title: Electrophoresis separation assisted G-quadruplex DNAzyme-based chemiluminescence signal amplification strategy on a microchip platform for highly sensitive detection of microRNA.
abstract: We have developed an electrophoresis separation assisted G-quadruplex DNAzyme-based chemiluminescence (CL) signal amplification strategy on a microchip platform for the detection of trace microRNA. This strategy exhibits high sensitivity and specificity for detection of target molecules.
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004, China. zhaoshulin001@163.com jzhao12@163.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004, China. zhaoshulin001@163.com jzhao12@163.com.
authors.forename: Jingjin
authors.initials: J
authors.lastname: Zhao
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004, China. zhaoshulin001@163.com jzhao12@163.com.
authors.forename: Shuting
authors.initials: S
authors.lastname: Li
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004, China. zhaoshulin001@163.com jzhao12@163.com.
authors.forename: Liangliang
authors.initials: L
authors.lastname: Zhang
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004, China. zhaoshulin001@163.com jzhao12@163.com.
authors.forename: Yong
authors.initials: Y
authors.lastname: Huang
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004, China. zhaoshulin001@163.com jzhao12@163.com.
authors.forename: Shulin
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Department of Chemistry and Biochemistry, Jackson State University, 1400 Lynch St, Jackson, MS 39217, USA.
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Liu
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D021881:DNA, Catalytic / Q000378:metabolism*; D004586:Electrophoresis / Q000379:methods*; D054856:G-Quadruplexes; D056945:Hep G2 Cells; D006801:Humans; D008163:Luminescent Measurements / Q000379:methods*; D035683:MicroRNAs / Q000032:analysis* / Q000235:genetics / Q000302:isolation & purification; D046228:Microarray Analysis; D021141:Nucleic Acid Amplification Techniques / Q000379:methods*
chemical_list: D021881:DNA, Catalytic; D035683:MicroRNAs