title: Beyond the aorta: partial transmission of reflected waves from aortic coarctation into supra-aortic branches modulates cerebral hemodynamics and left ventricular load.
abstract: Wave reflection from the site of aortic coarctation produces a reflected backward compression wave (BCW) that raises left ventricular (LV) afterload. However, not all reflected wave power will propagate back to the LV. This study investigated the hypothesis that the BCW is partially transmitted into supra-aortic vessels as a forward wave and explored the consequences of this phenomenon for cerebral and LV haemodynamic load. In eight sheep, high fidelity pressure and flow were measured in the aortic trunk (AoT) and brachiocephalic trunk (BCT, the single supra-aortic vessel present in sheep) at baseline and during two levels of proximal descending aortic constriction. Wave power analysis showed that aortic constriction produced not only a BCW in the AoT, but also a second forward compression wave ([Formula: see text] in the BCT that augmented pressure and flow after the initial forward compression wave ([Formula: see text]. Mathematical analysis and a one-dimensional model of the human systemic arteries and aortic coarctation suggested that the relative transmission of waves into supra-aortic vessels versus the aorta was determined by the relative admittances of these vessels. Reducing supra-aortic admittance (1) increased pressure and flow pulsatility in cerebral arteries, (2) produced carotid and middle cerebral arterial flow waveforms with an older adult phenotype, (3) promoted transmission of reflected wave power towards the LV and (4) substantially increased mid- to late-systolic myocardial stress, which may promote LV hypertrophy. These findings suggest that wave transmission into supra-aortic branches has an important impact on both cerebral hemodynamics and LV load in aortic coarctation.
authors.affiliation: Heart Research, Clinical Sciences, Murdoch Childrens Research Institute, 50 Flemington Road, Parkville, VIC, 3052, Australia. jonathan.mynard@mcri.edu.au.|Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia. jonathan.mynard@mcri.edu.au.
authors.forename: Jonathan P
authors.identifier: 0000-0002-5692-2106
authors.initials: JP
authors.lastname: Mynard
authors.affiliation: Heart Research, Clinical Sciences, Murdoch Childrens Research Institute, 50 Flemington Road, Parkville, VIC, 3052, Australia.|Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia.|Department of Cardiology, Royal Children's Hospital, Parkville, VIC, Australia.
authors.forename: Remi
authors.initials: R
authors.lastname: Kowalski
authors.affiliation: Heart Research, Clinical Sciences, Murdoch Childrens Research Institute, 50 Flemington Road, Parkville, VIC, 3052, Australia.|Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia.|Department of Cardiology, Royal Children's Hospital, Parkville, VIC, Australia.
authors.forename: Michael M H
authors.initials: MM
authors.lastname: Cheung
authors.affiliation: Heart Research, Clinical Sciences, Murdoch Childrens Research Institute, 50 Flemington Road, Parkville, VIC, 3052, Australia.|Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia.
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Smolich
mesh_terms: D000818:Animals; D001011:Aorta / Q000502:physiology; D001017:Aortic Coarctation / Q000503:physiopathology*; D006352:Heart Ventricles / Q000503:physiopathology; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D012756:Sheep
keywords: Carotid artery; Cerebral artery; Left ventricular afterload; Myocardial stress; Wave intensity; Wave power; Wave reflection