title: Changes in Weight and Metabolic Syndrome Are Associated With Prostate Growth Rate Over a 5-Year Period.
abstract: OBJECTIVE
  To evaluate the relationship between changes in weight, waist circumference (WC), metabolic syndrome (MetS), and prostate growth over 5 years in the adult population.
  
  
  METHODS
  Data were collected from 1088 adult men (age ≥40 years) without history of prostate cancer who underwent more than 2 general health screenings between 2006 and 2013. Percent changes in prostate volume (PV) were assessed for 5 years after baseline measurements. Associations between prostate growth and change in weight, WC and MetS status, respectively, were calculated using uni- and multivariate linear regression analyses.
  
  
  RESULTS
  During the 5 years, the median PV changes were 1.3 cc/year corresponding to a median growth rate of 6.2%/year. By multivariate linear regression analysis, change in weight was significantly associated with prostate growth (P < .01) after adjusting for age, initial PV, and initial body mass index (BMI). Prostate growth and weight changes were correlated in obese men (initial BMI ≥ 25 kg/m2) (0.150; 95% confidence interval [CI], 0.425-1.547; P <.01) but not in nonobese men (initial BMI < 25 kg/m2) (0.054; 95% CI, -0.176 to 0. 858; P = .20). Patients with newly developed MetS showed greater prostate growth than those who did not have MetS (6.796; 95% CI, 1.599-12.003; P = .01).
  
  
  CONCLUSIONS
  Changes in weight, WC and newly diagnosed MetS affected prostate growth rate during 5 years. Reducing weight and controlling MetS could decrease the prostate growth rate.
authors.affiliation: Department of Health Screening and Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
authors.forename: Yoon Soo
authors.initials: YS
authors.lastname: Kyung
authors.affiliation: Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
authors.forename: Dalsan
authors.initials: D
authors.lastname: You
authors.affiliation: Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
authors.forename: In Gab
authors.initials: IG
authors.lastname: Jeong
authors.affiliation: Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
authors.forename: Seungbong
authors.initials: S
authors.lastname: Han
authors.affiliation: Department of Health Screening and Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
authors.forename: Hong-Kyu
authors.initials: HK
authors.lastname: Kim
authors.affiliation: Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address: cskim@amc.seoul.kr.
authors.forename: Choung-Soo
authors.initials: CS
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods / Q000706:statistics & numerical data; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000453:epidemiology; D008875:Middle Aged; D009765:Obesity / Q000175:diagnosis / Q000453:epidemiology; D009929:Organ Size; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D013223:Statistics as Topic; D055105:Waist Circumference