title: Visualizing the Architectures and Interactions of Nuclear Receptors.
abstract: Nuclear receptors (NRs) are master regulators of broad genetic programs in metazoans. These programs are regulated in part by the small-molecule ligands that bind NRs and modulate their interactions with transcriptional coregulatory factors. X-ray crystallography is now delivering more complete pictures of how the multidomain architectures of NR homo- and heterodimers are physically arranged on their DNA elements and how ligands and coactivator peptides act through these complexes. Complementary studies are also pointing to a variety of novel mechanisms by which NRs access their DNA-response elements within chromatin. Here, we review the new structural advances together with proteomic discoveries that shape our understanding of how NRs form a variety of functional interactions with collaborating factors in chromatin.
authors.affiliation: Integrative Metabolism Program, SBP Medical Discovery Institute, Orlando, Florida 32827.
authors.forename: Sepideh
authors.initials: S
authors.lastname: Khorasanizadeh
authors.affiliation: Integrative Metabolism Program, SBP Medical Discovery Institute, Orlando, Florida 32827.
authors.forename: Fraydoon
authors.initials: F
authors.lastname: Rastinejad
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism; D018360:Crystallography, X-Ray; D004247:DNA / Q000378:metabolism; D006801:Humans; D040901:Proteomics; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D002843:Chromatin; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D004247:DNA