title: DNA replication stress: a source of APOBEC3B expression in breast cancer.
abstract: APOBEC cytidine deaminases have been implicated as major contributors to the mutation burden in many cancers on the basis of their mutational signature. A new experimental study sheds light on the inciting factors, linking APOBEC3B expression to oncogene- and drug-induced replication stress.
authors.affiliation: Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. dave.cescon@uhn.ca.|Campbell Family Institute for Breast Cancer Research, Toronto, Canada. dave.cescon@uhn.ca.|Division of Medical Oncology and Hematology, Department of Medicine, University of Toronto, Toronto, Canada. dave.cescon@uhn.ca.
authors.forename: David W
authors.initials: DW
authors.lastname: Cescon
authors.affiliation: Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. bhaibeka@uhnresearch.ca.|Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. bhaibeka@uhnresearch.ca.|Department of Computer Science, University of Toronto, Toronto, ON, Canada. bhaibeka@uhnresearch.ca.|Ontario Institute of Cancer Research, Toronto, ON, Canada. bhaibeka@uhnresearch.ca.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Haibe-Kains
mesh_terms: D005260:Female; D006801:Humans; D001943:Breast Neoplasms / Q000209:etiology / Q000378:metabolism; D003564:Cytidine Deaminase / Q000235:genetics / Q000378:metabolism; D004261:DNA Replication; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D023281:Genomics; D015778:Minor Histocompatibility Antigens / Q000235:genetics / Q000378:metabolism; D005810:Multigene Family; D015398:Signal Transduction; D013312:Stress, Physiological
chemical_list: C495794:APOBEC3B protein, human; D003564:Cytidine Deaminase; D015778:Minor Histocompatibility Antigens