title: Recent Tissue Engineering Advances for the Treatment of Temporomandibular Joint Disorders.
abstract: Temporomandibular disorders (TMDs) are among the most common maxillofacial complaints and a major cause of orofacial pain. Although current treatments provide short- and long-term relief, alternative tissue engineering solutions are in great demand. Particularly, the development of strategies, providing long-term resolution of TMD to help patients regain normal function, is a high priority. An absolute prerequisite of tissue engineering is to understand normal structure and function. The current knowledge of anatomical, mechanical, and biochemical characteristics of the temporomandibular joint (TMJ) and associated tissues will be discussed, followed by a brief description of current TMD treatments. The main focus is on recent tissue engineering developments for regenerating TMJ tissue components, with or without a scaffold. The expectation for effectively managing TMD is that tissue engineering will produce biomimetic TMJ tissues that recapitulate the normal structure and function of the TMJ.
authors.affiliation: Department of Biomedical Engineering, University of California, Davis, One Shields Avenue, Davis, CA, 95616, USA.
authors.forename: Ashkan
authors.initials: A
authors.lastname: Aryaei
authors.affiliation: Department of Biomedical Engineering, University of California, Davis, One Shields Avenue, Davis, CA, 95616, USA.
authors.forename: Natalia
authors.initials: N
authors.lastname: Vapniarsky
authors.affiliation: Department of Biomedical Engineering, University of California, Davis, One Shields Avenue, Davis, CA, 95616, USA.
authors.forename: Jerry C
authors.initials: JC
authors.lastname: Hu
authors.affiliation: Department of Biomedical Engineering, University of California, Davis, One Shields Avenue, Davis, CA, 95616, USA. athanasiou@ucdavis.edu.|Department of Orthopedic Surgery, School of Medicine, University of California, Davis, Sacramento, CA, 95817, USA. athanasiou@ucdavis.edu.
authors.forename: Kyriacos A
authors.initials: KA
authors.lastname: Athanasiou
mesh_terms: D051445:Fibrocartilage; D006801:Humans; D013704:Temporomandibular Joint; D019224:Temporomandibular Joint Disc; D013705:Temporomandibular Joint Disorders / Q000628:therapy*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
keywords: Condylar fibrocartilage; Scaffold-based tissue engineering; Scaffold-free tissue engineering; TMD treatment methods; Temporomandibular joint disc; Temporomandibular joint disorder