title: Engineering Protein Self-Assembly: A New Approach for the Design of Octahedral Cages.
abstract: A new symmetry-based approach allowed the self-assembly of an octahedral protein nanostructure. C3trimeric and C4tetrameric oligomerization domains can be combined in an engineered protein to direct assembly into a desired object. This work might provide the basis for a more general and flexible strategy to control protein self-assembly.
authors.affiliation: Department of Organic Chemistry, University of Geneva, 30, Quai Ernest-Ansermet, 1211, Geneva 4, Switzerland.
authors.forename: Fabien B L
authors.identifier: http://orcid.org/0000-0003-4487-8707
authors.initials: FB
authors.lastname: Cougnon
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D004950:Esterases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015202:Protein Engineering; D020836:Protein Structure, Quaternary; D011506:Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D016958:Pseudomonas putida / Q000201:enzymology
chemical_list: D001426:Bacterial Proteins; D011506:Proteins; D004950:Esterases
keywords: enzyme catalysis; nanotechnology; protein engineering; self-assembly; symmetry