title: Unilateral gonadoblastoma with dysgerminoma in normal fertile woman having a child: Extremely rare occurrence with characteristic immunohistomorphology.
abstract: Gonadoblastomas (GBYs) are rare gonadal tumors almost always arising from a dysgenetic gonad with a Y chromosome. Very rarely, GBYs appear in otherwise normal women with a history of pregnancy. The typical histological appearance of GBY can be altered by extensive deposition of basement membrane material, calcification, or overgrowth by a malignant tumor. Less than 10 cases have been reported with normal 46XX karyotype. Only six cases of GBY have been described in pregnant women. We present a unique case of GBY with dysgerminoma in a genotypically and phenotypically normal woman with a history of normal pregnancy, absence of virilization, and characteristic immunohistomorphological features.
authors.affiliation: Department of Pathology, Shrimati Kashibai Navale Medical College and General Hospital, Pune, Maharashtra, India.
authors.forename: Maithili Mandar
authors.initials: MM
authors.lastname: Kulkarni
authors.affiliation: Department of Pathology, Shrimati Kashibai Navale Medical College and General Hospital, Pune, Maharashtra, India.
authors.forename: Siddhi Gaurish
authors.initials: SG
authors.lastname: Sinai Khandeparkar
authors.affiliation: Department of Pathology, Shrimati Kashibai Navale Medical College and General Hospital, Pune, Maharashtra, India.
authors.forename: Avinash R
authors.initials: AR
authors.lastname: Joshi
authors.affiliation: Department of Pathology, Shrimati Kashibai Navale Medical College and General Hospital, Pune, Maharashtra, India.
authors.forename: Pallavi V
authors.initials: PV
authors.lastname: Bhayekar
mesh_terms: D000469:Alkaline Phosphatase / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D004407:Dysgerminoma / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology; D005260:Female; D058851:GPI-Linked Proteins / Q000032:analysis; D018238:Gonadoblastoma / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D007265:Inhibins / Q000032:analysis; D007527:Isoenzymes / Q000032:analysis; D008853:Microscopy; D011247:Pregnancy; D014746:Vimentin / Q000032:analysis; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D058851:GPI-Linked Proteins; D007527:Isoenzymes; D014746:Vimentin; D007265:Inhibins; D000469:Alkaline Phosphatase; C019839:alkaline phosphatase, placental