title: Chronic obstructive airway disease among patients hospitalized with acute heart failure; clinical characteristics, precipitating factors, management and outcome: Observational report from the Middle East.
abstract: BACKGROUND
  The purpose of this study was to report the prevalence, clinical characteristics, contributing factors, management and outcome of patients with chronic obstructive pulmonary disease (COPD) among patients hospitalized with heart failure (HF).
  
  
  METHODS
  Data were derived from Gulf Care (Gulf acute heart failure registry), a prospective multicenter study of 5005 consecutive patients hospitalized with acute heart failure during February to November 2012 in seven Middle Eastern countries. Data were described and compared for demographics, management and outcomes.
  
  
  RESULTS
  The prevalence of COPD among HF patients was 10%. COPD patients were older, more likely to be female and to have diabetes, hypertension, chronic kidney disease and sleep apnea (P = 0.001 for all) when compared to non-COPD patients. Contributing factors for hospitalization were systemic infection and atrial arrhythmias in COPD patients compared to acute coronary syndrome, uncontrolled hypertension and anemia in the non-COPD patients. Left-ventricular ejection fraction was higher in COPD patients; while BNP levels were comparable between the two groups. Non-invasive ventilation was used more frequently among COPD patients compared to non-COPD patients (P = 0.001). On multivariate logistic regression analysis, COPD was not associated with increased risk in-hospital and one-year death among acute heart failure (AHF) population and β blockers treatment appear to have neutral mortality effect in COPD patients with HF.
  
  
  CONCLUSIONS
  COPD have distinct cardiovascular risk profile and precipitating factors for hospitalization with HF when compared to non-COPD patients. COPD history had no impact on the short-term and one-year mortality.
authors.affiliation: a Department of Cardiology , Saint Michael's Hospital, Toronto University , Toronto , Canada.
authors.forename: Hadi A R
authors.initials: HA
authors.lastname: Khafaji
authors.affiliation: b Biostatistics Section, Department of Cardiology , Royal Hospital , Muscat , Oman.
authors.forename: Kadhim
authors.initials: K
authors.lastname: Sulaiman
authors.affiliation: c Cardiovascular Research, Heart Hospital, Hamad Medical Corporation , Doha , Qatar.
authors.forename: Rajvir
authors.initials: R
authors.lastname: Singh
authors.affiliation: d Department of Cardiac Sciences , King Fahad Cardiac Center, King Saud University , Riyadh , Saudi Arabia.
authors.forename: Khalid F
authors.initials: KF
authors.lastname: Alhabib
authors.affiliation: e Adult Cardiology, Heart Hospital, Hamad Medical Corporation , Doha , Qatar.
authors.forename: Nidal
authors.initials: N
authors.lastname: Asaad
authors.affiliation: f Department of Cardiology , Sheikh Khalifa Medical City , Abu Dhabi , United Arab Emirates.
authors.forename: Alawi
authors.initials: A
authors.lastname: Alsheikh-Ali
authors.affiliation: g Department of Cardiology , Sabah Al-Ahmed Cardiac Center , Kuwait City , Kuwait.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Al-Jarallah
authors.affiliation: g Department of Cardiology , Sabah Al-Ahmed Cardiac Center , Kuwait City , Kuwait.
authors.forename: Bassam
authors.initials: B
authors.lastname: Bulbanat
authors.affiliation: e Adult Cardiology, Heart Hospital, Hamad Medical Corporation , Doha , Qatar.
authors.forename: Wael
authors.initials: W
authors.lastname: Almahmeed
authors.affiliation: h Department of Cardiology , Adan Hospital , Hadiya , Kuwait.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ridha
authors.affiliation: i Department of Cardiology , Dubai Hospital , Dubai , United Arab Emirates.
authors.forename: Nooshin
authors.initials: N
authors.lastname: Bazargani
authors.affiliation: j Department of Cardiology , Mohammed Bin Khalifa Cardiac Center , Manamah , Bahrain.
authors.forename: Haitham
authors.initials: H
authors.lastname: Amin
authors.affiliation: k Department of Cardiology , Faculty of Medicine, Sana'a University , Sana'a , Yemen.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Al-Motarreb
authors.affiliation: l Department of Cardiology and Cardiovascular Surgery , Security Forces Hospital , Riyadh , Saudi Arabia.
authors.forename: Husam Al
authors.initials: HA
authors.lastname: Faleh
authors.affiliation: m Department of Cardiology , Prince Salman Heart Center , King Fahad Medical City , Saudi Arabia.
authors.forename: Abdelfatah
authors.initials: A
authors.lastname: Elasfar
authors.affiliation: b Biostatistics Section, Department of Cardiology , Royal Hospital , Muscat , Oman.
authors.forename: Prashanth
authors.initials: P
authors.lastname: Panduranga
authors.affiliation: c Cardiovascular Research, Heart Hospital, Hamad Medical Corporation , Doha , Qatar.|e Adult Cardiology, Heart Hospital, Hamad Medical Corporation , Doha , Qatar.
authors.forename: Jassim Al
authors.initials: JA
authors.lastname: Suwaidi
mesh_terms: D000208:Acute Disease; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000368:Aged; D015897:Comorbidity; D019468:Disease Management; D005260:Female; D006333:Heart Failure / Q000453:epidemiology* / Q000503:physiopathology / Q000628:therapy; D017052:Hospital Mortality / Q000639:trends; D006801:Humans; D007297:Inpatients; D008297:Male; D008875:Middle Aged; D008877:Middle East / Q000453:epidemiology; D063087:Noninvasive Ventilation / Q000379:methods*; D015985:Precipitating Factors; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology* / Q000503:physiopathology / Q000628:therapy; D012042:Registries; D012307:Risk Factors; D013318:Stroke Volume / Q000502:physiology
chemical_list: D000319:Adrenergic beta-Antagonists
keywords: COPD; heart failure; morbidity; mortality