title: Mild and Selective Mono-Iodination of Unprotected Peptides as Initial Step for the Synthesis of Bioimaging Probes.
abstract: Chemoselective functionalization of peptides and proteins to selectively introduce residues for detection, capture, or specific derivatization is of high interest to the synthetic community. Here we report a new method for the mild and effective mono-iodination of tyrosine residues in fully unprotected peptides. This method is highly chemoselective and compatible with a wide variety of functional groups. The introduced iodine can subsequently serve as a handle for further functionalization such as introduction of fluorescent dyes and thus be used for chemoselective labeling of isolated peptides.
authors.affiliation: Research & Development, Integrated Drug Discovery, Sanofi-Aventis Deutschland GmbH , 65926 Frankfurt am Main, Germany.|Department of Nuclear Medicine, Radboud UMC , Nijmegen 6525, The Netherlands.
authors.forename: Romain
authors.initials: R
authors.lastname: Bertrand
authors.affiliation: Research & Development, Integrated Drug Discovery, Sanofi-Aventis Deutschland GmbH , 65926 Frankfurt am Main, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Wagner
authors.affiliation: Research & Development, Integrated Drug Discovery, Sanofi-Aventis Deutschland GmbH , 65926 Frankfurt am Main, Germany.
authors.forename: Volker
authors.initials: V
authors.lastname: Derdau
authors.affiliation: Research & Development, Integrated Drug Discovery, Sanofi-Aventis Deutschland GmbH , 65926 Frankfurt am Main, Germany.|Leibniz Universität Hannover , Schneiderberg 1B, 30167 Hannover, Germany.|Institute of Medicinal Chemistry, Helmholtz Zentrum München, GmbH, German Research Center for Environmental Health , Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Plettenburg