title: A mesoporous organosilica nano-bowl with high DNA loading capacity - a potential gene delivery carrier.
abstract: Mesoporous organosilica nanoparticles with a novel bowl-like morphology were synthesized. These nano-bowls possess uniform particle sizes around 180 nm and open cavities around 140 nm, which lead to higher loading capability for plasmid DNA than traditional silica-based nanoparticles. In vitro DNA transfection using these nano-bowls is demonstrated.
authors.affiliation: School of Chemical Engineering, The University of Adelaide, SA 5005, Australia. s.qiao@adelaide.edu.au.
authors.forename: Lin
authors.initials: L
authors.lastname: Xiong
authors.affiliation: School of Chemical Engineering, The University of Adelaide, SA 5005, Australia. s.qiao@adelaide.edu.au.
authors.forename: Shi-Zhang
authors.initials: SZ
authors.lastname: Qiao
mesh_terms: D004247:DNA / Q000008:administration & dosage*; D018014:Gene Transfer Techniques; D005822:Genetic Vectors / Q000737:chemistry*; D053758:Nanoparticles; D016062:Porosity; D012822:Silicon Dioxide
chemical_list: D012822:Silicon Dioxide; D004247:DNA