title: Neuropeptide Y accelerates post-fracture bone healing by promoting osteogenesis of mesenchymal stem cells.
abstract: Fracture repair is a complex yet well orchestrated regenerative process involving numerous signaling and cell types including osteoblasts. Here we showed that NPY, a neurotransmitter with regulatory functions in bone homeostasis, may contribute to the post-fracture bone healing in patients with traumatic brain injury-fracture combined injuries. Our results suggested NPY levels were increased in patients with the combined injuries, accomplished by arising of bone healing markers, such as ALP, OC, PICP and ICTP, than in those with simple fractures, and NPY have direct actions on MSCs to promote their osteogenic differentiation. Our results provided clinical evidences for NPY participating in the bone healing process in a nonhypothalamic manner, most probably by directly promoting osteogenesis of mesenchymal stem cells.
authors.affiliation: Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Xiao-Chuan
authors.initials: XC
authors.lastname: Gu
authors.affiliation: Department of Emergency Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Zhang
authors.affiliation: Department of Medical Oncology, Shanghai Minhang District Hospital of Traditional Chinese Medicine, Shanghai, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Hu
authors.affiliation: Department of Emergency, 463rd Hospital of PLA, Shenyang 110042, China. Electronic address: ziying008@hotmail.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zi
authors.affiliation: Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China. Electronic address: limingch@21cn.com.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002454:Cell Differentiation / Q000187:drug effects*; D024042:Collagen Type I / Q000097:blood; D005260:Female; D017102:Fracture Healing / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects*; D008875:Middle Aged; D009478:Neuropeptide Y / Q000097:blood* / Q000494:pharmacology; D015675:Osteocalcin / Q000097:blood; D010012:Osteogenesis / Q000187:drug effects*; D010455:Peptides / Q000097:blood; D012887:Skull Fractures / Q000097:blood* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D009478:Neuropeptide Y; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D000469:Alkaline Phosphatase
keywords: Bone healing; Fracture; MSCs; NPY