title: Mean platelet volume in children with hepatitis A.
abstract: Mean platelet volume (MPV), which is commonly used as a measure of platelet size, indicates the rate of platelet production and platelet activation. We aimed to evaluate the mean platelet volume in children with hepatitis A.
  
  
  
  In this retrospective case-controlled study, the study population consisted of 62 children with hepatitis A and 62 healthy control subjects.
  
  
  
  MPV values, aspartate transaminase (AST), and alanine transaminase (ALT) levels on admission were significantly increased in patients with hepatitis A when compared to controls whereas white blood cell (WBC) counts were significantly lower. Two weeks after admission, the MPV values showed a significant decrease from 9.47 ± 1.62 to 8.84 ± 1.48 fL in patients with hepatitis A, but these values were still significantly higher than the controls. There was a significant difference in terms of MPV, WBC, AST, and ALT values between the controls and the patient group 2 weeks after admission.
  
  
  
  This study is the first to evaluate the MPV levels in children with hepatitis A. MPV values were found to be increased in children hospitalized with hepatitis A.
authors.affiliation: Department of Pediatrics, Necmettin Erbakan University, Meram Medical Faculty, 42080, Konya, Turkey. drfatihakin@gmail.com.
authors.forename: Fatih
authors.identifier: 0000-0001-5725-3867
authors.initials: F
authors.lastname: Akın
authors.affiliation: Department of Pediatric Cardiology, Konya Training and Research Hospital, Konya, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Sert
authors.affiliation: Department of Pediatric Nephrology, Konya Training and Research Hospital, Konya, Turkey.
authors.forename: Şükrü
authors.initials: Ş
authors.lastname: Arslan
mesh_terms: D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001792:Blood Platelets; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006506:Hepatitis A / Q000097:blood*; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D063847:Mean Platelet Volume; D015539:Platelet Activation; D012189:Retrospective Studies
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
keywords: Child; Cytokines; Inflammation; Viral infection