title: Specific enrichment combined with highly efficient solid-phase tagging for the sensitive detection of heparin based on boronic acid-functionalized mesoporous silica nanospheres.
abstract: A combined specific enrichment and highly efficient solid-phase tagging approach is presented for heparin detection using boronic acid-functionalized mesoporous silica nanospheres as extraction sorbents and nanoscale reactors. It exhibits a faster reaction time (only 6 min), higher tagging-product purity and lower applicable sample concentration compared with liquid-phase tagging.
authors.affiliation: School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China. dongzhu@njucm.edu.cn yupingtang@njucm.edu.cn.
authors.forename: Dong
authors.identifier: http://orcid.org/0000-0002-4285-9011
authors.initials: D
authors.lastname: Zhu
authors.affiliation: School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China. dongzhu@njucm.edu.cn yupingtang@njucm.edu.cn.
authors.forename: Jing
authors.initials: J
authors.lastname: Ye
authors.affiliation: School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China. dongzhu@njucm.edu.cn yupingtang@njucm.edu.cn.
authors.forename: Yue
authors.initials: Y
authors.lastname: Hu
authors.affiliation: School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China. dongzhu@njucm.edu.cn yupingtang@njucm.edu.cn.
authors.forename: Hong Mei
authors.initials: HM
authors.lastname: Wen
authors.affiliation: School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China. dongzhu@njucm.edu.cn yupingtang@njucm.edu.cn.
authors.forename: An
authors.initials: A
authors.lastname: Kang
authors.affiliation: School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China. dongzhu@njucm.edu.cn yupingtang@njucm.edu.cn.
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Tang
authors.affiliation: School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China. dongzhu@njucm.edu.cn yupingtang@njucm.edu.cn.
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.affiliation: School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China. dongzhu@njucm.edu.cn yupingtang@njucm.edu.cn.
authors.forename: Chen Xiao
authors.initials: CX
authors.lastname: Shan
authors.affiliation: School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China. dongzhu@njucm.edu.cn yupingtang@njucm.edu.cn.
authors.forename: Xiao Bing
authors.initials: XB
authors.lastname: Cui