title: Biological factor related to Asian sand dust particles contributes to the exacerbation of asthma.
abstract: Epidemiologic studies have revealed that Asian sand dust particles (ASDs) can affect respiratory and immune health represented by asthma. Factors responsible for the exacerbation of asthma remain unclear. The fungus Bjerkandera adusta (B.ad) and polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP) have been identified in ASDs collected from the atmosphere when an ASD event occurred. We investigated the effects of B.ad and BaP related to ASDs on respiratory and immune systems. Bone marrow-derived antigen-presenting cells (APCs) and splenocytes from atopic prone NC/Nga mice and human airway epithelial cells were exposed to the B.ad or to BaP in the presence and absence of heated-ASDs (H-ASDs). B.ad and BaP in both the presence and absence of H-ASDs increased the expression of cell surface molecules on APCs. H-ASDs alone slightly activated APCs. The expressions induced by B.ad were higher than those induced by BaP in the presence and absence of H-ASDs. There were no remarkable effects on the activation of splenocytes or the proinflammatory responses in airway epithelial cells. These results suggest that B.ad rather than BaP contributes to the exacerbation of asthma regardless of the presence or absence of sand particles, particularly by the activation of the immune system via APCs. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Environmental Health Division, Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Honda
authors.affiliation: Environmental Health Division, Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Sawahara
authors.affiliation: Environmental Health Division, Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Hayashi
authors.affiliation: Environmental Health Division, Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
authors.forename: Kenshi
authors.initials: K
authors.lastname: Tsuji
authors.affiliation: Environmental Health Division, Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Fukushima
authors.affiliation: Environmental Health Division, Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
authors.forename: Mizuki
authors.initials: M
authors.lastname: Oishi
authors.affiliation: Environmental Health Division, Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
authors.forename: Gaku
authors.initials: G
authors.lastname: Kitamura
authors.affiliation: Environmental Health Division, Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
authors.forename: Hitomi
authors.initials: H
authors.lastname: Kudo
authors.affiliation: Environmental Health Division, Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
authors.forename: Sho
authors.initials: S
authors.lastname: Ito
authors.affiliation: Department of Health Sciences, Oita University of Nursing and Health Sciences, Oita, Japan.
authors.forename: Seiichi
authors.initials: S
authors.lastname: Yoshida
authors.affiliation: Department of Health Sciences, Oita University of Nursing and Health Sciences, Oita, Japan.
authors.forename: Takamichi
authors.initials: T
authors.lastname: Ichinose
authors.affiliation: Environmental Health Division, Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
authors.forename: Kayo
authors.initials: K
authors.lastname: Ueda
authors.affiliation: Environmental Health Division, Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Takano
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000187:drug effects; D001208:Asia; D001249:Asthma / Q000503:physiopathology*; D001564:Benzo(a)pyrene / Q000633:toxicity; D049109:Cell Proliferation / Q000187:drug effects; D055453:Coriolaceae / Q000737:chemistry; D016207:Cytokines / Q000096:biosynthesis; D004391:Dust; D004847:Epithelial Cells / Q000187:drug effects; D006801:Humans; D008297:Male; D051379:Mice; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity; D012822:Silicon Dioxide / Q000633:toxicity*; D013154:Spleen / Q000187:drug effects / Q000276:immunology
chemical_list: D016207:Cytokines; D004391:Dust; D011084:Polycyclic Aromatic Hydrocarbons; D001564:Benzo(a)pyrene; D012822:Silicon Dioxide
keywords: Asian sand dust particles; Bjerkandera adusta; asthma; benzo(a)pyrene; bone-marrow-derived antigen presenting cells