title: Characteristics of HLA-E Restricted T-Cell Responses and Their Role in Infectious Diseases.
abstract: Human HLA-E can, in addition to self-antigens, also present pathogen-derived sequences, which elicit specific T-cell responses. T-cells recognize their antigen presented by HLA-E highly specifically and have unique functional and phenotypical properties. Pathogen specific HLA-E restricted CD8+T-cells are an interesting new player in the field of immunology. Future work should address their exact roles and relative contributions in the immune response against infectious diseases.
authors.affiliation: Department of Infectious Diseases, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
authors.forename: Simone A
authors.identifier: 0000-0002-9878-0863
authors.initials: SA
authors.lastname: Joosten
authors.affiliation: Department of Microbiology and Immunology, The University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3010, Australia.
authors.forename: Lucy C
authors.identifier: 0000-0003-2907-4989
authors.initials: LC
authors.lastname: Sullivan
authors.affiliation: Department of Infectious Diseases, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
authors.forename: Tom H M
authors.initials: TH
authors.lastname: Ottenhoff
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D000941:Antigens / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D003141:Communicable Diseases / Q000209:etiology* / Q000378:metabolism; D018984:Epitopes, T-Lymphocyte / Q000276:immunology* / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D011485:Protein Binding; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D000097625:HLA-E Antigens
chemical_list: D000941:Antigens; D018984:Epitopes, T-Lymphocyte; D015395:Histocompatibility Antigens Class I; D011948:Receptors, Antigen, T-Cell; D000097625:HLA-E Antigens