title: Nebraska Red: a phosphinate-based near-infrared fluorophore scaffold for chemical biology applications.
abstract: A series of novel phosphinate-based dyes displaying near-infrared fluorescence (NIR) are reported. These dyes exhibit remarkable photostability and brightness. The phosphinate functionality is leveraged as an additional reactive handle in order to tune cell permeability as well as provide a proof-of-principle for a self-reporting small molecule delivery vehicle.
authors.affiliation: Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. cstains2@unl.edu.
authors.forename: Xinqi
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. cstains2@unl.edu and Nebraska Center for Materials and Nanoscience, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
authors.forename: Rui
authors.initials: R
authors.lastname: Lai
authors.affiliation: Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. cstains2@unl.edu.
authors.forename: Jon R
authors.initials: JR
authors.lastname: Beck
authors.affiliation: Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. cstains2@unl.edu and Nebraska Center for Materials and Nanoscience, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. cstains2@unl.edu.
authors.forename: Cliff I
authors.initials: CI
authors.lastname: Stains
mesh_terms: D002463:Cell Membrane Permeability; D016503:Drug Delivery Systems; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry; D010721:Phosphinic Acids / Q000737:chemistry*; D026361:Reactive Nitrogen Species / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D019265:Spectroscopy, Near-Infrared / Q000379:methods*
chemical_list: D005456:Fluorescent Dyes; D010721:Phosphinic Acids; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species