title: Retrospective evaluation of blood copper stable isotopes ratio65Cu/63Cu as a biomarker of cancer in dogs.
abstract: Previous studies in humans with breast, colorectal or liver cancer showed that neoplasia was associated with a modification of the blood ratio between65Cu and63Cu (∂Cu). The aim of the present study was to compare the blood ∂Cu of dogs with cancer to healthy controls or dogs with non-oncologic disease. One hundred and seventeen dogs were included in the study (35 dogs with cancer, 33 dogs with non-neoplastic disease, and 49 healthy controls). The ∂Cu of dogs with cancer was significantly lower than the ratio of healthy controls (P < 0.0001) but not significantly different from dogs with non-oncologic disease. Six dogs with lymphoma were also evaluated after they achieved clinical remission and five out of six had an increase of ∂Cu. Further studies are warranted but these results suggest that ∂Cu could help in the diagnosis of cancer in a controlled clinical context, and may be a potential biomarker for the follow-up of cancer.
authors.affiliation: Clinical Unit of Oncology, Department of Internal Medicine, University of Lyon, Lyon, France.
authors.forename: G
authors.initials: G
authors.lastname: Chamel
authors.affiliation: ISTerre, Grenoble Alpes University, Grenoble, France.
authors.forename: A T
authors.initials: AT
authors.lastname: Gourlan
authors.affiliation: Univ Lyon, ENS-Lyon, Université Lyon, Lyon, France.
authors.forename: P
authors.initials: P
authors.lastname: Télouk
authors.affiliation: Clinical Unit of Oncology, Department of Internal Medicine, University of Lyon, Lyon, France.
authors.forename: D
authors.initials: D
authors.lastname: Sayag
authors.affiliation: CRB-ANIM, UPSP ICE 2011-03-101, University of Lyon, Lyon, France.
authors.forename: V
authors.initials: V
authors.lastname: Milliard
authors.affiliation: CRB-ANIM, UPSP ICE 2011-03-101, University of Lyon, Lyon, France.
authors.forename: C
authors.initials: C
authors.lastname: Loiseau
authors.affiliation: Univ Lyon, ENS-Lyon, Université Lyon, Lyon, France.
authors.forename: M
authors.initials: M
authors.lastname: Simon
authors.affiliation: CRB-ANIM, UPSP ICE 2011-03-101, University of Lyon, Lyon, France.|Department of Theriogenology, CERREC, University of Lyon, Lyon, France.
authors.forename: S
authors.initials: S
authors.lastname: Buff
authors.affiliation: Clinical Unit of Oncology, Department of Internal Medicine, University of Lyon, Lyon, France.|CRB-ANIM, UPSP ICE 2011-03-101, University of Lyon, Lyon, France.
authors.forename: F
authors.initials: F
authors.lastname: Ponce
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000097:blood; D003300:Copper / Q000097:blood*; D003301:Copper Radioisotopes / Q000097:blood*; D004283:Dog Diseases / Q000097:blood* / Q000175:diagnosis; D004285:Dogs; D005260:Female; D008297:Male; D013058:Mass Spectrometry / Q000662:veterinary; D009369:Neoplasms / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; D003301:Copper Radioisotopes; D003300:Copper
keywords: biomarker; cancer; copper; dog; lymphoma; mass spectrometry