title: Novel Structural Hybrids on the Base of Benzofuroxans and Furoxans. Mini-Review.
abstract: Hybrid drug strategy is based on the combination of two or more pharmacophores into a new chemical entity to improve the properties of the original compounds or to obtain double action of resulting molecule. Hybrid molecules, comprised of some pharmacophore and nitric oxide (NO) donor moiety, constitute one of the more promising approaches for the design of drugs. Furoxans and benzofuroxans are considered NO releasing prodrugs and are of great interest for researchers. In this review we will focus on furoxan and benzofuroxan hybrids described in literature during the last years (from 2005 to 2016).
authors.affiliation: A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, Kazan, Tatarstan,. Russian Federation.
authors.forename: Elena A
authors.initials: EA
authors.lastname: Chugunova
authors.affiliation: A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, Kazan, Tatarstan,. Russian Federation.
authors.forename: Alexander R
authors.initials: AR
authors.lastname: Burilov
mesh_terms: D000818:Animals; D001583:Benzoxazoles / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D009569:Nitric Oxide / Q000737:chemistry / Q000378:metabolism*; D020030:Nitric Oxide Donors / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D010069:Oxadiazoles / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D011355:Prodrugs / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D001583:Benzoxazoles; D020030:Nitric Oxide Donors; D010069:Oxadiazoles; D011355:Prodrugs; C010166:furoxans; D009569:Nitric Oxide; C014354:benzofuroxan
keywords: Benzofuroxan; Furoxan; Hybrid; NO-donor; Pharmacophore.