title: The evaluation of endothelial function and structure in hirsute patients in reproductive age.
abstract: OBJECTIVE
  To evaluate the endothelial function and structure in patients with hirsutism in reproductive age.
  
  
  METHODS
  The study was conducted on 69 consecutive women admitted with complaints of hirsutism and 63 voluntary healthy women, as controls. A total of 132 subjects who applied to the Gynecology and Infertility Outpatient Clinics were included. Participants with modified Ferriman Gallway (mFG) score over 8 were considered to be hirsute. The demographic, metabolic, hormonal characteristics, risk factors of cardiovascular disease, CIMT (carotis intima media thickness) and FMD (flow-mediated dilatation) were compared between hirsute women and those in the control group. A prospective case-control study was performed.
  
  
  RESULTS
  There was no statistically significant difference in CIMT (0,50±0,08 vs 0,52±0,08, p=0.38) and FMD (10,80±6,83 vs 9,57±6,52, p=0.34) values between the study and control groups, respectively. There was no statistically significant correleation between CIMT and FMD values with age, body mass index (BMI), waist circumference, hip circumference, waist/hip ratio, CRP (C-reactive protein), total cholesterol, LDL (low density lipoprotein), HDL (high density lipoprotein), total testosteron, FAI (free androjen index), androstenedion, SHBG (sex hormone binding globuline), DHEA-S, hirsutism score, sistolic blood pressure, diastolic blood pressure, HOMA-IR (homeostatic model of assesment insuline resistance) value.
  
  
  CONCLUSIONS
  The effect of the presence of hirsutism on either CIMT and FMD values, among young patients was not significant. Since endothelial dysfunction might became evident after a long period of physio-pathological process, our findings obtained from younger patients may not really show the impact of hirsutism on endothelial function in short term.
authors.affiliation: Marmara University Hospital, Department of Obstetrics and Gynecology, Fevzi Cakmak District, Muhsin Yazicioglu Street No. 10, Ust Kaynarca, Pendik, Istanbul, Turkey.
authors.forename: Kemal
authors.initials: K
authors.lastname: Atasayan
authors.affiliation: Marmara University Hospital, Department of Obstetrics and Gynecology, Fevzi Cakmak District, Muhsin Yazicioglu Street No. 10, Ust Kaynarca, Pendik, Istanbul, Turkey. Electronic address: tevfik.yoldemir@gmail.com.
authors.forename: Tevfik
authors.initials: T
authors.lastname: Yoldemir
authors.affiliation: Marmara University Hospital, Department of Obstetrics and Gynecology, Fevzi Cakmak District, Muhsin Yazicioglu Street No. 10, Ust Kaynarca, Pendik, Istanbul, Turkey.
authors.forename: Sedef
authors.initials: S
authors.lastname: Ramoglu
authors.affiliation: Marmara University Hospital, Department of Internal Medicine, Fevzi Cakmak District, Muhsin Yazicioglu Street No. 10, Ust Kaynarca, Pendik, Istanbul, Turkey.
authors.forename: Dilek Gogas
authors.initials: DG
authors.lastname: Yavuz
mesh_terms: D000293:Adolescent; D000328:Adult; D000728:Androgens / Q000097:blood; D015992:Body Mass Index; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006628:Hirsutism / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D010053:Ovary / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011446:Prospective Studies; D014463:Ultrasonography; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: D000728:Androgens
keywords: CIMT; Carotis intima media thickness; Endothelial dysfunction; FMD; Flow mediated dilatation; Hirsutism