title: Methods to Prepare Aluminum Salt-Adjuvanted Vaccines.
abstract: Many human vaccines contain certain insoluble aluminum salts such as aluminum oxyhydroxide and aluminum hydroxyphosphate as vaccine adjuvants to boost the immunogenicity of the vaccines. Aluminum salts have been used as vaccine adjuvants for decades and have an established, favorable safety profile. However, preparing aluminum salts and aluminum salt-adjuvanted vaccines in a consistent manner remains challenging. This chapter discusses methods to prepare aluminum salts and aluminum salt-adjuvanted vaccines, factors to consider during preparation, and methods to characterize the vaccines after preparation.
authors.affiliation: Pharmaceutics Division, College of Pharmacy, The University of Texas at Austin, Austin, TX, 78712, USA.
authors.forename: Sachin G
authors.initials: SG
authors.lastname: Thakkar
authors.affiliation: Pharmaceutics Division, College of Pharmacy, The University of Texas at Austin, Austin, TX, 78712, USA. zhengrong.cui@austin.utexas.edu.|Dell Pediatric Research Institute, The University of Texas at Austin, 1400 Barbara Jordan Boulevard, Austin, TX, 78723, USA. zhengrong.cui@austin.utexas.edu.
authors.forename: Zhengrong
authors.initials: Z
authors.lastname: Cui
mesh_terms: D000276:Adjuvants, Immunologic / Q000737:chemistry*; D000535:Aluminum / Q000737:chemistry*; D017607:Aluminum Compounds / Q000737:chemistry*; D000818:Animals; D006801:Humans; D010710:Phosphates / Q000737:chemistry*; D014612:Vaccines / Q000737:chemistry*
chemical_list: D000276:Adjuvants, Immunologic; D017607:Aluminum Compounds; D010710:Phosphates; D014612:Vaccines; D000535:Aluminum
keywords: Aluminum hydroxyphosphate; Aluminum oxyhydroxide; Antigen adsorption; Antigen evaluation; In situ precipitation; Vaccine adjuvants