title: Preliminary Evaluation of a Sitafloxacin-Containing Regimen for Relapsed or Refractory PulmonaryMycobacterium aviumComplex Disease.
abstract: Although sitafloxacin (STFX) is known to have a favorable minimum inhibitory concentration forMycobacterium avium, few studies have evaluated the clinical efficacy of an STFX-containing regimen for pulmonaryM aviumcomplex (MAC) disease. To evaluate the clinical efficacy of STFX-containing regimens for relapsed or refractory pulmonary MAC disease, we retrospectively reviewed 18 patients with pulmonary MAC disease who received STFX for at least 4 weeks for pulmonary MAC disease between January 2008 and February 2016. Of 18 patients, 10 (55.6%) showed improved radiological characteristics and 8 (44.4%) showed negative sputum cultures at 6 months. Regarding the clinical symptoms, improvements were observed in decreasing order in sputum production (77.8%), cough (72.2%), and malaise (55.6%). Common adverse events included nausea or vomiting (38.9%), followed by loose stool or diarrhea (27.8%) and sleepiness (11.1%). Although this study contained a small number of subjects, we describe a STFX-containing regimen that was effective in achieving sputum culture negative conversions and had an acceptable adverse events profile.
authors.affiliation: Division of Respiratory Medicine , National Hospital Organization Kyoto Medical Center.
authors.forename: Kohei
authors.initials: K
authors.lastname: Fujita
authors.affiliation: Department of Respiratory Medicine, Faculty of Medicine , Fukuoka University.
authors.forename: Masaki
authors.initials: M
authors.lastname: Fujita
authors.affiliation: Department of Respiratory Medicine, Allergy and Clinical Immunology, School of Medical Sciences , Nagoya City University.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Ito
authors.affiliation: Department of Respiratory Medicine , Graduate School of Medicine , Kyoto University , Japan.
authors.forename: Toyohiro
authors.initials: T
authors.lastname: Hirai
authors.affiliation: Division of Respiratory Medicine , National Hospital Organization Kyoto Medical Center.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Mio
authors.affiliation: Department of Respiratory Medicine, Faculty of Medicine , Fukuoka University.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: Department of Respiratory Medicine , Graduate School of Medicine , Kyoto University , Japan.
authors.forename: Michiaki
authors.initials: M
authors.lastname: Mishima
keywords: Mycobacterium avium complex; fluoroquinolone; nontuberculous mycobacteria; salvage therapy; sitafloxacin