title: Transcriptional control by G-quadruplexes: In vivo roles and perspectives for specific intervention.
abstract: G-quadruplexes are non-canonical DNA secondary structures involved in several genomic and molecular processes. Here, we summarize the main G-quadruplex features and evidences proving the in vivo role on the transcriptional regulation of genes required for zebrafish embryonic development. We also discuss alternative strategies for specifically interfering G-quadruplex in vivo.
authors.affiliation: a Instituto de Biología Molecular y Celular de Rosario (IBR), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) - Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario (UNR), Ocampo y Esmeralda , Rosario , Argentina.
authors.forename: Pablo
authors.initials: P
authors.lastname: Armas
authors.affiliation: a Instituto de Biología Molecular y Celular de Rosario (IBR), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) - Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario (UNR), Ocampo y Esmeralda , Rosario , Argentina.
authors.forename: Aldana
authors.initials: A
authors.lastname: David
authors.affiliation: a Instituto de Biología Molecular y Celular de Rosario (IBR), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) - Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario (UNR), Ocampo y Esmeralda , Rosario , Argentina.
authors.forename: Nora B
authors.initials: NB
authors.lastname: Calcaterra
mesh_terms: D000818:Animals; D004247:DNA / Q000737:chemistry*; D054856:G-Quadruplexes; D018507:Gene Expression Regulation, Developmental; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D014158:Transcription, Genetic; D015027:Zebrafish / Q000196:embryology* / Q000235:genetics
chemical_list: D004247:DNA
keywords: antisense; embryonic development; noggin3; oligonucleotide; zebrafish