title: Molecular basis of human cerebral malaria development.
abstract: Cerebral malaria is still a deleterious health problem in tropical countries. The wide spread of malarial drug resistance and the lack of an effective vaccine are obstacles for disease management and prevention. Parasite and human genetic factors play important roles in malaria susceptibility and disease severity. The malaria parasite exerted a potent selective signature on the human genome, which is apparent in the genetic polymorphism landscape of genes related to pathogenesis. Currently, much genomic data and a novel body of knowledge, including the identification of microRNAs, are being increasingly accumulated for the development of laboratory testing cassettes for cerebral malaria prevention. Therefore, understanding of the underlying complex molecular basis of cerebral malaria is important for the design of strategy for cerebral malaria treatment and control.
authors.affiliation: Department of Clinical Microscopy, Faculty of Medical Technology, Mahidol University, Bangkok, 10700 Thailand.
authors.forename: Saw Thu
authors.initials: ST
authors.lastname: Wah
authors.affiliation: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
authors.forename: Hathairad
authors.initials: H
authors.lastname: Hananantachai
authors.affiliation: Department of Chemistry, Faculty of Science, Naresuan University, Phitsanulok, 65000 Thailand.
authors.forename: Usanee
authors.initials: U
authors.lastname: Kerdpin
authors.affiliation: Department of Clinical Microscopy, Faculty of Medical Technology, Mahidol University, Bangkok, 10700 Thailand ; Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.
authors.forename: Chotiros
authors.initials: C
authors.lastname: Plabplueng
authors.affiliation: Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.
authors.forename: Virapong
authors.initials: V
authors.lastname: Prachayasittikul
authors.affiliation: Department of Clinical Microscopy, Faculty of Medical Technology, Mahidol University, Bangkok, 10700 Thailand ; Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.
authors.forename: Pornlada
authors.initials: P
authors.lastname: Nuchnoi
keywords: Cerebral malaria; Genetics; MicroRNA; Pathogenesis