title: Angiotensin-I Converting Enzyme (ACE) Inhibitory and Anti-Hypertensive Effect of Protein Hydrolysate from Actinopyga lecanora (Sea Cucumber) in Rats.
abstract: Food protein hydrolysates are known to exhibit angiotensin converting enzyme (ACE) inhibitory properties and can be used as a novel functional food for prevention of hypertension. This study evaluated the ACE inhibitory potentials ofActinopyga lecanoraproteolysate (ALP) in vivo. The pre-fed rats with ALP at various doses (200, 400, 800 mg/kg body weight) exhibited a significant (p≤ 0.05) suppression effect after inducing hypertension. To determine the optimum effective dose that will produce maximal reduction in blood pressure, ALP at three doses was fed to the rats after inducing hypertension. The results showed that the 800 mg/kg body weight dose significantly reduced blood pressure without noticeable negative physiological effect. In addition, there were no observable changes in the rats' heart rate after oral administration of the ALP. It was concluded thatActinopyga lecanoraproteolysate could potentially be used for the development of functional foods and nutraceuticals for prevention and treatment of hypertension.
authors.affiliation: Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia. mahdokht_vishkaiee@yahoo.com.
authors.forename: Mahdokht
authors.initials: M
authors.lastname: Sadegh Vishkaei
authors.affiliation: Department of Chemistry, Sam Houston State University, Huntsville, TX 77340, USA. afshin.ebrahimpour@gmail.com.
authors.forename: Afshin
authors.initials: A
authors.lastname: Ebrahimpour
authors.affiliation: Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia. azizahah@upm.edu.my.
authors.forename: Azizah
authors.initials: A
authors.lastname: Abdul-Hamid
authors.affiliation: Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia. amin@medic.upm.edu.my.
authors.forename: Amin
authors.initials: A
authors.lastname: Ismail
authors.affiliation: Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia. nazamid@upm.edu.my.
authors.forename: Nazamid
authors.initials: N
authors.lastname: Saari
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000737:chemistry / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D011492:Protein Hydrolysates / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D017207:Rats, Sprague-Dawley; D012616:Sea Cucumbers / Q000737:chemistry*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D011492:Protein Hydrolysates
keywords: ACE inhibition; hypertension; normotensive rats; sea cucumber