title: Neuroimaging findings of Zika virus infection: a review article.
abstract: Zika virus (ZIKV) is an arbovirus from the Flaviviridae family. It is usually transmitted by mosquito bite. There have been no reports of severe symptoms caused by ZIKV infection up until the last few years. In October 2013 an outbreak was reported in French Polynesia with severe neurological complications in some affected cases. In November 2015, the Ministry of Health of Brazil attributed the increased number of neonatal microcephaly cases in northeastern Brazil to congenital ZIKV infection. The rapid spread of the virus convinced the World Health Organization to announce ZIKV infection as a "Public Health Emergency of International Concern" in February 2016. The main neuroimaging findings in congenital ZIKV infection include microcephaly which is the hallmark of the disease, other malformations of cortical development (e.g., lissencephaly, heterotopia, etc.), parenchymal calcifications, unilateral or bilateral ventriculomegaly, enlarged extra-axial CSF spaces, dysgenesis of the corpus callosum, agenesis of the cavum septum pellucidum, cerebellar and brainstem hypoplasia, and ocular abnormalities. ZIKV infection may also cause Guillain-Barré syndrome and acute disseminated encephalomyelitis in adults. Familiarity with neuroimaging findings of congenital and acquired ZIKV infection is crucial to suspect this disease in residents of endemic regions and travelers to these areas.
authors.affiliation: Department of Radiology, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. zare@sbmu.ac.ir.
authors.forename: Mohammad
authors.identifier: http://orcid.org/0000-0001-5793-5323
authors.initials: M
authors.lastname: Zare Mehrjardi
authors.affiliation: Department of Radiology, Mahdieh Women's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Keshavarz
authors.affiliation: Section of Pediatric Neuroradiology, Division of Pediatric Radiology, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Andrea
authors.initials: A
authors.lastname: Poretti
authors.affiliation: Instituto de Medicina Integral Professor Fernando Figueira, Recife, Brazil.
authors.forename: Adriano N
authors.initials: AN
authors.lastname: Hazin
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000382:microbiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D059906:Neuroimaging / Q000379:methods*; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D000071243:Zika Virus Infection / Q000000981:diagnostic imaging*
keywords: Computed tomography (CT); Magnetic resonance imaging (MRI); Neuroimaging; Ultrasound; Zika virus (ZIKV)