title: The Pathogenesis of Resection-Associated Intestinal Adaptation.
abstract: After massive small-bowel resection, the remnant bowel compensates by a process termedadaptation. Adaptation is characterized by villus elongation and crypt deepening, which increases the capacity for absorption and digestion per unit length. The mechanisms/mediators of this important response are multiple. The purpose of this review is to highlight the major basic contributions in elucidating a more comprehensive understanding of this process.
authors.affiliation: Division of Pediatric Surgery, St. Louis Children's Hospital, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.
authors.forename: Brad W
authors.initials: BW
authors.lastname: Warner
keywords: Absorption; Adaptation; Angiogenesis; Apoptosis; EGF, epidermal growth factor; Epithelium; GH, growth hormone; GLP-2, glucagon-like peptide-2; Growth Factors; IGF-1, insulin-like growth factor-1; LA, lactate-accumulator; PN, parenteral nutrition; Proliferation; Rb, retinoblastoma protein; SBBO, small-bowel bacterial overgrowth; SBR, small-bowel resection; Villus