title: Mdm2-RNA Interactions as a Target for Cancer Therapy: It's Not All About p53.
abstract: In this issue of Cancer Cell, Gu et al. characterize small molecules that inhibit the interaction of Mdm2 with the mRNA that encodes the anti-apoptotic XIAP, simultaneously decreasing expression of both proteins. This represents a novel approach that has relevance in tumor cells independent of p53 status.
authors.affiliation: Department of Oncological Sciences and The Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Bohlman
authors.affiliation: Department of Oncological Sciences and The Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: james.manfredi@mssm.edu.
authors.forename: James J
authors.initials: JJ
authors.lastname: Manfredi
mesh_terms: D017209:Apoptosis; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics; D012313:RNA; D012333:RNA, Messenger / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D016159:Tumor Suppressor Protein p53; D012313:RNA; D051736:Proto-Oncogene Proteins c-mdm2