title: Acute ampakine treatment ameliorates age-related deficits in long-term potentiation.
abstract: Memory loss observed as a consequence of aging is paralleled by a down-regulation of AMPA-type glutamate receptors (AMPARs) that mediate fast excitatory synaptic transmission. Activation of these receptors enhances long-term potentiation (LTP), a neuronal process demonstrated to be crucial for memory storage and thought to be a cellular substrate of learning and memory. In the present studies, we determined that LTP was reduced in aged rats when compared to young rats and that acute treatment with CX1846, a novel AMPAR positive allosteric modulator, fifteen minutes prior to tetanic stimulation completely reversed the significant deficit in LTP observed in aged rats. These results suggest that CX1846 might be useful for the treatment of age-related memory impairments.
authors.affiliation: RespireRx Pharmaceuticals Inc.126 Valley Road, Glen Rock, NJ 07452, USA. Electronic address: Dradin@respirerx.com.
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Radin
authors.affiliation: Morris Corporate Center III, 400 Interspace Parkway, Parsippany, NJ 07054, USA.
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhong
authors.affiliation: RespireRx Pharmaceuticals Inc.126 Valley Road, Glen Rock, NJ 07452, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Purcell
authors.affiliation: RespireRx Pharmaceuticals Inc.126 Valley Road, Glen Rock, NJ 07452, USA.
authors.forename: Arnold
authors.initials: A
authors.lastname: Lippa
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000502:physiology; D000494:Allosteric Regulation / Q000187:drug effects / Q000502:physiology; D000818:Animals; D018690:Excitatory Amino Acid Agonists / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D017774:Long-Term Potentiation / Q000187:drug effects* / Q000502:physiology; D008569:Memory Disorders / Q000188:drug therapy; D051381:Rats; D011916:Rats, Inbred F344; D018091:Receptors, AMPA / Q000819:agonists* / Q000502:physiology; D016896:Treatment Outcome
chemical_list: D018690:Excitatory Amino Acid Agonists; D018091:Receptors, AMPA
keywords: AMPA receptor; Ampakine; BDNF; Cognitive deficit; LTP; Memory formation