title: Reproductive/Developmental Abnormalities Induced by Epigenetic Aberrations and Possible Environmental Causes.
abstract: Foetal environmental factors, including maternal nutrition, hormonal disturbance, and chemical exposure, affect foetal growth and can cause birth defects. Recent studies have shown the link of poor foetal growth with increased risks of coronary heart disease, type II diabetes, kidney disease, and brain disorders in adulthood. Epigenetic modifications, such as DNA methylation and histone modifications, are involved in tissue- and developmental stage-specific gene expression and silencing, and they can be transmitted stably through mitotic cell division, thereby inducing long-term changes in gene regulation. Developmental programming during the foetal period, therefore, could affect adult health through epigenetic mechanisms. In fact, many studies using animal models have demonstrated that nutrient manipulation during pregnancy induces epigenetic alterations at specific loci or globally in the offspring. In this review, we summarize our findings that elucidate the effects of in utero environments on the human placental epigenome.
authors.affiliation: Department of Maternal-Fetal Biology, National Research Institute for Child Health and Development.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kawai
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Hata
mesh_terms: D000818:Animals; D001927:Brain Diseases / Q000209:etiology; D000013:Congenital Abnormalities / Q000209:etiology*; D003327:Coronary Disease / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology; D004781:Environmental Exposure / Q000009:adverse effects*; D044127:Epigenesis, Genetic / Q000235:genetics*; D005260:Female; D047109:Fetal Development; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology; D044342:Malnutrition / Q000150:complications*; D018811:Maternal Exposure / Q000009:adverse effects*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011248:Pregnancy Complications; D011297:Prenatal Exposure Delayed Effects; D012306:Risk