title: Solution Conformations of Curcumin in DMSO.
abstract: NAMFIS (NMR Analysis of Molecular Flexibility In Solution) has been applied to curcumin dissolved in DMSO. Quantitative1H-1H distance constraints reduce a pool of candidate conformations to a solution collection of four enol conformations-two of these match curcumin crystallized with human transthyretin, and one is closely related to a single-crystal structure of curcumin.
authors.affiliation: School of Chemistry and Physics, University of KwaZulu-Natal , Pietermaritzburg, South Africa 3209.
authors.forename: Cathryn A
authors.initials: CA
authors.lastname: Slabber
authors.affiliation: School of Chemistry and Physics, University of KwaZulu-Natal , Pietermaritzburg, South Africa 3209.
authors.forename: Craig D
authors.initials: CD
authors.lastname: Grimmer
authors.affiliation: School of Chemistry and Physics, University of KwaZulu-Natal , Pietermaritzburg, South Africa 3209.
authors.forename: Ross S
authors.initials: RS
authors.lastname: Robinson
mesh_terms: D018360:Crystallography, X-Ray; D003474:Curcumin / Q000737:chemistry*; D004121:Dimethyl Sulfoxide / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012996:Solutions
chemical_list: D012996:Solutions; D003474:Curcumin; D004121:Dimethyl Sulfoxide