title: Coordination of Two Genomes by Mitochondrial Translational Plasticity.
abstract: The dual genetic origin of mitochondrial respiratory chain complexes leads to the synthesis of subunits by mitochondrial and cytosolic ribosomes. Now, Richter-Dennerlein et al. report that membrane-integrated assembly factors associate with ribosome nascent chain complexes in human mitochondria to coordinate translational plasticity with the import of subunits from the cytosol.
authors.affiliation: Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany. Electronic address: heike.rampelt@biochemie.uni-freiburg.de.
authors.forename: Heike
authors.initials: H
authors.lastname: Rampelt
authors.affiliation: Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany; BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany. Electronic address: nikolaus.pfanner@biochemie.uni-freiburg.de.
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Pfanner
mesh_terms: D003600:Cytosol / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000235:genetics; D014176:Protein Biosynthesis; D012270:Ribosomes / Q000378:metabolism*