title: Prognostic outlier genes for enhanced prostate cancer treatment.
abstract: OBJECTIVE
  To review the current landscape of outlier genes in the field of prostate cancer.
  
  
  METHODS
  A comprehensive review was performed.
  
  
  RESULTS
  Prostate cancer continues to be a significant worldwide health issue. In the era of personalized medicine, more emphasis is being placed on the ability to determine the timing, intensity and type of treatment, according to each patient's unique disease. Several commercial tests are available to determine the risk of aggressive prostate cancer based on genomic biomarkers and gene expression. Outlier genes represent a form of cancer classification that focuses on bimodal expression of a gene in a specific subset of patients. Outlier genes identified in prostate cancer include TMPRSS2-ERG, SPINK1, ScHLAP1, NVL, SMC4 and SQLE.
  
  
  CONCLUSIONS
  Classifying patient prostate cancers by outlier genes may allow for individualized cancer therapies and improved cancer therapy outcomes.
authors.affiliation: Department of Radiation Oncology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107, USA.
authors.forename: Hyun
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Radiation Oncology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107, USA.
authors.forename: Jenna
authors.initials: J
authors.lastname: Skowronski
authors.affiliation: Department of Radiation Oncology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107, USA.
authors.forename: Robert B
authors.initials: RB
authors.lastname: Den
mesh_terms: D003131:Combined Modality Therapy; D019295:Computational Biology / Q000379:methods; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D056726:Genetic Association Studies; D005820:Genetic Testing; D023281:Genomics / Q000379:methods; D006801:Humans; D008297:Male; D057285:Precision Medicine; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality / Q000628:therapy*; D016896:Treatment Outcome
keywords: biomarkers; biomarkers/oncogenes/molecular; oncology; urologic/prostate