title: [The results of combined surgical treatment of thromboangiitis obliterans and critical lower limb ischemia using prolonged epidural analgesia and autohemotherapy with ozone].
abstract: OBJECTIVE
  to evaluate the results of combined treatment of thromboangiitis obliterans with severe lower limb ischemia using prolonged epidural anaesthesia and autohemotherapy with ozone.
  
  
  METHODS
  It was analyzed treatment of 125 patients with thromboangiitis obliterans and severe lower limb ischemia. Patients were divided into 2 groups. Control group consisted of 60 patients who underwent conventional perioperative therapy with anticoagulants, antiplatelet agents, dextrans, metabolic drugs, glucocorticoids, angioprotectors, narcotic and non-narcotic analgesics. Study group included 65 patients in whom prolonged epidural anaesthesia and autohemotherapy with ozone was applied additionally.
  
  
  RESULTS
  In early postoperative period (up to 30 days) the incidence of secondary lower leg amputation was 10% and 1.5% in both groups respectively (p<0.05). Primary healing after limited foot amputation was achieved in 63.6% and 83.3% in control and stugy groups respectively (p<0.05). Ulcerative defect recovery was observed in 62.2% and 76.2% in both groups respectively (p<0.01). Satisfactory result of treatment was obtained in 61.7% and 80.0% of patients.
  
  
  CONCLUSIONS
  Restoration of magistral and collateral blood flow combined with prolonged epidural anaesthesia and autohemotherapy with ozone improves surgical outcomes and rehabilitation of patients with thromboangiitis obliterans and severe lower limb ischemia.
authors.affiliation: Sechenov First Moscow State Medical University, Moscow.
authors.forename: N S
authors.initials: NS
authors.lastname: Abyshov
authors.affiliation: Topchibashev Research Ceneter of Surgery, Baku, Azerbaijan.
authors.forename: A G
authors.initials: AG
authors.lastname: Abdullayev
authors.affiliation: Topchibashev Research Ceneter of Surgery, Baku, Azerbaijan.
authors.forename: E D
authors.initials: ED
authors.lastname: Zakirdzhaev
authors.affiliation: Topchibashev Research Ceneter of Surgery, Baku, Azerbaijan.
authors.forename: R A
authors.initials: RA
authors.lastname: Guliyev
authors.affiliation: Topchibashev Research Ceneter of Surgery, Baku, Azerbaijan.
authors.forename: M B
authors.initials: MB
authors.lastname: Akhmedov
authors.affiliation: Topchibashev Research Ceneter of Surgery, Baku, Azerbaijan.
authors.forename: G T
authors.initials: GT
authors.lastname: Tagizade
authors.affiliation: Topchibashev Research Ceneter of Surgery, Baku, Azerbaijan.
authors.forename: G M
authors.initials: GM
authors.lastname: Zeynalova
authors.affiliation: Topchibashev Research Ceneter of Surgery, Baku, Azerbaijan.
authors.forename: L D
authors.initials: LD
authors.lastname: Mamedova
mesh_terms: D000328:Adult; D000671:Amputation, Surgical / Q000009:adverse effects / Q000379:methods; D015360:Analgesia, Epidural / Q000379:methods*; D001382:Azerbaijan; D003131:Combined Modality Therapy / Q000379:methods; D005260:Female; D006801:Humans; D007511:Ischemia / Q000175:diagnosis / Q000209:etiology; D035002:Lower Extremity / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D010083:Oxidants, Photochemical / Q000627:therapeutic use; D010126:Ozone / Q000627:therapeutic use*; D019990:Perioperative Care / Q000379:methods; D012720:Severity of Illness Index; D013919:Thromboangiitis Obliterans / Q000150:complications / Q000175:diagnosis / Q000601:surgery; D016896:Treatment Outcome; D058017:Vascular Grafting / Q000009:adverse effects / Q000379:methods; D014945:Wound Healing
chemical_list: D010083:Oxidants, Photochemical; D010126:Ozone