title: Catalyst-free synthesis of α1-oxindole-α-hydroxyphosphonates via phospha-aldol reaction of isatins employing N-heterocyclic phosphine (NHP)-thiourea.
abstract: A highly efficient phospha-aldol reaction for the synthesis of α1-oxindole-α-hydroxyphosphonates is developed utilizing N-heterocyclic phosphine (NHP)-thiourea as a phosphonylation reagent under catalyst, additive free conditions. This methodology encompasses a variety of isatin derivatives to provide α1-oxindole- α-hydroxyphosphonates up to 99% yield.
authors.affiliation: Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, 4505 S Maryland Parkway, Las Vegas, Nevada 89154-4003, USA. junyong.kang@unlv.edu.
authors.forename: Nagaraju
authors.initials: N
authors.lastname: Molleti
authors.affiliation: Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, 4505 S Maryland Parkway, Las Vegas, Nevada 89154-4003, USA. junyong.kang@unlv.edu.
authors.forename: Jun
authors.identifier: http://orcid.org/0000-0002-7178-2981
authors.initials: J
authors.lastname: Yong Kang
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D007510:Isatin / Q000138:chemical synthesis / Q000737:chemistry*; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry; D000078183:Oxindoles; D010720:Phosphines / Q000138:chemical synthesis / Q000737:chemistry*; D013890:Thiourea / Q000031:analogs & derivatives* / Q000138:chemical synthesis
chemical_list: D000447:Aldehydes; D007211:Indoles; D063065:Organophosphonates; D000078183:Oxindoles; D010720:Phosphines; C022960:2-oxindole; D007510:Isatin; C116609:3-hydroxybutanal; C044646:phosphine; D013890:Thiourea