title: Plasmonic Metasurfaces Based on Nanopin-Cavity Resonator for Quantitative Colorimetric Ricin Sensing.
abstract: In view of the toxic potential of a bioweapon threat, rapid visual recognition and sensing of ricin has been of considerable interest while remaining a challenging task up to date. In this study, a gold nanopin-based colorimetric sensor is developed realizing a multicolor variation for ricin qualitative recognition and analysis. It is revealed that such plasmonic metasurfaces based on nanopin-cavity resonator exhibit reflective color appearance, due to the excitation of standing-wave resonances of narrow bandwidth in visible region. This clear color variation is a consequence of the reflective color mixing defined by different resonant wavelengths. In addition, the colored metasurfaces appear sharp color difference in a narrow refractive index range, which makes them especially well-suited for sensing applications. Therefore, this antibody-functionalized nanopin-cavity biosensor features high sensitivity and fast response, allowing for visual quantitative ricin detection within the range of 10-120 ng mL-1(0.15 × 10-9-1.8 × 10-9m), a limit of detection of 10 ng mL-1, and the typical measurement time of less than 10 min. The on-chip integration of such nanopin metasurfaces to portable colorimetric microfluidic device may be envisaged for the quantitative studies of a variety of biochemical molecules.
authors.affiliation: National Key Laboratory of Science and Technology on Micro/Nano Fabrication, Institute of Microelectronics, Peking University, Beijing, 100871, P. R. China.|Innovation Center for MicroNanoelectronics and Integrated System, Beijing, 100871, P. R. China.
authors.forename: Jiao-Rong
authors.initials: JR
authors.lastname: Fan
authors.affiliation: National Key Laboratory of Science and Technology on Micro/Nano Fabrication, Institute of Microelectronics, Peking University, Beijing, 100871, P. R. China.|Innovation Center for MicroNanoelectronics and Integrated System, Beijing, 100871, P. R. China.
authors.forename: Jia
authors.initials: J
authors.lastname: Zhu
authors.affiliation: National Key Laboratory of Science and Technology on Micro/Nano Fabrication, Institute of Microelectronics, Peking University, Beijing, 100871, P. R. China.|Innovation Center for MicroNanoelectronics and Integrated System, Beijing, 100871, P. R. China.
authors.forename: Wen-Gang
authors.initials: WG
authors.lastname: Wu
authors.affiliation: National Key Laboratory of Science and Technology on Micro/Nano Fabrication, Institute of Microelectronics, Peking University, Beijing, 100871, P. R. China.|Innovation Center for MicroNanoelectronics and Integrated System, Beijing, 100871, P. R. China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Huang
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D003116:Color; D003124:Colorimetry / Q000295:instrumentation*; D003198:Computer Simulation; D007700:Kinetics; D053758:Nanoparticles / Q000737:chemistry*; D012031:Refractometry; D012276:Ricin / Q000032:analysis*; D020349:Surface Plasmon Resonance / Q000295:instrumentation*; D013499:Surface Properties; D013997:Time Factors
chemical_list: D012276:Ricin
keywords: colorimetric sensors; gold nanopins; multicolor variation; ricin; surface plasmon