title: Peroxisome proliferator-activated receptor gamma co-activator 1 gene Gly482Ser polymorphism is associated with the response of low-density lipoprotein cholesterol concentrations to exercise training in elderly Japanese.
abstract: Muscle peroxisome proliferator-activated receptor gamma co-activator 1 (PGC-1)α gene expression is influenced by the Gly482Ser gene polymorphism, which is a candidate genetic risk factor for diabetes mellitus and obesity. This study investigated the effects of PGC-1 gene Gly482Ser polymorphisms on alterations in glucose and lipid metabolism induced by exercise training. A 12-week intervention study was performed for 119 participants who were more than 65 years of age and completed exercise training at lactate threshold intensity. Total cholesterol and low-density lipoprotein cholesterol were significantly reduced in Gly/Gly but not in Gly/Ser and Ser/Ser participants after exercise. The Gly/Gly genotype of the PGC-1 gene Gly482Ser polymorphism influences the effects of moderate-intensity exercise training on low-density lipoprotein cholesterol and total cholesterol concentrations in older people.
authors.affiliation: Faculty of Nursing and Nutrition, University of Nagasaki, Manabino1-1-1, Nagayo-cho, Nishisonogi-gun, Nagasaki, 851-2195, Japan. tobitaku@sun.ac.jp.|The Fukuoka University Institute for Physical Activity, Fukuoka University, Fukuoka, Japan. tobitaku@sun.ac.jp.
authors.forename: Takuro
authors.initials: T
authors.lastname: Tobina
authors.affiliation: Faculty of Sports Science, Fukuoka University, Fukuoka, Japan.
authors.forename: Yukari
authors.initials: Y
authors.lastname: Mori
authors.affiliation: The Fukuoka University Institute for Physical Activity, Fukuoka University, Fukuoka, Japan.|Faculty of Commerce, Department of Tourism Industry, Kyushu Sangyo University, Fukuoka, Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Doi
authors.affiliation: Faculty of Sports Science, Fukuoka University, Fukuoka, Japan.
authors.forename: Fuki
authors.initials: F
authors.lastname: Nakayama
authors.affiliation: The Fukuoka University Institute for Physical Activity, Fukuoka University, Fukuoka, Japan.|Faculty of Sports Science, Fukuoka University, Fukuoka, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Kiyonaga
authors.affiliation: The Fukuoka University Institute for Physical Activity, Fukuoka University, Fukuoka, Japan.|Faculty of Sports Science, Fukuoka University, Fukuoka, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Tanaka
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D008078:Cholesterol, LDL / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D015444:Exercise / Q000502:physiology*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D009765:Obesity / Q000235:genetics; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / Q000235:genetics* / Q000378:metabolism*; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D008078:Cholesterol, LDL; C486497:PPARGC1A protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
keywords: Atherosclerosis; Diabetes mellitus; Hyperlipidemia; Mitochondria; Moderate-intensity exercise