title: Experimental Infection Models of Tuberculosis in Domestic Livestock.
abstract: In this article we present experimental Mycobacterium bovis infection models in domestic livestock species and how these models were applied to vaccine development, biomarker discovery, and the definition of specific antigens for the differential diagnosis of infected and vaccinated animals. In particular, we highlight synergies between human and bovine tuberculosis (TB) research approaches and data and propose that the application of bovine TB models could make a valuable contribution to human TB vaccine research and that close alignment of both research programs in a one health philosophy will lead to mutual and substantial benefits.
authors.affiliation: AgResearch, Hopkirk Research Institute, Palmerston North, New Zealand.
authors.forename: Bryce M
authors.initials: BM
authors.lastname: Buddle
authors.affiliation: Animal and Plant Health Agency - Weybridge, Addlestone, Surrey, United Kingdom.
authors.forename: H Martin
authors.initials: HM
authors.lastname: Vordermeier
authors.affiliation: AgResearch, Hopkirk Research Institute, Palmerston North, New Zealand.
authors.forename: R Glyn
authors.initials: RG
authors.lastname: Hewinson
mesh_terms: D000818:Animals; D002417:Cattle; D003670:Deer; D004195:Disease Models, Animal; D006041:Goats; D058751:Livestock; D009164:Mycobacterium Infections; D009163:Mycobacterium bovis / Q000276:immunology* / Q000472:pathogenicity*; D014376:Tuberculosis / Q000175:diagnosis / Q000276:immunology / Q000473:pathology*; D032581:Tuberculosis Vaccines / Q000276:immunology / Q000302:isolation & purification
chemical_list: D032581:Tuberculosis Vaccines