title: Mesenchymal stem cells moderate immune response of type 1 diabetes.
abstract: Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by lack of insulin and irreversible destruction of islet β cells. In order to alleviate the symptoms, lifelong exogenous insulin administration has been the primary treatment of T1DM. In recent years, as a novel promising therapy, the transplantation of mesenchymal stem cells (MSCs) with or without pancreatic islets has achieved great therapeutic effects in animal models due to their multipotency along with their secretion of cytokines, angiogenic factors and immunomodulatory substances. There is plenty of evidence showing that MSCs can delay T1DM onset, reverse hyperglycemia after onset and increase insulin production. To date, the immunoregulation and immunosuppression of MSCs have been widely proved but the exact mechanisms are still not clear enough. Therefore, in this review, we mainly discuss the immunologic mechanism of MSCs in moderating the immune response of T1DM.
authors.affiliation: The Key Laboratory of Pathobiology, Ministry of Education, Norman Bethune Medical College, Jilin University, Changchun, 130021, China.
authors.forename: Junbi
authors.initials: J
authors.lastname: Xv
authors.affiliation: Department of Neurology, The First Hospital of Jilin University, Clinical Medical School, Jilin University, Changchun, 130021, China.
authors.forename: Qianwen
authors.initials: Q
authors.lastname: Ming
authors.affiliation: Department of Cardiology, The Third Hospital of Jilin University, Clinical Medical School, Jilin University, Changchun, 130021, China.
authors.forename: Xiaotong
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, The Third Hospital of Jilin University, Clinical Medical School, Jilin University, Changchun, 130021, China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology, The Third Hospital of Jilin University, Clinical Medical School, Jilin University, Changchun, 130021, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Clinical Medical School, Jilin University, Changchun, 130021, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Wang
authors.affiliation: The Key Laboratory of Pathobiology, Ministry of Education, Norman Bethune Medical College, Jilin University, Changchun, 130021, China.
authors.forename: Yulin
authors.initials: Y
authors.lastname: Li
authors.affiliation: The Key Laboratory of Pathobiology, Ministry of Education, Norman Bethune Medical College, Jilin University, Changchun, 130021, China. lilisha@jlu.edu.cn.
authors.forename: Lisha
authors.initials: L
authors.lastname: Li
mesh_terms: D000818:Animals; D016764:Cell Polarity; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D006801:Humans; D056747:Immunomodulation; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D008954:Models, Biological; D013601:T-Lymphocytes / Q000166:cytology
keywords: Immunomodulation; Mechanism; Mesenchymal stem cells; T cells; Type 1 diabetes mellitus