title: Knockdown of Latent Transforming Growth Factor-β (TGF-β)-Binding Protein 2 (LTBP2) Inhibits Invasion and Tumorigenesis in Thyroid Carcinoma Cells.
abstract: Latent transforming growth factor-β (TGF-β)-binding protein 2 (LTBP2) is one of four proteins in the LTBP family of proteins (LTBP1-4) and was shown to play a vital role in tumorigenesis. However, little is known regarding the functional role of LTBP2 in thyroid carcinoma. Therefore, the current study aimed to evaluate the effect of LTBP2 expression on the proliferation, invasion, and tumorigenesis in thyroid carcinoma cells and to explore the molecular mechanism of LTBP2 in tumor progression. Our results showed that the expression of LTBP2 is upregulated in human thyroid carcinoma and cell lines. Knockdown of LTBP2 inhibits the proliferation, invasion, and EMT phenotype in thyroid carcinoma cells. Furthermore, knockdown of LTBP2 attenuates thyroid carcinoma growth in nude mice. Finally, knockdown of LTBP2 inhibits activation of the PI3K/Akt pathway in thyroid carcinoma cells. In summary, the present study has provided further evidence that knockdown of LTBP2 inhibits invasion and tumorigenesis in thyroid carcinoma cells. Our findings may help to further elucidate the molecular mechanisms underlying thyroid carcinoma progression and provide candidate targets for the prevention and treatment of thyroid carcinoma.
authors.affiliation: Department of Head and Neck Surgery, Linyi Tumor Hospital, Linyi, P.R. China.
authors.forename: Fuqiang
authors.initials: F
authors.lastname: Wan
authors.affiliation: Department of Head and Neck Surgery, Linyi Tumor Hospital, Linyi, P.R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Peng
authors.affiliation: Department No. 2 of Abdominal Surgery, Linyi Tumor Hospital, Linyi, P.R. China.
authors.forename: ChaoYu
authors.initials: C
authors.lastname: Zhu
authors.affiliation: Department of Breast Surgery, Linyi Tumor Hospital, Linyi, P.R. China.
authors.forename: XinFa
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Head and Neck Surgery, Linyi Tumor Hospital, Linyi, P.R. China.
authors.forename: FangWen
authors.initials: F
authors.lastname: Chen
authors.affiliation: Department of General Surgery, Linyi People's Hospital, Linyi, P.R. China.
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000378:metabolism; D004195:Disease Models, Animal; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics; D015870:Gene Expression; D055785:Gene Knockdown Techniques; D064593:Heterografts; D006801:Humans; D053779:Latent TGF-beta Binding Proteins / Q000235:genetics*; D051379:Mice; D009361:Neoplasm Invasiveness; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D015398:Signal Transduction; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*
chemical_list: C509035:LTBP2 protein, human; D053779:Latent TGF-beta Binding Proteins; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt