title: The valuable diagnosis of DIC and pre-DIC and prediction of a poor outcome by the evaluation of diagnostic criteria for DIC in patients with hematopoietic injury established by the Japanese Society of Thrombosis and Hemostasis.
abstract: OBJECTIVE
  We evaluated the modified diagnostic criteria for disseminated intravascular coagulation (DIC), which was published by the Japanese Society of Thrombosis and Hemostasis (JSTH), in 274 suspected DIC patients with hematopoietic injury.
  
  
  METHODS
  The diagnoses of the patients were as follows: DIC (n=125); pre-DIC (n=42) and non-DIC (n=107). The efficacy of the diagnostic criteria for DIC was evaluated using a receiver operating characteristic (ROC) analysis.
  
  
  RESULTS
  The area under the curve (ARC) and odd's ratio for the global coagulation test (GCT) scores in the diagnosis of "DIC" were high, while those for the diagnosis of "DIC and pre-DIC" were low, suggesting that the addition of antithrombin (AT) and soluble fibrin (SF)/thrombin antithrobin complex (TAT) was required to diagnose "DIC and pre-DIC". Although the addition of the AT and SF/TAT values to the GCT did not increase its ability to predict a poor outcome, the JSTH's modified diagnostic criteria scores were correlated with the odds ratio for death.
  
  
  CONCLUSIONS
  The JSTH's modified diagnostic criteria for DIC, which included the GCT score, and the AT, and TAT/SF values, were useful for diagnosing DIC and pre-DIC, and predicting a poor outcome.
authors.affiliation: Department of Hematology and Oncology, Mie University Graduate School of Medicine, Mie, Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Aota
authors.affiliation: Department of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, Mie, Japan. Electronic address: wadahide@clin.medic.mie-u.ac.jp.
authors.forename: Hideo
authors.initials: H
authors.lastname: Wada
authors.affiliation: Department of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, Mie, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Fujimoto
authors.affiliation: Department of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, Mie, Japan.
authors.forename: Kazushi
authors.initials: K
authors.lastname: Sugimoto
authors.affiliation: Department of Hematology and Oncology, Mie University Graduate School of Medicine, Mie, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Yamashita
authors.affiliation: Blood Transfusion Service, Mie University Graduate School of Medicine, Mie, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Matsumoto
authors.affiliation: Blood Transfusion Service, Mie University Graduate School of Medicine, Mie, Japan.
authors.forename: Kohshi
authors.initials: K
authors.lastname: Ohishi
authors.affiliation: Emergency Critical Care Center, Mie University Graduate School of Medicine, Mie, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Suzuki
authors.affiliation: Emergency Critical Care Center, Mie University Graduate School of Medicine, Mie, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Imai
authors.affiliation: Department of Hematology, Teikyo University, Tokyo, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kawasugi
authors.affiliation: Department of Clinical Laboratory Medicine, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Madoiwa
authors.affiliation: Department of Hematology, Kanazawa University Hospital, Kanazawa, Japan.
authors.forename: Hidesaku
authors.initials: H
authors.lastname: Asakura
authors.affiliation: Department of Hematology and Oncology, Mie University Graduate School of Medicine, Mie, Japan.
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Katayama
mesh_terms: D000328:Adult; D001777:Blood Coagulation; D001780:Blood Coagulation Tests; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012372:ROC Curve; D012955:Societies, Medical
keywords: DIC; Diagnostic criteria; Hematopoietic injury; Pre-DIC