title: Impact of intravesical onabotulinumtoxinA on sexual function in women with OAB.
abstract: OBJECTIVE
  Urgency urinary incontinence (UUI), and the symptoms of overactive bladder (OAB) have a negative impact on female sexual function. The aim of this study was to investigate the effect of intravesical onabotulinumtoxinA (Botox) injection on sexual function in women with OAB, using the multi domain Female Sexual Function Index (FSFI) questionnaire.
  
  
  METHODS
  Sixty-eight sexually active women with idiopathic OAB with at least one episode of UUI and ≥8 micturitions per 24 h were recruited. Patients completed the FSFI questionnaire before and 12 weeks after treatment with intravesical onabotulinumtoxinA injections. Baseline scores were compared with a control group of age-matched healthy women.
  
  
  RESULTS
  Fifty-six women completed the study. At baseline OAB patients reported decreased quality of sexual function in all domains measured with FSFI, in comparison to healthy women (median 21.8 vs. 26.3, P < 0.001). Over 90% of participants reported clinically relevant improvements in sexual function, with statistically significant changes in mean scores in all six domains.
  
  
  CONCLUSIONS
  Intravesical Botox injections provide improvement in sexual function in women with OAB. Neurourol. Urodynam. 9999:XX-XX, 2016. © 2016 Wiley Periodicals, Inc.
authors.affiliation: 2nd Chair and Department of Gynaecology, Medical University of Lublin, Lublin, Poland.
authors.forename: Pawel
authors.initials: P
authors.lastname: Miotla
authors.affiliation: Department of Epidemiology and Biostatistics, Imperial College London, London, UK.|Department of Urogynaecology, Imperial College London, London, UK.
authors.forename: Rufus
authors.initials: R
authors.lastname: Cartwright
authors.affiliation: 2nd Chair and Department of Gynaecology, Medical University of Lublin, Lublin, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Skorupska
authors.affiliation: 2nd Chair and Department of Gynaecology, Medical University of Lublin, Lublin, Poland.
authors.forename: Michal
authors.initials: M
authors.lastname: Bogusiewicz
authors.affiliation: Department of Paediatric Pulmonology and Rheumatology, Medical Univeristy of Lublin, Lublin, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Markut-Miotla
authors.affiliation: 2nd Chair and Department of Gynaecology, Medical University of Lublin, Lublin, Poland.
authors.forename: Konrad
authors.initials: K
authors.lastname: Futyma
authors.affiliation: 2nd Chair and Department of Gynaecology, Medical University of Lublin, Lublin, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Rechberger
mesh_terms: D000283:Administration, Intravesical; D000328:Adult; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012735:Sexual Dysfunction, Physiological / Q000188:drug therapy* / Q000503:physiopathology; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D053201:Urinary Bladder, Overactive / Q000188:drug therapy* / Q000503:physiopathology; D014554:Urination / Q000187:drug effects
chemical_list: D019274:Botulinum Toxins, Type A
keywords: Botox; onabotulinumtoxinA; overactive bladder; quality of life; sexual function; urgency incontinence