title: Ten years since the discovery of iPS cells: The current state of their clinical application.
abstract: On the 10-year anniversary of the discovery of induced pluripotent stem cells, we review the main results from their various fields of application, the obstacles encountered during experimentation and the potential applications in clinical practice. The efficacy of induced pluripotent cells in clinical experimentation can be equated to that of human embryonic stem cells; however, unlike stem cells, induced pluripotent cells do not involve the severe ethical difficulties entailed by the need to destroy human embryos to obtain them. The finding of these cells, which was in its day a true scientific milestone worthy of a Nobel Prize in Medicine, is currently enveloped by light and shadow: high hopes for regenerative medicine versus the, as of yet, poorly controlled risks of unpredictable reactions, both in the processes of dedifferentiation and subsequent differentiation to the cell strains employed for therapeutic or experimentation goals.
authors.affiliation: Instituto de Ciencias de la Vida, Universidad Católica de Valencia, Valencia, España. Electronic address: justo.aznar@ucv.es.
authors.forename: J
authors.initials: J
authors.lastname: Aznar
authors.affiliation: Instituto de Ciencias de la Vida, Universidad Católica de Valencia, Valencia, España.
authors.forename: J
authors.initials: J
authors.lastname: Tudela
keywords: Cell reprogramming; Células iPS; Células troncales embrionarias; Embryonic stem cells; Medicina regenerativa; Regenerative medicine; Reprogramación celular; iPS cells