title: Chemoselective reductive alkynylation of tertiary amides by Ir and Cu(i) bis-metal sequential catalysis.
abstract: We report herein a convenient and versatile method for the direct reductive alkynylation of tertiary amides to give propargylic amines through sequential Ir-catalysed hydrosilylation-Cu(i)-catalysed alkynylation. The reactions proceed chemoselectively at the amide group in the presence of several sensitive functional groups including the very reactive aldehyde group on either the amide or the alkyne coupling partner. The method is general for tert-amides with or without α-hydrogen.
authors.affiliation: Department of Chemistry and The Key Laboratory for Chemical Biology of Fujian Province, iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, P. R. China. pqhuang@xmu.edu.cn and State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China.
authors.forename: Pei-Qiang
authors.identifier: http://orcid.org/0000-0003-3230-0457
authors.initials: PQ
authors.lastname: Huang
authors.affiliation: Department of Chemistry and The Key Laboratory for Chemical Biology of Fujian Province, iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, P. R. China. pqhuang@xmu.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Ou
authors.affiliation: Department of Chemistry and The Key Laboratory for Chemical Biology of Fujian Province, iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, P. R. China. pqhuang@xmu.edu.cn.
authors.forename: Feng
authors.initials: F
authors.lastname: Han