title: Oxycodone versus dezocine for postoperative analgesia in patients with cervical cancer treated with radical surgery.
abstract: OBJECTIVE
  The aim of this study was to evaluate oxycodone versus dezocine for postoperative analgesia in patients with cervical cancer treated with radical surgery.
  
  
  METHODS
  Fifty-one cases of cervical cancer treated with radical surgery were included in the present study and divided into oxycodone group (n = 26) and dezocine group (n = 25). Patients in the oxycodone group were given with oxycodone 1 mg/kg plus tropisetron 0.1 mg/kg diluting to 100 ml by 0.9% saline for patient-controlled intravenous analgesia (PCIA) after surgery. Moreover, patients in the dezocine group were given with dezocine 0.6 mg/kg plus tropisetron 0.1 mg/kg diluting to 100 ml by 0.9% saline for PCIA after surgery. The visual analog scale (VAS) and Ramsay sedation score of the two groups were recorded in the time point of 4, 8, 12, 24, and 48 h after surgery. The adverse event-related drugs were recorded and compared between the two groups.
  
  
  RESULTS
  The VAS score was significantly lower in oxycodone group compared to dezocine group in the time point of 4, 8, 12, 24, and 48 h (Pall < 0.05). The Ramsay score at time point of 4, 8, 12, 24 h, and 48 h were obviously higher in oxycodone group than those in dezocine group (P < 0.05) which indicated that the sedative effect in oxycodone group was superior to dezocine. For oxycodone group, there were six cases (23.08%) with nausea and one case (3.85) with vomiting in the treatment procedure. Moreover, for dezocine group, there were one case (4.00%) with nausea, two cases (8.00%) with vomiting, and two cases (8.00%) with dizzy in the treatment procedure. There was no statistical difference of adverse event risk between the two groups (P > 0.05).
  
  
  CONCLUSIONS
  Oxycodone postoperative analgesia is superior to dezocine for patients with cervical cancer treated with radical surgery.
authors.affiliation: Department of Anesthesiology, Lishui People's Hospital, Lishui, Zhejiang 323000, PR China.
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Gynaecology and Obstetrics, Lishui People's Hospital, Lishui, Zhejiang 323000, PR China.
authors.forename: Honglian
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Anesthesiology, Lishui People's Hospital, Lishui, Zhejiang 323000, PR China.
authors.forename: Renhong
authors.initials: R
authors.lastname: He
authors.affiliation: Department of Gynaecology and Obstetrics, Lishui People's Hospital, Lishui, Zhejiang 323000, PR China.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Gynaecology and Obstetrics, Lishui People's Hospital, Lishui, Zhejiang 323000, PR China.
authors.forename: Shaoxiao
authors.initials: S
authors.lastname: Liu
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D010098:Oxycodone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000175:diagnosis / Q000188:drug therapy*; D013764:Tetrahydronaphthalenes / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000150:complications* / Q000601:surgery
chemical_list: D000701:Analgesics, Opioid; D019086:Bridged Bicyclo Compounds, Heterocyclic; D013764:Tetrahydronaphthalenes; D010098:Oxycodone; C010827:dezocine