title: Increased risk for knee replacement surgery after arthroscopic surgery for degenerative meniscal tears: a multi-center longitudinal observational study using data from the osteoarthritis initiative.
abstract: The primary objective was to assess whether patients with knee osteoarthritis and whom undergo arthroscopic meniscectomy have an increased risk for future knee replacement surgery.
  
  
  
  Data used were obtained from the Osteoarthritis Initiative (OAI) study.
  
  
  
  Participants were enrolled, in four clinical centers, between February 2004 and May 2006 and were followed up on an annual basis up to and including 108-months from enrollment.
  
  
  
  4674 participants (58.4% female), aged 45-79, of all ethnic groups, who had, and those who were at high risk for developing, symptomatic knee osteoarthritis were included, of which 3337 (71.4%) were included in the final follow up visit.
  
  
  
  Hazard ratio of knee replacement surgery for participants who underwent arthroscopic meniscectomy during follow up compared to propensity score matched participants who did not undergo arthroscopic meniscectomy during follow up.
  
  
  
  335 participants underwent arthroscopic meniscectomy during follow up, of which 63 (18.8%) underwent knee replacement surgery in the same knee. Of the 335 propensity score matched participants 38 (11.1%) underwent knee replacement surgery during follow up. Results from the Cox-proportional hazards model demonstrated that the hazard ratio of knee replacement surgery was 3.03 (95% CI (1.67-5.26)) for participants who underwent arthroscopic meniscectomy relative to the propensity score matched participants who did not undergo arthroscopic meniscectomy.
  
  
  
  In patients with knee osteoarthritis arthroscopic knee surgery with meniscectomy is associated with a three fold increase in the risk for future knee replacement surgery.
authors.affiliation: Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Orthopaedic Research Lab, PO Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: Jan.Rongen@radboudumc.nl.
authors.forename: J J
authors.initials: JJ
authors.lastname: Rongen
authors.affiliation: Radboud University Medical Center, Radboud Institute for Health Sciences, Department for Health Evidence, PO Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: Maroeska.Rovers@radboudumc.nl.
authors.forename: M M
authors.initials: MM
authors.lastname: Rovers
authors.affiliation: Kliniek Viasana, PO Box 4, 5450 AA Mill, The Netherlands. Electronic address: tony.vantienen@radboudumc.nl.
authors.forename: T G
authors.initials: TG
authors.lastname: van Tienen
authors.affiliation: Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Orthopaedic Research Lab, PO Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: Pieter.buma@radboudumc.nl.
authors.forename: P
authors.initials: P
authors.lastname: Buma
authors.affiliation: Radboud University Medical Center, Radboud Institute for Health Sciences, Orthopaedic Research Lab, PO Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: Gerjon.Hannink@radboudumc.nl.
authors.forename: G
authors.initials: G
authors.lastname: Hannink
mesh_terms: D000368:Aged; D019645:Arthroplasty, Replacement, Knee / Q000706:statistics & numerical data*; D001182:Arthroscopy / Q000009:adverse effects* / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007718:Knee Injuries / Q000150:complications / Q000601:surgery*; D008137:Longitudinal Studies; D008297:Male; D000074403:Meniscectomy / Q000009:adverse effects / Q000706:statistics & numerical data; D000072600:Meniscus / Q000293:injuries* / Q000601:surgery; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000601:surgery; D012307:Risk Factors
keywords: Arthroplasty; Knee replacement; Meniscectomy; Meniscus; Osteoarthritis