title: The cell biology of late blight disease.
abstract: Late blight, caused by the oomycete Phytophthora infestans, is a major global disease of potato and tomato. Cell biology is teaching us much about the developmental stages associated with infection, especially the haustorium, which is a site of intimate interaction and molecular exchange between pathogen and host. Recent observations suggest a role for the plant endocytic cycle in specific recruitment of host proteins to the Extra-Haustorial Membrane, emphasising the unique nature of this membrane compartment. In addition, there has been a strong focus on the activities of RXLR effectors, which are delivered into plant cells to modulate and manipulate host processes. RXLR effectors interact directly with diverse plant proteins at a range of subcellular locations to promote disease.
authors.affiliation: Cell and Molecular Sciences, James Hutton Institute, Errol Road, Invergowrie, Dundee DD2 5DA, UK.
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Whisson
authors.affiliation: Cell and Molecular Sciences, James Hutton Institute, Errol Road, Invergowrie, Dundee DD2 5DA, UK.
authors.forename: Petra C
authors.initials: PC
authors.lastname: Boevink
authors.affiliation: Division of Plant Sciences, University of Dundee, James Hutton Institute, Invergowrie, Dundee DD2 5DA, UK.
authors.forename: Shumei
authors.initials: S
authors.lastname: Wang
authors.affiliation: Cell and Molecular Sciences, James Hutton Institute, Errol Road, Invergowrie, Dundee DD2 5DA, UK; Division of Plant Sciences, University of Dundee, James Hutton Institute, Invergowrie, Dundee DD2 5DA, UK. Electronic address: Paul.Birch@hutton.ac.uk.
authors.forename: Paul Rj
authors.initials: PR
authors.lastname: Birch
mesh_terms: D054884:Host-Pathogen Interactions; D018551:Solanum lycopersicum / Q000382:microbiology; D055750:Phytophthora infestans / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity / Q000502:physiology*; D010935:Plant Diseases / Q000382:microbiology*; D018515:Plant Leaves / Q000382:microbiology / Q000502:physiology; D010940:Plant Proteins / Q000378:metabolism*; D011198:Solanum tuberosum / Q000382:microbiology; D014774:Virulence
chemical_list: D010940:Plant Proteins