title: Severe Acute Subdural Hemorrhages in a Patient with Glutaric Acidemia Type 1 under Recommended Treatment.
abstract: Glutaric acidemia type 1 is a rare autosomal recessive disease caused by a deficiency of glutaryl-CoA dehydrogenase. Previous studies have reported subdural hemorrhage in untreated patients with glutaric acidemia type 1. However, there is only one report of severe acute subdural hemorrhage after minor head trauma in a patient with glutaric acidemia type 1 under guideline-recommended treatment. We report a second case of life-threatening severe acute subdural hemorrhage after a minor head trauma in a patient with glutaric acidemia type 1. This patient was previously diagnosed by newborn screening, and treatment began at 25 days of age. Early diagnosis and guideline-recommended treatment produce better outcomes for patients with glutaric acidemia type 1, although the risk of subdural hemorrhage remains.
authors.affiliation: Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Mika
authors.initials: M
authors.lastname: Ishige
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Fuchigami
authors.forename: Erika
authors.initials: E
authors.lastname: Ogawa
authors.forename: Hiromi
authors.initials: H
authors.lastname: Usui
authors.forename: Ryutaro
authors.initials: R
authors.lastname: Kohira
authors.forename: Yoriko
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Shori
authors.initials: S
authors.lastname: Takahashi
mesh_terms: D000592:Amino Acid Metabolism, Inborn Errors / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D001928:Brain Diseases, Metabolic / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D006259:Craniocerebral Trauma / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D050770:Glutaryl-CoA Dehydrogenase / Q000172:deficiency*; D020199:Hematoma, Subdural, Acute / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D007223:Infant; D008297:Male; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D050770:Glutaryl-CoA Dehydrogenase