title: Nanoscale patterning of biopolymers for functional biosurfaces and controlled drug release.
abstract: We compare the rates of drug release from nanopatterned and flat biodegradable polymer surfaces, and observe significantly lower release rates from the nanopatterned surfaces. Specifically, we nanopattern poly(l-lactic acid) (PLLA), a biodegradable polymer frequently used for fabricating drug-eluting coronary stents, through microtransfer molding and solvent casting and investigate the nanopattern's impact on the release of sirolimus, an immunosuppressant agent, coated on the PLLA surface using high performance liquid chromatography/mass spectrometry. We find that PLLA surfaces nanopatterned with 750 nm-pitch nanocup or nanocone arrays exhibit drug release rates significantly lower (25-30%) than that of the flat surface, which is counter-intuitive given the nanopattern-induced increase in their surface areas. Based on diffusion and meniscus curvature minimization analyses, we attribute the decreased drug release rate to the incomplete wetting of the nanopatterned surface. These results provide new insights on how the surface nanopatterning of biomaterials can functionalize the surface and tailor the release kinetics of therapeutic agents coated on it for controlled drug elution.
authors.affiliation: Microelectronics Research Center, Iowa State University, Ames, IA, 50011 USA and Department of Electrical and Computer Engineering, Iowa State University, Ames, IA, 50011 USA. biswasr@iastate.edu plasmon@iastate.edu and Ames Laboratory, Ames, IA, 50011 USA.
authors.forename: Akshit
authors.identifier: http://orcid.org/0000-0001-7336-2529
authors.initials: A
authors.lastname: Peer
authors.affiliation: Department of Electrical and Computer Engineering, Iowa State University, Ames, IA, 50011 USA. biswasr@iastate.edu plasmon@iastate.edu.
authors.forename: Rabin
authors.initials: R
authors.lastname: Dhakal
authors.affiliation: Microelectronics Research Center, Iowa State University, Ames, IA, 50011 USA and Department of Electrical and Computer Engineering, Iowa State University, Ames, IA, 50011 USA. biswasr@iastate.edu plasmon@iastate.edu and Ames Laboratory, Ames, IA, 50011 USA and Department of Physics and Astronomy, Iowa State University, Ames, IA, 50011 USA.
authors.forename: Rana
authors.initials: R
authors.lastname: Biswas
authors.affiliation: Microelectronics Research Center, Iowa State University, Ames, IA, 50011 USA and Department of Electrical and Computer Engineering, Iowa State University, Ames, IA, 50011 USA. biswasr@iastate.edu plasmon@iastate.edu.
authors.forename: Jaeyoun
authors.initials: J
authors.lastname: Kim
mesh_terms: D001704:Biopolymers / Q000737:chemistry*; D065546:Drug Liberation; D054855:Drug-Eluting Stents; D036103:Nanotechnology; D011091:Polyesters / Q000737:chemistry*; D020123:Sirolimus / Q000008:administration & dosage*
chemical_list: D001704:Biopolymers; D011091:Polyesters; C033616:poly(lactide); D020123:Sirolimus