title: Oral health, diabetes, and body weight.
abstract: OBJECTIVE
  The effects of apical periodontitis (AP) and periodontal disease (PD) on organ weights in rats with diabetes mellitus (DM) were evaluated.
  
  
  METHODS
  Eighty male rats (Rattus norvegicus albinus, Wistar) were divided into eight groups of ten: normoglycemic (N), AP, PD, AP+PD, DM, DM+AP, DM+PD, and DM+AP+PD. DM was induced by streptozotocin; AP, by dental exposure to the oral environment; and PD, by periodontal ligature. Blood glucose concentration was measured at 0, 6, 15, and 35days; body weight, measured daily; and animals were sacrificed after 30days after induction of oral infections. Liver, kidney, pancreas, brain, heart, lungs, and gonads were each weighed. Glycemia, feed intake, organ weight, and body weight were subjected to statistical analyses (p<0.05).
  
  
  RESULTS
  Glycemic levels were higher in all diabetic groups after day 6, but were consistently similar in normoglycemic groups. Blood glucose was higher in DM+PD and DM+AP+PD groups than in the DM group at days 15 and 35. The feed intake was similar among all groups. Brain, heart, and gonad weights were significantly increased in DM+AP+PD. Kidney and lung weights were increased in DM, regardless of the presence of oral infections. Liver weight was reduced in AP and/or PD. Pancreas weight was reduced in DM, independent of AP or PD. Among the normoglycemic groups, there were no significant differences among organ weights.
  
  
  CONCLUSIONS
  Apical periodontitis and periodontal disease may potentiate the adverse effects of diabetes.
authors.affiliation: Department of Endodontics, Araçatuba Dental School, UNESP-Univ Estadual Paulista, Araçatuba, SP, Brazil. Electronic address: lucianocintra@foa.unesp.br.
authors.forename: Luciano Tavares Angelo
authors.initials: LT
authors.lastname: Cintra
authors.affiliation: Department of Endodontics, Araçatuba Dental School, UNESP-Univ Estadual Paulista, Araçatuba, SP, Brazil.
authors.forename: Renata Oliveira
authors.initials: RO
authors.lastname: Samuel
authors.affiliation: Department of Endodontics, Araçatuba Dental School, UNESP-Univ Estadual Paulista, Araçatuba, SP, Brazil.
authors.forename: Annelise Katrine Carrara
authors.initials: AK
authors.lastname: Prieto
authors.affiliation: Department of Basic Sciences, Araçatuba Dental School, Univ Estadual Paulista, Araçatuba, SP, Brazil.
authors.forename: Dóris Hissako
authors.initials: DH
authors.lastname: Sumida
authors.affiliation: Department of Endodontics, Araçatuba Dental School, UNESP-Univ Estadual Paulista, Araçatuba, SP, Brazil.
authors.forename: Eloi
authors.initials: E
authors.lastname: Dezan-Júnior
authors.affiliation: Department of Endodontics, Araçatuba Dental School, UNESP-Univ Estadual Paulista, Araçatuba, SP, Brazil.
authors.forename: João Eduardo
authors.initials: JE
authors.lastname: Gomes-Filho
mesh_terms: D000818:Animals; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D008297:Male; D009909:Oral Health; D009929:Organ Size; D010510:Periodontal Diseases / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar
keywords: Apical periodontitis; Diabetes mellitus; Organ weight; Periodontal disease