title: Lactate release from astrocytes to neurons contributes to cocaine memory formation.
abstract: The identification of neural substrates underlying the long lasting debilitating impact of drug cues is critical for developing novel therapeutic tools. Metabolic coupling has long been considered a key mechanism through which astrocytes and neurons actively interact in response of neuronal activity, but recent findings suggested that disrupting metabolic coupling may represent an innovative approach to prevent memory formation, in particular drug-related memories. Here, we review converging evidence illustrating how memory and addiction share neural circuitry and molecular mechanisms implicating lactate-mediated metabolic coupling between astrocytes and neurons. With several aspects of addiction depending on mnemonic processes elicited by drug experience, disrupting lactate transport involved in the formation of a pathological learning, linking the incentive, and motivational effects of drugs with drug-conditioned stimuli represent a promising approach to encourage abstinence.
authors.affiliation: Department of Psychiatry, Centre for Psychiatric Neuroscience, Lausanne University Hospital, Lausanne, Switzerland.|Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Boury-Jamot
authors.affiliation: Division of Child and Adolescent Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.
authors.forename: Olivier
authors.initials: O
authors.lastname: Halfon
authors.affiliation: Department of Psychiatry, Centre for Psychiatric Neuroscience, Lausanne University Hospital, Lausanne, Switzerland.|Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.|King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
authors.forename: Pierre J
authors.initials: PJ
authors.lastname: Magistretti
authors.affiliation: Department of Psychiatry, Centre for Psychiatric Neuroscience, Lausanne University Hospital, Lausanne, Switzerland.|Division of Child and Adolescent Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Boutrel
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000378:metabolism / Q000502:physiology*; D019970:Cocaine-Related Disorders / Q000503:physiopathology* / Q000523:psychology; D003213:Conditioning, Psychological; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism*; D008568:Memory; D009042:Motivation; D009474:Neurons / Q000502:physiology*
chemical_list: D019344:Lactic Acid
keywords: astrocyte; cocaine; conditioning; lactate; memory