title: Regulation of Oligodendrocyte Differentiation and Myelination by Nuclear Receptors: Role in Neurodegenerative Disorders.
abstract: During development and through adulthood, differentiation of diverse cell types is controlled by specific genetic and molecular programs for which transcription factors are master regulators of gene expression. Here, we present an overview of the role of nuclear receptors and their selective pharmacological modulators in oligodendrocytes linage, their role in myelination and remyelination and their potential use as a therapeutic strategy for demyelinating diseases. We discuss several aspects of nuclear receptors including: (1) the biochemistry of nuclear receptors superfamily; (2) their role on stem cells physiology, focusing in differentiation and cell removal; (3) the role of nuclear receptor in the oligodendrocytes cell linage, from oligodendrocyte progenitors cells to mature myelinating cells; and (4) the therapeutics opportunities of nuclear receptors for specific demyelinating diseases.
authors.affiliation: Grupo de Neurociencias y Muerte Celular, Facultad de Medicina e Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Adrián
authors.initials: A
authors.lastname: Sandoval-Hernández
authors.affiliation: Grupo de Neurociencias y Muerte Celular, Facultad de Medicina e Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: María José
authors.initials: MJ
authors.lastname: Contreras
authors.affiliation: Grupo de Neurociencias y Muerte Celular, Facultad de Medicina e Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Jenny
authors.initials: J
authors.lastname: Jaramillo
authors.affiliation: Grupo de Neurociencias y Muerte Celular, Facultad de Medicina e Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia. gharboledab@unal.edu.co.|Departamento de Patología, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia. gharboledab@unal.edu.co.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Arboleda
mesh_terms: D000326:Adrenoleukodystrophy / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D000544:Alzheimer Disease / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D000818:Animals; D051836:COUP Transcription Factors / Q000819:agonists / Q000235:genetics / Q000378:metabolism; D002454:Cell Differentiation; D019070:Cell Lineage; D015507:Drugs, Investigational / Q000627:therapeutic use; D005786:Gene Expression Regulation; D006801:Humans; D000071518:Liver X Receptors / Q000819:agonists / Q000235:genetics / Q000378:metabolism; D018696:Neuroprotective Agents / Q000627:therapeutic use; D009836:Oligodendroglia / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D057093:Orphan Nuclear Receptors; D047492:Peroxisome Proliferator-Activated Receptors / Q000819:agonists / Q000235:genetics / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists / Q000235:genetics / Q000378:metabolism; D018168:Receptors, Retinoic Acid / Q000819:agonists / Q000235:genetics* / Q000378:metabolism; D013234:Stem Cells / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology
chemical_list: D051836:COUP Transcription Factors; D015507:Drugs, Investigational; D000071518:Liver X Receptors; C088601:NR2E1 protein, human; D018696:Neuroprotective Agents; D057093:Orphan Nuclear Receptors; D047492:Peroxisome Proliferator-Activated Receptors; D018160:Receptors, Cytoplasmic and Nuclear; D018168:Receptors, Retinoic Acid
keywords: Alzheimer’s disease; Demyelinating diseases; Nuclear receptors; Oligodendrocytes