title: Serum IL-10, MMP-7, MMP-9 Levels inHelicobacter pyloriInfection and Correlation with Degree of Gastritis.
abstract: OBJECTIVE
  Helicobacter pyloricauses gastric mucosal inflammation and immune reaction. However, the increase of IL-10, MMP-7, and MMP-7 levels in the serum is still controversial. The objective of this study was to investigate the serum levels of IL-10, MMP-7 & MMP-9 in gastritis patients withH. pyloriinfection.
  
  
  METHODS
  A cross-sectional study was done on seventy gastritis patients that consecutive admitted to endoscopy units. The diagnosis of gastritis was made based on histopathology and diagnosis ofH. pyloriinfection was based on rapid urease test. Serum samples were obtained to determine to circulate IL-10, MMP-7, and MMP-9 level. Univariate and bivariate analysis were done by SPSS version 22.
  
  
  RESULTS
  Forthy percentages of the patients were infected withH. pylori. The IL-10 level was significantly higher inH. pylori-infected patients compared to non-infected patients. However, there were no differences between serum levels of MMP-7 and MMP-9 in infected and non-infectedH. pyloripatients.
  
  
  CONCLUSIONS
  The immune response toH. pyloripromotes systemic inflammation, which was reflected by the increased levels of serum IL-10. However, there were no significant differences in MMP-7 and MMP-9 serum levels between positive and negative infectedH. pyloripatients.
authors.affiliation: University of Sumatera Utara, Gastroentero-Hepatology, Komp. Tasbi YY No 203, Medan, Sumatera Utara 20122, Indonesia.
authors.forename: Gontar
authors.initials: G
authors.lastname: Siregar
authors.affiliation: University of Sumatera Utara, Internal Medicine, Medan, Sumatera Utara, Indonesia.
authors.forename: Sahat
authors.initials: S
authors.lastname: Halim
authors.affiliation: University of Sumatera Utara, Internal Medicine, Medan, Sumatera Utara, Indonesia.
authors.forename: Ricky
authors.initials: R
authors.lastname: Sitepu
keywords: Helicobacter pylori; IL-10; MMP-7; MMP-9; gastritis