title: Role of Yes-associated protein in cancer: An update.
abstract: Yes-associated protein (YAP) is an oncoprotein located in the cytoplasm in an inactive form, and when activated, it translocates to the nucleus and activates the transcription of genes responsible for cell division and apoptosis. YAP is one of the downstream regulatory proteins in the Hippo signaling pathway, which is important in cell proliferation and regeneration. Due to its great importance, YAP is regulated very strictly by different regulatory systems. The present review will focus on the canonical pathways of YAP, and will provide details on the most recent findings regarding its regulation and role in tumorigenesis, specifically in prostate tumor progression.
authors.affiliation: Department of Biology, Nazarbayev University School of Science and Technology, Astana 010000, Republic of Kazakhstan.
authors.forename: Ramazan
authors.initials: R
authors.lastname: Abylkassov
authors.affiliation: Department of Biology, Nazarbayev University School of Science and Technology, Astana 010000, Republic of Kazakhstan.
authors.forename: Yingqiu
authors.initials: Y
authors.lastname: Xie
keywords: YAP; cancer; prostate cancer