title: Bone strength and management of postmenopausal fracture risk with antiresorptive therapies: considerations for women's health practice.
abstract: Bone strength - and, hence, fracture risk - reflects the structural and material properties of the skeleton, which changes with bone turnover during aging and following effective pharmacotherapy. A variety of powerful new techniques (quantitative computed tomography, as well as peripheral quantitative computed tomography and high-resolution peripheral quantitative computed tomography) provide precise images of bone structure and can be used to model the response of specific bones to different types of mechanical load. This review explores the various components of bone strength and the clinical significance of measures, such as bone mineral density, bone turnover markers, and modern imaging data, with regard to fracture risk in women with postmenopausal osteoporosis, before and after initiating antiresorptive therapy. These imaging and related techniques offer an ever-clearer picture of the changes in bone structure and bone mineral metabolism during normal aging and in osteoporosis, as well as in response to treatment. However, because the newer techniques are not yet available in routine practice, validated tools for absolute fracture risk assessment remain essential for clinical decision making. These tools, which are tailored to patient risk data in individual countries, are based on bone mineral density and other readily available clinical data. In addition, bone turnover marker measurements can be useful in assessing risk and guiding treatment decisions for women with postmenopausal osteoporosis. Such tests may be used before starting a patient on antiresorptive therapy and for ongoing monitoring of treatment effectiveness.
authors.affiliation: Department of Medicine, University of Toronto; Centre of Excellence in Skeletal Health Assessment, Joint Department of Medical Imaging, University Health Network (UHN); Mount Sinai Hospital, University of Toronto, Toronto, ON.
authors.forename: Angela M
authors.initials: AM
authors.lastname: Cheung
authors.affiliation: Assiniboine Clinic, Winnipeg, MB.
authors.forename: Heather
authors.initials: H
authors.lastname: Frame
authors.affiliation: University Health Network, Toronto.
authors.forename: Michael
authors.initials: M
authors.lastname: Ho
authors.affiliation: Amgen Canada, Inc, Mississauga, ON.
authors.forename: Erin S
authors.initials: ES
authors.lastname: Mackinnon
authors.affiliation: Rheumatology Division, CHU de Québec Research Centre, Laval University, Quebec City, QC, Canada.
authors.forename: Jacques P
authors.initials: JP
authors.lastname: Brown
keywords: antiresorptive; bisphosphonate; bone strength; denosumab; fracture risk; postmenopausal osteoporosis