title: Correlation of clinical, laboratory and drug susceptibility profiles in 176 patients with culture positive TBM in a tertiary neurocare centre.
abstract: Drug resistance has increased the difficulties in control of tuberculosis infection. The present study evaluated the clinical and laboratory features among tuberculous meningitis (TBM) patients and the drug susceptibility of Mycobacterium tuberculosis (M.tb) isolated from CSF. Out of 698 CSF samples, 176 (25.21%) were M.tb culture positive. Among the clinical signs and symptoms, fever, headache and altered sensorium were found to be statistically significant (P<0.05). ELISA was a better predictor of disease and found to be statistically significant (P<0.001) in culture-proven TBM cases. Totally, 57 (32.4%) isolates were resistant to one or more drugs that include 5 (2.8%) multidrug-resistant isolates. In conclusion, the search for antibody in CSF and also CSF chloride can represent as an adjunct in the diagnosis of TBM. Screening of drug susceptibility is a very important factor and would help in better management of the disease.
authors.affiliation: Department of Neuromicrobiology, National Institute of Mental Health and Neuroscience, Hosur Road, Bengaluru, Karnataka 560029, India.
authors.forename: Kavitha
authors.initials: K
authors.lastname: Kumar
authors.affiliation: Department of Neuromicrobiology, National Institute of Mental Health and Neuroscience, Hosur Road, Bengaluru, Karnataka 560029, India.
authors.forename: Prashant
authors.initials: P
authors.lastname: Giribhattanavar
authors.affiliation: Department of Neuromicrobiology, National Institute of Mental Health and Neuroscience, Hosur Road, Bengaluru, Karnataka 560029, India.
authors.forename: Nagarathna
authors.initials: N
authors.lastname: Chandrashekar
authors.affiliation: Department of Neuromicrobiology, National Institute of Mental Health and Neuroscience, Hosur Road, Bengaluru, Karnataka 560029, India. Electronic address: shripadpatil@yahoo.com.
authors.forename: Shripad
authors.initials: S
authors.lastname: Patil
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000134:cerebrospinal fluid; D000995:Antitubercular Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D002555:Cerebrospinal Fluid / Q000276:immunology / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification; D011446:Prospective Studies; D016896:Treatment Outcome; D014390:Tuberculosis, Meningeal / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology*; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D000995:Antitubercular Agents
keywords: Cerebrospinal fluid; Culture; Diagnosis; Drug resistance; Immunoassay; Mycobacteria