title: Investigating the association between XRCC1 gene polymorphisms and susceptibility to gastric cancer.
abstract: We carried out a hospital-based case-control study to investigate the role of XRCC1 gene Arg399Gln, Arg280His, and Arg194Trp polymorphisms in susceptibility to gastric cancer. A total of 214 gastric cancer patients and 247 control subjects were recruited between March 2013 and March 2015, and polymorphism genotype frequencies were determined by polymerase chain reaction-restriction fragment length polymorphism. Using the chi-square test, we detected statistically significant differences in age (chi-square = 22.25, P < 0.001), gender (chi-square = 6.74, P = 0.01), and family history of cancer (chi-square = 4.73, P = 0.03) between the case and control groups. Logistic regression analysis revealed that the XRCC1 Arg194Trp TT genotype conferred increased susceptibility to gastric cancer compared to the CC genotype [odds ratio (OR) = 2.38, 95% confidence interval (CI) = 1.28-4.49]. Moreover, individuals carrying the T allele of this variant were found to be at moderately increased risk of this disease (OR = 1.56, 95%CI = 1.16-2.09). However, the XRCC1 Arg399Gln and Arg280His polymorphisms were shown to have no influence on the development of gastric cancer. In conclusion, we suggest that the XRCC1 gene Arg194Trp polymorphism is associated with gastric cancer susceptibility in the Chinese population.
authors.affiliation: Department of Gastroenterology, Anhui Provincial Hospital, Hefei, China sichensc11@163.com.
authors.forename: S
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology, Anhui Provincial Hospital, Hefei, China.
authors.forename: X C
authors.initials: XC
authors.lastname: Zhu
authors.affiliation: Department of Gastroenterology, Anhui Provincial Hospital, Hefei, China.
authors.forename: Y L
authors.initials: YL
authors.lastname: Liu
authors.affiliation: Department of Gastroenterology, Anhui Provincial Hospital, Hefei, China.
authors.forename: C
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology, Anhui Provincial Hospital, Hefei, China.
authors.forename: K G
authors.initials: KG
authors.lastname: Zhang
mesh_terms: D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D013274:Stomach Neoplasms / Q000235:genetics*; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human