title: Acute myocardial infarctionversusother cardiovascular events in community-acquired pneumonia.
abstract: The aim of the present study was to define the prevalence, characteristics, risk factors and impact on clinical outcomes of acute myocardial infarction (AMI)versusother cardiovascular events (CVEs) in patients with community-acquired pneumonia (CAP). This was an international, multicentre, observational, prospective study of CAP patients hospitalised in eight hospitals in Italy and Switzerland. Three groups were identified: those without CVEs, those with AMI and those with other CVEs. Among 905 patients, 21 (2.3%) patients experienced at least one AMI, while 107 (11.7%) patients experienced at least one other CVE. Patients with CAP and either AMI or other CVEs showed a higher severity of the disease than patients with CAP alone. Female sex, liver disease and the presence of severe sepsis were independent predictors for the occurrence of AMI, while female sex, age >65 years, neurological disease and the presence of pleural effusion predicted other CVEs. In-hospital mortality was significantly higher among those who experienced AMI in comparison to those experiencing other CVEs (43%versus21%, p=0.039). The presence of AMI showed an adjusted odds ratio for in-hospital mortality of 3.57 (p=0.012) and for other CVEs of 2.63 (p=0.002). These findings on AMIversusother CVEs as complications of CAP may be important when planning interventional studies on cardioprotective medications.
authors.affiliation: Health Science Department, University of Milan Bicocca, Respiratory Unit, AO San Gerardo, Monza, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Aliberti
authors.affiliation: Division of Infectious Diseases, Department of Medicine, University of Louisville, Louisville, KY, USA.
authors.forename: Julio
authors.initials: J
authors.lastname: Ramirez
authors.affiliation: Emergency Medicine Unit, IRCCS Fondazione Ospedale Maggiore Policlinico Cà Granda, Milan, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Cosentini
authors.affiliation: Pulmonary Unit, University of Milan, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Valenti
authors.affiliation: Emergency Department, IRCCS Humanitas Research Hospital, Rozzano, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Voza
authors.affiliation: Internal Medicine Department, Azienda Ospedaliero-Universitaria "S. Maria della Misericordia", Udine, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Rossi
authors.affiliation: Clinic of Respiratory Medicine and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland.
authors.forename: Daiana
authors.initials: D
authors.lastname: Stolz
authors.affiliation: Department of Biomedical and Clinical Sciences, University of Milan, Luigi Sacco Hospital, Milan, Italy.
authors.forename: Delfino
authors.initials: D
authors.lastname: Legnani
authors.affiliation: Health Science Department, University of Milan Bicocca, Respiratory Unit, AO San Gerardo, Monza, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Pesci
authors.affiliation: National Institute for Health Research Respiratory Biomedical Research Unit, Southampton, UK; Centre for Rare Lung Disease, University of Modena and Reggio Emilia, AO Policlinico, Modena, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Richeldi
authors.affiliation: Division of Infectious Diseases, Department of Medicine, University of Louisville, Louisville, KY, USA.
authors.forename: Paula
authors.initials: P
authors.lastname: Peyrani
authors.affiliation: UOC Malattie Cardiovascolari, Università degli Studi di Milano, IRCCS Fondazione Ospedale Maggiore Policlinico Cà Granda, Milan, Italy.
authors.forename: Fernando Maria
authors.initials: FM
authors.lastname: Massari
authors.affiliation: Department of Pathophysiology and Transplantation, Università degli Studi di Milano, IRCCS Fondazione Ospedale Maggiore Policlinico Cà Granda, Milan, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Blasi