title: Serum concentration of CD40L is elevated in inflammatory demyelinating diseases.
abstract: It is believed that auto-inflammatory activity, including cellular and humoral immunity responses, especially T cell-B cell collaboration, is one of the most important components of the pathogenesis of inflammatory demyelinating disease. CD40L is critical for T cell-B cell collaboration. Actually, serum CD40L levels have been shown to increase in MS. In the present study, serum CD40L levels were measured by an enzyme-linked immunosorbent assay (ELISA) in NMO (n=27) and MS (n=19) patients and controls (n=14). We revealed elevation of CD40L in NMO patients, and discovered a correlation between CD40L and humoral immunity in inflammatory demyelinating disease.
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
authors.forename: Xiaonan
authors.initials: X
authors.lastname: Zhong
authors.affiliation: Department of Neurology, Nangfang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China.
authors.forename: Honghao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Emergency, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Ye
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Qiu
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
authors.forename: Zhengqi
authors.initials: Z
authors.lastname: Lu
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Li
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
authors.forename: Yaqing
authors.initials: Y
authors.lastname: Shu
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
authors.forename: Yanyu
authors.initials: Y
authors.lastname: Chang
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China. Electronic address: huxueqiangzssy@qq.com.
authors.forename: Xueqiang
authors.initials: X
authors.lastname: Hu
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D023201:CD40 Ligand / Q000097:blood* / Q000276:immunology; D002648:Child; D003711:Demyelinating Diseases / Q000097:blood / Q000175:diagnosis / Q000276:immunology; D005260:Female; D006801:Humans; D056724:Immunity, Humoral / Q000276:immunology; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood* / Q000175:diagnosis* / Q000276:immunology; D009471:Neuromyelitis Optica / Q000097:blood* / Q000175:diagnosis* / Q000276:immunology; D055815:Young Adult
chemical_list: D015415:Biomarkers; D023201:CD40 Ligand
keywords: CD40L; Multiple sclerosis; Neuromyelitis optica; Serum