title: Radical trideuteromethylation with deuterated dimethyl sulfoxide in the synthesis of heterocycles and labelled building blocks.
abstract: The potential of deuterated pharmaceuticals is being widely demonstrated. Here we describe the first trideuteromethylation under radical reaction conditions using deuterated dimethyl sulfoxide as a reagent for the synthesis of labelled heterocycles and trideuteromethylated compounds. A broad scope of the developed method for the synthesis of various scaffolds was demonstrated.
authors.affiliation: Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straβe 11, 44227 Dortmund, Germany. andrey.antonchick@mpi-dortmund.mpg.de and Chemical Biology, Department of Chemistry and Chemical Biology, Technical University Dortmund, Otto-Hahn-Straβe 4a, 44227 Dortmund, Germany and Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Caporaso
authors.affiliation: Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straβe 11, 44227 Dortmund, Germany. andrey.antonchick@mpi-dortmund.mpg.de and Chemical Biology, Department of Chemistry and Chemical Biology, Technical University Dortmund, Otto-Hahn-Straβe 4a, 44227 Dortmund, Germany.
authors.forename: Srimanta
authors.initials: S
authors.lastname: Manna
authors.affiliation: Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straβe 11, 44227 Dortmund, Germany. andrey.antonchick@mpi-dortmund.mpg.de and Chemical Biology, Department of Chemistry and Chemical Biology, Technical University Dortmund, Otto-Hahn-Straβe 4a, 44227 Dortmund, Germany.
authors.forename: Sarah
authors.initials: S
authors.lastname: Zinken
authors.affiliation: Department of Chemistry, Lomonosov Moscow State University, 1/3 Leninskie Gory, 119991 Moscow, Russia.
authors.forename: Alexander R
authors.initials: AR
authors.lastname: Kochnev
authors.affiliation: Department of Chemistry, Lomonosov Moscow State University, 1/3 Leninskie Gory, 119991 Moscow, Russia.
authors.forename: Evgeny R
authors.initials: ER
authors.lastname: Lukyanenko
authors.affiliation: Department of Chemistry, Lomonosov Moscow State University, 1/3 Leninskie Gory, 119991 Moscow, Russia.
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Kurkin
authors.affiliation: Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straβe 11, 44227 Dortmund, Germany. andrey.antonchick@mpi-dortmund.mpg.de and Chemical Biology, Department of Chemistry and Chemical Biology, Technical University Dortmund, Otto-Hahn-Straβe 4a, 44227 Dortmund, Germany.
authors.forename: Andrey P
authors.initials: AP
authors.lastname: Antonchick