title: Ductal Breast Carcinoma Metastatic to the Stomach Resembling Primary Linitis Plastica in a Male Patient.
abstract: Breast cancer metastases to the gastrointestinal tract are very rare occurrences. Among the histological subtypes of breast cancer, invasive lobular carcinomas have a high capacity of metastasis to uncommon sites including the stomach. Conversely, there has not been sufficient evidence supporting the gastric metastasis of invasive ductal carcinoma. Herein, we report a unique case of metastatic ductal breast carcinoma mimicking primary linitis plastica in a male patient, particularly focusing on the clinical and pathological features of presentation. Moreover, we propose a immunohistochemical panel of selected antibodies including those for cytokeratin 20, cytokeratin 7, estrogen receptor, progesterone receptor, E-cadherin, gross cystic disease fluid protein 15, and GATA binding protein 3 for an accurate differential diagnosis.
authors.affiliation: Department of Medical Oncology, Santa Maria della Misericordia Hospital, Perugia, Italy.
authors.forename: Biagio
authors.initials: B
authors.lastname: Ricciuti
authors.affiliation: Department of Medical Oncology, Santa Maria della Misericordia Hospital, Perugia, Italy.
authors.forename: Giulia Costanza
authors.initials: GC
authors.lastname: Leonardi
authors.affiliation: Department of Medical Oncology, Santa Maria della Misericordia Hospital, Perugia, Italy.
authors.forename: Noemi
authors.initials: N
authors.lastname: Ravaioli
authors.affiliation: Department of Medical Oncology, Santa Maria della Misericordia Hospital, Perugia, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: De Giglio
authors.affiliation: Department of Medical Oncology, Santa Maria della Misericordia Hospital, Perugia, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Brambilla
authors.affiliation: Department of Experimental Medicine and Biochemical Sciences, Section of Anatomic Pathology and Histology, University of Perugia, Perugia, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Prosperi
authors.affiliation: Department of Diagnostic Cytology and Histology Unit, Santa Maria della Misericordia Hospital, University of Perugia, Perugia, Italy.
authors.forename: Franca
authors.initials: F
authors.lastname: Ribacchi
authors.affiliation: Department of Medical Oncology, Santa Maria della Misericordia Hospital, Perugia, Italy.
authors.forename: Marialuisa
authors.initials: M
authors.lastname: Meacci
authors.affiliation: Department of Medical Oncology, Santa Maria della Misericordia Hospital, Perugia, Italy.
authors.forename: Lucio
authors.initials: L
authors.lastname: Crinò
authors.affiliation: Department of Diagnostic Imaging, Santa Maria della Misericordia Hospital, University of Perugia, Perugia, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Maiettini
authors.affiliation: Department of Medical Oncology, Santa Maria della Misericordia Hospital, Perugia, Italy.
authors.forename: Rita
authors.initials: R
authors.lastname: Chiari
authors.affiliation: Department of Medical Oncology, Santa Maria della Misericordia Hospital, Perugia, Italy.
authors.forename: Giulio
authors.initials: G
authors.lastname: Metro
keywords: Biomarkers; Breast neoplasms; Human epidermal growth factor receptor 2; Linitis plastica; Neoplasm metastasis