title: Clinical Trials of Aspirin Treatment After Desensitization in Aspirin-Exacerbated Respiratory Disease.
abstract: The clinical efficacy of aspirin treatment after desensitization in patients with respiratory disease exacerbated by nonsteroidal anti-inflammatory drugs has been documented in observational studies and in double-blind placebo-controlled trials. There is no general agreement with regard to the optimal maintenance dose or duration of treatment with acetylsalicylic acid after desensitization, thus further studies are necessary to offer clear guidelines to clinicians. This article summarizes data from noncontrolled, active-control, and placebo-controlled trials assessing clinical effectiveness and reporting on safety of treatment with acetylsalicylic acid in desensitized patients with respiratory disease exacerbated by nonsteroidal anti-inflammatory drugs.
authors.affiliation: Department of Immunology, Rheumatology and Allergy, Healthy Ageing Research Center, Medical University of Łódź, 251 Pomorska Street, Łódź 92-213, Poland. Electronic address: Marek.Kowalski@csk.umed.lodz.pl.
authors.forename: Marek L
authors.initials: ML
authors.lastname: Kowalski
authors.affiliation: Department of Immunology, Rheumatology and Allergy, Healthy Ageing Research Center, Medical University of Łódź, 251 Pomorska Street, Łódź 92-213, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Wardzyńska
authors.affiliation: Department of Rheumatology, Medical University of Łódź, 30 Pieniny Street, Łódź 92-115, Poland.
authors.forename: Joanna S
authors.initials: JS
authors.lastname: Makowska
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D001241:Aspirin / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003888:Desensitization, Immunologic; D004342:Drug Hypersensitivity / Q000209:etiology / Q000628:therapy; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D012140:Respiratory Tract Diseases / Q000209:etiology / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin
keywords: Aspirin desensitization; Aspirin hypersensitivity; Asthma; Chronic rhinosinusitis; NSAIDs-exacerbated respiratory disease; Nonsteroidal anti-inflammatory drugs