title: Iron-catalyzed oxidative sp3carbon-hydrogen bond functionalization of 3,4-dihydro-1,4-benzoxazin-2-ones.
abstract: A novel and efficient iron-catalyzed sp3carbon-hydrogen bond functionalization of benzoxazinone derivatives has been developed. For the first time, benzoxazin-2-ones were used as substrates in an oxidative dehydrogenative coupling reaction. The experiments were performed under mild reaction conditions to construct alkyl-aryl C(sp3)-C(sp2) bonds. The application of this method to the gram-scale synthesis of natural product cephalandole A has been accomplished in a 3-step sequence. A plausible one electron oxidation involved mechanism is proposed.
authors.affiliation: Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, China. huocongde1978@hotmail.com.
authors.forename: Congde
authors.initials: C
authors.lastname: Huo
authors.affiliation: Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, China. huocongde1978@hotmail.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Dong
authors.affiliation: Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, China. huocongde1978@hotmail.com.
authors.forename: Yingpeng
authors.initials: Y
authors.lastname: Su
authors.affiliation: Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, China. huocongde1978@hotmail.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Tang
authors.affiliation: Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, China. huocongde1978@hotmail.com.
authors.forename: Fengjuan
authors.initials: F
authors.lastname: Chen