title: Glassworts as Possible Anticancer Agents Against Human Colorectal Adenocarcinoma Cells with Their Nutritive, Antioxidant and Phytochemical Profiles.
abstract: In this study, the possible uses of glassworts as potential food ingredients and their antiproliferative activity against colorectal adenocarcinoma cells together with their antioxidant and phytochemical profiles were investigated for the first time. MeOH extracts of five different taxa collected from different localities were screened for their antioxidant capacities by DPPH (IC502.91 - 5.49 mg/ml) and ABTS (24.4 - 38.5 μmol TE/g extract) assays. Salicornia freitagii exhibited the highest DPPH radical scavenging activity. LC/MS/MS analysis displayed that vanillic acid and p-coumaric acid were two main phenolic compounds in the extract. Salicornia freitagii extracts also exhibited high antiproliferative activity against HT-29 (IC501.67 mg/ml) and Caco-2 (IC503.03 mg/ml) cells for 72 h. Mineral analysis indicated that all the species with different proportions of elemental components contained high amount of cations. These results indicate that investigated glassworts, with their high phenolic and mineral contents and also notable antioxidant and cytotoxic properties, may be utilized as a promising source of therapeutics.
authors.affiliation: Department of Chemistry, Faculty of Science, Erzincan Univesity, 24100, Erzincan, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Altay
authors.affiliation: Food and Nutrition Technology Division, Family and Consumer Sciences Department, Gazi University Industrial Arts Education Faculty, 06500, Teknikokullar, Ankara, Turkey.
authors.forename: Gulcin Sagdicoglu
authors.initials: GS
authors.lastname: Celep
authors.affiliation: Department of Biology, Faculty of Science, Ankara University, 06100, Ankara, Turkey.
authors.forename: Ahmet E
authors.initials: AE
authors.lastname: Yaprak
authors.affiliation: Department of Biology, Faculty of Science, Ankara University, 06100, Ankara, Turkey.
authors.forename: Isa
authors.initials: I
authors.lastname: Baskose
authors.affiliation: Food Engineering Department, Middle East Technical Univesity, 06800, Ankara, Turkey.
authors.forename: Faruk
authors.initials: F
authors.lastname: Bozoglu
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D018938:Caco-2 Cells; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D019663:Chenopodiaceae / Q000737:chemistry* / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000473:pathology; D005419:Flavonoids / Q000032:analysis / Q000737:chemistry; D019073:HT29 Cells; D006801:Humans; D010636:Phenols / Q000032:analysis / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D053719:Tandem Mass Spectrometry
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts
keywords: Antioxidants; Colon cancer; Cytotoxicity; Glassworts; Minerals