title: Hybrid molecularly imprinted polymers modified by deep eutectic solvents and ionic liquids with three templates for the rapid simultaneous purification of rutin, scoparone, and quercetin from Herba Artemisiae Scopariae.
abstract: Different kinds of deep eutectic solvents based on choline chloride and ionic liquids based on 1-methylimidazole were used to modify hybrid molecularly imprinted polymers with the monomer γ-aminopropyltriethoxysilane-methacrylic and three templates (rutin, scoparone, and quercetin). The materials were adopted as solid-phase extraction packing agents, and were characterized by FTIR spectroscopy and field emission scanning electron microscopy. The hybrid molecularly imprinted polymers modified by deep eutectic solvents had high recoveries and a strong recognition of rutin, scoparone, and quercetin in Herba Artemisiae Scopariae than those modified by ionic liquids. In the procedure of solid-phase extraction, deep eutectic solvents-2-hybrid molecularly imprinted polymers were obtained with the best recoveries with rutin (92.27%), scoparone (87.51%), and quercetin (80.02%), and the actual extraction yields of rutin (5.6 mg/g), scoparone (2.3 mg/g), and quercetin (3.4 mg/g). Overall, the proposed approach with the high affinity of hybrid molecularly imprinted polymers might offer a novel method for the purification of complex samples.
authors.affiliation: Department of Chemistry and Chemical Engineering, Inha University, Incheon, Korea.
authors.forename: Guizhen
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Chemistry and Chemical Engineering, Inha University, Incheon, Korea.
authors.forename: Wha Seung
authors.initials: WS
authors.lastname: Ahn
authors.affiliation: Department of Chemistry and Chemical Engineering, Inha University, Incheon, Korea.
authors.forename: Kyung Ho
authors.initials: KH
authors.lastname: Row
mesh_terms: D019306:Artemisia / Q000737:chemistry*; D003374:Coumarins / Q000302:isolation & purification*; D052578:Ionic Liquids; D054802:Molecular Imprinting; D011108:Polymers; D011794:Quercetin / Q000302:isolation & purification*; D012431:Rutin / Q000302:isolation & purification*; D052616:Solid Phase Extraction; D012997:Solvents
chemical_list: D003374:Coumarins; D052578:Ionic Liquids; D011108:Polymers; D012997:Solvents; D012431:Rutin; D011794:Quercetin; C018145:scoparone
keywords: Deep eutectic solvents; Ionic liquids; Molecularly imprinted polymers; Solid-phase extraction; Templates