title: Organofluorine Isoselenocyanate Analogues of Sulforaphane: Synthesis and Anticancer Activity.
abstract: A series of previously unknown sulforaphane analogues with organofluorine substituents bonded to the sulfinyl sulfur atom, an isoselenocyanate moiety in place of the isothiocyanate group, the central sulfur atom in various oxidation states, and different numbers of methylene groups in the central alkyl chain were synthesized and fully characterized. All new compounds were tested for their biological properties in vitro and demonstrated much higher anticancer activity against two breast cancer cell lines than that shown by native sulforaphane; at the same time, the compounds were less toxic for normal cells. The influence of the particular structural changes in the molecules on the cytotoxicity is discussed.
authors.affiliation: Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Department of Heteroorganic Chemistry, Sienkiewicza 112, 90363, Łódź, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Cierpiał
authors.affiliation: Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Department of Heteroorganic Chemistry, Sienkiewicza 112, 90363, Łódź, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Łuczak
authors.affiliation: Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Department of Heteroorganic Chemistry, Sienkiewicza 112, 90363, Łódź, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Kwiatkowska
authors.affiliation: Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Department of Heteroorganic Chemistry, Sienkiewicza 112, 90363, Łódź, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Kiełbasiński
authors.affiliation: National Medicines Institute, Department of Cell Biology, Chełmska 30/34, 00725, Warszawa, Poland.|Warsaw University of Medicine, Faculty of Pharmaceutics and the Department of Laboratory Medicine, Banacha 1, 02097, Warszawa, Poland.
authors.forename: Lidia
authors.initials: L
authors.lastname: Mielczarek
authors.affiliation: National Medicines Institute, Department of Cell Biology, Chełmska 30/34, 00725, Warszawa, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Wiktorska
authors.affiliation: National Medicines Institute, Department of Cell Biology, Chełmska 30/34, 00725, Warszawa, Poland.
authors.forename: Zdzisław
authors.initials: Z
authors.lastname: Chilmonczyk
authors.affiliation: National Medicines Institute, Department of Cell Biology, Chełmska 30/34, 00725, Warszawa, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Milczarek
authors.affiliation: Warsaw University of Medicine, Faculty of Pharmaceutics and the Department of Laboratory Medicine, Banacha 1, 02097, Warszawa, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Karwowska
keywords: antitumor agents; fluorine; isoselenocyanates; sulforaphane; sulfur