title: Functionalization of mixed ligand metal-organic frameworks as the transport vehicles for drugs.
abstract: We reported the design and synthesis of mixed ligands Cu-metal organic frameworks (MOFs), MOFs-2 and MOFs-3, and their application as the transport vehicles for the delivery of Ibuprofen (IBU) and doxorubicin hydrochloride (DOX). The unique MOFs with mixed ligands, 1,3,5-benzene tricarboxylate (BTC) and isophthalic acid (IPA), were easily prepared by hydro-thermal method, and their structures were well characterized by XRD, FTIR, and SEM imaging analysis. Single ligand MOFs with BTC or IPA only were also prepared and characterized as the control group. The biocompatibility of synthesized MOFs towards human cells, HEK 293A was evaluated by MTT assay. To demonstrate the practical applications of the prepared MOFs as the transport vehicles for drugs, the capability of loading and controlled release of IBU and DOX by MOFs-1, MOFs-2, MOFs-3, and MOFs-4 were then examined. In addition, the drug delivery efficiency of various MOFs with different ligands was investigated.
authors.affiliation: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Hubei University, Wuhan 430062, China.
authors.forename: Keke
authors.initials: K
authors.lastname: Sun
authors.affiliation: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Hubei University, Wuhan 430062, China; Ministry of Education Key Laboratory for the Synthesis and Application of Organic Function Molecules, Hubei University, Wuhan, China. Electronic address: waitingll@yahoo.com.
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.affiliation: College of Life Science, Hubei University, Wuhan 430062, China.
authors.forename: XiaoLan
authors.initials: X
authors.lastname: Yu
authors.affiliation: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Hubei University, Wuhan 430062, China.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.affiliation: School of Chemical Engineering, University of Science and Technology Liaoning, Anshan 114044, China.
authors.forename: Qingtao
authors.initials: Q
authors.lastname: Meng
authors.affiliation: College of Life Science, Hubei University, Wuhan 430062, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.affiliation: School of Chemical Engineering, University of Science and Technology Liaoning, Anshan 114044, China; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane 4072, Australia. Electronic address: r.zhang@uq.edu.au.
authors.forename: Run
authors.initials: R
authors.lastname: Zhang
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D003300:Copper / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers; D004339:Drug Compounding; D065546:Drug Liberation; D057809:HEK293 Cells; D006358:Hot Temperature; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007052:Ibuprofen / Q000737:chemistry / Q000494:pharmacology; D007700:Kinetics; D009942:Organometallic Compounds / Q000138:chemical synthesis*; D010795:Phthalic Acids / Q000737:chemistry; D014233:Tricarboxylic Acids / Q000737:chemistry; D014867:Water / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D009942:Organometallic Compounds; D010795:Phthalic Acids; D014233:Tricarboxylic Acids; D014867:Water; C059768:isophthalate; D003300:Copper; D004317:Doxorubicin; C069849:trimesic acid; D007052:Ibuprofen
keywords: Cu-MOFs; DOX; Drug-delivery; Hydro-thermal method; IBU; Mixed-ligands