title: Primary Central Nervous System Anaplastic Large T-cell Lymphoma.
abstract: Primary central nervous system lymphoma (PCNSL) of T-cell origin is an exceptionally rare, highly malignant intracranial neoplasm. Although such a tumor typically presents with a focal mass lesion.
  
  
  
  Past medical history of a 26-year-old male patient with a PCNS lymphoma of T-cell origin was not suggestive of intracranial pathology or any disorder of other organs and organic systems. To achieve a gross total tumor resection, surgery was performed via osteoplastic craniotomy using the left frontal transcortical transventricular approach. Histological and immunohistochemical analyses of the tissue removed described tumor as anaplastic large cell lymphoma of T-cells (T-ALCL). Postoperative and neurological recovery was complete, while control imaging of the brain showed no signs of residual tumor at a six-month follow-up. The patient, who did not appear immunocompromized, was referred to a hematologist and an oncologist where corticosteroids, the particular chemotherapeutic protocol and irradiation therapy were applied.
  
  
  
  Since PCNS lymphoma is a potentially curable brain tumor, we believe that proper selection of the management options, including early radical tumor resection for solitary PCNS lymphoma, may be proposed as a major treatment of such a tumor in selected patients, resulting in a satisfactory outcome.
authors.affiliation: Department of Neurosurgery, "J. J. Strossmayer" University of Osijek School of Medicine, Osijek, Croatia.
authors.forename: Bruno
authors.initials: B
authors.lastname: Splavski
authors.affiliation: Department of Neurosurgery, "J. J. Strossmayer" University of Osijek School of Medicine, Osijek, Croatia.
authors.forename: Dario
authors.initials: D
authors.lastname: Muzevic
authors.affiliation: Division of Hematology, Department of Internal Medicine, "J. J. Strossmayer" University of Osijek School of Medicine, Osijek, Croatia.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Ladenhauser-Palijan
authors.affiliation: Division of Ophthalmology, Osijek Clinical Hospital Center, Osijek, Croatia.
authors.forename: Brano
authors.initials: B
authors.lastname: Splavski
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000175:diagnosis* / Q000628:therapy*; D008297:Male
keywords: Outcome; Primary central nervous system lymphoma of T-cell origin; Protocol Options; Radical Surgery