title: The Ventral Pallidum: Proposed Integrator of Positive and Negative Factors in Cocaine Abuse.
abstract: In this issue of Neuron, Creed et al. (2016) describe how cocaine produces divergent forms of plasticity at synapses between specific neurons in nucleus accumbens and ventral pallidum, and how these changes are associated with positive and negative reward behaviors.
authors.affiliation: Brain Health Institute, Rutgers University/Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854, USA. Electronic address: morgan.james@rutgers.edu.
authors.forename: Morgan H
authors.initials: MH
authors.lastname: James
authors.affiliation: Brain Health Institute, Rutgers University/Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854, USA. Electronic address: aston.jones@rutgers.edu.
authors.forename: Gary
authors.initials: G
authors.lastname: Aston-Jones
mesh_terms: D066187:Basal Forebrain; D003042:Cocaine; D019970:Cocaine-Related Disorders; D005917:Globus Pallidus; D006801:Humans; D009714:Nucleus Accumbens; D017207:Rats, Sprague-Dawley
chemical_list: D003042:Cocaine
keywords: anhedonia; drug-evoked synaptic plasticity; medium spiny neurons; reward; sensitization; ventral tegmental area