title: Reduced prealbumin is associated with bone mineral density in women with osteoporosis.
abstract: OBJECTIVE
  Poor nutritional status is associated with osteoporosis (OP) in postmenopausal women. Moreover, recent studies documented that prealbumin is the best and most widely used parameter to monitor nutrition intervention and is a sensitive predictor of short-term outcome compared with albumin. Therefore, the aim of this study was to examine the association of prealbumin levels with bone mineral density (BMD) in patients with OP.
  
  
  METHODS
  This cross-sectional study recruited 664 women. Prealbumin levels and BMD at femoral neck and lumbar spine were measured. Multiple linear regression analysis was performed to assess the correlation between prealbumin and BMD.
  
  
  RESULTS
  Results of this study found that prealbumin levels dropped gradually as BMD decreased. Furthermore, partial correlation analysis revealed that prealbumin was correlated with BMD after adjusting for confounders. Multiple linear regression analysis showed that prealbumin is a significant factor for reduced BMD in women (for BMD at spine L2-4, β = 0.186, P < 0.001; for BMD at femoral neck, β = 0.180, P < 0.001).
  
  
  CONCLUSIONS
  Prealbumin was significantly correlated with BMD after adjusting for traditional cardiovascular risk factors. Further prospective research is warranted to further enhance our understanding of the important role of prealbumin in OP.
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.
authors.forename: Xue-Song
authors.initials: XS
authors.lastname: Li
authors.affiliation: International Physical Examination and Healthy Center, The Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.
authors.forename: Ji-Rong
authors.initials: JR
authors.lastname: Zhang
authors.affiliation: Harbin Medical University (Da Qing), Harbin, Heilongjiang, China.
authors.forename: Yi-Lin
authors.initials: YL
authors.lastname: Zhao
authors.affiliation: International Physical Examination and Healthy Center, The Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: Children's Nutrition Research Center, Huffington Center on Aging, Departments of Pediatrics & Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.
authors.forename: Yuxiang
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Division of Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas.
authors.forename: Tiemin
authors.initials: T
authors.lastname: Liu
authors.affiliation: Department of Internal Medicine, The Third Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China. Electronic address: Ruitaowang@126.com.
authors.forename: Rui-Tao
authors.initials: RT
authors.lastname: Wang
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000453:epidemiology; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D015986:Confounding Factors, Epidemiologic; D003430:Cross-Sectional Studies; D015536:Down-Regulation; D005260:Female; D006801:Humans; D016014:Linear Models; D008875:Middle Aged; D009752:Nutritional Status; D015663:Osteoporosis, Postmenopausal / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology*; D011228:Prealbumin / Q000032:analysis*; D015203:Reproducibility of Results; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D011228:Prealbumin
keywords: Bone mineral density; Nutrition; Osteoporosis; Prealbumin