title: Long Non-coding RNAs in Urologic Malignancies: Functional Roles and Clinical Translation.
abstract: Early diagnosis and surveillance for metastasis and recurrences are critical issues of urologic cancer. Deregulation of long non-coding RNAs (lncRNAs) has been implicated in urologic malignancies and represents potential markers or therapeutic targets. However, the utility of lncRNA as biomarkers appears to be overstated due to heterogeneous or irreproducible results from different studies. Thus, a critical and cautious review on the biomarker potential of lncRNAs is needed. This review provides an update on new findings of lncRNA-based markers for urologic cancer. The diverse mechanisms and associated examples of lncRNAs involved during the carcinogenesis of prostate cancer, bladder cancer and renal cancer were discussed in a more balanced and critical manner, as were the suitability of lncRNAs as diagnostic or prognostics markers.
authors.affiliation: Center for Systems Biology, Soochow University, Suzhou 215006, China; School of Chemistry, Biological Engineering, Suzhou University of Science and Technology, Suzhou 215011, China.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Chen
authors.affiliation: Center for Systems Biology, Soochow University, Suzhou 215006, China; Suzhou Dushuhu Hospital, Clinic Center, Soochow University, Suzhou 215123, China.
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Miao
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
authors.forename: Boxin
authors.initials: B
authors.lastname: Xue
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
authors.forename: Yuxi
authors.initials: Y
authors.lastname: Shan
authors.affiliation: Ningbo Urologic and Nephrotic Hospital, Ningbo 315000, China.
authors.forename: Guobin
authors.initials: G
authors.lastname: Weng
authors.affiliation: Center for Systems Biology, Soochow University, Suzhou 215006, China.
authors.forename: Bairong
authors.initials: B
authors.lastname: Shen
keywords: lncRNA; long non-coding RNA; marker.; translation; urologic cancer