title: Association of serum irisin concentrations with the presence and severity of obstructive sleep apnea syndrome.
abstract: OBJECTIVE
  Obesity is involved in the pathogenesis of obstructive sleep apnea syndrome (OSAS). Irisin, a recently discovered myokine, protects the mice from obesity. This study aims to determine the association of serum irisin concentrations with the presence and severity of OSAS.
  
  
  METHODS
  This cross-sectional investigation was performed in 165 male OSAS patients and 98 healthy male subjects. Serum irisin concentrations were assessed using an enzyme-linked immunosorbent assay kit.
  
  
  RESULTS
  The serum irisin concentrations of OSAS patients significantly decreased compared with the healthy controls (P<.001). Multivariable logistic regression analysis indicated that serum irisin concentrations were an independent determinant of OSAS (OR .971, 95% CI .960 to .981; P<.001). Serum irisin concentrations were significantly reduced among patients with severe OSAS compared with patients with mild and moderate OSAS (P<.001 and P=.010, respectively). Spearman correlation analysis revealed that serum irisin concentrations were inversely correlated with OSAS severity (r=-.327, P<.001).
  
  
  CONCLUSIONS
  Decreased serum irisin concentrations are associated with the presence and severity of OSAS.
authors.affiliation: Department of Respiratory and Critical Care Medicine, Southern Hospital, Southern Medical University, Guangzhou, China.|Department of Respiration, Inner Mongolia People's Hospital, Hohhot, China.
authors.forename: Yanli
authors.initials: Y
authors.lastname: Li
authors.affiliation: Inner Mongolia Medical University, Hohhot, China.
authors.forename: Xueqin
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Respiration, Inner Mongolia People's Hospital, Hohhot, China.
authors.forename: Dejun
authors.initials: D
authors.lastname: Sun
authors.affiliation: Department of Respiratory and Critical Care Medicine, Southern Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Shaoxi
authors.initials: S
authors.lastname: Cai
mesh_terms: D003430:Cross-Sectional Studies; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000453:epidemiology*; D018709:Statistics, Nonparametric
chemical_list: D005353:Fibronectins
keywords: inflammation; irisin; obesity; obstructive sleep apnea syndrome