title: A novel bio-mimicking, planar nano-edge microelectrode enables enhanced long-term neural recording.
abstract: Our inability to accurately monitor individual neurons and their synaptic activity precludes fundamental understanding of brain function under normal and various pathological conditions. However, recent breakthroughs in micro- and nano-scale fabrication processes have advanced the development of neuro-electronic hybrid technology. Among such devices are three-dimensional and planar electrodes, offering the advantages of either high fidelity or longer-term recordings respectively. Here, we present the next generation of planar microelectrode arrays with "nano-edges" that enable long-term (≥1 month) and high fidelity recordings at a resolution 15 times higher than traditional planar electrodes. This novel technology enables better understanding of brain function and offers a tremendous opportunity towards the development of future bionic hybrids and drug discovery devices.
authors.affiliation: Biomedical Engineering Graduate Program, University of Calgary, Calgary, Canada.
authors.forename: Pierre
authors.initials: P
authors.lastname: Wijdenes
authors.affiliation: Department of Electrical and Computer Engineering, University of Calgary, Calgary, Canada.
authors.forename: Hasan
authors.initials: H
authors.lastname: Ali
authors.affiliation: Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.
authors.forename: Ryden
authors.initials: R
authors.lastname: Armstrong
authors.affiliation: Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.
authors.forename: Wali
authors.initials: W
authors.lastname: Zaidi
authors.affiliation: Biomedical Engineering Graduate Program, University of Calgary, Calgary, Canada.|Department of Electrical and Computer Engineering, University of Calgary, Calgary, Canada.
authors.forename: Colin
authors.initials: C
authors.lastname: Dalton
authors.affiliation: Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.|Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada.
authors.forename: Naweed I
authors.initials: NI
authors.lastname: Syed
mesh_terms: D000818:Animals; D032701:Biomimetics / Q000379:methods; D002478:Cells, Cultured; D004558:Electric Stimulation / Q000295:instrumentation / Q000379:methods; D054351:Electrical Synapses / Q000502:physiology*; D008195:Lymnaea; D008839:Microelectrodes; D008959:Models, Neurological; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*