title: Superparamagnetic anisotropic nano-assemblies with longer blood circulation in vivo: a highly efficient drug delivery carrier for leukemia therapy.
abstract: Leukemia, unlike solid tumors, has no definite shape and spreads throughout the whole circulatory system, therefore the therapy of leukemia requires medication to stay longer in the circulatory system. Anisotropic nanoparticles, showing longer blood circulating life than that of isotropic nanoparticles reported in previous research, meet the demands of leukemia therapy. Based on this strategy, superparamagnetic anisotropic nano-assemblies (SANs) were fabricated and loaded with vincristine (VCR) to form VCR-SANs. When compared to the same dose of VCR-loaded isotropic nano-assemblies (SINs), the decrease in the leukocytes count and the positive expression ratio of CD13 in the VCR-SANs group were 19.38% and 16.4%, respectively, which indicated the improved anti-leukemia activity of the VCR-SANs. From the results of the pharmacokinetics study, the VCR-SANs remarkably held the amount of drug removed from the whole body per unit time half of the isotropic group and the concentration of drug in blood plasma against time was 2.1 times the isotropic group, demonstrating the rapid and sustained release behavior and longer blood circulation when combined with the results of in vivo tissue distribution studies. In summary, anisotropic nano-assemblies were found to be more promising than isotropic nano-assemblies via our in vivo and in vitro examinations.
authors.affiliation: State Key Laboratory of Bioelectronics, Jiangsu Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China. xiongfei@seu.edu.cn guning@seu.edu.cn.
authors.forename: Fei
authors.initials: F
authors.lastname: Xiong
authors.affiliation: State Key Laboratory of Bioelectronics, Jiangsu Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China. xiongfei@seu.edu.cn guning@seu.edu.cn.
authors.forename: Jilai
authors.initials: J
authors.lastname: Tian
authors.affiliation: State Key Laboratory of Bioelectronics, Jiangsu Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China. xiongfei@seu.edu.cn guning@seu.edu.cn.
authors.forename: Ke
authors.initials: K
authors.lastname: Hu
authors.affiliation: State Key Laboratory of Bioelectronics, Jiangsu Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China. xiongfei@seu.edu.cn guning@seu.edu.cn.
authors.forename: Xiawen
authors.initials: X
authors.lastname: Zheng
authors.affiliation: State Key Laboratory of Bioelectronics, Jiangsu Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China. xiongfei@seu.edu.cn guning@seu.edu.cn.
authors.forename: Jianfei
authors.initials: J
authors.lastname: Sun
authors.affiliation: China Pharmaceutical University, Nanjing, Jiangsu 210009, China.
authors.forename: Caiyun
authors.initials: C
authors.lastname: Yan
authors.affiliation: China Pharmaceutical University, Nanjing, Jiangsu 210009, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Yao
authors.affiliation: State Key Laboratory of Bioelectronics, Jiangsu Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China. xiongfei@seu.edu.cn guning@seu.edu.cn.
authors.forename: Lina
authors.initials: L
authors.lastname: Song
authors.affiliation: State Key Laboratory of Bioelectronics, Jiangsu Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China. xiongfei@seu.edu.cn guning@seu.edu.cn.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Bioelectronics, Jiangsu Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China. xiongfei@seu.edu.cn guning@seu.edu.cn.
authors.forename: Ning
authors.initials: N
authors.lastname: Gu
mesh_terms: D000818:Animals; D004337:Drug Carriers; D005290:Ferric Compounds; D006801:Humans; D020014:K562 Cells; D007938:Leukemia / Q000188:drug therapy*; D058185:Magnetite Nanoparticles; D051379:Mice; D014750:Vincristine / Q000008:administration & dosage*
chemical_list: D004337:Drug Carriers; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; C000499:ferric oxide; D014750:Vincristine