title: Theory of Acoustic Raman Modes in Proteins.
abstract: We present a theoretical analysis that associates the resonances of extraordinary acoustic Raman (EAR) spectroscopy [Wheaton et al., Nat. Photonics 9, 68 (2015)] with the collective modes of proteins. The theory uses the anisotropic elastic network model to find the protein acoustic modes, and calculates Raman intensity by treating the protein as a polarizable ellipsoid. Reasonable agreement is found between EAR spectra and our theory. Protein acoustic modes have been extensively studied theoretically to assess the role they play in protein function; this result suggests EAR spectroscopy as a new experimental tool for studies of protein acoustic modes.
authors.affiliation: Department of Electrical and Computer Engineering, University of Victoria, Victoria British Columbia V8P 5C2, Canada.
authors.forename: Timothy
authors.initials: T
authors.lastname: DeWolf
authors.affiliation: Department of Electrical and Computer Engineering, University of Victoria, Victoria British Columbia V8P 5C2, Canada.
authors.forename: Reuven
authors.initials: R
authors.lastname: Gordon
mesh_terms: D000162:Acoustics; D016880:Anisotropy; D008958:Models, Molecular; D011506:Proteins / Q000737:chemistry*; D013059:Spectrum Analysis, Raman / Q000379:methods*; D014732:Vibration
chemical_list: D011506:Proteins