title: Metal-free one-pot α-carboxylation of primary alcohols.
abstract: An efficient metal-free procedure for the formal α-carboxylation of primary alcohols has been developed. The method involves a one-pot oxidation/Passerini/hydrolysis sequence and provides access to α-hydroxy acids bearing a broad range of functional groups. A minor modification to the reaction conditions extends the range of accessible products to α-hydroxy esters.
authors.affiliation: Department of Chemistry and Pharmaceutical Sciences and Amsterdam Institute of Molecules, Medicines and Systems (AIMMS), Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands. r.v.a.orru@vu.nl e.ruijter@vu.nl.
authors.forename: Gydo
authors.initials: G
authors.lastname: van der Heijden
authors.affiliation: Department of Chemistry and Pharmaceutical Sciences and Amsterdam Institute of Molecules, Medicines and Systems (AIMMS), Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands. r.v.a.orru@vu.nl e.ruijter@vu.nl.
authors.forename: Jasper
authors.initials: J
authors.lastname: Kraakman
authors.affiliation: Department of Chemistry and Pharmaceutical Sciences and Amsterdam Institute of Molecules, Medicines and Systems (AIMMS), Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands. r.v.a.orru@vu.nl e.ruijter@vu.nl.
authors.forename: Jasper
authors.initials: J
authors.lastname: Biemolt
authors.affiliation: Department of Chemistry and Pharmaceutical Sciences and Amsterdam Institute of Molecules, Medicines and Systems (AIMMS), Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands. r.v.a.orru@vu.nl e.ruijter@vu.nl.
authors.forename: Eelco
authors.identifier: http://orcid.org/0000-0002-1105-3947
authors.initials: E
authors.lastname: Ruijter
authors.affiliation: Department of Chemistry and Pharmaceutical Sciences and Amsterdam Institute of Molecules, Medicines and Systems (AIMMS), Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands. r.v.a.orru@vu.nl e.ruijter@vu.nl.
authors.forename: Romano V A
authors.initials: RV
authors.lastname: Orru