title: T1Shortening in the Cerebral Cortex after Multiple Administrations of Gadolinium-based Contrast Agents.
abstract: We report a 34-year-old male who manifested T1shortening of the cerebral cortices after more than 86 contrast-enhanced MRI studies. We observed high-signal intensity (SI) on T1-weighted images (T1WIs) not only in the globus pallidus, dentate nucleus, and pulvinar of thalamus, but also in the cortices of the pre- and post-central gyri and around the calcarine sulcus. High SI in the cerebral cortices was not clearly demonstrated on T1WI scans performed 11 years earlier. The high SI we observed in these areas of the brain corresponded to areas with a normal iron-deposition predilection. Gadolinium deposition in the brain may be associated with the iron metabolism.
authors.affiliation: Department of Radiology, Faculty of Medicine, University of Miyazaki.
authors.forename: Zaw Aung
authors.initials: ZA
authors.lastname: Khant
authors.forename: Toshinori
authors.initials: T
authors.lastname: Hirai
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Kadota
authors.forename: Rie
authors.initials: R
authors.lastname: Masuda
authors.forename: Takanori
authors.initials: T
authors.lastname: Yano
authors.forename: Minako
authors.initials: M
authors.lastname: Azuma
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Kuniyuki
authors.initials: K
authors.lastname: Tashiro
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000187:drug effects* / Q000473:pathology*; D003287:Contrast Media / Q000009:adverse effects*; D005682:Gadolinium; D019786:Gadolinium DTPA / Q000009:adverse effects*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media; D005682:Gadolinium; D019786:Gadolinium DTPA