title: Advanced glycation end-products are a risk for muscle weakness in Japanese patients with type 1 diabetes.
abstract: Accumulation of advanced glycation end-products (AGEs) is thought to contribute to muscle weakness in a diabetic animal model. Skin autofluorescence is a proposed marker for accumulation of AGEs in the skin. We aimed to investigate the relationship between AGEs accumulation, sarcopenia and muscle function of Japanese patients with type 1 diabetes. A total of 36 patients with type 1 diabetes participated in the present cross-sectional study. Sarcopenia parameters (skeletal muscle mass index and knee extension strength) were compared with subcutaneous AGEs accumulation using skin autofluorescence. The prevalence of sarcopenia and impaired knee extension strength was 16.6% (men 0.0%, women 22.2%) and 47.2% (men 22.2%, women 55.6%), respectively. Knee extension strength was negatively correlated with skin autofluorescence (r² = 0.14, P < 0.05), but not with skeletal muscle mass index. In conclusion, the AGEs accumulation might be one of the reasons of impaired lower limb muscle function in Japanese patients with type 1 diabetes.
authors.affiliation: Diabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Mori
authors.affiliation: Diabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.
authors.forename: Akio
authors.initials: A
authors.lastname: Kuroda
authors.affiliation: Department of Nutrition and Metabolism, Institute of Biomedical sciences, Tokushima University Graduate School, Tokushima, Japan.
authors.forename: Michiko
authors.initials: M
authors.lastname: Araki
authors.affiliation: Diabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.
authors.forename: Reiko
authors.initials: R
authors.lastname: Suzuki
authors.affiliation: Diabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Taniguchi
authors.affiliation: Diabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.
authors.forename: Motoyuki
authors.initials: M
authors.lastname: Tamaki
authors.affiliation: Diabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Akehi
authors.affiliation: Diabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.
authors.forename: Munehide
authors.initials: M
authors.lastname: Matsuhisa
mesh_terms: D044466:Asian People; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000453:epidemiology; D005260:Female; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000150:complications* / Q000453:epidemiology / Q000378:metabolism*; D012307:Risk Factors; D055948:Sarcopenia / Q000150:complications* / Q000453:epidemiology / Q000378:metabolism*
chemical_list: D017127:Glycation End Products, Advanced
keywords: Advanced glycation end-products; Sarcopenia; Type 1 diabetes