title: Combination Therapy with Olmesartan and Amlodipine in the Treatment of Hypertension.
abstract: BACKGROUND
  Combination therapy with antihypertensive agents utilises different mechanisms of action and may be responsible for a more effective decrease in blood pressure.
  
  
  OBJECTIVE
  To review the recently published trials on efficacy and safety of the combination therapy with olmesartan and amlodipine.
  
  
  RESULTS
  The double-blind American COACH (Combination of Olmesartan Medoxomil and Amlopdine Besylate in Controlling High Blood Pressure) study (2008) showed in 1,940 patients that after eight weeks of treatment the BP goals were most frequently achieved in the 'combination therapy group', with 56.3% (54.1-58.5%) and 54.0% (51.8-56.2%) of patients reaching adequate blood pressure of.
authors.affiliation: Academic Medical Centre, Amsterdam, The Netherlands. m.g.niemeyer@gmail.com.
authors.forename: Menco G
authors.initials: MG
authors.lastname: Niemeijer
authors.affiliation: Albert Schweitzer Hospital, Dordrecht, The Netherlands. tj.cleophas@gmail.com.
authors.forename: Ton J
authors.initials: TJ
authors.lastname: Cleophas
keywords: amlodipine; combination therapy; hypertension; olmesartan