title: Self-assembled high-strength hydroxyapatite/graphene oxide/chitosan composite hydrogel for bone tissue engineering.
abstract: Graphene hydrogel has shown greatly potentials in bone tissue engineering recently, but it is relatively weak in the practical use. Here we report a facile method to synthesize high strength composite graphene hydrogel. Graphene oxide (GO), hydroxyapatite (HA) nanoparticles (NPs) and chitosan (CS) self-assemble into a 3-dimensional hydrogel with the assistance of crosslinking agent genipin (GNP) for CS and reducing agent sodium ascorbate (NaVC) for GO simultaneously. The dense and oriented microstructure of the resulted composite gel endows it with high mechanical strength, high fixing capacity of HA and high porosity. These properties together with the good biocompatibility make the ternary composite gel a promising material for bone tissue engineering. Such a simultaneous crosslinking and reduction strategy can also be applied to produce a variety of 3D graphene-polymer based nanocomposites for biomaterials, energy storage materials and adsorbent materials.
authors.affiliation: College of Polymer Science and Engineering, Sichuan University, State Key Laboratory of Polymer Materials Engineering, Chengdu, 610065 Sichuan, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Yu
authors.affiliation: College of Polymer Science and Engineering, Sichuan University, State Key Laboratory of Polymer Materials Engineering, Chengdu, 610065 Sichuan, China.
authors.forename: Rui-Ying
authors.initials: RY
authors.lastname: Bao
authors.affiliation: Department of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan, China. Electronic address: shixj83@163.com.
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Shi
authors.affiliation: College of Polymer Science and Engineering, Sichuan University, State Key Laboratory of Polymer Materials Engineering, Chengdu, 610065 Sichuan, China. Electronic address: weiyang@scu.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
authors.affiliation: College of Polymer Science and Engineering, Sichuan University, State Key Laboratory of Polymer Materials Engineering, Chengdu, 610065 Sichuan, China.
authors.forename: Ming-Bo
authors.initials: MB
authors.lastname: Yang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001854:Bone Marrow Cells; D001861:Bone Regeneration; D002478:Cells, Cultured; D048271:Chitosan / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D006108:Graphite; D020100:Hydrogels; D010087:Oxides; D011817:Rabbits; D013234:Stem Cells; D023822:Tissue Engineering; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels; D010087:Oxides; D006108:Graphite; D048271:Chitosan; D017886:Durapatite
keywords: Bone tissue engineering; Chitosan; Composite hydrogel; Graphene oxide; Hydroxyapatite