials: M
authors.lastname: Ávila
authors.affiliation: Department of Ophthalmology, Federal University of São Paulo, São Paulo, SP, Brazil.
authors.forename: André
authors.identifier: 0000-0003-3776-7195
authors.initials: A
authors.lastname: Maia
authors.affiliation: Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: J Fernando
authors.identifier: 0000-0001-6104-5737
authors.initials: JF
authors.lastname: Arevalo
authors.affiliation: Asociados de Macula Vitreo y Retina de Costa Rica, San Jose, Costa Rica.
authors.forename: Lihteh
authors.identifier: 0000-0002-3387-7058
authors.initials: L
authors.lastname: Wu
authors.affiliation: University of Puerto Rico, San Juan, PR, USA.
authors.forename: Maria
authors.initials: M
authors.lastname: Berrocal
authors.affiliation: Department of Ophthalmology, Federal University of São Paulo, São Paulo, SP, Brazil.
authors.forename: Emmerson
authors.identifier: 0000-0001-8813-3972
authors.initials: E
authors.lastname: Badaró
authors.affiliation: Department of Ophthalmology, Federal University of São Paulo, São Paulo, SP, Brazil.
authors.forename: Michel
authors.initials: M
authors.lastname: Farah