title: Update on De-intensification and Intensification Studies in HPV.
abstract: In this chapter, we discuss de-esclation of treatment for patients with HPV-positive disease. We discuss the rationale for de-escalation (why de-escalate?), patient selection criteria (who to de-esclate?) and what the treatment options for de-esclation are and the studies that are currently being run in those areas (how to de-escalate?). We stress the importance of clinicians NOT changing the management of oropharyngeal cancer patients outside clinical trials, and encourage them to recruit to the ongoing studies.
authors.affiliation: Chair of Head and Neck Surgery, School of Cancer Sciences, University of Birmingham, Birmingham, England, UK. h.mehanna@bham.ac.uk.|Institute of Head and Neck Studies and Education, University of Birmingham, Birmingham, England, UK. h.mehanna@bham.ac.uk.
authors.forename: Hisham
authors.initials: H
authors.lastname: Mehanna
mesh_terms: D006801:Humans; D009959:Oropharyngeal Neoplasms / Q000628:therapy / Q000821:virology*; D027383:Papillomaviridae / Q000472:pathogenicity*; D030361:Papillomavirus Infections / Q000628:therapy / Q000821:virology*
keywords: De-escalation of HPV; Epidemiology of HPV; Head and neck cancer; Molecular biology of HPV; Testing of HPV; Treatment of HPV