title: The predictive value of dendritic cells in early squamous cell carcinoma of the tongue.
abstract: OBJECTIVE
  The aim of this study was to evaluate the relationship between dendritic cell density in early squamous cell carcinoma (SCC) of the tongue and patients' clinical outcome.
  
  
  METHODS
  Representative samples of low-risk SCC of the tongue (T1-2,N0,M0) from a homogeneous group of 18 patients following local complete excision and elective selective neck dissection, were immunostained with antibodies against S100 and CD1a. Dendritic cell density was analyzed by outcome.
  
  
  RESULTS
  Mean dendritic cell densities were 17 cells/HPF for tumoral S100 and CD1a counts, and 10 cells/HPF for peritumoral S100 and CD1a counts. Better disease-free survival was associated with low peritumoral S100- and CD1a- positive cell counts (p=0.006 and p=0.004, respectively), and with low tumoral S100- and CD1a- positive cell counts (p=0.037 and p=0.04, respectively). Lymphocytic response was decreased in tumors with high dendritic cell density (p=NS). There was no association of dendritic cell density with patient age, tumor size and depth of invasion.
  
  
  CONCLUSIONS
  These results may suggest an association between dendritic cell accumulation and functional immunologic impairment.
authors.affiliation: Departments of Otolaryngology, Head and Neck Surgery, Rabin Medical Center, Petach Tikva, Affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: ohadhilly@yahoo.com.
authors.forename: Ohad
authors.initials: O
authors.lastname: Hilly
authors.affiliation: Departments of Pathology, Rabin Medical Center, Petach Tikva, Affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Yulia
authors.initials: Y
authors.lastname: Strenov
authors.affiliation: Departments of Pathology, Rabin Medical Center, Petach Tikva, Affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Lea
authors.initials: L
authors.lastname: Rath-Wolfson
authors.affiliation: Departments of Otolaryngology, Head and Neck Surgery, Rabin Medical Center, Petach Tikva, Affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Roy
authors.initials: R
authors.lastname: Hod
authors.affiliation: Departments of Otolaryngology, Head and Neck Surgery, Rabin Medical Center, Petach Tikva, Affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Yotam
authors.initials: Y
authors.lastname: Shkedy
authors.affiliation: Departments of Otolaryngology, Head and Neck Surgery, Rabin Medical Center, Petach Tikva, Affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Aviram
authors.initials: A
authors.lastname: Mizrachi
authors.affiliation: Departments of Pathology, Rabin Medical Center, Petach Tikva, Affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Rumelia
authors.initials: R
authors.lastname: Koren
authors.affiliation: Departments of Otolaryngology, Head and Neck Surgery, Rabin Medical Center, Petach Tikva, Affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Thomas
authors.initials: T
authors.lastname: Shpitzer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002452:Cell Count; D003713:Dendritic Cells / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014059:Tongue / Q000473:pathology; D014062:Tongue Neoplasms / Q000473:pathology*
keywords: Dendritic cells; Disease-free survival; Lymphocytic response; Squamous cell carcinoma; Tongue cancer