title: Angioedema After Squaric Acid Treatment in a 6-Year-Old Girl.
abstract: Alopecia areata (AA) involves the immune-related destruction of hair follicles, resulting in patches of complete hair loss, most often on the scalp. The topical sensitizer squaric acid dibutylester (SADBE) is a popular treatment option given its low side-effect profile, hair regrowth potential, and lack of cross-reactivity with other chemicals. We describe a unique case of a 6-year-old girl who developed angioedema after SADBE treatment for AA.
authors.affiliation: Harvard Medical School, Boston, Massachusetts.
authors.forename: Chen Amy
authors.initials: CA
authors.lastname: Chen
authors.affiliation: Harvard Medical School, Boston, Massachusetts.|Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: Valerie
authors.initials: V
authors.lastname: Carlberg
authors.affiliation: Harvard Medical School, Boston, Massachusetts.|Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: Daniela
authors.initials: D
authors.lastname: Kroshinsky
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000009:adverse effects*; D000485:Allergens / Q000009:adverse effects*; D000506:Alopecia Areata / Q000188:drug therapy; D000799:Angioedema / Q000139:chemically induced*; D002648:Child; D003503:Cyclobutanes / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans
chemical_list: D000276:Adjuvants, Immunologic; D000485:Allergens; D003503:Cyclobutanes; C020637:squaric acid dibutyl ester