title: AuNP-Collagen Matrix with Localized Stiffness for Cardiac-Tissue Engineering: Enhancing the Assembly of Intercalated Discs by β1-Integrin-Mediated Signaling.
abstract: A schematic for the mechanism of accelerating the assembly of intercalated discs (IDs) in cardiac myocytes regulated by gold nanoparticles (AuNPs) is presented. AuNPs with local nanoscale stiffness in the substrate activate β1-integrin signaling, which mediates the activation of integrin-linked kinase (ILK) and its downstream signal kinase by stimulating expression of the transcription factors GATA4 and MEF-2c.
authors.affiliation: Department of Cardiology, The General Hospital of Chinese People's Armed Police Forces, Beijing, 100039, P. R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, P. R. China.|School of Future Technology, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Shi
authors.affiliation: Department of Cardiology, The General Hospital of Chinese People's Armed Police Forces, Beijing, 100039, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Tian
authors.affiliation: Chengdu Military General Hospital, Chengdu, Sichuan Province, 610083, P. R. China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Sun
authors.affiliation: Department of Cardiology, The General Hospital of Chinese People's Armed Police Forces, Beijing, 100039, P. R. China.
authors.forename: Yujing
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Affiliated Hospital of Academy of Military Medical Sciences, Beijing, 100071, P. R. China.
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, P. R. China.|School of Future Technology, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Cardiology, The General Hospital of Chinese People's Armed Police Forces, Beijing, 100039, P. R. China.
authors.forename: Yujie
authors.initials: Y
authors.lastname: Wei
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, P. R. China.|School of Future Technology, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
authors.forename: Xinxiao
authors.initials: X
authors.lastname: Han
authors.affiliation: Department of Cardiology, The General Hospital of Chinese People's Armed Police Forces, Beijing, 100039, P. R. China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, The General Hospital of Chinese People's Armed Police Forces, Beijing, 100039, P. R. China.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Jia
authors.affiliation: Department of Cardiology, The General Hospital of Chinese People's Armed Police Forces, Beijing, 100039, P. R. China.
authors.forename: Rui
authors.initials: R
authors.lastname: Bai
authors.affiliation: Department of Cardiology, The General Hospital of Chinese People's Armed Police Forces, Beijing, 100039, P. R. China.
authors.forename: Limin
authors.initials: L
authors.lastname: Jing
authors.affiliation: Department of Cardiology, The General Hospital of Chinese People's Armed Police Forces, Beijing, 100039, P. R. China.
authors.forename: Peng
authors.initials: P
authors.lastname: Ding
authors.affiliation: Department of Cardiology, The General Hospital of Chinese People's Armed Police Forces, Beijing, 100039, P. R. China.
authors.forename: Huiliang
authors.initials: H
authors.lastname: Liu
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, P. R. China.|School of Future Technology, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
authors.forename: Dong
authors.initials: D
authors.lastname: Han
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003094:Collagen / Q000378:metabolism*; D050991:GATA4 Transcription Factor / Q000378:metabolism; D006046:Gold / Q000737:chemistry*; D019012:Integrin beta1 / Q000378:metabolism*; D064326:MEF2 Transcription Factors / Q000378:metabolism; D053768:Metal Nanoparticles / Q000737:chemistry*; D032383:Myocytes, Cardiac / Q000166:cytology* / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*; D000099200:Scaffold Protein ILK
chemical_list: D003094:Collagen; D050991:GATA4 Transcription Factor; D006046:Gold; D019012:Integrin beta1; D064326:MEF2 Transcription Factors; D017346:Protein Serine-Threonine Kinases; D000099200:Scaffold Protein ILK; C084365:Gata4 protein, rat; C578042:MEF2C protein, rat
keywords: cardiac-tissue engineering; gold nanoparticles; intercalated discs; localized stiffness; β1-integrin