title: Adenosine Deaminase Activity in Chronic Lymphocytic Leukemia and Healthy Subjects.
abstract: BACKGROUND
  B cell chronic lymphocytic leukemia is one of the most frequent hematologic malignancies in the world. Cellular surface CD markers and serum Beta-2-microglobulin may be used as a prognostic tool in CLL patients.
  
  
  OBJECTIVE
  In the present study we introduce serum adenosine deaminase as a diagnostic marker in CLL.
  
  
  METHODS
  Blood samples were collected from B-CLL and healthy subjects. White blood cell, red blood cell and platelet count and blood Erythrocyte sedimentation rate was recorded and serum Beta-2-microglobulin, Lactate dehydrogenase and total ADA enzyme activity were determined.
  
  
  RESULTS
  Serum ADA activity was significantly higher in patients group than that of controls. ADA had a significant and direct correlation with B2M, WBC, LDH and ESR. However, there was not any relation between ADA and the stages of disease. Diagnostic cut-off, sensitivity and specificity of the serum ADA test were 27.97 U/L, 91% and 94%, respectively.
  
  
  CONCLUSIONS
  A higher ADA activity in patients group and its correlation with CLL markers were seen in our study. High diagnostic value of serum ADA in our study suggests that it might be considered as a useful screening tool among the other markers in CLL.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, IR Iran.
authors.forename: Bayazid
authors.initials: B
authors.lastname: Ghaderi
authors.affiliation: Department of Biology, College of Science, Islamic Azad University, Sanandaj, IR Iran.
authors.forename: Sabrieh
authors.initials: S
authors.lastname: Amini
authors.affiliation: Department of Biology, College of Science, Islamic Azad University, Sanandaj, IR Iran.
authors.forename: Farzad
authors.initials: F
authors.lastname: Maroofi
authors.affiliation: Department of Biology, College of Science, Islamic Azad University, Sanandaj, IR Iran.
authors.forename: Chiya
authors.initials: C
authors.lastname: Jalali
authors.affiliation: Department of Biology, College of Science, Islamic Azad University, Sanandaj, IR Iran.
authors.forename: Mitra
authors.initials: M
authors.lastname: Javanmardi
authors.affiliation: Department of Biology, College of Science, Islamic Azad University, Sanandaj, IR Iran.
authors.forename: Daem
authors.initials: D
authors.lastname: Roshani
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, IR Iran; Department of Biology, College of Science, Islamic Azad University, Sanandaj, IR Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Abdi
keywords: Adenosine Deaminase; Beta-2-Microglobulin; Chronic Lymphocytic Leukemia; Diagnostic Value