title: Efficacy of daiokanzoto in chronic constipation refractory to first-line laxatives.
abstract: There are only a few treatment options for constipation and limited evidence of suitable treatments. Daiokanzoto (DKT) is a Kampo medicine often used clincally to treat constipation. DKT is a laxative used predominantly in Japan; however, clinical data on its efficacy and safety is lacking. Patients who used DKT, but were intolerant to either magnesium oxide (MgO; MgO group; n=16) or senna extract (Senna group; n=26) were included in the present study. The frequencies of their bowel movements were compared during the 1 week prior to and following DKT administration. Within 24 hours after DKT administration, 93.8% of the patients in the MgO group evacuated their bowels. The median bowel movement frequency 1 week prior to DKT administration was 2.5 and 1 week after DKT administration was significantly increased to 7.5. In the Senna group, within 24 h of DKT administration, 80.8% of the patients evacuated their bowels. The median bowel movement frequency 1 week prior to the DKT treatment was 2.0, which significantly increased to 8.5 1 week after the administration of DKT. The adverse events from DKT treatment were mild and controllable.
authors.affiliation: Department of Pharmacy, Ogaki Municipal Hospital, Ogaki-shi, Gifu 503-8502, Japan; Laboratory of Pharmacy Practice and Social Science, Gifu Pharmaceutical University, Gifu-shi, Gifu 501-1196, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Hirose
authors.affiliation: Department of Pharmacy, Ogaki Municipal Hospital, Ogaki-shi, Gifu 503-8502, Japan; Laboratory of Pharmacy Practice and Social Science, Gifu Pharmaceutical University, Gifu-shi, Gifu 501-1196, Japan.
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Shinoda
authors.affiliation: Department of Pharmacy, Ogaki Municipal Hospital, Ogaki-shi, Gifu 503-8502, Japan.
authors.forename: Aya
authors.initials: A
authors.lastname: Yoshida
authors.affiliation: Department of Pharmacy, Ogaki Municipal Hospital, Ogaki-shi, Gifu 503-8502, Japan.
authors.forename: Machiko
authors.initials: M
authors.lastname: Kurimoto
authors.affiliation: Department of Pharmacy, Ogaki Municipal Hospital, Ogaki-shi, Gifu 503-8502, Japan.
authors.forename: Kouki
authors.initials: K
authors.lastname: Mori
authors.affiliation: Department of Pharmacy, Ogaki Municipal Hospital, Ogaki-shi, Gifu 503-8502, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kawachi
authors.affiliation: Department of Pharmacy, Ogaki Municipal Hospital, Ogaki-shi, Gifu 503-8502, Japan.
authors.forename: Kouji
authors.initials: K
authors.lastname: Tanaka
authors.affiliation: Department of Pharmacy, Ogaki Municipal Hospital, Ogaki-shi, Gifu 503-8502, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Takeda
authors.affiliation: Department of Pharmacy, Ogaki Municipal Hospital, Ogaki-shi, Gifu 503-8502, Japan; Laboratory of Pharmacy Practice and Social Science, Gifu Pharmaceutical University, Gifu-shi, Gifu 501-1196, Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Yoshimura
authors.affiliation: Laboratory of Pharmacy Practice and Social Science, Gifu Pharmaceutical University, Gifu-shi, Gifu 501-1196, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Sugiyama
keywords: MgO; Senna; Sennoside A; constipation; daiokanzoto