title: Oral pemphigus vulgaris: A case report with direct immunofluorescence study.
abstract: Pemphigus vulgaris (PV) is a chronic, autoimmune, intraepidermal blistering disease of the skin and mucous membranes. The initial clinical manifestation is frequently the development of intraoral lesions, and later, the lesions involve the other mucous membranes and skin. The etiology of this disease still remains obscure although the presence of autoantibodies is consistent with an autoimmune disease. These antibodies are targeted against the adhesion proteins of keratinocytes, leading to acantholysis (disruption of spinous layer, leading to intraepidermal clefting) and blister formation. Because only oral lesions are present initially, the chances of misdiagnosing the disease as another condition are increased, leading to inappropriate therapy. In this article, we report a case of PV with only oral manifestations in a 36-year-old male.
authors.affiliation: Department of Oral Pathology, SRM Dental College, Chennai, Tamil Nadu, India.
authors.forename: Sangeetha Jeevan
authors.initials: SJ
authors.lastname: Kumar
authors.affiliation: Department of Oral Medicine, SRM Dental College, Chennai, Tamil Nadu, India.
authors.forename: S P
authors.initials: SP
authors.lastname: Nehru Anand
authors.affiliation: Department of Oral Pathology, SRM Dental College, Chennai, Tamil Nadu, India.
authors.forename: Nandhini
authors.initials: N
authors.lastname: Gunasekaran
authors.affiliation: Department of Oral Pathology, SRM Dental College, Chennai, Tamil Nadu, India.
authors.forename: Rajkumar
authors.initials: R
authors.lastname: Krishnan
keywords: Autoantibodies; immunofluorescence; intra epithelial vesicle; pemphigus; ulceration