title: Clinical-Radiologic-Pathologic Correlation of Smoking-Related Diffuse Parenchymal Lung Disease.
abstract: The direct toxicity of cigarette smoke and the body's subsequent response to this lung injury leads to a wide array of pathologic manifestations and disease states that lead to both reversible and irreversible injury to the large airways, small airways, alveolar walls, and alveolar spaces. These include emphysema, bronchitis, bronchiolitis, acute eosinophilic pneumonia, pulmonary Langerhans cell histiocytosis, respiratory bronchiolitis, desquamative interstitial pneumonia, and pulmonary fibrosis. Although these various forms of injury have different pathologic and imaging manifestations, they are all part of the spectrum of smoking-related diffuse parenchymal lung disease.
authors.affiliation: Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21231, USA. Electronic address: skligerman@umm.edu.
authors.forename: Seth
authors.initials: S
authors.lastname: Kligerman
authors.affiliation: Department of Defense, Defense Health Agency, Joint Pathology Center, 606 Stephen Sitter Avenue, Silver Spring, MD 20910-1290, USA.
authors.forename: Teri J
authors.initials: TJ
authors.lastname: Franks
authors.affiliation: Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21231, USA; Department of Thoracic Radiology, American Institute for Radiologic Pathology, 1010 Wayne Avenue, Suite 320, Silver Spring, MD 20910, USA.
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Galvin
mesh_terms: D003937:Diagnosis, Differential; D019317:Evidence-Based Medicine; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging* / Q000209:etiology*; D011650:Pulmonary Alveoli / Q000000981:diagnostic imaging* / Q000293:injuries*; D011856:Radiographic Image Enhancement / Q000379:methods; D013902:Radiography, Thoracic / Q000379:methods; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D013223:Statistics as Topic; D014057:Tomography, X-Ray Computed / Q000379:methods*
keywords: Desquamative interstitial pneumonia; Emphysema; Fibrosis; Langerhans cell; Respiratory bronchiolitis; Smoking