title: Epidemiology of Parkinson Disease.
abstract: Parkinson disease (PD) is a common progressive neurodegenerative condition, causing both motor and non motor symptoms. Motor symptoms include stiffness, slowness, rest tremor and poor postural reflexes, whereas nonmotor symptoms include abnormalities of mood, cognition, sleep and autonomic function. Affected patients show cell loss in the substantia nigra pars compacta, and accumulation of aggregated alpha-synuclein into intracellular structures called Lewy bodies, within specific brain regions. The main known non modifiable risk factor is age. The neuroepidemiology of PD is complex with susceptibility genes and a number of modifiable risk factors that can increase and others that can mitigate risk and outcome.
authors.affiliation: Department of Neurology, New York University School of Medicine, 240 East 38th Street, 20th Floor, New York, NY 10016, USA.
authors.forename: Andrea
authors.initials: A
authors.lastname: Lee
authors.affiliation: Department of Neurology, New York University School of Medicine, 240 East 38th Street, 20th Floor, New York, NY 10016, USA; The Marlene and Paolo Fresco Institute for Parkinson's and Movement Disorders, New York University Langone Medical Center, 240 East 38th Street, 20th Floor, New York, NY 10016, USA. Electronic address: Rebecca.Gilbert2@nyumc.org.
authors.forename: Rebecca M
authors.initials: RM
authors.lastname: Gilbert
mesh_terms: D006801:Humans; D010300:Parkinson Disease / Q000453:epidemiology* / Q000235:genetics / Q000628:therapy; D011634:Public Health
keywords: Epidemiology; Neurodegenerative disorder; Neuroepidemiology; Parkinson disease