title: Digit Tip Regeneration and Beyond: Schwann Cell Progenitors to the Rescue.
abstract: Digit tip regeneration following amputation is an innate response in some mammals, including mice. In this issue of Cell Stem Cell, Johnston et al. (2016) show that Schwann cell precursors are necessary for this process and can rescue regeneration in denervated digit tips through secretion of pro-regenerative factors including OSM and PDGF-AA.
authors.affiliation: Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: jlehoczky@partners.org.
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Lehoczky
mesh_terms: D000818:Animals; D005121:Extremities; D008322:Mammals; D051379:Mice; D012038:Regeneration; D012583:Schwann Cells; D013234:Stem Cells