title: Preparation and in vitro characterization of solid dispersion floating tablet by effervescent control release technique with improved floating capabilities.
abstract: In this Research, an effort has been done for the development of effervescent controlled release floating tablet (ECRFT) from solid dispersions (SDs) of diclofenac sodium (DS) for upsurge the solubility and dissolution rate. ECRFT of DS was prepared by using SDs of DS and its SDs prepared with PEG as carrier using thermal method (Simple fusion). SDs of DS were formulated in many ratio (1:1, 1:2, 1:3 and 1:4). Prepared SDs was optimized for its solubility, % drug content and % dissolution studies. Tablets were formulated by using optimized SDs products and all formulation was evaluated for various parameters. A clear rise in dissolution rate was detected with entirely SD, amid that the optimized SD (SD4) was considered for ECRFT. Among all the tablet formulations, its F3 formulation was better in all the terms of pre compression and post compression parameters. It had all the qualities of a good ECRFT, based on this F3 formulation was selected as the best formulation. Data of in vitro release was fitted in several kinetics models to explain release mechanism. The F3 formulation shows zero order release. From this study we can concluded that ECRFT containing SDs of DS can be successfully used for achieving better therapeutic objective.
authors.affiliation: Department of Pharmaceutical Sciences (FAMS), Gurukul Kangri University, Haridwar, India.
authors.forename: Peeush
authors.initials: P
authors.lastname: Singhal
authors.affiliation: Department of Pharmaceutical Sciences (FAMS), Gurukul Kangri University, Haridwar, India.
authors.forename: Rajneesh Dutt
authors.initials: RD
authors.lastname: Kaushik
authors.affiliation: Department of Pharmaceutical Sciences, H.N.B. Garhwal Central University, Srinagar, Uttarakhand, India.
authors.forename: Vijay Jyoti
authors.initials: VJ
authors.lastname: Kumar
authors.affiliation: School of Pharmaceutical Sciences, IFTM University, Lodhipur Rajput, NH-24, Delhi Road, Moradabad, UP, India.
authors.forename: Anurag
authors.initials: A
authors.lastname: Verma
authors.affiliation: College of Pharmacy and Health Science, St. John's University, New York, USA.
authors.forename: Pranav
authors.initials: P
authors.lastname: Gupta
mesh_terms: D016861:Cyclooxygenase Inhibitors / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004008:Diclofenac / Q000737:chemistry*; D004337:Drug Carriers; D004339:Drug Compounding; D004355:Drug Stability; D007700:Kinetics; D008956:Models, Chemical; D011092:Polyethylene Glycols / Q000737:chemistry*; D012995:Solubility; D013607:Tablets; D014867:Water / Q000737:chemistry*
chemical_list: D016861:Cyclooxygenase Inhibitors; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D013607:Tablets; D014867:Water; D004008:Diclofenac; D011092:Polyethylene Glycols