title: Jasmine rice panicle: A safe and efficient natural ingredient for skin aging treatments.
abstract: BACKGROUND
  While rice is one of the most important global staple food sources its extracts have found many uses as the bases of herbal remedies. Rice extracts contain high levels of phenolic compounds which are known to be bioactive, some of which show cutaneous benefits and activity towards skin disorders. This study highlights an assessment of the cellular activity and clinical efficacy of rice panicle extract, providing necessary information relevant to the development of new cosmetic products.
  
  
  METHODS
  Jasmine rice panicle extract was standardized, and the level of phenolics present was determined. In vitro anti-aging, and extract activity towards melanogenesis was conducted in B16F10 melanoma cells, and antioxidant activity was assessed in human skin fibroblast cell cultures. Topical product creams containing the extract were developed, and skin irritation testing using a single application closed patch test method was done using 20 Thai volunteers. Randomized double-blind, placebo-controlled efficacy evaluation was undertaken in 24 volunteers over an 84d period, with the results monitored by Corneometer®CM 825, Cutometer®MPA 580, Mexameter®MX 18 and Visioscan®VC 98.
  
  
  RESULTS
  Jasmine rice panicle extract was shown to have a high content of p-coumaric, ferulic and caffeic acids, and was not cytotoxic to the cell lines used in this study. Cells treated with extract suppressed melanogenesis via tyrosinase and TRP-2 inhibitory effects, which protect the cell from oxidative stress at doses of 0.1mg/ml or lower. The jasmine rice panicle preparations (0.1-0.2%) were safe (MII=0), and significantly (p<0.05) increased skin hydration levels relative to baseline. Skin lightening, and anti-wrinkle effects related to skin firmness and smoothness were observed, in addition to a reduction in skin wrinkling. Improvements in skin biophysics of both 0.1% and 0.2% extracts were showed to be comparable (p>0.05).
  
  
  CONCLUSIONS
  Jasmine rice panicle extract having high levels of phenolics shows cutaneous benefits as the basis for skin aging treatments, as indicated through in vitro cytotoxicity assessments and skin testing in human subjects.
authors.affiliation: School of Cosmetic Science, Mae Fah Luang University, Chiang Rai, 57100 Thailand; Phytocosmetics and Cosmeceuticals Research Group, Mae Fah Luang University, Chiang Rai 57100, Thailand. Electronic address: mayuree@mfu.ac.th.
authors.forename: Mayuree
authors.initials: M
authors.lastname: Kanlayavattanakul
authors.affiliation: School of Cosmetic Science, Mae Fah Luang University, Chiang Rai, 57100 Thailand; Phytocosmetics and Cosmeceuticals Research Group, Mae Fah Luang University, Chiang Rai 57100, Thailand.
authors.forename: Nattaya
authors.initials: N
authors.lastname: Lourith
authors.affiliation: School of Cosmetic Science, Mae Fah Luang University, Chiang Rai, 57100 Thailand; Phytocosmetics and Cosmeceuticals Research Group, Mae Fah Luang University, Chiang Rai 57100, Thailand.
authors.forename: Puxvadee
authors.initials: P
authors.lastname: Chaikul
mesh_terms: D000328:Adult; D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004311:Double-Blind Method; D004355:Drug Stability; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D064368:Healthy Volunteers; D006801:Humans; D056626:Inflorescence / Q000737:chemistry*; D008543:Melanins / Q000378:metabolism; D008544:Melanocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008875:Middle Aged; D012275:Oryza / Q000737:chemistry*; D010328:Patch Tests; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D015595:Skin Aging / Q000187:drug effects*; D023422:Skin Irritancy Tests; D055815:Young Adult
chemical_list: D000975:Antioxidants; D008543:Melanins; D010936:Plant Extracts
keywords: Cellular activities; Clinical trials; In vitro activities; Jasmine rice panicle; Skin aging