title: Anti-Inflammatory Drug Design Using a Molecular Hybridization Approach.
abstract: The design of new drugs with better physiochemical properties, adequate absorption, distribution, metabolism, and excretion, effective pharmacologic potency and lacking toxicity remains is a challenge. Inflammation is the initial trigger of several different diseases, such as Alzheimer's disease, asthma, atherosclerosis, colitis, rheumatoid arthritis, depression, cancer; and disorders such as obesity and sexual dysfunction. Although inflammation is not the direct cause of these disorders, inflammatory processes often increase related pain and suffering. New anti-inflammatory drugs developed using molecular hybridization techniques to obtain multiple-ligand drugs can act at one or multiple targets, allowing for synergic action and minimizing toxicity. This work is a review of new anti-inflammatory drugs developed using the molecular modification approach.
authors.affiliation: Lapdesf, Laboratory of Drug Design, Department of Drugs and Medicines, School of Pharmaceutical Sciences, University of São Paulo State (UNESP), Rodovia Araraquara-Jaú, km 1, Araraquara, SP, Cep. 14.802-901, Brazil. bosquesi@fcfar.unesp.br.
authors.forename: Priscila Longhin
authors.initials: PL
authors.lastname: Bosquesi
authors.affiliation: Lapdesf, Laboratory of Drug Design, Department of Drugs and Medicines, School of Pharmaceutical Sciences, University of São Paulo State (UNESP), Rodovia Araraquara-Jaú, km 1, Araraquara, SP, Cep. 14.802-901, Brazil.
authors.forename: Thais Regina Ferreira
authors.initials: TR
authors.lastname: Melo
authors.affiliation: Lapdesf, Laboratory of Drug Design, Department of Drugs and Medicines, School of Pharmaceutical Sciences, University of São Paulo State (UNESP), Rodovia Araraquara-Jaú, km 1, Araraquara, SP, Cep. 14.802-901, Brazil. ednirvizioli@yahoo.com.br.
authors.forename: Ednir Oliveira
authors.initials: EO
authors.lastname: Vizioli
authors.affiliation: Lapdesf, Laboratory of Drug Design, Department of Drugs and Medicines, School of Pharmaceutical Sciences, University of São Paulo State (UNESP), Rodovia Araraquara-Jaú, km 1, Araraquara, SP, Cep. 14.802-901, Brazil. santosjl@fcfar.unesp.br.
authors.forename: Jean Leandro Dos
authors.initials: JL
authors.lastname: Santos
authors.affiliation: Lapdesf, Laboratory of Drug Design, Department of Drugs and Medicines, School of Pharmaceutical Sciences, University of São Paulo State (UNESP), Rodovia Araraquara-Jaú, km 1, Araraquara, SP, Cep. 14.802-901, Brazil. chungmc@fcfar.unesp.br.
authors.forename: Man Chin
authors.initials: MC
authors.lastname: Chung
keywords: anti-inflammatory; hybridization; multiple-ligands; mutual prodrug