title: Synthesis of HIV-1 capsid protein assembly inhibitor (CAP-1) and its analogues based on a biomass approach.
abstract: A biomass-derived platform chemical was utilized to access a demanded pharmaceutical substance with anti-HIV activity (HIV, human immunodeficiency virus) and a variety of structural analogues. Step economy in the synthesis of the drug core (single stage from cellulose) is studied including flexible variability of four structural units. The first synthesis and X-ray structure of the inhibitor of HIV-1 capsid protein assembly (CAP-1) is described.
authors.affiliation: Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prospect 47, 119991 Moscow, Russia. val@ioc.ac.ru.
authors.forename: Leonid V
authors.initials: LV
authors.lastname: Romashov
authors.forename: Valentine P
authors.initials: VP
authors.lastname: Ananikov
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D018533:Biomass; D036022:Capsid Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002482:Cellulose / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D015658:HIV Infections / Q000188:drug therapy; D015497:HIV-1 / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular
chemical_list: D019380:Anti-HIV Agents; D036022:Capsid Proteins; D002482:Cellulose