title: Prognostic impact of serum soluble LR11 in newly diagnosed diffuse large B-cell lymphoma: A multicenter prospective analysis.
abstract: BACKGROUND
  LR11 (also called SorLA or SORL1) is a type I membrane protein, originally identified as a biomarker for atherosclerosis and Alzheimer's disease. We recently found that LR11 was specifically expressed in Diffuse Large B-cell lymphoma (DLBCL) cells, and high serum sLR11 concentrations in retrospective cohort indicated inferior survival. In this study, we prospectively validated the clinical impact of serum sLR11 in 97 patients with newly-diagnosed, untreated DLBCL.
  
  
  RESULTS
  Serum sLR11 concentrations were increased in DLBCL patients compared to normal controls (mean±SD: 21.2±27.6 vs. 8.8±1.8ng/ml, P<0.0001), and significantly reduced at remission (mean±SD: 17.4±16.4 vs. 10.9±4.5ng/ml, P=0.02). Increased serum sLR11 concentrations were affected by tumor burden and bone marrow invasion. The 2-y OS and PFS were significantly lower in patients with high sLR11 concentrations (≤18.1ng/ml vs. >18.1ng/ml; 2-y OS: 89.0% vs. 56.4%, P<0.0001; 2-y PFS: 85.8% vs. 56.9%, P<0.0001).
  
  
  CONCLUSIONS
  Serum sLR11 is a tumor-derived biomarker for predicting the survival of newly diagnosed patients with DLBCL.
authors.affiliation: Department of Hematology, Chiba University Hospital, 1-8-1 Chuo-ku, Chiba City, Chiba, Japan.
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Sugita
authors.affiliation: Department of Hematology, Chiba University Hospital, 1-8-1 Chuo-ku, Chiba City, Chiba, Japan. Electronic address: chikako_ohwada@faculty.chiba-u.jp.
authors.forename: Chikako
authors.initials: C
authors.lastname: Ohwada
authors.affiliation: Department of Hematology, Oami Municipal Hospital, 884-1 Tomita, Oamishirasato City, Chiba, Japan.
authors.forename: Takeharu
authors.initials: T
authors.lastname: Kawaguchi
authors.affiliation: Department of Hematology, Chiba University Hospital, 1-8-1 Chuo-ku, Chiba City, Chiba, Japan.
authors.forename: Tomoya
authors.initials: T
authors.lastname: Muto
authors.affiliation: Department of Hematology, Chiba University Hospital, 1-8-1 Chuo-ku, Chiba City, Chiba, Japan.
authors.forename: Shokichi
authors.initials: S
authors.lastname: Tsukamoto
authors.affiliation: Department of Hematology, Chiba University Hospital, 1-8-1 Chuo-ku, Chiba City, Chiba, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Takeda
authors.affiliation: Department of Transfusion Medicine and Cell Therapy, Chiba University Hospital, 1-8-1 Chuo-ku, Chiba City, Chiba, Japan.
authors.forename: Naoya
authors.initials: N
authors.lastname: Mimura
authors.affiliation: Department of Hematology, Chiba University Hospital, 1-8-1 Chuo-ku, Chiba City, Chiba, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Takeuchi
authors.affiliation: Department of Hematology, Chiba University Hospital, 1-8-1 Chuo-ku, Chiba City, Chiba, Japan.
authors.forename: Emiko
authors.initials: E
authors.lastname: Sakaida
authors.affiliation: Department of Blood Transfusion, Toho University Medical Center Sakura Hospital, 564-1 Shimoshizu, Sakura City, Chiba, Japan.
authors.forename: Naomi
authors.initials: N
authors.lastname: Shimizu
authors.affiliation: Department of Hematology, Oami Municipal Hospital, 884-1 Tomita, Oamishirasato City, Chiba, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Tanaka
authors.affiliation: Department of Hematology, Yokohama Rousai Hospital, 3211 Kozukue-cho, Kohoku-ku, Yokohama City, Kanagawa, Japan.
authors.forename: Daijiro
authors.initials: D
authors.lastname: Abe
authors.affiliation: Department of Hematology, Funabashi Central Hospital, 6-13-10 Kaijin, Funabashi City, Chiba, Japan.
authors.forename: Motoharu
authors.initials: M
authors.lastname: Fukazawa
authors.affiliation: Department of Hematology Oncology, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba City, Chiba, Japan.
authors.forename: Takeaki
authors.initials: T
authors.lastname: Sugawara
authors.affiliation: Department of Hematology, Japanese Red Cross Narita Hospital, 90-1 Iida-cho, Narita City, Chiba, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Aotsuka
authors.affiliation: Clinical Oncology and Hematology, Jikei University Kashiwa Hospital, 163-1 Kashiwashita, Kashiwa City, Chiba, Japan.
authors.forename: Kaichi
authors.initials: K
authors.lastname: Nishiwaki
authors.affiliation: Department of Hematology, Chiba Aoba Municipal Hospital, 1273-2 Aoba-cho, Chuo-ku, Chiba City, Chiba, Japan.
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Shono
authors.affiliation: Tsukuba Research Institute, Sekisui Medical Co. Ltd, 3-3-1 Koyodai, Ryugasaki City, Ibaraki, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ebinuma
authors.affiliation: Tsukuba Research Institute, Sekisui Medical Co. Ltd, 3-3-1 Koyodai, Ryugasaki City, Ibaraki, Japan.
authors.forename: Kengo
authors.initials: K
authors.lastname: Fujimura
authors.affiliation: Department of Clinical Laboratory Medicine, Toho University Medical Center Sakura Hospital, 564-1 Shimoshizu, Sakura City, Chiba, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Bujo
authors.affiliation: Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, 1-8-1, Chuo-ku, Chiba City, Chiba, Japan.
authors.forename: Koutaro
authors.initials: K
authors.lastname: Yokote
authors.affiliation: Department of Hematology, Chiba University Hospital, 1-8-1 Chuo-ku, Chiba City, Chiba, Japan.
authors.forename: Chiaki
authors.initials: C
authors.lastname: Nakaseko
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood / Q000737:chemistry; D001853:Bone Marrow / Q000473:pathology; D005260:Female; D006801:Humans; D026502:LDL-Receptor Related Proteins / Q000097:blood* / Q000737:chemistry*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000097:blood* / Q000175:diagnosis*; D008297:Male; D026901:Membrane Transport Proteins / Q000097:blood* / Q000737:chemistry*; D008875:Middle Aged; D015203:Reproducibility of Results; D012995:Solubility; D016019:Survival Analysis; D047368:Tumor Burden; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D026502:LDL-Receptor Related Proteins; D026901:Membrane Transport Proteins; C102582:SORL1 protein, human
keywords: Bone marrow invasion; Circulating molecule; Diffuse large B-cell lymphoma; Overall survival; Progression-free survival; Tumor burden