title: The prevalence of non-tuberculous mycobacterial infections in mainland China: Systematic review and meta-analysis.
abstract: Despite increasing attention towards the non-tuberculous mycobacterial (NTM) diseases, the overall epidemiological information remains unavailable for China. A systematic review and meta-analysis was conducted using data of 105 qualified publications from Chinese mainland. The assay demonstrated that the prevalence of NTM infections among tuberculosis suspects was 6.3% (5.4%-7.4%) in mainland, while the Southeastern region had the highest NTM prevalence at 8.6% (7.1%-10.5%). In Northern China, slow growing mycobacteria (SGM) consistituted 63.7% of all the NTM isolates, while this rate in Southern China was 53.0%. More rapid growing mycobacteria (RGM) were present in southern China than the northern (χ2= 57.996, P < 0.001). According to the coastal provinces' data (from north to south), the NTM prevalence rate and the number of isolated NTM species increased apparently in accordance with geographic latitude. The information obtained in this assay will facilitate the NTM disease diagnosis and screening policy making in China.
authors.affiliation: National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Yu
authors.affiliation: Medical Library of Chinese People's Liberation Army, 59th, Middle Section West 4th Ring, Beijing, 100039, China.
authors.forename: Pengnian
authors.initials: P
authors.lastname: Liu
authors.affiliation: National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
authors.forename: Guan
authors.initials: G
authors.lastname: Liu
authors.affiliation: National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Zhao
authors.affiliation: National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
authors.forename: Yanjie
authors.initials: Y
authors.lastname: Hu
authors.affiliation: National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
authors.forename: Guomei
authors.initials: G
authors.lastname: Wei
authors.affiliation: National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Luo
authors.affiliation: National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China. Electronic address: huanghairong@tb123.org.
authors.forename: Hairong
authors.initials: H
authors.lastname: Huang
mesh_terms: D002681:China / Q000453:epidemiology; D006801:Humans; D009161:Mycobacterium / Q000302:isolation & purification; D009165:Mycobacterium Infections, Nontuberculous / Q000453:epidemiology* / Q000382:microbiology; D009170:Nontuberculous Mycobacteria / Q000145:classification / Q000302:isolation & purification*; D015995:Prevalence; D014376:Tuberculosis / Q000453:epidemiology
keywords: M. avium complex; M. chelonae–M. abscessus group; Non-tuberculous mycobacterium (NTM); Prevalence; Species identification