title: Hypoglycemic and hypolipidemic effects of Lactobacillus fermentum, fruit extracts of Syzygium cumini and Momordica charantia on diabetes induced mice.
abstract: A lot of treatment strategies available for diabetes but its complications are still a medical problem around the globe. It demands to find out some alternative therapeutic measures. In order to investigate the anti-diabetic potential of probiotics and natural extracts, this study was designed. Accordingly, a local source of yogurt probiotic strain Lactobacillus fermentum was isolated and characterized that showed its probiotic properties. Besides this, natural extracts of plants fruits like java plum (Syzygium cumini) and bitter gourd (M. charantia) were made. Lactobacillus fermentum and the extracts were administered individually as well as in combination to diabetes induced mice. Different parameters like body weight, blood glucose level and lipid profile including total cholesterol, HDL & LDL were analyzed before and after treatment. The results showed that Lactobacillus fermentum and natural extracts have hypoglycemic as well hypolipidemic activity against diabetic mice. This study can further investigated to screen potential compounds from these extracts to control the glucose and the lipid levels in diabetic patients.
authors.affiliation: Department of Microbiology and Molecular Genetics: University of the Punjab, New campus Lahore, Pakistan.
authors.forename: Sehar
authors.initials: S
authors.lastname: Yousaf
authors.affiliation: Department of Microbiology and Molecular Genetics, University of the Punjab, New campus Lahore, Pakistan.
authors.forename: Abid
authors.initials: A
authors.lastname: Hussain
authors.affiliation: Department of Microbiology and Molecular Genetics: University of the Punjab, New campus Lahore, Pakistan.
authors.forename: Shafiqur
authors.initials: S
authors.lastname: Rehman
authors.affiliation: Institute of Biochemistry and Biotechnology, University of the Punjab, Quaid-e-Azam Campus, Lahore, Pakistan.
authors.forename: Muhammad Shahbaz
authors.initials: MS
authors.lastname: Aslam
authors.affiliation: Department of Microbiology and Molecular Genetics, University of the Punjab, New campus Lahore, Pakistan.
authors.forename: Zaigham
authors.initials: Z
authors.lastname: Abbas
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D005638:Fruit; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D052197:Limosilactobacillus fermentum / Q000502:physiology*; D008055:Lipids / Q000097:blood*; D051379:Mice; D029777:Momordica charantia / Q000737:chemistry; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D019936:Probiotics; D013311:Streptozocin; D027842:Syzygium / Q000737:chemistry
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D008055:Lipids; D010936:Plant Extracts; D013311:Streptozocin