title: Total synthesis of wewakazole B.
abstract: Wewakazole B is a novel cyclodecapeptide with highly potent cytotoxic activity isolated from a sample of M. producens collected from the Red Sea. It contains nine common and three modified amino acid residues. The first total synthesis of Wewakazole B was successfully achieved on a gram scale, unambiguously confirming its structure. Notable features include the careful choice of amino acid-protecting groups and the construction of three different substituted oxazoles present in this natural product.
authors.affiliation: The Fourth People's Hospital of Shenzhen, Shenzhen 518033, China. bhlong121@163.com and Shenzhen Institute of Geriatrics, Shenzhen 518020, China and The Second People's Hospital of Shenzhen, Shenzhen 518035, China.
authors.forename: Bohua
authors.initials: B
authors.lastname: Long
authors.affiliation: Key Lab for New Drug Research of TCM and Shenzhen Branch, State R&D Centre for Viro-Biotech, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, China.
authors.forename: Jingzhao
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Key Lab for New Drug Research of TCM and Shenzhen Branch, State R&D Centre for Viro-Biotech, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, China.
authors.forename: Xudong
authors.initials: X
authors.lastname: Tang
authors.affiliation: The Fourth People's Hospital of Shenzhen, Shenzhen 518033, China. bhlong121@163.com and Shenzhen Institute of Geriatrics, Shenzhen 518020, China and The Second People's Hospital of Shenzhen, Shenzhen 518035, China.
authors.forename: Zhengzhi
authors.initials: Z
authors.lastname: Wu
mesh_terms: D060326:Chemistry Techniques, Synthetic; D010080:Oxazoles / Q000737:chemistry; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D010080:Oxazoles; D010456:Peptides, Cyclic; C473357:wewakazole