title: Pharmacokinetic and Pharmacodynamic Interaction of Andrographolide and Standardized Extract of Andrographis paniculata (Nees) with Nabumetone in Wistar Rats.
abstract: The aim of the study was to investigate the herb-drug interaction of Andrographis paniculata Nees (Acanthaceae) and Andrographolide (AN) with nabumetone (NAB) in wistar rats. Pharmacokinetic and pharmacodynamic interactions were studied after co-administration of APE and AN with NAB in Wistar rats. In pharmacokinetic studies, significant decrease in Cmax, AUC0-tand AUC0-∞of 6-MNA after co-administration with pure AN and APE has been observed. Tmaxof 6-MNA has been increased to 2 h from 1.5 h in AN + NAB treated group. Changes in mean residential time, clearance and volume of distribution of 6-MNA in APE + NAB treated group and AN + NAB treated group indicated interference of other components of APE other than AN. In pharmacodynamic study, significant decrease in antiarthritic activity of NAB on concomitant administration with APE and AN has been observed. The study concludes that NAB exhibits pharmacokinetic and pharmacodynamic interactions with APE and AN in rats thus alarms the concomitant use of herbal preparations containing APE and AN with NAB. Further study is needed to understand the mechanism and predict the herb-drug interaction in humans. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth, Deemed University (BVDU), Pune, 411 038, India.
authors.forename: Aishwarya
authors.initials: A
authors.lastname: Balap
authors.affiliation: Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth, Deemed University (BVDU), Pune, 411 038, India.
authors.forename: Sathiyanarayanan
authors.initials: S
authors.lastname: Lohidasan
authors.affiliation: Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University (BVDU), Pune, 411 038, India.
authors.forename: Arulmozhi
authors.initials: A
authors.lastname: Sinnathambi
authors.affiliation: Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth, Deemed University (BVDU), Pune, 411 038, India.
authors.forename: Kakasaheb
authors.initials: K
authors.lastname: Mahadik
mesh_terms: D035685:Andrographis / Q000737:chemistry*; D000818:Animals; D002074:Butanones / Q000737:chemistry* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000493:pharmacokinetics*; D005260:Female; D041743:Herb-Drug Interactions; D000077430:Nabumetone; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002074:Butanones; D004224:Diterpenes; D010936:Plant Extracts; C030419:andrographolide; D000077430:Nabumetone
keywords: Andrographis paniculata Nees extract; andrographolide; herb-drug interaction; nabumetone; pharmacodynamics; pharmacokinetics