title: Successful management of acute interstitial nephritis in two cases of disseminated tuberculosis.
abstract: Acute interstitial nephritis (AIN) is characterized by an inflammatory infiltrate in the kidney interstitium and a decline in the creatinine clearance. Medications used for the treatment of tuberculosis have been implicated in the development of AIN, but there is limited data on how to manage AIN in this setting and which medications and dosages should be used to treat tuberculosis once AIN occurs. We describe two cases of AIN in the setting of disseminated tuberculosis in which AIN was successfully managed. It is recommended that Infectious Diseases and Nephrology be involved early in the care of these patients, preferably in an inpatient setting in order to expedite diagnosis and management.
authors.affiliation: Texas Center for Infectious Disease, Internal Medicine, University of Texas Northeast, University of Texas Health Science Center, San Antonio, USA.
authors.forename: Quratulain
authors.initials: Q
authors.lastname: Kizilbash
mesh_terms: D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D057915:Drug Substitution; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis / Q000628:therapy*; D016896:Treatment Outcome; D014391:Tuberculosis, Miliary / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D015415:Biomarkers; D003404:Creatinine
keywords: Acute interstitial nephritis; Diagnosis; Management; Tuberculosis