title: Piceatannol is superior to resveratrol in promoting neural stem cell differentiation into astrocytes.
abstract: Piceatannol (3,3',4',5-trans-tetrahydroxystilbene) is a polyphenolic compound abundant in the seeds of passion fruit (Passiflora edulis). Piceatannol is an analogue of resveratrol (3,4',5-trans-trihydroxystilbene) and shares the structural motif and biological activities such as activation of SIRT1. Several studies have shown that piceatannol is more potent than resveratrol. In this study, we examined the effects of piceatannol on neural stem cell differentiation into astrocytes compared with those of resveratrol. At a concentration of 2.5 μM, piceatannol promoted astrocyte differentiation, while resveratrol had no effect at this concentration. Furthermore, we found that oral administration of piceatannol increased the number of astrocytes in the brains of adult mice, while resveratrol administration showed no effects. These results suggest that piceatannol has a superior effect to resveratrol in promoting astrocyte differentiation.
authors.affiliation: Research Institute for Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan. arai@aoni.waseda.jp ayocha@waseda.jp.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Arai
authors.affiliation: School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan. r-kataoka.s.t@fuji.waseda.jp otsukasatoshikun@fuji.waseda.jp.
authors.forename: Ryousuke
authors.initials: R
authors.lastname: Kataoka
authors.affiliation: School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan. r-kataoka.s.t@fuji.waseda.jp otsukasatoshikun@fuji.waseda.jp.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Otsuka
authors.affiliation: School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan. r-kataoka.s.t@fuji.waseda.jp otsukasatoshikun@fuji.waseda.jp.
authors.forename: Midori
authors.initials: M
authors.lastname: Kawamura
authors.affiliation: Health Science Research Center, Morinaga & Co., Ltd, 2-1-1 Shimosueyoshi, Tsurumi-ku, Yokohama 230-8504, Japan. h-uchida-ji@morinaga.co.jp m-sai-ia@morinaga.co.jp t-ito-jj@morinaga.co.jp.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Maruki-Uchida
authors.affiliation: Health Science Research Center, Morinaga & Co., Ltd, 2-1-1 Shimosueyoshi, Tsurumi-ku, Yokohama 230-8504, Japan. h-uchida-ji@morinaga.co.jp m-sai-ia@morinaga.co.jp t-ito-jj@morinaga.co.jp.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Sai
authors.affiliation: Health Science Research Center, Morinaga & Co., Ltd, 2-1-1 Shimosueyoshi, Tsurumi-ku, Yokohama 230-8504, Japan. h-uchida-ji@morinaga.co.jp m-sai-ia@morinaga.co.jp t-ito-jj@morinaga.co.jp.
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Ito
authors.affiliation: Research Institute for Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan. arai@aoni.waseda.jp ayocha@waseda.jp and School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan. r-kataoka.s.t@fuji.waseda.jp otsukasatoshikun@fuji.waseda.jp.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakao
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000502:physiology*; D002454:Cell Differentiation / Q000187:drug effects*; D005786:Gene Expression Regulation; D006624:Hippocampus / Q000166:cytology; D008297:Male; D051379:Mice; D015394:Molecular Structure; D058953:Neural Stem Cells / Q000187:drug effects* / Q000502:physiology; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D013267:Stilbenes; C041525:3,3',4,5'-tetrahydroxystilbene; D000077185:Resveratrol