title: Three structurally-related impurities in norvancomycin drug substance.
abstract: Norvancomycin (NVCM) is widely used in China to treat bacterial infections of Gram-positive cocci and bacilli, especially infections of methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus epidermidis. This study is a chemical investigation of the drug substance of NVCM, and led to the identification, by 1D, 2D NMR spectra and HRESIMS, of three as yet undescribed impurities, one D-O-E ring expanded NVCM analog (1) and two derivatives of NVCM lacking sugars (2, 3).
authors.affiliation: Key Laboratory of Biotechnology of Antibiotics, the National Health and Family Planning Commission (NHFPC); Department of Biotechnology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Zhibo
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Key Laboratory of Biotechnology of Antibiotics, the National Health and Family Planning Commission (NHFPC); Department of Biotechnology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Lei
authors.affiliation: Key Laboratory of Biotechnology of Antibiotics, the National Health and Family Planning Commission (NHFPC); Department of Biotechnology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Minghua
authors.initials: M
authors.lastname: Chen
authors.affiliation: Key Laboratory of Biotechnology of Antibiotics, the National Health and Family Planning Commission (NHFPC); Department of Biotechnology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Bingya
authors.initials: B
authors.lastname: Jiang
authors.affiliation: Key Laboratory of Biotechnology of Antibiotics, the National Health and Family Planning Commission (NHFPC); Department of Biotechnology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Linzhuan
authors.initials: L
authors.lastname: Wu
authors.affiliation: New Drug Research and Development Center, North China Pharmaceutical Group Corporation, Hebei China.
authors.forename: Xuexia
authors.initials: X
authors.lastname: Zhang
authors.affiliation: New Drug Research and Development Center, North China Pharmaceutical Group Corporation, Hebei China.
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Zheng
authors.affiliation: Key Laboratory of Biotechnology of Antibiotics, the National Health and Family Planning Commission (NHFPC); Department of Biotechnology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Xinxin
authors.initials: X
authors.lastname: Hu
authors.affiliation: Key Laboratory of Biotechnology of Antibiotics, the National Health and Family Planning Commission (NHFPC); Department of Biotechnology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Xuefu
authors.initials: X
authors.lastname: You
authors.affiliation: Key Laboratory of Biotechnology of Antibiotics, the National Health and Family Planning Commission (NHFPC); Department of Biotechnology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Shuyi
authors.initials: S
authors.lastname: Si
authors.affiliation: Key Laboratory of Biotechnology of Antibiotics, the National Health and Family Planning Commission (NHFPC); Department of Biotechnology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Lifei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Key Laboratory of Biotechnology of Antibiotics, the National Health and Family Planning Commission (NHFPC); Department of Biotechnology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Hong
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D004340:Drug Contamination; D015394:Molecular Structure; D014640:Vancomycin / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin; C511195:norvancomycin