title: Suppression of CD26 inhibits growth and metastasis of pancreatic cancer.
abstract: CD26/DPPIV is a glycosylated transmembrane type II protein and has a multitude of biological functions, while its impact on the malignant phenotypes of cancer cells has not been fully understood. This study aimed to investigate the effect of CD26 on growth and metastasis of pancreatic cancer cells in vitro and in vivo. We found in this study that CD26 expression was higher in cell lines that derived from the metastatic sites than those from the primary tumor sites. In specimens of pancreatic cancer patients, CD26 expression was higher in cancerous tissues than in paired normal tissues. In in vitro experiments, knockdown of CD26 expression inhibited cell growth, migration, invasion, colony formation, and increased cell apoptosis of pancreatic cancer cells. Knockdown of CD26 also decreased tumor growth and liver metastasis in vivo by using xenograft animal models. Suppression of CD26 could inhibit expression of epithelial-mesenchymal transition (EMT) regulatory genes. Our results indicated that CD26 may represent a new therapeutic target for pancreatic cancer.
authors.affiliation: Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Hepato-Pancreato-Biliary Surgery, Peking University Cancer Hospital and Institute, Beijing, People's Republic of China.|Department of Gastroenterological Surgery and Laboratory of Surgical Oncology, Peking University People's Hospital, Beijing, People's Republic of China.
authors.forename: Chunxiang
authors.initials: C
authors.lastname: Ye
authors.affiliation: Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Hepato-Pancreato-Biliary Surgery, Peking University Cancer Hospital and Institute, Beijing, People's Republic of China.
authors.forename: Xiuyun
authors.initials: X
authors.lastname: Tian
authors.affiliation: Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
authors.forename: Guanjun
authors.initials: G
authors.lastname: Yue
authors.affiliation: Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Hepato-Pancreato-Biliary Surgery, Peking University Cancer Hospital and Institute, Beijing, People's Republic of China.
authors.forename: Liang
authors.initials: L
authors.lastname: Yan
authors.affiliation: Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Hepato-Pancreato-Biliary Surgery, Peking University Cancer Hospital and Institute, Beijing, People's Republic of China.
authors.forename: Xiaoya
authors.initials: X
authors.lastname: Guan
authors.affiliation: Department of Gastroenterological Surgery and Laboratory of Surgical Oncology, Peking University People's Hospital, Beijing, People's Republic of China. shanwang60@sina.com.
authors.forename: Shan
authors.initials: S
authors.lastname: Wang
authors.affiliation: Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Hepato-Pancreato-Biliary Surgery, Peking University Cancer Hospital and Institute, Beijing, People's Republic of China. haochunyi@bjmu.edu.cn.
authors.forename: Chunyi
authors.initials: C
authors.lastname: Hao
keywords: CD26; Dipeptidyl peptidase IV; Growth; Metastasis; Pancreatic cancer