title: IRGB10 Exposes Bacteria's Intimate Secrets.
abstract: When bacteria infect a cell, the bacterial membrane partially shields microbial structures from the immune system, preventing detection and clearance. In a recent issue of Cell, Man et al. (2016) show that the interferon-inducible protein IRGB10 liberates bacterial ligands for sensing by both the AIM2 and the non-canonical NLRP3 inflammasomes.
authors.affiliation: Institute of Innate Immunity, University Hospitals, University of Bonn, 53127 Bonn, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Hoss
authors.affiliation: Institute of Innate Immunity, University Hospitals, University of Bonn, 53127 Bonn, Germany.
authors.forename: Christina F
authors.initials: CF
authors.lastname: Budden
authors.affiliation: Institute of Innate Immunity, University Hospitals, University of Bonn, 53127 Bonn, Germany; Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01655, USA. Electronic address: eicke.latz@uni-bonn.de.
authors.forename: Eicke
authors.initials: E
authors.lastname: Latz
mesh_terms: D001419:Bacteria / Q000378:metabolism*; D058847:Inflammasomes / Q000276:immunology*
chemical_list: D058847:Inflammasomes