title: Antileukemic α-pyrone derivatives from the endophytic fungusAlternaria phragmospora.
abstract: Four new (1-4) and two known (5and6) α-pyrone derivatives have been isolated fromAlternaria phragmospora, an endophytic fungus fromVinca rosea, leaves. The isolated compounds were chemically identified to be 5-butyl-4-methoxy-6-methyl-2H-pyran-2-one (1), 5-butyl-6-(hydroxymethyl)-4-methoxy-2H-pyran-2-one (2), 5-(1-hydroxybutyl)-4-methoxy-6-methyl-2H-pyran-2-one (3), 4-methoxy-6-methyl-5-(3-oxobutyl)-2H-pyran-2-one (4), 5-(2-hydroxyethyl)-4-methoxy-6-methyl-2H-pyran-2-one (5), and 5-[(2E)-but-2-en-1-yl]-4-methoxy-6-methyl-2H-pyran-2-one (6). Compounds2and4showed moderate antileukemic activities against HL60 cells with IC50values of 2.2 and 0.9 μM and against K562 cells with IC50values of 4.5 and 1.5 μM, respectively.
authors.affiliation: National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA; Department of Pharmacognosy, Faculty of Pharmacy, University of Al-Azhar, Cairo, Egypt.
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Metwaly
authors.affiliation: Department of Chemistry, College of Science, Louisiana State University, Baton Rouge, LA 70803, USA.
authors.forename: Frank R
authors.initials: FR
authors.lastname: Fronczek
authors.affiliation: National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
authors.forename: Guoyi
authors.initials: G
authors.lastname: Ma
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, University of Al-Azhar, Cairo, Egypt.
authors.forename: Hazem A
authors.initials: HA
authors.lastname: Kadry
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, University of Al-Azhar, Cairo, Egypt.
authors.forename: Atef A
authors.initials: AA
authors.lastname: El-Hela
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, University of Al-Azhar, Cairo, Egypt.
authors.forename: Abd-Elsalam I
authors.initials: AI
authors.lastname: Mohammad
authors.affiliation: National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA; Department of Medicinal Chemistry, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Cutler
authors.affiliation: National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA; Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
authors.forename: Samir A
authors.initials: SA
authors.lastname: Ross
keywords: Alternaria phragmospora; Antileukemic; Endophytic fungi; α-Pyrone derivatives