title: Blepharochalasis: something to cry about.
abstract: Blepharochalasis is a rare disorder of unknown etiology defined by loose, atrophic periorbital skin following recurrent episodes of eyelid edema. Characteristic histopathology shows complete absence of elastic fibers. The current case progressed after multiple episodes of crying, which may be related to matrix metalloproteinase dysregulation. This case offers further insights into the possible pathogenesis of blepharochalasis, paving the way for more targeted, disease-modifying therapies.
authors.affiliation: Department of Dermatology, Medical College of Georgia at Georgia Regents University, Augusta, GA, USA.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Browning
authors.affiliation: Department of Dermatology, Medical College of Georgia at Georgia Regents University, Augusta, GA, USA.
authors.forename: April T
authors.initials: AT
authors.lastname: Sanchez
authors.affiliation: Clinical Pathology Laboratory Southeast, Augusta, GA, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Mullins
authors.affiliation: Department of Dermatology, Medical College of Georgia at Georgia Regents University, Augusta, GA, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Sheehan
authors.affiliation: Department of Dermatology, Medical College of Georgia at Georgia Regents University, Augusta, GA, USA.
authors.forename: Loretta S
authors.initials: LS
authors.lastname: Davis
mesh_terms: D003448:Crying; D004487:Edema / Q000209:etiology* / Q000473:pathology*; D005141:Eyelid Diseases / Q000209:etiology* / Q000473:pathology*; D005260:Female; D006801:Humans; D055815:Young Adult
keywords: MMP; blepharochalasis; crying; matrix metalloproteinase