title: Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation.
abstract: A novel class of detergents, designated tandem neopentyl glycol maltosides (TNMs), were evaluated with four target membrane proteins. The best detergent varied depending on the target, but TNM-C12L and TNM-C11S were notable for their ability to confer increased membrane protein stability compared to DDM. These agents have potential for use in membrane protein research.
authors.affiliation: Department of Bionanotechnology, Hanyang University, Ansan, 15588, Korea. pchae@hanyang.ac.kr.
authors.forename: Hyoung Eun
authors.initials: HE
authors.lastname: Bae
authors.affiliation: Department of Neuroscience and Pharmacology, University of Copenhagen, DK-2200 Copenhagen, Denmark. cllo@sund.ku.dk.
authors.forename: Jonas S
authors.initials: JS
authors.lastname: Mortensen
authors.affiliation: Department of Life Sciences, Imperial College London, London, SW7 2AZ, UK. b.byrne@imperial.ac.uk.
authors.forename: Orquidea
authors.initials: O
authors.lastname: Ribeiro
authors.affiliation: Molecular and Cellular Physiology, Stanford, CA 94305, USA. kobilka@stanford.edu.
authors.forename: Yang
authors.initials: Y
authors.lastname: Du
authors.affiliation: Department of Bionanotechnology, Hanyang University, Ansan, 15588, Korea. pchae@hanyang.ac.kr.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ehsan
authors.affiliation: Molecular and Cellular Physiology, Stanford, CA 94305, USA. kobilka@stanford.edu.
authors.forename: Brian K
authors.initials: BK
authors.lastname: Kobilka
authors.affiliation: Department of Neuroscience and Pharmacology, University of Copenhagen, DK-2200 Copenhagen, Denmark. cllo@sund.ku.dk.
authors.forename: Claus J
authors.initials: CJ
authors.lastname: Loland
authors.affiliation: Department of Life Sciences, Imperial College London, London, SW7 2AZ, UK. b.byrne@imperial.ac.uk.
authors.forename: Bernadette
authors.initials: B
authors.lastname: Byrne
authors.affiliation: Department of Bionanotechnology, Hanyang University, Ansan, 15588, Korea. pchae@hanyang.ac.kr.
authors.forename: Pil Seok
authors.initials: PS
authors.lastname: Chae
mesh_terms: D003902:Detergents / Q000737:chemistry* / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology*; D008320:Maltose / Q000737:chemistry*; D008565:Membrane Proteins / Q000737:chemistry*; D055550:Protein Stability / Q000187:drug effects
chemical_list: D003902:Detergents; D006027:Glycosides; D008565:Membrane Proteins; D008320:Maltose