title: An Overview of Nonsteroidal Antiinflammatory Drug Reactions.
abstract: Nonsteroidal antiinflammatory drugs (NSAIDs), including aspirin, are among the most commonly used drugs worldwide. They account for a large number of adverse drug reactions (ADRs). The prevalence of NSAID-induced reactions is increasing. Distinguishing between a predicted side effect of a drug and a potentially life-threatening hypersensitivity reaction is essential to manage the affected patient. However, most clinicians find it difficult to diagnose these types of reactions despite published classification schemes. In this overview, we provide an in-depth review of NSAID classification, types of NSAID reactions, diagnostic tactics, and management strategies to provide the reader with a greater understanding of NSAID-induced reactions.
authors.affiliation: Department of Allergy, Asthma & Immunology, Scripps Clinic, 3811 Valley Centre Drive, San Diego, CA 92130, USA.
authors.forename: Kristen M
authors.initials: KM
authors.lastname: Walters
authors.affiliation: Department of Allergy, Asthma & Immunology, Scripps Clinic, 3811 Valley Centre Drive, San Diego, CA 92130, USA. Electronic address: Woessner.katharine@scrippshealth.org.
authors.forename: Katharine M
authors.initials: KM
authors.lastname: Woessner
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000145:classification; D019468:Disease Management; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy*; D006801:Humans
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal
keywords: Aspirin intolerance; Drug allergy; NSAID hypersensitivity; NSAID reactions; NSAID-induced asthma; NSAID-induced urticaria; Nonsteroidal antiinflammatory drugs (NSAIDs)