title: CE-MS for metabolomics: Developments and applications in the period 2014-2016.
abstract: CE-MS can be considered a useful analytical technique for the global profiling of (highly) polar and charged metabolites in various samples. Over the past few years, significant advancements have been made in CE-MS approaches for metabolomics studies. In this paper, which is a follow-up of a previous review paper covering the years 2012-2014 (Electrophoresis 2015, 36, 212-224), recent CE-MS strategies developed for metabolomics covering the literature from July 2014 to June 2016 are outlined. Attention will be paid to new CE-MS approaches for the profiling of anionic metabolites and the potential of SPE coupled to CE-MS is also demonstrated. Representative examples illustrate the applicability of CE-MS in the fields of biomedical, clinical, microbial, plant, and food metabolomics. A complete overview of recent CE-MS-based metabolomics studies is given in a table, which provides information on sample type and pretreatment, capillary coatings, and MS detection mode. Finally, general conclusions and perspectives are given.
authors.affiliation: Division of Analytical Biosciences, LACDR, Leiden University, Leiden, The Netherlands.
authors.forename: Rawi
authors.initials: R
authors.lastname: Ramautar
authors.affiliation: Division of BioAnalytical Chemistry, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
authors.forename: Govert W
authors.initials: GW
authors.lastname: Somsen
authors.affiliation: Biomolecular Analysis, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
authors.forename: Gerhardus J
authors.initials: GJ
authors.lastname: de Jong
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis; D019075:Electrophoresis, Capillary / Q000379:methods*; D005504:Food Analysis; D006801:Humans; D057625:Isotachophoresis / Q000379:methods*; D013058:Mass Spectrometry / Q000379:methods*; D055432:Metabolomics / Q000379:methods*; D009711:Nucleotides / Q000032:analysis; D009930:Organic Chemicals / Q000032:analysis; D010944:Plants / Q000737:chemistry; D013403:Sugar Phosphates / Q000032:analysis; D013499:Surface Properties
chemical_list: D015415:Biomarkers; D009711:Nucleotides; D009930:Organic Chemicals; D013403:Sugar Phosphates
keywords: Biomedical and clinical; Food; Metabolomics; Microbial and plant; Technological developments