title: Association of GSTO2 (N142D) Genetic Polymorphism and Acute Rejection of Liver.
abstract: BACKGROUND
  Acute rejection is the main problem in liver transplantation that occurs in the first days or months of transplantation. It includes histological and cellular rejection. Acute histological rejection is confirmed by biopsy. Glutathione S-transferase family is the most important genes in phase II detoxification working in xenobiotic and drug metabolism. GSTO2is one of the members of this family. GSTO2(N142D) polymorphism may influence metabolism of immunosuppressive drugs.
  
  
  OBJECTIVE
  To determine ifGSTO2polymorphism has association with acute liver rejection.
  
  
  METHODS
  The present study included 120 patients with histological-proven acute liver rejection and 182 patients without acute rejection. Both groups were matched for sex and age. To determine variants ofGSTO2,we used polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
  
  
  RESULTS
  There was a significant association between theGSTO2genotype and acute liver rejection (NN: OR: 3.642, 95% CI: 1.179-5.444) and (ND: OR: 2.533, 95% CI: 1.672-8.149) compared to those with DD geneotype.
  
  
  CONCLUSIONS
  Recipients with either NN or ND genotype forGSTO2are more likely to develop acute liver rejection compared to those with DD genotype.
authors.affiliation: Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Khosravi
authors.affiliation: Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran.
authors.forename: I
authors.initials: I
authors.lastname: Saadat
authors.affiliation: Transplant Research Center, Shiraz University of Medical Sciences, Namazi Hospital, Shiraz, Iran.
authors.forename: M H
authors.initials: MH
authors.lastname: Karimi
authors.affiliation: Transplant Research Center, Shiraz University of Medical Sciences, Namazi Hospital, Shiraz, Iran.
authors.forename: S A
authors.initials: SA
authors.lastname: Malek Hosseini
keywords: Glutathione S-Transferase; Graft rejection; Metabolic Detoxication; Phase II; Polymorphism; genetic; transplantation