title: Rhodium/bisphosphine-thiourea-catalyzed enantioselective hydrogenation of α,β-unsaturated N-acylpyrazoles.
abstract: We successfully extended our Rh/bisphosphine-thiourea (ZhaoPhos) catalytic system to asymmetric hydrogenation of α,β-unsaturated N-acylpyrazoles affording products with high yields and excellent enantioselectivities (up to 97% yield, 99% ee). The pyrazole moiety played an important role in providing H-bond acceptor sites, which is critical for achieving high reactivities and enantioselectivities.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China. xumu@whu.edu.cn xiuqindong@whu.edu.cn and College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, P. R. China. xinquan@zjut.edu.cn.
authors.forename: Pan
authors.initials: P
authors.lastname: Li
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, P. R. China. xinquan@zjut.edu.cn.
authors.forename: Xinquan
authors.initials: X
authors.lastname: Hu
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China. xumu@whu.edu.cn xiuqindong@whu.edu.cn.
authors.forename: Xiu-Qin
authors.initials: XQ
authors.lastname: Dong
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China. xumu@whu.edu.cn xiuqindong@whu.edu.cn and Department of Chemistry, South University of Science and Technology of China, Shenzhen, 518000, P. R. China.
authors.forename: Xumu
authors.initials: X
authors.lastname: Zhang