title: The Gut Microbiome as Therapeutic Target in Central Nervous System Diseases: Implications for Stroke.
abstract: Research on commensal microbiota and its contribution to health and disease is a new and very dynamically developing field of biology and medicine. Recent experimental and clinical investigations underscore the importance of gut microbiota in the pathogenesis and course of stroke. Importantly, microbiota may influence the outcome of cerebral ischemia by modulating central nervous system antigen-specific immune responses. In this review we summarize studies linking gut microbiota with physiological function and disorders of the central nervous system. Based on these insights we speculate about targeting the gut microbiome in order to treat stroke.
authors.affiliation: Department of Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.|NeuroCure Clinical Research, Charité - Universitätsmedizin Berlin, Berlin, Germany.|Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Winek
authors.affiliation: Department of Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.|NeuroCure Clinical Research, Charité - Universitätsmedizin Berlin, Berlin, Germany.|Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany.|Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.|German Center for Neurodegeneration Research (DZNE), partner site Berlin, Berlin, Germany.|German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Dirnagl
authors.affiliation: Department of Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany. andreas.meisel@charite.de.|NeuroCure Clinical Research, Charité - Universitätsmedizin Berlin, Berlin, Germany. andreas.meisel@charite.de.|Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany. andreas.meisel@charite.de.|Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany. andreas.meisel@charite.de.
authors.forename: Andreas
authors.initials: A
authors.lastname: Meisel
mesh_terms: D000818:Animals; D001921:Brain / Q000382:microbiology*; D002493:Central Nervous System Diseases / Q000382:microbiology* / Q000628:therapy*; D000069196:Gastrointestinal Microbiome / Q000502:physiology*; D006801:Humans; D064307:Microbiota / Q000502:physiology
keywords: Gut microbiota; brain–gut microbiota axis; central nervous system; stroke; therapeutic target