title: Modulatory Mechanism of Nociceptive Neuronal Activity by Dietary Constituent Resveratrol.
abstract: Changes to somatic sensory pathways caused by peripheral tissue, inflammation or injury can result in behavioral hypersensitivity and pathological pain, such as hyperalgesia. Resveratrol, a plant polyphenol found in red wine and various food products, is known to have several beneficial biological actions. Recent reports indicate that resveratrol can modulate neuronal excitability, including nociceptive sensory transmission. As such, it is possible that this dietary constituent could be a complementary alternative medicine (CAM) candidate, specifically a therapeutic agent. The focus of this review is on the mechanisms underlying the modulatory effects of resveratrol on nociceptive neuronal activity associated with pain relief. In addition, we discuss the contribution of resveratrol to the relief of nociceptive and/or pathological pain and its potential role as a functional food and a CAM.
authors.affiliation: Laboratory of Food and Physiological Sciences, Department of Life and Food Sciences, School of Life and Environmental Sciences, Azabu University, 1-17-71, Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan. m-takeda@azabu-u.ac.jp.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Takeda
authors.affiliation: Laboratory of Food and Physiological Sciences, Department of Life and Food Sciences, School of Life and Environmental Sciences, Azabu University, 1-17-71, Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan. me1605@azabu-u.ac.jp.
authors.forename: Shiori
authors.initials: S
authors.lastname: Takehana
authors.affiliation: Laboratory of Food and Physiological Sciences, Department of Life and Food Sciences, School of Life and Environmental Sciences, Azabu University, 1-17-71, Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan. che.4.mar29@gmail.com.
authors.forename: Kenta
authors.initials: K
authors.lastname: Sekiguchi
authors.affiliation: FANCL Health Science Research Center, Research Institute, FANCL corporation, 12-13, Kamishinano, Totsuka-ku, Yokohama, Kanagawa 244-0806, Japan. yoshiko_0909@fancl.co.jp.
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Kubota
authors.affiliation: Laboratory of Food and Physiological Sciences, Department of Life and Food Sciences, School of Life and Environmental Sciences, Azabu University, 1-17-71, Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan. shimazu@azabu-u.ac.jp.
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Shimazu
mesh_terms: D000818:Animals; D019587:Dietary Supplements; D007249:Inflammation; D009619:Nociceptors / Q000187:drug effects*; D059408:Pain Management; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D013267:Stilbenes; D000077185:Resveratrol
keywords: complementary alternative medicine; extracellular single unit recording; hyperalgesia; nociceptive neuron; resveratrol; trigeminal spinal nucleus; trigeminal system