title: Multivalent effect of glycopolypeptide based nanoparticles for galectin binding.
abstract: Synthetic glycopolypeptides are versatile glycopolymers used to conceive bioinspired nanoassemblies. In this work, novel amphiphilic glycopolypeptides were designed to incorporate lactose or galactan in order to prepare polymeric nanoassemblies with sizes below 50 nm. The bioactivity of the two different outer surface sugar units was evaluated by defining glycan relative binding affinities to human galectins 1 and 3. A specific multivalent effect was found only for polymeric nanoparticles displaying galactan with a significant increase of the binding activity as compared to free glycan in solution. Such synthetic designs present great potential as therapeutic tools to address galectin related pathologies.
authors.affiliation: Université de Bordeaux, LCPO, CNRS, UMR 5629, F-33600, Pessac, France. lecommandoux@enscbp.fr and CNRS, LCC (Laboratoire de Chimie de Coordination (UPR8241)), 205 route de Narbonne, F-31077 Toulouse, France. colin.bonduelle@lcc-toulouse.fr.
authors.forename: Colin
authors.initials: C
authors.lastname: Bonduelle
authors.affiliation: Université de Bordeaux, LCPO, CNRS, UMR 5629, F-33600, Pessac, France. lecommandoux@enscbp.fr and Inserm, U1026, Tissue Bioengineering, University of Bordeaux, Bordeaux Cedex, 33076, France.
authors.forename: Hugo
authors.initials: H
authors.lastname: Oliveira
authors.affiliation: Université de Bordeaux, LCPO, CNRS, UMR 5629, F-33600, Pessac, France. lecommandoux@enscbp.fr.
authors.forename: Cony
authors.initials: C
authors.lastname: Gauche
authors.affiliation: School of Chemical Sciences, Dublin City University, Dublin 9, Ireland.
authors.forename: Jin
authors.initials: J
authors.lastname: Huang
authors.affiliation: School of Chemical Sciences, Dublin City University, Dublin 9, Ireland and Polymer Chemistry and Biomaterials Laboratory, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
authors.forename: Andreas
authors.initials: A
authors.lastname: Heise
authors.affiliation: Université de Bordeaux, LCPO, CNRS, UMR 5629, F-33600, Pessac, France. lecommandoux@enscbp.fr.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Lecommandoux
mesh_terms: D037161:Galectins / Q000737:chemistry / Q000378:metabolism*; D006020:Glycopeptides / Q000737:chemistry / Q000378:metabolism*; D007785:Lactose / Q000737:chemistry / Q000378:metabolism; D018625:Microscopy, Atomic Force; D053758:Nanoparticles / Q000737:chemistry / Q000378:metabolism*; D010316:Particle Size; D011108:Polymers / Q000737:chemistry / Q000378:metabolism; D011134:Polysaccharides / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding; D013499:Surface Properties
chemical_list: D037161:Galectins; D006020:Glycopeptides; D011108:Polymers; D011134:Polysaccharides; D007785:Lactose