title: [Definitions destruction of endothelial cells as a marker of endothelial dysfunction in aging men].
abstract: BACKGROUND
  Ukraine occupies the 143 place in the world in life expectancy and the first place in terms of mortality. The main cause of death - cardiovascular diseases - 58%. Recent studies show the important and independent role of endothelium in the development of cardiovascular disease.
  
  
  OBJECTIVE
  examination of the endothelium destruction in aging men by determining the level of surface specific antigens of endothelial microparticles.
  
  
  METHODS
  88 men age from 45 to 76 years. 50 people of the main group had a history of the second type diabetes mellitus (DM-2) combined with arterial hypertension (AH). The control group included 38 men without aforementioned diseases. Also, men were divided into two groups by age: 45-59 years and over 60.
  
  
  RESULTS
  in the main subgroup I endothelin level was higher than the control subgroup I: 2,07 ± 0,6 and 1,27 ± 0,25 (p <0.05). In main subgroup II endothelin level was also significantly higher compared with the specified index in control subgroup II: 3,91 ± 0,7 and 1,79 ± 0,27 (p <0.05). Among patients of the main subgroup II endothelin level (3,88 ± 0,7 and 2,04 ± 0,6 (p <0.05)), and triglycerides (2,77 ± 0,08 vs. 1.99 ± 0.05 (p <0.05)) was higher compared with the I subgroup.
  
  
  CONCLUSIONS
  age androgen deficiency is accompanied by lipid metabolism, development of endothelial dysfunction, insulin resistance, diabetes and hypertension. Reduction of the cardiovascular risk includes measures aimed at normalizing hormonal balance and lipid metabolism in aging men with DM-2 and hypertension.
authors.affiliation: Вищий державний навчальний заклад України ≪Українська медична стоматологічна академія ≫, Полтава, Україна.
authors.forename: Ганна Л
authors.initials: ГЛ
authors.lastname: Пустовойт
authors.affiliation: Вищий державний навчальний заклад України ≪Українська медична стоматологічна академія ≫, Полтава, Україна.
authors.forename: Тетяна І
authors.initials: ТІ
authors.lastname: Ярмола
authors.affiliation: Вищий державний навчальний заклад України ≪Українська медична стоматологічна академія ≫, Полтава, Україна.
authors.forename: Олександр В
authors.initials: ОВ
authors.lastname: Мохначов
authors.affiliation: Вищий державний навчальний заклад України ≪Українська медична стоматологічна академія ≫, Полтава, Україна.
authors.forename: Лідія А
authors.initials: ЛА
authors.lastname: Ткаченко
authors.affiliation: Вищий державний навчальний заклад України ≪Українська медична стоматологічна академія ≫, Полтава, Україна.
authors.forename: Сергій М
authors.initials: СМ
authors.lastname: Супруненко
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000473:pathology*; D016232:Endothelins / Q000097:blood; D004730:Endothelium, Vascular / Q000473:pathology*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood; D014455:Ukraine
chemical_list: D015415:Biomarkers; D016232:Endothelins; D014280:Triglycerides
keywords: diabetes; hypertension; markers of endothelium destruction