title: Alcohol Dependence and Its Relationship With Insomnia and Other Sleep Disorders.
abstract: Sleep-related complaints are widely prevalent in those with alcohol dependence (AD). AD is associated not only with insomnia, but also with multiple sleep-related disorders as a growing body of literature has demonstrated. This article will review the various aspects of insomnia associated with AD. In addition, the association of AD with other sleep-related disorders will be briefly reviewed. The association of AD with insomnia is bidirectional in nature. The etiopathogenesis of insomnia has demonstrated multiple associations and is an active focus of research. Treatment with cognitive behavioral therapy for insomnia is showing promise as an optimal intervention. In addition, AD may be associated with circadian abnormalities, short sleep duration, obstructive sleep apnea, and sleep-related movement disorder. The burgeoning knowledge on insomnia associated with moderate-to-severe alcohol use disorder has expanded our understanding of its underlying neurobiology, clinical features, and treatment options.
authors.affiliation: Corporal Michael J. Crescenz VA Medical Center , Philadelphia, Pennsylvania. subhajit.chakravorty@uphs.upenn.edu.|Perelman School of Medicine , Philadelphia, Pennsylvania. subhajit.chakravorty@uphs.upenn.edu.
authors.forename: Subhajit
authors.initials: S
authors.lastname: Chakravorty
authors.affiliation: University of Alabama at Birmingham , Birmingham, Alabama.
authors.forename: Ninad S
authors.initials: NS
authors.lastname: Chaudhary
authors.affiliation: University of Michigan Medical School , Ann Arbor, Michigan.
authors.forename: Kirk J
authors.initials: KJ
authors.lastname: Brower
mesh_terms: D000437:Alcoholism / Q000150:complications*; D002492:Central Nervous System Depressants / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D012890:Sleep / Q000187:drug effects; D007319:Sleep Initiation and Maintenance Disorders / Q000209:etiology*
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol
keywords: Alcohol; Alcoholism; Sleep; Sleep Initiation and Maintenance Disorders