title: Diagnostic Approach to Patients with Atypical Squamous Cells of Undetermined Significance Cytologic Findings on Cervix.
abstract: BACKGROUND
  Atypical squamous cells of undetermined significance (ASCUS) is a term that refers to inflammatory, reactive and reparative processes which are atypical and of higher level and insufficient to be classified as cervical intraepithelial lesions (CIN).
  
  
  OBJECTIVE
  Examine of frequency of HPV infection in ASCUS lesions and regression, stagnation and progression during six-month period.
  
  
  METHODS
  Prospective study was conducted over a period of 3 years. In private gynecological ambulance "Dr Mahira Jahic". Analysis of PAP smears and HPV typization have been done in 50 patients and PAP test has been repeated after six months. X² test was used for statistical analysis.
  
  
  RESULTS
  Analysis of 1784 PAP smears showed normal results in 86,6% (N-1530), and abnormal in 13% (N-254). ASCUS in 7,4% (N-133) and ASC-H in 0,5% (N-9), LSIL in 4,4% (N-80), HSIL in 1,3% (N-24), CIN II in 1,2% (N-20), CIN III in 0,2% (N-4). Progression occurred in 18% (9), persistence in 74% (37) and regression in 8%. Patients with ASC-H lesion 0,5% (N-9), PH results showed 22% (N-2) Carcinoma in situ, 33% (N-3) CIN II, 22% (N-2) CIN I and 22% (N-2) chronic cervicitis. Patients with CIN I in 88% (N-7) were positive on HPV of high risk. Patients with persistent ASCUS result were positive in 51% (N-19). The number of CIN I lesions found in women with ASCUS is bigger and statistically significant (p<0,05) in relation to number of CIN I findings found in regular examinations.
  
  
  CONCLUSIONS
  Monitoring women with ASCUS lesion, especially HPV positive to high risk group is the best way of selection of women who should be treated and monitored in order to prevent cervical cancer.
authors.affiliation: Private Gynecology Ordination, Dr Mahira Jahic" Tuzla, Bosnia and Herzegovina; Faculty of Medicine, University of Tuzla, Tuzla, Bosnia and Herzegovina.
authors.forename: Mahira
authors.initials: M
authors.lastname: Jahic
authors.affiliation: Faculty of Medicine, University of Tuzla, Tuzla, Bosnia and Herzegovina; Cardiovascular Clinic, University Clinical Center Tuzla, Bosnia and Herzegovina.
authors.forename: Elmir
authors.initials: E
authors.lastname: Jahic
mesh_terms: D000328:Adult; D065309:Atypical Squamous Cells of the Cervix / Q000473:pathology* / Q000821:virology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D065006:Papanicolaou Test; D030361:Papillomavirus Infections / Q000150:complications* / Q000473:pathology*; D011446:Prospective Studies; D014626:Vaginal Smears
keywords: ASCUS; Cervical cancer prevention; HPV; Pap test