title: Development of electroactive nanofibers based on thermoplastic polyurethane and poly(o-ethoxyaniline) for biological applications.
abstract: Electroactive nanofibers based on thermoplastic polyurethane (TPU) and poly(alkoxy anilines) produced by electrospinning has been explored for biomaterials applications. The thermoplastic polyurethane is a biocompatible polymer with good mechanical properties. The production of TPU nanofibers requires the application of high voltage during electrospinning in order to prepare uniform mats due to its weak ability to elongate during the process. To overcome this limitation, a conductive polymer can be incorporated to the process, allowing generates mats without defects. In this study, poly(o-ethoxyaniline) POEA doped with dodecylbenzene sulfonic acid (DBSA) was blended with thermoplastic polyurethane (TPU) by solution method. Films were produced by casting and nanofibers were prepared by electrospinning. The effect of the POEA on morphology, distribution of diameter and cell viability of the nanofibers was evaluated. The results demonstrated that the incorporation of POEA in TPU provided to the mats a suitable morphology for cellular growth. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 601-607, 2017.
authors.affiliation: Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo, Talim 330, Vila Nair, 12232-280, São José dos Campos, São Paulo, SP, Brazil.
authors.forename: Karina Ferreira Noronha
authors.initials: KF
authors.lastname: Cruz
authors.affiliation: Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo, Talim 330, Vila Nair, 12232-280, São José dos Campos, São Paulo, SP, Brazil.
authors.forename: Daniela Maria Ducatti
authors.initials: DM
authors.lastname: Formaggio
authors.affiliation: Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo, Talim 330, Vila Nair, 12232-280, São José dos Campos, São Paulo, SP, Brazil.
authors.forename: Dayane Batista
authors.initials: DB
authors.lastname: Tada
authors.affiliation: Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo, Talim 330, Vila Nair, 12232-280, São José dos Campos, São Paulo, SP, Brazil.
authors.forename: Fernando Henrique
authors.initials: FH
authors.lastname: Cristovan
authors.affiliation: Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo, Talim 330, Vila Nair, 12232-280, São José dos Campos, São Paulo, SP, Brazil.
authors.forename: Lilia Müller
authors.initials: LM
authors.lastname: Guerrini
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D001557:Benzenesulfonates / Q000737:chemistry*; D057139:Nanofibers / Q000737:chemistry*; D011140:Polyurethanes / Q000737:chemistry*
chemical_list: D000814:Aniline Compounds; D001557:Benzenesulfonates; D011140:Polyurethanes; C416807:polyaniline; C001114:dodecylbenzenesulfonic acid
keywords: cell viability; electrospinning; poly(o-ethoxyaniline); thermoplastic polyurethane