title: Factors influencing the fabrication of albumin-bound drug nanoparticles (ABDns): part I. Albumin-bound betulinic acid nanoparticles (ABBns).
abstract: Though there are many albumin-based drug delivery systems (ABDDS) in the market, it is not known whether ABDDS can be applied across all chemical classes. In this study, we applied ABDDS to a poorly water-soluble drug betulinic acid (BA) to improve its aqueous solubility. Monomeric albumin-bound BA (ABBns) nanoparticles can be fabricated in the range of 10-20 nm. BA self-assembled with HSA at 0.1:1 to 2:1 molar ratio within 0.5 h in phosphate buffer pH 7.4 and 8.4. Approximately, 85-90% BA could be loaded onto HSA in the presence of Tween 20 (T20) and sodium cholate (NaC). The release of BA from ABBns was linear over 5 days. In conclusion, for poorly water-soluble acidic drugs, a suitable solubiliser can release the drug from HSA binding site, depending on the aggregation number and affinity of the solubiliser for the HSA binding site.
authors.affiliation: a College of Pharmacy and Health Science , St. John's University , Queens , NY , USA.
authors.forename: Yochana
authors.initials: Y
authors.lastname: Srivari
authors.affiliation: a College of Pharmacy and Health Science , St. John's University , Queens , NY , USA.|b Division of Biopharmaceutics, Office of Pharmaceutical Quality, Office of New Drug Products , Center for Drug Evaluation and Research, Food and Drug Administration , Silver Spring , MD , USA.
authors.forename: Parnali
authors.initials: P
authors.lastname: Chatterjee
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000737:chemistry; D001665:Binding Sites; D002460:Cell Line; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D053978:Pentacyclic Triterpenes; D012709:Serum Albumin / Q000737:chemistry*; D012995:Solubility; D013499:Surface Properties; D014315:Triterpenes / Q000008:administration & dosage* / Q000737:chemistry; D014867:Water / Q000737:chemistry; D000094062:Betulinic Acid
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D053978:Pentacyclic Triterpenes; D012709:Serum Albumin; D014315:Triterpenes; D014867:Water; D000094062:Betulinic Acid
keywords: Betulinic acid; albumin; nanoparticles; solubilisers