title: Pigmy MicroRNA: surveillance cops in Therapies kingdom.
abstract: MicroRNAs (miRNAs) are well preserved in every animal. These pigmy sized non-coding RNAs (21-23 nt), scattered in genome, are responsible for micromanaging the versatile gene regulations. Involvement of miRNAs was surveillance cops in all human diseases including cardiovascular defects, tumor formation, reproductive pathways, and neurological and autoimmune disorders. The effective functional role of miRNA can be reduced by chemical entities of antisense oligonucleotides and versatile small molecules that support the views of novel therapy of different human diseases. In this study, we have updated our current understanding for designing and synthesizing miRNA-controlling therapeutic chemicals. We have also proposed variousin-vivodelivery strategies and their ongoing challenges to combat the incorporation hurdles in live cells and animals. Lastly, we have demonstrated the current progress of miRNA modulation in the treatment of different human diseases that provides an alternative approach of gene therapy.
authors.affiliation: Functional Genomics and Gene Silencing Group, Centre for Cellular and Molecular Biology (CSIR-CCMB), Uppal Road, Hyderabad - 500 007, India.
authors.forename: Utpal
authors.initials: U
authors.lastname: Bhadra
authors.affiliation: Functional Genomics and Gene Silencing Group, Centre for Cellular and Molecular Biology (CSIR-CCMB), Uppal Road, Hyderabad - 500 007, India.
authors.forename: Pradipta
authors.initials: P
authors.lastname: Patra
authors.affiliation: Functional Genomics and Gene Silencing Group, Centre for Cellular and Molecular Biology (CSIR-CCMB), Uppal Road, Hyderabad - 500 007, India.
authors.forename: Jagamohan
authors.initials: J
authors.lastname: Chhatai
authors.affiliation: Centre for Chemical Biology, Indian Institute of Chemical Technology (CSIR-IICT), Uppal Road, Hyderabad-500 007, India.
authors.forename: Manika
authors.initials: M
authors.lastname: Pal-Bhadra
keywords: autoimmune disorders; cardiovascular defects; microRNA; surveillance; tumor formation