title: Population-based estimation of renal function in healthy young Indian adults based on body mass index and sex correlating renal volume, serum creatinine, and cystatin C.
abstract: This population-based prospective study was undertaken in Mahatma Gandhi Medical College to estimate the renal function in young healthy Indian adults. A young healthy heterogeneous Indian cohort comprising 978 individuals, predominantly medical students, was assessed by a detailed questionnaire, and variables such as height, weight, body mass index (BMI), birth weight, and blood pressure were documented. Laboratory investigations included serum creatinine, serum cystatin C, blood sugar, urine protein, and imaging of the kidneys with ultrasound. The mean age of the cohort was 25±6 years, comprising 672 males and 306 females. The estimated glomerular filtration rates (eGFRs) by the Cockcroft-Gault formula for BMI <18.5 kg/m2, 18.5-24.99 kg/m2, 25-29.99 kg/m2, and ≥30 kg/m2were 71.29±10.45 mL/min, 86.38±13.46 mL/min, 98.88±15.29 mL/min, and 109.13±21.57 mL/min, respectively; the eGFRs using cystatin C for the four groups of BMI were 84.53±18.14 mL/min, 84.01±40.11 mL/min, 79.18±13.46 mL/min, and 77.30±10.90 mL/min, respectively. This study attempts to establish a normal range of serum creatinine and cystatin C values for the Indian population and shows that in young healthy Indian adults, eGFR and kidney volume vary by BMI and sex.
authors.affiliation: Department of General Medicine, Mahatma Gandhi Medical College and Research Institute, Puducherry.
authors.forename: Prashanth
authors.initials: P
authors.lastname: Rajagopalan
authors.affiliation: Department of Nephrology, Madras Medical Mission Hospital, Chennai, India.
authors.forename: Georgi
authors.initials: G
authors.lastname: Abraham
authors.affiliation: Department of Nephrology, Madras Medical Mission Hospital, Chennai, India.
authors.forename: Yuvaram Nv
authors.initials: YN
authors.lastname: Reddy
authors.affiliation: Department of General Medicine, Mahatma Gandhi Medical College and Research Institute, Puducherry.
authors.forename: Ravivarman
authors.initials: R
authors.lastname: Lakshmanasami
authors.affiliation: Department of General Medicine, Mahatma Gandhi Medical College and Research Institute, Puducherry.
authors.forename: M L
authors.initials: ML
authors.lastname: Prakash
authors.affiliation: Department of Nephrology, Madras Medical Mission Hospital, Chennai, India.
authors.forename: Yogesh Nv
authors.initials: YN
authors.lastname: Reddy
keywords: birth weight; eGFR; renal volume