title: Evaluation of the management of pregnancies and infants at risk for congenital syphilis: La Réunion, 2008 to 2014.
abstract: To evaluate the maternal-fetal management and follow-up of infants at risk for congenital syphilis.
  
  
  
  Monocentric retrospective cohort study at the Félix Guyon Hospital, Saint-Denis, La Réunion between January 2008 and December 2014. Management of 38 pregnancies (35 women, 39 fetuses) with a positive syphilis serology was evaluated according to the Centers for Disease Control and Prevention (CDC) guidelines.
  
  
  
  A total of 68% (n=26) of pregnancies were screened before 16 weeks of gestation, and 26% (n=10) had appropriate treatment. Adverse outcomes were noted in 45% of pregnancies. Neonatal serology was not performed in 7 live-born neonates (19%) and 33 infants were classifiable according to the four CDC scenarios. In the infants, adequate complementary evaluation and appropriate treatment were noted in 42% (n=13) and 55% (n=17) of cases, respectively. Rate of infant follow-up was 76% (n=16). No treatment failure was observed in infants.
  
  
  
  Reinforcement of public health policies and a better sensitization, training and collaboration among perinatal caregivers are warranted given the gaps revealed in our study.
authors.affiliation: Neonatal and Pediatric Intensive Care Unit, Félix Guyon Hospital, CHU de La Réunion, La Réunion, France.
authors.forename: M
authors.initials: M
authors.lastname: Le Chevalier de Préville
authors.affiliation: Neonatal and Pediatric Intensive Care Unit, Félix Guyon Hospital, CHU de La Réunion, La Réunion, France.
authors.forename: J-L
authors.initials: JL
authors.lastname: Alessandri
authors.affiliation: Microbiology/Virology Laboratory, Félix Guyon Hospital, CHU de La Réunion, La Réunion, France.
authors.forename: N
authors.initials: N
authors.lastname: Traversier
authors.affiliation: Department of Obstetrics and Gynecology, Félix Guyon Hospital, CHU de La Réunion, La Réunion, France.
authors.forename: F
authors.initials: F
authors.lastname: Cuillier
authors.affiliation: Department of Pediatrics, Félix Guyon Hospital, CHU de La Réunion, La Réunion, France.
authors.forename: S
authors.initials: S
authors.lastname: Robin
authors.affiliation: Neonatal and Pediatric Intensive Care Unit, Félix Guyon Hospital, CHU de La Réunion, La Réunion, France.
authors.forename: D
authors.initials: D
authors.lastname: Ramful
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005602:France; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010400:Penicillin G / Q000627:therapeutic use*; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors; D013590:Syphilis, Congenital / Q000175:diagnosis* / Q000188:drug therapy* / Q000517:prevention & control; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D010400:Penicillin G