title: Association of rs11643718 SLC12A3 and rs741301 ELMO1 Variants with Diabetic Nephropathy in South Indian Population.
abstract: This study reports on the association of genetic variants selected from previous genome-wide association studies for type 2 diabetic nephropathy in south Indians. Eight variants were genotyped in 601 type 2 diabetic subjects without nephropathy (DM) and 583 type 2 diabetic subjects with nephropathy (DN) by MassARRAY. The minor allele frequencies of rs11643718 SLC12A3 variant and rs741301 ELMO1 variant were significantly different between DM and DN groups (P = 0.029 and 0.016, respectively). A combined analysis showed that the subjects carrying the risk genotypes of both these variants (GG of rs11643718 + AG/AA of rs741301) had a significant association with DN with an odds ratio [adjusted for age, sex, Body Mass Index (BMI), HbA1c, and systolic Blood Pressure (BP)] of 1.73 (1.30-2.30, P = 1.72 × 10-4) as compared to subjects carrying all other genotype combinations. This is the first study to report a significant association of the SLC12A3 rs11643718 and ELMO1 rs741301 (Single nucleotide Polymorphism) SNPs with diabetic nephropathy in south Indians.
authors.affiliation: Department of Molecular Genetics, Madras Diabetes Research Foundation, Chennai, India.
authors.forename: Dhanasekaran
authors.initials: D
authors.lastname: Bodhini
authors.affiliation: Department of Molecular Genetics, Madras Diabetes Research Foundation, Chennai, India.
authors.forename: Manickam
authors.initials: M
authors.lastname: Chidambaram
authors.affiliation: Department of Molecular Genetics, Madras Diabetes Research Foundation, Chennai, India.
authors.forename: Samuel
authors.initials: S
authors.lastname: Liju
authors.affiliation: Department of Molecular Genetics, Madras Diabetes Research Foundation, Chennai, India.
authors.forename: Balakannan
authors.initials: B
authors.lastname: Revathi
authors.affiliation: Department of Molecular Genetics, Madras Diabetes Research Foundation, Chennai, India.
authors.forename: Dhandapani
authors.initials: D
authors.lastname: Laasya
authors.affiliation: Department of Molecular Genetics, Madras Diabetes Research Foundation, Chennai, India.
authors.forename: Natarajan
authors.initials: N
authors.lastname: Sathish
authors.affiliation: Department of Molecular Genetics, Madras Diabetes Research Foundation, Chennai, India.
authors.forename: Sekar
authors.initials: S
authors.lastname: Kanthimathi
authors.affiliation: Indian Statistical Institute, Kolkata, India.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Ghosh
authors.affiliation: Department of Molecular Genetics, Madras Diabetes Research Foundation, Chennai, India.|Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention & Control, IDF Centre of Education, Chennai, India.
authors.forename: Ranjit Mohan
authors.initials: RM
authors.lastname: Anjana
authors.affiliation: Department of Molecular Genetics, Madras Diabetes Research Foundation, Chennai, India.|Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention & Control, IDF Centre of Education, Chennai, India.
authors.forename: Viswanathan
authors.initials: V
authors.lastname: Mohan
authors.affiliation: Department of Molecular Genetics, Madras Diabetes Research Foundation, Chennai, India.
authors.forename: Venkatesan
authors.initials: V
authors.lastname: Radha
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000368:Aged; D044466:Asian People; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics*; D003928:Diabetic Nephropathies / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D064486:Solute Carrier Family 12, Member 3 / Q000235:genetics
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C465214:ELMO1 protein, human; C578874:SLC12A3 protein, human; D064486:Solute Carrier Family 12, Member 3
keywords: Diabetic nephropathy; ELMO1 gene; SLC12A3 gene; South Indians; rs11643718; rs741301