title: Diabetic Osteoporosis: A Review of Its Traditional Chinese Medicinal Use and Clinical and Preclinical Research.
abstract: Aim. The incidence of diabetic osteoporosis (DOP) is increasing due to lack of effective management over the past few decades. This review aims to summarize traditional Chinese medicine (TCM) suitability in the pathogenesis and clinical and preclinical management of DOP.Methods. Literature sources used were from Medline (Pubmed), CNKI (China Knowledge Resource Integrated Database), and CSTJ (China Science and Technology Journal Database) online databases. For the consultation, keywords such as diabetic osteoporosis (DOP), TCM, clinical study, animal experiment, toxicity, and research progress were used in various combinations. Around 100 research papers and reviews were visited.Results. Liver-spleen-kidney insufficiency may result in development of DOP. 18 clinical trials are identified to use TCM compound prescriptions for management of patients with DOP. TCM herbs and their active ingredients are effective in preventing the development of DOP in streptozotocin (STZ) and alloxan as well as STZ combined with ovariectomy insulted rats. Among them, most frequently used TCM herbs in clinical trials are RadixAstragali, Radix et RhizomaSalviae Miltiorrhizae, RadixRehmanniae Preparata, and HerbaEpimedii. Some of TCM herbs also exhibit toxicities in clinical and preclinical research.Conclusions. TCM herbs may act as the novel sources of anti-DOP drugs by improving bone and glucolipid metabolisms. However, the pathogenesis of DOP and the material base of TCM herbs still merit further study.
authors.affiliation: Preclinical Medicine School, Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Rufeng
authors.initials: R
authors.lastname: Ma
authors.affiliation: Preclinical Medicine School, Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Ruyuan
authors.initials: R
authors.lastname: Zhu
authors.affiliation: Preclinical Medicine School, Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Wang
authors.affiliation: Preclinical Medicine School, Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Yubo
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Chinese Materia Medica School, Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Chenyue
authors.initials: C
authors.lastname: Liu
authors.affiliation: Preclinical Medicine School, Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Haixia
authors.initials: H
authors.lastname: Liu
authors.affiliation: Henan Luoyang Orthopedic Traumatological Hospital, Luoyang 471000, China.
authors.forename: Fengwei
authors.initials: F
authors.lastname: Liu
authors.affiliation: Henan Luoyang Orthopedic Traumatological Hospital, Luoyang 471000, China.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Li
authors.affiliation: Preclinical Medicine School, Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Li
authors.affiliation: The Research Institute of McGill University Health Center, Montreal, QC, Canada H4A 3J1.
authors.forename: Min
authors.initials: M
authors.lastname: Fu
authors.affiliation: Diabetes Research Center, Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Dongwei
authors.identifier: 0000-0002-7793-1482
authors.initials: D
authors.lastname: Zhang