title: Developing a Clinically Representative Model of Periprosthetic Joint Infection.
abstract: ➤The poor treatment outcomes for periprosthetic joint infection (PJI) reflect the limited understanding that currently exists regarding the pathogenesis of this devastating clinical problem.➤Current animal models of PJI are limited in their translational nature primarily because of their inability to recreate the periprosthetic environment.➤A greater mechanistic understanding of the musculoskeletal and immune systems of small animals, such as mice and rats, provides a more robust platform for modeling and examining the pathogenesis of PJI.➤A clinically representative PJI model must involve an implant that recreates the periprosthetic space and be amenable to methodologies that identify implant biofilm as well as quantify the peri-implant bacterial load.
authors.affiliation: Hospital for Special Surgery, New York, NY CarliA@hss.edu.
authors.forename: Alberto V
authors.initials: AV
authors.lastname: Carli
authors.affiliation: Hospital for Special Surgery, New York, NY RossF@hss.edu.
authors.forename: F Patrick
authors.initials: FP
authors.lastname: Ross
authors.affiliation: Hospital for Special Surgery, New York, NY BhimaniS@hss.edu.
authors.forename: Samrath J
authors.initials: SJ
authors.lastname: Bhimani
authors.affiliation: Hospital for Special Surgery, New York, NY NodzoS@hss.edu.
authors.forename: Scott R
authors.initials: SR
authors.lastname: Nodzo
authors.affiliation: Hospital for Special Surgery, New York, NY BostromM@hss.edu.
authors.forename: Mathias P G
authors.initials: MP
authors.lastname: Bostrom
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D016459:Prosthesis-Related Infections / Q000601:surgery*; D011817:Rabbits