title: Clinical Characteristics of Aspirin-Exacerbated Respiratory Disease.
abstract: Aspirin-exacerbated respiratory disease is a significant endotype of both asthma and chronic rhinosinusitis with nasal polyps. The disease demonstrates what seems to be a unified inflammatory mechanism culminating in highly eosinophilic nasal polyp disease and asthma. The rate of polyp recurrence and morbidity from asthma exacerbations are significant and warrant separating this group diagnostically from aspirin-tolerant peers. Given the unique anti-inflammatory effects of aspirin and the evolving landscape of new, targeted biologic treatments, it is even more incumbent to consider this diagnosis and offer patients treatment specific for the disease.
authors.affiliation: Scripps Clinic, Division of Allergy, Asthma and Immunology, 3811 Valley Centre Drive S99, San Diego, CA 92130, USA.
authors.forename: Donald D
authors.initials: DD
authors.lastname: Stevenson
authors.affiliation: Scripps Clinic, Division of Allergy, Asthma and Immunology, 3811 Valley Centre Drive S99, San Diego, CA 92130, USA. Electronic address: white.andrew@scrippshealth.org.
authors.forename: Andrew A
authors.initials: AA
authors.lastname: White
mesh_terms: D000438:Alcohols / Q000009:adverse effects; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D015897:Comorbidity; D003429:Cross Reactions / Q000276:immunology; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects; D006801:Humans; D010641:Phenotype; D015995:Prevalence; D012140:Respiratory Tract Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D012720:Severity of Illness Index; D063189:Symptom Assessment
chemical_list: D000438:Alcohols; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D001241:Aspirin
keywords: Aspirin; Asthma; Chronic rhinosinusitis; Cyclooxygenase 1; Nasal polyposis; Nonsteroidal anti-inflammatory drugs; Quality of life