title: Salicylic acid receptors activate jasmonic acid signalling through a non-canonical pathway to promote effector-triggered immunity.
abstract: It is an apparent conundrum how plants evolved effector-triggered immunity (ETI), involving programmed cell death (PCD), as a major defence mechanism against biotrophic pathogens, because ETI-associated PCD could leave them vulnerable to necrotrophic pathogens that thrive on dead host cells. Interestingly, during ETI, the normally antagonistic defence hormones, salicylic acid (SA) and jasmonic acid (JA) associated with defence against biotrophs and necrotrophs respectively, both accumulate to high levels. In this study, we made the surprising finding that JA is a positive regulator of RPS2-mediated ETI. Early induction of JA-responsive genes and de novo JA synthesis following SA accumulation is activated through the SA receptors NPR3 and NPR4, instead of the JA receptor COI1. We provide evidence that NPR3 and NPR4 may mediate this effect by promoting degradation of the JA transcriptional repressor JAZs. This unique interplay between SA and JA offers a possible explanation of how plants can mount defence against a biotrophic pathogen without becoming vulnerable to necrotrophic pathogens.
authors.affiliation: Howard Hughes Medical Institute-Gordon and Betty Moore Foundation, Department of Biology, Duke University, Durham, North Carolina 27708, USA.
authors.forename: Lijing
authors.initials: L
authors.lastname: Liu
authors.affiliation: Howard Hughes Medical Institute-Gordon and Betty Moore Foundation, Department of Biology, Duke University, Durham, North Carolina 27708, USA.|Department of Basic Sciences, Faculty of Dentistry, Sinai University, Al Arish, North Sinai 45518, Egypt.
authors.forename: Fathi-Mohamed
authors.initials: FM
authors.lastname: Sonbol
authors.affiliation: Department of Energy Plant Research Laboratory, and Cell and Molecular Biology Program, Michigan State University, East Lansing, Michigan 48824, USA.
authors.forename: Bethany
authors.initials: B
authors.lastname: Huot
authors.affiliation: Howard Hughes Medical Institute-Gordon and Betty Moore Foundation, Department of Biology, Duke University, Durham, North Carolina 27708, USA.
authors.forename: Yangnan
authors.initials: Y
authors.lastname: Gu
authors.affiliation: Howard Hughes Medical Institute-Gordon and Betty Moore Foundation, Department of Biology, Duke University, Durham, North Carolina 27708, USA.
authors.forename: John
authors.initials: J
authors.lastname: Withers
authors.affiliation: Howard Hughes Medical Institute-Gordon and Betty Moore Foundation, Department of Biology, Duke University, Durham, North Carolina 27708, USA.
authors.forename: Musoki
authors.initials: M
authors.lastname: Mwimba
authors.affiliation: Howard Hughes Medical Institute, Department of Energy Plant Research Laboratory, and Department of Plant Biology, Michigan State University, East Lansing, Michigan 48824, USA.|Department of Biological Sciences, Western Michigan University, Kalamazoo, Michigan 49008, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Yao
authors.affiliation: Howard Hughes Medical Institute, Department of Energy Plant Research Laboratory, and Department of Plant Biology, Michigan State University, East Lansing, Michigan 48824, USA.
authors.forename: Sheng Yang
authors.initials: SY
authors.lastname: He
authors.affiliation: Howard Hughes Medical Institute-Gordon and Betty Moore Foundation, Department of Biology, Duke University, Durham, North Carolina 27708, USA.
authors.forename: Xinnian
authors.initials: X
authors.lastname: Dong
mesh_terms: D017209:Apoptosis; D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000378:metabolism*; D003517:Cyclopentanes / Q000378:metabolism*; D018506:Gene Expression Regulation, Plant; D008954:Models, Biological; D054883:Oxylipins / Q000378:metabolism*; D057865:Plant Immunity; D011485:Protein Binding; D011956:Receptors, Cell Surface / Q000378:metabolism*; D020156:Salicylic Acid / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D029681:Arabidopsis Proteins; D003517:Cyclopentanes; D054883:Oxylipins; D011956:Receptors, Cell Surface; C011006:jasmonic acid; D020156:Salicylic Acid