title: The roles of microRNAs related with progression and metastasis in human cancers.
abstract: Metastasis is an important factor in predicting the prognosis of the patients with cancers and contributes to high cancer-related mortality. Recent studies indicated that microRNAs (miRNAs) played a functional role in the initiation and progression of human malignancies. MicroRNAs are small non-coding RNAs of about 22 nucleotides in length that can induce messenger RNA (mRNA) degradation or repress mRNA translation by binding to the 3' untranslated region (3'-UTR) of their target genes. Overwhelming reports indicated that miRNAs could regulate cancer invasion and metastasis via epithelial-to-mesenchymal transition (EMT)-related and/or non-EMT-related mechanisms. In this review, we concentrate on the underlying mechanisms of miRNAs in regulating cancer progression and metastasis.
authors.affiliation: Department of Pathology, Qilu Hospital, Shandong University, Jinan, People's Republic of China.|Department of Pathology, School of Basic Medicine, Shandong University, Jinan, People's Republic of China.
authors.forename: Hai-Ting
authors.initials: HT
authors.lastname: Liu
authors.affiliation: Department of Pathology, Qilu Hospital, Shandong University, Jinan, People's Republic of China. gaopeng@sdu.edu.cn.|Department of Pathology, School of Basic Medicine, Shandong University, Jinan, People's Republic of China. gaopeng@sdu.edu.cn.
authors.forename: Peng
authors.identifier: 0000-0002-4721-0887
authors.initials: P
authors.lastname: Gao
keywords: Cancer; EMT; EMT-TFs; Metastasis; Progression; microRNA