title: Targeting the complex interactions between microbiota, host epithelial and immune cells in inflammatory bowel disease.
abstract: Inflammatory bowel disease (IBD) is a chronic inflammatory intestinal disorder that includes two distinct disease categories: ulcerative colitis and Crohn's disease. Epidemiological, genetic, and experimental studies have revealed many important aspects of IBD. Genetic susceptibility, inappropriate immune responses, environmental changes, and intestinal microbiota are all associated with the development of IBD. However, the exact mechanisms of the disease and the interactions among these pathogenic factors are largely unknown. Here we introduce recent findings from experimental colitis models that investigated the interactions between host genetic susceptibility and gut microbiota. In addition, we discuss new strategies for the treatment of IBD, focusing on the complex interactions between microbiota and host epithelial and immune cells.
authors.affiliation: Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 113-8655 Tokyo, Japan. Electronic address: Hiratay-int@h.u-tokyo.ac.jp.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Hirata
authors.affiliation: Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 113-8655 Tokyo, Japan.
authors.forename: Sozaburo
authors.initials: S
authors.lastname: Ihara
authors.affiliation: Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 113-8655 Tokyo, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Koike
mesh_terms: D000818:Animals; D020022:Genetic Predisposition to Disease / Q000209:etiology / Q000235:genetics; D054884:Host-Pathogen Interactions / Q000187:drug effects* / Q000235:genetics / Q000276:immunology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology / Q000382:microbiology; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000382:microbiology; D064307:Microbiota / Q000187:drug effects* / Q000276:immunology
keywords: Dysbiosis; Genetic susceptibility; Inflammatory bowel disease; Knockout mouse; Microbiota; Therapy