title: The Risk for Insulin Resistance according to the Degree of Non-Alcoholic Fatty Liver Disease in Korean Men.
abstract: Insulin resistance (IR) plays a significant role in the development and progression of non-alcoholic fatty liver disease (NAFLD). However, the natural course of insulin sensitivity under NAFLD remained unclear. Accordingly, this study was designed to investigate the effect of NAFLD on insulin resistance. A total of 20,628 Korean men without homeostasis model assessment of insulin resistance (HOMA-IR < 2.7) were followed-up for 5 years. They were serially checked for HOMA-IR to monitor the development of IR (HOMA-IR ≥ 2.7). The incidence rate of IR increased according to the degree of NAFLD (normal: 11.6%, mild: 28.8%, moderate to severe: 40.5%, P < 0.001). Cox proportional hazards model showed that HRs (95% CI) for IR increased proportionally to the degree of NAFLD (mild: 1.19 [1.02-1.39], moderate to severe: 1.32 [1.08-1.57]). IR was more potentially associated with the more progressive NAFLD than normal and milder state. In addition, NAFLD was the independent risk factor of the development of IR. These results suggest the potential availability of NAFLD as a predictor of IR.
authors.affiliation: Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Jae Hong
authors.identifier: http://orcid.org/0000-0002-5232-1426
authors.initials: JH
authors.lastname: Ryoo
authors.affiliation: Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Hyun Pyo
authors.identifier: http://orcid.org/0000-0003-1451-3141
authors.initials: HP
authors.lastname: Hong
authors.affiliation: Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. kkkmin7@hotmail.com.
authors.forename: Sung Keun
authors.identifier: http://orcid.org/0000-0003-4703-9917
authors.initials: SK
authors.lastname: Park
authors.affiliation: Department of Physical Education, Graduate School, Sangji University, Wonju, Korea.
authors.forename: Woo Taek
authors.identifier: http://orcid.org/0000-0003-3212-1627
authors.initials: WT
authors.lastname: Ham
authors.affiliation: Department of Industrial Design, Chonbuk National University, College of Arts, Jeonju, Korea.
authors.forename: Ju Youn
authors.initials: JY
authors.lastname: Chung
mesh_terms: D000005:Abdomen / Q000000981:diagnostic imaging; D000328:Adult; D044466:Asian People; D015444:Exercise; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications; D015994:Incidence; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D016016:Proportional Hazards Models; D056910:Republic of Korea; D012307:Risk Factors; D012720:Severity of Illness Index; D012907:Smoking; D011795:Surveys and Questionnaires; D014463:Ultrasonography
keywords: HOMA-IR; HOMA-ß; Insulin Resistance; Non-Alcoholic Fatty Liver Disease