title: Polydopamine Nanoparticles Modulating Stimuli-Responsive PNIPAM Hydrogels with Cell/Tissue Adhesiveness.
abstract: Stimuli-responsive hydrogels can respond to stimuli by phase transformation or volume change and exhibit specific functions. Near-infrared (NIR)-responsive hydrogel is a type of stimuli-responsive hydrogel, which can be precisely controlled by altering the radiation intensity, exposure time of the light source, and irradiation sites. Here, polydopamine nanoparticles (PDA-NPs) were introduced into a poly(N-isopropylacrylamide) (PNIPAM) network to fabricate a PDA-NPs/PNIPAM hydrogel with NIR responsibility, self-healing ability, and cell/tissue adhesiveness. After incorporation of PDA-NPs into the hydrogel, the PDA-NPs/PNIPAM hydrogel showed phase transitions and volume changes in response to NIR. Thus, the hydrogel can achieve triple response effects, including pulsatile drug release, NIR-driven actuation, and NIR-assisted healing. After coating PDA-NPs onto hydrogel surfaces, the hydrogel showed improved cell affinity, good tissue adhesiveness, and growth factor/protein immobilization ability because of reactive catechol groups on PDA-NPs. The tissue adhesion strength to porcine skin was as high as 90 KPa. In vivo full-skin defect experiments demonstrated that PDA-NPs coating on the hydrogel and an immobilized growth factor had a synergistic effect on accelerating wound healing. In summary, we combined thermosensitive PNIPAM and mussel-inspired PDA-NPs to form a NIR-responsive hydrogel, which may have potential applications for chemical and physical therapies.
authors.affiliation: Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University , Chengdu, 610031 Sichuan, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Han
authors.affiliation: Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University , Chengdu, 610031 Sichuan, China.
authors.forename: Yanning
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University , Chengdu, 610031 Sichuan, China.|National Engineering Research Center for Biomaterials, Genome Research Center for Biomaterials, Sichuan University , Chengdu, 610064 Sichuan, China.
authors.forename: Xiong
authors.initials: X
authors.lastname: Lu
authors.affiliation: National Engineering Research Center for Biomaterials, Genome Research Center for Biomaterials, Sichuan University , Chengdu, 610064 Sichuan, China.
authors.forename: Kefeng
authors.initials: K
authors.lastname: Wang
authors.affiliation: Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University , Chengdu, 610031 Sichuan, China.
authors.forename: Zhenming
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Engineering Research Center of Biomass Materials, Ministry of Education, School of Materials Science and Engineering, Southwest University of Science and Technology , Mianyang 621010, China.
authors.forename: Hongping
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000180:Acrylic Resins; D020100:Hydrogels; D007211:Indoles; D053758:Nanoparticles; D011108:Polymers; D014014:Tissue Adhesives
chemical_list: D000180:Acrylic Resins; D020100:Hydrogels; D007211:Indoles; D011108:Polymers; D014014:Tissue Adhesives; C568283:polydopamine; C052970:poly-N-isopropylacrylamide
keywords: NIR-responsive; adhesive; hydrogel; poly(N-isopropylacrylamide); polydopamine nanoparticles