title: Narrow band imaging versus autofluorescence imaging for head and neck squamous cell carcinoma detection: a prospective study.
abstract: OBJECTIVE
  This study aimed to compare the diagnostic effectiveness of narrow band imaging and autofluorescence imaging for malignant laryngopharyngeal tumours.
  
  
  METHODS
  Between May 2010 and October 2010, 50 consecutive patients with suspected laryngopharyngeal tumour underwent endoscopic laryngopharynx examination. The morphological characteristics of laryngopharyngeal lesions were analysed using high performance endoscopic systems equipped with narrow band imaging and autofluorescence imaging modes. The diagnostic effectiveness of white light image, narrow band imaging and autofluorescence imaging endoscopy for benign and malignant laryngopharyngeal lesions was evaluated.
  
  
  RESULTS
  Under narrow band imaging endoscopy, the superficial microvessels of squamous cell carcinomas appeared as dark brown spots or twisted cords. Under autofluorescence imaging endoscopy, malignant lesions appeared as bright purple. The sensitivity of malignant lesion diagnosis was not significantly different between narrow band imaging and autofluorescence imaging modes, but was better than for white light image endoscopy (χ2 = 12.676, p = 0.002). The diagnostic specificity was significantly better in narrow band imaging mode than in both autofluorescence imaging and white light imaging mode (χ2 = 8.333, p = 0.016).
  
  
  CONCLUSIONS
  Narrow band imaging endoscopy is the best option for the diagnosis and differential diagnosis of laryngopharyngeal tumours.
authors.affiliation: Department of Endoscopy,Cancer Hospital,Chinese Academy of Medical Sciences,Beijing,China.
authors.forename: X-G
authors.initials: XG
authors.lastname: Ni
authors.affiliation: Department of Endoscopy,Cancer Hospital,Chinese Academy of Medical Sciences,Beijing,China.
authors.forename: Q-Q
authors.initials: QQ
authors.lastname: Zhang
authors.affiliation: Department of Endoscopy,Cancer Hospital,Chinese Academy of Medical Sciences,Beijing,China.
authors.forename: G-Q
authors.initials: GQ
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging*; D005260:Female; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000000981:diagnostic imaging*; D007828:Laryngoscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D062048:Narrow Band Imaging / Q000379:methods*; D061848:Optical Imaging / Q000379:methods*; D010610:Pharyngeal Neoplasms / Q000000981:diagnostic imaging*; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D000077195:Squamous Cell Carcinoma of Head and Neck
keywords: Early Diagnosis; Head and Neck; Laryngoscopy; Narrow Band Imaging; Optical Imaging; Squamous Cell Carcinoma