title: Outer Retinal and Choroidal Evaluation in Multiple Evanescent White Dot Syndrome (MEWDS): An Enhanced Depth Imaging Optical Coherence Tomography Study.
abstract: OBJECTIVE
  To perform an analysis of optical coherence tomography (OCT) abnormalities in patients with MEWDS, during the acute and recovery stages, using enhanced depth imaging-OCT (EDI-OCT).
  
  
  METHODS
  A retrospective case series of five patients with MEWDS was included. EDI-OCT imaging was evaluated to detect retinal and choroidal features.
  
  
  RESULTS
  In the acute phase, focal impairment of the ellipsoid zone and external limiting membrane, hyperreflective dots in the inner choroid, and full-thickness increase of the choroidal profile were observed in the affected eye; disappearance of these findings and restoration of the choroidal thickness (p = 0.046) was appreciated in the recovery phase. No OCT abnormalities were assessed in the unaffected eye.
  
  
  CONCLUSIONS
  EDI-OCT revealed transient outer retinal layer changes and inner choroidal hyperreflective dots. A transient increased thickness of the whole choroid was also identified. This might confirm a short-lasting inflammatory involvement of the whole choroidal tissue in the active phase of MEWDS.
authors.affiliation: a Department of Biomedical and Surgical Sciences, Section of Ophthalmology , University of Perugia, S. Maria della Misericordia Hospital , Perugia , Italy.
authors.forename: Tito
authors.initials: T
authors.lastname: Fiore
authors.affiliation: a Department of Biomedical and Surgical Sciences, Section of Ophthalmology , University of Perugia, S. Maria della Misericordia Hospital , Perugia , Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Iaccheri
authors.affiliation: a Department of Biomedical and Surgical Sciences, Section of Ophthalmology , University of Perugia, S. Maria della Misericordia Hospital , Perugia , Italy.
authors.forename: Alessio
authors.identifier: http://orcid.org/0000-0003-2765-0639
authors.initials: A
authors.lastname: Cerquaglia
authors.affiliation: a Department of Biomedical and Surgical Sciences, Section of Ophthalmology , University of Perugia, S. Maria della Misericordia Hospital , Perugia , Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Lupidi
authors.affiliation: a Department of Biomedical and Surgical Sciences, Section of Ophthalmology , University of Perugia, S. Maria della Misericordia Hospital , Perugia , Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Torroni
authors.affiliation: b Department of Internal Medicine , University of Perugia, S. Maria della Misericordia Hospital , Perugia , Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Fruttini
authors.affiliation: a Department of Biomedical and Surgical Sciences, Section of Ophthalmology , University of Perugia, S. Maria della Misericordia Hospital , Perugia , Italy.
authors.forename: Carlo
authors.identifier: http://orcid.org/0000-0002-3812-9219
authors.initials: C
authors.lastname: Cagini
mesh_terms: D000208:Acute Disease; D000328:Adult; D015862:Choroid Diseases / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012164:Retinal Diseases / Q000000981:diagnostic imaging*; D055213:Retinal Pigment Epithelium / Q000000981:diagnostic imaging; D012189:Retrospective Studies; D013577:Syndrome; D041623:Tomography, Optical Coherence / Q000379:methods*; D055815:Young Adult
keywords: Choroidal hyperreflective dots; choroidal thickness; ellipsoid zone; enhanced depth imaging; external limiting membrane; multiple evanescent white dot syndrome; optical coherence tomography