title: Synthesis of Psoralidin derivatives and their anticancer activity: First synthesis of Lespeflorin I1.
abstract: Synthetic scheme for the preparation of a number of different derivatives of anticancer natural product Psoralidin is described. A convergent synthetic approach is followed using simple starting materials like substituted phenyl acetic esters and benzoic acids. The developed synthetic route leads us to complete the first synthesis of an analogous natural product Lespeflorin I1, a mild melanin synthesis inhibitor. Preliminary bioactivity studies of the synthesized compounds are carried out against two commonly used prostate cancer cell lines. Results show that the bioactivity of the compounds can be manipulated by the simple modification of the functional groups.
authors.affiliation: Chemical Science and Technology Division, CSIR - North East Institute of Science & Technology, Jorhat-785006, Assam, India; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S. Limestone St., Lexington, Kentucky-40536, United States.
authors.forename: Pallab
authors.initials: P
authors.lastname: Pahari
authors.affiliation: Chemical Science and Technology Division, CSIR - North East Institute of Science & Technology, Jorhat-785006, Assam, India.
authors.forename: Ujwal Pratim
authors.initials: UP
authors.lastname: Saikia
authors.affiliation: Department of Urology, University of Louisville, Louisville, KY 40292, United States.
authors.forename: Trinath Prasad
authors.initials: TP
authors.lastname: Das
authors.affiliation: Department of Urology, University of Louisville, Louisville, KY 40292, United States.
authors.forename: Chendil
authors.initials: C
authors.lastname: Damodaran
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S. Limestone St., Lexington, Kentucky-40536, United States.
authors.forename: Jurgen
authors.initials: J
authors.lastname: Rohr