title: Evaluation of the microscopic dose enhancement for nanoparticle-enhanced Auger therapy.
abstract: The aim of this study is to investigate the dosimetric characteristics of nanoparticle-enhanced Auger therapy. Monte Carlo (MC) simulations were performed to assess electron energy spectra and dose enhancement distributions around a nanoparticle. In the simulations, two types of nanoparticle structures were considered: nanoshell and nanosphere, both of which were assumed to be made of one of five elements (Fe, Ag, Gd, Au, and Pt) in various sizes (2-100 nm). Auger-electron emitting radionuclides (I-125, In-111, and Tc-99m) were simulated within a nanoshell or on the surface of a nanosphere. For the most promising combination of Au and I-125, the maximum dose enhancement was up to 1.3 and 3.6 for the nanoshell and the nanosphere, respectively. The dose enhancement regions were restricted within 20-100 nm and 0-30 nm distances from the surface of Au nanoshell and nanosphere, respectively. The dose enhancement distributions varied with sizes of nanoparticles, nano-elements, and radionuclides and thus should be carefully taken into account for biological modeling. If the nanoparticles are accumulated in close proximity to the biological target, this new type of treatment can deliver an enhanced microscopic dose to the target (e.g. DNA). Therefore, we conclude that Auger therapy combined with nanoparticles could have the potential to provide a better therapeutic effect than conventional Auger therapy alone.
authors.affiliation: Department of Transdisciplinary Studies, Program in Biomedical Radiation Sciences, Seoul National University Graduate School of Convergence Science and Technology, Seoul, Korea. Biomedical Research Institute, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Wonmo
authors.initials: W
authors.lastname: Sung
authors.forename: Seongmoon
authors.initials: S
authors.lastname: Jung
authors.forename: Sung-Joon
authors.initials: SJ
authors.lastname: Ye
mesh_terms: D003198:Computer Simulation; D004247:DNA / Q000737:chemistry*; D004307:Dose-Response Relationship, Radiation; D004583:Electrons; D006801:Humans; D008954:Models, Biological; D009010:Monte Carlo Method; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D011868:Radioisotopes / Q000627:therapeutic use*; D011874:Radiometry
chemical_list: D011868:Radioisotopes; D004247:DNA