title: Morbillivirus Experimental Animal Models: Measles Virus Pathogenesis Insights from Canine Distemper Virus.
abstract: Morbilliviruses share considerable structural and functional similarities. Even though disease severity varies among the respective host species, the underlying pathogenesis and the clinical signs are comparable. Thus, insights gained with one morbillivirus often apply to the other members of the genus. Since theCanine distemper virus(CDV) causes severe and often lethal disease in dogs and ferrets, it is an attractive model to characterize morbillivirus pathogenesis mechanisms and to evaluate the efficacy of new prophylactic and therapeutic approaches. This review compares the cellular tropism, pathogenesis, mechanisms of persistence and immunosuppression of theMeasles virus(MeV) and CDV. It then summarizes the contributions made by studies on the CDV in dogs and ferrets to our understanding of MeV pathogenesis and to vaccine and drugs development.
authors.affiliation: Laboratório de Virologia, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul, Porto Alegre 91540-000, Brazil. renata.fontoura@ufrgs.br.|Veterinary Medicine Division, Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Langen 63225, Germany. renata.fontoura@ufrgs.br.
authors.forename: Renata
authors.initials: R
authors.lastname: da Fontoura Budaszewski
authors.affiliation: Veterinary Medicine Division, Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Langen 63225, Germany. veronika.vonmessling@pei.de.
authors.forename: Veronika
authors.initials: V
authors.lastname: von Messling
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004217:Distemper Virus, Canine / Q000472:pathogenicity* / Q000502:physiology; D004285:Dogs; D005289:Ferrets; D006801:Humans; D057131:Immune Evasion; D007108:Immune Tolerance; D008459:Measles virus / Q000472:pathogenicity* / Q000502:physiology; D056189:Viral Tropism
keywords: animal models; canine distemper virus; morbillivirus genus; pathogenesis