title: Chemotherapy dosing in achondroplastic dwarfism: a case report and review of literature.
abstract: OBJECTIVE
  CASE DESCRIPTION: A 74-year-old female with achondroplastic dwarfism was diagnosed with ER-, BR- and HER2- breast cancer. No guideline currently exists to direct chemotherapy dosing in this population. She received neoadjuvant chemotherapy based on body surface area utilizing actual height and weight with dose-dense doxorubicin and cyclophosphamide followed by paclitaxel with the use of granulocyte colony-stimulating factor. Satisfactory clinical response and remission were achieved, and treatment proceeded without any significant toxicity or delays.
  
  
  CONCLUSIONS
  In the absence of guideline recommendations, dosing chemotherapy based on actual height and weight in patients with achondroplastic dwarfism may be safe and appropriate.
authors.affiliation: Appalachian Regional Healthcare, Hematology/Oncology Clinic, Hazard, KY, USA.
authors.forename: R
authors.initials: R
authors.lastname: Elsoueidi
authors.affiliation: School of Pharmacy, Marshall University, Huntington, WV, USA.
authors.forename: C
authors.initials: C
authors.lastname: Gresham
authors.affiliation: Pharmacy Department, Huntington VA Medical Center, Huntington, WV, USA.
authors.forename: L
authors.initials: L
authors.lastname: Michael
authors.affiliation: R X Discount Pharmacy, Hazard, KY, USA.
authors.forename: D
authors.initials: D
authors.lastname: Chaney
authors.affiliation: Pharmacy Department, Mayo Clinic, Jacksonville, FL, USA. Mourad.hesham@mayo.edu.
authors.forename: H
authors.identifier: http://orcid.org/0000-0002-5611-3261
authors.initials: H
authors.lastname: Mourad
mesh_terms: D000130:Achondroplasia / Q000473:pathology*; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D020360:Neoadjuvant Therapy / Q000379:methods; D017239:Paclitaxel / Q000008:administration & dosage
chemical_list: D004317:Doxorubicin; D003520:Cyclophosphamide; D017239:Paclitaxel
keywords: achondroplastic dwarfism; body surface area dosing; breast cancer; chemotherapy; cyclophosphamide; doxorubicin; paclitaxel