title: Pd-Catalyzed Aminocarbonylation of the Blaise Reaction Intermediate: One-Pot Synthesis of (Z)-3-Methyleneisoindolin-1-ones from Nitriles.
abstract: A highly efficient method for the one-pot synthesis of stereocontrolled (Z)-3-methyleneisoindolin-1-ones was developed starting from 2-bromoarylnitriles via tandem sequential reaction with a Reformatsky reagent (Blaise reaction), followed by Pd-catalyzed intramolecular aminocarbonylation with carbon monoxide at 1 atm pressure. It has been found that the conformational flexibility of the bisphophine ligand is of great importance to the success of this tandem aminocarbonylation reaction.
authors.affiliation: Department of Chemistry and Nano Science, Ewha Womans University , 120-750 Seoul, Korea.
authors.forename: Zi
authors.initials: Z
authors.lastname: Xuan
authors.affiliation: Department of Chemistry and Nano Science, Ewha Womans University , 120-750 Seoul, Korea.
authors.forename: Da Jung
authors.initials: DJ
authors.lastname: Jung
authors.affiliation: Department of Chemistry and Nano Science, Ewha Womans University , 120-750 Seoul, Korea.
authors.forename: Hyun Ji
authors.initials: HJ
authors.lastname: Jeon
authors.affiliation: Department of Chemistry and Nano Science, Ewha Womans University , 120-750 Seoul, Korea.
authors.forename: Sang-Gi
authors.initials: SG
authors.lastname: Lee