title: Comparison of Nanoemulsion and Aqueous Micelle Systems of Paliperidone for Intranasal Delivery.
abstract: The objective of the study was to develop and compare the efficiency of nanoemulsion and aqueous micelle system of Paliperidone on intranasal administration. Both the formulations were evaluated for physical parameters such as globule size, pH, viscosity, conductivity and in vitro drug release studies. The reduction in spontaneous motor activity of L-dopa and Carbidopa-treated Swiss Albino mice on intranasal administration of nanoemulsion and micellar system of Paliperidone was compared with plain drug suspension. Histopathological evaluation of formulation treated nasal mucosal membrane was performed. Nasal spray device was evaluated for spray pattern and volume per actuation. Globule size of micellar system and nanoemulsion was found to be 16.14 & 38.25 nm, respectively. In vitro release of drug from micellar system was found to be 1.8-fold higher than nanoemulsion. The loading of drug in nanoemulsion was found to be superior (2.5 mg/mL) when compared to micellar system (0.41 mg/mL). The spray pattern of micellar system and nanoemulsion from the device was elliptical and circular, respectively. The locomotor activity of L-dopa and Carbidopa-treated Swiss albino mice was found to be 1096.5±78.49, 551.5±13.43 and 535.5±24.75 counts/min in case of plain drug suspension, micellar system and nanoemulsion, respectively. The intranasal administration of developed formulations showed significant difference (p<0.01) in the locomotor activity when compared to intranasal administration of plain drug. Thus it can be concluded that both the developed formulations have shown improved in vivo activity on intranasal administration and pose great potential for delivery of Paliperidone through intranasal route.
authors.affiliation: Department of Pharmaceutics, SVKM's NMIMS Deemed-to-be-University, Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, 5th Floor, Mithibai building, V.L. Mehta Road, Vile Parle (w), Mumbai, 400056, India.
authors.forename: Kartika
authors.initials: K
authors.lastname: Pidaparthi
authors.affiliation: Department of Pharmaceutics, SVKM's NMIMS Deemed-to-be-University, Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, 5th Floor, Mithibai building, V.L. Mehta Road, Vile Parle (w), Mumbai, 400056, India. divyasuares@gmail.com.
authors.forename: Divya
authors.initials: D
authors.lastname: Suares
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D002230:Carbidopa / Q000494:pharmacology; D016503:Drug Delivery Systems; D004655:Emulsions; D007980:Levodopa / Q000494:pharmacology; D051379:Mice; D008823:Micelles; D009043:Motor Activity / Q000187:drug effects; D053758:Nanoparticles; D000068882:Paliperidone Palmitate / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D004655:Emulsions; D008823:Micelles; D007980:Levodopa; D002230:Carbidopa; D000068882:Paliperidone Palmitate
keywords: intranasal; micelle systems; nanoemulsion; paliperidone; spontaneous motor activity