title: Effects of exercise on Irisin, BDNF and IL-6 serum levels in patients with progressive multiple sclerosis.
abstract: Clinical studies have suggested beneficial effects of exercise on cognitive function in ageing adults and neurodegenerative diseases such as dementia. Recent work indicates the same for progressive multiple sclerosis (MS), an inflammatory and degenerative disease of the central nervous system (CNS). The biological pathways associated with these effects are however not well understood.
  
  
  
  In this randomized controlled study, we explored serum levels of the myokine Irisin, the neurotrophin brain-derived neurotrophic factor (BDNF) and Interleukin-6 (IL-6) during acute endurance exercise and over the course of a 9-weeks endurance exercise training period in n=42 patients with progressive MS.
  
  
  
  We detected a significant increase of BDNF levels in progressive MS patients after 30min of bicycling (p<0.001). However, there were no significant changes for baseline levels after 22 sessions of training. No significant effects of acute or prolonged exercise could be found for Irisin or Interleukin-6.
  
  
  
  Our results indicate that BDNF is strongly induced during acute exercise even in patients with progressive MS and advanced physical disability. Long-term effects of exercise programs on biological parameters (Irisin, BDNF, IL-6) were much less pronounced. Given the hypothesis-driven selection of a limited set of biological markers in this pilot study, future studies should use unbiased approaches in larger samples to obtain a comprehensive picture of the networks involved in exercise effects on neurological diseases.
authors.affiliation: Institute of Neuroimmunology and Multiple Sclerosis (INIMS), Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Psychiatry, Psychotherapy and Psychosomatics, Vivantes Klinikum am Urban and Vivantes Klinikum im Friedrichshain, Academic Hospital Charite Medicine, Berlin, Germany.
authors.forename: Sven
authors.initials: S
authors.lastname: Briken
authors.affiliation: Institute of Neuroimmunology and Multiple Sclerosis (INIMS), Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: Sina Cathérine
authors.initials: SC
authors.lastname: Rosenkranz
authors.affiliation: Fraunhofer IME ScreeningPort, Hamburg, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Keminer
authors.affiliation: Competence Center for Sports and Exercise Medicine (Athleticum), University Hospital Eppendorf, Hamburg, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Patra
authors.affiliation: Department of Physiotherapy, University Medical Center Hamburg-Eppendorf, Germany.
authors.forename: Gesche
authors.initials: G
authors.lastname: Ketels
authors.affiliation: Institute of Neuroimmunology and Multiple Sclerosis (INIMS), Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Heesen
authors.affiliation: Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Charité Universitätsmedizin, Berlin.
authors.forename: Rainer
authors.initials: R
authors.lastname: Hellweg
authors.affiliation: Fraunhofer IME ScreeningPort, Hamburg, Germany.
authors.forename: Ole
authors.initials: O
authors.lastname: Pless
authors.affiliation: Competence Center for Sports and Exercise Medicine (Athleticum), University Hospital Eppendorf, Hamburg, Germany; Institute for Medical Psychology, University Medical Center Hamburg-Eppendorf, Germany.
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: Schulz
authors.affiliation: Institute of Neuroimmunology and Multiple Sclerosis (INIMS), Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin, Charité Universitätsmedizin, Berlin, Germany. Electronic address: stefan.gold@charite.de.
authors.forename: Stefan M
authors.initials: SM
authors.lastname: Gold
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D015331:Cohort Studies; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test / Q000379:methods; D005260:Female; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000628:therapy*; D010865:Pilot Projects
chemical_list: D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; C577593:FNDC5 protein, human; D005353:Fibronectins; C508600:IL6 protein, human; D015850:Interleukin-6; C579455:BDNF protein, human
keywords: Aerobic exercise; Cytokines; Inflammation; Metabolism; Multiple sclerosis; Neurotrophic factors; Randomized controlled trial; Rehabilitation