title: Association of the melanocortin 4 receptor gene rs17782313 polymorphism with rewarding value of food and eating behavior in Chilean children.
abstract: Studies conducted in monozygotic and dizygotic twins have established a strong genetic component in eating behavior. Rare mutations and common variants of the melanocortin 4 receptor (MC4R) gene have been linked to obesity and eating behavior scores. However, few studies have assessed common variants in MC4R gene with the rewarding value of food in children. The objective of the study was to evaluate the association between the MC4R rs17782313 polymorphism with homeostatic and non-homeostatic eating behavior patterns in Chileans children. This is a cross-sectional study in 258 Chilean children (44 % female, 8-14 years old) showing a wide variation in BMI. Anthropometric measurements (weight, height, Z-score of BMI and waist circumference) were performed by standard procedures. Eating behavior was assessed using the Eating in Absence of Hunger Questionnaire (EAHQ), the Child Eating Behavior Questionnaire (CEBQ), the Three-Factor Eating Questionnaire (TFEQ), and the Food Reinforcement Value Questionnaire (FRVQ). Genotype of the rs17782313 nearby MC4R was determined by a Taqman assay. Association of the rs17782313 C allele with eating behavior was assessed using non-parametric tests. We found that children carrying the CC genotype have higher scores of food responsiveness (p value = 0.02). In obese girls, carriers of the C allele showed lower scores of satiety responsiveness (p value = 0.02) and higher scores of uncontrolled eating (p value = 0.01). Obese boys carrying the C allele showed lower rewarding value of food in relation to non-carriers. The rs17782313 C allele is associated with eating behavior traits that may predispose obese children to increased energy intake and obesity.
authors.affiliation: Escuela de Nutrición y dietética. Facultad de Ciencias de la Salud, Universidad San Sebastián, Campus Las Tres Pascualas Lientur 1457, Código Postal 4080871, Concepción, Chile. aniobregon@gmail.com.
authors.forename: A M
authors.initials: AM
authors.lastname: Obregón
authors.affiliation: Escuela de Nutrición y dietética. Facultad de Ciencias de la Salud, Universidad San Sebastián, Campus Las Tres Pascualas Lientur 1457, Código Postal 4080871, Concepción, Chile.
authors.forename: K
authors.initials: K
authors.lastname: Oyarce
authors.affiliation: Departamento de Nutrición, Diabetes y Metabolismo, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: J L
authors.initials: JL
authors.lastname: Santos
authors.affiliation: Departamento de Ciencias Químicas y Biológicas, Universidad Bernardo O Higgins, Santiago, Chile.
authors.forename: M
authors.initials: M
authors.lastname: Valladares
authors.affiliation: Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada.
authors.forename: G
authors.initials: G
authors.lastname: Goldfield
mesh_terms: D020413:3' Untranslated Regions; D000293:Adolescent; D000483:Alleles; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D002677:Chile; D003430:Cross-Sectional Studies; D005247:Feeding Behavior; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D006963:Hyperphagia / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D050177:Overweight / Q000209:etiology*; D063766:Pediatric Obesity / Q000209:etiology*; D011110:Polymorphism, Genetic; D044105:Receptor, Melanocortin, Type 4 / Q000235:genetics* / Q000378:metabolism; D012054:Reinforcement, Psychology; D012201:Reward; D055105:Waist Circumference
chemical_list: D020413:3' Untranslated Regions; C470072:MC4R protein, human; D044105:Receptor, Melanocortin, Type 4
keywords: Children; Eating behavior; Melanocortin 4 receptor gene; Polymorphism