title: A supramolecular fluorescent vesicle based on a coordinating aggregation induced emission amphiphile: insight into the role of electrical charge in cancer cell division.
abstract: Binding of Zn2+to the coordinating supramolecular vesicle based on an aggregation induced emission amphiphile TPE-BPA immediately triggers the formation of charged vesicles. This induces vesicle fission and fluorescence reduction, suggesting a looser molecular packing in the charged vesicle membrane. Since cancer cells are highly charged, this indicates that the quick fission of cancer cells may have electrical charge origin.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Institution College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China. yunyan@pku.edu.cn jbhuang@pku.edu.cn.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Institution College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China. yunyan@pku.edu.cn jbhuang@pku.edu.cn.
authors.forename: Kangjie
authors.initials: K
authors.lastname: Shi
authors.affiliation: University of Bayreuth, Bayreuth, D-95440, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Drechsler
authors.affiliation: Department of Chemistry, Division of Biomedical Engineering, The Hong Kong University of Science & Technology, Clear Water Bay, Kowloon, Hong Kong, China. tangbz@pku.edu.cn and Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Hong Kong, China.
authors.forename: Ben Zhong
authors.initials: BZ
authors.lastname: Tang
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Institution College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China. yunyan@pku.edu.cn jbhuang@pku.edu.cn.
authors.forename: Jianbin
authors.initials: J
authors.lastname: Huang
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Institution College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China. yunyan@pku.edu.cn jbhuang@pku.edu.cn.
authors.forename: Yun
authors.initials: Y
authors.lastname: Yan
mesh_terms: D055592:Biophysical Phenomena; D002455:Cell Division; D005453:Fluorescence; D006801:Humans; D008081:Liposomes; D008563:Membrane Lipids / Q000737:chemistry*; D009369:Neoplasms / Q000737:chemistry*; D010713:Phosphatidylcholines / Q000737:chemistry*
chemical_list: D008081:Liposomes; D008563:Membrane Lipids; D010713:Phosphatidylcholines