title: A practical metal-free homolytic aromatic alkylation protocol for the synthesis of 3-(pyrazin-2-yl)bicyclo[1.1.1]pentane-1-carboxylic acid.
abstract: As a part of our ongoing synthetic quest to expand the frontiers of contemporary medicinal chemistry, we now report an expedient synthesis of a potentially useful bicyclo[1.1.1]pentane building block, 3-(pyrazin-2-yl)bicyclo[1.1.1]pentane-1-carboxylic acid. This report also showcases the application of this motif as a probe in a biological study.
authors.affiliation: Institute of Chemical and Engineering Sciences (ICES), Agency for Science technology and Research (A*STAR), 8 Biomedical Grove, Neuros, #07-01, Singapore 138665, Singapore. vikrant_adsool@ices.a-star.edu.sg.
authors.forename: Navanita T
authors.initials: NT
authors.lastname: Thirumoorthi
authors.affiliation: Institute of Chemical and Engineering Sciences (ICES), Agency for Science technology and Research (A*STAR), 8 Biomedical Grove, Neuros, #07-01, Singapore 138665, Singapore. vikrant_adsool@ices.a-star.edu.sg.
authors.forename: Vikrant A
authors.initials: VA
authors.lastname: Adsool