title: Non-Steroidal Anti-Inflammatory Drugs: An Overview of Cardiovascular Risks.
abstract: While aspirin may offer protection, other non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) can cause serious cardiovascular side effects and complications. This has led to a general "black box" warning for cardiovascular adverse events for NSAIDs. This review explores the different mechanisms underlying the protective effects of aspirin, the NSAID associated renovascular effects causing hypertension, edema and heart failure, the cardiovascular effects causing myocardial infarction and stroke, and the possible deleterious interaction between NSAIDs and aspirin.
authors.affiliation: Department of Rheumatology and Clinical Immunology, Medisch Spectrum Twente and University of Twente, Ariensplein 1, 7500 KA Enschede, The Netherlands. i.meek@mst.nl.
authors.forename: Inger L
authors.initials: IL
authors.lastname: Meek
authors.affiliation: Department of Rheumatology and Clinical Immunology, Medisch Spectrum Twente and University of Twente, Ariensplein 1, 7500 KA Enschede, The Netherlands. m.vandelaar@mst.nl.
authors.forename: Mart A F J
authors.initials: MA
authors.lastname: Van de Laar
authors.affiliation: Department of Rheumatology and Clinical Immunology, Medisch Spectrum Twente and University of Twente, Ariensplein 1, 7500 KA Enschede, The Netherlands. h.vonkeman@mst.nl.
authors.forename: Harald
authors.initials: H
authors.lastname: E Vonkeman
keywords: NSAIDs; aspirin; cardiovascular events