title: Effect of Preliminary Injection of Bone Marrow Cell Total RNA on Erythropoiesis Recovery Dynamics in Rats Exposed to an Acute γ-Irradiation.
abstract: Total RNA from the bone marrow of healthy donor rats was injected to experimental rats 6 h, 2 h, or 30 min prior to a single γ-irradiation in the sublethal dose of 6 Gy. Injection total RNA 30 min prior to the exposure most effectively restored erythropoiesis in experimental animals. In 5 days, reticulocyte count in these animals 30-fold surpassed the control (injection of 0.9% NaCl). In 12 days, the content of new erythroblastic islands in the bone marrow in rats injected with the total RNA 2 h or 30 min prior to irradiation increased significantly and erythropoiesis recovery activation was observed.
authors.affiliation: V. N. Orekhovich Research Institute of Biomedical Chemistry, the Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: N M
authors.initials: NM
authors.lastname: Gevorkyan
authors.affiliation: South Ural State Medical University, Chelyabinsk, Russia. natalya-tishevskaya@yandex.ru.
authors.forename: N V
authors.initials: NV
authors.lastname: Tishevskaya
authors.affiliation: South Ural State Medical University, Chelyabinsk, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Bolotov
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D001854:Bone Marrow Cells / Q000187:drug effects / Q000502:physiology; D004353:Drug Evaluation, Preclinical; D004920:Erythropoiesis / Q000187:drug effects* / Q000528:radiation effects; D005720:Gamma Rays; D008297:Male; D012313:RNA / Q000008:administration & dosage*; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D051381:Rats
chemical_list: D011837:Radiation-Protective Agents; D012313:RNA
keywords: RNA; erythroblastic island; erythropoiesis; radioprotective preparations; γ-irradiation