title: GSTT1Null Genotype Significantly Increases the Susceptibility to Urinary System Cancer: Evidences from 63,876 Subjects.
abstract: GSTT1gene plays an important role in detoxification and clearance of reactive oxygen species(ROS). A null variant in this gene has been demonstrated to confer cancer susceptibility. Although many studies have demonstrated the association betweenGSTT1null polymorphism and urinary system cancer susceptibility, several publications reported opposite conclusions. For better understanding the effects of this polymorphism on the risk of urinary system cancer, a updated meta-analysis was performed with a total of 26,666 cases and 37,210 controls extracted from 117 studies, by following the latest meta-analysis guidelines (PRISMA). The results suggested that theGSTT1null genotype was significantly associated with an increased risk of urinary system cancer (OR=1.13, 95%CI=1.05-1.22). Furthermore, stratified analyses by the type of cancer, ethnicity, source of control and quality score presented a significantly increased risk associated withGSTT1null genotype in bladder and prostate cancer subgroup, Caucasians and Indians subgroup, population-based(PB) subgroup, medium quality and low quality subgroup. Overall, our meta-analysis suggested thatGSTT1null genotype is a potential cancer susceptibility variant. Well-designed and large-cohort studies are needed to confirm the association betweenGSTT1null genotype and urinary system cancer risk.
authors.affiliation: Department of Cardiovascular Surgery of the First Affiliated Hospital& Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Department of Experimental Research, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, Guangdong, China.; Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China.
authors.forename: Jing
authors.initials: J
authors.lastname: He
authors.affiliation: Department of Internal Medicine, Harbin Medical University, Harbin 150081, Heilongjiang, China.
authors.forename: Tian-Jiao
authors.initials: TJ
authors.lastname: Ma
authors.affiliation: Department of Cardiovascular Surgery of the First Affiliated Hospital& Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Lei
authors.affiliation: Department of Urinary Surgery, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Cardiovascular Surgery of the First Affiliated Hospital& Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu, China.
authors.forename: Han
authors.initials: H
authors.lastname: Shen
authors.affiliation: Department of Cardiovascular Surgery of the First Affiliated Hospital& Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu, China.
authors.forename: Zhen-Ya
authors.initials: ZY
authors.lastname: Shen
keywords: GSTT1; meta-analysis; oxidative stress; polymorphism; susceptibility; urinary system cancer