title: Effects of ZNF139 on gastric cancer cells and mice with gastric tumors.
abstract: Gastric cancer (GC) is the fourth most common type of cancer, worldwide. The major molecular factors associated with the pathogenesis of GC remain unclear. Previous studies found that zinc finger proteins are highly abundant in human eukaryotes and tissues, and play an important role in maintaining normal cellular functions and have an association with tumor initiation. In the current study, interference technology was used to silence the ZNF139 protein, a zinc finger protein that was previously found to be closely associated with GC. The results showed that cell viability and proliferation were inhibited in theZnf139-knockdown of GC cells. Additional study found that the expression levels of B cell lymphoma-2 (Bcl-2) and survivin messenger RNAs and proteins were downregulated inZnf139-silenced cells, indicating that cells expressionZnf139are able to induce the growth of tumor cells by mediating the apoptosis pathway. Furtherin vivoexperiments showed thatZnf139knockdown downregulated the expression levels of Bcl-2 and survivin in mice. Overall, thein vitroandin vivofindings of the present study indicate that ZNF139 may be actively involved in the progression of GC.
authors.affiliation: Department of General Surgery, The First Affiliated Hospital, Xingtai Medical College, Xingtai, Hebei 054001, P.R. China.
authors.forename: Hong-Feng
authors.initials: HF
authors.lastname: Nie
authors.affiliation: Department of General Surgery, The Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of General Surgery, Hebei United University Affiliated Hospital, Tangshan, Hebei 063000, P.R. China.
authors.forename: Zhen-Xing
authors.initials: ZX
authors.lastname: Li
authors.affiliation: Department of General Surgery, The First Affiliated Hospital, Xingtai Medical College, Xingtai, Hebei 054001, P.R. China.
authors.forename: Ji-Xing
authors.initials: JX
authors.lastname: Mu
authors.affiliation: Department of General Surgery, The First Affiliated Hospital, Xingtai Medical College, Xingtai, Hebei 054001, P.R. China.
authors.forename: Jin-Sheng
authors.initials: JS
authors.lastname: Wang
keywords: B cell lymphoma-2; apoptosis; gastric cancer; survivin; zinc finger protein 139