title: 1H-1,2,3-Triazolyl-substituted 1,3,4-oxadiazole derivatives containing structural features of ibuprofen/naproxen: Their synthesis and antibacterial evaluation.
abstract: 1H-1,2,3-Triazolyl-substituted 1,3,4-oxadiazole derivatives containing structural features of ibuprofen/naproxen were synthesized for the first time using a Cu catalyzed azide-alkyne cycloaddition (CuAAC) strategy. An optimized reaction condition was established for this purpose and twenty new compounds were synthesized using this methodology. Several of these compounds showed good to reasonable antibacterial activities when tested against three gram-positive and three gram-negative species. The compound 4m i.e. N-(2-chlorophenyl)-2-(4-((5-(1-(6-methoxynaphthalen-2-yl)ethyl)-1,3,4-oxadiazol-2-ylthio)methyl)-1H-1,2,3-triazol-1-yl)acetamide showed promising activities across both the species.
authors.affiliation: Department of Chemistry, DVR College of Engineering & Technology, Kashipur Village, Medak District, Telangana 502285, India.
authors.forename: Papigani
authors.initials: P
authors.lastname: Neeraja
authors.affiliation: BIOCON LTD, Plot No 213, 214 & 215, IDA Phase-2, Pashamylaram, Medak (dist), Telangana 502307, India.
authors.forename: Suryapeta
authors.initials: S
authors.lastname: Srinivas
authors.affiliation: Centre for Chemical Sciences and Technology, Institute of Science and Technology, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad 500085, India.
authors.forename: Khagga
authors.initials: K
authors.lastname: Mukkanti
authors.affiliation: Department of Medicinal Chemistry, NIPER, Hyderabad 500037, India.
authors.forename: Pramod Kumar
authors.initials: PK
authors.lastname: Dubey
authors.affiliation: Department of Chemistry, MNR Degree & PG College, Kukatpally, Hyderabad 500085, India. Electronic address: sarbani277@yahoo.com.
authors.forename: Sarbani
authors.initials: S
authors.lastname: Pal
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D014230:Triazoles
keywords: 1,2,3-Triazole; Alkyne; Antibacterial activity; Azide; Ibuprofen; Naproxen