title: CSF tau correlates with the degree of cortical involvement in E200K familial Creutzfeldt-Jakob disease.
abstract: Cerebrospinal fluid (CSF) tau was found to correlate with disease severity and cognitive status in E200K familial Creutzfeldt-Jakob disease (fCJD) patients. The objective of the present study was to test whether tau levels in the CSF also correlate with the disease burden as reflected by the degree of cortical involvement in DWI MRI. Forty-four consecutive E200K fCJD patients (25 males, mean age 58.6±7.5, range 48-75 years) were recruited to the study and had a CSF tau examination as well as measurements of the extent of the cortical involvement in the DWI axial MRI. Correlation was tested using Pearson test. A significant correlation (r=0.617 p<0.0001) was found between CSF tau levels and the extent of cortical involvement. This correlation between tau levels and the disease burden reinforce the notion that tau can be used as a biomarker reflecting the extent of disease in patients with E200K fCJD.
authors.affiliation: Department of Neurology, Assaf Harofeh Medical Center, Zerifin, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address: coheno@asaf.health.gov.il.
authors.forename: Oren S
authors.initials: OS
authors.lastname: Cohen
authors.affiliation: Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Department of Neurology, Chaim Sheba Medical Center, Tel-Hashomer, Israel; Robert and Martha Harden Chair in Mental and Neurological Diseases, Sackler Faculty of Medicine, Tel Aviv University, Israel.
authors.forename: Joab
authors.initials: J
authors.lastname: Chapman
authors.affiliation: Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Amos D
authors.initials: AD
authors.lastname: Korczyn
authors.affiliation: St. George's University of London, Cyprus.
authors.forename: Oliver L
authors.initials: OL
authors.lastname: Siaw
authors.affiliation: Department of Neurology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: Naama
authors.initials: N
authors.lastname: Warman-Alaluf
authors.affiliation: Department of Neurology, Barzilai Medical Center, Ashkelon, Israel.
authors.forename: Zeev
authors.initials: Z
authors.lastname: Nitsan
authors.affiliation: Department of Neurology, Barzilai Medical Center, Ashkelon, Israel.
authors.forename: Shmuel
authors.initials: S
authors.lastname: Appel
authors.affiliation: Department of Neurology, Barzilai Medical Center, Ashkelon, Israel.
authors.forename: Esther
authors.initials: E
authors.lastname: Kahana
authors.affiliation: Department of Neurology, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
authors.forename: Hanna
authors.initials: H
authors.lastname: Rosenmann
authors.affiliation: Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Department of Radiology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: Chen
authors.initials: C
authors.lastname: Hoffmann
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000134:cerebrospinal fluid; D002540:Cerebral Cortex / Q000473:pathology*; D007562:Creutzfeldt-Jakob Syndrome / Q000134:cerebrospinal fluid / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D015415:Biomarkers; D016875:tau Proteins
keywords: Creutzfeldt-Jakob disease; Disease severity; E200K mutation; MRI; Tau protein