title: Mouse models of ageing and their relevance to disease.
abstract: Ageing is a process that gradually increases the organism's vulnerability to death. It affects different biological pathways, and the underlying cellular mechanisms are complex. In view of the growing disease burden of ageing populations, increasing efforts are being invested in understanding the pathways and mechanisms of ageing. We review some mouse models commonly used in studies on ageing, highlight the advantages and disadvantages of the different strategies, and discuss their relevance to disease susceptibility. In addition to addressing the genetics and phenotypic analysis of mice, we discuss examples of models of delayed or accelerated ageing and their modulation by caloric restriction.
authors.affiliation: University of Tartu, Tartu, Estonia and Estonian University of Life Sciences, Tartu, Estonia. Electronic address: sulev.koks@ut.ee.
authors.forename: Sulev
authors.initials: S
authors.lastname: Kõks
authors.affiliation: Yeditepe University, School of Medicine, Department of Medical Biology, Istanbul, Turkey. Electronic address: soner.dogan@yeditepe.edu.tr.
authors.forename: Soner
authors.initials: S
authors.lastname: Dogan
authors.affiliation: Yeditepe University, School of Medicine, Department of Biophysics, Istanbul, Turkey. Electronic address: bilge.tuna@yeditepe.edu.tr.
authors.forename: Bilge Guvenc
authors.initials: BG
authors.lastname: Tuna
authors.affiliation: Institute of Health Research-INCLIVA, 46010 Valencia, Spain and CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM), 28029 Madrid, Spain. Electronic address: herminia.gonzalez@uv.es.
authors.forename: Herminia
authors.initials: H
authors.lastname: González-Navarro
authors.affiliation: Mammalian Genetics Unit, MRC Harwell, Oxfordshire, UK. Electronic address: P.Potter@har.mrc.ac.uk.
authors.forename: Paul
authors.initials: P
authors.lastname: Potter
authors.affiliation: Inflammation Research Center, VIB, Ghent, Belgium, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium. Electronic address: Roosmarijn.Vandenbroucke@irc.VIB-UGent.be.
authors.forename: Roosmarijn E
authors.initials: RE
authors.lastname: Vandenbroucke
mesh_terms: D000375:Aging / Q000378:metabolism* / Q000473:pathology*; D000818:Animals; D006801:Humans; D051379:Mice; D008954:Models, Biological
keywords: Accelerated ageing; Ageing; Caloric restriction; Delayed ageing; Mouse models