title: Characterization of human pineal gland proteome.
abstract: The pineal gland is a neuroendocrine gland located at the center of the brain. It is known to regulate various physiological functions in the body through secretion of the neurohormone melatonin. Comprehensive characterization of the human pineal gland proteome has not been undertaken to date. We employed a high-resolution mass spectrometry-based approach to characterize the proteome of the human pineal gland. A total of 5874 proteins were identified from the human pineal gland in this study. Of these, 5820 proteins were identified from the human pineal gland for the first time. Interestingly, 1136 proteins from the human pineal gland were found to contain a signal peptide domain, which indicates the secretory nature of these proteins. An unbiased global proteomic profile of this biomedically important organ should benefit molecular research to unravel the role of the pineal gland in neuropsychiatric and neurodegenerative diseases.
authors.affiliation: Institute of Bioinformatics, International Technology Park, Bangalore 560 066, India. keshav@ibioinformatics.org soujanya@ibioinformatics.org manish@ibioinformatics.org anil@ibioinformatics.org lathika@ibioinformatics.org gourav@ibioinformatics.org sandip@ibioinformatics.org gajanan@ibioinformatics.org harsha@ibioinformatics.org and School of Biotechnology, KIIT University, Bhubaneswar 751 024, India. ppmathur@yahoo.com.
authors.forename: Soujanya D
authors.initials: SD
authors.lastname: Yelamanchi
authors.affiliation: Institute of Bioinformatics, International Technology Park, Bangalore 560 066, India. keshav@ibioinformatics.org soujanya@ibioinformatics.org manish@ibioinformatics.org anil@ibioinformatics.org lathika@ibioinformatics.org gourav@ibioinformatics.org sandip@ibioinformatics.org gajanan@ibioinformatics.org harsha@ibioinformatics.org and Manipal University, Madhav Nagar, Manipal 576 104, India.
authors.forename: Manish
authors.initials: M
authors.lastname: Kumar
authors.affiliation: Institute of Bioinformatics, International Technology Park, Bangalore 560 066, India. keshav@ibioinformatics.org soujanya@ibioinformatics.org manish@ibioinformatics.org anil@ibioinformatics.org lathika@ibioinformatics.org gourav@ibioinformatics.org sandip@ibioinformatics.org gajanan@ibioinformatics.org harsha@ibioinformatics.org and Centre for Bioinformatics, Pondicherry University, Puducherry 605 014, India.
authors.forename: Anil K
authors.initials: AK
authors.lastname: Madugundu
authors.affiliation: Institute of Bioinformatics, International Technology Park, Bangalore 560 066, India. keshav@ibioinformatics.org soujanya@ibioinformatics.org manish@ibioinformatics.org anil@ibioinformatics.org lathika@ibioinformatics.org gourav@ibioinformatics.org sandip@ibioinformatics.org gajanan@ibioinformatics.org harsha@ibioinformatics.org.
authors.forename: Lathika
authors.initials: L
authors.lastname: Gopalakrishnan
authors.affiliation: Institute of Bioinformatics, International Technology Park, Bangalore 560 066, India. keshav@ibioinformatics.org soujanya@ibioinformatics.org manish@ibioinformatics.org anil@ibioinformatics.org lathika@ibioinformatics.org gourav@ibioinformatics.org sandip@ibioinformatics.org gajanan@ibioinformatics.org harsha@ibioinformatics.org and Manipal University, Madhav Nagar, Manipal 576 104, India.
authors.forename: Gourav
authors.initials: G
authors.lastname: Dey
authors.affiliation: Institute of Bioinformatics, International Technology Park, Bangalore 560 066, India. keshav@ibioinformatics.org soujanya@ibioinformatics.org manish@ibioinformatics.org anil@ibioinformatics.org lathika@ibioinformatics.org gourav@ibioinformatics.org sandip@ibioinformatics.org gajanan@ibioinformatics.org harsha@ibioinformatics.org and Manipal University, Madhav Nagar, Manipal 576 104, India.
