title: Contribution of IVIM to Conventional Dynamic Contrast-Enhanced and Diffusion-Weighted MRI in Differentiating Benign from Malignant Breast Masses.
abstract: BACKGROUND
  The aim of this study was to determine whether the indicators obtained from intravoxel incoherent motion (IVIM) imaging can improve the characterization of benign and malignant breast masses compared with conventional dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted magnetic resonance imaging (DW-MRI).
  
  
  METHODS
  This study included 23 benign and 31 malignant breast masses of 48 patients. Main indicators were initial enhancement ratio (IER), time-signal intensity curve (TIC), apparent diffusion coefficient (ADC), tissue diffusivity (D), pseudodiffusivity (D*), and perfusion fraction (f). The discriminative abilities of the different models were compared by means of receiver operating characteristic (ROC) curve and area under the ROC curve (AUC) analysis.
  
  
  RESULTS
  D had the highest AUC (0.980), sensitivity (93.55%), specificity (100%), and diagnostic accuracy (96.36%). Both D and TIC could provide the independent predicted features for malignant breast masses. The combination of D and TIC had an AUC of up to 0.990.
  
  
  CONCLUSIONS
  D of IVIM can effectively complement existing conventional DCE-MRI and DW-MRI in differentiating malignant from benign breast masses. IVIM combined with DCE-MRI is a robust means of evaluating breast masses.
authors.affiliation: Department of Radiology, Chinese Navy General Hospital of PLA, Beijing, China.
authors.forename: Qingjun
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Radiology, Chinese Navy General Hospital of PLA, Beijing, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Department of Radiology, Chinese Navy General Hospital of PLA, Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Chinese Navy General Hospital of PLA, Beijing, China.
authors.forename: Zijun
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Radiology, Chinese Navy General Hospital of PLA, Beijing, China.
authors.forename: Minhua
authors.initials: M
authors.lastname: Huang
authors.affiliation: Department of Radiology, Chinese Navy General Hospital of PLA, Beijing, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
keywords: Breast cancer; Diffusion-weighted MRI; Dynamic contrast- enhanced MRI; Intravoxel incoherent motion; Magnetic resonance imaging