title: Relationship between Vitamin D and the development of atrial fibrillation after on-pump coronary artery bypass graft surgery.
abstract: BACKGROUND
  Vitamin D deficiency is associated with many diverse cardiovascular disorders, such as hypertension, heart failure, stroke, coronary artery disease and atrial fibrillation. The relationship between Vitamin D and the development of atrial fibrillation after coronary artery bypass surgery (CABG) has not been studied. Therefore, we assessed the relationship between Vitamin D and the development of postoperative atrial fibrillation (POAF) after CABG.
  
  
  METHODS
  Medical records of consecutive patients who underwent CABG surgery were retrospectively reviewed for the development of atrial fibrillation in the postoperative period. Vitamin D, other biochemical parameters, and clinical and echocardiographic parameters were evaluated in all patients. The independent variables for the development of postoperative atrial fibrillation were defined and their predictive values were measured.
  
  
  RESULTS
  The study group consisted of 128 patients, of whom 41 (32%) developed POAF. Age, diabetes mellitus, chronic obstructive pulmonary disease, history of transient ischaemic attack/stroke, heart failure, left atrial diameter, platelet:largecell ratio, and creatinine, urea, uric acid, calcium and potassium levels were identified as important variables for the development of POAF. However, with logistic regression analysis, chronic obstructive pulmonary disease (OR: 28.737, 95% CI: 0.836-16.118, p < 0.001), heart failure (OR: 15.430, 95% CI: 0.989-7.649, p = 0.006), diabetes mellitus (OR: 11.486, 95% CI: 0.734-11.060, p = 0.001) and left atrial diameter (OR: 1.245, 95% CI: 0.086-6.431, p = 0.011) appeared as independent variables predicting the development of POAF.
  
  
  CONCLUSIONS
  In our study, although there was a significant negative correlation between Vitamin D and left atrial diameter, Vitamin D level was not an independent predictor for POAF.
authors.affiliation: Near East University, Nicosia, Cyprus. Email: drcerit@hotmail.com.
authors.forename: Levent
authors.initials: L
authors.lastname: Cerit
authors.affiliation: Near East University, Nicosia, Cyprus.
authors.forename: Hatice
authors.initials: H
authors.lastname: Kemal
authors.affiliation: Near East University, Nicosia, Cyprus.
authors.forename: Kamil
authors.initials: K
authors.lastname: Gulsen
authors.affiliation: Near East University, Nicosia, Cyprus.
authors.forename: Barcin
authors.initials: B
authors.lastname: Ozcem
authors.affiliation: Near East University, Nicosia, Cyprus.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Cerit
authors.affiliation: Near East University, Nicosia, Cyprus.
authors.forename: Hamza
authors.initials: H
authors.lastname: Duygu
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000175:diagnosis / Q000209:etiology*; D015415:Biomarkers / Q000097:blood; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications* / Q000175:diagnosis
chemical_list: D015415:Biomarkers; D014807:Vitamin D; C104450:25-hydroxyvitamin D