title: The effect of structurally related impurities on crystallinity reduction of sulfamethazine by grinding.
abstract: In this study, the effect of structurally related impurities on crystallinity reduction of sulfamethazine by grinding was evaluated. The crystallinity of sulfamethazine was not decreased when it was ground alone. However, when structurally related impurities with sulfonamide derivatives were blended, the crystallinity of sulfamethazine was decreased by grinding. Other materials without a sulfonamide moiety showed no such effect. The Raman spectra of sulfamethazine demonstrated that there was a difference between its crystalline and amorphous states within its sulfonamide structure. It was suggested that the sulfonamide structure of the impurities was important in causing the inhibition of recrystallization of sulfamethazine during grinding.
authors.affiliation: Analytical and Quality Evaluation Research Laboratories, Daiichi Sankyo Co. Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan; Graduate School of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan. Electronic address: hamada.yoshito.tc@daiichisankyo.co.jp.
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Hamada
authors.affiliation: Analytical and Quality Evaluation Research Laboratories, Daiichi Sankyo Co. Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Ono
authors.affiliation: Analytical and Quality Evaluation Research Laboratories, Daiichi Sankyo Co. Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
authors.forename: Motomu
authors.initials: M
authors.lastname: Ohara
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan.
authors.forename: Etsuo
authors.initials: E
authors.lastname: Yonemochi
mesh_terms: D003460:Crystallization / Q000379:methods; D004339:Drug Compounding / Q000379:methods; D013059:Spectrum Analysis, Raman / Q000379:methods; D013418:Sulfamethazine / Q000737:chemistry*
chemical_list: D013418:Sulfamethazine
keywords: Crystallinity reduction; Effect of impurity; Grinding; Raman spectroscopy; Sulfamethazine