title: Value of interim FDG PET/CT for predicting outcome of patients with angioimmunoblastic T-cell lymphoma.
abstract: Subjects were 45 patients with angioimmunoblastic T-cell lymphoma (AITL) who underwent 2-[18F]-fluoro-2-deoxy-d-glucose (FDG) positron-emission tomography/computed tomography (PET/CT) at baseline and interim after 2-4 cycles. Predictors of progression-free survival (PFS) and overall survival (OS) were assessed. Positive interim PET/CT (Deauville score ≥3) was a significant independent predictor of poor PFS (Hazard ratio, 4.42; p=.028), and showed marginal significance to predict OS (p=.065). Less than 60% decrease in the average change of maximum standardized uptake value normalized by lean body mass (SULmax) also was a significant independent predictor of poor PFS (Hazard ratio, 12.96; p=.001) and poor OS (Hazard ratio, 24.11; p=.006). Interim PET/CT has a significant prognostic value for predicting PFS and OS in patients with AITL. Deauville score and percent decrease of SULmaxhave the potential to be useful parameter in classifying patients into good and poor responders.
authors.affiliation: a Departments of Nuclear Medicine and Division of Hematology-Oncology , Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul , Republic of Korea.
authors.forename: Seung Hwan
authors.initials: SH
authors.lastname: Moon
authors.affiliation: a Departments of Nuclear Medicine and Division of Hematology-Oncology , Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul , Republic of Korea.
authors.forename: Ah Young
authors.initials: AY
authors.lastname: Lee
authors.affiliation: b Department of Medicine , Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul , Republic of Korea.
authors.forename: Won-Seog
authors.initials: WS
authors.lastname: Kim
authors.affiliation: b Department of Medicine , Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul , Republic of Korea.
authors.forename: Seok Jin
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: a Departments of Nuclear Medicine and Division of Hematology-Oncology , Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul , Republic of Korea.
authors.forename: Young Seok
authors.initials: YS
authors.lastname: Cho
authors.affiliation: a Departments of Nuclear Medicine and Division of Hematology-Oncology , Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul , Republic of Korea.
authors.forename: Yearn Seong
authors.initials: YS
authors.lastname: Choe
authors.affiliation: a Departments of Nuclear Medicine and Division of Hematology-Oncology , Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul , Republic of Korea.
authors.forename: Byung-Tae
authors.initials: BT
authors.lastname: Kim
authors.affiliation: a Departments of Nuclear Medicine and Division of Hematology-Oncology , Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul , Republic of Korea.
authors.forename: Kyung-Han
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007119:Immunoblastic Lymphadenopathy / Q000000981:diagnostic imaging* / Q000473:pathology*; D053208:Kaplan-Meier Estimate; D016399:Lymphoma, T-Cell / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000473:pathology*; D063868:Patient Outcome Assessment; D000072078:Positron Emission Tomography Computed Tomography; D011241:Prednisone / Q000627:therapeutic use; D011379:Prognosis; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D019788:Fluorodeoxyglucose F18; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone
keywords: 18F-FDG; Angioimmunoblastic T-cell lymphoma; PET/CT; prognosis