title: Cocaine-Induced Microvascular Dysfunction and its Reversal by Administration of Intracoronary Calcium-Channel Blocker.
abstract: A 47-year-old male smoker with recent cocaine use presented with 6 hours of chest pain unrelieved by sublingual and intravenous nitroglycerin. To our knowledge, this is the first reported case demonstrating the efficacy of an intracoronary calcium-channel blocker to ameliorate cocaine-induced microvascular spasm.
authors.forename: Bhalaghuru
authors.initials: B
authors.lastname: Chokkalingam Mani
authors.forename: David L
authors.initials: DL
authors.lastname: Fischman
authors.affiliation: Cardiac Catheterization Laboratory, Thomas Jefferson University Hospital. Gibbon Bldg., Ste 6210, 111 S. 11th Street, Philadelphia, PA 19107 USA. michael.savage@jefferson.edu.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Savage
mesh_terms: D002637:Chest Pain / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D019970:Cocaine-Related Disorders / Q000150:complications*; D017023:Coronary Angiography / Q000379:methods; D003329:Coronary Vasospasm / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology; D004562:Electrocardiography / Q000379:methods; D006801:Humans; D007269:Injections, Intra-Arterial; D008297:Male; D008875:Middle Aged; D009529:Nicardipine / Q000008:administration & dosage*; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage
chemical_list: D014665:Vasodilator Agents; D009529:Nicardipine