title: Reference range of blood biomarkers for oxidative stress in Thoroughbred racehorses (2-5 years old).
abstract: The oxidant and antioxidant equilibrium is known to play an important role in equine medicine and equine exercise physiology. There are abundant findings in this field; however, not many studies have been conducted for reference ranges of oxidative stress biomarkers in horses. This study was conducted to determine the reference values of reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) using blood samples from 372 (191 males, 181 females) Thoroughbred racehorse aged 2 to 5 (3.43 ± 1.10 (mean ± SD)) years old. There were obvious gender differences in oxidative biomarkers, and growth/age-related changes were observed especially in females. Gender and age must be considered when interpreting obtained oxidative stress biomarkers for diagnosis of disease or fitness alterations in Thoroughbred racehorses.
authors.affiliation: Miho Training Center, Racehorse Hospital, Japan Racing Association, Ibaraki 300-0493, Japan.
authors.forename: Kanichi
authors.initials: K
authors.lastname: Kusano
authors.affiliation: Yamazaki Horse Clinic, Ibaraki 300-0415, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Yamazaki
authors.affiliation: Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 400-8510, Japan.
authors.forename: Masataka
authors.initials: M
authors.lastname: Kiuchi
authors.affiliation: Wismerll Company Limited, Tokyo 113-0033, Japan.
authors.forename: Kouki
authors.initials: K
authors.lastname: Kaneko
authors.affiliation: Graduate School Department of Interdisciplinary Research, University of Yamanashi, Yamanashi 400-8510, Japan.
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Koyama
keywords: Thoroughbred racehorse; oxidative stress biomarker; reference range