title: Metal II complexes of ethambutol as good enzyme inhibitor and promising antioxidant.
abstract: Ethambutoldihydrogenchloride (EMB) with chemical formula C10H24N2O2.2HCl is ethane-1,2-diamine in which one hydrogen attached to each of the nitrogen is substituted by a 1-hydroxybutan-2-yl group (S,S-configuration). It is an FDA approved drug and has been used for treatment of tuberculosis since 1960's. Prolong use of EMB has a side effect of visual impairment and in literature it is related with the depletion of Zn metal from the body. As it is a good chelating agent, many metal II complexes have been synthesized with anti-tubercular activity. The purpose of this work was to synthesize metal II complexes of EMB and to evaluate their antioxidant activity along with enzyme inhibition activity (acetylcholine esterase and protease). The metals used for complex formation were Co, Zn, Fe, Cu and Ni. IR spectral data and physical parameters supported the complex formation. The obtained results showed the synthesized complexes as notable antioxidants and enzyme inhibitors.
authors.affiliation: Department of Chemistry, GC University, Lahore, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Jahangir
authors.affiliation: Department of Chemistry, GC University, Lahore, Pakistan.
authors.forename: Ume
authors.initials: U
authors.lastname: Farwa
authors.affiliation: Department of Chemistry, GC University, Lahore, Pakistan.
authors.forename: Farhana
authors.initials: F
authors.lastname: Mazhar
authors.affiliation: Department of Chemistry, GC University, Lahore, Pakistan.
authors.forename: Afza
authors.initials: A
authors.lastname: Malik
authors.affiliation: Department of Chemistry, GC University, Lahore, Pakistan.
authors.forename: Ejaz
authors.initials: E
authors.lastname: Ahmad
mesh_terms: D000110:Acetylcholinesterase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry; D002712:Chlorides / Q000737:chemistry; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology; D004977:Ethambutol / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*; D005290:Ferric Compounds / Q000737:chemistry; D006801:Humans; D010084:Oxidation-Reduction; D010851:Picrates / Q000737:chemistry; D011480:Protease Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D000995:Antitubercular Agents; D001713:Biphenyl Compounds; D002712:Chlorides; D002800:Cholinesterase Inhibitors; D005290:Ferric Compounds; D010851:Picrates; D011480:Protease Inhibitors; D004977:Ethambutol; C004931:1,1-diphenyl-2-picrylhydrazyl; D000110:Acetylcholinesterase; C024555:ferric chloride