title: Ruthenium-catalyzed direct α-alkylation of amides using alcohols.
abstract: The highly efficient direct α-alkylation of unactivated amides has been accomplished using alcohols in the presence of the Ru-PNN catalyst (0.1 mol%) with a high turnover number. Using this approach, 2-oxindole was directly transformed into C3-alkylated 3-hydroxyindolin-2-one in one step without the use of any oxidant.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research, Pune 411008, India. gnanaprakasam@iiserpune.ac.in.
authors.forename: Moreshwar Bhagwan
authors.initials: MB
authors.lastname: Chaudhari
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research, Pune 411008, India. gnanaprakasam@iiserpune.ac.in.
authors.forename: Girish Singh
authors.initials: GS
authors.lastname: Bisht
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research, Pune 411008, India. gnanaprakasam@iiserpune.ac.in.
authors.forename: Pooja
authors.initials: P
authors.lastname: Kumari
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research, Pune 411008, India. gnanaprakasam@iiserpune.ac.in.
authors.forename: Boopathy
authors.identifier: http://orcid.org/0000-0002-3047-9636
authors.initials: B
authors.lastname: Gnanaprakasam