title: Depressive Symptoms Contribute to Executive Deficits in Temporal Lobe Epilepsy.
abstract: This study examined the contribution of depression to reduced executive functioning in temporal lobe epilepsy (TLE) using three groups: TLE only (TLE; N=29), TLE+depression (TLE+DEP) (N=22), and nonneurologic participants with depression (DEP; N=31). Participants completed the Delis-Kaplan Executive Function System. Individuals with TLE performed worse than the DEP group on many tests of executive functions. Among the TLE participants, those with depression demonstrated poorer executive functioning. These findings support the notion that depression may further contribute to executive difficulties in individuals with TLE. Depression treatment in this population could lead to improvements in cognition.
authors.affiliation: From the Warren Alpert Medical School of Brown University, Providence, R.I. (RG, GT, JD); and Rhode Island Hospital, Providence, R.I. (RG, GT, ASB, WCL, JD).
authors.forename: Rachel
authors.initials: R
authors.lastname: Galioto
authors.affiliation: From the Warren Alpert Medical School of Brown University, Providence, R.I. (RG, GT, JD); and Rhode Island Hospital, Providence, R.I. (RG, GT, ASB, WCL, JD).
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Tremont
authors.affiliation: From the Warren Alpert Medical School of Brown University, Providence, R.I. (RG, GT, JD); and Rhode Island Hospital, Providence, R.I. (RG, GT, ASB, WCL, JD).
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Blum
authors.affiliation: From the Warren Alpert Medical School of Brown University, Providence, R.I. (RG, GT, JD); and Rhode Island Hospital, Providence, R.I. (RG, GT, ASB, WCL, JD).
authors.forename: W Curt
authors.initials: WC
authors.lastname: LaFrance
authors.affiliation: From the Warren Alpert Medical School of Brown University, Providence, R.I. (RG, GT, JD); and Rhode Island Hospital, Providence, R.I. (RG, GT, ASB, WCL, JD).
authors.forename: Cara L
authors.initials: CL
authors.lastname: Crook
authors.affiliation: From the Warren Alpert Medical School of Brown University, Providence, R.I. (RG, GT, JD); and Rhode Island Hospital, Providence, R.I. (RG, GT, ASB, WCL, JD).
authors.forename: Jennifer D
authors.initials: JD
authors.lastname: Davis
mesh_terms: D000328:Adult; D060825:Cognitive Dysfunction / Q000175:diagnosis / Q000209:etiology*; D003863:Depression / Q000150:complications* / Q000209:etiology*; D004833:Epilepsy, Temporal Lobe / Q000150:complications*; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis; D014705:Verbal Behavior; D055815:Young Adult
keywords: Depression; Neuropsychology; Seizures