title: Diagnostic Performance of Intravascular Ultrasound-Derived Minimal Lumen Area to Predict Functionally Significant Non-Left Main Coronary Artery Disease: a Meta-Analysis.
abstract: OBJECTIVE
  Intravascular ultrasound (IVUS)-guided percutaneous coronary intervention frequently results in unnecessary stenting due to the low positive predictive value of IVUS-derived minimal lumen area (MLA) for identification of functionally significant coronary stenosis. We appraised the diagnostic accuracy of IVUS-derived MLA compared with the fractional flow reserve (FFR) to assess intermediate coronary stenosis.
  
  
  METHODS
  We searched MEDLINE and Cochrane databases for studies using IVUS and FFR methods to establish the best MLA cut-off values to predict significant non-left main coronary artery stenosis. Summary estimates were obtained using a random-effects model.
  
  
  RESULTS
  The 17 studies used in our analysis enrolled 3920 patients with 4267 lesions. The weighted overall mean MLA cut-off value was 2.58 mm2. The pooled MLA sensitivity that predicted functionally significant coronary stenosis was 0.75 (confidence interval [CI]: 0.72 to 0.77) and the specificity was 0.66 (CI: 0.64 to 0.68). The positive likelihood ratio (LR) was 2.33 (CI: 2.06 to 2.63) and LR (-) was 0.33 (CI: 0.26 to 0.42). The pooled diagnostic odds ratio (DOR) was 7.53 (CI: 5.26 to 10.76) and the area under the summary receiver operating characteristic curve for all the trials was 0.782 with a Q point of 0.720. Meta-regression analysis demonstrated that an FFR cut-off point of 0.75 was associated with a four times higher diagnostic accuracy compared to that of 0.80 (relative DOR: 3.92; 95% CI: 1.25 to 12.34).
  
  
  CONCLUSIONS
  IVUS-derived MLA has limited diagnostic accuracy and needs careful interpretation to correlate with functionally significant non-left main coronary artery stenosis.
authors.affiliation: Division of Cardiology, Busan Paik Hospital, University of Inje College of Medicine, Busan, Korea.
authors.forename: Jae-Sik
authors.initials: JS
authors.lastname: Jang
authors.affiliation: Division of Cardiology, Busan Paik Hospital, University of Inje College of Medicine, Busan, Korea.
authors.forename: Ho-Cheol
authors.initials: HC
authors.lastname: Shin
authors.affiliation: Department of Neurology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
authors.forename: Jong Seok
authors.initials: JS
authors.lastname: Bae
authors.affiliation: Division of Cardiology, Busan Paik Hospital, University of Inje College of Medicine, Busan, Korea.
authors.forename: Han-Young
authors.initials: HY
authors.lastname: Jin
authors.affiliation: Division of Cardiology, Busan Paik Hospital, University of Inje College of Medicine, Busan, Korea.
authors.forename: Jeong-Sook
authors.initials: JS
authors.lastname: Seo
authors.affiliation: Division of Cardiology, Busan Paik Hospital, University of Inje College of Medicine, Busan, Korea.
authors.forename: Tae-Hyun
authors.initials: TH
authors.lastname: Yang
authors.affiliation: Division of Cardiology, Busan Paik Hospital, University of Inje College of Medicine, Busan, Korea.
authors.forename: Dae-Kyeong
authors.initials: DK
authors.lastname: Kim
authors.affiliation: Division of Cardiology, Kosin University Medical Center, Busan, Korea.
authors.forename: Kyoung-Im
authors.initials: KI
authors.lastname: Cho
authors.affiliation: Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
authors.forename: Bo-Hyun
authors.initials: BH
authors.lastname: Kim
authors.affiliation: Division of Cardiology, Pusan National University Yangsan Hospital, Yangsan, Korea.
authors.forename: Yong Hyun
authors.initials: YH
authors.lastname: Park
authors.affiliation: Department of Cardiovascular Surgery, Busan National University Yangsan Hospital, Yangsan, Korea.
authors.forename: Hyung-Gon
authors.initials: HG
authors.lastname: Je
authors.affiliation: Division of Cardiology, Busan Paik Hospital, University of Inje College of Medicine, Busan, Korea.
authors.forename: Dong-Soo
authors.initials: DS
authors.lastname: Kim
keywords: Fractional flow reserve; Intravascular ultrasonography; Percutaneous coronary intervention