title: Synthesis, spectral analysis and biological evaluation of Nalkyl/aralkyl/aryl-4-chlorobenzenesulfonamide derivatives.
abstract: New potent organic compounds were synthesized with an aim of good biological activities such as antibacterial and anti-enzymatic. Three series of sulfonamide derivatives were synthesized by treating N-alkyl/aryl substituted amines (2a-f) with 4-chlorobenzensulfonyl chloride (1) to yield N-alkyl/aryl-4-chlorobenzenesulfonamide(3af) that was then derivatized by gearing up with ethyl iodide (4), benzyl chloride (5) and 4-chlorobenzyl chloride (6) using sodium hydride as base to initialize the reaction in a polar aprotic solvent (DMF) to synthesize the derivatives, 7a-f, 8af and 9a-f respectively. Structure elucidation was brought about by IR, 1H-NMR and EIMS spectra for all the synthesized molecules which were evaluated for their antibacterial activities and inhibitory potentials for certain enzymes.
authors.affiliation: Department of Chemistry, Government College University, Lahore, Pakistan.
authors.forename: Azizur
authors.initials: A
authors.lastname: Rehman
authors.affiliation: Department of Chemistry, Government College University, Lahore, Pakistan.
authors.forename: Muhammad Athar
authors.initials: MA
authors.lastname: Abbasi
authors.affiliation: Department of Chemistry, Government College University, Lahore, Pakistan.
authors.forename: Sabahat Zahra
authors.initials: SZ
authors.lastname: Siddiqui
authors.affiliation: Department of Chemistry, School of Science and Technology, University of Management & Technology, Lahore, Pakistan.
authors.forename: Ayesha
authors.initials: A
authors.lastname: Mohyuddin
authors.affiliation: Department of Chemistry, School of Science and Technology, University of Management & Technology, Lahore, Pakistan.
authors.forename: Sohail
authors.initials: S
authors.lastname: Nadeem
authors.affiliation: Atta-ur-Rahman Institute for Natural Products Discovery (AuRIns), Level 9, FF3, University Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia / Faculty of Pharmacy, University Technology MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia.
authors.forename: Syed Adnan
authors.initials: SA
authors.lastname: Shah
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development; D002918:Chymotrypsin / Q000037:antagonists & inhibitors; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D016859:Lipoxygenase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D013058:Mass Spectrometry; D015394:Molecular Structure; D066244:Proton Magnetic Resonance Spectroscopy; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology*; D000096926:Benzenesulfonamides
chemical_list: D000900:Anti-Bacterial Agents; D002918:Chymotrypsin; D004791:Enzyme Inhibitors; D016859:Lipoxygenase Inhibitors; D015842:Serine Proteinase Inhibitors; D013449:Sulfonamides; C047440:4-chlorobenzenesulfonamide; D000096926:Benzenesulfonamides; C117608:alpha-chymotrypsin