title: Chloroacetate Promotes and Participates in the Oxidative Annulation of Pyridines/Isoquinoline by Using Oxygen as the Oxidant.
abstract: The aerobic oxidative annulation of chalcones, pyridines/isoquinoline and ethyl chloroacetate to indolizines was achieved by cascade reaction. Various functional groups on chalcones were tolerated. And different pyridines derivatives could also be suitable substrates. Ethyl chloroacetate is an essential component in participating of the oxidative annulation process. Overall, this protocol is very practical and efficient by using molecular oxygen as oxidant with high selectivity for the annulation product.
authors.affiliation: Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Key Laboratory of Boron Chemistry and Advanced Energy Materials, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan, 453007, P. R. China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Yue
authors.affiliation: Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Key Laboratory of Boron Chemistry and Advanced Energy Materials, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan, 453007, P. R. China.
authors.forename: Yangyang
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Key Laboratory of Boron Chemistry and Advanced Energy Materials, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan, 453007, P. R. China.
authors.forename: Shufang
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Key Laboratory of Boron Chemistry and Advanced Energy Materials, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan, 453007, P. R. China.
authors.forename: Xuyang
authors.initials: X
authors.lastname: Yan
authors.affiliation: Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Key Laboratory of Boron Chemistry and Advanced Energy Materials, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan, 453007, P. R. China.
authors.forename: Rong
authors.initials: R
authors.lastname: Li
authors.affiliation: Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Key Laboratory of Boron Chemistry and Advanced Energy Materials, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan, 453007, P. R. China.
authors.forename: Yaru
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Key Laboratory of Boron Chemistry and Advanced Energy Materials, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan, 453007, P. R. China.
authors.forename: Kelei
authors.initials: K
authors.lastname: Zhuo
authors.affiliation: Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Key Laboratory of Boron Chemistry and Advanced Energy Materials, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan, 453007, P. R. China.
authors.forename: Jianming
authors.initials: J
authors.lastname: Liu
keywords: cascade reactions; dioxygen; oxidative annulation; substituted indolizines; α,β-unsaturated carbonyl compounds