title: Serum osteopontin is a biomarker of severe fibrosis and portal hypertension in human and murine schistosomiasis mansoni.
abstract: Schistosomiasis is a major cause of fibrosis and portal hypertension. The reason 4-10% of infected subjects develops hepatosplenic schistosomiasis remains unclear. Chronically infected male CBA/J mice reproduce the dichotomic forms of human schistosomiasis. Most mice (80%) develop moderate splenomegaly syndrome (similar to hepatointestinal disease in humans) and 20% present severe hypersplenomegaly syndrome (analogous to human hepatosplenic disease). We demonstrated that the profibrogenic molecule osteopontin discriminates between mice with severe and mild disease and could be a novel morbidity biomarker in murine and human schistosomiasis. Failure to downregulate osteopontin during the chronic phase may explain why hepatosplenic subjects develop severe fibrosis.
authors.affiliation: Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC, USA; Departamento de Clínica Médica, Laboratório de Doenças Infecciosas e Parasitárias, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil; Immunopathogesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Thiago Almeida
authors.initials: TA
authors.lastname: Pereira
authors.affiliation: Liver Regeneration and Repair Research Group, Institute of Hepatology, Foundation for Liver Research, London, UK; Division of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, SC, USA; Section of Gastroenterology, Ralph H Johnson Veteran Affairs Medical Center, Charleston, SC, USA.
authors.forename: Wing-Kin
authors.initials: WK
authors.lastname: Syn
authors.affiliation: Núcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitória, ES, Brazil.
authors.forename: Fausto E L
authors.initials: FE
authors.lastname: Pereira
authors.affiliation: Departamento de Clínica Médica, Laboratório de Doenças Infecciosas e Parasitárias, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: José Roberto
authors.initials: JR
authors.lastname: Lambertucci
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: William Evan
authors.initials: WE
authors.lastname: Secor
authors.affiliation: Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC, USA. Electronic address: diehl004@mc.duke.edu.
authors.forename: Anna Mae
authors.initials: AM
authors.lastname: Diehl
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D015415:Biomarkers / Q000097:blood; D004195:Disease Models, Animal; D005355:Fibrosis / Q000097:blood / Q000175:diagnosis / Q000469:parasitology; D006801:Humans; D006975:Hypertension, Portal / Q000097:blood / Q000175:diagnosis* / Q000469:parasitology; D007411:Intestinal Diseases, Parasitic / Q000097:blood / Q000175:diagnosis* / Q000469:parasitology; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis* / Q000469:parasitology; D008137:Longitudinal Studies; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D053495:Osteopontin / Q000097:blood*; D012372:ROC Curve; D012555:Schistosomiasis mansoni / Q000150:complications*; D013163:Splenomegaly / Q000175:diagnosis* / Q000469:parasitology
chemical_list: D015415:Biomarkers; D053495:Osteopontin
keywords: Biomarker; Liver fibrosis; Osteopontin; Portal hypertension; Schistosomiasis mansoni