title: Anti-allergic effects of His-Ala-Gln tripeptide in vitro and in vivo.
abstract: We examined the inhibitory effects of HAQ (His-Ala-Gln) peptide on type-1 allergy in vitro and in vivo. HAQ peptide inhibited β-hexosaminidase release and intracellular Ca2+levels of rat basophilic leukemia RBL-2H3 cells. Oral administration of a HAQ peptide-added diet (1 mg/mouse/administration) to C3H/HeJ mice for 14 days led to significant suppression of allergic symptoms, but did not reduce allergen-specific IgE or IgG1.
authors.affiliation: a Department of Nutrition , University of Kochi , Kochi , Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Tanaka
authors.affiliation: a Department of Nutrition , University of Kochi , Kochi , Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Watanabe
authors.affiliation: b Department of Physical Therapy , Seirei Christopher University , Hamamatsu , Japan.
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Yoshimoto
authors.affiliation: c College of Bioscience and Biotechnology , Chubu University , Kasugai , Japan.
authors.forename: Hana
authors.initials: H
authors.lastname: Kozai
authors.affiliation: d Faculty of Education , Ehime University , Matsuyama , Japan.
authors.forename: Takeaki
authors.initials: T
authors.lastname: Okamoto
mesh_terms: D000284:Administration, Oral; D000818:Animals; D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002118:Calcium / Q000378:metabolism; D045744:Cell Line, Tumor; D006967:Hypersensitivity / Q000097:blood / Q000188:drug therapy; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D042541:Intracellular Space / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D009842:Oligopeptides / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D001619:beta-N-Acetylhexosaminidases / Q000378:metabolism
chemical_list: D018926:Anti-Allergic Agents; D007074:Immunoglobulin G; D009842:Oligopeptides; C000613969:histidyl-alanyl-glutamine; D007073:Immunoglobulin E; D001619:beta-N-Acetylhexosaminidases; D002118:Calcium
keywords: RBL-2H3 cell; anti-allergic effect; mouse model; peptide