title: Drug-induced Pneumonitis Following the Administration of TAS-102.
abstract: A 59-year-old woman, diagnosed with advanced rectal cancer, presented with a low-grade fever and dyspnea on exertion after the 2nd cycle of TAS-102. TAS-102 has promising efficacy in patients with metastatic colorectal cancer. A CT scan revealed mosaic patterns with bilateral ground-glass opacities. The drug lymphocyte stimulation test for TAS-102 was strongly positive and serum β-D glucan level was elevated. The clinical course was compatible with TAS-102-induced pneumonitis combined with pneumocystis pneumonia (PCP). We herein report a rare case of drug-induced pneumonitis in a patient receiving TAS-102 in combination with PCP.
authors.affiliation: Department of Medical Oncology, Izumi Municipal Hospital, Japan.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: Takayo
authors.initials: T
authors.lastname: Ota
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tsukuda
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Suzumura
authors.forename: Masahiro
authors.initials: M
authors.lastname: Fukuoka
mesh_terms: D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011020:Pneumonia, Pneumocystis / Q000139:chemically induced / Q000000981:diagnostic imaging; D011759:Pyrrolidines; D012004:Rectal Neoplasms / Q000188:drug therapy; D013941:Thymine; D014057:Tomography, X-Ray Computed; D014271:Trifluridine / Q000009:adverse effects*; D014498:Uracil / Q000009:adverse effects / Q000031:analogs & derivatives*; D047071:beta-Glucans / Q000097:blood
chemical_list: D004338:Drug Combinations; D011759:Pyrrolidines; D047071:beta-Glucans; C000613803:trifluridine tipiracil drug combination; D014498:Uracil; D013941:Thymine; D014271:Trifluridine