title: Measurement of Neuropsychiatric Symptoms in Clinical Trials Targeting Alzheimer's Disease and Related Disorders.
abstract: Behavioral and psychological symptoms (BPSD) are now known to be frequently associated to cognitive and functional decline in Alzheimer's disease and related disorders. They are present since the early stages of the disease and have negative impact on the disease process. BPSD assessment is crucial in clinical practice and also in future clinical trials targeting disease-modifying therapies for dementia. In this article, we will first review current assessment tools for BPSD, mainly global and domain-specific scales, and new assessment methods, currently available or in development, including new scales, diagnostic criteria and new technologies such as ambulatory actigraphy.
authors.affiliation: Centre Mémoire de Ressources et de Recherche/Hôpital de Cimiez, 4 av Reine Victoria, 06000 Nice, France. david.r@chu-nice.fr.
authors.forename: Renaud
authors.initials: R
authors.lastname: David
authors.affiliation: Centre Mémoire de Ressources et de Recherche/Hôpital de Cimiez, 4 av Reine Victoria, 06000 Nice, France. mulin.e@chu-nice.fr.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Mulin
authors.affiliation: Centre d'Innovation et d'Usage en Santé (CIU-S) / Hôpital de Cimiez, 4 av Reine Victoria, 06000 Nice, France. mallea.p@chu-nice.fr.
authors.forename: Patrick
authors.initials: P
authors.lastname: Mallea
authors.affiliation: Centre Mémoire de Ressources et de Recherche/Hôpital de Cimiez, 4 av Reine Victoria, 06000 Nice, France. robert.ph@chu-nice.fr.|Centre d'Innovation et d'Usage en Santé (CIU-S) / Hôpital de Cimiez, 4 av Reine Victoria, 06000 Nice, France. robert.ph@chu-nice.fr.
authors.forename: Philippe H
authors.initials: PH
authors.lastname: Robert
keywords: Alzheimer’s disease; actigraphy; assessment tools; clinical trials; neuropsychiatric symptoms