title: Spatial genome organization and cognition.
abstract: Nonrandom chromosomal conformations, including promoter-enhancer loopings that bypass kilobases or megabases of linear genome, provide a crucial layer of transcriptional regulation and move vast amounts of non-coding sequence into the physical proximity of genes that are important for neurodevelopment, cognition and behaviour. Activity-regulated changes in the neuronal '3D genome' could govern transcriptional mechanisms associated with learning and plasticity, and loop-bound intergenic and intronic non-coding sequences have been implicated in psychiatric and adult-onset neurodegenerative disease. Recent studies have begun to clarify the roles of spatial genome organization in normal and abnormal cognition.
authors.affiliation: Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, 10029 New York, USA.
authors.forename: Prashanth
authors.initials: P
authors.lastname: Rajarajan
authors.affiliation: Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain.|Universitat Pompeu Fabra (UPF), Plaça de la Mercè 10, Barcelona 08002, Spain.
authors.forename: Sergio Espeso
authors.initials: SE
authors.lastname: Gil
authors.affiliation: Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, 10029 New York, USA.
authors.forename: Kristen J
authors.initials: KJ
authors.lastname: Brennand
authors.affiliation: Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, 10029 New York, USA.
authors.forename: Schahram
authors.initials: S
authors.lastname: Akbarian
mesh_terms: D000818:Animals; D003071:Cognition / Q000502:physiology*; D019175:DNA Methylation / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D016678:Genome / Q000502:physiology*; D006801:Humans; D065886:Neurodevelopmental Disorders / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D009474:Neurons / Q000473:pathology / Q000502:physiology; D022661:RNA, Untranslated / Q000235:genetics / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D022661:RNA, Untranslated