title: miR-296 inhibits proliferation and induces apoptosis by targeting FGFR1 in human hepatocellular carcinoma.
abstract: MiR-296 was previously reported to be underexpressed in hepatocellular carcinoma (HCC). However, the clinical value of miR-296 and its function in HCC remain poorly understood. In this study, we found that miR-296 levels are decreased in HCC specimens and cells, and that the underexpression of miR-296 is associated with adverse clinical parameters and poor overall survival rate. In vitro experiments indicate that miR-296 inhibits proliferation, colony formation, and cell cycle progression, and enhances apoptosis in HCC cells. Notably, we found that the fibroblast growth factor receptor 1 (FGFR1) is a downstream target that mediates the functions of miR-296 in HCC. Thus, our findings indicate that miR-296 exerts a tumor suppressive role in HCC and is a potential biomarker and drug-target.
authors.affiliation: Department of Gastroenterology, Affiliated Hospital of Guilin Medical University, China.
authors.forename: Liyan
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology, Affiliated Hospital of Guilin Medical University, China.
authors.forename: Xiaotong
authors.initials: X
authors.lastname: Bo
authors.affiliation: Department of Gastroenterology, Affiliated Hospital of Guilin Medical University, China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Zheng
authors.affiliation: Department of Gastroenterology, Affiliated Hospital of Guilin Medical University, China.
authors.forename: Xuhua
authors.initials: X
authors.lastname: Xiao
authors.affiliation: Department of Gastroenterology, Affiliated Hospital of Guilin Medical University, China.
authors.forename: Linling
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Gastroenterology, Affiliated Hospital of Guilin Medical University, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
mesh_terms: D017209:Apoptosis / Q000235:genetics*; D001483:Base Sequence; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology*; D002453:Cell Cycle / Q000235:genetics; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000235:genetics; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology*; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D011379:Prognosis; D051496:Receptor, Fibroblast Growth Factor, Type 1 / Q000235:genetics*
chemical_list: C549871:MIRN296 microRNA, human; D035683:MicroRNAs; D051496:Receptor, Fibroblast Growth Factor, Type 1
keywords: FGFR1; apoptosis; cell cycle; cell proliferation; hepatocellular carcinoma; miR-296