title: Ventral striatum dysfunction in children and adolescents with reactive attachment disorder: functional MRI study.
abstract: BACKGROUND
  Child maltreatment is a major risk factor for psychopathology, including reactive attachment disorder (RAD).
  
  
  OBJECTIVE
  To examine whether neural activity during reward processing was altered in children and adolescents with RAD.
  
  
  METHODS
  Sixteen children and adolescents with RAD and 20 typically developing (TD) individuals performed tasks with high and low monetary rewards while undergoing functional magnetic resonance imaging.
  
  
  RESULTS
  Significantly reduced activity in the caudate and nucleus accumbens was observed during the high monetary reward condition in the RAD group compared with the TD group (P=0.015, family-wise error-corrected cluster level). Significant negative correlations between bilateral striatal activity and avoidant attachment were observed in the RAD and TD groups.
  
  
  CONCLUSIONS
  Striatal neural reward activity in the RAD group was markedly decreased. The present results suggest that dopaminergic dysfunction occurs in the striatum of children and adolescents with RAD, leading towards potential future risks for psychopathology.
  
  
  BACKGROUND
  None.
  © The Royal College of Psychiatrists 2015. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence.
authors.affiliation: , MD, Advanced Biomedical Sciences Course, Graduate School of Medical Sciences, and Research Center for Child Mental Development, University of Fukui, Fukui, Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Takiguchi
authors.affiliation: , PhD, Division of Developmental Higher Brain Functions, United Graduate School of Child Development, and Research Center for Child Mental Development, University of Fukui, Fukui, Japan.
authors.forename: Takashi X
authors.initials: TX
authors.lastname: Fujisawa
authors.affiliation: , MA, Division of Developmental Higher Brain Functions, United Graduate School of Child Development, and Research Center for Child Mental Development, University of Fukui, Fukui, Japan.
authors.forename: Sakae
authors.initials: S
authors.lastname: Mizushima
authors.affiliation: , PhD, Division of Developmental Higher Brain Functions, United Graduate School of Child Development, University of Fukui, Research Center for Child Mental Development, University of Fukui, and Biomedical Imaging Research Center, University of Fukui, Fukui, Japan.
authors.forename: Daisuke N
authors.initials: DN
authors.lastname: Saito
authors.affiliation: , PhD, Division of Developmental Higher Brain Functions, United Graduate School of Child Development, University of Fukui, Fukui, Research Center for Child Mental Development, University of Fukui, Fukui.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Okamoto
authors.affiliation: , PhD, Division of Developmental Higher Brain Functions, United Graduate School of Child Development, University of Fukui, Research Center for Child Mental Development, University of Fukui, and Biomedical Imaging Research Center, University of Fukui, Fukui, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Shimada
authors.affiliation: , PhD, Research Center for Child Mental Development, University of Fukui, Fukui, Japan.
authors.forename: Michiko
authors.initials: M
authors.lastname: Koizumi
authors.affiliation: , MD, Division of Developmental Higher Brain Functions, United Graduate School of Child Development, and Research Center for Child Mental Development, University of Fukui, Fukui, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kumazaki
authors.affiliation: , PhD, Division of Developmental Higher Brain Functions, United Graduate School of Child Development, and Research Center for Child Mental Development, University of Fukui, Fukui, Japan.
authors.forename: Minyoung
authors.initials: M
authors.lastname: Jung
authors.affiliation: , MD, PhD, Division of Developmental Higher Brain Functions, United Graduate School of Child Development, University of Fukui, Research Center for Child Mental Development, University of Fukui, and Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Kosaka
authors.affiliation: , MD, PhD, Research Center for Child Mental Development, University of Fukui, Hiratani Clinic for Developmental Disorders of Children, Fukui, Japan.
authors.forename: Michio
authors.initials: M
authors.lastname: Hiratani
authors.affiliation: , MD, PhD, Research Center for Child Mental Development, and Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
authors.forename: Yusei
authors.initials: Y
authors.lastname: Ohshima
authors.affiliation: , MD, PhD, Developmental Biopsychiatry Research Program, McLean Hospital, Belmont, Massachusetts, Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Martin H
authors.initials: MH
authors.lastname: Teicher
authors.affiliation: , MD, PhD, Division of Developmental Higher Brain Functions, United Graduate School of Child Development, and Research Center for Child Mental Development, University of Fukui, Fukui.
authors.forename: Akemi
authors.initials: A
authors.lastname: Tomoda