title: Use of aerosol route to fabricate positively charged Au/Fe3O4Janus nanoparticles as multifunctional nanoplatforms.
abstract: Gold (Au)-decorated iron oxide (Fe3O4), Au/Fe3O4, Janus nanoparticles were fabricated via the continuous route for aerosol Au incorporation with Fe3O4domains synthesized in an aqueous medium as multifunctional nanoplatforms. The fabricated nanoparticles were subsequently exposed to 185-nm UV light to generate positive charges on Au surfaces, and their activities were tested in computed tomography (CT) and magnetic resonance (MR) imaging, gene-delivery and photothermal therapy. No additional polymeric coatings of the Janus particles also had a unique ability to suppress inflammatory responses in macrophages challenged with lipopolysaccharide, which may be due to the absence of amine groups.
authors.affiliation: School of Mechanical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea.
authors.forename: Jeong Hoon
authors.initials: JH
authors.lastname: Byeon
authors.affiliation: School of Health Sciences, Purdue University, IN 47907, United States.
authors.forename: Jae Hong
authors.initials: JH
authors.lastname: Park