title: Aggressive esthesioneuroblastoma with divergent differentiation: A taxonomic dilemma.
abstract: The authors describe an esthesioneuroblastoma (olfactory neuroblastoma) that occurred within the nasal cavity and brain in a 31-year-old man. Following excision, the tumor recurred in the left orbit and in mediastinal lymph nodes. Treatment included orbital excision and systemic chemotherapy. Histopathology showed a high-grade neuroepithelial tumor with positive immunohistochemical markers for neuroendocrine and epithelial components, an unusual combination raising issues concerning taxonomy.
authors.affiliation: a Department of Ophthalmology , New York University Langone Medical Center , New York , New York , USA.|b Department of Pathology , New York University Langone Medical Center , New York , New York , USA.
authors.forename: Norman C
authors.initials: NC
authors.lastname: Charles
authors.affiliation: a Department of Ophthalmology , New York University Langone Medical Center , New York , New York , USA.
authors.forename: Carisa K
authors.initials: CK
authors.lastname: Petris
authors.affiliation: a Department of Ophthalmology , New York University Langone Medical Center , New York , New York , USA.
authors.forename: Eleanore T
authors.initials: ET
authors.lastname: Kim
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000378:metabolism; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D018304:Esthesioneuroblastoma, Olfactory / Q000000981:diagnostic imaging / Q000556:secondary* / Q000628:therapy; D006801:Humans; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging; D008297:Male; D008482:Mediastinum; D009296:Nasal Cavity; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D009669:Nose Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D009918:Orbital Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary* / Q000628:therapy; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor
keywords: Esthesioneuroblastoma; olfactory neuroblastoma