title: An Ni-PyBisulidine complex for the asymmetric hydrophosphonylation of aldehydes.
abstract: A novel Ni-PyBisulidine complex has been developed for the asymmetric hydrophosphonylation of aldehydes. A variety of aromatic, heteroaromatic, condensed-ring, α,β-unsaturated, and aliphatic aldehydes are found to be suitable substrates for the reaction, and the desired α-hydroxy phosphonates are obtained in up to 99% yield and 97% ee.
authors.affiliation: School of Pharmaceutical Science, Chongqing Research Center for Pharmaceutical Engineering, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing 400016, P. R. China. hzhou@cqmu.edu.cn.
authors.forename: Youmao
authors.initials: Y
authors.lastname: Zeng
authors.affiliation: School of Pharmaceutical Science, Chongqing Research Center for Pharmaceutical Engineering, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing 400016, P. R. China. hzhou@cqmu.edu.cn.
authors.forename: Ping
authors.initials: P
authors.lastname: Deng
authors.affiliation: School of Pharmaceutical Science, Chongqing Research Center for Pharmaceutical Engineering, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing 400016, P. R. China. hzhou@cqmu.edu.cn.
authors.forename: Shixiong
authors.initials: S
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Science, Chongqing Research Center for Pharmaceutical Engineering, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing 400016, P. R. China. hzhou@cqmu.edu.cn.
authors.forename: Hong
authors.initials: H
authors.lastname: Yan
authors.affiliation: School of Pharmaceutical Science, Chongqing Research Center for Pharmaceutical Engineering, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing 400016, P. R. China. hzhou@cqmu.edu.cn.
authors.forename: Guojuan
authors.initials: G
authors.lastname: Liang
authors.affiliation: School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400030, P. R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xiong
authors.affiliation: School of Pharmaceutical Science, Chongqing Research Center for Pharmaceutical Engineering, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing 400016, P. R. China. hzhou@cqmu.edu.cn.
authors.forename: Hui
authors.identifier: http://orcid.org/0000-0001-7018-3277
authors.initials: H
authors.lastname: Zhou