title: Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation.
abstract: Besides its important role in embryonic development and homeostatic self-renewal in adult tissues, Wnt/β-catenin signaling exerts both anti-inflammatory and proinflammatory functions. This is, at least partially, due to either repressing or enhancing the NF-κB pathway. Similarly, the NF-κB pathway either positively or negatively regulates Wnt/β-catenin signaling. Different components of the two pathways are involved in this crosstalk, forming a complex regulatory network. This review summarizes our current understanding of the molecular mechanisms underlying the cross-regulation between the two pathways and discusses their involvement in inflammation and inflammation-associated diseases such as cancer.
authors.affiliation: School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China; Renji Hospital Clinical Stem Cell Research Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Ma
authors.affiliation: Department of Molecular Mechanisms of Disease, University of Zurich , Zurich , Switzerland.
authors.forename: Michael O
authors.initials: MO
authors.lastname: Hottiger
keywords: NF-κB; Wnt; gene expression; signaling pathways; β-catenin