title: Components of metabolic syndrome in the first trimester of pregnancy as predictors of adverse perinatal outcome.
abstract: It is the prospective observational study aimed at early prediction of pregnancy complications in women with symptoms of MS.
  
  
  
  124 Caucasian women in singleton pregnancies 11th to the 13th wks 6 days of gestation with MS criteria compared to 30 healthy controls. Perinatal maternal and fetal results were analyzed.
  
  
  
  Increased in the MS group were: age (32.9 y vs. 28.6 y; p = 0,00), weight 11 to 13 + 6 weeks of gestation (79.0 kg vs. 59.7 kg; p = 0.00), BMI (29 kg/m² vs. 21.6 kg/m²; p = 0.00), waist-hip ratio (WHR) (0.9 vs. 0.8; p = 0.00). Maternal serum parameters were higher in the MS group: LDL-cholesterol (124.1 vs. 109.6 mg/dL; p = 0.02), t-PA (2556.8 vs. 1949.5 pg/mL; p < 0.00), GGTP (16.8 vs. 13.3 IU/L; p = 0.02) and lower values for: adiponectin (6.4 vs. 7.5 μg/mL; p = 0.01), SHBG (273.4 vs. 338.4 nmol/L; p = 0.001). MS group neonates higher body weight (3594.4 vs. 3312.2 g; p = 0.01), significantly frequent macrosomic neo-nates (> 4000 g) (20.9% vs. 6.6%; p = 0.042), GDM (12% vs. 0; p = 0.019).
  
  
  
  Higher E-selectin serum concentration, GGTP and lower SHBG in first trimester are additionally to fasting maternal glucose, higher BMI and maternal age predictive for GDM. Higher E-selectin, fasting glucose, increased BMI and lower adiponectin serum concentration in first trimester are significant predictors of fetal macrosomia. Maternal BMI > 24.5 kg/m² is the best predictor of increased risk of fetal macrosomia and gestational diabetes mellitus.
authors.affiliation: Clinical Unit of Obstetrics, Women's Disease and Gynecological Oncology, United District Hospital, Collegium Medicum University of Nicolaus Copernicus in Torun, Poland. mchmigda@wp.pl.
authors.forename: Michał
authors.initials: M
authors.lastname: Migda
authors.forename: Marian S
authors.initials: MS
authors.lastname: Migda
authors.forename: Bartosz
authors.initials: B
authors.lastname: Migda
authors.forename: Patrycja
authors.initials: P
authors.lastname: Krzyżanowska
authors.forename: Ewa
authors.initials: E
authors.lastname: Wender-Ożegowska
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016640:Diabetes, Gestational / Q000097:blood / Q000175:diagnosis; D005260:Female; D006801:Humans; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000175:diagnosis*; D011261:Pregnancy Trimester, First; D011446:Prospective Studies
chemical_list: D015415:Biomarkers
keywords: E-selectin; adiponectin; body mass index (BMI); gestational diabetes mellitus; macrosomy; metabolic syndrome