title: Changes in plasma ghrelin and leptin levels in patients with peptic ulcer and gastritis following eradication of Helicobacter pylori infection.
abstract: BACKGROUND
  Helicobacter pylori (H. pylori) infection and eradication therapy have been known to influence gastric ghrelin and leptin secretion, which may lead to weight gain. However, the exact relationship between plasma ghrelin/leptin levels and H. pylori infection has remained controversial. The aim of this study was to investigate plasma ghrelin and leptin levels in H. pylori-positive and -negative patients, to compare the two levels of the hormones before and after H. pylori eradication, and to examine the correlation between body mass index (BMI) and active ghrelin or leptin levels, as well as that between atrophic pattern and active ghrelin or leptin levels.
  
  
  METHODS
  Seventy-two H. pylori-positive patients who underwent upper gastrointestinal endoscopy, 46 diagnosed as having peptic ulcer and 26 as atrophic gastritis, were enrolled. Control samples were obtained from 15 healthy H. pylori-negative volunteers. The extent of atrophic change of the gastric mucosa was assessed endoscopically. Body weight was measured and blood was collected before and 12 weeks after H. pylori eradication therapy. Blood samples were taken between 8 and 10 AM after an overnight fast.
  
  
  RESULTS
  Plasma ghrelin levels were significantly lower in H. pylori-positive patients than in H. pylori-negative patients. In particular, plasma active ghrelin levels were significantly lower in patients with gastritis compared with patients with peptic ulcer. Plasma ghrelin levels decreased after H. pylori eradication in both peptic ulcer and gastritis patients, while plasma leptin levels increased only in peptic ulcer patients. Plasma leptin levels and BMI were positively correlated, and active ghrelin levels and atrophic pattern were weakly negatively correlated in peptic ulcer patients.
  
  
  CONCLUSIONS
  H. pylori infection and eradication therapy may affect circulating ghrelin/leptin levels. This finding suggests a relationship between gastric mucosal injury induced by H. pylori infection and changes in plasma ghrelin and leptin levels.
authors.affiliation: Department of Gastroenterology, Mie Prefectural General Medical Center, Yokkaichi, Japan.
authors.forename: Chika
authors.initials: C
authors.lastname: Kasai
authors.affiliation: Department of Molecular and Laboratory Medicine, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan. kazushi@clin.medic.mie-u.ac.jp.|Department of Gastroenterology and Hepatology, Mie University School of Medicine, Tsu, Japan. kazushi@clin.medic.mie-u.ac.jp.
authors.forename: Kazushi
authors.initials: K
authors.lastname: Sugimoto
authors.affiliation: Department of Gastroenterology, Mie Prefectural General Medical Center, Yokkaichi, Japan.
authors.forename: Isao
authors.initials: I
authors.lastname: Moritani
authors.affiliation: Department of Gastroenterology, Mie Prefectural General Medical Center, Yokkaichi, Japan.
authors.forename: Junichiro
authors.initials: J
authors.lastname: Tanaka
authors.affiliation: Department of Gastroenterology, Mie Prefectural General Medical Center, Yokkaichi, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Oya
authors.affiliation: Department of Gastroenterology, Mie Prefectural General Medical Center, Yokkaichi, Japan.
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Inoue
authors.affiliation: Department of Molecular and Laboratory Medicine, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.|Department of Gastroenterology and Hepatology, Mie University School of Medicine, Tsu, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tameda
authors.affiliation: Department of Gastroenterology, Mie Prefectural General Medical Center, Yokkaichi, Japan.
authors.forename: Katsuya
authors.initials: K
authors.lastname: Shiraki
authors.affiliation: Department of Cardiology and Nephrology, Mie University School of Medicine, Tsu, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Ito
authors.affiliation: Department of Gastroenterology and Hepatology, Mie University School of Medicine, Tsu, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Takei
authors.affiliation: Department of Gastroenterology, Mie Prefectural General Medical Center, Yokkaichi, Japan.
authors.forename: Kojiro
authors.initials: K
authors.lastname: Takase
mesh_terms: D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000897:Anti-Ulcer Agents / Q000008:administration & dosage; D001706:Biopsy; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects; D016022:Case-Control Studies; D017291:Clarithromycin / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D016145:Endoscopy, Digestive System; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D005757:Gastritis, Atrophic / Q000097:blood* / Q000382:microbiology; D054439:Ghrelin / Q000097:blood*; D016481:Helicobacter Infections / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D016480:Helicobacter pylori; D006801:Humans; D064747:Lansoprazole / Q000008:administration & dosage; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000097:blood* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D054439:Ghrelin; D020738:Leptin; D064747:Lansoprazole; D000658:Amoxicillin; D017291:Clarithromycin
keywords: Eradication; Helicobacter pylori; Plasma Ghrelin and Leptin