title: Ewing sarcoma family of tumors in children younger than 10 years of age.
abstract: Few data exist regarding the clinical characteristics and outcome of young children with Ewing sarcoma family of tumors (ESFT).
  
  
  
  We reviewed the records of ESFT patients at our institution younger than 10 years of age at diagnosis.
  
  
  
  Forty-two patients were identified. Median age was 6.4 years (range 0.6-9.5 years). Most patients had T2 (>5 cm) tumors (n = 31; 74%). Most common primary site was the extremity (n = 17; 41%). Seven patients (17%) had metastasis at diagnosis. For local tumor control, 20 patients had surgery only, 13 had radiation therapy only, and 6 had surgery plus radiation. Surgical margin status was negative in 19 patients (73%). Median follow-up was 4.7 years (range 0.7-29.7 years), and 5-year relapse-free survival (RFS) and overall survival (OS) estimates were 67% (95% CI: 53-84%) and 82% (95% CI: 71-95%), respectively. Metastasis at presentation was the only significant predictor for decreased RFS (P = 0.008) and OS (P = 0.01). A trend was seen for T2 tumors with worse OS (P = 0.09).
  
  
  
  Patients younger than 10 years of age with ESFT may have a better OS than older patients, but further study of a homogeneously treated larger cohort is needed.
authors.affiliation: Division of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, Texas.
authors.forename: Winston W
authors.initials: WW
authors.lastname: Huh
authors.affiliation: Division of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, Texas.
authors.forename: Najat C
authors.initials: NC
authors.lastname: Daw
authors.affiliation: Division of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, Texas.
authors.forename: Cynthia E
authors.initials: CE
authors.lastname: Herzog
authors.affiliation: Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas.
authors.forename: Mark F
authors.initials: MF
authors.lastname: Munsell
authors.affiliation: Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.
authors.forename: Mary Frances
authors.initials: MF
authors.lastname: McAleer
authors.affiliation: Division of Orthopedic Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.
authors.forename: Valerae O
authors.initials: VO
authors.lastname: Lewis
mesh_terms: D001859:Bone Neoplasms / Q000556:secondary / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008207:Lymphatic Metastasis; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D012512:Sarcoma, Ewing / Q000473:pathology / Q000628:therapy*; D015996:Survival Rate
keywords: Ewing sarcoma; bone; childhood cancer; pediatric; sarcoma; solid tumor