title: Maternal hepatitis B surface antigen carrier status and its impact on neonatal outcomes: a cohort study of 21 947 singleton newborns in China.
abstract: OBJECTIVE
  To explore the impact of maternal hepatitis B surface antigen (HBsAg) carrier status on neonatal outcomes.
  
  
  METHODS
  A retrospective cohort study was conducted using data from medical records database of six hospitals in China. Information on maternal characteristics and selected neonatal outcomes was retrieved for all women who delivered singleton infants between 1 January 2009 and 31 December 2010.
  
  
  RESULTS
  A total of 21 947 singleton newborns and their mothers were included. The prevalence of maternal HBsAg positivity was 4.2% (95% confidence interval (CI) 3.9-4.5%). Compared with infants born to HBsAg-negative women, infants born to HBsAg-positive mothers were more than twice more likely to have a malformation before (adjusted odds ratio (aOR) 2.23, 95% CI 1.15-4.30) and at birth (aOR 2.66, 95% CI 1.38-5.14), but were less likely to be macrosomia (aOR 0.67, 95% CI 0.47-0.96). No statistically significant association was found between maternal HBsAg positivity and preterm birth (aOR 1.20, 95% CI 0.95-1.51), low birth weight (aOR 1.24, 95% CI 0.91-1.69), and Apgar scores at 1 min (aOR 0.88, 95% CI 0.49-1.57) and 5 min (aOR 1.84, 95% CI 0.89-3.81).
  
  
  CONCLUSIONS
  Maternal HBsAg positivity may be associated with a higher risk of congenital malformation.
authors.affiliation: a School of West China Public Health, Sichuan University , Chengdu , PR China.|b Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University , Chengdu , PR China.|c School of Public Health, Chengdu University of Traditional Chinese Medicine , Chengdu , PR China , and.
authors.forename: Jing
authors.initials: J
authors.lastname: Tan
authors.affiliation: c School of Public Health, Chengdu University of Traditional Chinese Medicine , Chengdu , PR China , and.
authors.forename: Shiyao
authors.initials: S
authors.lastname: Huang
authors.affiliation: d West China Women's and Children's Hospital, Sichuan University , Chengdu , PR China.
authors.forename: Guolin
authors.initials: G
authors.lastname: He
authors.affiliation: b Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University , Chengdu , PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Tang
authors.affiliation: a School of West China Public Health, Sichuan University , Chengdu , PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Ren
authors.affiliation: a School of West China Public Health, Sichuan University , Chengdu , PR China.
authors.forename: Jinghuan
authors.initials: J
authors.lastname: Zheng
authors.affiliation: d West China Women's and Children's Hospital, Sichuan University , Chengdu , PR China.
authors.forename: Xinghui
authors.initials: X
authors.lastname: Liu
authors.affiliation: b Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University , Chengdu , PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Sun
mesh_terms: D000328:Adult; D001034:Apgar Score; D002353:Carrier State; D016022:Case-Control Studies; D002681:China; D000013:Congenital Abnormalities / Q000453:epidemiology / Q000821:virology; D005260:Female; D005320:Fetal Macrosomia / Q000453:epidemiology / Q000821:virology; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006801:Humans; D007223:Infant; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood*; D011256:Pregnancy Outcome / Q000453:epidemiology*; D047928:Premature Birth / Q000453:epidemiology / Q000821:virology; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D006514:Hepatitis B Surface Antigens
keywords: HBsAg carrier status; cohort study; congenital malformation; neonatal outcome