title: Mucus-Penetrating Nanosuspensions for Enhanced Delivery of Poorly Soluble Drugs to Mucosal Surfaces.
abstract: Mucus-penetrating nanosuspensions, consisting of pure hydrophobic therapeutics with dense muco-inert coatings that enable particles to effectively bypass the mucus barrier, demonstrate superior drug distribution and absorption at mucosal surfaces. With significantly increased drug load compared to polymeric systems and established clinical translation of nanosuspensions-based products, mucus-penetrating nanosuspensions are a promising vehicle for improving mucosal delivery of poorly soluble drugs.
authors.affiliation: Center for Nanomedicine, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 N Broadway, Baltimore, MD, 21231, USA.|Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD, 21205, USA.
authors.forename: Tao
authors.initials: T
authors.lastname: Yu
authors.affiliation: Center for Nanomedicine, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 N Broadway, Baltimore, MD, 21231, USA.|Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD, 21218, USA.
authors.forename: Jane
authors.initials: J
authors.lastname: Chisholm
authors.affiliation: Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD, 21205, USA.
authors.forename: Woo Jin
authors.initials: WJ
authors.lastname: Choi
authors.affiliation: Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD, 21218, USA.
authors.forename: Abraham
authors.initials: A
authors.lastname: Anonuevo
authors.affiliation: Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD, 21218, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Pulicare
authors.affiliation: Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD, 21205, USA.
authors.forename: Weixi
authors.initials: W
authors.lastname: Zhong
authors.affiliation: Center for Nanomedicine, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 N Broadway, Baltimore, MD, 21231, USA.
authors.forename: Minmin
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD, 21218, USA.
authors.forename: Colleen
authors.initials: C
authors.lastname: Fridley
authors.affiliation: Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Campus box 7362, Chapel Hill, NC, 27599, USA.
authors.forename: Samuel K
authors.initials: SK
authors.lastname: Lai
authors.affiliation: Center for Nanomedicine, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 N Broadway, Baltimore, MD, 21231, USA.|Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD, 21218, USA.|Department of Ophthalmology, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD, 21297, USA.
authors.forename: Laura M
authors.initials: LM
authors.lastname: Ensign
authors.affiliation: Center for Nanomedicine, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 N Broadway, Baltimore, MD, 21231, USA.|Department of Ophthalmology, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD, 21297, USA.
authors.forename: Jung Soo
authors.initials: JS
authors.lastname: Suk
authors.affiliation: Center for Nanomedicine, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 N Broadway, Baltimore, MD, 21231, USA.|Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD, 21205, USA.|Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD, 21218, USA.|Department of Ophthalmology, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD, 21297, USA.
authors.forename: Justin
authors.initials: J
authors.lastname: Hanes
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D009093:Mucus / Q000378:metabolism*; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry*; D012995:Solubility; D013535:Suspensions / Q000008:administration & dosage*
chemical_list: D004364:Pharmaceutical Preparations; D013535:Suspensions
keywords: curcumin; drug delivery; mucus penetrating particles; nanocrystals; nanotechnology