title: Olfactory Dysfunction in Parkinson's Disease Patients with the LRRK2 G2385R Variant.
abstract: Olfactory dysfunction has been reported in Parkinson's disease (PD) patients carrying the LRRK2 G2019S variant in Caucasians but rarely in those with the LRRK2 G2385R variant. In this study, we performed genotyping for the LRRK2 G2385R variant in PD patients recruited from the Movement Disorder Clinic of Xuanwu Hospital in Beijing and in healthy controls randomly selected from the Beijing Longitudinal Study on Aging cohort. The "five-odor olfactory detection array", an olfactory threshold test, was used to assess olfactory function. One hundred and eighty-six participants were enrolled, comprising 43 PD patients without (iPD) and 25 with (LRRK2-PD) the LRRK2 G2385R variant, and 118 healthy controls. Our results showed that the threshold of olfactory identification was significantly worse in PD patients than in controls, but not significantly different between the iPD and LRRK2-PD groups. These findings suggested that although olfactory function in LRRK2-PD patients is impaired, it is similar to that in iPD patients.
authors.affiliation: Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Cao
authors.affiliation: Parkinson Disease Center of Beijing Institute of Brain Disorders, Beijing, 100053, China.|Beijing Key Laboratory on Parkinson's Disease, Beijing, 100053, China.
authors.forename: Zhu-Qin
authors.initials: ZQ
authors.lastname: Gu
authors.affiliation: Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.|Beijing Key Laboratory on Parkinson's Disease, Beijing, 100053, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.|Beijing Key Laboratory on Parkinson's Disease, Beijing, 100053, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.
authors.forename: Xiao-Juan
authors.initials: XJ
authors.lastname: Dan
authors.affiliation: Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Cen
authors.affiliation: Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.
authors.forename: Da-Wei
authors.initials: DW
authors.lastname: Li
authors.affiliation: Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China. pbchan90@gmail.com.|Parkinson Disease Center of Beijing Institute of Brain Disorders, Beijing, 100053, China. pbchan90@gmail.com.|Beijing Key Laboratory on Parkinson's Disease, Beijing, 100053, China. pbchan90@gmail.com.
authors.forename: Piu
authors.initials: P
authors.lastname: Chan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001120:Arginine / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005998:Glycine / Q000235:genetics; D006801:Humans; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D000857:Olfaction Disorders / Q000209:etiology*; D010300:Parkinson Disease / Q000150:complications* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012684:Sensory Thresholds / Q000502:physiology
chemical_list: D001120:Arginine; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D005998:Glycine
keywords: LRRK2 G2385R variant; Olfactory dysfunction; Parkinson’s disease