title: Resveratrol more effectively than quercetin reduces endothelium degeneration and level of necrosis factor α in patients with coronary artery disease.
abstract: BACKGROUND
  endothelial dysfunction (ED) is one of the most important links in the pathogenesis of atherosclerosis (ASVD) - morphological basis of coronary artery disease (CAD).
  
  
  OBJECTIVE
  to study the effect of polyphenolic antioxidants, resveratrol and quercetin, on endothelial degeneration factors in CAD patients.
  
  
  METHODS
  the study involved 93 patients with coronary artery disease: stable angina pectoris, FC II. The cytofluorometric technique was applied to define the level of circulating endothelial microparticles (EMP) CD32+CD40+ in peripheral blood in order to identify ED. The content of tumor necrosis factor α (TNF-α), fibrinogen, hemocoagulation and lipid profile parameters were being determined in the blood, as well. Patients were divided into 3 groups. Basic therapy (β-blockers, statins, aspirin) was prescribed to 33 persons of the comparison group, patients of the study group 1 (30 persons) additionally received resveratrol at a dose of 100 mg daily, patients of the study group 2 (30 persons) got quercetin at a dose of 3 g per day. In 2 months, the second examination of the patients was performed in the amount indicated.
  
  
  RESULTS
  under the influence of resveratrol a significant reduction of the level of TNF-α and the number of EMP in peripheral blood was shown, in contrast to the results of other study groups. All groups showed a decrease in total cholesterol and low-density lipoprotein cholesterol, statistical differences between data of groups were not found. Indicators of coagulogramma in all study groups did not change significantly, however, there was a statistically significant reduction of fibrinogen in the blood.
  
  
  CONCLUSIONS
  resveratrol, unlike quercetin, has a positive effect on the endothelial function and systemic inflammation, which may be the result of its influence on intracellular molecular cascades associated with the nuclear transcription factor of NF-kB.
authors.affiliation: Higher State Educational Establishment of Ukraine, "Ukrainian Medical Stomatological Academy", Poltava, Ukraine, e-mail: chekalina.ni.med@mail.ru.
authors.forename: Natalia I
authors.initials: NI
authors.lastname: Chekalina
authors.affiliation: Higher State Educational Establishment of Ukraine, "Ukrainian Medical Stomatological Academy", Poltava, Ukraine.
authors.forename: Yuri M
authors.initials: YM
authors.lastname: Kazakov
authors.affiliation: Higher State Educational Establishment of Ukraine, "Ukrainian Medical Stomatological Academy", Poltava, Ukraine.
authors.forename: Tatyana V
authors.initials: TV
authors.lastname: Mamontova
authors.affiliation: Higher State Educational Establishment of Ukraine, "Ukrainian Medical Stomatological Academy", Poltava, Ukraine.
authors.forename: Ludmila E
authors.initials: LE
authors.lastname: Vesnina
authors.affiliation: Higher State Educational Establishment of Ukraine, "Ukrainian Medical Stomatological Academy", Poltava, Ukraine.
authors.forename: Igor P
authors.initials: IP
authors.lastname: Kaidashev
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000494:pharmacology; D050197:Atherosclerosis; D003324:Coronary Artery Disease / Q000188:drug therapy* / Q000473:pathology; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000473:pathology; D005260:Female; D005340:Fibrinogen / Q000187:drug effects; D006801:Humans; D007249:Inflammation; D008077:Lipoproteins, LDL / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D011794:Quercetin / Q000494:pharmacology* / Q000627:therapeutic use; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology* / Q000627:therapeutic use; D014409:Tumor Necrosis Factor-alpha / Q000187:drug effects
chemical_list: D000975:Antioxidants; D008077:Lipoproteins, LDL; D013267:Stilbenes; D014409:Tumor Necrosis Factor-alpha; D005340:Fibrinogen; D011794:Quercetin; D000077185:Resveratrol
keywords: circulating endothelial microparticles; coronary artery disease; endothelial dysfunction; quercetin; resveratrol