title: Role of the Cytoskeleton in Myeloid Cell Function.
abstract: During an innate immune response, myeloid cells undergo complex morphological adaptations in response to inflammatory cues, which allow them to exit the vasculature, enter the tissues, and destroy invading pathogens. The actin and microtubule cytoskeletons are central to many of the most essential cellular functions including cell division, cell morphology, migration, intracellular trafficking, and signaling. Cytoskeletal structure and regulation are crucial for many myeloid cell functions, which require rapid and dynamic responses to extracellular signals. In this chapter, we review the roles of the actin and microtubule cytoskeletons in myeloid cells, focusing primarily on their roles in chemotaxis and phagocytosis. The role of myeloid cell cytoskeletal defects in hematological disorders is highlighted throughout.
authors.affiliation: Department of Dentistry, Matrix Dynamics Group, University of Toronto, Toronto, ON M5S 3E2, Canada.
authors.forename: Noah
authors.initials: N
authors.lastname: Fine
authors.affiliation: Department of Dentistry, Matrix Dynamics Group, University of Toronto, Toronto, ON M5S 3E2, Canada.
authors.forename: Samira
authors.initials: S
authors.lastname: Khaliq
authors.affiliation: Department of Dentistry, Matrix Dynamics Group, University of Toronto, Toronto, ON M5S 3E2, Canada.
authors.forename: Siavash
authors.initials: S
authors.lastname: Hassanpour
authors.affiliation: Department of Dentistry, Matrix Dynamics Group, University of Toronto, Toronto, ON M5S 3E2, Canada.
authors.forename: Michael
authors.initials: M
authors.lastname: Glogauer
mesh_terms: D000818:Animals; D002633:Chemotaxis; D003599:Cytoskeleton / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate; D022423:Myeloid Cells / Q000502:physiology*; D010587:Phagocytosis