title: Development and Characterization of VEGF165-Chitosan Nanoparticles for the Treatment of Radiation-Induced Skin Injury in Rats.
abstract: Radiation-induced skin injury, which remains a serious concern in radiation therapy, is currently believed to be the result of vascular endothelial cell injury and apoptosis. Here, we established a model of acute radiation-induced skin injury and compared the effect of different vascular growth factors on skin healing by observing the changes of microcirculation and cell apoptosis. Vascular endothelial growth factor (VEGF) was more effective at inhibiting apoptosis and preventing injury progression than other factors. A new strategy for improving the bioavailability of vascular growth factors was developed by loading VEGF with chitosan nanoparticles. The VEGF-chitosan nanoparticles showed a protective effect on vascular endothelial cells, improved the local microcirculation, and delayed the development of radioactive skin damage.
authors.affiliation: Department of Plastic Surgery, the Second Affiliated Hospital, Soochow University, Suzhou 215004, China. ydj51087@163.com.|Department of Pathology, School of Biology & Basic Medical Sciences, Soochow University, Suzhou 215123, China. ydj51087@163.com.
authors.forename: Daojiang
authors.initials: D
authors.lastname: Yu
authors.affiliation: College of Pharmaceutical Science, Soochow University, Suzhou 215123, China. m18862163651@163.com.
authors.forename: Shan
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Plastic Surgery, the Second Affiliated Hospital, Soochow University, Suzhou 215004, China. wsyy0514@163.com.
authors.forename: Shuai
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Plastic Surgery, the Second Affiliated Hospital, Soochow University, Suzhou 215004, China. 18362720093@163.com.
authors.forename: Xiujie
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Pathology, School of Biology & Basic Medical Sciences, Soochow University, Suzhou 215123, China. zhuminsheng714@126.com.
authors.forename: Minsheng
authors.initials: M
authors.lastname: Zhu
authors.affiliation: Department of Pathology, School of Biology & Basic Medical Sciences, Soochow University, Suzhou 215123, China. hshine1992@126.com.
authors.forename: Shai
authors.initials: S
authors.lastname: Huang
authors.affiliation: Department of Pathology, School of Biology & Basic Medical Sciences, Soochow University, Suzhou 215123, China. 20144221021@stu.suda.edu.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Sun
authors.affiliation: Department of Pathology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China. shengyongzh@163.com.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: College of Pharmaceutical Science, Soochow University, Suzhou 215123, China. liuyanli@suda.edu.cn.
authors.forename: Yanli
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Pathology, School of Biology & Basic Medical Sciences, Soochow University, Suzhou 215123, China. wangsoly112@hotmail.com.|Institute of Radiology & Oncology, Soochow University, Suzhou 215006, China. wangsoly112@hotmail.com.|Suzhou Key Laboratory of Tumor Microenvironment Pathology, Suzhou 215123, China. wangsoly112@hotmail.com.
authors.forename: Shouli
authors.initials: S
authors.lastname: Wang
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D048271:Chitosan; D004195:Disease Models, Animal; D008297:Male; D053758:Nanoparticles; D011833:Radiation Injuries, Experimental / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000098:blood supply / Q000528:radiation effects*; D042461:Vascular Endothelial Growth Factor A / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D042461:Vascular Endothelial Growth Factor A; D048271:Chitosan
keywords: VEGF; apoptosis; chitosan; nanoparticles; radiation-induced skin injury