title: Postoperative value of serum squamous cell carcinoma antigen as a predictor of recurrence in sinonasal inverted papilloma.
abstract: OBJECTIVE
  Sinonasal inverted papilloma (IP) has several unfavourable characteristics and therefore requires careful monitoring. The goal of this study was to identify whether serum squamous cell carcinoma antigen (SCCa) could predict IP recurrence.
  
  
  METHODS
  A retrospective cohort study.
  
  
  METHODS
  Department of otolaryngology/head and neck surgery, Erasmus Medical Centre, Rotterdam, the Netherlands.
  
  
  METHODS
  One hundred and thirty patients with IP treated at our centre with SCCa measurements available were included.
  
  
  METHODS
  Follow-up of patients with IP since 2005, recurrence was defined as new disease within primary localisation at least 3 months after adequate surgical removal. We analysed the association between IP recurrence and serum SCCa values measured preoperatively, postoperatively and during follow-up.
  
  
  RESULTS
  Preoperative SCCa values or values measured during follow-up were not associated with risk of recurrence. Postoperative SCCa was positively associated with the risk of recurrence (P < 0.001). Postoperative SCCa had a good discriminative ability for the identification of recurrence with an area under the curve of 80.9%.
  
  
  CONCLUSIONS
  Postoperative SCCa is strongly associated with risk of recurrence. This might help the surgeon in the postoperative setting by identifying high-risk patients and planning follow-up strategy tailored to the individual patient.
authors.affiliation: Department of Otolaryngology and Head and Neck Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: F V W J
authors.initials: FVWJ
authors.lastname: van Zijl
authors.affiliation: Department of Otolaryngology and Head and Neck Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: D A
authors.initials: DA
authors.lastname: Monserez
authors.affiliation: Department of endocrinology, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: T I M
authors.initials: TIM
authors.lastname: Korevaar
authors.affiliation: Department of Otolaryngology and Head and Neck Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: O
authors.initials: O
authors.lastname: Bugter
authors.affiliation: Department of Otolaryngology and Head and Neck Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: M H
authors.initials: MH
authors.lastname: Wieringa
authors.affiliation: Department of Otolaryngology and Head and Neck Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: R J
authors.initials: RJ
authors.lastname: Baatenburg de Jong
authors.affiliation: Department of Otolaryngology and Head and Neck Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: J A U
authors.initials: JAU
authors.lastname: Hardillo
mesh_terms: D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D009367:Neoplasm Staging; D009426:Netherlands / Q000453:epidemiology; D009669:Nose Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000601:surgery; D013517:Otorhinolaryngologic Surgical Procedures; D018308:Papilloma, Inverted / Q000097:blood* / Q000175:diagnosis / Q000601:surgery; D010255:Paranasal Sinus Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000601:surgery; D011184:Postoperative Period; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D015843:Serpins / Q000097:blood*; D013997:Time Factors; D055815:Young Adult
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D015843:Serpins; C051072:squamous cell carcinoma-related antigen