title: In vivo antinociceptive and muscle relaxant activity of leaf and bark of Buddleja asiatica L.
abstract: The current study was designed to assess the antinociceptive and skeleton muscle relaxant effect of leaves and barks of Buddleja asiatica in animal models. In acetic acid induced writhing test, pretreatment of ethanolic extract of leaves and barks evoked marked dose dependent antinociceptive effect with maximum of 70% and 67% pain relief at 300mg/kg i.p. respectively. In chimney test, the ethanolic extract of leaves and barks evoked maximum of 66.66% and 53.33% muscle relaxant effect after 90min of treatment at 300mg/kg i.p respectively. In traction test, the ethanolic extract of leaves and barks caused maximum of 60% and 73.33% muscle relaxant effect after 90min of treatment at 300mg/kg i.p respectively. In short, both leaves and barks demonstrated profound antinociceptive and skeleton muscle relaxant effects and thus the study provided natural healing agents for the treatment of said disorders.
authors.affiliation: Department of Botany Islamia College, University of Peshawar, KPK, Pakistan.
authors.forename: -
authors.initials: -
authors.lastname: Barkatullah
authors.affiliation: Department of Botany University of Peshawar, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ibrar
authors.affiliation: Department of Botany University of Peshawar, Pakistan.
authors.forename: Nazia
authors.initials: N
authors.lastname: Ikram
authors.affiliation: Department of Geology, University of Swabi, KPK, Pakistan.
authors.forename: Abdur
authors.initials: A
authors.lastname: Rauf
authors.affiliation: LCM Laboratory, University of Mohamed 1st, Faculty of Sciences, Oujda 60000, Morocco.
authors.forename: Taibi Ben
authors.initials: TB
authors.lastname: Hadda
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, Makkah, P.O. Box 42, Saudi Arabia.
authors.forename: Saud
authors.initials: S
authors.lastname: Bawazeer
authors.affiliation: Department of pharmacy, Abdul Wali Khan University Mardan, Pakistan.
authors.forename: Haroon
authors.initials: H
authors.lastname: Khan
authors.affiliation: Gandhara College of Pharmacy, Gandhara University, Peshawar, Pakistan.
authors.forename: Samreen
authors.initials: S
authors.lastname: Pervez
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D032861:Buddleja / Q000737:chemistry; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000737:chemistry; D005260:Female; D008297:Male; D008807:Mice, Inbred BALB C; D009126:Muscle Relaxation / Q000187:drug effects*; D018482:Muscle, Skeletal / Q000187:drug effects*; D009465:Neuromuscular Agents / Q000302:isolation & purification / Q000494:pharmacology*; D059226:Nociceptive Pain / Q000139:chemically induced / Q000517:prevention & control*; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves; D010946:Plants, Medicinal; D012997:Solvents / Q000737:chemistry; D013997:Time Factors
chemical_list: D000700:Analgesics; D009465:Neuromuscular Agents; D010936:Plant Extracts; D012997:Solvents; D000431:Ethanol; D019342:Acetic Acid