title: Efficacy and safety of oxaliplatin, bevacizumab and oral S-1 for advanced recurrent colorectal cancer.
abstract: The aim of this study was to evaluate the efficacy and safety of co-administration of oral S-1 and oxaliplatin (SOX) in combination with bevacizumab (bev) in patients with advanced recurrent colorectal cancer. A retrospective study of 36 patients with advanced recurrent colorectal cancer was performed, of whom 27 received first-line and 9 received second-line SOX+bev chemotherapy between 2010 and 2013 at the Hachioji Digestive Disease Hospital (Hachioji, Japan). The SOX+bev regimen consisted of administration of intravenous oxaliplatin (85 mg/m2) on days 1 and 14, bevacizumab (5 mg/kg) on day 1, and co-administration of oral S-1 twice daily on days 1-14. The drug regimen was repeated every 4 weeks. SOX+bev treatment was associated with a response rate of 45.2%, a disease control rate of 71%, and a median progression-free survival (PFS) and overall survival (OS) of 9.9 and 21.9 months, respectively. Patients who received first-line chemotherapy benefited from treatment in terms of prolonged PFS (13.8 months) and OS (28.2 months). Grade 3/4 adverse events were infrequent and included anaemia, thrombocytopenia, anorexia, diarrhea, sensory neuropathy, increased aspartate aminotransferase level and skin rash. In conclusion, SOX+bev therapy was found to be feasible and safe for patients with advanced and recurrent colorectal cancer.
authors.affiliation: Department of Gastroenterological Surgery, Ibaraki Medical Center, Tokyo Medical University, Amimachi, Ibaraki 300-0395, Japan.
authors.forename: Shuji
authors.initials: S
authors.lastname: Suzuki
authors.affiliation: Department of Gastroenterological Surgery, Ibaraki Medical Center, Tokyo Medical University, Amimachi, Ibaraki 300-0395, Japan.
authors.forename: Jiro
authors.initials: J
authors.lastname: Shimazaki
authors.affiliation: Department of Surgery, Hachioji Digestive Disease Hospital, Hachioji, Tokyo 192-0903, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Morishita
authors.affiliation: Department of Surgery, Hachioji Digestive Disease Hospital, Hachioji, Tokyo 192-0903, Japan.
authors.forename: Nobusada
authors.initials: N
authors.lastname: Koike
authors.affiliation: Department of Surgery, Hachioji Digestive Disease Hospital, Hachioji, Tokyo 192-0903, Japan.
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Harada
authors.affiliation: Department of Surgery, Hachioji Digestive Disease Hospital, Hachioji, Tokyo 192-0903, Japan.
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Hayashi
authors.affiliation: Department of Surgery, Hachioji Digestive Disease Hospital, Hachioji, Tokyo 192-0903, Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Suzuki
keywords: S-1; SOX+bev; bevacizumab; colorectal cancer; oxaliplatin