title: Outcomes of topography-guided versus wavefront-optimized laser in situ keratomileusis for myopia in virgin eyes.
abstract: To compare the outcomes of topography-guided and wavefront-optimized treatment in patients having laser in situ keratomileusis (LASIK) for myopia.
  
  
  
  Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
  
  
  
  Prospective contralateral-eye case study.
  
  
  
  Patients had topography-guided LASIK in 1 eye and wavefront-optimized LASIK in the contralateral eye using the Customized Refractive Surgery Master software and Mel 80 excimer laser. Refractive (residual manifest refraction spherical equivalent [MRSE], higher-order aberrations [HOAs]), and visual (uncorrected distance visual acuity [UDVA] and photopic and mesopic contrast sensitivity) outcomes were prospectively analyzed 6 months postoperatively.
  
  
  
  The study comprised 35 patients. The UDVA was 0.0 logMAR or better and the postoperative residual MRSE was ±0.50 diopter in 94.29% of eyes in the topography-guided group and 85.71% of eyes in the wavefront-optimized group (P = .09). More eyes in the topography-guided group than in the wavefront-optimized group had a UDVA of -0.1 logMAR or better (P = .04). Topography-guided LASIK was associated with less deterioration of mesopic contrast sensitivity at higher spatial frequencies (12 cycles per degree [cpd] and 18 cpd) and lower amounts of induced coma (P = .04) and spherical aberration (P = .04). Less stromal tissue was ablated in the topography-guided group (mean 61.57 μm ± 16.23 [SD]) than in the wavefront-optimized group (mean 79.71 ± 14.81 μm) (P < .001).
  
  
  
  Although topography-guided LASIK and wavefront-optimized LASIK gave excellent results, topography-guided LASIK was associated with better contrast sensitivity, lower induction of HOAs, and a smaller amount of tissue ablation.
  
  
  
  None of the authors has a financial or proprietary interest in any material or method mentioned.
authors.affiliation: From the Advanced Eye Centre (Jain, Malhotra, Parasi, Kumar), Post Graduate Institute of Medical Education and Research, Chandigarh, India; the Department of Ophthalmology (Moshirfar), Francis I. Proctor Foundation, University of California San Francisco, San Francisco, California, USA. Electronic address: aronkjain@yahoo.com.
authors.forename: Arun Kumar
authors.initials: AK
authors.lastname: Jain
authors.affiliation: From the Advanced Eye Centre (Jain, Malhotra, Parasi, Kumar), Post Graduate Institute of Medical Education and Research, Chandigarh, India; the Department of Ophthalmology (Moshirfar), Francis I. Proctor Foundation, University of California San Francisco, San Francisco, California, USA.
authors.forename: Chintan
authors.initials: C
authors.lastname: Malhotra
authors.affiliation: From the Advanced Eye Centre (Jain, Malhotra, Parasi, Kumar), Post Graduate Institute of Medical Education and Research, Chandigarh, India; the Department of Ophthalmology (Moshirfar), Francis I. Proctor Foundation, University of California San Francisco, San Francisco, California, USA.
authors.forename: Anand
authors.initials: A
authors.lastname: Pasari
authors.affiliation: From the Advanced Eye Centre (Jain, Malhotra, Parasi, Kumar), Post Graduate Institute of Medical Education and Research, Chandigarh, India; the Department of Ophthalmology (Moshirfar), Francis I. Proctor Foundation, University of California San Francisco, San Francisco, California, USA.
authors.forename: Pawan
authors.initials: P
authors.lastname: Kumar
authors.affiliation: From the Advanced Eye Centre (Jain, Malhotra, Parasi, Kumar), Post Graduate Institute of Medical Education and Research, Chandigarh, India; the Department of Ophthalmology (Moshirfar), Francis I. Proctor Foundation, University of California San Francisco, San Francisco, California, USA.
authors.forename: Majid
authors.initials: M
authors.lastname: Moshirfar
mesh_terms: D001251:Astigmatism; D057108:Corneal Wavefront Aberration; D006801:Humans; D007194:India; D020731:Keratomileusis, Laser In Situ; D054018:Lasers, Excimer; D009216:Myopia / Q000601:surgery*; D011446:Prospective Studies; D012029:Refraction, Ocular; D016896:Treatment Outcome