title: Intermittent Hypoxia and Locomotor Training Enhances Dynamic but Not Standing Balance in Patients With Incomplete Spinal Cord Injury.
abstract: To test the effect of combined intermittent hypoxia (IH) and body weight-supported treadmill training (BWSTT) on standing and dynamic balance in persons with incomplete spinal cord injury (iSCI).
  
  
  
  Randomized, triple-blind, placebo-controlled study.
  
  
  
  Rehabilitation medical centers.
  
  
  
  Study participants (N=35) with chronic iSCI with American Spinal Injury Association grades C and D (>1y postinjury) were randomly assigned to either IH plus BWSTT (n=18) or continued normoxia (placebo) plus BWSTT protocol (n=17).
  
  
  
  Participants received either IH (alternating 1.5min 9% inspired O2with 1.5min 21% inspired O2, 15 cycles per day) or continued normoxia (21% O2) combined with 45 minutes of BWSTT for 5 consecutive days, followed by 3 times per week IH or normoxia plus BWSTT, for 3 additional weeks.
  
  
  
  Standing balance (normalized jerk and root-mean-square [RMS]) and dynamic balance (turning duration, cadence in a turn, and turn-to-sit duration) were assessed before and after IH and normoxia protocol by means of instrumented sway and instrumented timed Up and Go test.
  
  
  
  There was no significant difference in standing balance between interventions for both normalized jerk and RMS instrumented sway components (both P>.05). There was a significantly faster cadence (P<.001), turning duration (P<.001), and turn-to-sit duration (P=.001) in subjects receiving IH plus BWSTT, compared with placebo.
  
  
  
  A 4-week protocol of IH combined with locomotor training improves dynamic, but not standing, balance in persons with iSCI.
authors.affiliation: Chile Teletón Rehabilitation Institute, Santiago, Chile; Children's Hospital of Wisconsin, Milwaukee, WI. Electronic address: angela.navarrete-opazo@fulbrightmail.org.
authors.forename: Angela
authors.initials: A
authors.lastname: Navarrete-Opazo
authors.affiliation: Biology Department, University of Chile, Santiago, Chile.
authors.forename: Julio J
authors.initials: JJ
authors.lastname: Alcayaga
authors.affiliation: Hospital Mutual de Seguridad, Santiago, Chile.
authors.forename: Oscar
authors.initials: O
authors.lastname: Sepúlveda
authors.affiliation: Los Coihues Clinic, Santiago, Chile.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Varas
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D005684:Gait; D006801:Humans; D008297:Male; D008875:Middle Aged; D026741:Physical Therapy Modalities; D004856:Postural Balance / Q000502:physiology*; D020127:Recovery of Function; D013119:Spinal Cord Injuries / Q000534:rehabilitation*; D016138:Walking / Q000502:physiology*; D055815:Young Adult
keywords: Gait; Rehabilitation; Spinal cord injuries