title: An Autopsy Case of Lepidic Pulmonary Metastasis from Cholangiocarcinoma.
abstract: We herein report the first case of pulmonary metastasis with lepidic growth that originated from cholangiocarcinoma. A 77-year-old man was admitted to our hospital due to exertional dyspnea and liver dysfunction. Computed tomography showed widespread infiltration and a ground-glass opacity in the lung and dilation of the intrahepatic bile duct. The pulmonary lesion progressed rapidly, and the patient died of respiratory failure. Cholangiocarcinoma and lepidic pulmonary metastasis were pathologically diagnosed by an autopsy. Lepidic pulmonary growth is an atypical pattern of metastasis, and immunopathological staining is useful to distinguish pulmonary metastasis from extrapulmonary cancer and primary pulmonary adenocarcinoma.
authors.affiliation: Department of Respiratory Medicine, National Hospital Organization Nagasaki Medical Center, Japan.
authors.forename: Yohsuke
authors.initials: Y
authors.lastname: Nagayoshi
authors.forename: Kazuko
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Satoru
authors.initials: S
authors.lastname: Hashimoto
authors.forename: Keiko
authors.initials: K
authors.lastname: Hisatomi
authors.forename: Seiji
authors.initials: S
authors.lastname: Doi
authors.forename: Seiji
authors.initials: S
authors.lastname: Nagashima
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kurohama
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ito
authors.forename: Takahiro
authors.initials: T
authors.lastname: Takazono
authors.forename: Shigeki
authors.initials: S
authors.lastname: Nakamura
authors.forename: Taiga
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary*; D000077192:Adenocarcinoma of Lung; D000368:Aged; D001344:Autopsy; D001650:Bile Duct Neoplasms / Q000175:diagnosis / Q000473:pathology*; D001653:Bile Ducts, Intrahepatic / Q000473:pathology; D018281:Cholangiocarcinoma / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary*; D008297:Male; D014057:Tomography, X-Ray Computed