title: Quercetin suppresses lung cancer growth by targeting Aurora B kinase.
abstract: aurora B kinase is highly expressed in several cancer cells and promotes tumorigenesis and progression, and therefore, it is an important target for drug to treat tumors. Quercetin was identified to be an antitumor agent. Herein, we report for the first time that quercetin inhibited aurora B activities by directly binding with aurora B in vitro and in vivo. Ex vivo studies showed that quercetin inhibited aurora B activities in JB6 Cl41 cells and A549 lung cancer cells. Moreover, knockdown of aurora B in A549 cells decreased their sensitivities to quercetin. In vivo study demonstrated that injection of quercetin in A549 tumor-bearing mice effectively suppressed cancer growth. The phosphorylation of histone 3 in tumor tissues was also decreased after quercetin treatment. In short, quercetin can suppress growth of lung cancer cells as an aurora B inhibitor both in vitro and in vivo.
authors.affiliation: Department of Respiratory, The Second Affiliated Hospital to Shanxi College of Traditional Chinese Medicine, Xianyang, 712000, China.
authors.forename: Zhu
authors.initials: Z
authors.lastname: Xingyu
authors.affiliation: Department of Pharmacy, Baoji Central Hospital, Baoji, 721008, China.
authors.forename: Ma
authors.initials: M
authors.lastname: Peijie
authors.affiliation: Department of Pulmonary Medicine, Affiliated Hospital of Yan'an University, Yan'an, 716000, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Dan
authors.affiliation: Department of Chest Surgery, Ankang Central Hospital of Shanxi Province, Ankang, Shanxi, 725000, China.
authors.forename: Wang
authors.initials: W
authors.lastname: Youg
authors.affiliation: Department of Chest Surgery, Ankang Central Hospital of Shanxi Province, Ankang, Shanxi, 725000, China.
authors.forename: Wang
authors.initials: W
authors.lastname: Daojun
authors.affiliation: Department of Nephrological, Baoji city chinese medicine hospital, Baoji, 721001, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Xinzheng
authors.affiliation: Department of Thoracic Surgery, Chang 'an Hospital in Xi'an, Xi'an Shaanxi, 710016, China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Xijun
authors.affiliation: Department of Chest Surgery, Tumor Hospital of Shannxi Province, Xi'an, Shannxi, 710061, China.
authors.forename: Song
authors.initials: S
authors.lastname: Yangrong
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis; D064107:Aurora Kinase B / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D004195:Disease Models, Animal; D019008:Drug Resistance, Neoplasm; D055785:Gene Knockdown Techniques; D006801:Humans; D008175:Lung Neoplasms; D008546:Melanoma, Experimental; D051379:Mice; D011485:Protein Binding; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D011794:Quercetin / Q000494:pharmacology*; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D011794:Quercetin; D064107:Aurora Kinase B
keywords: aurora B; inhibitor; lung cancer cells; quercetin