title: Extracranial oral cavity metastasis from glioblastoma multiforme: A case report.
abstract: Glioblastoma multiforme is the most common primary malignant brain tumor. The clinical outcome following diagnosis remains extremely poor. The treatment of choice is wide surgical resection of the visible tumor, frequently followed by adjuvant combined radiochemotherapy (RCTx) with temozolomide as the chemotherapeutic agent. Extracranial metastases are extremely rare, with <200 cases of extracranial metastases from glioblastoma multiforme reported in the literature to date. We herein present a case of a patient suffering from a fast-growing metastasis to the oral cavity, completely filling the buccal cavity within 2 weeks, as the only manifestation of recurrent glioblastoma multiforme following initial surgical resection and adjuvant RCTx.
authors.affiliation: Department of Radiation Oncology, Marien Hospital Herne, Ruhr University Bochum, D-44625 Herne, Germany; Department of Radiation Oncology, St. Josef Hospital Bochum, Ruhr University Bochum, D-44791 Bochum, Germany.
authors.forename: Philipp Günther
authors.initials: PG
authors.lastname: Kup
authors.affiliation: Department of Oncology and Palliative Medicine, Nordland Hospital, 8005 Bodø, Norway.
authors.forename: Carsten
authors.initials: C
authors.lastname: Nieder
authors.affiliation: Department of Radiology, Marien Hospital Herne, Ruhr University Bochum, D-44625 Herne, Germany.
authors.forename: Guido
authors.initials: G
authors.lastname: Winnekendonk
authors.affiliation: Department of Radiation Oncology, Marien Hospital Herne, Ruhr University Bochum, D-44625 Herne, Germany; Department of Radiation Oncology, St. Josef Hospital Bochum, Ruhr University Bochum, D-44791 Bochum, Germany.
authors.forename: Irenäus Anton
authors.initials: IA
authors.lastname: Adamietz
authors.affiliation: Department of Radiation Oncology, Marien Hospital Herne, Ruhr University Bochum, D-44625 Herne, Germany; Department of Radiation Oncology, St. Josef Hospital Bochum, Ruhr University Bochum, D-44791 Bochum, Germany.
authors.forename: Khashayar
authors.initials: K
authors.lastname: Fakhrian
keywords: extracranial metastases; glioblastoma multiforme; oral cavity metastasis