title: Spontaneous confabulations in amnestic-mild cognitive impairment due to Alzheimer's disease: a new (yet old) atypical variant?
abstract: Confabulation may be present in Alzheimer's disease (AD), but usually it is not a primary feature of either its typical or atypical variants. In this report, we describe the case of an AD patient who showed an unusual and enduring neuropsychiatric phenotype characterized by early and prominent spontaneous confabulation. Surprisingly, such atypical AD presentation bears a striking resemblance to presbyophrenia, a subtype of dementia which was described at the beginning of the twentieth century and then sank into oblivion. In discussion, we speculate on the "return" of presbyophrenia as an unrecognized neuropsychiatric variant of AD and its possible neuroanatomical substrates.
authors.affiliation: a Geriatric Unit, Fondazione IRCCS Ca' Granda , Ospedale Maggiore Policlinico , Milan , Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Abbate
authors.affiliation: b Alzheimer's Assessment Unit , Fondazione IRCCS Don Carlo Gnocchi, S. Maria Nascente , Milan , Italy.
authors.forename: Pietro Davide
authors.initials: PD
authors.lastname: Trimarchi
authors.affiliation: c Neurologic Unit, Fondazione IRCCS Ca' Granda , Ospedale Maggiore Policlinico , Milan , Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Rotondo
authors.affiliation: a Geriatric Unit, Fondazione IRCCS Ca' Granda , Ospedale Maggiore Policlinico , Milan , Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Inglese
authors.affiliation: d Cardiovascular Diseases Unit, Fondazione IRCCS Ca' Granda , Ospedale Maggiore Policlinico , Milan , Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Nicolini
authors.affiliation: a Geriatric Unit, Fondazione IRCCS Ca' Granda , Ospedale Maggiore Policlinico , Milan , Italy.
authors.forename: Paolo Dionigi
authors.initials: PD
authors.lastname: Rossi
authors.affiliation: a Geriatric Unit, Fondazione IRCCS Ca' Granda , Ospedale Maggiore Policlinico , Milan , Italy.|e Department of Medical Sciences and Community Health , University of Milan , Milan , Italy.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Arosio
authors.affiliation: a Geriatric Unit, Fondazione IRCCS Ca' Granda , Ospedale Maggiore Policlinico , Milan , Italy.|e Department of Medical Sciences and Community Health , University of Milan , Milan , Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Mari
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology*; D000368:Aged; D000544:Alzheimer Disease / Q000150:complications* / Q000523:psychology*; D017028:Caregivers / Q000523:psychology; D060825:Cognitive Dysfunction / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008569:Memory Disorders / Q000209:etiology
keywords: (Spontaneous) confabulations; Alzheimer’s disease (AD); Mild Cognitive Impairment (MCI); atypical variant AD; presbyophrenia