title: [The History and Development of Experimental Rodent Models of Chronic Lung Allograft Dysfunction after Lung Transplantation].
abstract: Chronic lung allograft dysfunction (CLAD) is a critical impediment to the long-term survival after lung transplantation. A rat orthotopic lung transplantation model was developed in the early 1970s, and using this model, our laboratory has shown that the immunopathogenesis of CLAD involves both allogeneic immunity and autoimmunity. However, further investigation of CLAD is limited by the scarcity of transgenic and knockout strains. The model most widely used to study CLAD, the mouse model of heterotopic tracheal transplantation, has some incomplete pathophysiologic features of CLAD, which limits the utility of this model. Unlike other solid organ transplants, vascularized and aerated murine lung transplantation has only recently been developed. We have also reported that minor, but not major, histocompatibility antigens mismatch induced the development of CLAD in murine orthotopic lung transplants and that CLAD development was interleukin-17-dependent. This mini-review underscores the history and development of rodent models of CLAD after lung transplant, including the findings from our previous studies. In addition, the future direction of rodent models is also discussed.
authors.affiliation: Department of General Thoracic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
authors.forename: Hidemi
authors.initials: H
authors.lastname: Suzuki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hata
authors.forename: Yuki
authors.initials: Y
authors.lastname: Shina
authors.forename: Takamasa
authors.initials: T
authors.lastname: Yun
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Tanaka
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Sakairi
authors.forename: Hironobu
authors.initials: H
authors.lastname: Wada
authors.forename: Taiki
authors.initials: T
authors.lastname: Fujiwara
authors.forename: Takahiro
authors.initials: T
authors.lastname: Nakajima
authors.forename: Takekazu
authors.initials: T
authors.lastname: Iwata
authors.forename: Masako
authors.initials: M
authors.lastname: Chiyo
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Yoshida
authors.forename: Ichiro
authors.initials: I
authors.lastname: Yoshino
mesh_terms: D000818:Animals; D006801:Humans; D008171:Lung Diseases / Q000503:physiopathology*; D016040:Lung Transplantation; D023421:Models, Animal; D012129:Respiratory Function Tests; D012377:Rodentia; D014184:Transplantation, Homologous