title: Prospective longitudinal course of cognition in older subjects with mild parkinsonian signs.
abstract: Mild parkinsonian signs (MPS) are common in older people and are associated with an increased risk of different neurodegenerative diseases. This study prospectively evaluates the longitudinal course of cognitive performance in older individuals with MPS.
  
  
  
  From the TREND study, 480 individuals neurologically healthy at baseline, aged between 50 and 80 years, with complete follow-up data for three assessments within a mean of 43.8 months, were included in this analysis. Participants underwent a detailed cognitive test battery, evaluation of prodromal markers for neurodegenerative diseases and history of vascular diseases at each study visit. In addition, plasma levels of amyloid-beta (Aβ)1-40and Aβ1-42were evaluated longitudinally.
  
  
  
  In 52 (11 %) of the 480 participants, MPS could be detected at baseline. These individuals had cognitive deficits significantly more often compared with controls at each time point and their cognitive performance showed a steeper decline during follow-up. In addition, their levels of plasma Aβ1-42were significantly lower than those of controls, and declined more rapidly over time.
  
  
  
  This longitudinal study shows that MPS are associated with cognitive decline and decrease in plasma Aβ1-42, possibly indicating an ongoing neurodegenerative process.
authors.affiliation: Center of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Hoppe Seyler-Strasse 3, Tuebingen, 72076, Germany. Stefanie.lerche@uni-tuebingen.de.|German Center for Neurodegenerative Diseases, University of Tuebingen, Otfried-Müller-Straße 27, Tuebingen, 72076, Germany. Stefanie.lerche@uni-tuebingen.de.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Lerche
authors.affiliation: Center of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Hoppe Seyler-Strasse 3, Tuebingen, 72076, Germany.|German Center for Neurodegenerative Diseases, University of Tuebingen, Otfried-Müller-Straße 27, Tuebingen, 72076, Germany.
authors.forename: Kathrin
authors.initials: K
authors.lastname: Brockmann
authors.affiliation: Center of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Hoppe Seyler-Strasse 3, Tuebingen, 72076, Germany.|Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Pilotto
authors.affiliation: Center of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Hoppe Seyler-Strasse 3, Tuebingen, 72076, Germany.|German Center for Neurodegenerative Diseases, University of Tuebingen, Otfried-Müller-Straße 27, Tuebingen, 72076, Germany.
authors.forename: Isabel
authors.initials: I
authors.lastname: Wurster
authors.affiliation: Center of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Hoppe Seyler-Strasse 3, Tuebingen, 72076, Germany.|German Center for Neurodegenerative Diseases, University of Tuebingen, Otfried-Müller-Straße 27, Tuebingen, 72076, Germany.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Sünkel
authors.affiliation: Center of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Hoppe Seyler-Strasse 3, Tuebingen, 72076, Germany.|German Center for Neurodegenerative Diseases, University of Tuebingen, Otfried-Müller-Straße 27, Tuebingen, 72076, Germany.
authors.forename: Markus A
authors.initials: MA
authors.lastname: Hobert
authors.affiliation: Center of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Hoppe Seyler-Strasse 3, Tuebingen, 72076, Germany.|German Center for Neurodegenerative Diseases, University of Tuebingen, Otfried-Müller-Straße 27, Tuebingen, 72076, Germany.
authors.forename: Anna-Katharina
authors.initials: AK
authors.lastname: von Thaler
authors.affiliation: Center of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Hoppe Seyler-Strasse 3, Tuebingen, 72076, Germany.|German Center for Neurodegenerative Diseases, University of Tuebingen, Otfried-Müller-Straße 27, Tuebingen, 72076, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Schulte
authors.affiliation: ADx NeuroSciences, Gent, 9052, Belgium.
authors.forename: Erik
authors.initials: E
authors.lastname: Stoops
authors.affiliation: ADx NeuroSciences, Gent, 9052, Belgium.
authors.forename: Hugo
authors.initials: H
authors.lastname: Vanderstichele
authors.affiliation: EUROIMMUN Medizinische Labordiagnostika AG, Lübeck, Germany.
authors.forename: Victor
authors.initials: V
authors.lastname: Herbst
authors.affiliation: EUROIMMUN Medizinische Labordiagnostika AG, Lübeck, Germany.
authors.forename: Britta
authors.initials: B
authors.lastname: Brix
authors.affiliation: Geriatric Center at the University Hospital of Tübingen, Tübingen, Germany.|Department of Psychiatry and Psychotherapy, University Hospital of Tübingen, Tübingen, Germany.
authors.forename: Gerhard W
authors.initials: GW
authors.lastname: Eschweiler
authors.affiliation: Geriatric Center at the University Hospital of Tübingen, Tübingen, Germany.|Department of Psychiatry and Psychotherapy, University Hospital of Tübingen, Tübingen, Germany.
authors.forename: Florian G
authors.initials: FG
authors.lastname: Metzger
authors.affiliation: Center of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Hoppe Seyler-Strasse 3, Tuebingen, 72076, Germany.|German Center for Neurodegenerative Diseases, University of Tuebingen, Otfried-Müller-Straße 27, Tuebingen, 72076, Germany.
authors.forename: Walter
authors.initials: W
authors.lastname: Maetzler
authors.affiliation: Center of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Hoppe Seyler-Strasse 3, Tuebingen, 72076, Germany.|German Center for Neurodegenerative Diseases, University of Tuebingen, Otfried-Müller-Straße 27, Tuebingen, 72076, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Berg
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000097:blood; D001057:Apolipoproteins E / Q000235:genetics; D059168:Carotid Intima-Media Thickness; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology*; D003863:Depression / Q000209:etiology; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D015835:Ocular Motility Disorders / Q000209:etiology; D000857:Olfaction Disorders / Q000175:diagnosis / Q000209:etiology; D020734:Parkinsonian Disorders / Q000097:blood / Q000150:complications* / Q000235:genetics; D012895:Sleep, REM / Q000502:physiology
chemical_list: D016229:Amyloid beta-Peptides; D001057:Apolipoproteins E
keywords: Amyloid-beta; Cohort study; Dementia; Longitudinal; Prospective