title: Potential Drug Interaction Between an Antiplatelet Agent and a Proton Pump Inhibitor.
abstract: Older adults frequently have multiple medical conditions and consequently receive multiple medications. Cardiovascular (CV) and gastrointestinal disorders are two conditions in seniors that often require both long-term antiplatelet therapy and medications for GI prophylaxis. Clopidogrel and pantoprazole are commonly used for these conditions; however, there are potential adverse consequences secondary to drug interactions. Both of these drugs are metabolized via the cytochrome P450 system, and there is a potential for drug interactions that may result in decreased effectiveness of clopidogrel and an increased risk of adverse CV outcomes. Pharmacists should be informed of these potential drug interactions and take appropriate actions to assure safe and effective patient care.
authors.affiliation: Long Island University (LIU) Pharmacy, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Brooklyn, New York, USA.
authors.forename: Timothy
authors.initials: T
authors.lastname: Nguyen
authors.forename: Roza
authors.initials: R
authors.lastname: Gavrilova
authors.forename: Marina
authors.initials: M
authors.lastname: Blazhko
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000009:adverse effects / Q000627:therapeutic use; D000368:Aged; D000077144:Clopidogrel; D004347:Drug Interactions; D006801:Humans; D008297:Male; D000077402:Pantoprazole; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D054328:Proton Pump Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D013988:Ticlopidine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use; D014652:Vascular Diseases / Q000150:complications / Q000188:drug therapy
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D010975:Platelet Aggregation Inhibitors; D054328:Proton Pump Inhibitors; D000077144:Clopidogrel; D000077402:Pantoprazole; D013988:Ticlopidine