title: Design, synthesis, cytotoxicities and DNA cleavage activities of dibenzoxepine and isoquinoline derivatives starting from dehydroabietylamine.
abstract: A series of novel hexahydrodibenzoxepine and quinazoline derivatives were designed and synthesized starting from dehydroabietylamine. The cytotoxicities of the compounds against L02 and HepG2 cell lines were investigated. Meanwhile, the plasmid DNA (Escherichia coli) cleavage of several heterocyclic derivatives was studied. These compounds exhibit remarkable activities on plasmid DNA pBR322. Our study provides useful information for developing new and more potent antitumor agents.
authors.affiliation: a Department of Pharmacy , Bozhou Vocational and Technical College , Bozhou 236800 , China.
authors.forename: Chao-Xiang
authors.initials: CX
authors.lastname: Liu
authors.affiliation: b College of Chemical Engineering , Nanjing Forestry University , Nanjing 210037 , China.
authors.forename: Zhong-Xiang
authors.initials: ZX
authors.lastname: Lin
authors.affiliation: c Department of Chemistry , Cleveland State University , Cleveland , OH 44115 , USA.
authors.forename: Ai-Min
authors.initials: AM
authors.lastname: Zhou
mesh_terms: D045784:Abietanes / Q000737:chemistry* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001584:Benzoxepins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D053837:DNA Cleavage; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D056945:Hep G2 Cells; D006801:Humans; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D010957:Plasmids / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D045784:Abietanes; D000970:Antineoplastic Agents; D001584:Benzoxepins; D007546:Isoquinolines; C000600819:dehydroabietylamine
keywords: DNA cleavage activity; Dehydroabietylamine; O-heterocyclic; cytotoxicity