title: Annular Eruptive Pseudoangiomatosis and Adenovirus Infection: A Novel Clinical Variant of Paraviral Exanthems and a Novel Virus Association.
abstract: Eruptive pseudoangiomatosis is a distinct exanthem thought to be caused by viruses. The usual rash configu-ration is erythematous papules and macules. An association with echovirus infection has been reported. We present here one adult and one child with this exanthem, supported by clinical, histopathological, and immunohistochemical findings. Both patients presented with prodromal symptoms, widespread angioma-like macules in annular configuration, blanchable telangiectasia, followed by spontaneous remission in 6-8 weeks. Lesional histopathology of the adult patient revealed dilated dermal blood vessels and lymphohistiocytic infiltrates predominated by CD4+ lymphocytes with a 5:1 ratio of CD4:CD8 lymphocytes. No B cells or CD56+ natural killer cells were found. Serology of both patients revealed evidence of active infections by adenoviruses, and a range of other viruses were excluded. We believe that these 2 patients manifested annular eruptive pseudoangio-matosis, a novel variant of the rash with a probable adenovirus association that has not yet been reported.
authors.affiliation: Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong and the Prince of Wales Hospital, Shops 5 and 6, The Imperial Terrace, 356 Queen's Road West, G/F, Shatin, Hong Kong. antonio.chuh@yahoo.com.hk.
authors.forename: Antonio
authors.initials: A
authors.lastname: Chuh
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Panzer
authors.forename: Ann-Christine
authors.initials: AC
authors.lastname: Rosenthal
authors.forename: Ehrhardt
authors.initials: E
authors.lastname: Proksch
authors.forename: Werner
authors.initials: W
authors.lastname: Kempf
authors.forename: Vijay
authors.initials: V
authors.lastname: Zawar
authors.forename: Helmuth
authors.initials: H
authors.lastname: Fickenscher
authors.forename: Regina
authors.initials: R
authors.lastname: Fölster-Holst
mesh_terms: D000256:Adenoviridae / Q000276:immunology / Q000472:pathogenicity*; D000257:Adenoviridae Infections / Q000175:diagnosis / Q000276:immunology / Q000821:virology*; D000798:Angiomatosis / Q000175:diagnosis / Q000276:immunology / Q000821:virology*; D001706:Biopsy; D002675:Child, Preschool; D005076:Exanthema / Q000175:diagnosis / Q000276:immunology / Q000821:virology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D012075:Remission, Spontaneous; D012867:Skin / Q000276:immunology / Q000473:pathology / Q000821:virology*; D013997:Time Factors; D055815:Young Adult