title: The effect of high-fat diet consumption on appetitive instrumental behavior in rats.
abstract: Evidence now indicates that the chronic consumption of high-calorie foods, such as a high-fat diet (HFD), is associated with impaired control over food-seeking, yet the extent of this alteration is not fully understood. Using different reinforcement schedules, we evaluated whether HFD intake from weaning to adulthood modifies instrumental responding and induces a shift from goal-directed actions to habitual responding. We first observed reduced instrumental performance and motivation for a food reward in HFD-fed rats trained under schedules of reinforcement that facilitate habitual responding [Random Interval (RI)]. However, this deficit was alleviated if rats trained under RI were subsequently trained with reinforcement schedules that promote goal-directed strategies [Random Ratio (RR)]. Using an outcome devaluation procedure, we then demonstrated that consumption of a HFD promoted habitual behavior in rats trained under RI but not RR schedules. Finally, extended HFD exposure did not interfere with the ability of RR training to overcome impaired RI instrumental performance and to favor goal-directed behavior. These results indicate that chronic consumption of a HFD changes the co-ordination of goal-directed actions and habits and that alteration of food-seeking may be reversed under particular behavioral conditions.
authors.affiliation: INRA, Nutrition et Neurobiologie Intégrée, UMR 1286, Bordeaux, France; Bordeaux University, Bordeaux, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Tantot
authors.affiliation: INRA, Nutrition et Neurobiologie Intégrée, UMR 1286, Bordeaux, France; Bordeaux University, Bordeaux, France; CNRS, Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, UMR 5287, Bordeaux, France.
authors.forename: Shauna L
authors.initials: SL
authors.lastname: Parkes
authors.affiliation: Bordeaux University, Bordeaux, France; CNRS, Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, UMR 5287, Bordeaux, France.
authors.forename: Alain R
authors.initials: AR
authors.lastname: Marchand
authors.affiliation: INRA, Nutrition et Neurobiologie Intégrée, UMR 1286, Bordeaux, France; Bordeaux University, Bordeaux, France.
authors.forename: Chloé
authors.initials: C
authors.lastname: Boitard
authors.affiliation: Bordeaux University, Bordeaux, France; CNRS, Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, UMR 5287, Bordeaux, France.
authors.forename: Fabien
authors.initials: F
authors.lastname: Naneix
authors.affiliation: INRA, Nutrition et Neurobiologie Intégrée, UMR 1286, Bordeaux, France; Bordeaux University, Bordeaux, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Layé
authors.affiliation: INRA, Nutrition et Neurobiologie Intégrée, UMR 1286, Bordeaux, France; Bordeaux University, Bordeaux, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Trifilieff
authors.affiliation: Bordeaux University, Bordeaux, France; CNRS, Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, UMR 5287, Bordeaux, France.
authors.forename: Etienne
authors.initials: E
authors.lastname: Coutureau
authors.affiliation: INRA, Nutrition et Neurobiologie Intégrée, UMR 1286, Bordeaux, France; Bordeaux University, Bordeaux, France. Electronic address: guillaume.ferreira@bordeaux.inra.fr.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Ferreira
mesh_terms: D000818:Animals; D001070:Appetitive Behavior; D003072:Cognition Disorders / Q000209:etiology*; D003216:Conditioning, Operant; D059305:Diet, High-Fat / Q000009:adverse effects*; D005247:Feeding Behavior; D007859:Learning Disabilities / Q000209:etiology*; D008297:Male; D009765:Obesity / Q000209:etiology / Q000503:physiopathology*; D020318:Rats, Long-Evans; D012055:Reinforcement Schedule; D012201:Reward; D013997:Time Factors; D014886:Weaning
keywords: Action; Diet; Habit; Obesity; Operant conditioning; Outcome devaluation