title: Analysis of negative result in serum anti-H. pyloriIgG antibody test in cases with gastric mucosal atrophy.
abstract: The purpose is to elucidate factors related to negative results of anti-H. pyloriantibody test in cases with gastric mucosal atrophy. A total of 859 individuals without past history of eradication therapy forH. pylori(545 males, 314 females; mean age 52.4 years) who underwent an upper GI endoscopy examination and serological test were enrolled as subjects. Serological testing was performed using SphereLightH. pyloriantibody J®, and endoscopic findings of gastric mucosal atrophy by the classification of Kimura and Takemoto and post-eradication findings were analyzed. The positive rates for the anti-H. pyloriantibody test in subjects with and without gastric mucosal atrophy were 85.6% and 0.9%, respectively. In analysis of subjects with gastric mucosal atrophy, a low positive rate and serum titer was observed in subjects with C1, C2 and O3 atrophy. When the analysis was performed separately in male and female subjects, low positive rate was observed in males with O3 atrophy and females with C2 atrophy. Suspected post-eradication endoscopic findings were more frequently observed in cases with C2 atrophy. In conclusion, negative result of anti-H. pyloriantibody test was frequently observed in middle-aged subjects with C1, C2 and O3 gastric mucosal atrophy.
authors.affiliation: Health Center, Shimane Environment and Health Public Corporation, Koshibara 1-4-6, Matsue, Shimane 690-0012, Japan.
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Adachi
authors.affiliation: Health Center, Shimane Environment and Health Public Corporation, Koshibara 1-4-6, Matsue, Shimane 690-0012, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Mishiro
authors.affiliation: Health Center, Shimane Environment and Health Public Corporation, Koshibara 1-4-6, Matsue, Shimane 690-0012, Japan.
authors.forename: Shino
authors.initials: S
authors.lastname: Tanaka
authors.affiliation: Second Department of Internal Medicine, Shimane University Faculty of Medicine, Enya-cho 89-1, Izumo, Shimane 693-8501, Japan.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kinoshita
keywords: Helicobacter pylori; atrophy; diagnosis; endoscopy; serologic tests