title: Intravitreal ziv-aflibercept for macular edema following retinal vein occlusion.
abstract: OBJECTIVE
  To report the efficacy of intravitreal ziv-aflibercept injections in eyes with macular edema due to retinal vein occlusions (RVOs).
  
  
  METHODS
  Consecutive patients with persistent or recurrent macular edema (central macula thickness >250 μm) due to RVO were enrolled in this prospective study. Study eyes received intravitreal injections of ziv-aflibercept (1.25 mg/0.05 mL) at baseline. Patients were reassessed monthly for 4 months and given additional injections pro re nata for worsening best-corrected visual acuity (BCVA), intraretinal edema or subretinal fluid seen on spectral domain optical coherence tomography, or central macular thickness (CMT) measurements >250 μm. The primary endpoint was improvement in mean CMT at 4 months. Secondary endpoints included improvement in mean BCVA, and ocular and systemic safety signals.
  
  
  RESULTS
  Nine eyes (five central and four branch RVOs) of nine patients were enrolled. The mean ± standard deviation CMT decreased from 604±199 μm at baseline to 319±115 μm (P=0.001) at 1 month and to 351±205 μm (P=0.026) at 4 months. The mean BCVA did not improve significantly from baseline (1.00 LogMAR) to the 1-month (0.74 LogMAR; P=0.2) and 4-month (0.71 LogMAR; P=0.13) visits. No safety signals were noted.
  
  
  CONCLUSIONS
  In this small prospective study, intravitreal ziv-aflibercept significantly improved mean CMT in eyes with persistent or recurrent macular edema due to RVOs. Prospective, randomized trials comparing ziv-aflibercept with standard pharmacotherapy are needed to better define efficacy and safety.
authors.affiliation: Smt. Kanuri Santhamma Centre for Vitreoretinal Diseases, LV Prasad Eye Institute, Hyderabad, India.
authors.forename: Remya
authors.initials: R
authors.lastname: Paulose
authors.affiliation: Smt. Kanuri Santhamma Centre for Vitreoretinal Diseases, LV Prasad Eye Institute, Hyderabad, India.
authors.forename: Jay
authors.initials: J
authors.lastname: Chhablani
authors.affiliation: Smt. Kanuri Santhamma Centre for Vitreoretinal Diseases, LV Prasad Eye Institute, Hyderabad, India.
authors.forename: Chintan J
authors.initials: CJ
authors.lastname: Dedhia
authors.affiliation: Department of Ophthalmology, Mayo Clinic, Jacksonville, FL, USA.
authors.forename: Michael W
authors.initials: MW
authors.lastname: Stewart
authors.affiliation: Department of Ophthalmology, American University of Beirut; Department of Ophthalmology, Rafic Hariri University Hospital, Beirut, Lebanon.
authors.forename: Ahmad M
authors.initials: AM
authors.lastname: Mansour
keywords: cystoid macular edema; retinal vein occlusion; ziv-aflibercept