title: Embedding magnetic nanoparticles into coordination polymers to mimic zinc ion transporters for targeted tumor therapy.
abstract: Magnetic nanoparticle-embedded coordination polymers could act as mimics for zinc ion transporters for targeted cancer therapy. Compared with traditional zinc ionophores, our system could realize targeted and internal environment responsive transport of zinc ions to suppress the tumour growth while minimizing nonspecific injury to normal tissues.
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn and University of Chinese Academy of Sciences, Beijing, 100039, China.
authors.forename: Enguo
authors.initials: E
authors.lastname: Ju
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn.
authors.forename: Zhaowei
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn and University of Chinese Academy of Sciences, Beijing, 100039, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn.
authors.forename: Kai
authors.initials: K
authors.lastname: Dong
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn and University of Chinese Academy of Sciences, Beijing, 100039, China.
authors.forename: ZhenZhen
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn.
authors.forename: Fang
authors.initials: F
authors.lastname: Pu
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn.
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ren
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn.
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Qu
mesh_terms: D032701:Biomimetics; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy*; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D017136:Ion Transport / Q000187:drug effects; D008113:Liver Neoplasms / Q000188:drug therapy*; D058185:Magnetite Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D058990:Molecular Targeted Therapy; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D015032:Zinc / Q000378:metabolism*
chemical_list: D007473:Ion Channels; D058185:Magnetite Nanoparticles; D011108:Polymers; D015032:Zinc