title: OB or Not OB: Idiosyncratic utilization of the tRNA-binding OB-fold domain in unicellular, pathogenic eukaryotes.
abstract: In this review, we examine the so-called OB-fold, a tRNA-binding domain homologous to the bacterial tRNA-binding protein Trbp111. We highlight the ability of OB-fold homologs to bind tRNA species and summarize their distribution in evolution. Nature has capitalized on the advantageous effects acquired when an OB-fold domain binds to tRNA by evolutionarily selecting this domain for fusion to different enzymes. Here, we review our current understanding of how the complexity of OB-fold-containing proteins and enzymes developed to expand their functions, especially in unicellular, pathogenic eukaryotes.
authors.affiliation: RNA Architecture and Reactivity, Strasbourg University, CNRS, IBMC, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Kapps
authors.affiliation: RNA Architecture and Reactivity, Strasbourg University, CNRS, IBMC, France.
authors.forename: Marta
authors.initials: M
authors.lastname: Cela
authors.affiliation: RNA Architecture and Reactivity, Strasbourg University, CNRS, IBMC, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Théobald-Dietrich
authors.affiliation: Department of Chemistry, Wayne State University, Detroit, MI, USA.
authors.forename: Tamara
authors.initials: T
authors.lastname: Hendrickson
authors.affiliation: RNA Architecture and Reactivity, Strasbourg University, CNRS, IBMC, France.
authors.forename: Magali
authors.initials: M
authors.lastname: Frugier
mesh_terms: D000818:Animals; D056890:Eukaryota / Q000378:metabolism*; D006801:Humans; D009841:Oligonucleotides / Q000378:metabolism*; D009844:Oligosaccharides / Q000378:metabolism*; D000072417:Protein Domains; D012343:RNA, Transfer / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D009841:Oligonucleotides; D009844:Oligosaccharides; D016601:RNA-Binding Proteins; D012343:RNA, Transfer
keywords: Trbp111; parasites; pathogenic eukaryotes; tRNA-binding protein