title: Magnesium taurate prevents cataractogenesis via restoration of lenticular oxidative damage and ATPase function in cadmium chloride-induced hypertensive experimental animals.
abstract: Previously we found that hypertension potentiates the risk the cataractogenesis. In the present study, we investigated the protective effects of magnesium taurate (MgT) on hypertension and associated lenticular damages against cadmium chloride (CdCl2)-induced hypertensive animals. Male Sprague-Dawley albino rats (150-180g) were assigned to five experimental groups (n=6). Among the five groups, normal group received 0.3% carboxymethyl cellulose (10ml/kg/day, p.o.). Hypertension control group received CdCl2(0.5mg/kg/day, i.p.). Tests and standard groups received MgT (3 and 6mg/kg/day, p.o.) and amlodipine (3mg/kg/day, p.o.) concurrently with CdCl2respectively,for six consecutive weeks. Blood pressure, heart rate, and eyes were examined biweekly, and pathophysiological parameters in serum and eye lenses were evaluated after six weeks of the experimental protocol. The chronic administration of MgT concurrently with CdCl2significantly restored the blood pressure, serum and lens antioxidants (CAT, SOD, GPx, and GSH), MDA level, and ions (Na+, K+, and Ca2+). Additionally, MgT treatment led to significant increase in the lens proteins (total and soluble), Ca2+ATPase, and Na+K+ATPase activity as compared to hypertension control group. Ophthalmoscope observations indicated that MgT treatments delayed the progression of cataract against the hypertensive state. The study shows that MgT prevents the progression of cataractogenesis via restoration of blood pressure, lenticular oxidative damages, and lens ATPase functions in the hypertensive state. The results suggest that MgT supplement may play a beneficial role to manage hypertension and associated cataractogenesis.
authors.affiliation: Department of Pharmacology, Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, 495009, Chhattisgarh, India.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Choudhary
authors.affiliation: Department of Pharmacology, Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, 495009, Chhattisgarh, India. Electronic address: drbodakhe@gmail.com.
authors.forename: Surendra H
authors.initials: SH
authors.lastname: Bodakhe
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D019256:Cadmium Chloride; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D002386:Cataract / Q000097:blood / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control*; D018450:Disease Progression; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000097:blood / Q000473:pathology* / Q000503:physiopathology; D007477:Ions; D007908:Lens, Crystalline / Q000187:drug effects / Q000201:enzymology* / Q000473:pathology; D008274:Magnesium / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013599:Systole / Q000187:drug effects; D013654:Taurine / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D015415:Biomarkers; D007477:Ions; D013654:Taurine; D000251:Adenosine Triphosphatases; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase; D008274:Magnesium; D019256:Cadmium Chloride
keywords: Cadmium chloride; Cataract; Hypertension; Magnesium taurate; Oxidative stress