title: Evaluation of the Diagnostic Criteria for the Basic Type of DIC Established by the Japanese Society of Thrombosis and Hemostasis.
abstract: We evaluated the diagnostic criteria for disseminated intravascular coagulation (DIC), which was published by the Japanese Society of Thrombosis and Hemostasis (JSTH), in 232 patients with suspected DIC without hematopoietic injury or infection. The diagnoses of the patients were as follows: DIC (n = 116), pre-DIC (n = 54), and non-DIC (n = 63). The efficacy of the diagnostic criteria for DIC was evaluated using a receiver operating characteristic analysis. The area under the curve and odds ratio for the global coagulation test (GCT) scores in the diagnosis of "DIC" were high, whereas those for the diagnosis of "DIC and pre-DIC" were low, suggesting that the addition of a reduced platelet count (RPC), antithrombin (AT), and soluble fibrin (SF)/thrombin AT (TAT) complex was required to diagnose DIC and pre-DIC. When the GCT score with the RPC, AT, and TAT/SF values was used, the cutoff DIC score for the diagnosis of DIC or DIC and pre-DIC was 6 points. For predicting the outcome, a scoring system that used the GCT result was useful, but the addition of RPC, AT, or SF/TAT was not. The modified diagnostic criteria of JSTH, which included the GCT score and the RPC, AT, and TAT/SF values, were useful for diagnosing both DIC and pre-DIC.
authors.affiliation: 1 Department of Hematology and Oncology, Mie University Graduate School of Medicine, Mie, Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Aota
authors.affiliation: 2 Department of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, Mie, Japan.
authors.forename: Hideo
authors.initials: H
authors.lastname: Wada
authors.affiliation: 2 Department of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, Mie, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Fujimoto
authors.affiliation: 1 Department of Hematology and Oncology, Mie University Graduate School of Medicine, Mie, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Yamashita
authors.affiliation: 3 Blood Transfusion Service, Mie University Graduate School of Medicine, Mie, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Matsumoto
authors.affiliation: 3 Blood Transfusion Service, Mie University Graduate School of Medicine, Mie, Japan.
authors.forename: Kohshi
authors.initials: K
authors.lastname: Ohishi
authors.affiliation: 4 Emergency Critical Care Center, Mie University Graduate School of Medicine, Mie, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Suzuki
authors.affiliation: 4 Emergency Critical Care Center, Mie University Graduate School of Medicine, Mie, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Imai
authors.affiliation: 5 Department of Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Mie, Japan.
authors.forename: Masanobu
authors.initials: M
authors.lastname: Usui
authors.affiliation: 5 Department of Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Mie, Japan.
authors.forename: Shuji
authors.initials: S
authors.lastname: Isaji
authors.affiliation: 6 Department of Laboratory Medicine, Takasaki General Medical center, Takasaki, Japan.
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Uchiyama
authors.affiliation: 7 Department of Hematology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Niigata, Japan.
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Seki
authors.affiliation: 1 Department of Hematology and Oncology, Mie University Graduate School of Medicine, Mie, Japan.
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Katayama
mesh_terms: D000991:Antithrombins; D001780:Blood Coagulation Tests; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis*; D005337:Fibrin / Q000032:analysis; D006801:Humans; D007564:Japan; D010976:Platelet Count; D017410:Practice Guidelines as Topic / Q000592:standards*; D012372:ROC Curve; D012955:Societies, Medical
chemical_list: D000991:Antithrombins; D005337:Fibrin
keywords: DIC; basic type; diagnostic criteria; outcome; pre-DIC