title: Oxidant signaling underlies PKGIα modulation of Ca2+ sparks and BKCa in myogenically active arterioles.
abstract: Local blood flow autoregulation in response to intraluminal pressure requires small artery myogenic vasoconstriction, the extent of which is thought to be governed by a feedback process that depends on Ca2+signaling. In this issue of Science Signaling, Khavandi et al suggest a role for cyclic guanosine monophosphate (cGMP)-dependent protein kinase G Iα (PKGIα) activated by oxidants in a cGMP-independent manner.
authors.affiliation: Dalton Cardiovascular Research Center and Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65211, USA. hillmi@missouri.edu.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Hill
authors.affiliation: Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada.
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Braun
mesh_terms: D000818:Animals; D001160:Arterioles / Q000378:metabolism*; D001783:Blood Flow Velocity / Q000502:physiology; D020013:Calcium Signaling / Q000502:physiology*; D062965:Cyclic GMP-Dependent Protein Kinase Type I / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D051037:Large-Conductance Calcium-Activated Potassium Channel alpha Subunits / Q000235:genetics / Q000378:metabolism*
chemical_list: C494841:KCNMA1 protein, human; D051037:Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; D062965:Cyclic GMP-Dependent Protein Kinase Type I