title: Collective migration under hydrodynamic interactions: a computational approach.
abstract: We consider a generic model for cell motility. Even if a comprehensive understanding of cell motility remains elusive, progress has been achieved in its modelling using a whole-cell physical model. The model takes into account the main mechanisms of cell motility, actin polymerization, actin-myosin dynamics and substrate mediated adhesion (if applicable), and combines them with steric cell-cell and hydrodynamic interactions. The model predicts the onset of collective cell migration, which emerges spontaneously as a result of inelastic collisions of neighbouring cells. Each cell here modelled as an active polar gel is accomplished with two vortices if it moves. Upon collision of two cells, the two vortices which come close to each other annihilate. This leads to a rotation of the cells and together with the deformation and the reorientation of the actin filaments in each cell induces alignment of these cells and leads to persistent translational collective migration. The effect for low Reynolds numbers is as strong as in the non-hydrodynamic model, but it decreases with increasing Reynolds number.
authors.affiliation: Institut für Wissenschaftliches Rechnen , TU Dresden , 01062 Dresden , Germany.
authors.forename: W
authors.initials: W
authors.lastname: Marth
authors.affiliation: Institut für Wissenschaftliches Rechnen, TU Dresden, 01062 Dresden, Germany; Dresden Center for Computational Materials Science (DCMS), TU Dresden, 01062 Dresden, Germany; Center for Systems Biology Dresden (CSBD), Pfotenhauerstr. 108, 01307 Dresden, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Voigt
keywords: active polar gel theory; collective cell migration; hydrodynamic interactions