title: Alcohol-associated cancer and deregulation of Pol III genes.
abstract: Emerging evidence indicates that alcohol intake is associated with human cancers in different organs. However, the molecular mechanism of alcohol-associated human cancers remains to be elucidated. Here, this paper aimed to clarify a novel mechanism of alcohol-promoted cell transformation and tumor development. Alcohol induces JNK1 activation and increases cellular levels of c-Jun to upregulate Brf1 expression and Pol III gene transcription, leading to an enhancement of rates of cell transformation and tumor formation.
authors.affiliation: Shantou University Medical College, Shantou, Guangdong Province, China.
authors.forename: Ganggang
authors.initials: G
authors.lastname: Shi
authors.affiliation: Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: szhong@usc.edu.
authors.forename: Shuping
authors.initials: S
authors.lastname: Zhong
mesh_terms: D000431:Ethanol / Q000009:adverse effects*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D006801:Humans; D009369:Neoplasms / Q000139:chemically induced* / Q000235:genetics; D012320:RNA Polymerase III / Q000235:genetics*
chemical_list: D000431:Ethanol; D012320:RNA Polymerase III
keywords: Alcohol; Breast cancer; Brf1; HCC; Pol III genes