title: Role of the renal sympathetic nerves in renal sodium/potassium handling and renal damage in spontaneously hypertensive rats.
abstract: Renal sympathetic nerve activity has an important role in renal disease-associated hypertension and in the modulation of fluid homeostasis. In the present study, changes in renal function and renal sodium/potassium handling were investigated in groups of 12-week-old male, spontaneously hypertensive rats with renal denervation (RDNX group) or sham denervation (sham group). The RDNX group excreted significantly more sodium than the sham group during the 2-week observation period (P<0.05). Following bilateral renal denervation, the fractional lithium excretion was elevated in the RDNX group compared with the sham group, but no significant effect was observed of renal denervation on the fractional distal reabsorption rate of sodium or the fractional excretion of potassium. Furthermore, the glomerular injury score and the wall-to-lumen ratio of the interlobular artery were significantly lower in the RDNX group than in the sham group (P<0.05). In conclusion, the present study indicates an involvement of the renal sympathetic nerves in the regulation of renal tubular sodium reabsorption in spontaneously hypertensive rats and in the renal damage associated with hypertension.
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
authors.forename: Jianling
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Pharmacology, Affiliated Hospital of Guangxi Medical University, The First People's Hospital of Nanning, Nanning, Guangxi 530000, P.R. China.
authors.forename: Qiaoling
authors.initials: Q
authors.lastname: He
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
authors.forename: Weifeng
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
authors.forename: Qingjie
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
authors.forename: Rongjie
authors.initials: R
authors.lastname: Huang
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Pan
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
authors.forename: Wenying
authors.initials: W
authors.lastname: Lai
keywords: hypertension; renal denervation; renal function; renal sodium/potassium handling; sympathetic nerve activity