title: Label-free ratiometric electrochemical detection of the mutated apolipoprotein E gene associated with Alzheimer's disease.
abstract: A novel ratiometric electrochemical nanosensing platform was developed based on graphene and mesoporous hybrid nanomaterials for detection of the mutated apolipoprotein E gene associated with Alzheimer's disease. The introduction of ratiometric assay could cancel out some systematic errors and significantly improved the sensing performance, such as reproducibility, reliability and accuracy.
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. xqu@ciac.ac.cn and University of Chinese Academy of Sciences, Beijing, 100039, China and Department of Chemistry, University of Washington, Box 351700, Seattle, Washington 98195-1700, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Wu
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. xqu@ciac.ac.cn and University of Chinese Academy of Sciences, Beijing, 100039, China.
authors.forename: Haiwei
authors.initials: H
authors.lastname: Ji
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. xqu@ciac.ac.cn and University of Chinese Academy of Sciences, Beijing, 100039, China.
authors.forename: Hanjun
authors.initials: H
authors.lastname: Sun
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. xqu@ciac.ac.cn and University of Chinese Academy of Sciences, Beijing, 100039, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Ding
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. xqu@ciac.ac.cn.
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ren
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. xqu@ciac.ac.cn.
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Qu
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D004563:Electrochemistry / Q000379:methods*; D009154:Mutation
chemical_list: D001057:Apolipoproteins E