title: Relation between lymphocyte to monocyte ratio and short-term mortality in patients with acute pulmonary embolism.
abstract: BACKGROUND
  The relationship between inflammation and mortality after acute pulmonary embolism (APE) has previously been investigated with different variables (platelet/lymphocyte ratio, etc).
  
  
  OBJECTIVE
  We investigated the predictive value of lymphocyte to monocyte ratio (LMR) for mortality in first 30 days after APE.
  
  
  METHODS
  The study population included 264 APE patients of which 230 patients were survivors, 34 patients were non-survivors.
  
  
  RESULTS
  LMR was significantly lower in non-survivors after APE (P < .001). Neutrophil-to-lymphocyte ratio (NLR) was higher in non-survivors after APE (P < .001). Platelet-to-lymphocyte (PLR) had no significance between both groups (P: .241). Simplified pulmonary embolism severity index and LMR were independent predictors of mortality in patients with APE (P: .008 and P: .001, respectively).
  
  
  CONCLUSIONS
  LMR as a novel marker of inflammation seemed to be an independent predictor of short-term mortality in patients with APE.
authors.affiliation: Department of Cardiology, Turkey Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Ahmet Goktug
authors.initials: AG
authors.lastname: Ertem
authors.affiliation: Department of Cardiology, Turkey Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Cagri
authors.initials: C
authors.lastname: Yayla
authors.affiliation: Department of Cardiology, Turkey Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Acar
authors.affiliation: Department of Cardiology, Turkey Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Kirbas
authors.affiliation: Department of Cardiology, Turkey Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Sefa
authors.initials: S
authors.lastname: Unal
authors.affiliation: Department of Chest Diseases, Ataturk Heart Diseases and Thoracic Surgery Training and Research Hospital, Ankara, Turkey.
authors.forename: Melahat
authors.initials: M
authors.lastname: Uzel Sener
authors.affiliation: Department of Cardiology, Turkey Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Mehmet Kadri
authors.initials: MK
authors.lastname: Akboga
authors.affiliation: Department of Cardiology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors.forename: Tolga Han
authors.initials: TH
authors.lastname: Efe
authors.affiliation: Department of Cardiology, Ankara Ataturk Training and Research Hospital, Ankara, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Sivri
authors.affiliation: Department of Cardiology, Turkey Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Sen
authors.affiliation: Department of Cardiology, Turkey Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Gokaslan
authors.affiliation: Department of Cardiology, Turkey Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Topaloglu
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D002423:Cause of Death; D015331:Cohort Studies; D005260:Female; D017052:Hospital Mortality; D006785:Hospitals, University; D006801:Humans; D053208:Kaplan-Meier Estimate; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000166:cytology*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000166:cytology*; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D011655:Pulmonary Embolism / Q000097:blood* / Q000401:mortality* / Q000628:therapy; D012372:ROC Curve; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016019:Survival Analysis; D013997:Time Factors
keywords: acute pulmonary embolism; inflammation; lymphocyte to monocyte ratio; mortality