title: Chemotherapeutic drug-specific alteration of microvascular blood flow in murine breast cancer as measured by diffuse correlation spectroscopy.
abstract: The non-invasive,in vivomeasurement of microvascular blood flow has the potential to enhance breast cancer therapy monitoring. Here, longitudinal blood flow of 4T1 murine breast cancer (N=125) under chemotherapy was quantified with diffuse correlation spectroscopy based on layer models. Six different treatment regimens involving doxorubicin, cyclophosphamide, and paclitaxel at clinically relevant doses were investigated. Treatments with cyclophosphamide increased blood flow as early as 3 days after administration, whereas paclitaxel induced a transient blood flow decrease at 1 day after administration. Early blood flow changes correlated strongly with the treatment outcome and distinguished treated from untreated mice individually for effective treatments.
authors.affiliation: Department of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Ramirez
authors.affiliation: Department of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA.
authors.forename: Ashley R
authors.initials: AR
authors.lastname: Proctor
authors.affiliation: Department of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA.
authors.forename: Ki Won
authors.initials: KW
authors.lastname: Jung
authors.affiliation: Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14642, USA.
authors.forename: Tong Tong
authors.initials: TT
authors.lastname: Wu
authors.affiliation: The Institute of Optics, University of Rochester, Rochester, NY 14627, USA.
authors.forename: Songfeng
authors.initials: S
authors.lastname: Han
authors.affiliation: Department of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA.
authors.forename: Russell R
authors.initials: RR
authors.lastname: Adams
authors.affiliation: Department of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA.
authors.forename: Jingxuan
authors.initials: J
authors.lastname: Ren
authors.affiliation: Department of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA.
authors.forename: Daniel K
authors.initials: DK
authors.lastname: Byun
authors.affiliation: Department of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA.
authors.forename: Kelley S
authors.initials: KS
authors.lastname: Madden
authors.affiliation: Department of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA.
authors.forename: Edward B
authors.initials: EB
authors.lastname: Brown
authors.affiliation: Department of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA; The Institute of Optics, University of Rochester, Rochester, NY 14627, USA; Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY 14642, USA.
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Foster
authors.affiliation: ICFO- Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, 08860 Castelldefels (Barcelona), Spain.
authors.forename: Parisa
authors.initials: P
authors.lastname: Farzam
authors.affiliation: ICFO- Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, 08860 Castelldefels (Barcelona), Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08015 Barcelona, Spain.
authors.forename: Turgut
authors.initials: T
authors.lastname: Durduran
authors.affiliation: Department of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA; Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY 14627, USA.
authors.forename: Regine
authors.initials: R
authors.lastname: Choe
keywords: (170.3660) Light propagation in tissues; (170.6480) Spectroscopy, speckle; (290.4210) Multiple scattering