title: Role of Endogenous Sulfur Dioxide in Regulating Vascular Structural Remodeling in Hypertension.
abstract: Sulfur dioxide (SO2), an emerging gasotransmitter, was discovered to be endogenously generated in the cardiovascular system. Recently, the physiological effects of endogenous SO2were confirmed. Vascular structural remodeling (VSR), an important pathological change in many cardiovascular diseases, plays a crucial role in the pathogenesis of the diseases. Here, the authors reviewed the research progress of endogenous SO2in regulating VSR by searching the relevant data from PubMed and Medline. In spontaneously hypertensive rats (SHRs) and pulmonary hypertensive rats, SO2/aspartate aminotransferase (AAT) pathway was significantly altered. SO2inhibited vascular smooth muscle cell (VSMC) proliferation, promoted apoptosis, inhibited the synthesis of extracellular collagen but promoted its degradation, and enhanced antioxidative capacity, thereby playing a significant role in attenuating VSR. However, the detailed mechanisms needed to be further explored. Further studies in this field would be important for the better understanding of the pathogenesis of systemic hypertension and pulmonary hypertension. Also, clinical trials are needed to demonstrate if SO2would be a potential therapeutic target in cardiovascular diseases.
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
authors.forename: Jia
authors.identifier: 0000-0002-6927-1971
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
authors.forename: Yaqian
authors.identifier: 0000-0001-8346-3809
authors.initials: Y
authors.lastname: Huang
authors.affiliation: University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Selena
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China; Key Lab of Molecular Cardiovascular Science of Ministry of Education, Beijing 100191, China.
authors.forename: Chaoshu
authors.initials: C
authors.lastname: Tang
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
authors.forename: Hongfang
authors.identifier: 0000-0002-1606-8988
authors.initials: H
authors.lastname: Jin
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
authors.forename: Junbao
authors.identifier: 0000-0001-9036-4980
authors.initials: J
authors.lastname: Du
mesh_terms: D000818:Animals; D006801:Humans; D006973:Hypertension / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D008954:Models, Biological; D013458:Sulfur Dioxide / Q000378:metabolism*; D066253:Vascular Remodeling
chemical_list: D013458:Sulfur Dioxide