title: Influence of random urine albumin-creatinine ratio of pregnant women with hypertension during the gestation period on perinatal outcome.
abstract: The aim of the present study was to investigate the influence of the random urine albumin-creatinine ratio (ACR) of pregnant women with hypertension during the gestation period on perinatal outcome. A total of 6,758 pregnant women with pregnancy-induced hypertension and proteinuria were randomly selected between September, 2009 and June, 2015 for the study. Kidney function, blood pressure, history of gravidity and parity, embryo number and the birth weight of the participants was determined. Logistic regression and paired data correlation analyses were carried out with kidney function, blood pressure, history of gravidity and parity, embryo number, birth weight, maternal age, labor presentation and other risk factors as the independent variables and the newborn APGAR score as the dependent variable. The results showed that random urine ACR was increased and negatively correlated with the APGAR score (OR=-0.095, P=0.017). In conclusion, the increased random urine ACR can influence the postpartum outcome. Early intervention of women of childbearing age in early pregnancy or before pregnancy can minimize the adverse complications of infants and mothers such as pregnancy hypertension syndrome, and improve the outcome of the pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology, Yantaishan Hospital, Yantai, Shandong 264001, P.R. China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Yan
authors.affiliation: Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Jinan, Shandong 250021, P.R. China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology, Yantaishan Hospital, Yantai, Shandong 264001, P.R. China.
authors.forename: Ronghui
authors.initials: R
authors.lastname: Liu
authors.affiliation: Department of Obstetrics and Gynecology, Yantaishan Hospital, Yantai, Shandong 264001, P.R. China.
authors.forename: Ling
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Department of Obstetrics and Gynecology, Yantaishan Hospital, Yantai, Shandong 264001, P.R. China.
authors.forename: Jingying
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Obstetrics and Gynecology, Zhaoyuan People's Hospital, Zhaoyuan, Shandong 265400, P.R. China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Wang
authors.affiliation: School of Public Health, Jilin University, Changchun, Jilin 130021, P.R. China.
authors.forename: Yuanying
authors.initials: Y
authors.lastname: Guo
keywords: hypertension; logistic regression analysis; pregnancy; urinary albumin-creatinine ratio