title: The Role of High-resolution Peripheral Quantitative Computed Tomography as a Biomarker for Joint Damage in Inflammatory Arthritis.
abstract: Since 2011, members of the SPECTRA Collaboration (Study grouP for xtrEme-Computed Tomography in Rheumatoid Arthritis) have investigated the validity, reliability, and responsiveness of high-resolution peripheral quantitative computed tomography (HR-pQCT) as a biomarker for joint damage in inflammatory arthritis. Presented in this series of articles are a systematic review of HR-pQCT-related findings to date, a review of selected images of cortical and subchondral trabecular bone of metacarpophalangeal (MCP) joints, results of a consensus process to standardize the definition of erosions and their quantification, as well as an examination of the effect of joint flexion on width and volume assessment of the joint space.
authors.affiliation: From the Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.L.S. Tam, MD, Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China. lstam@cuhk.edu.hk.
authors.forename: Lai-Shan
authors.initials: LS
authors.lastname: Tam
mesh_terms: D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging*; D015415:Biomarkers; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D006801:Humans; D007596:Joints / Q000000981:diagnostic imaging*; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D015415:Biomarkers
keywords: BONE EROSION; COMPUTED TOMOGRAPHY; DIAGNOSTIC IMAGING; RHEUMATOID ARTHRITIS