authors.forename: Sandip
authors.initials: S
authors.lastname: Chavan
authors.affiliation: Institute of Bioinformatics, International Technology Park, Bangalore 560 066, India. keshav@ibioinformatics.org soujanya@ibioinformatics.org manish@ibioinformatics.org anil@ibioinformatics.org lathika@ibioinformatics.org gourav@ibioinformatics.org sandip@ibioinformatics.org gajanan@ibioinformatics.org harsha@ibioinformatics.org and Manipal University, Madhav Nagar, Manipal 576 104, India.
authors.forename: Gajanan
authors.initials: G
authors.lastname: Sathe
authors.affiliation: School of Biotechnology, KIIT University, Bhubaneswar 751 024, India. ppmathur@yahoo.com and Centre for Bioinformatics, Pondicherry University, Puducherry 605 014, India.
authors.forename: Premendu P
authors.initials: PP
authors.lastname: Mathur
authors.affiliation: Institute of Bioinformatics, International Technology Park, Bangalore 560 066, India. keshav@ibioinformatics.org soujanya@ibioinformatics.org manish@ibioinformatics.org anil@ibioinformatics.org lathika@ibioinformatics.org gourav@ibioinformatics.org sandip@ibioinformatics.org gajanan@ibioinformatics.org harsha@ibioinformatics.org and School of Biotechnology, KIIT University, Bhubaneswar 751 024, India. ppmathur@yahoo.com and YU-IOB Center for Systems Biology and Molecular Medicine, Yenepoya University, Mangalore 575 018, India.
authors.forename: Harsha
authors.initials: H
authors.lastname: Gowda
authors.affiliation: Department of Neuropathology, National Institute of Mental Health and Neuro Sciences, Bangalore 560 029, India. shankarsk2004@gmail.com anita_mahadevan@yahoo.com and Human Brain Tissue Repository, Neurobiology Research Centre, National Institute of Mental Health and Neuro Sciences, Bangalore 560 029, India.
authors.forename: Anita
authors.initials: A
authors.lastname: Mahadevan
authors.affiliation: Department of Neuropathology, National Institute of Mental Health and Neuro Sciences, Bangalore 560 029, India. shankarsk2004@gmail.com anita_mahadevan@yahoo.com and Human Brain Tissue Repository, Neurobiology Research Centre, National Institute of Mental Health and Neuro Sciences, Bangalore 560 029, India and Proteomics and Bioinformatics Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neuro Sciences, Bangalore 560 029, India.
authors.forename: Susarla K
authors.initials: SK
authors.lastname: Shankar
authors.affiliation: Institute of Bioinformatics, International Technology Park, Bangalore 560 066, India. keshav@ibioinformatics.org soujanya@ibioinformatics.org manish@ibioinformatics.org anil@ibioinformatics.org lathika@ibioinformatics.org gourav@ibioinformatics.org sandip@ibioinformatics.org gajanan@ibioinformatics.org harsha@ibioinformatics.org and YU-IOB Center for Systems Biology and Molecular Medicine, Yenepoya University, Mangalore 575 018, India and Proteomics and Bioinformatics Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neuro Sciences, Bangalore 560 029, India.
authors.forename: T S Keshava
authors.initials: TS
authors.lastname: Prasad
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D008297:Male; D008550:Melatonin / Q000378:metabolism; D053858:Metabolic Networks and Pathways; D008875:Middle Aged; D056950:Period Circadian Proteins / Q000378:metabolism; D010870:Pineal Gland / Q000378:metabolism*; D020543:Proteome; D040901:Proteomics / Q000379:methods; D053719:Tandem Mass Spectrometry; D055815:Young Adult
chemical_list: D056950:Period Circadian Proteins; D020543:Proteome; D018698:Glutamic Acid; D008550:Melatonin