title: Characteristics of carcinogenic human papillomavirus infection in Suzhou: Epidemiology, vaccine evaluation, and associated diseases.
abstract: Human papillomavirus infection is a major health problem and caused substantial benign and malignancy diseases among female and male worldwide. We aim to investigate the epidemiology of high-risk human papillomavirus (HR-HPV) and related diseases in Suzhou population. As well as evaluating the potential benefit of a nine-valent HPV vaccine (regardless of HPV-6 and -11) in Suzhou. A total of 40,108 people aged 13-89 years were retrospectively examined by database retrieval from 2010 to 2015. Thirteen genotypes (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 66) of HR-HPV were detected using Tellgenplex™ xMAP™ HPV DNA Test assay. The overall prevalence of HR-HPV was 21.1%, the female and male account for 96.4% and 3.6%, respectively. The infection rate among male (25.6%, 367/1,432) was significantly higher than that among female (20.9%, 8,100/38,676), X2= 17.341 (P < 0.001), with OR = 1.293, 95% CI (1.146-1.460). The five most frequent HR-HPV genotypes were HPV-16 (5.12%), -52 (5.07%), -58 (3.02%), -39 (2.00%), and -18 (1.74%). HR-HPV infection rate was peak in person aged <20 years, and second higher in person aged 51-60 years. Infection modes as HPV-16, -18, -31, -33, -45, -52, -58 alone or mixed accounted for 63.2%. The top three prevalent diseases in HR-HPV infected women were cervicitis, vaginitis, and cervical lesions, and in men were verruca, urethritis, and balanitis, respectively. This is the first study to demonstrate HPV infection status in Suzhou population. Both women and men had a large burden of HPV infection. The nine-valent HPV prophylactic vaccines may potentially prevent 63.2% HR-HPV infection in Suzhou. J. Med. Virol. 89:895-901, 2017. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Clinical Laboratory, Suzhou Municipal Hospital Affiliated to Nanjing Medical University, Suzhou, China.
authors.forename: Wen Jing
authors.initials: WJ
authors.lastname: Li
authors.affiliation: Department of Clinical Laboratory, Suzhou Municipal Hospital Affiliated to Nanjing Medical University, Suzhou, China.
authors.forename: Hong Xing
authors.initials: HX
authors.lastname: Xu
authors.affiliation: Department of Clinical Laboratory, Suzhou Municipal Hospital Affiliated to Nanjing Medical University, Suzhou, China.
authors.forename: Zhao Hua
authors.initials: ZH
authors.lastname: Chen
authors.affiliation: Department of Clinical Laboratory, Suzhou Municipal Hospital Affiliated to Nanjing Medical University, Suzhou, China.
authors.forename: Wei Dong
authors.initials: WD
authors.lastname: Xu
authors.affiliation: Department of Clinical Laboratory, Suzhou Municipal Hospital Affiliated to Nanjing Medical University, Suzhou, China.
authors.forename: Yuan Jian
authors.initials: YJ
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D005838:Genotype; D060005:Genotyping Techniques; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000517:prevention & control / Q000821:virology*; D053918:Papillomavirus Vaccines / Q000276:immunology*; D015995:Prevalence; D060737:Reproductive Tract Infections / Q000453:epidemiology / Q000821:virology; D012189:Retrospective Studies; D014777:Virus Diseases; D014860:Warts / Q000453:epidemiology / Q000821:virology; D055815:Young Adult
chemical_list: D004279:DNA, Viral; D053918:Papillomavirus Vaccines
keywords: genotype; high risk (HR); human papillomavirus (HPV); prevalence; vaccine