title: Functional State of the Heart during Spontaneous Nonconvulsive Seizure Activity at Various Times of the Day.
abstract: Circadian peculiarities of HR regulation and functional capacities of the heart in WAG/Rij rats with genetically determined absence epilepsy are related to spike-wave activity of the brain. The number of spike-wave discharges (SWD) is maximum at night, early morning, and evening time and decreases to minimum at 08.00-16.00. At night, functional capacities of the heart are reduced and stress test at night induces ischemic changes in the myocardium at a lower functional load than in the daytime (low level of SWD activity). The decrease in the number of SWD and spike-wave index during the daytime contributes to the central mechanisms of autonomic regulation of the heart. However, these capacities are reduced against the background of increased seizure activity during nighttime.
authors.affiliation: Department for Anatomy and Physiology of Humans and Animals, Moscow Pedagogical State University, Moscow, Russia. mamalyga_49@mail.ru.
authors.forename: M L
authors.initials: ML
authors.lastname: Mamalyga
authors.affiliation: Department for Anatomy and Physiology of Humans and Animals, Moscow Pedagogical State University, Moscow, Russia.
authors.forename: L M
authors.initials: LM
authors.lastname: Mamalyga
mesh_terms: D000818:Animals; D058256:Brain Waves; D002316:Cardiotonic Agents / Q000494:pharmacology; D002940:Circadian Rhythm; D004280:Dobutamine / Q000494:pharmacology; D004562:Electrocardiography; D004569:Electroencephalography; D004832:Epilepsy, Absence / Q000503:physiopathology*; D006321:Heart / Q000503:physiopathology*; D006339:Heart Rate; D008297:Male; D051381:Rats
chemical_list: D002316:Cardiotonic Agents; D004280:Dobutamine
keywords: absence epilepsy; circadian rhythms; heart; spike-wave discharges; stress test