title: Ion beam induced18F-radiofluorination: straightforward synthesis of gaseous radiotracers for the assessment of regional lung ventilation using positron emission tomography.
abstract: A simple, straightforward and efficient method for the synthesis of [18F]CF4and [18F]SF6based on an ion beam-induced isotopic exchange reaction is presented. Positron emission tomography ventilation studies in rodents using [18F]CF4showed a uniform distribution of the radiofluorinated gas within the lungs and rapid elimination after discontinuation of the administration.
authors.affiliation: Molecular Imaging Unit, CIC biomaGUNE, Paseo Miramón 182, 20009 San Sebastián, Guipúzcoa, Spain. jllop@cicbiomagune.es.
authors.forename: V
authors.initials: V
authors.lastname: Gómez-Vallejo
authors.affiliation: Molecular Imaging Unit, CIC biomaGUNE, Paseo Miramón 182, 20009 San Sebastián, Guipúzcoa, Spain. jllop@cicbiomagune.es.
authors.forename: A
authors.initials: A
authors.lastname: Lekuona
authors.affiliation: Molecular Imaging Unit, CIC biomaGUNE, Paseo Miramón 182, 20009 San Sebastián, Guipúzcoa, Spain. jllop@cicbiomagune.es.
authors.forename: Z
authors.initials: Z
authors.lastname: Baz
authors.affiliation: Molecular Imaging Unit, CIC biomaGUNE, Paseo Miramón 182, 20009 San Sebastián, Guipúzcoa, Spain. jllop@cicbiomagune.es.
authors.forename: B
authors.initials: B
authors.lastname: Szczupak
authors.affiliation: Molecular Imaging Unit, CIC biomaGUNE, Paseo Miramón 182, 20009 San Sebastián, Guipúzcoa, Spain. jllop@cicbiomagune.es.
authors.forename: U
authors.initials: U
authors.lastname: Cossío
authors.affiliation: Molecular Imaging Unit, CIC biomaGUNE, Paseo Miramón 182, 20009 San Sebastián, Guipúzcoa, Spain. jllop@cicbiomagune.es.
authors.forename: J
authors.initials: J
authors.lastname: Llop