title: Effects of Antihypertensive Therapy on Blood Pressure Variability.
abstract: The study aims to summarize the effect of antihypertensive therapy on various types of BP variability in hypertensives.
  
  
  
  Visit-to-visit, day-by-day, and ambulatory BPV are markers of target organ damage and cardiovascular prognosis, as was shown in the LIFE study, which showed that visit-to-visit variability in BP predicted cardiovascular events in treated hypertensive patients with left ventricular hypertrophy. Long-acting calcium channel blockers (CCBs) may be a preferable treatment in reducing BPV measures. Non-adherence to antihypertensive medication is also a very important component of increased BPV, and improving the adherence is also a key for the favorable prognosis. BPV cannot be a target of antihypertensive treatments because of the lack of definitive evidence. However, in high-risk patients, those with cardiovascular or cerebrovascular diseases, the clinical significance should be considered in individual basis. Especially, reduction of BPV would be an important strategy for these patients.
authors.affiliation: Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University, Shimotsuke, Tochigi, 329-0498, Japan. ke112@jichi.ac.jp.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Eguchi
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D001795:Blood Pressure Determination; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D011379:Prognosis
chemical_list: D000959:Antihypertensive Agents
keywords: Antihypertensive therapy; BPV; Blood pressure; Variability in blood pressure