title: Optic disc tilt direction affects regional visual field progression rates in myopic eyes with open-angle glaucoma.
abstract: OBJECTIVE
  To compare global and regional visual field (VF) progression rates and determine clinical factors associated with rapid VF progression in myopic patients with open-angle glaucoma (OAG) with different disc tilt directions.
  
  
  METHODS
  The medical records of 182 eyes from 182 myopic OAG patients with progressive VF deterioration during follow-up were analyzed. The rates of change in the mean thresholds of the global and regional VF areas of the horizontal and vertical disc tilt (HDT and VDT) groups were compared using a linear mixed model after controlling for confounding covariates. Clinical factors associated with rapid VF progression in global and regional VF areas were investigated.
  
  
  RESULTS
  The VDT group showed significantly faster VF progression at inferior regional zones than the HDT group (P < 0.05). Based on a multivariate linear mixed model, VDT was associated with faster bi-hemifield VF progression in the GHT map, whereas HDT was associated with faster single-hemifield VF progression.
  
  
  CONCLUSIONS
  Myopic OAG eyes show significantly different regional VF progression rates according to disc tilt direction. VDT is an independent predictor of a rapid rate of regional VF progression in both hemifields, whereas HDT predicts rapid regional VF progression in a single hemifield.
authors.affiliation: Yonsei Plus Eye Hospital, Bundang, Gyunggido, South Korea.
authors.forename: Jong Rak
authors.initials: JR
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.
authors.forename: Jiyun
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.
authors.forename: Jong-Eun
authors.initials: JE
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.
authors.forename: Jin Young
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea. mskook@amc.seoul.kr.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Kook
mesh_terms: D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D009412:Nerve Fibers / Q000473:pathology; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D011379:Prognosis; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012189:Retrospective Studies; D013997:Time Factors; D041623:Tomography, Optical Coherence; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology*
keywords: Bi-hemifield; Horizontal disc tilt; Optic disc tilt; Single hemifield; Vertical disc tilt; Visual field progression rate