title: Optical analysis of enamel and dentin caries in relation to mineral density using swept-source optical coherence tomography.
abstract: The aim of this study was to evaluate the signal intensity and signal attenuation of swept source optical coherence tomography (SS-OCT) for dental caries in relation to the variation of mineral density. SS-OCT observation was performed on the enamel and dentin artificial demineralization and on natural caries. The artificial caries model on enamel and dentin surfaces was created usingStreptococcus mutansbiofilms incubated in an oral biofilm reactor. The lesions were centrally cross sectioned and SS-OCT scans were obtained in two directions to construct a three-dimensional data set, from the lesion surface (sagittal scan) and parallel to the lesion surface (horizontal scan). The integrated signal up to [Formula: see text] in depth (IS200) and the attenuation coefficient ([Formula: see text]) of the enamel and dentin lesions were calculated from the SS-OCT signal in horizontal scans at five locations of lesion depth. The values were compared with the mineral density obtained from transverse microradiography. Both enamel and dentin demineralization showed significantly higher IS200 and [Formula: see text] than the sound tooth substrate from the sagittal scan. Enamel demineralization showed significantly higher IS200 than sound enamel, even with low levels of demineralization. In demineralized dentin, the [Formula: see text] from the horizontal scan consistently trended downward compared to the sound dentin.
authors.affiliation: Graduate School of Tokyo Medical and Dental University , Department of Cariology and Operative Dentistry, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
authors.forename: Tomoka
authors.initials: T
authors.lastname: Ueno
authors.affiliation: Graduate School of Tokyo Medical and Dental University , Department of Cariology and Operative Dentistry, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Shimada
authors.affiliation: Tsurumi University , School of Dental Medicine, Endowed Department of International Oral Health Science, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama City, Kanagawa, Japan.
authors.forename: Khairul
authors.initials: K
authors.lastname: Matin
authors.affiliation: Graduate School of Tokyo Medical and Dental University , Department of Cariology and Operative Dentistry, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Graduate School of Tokyo Medical and Dental University , Department of Cariology and Operative Dentistry, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
authors.forename: Ikumi
authors.initials: I
authors.lastname: Wada
authors.affiliation: University of Washington School of Dentistry , Department of Restorative Dentistry, 1959 NE Pacific Street, Seattle, Washington 98195, United States.
authors.forename: Alireza
authors.initials: A
authors.lastname: Sadr
authors.affiliation: National Center for Geriatrics and Gerontology , Center of Advanced Medicine for Dental and Oral Diseases, Department for Advanced Dental Research 7-430 Morioka-cho, Obu City, Aichi, Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Sumi
authors.affiliation: Graduate School of Tokyo Medical and Dental University , Department of Cariology and Operative Dentistry, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
authors.forename: Junji
authors.initials: J
authors.lastname: Tagami
keywords: caries; dentin; enamel; integrated signal; optical coherence tomography; signal attenuation coefficient