title: PIWI Takes a Giant Step.
abstract: piRNA guides the action of PIWI proteins to silence deleterious transposons in animal reproductive tissues. Biogenesis of piRNA-induced silencing complex (piRISC) involves a multi-step process. In this issue, Matsumoto et al. report the first crystal structure of a PIWI-clade protein displaying a guide RNA, ready for action.
authors.affiliation: Department of Molecular Biology and Genetics, Cornell University, 251 Biotechnology Building, Ithaca, NY 14853, USA.
authors.forename: Yibei
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: Department of Molecular Biology and Genetics, Cornell University, 251 Biotechnology Building, Ithaca, NY 14853, USA. Electronic address: ailong.ke@cornell.edu.
authors.forename: Ailong
authors.initials: A
authors.lastname: Ke
mesh_terms: D000818:Animals; D060565:Argonaute Proteins / Q000235:genetics*; D004251:DNA Transposable Elements; D029721:Drosophila Proteins / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics; D034741:RNA, Small Interfering / Q000235:genetics
chemical_list: D060565:Argonaute Proteins; D004251:DNA Transposable Elements; D029721:Drosophila Proteins; D034741:RNA, Small Interfering