title: A norovirus intervariant GII.4 recombinant in Victoria, Australia, June 2016: the next epidemic variant?
abstract: A norovirus recombinant GII.P4_NewOrleans_2009/GII.4_Sydney_2012 was first detected in Victoria, Australia, in August 2015 at low frequency, and then re-emerged in June 2016, having undergone genetic changes. Analysis of 14 years' surveillance data from Victoria suggests a typical delay of two to seven months between first detection of a new variant and occurrence of a subsequent epidemic linked to that variant. We consider that the current recombinant strain has the potential to become a pandemic variant.
authors.affiliation: Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital, The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
authors.forename: Leesa
authors.initials: L
authors.lastname: Bruggink
authors.forename: Michael
authors.initials: M
authors.lastname: Catton
authors.forename: John
authors.initials: J
authors.lastname: Marshall
mesh_terms: D000595:Amino Acid Sequence; D001315:Australia / Q000453:epidemiology; D017250:Caliciviridae Infections / Q000453:epidemiology / Q000821:virology*; D004196:Disease Outbreaks; D005243:Feces / Q000821:virology; D005759:Gastroenteritis / Q000453:epidemiology / Q000821:virology*; D005838:Genotype; D006801:Humans; D008969:Molecular Sequence Data; D029322:Norovirus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D058873:Pandemics / Q000517:prevention & control; D010802:Phylogeny; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics; D048348:Reverse Transcription; D014739:Victoria / Q000453:epidemiology
chemical_list: D012367:RNA, Viral
keywords: emergence; epidemic; norovirus; pandemic; recombination; variant