title: Computation-guided improved one-pot synthesis of macrocyclic cation-binding aromatic pyridone pentamers.
abstract: By using polar DMF to relax the H-bonded rigid backbone and to lower the energetic penalty associated with the sterically-crowded environment, the yields for BOP-mediated one-pot synthesis of pentameric macrocycles can be improved from 10-25% as obtained in CH2Cl2to 13-47% when 15% DMF in CH2Cl2was used as the reaction medium.
authors.affiliation: Singapore American School, 40 Woodlands Street 41, 738547 Singapore.
authors.forename: Vicky Ziman
authors.initials: VZ
authors.lastname: Zeng
authors.affiliation: Division of Materials Science, 50 Nanyang Avenue, Nanyang Technological University, 639798, Singapore.
authors.forename: Haibin
authors.initials: H
authors.lastname: Su
authors.affiliation: Division of Chemistry and Biological Chemistry, 21 Nanyang Link, Nanyang Technological University, 637371 Singapore. thli@ntu.edu.sg.
authors.forename: Tianhu
authors.initials: T
authors.lastname: Li