title: Combinations of drugs in the Treatment of Obesity.
abstract: Obesity is a chronic disease associated with excess morbidity and mortality. Clinical treatment, however, currently offers disappointing results, with very high rates of weight loss failure or weight regain cycles, and only two drugs (orlistat and sibutramine) approved for long-term use. Drugs combinations can be an option for its treatment but, although widely used in clinical practice, very few data are available in literature for its validation. Our review focuses on the rationale for their use, with advantages and disadvantages; on combinations often used, with or without studies; and on new perspectives of combinations being studied mainly by the pharmaceutical industry.
authors.affiliation: Obesity & Metabolic Syndrome Group, Discipline of Endocrinology & Metabolism, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 255, 7º andar, sala 7037, 05403-000 - São Paulo, SP, Brazil. brunohalpern@hotmail.com.
authors.forename: Bruno
authors.initials: B
authors.lastname: Halpern
authors.affiliation: Obesity & Metabolic Syndrome Group, Discipline of Endocrinology & Metabolism, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 255, 7º andar, sala 7037, 05403-000 - São Paulo, SP, Brazil. eduardolorena@uol.com.br.
authors.forename: Eduardo S L
authors.initials: ES
authors.lastname: Oliveira
authors.affiliation: Obesity & Metabolic Syndrome Group, Discipline of Endocrinology & Metabolism, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 255, 7º andar, sala 7037, 05403-000 - São Paulo, SP, Brazil. andremfaria@hotmail.com.
authors.forename: André M
authors.initials: AM
authors.lastname: Faria
authors.affiliation: Obesity & Metabolic Syndrome Group, Discipline of Endocrinology & Metabolism, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 255, 7º andar, sala 7037, 05403-000 - São Paulo, SP, Brazil. alfredo.halpern@netpoint.com.br.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Halpern
authors.affiliation: Laboratory of Carbohydrates and Radioimuneassay/LIM-18, Faculty of Medicine, University of São Paulo, Av. Dr Arnaldo, 455 01246-903 - São Paulo, SP, Brazil. medna@usp.br.
authors.forename: Maria Edna de
authors.initials: ME
authors.lastname: Melo
authors.affiliation: Obesity & Metabolic Syndrome Group, Discipline of Endocrinology & Metabolism, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 255, 7º andar, sala 7037, 05403-000 - São Paulo, SP, Brazil. ccercato@netpoint.com.br.
authors.forename: Cintia
authors.initials: C
authors.lastname: Cercato
authors.affiliation: Laboratory of Carbohydrates and Radioimuneassay/LIM-18, Faculty of Medicine, University of São Paulo, Av. Dr Arnaldo, 455 01246-903 - São Paulo, SP, Brazil. mmancini@usp.br.
authors.forename: Marcio C
authors.initials: MC
authors.lastname: Mancini
keywords: 5-hydroxytryptophan; antidepressants; bupropion; caffeine; carbidopa; drug combination; ephedrine; fenfluramine; glucagon-like peptide-1; leptin; metformin; metreleptin; naltrexone; noradrenergic drugs; orlistat; peptide YY; phentermine; pramlintide; sibutramine; topiramate; zonisamide