title: Hypersensitivity to aspirin and urgent percutaneous coronary intervention: A therapeutic challenge.
abstract: Hypersensitivity reactions to nonsteroidal anti-inflammatory drugs are common and five types of reactions have been defined. The prevalence of such reactions in patients with myocardial infarction is unclear, and so antiplatelet therapy in this population is a challenge. Various desensitization protocols have been developed but there are no specific guidelines for their use. The authors present the case of a patient with acute coronary syndrome and aspirin hypersensitivity referred for urgent coronary angiography. Aspirin desensitization therapy is safe and successful in many patients, but more randomized trials are needed to confirm its benefits in coronary artery disease patients.
authors.affiliation: Serviço de Cardiologia, Centro Hospitalar de Setúbal, Setúbal, Portugal. Electronic address: taty_isabel@hotmail.com.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Duarte
authors.affiliation: Serviço de Cardiologia, Centro Hospitalar de Setúbal, Setúbal, Portugal.
authors.forename: Sara
authors.initials: S
authors.lastname: Gonçalves
authors.affiliation: Serviço de Cardiologia, Centro Hospitalar de Setúbal, Setúbal, Portugal.
authors.forename: Catarina
authors.initials: C
authors.lastname: Sá
authors.affiliation: Serviço de Cardiologia, Centro Hospitalar de Setúbal, Setúbal, Portugal.
authors.forename: Rita
authors.initials: R
authors.lastname: Marinheiro
authors.affiliation: Serviço de Cardiologia, Centro Hospitalar de Setúbal, Setúbal, Portugal.
authors.forename: Rita
authors.initials: R
authors.lastname: Rodrigues
authors.affiliation: Serviço de Cardiologia, Centro Hospitalar de Setúbal, Setúbal, Portugal.
authors.forename: Filipe
authors.initials: F
authors.lastname: Seixo
authors.affiliation: Serviço de Imunoalergologia, Centro Hospitalar de Setúbal, Setúbal, Portugal.
authors.forename: Elza
authors.initials: E
authors.lastname: Tomas
authors.affiliation: Serviço de Cardiologia, Centro Hospitalar de Setúbal, Setúbal, Portugal.
authors.forename: Rui
authors.initials: R
authors.lastname: Caria
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D003888:Desensitization, Immunologic / Q000379:methods*; D004342:Drug Hypersensitivity / Q000145:classification / Q000628:therapy*; D005260:Female; D006801:Humans; D062645:Percutaneous Coronary Intervention
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin
keywords: Acute coronary syndrome; Desensitization protocols; Hipersensibilidade aos anti‐inflamatórios não‐esteroides; Hypersensitivity to nonsteroidal anti‐inflammatory drugs; Protocolos de dessensibilização; Síndrome coronária aguda