title: Short-term Effects of Risperidone Monotherapy on Spontaneous Brain Activity in First-episode Treatment-naïve Schizophrenia Patients: A Longitudinal fMRI Study.
abstract: It is unclear whether abnormal spontaneous neural activation patterns found in chronic schizophrenia patients (CSP) are part of the pathogenesis of disease, consequences of chronic illness, or effects of antipsychotic treatment. We performed a longitudinal resting-state functional magnetic resonance imaging (fMRI) study in 42 treatment-naïve first-episode schizophrenia patients (FESP) at baseline and then after 8-weeks of risperidone monotherapy, and compared the findings to 38 healthy volunteers. Spontaneous brain activity was quantified using the fractional amplitude of low-frequency fluctuations (fALFF) and regional homogeneity (ReHo) and compared between patients and controls. Pretreatment, patients exhibited higher fALFF in left caudate compared with controls. After treatment, patients had elevated fALFF in bilateral putamen and right caudate, and increased ReHo in right caudate and left putamen. Greater increase of fALFF in the left putamen correlated with less improvement in positive symptoms. Thus, abnormalities of spontaneous neural activity in chronic schizophrenia is at least partly due to a medication effect. The observed post-treatment increase in striatal intrinsic activity may reflect counter-therapeutic functional adaptation to dopamine D2 receptor occupancy required for medication effects on psychosis.
authors.affiliation: Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.|Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute and Departments of Psychiatry and Radiology, Columbia University, New York, NY, USA.|Mental Health Institute of the Second Xiangya Hospital, Central South University, Chinese National Clinical Research Center on Mental Disorders (xiangya), Chinese National Technology Institute on Mental Disorders, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, Hunan, China.
authors.forename: Mao-Lin
authors.initials: ML
authors.lastname: Hu
authors.affiliation: Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.|Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute and Departments of Psychiatry and Radiology, Columbia University, New York, NY, USA.|Mental Health Institute of the Second Xiangya Hospital, Central South University, Chinese National Clinical Research Center on Mental Disorders (xiangya), Chinese National Technology Institute on Mental Disorders, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, Hunan, China.
authors.forename: Xiao-Fen
authors.initials: XF
authors.lastname: Zong
authors.affiliation: Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
authors.forename: Jun-Jie
authors.initials: JJ
authors.lastname: Zheng
authors.affiliation: Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute and Departments of Psychiatry, Columbia University, New York, NY, USA.
authors.forename: Spiro P
authors.initials: SP
authors.lastname: Pantazatos
authors.affiliation: Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute and Departments of Psychiatry and Radiology, Columbia University, New York, NY, USA.
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Miller
authors.affiliation: Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Zong-Chang
authors.initials: ZC
authors.lastname: Li
authors.affiliation: Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.|Department of Psychiatry and Biobehavioral Sciences, UCLA Semel Institute for Neuroscience, David Geffen School of Medicine, Los Angeles, CA, USA.
authors.forename: Yan-Hui
authors.initials: YH
authors.lastname: Liao
authors.affiliation: Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Radiology, Henan Mental Hospital, the Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China.
authors.forename: De-En
authors.initials: DE
authors.lastname: Sang
authors.affiliation: Department of Radiology, Henan Mental Hospital, the Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China.
authors.forename: Hong-Zeng
authors.initials: HZ
authors.lastname: Zhao
authors.affiliation: Department of Psychiatry, Henan Mental Hospital, the Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China.|Henan Key Lab of Biological Psychiatry, Henan Mental Hospital, Xinxiang Medical University, Xinxiang, Henan, China.
authors.forename: Lu-Xian
authors.initials: LX
authors.lastname: Lv
authors.affiliation: Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.|Department of Psychiatry and Biobehavioral Sciences, UCLA Semel Institute for Neuroscience, David Geffen School of Medicine, Los Angeles, CA, USA.
authors.forename: Jin-Song
authors.initials: JS
authors.lastname: Tang
authors.affiliation: Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute and Departments of Psychiatry and Radiology, Columbia University, New York, NY, USA.
authors.forename: J John
authors.initials: JJ
authors.lastname: Mann
authors.affiliation: Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.|Mental Health Institute of the Second Xiangya Hospital, Central South University, Chinese National Clinical Research Center on Mental Disorders (xiangya), Chinese National Technology Institute on Mental Disorders, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, Hunan, China.
authors.forename: Xiao-Gang
authors.initials: XG
authors.lastname: Chen
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D018967:Risperidone / Q000494:pharmacology / Q000627:therapeutic use*; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D018967:Risperidone