title: Impact of glucose tolerance status on the development of coronary artery disease among working-age men.
abstract: OBJECTIVE
  To examine the impact of glucose tolerance status on the development of coronary artery disease (CAD) in working-age men in Japan.
  
  
  METHODS
  This population-based retrospective cohort study included 111,621 men aged 31-60 years [63,558 with normal glucose tolerance (NGT); 37,126 with prediabetes; 10,937 with diabetes]. The Cox proportional-hazards regression model was used to identify variables related to the incidence of CAD.
  
  
  RESULTS
  Multivariate analysis showed that, compared with NGT, diabetes increased the risk of CAD by 17.3 times (95% CI: 6.36-47.0) at ages 31-40 years, by 2.74 times (95% CI: 1.85-4.05) at ages 41-50 years and by 2.47 times (95% CI: 1.69-3.59) at ages 51-60 years. The HRs for CAD in men with diabetes aged 31-40 equaled that of men with NGT aged 51-60 [18.2 (7.15-46.4) and 19.4 (8.28-45.4), respectively].
  
  
  CONCLUSIONS
  The impact of diabetes on CAD was markedly greater in men aged 31-40 years compared with those aged 41-60 years.
authors.affiliation: Department of Internal Medicine, Niigata University Faculty of Medicine, Niigata, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Fujihara
authors.affiliation: Department of Internal Medicine, Niigata University Faculty of Medicine, Niigata, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Igarashi
authors.affiliation: Department of Internal Medicine, Niigata University Faculty of Medicine, Niigata, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
authors.affiliation: Japan Medical Data Center Co., Ltd., Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ishizawa
authors.affiliation: Department of Internal Medicine, Niigata University Faculty of Medicine, Niigata, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Matsubayasi
authors.affiliation: Department of Internal Medicine, Niigata University Faculty of Medicine, Niigata, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Matsunaga
authors.affiliation: Department of Internal Medicine, Niigata University Faculty of Medicine, Niigata, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kato
authors.affiliation: Japan Medical Data Center Co., Ltd., Tokyo, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Ito
authors.affiliation: Japan Medical Data Center Co., Ltd., Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Koishi
authors.affiliation: Japan Medical Data Center Co., Ltd., Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Yamanaka
authors.affiliation: Department of Internal Medicine, Niigata University Faculty of Medicine, Niigata, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kodama
authors.affiliation: Department of Internal Medicine, Niigata University Faculty of Medicine, Niigata, Japan. Electronic address: sone@med.niigata-u.ac.jp.
authors.forename: H
authors.initials: H
authors.lastname: Sone
mesh_terms: D000328:Adult; D001786:Blood Glucose; D003324:Coronary Artery Disease / Q000150:complications* / Q000453:epidemiology*; D003924:Diabetes Mellitus, Type 2; D018149:Glucose Intolerance / Q000150:complications* / Q000453:epidemiology*; D005951:Glucose Tolerance Test; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State; D012189:Retrospective Studies
chemical_list: D001786:Blood Glucose
keywords: Coronary artery disease; Glucose tolerance status; Working-age men