title: Synthesis of Ag doped calcium phosphate particles and their antibacterial effect as additives in dental glass ionomer cements.
abstract: Developing dental restorations with enhanced antibacterial properties has been a constant quest for materials scientists. The aim of this study was to synthesize silver doped calcium phosphate particles and use them to improve antibacterial properties of conventional glass ionomer cement. The Ag doped monetite (Ag-DCPA) and hydroxyapatite (Ag-HA) were synthesized by precipitation method and characterized using X-ray diffraction, scanning electron microscope and X-ray fluorescence spectroscopy. The antibacterial properties of the cements aged for 1 day and 7 days were evaluated by direct contact measurement using staphylococcus epidermis Xen 43. Ion concentrations (F-and Ag+) and pH were measured to correlate to the results of the antibacterial study. The compressive strength of the cements was evaluated with a crosshead speed of 1 mm/min. The glass ionomer cements containing silver doped hydroxyapatite or monetite showed improved antibacterial properties. Addition of silver doped hydroxyapatite or monetite did not change the pH and ion release of F-. Concentration of Ag+was under the detection limit (0.001 mg/L) for all samples. Silver doped hydroxyapatite or monetite had no effect on the compressive strength of glass ionomer cement.
authors.affiliation: Applied Materials Science, Department of Engineering Science, Uppsala University, Uppsala, Sweden.
authors.forename: Song
authors.initials: S
authors.lastname: Chen
authors.affiliation: Applied Materials Science, Department of Engineering Science, Uppsala University, Uppsala, Sweden.
authors.forename: Satwik
authors.initials: S
authors.lastname: Gururaj
authors.affiliation: Applied Materials Science, Department of Engineering Science, Uppsala University, Uppsala, Sweden. wei.xia@angstrom.uu.se.
authors.forename: Wei
authors.initials: W
authors.lastname: Xia
authors.affiliation: Applied Materials Science, Department of Engineering Science, Uppsala University, Uppsala, Sweden.
authors.forename: Håkan
authors.initials: H
authors.lastname: Engqvist
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D019245:Compressive Strength; D003738:Dental Cements / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry; D005459:Fluorides / Q000737:chemistry; D005899:Glass Ionomer Cements; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007477:Ions; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D012834:Silver / Q000737:chemistry*; D013052:Spectrometry, X-Ray Emission; D013212:Staphylococcus epidermidis; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D002130:Calcium Phosphates; D003738:Dental Cements; D005899:Glass Ionomer Cements; D007477:Ions; D012834:Silver; D017886:Durapatite; C020243:calcium phosphate; D005459:Fluorides