title: Development, validation and application of a device to measure e-cigarette users' puffing topography.
abstract: With the rapidly rising popularity and substantial evolution of electronic cigarettes (e-cigarettes) in the past 5-6 years, how these devices are used by vapers and consumers' exposure to aerosol emissions need to be understood. We used puffing topography to measure directly product use. We adapted a cigarette puffing topography device for use with e-cigarettes. We performed validation using air and e-cigarette aerosol under multiple regimes. Consumer puffing topography was measured for 60 vapers provided with rechargeable "cig-a-like" or larger button-activated e-cigarettes, to use ad-libitum in two sessions. Under all regimes, air puff volumes were within 1 mL of the target and aerosol volumes within 5 mL for all device types, serving to validate the device. Vapers' mean puff durations (2.0 s and 2.2 s) were similar with both types of e-cigarette, but mean puff volumes (52.2 mL and 83.0 mL) and mean inter-puff intervals (23.2 s and 29.3 s) differed significantly. The differing data show that product characteristics influence puffing topography and, therefore, the results obtained from a given e-cigarette might not read across to other products. Understanding the factors that affect puffing topography will be important for standardising testing protocols for e-cigarette emissions.
authors.affiliation: Research and Development, British American Tobacco (Investments) Ltd., Regents Park Road, Southampton SO15 8TL, United Kingdom.
authors.forename: Anthony
authors.initials: A
authors.lastname: Cunningham
authors.affiliation: Research and Development, British American Tobacco (Investments) Ltd., Regents Park Road, Southampton SO15 8TL, United Kingdom.
authors.forename: Sandra
authors.initials: S
authors.lastname: Slayford
authors.affiliation: Research and Development, British American Tobacco (Investments) Ltd., Regents Park Road, Southampton SO15 8TL, United Kingdom.
authors.forename: Carl
authors.initials: C
authors.lastname: Vas
authors.affiliation: Research and Development, British American Tobacco (Investments) Ltd., Regents Park Road, Southampton SO15 8TL, United Kingdom.
authors.forename: Jodie
authors.initials: J
authors.lastname: Gee
authors.affiliation: Nicoventures Holdings Ltd., Globe House, 1 Water Street, London WC2R 3LA, United Kingdom.
authors.forename: Sandra
authors.initials: S
authors.lastname: Costigan
authors.affiliation: Research and Development, British American Tobacco (Investments) Ltd., Regents Park Road, Southampton SO15 8TL, United Kingdom.
authors.forename: Krishna
authors.initials: K
authors.lastname: Prasad
mesh_terms: D000336:Aerosols / Q000737:chemistry / Q000494:pharmacology*; D066300:Electronic Nicotine Delivery Systems; D006801:Humans; D019570:Inhalation Exposure; D009538:Nicotine / Q000737:chemistry; D012907:Smoking; D062789:Tobacco Products
chemical_list: D000336:Aerosols; D009538:Nicotine