title: The effect of n-3 LCPUFA supplementation on oxidative stress and inflammation in the placenta and maternal plasma during pregnancy.
abstract: Pregnancy represents a state of heightened oxidative stress and inflammation, and these processes are further increased in pregnancy complications. The quality of the maternal diet is directly associated with maternal health and wellbeing, pregnancy and fetal outcomes, as well as the risk of pregnancy complications. Long chain polyunsaturated fatty acids (LCPUFAs) have significant potential to modify placental and fetal lipid environments and thereby modulate health outcomes. The omega-3 (n-3) LCPUFA in particular have been shown to exhibit both antioxidant and anti-inflammatory properties, and have potential therapeutic applications in reducing oxidative damage and inflammation during pregnancy. The purpose of this review is to provide an overview of our current understanding of the impact of maternal n-3 LCPUFA supplementation on oxidative stress and inflammation during pregnancy, with a particular focus on effects on the mother and the placenta.
authors.affiliation: FOODplus Research Centre, School of Agriculture, Food and Wine, The University of Adelaide, Waite Campus, Urrbrae, South Australia 5064, Australia.
authors.forename: G E
authors.initials: GE
authors.lastname: Leghi
authors.affiliation: FOODplus Research Centre, School of Agriculture, Food and Wine, The University of Adelaide, Waite Campus, Urrbrae, South Australia 5064, Australia; Women's and Children's Health Research Institute, Women's and Children's Hospital, Adelaide, Australia. Electronic address: beverly.muhlhausler@adelaide.edu.au.
authors.forename: B S
authors.initials: BS
authors.lastname: Muhlhausler
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000494:pharmacology; D019587:Dietary Supplements; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D006801:Humans; D039382:Maternal Nutritional Physiological Phenomena; D018384:Oxidative Stress / Q000187:drug effects*; D010920:Placenta / Q000187:drug effects* / Q000276:immunology; D010949:Plasma / Q000187:drug effects / Q000276:immunology; D011247:Pregnancy
chemical_list: D000893:Anti-Inflammatory Agents; D015525:Fatty Acids, Omega-3
keywords: Inflammation; Nutrition; Omega-3 fatty acids; Oxidative stress; Placenta; Pregnancy