title: Sitting Less and Moving More: Improved Glycaemic Control for Type 2 Diabetes Prevention and Management.
abstract: Epidemiological evidence indicates that excessive time spent in sedentary behaviours (too much sitting) is associated with an increased risk of type 2 diabetes (T2D). Here, we highlight findings of experimental studies corroborating and extending the epidemiological evidence and showing the potential benefits for T2D of reducing and breaking up sitting time across the whole day. We also discuss future research opportunities and consider emerging implications for T2D prevention and management. This new evidence is stimulating an expansion of diabetes-related physical activity guidelines-suggesting that in addition to moderate-vigorous physical activity, reducing and regularly interrupting prolonged sitting time is likely to have important and varied benefits across the spectrum of diabetes risk.
authors.affiliation: Physical Activity, Behavioural Epidemiology, and Metabolic & Vascular Physiology Laboratories, Baker IDI Heart and Diabetes Institute, Level 4, 99 Commercial Rd, Melbourne, VIC 3004, Australia. Paddy.Dempsey@bakeridi.edu.au.|Central Clinical School, Faculty of Medicine, Nursing & Health Sciences, Monash University, Melbourne, Australia. Paddy.Dempsey@bakeridi.edu.au.
authors.forename: Paddy C
authors.initials: PC
authors.lastname: Dempsey
authors.affiliation: Physical Activity, Behavioural Epidemiology, and Metabolic & Vascular Physiology Laboratories, Baker IDI Heart and Diabetes Institute, Level 4, 99 Commercial Rd, Melbourne, VIC 3004, Australia.|Central Clinical School, Faculty of Medicine, Nursing & Health Sciences, Monash University, Melbourne, Australia.|Swinburne University of Technology, Melbourne, Australia.
authors.forename: Neville
authors.initials: N
authors.lastname: Owen
authors.affiliation: Diabetes Research Centre, University of Leicester and NIHR Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, Leicester, UK.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Yates
authors.affiliation: Physical Activity, Behavioural Epidemiology, and Metabolic & Vascular Physiology Laboratories, Baker IDI Heart and Diabetes Institute, Level 4, 99 Commercial Rd, Melbourne, VIC 3004, Australia.|Central Clinical School, Faculty of Medicine, Nursing & Health Sciences, Monash University, Melbourne, Australia.
authors.forename: Bronwyn A
authors.initials: BA
authors.lastname: Kingwell
authors.affiliation: Physical Activity, Behavioural Epidemiology, and Metabolic & Vascular Physiology Laboratories, Baker IDI Heart and Diabetes Institute, Level 4, 99 Commercial Rd, Melbourne, VIC 3004, Australia.|Central Clinical School, Faculty of Medicine, Nursing & Health Sciences, Monash University, Melbourne, Australia.|Mary MacKillop Institute of Health Research, Australian Catholic University, Melbourne, Australia.
authors.forename: David W
authors.initials: DW
authors.lastname: Dunstan
mesh_terms: D001786:Blood Glucose / Q000032:analysis*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000517:prevention & control*; D015444:Exercise; D006801:Humans; D011187:Posture; D057185:Sedentary Behavior
chemical_list: D001786:Blood Glucose
keywords: Breaks in sedentary time; Cardiometabolic risk; Cardiovascular; Diabetes; Exercise; Glycaemic control; Insulin resistance; Metabolic syndrome; Physical activity; Prediabetes; Sedentary behaviour; Sitting