title: Hyaluronic Acid and Its Derivatives in Coating and Delivery Systems: Applications in Tissue Engineering, Regenerative Medicine and Immunomodulation.
abstract: As an Extracellular Matrix (ECM) component, Hyaluronic acid (HA) plays a multi-faceted role in cell migration, proliferation and differentiation at micro level and system level events such as tissue water homeostasis. Among its biological functions, it is known to interact with cytokines and contribute to their retention in ECM microenvironment. In addition to its biological functions, it has advantageous physical properties which result in the industrial endeavors in the synthesis and extraction of HA for variety of applications ranging from medical to cosmetic. Recently, HA and its derivatives have been the focus of active research for applications in biomedical device coatings, drug delivery systems and in the form of scaffolds or cell-laden hydrogels for tissue engineering. A specific reason for the increase in use of HA based structures is their immunomodulatory and regeneration inducing capacities. In this context, this article reviews recent literature on modulation of the implantable biomaterial microenvironment by systems based on HA and its derivatives, particularly hydrogels and microscale coatings that are able to deliver cytokines in order to reduce the adverse immune reactions and promote tissue healing.
authors.affiliation: Inserm UMR 1121, 11 rue Humann, 67085, Strasbourg, France.|Faculté de Chirurgie Dentaire, Université de Strasbourg, 3 rue Sainte Elisabeth, 67000, Strasbourg, France.
authors.forename: Helena
authors.initials: H
authors.lastname: Knopf-Marques
authors.affiliation: Contipro Biotech S. R. O, Dolni Dobrouc 401, 561 02, Dolni Dobrouc, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Pravda
authors.affiliation: Contipro Biotech S. R. O, Dolni Dobrouc 401, 561 02, Dolni Dobrouc, Czech Republic.
authors.forename: Lucie
authors.initials: L
authors.lastname: Wolfova
authors.affiliation: Contipro Biotech S. R. O, Dolni Dobrouc 401, 561 02, Dolni Dobrouc, Czech Republic.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Velebny
authors.affiliation: Inserm UMR 1121, 11 rue Humann, 67085, Strasbourg, France.|Faculté de Chirurgie Dentaire, Université de Strasbourg, 3 rue Sainte Elisabeth, 67000, Strasbourg, France.|Institut Charles Sadron, CNRS UPR 22, 23 rue du Lœss, 67034, Strasbourg, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Schaaf
authors.affiliation: Inserm UMR 1121, 11 rue Humann, 67085, Strasbourg, France.|Protip Medical, 8 Place de l'Hôpital, 67000, Strasbourg, France.
authors.forename: Nihal Engin
authors.initials: NE
authors.lastname: Vrana
authors.affiliation: Inserm UMR 1121, 11 rue Humann, 67085, Strasbourg, France.|Faculté de Chirurgie Dentaire, Université de Strasbourg, 3 rue Sainte Elisabeth, 67000, Strasbourg, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Lavalle
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D020100:Hydrogels / Q000008:administration & dosage*; D056747:Immunomodulation / Q000187:drug effects*; D044968:Regenerative Medicine / Q000379:methods; D023822:Tissue Engineering / Q000379:methods; D014945:Wound Healing / Q000187:drug effects
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels; D006820:Hyaluronic Acid
keywords: biomedical; coatings; delivery systems; hyaluronic acid; immunomodulation; tissue engineering