title: Plasmonic/Magnetic Multifunctional nanoplatform for Cancer Theranostics.
abstract: A multifunctional magneto-plasmonic CoFe2O4@Au core-shell nanoparticle was developed by iterative-seeding based method. This nanocargo consists of a cobalt ferrite kernel as a core (Nk) and multiple layers of gold as a functionalizable active stratum, (named as Nk@A after fifth iteration). Nk@A helps in augmenting the physiological stability and enhancing surface plasmon resonance (SPR) property. The targeted delivery of Doxorubicin using Nk@A as a nanopayload is demonstrated in this report. The drug release profile followed first order rate kinetics optimally at pH 5.4, which is considered as an endosomal pH of cells. The cellular MR imaging showed that Nk@A is an efficient T2contrast agent for both L6 (r2-118.08 mM-1s-1) and Hep2 (r2-217.24 mM-1s-1) cells. Microwave based magnetic hyperthermia studies exhibited an augmentation in the temperature due to the transformation of radiation energy into heat at 2.45 GHz. There was an enhancement in cancer cell cytotoxicity when hyperthermia combined with chemotherapy. Hence, this single nanoplatform can deliver 3-pronged theranostic applications viz., targeted drug-delivery, T2MR imaging and hyperthermia.
authors.affiliation: Program on Nanoscience and Nanotechnology, Av. 2508 National Polytechnic Institute, Gustavo A. Madero, San Pedro Zacatenco, 07360 Mexico City, Mexico.
authors.forename: M
authors.initials: M
authors.lastname: Ravichandran
authors.affiliation: Department of Genetics and Molecular Biology, Av. 2508 National Polytechnic Institute, Gustavo A. Madero, San Pedro Zacatenco, 07360 Mexico City, Mexico.
authors.forename: Goldie
authors.initials: G
authors.lastname: Oza
authors.affiliation: Department of Electrical Engineering, Av. 2508 National Polytechnic Institute, Gustavo A. Madero, San Pedro Zacatenco, 07360 Mexico City, Mexico.
authors.forename: S
authors.initials: S
authors.lastname: Velumani
authors.affiliation: Department of Genetics and Molecular Biology, Av. 2508 National Polytechnic Institute, Gustavo A. Madero, San Pedro Zacatenco, 07360 Mexico City, Mexico.
authors.forename: Jose Tapia
authors.initials: JT
authors.lastname: Ramirez
authors.affiliation: Department of Cell Biology, Av. 2508 National Polytechnic Institute, Gustavo A. Madero, San Pedro Zacatenco, 07360 Mexico City, Mexico.
authors.forename: Francisco
authors.initials: F
authors.lastname: Garcia-Sierra
authors.affiliation: Department of Cell Biology, Av. 2508 National Polytechnic Institute, Gustavo A. Madero, San Pedro Zacatenco, 07360 Mexico City, Mexico.
authors.forename: Norma Barragan
authors.initials: NB
authors.lastname: Andrade
authors.affiliation: Department of Electrical Engineering - Bioelectronics Section, CINVESTAV-IPN, Av. 2508 National Polytechnic Institute, Gustavo A. Madero, San Pedro Zacatenco, 07360 Mexico City.
authors.forename: A
authors.initials: A
authors.lastname: Vera
authors.affiliation: Department of Electrical Engineering - Bioelectronics Section, CINVESTAV-IPN, Av. 2508 National Polytechnic Institute, Gustavo A. Madero, San Pedro Zacatenco, 07360 Mexico City.
authors.forename: L
authors.initials: L
authors.lastname: Leija
authors.affiliation: Department of Mechanical and Electrical Engineering, Universidad Autonoma de Nuevo Leon, San Nicolás de Los Garza, Nuevo León, 66451 Mexico City, Mexico.
authors.forename: Marco A
authors.initials: MA
authors.lastname: Garza-Navarro
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000493:pharmacokinetics; D003035:Cobalt / Q000737:chemistry; D003287:Contrast Media / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods; D065546:Drug Liberation; D005290:Ferric Compounds / Q000138:chemical synthesis / Q000737:chemistry; D005492:Folic Acid / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D008279:Magnetic Resonance Imaging; D008280:Magnetics / Q000379:methods; D053768:Metal Nanoparticles / Q000008:administration & dosage*; D046529:Microscopy, Electron, Transmission; D008872:Microwaves; D000068936:Theranostic Nanomedicine / Q000295:instrumentation / Q000379:methods*; D014961:X-Ray Diffraction
chemical_list: D000903:Antibiotics, Antineoplastic; D003287:Contrast Media; D005290:Ferric Compounds; C569492:cobalt ferrite; D003035:Cobalt; D006046:Gold; D004317:Doxorubicin; D005492:Folic Acid