title: Aspirin-Exacerbated Respiratory Disease as an Endotype of Chronic Rhinosinusitis.
abstract: Aspirin-Exacerbated Respiratory Disease (AERD) and Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) are both characterized by the presence of chronic sinonasal inflammation and nasal polyps. Unlike in CRSwNP, AERD patients develop respiratory reactions following ingestion of COX-1 inhibitors. AERD patients also, on average, have worse upper respiratory disease with increased sinonasal symptoms, mucosal inflammation and requirements for revision sinus surgery when compared to CRSwNP patients. While no single genetic factor has been identified in either CRSwNP or AERD to date, differences in the metabolism of arachidonic acid as well as innate immune cell activation may uniquely contribute to AERD pathogenesis.
authors.affiliation: Division of Allergy-Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, 240 E. Huron St, Chicago, IL 60611, USA.
authors.forename: Whitney W
authors.initials: WW
authors.lastname: Stevens
authors.affiliation: Division of Allergy-Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, 240 E. Huron St, Chicago, IL 60611, USA; Department of Otolaryngology, Northwestern University Feinberg School of Medicine, 675 N St. Clair St Suite 15-200, Chicago, IL 60611, USA. Electronic address: rpschleimer@northwestern.edu.
authors.forename: Robert P
authors.initials: RP
authors.lastname: Schleimer
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D002908:Chronic Disease; D006801:Humans; D012140:Respiratory Tract Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology*; D012220:Rhinitis / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D012852:Sinusitis / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin
keywords: AERD; Aspirin-exacerbated respiratory disease; CRSwNP; Chronic rhinosinusitis; Chronic rhinosinusitis with nasal polyps; Samter disease; Samter triad