title: Effect of Doxazosin on Autonomic Nervous Control and Urodynamics of Rat Urinary Bladder during Modeled Infravesical Obstruction.
abstract: The therapeutic effect of doxazosin (40 μg/kg/day over one month) on urinary bladder was examined in female rats with modeled chronic infravesical obstruction (IVO) produced by graduated mechanical constriction of the proximal urethral segment. In one month, IVO induced a pronounced vesical hypertrophy both in treated and untreated rats that manifested in increased bladder weight and capacity, the latter increment being pronouncedly greater in treated rats. In untreated IVO rats, infusion cystometry revealed elevated basal intravesical pressure of void bladder P0, markedly increased maximal (premicturitional) pressure Pmax, and increased amplitude of spontaneous oscillations of intravesical pressure ΔPdetin filled bladder. Doxazosin produced no significant effect on Pmaxrise during IVO, but prevented elevation of P0and increment of ΔPdetin filled bladder. During gradual filling of urinary bladder in control (intact) rats, the parasympathetic vesical influences increased progressively, while in untreated IVO rats, the adrenergic influences prevailed even at maximal filling of the bladder. In IVO rats, doxazosin prevented the bias of the sympathetic-parasympathetic balance in the filled bladder in favor of sympathetic influences, but did not prevent this bias in a void bladder. It is hypothesized that α-adrenoblockers improve micturition during IVO caused by benign prostatic hyperplasia not only by decreasing the urethral resistance to urine flow due to down-regulation of prostate smooth muscle tone, but also by a direct action of these blockers on detrusor adrenergic receptors and central structures involved in urinary bladder control.
authors.affiliation: Department of Experimental Modeling of Urological Diseases, N. Lopatkin Research Institute of Urology - Affiliated Branch of National Medical Research Radiology Centre, Ministry of Health of the Russian Federation, Moscow, Russia. vladkirp@yandex.ru.
authors.forename: V I
authors.initials: VI
authors.lastname: Kirpatovskii
authors.affiliation: Department of Experimental Modeling of Urological Diseases, N. Lopatkin Research Institute of Urology - Affiliated Branch of National Medical Research Radiology Centre, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: I S
authors.initials: IS
authors.lastname: Mudraya
authors.affiliation: Department of Experimental Modeling of Urological Diseases, N. Lopatkin Research Institute of Urology - Affiliated Branch of National Medical Research Radiology Centre, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Revenko
authors.affiliation: Department of Experimental Modeling of Urological Diseases, N. Lopatkin Research Institute of Urology - Affiliated Branch of National Medical Research Radiology Centre, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Bablumyan
authors.affiliation: Department of Experimental Modeling of Urological Diseases, N. Lopatkin Research Institute of Urology - Affiliated Branch of National Medical Research Radiology Centre, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: N K
authors.initials: NK
authors.lastname: Adamyan
authors.affiliation: Department of Experimental Modeling of Urological Diseases, N. Lopatkin Research Institute of Urology - Affiliated Branch of National Medical Research Radiology Centre, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: V P
authors.initials: VP
authors.lastname: Ivanov
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D017292:Doxazosin / Q000494:pharmacology* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011470:Prostatic Hyperplasia; D051381:Rats; D017779:Sympathetic Fibers, Postganglionic / Q000187:drug effects / Q000503:physiopathology; D014524:Urethral Obstruction / Q000188:drug therapy* / Q000503:physiopathology; D001743:Urinary Bladder / Q000187:drug effects / Q000294:innervation / Q000473:pathology; D014554:Urination / Q000187:drug effects*
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D017292:Doxazosin
keywords: bioimpedance harmonic analysis; infravesical obstruction; sympathetic-parasympathetic balance; urodynamics; α-adrenoblockers