title: Bone mineral density is associated with left ventricular diastolic function in women.
abstract: BACKGROUND
  Low bone mineral density (BMD) and left ventricular (LV) diastolic function are associated with heart failure. However, little is known about the association between BMD and LV diastolic function.
  
  
  OBJECTIVE
  BMD is independently related to LV diastolic function in women.
  
  
  METHODS
  We conducted a cross-sectional study of 432 women. Brachial-ankle pulse wave velocity (baPWV) and BMD measurements were performed. LV diastolic function and structure were assessed by echocardiographic examination.
  
  
  RESULTS
  BaPWV and the percentage of LV diastolic dysfunction increased with progressive bone loss. Moreover, partial correlation analysis demonstrated that BMD at spine L2-4 and at femoral neck were correlated with baPWV and LV diastolic function parameters after adjusting covariates. Multivariate logistic regression analysis revealed that osteoporosis was independently associated with LV diastolic dysfunction in women.
  
  
  CONCLUSIONS
  Osteoporosis is independently associated with LV diastolic dysfunction in women. A prospective study is needed to elucidate the effects of BMD on cardiac function in women.
authors.affiliation: Department of Internal Medicine, Third Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.
authors.forename: Rui-Tao
authors.initials: RT
authors.lastname: Wang
authors.affiliation: Department of Orthopedics, First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.
authors.forename: Xue-Song
authors.initials: XS
authors.lastname: Li
authors.affiliation: Department of Geriatrics, Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.
authors.forename: Ji-Rong
authors.initials: JR
authors.lastname: Zhang
authors.affiliation: Children's Nutrition Research Center, Huffington Center on Aging, Departments of Pediatrics & Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.
authors.forename: Yuxiang
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Intensive Care, Third Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.
authors.forename: Kai-Jiang
authors.initials: KJ
authors.lastname: Yu
authors.affiliation: Division of Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas.
authors.forename: Tiemin
authors.initials: T
authors.lastname: Liu
mesh_terms: D000368:Aged; D015519:Bone Density; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003971:Diastole; D004452:Echocardiography; D005260:Female; D006801:Humans; D015994:Incidence; D010024:Osteoporosis / Q000150:complications* / Q000175:diagnosis; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D018487:Ventricular Dysfunction, Left / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*; D016277:Ventricular Function, Left / Q000502:physiology*
keywords: Imaging; echocardiography