title: Total synthesis and related studies of large, strained, and bioactive natural products.
abstract: Our chemical syntheses and related scientific investigations of natural products with complex architectures and powerful biological activities are described, focusing on the very large 3 nm-long polycyclic ethers called the ciguatoxins, highly strained and labile chromoprotein antitumor antibiotics featuring nine-membered enediyne cores, and extremely potent anthelmintic macrolides called the avermectins.
authors.affiliation: Department of Chemistry, Graduate School of Science, Tohoku University.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hirama
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002922:Ciguatoxins / Q000737:chemistry; D008968:Molecular Conformation; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D001688:Biological Products; D002922:Ciguatoxins