title: Calcitonin Receptor AluI (rs1801197) and Taq1 Calcitonin Genes Polymorphism in 45-and Over 45-year-old Women and their Association with Bone Density.
abstract: OBJECTIVE
  Calcitonin receptor gene has also a polymorphism which is associated with bone mass density. This study evaluates the association between calcitonin receptor AluI (rs1801197) and Taq1 calcitonin genes polymorphism with bone density rate.
  
  
  METHODS
  In this descriptive-analytical study in 2013 in southwestern Iran, 200 blood samples, per the Cochran sample size formula, were taken from women aged 45 and older. DNA was extracted from the samples using the phenol- chloroform method and the genomic fragments in question were proliferated using the polymerase chain reaction (PCR) method.
  
  
  RESULTS
  The genotypic distribution of polymorphism AluI forTT,TC, andCCgenotypes in control group was 31.4%, 38.6%, and 30% and in patients 25.4%, 55.4%, and 19.2%, respectively. There was no significant difference in polymorphism AluI between patients and control group and no significant association was found between this gene and bone density rate (P > 0.05). All patients and the individuals in the control group exhibitedttgenotype for TaqI calcitonin gene and no significant association was found between these participants and osteoporosis.
  
  
  CONCLUSIONS
  There was no association between two polymorphisms and osteoporosis, and between polymorphism of these two genes and osteoporosis development rate in the participants.
authors.affiliation: Department of Orthopedics, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Morteza
authors.initials: M
authors.lastname: Dehghan
authors.affiliation: Department of Genetics, University of Shahrekord, Shahrekord, Iran.
authors.forename: Razieh
authors.initials: R
authors.lastname: Pourahmad-Jaktaji
authors.affiliation: University of Shahrekord, Shahrekord, Iran.
authors.forename: Zarghampoor
authors.initials: Z
authors.lastname: Farzaneh
keywords: AluI calcitonin receptor gene; Polymorphism; TaqI calcitonin gene; osteoporosis