title: The association between Self-Reported Medication Adherence scores and systolic blood pressure control: a SPRINT baseline data study.
abstract: We examined baseline data from the Systolic Blood Pressure Intervention Trial (SPRINT) to investigate whether medication adherence, measured by the 8-item Morisky Medication Adherence Scale (MMAS-8), was associated with systolic blood pressure (SBP) and whether MMAS-8 score and number of antihypertensive medications interacted in influencing SBP. A total of 8435 SPRINT participants were included: 21.2% had low adherence (MMAS-8: <6); 40.0% had medium adherence (6 to <8); and 38.8% had high adherence (8). SBP was <140 mm Hg in 54.6%; 140-160 mm Hg in 36.6%; and >160 mm Hg in 8.8%. In multivariable regression, medium vs. low adherence weakly associated with lower SBP (odds ratio: 1.17; confidence interval: 1.04, 1.31). SPRINT eligibility criteria should be considered when interpreting results. Efforts to understand and enhance adherence are crucial to improve population health, and using self-report instruments might be considered for predicting treatment adherence and response in future efficacy trials and for identifying patients for adherence support in clinical practice.
authors.affiliation: Mayo Clinic, Jacksonville, FL, USA. Electronic address: haley.william@mayo.edu.
authors.forename: William E
authors.initials: WE
authors.lastname: Haley
authors.affiliation: Section on Cardiovascular Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
authors.forename: Olivia N
authors.initials: ON
authors.lastname: Gilbert
authors.affiliation: Division of Cardiology, University of Washington, Seattle, WA, USA.
authors.forename: Robert F
authors.initials: RF
authors.lastname: Riley
authors.affiliation: Medical University of South Carolina, Charleston, SC, USA.
authors.forename: Jill C
authors.initials: JC
authors.lastname: Newman
authors.affiliation: VA Tennessee Valley Healthcare System Geriatric Research and Education Clinical Center Nashville and Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Christianne L
authors.initials: CL
authors.lastname: Roumie
authors.affiliation: Milwaukee VA Medical Center, Milwaukee, WI, USA.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Whittle
authors.affiliation: Columbia University Medical Center, New York, NY, USA.
authors.forename: Ian M
authors.initials: IM
authors.lastname: Kronish
authors.affiliation: Miami Veterans Affairs and University of Miami Health System, Miami, FL, USA.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Tamariz
authors.affiliation: University Hospitals, Cleveland, OH, USA.
authors.forename: Alan
authors.initials: A
authors.lastname: Wiggers
authors.affiliation: UCLA School of Public Health, Los Angeles, CA, USA.
authors.forename: Donald E
authors.initials: DE
authors.lastname: Morisky
authors.affiliation: Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
authors.forename: Molly B
authors.initials: MB
authors.lastname: Conroy
authors.affiliation: Duke University Medical Center, Durham, NC, USA.
authors.forename: Eugene
authors.initials: E
authors.lastname: Kovalik
authors.affiliation: Department of Veterans Affairs, Boston University School of Medicine, Boston, MA, USA.
authors.forename: Nancy R
authors.initials: NR
authors.lastname: Kressin
authors.affiliation: University of Alabama School of Public Health, Birmingham, AL, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Muntner
authors.affiliation: Colorado School of Public Health, Denver, CO, USA.
authors.forename: David C
authors.initials: DC
authors.lastname: Goff
mesh_terms: D000367:Age Factors; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D057566:Self Report; D012737:Sex Factors; D013599:Systole; D016903:Drug Monitoring
chemical_list: D000959:Antihypertensive Agents
keywords: Clinical trial; MMAS-8; hypertension