title: Human whole genome genotype and transcriptome data for Alzheimer's and other neurodegenerative diseases.
abstract: Previous genome-wide association studies (GWAS), conducted by our group and others, have identified loci that harbor risk variants for neurodegenerative diseases, including Alzheimer's disease (AD). Human disease variants are enriched for polymorphisms that affect gene expression, including some that are known to associate with expression changes in the brain. Postulating that many variants confer risk to neurodegenerative disease via transcriptional regulatory mechanisms, we have analyzed gene expression levels in the brain tissue of subjects with AD and related diseases. Herein, we describe our collective datasets comprised of GWAS data from 2,099 subjects; microarray gene expression data from 773 brain samples, 186 of which also have RNAseq; and an independent cohort of 556 brain samples with RNAseq. We expect that these datasets, which are available to all qualified researchers, will enable investigators to explore and identify transcriptional mechanisms contributing to neurodegenerative diseases.
authors.affiliation: Mayo Clinic, Department of Neuroscience, 4500 San Pablo Road, Jacksonville, Florida 32224, USA.
authors.forename: Mariet
authors.initials: M
authors.lastname: Allen
authors.affiliation: Mayo Clinic, Department of Neuroscience, 4500 San Pablo Road, Jacksonville, Florida 32224, USA.
authors.forename: Minerva M
authors.initials: MM
authors.lastname: Carrasquillo
authors.affiliation: Institute for Systems Biology, 401 Terry Ave N., Seattle, Washington 98109, USA.
authors.forename: Cory
authors.initials: C
authors.lastname: Funk
authors.affiliation: Institute for Systems Biology, 401 Terry Ave N., Seattle, Washington 98109, USA.
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Heavner
authors.affiliation: Mayo Clinic, Department of Neuroscience, 4500 San Pablo Road, Jacksonville, Florida 32224, USA.
authors.forename: Fanggeng
authors.initials: F
authors.lastname: Zou
authors.affiliation: Mayo Clinic, Department of Health Sciences Research, 4500 San Pablo Road, Jacksonville, Florida 32224, USA.
authors.forename: Curtis S
authors.initials: CS
authors.lastname: Younkin
authors.affiliation: Mayo Clinic, Department of Neuroscience, 4500 San Pablo Road, Jacksonville, Florida 32224, USA.
authors.forename: Jeremy D
authors.initials: JD
authors.lastname: Burgess
authors.affiliation: Mayo Clinic, Department of Health Sciences Research, 200 First Street, Rochester, Minnesota 55905, USA.
authors.forename: High-Seng
authors.initials: HS
authors.lastname: Chai
authors.affiliation: Institute for Systems Biology, 401 Terry Ave N., Seattle, Washington 98109, USA.
authors.forename: Julia
authors.initials: J
authors.lastname: Crook
authors.affiliation: Institute for Systems Biology, 401 Terry Ave N., Seattle, Washington 98109, USA.
authors.forename: James A
authors.initials: JA
authors.lastname: Eddy
authors.affiliation: Institute for Systems Biology, 401 Terry Ave N., Seattle, Washington 98109, USA.
authors.forename: Hongdong
authors.initials: H
authors.lastname: Li
authors.affiliation: Sage Bionetworks, 1100 Fairview Ave. N., Seattle, Washington 98109, USA.
authors.forename: Ben
authors.identifier: 0000-0002-0572-2569
authors.initials: B
authors.lastname: Logsdon
authors.affiliation: Sage Bionetworks, 1100 Fairview Ave. N., Seattle, Washington 98109, USA.
authors.forename: Mette A
authors.initials: MA
authors.lastname: Peters
authors.affiliation: Sage Bionetworks, 1100 Fairview Ave. N., Seattle, Washington 98109, USA.
authors.forename: Kristen K
authors.initials: KK
authors.lastname: Dang
authors.affiliation: Mayo Clinic, Department of Health Sciences Research, 4500 San Pablo Road, Jacksonville, Florida 32224, USA.
authors.forename: Xue
authors.initials: X
authors.lastname: Wang
authors.affiliation: Mayo Clinic, Department of Health Sciences Research, 4500 San Pablo Road, Jacksonville, Florida 32224, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Serie
authors.affiliation: Mayo Clinic, Department of Health Sciences Research, 200 First Street, Rochester, Minnesota 55905, USA.
authors.forename: Chen
authors.identifier: 0000-0003-2638-3081
authors.initials: C
authors.lastname: Wang
authors.affiliation: Mayo Clinic, Department of Neuroscience, 4500 San Pablo Road, Jacksonville, Florida 32224, USA.
authors.forename: Thuy
authors.initials: T
authors.lastname: Nguyen
authors.affiliation: Mayo Clinic, Department of Neuroscience, 4500 San Pablo Road, Jacksonville, Florida 32224, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Lincoln
authors.affiliation: Mayo Clinic, Department of Neuroscience, 4500 San Pablo Road, Jacksonville, Florida 32224, USA.
authors.forename: Kimberly
authors.initials: K
authors.lastname: Malphrus
authors.affiliation: Mayo Clinic, Department of Neuroscience, 4500 San Pablo Road, Jacksonville, Florida 32224, USA.
authors.forename: Gina
authors.initials: G
authors.lastname: Bisceglio
authors.affiliation: Mayo Clinic, Department of Neuroscience, 4500 San Pablo Road, Jacksonville, Florida 32224, USA.
authors.forename: Ma
authors.initials: M
authors.lastname: Li
authors.affiliation: University of Florida, Center for Translational Research in Neurodegenerative Diseases, 1275 Center Dr, Gainesville, Florida 32611, USA.
authors.forename: Todd E
authors.initials: TE
authors.lastname: Golde
authors.affiliation: Sage Bionetworks, 1100 Fairview Ave. N., Seattle, Washington 98109, USA.
authors.forename: Lara M
authors.identifier: 0000-0001-7841-3612
authors.initials: LM
authors.lastname: Mangravite
authors.affiliation: Institute for Systems Biology, 401 Terry Ave N., Seattle, Washington 98109, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Asmann
authors.affiliation: Institute for Systems Biology, 401 Terry Ave N., Seattle, Washington 98109, USA.
authors.forename: Nathan D
authors.initials: ND
authors.lastname: Price
authors.affiliation: Mayo Clinic, Department of Neurology, 200 First Street, Rochester, Minnesota 55905, USA.
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Petersen
authors.affiliation: Mayo Clinic, Department of Neurology, 4500 San Pablo Road, Jacksonville, Florida 32224, USA.
authors.forename: Neill R
authors.initials: NR
authors.lastname: Graff-Radford
authors.affiliation: Mayo Clinic, Department of Neuroscience, 4500 San Pablo Road, Jacksonville, Florida 32224, USA.
authors.forename: Dennis W
authors.initials: DW
authors.lastname: Dickson
authors.affiliation: Mayo Clinic, Department of Neuroscience, 4500 San Pablo Road, Jacksonville, Florida 32224, USA.
authors.forename: Steven G
authors.initials: SG
authors.lastname: Younkin
authors.affiliation: Mayo Clinic, Department of Neuroscience, 4500 San Pablo Road, Jacksonville, Florida 32224, USA.|Mayo Clinic, Department of Neurology, 4500 San Pablo Road, Jacksonville, Florida 32224, USA.
authors.forename: Nilüfer
authors.initials: N
authors.lastname: Ertekin-Taner
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D015894:Genome, Human; D055106:Genome-Wide Association Study; D006801:Humans; D019636:Neurodegenerative Diseases / Q000235:genetics*; D059467:Transcriptome