title: Rab-mediated vesicle trafficking in cancer.
abstract: A large group of small Rab GTPases which mediate secretory and endosomal membrane transport, as well as autophagosome biogenesis, are essential components of vesicle trafficking machinery. Specific Rab protein together with the cognate effectors coordinates the dynamics of trafficking pathway and determines the cargo proteins destination. Functional impairments of Rab proteins by mutations or post-translational modifications disrupting the regulatory network of vesicle trafficking have been implicated in tumorigenesis. Therefore, the vesicle transport regulators play essential roles in the mediation of cancer cell biology, including uncontrolled cell growth, invasion and metastasis. The context-dependent role of the same Rab to act as either an oncoprotein or tumor suppressor in different cancers is found. Such discrepancies may be due in part to the interaction of specific Rab protein with different effectors or cargos in various tumors. Here, we review recent advances in the roles of Rab GTPases in communicating with other effectors in tumor progression. In this review, we also emphasize dysregulation of Rab-mediated membrane delivery shifting normal cell behaviors toward malignancy. Thus, recovery of the dysregulated vesicle trafficking systems in cancer cells may provide future directions for potential strategy to restrain tumor progression.
authors.affiliation: Department of Pharmacology, National Cheng Kung University, College of Medicine, No.1, University Road, Tainan, 70101, Taiwan, People's Republic of China.
authors.forename: Hong-Tai
authors.initials: HT
authors.lastname: Tzeng
authors.affiliation: Department of Pharmacology, National Cheng Kung University, College of Medicine, No.1, University Road, Tainan, 70101, Taiwan, People's Republic of China. ycw5798@mail.ncku.edu.tw.|Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, No.1, University Road, Tainan, 70101, Taiwan, People's Republic of China. ycw5798@mail.ncku.edu.tw.
authors.forename: Yi-Ching
authors.initials: YC
authors.lastname: Wang
mesh_terms: D001692:Biological Transport; D063646:Carcinogenesis / Q000235:genetics* / Q000378:metabolism; D011992:Endosomes / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D021381:Protein Transport; D020691:rab GTP-Binding Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D020691:rab GTP-Binding Proteins
keywords: Cancer; Effector; Rab protein; Vesicle trafficking