title: Introduction of High Throughput Magnetic Resonance T2-Weighted Image Texture Analysis for WHO Grade 2 and 3 Gliomas.
abstract: Reports have suggested that tumor textures presented on T2-weighted images correlate with the genetic status of glioma. Therefore, development of an image analyzing framework that is capable of objective and high throughput image texture analysis for large scale image data collection is needed. The current study aimed to address the development of such a framework by introducing two novel parameters for image textures on T2-weighted images, i.e., Shannon entropy and Prewitt filtering. Twenty-two WHO grade 2 and 28 grade 3 glioma patients were collected whose pre-surgical MRI and IDH1 mutation status were available. Heterogeneous lesions showed statistically higher Shannon entropy than homogenous lesions (p = 0.006) and ROC curve analysis proved that Shannon entropy on T2WI was a reliable indicator for discrimination of homogenous and heterogeneous lesions (p = 0.015, AUC = 0.73). Lesions with well-defined borders exhibited statistically higher Edge mean and Edge median values using Prewitt filtering than those with vague lesion borders (p = 0.0003 and p = 0.0005 respectively). ROC curve analysis also proved that both Edge mean and median values were promising indicators for discrimination of lesions with vague and well defined borders and both Edge mean and median values performed in a comparable manner (p = 0.0002, AUC = 0.81 and p < 0.0001, AUC = 0.83, respectively). Finally, IDH1 wild type gliomas showed statistically lower Shannon entropy on T2WI than IDH1 mutated gliomas (p = 0.007) but no difference was observed between IDH1 wild type and mutated gliomas in Edge median values using Prewitt filtering. The current study introduced two image metrics that reflect lesion texture described on T2WI. These two metrics were validated by readings of a neuro-radiologist who was blinded to the results. This observation will facilitate further use of this technique in future large scale image analysis of glioma.
authors.affiliation: Department of Neurosurgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
authors.forename: Manabu
authors.identifier: http://orcid.org/0000-0001-7923-6902
authors.initials: M
authors.lastname: Kinoshita
authors.affiliation: Department of Radiology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
authors.forename: Mio
authors.initials: M
authors.lastname: Sakai
authors.affiliation: Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Arita
authors.affiliation: Division of Stem Cell Research, Institute for Clinical Research, Osaka National Hospital, Osaka, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Shofuda
authors.affiliation: Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Chiba
authors.affiliation: Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Kagawa
authors.affiliation: Department of Radiology, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Watanabe
authors.affiliation: Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan.|Department of Neurosurgery, Kyoto Prefectural University Graduate School of Medical Science, Kyoto, Japan.
authors.forename: Naoya
authors.initials: N
authors.lastname: Hashimoto
authors.affiliation: Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Fujimoto
authors.affiliation: Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Toshiki
authors.initials: T
authors.lastname: Yoshimine
authors.affiliation: Department of Radiology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Nakanishi
authors.affiliation: Division of Regenerative Medicine, Institute for Clinical Research, Osaka National Hospital, Osaka, Japan.|Department of Neurosurgery, Osaka National Hospital, Osaka, Japan.
authors.forename: Yonehiro
authors.initials: Y
authors.lastname: Kanemura
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D005910:Glioma / Q000175:diagnosis* / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D055815:Young Adult
chemical_list: D003287:Contrast Media