title: Antifungal activities of diphenyl diselenide and ebselen against echinocandin-susceptible and -resistant strains of Candida parapsilosis.
abstract: We evaluated the in vitro antifungal activity of diphenyl diselenide and ebselen against echinocandin-susceptible and -resistant strains of Candida parapsilosis using the broth microdilution method. Diphenyl diselenide (MIC range =1-8 µg/mL) and ebselen (MIC range =0.25-4 µg/mL) showed in vitro activity against echinocandin-susceptible isolates. However, ebselen also showed the highest antifungal activity against echinocandin-resistant strains (MIC range =0.06-4 µg/mL). This study demonstrated that the antifungal potential of diphenyl diselenide and ebselen deserves further investigation using in vivo experimental protocols.
authors.affiliation: Postgraduate Program in Pharmaceutical Sciences, Health Sciences Centre, Federal University of Santa Maria, RS, Brazil.
authors.forename: Francieli
authors.initials: F
authors.lastname: Chassot
authors.affiliation: Postgraduate Program in Pharmaceutical Sciences, Health Sciences Centre, Federal University of Santa Maria, RS, Brazil.
authors.forename: Tarcieli
authors.initials: T
authors.lastname: Pozzebon Venturini
authors.affiliation: Postgraduate Program in Pharmaceutical Sciences, Health Sciences Centre, Federal University of Santa Maria, RS, Brazil.
authors.forename: Fernanda
authors.initials: F
authors.lastname: Baldissera Piasentin
authors.affiliation: Postgraduate Program in Biosciences and Pathophysiology, Department of Clinical Analysis and Biomedicine, State University of Maringa, PR, Brazil.
authors.forename: Janio
authors.initials: J
authors.lastname: Morais Santurio
authors.affiliation: Postgraduate Program in Pharmacology, Health Sciences Centre, Federal University of Santa Maria, RS, Brazil.
authors.forename: Terezinha Inez
authors.initials: TI
authors.lastname: Estivalet Svidzinski
authors.affiliation: Postgraduate Program in Pharmaceutical Sciences, Health Sciences Centre, Federal University of Santa Maria, RS, Brazil.
authors.forename: Sydney
authors.initials: S
authors.lastname: Hartz Alves
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology*; D001555:Benzene Derivatives / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000494:pharmacology*; D054833:Isoindoles; D008826:Microbial Sensitivity Tests; D016566:Organoselenium Compounds / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D001393:Azoles; D001555:Benzene Derivatives; D054714:Echinocandins; D054833:Isoindoles; D016566:Organoselenium Compounds; C061132:diphenyldiselenide; C042986:ebselen
keywords: Candida parapsilosis; Diphenyl diselenide; antifungal agents; ebselen; echinocandin