title: Supramolecular Virus-Like Nanorods by Coassembly of a Triblock Polypeptide and Reversible Coordination Polymers.
abstract: We investigate a new case of a self-assembly-stimulated self-assembly in which a triblock polypeptide is combined with a anionic coordination polymer of a dipicolinic acid bis-ligand, and d- or f- block metal ions like ZnIIor EuIII. The polypeptide not only has a silk-like domain that can fold and stack, but also a C-terminal cationic sequence by which it can interact with the supramolecular (coordination) polyanion. In the presence of all three ingredients (polypeptide, bis-ligand, and metal ions), we observe the initiation and slow growth of well-defined metal-containing nanorods of up to 150 nm in length, proving that self-assembly of the polypeptide is triggered by the self-assembly of the coordination polyelectrolyte and vice versa. The particles, which have a striking resemblance to rod-like viruses, are stable up to 1.2 m NaCl, and can be made fluorescent when lanthanides like EuIIIare used, showing the potential to exploit functional properties and applications of virus-like supramolecular structures.
authors.affiliation: Laboratory of Physical Chemistry and Soft Matter, Wageningen University and Research Centre, Wageningen, 6703HB, The Netherlands.|Simpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, Illinois, 60611-2875, USA.
authors.forename: Armando
authors.initials: A
authors.lastname: Hernandez-Garcia
authors.affiliation: Laboratory of Bionanotechnology, Wageningen University and Research Centre, Wageningen, 6703HB, The Netherlands.
authors.forename: Aldrik H
authors.initials: AH
authors.lastname: Velders
authors.affiliation: Laboratory of Physical Chemistry and Soft Matter, Wageningen University and Research Centre, Wageningen, 6703HB, The Netherlands.
authors.forename: Martien A Cohen
authors.initials: MA
authors.lastname: Stuart
authors.affiliation: Laboratory of Physical Chemistry and Soft Matter, Wageningen University and Research Centre, Wageningen, 6703HB, The Netherlands.
authors.forename: Renko
authors.initials: R
authors.lastname: de Vries
authors.affiliation: Wageningen Electron Microscopy Centre, Wageningen University and Research Centre, Droevendaalsesteeg 1, 6708 PB, Wageningen, The Netherlands.
authors.forename: Jan W M
authors.initials: JW
authors.lastname: van Lent
authors.affiliation: Laboratory of Bionanotechnology, Wageningen University and Research Centre, Wageningen, 6703HB, The Netherlands.
authors.forename: Junyou
authors.initials: J
authors.lastname: Wang
mesh_terms: D056831:Coordination Complexes / Q000737:chemistry*; D005063:Europium / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D010455:Peptides / Q000737:chemistry*; D000071228:Polyelectrolytes; D011108:Polymers / Q000737:chemistry*; D014780:Viruses / Q000737:chemistry; D015032:Zinc / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D005063:Europium; D005456:Fluorescent Dyes; D010455:Peptides; D000071228:Polyelectrolytes; D011108:Polymers; D015032:Zinc
keywords: coordination polymers; hybrid nanomaterials; polypeptides; protein engineering; self-assembly