title: The association between runt-related transcription factor 3 gene promoter methylation and gastric cancer: A meta-analysis.
abstract: OBJECTIVE
  To systematically evaluate the relationship of the methylation of the human-runt-related transcription factor 3 (RUNX3) promoter region and gastric cancer risk through meta-analysis.
  
  
  METHODS
  The studies published in PubMed, EMBASE, Ovid, and CNKI were retrieved. The association between RUNX3 gene promoter methylation and gastric cancer was analyzed using Stata 11.0 (http://www.stata.com; Stata Corporation, College Station, TX, USA) and Review Man 5.0 software (http://ims.cochrane.org/revman/download).
  
  
  RESULTS
  Seventeen studies are included in the analysis. Meta-analysis reveals that the odds ratio of the methylation of the RUNX3 promoter region in gastric was 7.32 (95% confidence interval: 5.12-10.47), which was significant higher than the normal gastric tissues (P < 0.05).
  
  
  CONCLUSIONS
  The RUNX3 gene promoter methylation rate was much higher in tumor tissue than that in normal gastric tissue in patient with gastric cancer, which indicates a close association between gastric cancer and RUNX3 gene promoter methylation.
authors.affiliation: Department of Clinical Laboratory, First Teaching Hospital of Tianjin University of TCM, Tianjin 300193, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Clinical Laboratory, The Second People's Hospital, Tianjin 300192, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Clinical Laboratory, First Teaching Hospital of Tianjin University of TCM, Tianjin 300193, China.
authors.forename: Yongtie
authors.initials: Y
authors.lastname: Guo
mesh_terms: D050677:Core Binding Factor Alpha 3 Subunit / Q000235:genetics*; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016017:Odds Ratio; D011401:Promoter Regions, Genetic; D017594:Publication Bias; D013274:Stomach Neoplasms / Q000235:genetics*
chemical_list: D050677:Core Binding Factor Alpha 3 Subunit