title: The role of haematological parameters in predicting malaria with special emphasis on neutrophil lymphocyte count ratio and monocyte lymphocyte ratio: A single Institutional experience.
abstract: BACKGROUND
  Malaria is a mosquito borne disease which is a major public health problem and a leading cause of morbidity and mortality worldwide. Various haematological parameters have been studied to help predict malaria, such as alteration in the leucocyte count, platelet counts and erythrocyte counts. The neutrophil lymphocyte count ratio (NLCR) was found to have a good predictive value in systemic inflammation, particularly in critical care setting.
  
  
  OBJECTIVE
  The present study aims to study the various haematological parameters and acertain the predictive value of NLCR and MLR in the detection of malaria.
  
  
  METHODS
  A prospective cross sectional study was conducted at a tertiary care hospital between the period of August to December, 2014. A total of 200 smear positive malaria patients and a control group of 100 patients who were smear negative for malaria were included. Hemoglobin, Total leucocyte count, Differential leucocyte count, platelet counts and absolute counts were obtained. The NLCR and MLR were obtained from the above data. The data was analysed by statistical tools.
  
  
  RESULTS
  A total of 200 smear positive malaria cases were analysed of which, 180 cases were caused by the Plasmodium vivax parasite and 2 cases by Plasmodium Falciparum. Thrombocytopenia and leucopenia were found to have significant association with malaria. In the present study, the NLCR and MLR was not found to have significant association with malaria.
  
  
  CONCLUSIONS
  Although NLCR has been proven to be a useful marker for inflammation in many acute conditions5, it is albeit not of much significance in the prediction of malaria. Similarly we have found no significance of MLR in prediction of malaria.
authors.affiliation: Department of Pathology, Father Muller Medical College, Mangalore, Karnataka, India.
authors.forename: Cheryl Sarah
authors.initials: CS
authors.lastname: Philipose
authors.affiliation: Department of Pathology, Father Muller Medical College, Mangalore, Karnataka, India.
authors.forename: T
authors.initials: T
authors.lastname: Umashankar
keywords: Malaria; monocyte lymphocyte ratio; neutrophil lymphocyte count ratio