title: Intestinal microbiota in adult patients with Short Bowel Syndrome: Preliminary results from a pilot study.
abstract: Intestinal bacterial flora plays a central role in human intestinal health and disease. Short Bowel Syndrome (SBS), a clinical condition deriving from extensive bowel resections, influence intestinal microbiota (IM) composition in order to reach a new metabolic balance. Little is known about IM in adult patients after wide intestinal resections.
  
  
  
  Fecal samples from 12 SBS patients and 16 controls were analyzed in their microbial profile by using both culture-dependent method and quantitative Real-Time PCR (qRT-PCR).
  
  
  
  The two methods revealed significant lower concentrations of Bacteroidetes (p-value = .02), Firmicutes (p-value = .05), Bifidobacterium (p-value < .01), and Methanobrevibacter Smithii (p-value = .04) in SBS patients than controls.
  
  
  
  The significantly different fecal microbiome in SBS patients compared with healthy controls could open new perspectives on the care of their intestinal functions.
authors.affiliation: Section of Hygiene - Institute of Public Health, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario "Agostino Gemelli", L.go F. Vito, 1, 00168 Rome, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Boccia
authors.affiliation: Department of Public Health, University of Naples "Federico II", Naples, Italy.
authors.forename: Ida
authors.initials: I
authors.lastname: Torre
authors.affiliation: Internal Medicine and Clinical Nutrition Unit, Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy. Electronic address: lidia.santarpia@unina.it.
authors.forename: Lidia
authors.initials: L
authors.lastname: Santarpia
authors.affiliation: Department of Public Health, University of Naples "Federico II", Naples, Italy.
authors.forename: Carmela
authors.initials: C
authors.lastname: Iervolino
authors.affiliation: Internal Medicine and Clinical Nutrition Unit, Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.
authors.forename: Concetta
authors.initials: C
authors.lastname: Del Piano
authors.affiliation: Section of Hygiene - Institute of Public Health, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario "Agostino Gemelli", L.go F. Vito, 1, 00168 Rome, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Puggina
authors.affiliation: Section of Hygiene - Institute of Public Health, Università Cattolica del Sacro Cuore, L.go F. Vito, 1, 00168 Rome, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Pastorino
authors.affiliation: Section of Hygiene - Institute of Public Health, Università Cattolica del Sacro Cuore, L.go F. Vito, 1, 00168 Rome, Italy.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Dragic
authors.affiliation: Section of Hygiene - Institute of Public Health, Università Cattolica del Sacro Cuore, L.go F. Vito, 1, 00168 Rome, Italy.
authors.forename: Rosarita
authors.initials: R
authors.lastname: Amore
authors.affiliation: Department of Public Health, University of Naples "Federico II", Naples, Italy.
authors.forename: Tonia
authors.initials: T
authors.lastname: Borriello
authors.affiliation: Department of Public Health, University of Naples "Federico II", Naples, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Palladino
authors.affiliation: Department of Public Health, University of Naples "Federico II", Naples, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Pennino
authors.affiliation: Internal Medicine and Clinical Nutrition Unit, Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Contaldo
authors.affiliation: Internal Medicine and Clinical Nutrition Unit, Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Pasanisi
mesh_terms: D000328:Adult; D000368:Aged; D001644:Bifidobacterium / Q000302:isolation & purification; D016022:Case-Control Studies; D005243:Feces / Q000382:microbiology; D005260:Female; D000068536:Bacillota / Q000302:isolation & purification; D000069196:Gastrointestinal Microbiome; D006801:Humans; D007422:Intestines / Q000382:microbiology; D007778:Lactobacillus / Q000302:isolation & purification; D008297:Male; D041581:Methanobrevibacter / Q000302:isolation & purification; D008875:Middle Aged; D010865:Pilot Projects; D012778:Short Bowel Syndrome / Q000382:microbiology* / Q000628:therapy; D055815:Young Adult
keywords: Intestinal microbiota; Short Bowel Syndrome