title: Secondary malignancies after partial versus whole breast irradiation: a systematic review and meta-analysis.
abstract: Secondary malignancies are a common complication for patients receiving radiotherapy. Here, we compared rates of secondary malignancies after partial breast irradiation (PBI) and whole breast irradiation (WBI). The MEDLINE, EMBASE, and the Cochrane Library databases were systematically searched to identify relevant randomized clinical trials comparing PBI with WBI in breast cancer patients treated with breast-conserving therapy. Four studies including 2,185 patients were selected. Compared to WBI, the pooled odds ratios (OR) for contralateral breast cancer were 0.86 (95% confidence interval (CI) 0.31-2.42; p = 0.78) after 5 years and 1.15 (95% CI 0.43-3.09; p = 0.78) after 10 years for PBI. The pooled ORs for secondary non-breast cancer were 0.91 (95% CI 0.49-1.67; p = 0.77) after 5 years and 1.20 (95% CI 0.39-3.66; p = 0.75) after 10 years for PBI compared to WBI. These results demonstrate that the risk of secondary malignancies is similar for PBI and WBI after breast-conserving radiotherapy.
authors.affiliation: Department of Radiation Oncology, Cancer Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
authors.forename: Xin-Bin
authors.initials: XB
authors.lastname: Pan
authors.affiliation: Department of Radiation Oncology, Cancer Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
authors.forename: Shi-Ting
authors.initials: ST
authors.lastname: Huang
authors.affiliation: Department of Radiation Oncology, Cancer Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
authors.forename: Yan-Ming
authors.initials: YM
authors.lastname: Jiang
authors.affiliation: Department of Radiation Oncology, Cancer Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
authors.forename: Jia-Lin
authors.initials: JL
authors.lastname: Ma
authors.affiliation: Department of Radiation Oncology, Cancer Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Zhu
mesh_terms: D001940:Breast / Q000528:radiation effects*; D001943:Breast Neoplasms / Q000532:radiotherapy*; D059248:Chemoradiotherapy; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D016609:Neoplasms, Second Primary / Q000209:etiology*
keywords: breast cancer; breast-conserving therapy; partial breast irradiation; secondary malignancies; whole breast irradiation