title: Recent advances in mass spectrometry-based proteomics of gastric cancer.
abstract: The last decade has witnessed remarkable technological advances in mass spectrometry-based proteomics. The development of proteomics techniques has enabled the reliable analysis of complex proteomes, leading to the identification and quantification of thousands of proteins in gastric cancer cells, tissues, and sera. This quantitative information has been used to profile the anomalies in gastric cancer and provide insights into the pathogenic mechanism of the disease. In this review, we mainly focus on the advances in mass spectrometry and quantitative proteomics that were achieved in the last five years and how these up-and-coming technologies are employed to track biochemical changes in gastric cancer cells. We conclude by presenting a perspective on quantitative proteomics and its future applications in the clinic and translational gastric cancer research.
authors.affiliation: Changwon Kang, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, South Korea.
authors.forename: Changwon
authors.initials: C
authors.lastname: Kang
authors.affiliation: Changwon Kang, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, South Korea.
authors.forename: Yejin
authors.initials: Y
authors.lastname: Lee
authors.affiliation: Changwon Kang, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, South Korea.
authors.forename: J Eugene
authors.initials: JE
authors.lastname: Lee
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D045744:Cell Line, Tumor; D006801:Humans; D007554:Isotopes; D013058:Mass Spectrometry; D011499:Protein Processing, Post-Translational; D020543:Proteome; D040901:Proteomics; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000503:physiopathology*; D057170:Translational Research, Biomedical
chemical_list: D014408:Biomarkers, Tumor; D007554:Isotopes; D020543:Proteome
keywords: Gastric cancer; Mass spectrometry; Protein identification; Protein quantification; Proteomics