title: Characterization of a reassortant H11N9 subtype avian influenza virus isolated from bean goose along the East Asian-Australian flyway.
abstract: During the surveillance of avian influenza viruses in the Dongxi Lake wetland of Hubei in 2015-2016, an H11N9 avian influenza virus was isolated from a bean goose (Anser fabalis). Phylogenetic analysis showed that the HA gene of this isolate belongs to the North American lineage; however, the NA and the internal genes of the isolate were generated from the Eurasian lineage. This strain had reduced pathogenicity in mice and was capable of replication in the mouse lung without prior adaptation. This is the first report detecting H11N9 subtype influenza virus from migratory birds in central China. These findings highlight the transmission of avian influenza virus along the East Asian-Australian flyway and the need for continuing surveillance in central China.
authors.affiliation: Institute of Animal Husbandry and Veterinary Science, Wuhan Academy of Agricultural Science and Technology, Wuhan, 430208, Hubei, People's Republic of China.
authors.forename: Yanfeng
authors.initials: Y
authors.lastname: Yao
authors.affiliation: Institute of Animal Husbandry and Veterinary Science, Wuhan Academy of Agricultural Science and Technology, Wuhan, 430208, Hubei, People's Republic of China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Shao
authors.affiliation: Institute of Animal Husbandry and Veterinary Science, Wuhan Academy of Agricultural Science and Technology, Wuhan, 430208, Hubei, People's Republic of China.
authors.forename: Bin
authors.initials: B
authors.lastname: He
authors.affiliation: Institute of Animal Husbandry and Veterinary Science, Wuhan Academy of Agricultural Science and Technology, Wuhan, 430208, Hubei, People's Republic of China.
authors.forename: Wenhai
authors.initials: W
authors.lastname: Yang
authors.affiliation: CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology Chinese Academy of Sciences, Hubei, People's Republic of China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Chen
authors.affiliation: Ministry of Education Key Laboratory for Earth System Modelling, Center for Earth System Science Tsinghua University, Beijing, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Institute of Animal Husbandry and Veterinary Science, Wuhan Academy of Agricultural Science and Technology, Wuhan, 430208, Hubei, People's Republic of China.
authors.forename: Xiabing
authors.initials: X
authors.lastname: Chen
authors.affiliation: Institute of Animal Husbandry and Veterinary Science, Wuhan Academy of Agricultural Science and Technology, Wuhan, 430208, Hubei, People's Republic of China. xkschenjie@sina.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
mesh_terms: D025041:Animal Migration; D000818:Animals; D001208:Asia; D001315:Australia; D001715:Bird Diseases / Q000821:virology*; D005260:Female; D005777:Geese; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics; D009980:Influenza A virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000821:virology; D010802:Phylogeny; D012367:RNA, Viral; D016865:Reassortant Viruses / Q000235:genetics*; D017422:Sequence Analysis, DNA
chemical_list: D019267:Hemagglutinin Glycoproteins, Influenza Virus; D012367:RNA, Viral
keywords: Avian influenza virus; Genetic analysis; H11N9; Migratory bird; Virus reassortment