title: Redox/pH dual stimuli-responsive degradable Salecan-g-SS-poly(IA-co-HEMA) hydrogel for release of doxorubicin.
abstract: Salecan is a novel water-soluble extracellular β-glucan and possesses excellent physicochemical and biological properties. Here, redox/pH dual stimuli-responsive hydrogel based on Salecan grafted with itaconic acid (IA) and 2-hydroxyethyl methacrylate (HEMA) were prepared using disulfide-functionalized crosslinker N,N-bis(acryloyl)cystamine (BAC) for controlled drug delivery. The introduction of carboxylic groups endows the system with pH-sensitive character, swelling behavior of the hydrogel was conducted by changing the pH and Salecan content. It was demonstrated that DOX was efficiently loaded into the hydrogels and released in a controlled fashion via pH-control and swelling-shrinking mechanism. More importantly, DOX-loaded hydrogels showed dose dependent cytotoxicity toward A549 cell, and efficient cell killing was observed. Furthermore, a key point of this study was that the presence of disulfide linkage in system favored the degradation of hydrogels in the reductive environment. These results highlight the potential of Salecan-g-SS-poly(IA-co-HEMA) hydrogel as a novel system for the controlled release of anti-cancer drugs.
authors.affiliation: Jiangsu Province Biomass Energy and Materials Laboratory, Institute of Chemical Industry of Forestry Products, CAF, Nanjing 210042, China. Electronic address: huxinyulhs@163.com.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Hu
authors.affiliation: Jiangsu Province Biomass Energy and Materials Laboratory, Institute of Chemical Industry of Forestry Products, CAF, Nanjing 210042, China.
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Jiangsu Province Biomass Energy and Materials Laboratory, Institute of Chemical Industry of Forestry Products, CAF, Nanjing 210042, China.
authors.forename: Liangliang
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Jiangsu Province Biomass Energy and Materials Laboratory, Institute of Chemical Industry of Forestry Products, CAF, Nanjing 210042, China.
authors.forename: Man
authors.initials: M
authors.lastname: Xu
authors.affiliation: Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing 210094, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Dong
authors.affiliation: Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing 210094, China.
authors.forename: Jianfa
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry; D004317:Doxorubicin / Q000737:chemistry*; D016503:Drug Delivery Systems; D020100:Hydrogels; D006863:Hydrogen-Ion Concentration; D008689:Methacrylates / Q000737:chemistry*; D010084:Oxidation-Reduction; D047071:beta-Glucans / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D020100:Hydrogels; D008689:Methacrylates; D047071:beta-Glucans; C577623:salecan; C005044:hydroxyethyl methacrylate; D004317:Doxorubicin
keywords: Controlled drug delivery; Degradation; Hydrogel; Redox/pH stimuli-responsive; Salecan