title: Effect of Potassium Comenate on CNS Functional Status in Rodents Exposed to Combined Hypoxia and Hypercapnia in Comparison with Normally Ventilated Animals.
abstract: The effects of potassium comenate on functional state of CNS in mice and rats were studied in the open-field and hole-board tests under control conditions and after acute exposure to hypoxia-hypercapnia. The effects of potassium comenate on CNS were also studied in rodents subjected to propofol-induced sleep. Preliminary administration of 4 mg/kg potassium comenate for 3 days attenuated the posthypoxic changes in behavioral reactions (emotional anxiety/reactivity). The pronounced stress-protective effect of potassium comenate was observed both on days 1 and 14 after exposure to hypoxia-hypercapnia. Under normal conditions, potassium comenate moderated behavioral reactions and augmented somniferous effect of propofol. We hypothesized that the antihypoxic effect of potassium comenate is determined by its stress-protective and sedative potencies.
authors.affiliation: A. Ya. Shurygin Department of Biologically Active Substances, Kuban State University, Krasnodar, Russia. balizfarm@mail.ru.
authors.forename: L V
authors.initials: LV
authors.lastname: Shurygina
authors.affiliation: A. Ya. Shurygin Department of Biologically Active Substances, Kuban State University, Krasnodar, Russia.
authors.forename: E I
authors.initials: EI
authors.lastname: Zlishcheva
authors.affiliation: A. Ya. Shurygin Department of Biologically Active Substances, Kuban State University, Krasnodar, Russia.
authors.forename: T V
authors.initials: TV
authors.lastname: Androsova
authors.affiliation: Baliz Farm, Krasnodar, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Nemchinova
authors.affiliation: A. Ya. Shurygin Department of Biologically Active Substances, Kuban State University, Krasnodar, Russia.
authors.forename: A N
authors.initials: AN
authors.lastname: Kravtsova
mesh_terms: D000818:Animals; D001007:Anxiety; D002264:Carboxylic Acids / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005106:Exploratory Behavior / Q000187:drug effects*; D006935:Hypercapnia / Q000188:drug therapy* / Q000523:psychology; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D000860:Hypoxia / Q000188:drug therapy* / Q000523:psychology; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology*; D015742:Propofol / Q000494:pharmacology; D011753:Pyrones / Q000494:pharmacology*; D017208:Rats, Wistar; D012890:Sleep / Q000187:drug effects
chemical_list: D002264:Carboxylic Acids; D006993:Hypnotics and Sedatives; D018696:Neuroprotective Agents; D011753:Pyrones; C488376:comenic acid; D015742:Propofol
keywords: behavioral reactions; hypoxia–hypercapnia; normal conditions; potassium comenate; propofol