title: An in-tether sulfilimine chiral center induces β-turn conformation in short peptides.
abstract: A sulfilimine chiral center in the tether at i, i + 3 positions of short peptides was systematically studied to elucidate the chirality-driven conformational changes. A rare and unexpected type III β-turn structure was induced in short peptides by an in-tether chiral center, supported by circular dichroism spectroscopy, NMR and X-ray crystallography.
authors.affiliation: School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China. lizg@pkusz.edu.cn.
authors.forename: Huacan
authors.initials: H
authors.lastname: Lin
authors.affiliation: School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China. lizg@pkusz.edu.cn.
authors.forename: Yixiang
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China. lizg@pkusz.edu.cn.
authors.forename: Kuan
authors.initials: K
authors.lastname: Hu
authors.affiliation: School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China. lizg@pkusz.edu.cn.
authors.forename: Qingzhou
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong 518060, China. hecx@szu.edu.cn.
authors.forename: Chuanxin
authors.initials: C
authors.lastname: He
authors.affiliation: Department of Biology, South University of Science and Technology, Shenzhen, 518055, China. wangtao@sustc.edu.cn.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China. lizg@pkusz.edu.cn.
authors.forename: Zigang
authors.initials: Z
authors.lastname: Li
mesh_terms: D007097:Imines / Q000737:chemistry*; D008958:Models, Molecular; D009842:Oligopeptides / Q000737:chemistry*; D000072757:Protein Conformation, beta-Strand; D013237:Stereoisomerism
chemical_list: D007097:Imines; D009842:Oligopeptides; C586946:sulfilimine