title: Manufacturing Methods for Liposome Adjuvants.
abstract: A wide range of studies have shown that liposomes can act as suitable adjuvants for a range of vaccine antigens. Properties such as their amphiphilic character and biphasic nature allow them to incorporate antigens within the lipid bilayer, on the surface, or encapsulated within the inner core. However, appropriate methods for the manufacture of liposomes are limited and this has resulted in issues with cost, supply, and wider scale application of these systems. Within this chapter we explore manufacturing processes that can be used for the production of liposomal adjuvants, and we outline new manufacturing methods can that offer fast, scalable, and cost-effective production of liposomal adjuvants.
authors.affiliation: Schol of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK. y.perrie@aston.ac.uk.|Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, G4 0RE, UK. y.perrie@aston.ac.uk.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Perrie
authors.affiliation: Schol of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Kastner
authors.affiliation: Aston Pharmacy School, School of Life and Health Sciences, Aston University, Birmingham, B4 7ET, UK.
authors.forename: Swapnil
authors.initials: S
authors.lastname: Khadke
authors.affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, G4 0RE, UK.
authors.forename: Carla B
authors.initials: CB
authors.lastname: Roces
authors.affiliation: Aston Pharmacy School, School of Life and Health Sciences, Aston University, Birmingham, B4 7ET, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Stone
mesh_terms: D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000737:chemistry*; D008081:Liposomes
chemical_list: D000276:Adjuvants, Immunologic; D008081:Liposomes
keywords: Adjuvants; Delivery system; Liposomes; Manufacturing; Preparation; Subunit vaccine