title: Silver-promoted decarboxylative amidation of α-keto acids with amines.
abstract: A general and effective method for the synthesis of amides through decarboxylative amidation of α-keto acids with amines has been developed. The reaction proceeded smoothly to afford the corresponding amide products in good yield under air and shows excellent functional group tolerance. In addition, the protocol can be further applied in the synthesis of heterocyclic compounds like benzimidazoles.
authors.affiliation: School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230009, P. R. China. jbhe@hfut.edu.cn and School of Medical Science, Anhui Medical University, Hefei 230026, P. R. China.
authors.forename: Xiao-Lan
authors.initials: XL
authors.lastname: Xu
authors.affiliation: School of Biological and Medical Engineering, Hefei University of Technology, Hefei 230009, P. R. China. hjxu@hfut.edu.cn.
authors.forename: Wen-Tao
authors.initials: WT
authors.lastname: Xu
authors.affiliation: School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230009, P. R. China. jbhe@hfut.edu.cn.
authors.forename: Ji-Wei
authors.initials: JW
authors.lastname: Wu
authors.affiliation: School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230009, P. R. China. jbhe@hfut.edu.cn.
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: He
authors.affiliation: School of Biological and Medical Engineering, Hefei University of Technology, Hefei 230009, P. R. China. hjxu@hfut.edu.cn.
authors.forename: Hua-Jian
authors.initials: HJ
authors.lastname: Xu