title: Iodine-promoted cyclization of N-propynyl amides and N-allyl amides via sulfonylation and sulfenylation.
abstract: An iodine-promoted regioselective cyclization of N-propynyl/allyl amides with sulfonyl hydrazides has been developed for the synthesis of 5-methyl-arylsulfonyloxazoles and 5-methyl-arylthiooxazolines via sulfonylation and sulfenylation reactions. The notable features of this reaction are the formation of new C-S and C-O bonds, the broad functional group tolerance, and its applicability to alkyl sulfonyl hydrazides as well as internal alkynes.
authors.affiliation: Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, No. 100, Shiquan 1st Rd, Sanmin District, Kaohsiung City, 807, Taiwan. jjwang@kmu.edu.tw.
authors.forename: Gopal Chandru
authors.initials: GC
authors.lastname: Senadi
authors.affiliation: Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, No. 100, Shiquan 1st Rd, Sanmin District, Kaohsiung City, 807, Taiwan. jjwang@kmu.edu.tw.
authors.forename: Bing-Chun
authors.initials: BC
authors.lastname: Guo
authors.affiliation: Department of Biotechnology, Kaohsiung Medical University, No. 100, Shiquan 1st Rd, Sanmin District, Kaohsiung City, 807, Taiwan.
authors.forename: Wan-Ping
authors.initials: WP
authors.lastname: Hu
authors.affiliation: Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, No. 100, Shiquan 1st Rd, Sanmin District, Kaohsiung City, 807, Taiwan. jjwang@kmu.edu.tw.
authors.forename: Jeh-Jeng
authors.initials: JJ
authors.lastname: Wang