title: Good Biocompatibility and Sintering Properties of Zirconia Nanoparticles Synthesized via Vapor-phase Hydrolysis.
abstract: ZrO2nanoparticles were synthesized by a vapor-phase hydrolysis process, and characterized in terms of crystalline structures, hardness and microstructures by X-ray diffraction, Vickers hardness test method, and atomic force microscopy (AFM) measurements. Moreover, in vitro cytotoxicity evaluation and hemolysis assay showed that the nanoparticles possessed good biocompatibility. Hardness investigations and AFM measurements indicated that both the sintering temperature and compression force played an important role in determining the physical behaviors (hardness, roughness and density) of flakes of the ZrO2nanoparticles. When ZrO2nanoparticles synthesized at 500 °C were pressed into flakes under 6 MPa and sintered at 1400 °C, the resulting flakes exhibited an optimal combination of hardness (534.58 gf·mm-2), roughness (0.07 μm) and density (4.41 g·cm-3). As the Vickers hardness value of human bones is of 315~535 gf·mm-2and the density of adult femuris about 1.3~1.7 g·cm-3, the experimental results showed that the ZrO2flakes were comparable to human bones with a higher density. As a result, the synthesized ZrO2NPs may be useful for biomedical applications, especially for bone repair and replacement in future.
authors.affiliation: Laboratory for Micro-sized Functional Materials &College of Elementary Education, Capital Normal University, Beijing, 100048, PR China.|Department of Chemistry, Capital Normal University, Beijing, 100048, PR China.
authors.forename: Jigang
authors.initials: J
authors.lastname: Wang
authors.affiliation: Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China.
authors.forename: Wenyan
authors.initials: W
authors.lastname: Yin
authors.affiliation: Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: He
authors.affiliation: Laboratory for Micro-sized Functional Materials &College of Elementary Education, Capital Normal University, Beijing, 100048, PR China.|Department of Chemistry, Capital Normal University, Beijing, 100048, PR China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Laboratory for Micro-sized Functional Materials &College of Elementary Education, Capital Normal University, Beijing, 100048, PR China.
authors.forename: Ming
authors.initials: M
authors.lastname: Guo
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA.
authors.forename: Shaowei
authors.initials: S
authors.lastname: Chen
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D006244:Hardness; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D006868:Hydrolysis; D008422:Materials Testing; D018625:Microscopy, Atomic Force; D053758:Nanoparticles / Q000737:chemistry; D013499:Surface Properties; D014961:X-Ray Diffraction; D015040:Zirconium / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D015040:Zirconium; C028541:zirconium oxide