title: Red blood cell exchange: 2015 American Society for Apheresis consensus conference on the management of patients with sickle cell disease.
abstract: The American Society for Apheresis (ASFA) conducted a one-day consensus conference on red blood cell exchange (RBCx) in sickle cell disease (SCD) during its annual meeting in San Antonio, TX, on May 5, 2015. The authors of this article, a subcommittee of ASFA's Clinical Applications Committee, developed several questions with regard to pathophysiology of SCD and use of RBCx in the management of various complications. These questions were provided to the seven invited speakers who are the experts in the field of SCD. Two experts in the field moderated the proceedings of the conference, which was attended by more than 150 participants. After each presentation, there was a summary of the main points by the moderators and an open discussion with questions from the audience. A video recording of the proceedings, as well as each presentation, was made available to the authors. Each author's summary was reviewed and approved by the respective speaker before submission of this manuscript. The subcommittee also developed several key questions to generate a consensus amongst the speakers on key issues for using RBCx for patients with SCD.
authors.affiliation: Department of Pathology, Division of Transfusion Medicine and Hemostasis, UT Southwestern Medical Center, Dallas, Texas.
authors.forename: Ravi
authors.initials: R
authors.lastname: Sarode
authors.affiliation: Department of Medicine, Cardeza Foundation for Hematologic Research, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.
authors.forename: Samir K
authors.initials: SK
authors.lastname: Ballas
authors.affiliation: Children's Hospital & Research Center, Oakland, California.
authors.forename: Alicia
authors.initials: A
authors.lastname: Garcia
authors.affiliation: Departments of Pediatrics and Pathology, Children's Hospital of Philadelphia, Perelman School of Medicine University of Pennsylvania, Philadelphia, PA.
authors.forename: Haewon C
authors.initials: HC
authors.lastname: Kim
authors.affiliation: Department of Pathology, Transfusion Medicine, Johns Hopkins University, Baltimore, Maryland.
authors.forename: Karen
authors.initials: K
authors.lastname: King
authors.affiliation: New York Blood Center, New York, New York.
authors.forename: Bruce
authors.initials: B
authors.lastname: Sachais
authors.affiliation: Department of Pathology, Division of Laboratory Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
authors.forename: Lance A
authors.initials: LA
authors.lastname: Williams
mesh_terms: D056586:Acute Chest Syndrome / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D000743:Anemia, Hemolytic / Q000209:etiology; D000755:Anemia, Sickle Cell / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D001781:Blood Component Removal / Q000009:adverse effects / Q000379:methods*; D017707:Erythrocyte Transfusion / Q000009:adverse effects / Q000379:methods*; D006461:Hemolysis; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology; D012955:Societies, Medical; D020521:Stroke / Q000517:prevention & control; D014481:United States
keywords: acute chest syndrome; pulmonary hypertension; red blood cell exchange; sickle cell disease; stroke