title: miRNAs in acute myeloid leukemia.
abstract: MicroRNAs (miRNAs) are small, non-coding RNAs found throughout the eukaryotes that control the expression of a number of genes involved in commitment and differentiation of hematopoietic stem cells and tumorigenesis. Widespread dysregulation of miRNAs have been found in hematological malignancies, including human acute myeloid leukemia (AML). A comprehensive understanding of the role of miRNAs within the complex regulatory networks that are disrupted in malignant AML cells is a prerequisite for the development of therapeutic strategies employing miRNA modulators. Herein, we review the roles of emerging miRNAs and the miRNAs regulatory networks in AML pathogenesis, prognosis, and miRNA-directed therapies.
authors.affiliation: Key Laboratory for Rare & Uncommon Dseases of Shandong Province, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong, P.R. China.|School of Medicine and Life Sciences, Jinan University, Jinan, Shandong, P.R. China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Liao
authors.affiliation: Department of Hematology, Shengli Oilfield Central Hospital, Dongying, Shandong, P.R. China.
authors.forename: Bingping
authors.initials: B
authors.lastname: Wang
authors.affiliation: Key Laboratory for Rare & Uncommon Dseases of Shandong Province, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong, P.R. China.|Shandong University School of Medicine, Jinan, Shandong, P.R. China.
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.affiliation: Key Laboratory for Rare & Uncommon Dseases of Shandong Province, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong, P.R. China.
authors.forename: Guosheng
authors.initials: G
authors.lastname: Jiang
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D015973:Gene Expression Regulation, Leukemic; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000378:metabolism / Q000401:mortality / Q000628:therapy; D035683:MicroRNAs / Q000235:genetics*; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000378:metabolism; D011379:Prognosis; D034622:RNA Interference; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D035683:MicroRNAs; D012333:RNA, Messenger
keywords: acute myeloid leukemia; miRNA-directed therapy; miRNAs regulatory signaling pathways; pathogenesis; prognosis