title: Role of Transcranial Doppler in the Evaluation of Vasculopathy in Tuberculous Meningitis.
abstract: BACKGROUND
  Vascular complications are important causes of cerebral infarction in tuberculous meningitis (TBM).Transcranial Doppler ultrasonography (TCD) is a non-invasive tool that can provide real-time information about cerebral hemodynamics. However, the literature on the role of TCD in the diagnosis or monitoring of vasculopathy associated with TBM is scarce. We explored the role of TCD in the diagnosis and monitoring of TBM-related vasculopathy of the major intracranial arteries.
  
  
  METHODS
  Consecutive patients with TBM admitted to our tertiary center between 2011 and 2015 were included. All patients underwent TCD evaluation within 2 weeks of hospitalisation and it was repeated 2 weeks later. Mean flow velocity (Vmean) and pulsatility index (PI) were recorded. Flow velocities obtained from the submandibular internal carotid artery were also measured to calculate the Lindegaard ratio. A correlation was made between the patients who demonstrated vasculopathy on TCD, and patients with confirmed focal narrowing on computed tomography angiography (CTA) or magnetic resonance angiography (MRA). The modified Rankin scale (mRS) was used to assess the clinical outcome at three and six months.
  
  
  RESULTS
  A total of 36 patients were recruited. Focally elevated flow velocities in the middle cerebral artery (MCA) were observed in 11 (30.6%) patients, bilaterally in 6 of them. The Lindegaard ratio was elevated (>3) in 10 (90.9%) of them, which occurred as early as the fourth day of hospitalization and persisted as long as four months. Eighty percent of patients with TBM vasculopathy by TCD criteria, also had narrowing on CTA or MRA. Ten patients (27.8%) achieved good outcome (mRS 0-2) at 3 months, which increased to 13 (36.1%) at 6 months.
  
  
  CONCLUSIONS
  A considerable proportion of patients with TBM develops intracranial vasculopathy, which can be reliably diagnosed and monitored using TCD.
authors.affiliation: Division of Neurology, Department of Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
authors.forename: Mei-Ling Sharon
authors.initials: MS
authors.lastname: Tai
authors.affiliation: Division of Neurology, National University Health System, Singapore, Singapore.
authors.forename: Vijay K
authors.initials: VK
authors.lastname: Sharma
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D001921:Brain / Q000502:physiology; D002544:Cerebral Infarction / Q000175:diagnosis*; D000072226:Computed Tomography Angiography; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007902:Length of Stay; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000502:physiology; D062606:Tertiary Care Centers; D014390:Tuberculosis, Meningeal / Q000175:diagnosis* / Q000000981:diagnostic imaging; D017585:Ultrasonography, Doppler, Transcranial; D055815:Young Adult