title: The IgH 3' regulatory region and c-myc-induced B-cell lymphomagenesis.
abstract: Deregulation and mutations of c-myc have been reported in multiple mature B-cell malignancies such as Burkitt lymphoma, myeloma and plasma cell lymphoma. After translocation into the immunoglobulin heavy chain (IgH) locus, c-myc is constitutively expressed under the control of active IgH cis-regulatory enhancers. Those located in the IgH 3' regulatory region (3'RR) are master control elements of transcription. Over the past decade numerous convincing demonstrations of 3'RR's contribution to mature c-myc-induced lymphomagenesis have been made using transgenic models with various types of IgH-c-myc translocations and transgenes. This review highlights how IgH 3'RR physiological functions play a critical role in c-myc deregulation during lymphomagenesis.
authors.affiliation: Université de Limoges, Centre National de la Recherche Scientifique, CNRS UMR, France.
authors.forename: Nour
authors.initials: N
authors.lastname: Ghazzaui
authors.affiliation: Université de Limoges, Centre National de la Recherche Scientifique, CNRS UMR, France.
authors.forename: Alexis
authors.initials: A
authors.lastname: Saintamand
authors.affiliation: Université de Limoges, Centre National de la Recherche Scientifique, CNRS UMR, France.
authors.forename: Hussein
authors.initials: H
authors.lastname: Issaoui
authors.affiliation: Université de Limoges, Centre National de la Recherche Scientifique, CNRS UMR, France.
authors.forename: Christelle
authors.initials: C
authors.lastname: Vincent-Fabert
authors.affiliation: Université de Limoges, Centre National de la Recherche Scientifique, CNRS UMR, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Denizot
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D016393:Lymphoma, B-Cell / Q000235:genetics*; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*; D012045:Regulatory Sequences, Nucleic Acid; D014158:Transcription, Genetic; D014178:Translocation, Genetic
chemical_list: D007143:Immunoglobulin Heavy Chains; C489427:MYC protein, human; D016271:Proto-Oncogene Proteins c-myc
keywords: 3’ regulatory region; HDAC; c-myc; lymphomagenesis; transgenic mice