title: Product Control using Substrate Design: Ruthenium-Catalysed Oxidative C-H Olefinations of Cyclic Weinreb Amides.
abstract: A new class of Weinreb amides has been developed as directing groups for the ruthenium-catalysed regioselective oxidative C-H olefination. The new Weinreb amides successfully inhibit the N-O bond reductive cleavage usually associated with the cationic ruthenium system, thereby keeping intact the synthetic utility of Weinreb amides. Mechanistic studies reveal interesting aspects of the directing group capabilities of Weinreb amides when compared to simple amides of similar structures.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhauri, Bhopal, 462066, MP, India.
authors.forename: Riki
authors.initials: R
authors.lastname: Das
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhauri, Bhopal, 462066, MP, India.
authors.forename: Manmohan
authors.initials: M
authors.lastname: Kapur
keywords: C−H activation; C−H functionalization; Weinreb amides; oxidative-Heck; ruthenium