title: DNA damage-induced inflammation and nuclear architecture.
abstract: Nuclear architecture and the chromatin state affect most-if not all- DNA-dependent transactions, including the ability of cells to sense DNA lesions and restore damaged DNA back to its native form. Recent evidence points to functional links between DNA damage sensors, DNA repair mechanisms and the innate immune responses. The latter raises the question of how such seemingly disparate processes operate within the intrinsically complex nuclear landscape and the chromatin environment. Here, we discuss how DNA damage-induced immune responses operate within chromatin and the distinct sub-nuclear compartments highlighting their relevance to chronic inflammation.
authors.affiliation: Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Nikolaou Plastira 100, 70013, Heraklion, Crete, Greece.
authors.forename: Kalliopi
authors.initials: K
authors.lastname: Stratigi
authors.affiliation: Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Nikolaou Plastira 100, 70013, Heraklion, Crete, Greece.
authors.forename: Ourania
authors.initials: O
authors.lastname: Chatzidoukaki
authors.affiliation: Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Nikolaou Plastira 100, 70013, Heraklion, Crete, Greece; Department of Biology, University of Crete, Vassilika Vouton, GR71409, Heraklion, Crete, Greece. Electronic address: garinis@imbb.forth.gr.
authors.forename: George A
authors.initials: GA
authors.lastname: Garinis
mesh_terms: D000818:Animals; D002843:Chromatin / Q000235:genetics / Q000276:immunology*; D004249:DNA Damage / Q000276:immunology*; D004260:DNA Repair / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000235:genetics / Q000276:immunology / Q000473:pathology
chemical_list: D002843:Chromatin
keywords: DNA damage; Inflammation; Innate immunity; Nuclear architecture