title: Levels of the soluble LDL receptor-relative LR11 decrease in overweight individuals with type 2 diabetes upon diet-induced weight loss.
abstract: Cardiovascular disease (CVD) is a major complication in patients with type 2 diabetes (T2D), especially in those with obesity. Plasma soluble low density lipoprotein receptor-relative with 11 ligand-binding repeats (sLR11) plays a role in the development of atherosclerosis and has been linked to the metabolism of triglyceride-rich lipoproteins, adiposity, and vascular complications in T2D. We aimed to determine the effect of diet-induced weight loss on plasma sLR11 levels in overweight and obese individuals with T2D.
  
  
  
  Plasma sLR11 levels were determined in 64 individuals with T2D and BMI >27 kg/m2before and after a 20-week weight loss diet. As a reference, sLR11 levels were also determined in 64 healthy, non-obese controls, matched as a group for age and sex.
  
  
  
  Median plasma sLR11 levels of the T2D study-group at baseline (15.4 ng/mL (IQR 12.9-19.5)) were higher than in controls (10.2 (IQR: 8.7-12.2) ng/mL; p = 0.001). The diet resulted in a weight loss of 9.7 ± 5.2% (p = 0.001) and improved CVD risk factors. sLR11 levels were reduced to 13.3 ng/mL (IQR 11.0-17.1; p = 0.001). Changes in sLR11 levels positively associated with changes in non-HDL cholesterol (B = 1.54, R2= 0.17, p = 0.001) and HbA1c (B = 0.07, R2= 0.11, p = 0.007), but not with weight loss (B = 0.04, R2= 0.05, p = 0.076). The changes in non-HDL cholesterol and HbA1c together explained 24% of the variance of sLR11 reduction (p = 0.001).
  
  
  
  Weight loss dieting in overweight and obese individuals with T2D resulted in a reduction in plasma sLR11 levels that was associated with improvements in lipid-profile and glycemic state.
authors.affiliation: Department of Internal Medicine, Section Pharmacology Vascular and Metabolic Diseases, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Psychiatry, Unit of Medical Psychology and Psychotherapy, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Kirsten A
authors.initials: KA
authors.lastname: Berk
authors.affiliation: Department of Internal Medicine, Section Pharmacology Vascular and Metabolic Diseases, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Ranitha
authors.initials: R
authors.lastname: Vongpromek
authors.affiliation: Department of Clinical-Laboratory and Experimental-Research Medicine, Toho University, Sakura Medical Center, Sakura, Japan.
authors.forename: Meizi
authors.initials: M
authors.lastname: Jiang
authors.affiliation: Department of Medical Biochemistry, Medical University of Vienna, Max. F. Perutz Laboratories, Vienna, Austria.
authors.forename: Wolfgang J
authors.initials: WJ
authors.lastname: Schneider
authors.affiliation: Department of Psychiatry, Unit of Medical Psychology and Psychotherapy, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Reinier
authors.initials: R
authors.lastname: Timman
authors.affiliation: Department of Internal Medicine, Section Pharmacology Vascular and Metabolic Diseases, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Adrie J M
authors.initials: AJ
authors.lastname: Verhoeven
authors.affiliation: Department of Clinical-Laboratory and Experimental-Research Medicine, Toho University, Sakura Medical Center, Sakura, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Bujo
authors.affiliation: Department of Internal Medicine, Section Pharmacology Vascular and Metabolic Diseases, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Eric J G
authors.initials: EJ
authors.lastname: Sijbrands
authors.affiliation: Department of Internal Medicine, Section Pharmacology Vascular and Metabolic Diseases, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: m.t.mulder@erasmusmc.nl.
authors.forename: Monique T
authors.initials: MT
authors.lastname: Mulder
mesh_terms: D002318:Cardiovascular Diseases / Q000097:blood* / Q000150:complications; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D004032:Diet; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D026502:LDL-Receptor Related Proteins / Q000097:blood*; D008074:Lipoproteins; D008297:Male; D026901:Membrane Transport Proteins / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications; D050177:Overweight / Q000097:blood* / Q000150:complications; D014280:Triglycerides / Q000097:blood; D015431:Weight Loss
chemical_list: D006442:Glycated Hemoglobin; D026502:LDL-Receptor Related Proteins; D008074:Lipoproteins; D026901:Membrane Transport Proteins; D014280:Triglycerides; C102582:SORL1 protein, human; C517652:hemoglobin A1c protein, human; C030087:lipoprotein triglyceride
keywords: Cardiovascular disease risk factors; Diet; Obesity; Soluble LR11; Type 2 diabetes mellitus; Weight loss