title: Association of interleukin 16 gene polymorphisms and plasma IL16 level with osteosarcoma risk.
abstract: Interleukin (IL) 16 plays a key role in inflammatory diseases as well as in tumorigenesis of osteosarcoma (OS). The aim of this study was to investigate the association of IL16 polymorphisms and plasma IL16 level with OS risk in a Chinese population. We genotyped IL16 rs4778889, rs11556218, and rs4072111 in 358 patients with OS and 402 controls using a polymerase chain reaction-restriction fragment length polymorphism assay. Plasma IL16 level was measured by enzyme-linked immunosorbent assay. Rs11556218 was associated with an increased risk of OS in heterozygote comparison (adjusted OR = 1.65, 95% CI, 1.23-2.21, P < 0.001), dominant model (adjusted OR = 1.66, 95% CI, 1.24-2.21, P < 0.001), and allele comparison (adjusted OR = 1.44, 95% CI, 1.14-1.81, P = 0.002). Moreover, rs11556218 TG/GG genotypes were associated with higher levels of IL16 as compared to TT genotype (P = 0.03). However, no significant association of rs4778889 and rs4072111 and OS was found. These findings suggest that rs11556218 TG/GG genotypes may be associated with increased susceptibility to OS, probably by increasing the production of IL16 level.
authors.affiliation: Department of Orthopedic Surgery, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, Guangxi, China.
authors.forename: Yu-Jin
authors.initials: YJ
authors.lastname: Tang
authors.affiliation: Department of Orthopedic Surgery, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, Guangxi, China.
authors.forename: Jun-Li
authors.initials: JL
authors.lastname: Wang
authors.affiliation: Department of Orthopedic Surgery, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, Guangxi, China.
authors.forename: Ke-Gong
authors.initials: KG
authors.lastname: Xie
authors.affiliation: Department of Orthopedic Surgery, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, Guangxi, China.
authors.forename: Chang-Gong
authors.initials: CG
authors.lastname: Lan
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D001859:Bone Neoplasms / Q000097:blood / Q000235:genetics; D002648:Child; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D019410:Interleukin-16 / Q000097:blood / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood / Q000235:genetics; D012516:Osteosarcoma / Q000097:blood / Q000235:genetics; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D019410:Interleukin-16; D009363:Neoplasm Proteins