title: Therapeutic strategy for efficient reduction of serum uric acid levels with allopurinol versus benzbromarone in hyperuricemic patients with essential hypertension - A randomized crossover study (terao study).
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. Electronic address: kojimas@kumamoto-u.ac.jp.
authors.forename: Sunao
authors.initials: S
authors.lastname: Kojima
authors.affiliation: Department of Internal Medicine, Terao Hospital, Kumamoto, Japan.
authors.forename: Shinobu
authors.initials: S
authors.lastname: Kojima
authors.affiliation: Department of Internal Medicine, Terao Hospital, Kumamoto, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Hifumi
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Soejima
authors.affiliation: National Cerebral and Cardiovascular Center, Suita, Japan.
authors.forename: Hisao
authors.initials: H
authors.lastname: Ogawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000493:Allopurinol / Q000008:administration & dosage / Q000009:adverse effects; D001553:Benzbromarone / Q000008:administration & dosage / Q000009:adverse effects; D004334:Drug Administration Schedule; D016903:Drug Monitoring / Q000379:methods; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000009:adverse effects; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D033461:Hyperuricemia / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D007677:Kidney Function Tests / Q000379:methods; D008297:Male; D008875:Middle Aged; D027361:Organic Anion Transporters / Q000037:antagonists & inhibitors; D013318:Stroke Volume; D016896:Treatment Outcome; D014527:Uric Acid / Q000097:blood*; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors
chemical_list: D004791:Enzyme Inhibitors; D027361:Organic Anion Transporters; C103862:urate transporter; D014527:Uric Acid; D001553:Benzbromarone; D000493:Allopurinol; D014969:Xanthine Oxidase
keywords: Hyperuricemia; UACR; Uric acid; Xanthine oxidase inhibitor