title: Synthesizing a nano-composite of BSA-capped Au nanoclusters/graphitic carbon nitride nanosheets as a new fluorescent probe for dopamine detection.
abstract: A strong red fluorescent nanocomposite, consisting of graphite-like carbon nitride nanosheets (g-C3N4NSs) and serum albumin-capped Au nanoclusters (AuNCs), was synthesized. Dopamine (DA) can quench the red fluorescence of the nanocomposite, based on the Forster resonance energy transfer (FRET) mechanism. In this quenching process, the energy is transferred from the fluorescent g-C3N4NSs-AuNCs to the oxidized DA quinine molecules (DA is easily oxidated to form DA quinine in air). The red fluorescence emission at 420 nm decreases dramatically and the quenching ratio (F0- F)/F0is linearly related to the concentration of DA in the range of 0.05-8.0 μmol L-1with a detection limit of 0.018 μmol L-1(S/N = 3). Additionally, this sensor has a potential of application to assay the DA in the real samples, such as human serum and human urine.
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, 330047, China; School of Chemistry, Nanchang University, Nanchang, 330031, China.
authors.forename: Xinrong
authors.initials: X
authors.lastname: Guo
authors.affiliation: School of Chemistry, Nanchang University, Nanchang, 330031, China.
authors.forename: Fangying
authors.initials: F
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, 330047, China. Electronic address: ynni@ncu.edu.cn.
authors.forename: Yongnian
authors.initials: Y
authors.lastname: Ni
authors.affiliation: School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, 4001, Australia.
authors.forename: Serge
authors.initials: S
authors.lastname: Kokot
mesh_terms: D004298:Dopamine / Q000032:analysis* / Q000097:blood / Q000652:urine; D005456:Fluorescent Dyes / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006801:Humans; D057230:Limit of Detection; D053768:Metal Nanoparticles / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D053761:Nanocomposites / Q000737:chemistry*; D009570:Nitriles / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D013057:Spectrum Analysis / Q000379:methods; D014961:X-Ray Diffraction
chemical_list: D005456:Fluorescent Dyes; D009570:Nitriles; D012710:Serum Albumin, Bovine; C011206:cyanogen; D006046:Gold; D004298:Dopamine
keywords: Au nanoclusters; Dopamine; Forster resonance energy transfer; Graphite-like carbon nitride nanosheets