title: Organ Chips: Quality Assurance Systems in Regenerative Medicine.
abstract: A class of novel therapies leverages regenerative cell types in disease microenvironments. This complex interplay challenges established good manufacturing practices, as standards and analytical tools to measure regenerative potency are missing. That is, we can build the product right, but we do not know if we are building the right product. Here, we suggest that organ-chips, biomimetic in vitro phenotyping platforms, can serve as key quality assurance systems in regenerative medicine.
authors.affiliation: Institute for Regenerative Medicine (IREM), University of Zurich, Wyss Translational Center, University and ETH Zurich, Zurich, Switzerland.|Wyss Institute for Biologically Inspired Engineering and School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.
authors.forename: F S
authors.initials: FS
authors.lastname: Pasqualini
authors.affiliation: Institute for Regenerative Medicine (IREM), University of Zurich, Wyss Translational Center, University and ETH Zurich, Zurich, Switzerland.|Wyss Institute for Biologically Inspired Engineering and School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.|Division of Surgical Research and Clinic for Cardiovascular Research, University Hospital of Zurich, Zurich, Switzerland.
authors.forename: M Y
authors.initials: MY
authors.lastname: Emmert
authors.affiliation: Institute for Regenerative Medicine (IREM), University of Zurich, Wyss Translational Center, University and ETH Zurich, Zurich, Switzerland.|Wyss Institute for Biologically Inspired Engineering and School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.
authors.forename: K K
authors.initials: KK
authors.lastname: Parker
authors.affiliation: Institute for Regenerative Medicine (IREM), University of Zurich, Wyss Translational Center, University and ETH Zurich, Zurich, Switzerland.|Wyss Institute for Biologically Inspired Engineering and School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.|Division of Surgical Research and Clinic for Cardiovascular Research, University Hospital of Zurich, Zurich, Switzerland.
authors.forename: S P
authors.initials: SP
authors.lastname: Hoerstrup
mesh_terms: D040761:Biomimetic Materials; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D060833:Cellular Microenvironment; D006801:Humans; D010641:Phenotype; D011785:Quality Assurance, Health Care; D044968:Regenerative Medicine / Q000379:methods* / Q000592:standards