title: Structure-activity of antifungal compounds inspired by aminobisabolenes from the sponge Halichondria sp.
abstract: Structure-activity relationships of the antifungal aminobisabolene natural product, 1 isolated from Halichondria sp., and synthetic analogs were explored, in parallel with the antidermatophytic allylamine, Terbinafine®, against a panel of pathogenic fungi: Candida spp., Cryptococcus spp. and Trichophyton rubrum. Interpretation of the results suggest different modes of action in antifungal activity for the two classes of compounds.
authors.affiliation: Department of Chemistry and Biochemistry and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States.
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Jamison
authors.affiliation: Department of Chemistry and Biochemistry and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States.
authors.forename: Jocelyn
authors.initials: J
authors.lastname: Macho
authors.affiliation: Department of Chemistry and Biochemistry and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States. Electronic address: tmolinski@ucsd.edu.
authors.forename: Tadeusz F
authors.initials: TF
authors.lastname: Molinski
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D003454:Cryptococcus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011161:Porifera; D013329:Structure-Activity Relationship; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000935:Antifungal Agents
keywords: Allylamine; Antifungal; Synthesis; Terpenoid