title: The Relational and Item-Specific Encoding Task in Mild Cognitive Impairment and Alzheimer Disease.
abstract: The Relational and Item-Specific Encoding task (RISE) measures episodic memory subcomponents, including item-specific and relational encoding of to-be-remembered stimuli. These memory components are neurobiologically relevant because they may engage distinct subregions of the medial temporal lobe, perirhinal and entorhinal cortices, parahippocampus, and hippocampus.
  
  
  
  A total of 125 participants, including 84 healthy controls (HC), 22 mild cognitive impairment-diagnosed and 19 Alzheimer disease (AD)-diagnosed participants, were administered the RISE and neuropsychological measures. Stepwise linear regressions assessed prediction of functional ability from RISE d' measures. ANOVAs and logistic regressions determined the ability of the RISE to discriminate between the diagnostic groups. In addition, the psychometric properties of the RISE were examined.
  
  
  
  RISE measures predicted diagnosis with pseudo R2 values in the range of 0.25-0.30. Receiver operating characteristic curves demonstrated adequate sensitivity and specificity with areas under the curve in the range of 0.78-0.98. Memory following relational encoding was a significant predictor of everyday functional competence. The RISE had acceptable psychometric properties, with the exception of floor effects in the AD group.
  
  
  
  The RISE measures significantly predicted diagnosis and predicted everyday functional competence. The RISE offers unique advantages in the assessment of HC and individuals with preclinical AD.
authors.affiliation: The Litwin-Zucker Research Center, The Feinstein Institute for Medical Research, Manhasset, N.Y., USA.
authors.forename: Amber
authors.initials: A
authors.lastname: Sousa
authors.forename: Jesus J
authors.initials: JJ
authors.lastname: Gomar
authors.forename: J Daniel
authors.initials: JD
authors.lastname: Ragland
authors.forename: Concepcion
authors.initials: C
authors.lastname: Conejero-Goldberg
authors.forename: Justin
authors.initials: J
authors.lastname: Buthorn
authors.forename: Lynda
authors.initials: L
authors.lastname: Keehlisen
authors.forename: Ted E
authors.initials: TE
authors.lastname: Huey
authors.forename: Jeremy
authors.initials: J
authors.lastname: Koppel
authors.forename: Marc L
authors.initials: ML
authors.lastname: Gordon
authors.forename: Erica
authors.initials: E
authors.lastname: Christen
authors.forename: Terry E
authors.initials: TE
authors.lastname: Goldberg
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000523:psychology*; D016022:Case-Control Studies; D060825:Cognitive Dysfunction / Q000523:psychology*; D005260:Female; D006801:Humans; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008568:Memory; D061212:Memory, Episodic; D008875:Middle Aged; D011594:Psychometrics; D012372:ROC Curve