title: Systemic Therapy of Advanced/Metastatic Breast Cancer - Current Evidence and Future Concepts.
abstract: Systemic therapy of metastatic breast cancer may include chemotherapy, endocrine therapy, and targeted therapies (e.g., antibody-based approaches). These agents may be employed alone or in combination based on the patient's breast cancer subtype. Therefore, characterization of the disease phenotype is necessary and may include biopsy of the metastatic site. Novel therapeutic approaches include immunologic therapies, PARP inhibitors, PI3K inhibitors, and CDK4/6 inhibitors, which are currently under investigation in clinical trials.
authors.affiliation: Department of Gynecology and Obstetrics, University Hospital Schleswig-Holstein/Campus Lübeck, Lübeck, Germany.
authors.forename: Cornelia
authors.initials: C
authors.lastname: Liedtke
authors.affiliation: Department for Gynecology and Obstetrics, Marienhospital Bottrop.
authors.forename: Hans-Christian
authors.initials: HC
authors.lastname: Kolberg
keywords: Chemotherapy; Clinical trials; Endocrine therapy; Metastatic breast cancer; Molecular breast cancer subgroups; Targeted therapy