title: β-Nicotinamide Mononucleotide, an Anti-Aging Candidate Compound, Is Retained in the Body for Longer than Nicotinamide in Rats.
abstract: The turnover of the oxidized form of nicotinamide adenine dinucleotide (NAD+) has attracted interest in regard to longevity. Thus, compounds that can rapidly increase the cellular NAD+concentration have been surveyed by many researchers. Of those, β-nicotinamide mononucleotide (β-NMN) has been focused on. Studies on the biosynthesis of NAD+from β-NMN have been reported at the cellular level, but not at the whole animal level. In the present study, we investigated whether β-NMN is superior to nicotinamide (Nam) as a precursor of NAD+in whole animal experiments. To this end we compared the NAD+concentration in the blood and the urinary excretion amounts of NAD+catabolites. Rats were intraperitoneally injected with β-NMN or Nam. After the injection, blood samples and urine samples were collected at 3-h intervals. The concentration of blood total NAD (NAD11NADH) in each sample showed no significant differences between the two groups. The urinary excretion amounts of NAD+catabolites in the urine samples collected at 3-6 h after the injection were lower in the β-NMN group than in the Nam group. These results suggest that β-NMN is retained in the body for longer than Nam.
authors.affiliation: Department of Nutrition, School of Human Cultures, The University of Shiga Prefecture.
authors.forename: Tomoyo
authors.initials: T
authors.lastname: Kawamura
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Mori
authors.forename: Katsumi
authors.initials: K
authors.lastname: Shibata
mesh_terms: D000375:Aging; D000818:Animals; D007274:Injections, Intraperitoneal; D008136:Longevity; D008297:Male; D009243:NAD / Q000097:blood / Q000652:urine; D009536:Niacinamide / Q000493:pharmacokinetics*; D009537:Nicotinamide Mononucleotide / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D009243:NAD; D009537:Nicotinamide Mononucleotide; D009536:Niacinamide