title: Responsiveness of 8 Patient-Reported Outcomes Measurement Information System (PROMIS) measures in a large, community-based cancer study cohort.
abstract: The Patient-Reported Outcomes Measurement Information System (PROMIS) was a National Institutes of Health-funded initiative to develop measures of symptoms and function. Responsiveness is the degree to which a measure can detect underlying changes over time. The objective of the current study was to document the responsiveness of 8 PROMIS measures in a large, population-based cancer cohort.
  
  
  
  The Measuring Your Health study recruited 2968 patients who were diagnosed with 1 of 7 cancers between 2010 and 2012 through 4 Surveillance, Epidemiology, and End Results registries. Participants completed a baseline survey (6-13 months after diagnosis) and a 6-month follow-up survey. Changes in 8 PROMIS scores were compared with global ratings of transition, changes in performance status, and clinical events.
  
  
  
  Measures were responsive to 6-month declines and improvements in performance status with small to large effect sizes (ES) (Cohen d = 0.34-0.71; P < .01). Mean changes and effect sizes were larger for participants who reported declines compared with those who reported improvements. Small-to-medium ES were observed in patients who reported being "a little" worse (d = 0.31-0.56), and medium-to-large ES were observed in those who reported being "a lot" worse (d = 0.53-0.72). Hospitalized participants reported significant score increases, resulting in worsening of pain (d = 0.51), fatigue (d = 0.35), and depression (d = 0.57; all P < .01). Cancer recurrence and progression were associated with smaller increases in pain, fatigue, and sleep disturbance (d = 0.22-0.27).
  
  
  
  The current results indicated that all 8 PROMIS measures were sensitive to patient-perceived worsening and improvement and to major clinical events. These findings will be able to inform the design and interpretation of future research studies and clinical initiatives administering PROMIS measures. Cancer 2017;123:327-335. © 2016 American Cancer Society.
authors.affiliation: Department of Oncology, Georgetown University, Washington, DC.|Cancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Washington, District of Columbia.
authors.forename: Roxanne E
authors.initials: RE
authors.lastname: Jensen
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, Washington.
authors.forename: Carol M
authors.initials: CM
authors.lastname: Moinpour
authors.affiliation: Department of Oncology, Georgetown University, Washington, DC.|Cancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Washington, District of Columbia.
authors.forename: Arnold L
authors.initials: AL
authors.lastname: Potosky
authors.affiliation: Cancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Washington, District of Columbia.
authors.forename: Tania
authors.initials: T
authors.lastname: Lobo
authors.affiliation: Northwestern University Feinberg School of Medicine, Chicago, Illinois.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Hahn
authors.affiliation: University of California-Los Angeles Department of Medicine, Los Angeles, California.
authors.forename: Ron D
authors.initials: RD
authors.lastname: Hays
authors.affiliation: Northwestern University Feinberg School of Medicine, Chicago, Illinois.
authors.forename: David
authors.initials: D
authors.lastname: Cella
authors.affiliation: Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland.
authors.forename: Ashley Wilder
authors.initials: AW
authors.lastname: Smith
authors.affiliation: Lousiana State University Health Sciences Center School of Public Health, Louisiana Tumor Registry, New Orleans, Louisiana.
authors.forename: Xiao-Cheng
authors.initials: XC
authors.lastname: Wu
authors.affiliation: Department of Internal Medicine, Division of Hematology and Oncology, University of California-Davis School of Medicine, Sacramento, California.
authors.forename: Theresa H M
authors.initials: TH
authors.lastname: Keegan
authors.affiliation: Cancer Epidemiology Services, New Jersey Department of Health, Trenton, New Jersey.|Rutgers School of Public Health and Cancer Institute of New Jersey, New Brunswick, New Jersey.
authors.forename: Lisa E
authors.initials: LE
authors.lastname: Paddock
authors.affiliation: Cancer Epidemiology Services, New Jersey Department of Health, Trenton, New Jersey.
authors.forename: Antoinette M
authors.initials: AM
authors.lastname: Stroup
authors.affiliation: Division of Health Care Policy and Research, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
authors.forename: David T
authors.initials: DT
authors.lastname: Eton
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003863:Depression / Q000209:etiology / Q000503:physiopathology; D005221:Fatigue / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications* / Q000503:physiopathology*; D010146:Pain / Q000209:etiology / Q000503:physiopathology; D010147:Pain Measurement / Q000379:methods; D000071066:Patient Reported Outcome Measures; D011788:Quality of Life; D057566:Self Report; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: oncology; patient-reported outcomes; responsiveness; validation studies