title: Association of HLA-A and Non-Classical HLA Class I Alleles.
abstract: The HLA-A locus is surrounded by HLA class Ib genes: HLA-E, HLA-H, HLA-G and HLA-F. HLA class Ib molecules are involved in immuno-modulation with a central role for HLA-G and HLA-E, an emerging role for HLA-F and a yet unknown function for HLA-H. Thus, the principal objective of this study was to describe the main allelic associations between HLA-A and HLA-H, -G, -F and -E. Therefore, HLA-A, -E, -G, -H and -F coding polymorphisms, as well as HLA-G UnTranslated Region haplotypes (referred to as HLA-G UTRs), were explored in 191 voluntary blood donors. Allelic frequencies, Global Linkage Disequilibrium (GLD), Linkage Disequilibrium (LD) for specific pairs of alleles and two-loci haplotype frequencies were estimated. We showed that HLA-A, HLA-H, HLA-F, HLA-G and HLA-G UTRs were all in highly significant pairwise GLD, in contrast to HLA-E. Moreover, HLA-A displayed restricted associations with HLA-G UTR and HLA-H. We also confirmed several associations that were previously found to have a negative impact on transplantation outcome. In summary, our results suggest complex functional and clinical implications of the HLA-A genetic region.
authors.affiliation: Etablissement Français du Sang Alpes Méditerranée, Marseille, France.|Aix Marseille Univ, CNRS, EFS, ADES, "Biologie des Groupes Sanguins", Marseille, France.
authors.forename: Federico
authors.initials: F
authors.lastname: Carlini
authors.affiliation: Aix Marseille Univ, CNRS, EFS, ADES, "Biologie des Groupes Sanguins", Marseille, France.
authors.forename: Virginia
authors.initials: V
authors.lastname: Ferreira
authors.affiliation: Laboratory of Anthropology, Genetics and Peopling history (AGP), Department of Genetics and Evolution-Anthropology Unit, University of Geneva, Geneva, Switzerland.|Transplantation Immunology Unit and National Reference Laboratory for Histocompatibility, Department of Genetic and Laboratory Medicine, Geneva University Hospitals, Geneva, Switzerland.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Buhler
authors.affiliation: Etablissement Français du Sang Alpes Méditerranée, Marseille, France.|Aix Marseille Univ, CNRS, EFS, ADES, "Biologie des Groupes Sanguins", Marseille, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Tous
authors.affiliation: Department of Immunology, CHRU de Montpellier, University Hospital Saint-Eloi, Montpellier, France.|Faculté de Médecine, University of Montpellier 1, Montpellier, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Eliaou
authors.affiliation: Department of Immunology, CHRU de Montpellier, University Hospital Saint-Eloi, Montpellier, France.|Faculté de Médecine, University of Montpellier 1, Montpellier, France.
authors.forename: Céline
authors.initials: C
authors.lastname: René
authors.affiliation: Etablissement Français du Sang Alpes Méditerranée, Marseille, France.|Aix Marseille Univ, CNRS, EFS, ADES, "Biologie des Groupes Sanguins", Marseille, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Chiaroni
authors.affiliation: Etablissement Français du Sang Alpes Méditerranée, Marseille, France.|Aix Marseille Univ, CNRS, EFS, ADES, "Biologie des Groupes Sanguins", Marseille, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Picard
authors.affiliation: Etablissement Français du Sang Alpes Méditerranée, Marseille, France.|Aix Marseille Univ, CNRS, EFS, ADES, "Biologie des Groupes Sanguins", Marseille, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Di Cristofaro
mesh_terms: D000483:Alleles; D005602:France; D005787:Gene Frequency; D056426:Genetic Loci; D005838:Genotype; D015234:HLA-A Antigens / Q000235:genetics*; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide
chemical_list: D015234:HLA-A Antigens; D015395:Histocompatibility Antigens Class I