title: Substrate Specificity of Na+,Cl-(HCO3-)-ATPase.
abstract: We studied substrate specificity of Na+,Cl-(HCO3-)-ATPase. In most cases, replacement of ATP for other phosphate-containing substances resulted in not only pronounced suppression of phosphohydrolase reactions, but also dramatic changes of their responsiveness to the stimulating effect of monovalent ions. The data showed that Na+,Cl-(HCO3-)-ATPase is a highly specific enzyme for ATP.
authors.affiliation: Research Institute of General Pathology and Pathological Physiology, Russian Academy of Sciences, Moscow, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Yurkiv
authors.affiliation: Research Institute of General Pathology and Pathological Physiology, Russian Academy of Sciences, Moscow, Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Melikhov
authors.affiliation: Research Institute of General Pathology and Pathological Physiology, Russian Academy of Sciences, Moscow, Russia. shubinvalerii@yandex.ru.
authors.forename: V S
authors.initials: VS
authors.lastname: Shubin
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism; D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D027963:Chloride-Bicarbonate Antiporters / Q000378:metabolism*; D003570:Cytidine Triphosphate / Q000378:metabolism; D011756:Diphosphates / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000378:metabolism; D011817:Rabbits; D013379:Substrate Specificity; D014544:Uridine Triphosphate / Q000378:metabolism
chemical_list: D000814:Aniline Compounds; D027963:Chloride-Bicarbonate Antiporters; D011756:Diphosphates; D009943:Organophosphorus Compounds; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D003570:Cytidine Triphosphate; C068798:4-aminophenylphosphate; D006160:Guanosine Triphosphate; D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases; C003319:sodium pyrophosphate; D014544:Uridine Triphosphate
keywords: CFTR protein; Na+,Cl–(HCO3 –)-ATPase; secretory process; small intestine