title: Synthesis and optimization of ceftriaxone-loaded solid lipid nanocarriers.
abstract: The use of nanocarriers to enhance drug delivery efficacy has been increasing in the healthcare field due to their tunable surface properties. In this study, ceftriaxone-loaded solid lipid nanoparticles (CL-SLNPs) were synthesized using a water-in-oil-in-water (w/o/w) type double emulsification method. The formulation was optimized using response surface methodology (RSM) and was characterized using transmission electron microscopy (TEM), photon correlation spectroscopy (PCS), and UV-vis and Fourier transform infrared (FTIR) spectroscopy. The CL-SLNPs were of spherical shape, 15-20nm in size, and retained the properties of the drug or other constituents/ingredients after loading. The prepared nanoformulation offered sustained drug release after 24h, while ceftriaxone sodium followed a burst release. Antibacterial activity of the nanoformulation was evaluated against different gram-positive and gram-negative bacterial strains. The minimum inhibitory concentration of CL-SLNPs against Pseudomonas aeruginosa was determined as 31μg/mL.
authors.affiliation: Department of Bio and Nano Technology, Guru Jambheshwar University of Science and Technology, Hisar, Haryana 125001, India. Electronic address: ksandeep36@yahoo.com.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Department of Bio and Nano Technology, Guru Jambheshwar University of Science and Technology, Hisar, Haryana 125001, India.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Bhanjana
authors.affiliation: Department of Bio and Nano Technology, Guru Jambheshwar University of Science and Technology, Hisar, Haryana 125001, India.
authors.forename: Arvind
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Department of Bio and Nano Technology, Guru Jambheshwar University of Science and Technology, Hisar, Haryana 125001, India.
authors.forename: Kapila
authors.initials: K
authors.lastname: Taneja
authors.affiliation: Department of Bio and Nano Technology, Guru Jambheshwar University of Science and Technology, Hisar, Haryana 125001, India.
authors.forename: Neeraj
authors.initials: N
authors.lastname: Dilbaghi
authors.affiliation: Department of Civil & Environmental Engineering, Hanyang University, 222 Wangsimni-Ro, Seoul 04763, Republic of Korea. Electronic address: kkim61@hanyang.ac.kr.
authors.forename: Ki-Hyun
authors.initials: KH
authors.lastname: Kim
mesh_terms: D002443:Ceftriaxone / Q000008:administration & dosage*; D004337:Drug Carriers / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D013499:Surface Properties
chemical_list: D004337:Drug Carriers; D008055:Lipids; D002443:Ceftriaxone
keywords: Antibacterial; Ceftriaxone sodium; Emulsification; Nanoformulation; Solid lipid nanoparticles