title: Organization of the axon initial segment: Actin like a fence.
abstract: What prevents the movement of membrane molecules between axonal and somatodendritic domains is unclear. In this issue, Albrecht et. al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603108) demonstrate via high-speed single-particle tracking and superresolution microscopy that lipid-anchored molecules in the axon initial segment are confined to membrane domains separated by periodically spaced actin rings.
authors.affiliation: Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030.
authors.forename: Yu-Mei
authors.initials: YM
authors.lastname: Huang
authors.affiliation: Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030 rasband@bcm.edu.
authors.forename: Matthew N
authors.initials: MN
authors.lastname: Rasband
mesh_terms: D000199:Actins / Q000378:metabolism*; D000071040:Axon Initial Segment / Q000378:metabolism*; D004058:Diffusion; D008565:Membrane Proteins / Q000378:metabolism; D008954:Models, Biological
chemical_list: D000199:Actins; D008565:Membrane Proteins