title: Renal drug transporters and their significance in drug-drug interactions.
abstract: The kidney is a vital organ for the elimination of therapeutic drugs and their metabolites. Renal drug transporters, which are primarily located in the renal proximal tubules, play an important role in tubular secretion and reabsorption of drug molecules in the kidney. Tubular secretion is characterized by high clearance capacities, broad substrate specificities, and distinct charge selectivity for organic cations and anions. In the past two decades, substantial progress has been made in understanding the roles of transporters in drug disposition, efficacy, toxicity and drug-drug interactions (DDIs). In the kidney, several transporters are involved in renal handling of organic cation (OC) and organic anion (OA) drugs. These transporters are increasingly recognized as the target for clinically significant DDIs. This review focuses on the functional characteristics of major human renal drug transporters and their involvement in clinically significant DDIs.
authors.affiliation: Department of Pharmaceutics, University of Washington, Seattle, WA 98195-7610, USA.
authors.forename: Jia
authors.initials: J
authors.lastname: Yin
authors.affiliation: Department of Pharmaceutics, University of Washington, Seattle, WA 98195-7610, USA.
authors.forename: Joanne
authors.initials: J
authors.lastname: Wang
keywords: ABC, ATP-binding cassette; ATP, adenosine triphosphate; AUC, area under the plasma concentration curve; BBB, blood–brain barrier; CHO, Chinese hamster ovary; CL, plasma clearance; CLR, renal clearance; Cmax, maximum plasma concentration; DDIs, drug–drug interactions; Drug–drug interactions; FDA, U.S. Food and Drug Administration; GSH, glutathione; HEK, human embryonic kidney; IC50, half maximal inhibitory concentration; ITC, International Transporter Consortium; Ki, inhibitory constant; MATE, multidrug and toxin extrusion protein; MPP+, 1-methyl-4-phenylpyridimium; MRP, multidrug resistance-associated protein; MSD, membrane-spanning domain; MW, molecular weight; NBD, nucleotide-binding domain; NME, new molecular entity; NSAID, non-steroidal anti-inflammatory drugs; Nephrotoxicity; OA, organic anion; OAT or Oat, organic anion transporters; OATP or Oatp, organic anion-transporting peptide; OC, organic cation; OCT or Oct, organic cation transporter; OCTN, Organic zwitterions/cation transporters; Organic anions; Organic cations; P-gp, P-glycoprotein; PAH, p-aminohippurate; Renal drug transporters; SLC, solute carrier; SNP, single-nucleotide polymorphism; TEA, tetraethylammonium; TMD, transmembrane domain; URAT, urate transporter; fe, fraction of the absorbed dose excreted unchanged in urine