title: Acquired FVIII and FIX Inhibitors after Pregnancy: A Case Report.
abstract: Acquired hemophilia is a relatively rare clinical presentation, and most cases present with acquired FVIII inhibitor. The co-occurrence of inhibitors to multiple coagulation factors is uncommon. These autoantibodies may induce spontaneous life-threatening bleeding in patients who have had no previous bleeding disorder. Herein, we present a patient with postpartum acquired FVIII and FIX inhibitors who developed intramuscular hematoma and hemothorax during follow-up. She was then treated with activated prothrombin complex concentrate and methylprednisolone.
authors.affiliation: Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Kose
authors.forename: Oguz Kagan
authors.initials: OK
authors.lastname: Bakkaloglu
authors.forename: Shirkhan
authors.initials: S
authors.lastname: Amikishiyev
authors.forename: Timur Selcuk
authors.initials: TS
authors.lastname: Akpınar
authors.forename: Basak
authors.initials: B
authors.lastname: Saracoglu
authors.forename: Tugce
authors.initials: T
authors.lastname: Akcan
authors.forename: Melike
authors.initials: M
authors.lastname: Oktem
authors.forename: Mustafa Nuri
authors.initials: MN
authors.lastname: Yenerel
authors.forename: Kerim
authors.initials: K
authors.lastname: Güler
authors.forename: Tufan
authors.initials: T
authors.lastname: Tükek
mesh_terms: D001323:Autoantibodies / Q000097:blood; D005169:Factor VIII / Q000276:immunology*; D005260:Female; D006406:Hematoma; D006467:Hemophilia A / Q000097:blood*; D006470:Hemorrhage; D006801:Humans; D011247:Pregnancy
chemical_list: D001323:Autoantibodies; D005169:Factor VIII