title: Optogenetic Control of Protein Function: From Intracellular Processes to Tissue Morphogenesis.
abstract: Optogenetics is an emerging and powerful technique that allows the control of protein activity with light. The possibility of inhibiting or stimulating protein activity with the spatial and temporal precision of a pulse of laser light is opening new frontiers for the investigation of developmental pathways and cell biological bases underlying organismal development. With this powerful technique in hand, it will be possible to address old and novel questions about how cells, tissues, and organisms form. In this review, we focus on the applications of existing optogenetic tools for addressing issues in animal morphogenesis.
authors.affiliation: European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, 69117 Heidelberg, Germany.
authors.forename: Giorgia
authors.initials: G
authors.lastname: Guglielmi
authors.affiliation: European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, 69117 Heidelberg, Germany.
authors.forename: Henning Johannes
authors.initials: HJ
authors.lastname: Falk
authors.affiliation: European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, 69117 Heidelberg, Germany. Electronic address: stefano.derenzis@embl.de.
authors.forename: Stefano
authors.initials: S
authors.lastname: De Renzis
mesh_terms: D000818:Animals; D002465:Cell Movement; D006801:Humans; D042541:Intracellular Space / Q000378:metabolism*; D009024:Morphogenesis; D062308:Optogenetics / Q000379:methods*; D011506:Proteins / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D011506:Proteins