title: Effect of intraarticular inoculation of mesenchymal stem cells in dogs with hip osteoarthritis by means of objective force platform gait analysis: concordance with numeric subjective scoring scales.
abstract: BACKGROUND
  Subjective pain assessment scales have been widely used for assessing lameness in response to pain, but the accuracy of these scales has been questioned. To assess scale accuracy, 10 lame, presa Canario dogs with osteoarthritis (OA) associated with bilateral hip dysplasia were first treated with mesenchymal stem cells. Then, potential lameness improvement was analyzed using two pain scales (Bioarth and visual analog scale). These data were compared with similar data collected using a force platform with the same animals during a period of 6 months after treatment.
  
  
  RESULTS
  The F test for intraclass correlation showed that concordance in pain/lameness scores between the 2 measuring methodologies was not significant (P value ≥ 0.9213; 95 % confidence interval, -0.56, 0.11). Although subjective pain assessment showed improvement after 6 months, force platform data demonstrated those same animals had returned to the initial lameness state.
  
  
  CONCLUSIONS
  Use of pain assessment scales to measure lameness associated with OA did not have great accuracy and concordance when compared with quantitative force platform gait analysis.
authors.affiliation: Department of Animal Pathology, Universidad de Las Palmas de Gran Canaria, Trasmontaña S/N, 35416, Arucas, Las Palmas, Spain. jose.vilar@ulpgc.es.
authors.forename: Jose M
authors.identifier: http://orcid.org/0000-0002-2060-2274
authors.initials: JM
authors.lastname: Vilar
authors.affiliation: Department of Animal Medicine and Surgery, Cátedra Garcia Cugat, CEU Cardenal Herrera University, C/Tirant lo Blanc, 7, 46115, Alfara del Patriarca, Valencia, Spain.
authors.forename: Belen
authors.initials: B
authors.lastname: Cuervo
authors.affiliation: Department of Animal Medicine and Surgery, Cátedra Garcia Cugat, CEU Cardenal Herrera University, C/Tirant lo Blanc, 7, 46115, Alfara del Patriarca, Valencia, Spain.
authors.forename: Monica
authors.initials: M
authors.lastname: Rubio
authors.affiliation: Department of Animal Medicine and Surgery, Cátedra Garcia Cugat, CEU Cardenal Herrera University, C/Tirant lo Blanc, 7, 46115, Alfara del Patriarca, Valencia, Spain.
authors.forename: Joaquín
authors.initials: J
authors.lastname: Sopena
authors.affiliation: Department of Animal Medicine and Surgery, University of Cordoba, 14071, Cordoba, Spain.
authors.forename: Juan M
authors.initials: JM
authors.lastname: Domínguez
authors.affiliation: Department of Animal Pathology, Universidad de Las Palmas de Gran Canaria, Trasmontaña S/N, 35416, Arucas, Las Palmas, Spain.
authors.forename: Angelo
authors.initials: A
authors.lastname: Santana
authors.affiliation: Department of Animal Medicine and Surgery, Cátedra Garcia Cugat, CEU Cardenal Herrera University, C/Tirant lo Blanc, 7, 46115, Alfara del Patriarca, Valencia, Spain.
authors.forename: Jose M
authors.initials: JM
authors.lastname: Carrillo
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D005260:Female; D005684:Gait; D006621:Hip Joint / Q000473:pathology*; D007270:Injections, Intra-Articular; D007794:Lameness, Animal; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods / Q000662:veterinary*; D010003:Osteoarthritis / Q000628:therapy / Q000662:veterinary*; D016474:Weight-Bearing / Q000502:physiology
keywords: Dog; Force platform; Mesenchymal stem cells; Osteoarthritis; Pain assessment; Visual analog scale