title: Effects of NSAIDs on Differentiation and Function of Human and Murine Osteoclasts - Crucial 'Human Osteoclastology'.
abstract: Osteoclasts play a critical role in both normal bone metabolism and bone resorption in the joints of patients with rheumatoid arthritis. It has been reported that non-steroidal anti-inflammatory drugs (NSAIDs) inhibit murine osteoclastogenesisin vitroand murine arthritis modelsin vivo, but not the destruction of joints of patients with rheumatoid arthritis. In the current review article, we review the recent findings in the effect of NSAIDs on the formation and function of human and murine osteoclasts bothin vitroandin vivo, underlining the importance of studies using human osteoclasts. Since 2009, we have suggested a novel term 'human osteoclastology'.
authors.affiliation: Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo 162-0054, Japan. skotake@ior.twmu.ac.jp.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kotake
authors.affiliation: Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo 162-0054, Japan. toruyago@yahoo.co.jp.
authors.forename: Toru
authors.initials: T
authors.lastname: Yago
authors.affiliation: Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo 162-0054, Japan. kawamoto@ior.twmu.ac.jp.
authors.forename: Manabu
authors.initials: M
authors.lastname: Kawamoto
authors.affiliation: Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo 162-0054, Japan. ynn@ior.twmu.ac.jp.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Nanke
keywords: interleukin-17 (IL-17); non-steroidal anti-inflammatory drugs (NSAIDs); osteo-clastogenesis; osteoclast; osteoclastology; prostaglandin E2 (PGE2)