title: Breast Cancer Sentinel Node Detection: An Alternative Solution for Centers Lacking Nuclear Technology.
abstract: BACKGROUND
  Sentinel lymph node (SLN) has become the gold standard for all cases with no axillary nodal metastasis. The combined radioisotope and blue dye technique is adopted in most centers. The lack of the technology for radioisotope in our institution encouraged us to study the feasibility of methylene blue (MB) for SLN detection in breast cancer patients admitted to Alexandria Surgical Oncology Unit.
  
  
  METHODS
  A total of 144 cases were subjected to SLN detection by injecting 2 ml of MB 1%. This was followed by standard axillary lymph node dissection. The safety and accuracy of MB as a tracer for detection of SLN were studied.
  
  
  RESULTS
  The identification rate was 93.15%. The number of SLN identified ranged from 1 to 8 nodes with a mean of 1.75 ± 1.17. The sensitivity of MB dye technique was 96.3%. The false negative rate was 3.7%. The negative predictive value was 97.6% and the accuracy was 98.5%.
  
  
  CONCLUSIONS
  MB is a safe, reliable, cheap, and accurate alternative tracer for detection of SLN.
authors.affiliation: Surgical Oncology Unit, Faculty of Medicine, Alexandria University, Alexandria, Egypt, Alexandria, Egypt.
authors.forename: Mahmoud A
authors.initials: MA
authors.lastname: Alhussini
authors.affiliation: Surgical Oncology Unit, Faculty of Medicine, Alexandria University, Alexandria, Egypt, Alexandria, Egypt.
authors.forename: Ahmed T
authors.initials: AT
authors.lastname: Awad
authors.affiliation: Surgery Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.
authors.forename: Mohamed H
authors.initials: MH
authors.lastname: Ashour
authors.affiliation: Surgical Oncology Unit, Faculty of Medicine, Alexandria University, Alexandria, Egypt, Alexandria, Egypt.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Abdelateef
authors.affiliation: Surgical Oncology Unit, Faculty of Medicine, Alexandria University, Alexandria, Egypt, Alexandria, Egypt.
authors.forename: Haytham
authors.initials: H
authors.lastname: Fayed
keywords: Methylene blue; SNB