title: A novel compartmentalised stent graft to isolate the perfusion of the abdominal organs.
abstract: Donation after cardiac death has been adopted to address the critical shortage of donor organs for transplant. Recovery of these organs is hindered by low blood flow that leads to permanent organ injury. We propose a novel approach to isolate the perfusion of the abdominal organs from the systemic malperfusion of the dying donor. We reasoned that this design could improve blood flow to organs without open surgery, while respecting the ethical principle that cardiac stress not be increased during organ recovery. Conditions within the stent were analysed using a computational fluid dynamics (CFD) method and validated on two prototypes in vitro. The hydrodynamic pressure drop across the stent was measured as 0.14-0.22 mmHg, which is a negligible influence. Device placement studies were also conducted on swine model fluoroscopically. All these results demonstrated the feasibility of rapidly isolating the perfusion to abdominal organs using a compartmentalised stent graft design.
authors.affiliation: a Department of Industrial Engineering , University of Pittsburgh , Pittsburgh , PA , USA.
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Chen
authors.affiliation: b Division of Vascular Surgery , University of Pittsburgh Medical Centre , Pittsburgh , PA , USA.|c Department of Surgery , University of Pittsburgh , Pittsburgh , PA , USA.|d McGowan Institute for Regenerative Medicine, University of Pittsburgh , Pittsburgh , PA , USA.
authors.forename: Bryan W
authors.initials: BW
authors.lastname: Tillman
authors.affiliation: e Department of Mechanical Engineering and Materials Science , University of Pittsburgh , Pittsburgh, Pittsburgh , PA , USA.
authors.forename: Sung Kwon
authors.initials: SK
authors.lastname: Cho
authors.affiliation: c Department of Surgery , University of Pittsburgh , Pittsburgh , PA , USA.
authors.forename: Tara D
authors.initials: TD
authors.lastname: Richards
authors.affiliation: c Department of Surgery , University of Pittsburgh , Pittsburgh , PA , USA.|f Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Centre , Pittsburgh , PA , USA.
authors.forename: Amit D
authors.initials: AD
authors.lastname: Tevar
authors.affiliation: d McGowan Institute for Regenerative Medicine, University of Pittsburgh , Pittsburgh , PA , USA.
authors.forename: Xinzhu
authors.initials: X
authors.lastname: Gu
authors.affiliation: c Department of Surgery , University of Pittsburgh , Pittsburgh , PA , USA.|d McGowan Institute for Regenerative Medicine, University of Pittsburgh , Pittsburgh , PA , USA.|g Department of Bioengineering , University of Pittsburgh , Pittsburgh , PA , USA.|h Department of Chemical and Petroleum Engineering , University of Pittsburgh , Pittsburgh , PA , USA.
authors.forename: William R
authors.initials: WR
authors.lastname: Wagner
authors.affiliation: a Department of Industrial Engineering , University of Pittsburgh , Pittsburgh , PA , USA.|d McGowan Institute for Regenerative Medicine, University of Pittsburgh , Pittsburgh , PA , USA.|g Department of Bioengineering , University of Pittsburgh , Pittsburgh , PA , USA.
authors.forename: Youngjae
authors.initials: Y
authors.lastname: Chun
mesh_terms: D000818:Animals; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D057446:Hydrodynamics; D008954:Models, Biological; D010477:Perfusion; D010865:Pilot Projects; D015607:Stents; D013552:Swine; D014019:Tissue Donors; D019737:Transplants / Q000502:physiology* / Q000601:surgery*
keywords: Organ donor; computational fluid dynamics; ischaemia; stent; transplant