title: Rho GTPases operating at the Golgi complex: Implications for membrane traffic and cancer biology.
abstract: The Golgi complex is the central unit of the secretory pathway, modifying, processing and sorting proteins and lipids to their correct cellular localisation. Changes to proteins at the Golgi complex can have deleterious effects on the function of this organelle, impeding trafficking routes through it, potentially resulting in disease. It is emerging that several Rho GTPase proteins, namely Cdc42, RhoBTB3, RhoA and RhoD are at least in part localised to the Golgi complex, and a number of studies have shown that dysregulation of their levels or activity can be associated with cellular changes which ultimately drive cancer progression. In this mini-review we highlight some of the recent work that explores links between form and function of the Golgi complex, Rho GTPases and cancer.
authors.affiliation: School of Biology & Environmental Science and Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Dublin 4, Ireland.
authors.forename: Maeve
authors.initials: M
authors.lastname: Long
authors.affiliation: School of Biology & Environmental Science and Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Dublin 4, Ireland. Electronic address: jeremy.simpson@ucd.ie.
authors.forename: Jeremy C
authors.initials: JC
authors.lastname: Simpson
mesh_terms: D006056:Golgi Apparatus / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D021381:Protein Transport / Q000235:genetics; D020764:cdc42 GTP-Binding Protein / Q000235:genetics; D020741:rho GTP-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D020742:rhoA GTP-Binding Protein / Q000235:genetics
chemical_list: D008565:Membrane Proteins; C066737:RHOA protein, human; C105243:RHOD protein, human; C541346:RhoBTB3 protein, human; D020764:cdc42 GTP-Binding Protein; D020741:rho GTP-Binding Proteins; D020742:rhoA GTP-Binding Protein
keywords: Cancer; Golgi complex; Membrane trafficking; Rho GTPase proteins