title: Performing Aspirin Desensitization in Aspirin-Exacerbated Respiratory Disease.
abstract: Aspirin-exacerbated respiratory disease (AERD) is characterized by chronic rhinosinusitis with nasal polyps, asthma, and reactions to cyclooxygenase-1-inhibiting drugs. This condition is often refractory to standard medical treatments and results in aggressive nasal polyposis that often requires multiple sinus surgeries. Aspirin desensitization followed by daily aspirin therapy is an important treatment option, and its efficacy has been validated in multiple research studies. Aspirin desensitization is not without risk, but specific protocols and recommendations exist to mitigate the risk. Most patients with AERD can undergo aspirin desensitization in an outpatient setting under the supervision of an allergist.
authors.affiliation: Department of Allergy and Immunology, Scripps Clinic Carmel Valley, Scripps Clinic, 3811 Valley Centre Drive, Suite 4A, San Diego, CA 92130, USA.
authors.forename: Jeremy D
authors.initials: JD
authors.lastname: Waldram
authors.affiliation: Department of Allergy and Immunology, Scripps Clinic Carmel Valley, Scripps Clinic, 3811 Valley Centre Drive, Suite 4A, San Diego, CA 92130, USA. Electronic address: Simon.ronald@scrippshealth.org.
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Simon
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D003888:Desensitization, Immunologic / Q000009:adverse effects / Q000379:methods; D003948:Diagnostic Techniques, Respiratory System; D019468:Disease Management; D006801:Humans; D012129:Respiratory Function Tests; D012140:Respiratory Tract Diseases / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin
keywords: AERD; AERD diagnosis; AERD treatment; Aspirin; Desensitization