title: The underappreciated in vitro activity of tedizolid against Bacteroides fragilis species, including strains resistant to metronidazole and carbapenems.
abstract: Because Bacteroides fragilis has the ability to develop mechanisms of resistance to almost all antibiotics, we studied the comparative in vitro activity of tedizolid against 124 Bacteroides group species clinical isolates, including carbapenem, metronidazole and piperacillin-tazobactam resistant strains. Tedizolid had an MIC90of 2 μg/ml (range, 0.5-4 μg/ml) and was 1-4 times more active than linezolid that had an MIC90of 8 μg/ml (range, 2-16 μg/ml). It was also active (MICs 0.5-2 μg/ml) against the 27 ertapenem, 2 metronidazole and 12 piperacillin-tazobactam resistant strains tested. This suggests that tedizolid may be useful treating infections, including bacteremias, due to resistant B. fragilis group species, as well as, mixed skin and soft tissue infections such as diabetic foot infections caused by Gram-positive aerobes and B. fragilis group species.
authors.affiliation: R. M. Alden Research Laboratory, Culver City, CA 90230, USA; The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address: ejcgmd@aol.com.
authors.forename: Ellie J C
authors.initials: EJ
authors.lastname: Goldstein
authors.affiliation: R. M. Alden Research Laboratory, Culver City, CA 90230, USA.
authors.forename: Diane M
authors.initials: DM
authors.lastname: Citron
authors.affiliation: R. M. Alden Research Laboratory, Culver City, CA 90230, USA.
authors.forename: Kerin L
authors.initials: KL
authors.lastname: Tyrrell
authors.affiliation: R. M. Alden Research Laboratory, Culver City, CA 90230, USA.
authors.forename: Elisa S
authors.initials: ES
authors.lastname: Leoncio
authors.affiliation: R. M. Alden Research Laboratory, Culver City, CA 90230, USA.
authors.forename: C Vreni
authors.initials: CV
authors.lastname: Merriam
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001442:Bacteroides Infections / Q000188:drug therapy* / Q000382:microbiology*; D001441:Bacteroides fragilis / Q000187:drug effects* / Q000302:isolation & purification; D015780:Carbapenems / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D008795:Metronidazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000494:pharmacology*; D010397:Penicillanic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D010878:Piperacillin / Q000494:pharmacology; D000077725:Piperacillin, Tazobactam Drug Combination; D013777:Tetrazoles / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D023303:Oxazolidinones; D013777:Tetrazoles; D008795:Metronidazole; D000077725:Piperacillin, Tazobactam Drug Combination; D010397:Penicillanic Acid; C546016:tedizolid; D010878:Piperacillin
keywords: B. fragilis; Susceptibility; Tedizolid