title: Relationship between homeostasis model assessment of insulin resistance and beta cell function and serum 25-hydroxyvitamin D in non-diabetic Korean adults.
abstract: The purpose of this study is to look at these relationships in non-diabetic Korean adults. This study was based on data from the KNHANES V-1, which is representative of the population of Korea. A total of 5,492 participants (≥20 years in age) without type 1 or type 2 diabetes, assessed for serum 25-hydroxyvitamin D [25(OH)D], fasting blood glucose and insulin, as well as anthropometric variables, were included in the analyses. The key study results were as follows: First, vitamin D status [vitamin D deficient, 25(OH)D <25 nM; vitamin D insufficient, 25(OH)D ≥25, <50 nM; vitamin D sufficient, 25(OH)D ≥50 nM] was inversely associated with homeostasis model assessment of insulin resistance (HOMA-IR) and beta cell function (HOMA-B) in model 2 (adjusted for age and gender) and 3 (further adjusted for smoking, alcohol drinking, regular exercise, systolic and diastolic blood pressure, waist circumference, and body mass index). Second, in model 4, when further adjusted for total cholesterol, triglycerides, and HDL-C, vitamin D status was inversely associated with HOMA-B. However, association of vitamin D status and HOMA-IR was no longer significant. In conclusion, vitamin D was inversely associated with beta cell function in non-diabetic Korean adults but was not associated with insulin resistance.
authors.affiliation: Department of Biomedical Laboratory Science, Hanlyo University, 94-13 Hallyeodae-gil, Gwangyang-eup, Gwangyang-si, Jellanam-do 57764, Korea.
authors.forename: Hyun
authors.initials: H
authors.lastname: Yoon
authors.affiliation: KS Hospital of Physiotherapy, Gwangju, 220, Wangbeodeul-ro, Gwangsan-gu, Gwangju 62248, Korea.
authors.forename: Dae Jung
authors.initials: DJ
authors.lastname: Jeon
authors.affiliation: Department of Biomedical Laboratory Science, Namseoul University, 91 Daehak-ro, Seonghwan-eup, Seobuk-gu, Cheonan-si, Chungcheongnam-do 31020, Korea.
authors.forename: Chang Eun
authors.initials: CE
authors.lastname: Park
authors.affiliation: Department of Nursing, Honam University, 417 Eodeung-daero, Gwangsan-gu, Gwangju 62399, Korea.
authors.forename: Hye Sook
authors.initials: HS
authors.lastname: You
authors.affiliation: Department of Dental Hygiene, Honam University, 417 Eodeung-daero, Gwangsan-gu, Gwangju 62399, Korea.
authors.forename: Ae Eun
authors.initials: AE
authors.lastname: Moon
keywords: HOMA-B; HOMA-IR; non-diabetic adult; vitamin D