title: A 5-item frailty index based on NSQIP data correlates with outcomes following paraesophageal hernia repair.
abstract: Frailty is a measure of physiologic reserve associated with increased vulnerability to adverse outcomes following surgery in older adults. The 'accumulating deficits' model of frailty has been applied to the NSQIP database, and an 11-item modified frailty index (mFI) has been validated. We developed a condensed 5-item frailty index and used this to assess the relationship between frailty and outcomes in patients undergoing paraesophageal hernia (PEH) repair.
  
  
  
  The NSQIP database was queried for ICD-9 and CPT codes associated with PEH repair. Subjects ≥60 years who underwent PEH repair between 2011 and 2013 were included. Five of the 11 mFI items present in the NSQIP data on the most consistent basis were selected for the condensed index. Univariate and multivariate logistic regressions were used to determine the validity of the 5-item mFI as a predictor of postoperative mortality, complications, readmission, and non-routine discharge.
  
  
  
  A total of 3711 patients had data for all variables in the 5-item index, while 885 patients had complete data to calculate the 11-item mFI. After controlling for competing risk factors, including age, ASA score, wound classification, surgical approach, and procedure timing (emergent vs non-emergent), we found the 5-item mFI remained predictive of 30-day mortality and patients being discharged to a location other than home (p < 0.05). A weighted Kappa was calculated to assess agreement between the 5-item and 11-item mFI and was found to be 0.8709 (p < 0.001).
  
  
  
  Frailty, as assessed by the 5-item mFI, is a reasonable alternative to the 11-item mFI in patients undergoing PEH repair. Utilization of the 5-item mFI allows for a significantly increased sample size compared to the 11-item mFI. Further study is necessary to determine whether the condensed 5-item mFI is a valid measure to assess frailty for other types of surgery.
authors.affiliation: Division of General Surgery, Department of Surgery, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI, 53226, USA.
authors.forename: Munyaradzi
authors.initials: M
authors.lastname: Chimukangara
authors.affiliation: Division of General Surgery, Department of Surgery, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI, 53226, USA.
authors.forename: Melissa C
authors.initials: MC
authors.lastname: Helm
authors.affiliation: Division of General Surgery, Department of Surgery, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI, 53226, USA.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Frelich
authors.affiliation: Division of General Surgery, Department of Surgery, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI, 53226, USA.
authors.forename: Matthew E
authors.initials: ME
authors.lastname: Bosler
authors.affiliation: Department of Biostatistics, Medical College of Wisconsin, Milwaukee, WI, USA.
authors.forename: Lisa E
authors.initials: LE
authors.lastname: Rein
authors.affiliation: Department of Biostatistics, Medical College of Wisconsin, Milwaukee, WI, USA.
authors.forename: Aniko
authors.initials: A
authors.lastname: Szabo
authors.affiliation: Division of General Surgery, Department of Surgery, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI, 53226, USA. jgould@mcw.edu.
authors.forename: Jon C
authors.initials: JC
authors.lastname: Gould
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016208:Databases, Factual; D005260:Female; D016330:Frail Elderly; D000073496:Frailty / Q000175:diagnosis*; D015577:Geriatric Assessment / Q000379:methods*; D006551:Hernia, Hiatal / Q000601:surgery*; D059685:Herniorrhaphy / Q000009:adverse effects; D006801:Humans; D038801:International Classification of Diseases; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D010351:Patient Discharge; D011183:Postoperative Complications / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index
keywords: Frailty; Geriatric; NSQIP; Outcomes; Paraesophageal hernia