title: The anti-cancer components ofGanoderma lucidumpossesses cardiovascular protective effect by regulating circular RNA expression.
abstract: To examine the role of oralGanodermaspore oil in cardiovascular disease, we used transverse aortic constriction (TAC) in mice to model pressure overload-induced cardiomyopathy. Our preliminary results demonstrated a potential cardioprotective role for spore oil extracted fromGanoderma. We found thatGanodermatreatment normalized ejection fraction and corrected the fractional shortening generated by TAC. We also found evidence of reduced left ventricular hypertrophy as assessed by left ventricular end diastolic diameter. Analysis of total RNA expression using cardiac tissue samples from these mice corroborated our findings. We found reduced expression of genes associated with heart failure, including a novel circular RNA circ-Foxo3. Thus our data provides evidence forGanoderma lucidumas a potential cardioprotective agent, warranting further preclinical exploration.
authors.affiliation: State Key Laboratory of Applied Microbiology Southern China, Guangdong Institute of Microbiology, Guangzhou, China.|Guangdong Yuewei Edible Fungi Technology Co. Ltd., Guangzhou, China.
authors.forename: Yi-Zhen
authors.initials: YZ
authors.lastname: Xie
authors.affiliation: Guangdong Laboratory Animals Monitoring Institute, Guangdong Provincial Key Laboratory of Laboratory Animals, Guangzhou, Guangdong, China.
authors.forename: Fenghua
authors.initials: F
authors.lastname: Yang
authors.affiliation: Guangdong Laboratory Animals Monitoring Institute, Guangdong Provincial Key Laboratory of Laboratory Animals, Guangzhou, Guangdong, China.
authors.forename: Weijiang
authors.initials: W
authors.lastname: Tan
authors.affiliation: State Key Laboratory of Applied Microbiology Southern China, Guangdong Institute of Microbiology, Guangzhou, China.|Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
authors.forename: Xiangmin
authors.initials: X
authors.lastname: Li
authors.affiliation: Guangdong Yuewei Edible Fungi Technology Co. Ltd., Guangzhou, China.
authors.forename: Chunwei
authors.initials: C
authors.lastname: Jiao
authors.affiliation: Guangdong Laboratory Animals Monitoring Institute, Guangdong Provincial Key Laboratory of Laboratory Animals, Guangzhou, Guangdong, China.
authors.forename: Ren
authors.initials: R
authors.lastname: Huang
authors.affiliation: Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.|Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
authors.forename: Burton B
authors.initials: BB
authors.lastname: Yang
keywords: Ganoderma lucidum; anti-cancer; circular RNA; heart function; herbal medicine