title: Role of Reactive Oxygen Species in Premature Ageing of the Female Reproductive Function.
abstract: Industrial xenobitics, as well as endogenous damaging factors, such as L-homocysteine, are a well-known source of reactive oxygen species that disrupt biological processes. Among many others, luteinizing hormone releasing hormone synthesis and secretion mediated by a variety of neurotransmitters, which are under control of the hypothalamus and pineal gland, may be put in peril by reactive oxygen species. Their formation can be one of the reasons for the reproductive function shutdown in ageing as the generic response to the damaging factors independent of their nature. We review recent findings demonstrating the role of reactive oxygen species in disrupting the circadian signal originated in the main pacemaker of the organism, the suprachiasmatic nuclei of the hypothalamus, on its way to the hypothalamic areas responsible for the luteinizing hormone preovulatory surge.
authors.forename: Andrew
authors.initials: A
authors.lastname: Korenevsky
authors.forename: Yulia
authors.initials: Y
authors.lastname: Milyutina
authors.forename: Ljudmila
authors.initials: L
authors.lastname: Kozina
authors.forename: Gleb
authors.initials: G
authors.lastname: Kerkeshko
authors.affiliation: Laboratory of Biochemistry, D.O. Ott Institute of Obstetrics, Gynecology, and Reproductology; 3, Mendeleyev Line, St. Petersburg, 199034, Russian Federation.
authors.forename: Alexander
authors.initials: A
authors.lastname: Arutjunyan
mesh_terms: D019588:Aging, Premature / Q000209:etiology* / Q000378:metabolism*; D000818:Animals; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000378:metabolism; D008550:Melatonin / Q000378:metabolism / Q000494:pharmacology; D018696:Neuroprotective Agents / Q000378:metabolism / Q000494:pharmacology; D009498:Neurotoxins / Q000378:metabolism / Q000633:toxicity; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012098:Reproduction / Q000187:drug effects / Q000502:physiology*
chemical_list: D018696:Neuroprotective Agents; D009498:Neurotoxins; D017382:Reactive Oxygen Species; D008550:Melatonin