title: The ICCAM platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part B: fMRI description.
abstract: We aimed to set up a robust multi-centre clinical fMRI and neuropsychological platform to investigate the neuropharmacology of brain processes relevant to addiction - reward, impulsivity and emotional reactivity. Here we provide an overview of the fMRI battery, carried out across three centres, characterizing neuronal response to the tasks, along with exploring inter-centre differences in healthy participants.
  
  
  
  Three fMRI tasks were used: monetary incentive delay to probe reward sensitivity, go/no-go to probe impulsivity and an evocative images task to probe emotional reactivity. A coordinate-based activation likelihood estimation (ALE) meta-analysis was carried out for the reward and impulsivity tasks to help establish region of interest (ROI) placement. A group of healthy participants was recruited from across three centres (total n=43) to investigate inter-centre differences. Principle observations: The pattern of response observed for each of the three tasks was consistent with previous studies using similar paradigms. At the whole brain level, significant differences were not observed between centres for any task.
  
  
  
  In developing this platform we successfully integrated neuroimaging data from three centres, adapted validated tasks and applied whole brain and ROI approaches to explore and demonstrate their consistency across centres.
authors.affiliation: 1 Centre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College London, London, UK.
authors.forename: John
authors.initials: J
authors.lastname: McGonigle
authors.affiliation: 2 Neuroscience and Psychiatry Unit, Institute of Brain, Behaviour and Mental Health, The University of Manchester, Manchester, UK.
authors.forename: Anna
authors.initials: A
authors.lastname: Murphy
authors.affiliation: 1 Centre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College London, London, UK.
authors.forename: Louise M
authors.initials: LM
authors.lastname: Paterson
authors.affiliation: 1 Centre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College London, London, UK.
authors.forename: Laurence J
authors.initials: LJ
authors.lastname: Reed
authors.affiliation: 1 Centre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College London, London, UK.|3 Department of Psychiatry, University of Cambridge, Cambridge, UK.
authors.forename: Liam
authors.initials: L
authors.lastname: Nestor
authors.affiliation: 1 Centre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College London, London, UK.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Nash
authors.affiliation: 2 Neuroscience and Psychiatry Unit, Institute of Brain, Behaviour and Mental Health, The University of Manchester, Manchester, UK.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Elliott
authors.affiliation: 3 Department of Psychiatry, University of Cambridge, Cambridge, UK.|4 Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
authors.forename: Karen D
authors.initials: KD
authors.lastname: Ersche
authors.affiliation: 1 Centre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College London, London, UK.
authors.forename: Remy Sa
authors.initials: RS
authors.lastname: Flechais
authors.affiliation: 5 Imanova Limited, London, UK.
authors.forename: Rexford
authors.initials: R
authors.lastname: Newbould
authors.affiliation: 1 Centre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College London, London, UK.
authors.forename: Csaba
authors.initials: C
authors.lastname: Orban
authors.affiliation: 4 Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
authors.forename: Dana G
authors.initials: DG
authors.lastname: Smith
authors.affiliation: 2 Neuroscience and Psychiatry Unit, Institute of Brain, Behaviour and Mental Health, The University of Manchester, Manchester, UK.
authors.forename: Eleanor M
authors.initials: EM
authors.lastname: Taylor
authors.affiliation: 6 Centre for Neuroinflammation and Neurodegeneration, Division of Brain Sciences, Imperial College London, London, UK.
authors.forename: Adam D
authors.initials: AD
authors.lastname: Waldman
authors.affiliation: 4 Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.|7 Department of Psychology, University of Cambridge, Cambridge, UK.
authors.forename: Trevor W
authors.initials: TW
authors.lastname: Robbins
authors.affiliation: 2 Neuroscience and Psychiatry Unit, Institute of Brain, Behaviour and Mental Health, The University of Manchester, Manchester, UK.
authors.forename: Jf William
authors.initials: JW
authors.lastname: Deakin
authors.affiliation: 1 Centre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College London, London, UK.
authors.forename: David J
authors.initials: DJ
authors.lastname: Nutt
authors.affiliation: 1 Centre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College London, London, UK.
authors.forename: Anne R
authors.initials: AR
authors.lastname: Lingford-Hughes
authors.affiliation: 3 Department of Psychiatry, University of Cambridge, Cambridge, UK.|4 Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.|8 Cambridgeshire and Peterborough NHS Foundation Trust, Fulbourn, UK.
authors.forename: John
authors.initials: J
authors.lastname: Suckling
mesh_terms: D000328:Adult; D016739:Behavior, Addictive / Q000517:prevention & control*; D035843:Biomedical Research / Q000379:methods; D001921:Brain / Q000187:drug effects; D016022:Case-Control Studies; D004644:Emotions / Q000187:drug effects; D005260:Female; D006801:Humans; D007175:Impulsive Behavior / Q000187:drug effects; D016013:Likelihood Functions; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009042:Motivation / Q000187:drug effects; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D012201:Reward; D055502:Secondary Prevention / Q000379:methods; D055815:Young Adult
chemical_list: D004364:Pharmaceutical Preparations
keywords: Brain; human; magnetic resonance imaging; substance-related disorders