title: A Truncated IL-17RC Peptide Ameliorates Synovitis and Bone Destruction of Arthritic Mice.
abstract: Peptide-based therapy, such as modified peptides, has attracted increased attention. IL-17 is a promising therapeutic target for autoimmune diseases, and levels of circulating bioactive IL-17 are associated with rheumatoid arthritis severity. In this study, a modified truncated IL-17RC is generated to ameliorate inflammation and bone destruction in arthritis. The truncated IL-17RC binds to both IL-17A and IL-17F with higher binding capacity compared to nonmodified IL-17RC. In addition, the truncated IL-17RC reduces the secretion of inflammatory and osteoclastogenic factors induced by IL-17A/F in vitro. Moreover, the administration of truncated IL-17RC dramatically improves symptoms of inflammation and inhibited bone destruction in collagen-induced arthritis mice. Collectively, these data demonstrate that modified truncated IL-17RC peptide may be a more effective treatment strategy in the simultaneous inhibition of both IL-17A and IL-17F signaling, whereas the existing agents neutralize IL-17A or IL-17F alone. These suggest that the truncated IL-17RC may be a potential candidate in the treatment of inflammatory associated bone diseases.
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men, Beijing, 100069, P. R. China.
authors.forename: Yuxuan
authors.initials: Y
authors.lastname: Du
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men, Beijing, 100069, P. R. China.
authors.forename: Yulong
authors.initials: Y
authors.lastname: Tong
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men, Beijing, 100069, P. R. China.
authors.forename: Wentong
authors.initials: W
authors.lastname: Mei
authors.affiliation: Department of Blood transfusion, Aerospace Center Hospital, No.15, Yuquan Road, Haidian District, Beijing, 100049, P. R. China.
authors.forename: Junhui
authors.initials: J
authors.lastname: Jia
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men, Beijing, 100069, P. R. China.
authors.forename: Menglin
authors.initials: M
authors.lastname: Niu
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men, Beijing, 100069, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Cao
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men, Beijing, 100069, P. R. China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Lou
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men, Beijing, 100069, P. R. China.
authors.forename: Shentao
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Rheumatology & Immunology, Clinical Immunology Center, Peking University People's Hospital, No. 11 Xizhimen South Street, Beijing, 100044, P. R. China.
authors.forename: Zhanguo
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, 48109, USA.
authors.forename: W Alexander
authors.initials: WA
authors.lastname: Stinson
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men, Beijing, 100069, P. R. China.
authors.forename: Huihui
authors.initials: H
authors.lastname: Yuan
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men, Beijing, 100069, P. R. China.
authors.forename: Wenming
authors.initials: W
authors.lastname: Zhao
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001169:Arthritis, Experimental / Q000188:drug therapy*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001483:Base Sequence; D001847:Bone Diseases / Q000188:drug therapy*; D001842:Bone and Bones / Q000187:drug effects; D002460:Cell Line; D007249:Inflammation / Q000188:drug therapy; D020381:Interleukin-17 / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D041681:NIH 3T3 Cells; D010455:Peptides / Q000008:administration & dosage*; D000067996:RAW 264.7 Cells; D013585:Synovitis / Q000188:drug therapy*
chemical_list: D020381:Interleukin-17; D010455:Peptides
keywords: bone destruction; collagen-induced arthritis (CIA); synovitis; truncated IL-17RC peptides