title: Nrf2-a Promising Therapeutic Target for Defensing Against Oxidative Stress in Stroke.
abstract: Stroke is one of the leading causes of death and disability in the world. Oxidative stress, which refers to an excessive generation of reactive oxygen species (ROS), plays a key role in the pathological process of stroke. Excessive ROS production contributes to brain ischemia/reperfusion injury through many mechanisms including BBB disruption, inflammation, apoptosis, and cellular necrosis. Nuclear factor-E2-related factor 2 (Nrf2) is one of the critical regulators of endogenous antioxidant defense, which promote the transcription of a wide variety of antioxidant genes. Emerging evidence has demonstrated that activation of Nrf2 and its target genes may protect the brain against ischemia/reperfusion injury, and therapies aimed at increasing Nrf2 activity appear to be beneficial to alleviate brain injury in stroke through the suppression of oxidative stress. The main purpose of this review is to discuss the current evidence for the role of Nrf2 in stroke and the potential interventions to enhance Nrf2 activation to attenuate stroke-induced injury.
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
authors.forename: Rongrong
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Neurology, The Ninth People's Hospital of Chongqing, Chongqing, 400070, China.
authors.forename: Mengxue
authors.initials: M
authors.lastname: Xu
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Xie
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. qinxinyuecqchina@hotmail.com.
authors.forename: Xinyue
authors.initials: X
authors.lastname: Qin
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D051267:NF-E2-Related Factor 2 / Q000235:genetics / Q000378:metabolism*; D018384:Oxidative Stress / Q000235:genetics*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D020521:Stroke / Q000235:genetics / Q000378:metabolism* / Q000473:pathology
chemical_list: D051267:NF-E2-Related Factor 2; D017382:Reactive Oxygen Species
keywords: Antioxidants; Nrf2; Reactive oxygen species; Stroke