title: Tetraazacalix[2]arence[2]triazine Coated Fe3O4/SiO2Magnetic Nanoparticles for Simultaneous Dispersive Solid Phase Extraction and Determination of Trace Multitarget Analytes.
abstract: To satisfy the requirement of simultaneous extraction and characterization of diverse kinds of multitarget analytes, the preparation, characterization, and application of a novel tetraazacalix[2]arene[2]triazine (TCT) coated magnetic nanoparticle (TCT MNP) adsorbent are presented in this paper. TCT assembles two benzene rings and two triazines with nitrogen cross-bridging links, which exhibits a unique structural framework and versatile recognition features based on the multiple recognition sites. These include π electron stacking, charge transfer, hydrogen bonding, and ion-exchange. TCT MNPs acted as a dispersive SPE adsorbent showing strong interaction with and adsorption of polycyclic aromatic hydrocarbons (PAHs), nitroaromatics, and heavy metal ions. The dispersive magnetic nanoparticle solid phase extraction (d-MNSPE) strategy with the simultaneous extraction and stepwise elution (SESE) procedure was designed and optimized for the five PAHs (phenanthrene, anthracene, pyrene, chrysene, and benzo(a)pyrene), six nitroaromatics (4-nitrotoluene, 2,4-dinitrotoluene, 2,4,6-trinitrotoluene, 4-nitrophenol, 2,4-dinitrophenol, and 2,4,6-trinitrophenol), and four metal ions (Cu, Zn, Mn, Cd) in aqueous samples. Due to the high stability, desirable durability, larger saturation magnetization, reuse and distinct enrichment capacity of TCT MNPs, the d-MNSPE method with the SESE strategy provided high recovery (>90%) and good precision (relative standard deviations, RSD < 10%). Coupled with the commonly used HPLC-fluorescence detection, HPLC-UV detection, and atomic absorption spectrometry, these trace probes in tap water, river water, and lake water were determined with very low detection limits, in the range of 0.09-0.15 pg mL-1for PAHs, 6-11 pg mL-1for nitroaromatics, and 17-53 pg mL-1for metal ions after being enriched by the d-MNSPE. The determination of trace PAHs in urine samples from smokers and nonsmokers was successfully carried out with this method, which implied that the versatile TCT MNPs and the robust method together represent a significant potential application in the analysis of body fluids and disease markers. Such methods for accurate quantification of trace components in water are very valuable as they fulfill an unmet need in environmental and medicinal chemistry.
authors.affiliation: College of Chemistry and Molecular Engineering, Zhengzhou University , Daxue Road 75, Zhengzhou, Henan 450052, PR China.
authors.forename: Wenfen
authors.initials: W
authors.lastname: Zhang
authors.affiliation: College of Chemistry and Molecular Engineering, Zhengzhou University , Daxue Road 75, Zhengzhou, Henan 450052, PR China.
authors.forename: Yanhao
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: College of Chemistry and Molecular Engineering, Zhengzhou University , Daxue Road 75, Zhengzhou, Henan 450052, PR China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Jiang
authors.affiliation: School of Chemistry and Chemical Engineering, Henan University of Technology , Zhengzhou, Henan 450001, PR China.
authors.forename: Wenjie
authors.initials: W
authors.lastname: Zhao
authors.affiliation: College of Chemistry and Molecular Engineering, Zhengzhou University , Daxue Road 75, Zhengzhou, Henan 450052, PR China.
authors.forename: Ajuan
authors.initials: A
authors.lastname: Yu
authors.affiliation: College of Chemistry and Molecular Engineering, Zhengzhou University , Daxue Road 75, Zhengzhou, Henan 450052, PR China.
authors.forename: Hong
authors.initials: H
authors.lastname: Chang
authors.affiliation: College of Chemistry and Molecular Engineering, Zhengzhou University , Daxue Road 75, Zhengzhou, Henan 450052, PR China.
authors.forename: Ximei
authors.initials: X
authors.lastname: Lu
authors.affiliation: Zhengzhou Tobacco Research Institute of CNTC , Zhengzhou, Henan 450001, PR China.
authors.forename: Fuwei
authors.initials: F
authors.lastname: Xie
authors.affiliation: College of Chemistry and Molecular Engineering, Zhengzhou University , Daxue Road 75, Zhengzhou, Henan 450052, PR China.
authors.forename: Baoxian
authors.initials: B
authors.lastname: Ye
authors.affiliation: College of Chemistry and Molecular Engineering, Zhengzhou University , Daxue Road 75, Zhengzhou, Henan 450052, PR China.
authors.forename: Shusheng
authors.initials: S
authors.lastname: Zhang