title: Recent progress on the discovery of antiamoebic agents.
abstract: A large number of protozoans infect humans but Entamoeba histolytica is the only organism responsible for causing amoebiasis, a deadly disease after malaria. Numerous heterocycle-based antiamoebic agents have been previously synthesized as E. histolytica inhibitors and while some of these agents have shown moderate activity, the search for a novel and ideal antiamoebic compound is still ongoing. In this digest Letter, we present the latest data on antiamoebic agents from 2011 to 2016 based on the different classes of heterocyclic agents.
authors.affiliation: College of Pharmacy, Gachon University, 191 Hambakmoe-ro, Yeonsu-gu, Incheon 21936, South Korea.
authors.forename: Faisal
authors.initials: F
authors.lastname: Hayat
authors.affiliation: Department of Chemistry, Jamia Millia Islamia (Central University), Jamia Nagar, New Delhi 110025, India.
authors.forename: Amir
authors.initials: A
authors.lastname: Azam
authors.affiliation: College of Pharmacy, Gachon University, 191 Hambakmoe-ro, Yeonsu-gu, Incheon 21936, South Korea. Electronic address: dyshin@gachon.ac.kr.
authors.forename: Dongyun
authors.initials: D
authors.lastname: Shin
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D002460:Cell Line; D055808:Drug Discovery; D004748:Entamoeba histolytica / Q000187:drug effects*; D006571:Heterocyclic Compounds / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50
chemical_list: D000981:Antiprotozoal Agents; D006571:Heterocyclic Compounds
keywords: Amoebiasis; Antiamoebic; Entamoeba histolytica; Inhibitor; Protozoan