title: Predictive ability of maximal tumor diameter on MRI for high-risk endometrial cancer.
abstract: To investigate the predictive ability of tumor size for deep myometrial invasion (≥50%) and metastatic lymphadenopathy, on maximal tumor diameter (MRI) of endometrial cancer.
  
  
  
  Our study population consisted of 105 patients (mean age: 59.8 years) with histologically confirmed endometrial cancer. All patients underwent preoperative pelvic MRI. Tumor maximal diameter (size) was calculated on multiple sequences, and the largest value was recorded. Logistic regression analysis was performed to investigate the association of maximal tumor diameter (MRI) with the depth of myometrial invasion and the presence of pelvic nodal metastases (histology); optimal tumor size cut-off for the prediction of deep myometrial involvement and nodal metastases was calculated using ROC analysis. Surgicopathological specimen examination was the standard of reference.
  
  
  
  Tumor size on MRI, independently predicted deep myometrial invasion. Optimal maximal tumor diameter cut-off for the prediction of deep myometrial invasion was 2 cm (SE 90%, SP 50.9%). When tumor size was used as a categorical variable in the multiple logistic regression model, tumor size >2 cm had 10.04 times greater odds of deep myometrial invasion (95% CI 3.34-30.17, p < 0.001). Optimal tumor size cut-off for prediction of nodal metastases was 4 cm (SE 60%, SP 76.9%). Multiple logistic regression analysis with nodal metastases as a dependent variable showed that tumor size >4 cm had 4.79 times greater odds for malignant dissemination to the lymph nodes (95% CI 1.00-23.09, p = 0.047).
  
  
  
  Maximal tumor diameter on preoperative MRI may be yet another prognosticator for deep myometrial invasion and metastatic lymphadenopathy in patients with endometrial carcinoma.
authors.affiliation: Department of Radiology, School of Medicine, Aretaieion Hospital, National and Kapodistrian University of Athens, 76 Vassilisis Sofias Ave., 11528, Athens, Greece. charisbourgioti@yahoo.com.
authors.forename: Charis
authors.initials: C
authors.lastname: Bourgioti
authors.affiliation: Department of Radiology, School of Medicine, Aretaieion Hospital, National and Kapodistrian University of Athens, 76 Vassilisis Sofias Ave., 11528, Athens, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Chatoupis
authors.affiliation: Department of Health, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, 25 Alexandroupoleos Str., 11527, Athens, Greece.
authors.forename: Chara
authors.initials: C
authors.lastname: Tzavara
authors.affiliation: Department of Radiology, School of Medicine, Aretaieion Hospital, National and Kapodistrian University of Athens, 76 Vassilisis Sofias Ave., 11528, Athens, Greece.
authors.forename: Aristeidis
authors.initials: A
authors.lastname: Antoniou
authors.affiliation: Department of Obstetrics and Gynecology, Gynecologic Oncology Unit, School of Medicine, Alexandra Hospital, National and Kapodistrian University of Athens, 80 Vassilisis Sofias Ave., 11528, Athens, Greece.
authors.forename: Alexandros
authors.initials: A
authors.lastname: Rodolakis
authors.affiliation: Department of Radiology, School of Medicine, Aretaieion Hospital, National and Kapodistrian University of Athens, 76 Vassilisis Sofias Ave., 11528, Athens, Greece.
authors.forename: Lia Angela
authors.initials: LA
authors.lastname: Moulopoulos
mesh_terms: D001706:Biopsy; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging; D016889:Endometrial Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000000981:diagnostic imaging* / Q000473:pathology*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D047368:Tumor Burden
chemical_list: D003287:Contrast Media
keywords: Diffusion-weighted imaging (DWI); Dynamic contrast-enhanced (DCE)-MRI; Endometrial cancer; Magnetic resonance imaging (MRI); Tumor size