title: Outcomes of Parathyroid Autotransplantation During Total Thyroidectomy: A Comparison with Age- and Sex-Matched Controls.
abstract: OBJECTIVE
  To determine the effect of parathyroid autotransplantation (PA) on postoperative hypocalcemia in cases of total thyroidectomy.
  
  
  METHODS
  Cases undergoing total thyroidectomy and PA were compared with age and sex-matched controls who had not undergone PA. The postoperative percentage changes (PC) of parathyroid hormone (PTH) and calcium (Ca+2) in the first 12-24 hours (12-24hr→preop), between the 1st-3rd weeks (1-3wk→preop) and at the 6th month (6mo→preop), the rates of hypocalcemia (Ca+2< 8mg/dL) and low PTH level (PTH< 15 pg/mL), permanent hypocalcemia, inadvertent parathyroidectomy in both groups were compared.
  
  
  RESULTS
  The number of patients with PTH12-24hr<15 pg/mL was significantly higher (n:34,(55.7%)) than the number of patients in the control group (n:16(26.2%)), (p=0.001). The rate of decrease in the blood Ca+2 median PC (6mo→preop) was significantly higher in the PA group (4.2%) than the control group (1.1%), (p=0.008). There was no significant difference between the 2 groups in terms of the postoperative frequency of hypocalcemia (p>0.05). In the PA&age≤50 group, the rate of inadvertent parathyroidectomy was higher than that of cases over age 50 (p=0.029).
  
  
  CONCLUSIONS
  In spite of the presence of an increased postoperative hypocalcemia trend in cases requiring PA during total thyroidectomy, the rates of transient and permanent hypocalcemia were not different to the control cases. But the frequency of cases with low PTH level in cases undergoing PA was higher than that of the control cases. In cases of 50 years of age and under, who had undergone PA, the possibility of inadvertent parathyroidectomy increased.
authors.affiliation: a Department of Surgery , Uludag University Faculty of Medicine , Bursa , Turkey.
authors.forename: Turkay
authors.initials: T
authors.lastname: Kirdak
authors.affiliation: a Department of Surgery , Uludag University Faculty of Medicine , Bursa , Turkey.
authors.forename: Halit Ziya
authors.initials: HZ
authors.lastname: Dundar
authors.affiliation: b Department of Surgery , Sanko University School of Medicine , Gaziantep , Turkey.
authors.forename: Erdal
authors.initials: E
authors.lastname: Uysal
authors.affiliation: c Department of Biostatistics , Uludag University Faculty of Medicine , Bursa , Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Ocakoglu
authors.affiliation: a Department of Surgery , Uludag University Faculty of Medicine , Bursa , Turkey.
authors.forename: Nusret
authors.initials: N
authors.lastname: Korun
mesh_terms: D000328:Adult; D002118:Calcium / Q000097:blood; D005260:Female; D006044:Goiter, Nodular; D006801:Humans; D006996:Hypocalcemia / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D061646:Operative Time; D010280:Parathyroid Glands / Q000637:transplantation*; D010281:Parathyroid Hormone / Q000097:blood; D011183:Postoperative Complications / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D012189:Retrospective Studies; D013965:Thyroidectomy / Q000009:adverse effects*; D014182:Transplantation, Autologous
chemical_list: D010281:Parathyroid Hormone; D002118:Calcium
keywords: Parathyroid autotransplantation; hypocalcemia; inadvertent parathyroidectomy; parathormone; thyroidectomy