title: Easy on-demand single-pass self-assembly and modification to fabricate gold@graphene-based anti-inflammatory nanoplatforms.
abstract: Zwitterionic chitosan (ZC) was modified by fully (both for lateral dimension and thickness) nanodimensional gold-graphene oxide (Au@GO) flakes under visible light and the potential of the resulting materials as biomedical nanoplatforms was investigated. Fully nanodimensional GO flakes floating in nitrogen gas were incorporated with Au nanoparticles to form Au@GO nanoflakes, and the Au@GO was then incorporated with ZC droplets to form the Au@GO-ZC hybrid nanoparticles. The collected particles were exposed to visible light to induce the photocatalytic activity of the Au@GO nanoflakes towards the ZC derivatives. The visible-light-exposed particles show different chemical and surface properties from the unexposed particles, while there were no significant differences in cytotoxicity and macrophage inflammatory protein production. This work suggests that incorporating fully nanodimensional Au@GO flakes with ZC is a suitable technique for ambient photo-modification of the chitosans' surface property without significant changes in size and shape and increases in cytotoxicity and inflammatory response.
authors.affiliation: School of Mechanical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea.
authors.forename: Jeong Hoon
authors.initials: JH
authors.lastname: Byeon
authors.affiliation: School of Health Sciences, Purdue University, IN 47907, United States.
authors.forename: Jae Hong
authors.initials: JH
authors.lastname: Park
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D020346:Aquaporins / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan; D005136:Eye Proteins / Q000378:metabolism; D006046:Gold / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008027:Light; D008070:Lipopolysaccharides / Q000633:toxicity; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D036103:Nanotechnology / Q000379:methods*; D010316:Particle Size; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
chemical_list: D000893:Anti-Inflammatory Agents; D020346:Aquaporins; D005136:Eye Proteins; D008070:Lipopolysaccharides; C030328:aquaporin 0; D006046:Gold; D006108:Graphite; D048271:Chitosan