title: Recent trends on hydrogel based drug delivery systems for infectious diseases.
abstract: Since centuries, the rapid spread and cure of infectious diseases have been a major concern to the progress and survival of humans. These diseases are a global burden and the prominent cause for worldwide deaths and disabilities. Nanomedicine has emerged as the most excellent tool to eradicate and halt their spread. Various nanoformulations (NFs) using advanced nanotechnology are in demand. Recently, hydrogel and nanogel based drug delivery devices have posed new prospects to simulate the natural intelligence of various biological systems. Owing to their unique porous interpenetrating network design, hydrophobic drug incorporation and stimulus sensitivity hydrogels owe excellent potential as targeted drug delivery systems. The present review is an attempt to highlight the recent trends of hydrogel based drug delivery systems for the delivery of therapeutic agents and diagnostics for major infectious diseases including acquired immune deficiency syndrome (AIDS), malaria, tuberculosis, influenza and ebola. Future prospects and challenges are also described.
authors.affiliation: Center of Personalized Nanomedicine, Institute of Neuroimmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL-33199, USA. avashist@fiu.edu nairm@fiu.edu.
authors.forename: Arti
authors.initials: A
authors.lastname: Vashist
authors.affiliation: Center of Personalized Nanomedicine, Institute of Neuroimmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL-33199, USA. avashist@fiu.edu nairm@fiu.edu.
authors.forename: Ajeet
authors.initials: A
authors.lastname: Kaushik
authors.affiliation: Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, 110029, India.
authors.forename: Atul
authors.initials: A
authors.lastname: Vashist
authors.affiliation: Center of Personalized Nanomedicine, Institute of Neuroimmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL-33199, USA. avashist@fiu.edu nairm@fiu.edu.
authors.forename: Rahul Dev
authors.initials: RD
authors.lastname: Jayant
authors.affiliation: Center of Personalized Nanomedicine, Institute of Neuroimmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL-33199, USA. avashist@fiu.edu nairm@fiu.edu.
authors.forename: Asahi
authors.initials: A
authors.lastname: Tomitaka
authors.affiliation: Materials Research Laboratory, Department of Chemistry, New Delhi, 110025, India.
authors.forename: Sharif
authors.initials: S
authors.lastname: Ahmad
authors.affiliation: Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, 110029, India.
authors.forename: Y K
authors.initials: YK
authors.lastname: Gupta
authors.affiliation: Center of Personalized Nanomedicine, Institute of Neuroimmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL-33199, USA. avashist@fiu.edu nairm@fiu.edu.
authors.forename: Madhavan
authors.initials: M
authors.lastname: Nair
mesh_terms: D003141:Communicable Diseases / Q000188:drug therapy*; D016503:Drug Delivery Systems / Q000639:trends*; D006801:Humans; D020100:Hydrogels; D050997:Nanomedicine / Q000639:trends; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D020100:Hydrogels