title: One year in review 2016: pathogenesis of rheumatoid arthritis.
abstract: Rheumatoid arthritis (RA) is an autoimmune disease characterised by chronic synovial inflammation leading to joint destruction and bone erosions. Although the pathogenic mechanisms underlying the disease are not fully elucidated, it is known that genetic susceptibility and environmental factors trigger an abnormal autoimmune response. Potentially, any organ and tissue could be affected by RA and the increased cardiovascular (CV) risk represents the major complication responsible for a worse prognosis. In this setting, the shared pathogenic mechanisms between RA pathogenesis and accelerated atherosclerosis further strengthen the rationale for a treat-to-target strategy with synthetic and biologic disease modifying anti-rheumatic drugs. The aim of this review is to provide the novel insights, regarding the pathogenesis of RA, published over the last year.
authors.affiliation: Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Florence, Italy.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Bellucci
authors.affiliation: Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Florence, Italy. terenzi.ricca@gmail.com.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Terenzi
authors.affiliation: Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
authors.forename: Giuliana Maria Concetta
authors.initials: GM
authors.lastname: La Paglia
authors.affiliation: Rheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Gentileschi
authors.affiliation: Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Tripoli
authors.affiliation: Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Tani
authors.affiliation: Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
authors.forename: Alessia
authors.initials: A
authors.lastname: Alunno
mesh_terms: D000818:Animals; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D050197:Atherosclerosis / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D015551:Autoimmunity / Q000235:genetics; D059647:Gene-Environment Interaction; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D007596:Joints / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D008168:Lung / Q000276:immunology; D010641:Phenotype; D012307:Risk Factors
chemical_list: D018501:Antirheumatic Agents; D005819:Genetic Markers