title: Mechanisms of Benefit with Aspirin Therapy in Aspirin-Exacerbated Respiratory Disease.
abstract: Aspirin-exacerbated respiratory disease (AERD) is a clinical syndrome characterized by severe persistent asthma, hyperplastic eosinophilic sinusitis with nasal polyps, and an intolerance to aspirin and other NSAIDs that preferentially inhibit COX-1. For more than 30 years, aspirin desensitization has proven to be of significant long-term benefit in carefully selected patients with AERD. Despite this, the exact mechanisms behind the therapeutic effects of aspirin desensitization remain poorly understood. In this article, we review the current understanding of the mechanisms of aspirin desensitization and discuss future areas of investigation.
authors.affiliation: Adult Program, Division of Allergy and Immunology, National Jewish Health, University of Colorado, 1400 Jackson Street, K624, Denver, CO 80206, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Hill
authors.affiliation: Northwest Asthma and Allergy Center, 9725 3rd Avenue Northeast, Suite 500, Northgate Executive Center II, Seattle, WA 98115, USA.
authors.forename: Trever
authors.initials: T
authors.lastname: Burnett
authors.affiliation: Division of Allergy and Immunology, National Jewish Health, University of Colorado, 1400 Jackson Street, K624, Denver, CO 80206, USA. Electronic address: KatialR@NJHealth.org.
authors.forename: Rohit
authors.initials: R
authors.lastname: Katial
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000009:adverse effects*; D001241:Aspirin / Q000008:administration & dosage* / Q000009:adverse effects*; D016207:Cytokines / Q000378:metabolism; D003888:Desensitization, Immunologic / Q000379:methods; D006801:Humans; D015289:Leukotrienes / Q000235:genetics / Q000378:metabolism; D018077:Receptors, Leukotriene / Q000235:genetics / Q000378:metabolism; D012140:Respiratory Tract Diseases / Q000209:etiology* / Q000378:metabolism / Q000628:therapy*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016207:Cytokines; D015289:Leukotrienes; D018077:Receptors, Leukotriene; D001241:Aspirin
keywords: Aspirin desensitization; Aspirin-exacerbated respiratory disease (AERD); Cysteinyl leukotrienes (CysLTs); Cytokines; Interleukin 4 (IL-4); Mechanisms of action; Prostaglandin D2; Signal transducer and activator of transcription 6 (STAT6)