title: Impact of a novel synbiotic supplementation during gestation and lactation on immune responses in the Swiss albino mice offspring.
abstract: BACKGROUND
  Prebiotics from various regularly consumed cereals and novel substrates are currently being utilised as functional foods. The aim of this study was to determine the effect of synbiotic, formulated with prebiotic extracted from natural resources like green gram (Vigna radiata) along with probiotic Lactobacillus rhamnosus GG (LGG) in modulating immune responses in the offspring when supplemented during gestation and lactation.
  
  
  RESULTS
  Synbiotic supplementation was effective in improving cell mediated immunity and humoral immunity among F0 dams. Among F1 pups (F1 Syn + and F1 Syn-), synbiotic supplementation showed significantly heightened (P < 0.05) splenocyte proliferation, increased interleukin-10, interferon gamma and interleukin-17 responses, leucocyte phagocytic ability and increased secretory-immunoglobulin A. However, four-fold increase in IgG titres to Hepatitis-B vaccine was observed only in those mice that were supplemented with synbiotic postweaning (F1 Syn+).
  
  
  CONCLUSIONS
  Synbiotic supplementation to pregnant dams affected the offspring's cellular and mucosal immunity favorably. However, IgG response to Hepatitis-B vaccine was influenced positively only when the supplementation was extended to the offsprings in the post weaning period. © 2016 Society of Chemical Industry.
authors.affiliation: Department of Clinical Microbiology & Immunology, National Institute of Nutrition (ICMR), Jamai-Osmania, Hyderabad, 500 007, Telangana, India.
authors.forename: Himaja
authors.initials: H
authors.lastname: Nallagatla
authors.affiliation: Department of Clinical Microbiology & Immunology, National Institute of Nutrition (ICMR), Jamai-Osmania, Hyderabad, 500 007, Telangana, India.
authors.forename: Rajkumar
authors.initials: R
authors.lastname: Hemalatha
authors.affiliation: Department of Clinical Microbiology & Immunology, National Institute of Nutrition (ICMR), Jamai-Osmania, Hyderabad, 500 007, Telangana, India.
authors.forename: Narendra Babu
authors.initials: NB
authors.lastname: Kondapalli
authors.affiliation: Department of Clinical Microbiology & Immunology, National Institute of Nutrition (ICMR), Jamai-Osmania, Hyderabad, 500 007, Telangana, India.
authors.forename: Shujauddin
authors.initials: S
authors.lastname: Mohammed
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D019587:Dietary Supplements / Q000032:analysis*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D056724:Immunity, Humoral / Q000187:drug effects*; D007112:Immunity, Maternally-Acquired; D016753:Interleukin-10 / Q000276:immunology; D020381:Interleukin-17 / Q000276:immunology; D007774:Lactation / Q000187:drug effects* / Q000276:immunology; D052201:Lacticaseibacillus rhamnosus / Q000502:physiology; D008297:Male; D051379:Mice; D010375:Pedigree; D056692:Prebiotics / Q000008:administration & dosage; D011247:Pregnancy / Q000187:drug effects / Q000276:immunology*; D019936:Probiotics / Q000008:administration & dosage; D058616:Synbiotics / Q000008:administration & dosage*; D000070658:Vigna / Q000737:chemistry
chemical_list: D020381:Interleukin-17; D056692:Prebiotics; D016753:Interleukin-10
keywords: Lactobacillus rhamnosus GG; fetal immunoprogramming; hepatitis-B vaccine; phagocytosis; synbiotics; whole green gram