title: Comment on: "Cell therapy for heart disease: Trial sequential analyses of two cochrane reviews".
abstract: Trial Sequential Analysis (TSA) is a frequentist method to help researchers control the risks of random errors in meta-analyses.1Fisher et al.2used TSA on cell therapy for heart diseases. The present article discusses the usefulness of TSA and its dependence on the choice of the parameters for calculation of the required information size and the adjacent monitoring boundaries, and comments on the approach by Fisher et al.2.
authors.affiliation: Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.|Unit of Clinical Epidemiology, I.R.C.C.S. Orthopedic Institute Galeazzi, Milan, Italy.|The Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen, Denmark.
authors.forename: G
authors.initials: G
authors.lastname: Castellini
authors.affiliation: The Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen, Denmark.
authors.forename: E E
authors.initials: EE
authors.lastname: Nielsen
authors.affiliation: The Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen, Denmark.
authors.forename: C
authors.initials: C
authors.lastname: Gluud
mesh_terms: D064987:Cell- and Tissue-Based Therapy; D006331:Heart Diseases; D006801:Humans