title: Palatal botulinum toxin as a novel therapy for objective tinnitus in forced eyelid closure syndrome.
abstract: Objective tinnitus associated with eyelid closure is a rare clinical entity with only a few reported cases. This association previously was identified as forced eyelid closure syndrome (FECS) and involves an aberrant neural reflex between cranial nerve VII (activating the orbicularis oculi muscle) and cranial nerve V (activating the tensor tympani muscle). We present a 52-year-old Caucasian female with a 2-month history of FECS who was successfully treated with intrapalatal botulinum toxin, with full resolution of her objective tinnitus symptoms. This is the first reported use of botulinum toxin in FECS. Laryngoscope, 127:1199-1201, 2017.
authors.affiliation: University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Kaffenberger
authors.affiliation: Head and Neck Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, U.S.A.
authors.forename: Rajarsi
authors.initials: R
authors.lastname: Mandal
authors.affiliation: Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, U.S.A.
authors.forename: Barry M
authors.initials: BM
authors.lastname: Schaitkin
authors.affiliation: Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, U.S.A.
authors.forename: Barry E
authors.initials: BE
authors.lastname: Hirsch
mesh_terms: D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D005143:Eyelids / Q000503:physiopathology; D005154:Facial Nerve / Q000503:physiopathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000627:therapeutic use*; D010159:Palate; D013577:Syndrome; D014012:Tinnitus / Q000188:drug therapy* / Q000503:physiopathology; D014276:Trigeminal Nerve / Q000503:physiopathology
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A
keywords: FECS; botulinum toxin; objective tinnitus; palatal tinnitus