title: Disease Centered Around Calcified Taenia solium Granuloma.
abstract: Taenia solium (the pork tapeworm) is present in most developing countries, where it is a frequent cause of seizures and other neurological disease. Parasitic larvae invade the human brain, establish, and eventually resolve, leaving a calcified scar. While these lesions are common in endemic regions, and most of these are clinically silent, a proportion of individuals with calcified cysticerci develop seizures from these lesions, and 30-65% of these cases are associated with perilesional edema (PE), likely due to host inflammation. This manuscript summarizes the importance, characteristics, natural history, and potential prevention and treatments of symptomatic calcified neurocysticercosis (NCC).
authors.affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
authors.forename: Theodore E
authors.initials: TE
authors.lastname: Nash
authors.affiliation: Unidad de Cisticercosis, Instituto Nacional de Ciencias Neurológicas, Lima, Peru. Electronic address: javier.bustos@jhu.edu.
authors.forename: Javier A
authors.initials: JA
authors.lastname: Bustos
authors.affiliation: Unidad de Cisticercosis, Instituto Nacional de Ciencias Neurológicas, Lima, Peru; Departamento de Ciencias Celulares y Moleculares, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru.
authors.forename: Hector H
authors.initials: HH
authors.lastname: Garcia
mesh_terms: D000818:Animals; D001921:Brain / Q000469:parasitology; D002114:Calcinosis / Q000150:complications* / Q000209:etiology; D004487:Edema / Q000209:etiology; D006099:Granuloma / Q000209:etiology*; D006801:Humans; D020019:Neurocysticercosis / Q000150:complications* / Q000469:parasitology; D012640:Seizures / Q000209:etiology* / Q000469:parasitology; D041201:Taenia solium / Q000502:physiology
keywords: calcified granuloma; epilepsy; neurocysticercosis; perilesional edema; seizures