title: Ertapenem-Induced Acute Interstitial Nephritis (AIN) in a Case of Protein S Deficiency and Factor V Leiden Mutation with Deep Vein Thrombosis.
abstract: We present a case of 58 years old male patient, who presented with high fever for which injection Ertapenem was started empirically at Dubai hospital. Patient was a known case of Deep vein thrombosis of left leg since 5 years on warfarin therapy. Patient came to India for high fever and further management. Patient developed proteinuria with high creatinine and urinary abnormalities. Renal biopsy revealed acute interstitial nephritis (AIN). In addition, he was diagnosed to have protein S deficiency with Factor V Leiden mutation.
authors.affiliation: HOD, Medicine Dept., HBT Medical College & R.N. Cooper Municipal Hospital, Mumbai, Maharashtra.
authors.forename: Nitin
authors.initials: N
authors.lastname: Rathod
authors.affiliation: HOD Nephrology Dept. Nanavati Superspeciality Hospital, Mumbai, Mahrarashtra.
authors.forename: Pavan
authors.initials: P
authors.lastname: Pai
mesh_terms: D061605:Administration, Intravenous; D001706:Biopsy; D000077727:Ertapenem; D005165:Factor V / Q000235:genetics*; D005268:Femoral Vein / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D018455:Protein S Deficiency / Q000150:complications* / Q000235:genetics; D019851:Thrombophilia; D020246:Venous Thrombosis / Q000150:complications*; D047090:beta-Lactams / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D047090:beta-Lactams; C095381:factor V Leiden; D005165:Factor V; D011239:Prednisolone; D000077727:Ertapenem