title: Effects of sugammadex vs. pyridostigmine-glycopyrrolate on post-operative nausea and vomiting: propensity score matching.
abstract: BACKGROUND
  Sugammadex is a new agent that reverses neuromuscular blockade by aminosteroid neuromuscular blocker. This retrospective study compared the effects of sugammadex on post-operative nausea and vomiting (PONV) with those of a pyridostigmine-glycopyrrolate mixture.
  
  
  METHODS
  We reviewed the electronic medical records of 7179 patients who had received fentanyl-based, intravenous, patient-controlled analgesia (IV-PCA) at Chung-Ang University Hospital between January 1, 2010 and December 31, 2015. We categorized the patients into two groups on the basis of the type of reversal agent to neuromuscular blockade that was used: a traditional reversal agent (pyridostigmine-glycopyrrolate mixture; Group R; n = 7059) and sugammadex (Group S; n = 120). The propensity score matching method was then used to select 408 subjects in Group R and 115 subjects in Group S; on the basis of their covariates, these subjects were then matched with a counterpart in the other group.
  
  
  RESULTS
  After propensity score matching, the two groups were well balanced with respect to all baseline covariates. In Group S, the numeric rating scale of nausea on day 0, as well as the number of patients who vomited on day 0, was lower than that in group R. Furthermore, Group S used fewer rescue antiemetics on day 0 and had a higher complete response on day 0.
  
  
  CONCLUSIONS
  Sugammadex might be more beneficial for PONV compared to pyridostigmine-glycopyrrolate mixture for patients who have received opioid-based IV-PCA.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine, Dongjak-gu, Seoul, Korea.
authors.forename: O H
authors.initials: OH
authors.lastname: Lee
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine, Dongjak-gu, Seoul, Korea.
authors.forename: G J
authors.initials: GJ
authors.lastname: Choi
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine, Dongjak-gu, Seoul, Korea.
authors.forename: H
authors.initials: H
authors.lastname: Kang
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine, Dongjak-gu, Seoul, Korea.
authors.forename: C W
authors.initials: CW
authors.lastname: Baek
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine, Dongjak-gu, Seoul, Korea.
authors.forename: Y H
authors.initials: YH
authors.lastname: Jung
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine, Dongjak-gu, Seoul, Korea.
authors.forename: Y C
authors.initials: YC
authors.lastname: Woo
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine, Dongjak-gu, Seoul, Korea.
authors.forename: J
authors.initials: J
authors.lastname: Oh
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine, Dongjak-gu, Seoul, Korea.
authors.forename: Y H
authors.initials: YH
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006024:Glycopyrrolate / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000453:epidemiology; D020250:Postoperative Nausea and Vomiting / Q000453:epidemiology*; D057216:Propensity Score; D011729:Pyridostigmine Bromide / Q000494:pharmacology*; D012189:Retrospective Studies; D000077122:Sugammadex; D047408:gamma-Cyclodextrins / Q000494:pharmacology*
chemical_list: D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D011729:Pyridostigmine Bromide; D006024:Glycopyrrolate