title: Pretreatment with β-adrenergic receptor agonists facilitates induction of LTP and sharp wave ripple complexes in rodent hippocampus.
abstract: Norepinephrine, is involved in the enhancement of learning and memory formation by regulating synaptic mechanisms through its ability to activate pre- and post-synaptic adrenergic receptors. Here we show that β-agonists of norepinephrine facilitate the induction of both associational LTP and sharp wave ripples (SPW-Rs) in acute slices of rat hippocampus in area CA3. Surprisingly, this facilitating effect persists when slices are only pretreated with β-receptor agonists followed by wash out and application of the unspecific β-adrenoreceptor (βAR) antagonist propranolol. During application of βAR agonists repeated stimulation resulted in facilitated induction of SPW-Rs. Since SPW-Rs are thought to be involved in memory replay we studied the effects of βAR-agonists on spontaneous SPW-Rs in murine hippocampus and found that amplitude and incidence of SPW-Rs increased. These effects involve cyclic-AMP and the activation of protein kinase A and suggest a supportive role in memory consolidation. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Neuroscience Research Center, Charite Universitatsmedizin Berlin, Germany.|Department of Pharmacy, Abbottabad University of Science & Technology, Abbottabad, Pakistan.
authors.forename: Rizwan
authors.initials: R
authors.lastname: Ul Haq
authors.affiliation: Neuroscience Research Center, Charite Universitatsmedizin Berlin, Germany.
authors.forename: Marlene
authors.initials: M
authors.lastname: Anderson
authors.affiliation: Neuroscience Research Center, Charite Universitatsmedizin Berlin, Germany.
authors.forename: Agustin
authors.initials: A
authors.lastname: Liotta
authors.affiliation: Department of Pharmacy, Abbottabad University of Science & Technology, Abbottabad, Pakistan.
authors.forename: Maria
authors.initials: M
authors.lastname: Shafiq
authors.affiliation: Department of Pharmacy, Abbottabad University of Science & Technology, Abbottabad, Pakistan.
authors.forename: Muhammad Azhar
authors.initials: MA
authors.lastname: Sherkheli
authors.affiliation: Neuroscience Research Center, Charite Universitatsmedizin Berlin, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Heinemann
mesh_terms: D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D058256:Brain Waves / Q000187:drug effects / Q000502:physiology; D056547:CA1 Region, Hippocampal / Q000187:drug effects / Q000502:physiology; D056654:CA3 Region, Hippocampal / Q000187:drug effects* / Q000502:physiology; D007545:Isoproterenol / Q000494:pharmacology; D017774:Long-Term Potentiation / Q000187:drug effects* / Q000502:physiology; D008810:Mice, Inbred C57BL; D011433:Propranolol / Q000494:pharmacology; D017208:Rats, Wistar; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D046509:Tissue Culture Techniques
chemical_list: D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta; D011433:Propranolol; D007545:Isoproterenol
keywords: 8-Br-cAMP; LTP; dobutamine; propranolol; sharp wave ripples; β-agonists