title: Potential Impact on Clinical Decision Making via a Genome-Wide Expression Profiling: A Case Report.
abstract: Management of men with prostate cancer is fraught with uncertainty as physicians and patients balance efficacy with potential toxicity and diminished quality of life. Utilization of genomics as a prognostic biomarker has improved the informed decision-making process by enabling more rationale treatment choices. Recently investigations have begun to determine whether genomic information from tumor transcriptome data can be used to impact clinical decision-making beyond prognosis. Here we discuss the potential of genomics to alter management of a patient who presented with high-risk prostate adenocarcinoma. We suggest that this information help selecting patients for advanced imaging, chemotherapies, or clinical trial.
authors.affiliation: Sidney Kimmel Cancer Center, Thomas Jefferson University, PA, USA.
authors.forename: Hyun
authors.initials: H
authors.lastname: Kim
authors.affiliation: GenomeDx Biosciences Inc., Vancouver, BC, Canada.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Alshalalfa
authors.affiliation: Sidney Kimmel Cancer Center, Thomas Jefferson University, PA, USA.
authors.forename: Jean
authors.initials: J
authors.lastname: Hoffman-Censits
authors.affiliation: Sidney Kimmel Cancer Center, Thomas Jefferson University, PA, USA.
authors.forename: Costas D
authors.initials: CD
authors.lastname: Lallas
authors.affiliation: GenomeDx Biosciences Inc., Vancouver, BC, Canada.
authors.forename: Elai
authors.initials: E
authors.lastname: Davicioni
authors.affiliation: Sidney Kimmel Cancer Center, Thomas Jefferson University, PA, USA.
authors.forename: Jianqing
authors.initials: J
authors.lastname: Lin
authors.affiliation: Sidney Kimmel Cancer Center, Thomas Jefferson University, PA, USA.
authors.forename: Ruth
authors.initials: R
authors.lastname: Birbe
authors.affiliation: GenomeDx Biosciences Inc., Vancouver, BC, Canada.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Erho
authors.affiliation: GenomeDx Biosciences Inc., Vancouver, BC, Canada.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Lehrer
authors.affiliation: GenomeDx Biosciences Inc., Vancouver, BC, Canada.
authors.forename: Hussam Al-Deen
authors.initials: HA
authors.lastname: Ashab
authors.affiliation: GenomeDx Biosciences Inc., Vancouver, BC, Canada.
authors.forename: Mandeep
authors.initials: M
authors.lastname: Takhar
authors.affiliation: GenomeDx Biosciences Inc., Vancouver, BC, Canada.
authors.forename: Anders
authors.initials: A
authors.lastname: Olson
authors.affiliation: GenomeDx Biosciences Inc., Vancouver, BC, Canada.
authors.forename: Lucia L C
authors.initials: LL
authors.lastname: Lam
authors.affiliation: Sidney Kimmel Cancer Center, Thomas Jefferson University, PA, USA.
authors.forename: W Kevin
authors.initials: WK
authors.lastname: Kelly
authors.affiliation: Sidney Kimmel Cancer Center, Thomas Jefferson University, PA, USA.
authors.forename: Karen E
authors.initials: KE
authors.lastname: Knudsen
authors.affiliation: Sidney Kimmel Cancer Center, Thomas Jefferson University, PA, USA.
authors.forename: Chellappagounder
authors.initials: C
authors.lastname: Thangavel
authors.affiliation: GenomeDx Biosciences Inc., Vancouver, BC, Canada; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Roland
authors.initials: R
authors.lastname: Seiler
authors.affiliation: Department of Radiation Oncology, University of California, San Francisco, CA, USA.
authors.forename: Felix Y
authors.initials: FY
authors.lastname: Feng
authors.affiliation: Department of Urology, Feinberg School of Medicine, Northwestern University, IL, USA.
authors.forename: Edward M
authors.initials: EM
authors.lastname: Schaeffer
authors.affiliation: Sidney Kimmel Cancer Center, Thomas Jefferson University, PA, USA.
authors.forename: Edouard J
authors.initials: EJ
authors.lastname: Trabulsi
authors.affiliation: Sidney Kimmel Cancer Center, Thomas Jefferson University, PA, USA.
authors.forename: Leonard G
authors.initials: LG
authors.lastname: Gomella
authors.affiliation: Sidney Kimmel Cancer Center, Thomas Jefferson University, PA, USA.
authors.forename: Mark D
authors.initials: MD
authors.lastname: Hurwitz
authors.affiliation: Sidney Kimmel Cancer Center, Thomas Jefferson University, PA, USA.
authors.forename: Adam P
authors.initials: AP
authors.lastname: Dicker
authors.affiliation: Sidney Kimmel Cancer Center, Thomas Jefferson University, PA, USA.
authors.forename: Robert B
authors.initials: RB
authors.lastname: Den
keywords: Genomics; Neuroendocrine; Prostate