title: Measurement of biofilm growth and local hydrodynamics using optical coherence tomography.
abstract: We report on localized and simultaneous measurement of biofilm growth and local hydrodynamics in a microfluidic channel using optical coherence tomography. We measure independently with high spatio-temporal resolution the longitudinal flow velocity component parallel to the imaging beam and the transverse flow velocity component perpendicular to the imaging beam. Based on the measured velocities we calculate the shear-rates in the flow channel. We show the relation between the measured biofilm structure and flow velocities as biofilm growth progresses over the course of 48 hours.
authors.affiliation: Biomedical Engineering & Physics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands.
authors.forename: Nicolás
authors.initials: N
authors.lastname: Weiss
authors.affiliation: Soft Matter, Fluidics and Interfaces, MESA+ Institute for Nanotechnology, Faculty of Science and Technology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
authors.forename: Khalid El Tayeb El
authors.initials: KE
authors.lastname: Obied
authors.affiliation: Department of Imaging Physics, Faculty of Applied Sciences, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, The Netherlands.
authors.forename: Jeroen
authors.initials: J
authors.lastname: Kalkman
authors.affiliation: Soft Matter, Fluidics and Interfaces, MESA+ Institute for Nanotechnology, Faculty of Science and Technology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
authors.forename: Rob G H
authors.initials: RG
authors.lastname: Lammertink
authors.affiliation: Biomedical Engineering & Physics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands.
authors.forename: Ton G
authors.initials: TG
authors.lastname: van Leeuwen
keywords: (170.3880) Medical and biological imaging; (170.4500) Optical coherence tomography; (280.7250) Velocimetry