title: Glial and neuronal markers in cerebrospinal fluid in different types of multiple sclerosis.
abstract: In the present study, CSF concentrations of NFL, t-tau, p-tau, GFAP, S-100B, YKL-40, MCP-1, α-sAPP, β-sAPP, and Aβ38, Aβ40, Aβ42 were measured in 324 MS patients to test whether a correlation among the biomarkers exists and whether the profile of CSF biomarkers varies among the different types of MS. The CSF concentrations of NFL were significantly higher in RRMS while CSF concentrations of GFAP were higher in PPMS. CSF concentrations of NFL correlated with YKL-40 in CIS patients while CSF concentrations of GFAP correlated with YKL-40 in RRMS patients.
authors.affiliation: Joan XXIII University Hospital, Universitat Rovira i Virgili, Tarragona, Spain; Bellvitge University Hospital, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain. Electronic address: unitatem@bellvitgehospital.cat.
authors.forename: M Alba
authors.initials: MA
authors.lastname: Mañé-Martínez
authors.affiliation: Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Möndal, Sweden.
authors.forename: Bob
authors.initials: B
authors.lastname: Olsson
authors.affiliation: Bellvitge University Hospital, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Bau
authors.affiliation: Bellvitge University Hospital, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Elisabet
authors.initials: E
authors.lastname: Matas
authors.affiliation: Bellvitge University Hospital, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Álvaro
authors.initials: Á
authors.lastname: Cobo-Calvo
authors.affiliation: Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Möndal, Sweden.
authors.forename: Ulf
authors.initials: U
authors.lastname: Andreasson
authors.affiliation: Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Möndal, Sweden.
authors.forename: Kaj
authors.initials: K
authors.lastname: Blennow
authors.affiliation: Bellvitge University Hospital, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Lucia
authors.initials: L
authors.lastname: Romero-Pinel
authors.affiliation: Bellvitge University Hospital, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Sergio
authors.initials: S
authors.lastname: Martínez-Yélamos
authors.affiliation: Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Möndal, Sweden; Institute of Neurology, University College London, United Kingdom.
authors.forename: Henrik
authors.initials: H
authors.lastname: Zetterberg
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000134:cerebrospinal fluid; D000071451:Chitinase-3-Like Protein 1 / Q000134:cerebrospinal fluid*; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000134:cerebrospinal fluid*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D016900:Neurofilament Proteins / Q000134:cerebrospinal fluid*; D009457:Neuroglia / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D055815:Young Adult; D016875:tau Proteins / Q000134:cerebrospinal fluid
chemical_list: D015415:Biomarkers; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D005904:Glial Fibrillary Acidic Protein; D016900:Neurofilament Proteins; D016875:tau Proteins