title: Cytogenetics in the management of multiple myeloma: an update by the Groupe francophone de cytogénétique hématologique (GFCH).
abstract: Cytogenetics of multiple myeloma has evolved in recent years by the emergence of Interphasic fluorescence in situ hybridization (FISH) performed on sorted plasma cells detecting abnormalities independently of a proliferative and infiltrative index. Cytogenetic analysis plays a major part in the risk stratification of myeloma diagnosis due to prognostic impact of various cytogenetic abnormalities as well as to the association between emerging therapeutic approaches in MM. Thus, practice guidelines now recommend interphasic FISH or alternative molecular technics as the initial analysis for multiple myeloma. The Groupe francophone de cytogénétique hématologique (GFCH) proposes in this issue an update of managing multiple myeloma cytogenetics.
authors.affiliation: UF de cytogénétique hématologique, Pôle biologie-hygiène, Valenciennes, France.
authors.forename: Agnès
authors.initials: A
authors.lastname: Daudignon
authors.affiliation: Service de cytogénétique, Laboratoire Biomnis, Lyon, France.
authors.forename: Benoît
authors.initials: B
authors.lastname: Quilichini
authors.affiliation: Centre de génétique humaine, Cliniques universitaires St-Luc-Université catholique de Louvain, Bruxelles, Belgique.
authors.forename: Geneviève
authors.initials: G
authors.lastname: Ameye
authors.affiliation: Centre de génétique humaine, Cliniques universitaires St-Luc & de Duve Institute-Université catholique de Louvain, Bruxelles, Belgique.
authors.forename: Hélène
authors.initials: H
authors.lastname: Poirel
authors.affiliation: Département de génétique, Centre Henri Becquerel, Rouen, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Bastard
authors.affiliation: Laboratoire de cytogénétique, Centre de transfusion sanguine, Le Chesnay, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Terré
mesh_terms: D020732:Cytogenetic Analysis / Q000379:methods / Q000592:standards*; D005602:France; D006405:Hematology / Q000458:organization & administration / Q000592:standards / Q000639:trends; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D009101:Multiple Myeloma / Q000175:diagnosis / Q000235:genetics / Q000628:therapy*; D012955:Societies, Medical / Q000458:organization & administration / Q000592:standards
keywords: FISH; cytogenetic; myeloma; plasma cells sorted