title: Identifying the Ion Channels Responsible for Signaling Gastro-Intestinal Based Pain.
abstract: We are normally unaware of the complex signalling events which continuously occur within our internal organs. Most of us only become cognisant when sensations of hunger, fullness, urgency or gas arise. However, for patients with organic and functional bowel disorders pain is an unpleasant and often debilitating reminder. Furthermore, chronic pain still represents a large unmet need for clinical treatment. Consequently, chronic pain has a considerable economic impact on health care systems and the afflicted individuals. In order to address this need we must understand how symptoms are generated within the gut, the molecular pathways responsible for generating these signals and how this process changes in disease states.
authors.affiliation: Nerve-Gut Research Laboratory, Department of Gastroenterology & Hepatology, Hanson Institute, Royal Adelaide Hospital, Adelaide, South Australia, 5000, Australia. stuart.brierley@adelaide.edu.au.|Disciplines of Medicine, The University of Adelaide, Adelaide, South Australia, 5000, Australia. stuart.brierley@adelaide.edu.au.|Disciplines of Physiology, The University of Adelaide, Adelaide, South Australia, 5000, Australia. stuart.brierley@adelaide.edu.au.
authors.forename: Stuart M
authors.initials: SM
authors.lastname: Brierley
authors.affiliation: Nerve-Gut Research Laboratory, Department of Gastroenterology & Hepatology, Hanson Institute, Royal Adelaide Hospital, Adelaide, South Australia, 5000, Australia. patrick.hughes@adelaide.edu.au.|Disciplines of Medicine, The University of Adelaide, Adelaide, South Australia, 5000, Australia. patrick.hughes@adelaide.edu.au.
authors.forename: Patrick A
authors.initials: PA
authors.lastname: Hughes
authors.affiliation: Nerve-Gut Research Laboratory, Department of Gastroenterology & Hepatology, Hanson Institute, Royal Adelaide Hospital, Adelaide, South Australia, 5000, Australia. andrea.harrington@adelaide.edu.au.|Disciplines of Medicine, The University of Adelaide, Adelaide, South Australia, 5000, Australia. andrea.harrington@adelaide.edu.au.
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Harrington
authors.affiliation: Disciplines of Physiology, The University of Adelaide, Adelaide, South Australia, 5000, Australia. grigori.rychkov@adelaide.edu.au.
authors.forename: Grigori Y
authors.initials: GY
authors.lastname: Rychkov
authors.affiliation: Nerve-Gut Research Laboratory, Department of Gastroenterology & Hepatology, Hanson Institute, Royal Adelaide Hospital, Adelaide, South Australia, 5000, Australia. ashley.blackshaw@adelaide.edu.au.|Disciplines of Medicine, The University of Adelaide, Adelaide, South Australia, 5000, Australia. ashley.blackshaw@adelaide.edu.au.|Disciplines of Physiology, The University of Adelaide, Adelaide, South Australia, 5000, Australia. ashley.blackshaw@adelaide.edu.au.
authors.forename: L Ashley
authors.initials: LA
authors.lastname: Blackshaw
keywords: ASICs; NaV and KV channels; TRPA1; TRPV1; TRPV4; visceral pain