title: Targeted Theranostic Approach for Glioma Using Dendrimer-Based Curcumin Nanoparticle.
abstract: The delivery of anti-cancer agents to brain tumors represent a challenge because the blood-brain tumor barrier (BBTB) effectively limits the delivery of many agents. A new generation 3 (G3) dendrimer-based curcumin (Curc) conjugate was synthesized. The synthesized G3-Curc conjugate demonstrated full solubility in aqueous media. The in vitro study revealed that G3-Curc nanoparticles were internalized into glioma U-251 cells. Systemic delivery of G3-Curc conjugate led to preferentially accumulation in an orthotopic preclinical glioma model minimizing systemic toxic effect. Multicolor microscopy images of the tumor tissue showed that G3-Curc particles were internalized inside tumor cells selectively and further localized within nuclei. Enhanced bioavailability of G3-Curc conjugate was also observed with improved therapeutic efficacy against different cancers cells.
authors.affiliation: Department of Neurology, Henry Ford Hospital, Detroit, MI 48202, USA.
authors.forename: N H
authors.initials: NH
authors.lastname: Gamage
authors.affiliation: Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48202, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Jing
authors.affiliation: Department of Neurology, Henry Ford Hospital, Detroit, MI 48202, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Worsham
authors.affiliation: Department of Neurology, Henry Ford Hospital, Detroit, MI 48202, USA.
authors.forename: M M
authors.initials: MM
authors.lastname: Ali
keywords: Dendritic curcumin conjugate; Glioma specific agent; Nanotheranostic; Optical imaging