title: Metabolomics, Lipidomics and Pharmacometabolomics of Human Hypertension.
abstract: Hypertension is a common but complex human disease, which can lead to a heart attack, stroke, kidney disease or other complications. Since the pathogenesis of hypertension is heterogeneous and multifactorial, it is crucial to establish a comprehensive metabolomic approach to elucidate the molecular mechanism of hypertension. Although there have been limited metabolomic, lipidomic and pharmacometabolomic studies investigating this disease to date, metabolomic studies on hypertension have provided greater insights into the identification of disease-specific biomarkers, predicting treatment outcome and monitor drug safety and efficacy. Therefore, we discuss recent updates on the applications of metabolomics technology in human hypertension with a focus on metabolic biomarker discovery.
authors.affiliation: Institute of Bioproduct Development and Department of Bioprocess Engineering, Faculty of Chemical Engineering, Universiti Teknologi Malaysia, 81300, Johor, Malaysia. auzlanthony@gmail.com.
authors.forename: Anthony
authors.initials: A
authors.lastname: Au
authors.affiliation: Institute of Bioproduct Development and Department of Bioprocess Engineering, Faculty of Chemical Engineering, Universiti Teknologi Malaysia, 81300, Johor, Malaysia.|Innovation Centre in Agritechnology, Universiti Teknologi Malaysia, 81300, Johor, Malaysia.
authors.forename: Kian-Kai
authors.initials: KK
authors.lastname: Cheng
authors.affiliation: Centre for Biodiversity Research, Universiti Tunku Abdul Rahman, Bandar Barat, 31900, Kampar, Perak, Malaysia.|Department of Biological Science, Faculty of Science, Universiti Tunku Abdul Rahman, Bandar Barat, 31900, Kampar, Perak, Malaysia.
authors.forename: Loo Keat
authors.initials: LK
authors.lastname: Wei
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D008055:Lipids / Q000097:blood*; D055432:Metabolomics / Q000379:methods*; D011237:Predictive Value of Tests; D012307:Risk Factors
chemical_list: D000959:Antihypertensive Agents; D015415:Biomarkers; D008055:Lipids
keywords: Hypertension; Lipidomics; Metabolomics; Pharmacometabolomics