title: High correlation of clinical criteria in the diagnosis of drug-resistant TB and prevalence of ofloxacin resistance.
abstract: To study the drug resistance profile of patients with suspected multidrug-resistant tuberculosis (MDR-TB).
  
  
  
  This was a prospective study conducted among patients with suspected MDR-TB attending the Department of Respiratory Medicine, King George's Medical University, Lucknow, India, from August 2014 to April 2015. Sputum samples obtained from 50 such patients were subjected to drug susceptibility testing against first- and second-line drugs. Data on baseline characteristics were obtained from the patients and their previous medical records.
  
  
  
  Mycobacterium tuberculosis was detected in 47/50 (94%) and non-tuberculous mycobacteria (NTM) in 3/50 (6%). Of the 47 patients with M. tuberculosis, 36 (76.6%) had MDR-TB: 24 (66.7%) of these had pre-extensively drug-resistant TB (pre-XDR-TB) and 4 (11.1%) had XDR-TB.
  
  
  
  Among proven MDR-TB cases, approximately two thirds were pre-XDR-TB cases and more than 10% were XDR-TB cases. These form a sizeable proportion and may result in the failure of second-line treatment.
authors.affiliation: Department of Respiratory Medicine, King George's Medical University, Lucknow, India.
authors.forename: R
authors.initials: R
authors.lastname: Kumar
authors.affiliation: Department of Respiratory Medicine, King George's Medical University, Lucknow, India.
authors.forename: R
authors.initials: R
authors.lastname: Garg
authors.affiliation: Department of Respiratory Medicine, King George's Medical University, Lucknow, India.
authors.forename: S
authors.initials: S
authors.lastname: Kant
authors.affiliation: Department of Respiratory Medicine, King George's Medical University, Lucknow, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Verma
authors.affiliation: Department of Respiratory Medicine, King George's Medical University, Lucknow, India.
authors.forename: R A S
authors.initials: RA
authors.lastname: Kushwaha
authors.affiliation: Department of Respiratory Medicine, King George's Medical University, Lucknow, India.
authors.forename: S
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Department of Microbiology, King George's Medical University, Lucknow, India.
authors.forename: A
authors.initials: A
authors.lastname: Jain
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D024901:Drug Resistance, Multiple, Bacterial; D054908:Extensively Drug-Resistant Tuberculosis / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000302:isolation & purification; D009170:Nontuberculous Mycobacteria / Q000187:drug effects / Q000302:isolation & purification; D015242:Ofloxacin / Q000627:therapeutic use*; D015995:Prevalence; D011446:Prospective Studies; D013183:Sputum / Q000382:microbiology; D018088:Tuberculosis, Multidrug-Resistant / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents; D015242:Ofloxacin