title: Comparison of postoperative venous thromboembolism incidence in gastrointestinal and gynecologic solid tumors.
abstract: BACKGROUND
  Studies have shown the benefit of 28days of extended postoperative venous thromboembolism (VTE) prophylaxis for patients undergoing major cancer surgery in the abdomen or pelvis. We retrospectively evaluated the VTE incidence at the University of Kansas Hospital between gynecologic (GYN) cancer patients, who receive extended prophylaxis, and gastrointestinal (GI) cancer patients, who do not.
  
  
  METHODS
  Patients were evaluated between January of 2010 and December of 2013, and VTE data for eligible patients were collected for 30 and 90days postoperatively.
  
  
  RESULTS
  The study population composed of 190 GYN and 204 GI patients. Colon and endometrial cancers were the most common diagnoses. For GYN and GI patients respectively, VTE occurred in 4.2% and 5.4% at 30days (p=0.584) and 7.4% and 7.8% at 90days (p=0.514). One VTE-related death occurred in the GI group. GI patients underwent more open surgeries, 77.9% versus 66.3% (p=0.010) and had longer postoperative hospital stay, median of 7 versus 4days (p<0.0001). Out of all cancer patients combined, 40% versus 17.9% had stage IV disease and 10.2% versus 0.9% had open surgery in the VTE and non-VTE groups, respectively.
  
  
  CONCLUSIONS
  There were no significant differences in overall VTE incidence between the two patient groups at 30 and 90days postoperatively. A majority of VTEs occurred in stage IV patients and patients who underwent open surgeries regardless of diagnosis.
authors.affiliation: Department of Pharmacy, The University of Kansas Hospital, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA. Electronic address: tmelancon@kumc.edu.
authors.forename: Tina
authors.initials: T
authors.lastname: Melancon
authors.affiliation: Department of Pharmacy, The University of Kansas Hospital, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA; University of Kansas School of Pharmacy, 2010 Becker Drive, Lawrence, KS 66047, USA.
authors.forename: Cory
authors.initials: C
authors.lastname: Bivona
authors.affiliation: Department of Pharmacy, The University of Kansas Hospital, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.
authors.forename: Susan
authors.initials: S
authors.lastname: Klenke
authors.affiliation: Department of Pharmacy, The University of Kansas Hospital, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA; University of Kansas School of Pharmacy, 2010 Becker Drive, Lawrence, KS 66047, USA.
authors.forename: Michelle
authors.initials: M
authors.lastname: Rockey
authors.affiliation: Department of Pharmacy, The University of Kansas Hospital, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.
authors.forename: Jane
authors.initials: J
authors.lastname: Huh
authors.affiliation: University of Kansas School of Pharmacy, 2010 Becker Drive, Lawrence, KS 66047, USA.
authors.forename: Dave
authors.initials: D
authors.lastname: Henry
authors.affiliation: University of Kansas School of Pharmacy, 2010 Becker Drive, Lawrence, KS 66047, USA.
authors.forename: Dennis
authors.initials: D
authors.lastname: Grauer
authors.affiliation: University of Kansas School of Medicine, 2411 Holmes Street, Kansas City, MO 64108, USA.
authors.forename: Mazin
authors.initials: M
authors.lastname: Al-Kasspooles
authors.affiliation: University of Kansas School of Medicine, 2411 Holmes Street, Kansas City, MO 64108, USA.
authors.forename: Gary
authors.initials: G
authors.lastname: Johnson
authors.affiliation: University of Kansas School of Medicine, 2411 Holmes Street, Kansas City, MO 64108, USA.
authors.forename: Evelyn
authors.initials: E
authors.lastname: Reynolds
authors.affiliation: University of Kansas School of Medicine, 2411 Holmes Street, Kansas City, MO 64108, USA.
authors.forename: Julia
authors.initials: J
authors.lastname: Chapman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000627:therapeutic use; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000150:complications / Q000601:surgery*; D005833:Genital Neoplasms, Female / Q000150:complications / Q000601:surgery*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology* / Q000517:prevention & control; D012307:Risk Factors; D054556:Venous Thromboembolism / Q000209:etiology* / Q000517:prevention & control; D055815:Young Adult
chemical_list: D000925:Anticoagulants
keywords: Cancer; Extended prophylaxis; Postoperative; Risk factors; Venous thromboembolism