title: Assessing the association between EFEMP1 rs3791679 polymorphism and risk of glioma in a Chinese Han population.
abstract: In this study, we assessed the association between the EFEMP1 rs3791679 polymorphism and glioma risk in a Chinese Han population. A total of 94 glioma patients and 206 healthy controls who conformed to the inclusion and exclusion criteria were recruited from Baogang Hospital between March 2012 and October 2014. The EFEMP1 rs3791679 gene polymorphism was assessed using a polymerase chain reaction-restriction fragment length polymorphism assay and the results were statistically analyzed using SPSS Statistics 17.0. The results of unconditional logistic regression analysis revealed that the GG genotype of EFEMP1 rs3791679 was positively correlated with increased susceptibility to glioma (adjusted OR = 2.09, 95%CI = 1.21-7.81). Moreover, the GG genotype of EFEMP1 rs3791679 was correlated with higher risk of glioma compared to the AA+GA genotype (OR = 2.60, 95%CI = 1.08-6.28) in the regressive model. In conclusion, we report that the EFEMP1 rs3791679 polymorphism influences glioma susceptibility in the Chinese Han population.
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.|Department of Neurosurgery, Baogang Hospital, Baotou, Inner Mongolia, China.
authors.forename: N
authors.initials: N
authors.lastname: Jiang
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China pengyupie@163.com.
authors.forename: Y P
authors.initials: YP
authors.lastname: Peng
authors.affiliation: Department of Neurosurgery, Baogang Hospital, Baotou, Inner Mongolia, China.
authors.forename: X Y
authors.initials: XY
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Affiliated Hospital of Inner Mongolia Medical University, Huhhot, Inner Mongolia, China.
authors.forename: C W
authors.initials: CW
authors.lastname: Dou
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: W M
authors.initials: WM
authors.lastname: He
mesh_terms: D000328:Adult; D044466:Asian People; D001932:Brain Neoplasms / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D016326:Extracellular Matrix Proteins / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D005910:Glioma / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C119630:EFEMP1 protein, human; D016326:Extracellular Matrix Proteins