title: Blood lipid abnormality changes the rate of alveolar-capillary uptake of sevoflurane: a prospective, non-interventional, clinical study .
abstract: OBJECTIVE
  This research studied the influence of different blood lipid components on the rate of alveolar-capillary uptake of sevoflurane.Method:104 patients aged 20 - 50 years undergoing elective operations under general anesthesia were mechanically ventilated through endotracheal intubation after intravenous injections of midazolam, vecuronium, fentanyl, and etomidate. They inhaled 2% sevoflurane at an oxygen flow of 2 L/min, then the inspired concentrations (FI) and expired concentrations (FAof sevoflurane were recorded at 1, 3, 5, 7, 10, 15, 20, and 30 minutes. These cases were divided into a normal group and an abnormal group according to the lipid levels. Then, based on the lipid criteria, those cases with abnormal lipid levels were classified into a high-triglyceride (TG) and total-cholesterol (TC) group (group TG+TC) and a group with decreased high-density lipoprotein cholesterol (group HDL-C).The values of FA/FIand the times required to reach the titration value FA/FI= 0.8 were calculated were calculated for each group.
  
  
  RESULTS
  Compared with the normal group, FA/FIdecreased within 7 - 10 minutes (p < 0.05) and the time taken to reach the titration value was prolonged in the abnormal group (p < 0.05). The value of FA/FIdecreased during 7 - 10 minutes (p < 0.05) and the time taken to reach the titration value was longer (p < 0.05) in the group TG+TC.
  
  
  CONCLUSIONS
  The increased value of blood/gas partition coefficients (B/G) was caused by the increase in the concentrations of TG and TC in blood lipids. .
authors.forename: YanQiu
authors.initials: Y
authors.lastname: Liu
authors.forename: YiMin
authors.initials: Y
authors.lastname: Ren
authors.forename: Hong
authors.initials: H
authors.lastname: Gao
authors.forename: Li
authors.initials: L
authors.lastname: Zeng
authors.forename: ShaoFeng
authors.initials: S
authors.lastname: Lin
authors.forename: KaiQiang
authors.initials: K
authors.lastname: Zhang
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D015415:Biomarkers / Q000097:blood; D015824:Blood-Air Barrier / Q000378:metabolism*; D002199:Capillary Permeability; D050171:Dyslipidemias / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008875:Middle Aged; D011446:Prospective Studies; D000077149:Sevoflurane; D055815:Young Adult
chemical_list: D018685:Anesthetics, Inhalation; D015415:Biomarkers; D008055:Lipids; D008738:Methyl Ethers; D000077149:Sevoflurane