title: Sources of Reactive Oxygen and Nitrogen Species in Tissue Microenvironment of Hernioplasty Materials.
abstract: Titanium and polypropylene mesh endoprostheses were implanted into the rat abdominal cavity and the populations of cells migrating to their surface were analyzed. On both materials, the cells were presented mainly by macrophages that proliferated, activated, and fused to form multinuclear cells. Contact with the foreign surface triggered superoxide anion generation and myeloperoxidase synthesis by macrophages (these processes were more intense on polypropylene implants than on titanium ones) and stimulated production of nitric oxide by macrophage. It was hypothesized that the effects of free nitrogen and oxygen radicals lead to oxidation and destruction of the polypropylene endoprosthesis surface.
authors.affiliation: Institute of Experimental Medicine and Biotechnologies, Samara State Medical University, the Ministry of Health of the Russian Federation, Samara, Russia.
authors.forename: N N
authors.initials: NN
authors.lastname: Sarbaeva
authors.affiliation: Institute of Experimental Medicine and Biotechnologies, Samara State Medical University, the Ministry of Health of the Russian Federation, Samara, Russia. jvponomareva@mail.ru.
authors.forename: Yu V
authors.initials: YV
authors.lastname: Ponomareva
authors.affiliation: Institute of Experimental Medicine and Biotechnologies, Samara State Medical University, the Ministry of Health of the Russian Federation, Samara, Russia.
authors.forename: M N
authors.initials: MN
authors.lastname: Milyakova
authors.affiliation: Institute of Experimental Medicine and Biotechnologies, Samara State Medical University, the Ministry of Health of the Russian Federation, Samara, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Gribkova
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D002448:Cell Adhesion; D005260:Female; D059685:Herniorrhaphy; D020007:Implants, Experimental; D008264:Macrophages / Q000201:enzymology; D008297:Male; D008422:Materials Testing; D009504:Neutrophils / Q000201:enzymology; D009195:Peroxidase / Q000378:metabolism; D011126:Polypropylenes / Q000276:immunology; D051381:Rats; D026361:Reactive Nitrogen Species / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013526:Surgical Mesh; D014025:Titanium / Q000276:immunology
chemical_list: D011126:Polypropylenes; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D014025:Titanium; D009195:Peroxidase
keywords: endoprosthesis; free radicals; hernioplasty; macrophage