title: Outstanding Symptoms of Poststroke Depression during the Acute Phase of Stroke.
abstract: Poststroke depression (PSD) is a critical complication which might lead to unfavorable outcomes. However, most cases of PSD in the acute phase, during the 2 or 3 weeks following a stroke, are neglected because of the variable comorbid conditions. In this study, aimed at revealing the outstanding symptoms of PSD during the acute phase, consecutive patients with intracranial hemorrhage (ICH) or brain infarction (BI) were asked to fill out a depression questionnaire (Quick Inventory of Depressive Symptomatology Self-Report: QIDS-SR) at 1 week and 1 month following stroke onset. Patients with disturbed consciousness or aphasia were excluded from this study. Forty-nine ICH patients and 222 BI patients completed the QIDS-SR at 1 week and 27 of ICH and 62 of BI at 1 month. The PSD rate was 67% and 46% at 1 week in ICH and BI, respectively. Although sleep disturbance was the most frequent symptom of PSD, psychomotor agitation and appetite disturbance were the most distinguishing symptoms in ICH at 1 week and fatigue at 1 month. On the other hand, most of the depressive symptoms addressed in QIDS-SR were observed in PSD of BI patients both at 1 week and 1 month. In conclusion, while sleep disturbance was a frequent but non-specific symptom, appetite disturbance and fatigue might be critical symptoms to suggest PSD during the acute phase of stroke.
authors.affiliation: Department of Stroke Science, Research Institute for Brain and Blood Vessels-Akita, Akita, Japan.
authors.forename: Taizen
authors.initials: T
authors.lastname: Nakase
authors.affiliation: Department of Stroke Science, Research Institute for Brain and Blood Vessels-Akita, Akita, Japan.
authors.forename: Maiko
authors.initials: M
authors.lastname: Tobisawa
authors.affiliation: Department of Stroke Science, Research Institute for Brain and Blood Vessels-Akita, Akita, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sasaki
authors.affiliation: Department of Stroke Science, Research Institute for Brain and Blood Vessels-Akita, Akita, Japan.
authors.forename: Akifumi
authors.initials: A
authors.lastname: Suzuki
mesh_terms: D000208:Acute Disease; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging; D020520:Brain Infarction / Q000150:complications / Q000175:diagnosis; D003866:Depressive Disorder / Q000175:diagnosis / Q000209:etiology*; D005221:Fatigue / Q000209:etiology; D005260:Female; D006801:Humans; D020300:Intracranial Hemorrhages / Q000150:complications / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011595:Psychomotor Agitation / Q000209:etiology; D012720:Severity of Illness Index; D012893:Sleep Wake Disorders / Q000209:etiology; D020521:Stroke / Q000150:complications* / Q000175:diagnosis; D011795:Surveys and Questionnaires; D013997:Time Factors; D014057:Tomography, X-Ray Computed