title: Direct Oral Anticoagulants and Women.
abstract: Direct oral anticoagulants (DOACs) provide an effective, safe, and convenient therapeutic alternative to warfarin and other vitamin K antagonists (VKAs), and are now established for a wide range of indications. The use of DOACs in women merits special consideration due to two main situations: first, in relation to fertility, pregnancy, and lactation in women of reproductive age; second, because of their bleeding risk, leading to abnormal uterine and/or other genital tract bleeding. This review focuses on these two clinical situations, including approaches to management in the context of available information.
authors.affiliation: Haemostasis Research Unit, Department of Haematology, University College London, London, United Kingdom.
authors.forename: Hannah
authors.initials: H
authors.lastname: Cohen
authors.affiliation: Department of Haematology, Imperial College Healthcare NHS Trust, London, United Kingdom.
authors.forename: Deepa R J
authors.initials: DR
authors.lastname: Arachchillage
authors.affiliation: Center for Vascular Medicine and Department of Medicine III, University Hospital "Carl Gustav Carus," Technische Universität Dresden, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Beyer-Westendorf
authors.affiliation: Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Holland.
authors.forename: Saskia
authors.initials: S
authors.lastname: Middeldorp
authors.affiliation: Katharine Dormandy Haemophilia Center and Thrombosis Unit, The Royal Free Hospital NHS Foundation Trust, London, United Kingdom.
authors.forename: Rezan A
authors.initials: RA
authors.lastname: Kadir
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000627:therapeutic use*; D005260:Female; D005298:Fertility / Q000187:drug effects; D006801:Humans; D007774:Lactation / Q000187:drug effects; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D014592:Uterine Hemorrhage / Q000188:drug therapy*; D014812:Vitamin K / Q000037:antagonists & inhibitors*
chemical_list: D000925:Anticoagulants; D014812:Vitamin K