title: Copper-Mediated Radiofluorination of Arylstannanes with [18F]KF.
abstract: A copper-mediated nucleophilic radiofluorination of aryl- and vinylstannanes with [18F]KF is described. This method is fast, uses commercially available reagents, and is compatible with both electron-rich and electron-deficient arene substrates. This method has been applied to the manual synthesis of a variety of clinically relevant radiotracers including protected [18F]F-phenylalanine and [18F]F-DOPA. In addition, an automated synthesis of [18F]MPPF is demonstrated that delivers a clinically validated dose of 200 ± 20 mCi with a high specific activity of 2400 ± 900 Ci/mmol.
authors.forename: Katarina J
authors.initials: KJ
authors.lastname: Makaravage
authors.affiliation: Department of Radiology, University of Michigan Medical School , 1301 Catherine Street, Ann Arbor, Michigan 48109, United States.
authors.forename: Allen F
authors.initials: AF
authors.lastname: Brooks
authors.affiliation: Department of Radiology, University of Michigan Medical School , 1301 Catherine Street, Ann Arbor, Michigan 48109, United States.
authors.forename: Andrew V
authors.initials: AV
authors.lastname: Mossine
authors.forename: Melanie S
authors.initials: MS
authors.lastname: Sanford
authors.affiliation: Department of Radiology, University of Michigan Medical School , 1301 Catherine Street, Ann Arbor, Michigan 48109, United States.
authors.forename: Peter J H
authors.initials: PJH
authors.lastname: Scott