title: PicoGreen: a better amyloid probe than Thioflavin-T.
abstract: PicoGreen, a cyanine based ultrafast molecular rotor, shows high affinity towards amyloid fibrils and scores a much better sensitivity than Thioflavin-T, a gold standard probe for amyloid fibrils. Detailed spectroscopic and molecular docking studies have been performed to understand the mode of interaction between PicoGreen and amyloid fibrils.
authors.affiliation: Radiation & Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, India. snath@barc.gov.in sukhendunath@yahoo.co.in.
authors.forename: Aruna K
authors.initials: AK
authors.lastname: Mora
authors.affiliation: Radiation & Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, India. snath@barc.gov.in sukhendunath@yahoo.co.in.
authors.forename: Prabhat K
authors.initials: PK
authors.lastname: Singh
authors.affiliation: Bio-Organic Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, India.
authors.forename: Birija S
authors.initials: BS
authors.lastname: Patro
authors.affiliation: Radiation & Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, India. snath@barc.gov.in sukhendunath@yahoo.co.in.
authors.forename: Sukhendu
authors.initials: S
authors.lastname: Nath
mesh_terms: D000682:Amyloid / Q000737:chemistry*; D052160:Benzothiazoles; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D007328:Insulin / Q000737:chemistry*; D008958:Models, Molecular; D062105:Molecular Docking Simulation; D015335:Molecular Probes / Q000737:chemistry*; D009930:Organic Chemicals / Q000737:chemistry; D011485:Protein Binding; D013844:Thiazoles / Q000737:chemistry*
chemical_list: D000682:Amyloid; D052160:Benzothiazoles; D005456:Fluorescent Dyes; D007328:Insulin; D015335:Molecular Probes; D009930:Organic Chemicals; C099476:PicoGreen; D013844:Thiazoles; C009462:thioflavin T