title: Stanniocalcin 1 Enhances Carbon Flux from Glucose to Lipids in White Retroperitoneal Adipose Tissue in the Fed Rat.
abstract: The present work assesses in vitro the role of human Stanniocalcin 1 (hSTC-1) in glucose metabolism in white retroperitoneal adipose tissue (WRAT) from fed rat. In the fed state, hSTC1 increases the incorporation of14C from glucose into lipids in the rat WRAT. The increase in lipogenesis capacity supports the hypothesis that the activity of the glycerol-3-phosphate-generating pathway (glycolysis) from glucose is regulated by hSTC-1. The effect of hSTC-1 on de novo fatty acid synthesis and on glucose oxidation in WRAT is supported by an 85 % increase in14CO2production from14C-glucose. The incubation of WRAT in the presence of hSTC-1 maintained the ADP/ATP ratio close to the control group. The presence of hSTC-1 in the incubation medium did not inhibit the lipolytic effect of epinephrine. In conclusion, hSTC-1 is one of the hormonal factors that control glucose metabolism in WRAT in the fed state.
authors.affiliation: Department of Physiology, Institute of Health Sciences, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, 90050-170, Porto Alegre, RS, Brazil. alinecozer15@gmail.com.
authors.forename: Aline G
authors.initials: AG
authors.lastname: Cozer
authors.affiliation: Department of Physiology, Institute of Health Sciences, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, 90050-170, Porto Alegre, RS, Brazil.
authors.forename: Márcia
authors.initials: M
authors.lastname: Trapp
authors.affiliation: Department of Physiology, Institute of Health Sciences, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, 90050-170, Porto Alegre, RS, Brazil.
authors.forename: Claudia
authors.initials: C
authors.lastname: Vieira Marques
authors.affiliation: Department of Physiology, Institute of Health Sciences, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, 90050-170, Porto Alegre, RS, Brazil.
authors.forename: Tiago L
authors.initials: TL
authors.lastname: Martins
authors.affiliation: Department of Physiology, Institute of Health Sciences, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, 90050-170, Porto Alegre, RS, Brazil.
authors.forename: Jorge Felipe A
authors.initials: JF
authors.lastname: Model
authors.affiliation: Department of Physiology, Institute of Health Sciences, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, 90050-170, Porto Alegre, RS, Brazil.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Schein
authors.affiliation: Department of Physiology, Institute of Health Sciences, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, 90050-170, Porto Alegre, RS, Brazil.
authors.forename: Luiz Carlos
authors.initials: LC
authors.lastname: Kucharski
authors.affiliation: Department of Physiology, Institute of Health Sciences, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, 90050-170, Porto Alegre, RS, Brazil.
authors.forename: Roselis S M
authors.initials: RS
authors.lastname: Da Silva
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D052436:Adipose Tissue, White / Q000378:metabolism*; D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism; D050155:Lipogenesis; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005227:Fatty Acids; D006023:Glycoproteins; D002245:Carbon Dioxide; C051795:teleocalcin; D000255:Adenosine Triphosphate; D005947:Glucose
keywords: Endocrinology; Lipid metabolism