title: C-terminal domains of bacterial proteases: structure, function and the biotechnological applications.
abstract: C-terminal domains widely exist in the C-terminal region of multidomain proteases. As a β-sandwich domain in multidomain protease, the C-terminal domain plays an important role in proteolysis including regulation of the secretory process, anchoring and swelling the substrate molecule, presenting as an inhibitor for the preprotease and adapting the protein structural flexibility and stability. In this review, the diversity, structural characteristics and biological function of C-terminal protease domains are described. Furthermore, the application prospects of C-terminal domains, including polycystic kidney disease, prepeptidase C-terminal and collagen-binding domain, in the area of medicine and biological artificial materials are also discussed.
authors.affiliation: State Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, China.
authors.forename: J
authors.initials: J
authors.lastname: Huang
authors.affiliation: State Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, China.
authors.forename: C
authors.initials: C
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, China.
authors.forename: D
authors.initials: D
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, China.
authors.forename: X
authors.initials: X
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, China.
authors.forename: R
authors.initials: R
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, China.
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, China.
authors.forename: C
authors.initials: C
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, China.
authors.forename: H
authors.initials: H
authors.lastname: He
mesh_terms: D000595:Amino Acid Sequence; D001419:Bacteria / Q000201:enzymology*; D001709:Biotechnology / Q000379:methods*; D008958:Models, Molecular; D010447:Peptide Hydrolases / Q000737:chemistry* / Q000378:metabolism*; D017434:Protein Structure, Tertiary
chemical_list: D010447:Peptide Hydrolases
keywords: C-terminal protease domain; bacteria; biotechnology; diversity; function; structural characteristics