title: Hypertension and early menopause after the use of assisted reproductive technologies in women aged 43 years or older: Long-term follow-up study.
abstract: OBJECTIVE
  The aim of this study was to investigate the long-term consequences to women's health and the onset of menopause in healthy women of advanced reproductive age who conceived by assisted reproductive technologies (ART).
  
  
  METHODS
  Healthy women who conceived by ART (72) and controls (80) were selected among 320 women ≥ 43 years, who delivered between January 2010 and December 2011 in the Department of Gynecological and Obstetrical Sciences and Urological Sciences of "Sapienza" University of Rome. Body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), and presence of hypertension and diabetes were analyzed at three days, six months, and three years after delivery. The onset of menopause was analyzed after three years.
  
  
  RESULTS
  In the ART group, SBP, DBP and hypertension were higher at three days, six months, and three years after delivery. Menopausal age was significantly lower.
  
  
  CONCLUSIONS
  The impact of ART in healthy women of advanced reproductive age in the years after delivery is not limited to the possible development of cardiovascular risk factors, such as hypertension, but can also influence the age of onset of menopause.
authors.affiliation: Department of Gynecological and Obstetrical Sciences and Urological Sciences, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Rosato
authors.affiliation: Department of Gynecological and Obstetrical Sciences and Urological Sciences, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Perrone
authors.affiliation: Department of Gynecological and Obstetrical Sciences and Urological Sciences, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Oriana
authors.initials: O
authors.lastname: Capri
authors.affiliation: Department of Gynecological and Obstetrical Sciences and Urological Sciences, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Galoppi
authors.affiliation: Department of Gynecological and Obstetrical Sciences and Urological Sciences, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Miriam
authors.initials: M
authors.lastname: Candelieri
authors.affiliation: Department of Gynecological and Obstetrical Sciences and Urological Sciences, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Eleonora
authors.identifier: http://orcid.org/0000-0003-4397-2873
authors.initials: E
authors.lastname: Marcoccia
authors.affiliation: Department of Gynecological and Obstetrical Sciences and Urological Sciences, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Michele Carlo
authors.initials: MC
authors.lastname: Schiavi
authors.affiliation: Department of Gynecological and Obstetrical Sciences and Urological Sciences, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Zannini
authors.affiliation: Department of Gynecological and Obstetrical Sciences and Urological Sciences, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Brunelli
mesh_terms: D000328:Adult; D001794:Blood Pressure; D015992:Body Mass Index; D048909:Diabetes Complications / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D008594:Menopause, Premature; D008875:Middle Aged; D011446:Prospective Studies; D027724:Reproductive Techniques, Assisted / Q000009:adverse effects*; D012307:Risk Factors; D016387:Women's Health
keywords: advanced maternal age; assisted reproductive technologies; cardiovascular risk; hypertension; menopause