title: Colon cancer targeting using conjugates biomaterial 5-flurouracil.
abstract: There has been several research works on the development of an oral delivery system to deliver cytotoxic and chemo preventive agents directly at the targeted site of action with reduced unwanted side effects. The efficacy of the site-specific delivery system of a drug to colon has been proven to increase the drugs concentration at the target site, and thus requires a reduced dose of the drug with minimized side effects. This review includes discussion of the delivery systems of 5-FU using biodegradable materials and some significant outcomes in the pre-clinical development of 5-fluorouracil carriers for the colon cancer.
authors.affiliation: Department of Internal Medicine, Lorestan University of Medical Sciences, Khoramabad, Iran.
authors.forename: Soleiman
authors.initials: S
authors.lastname: Jaferian
authors.affiliation: Department of Medical Biotechnology, School of Advance Science in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Babak
authors.initials: B
authors.lastname: Negahdari
authors.affiliation: Department of Medical Biotechnology, School of Advance Science in Medicine, Tehran University of Medical Sciences, Tehran, Iran; Department of Medical Biotechnology, School of Medicine, Lorestan University of Medical Sciences, Lorestan, Iran. Electronic address: a-eatemadi@razi.tums.ac.ir.
authors.forename: Ali
authors.initials: A
authors.lastname: Eatemadi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000378:metabolism; D001672:Biocompatible Materials / Q000008:administration & dosage* / Q000378:metabolism; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D016503:Drug Delivery Systems / Q000379:methods* / Q000639:trends; D005472:Fluorouracil / Q000008:administration & dosage* / Q000378:metabolism; D006801:Humans
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D005472:Fluorouracil
keywords: 5-FU; 5-Flurouracil; Colon cancer; Drug delivery; Polymer