title: A case of Primary Bone Anaplastic Large Cell Lymphoma.
abstract: BACKGROUND Anaplastic large cell lymphoma (ALCL) is a relatively rare subtype of non-Hodgkin's lymphoma (NHL). Like other types of NHL, ALCL primarily involves the nodal area, and sometimes it can involve several extra-nodal sites such as skin, soft tissue, and lungs. However, extensive bone involvement in cases of ALCL is very rare whether it is primary or secondary. Without nodular involvement, ALCL can be misdiagnosed as bone tumor or metastatic carcinoma such as lung, breast, or prostate cancer, which frequently spread to bone. CASE REPORT A 52-year-old woman with generalized pain and 2 months of fever of unknown origin presented to our institution. After extensive evaluation, only multiple osteolytic bone lesions with periosteal soft tissue reaction were identified. Repeated core needle biopsy revealed only inflammatory cells with histiocytic reactions. After pathologic and chromosomal analysis of sufficient tissue, which was acquired from incisional biopsy, primary bone ALCL was confirmed. CONCLUSIONS Clinicians should keep in mind that ALCL can present with extensive bone involvement without nodal involvement.
authors.affiliation: Division of Medical Oncology, Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Kore, Seoul, South Korea.
authors.forename: Kyung Hyun
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Division of Medical Oncology, Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Kore, Seoul, South Korea.
authors.forename: Yun Hwa
authors.initials: YH
authors.lastname: Jung
authors.affiliation: Division of Medical Oncology, Department of Internal Medicine, Cheju Halla General Hospital, Jeju, South Korea.
authors.forename: Chi Wha
authors.initials: CW
authors.lastname: Han
authors.affiliation: Division of Medical Oncology, Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea,Seoul, South Korea.
authors.forename: In Sook
authors.initials: IS
authors.lastname: Woo
authors.affiliation: Division of Medical Oncology, Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea,Seoul, South Korea.
authors.forename: Jong Ho
authors.initials: JH
authors.lastname: Son
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology*; D003520:Cyclophosphamide; D004317:Doxorubicin; D005260:Female; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology*; D008875:Middle Aged; D011241:Prednisone; D014057:Tomography, X-Ray Computed; D014750:Vincristine; D051598:Whole Body Imaging
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone