title: Acute exacerbation of irritable bowel syndrome prevented by prn oral triptan.
abstract: We report a case of irritable bowel syndrome (IBS), diarrhea subtype, characterized by daily 'morning rush' and episodic acute exacerbations brought on by common IBS trigger foods including insoluble fiber, red wine and large/rich meals. The patient also had a history of migraine headaches, and a family history suggesting a common diathesis for both disorders. Given hypothesized contributions to IBS from dysregulation of the enteric serotonergic system, a trial of low-dose triptan medication was implemented in the context of the patient's known IBS triggers, with highly satisfactory results.
authors.affiliation: Department of Psychiatry, University of California, Box 2611, 1550 4th St, Floor 2, San Francisco, CA, 94143, USA. bc@ucsf.edu.
authors.forename: Benjamin N R
authors.identifier: http://orcid.org/0000-0001-9934-7941
authors.initials: BN
authors.lastname: Cheyette
authors.affiliation: Department of Neurology, Palo Alto Medical Foundation, Palo Alto, CA, 94301, USA.
authors.forename: Sarah N R
authors.initials: SN
authors.lastname: Cheyette
mesh_terms: D000208:Acute Disease; D000284:Administration, Oral; D003937:Diagnosis, Differential; D005765:Gastrointestinal Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000175:diagnosis / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D014363:Tryptamines / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D005765:Gastrointestinal Agents; D014363:Tryptamines
keywords: Diarrhea; Food trigger; Irritable bowel syndrome; Morning rush; Pharmacotherapy; Relief; Triptan; Zolmitriptan