title: Feature Subset Selection for Cancer Classification Using Weight Local Modularity.
abstract: Microarray is recently becoming an important tool for profiling the global gene expression patterns of tissues. Gene selection is a popular technology for cancer classification that aims to identify a small number of informative genes from thousands of genes that may contribute to the occurrence of cancers to obtain a high predictive accuracy. This technique has been extensively studied in recent years. This study develops a novel feature selection (FS) method for gene subset selection by utilizing the Weight Local Modularity (WLM) in a complex network, called the WLMGS. In the proposed method, the discriminative power of gene subset is evaluated by using the weight local modularity of a weighted sample graph in the gene subset where the intra-class distance is small and the inter-class distance is large. A higher local modularity of the gene subset corresponds to a greater discriminative of the gene subset. With the use of forward search strategy, a more informative gene subset as a group can be selected for the classification process. Computational experiments show that the proposed algorithm can select a small subset of the predictive gene as a group while preserving classification accuracy.
authors.affiliation: School of Electronics and Information Engineering, Tongji University, Shanghai 201804, China.
authors.forename: Guodong
authors.initials: G
authors.lastname: Zhao
authors.affiliation: School of Electronics and Information Engineering, Tongji University, Shanghai 201804, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000379:methods; D030541:Databases, Genetic; D020869:Gene Expression Profiling / Q000379:methods*; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000145:classification* / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*