title: Relationship between oxysterols and mild cognitive impairment in the elderly: a case-control study.
abstract: BACKGROUND
  To investigate the relationship between oxysterols and mild cognitive impairment (MCI) in a matched case-control study.
  
  
  METHODS
  The plasma levels of four oxysterols, 27-hydroxycholesterol (27-OHC), 24S-hydroxycholesterol (24S-OHC), 7α-hydroxycholesterol (7α-OHC) and 7β-hydroxycholesterol (7β-OHC), were analyzed by High Performance Liquid Chromatography-Mass Spectrometry (HPLC-MS) and compared between 70 MCI patients and 140 matched controls with normal cognition. The odds ratio (OR) was calculated using logistic analyses to assess the association between oxysterols and MCI.
  
  
  RESULTS
  Compared with controls with normal cognition, plasma level of 27-OHC was significantly higher in MCI patients. Logistic analyses suggested high plasma level of 27-OHC was significantly associated with MCI even after multivariate adjustment (OR = 2.86, 95 % CI: 1.52 ~ 5.37).
  
  
  CONCLUSIONS
  Our findings suggested that the increased plasma level of 27-OHC was associated with MCI, suggesting high plasma levels of 27-OHC may pay an important role in the development of MCI.
authors.affiliation: School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, No.10 Xitoutiao, You An Men Wai, Beijing, 100069, Fengtai District, China.
authors.forename: Quanri
authors.initials: Q
authors.lastname: Liu
authors.affiliation: School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, No.10 Xitoutiao, You An Men Wai, Beijing, 100069, Fengtai District, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: An
authors.affiliation: School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, No.10 Xitoutiao, You An Men Wai, Beijing, 100069, Fengtai District, China.
authors.forename: Huanling
authors.initials: H
authors.lastname: Yu
authors.affiliation: School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, No.10 Xitoutiao, You An Men Wai, Beijing, 100069, Fengtai District, China.
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Lu
authors.affiliation: School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, No.10 Xitoutiao, You An Men Wai, Beijing, 100069, Fengtai District, China.
authors.forename: Lingli
authors.initials: L
authors.lastname: Feng
authors.affiliation: School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, No.10 Xitoutiao, You An Men Wai, Beijing, 100069, Fengtai District, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.affiliation: School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, No.10 Xitoutiao, You An Men Wai, Beijing, 100069, Fengtai District, China. xiaor22@ccmu.edu.cn.
authors.forename: Rong
authors.initials: R
authors.lastname: Xiao
mesh_terms: D000368:Aged; D000544:Alzheimer Disease; D002851:Chromatography, High Pressure Liquid; D060825:Cognitive Dysfunction / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D006888:Hydroxycholesterols / Q000097:blood*; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged
chemical_list: D006888:Hydroxycholesterols; C044563:24-hydroxycholesterol; C076996:27-hydroxycholesterol
keywords: 27–hydroxycholesterol; Alzheimer’s disease; Aβ1-40; Aβ1-42; Mild cognitive impairment; MoCA; Oxysterols