title: Assessment of serum trace elements and electrolytes in children with childhood and atypical autism.
abstract: The existing data demonstrate a significant interrelation between ASD and essential and toxic trace elements status of the organism. However, data on trace element homeostasis in particular ASD forms are insufficient. Therefore, the objective of the present study was to assess the level of trace elements and electrolytes in serum of children with childhood and atypical autism. A total of 48 children with ASD (24 with childhood and 24 with atypical autism) and age- and sex-adjusted controls were examined. Serum trace elements and electrolytes were assessed using inductively-coupled plasma mass spectrometry. The obtained data demonstrate that children with ASD unspecified are characterized by significantly lower Ni, Cr, and Se levels as compared to the age- and sex-matched controls. At the same time, significantly decreased serum Ni and Se concentrations were detected in patients with childhood autism. In turn, children with atypical autism were characterized by more variable serum trace element spectrum. In particular, atypical autism is associated with lower serum Al, As, Ni, Cr, Mn, and Se levels in comparison to the control values. Moreover, Al and Mn concentration in this group was also lower than that in childhood autism patients. Generally, the obtained data demonstrate lower levels of both essential and toxic trace elements in atypical autism group, being indicative of profound alteration of trace elements metabolism. However, further detailed metabolic studies are required to reveal critical differences in metabolic pathways being responsible for difference in trace element status and clinical course of the disease.
authors.affiliation: All-Russian Research Institute of Medicinal and Aromatic Plants, Moscow, Russia; Orenburg State University, Orenburg, Russia; Yaroslavl State University, Yaroslavl, Russia; RUDN University, Moscow, Russia. Electronic address: skalny3@gmail.com.
authors.forename: Anatoly V
authors.initials: AV
authors.lastname: Skalny
authors.affiliation: Scientific Center for Mental Health, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: Natalia V
authors.initials: NV
authors.lastname: Simashkova
authors.affiliation: Scientific Center for Mental Health, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: Tatiana P
authors.initials: TP
authors.lastname: Klyushnik
authors.affiliation: Yaroslavl State University, Yaroslavl, Russia.
authors.forename: Andrei R
authors.initials: AR
authors.lastname: Grabeklis
authors.affiliation: RUDN University, Moscow, Russia.
authors.forename: Ivan V
authors.initials: IV
authors.lastname: Radysh
authors.affiliation: RUDN University, Moscow, Russia.
authors.forename: Margarita G
authors.initials: MG
authors.lastname: Skalnaya
authors.affiliation: Orenburg State University, Orenburg, Russia; Orenburg State Medical University, Orenburg, Russia.
authors.forename: Alexandr A
authors.initials: AA
authors.lastname: Nikonorov
authors.affiliation: Orenburg State University, Orenburg, Russia; Yaroslavl State University, Yaroslavl, Russia; RUDN University, Moscow, Russia; Orenburg State Medical University, Orenburg, Russia.
authors.forename: Alexey A
authors.initials: AA
authors.lastname: Tinkov
mesh_terms: D000067877:Autism Spectrum Disorder / Q000097:blood; D001321:Autistic Disorder / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D004573:Electrolytes / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D012643:Selenium / Q000097:blood; D014131:Trace Elements / Q000097:blood*
chemical_list: D004573:Electrolytes; D014131:Trace Elements; D012643:Selenium
keywords: Autism spectrum disorders; Metals; Pervasive developmental disorder-not otherwise specified; Selenium