title: Molecular mechanisms of the anti-obesity effect of bioactive compounds in tea and coffee.
abstract: Obesity is a serious health problem in adults and children worldwide. However, the basic strategies for the management of obesity (diet, exercise, drugs and surgery) have limitations and side effects. Therefore, many researchers have sought to identify bioactive components in food. Tea and coffee are the most frequently consumed beverages in the whole world. Their health benefits have been studied for decades, especially those of green tea. The anti-obesity effect of tea and coffee has been studied for at least ten years. The results have shown decreased lipid accumulation in cells via the regulation of the cell cycle during adipogenesis, changes in transcription factors and lipogenesis-related proteins in the adipose tissue of animal models, and decreased body weight and visceral fat in humans. Tea and coffee also influence the gut microbiota in obese animals and humans. Although the anti-obesity mechanism of tea and coffee still needs further clarification, they may have potential as a new strategy to prevent or treat obesity.
authors.affiliation: Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, Hubei Collaborative Innovation Center for the Characteristic Resources Exploitation of Dabie Mountains, Huanggang Normal University, Huanggang, Hubei, China and Institute of Food Sciences and Technology, National Taiwan University, Taipei 10617, Taiwan. mhpan@ntu.edu.tw emjine@gmail.com and Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan and Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan.
authors.forename: Min-Hsiung
authors.initials: MH
authors.lastname: Pan
authors.affiliation: Institute of Food Sciences and Technology, National Taiwan University, Taipei 10617, Taiwan. mhpan@ntu.edu.tw emjine@gmail.com.
authors.forename: Yen-Chen
authors.initials: YC
authors.lastname: Tung
authors.affiliation: Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, Hubei Collaborative Innovation Center for the Characteristic Resources Exploitation of Dabie Mountains, Huanggang Normal University, Huanggang, Hubei, China.
authors.forename: Guliang
authors.initials: G
authors.lastname: Yang
authors.affiliation: Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, Hubei Collaborative Innovation Center for the Characteristic Resources Exploitation of Dabie Mountains, Huanggang Normal University, Huanggang, Hubei, China.
authors.forename: Shiming
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Food Science, Rutgers University, New Brunswick, NJ 08901, USA.
authors.forename: Chi-Tang
authors.initials: CT
authors.lastname: Ho
mesh_terms: D050156:Adipogenesis / Q000187:drug effects; D000818:Animals; D019440:Anti-Obesity Agents / Q000737:chemistry* / Q000494:pharmacology*; D003069:Coffee / Q000737:chemistry*; D000069196:Gastrointestinal Microbiome / Q000187:drug effects; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects; D013662:Tea / Q000737:chemistry*
chemical_list: D019440:Anti-Obesity Agents; D003069:Coffee; D013662:Tea