title: Protective effect of wild Corni fructus methanolic extract against acute alcoholic liver injury in mice.
abstract: BACKGROUND
  In Chinese folk medicine, Corni fructus (C. fructus) has traditionally been used to improve liver function, although the mechanism underlying its activity remains unclear. The aim of the present study was to evaluate the protective effects of wild C. fructus methanolic extract against acute alcoholic liver injury.
  
  
  METHODS
  Alcohol was administered to mice for three consecutive days, either alone or in combination with C. fructus methanolic extract (50, 100, or 200 mg/kg body weight/d). Serum and liver tissue were collected from the animals and subjected to biochemical and histopathological analyses.
  
  
  RESULTS
  C. fructus signiﬁcantly alleviated alcohol-induced liver injury by reducing serum alanine aminotransferase, aspartate aminotransferase, and thiobarbituric acid reactive species, inhibiting hydroxyl radicals (•OH), and increasing total superoxide dismutase, glutathione peroxidase, and glutathione in the liver (P < 0.05). In addition, the C. fructus treatment inhibited the expression and activity of cytochrome P450 2E1 (P < 0.05).
  
  
  CONCLUSIONS
  C. fructus could be a promising natural substance for ameliorating acute alcohol-induced oxidative stress and hepatic injury.
authors.affiliation: a College of Veterinary Medicine, Northwest A&F University , Yangling , Shaanxi , China.|b Chinese-German Joint Laboratory for Natural Product Research, Qinling-Bashan Mountains Bioresources Comprehensive Development C.I.C., College of Biological Science and Engineering, Shaanxi Sci-Tech University , Hanzhong , Shaanxi , China.
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: a College of Veterinary Medicine, Northwest A&F University , Yangling , Shaanxi , China.|b Chinese-German Joint Laboratory for Natural Product Research, Qinling-Bashan Mountains Bioresources Comprehensive Development C.I.C., College of Biological Science and Engineering, Shaanxi Sci-Tech University , Hanzhong , Shaanxi , China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: c College of Veterinary Medicine, Xinjiang Agriculture University , Xinjiang , China.
authors.forename: Huiting
authors.initials: H
authors.lastname: Xue
authors.affiliation: a College of Veterinary Medicine, Northwest A&F University , Yangling , Shaanxi , China.
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.affiliation: b Chinese-German Joint Laboratory for Natural Product Research, Qinling-Bashan Mountains Bioresources Comprehensive Development C.I.C., College of Biological Science and Engineering, Shaanxi Sci-Tech University , Hanzhong , Shaanxi , China.
authors.forename: Hai
authors.initials: H
authors.lastname: Jiang
authors.affiliation: b Chinese-German Joint Laboratory for Natural Product Research, Qinling-Bashan Mountains Bioresources Comprehensive Development C.I.C., College of Biological Science and Engineering, Shaanxi Sci-Tech University , Hanzhong , Shaanxi , China.
authors.forename: Yinku
authors.initials: Y
authors.lastname: Liang
authors.affiliation: b Chinese-German Joint Laboratory for Natural Product Research, Qinling-Bashan Mountains Bioresources Comprehensive Development C.I.C., College of Biological Science and Engineering, Shaanxi Sci-Tech University , Hanzhong , Shaanxi , China.|d Centre for the Research and Technology of Agro-Environment and Biological Sciences (CITAB-UM), AgroBioPlant Group, Department of Biology , University of Minho , Braga , Portugal.
authors.forename: Alberto C
authors.initials: AC
authors.lastname: Dias
authors.affiliation: b Chinese-German Joint Laboratory for Natural Product Research, Qinling-Bashan Mountains Bioresources Comprehensive Development C.I.C., College of Biological Science and Engineering, Shaanxi Sci-Tech University , Hanzhong , Shaanxi , China.
authors.forename: Marslin
authors.initials: M
authors.lastname: Gregory
authors.affiliation: b Chinese-German Joint Laboratory for Natural Product Research, Qinling-Bashan Mountains Bioresources Comprehensive Development C.I.C., College of Biological Science and Engineering, Shaanxi Sci-Tech University , Hanzhong , Shaanxi , China.
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.affiliation: a College of Veterinary Medicine, Northwest A&F University , Yangling , Shaanxi , China.|b Chinese-German Joint Laboratory for Natural Product Research, Qinling-Bashan Mountains Bioresources Comprehensive Development C.I.C., College of Biological Science and Engineering, Shaanxi Sci-Tech University , Hanzhong , Shaanxi , China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D029768:Cornus / Q000737:chemistry*; D019392:Cytochrome P-450 CYP2E1 / Q000378:metabolism; D005260:Female; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000293:injuries / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D000432:Methanol / Q000737:chemistry*; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000627:therapeutic use*; D013482:Superoxide Dismutase
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D019392:Cytochrome P-450 CYP2E1; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005978:Glutathione; D000432:Methanol
keywords: CYP2E1; Corni fructus; acute alcoholic liver; hepatoprotective drug; hepatotoxicity; mice; oxidative stress; traditional Chinese medicine