title: Palladium-catalyzed Sonogashira coupling of amides: access to ynones via C-N bond cleavage.
abstract: The first palladium-catalyzed Sonogashira coupling of amides has been developed, which proceeds via a selective cleavage of the N-acylsaccharin C-N bond. Notably, the new approach employs N-acylsaccharins as coupling partners to give ynones in good to excellent yield. This protocol can be efficiently utilized in the synthesis of a broad array of ynones under low catalyst loading and Cu-free conditions.
authors.affiliation: College of Chemistry and Environment, South China Normal University, Guangzhou 510006, People's Republic of China. zhuoz@scnu.edu.cn.
authors.forename: Ming
authors.initials: M
authors.lastname: Cui
authors.affiliation: College of Chemistry and Environment, South China Normal University, Guangzhou 510006, People's Republic of China. zhuoz@scnu.edu.cn.
authors.forename: Hongxiang
authors.initials: H
authors.lastname: Wu
authors.affiliation: College of Chemistry and Environment, South China Normal University, Guangzhou 510006, People's Republic of China. zhuoz@scnu.edu.cn.
authors.forename: Junsheng
authors.initials: J
authors.lastname: Jian
authors.affiliation: College of Chemistry and Environment, South China Normal University, Guangzhou 510006, People's Republic of China. zhuoz@scnu.edu.cn.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, People's Republic of China.
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Chemistry, University of Idaho, Moscow, ID 83844-2343, USA.
authors.forename: Stelck
authors.initials: S
authors.lastname: Daniel
authors.affiliation: College of Chemistry and Environment, South China Normal University, Guangzhou 510006, People's Republic of China. zhuoz@scnu.edu.cn and Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, People's Republic of China.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Zeng