title: Clinical impact of18F-FDG positron emission tomography/CT on adenoid cystic carcinoma of the head and neck.
abstract: The purpose of this retrospective study was to assess the diagnostic value of18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT and the prognostic value of metabolic PET parameters in patients with adenoid cystic carcinoma of the head and neck (ACCHN).
  
  
  
  Forty patients with newly diagnosed ACCHN were enrolled in this study. We investigated the diagnostic value of18F-FDG PET/CT for detecting and staging compared to conventional CT. Kaplan-Meier survival analysis for progression-free survival (PFS) was performed with clinicopathological factors and metabolic PET parameters.
  
  
  
  The18F-FDG PET/CT showed comparable sensitivity (92.3%) to conventional CT for lesion detection, and changed staging and management plan in 6 patients (15.0%). Lower PFS rates were associated with advanced T classification, advanced TNM classification, high maximum standardized uptake value (SUVmax; >5.1), and high total lesion glycolysis (>40.1) of the primary tumor.
  
  
  
  The18F-FDG PET/CT can provide additional information for initial staging, and metabolic PET parameters may serve as prognostic factors of ACCHN. © 2016 Wiley Periodicals, Inc. Head Neck 39: 447-455, 2017.
authors.affiliation: Department of Nuclear Medicine, Kyungpook National University Medical Center and School of Medicine, Daegu, Republic of Korea.
authors.forename: Ji-Hoon
authors.initials: JH
authors.lastname: Jung
authors.affiliation: Department of Nuclear Medicine, Kyungpook National University Medical Center and School of Medicine, Daegu, Republic of Korea.
authors.forename: Sang-Woo
authors.initials: SW
authors.lastname: Lee
authors.affiliation: Department of Nuclear Medicine, Kyungpook National University Medical Center and School of Medicine, Daegu, Republic of Korea.
authors.forename: Seung Hyun
authors.initials: SH
authors.lastname: Son
authors.affiliation: Department of Nuclear Medicine, Kyungpook National University Medical Center and School of Medicine, Daegu, Republic of Korea.
authors.forename: Choon-Young
authors.initials: CY
authors.lastname: Kim
authors.affiliation: Department of Nuclear Medicine, Kyungpook National University Medical Center and School of Medicine, Daegu, Republic of Korea.
authors.forename: Chang-Hee
authors.initials: CH
authors.lastname: Lee
authors.affiliation: Department of Nuclear Medicine, Kyungpook National University Medical Center and School of Medicine, Daegu, Republic of Korea.
authors.forename: Ju Hye
authors.initials: JH
authors.lastname: Jeong
authors.affiliation: Department of Nuclear Medicine, Kyungpook National University Medical Center and School of Medicine, Daegu, Republic of Korea.
authors.forename: Shin Young
authors.initials: SY
authors.lastname: Jeong
authors.affiliation: Department of Nuclear Medicine, Kyungpook National University Medical Center and School of Medicine, Daegu, Republic of Korea.
authors.forename: Byeong-Cheol
authors.initials: BC
authors.lastname: Ahn
authors.affiliation: Department of Nuclear Medicine, Kyungpook National University Medical Center and School of Medicine, Daegu, Republic of Korea.|DGMIF, Daegu, Republic of Korea.
authors.forename: Jaetae
authors.initials: J
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003528:Carcinoma, Adenoid Cystic / Q000000981:diagnostic imaging* / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D015331:Cohort Studies; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*; D016016:Proportional Hazards Models; D012372:ROC Curve; D011856:Radiographic Image Enhancement; D012189:Retrospective Studies; D018570:Risk Assessment; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT; adenoid cystic carcinoma; metabolic positron emission tomography (PET) parameters; progression-free survival; staging