title: Association of DNA methyltransferase polymorphisms with susceptibility to primary gouty arthritis.
abstract: Gouty arthritis is the most common type of inflammatory and immune disease, and the prevalence and incidence of gout increases annually. Genetic variations in the DNA methyltransferases (DNMTs) gene have not, to the best of our knowledge, been reported to influence gene expression and to participate in the pathogenesis of gout. The aim of the present study was to investigate whether theDNMT1,DNMT3AandDNMT3Bpolymorphisms contribute to gout susceptibility. These polymorphisms were screened for in 336 gout patients and 306 healthy control subjects (from a South China population) for association with gout. The distribution frequencies ofDNMT1rs2228611 AA genotype (P=0.007) and A allele (P=0.002; odds ratio=1.508, 95% confidence interval=1.158-1.964) were found to be significantly increased in the gout patients when compared with those in the healthy control subjects. The rs1550117 inDNMT3Aand rs2424913 inDNMT3Bexhibited no significant associations with gout susceptibility between the patients and control subjects. These results demonstrated that theDNMT1rs2228611 polymorphism may be involved in the pathogenesis of gout, whileDNMT3Ars1550117 andDNMT3Brs2424913 did not show any obvious significance in the current study; thus, may not be used as risk factors to predict the susceptibility to gout. However, further studies are required to investigate the functions and regulatory mechanism of the polymorphisms ofDNMTsin gout.
authors.affiliation: Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China; Medicine Research Center, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China; Department of Laboratory Medicine, North Sichuan Medical College, Nanchong, Sichuan 637007, P.R. China.
authors.forename: Xiaowu
authors.initials: X
authors.lastname: Zhong
authors.affiliation: Department of Rheumatology and Immunology of the Affiliated Hospital, North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China.
authors.forename: Yuanhong
authors.initials: Y
authors.lastname: Peng
authors.affiliation: Medicine Research Center, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China.
authors.forename: Chengjiao
authors.initials: C
authors.lastname: Yao
authors.affiliation: Department of Rheumatology and Immunology of the Affiliated Hospital, North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Qing
authors.affiliation: Department of Rheumatology and Immunology of the Affiliated Hospital, North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China.
authors.forename: Qibin
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China; Department of Laboratory Medicine, North Sichuan Medical College, Nanchong, Sichuan 637007, P.R. China.
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China; Medicine Research Center, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China.
authors.forename: Wenguang
authors.initials: W
authors.lastname: Xie
authors.affiliation: Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China; Medicine Research Center, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China; Department of Laboratory Medicine, North Sichuan Medical College, Nanchong, Sichuan 637007, P.R. China.
authors.forename: Mingcai
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Department of Biology, North Sichuan Medical College, Nanchong, Sichuan 637007, P.R. China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Cai
authors.affiliation: Department of Laboratory Medicine, North Sichuan Medical College, Nanchong, Sichuan 637007, P.R. China; Department of Rheumatology and Immunology of the Affiliated Hospital, North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China.
authors.forename: Jing-Guo
authors.initials: JG
authors.lastname: Zhou
keywords: DNA methyltransferases; epigenetics; gouty arthritis; polymorphism