title: Respiratory and Enteric Virus Detection in Children.
abstract: The majority of children with febrile seizures have viral infections and viruses were detected in 22% to 63% of children in published studies. Using molecular methods, viruses were also detected in asymptomatic persons. A prospective study was conducted to detect respiratory and enteric viruses in 192 children with febrile seizures and compare the detection rates to those found in 156 healthy age-matched controls. A respiratory or enteric virus was detected in 72.9% of children with febrile seizures and in 51.4% of healthy controls. The viruses most strongly associated with febrile seizures were influenza, respiratory syncytial virus, parainfluenza, human coronavirus, and rotavirus. Compared to healthy controls, the age-adjusted odds ratios for nasopharynx virus positivity in febrile seizure patients were 79.4, 2.8, 7.2, and 4.9 for influenza virus, parainfluenza virus, respiratory syncytial virus, and human coronavirus, respectively, and 22.0 for rotavirus in stool. The detected virus did not influence clinical features of febrile seizure.
authors.affiliation: 1 Department of Infectious Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia.
authors.forename: Marko
authors.initials: M
authors.lastname: Pokorn
authors.affiliation: 2 Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
authors.forename: Monika
authors.initials: M
authors.lastname: Jevšnik
authors.affiliation: 2 Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Petrovec
authors.affiliation: 2 Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
authors.forename: Andrej
authors.initials: A
authors.lastname: Steyer
authors.affiliation: 1 Department of Infectious Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Mrvič
authors.affiliation: 3 Department of Pediatric Surgery and Intensive Care, University Medical Centre Ljubljana, Ljubljana, Slovenia.
authors.forename: Štefan
authors.initials: Š
authors.lastname: Grosek
authors.affiliation: 4 Institute for Biostatistics and Medical Informatics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
authors.forename: Lara
authors.initials: L
authors.lastname: Lusa
authors.affiliation: 1 Department of Infectious Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia.
authors.forename: Franc
authors.initials: F
authors.lastname: Strle
mesh_terms: D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces / Q000821:virology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009305:Nasopharynx / Q000821:virology*; D016133:Polymerase Chain Reaction; D015995:Prevalence; D011446:Prospective Studies; D003294:Seizures, Febrile / Q000150:complications / Q000453:epidemiology / Q000628:therapy / Q000821:virology*; D014777:Virus Diseases / Q000150:complications / Q000453:epidemiology / Q000628:therapy / Q000821:virology*
keywords: human coronavirus; influenza virus; parainfluenza virus; respiratory syncytial virus; rotavirus