title: Postoperative hormonal therapy prevents recovery of neurological damage after surgery in patients with breast cancer.
abstract: Cancer survivors are exposed to several risk factors for cognitive dysfunction, such as general anesthesia, surgical trauma, and adjuvant therapies. In our recent study we showed that thalamic volume reduction and attentional dysfunction occurred shortly after surgery. Here, we examined the 6-month prognosis of the 20 patients with breast cancer who underwent surgery. Seven patients did not receive any adjuvant therapy after the surgery and 13 patients received a hormonal therapy after the surgery. We assessed their attentional functions, and thalamic volumes shortly after and 6 months after surgery. We found a significant group x time interaction in the attentional functions (p = 0.033) and the right thalamus (p <  0.05, small volume correction), suggesting the thalamic volume reduction and attentional dysfunction recovered in patients without adjuvant therapy. Our findings provide a better understanding of the potential role of hormonal therapy in relation to the cognitive dysfunction of cancer survivors.
authors.affiliation: Department of Adult Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.|Division of Medical Neuroimage Analysis, Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.|Department of Functional Brain Imaging, Institute of Development, Aging and Cancer (IDAC), Tohoku University, Sendai, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sekiguchi
authors.affiliation: Department of Functional Brain Imaging, Institute of Development, Aging and Cancer (IDAC), Tohoku University, Sendai, Japan.|Division of Surgical Oncology, Graduate School of Medicine, Tohoku University, Sendai, Japan.
authors.forename: Chiho
authors.initials: C
authors.lastname: Sato
authors.affiliation: Department of Nuclear Medicine and Radiology, IDAC, Tohoku University, Sendai, Japan.
authors.forename: Izumi
authors.initials: I
authors.lastname: Matsudaira
authors.affiliation: Division of Clinical Research, Medical-Industry Translational Research Center, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kotozaki
authors.affiliation: Creative Interdisciplinary Research Division, Frontier Research Institute for Interdisciplinary Science, Tohoku University, Sendai, Japan.|Human and Social Response Research Division, International Research Institute of Disaster Science, Tohoku University, Sendai, Japan.|Department of Advanced Brain Science, Smart Ageing International Research Center, IDAC, Tohoku University, Sendai, Japan.
authors.forename: Rui
authors.initials: R
authors.lastname: Nouchi
authors.affiliation: Division of Developmental Cognitive Neuroscience, IDAC, Tohoku University, Sendai, Japan.
authors.forename: Hikaru
authors.initials: H
authors.lastname: Takeuchi
authors.affiliation: Department of Breast Oncology, Miyagi Cancer Center Hospital, Miyagi, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kawai
authors.affiliation: Division of Surgical Oncology, Graduate School of Medicine, Tohoku University, Sendai, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tada
authors.affiliation: Division of Surgical Oncology, Graduate School of Medicine, Tohoku University, Sendai, Japan.
authors.forename: Takanori
authors.initials: T
authors.lastname: Ishida
authors.affiliation: Division of Medical Neuroimage Analysis, Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.|Department of Nuclear Medicine and Radiology, IDAC, Tohoku University, Sendai, Japan.|Division of Developmental Cognitive Neuroscience, IDAC, Tohoku University, Sendai, Japan.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Taki
authors.affiliation: Division of Surgical Oncology, Graduate School of Medicine, Tohoku University, Sendai, Japan.
authors.forename: Noriaki
authors.initials: N
authors.lastname: Ohuchi
authors.affiliation: Department of Functional Brain Imaging, Institute of Development, Aging and Cancer (IDAC), Tohoku University, Sendai, Japan.|Department of Advanced Brain Science, Smart Ageing International Research Center, IDAC, Tohoku University, Sendai, Japan.|Division of Developmental Cognitive Neuroscience, IDAC, Tohoku University, Sendai, Japan.
authors.forename: Ryuta
authors.initials: R
authors.lastname: Kawashima
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000523:psychology / Q000601:surgery*; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D003131:Combined Modality Therapy; D005260:Female; D006727:Hormone Antagonists / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D011184:Postoperative Period; D011379:Prognosis; D011788:Quality of Life / Q000523:psychology; D020127:Recovery of Function; D013788:Thalamus / Q000000981:diagnostic imaging / Q000473:pathology*
chemical_list: D006727:Hormone Antagonists