title: Allogeneic stem cell transplantation in a blast-phase chronic myeloid leukemia patient with carbapenem-resistantKlebsiella pneumoniaetricuspid valve endocarditis: A case report.
abstract: In chronic myeloid leukemia (CML), the occurrence of blastic transformation is rare. Treatment outcome is generally poor. Allogeneic stem cell transplantation (allo-SCT) is the only potentially curative treatment option for advanced-phase CML. Infections caused by carbapenem-resistantKlebsiella pneumoniae(CRKP) isolates are associated with high morbidity and mortality rates, particularly in patients with haematological malignancies. Infection and colonization by these multiresistant bacteria may represent a challenge in SCT recipients for the management of post-transplantation complications, as well as for the eligibility to receive a transplant in patients who acquire the pathogen prior to the procedure. We herein report the case of a blast-phase CML patient with a highly resistant, CRKP-associated tricuspid valve endocarditis, who was treated with a combination of systemic antimicrobial therapy and surgical valve repair, and subsequently underwent a successful allo-SCT.
authors.affiliation: Division of Hematology, Department of Internal Medicine, Istanbul Medipol University, 34214 Istanbul, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Kantarcioglu
authors.affiliation: Division of Hematology, Department of Internal Medicine, Istanbul Medipol University, 34214 Istanbul, Turkey.
authors.forename: Huseyin Saffet
authors.initials: HS
authors.lastname: Bekoz
authors.affiliation: Department of Cardiology, Istanbul Medipol University, 34214 Istanbul, Turkey.
authors.forename: Fatih Erkam
authors.initials: FE
authors.lastname: Olgun
authors.affiliation: Department of Cardiology, Istanbul Medipol University, 34214 Istanbul, Turkey.
authors.forename: Beytullah
authors.initials: B
authors.lastname: Cakal
authors.affiliation: Department of Cardiovascular Surgery, Istanbul Medipol University, 34214 Istanbul, Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Arkan
authors.affiliation: Department of Cardiovascular Surgery, Istanbul Medipol University, 34214 Istanbul, Turkey.
authors.forename: Halil
authors.initials: H
authors.lastname: Turkoglu
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Istanbul Medipol University, 34214 Istanbul, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Mert
authors.affiliation: Division of Hematology, Department of Internal Medicine, Istanbul Medipol University, 34214 Istanbul, Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Sargin
keywords: allogeneic stem cell transplantation; carbapenem-resistant Klebsiella pneumoniae; infective endocarditis