title: Is quantitative coronary angiography reliable in assessing the lumen gain after treatment with the everolimus-eluting bioresorbable polylactide scaffold?
abstract: OBJECTIVE
  The current study aimed to assess the difference in lumen dimension measurements between optical coherence tomography (OCT) and quantitative coronary angiography (QCA) in the polymeric bioresorbable scaffold and metallic stent.
  
  
  RESULTS
  In the randomised ABSORB Japan trial, 87 lesions in the Absorb arm and 44 lesions in the XIENCE arm were analysed. Post-procedural OCT-QCA lumen dimensions were assessed in matched proximal/distal non-stented/non-scaffolded reference (n=199), scaffolded (n=145) and stented (n=75) cross-sections at the two device edges using the Bland-Altman method. In the non-stented/non-scaffolded reference segments, QCA systematically underestimated lumen diameter (LD) compared with OCT (accuracy, -0.26 mm; precision, 0.47 mm; 95% limits of agreement as a mean bias±1.96 standard deviation, -1.18-0.66 mm). When compared to OCT, QCA of the Absorb led to a more severe underestimation of the LD (-0.30 mm; 0.39 mm; -1.06-0.46 mm) than with the XIENCE (-0.14 mm; 0.31 mm; -0.75-0.46 mm). QCA underestimated LD by 9.1%, 4.9%, and 9.8% in the reference, stented, and scaffolded segments, respectively. The protrusion distance of struts was larger in the Absorb arm than in the XIENCE arm (135±27 µm vs. 18±26 µm, p<0.001), and may have contributed to the observed differences.
  
  
  CONCLUSIONS
  In-device QCA measurement was differently affected by the presence of a metallic or polymeric scaffold, a fact that had a significant impact on the QCA assessment of acute gain and post-procedural minimum LD.
authors.affiliation: Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Sotomi
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Onuma
authors.forename: Pannipa
authors.initials: P
authors.lastname: Suwannasom
authors.forename: Hiroki
authors.initials: H
authors.lastname: Tateishi
authors.forename: Erhan
authors.initials: E
authors.lastname: Tenekecioglu
authors.forename: Yaping
authors.initials: Y
authors.lastname: Zeng
authors.forename: Rafael
authors.initials: R
authors.lastname: Cavalcante
authors.forename: Hans
authors.initials: H
authors.lastname: Jonker
authors.forename: Jouke
authors.initials: J
authors.lastname: Dijkstra
authors.forename: Nicolas
authors.initials: N
authors.lastname: Foin
authors.forename: Jaryl Ng Chen
authors.initials: JN
authors.lastname: Koon
authors.forename: Carlos
authors.initials: C
authors.lastname: Collet
authors.forename: Robbert J
authors.initials: RJ
authors.lastname: de Winter
authors.forename: Joanna J
authors.initials: JJ
authors.lastname: Wykrzykowska
authors.forename: Gregg W
authors.initials: GW
authors.lastname: Stone
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Popma
authors.forename: Ken
authors.initials: K
authors.lastname: Kozuma
authors.forename: Kengo
authors.initials: K
authors.lastname: Tanabe
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Serruys
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kimura
mesh_terms: D020341:Absorbable Implants; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000601:surgery*; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D054855:Drug-Eluting Stents; D000068338:Everolimus / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011091:Polyesters; D011474:Prosthesis Design; D016032:Randomized Controlled Trials as Topic; D016037:Single-Blind Method; D054457:Tissue Scaffolds; D041623:Tomography, Optical Coherence / Q000379:methods; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D011091:Polyesters; C033616:poly(lactide); D000068338:Everolimus