title: Umbilical Cord Blood Transplantation-associated Nephrotic Syndrome Successfully Treated by Low-density Lipoprotein Apheresis.
abstract: The development of nephrotic syndrome (NS) after umbilical cord transplantation (UBT) has been reported in only four cases to date. We herein report the case of a 50-year-old woman who developed NS 94 days after UBT. She fell into oliguria and required dialysis. A kidney biopsy revealed focal and segmental glomerulosclerosis. Although glucocorticoid monotherapy did not improve her condition, the addition of low-density lipoprotein (LDL) apheresis resulted in remission of NS, a drastic improvement in her renal function, and withdrawal from dialysis. To the best of our knowledge, this is the first report of UBT-associated NS treated with LDL apheresis.
authors.affiliation: Department of Nephrology and Endocrinology, The University of Tokyo, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Sugawara
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Honda
authors.forename: Daisuke
authors.initials: D
authors.lastname: Katagiri
authors.forename: Motonobu
authors.initials: M
authors.lastname: Nakamura
authors.forename: Takahisa
authors.initials: T
authors.lastname: Kawakami
authors.forename: Ryo
authors.initials: R
authors.lastname: Nasu
authors.forename: Akimasa
authors.initials: A
authors.lastname: Hayashi
authors.forename: Yukako
authors.initials: Y
authors.lastname: Shintani
authors.forename: Akihiro
authors.initials: A
authors.lastname: Tojo
authors.forename: Eisei
authors.initials: E
authors.lastname: Noiri
authors.forename: Mineo
authors.initials: M
authors.lastname: Kurokawa
authors.forename: Masashi
authors.initials: M
authors.lastname: Fukayama
authors.forename: Masaomi
authors.initials: M
authors.lastname: Nangaku
mesh_terms: D001781:Blood Component Removal / Q000379:methods*; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects*; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications / Q000503:physiopathology; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000209:etiology*
chemical_list: D008077:Lipoproteins, LDL