title: CD4+ T Cells Coexpressing CD134 (OX40) Harbor Significantly Increased Levels of Human Herpesvirus 6B DNA Following Umbilical Cord Blood Transplantation.
abstract: Human herpesvirus 6B (HHV-6B) commonly reactivates after umbilical cord blood transplantation (UCBT) and is associated with delayed engraftment, fever, rash, and central nervous system dysfunction. Recently, CD134 (OX40) has been implicated as a potential viral entry receptor. We evaluated CD4+CD134+/neg-loand CD8+CD134+/neg-locells at day 28 after UCBT in 20 subjects with previously documented HHV-6 reactivation and persistent viremia. Analysis of CD4+CD134+cells as compared to CD4+CD134neg-locells showed 0.308 versus 0.129 copies of HHV-6B/cell (P = .0002). CD8+CD134+/neg-locells contained little to no HHV-6B copies. Following UCBT, CD4+CD134+cells harbor significantly increased levels of HHV-6B, suggesting that CD134 (OX40) may facilitate viral entry.
authors.affiliation: Division of Blood and Marrow Transplantation, Department of Pediatrics.
authors.forename: Joshua C
authors.initials: JC
authors.lastname: Pritchett
authors.affiliation: Division of Infectious Disease, Department of Medicine, University of Minnesota Medical School, Minneapolis.
authors.forename: Jaime S
authors.initials: JS
authors.lastname: Green
authors.affiliation: Coppe Healthcare Solutions, Waukesha, Wisconsin.
authors.forename: Angela M
authors.initials: AM
authors.lastname: Thomm
authors.affiliation: Coppe Healthcare Solutions, Waukesha, Wisconsin.
authors.forename: Konstance K
authors.initials: KK
authors.lastname: Knox
authors.affiliation: Division of Blood and Marrow Transplantation, Department of Pediatrics.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Verneris
authors.affiliation: Division of Blood and Marrow Transplantation, Department of Pediatrics.
authors.forename: Troy C
authors.initials: TC
authors.lastname: Lund
mesh_terms: D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000737:chemistry / Q000821:virology*; D018414:CD8-Positive T-Lymphocytes / Q000737:chemistry / Q000821:virology; D002648:Child; D015331:Cohort Studies; D004279:DNA, Viral / Q000032:analysis* / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D005312:Fetal Blood / Q000821:virology*; D015654:Herpesvirus 6, Human / Q000302:isolation & purification*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D053262:Receptors, OX40 / Q000032:analysis*; D019349:Roseolovirus Infections / Q000821:virology*; D014180:Transplantation / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D004279:DNA, Viral; D053262:Receptors, OX40; C505716:TNFRSF4 protein, human
keywords: CD134; HHV-6; OX40; herpesvirus; umbilical cord blood transplantation