title: Cytotoxic melodinus-type alkaloids from the ethanol extract of Melodinus fusiformis.
abstract: A chemical investigation of the ethanol extract of the aerial parts of Melodinus fusiformis led to the isolation of six new melodinus-type alkaloids, melofusines A-E (1-6), along with one known compound, melodinine B. Structural elucidation of all the compounds was performed by spectral methods such as 1D and 2D NMR, IR, UV and HRESIMS. The isolated compounds were tested in vitro for cytotoxic potential against six tumor cell lines (Hep-2, SCL-1, CAL-27, UMSCC-1, Detroit-562 and TCA-83). As a result, compound 1 exhibited significant cytotoxic activities against all tested tumor cell lines with IC50values <5μM.
authors.affiliation: School of Nursing, Xuzhou Medical University, Xuzhou 221004, PR China; School of Nursing, Second Military Medical University, Shanghai 200433, PR China.
authors.forename: Xian-Ping
authors.initials: XP
authors.lastname: Tang
authors.affiliation: Department of Joint Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, PR China.
authors.forename: Shi-Qi
authors.initials: SQ
authors.lastname: Cao
authors.affiliation: Department of Pharmacy, 455 Hospital of People's Liberation Army, West Huaihai Road 338, Shanghai 200052, PR China. Electronic address: songyan455@gmail.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Song
authors.affiliation: School of Nursing, Second Military Medical University, Shanghai 200433, PR China. Electronic address: zhoulanshu@hotmail.com.
authors.forename: Lan-Shu
authors.initials: LS
authors.lastname: Zhou
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D029062:Apocynaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts
keywords: Apocynaceae; Cytotoxicity; Indole alkaloids; Melodinus fusiformis