title: Nuclear envelope rupture: Actin fibers are putting the squeeze on the nucleus.
abstract: Cells exhibit transient nuclear envelope ruptures during interphase, but the responsible biophysical processes remain unclear. In this issue, Hatch and Hetzer (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603053) show that actin fibers constrict the nucleus, causing chromatin protrusions and nuclear membrane ruptures at sites with nuclear lamina defects.
authors.affiliation: Nancy E. and Peter C. Meinig School of Biomedical Engineering, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853 jan.lammerding@cornell.edu.
authors.forename: Jan
authors.initials: J
authors.lastname: Lammerding
authors.affiliation: Department of Cell Biology, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
authors.forename: Katarina
authors.initials: K
authors.lastname: Wolf
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism; D000199:Actins / Q000378:metabolism*; D000205:Actomyosin / Q000378:metabolism; D000818:Animals; D002460:Cell Line; D006801:Humans; D034921:Lamin Type B / Q000378:metabolism; D008954:Models, Biological; D009685:Nuclear Envelope / Q000378:metabolism*
chemical_list: D000199:Actins; D034921:Lamin Type B; D000205:Actomyosin