title: A randomized double-blind placebo-controlled crossover trial of sodium nitrate in patients with stable angina INAS.
abstract: In an aging western population, a significant number of patients continue to suffer from angina once all revascularization and optimal medical treatment options are exhausted. Under experimental conditions, oral supplementation with inorganic nitrate was shown to exhibit a blood pressure-lowering effect, and has also been shown to promote angiogenesis, improve endothelial dysfunction and mitochondrial efficiency in skeletal muscle. It is unknown whether similar changes occur in cardiac muscle. In the current study, we investigate whether oral sodium nitrate treatment will improve myocardial ischemia in patients with stable angina.
authors.affiliation: School of Medicine & Dentistry, University of Aberdeen, Aberdeen, UK.|Worcestershire Royal Hospital, Worcester, UK.
authors.forename: Konstantin
authors.initials: K
authors.lastname: Schwarz
authors.affiliation: School of Medicine & Dentistry, University of Aberdeen, Aberdeen, UK.
authors.forename: Satnam
authors.initials: S
authors.lastname: Singh
authors.affiliation: School of Medicine & Dentistry, University of Aberdeen, Aberdeen, UK.|Norwich Medical School, University of East Anglia, Bob Champion Research & Education Building James Watson Road, Norwich, NR4 7UQ, UK.
authors.forename: Satish Kumar
authors.initials: SK
authors.lastname: Parasuraman
authors.affiliation: School of Medicine & Dentistry, University of Aberdeen, Aberdeen, UK.
authors.forename: Maggie
authors.initials: M
authors.lastname: Bruce
authors.affiliation: Norwich Medical School, University of East Anglia, Bob Champion Research & Education Building James Watson Road, Norwich, NR4 7UQ, UK.
authors.forename: Lee
authors.initials: L
authors.lastname: Shepstone
authors.affiliation: University of Southampton, Southampton, UK.
authors.forename: Martin
authors.initials: M
authors.lastname: Feelisch
authors.affiliation: University of Southampton, Southampton, UK.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Minnion
authors.affiliation: Aston Medical Research Institute, Aston Medical School, Aston University, Birmingham, B4 7ET, UK.
authors.forename: Shakil
authors.initials: S
authors.lastname: Ahmad
authors.affiliation: School of Medicine & Dentistry, University of Aberdeen, Aberdeen, UK.|University of Adelaide, Adelaide, Australia.
authors.forename: John
authors.initials: J
authors.lastname: Horowitz
authors.affiliation: School of Medicine & Dentistry, University of Aberdeen, Aberdeen, UK.
authors.forename: Dana K
authors.initials: DK
authors.lastname: Dawson
authors.affiliation: School of Medicine & Dentistry, University of Aberdeen, Aberdeen, UK.|Norwich Medical School, University of East Anglia, Bob Champion Research & Education Building James Watson Road, Norwich, NR4 7UQ, UK.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Frenneaux
mesh_terms: D000284:Administration, Oral; D000368:Aged; D060050:Angina, Stable / Q000188:drug therapy*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005080:Exercise Test; D006801:Humans; D017202:Myocardial Ischemia / Q000188:drug therapy*; D009566:Nitrates / Q000008:administration & dosage*
chemical_list: D009566:Nitrates; C031618:sodium nitrate
keywords: angina; inorganic nitrate; randomized controlled trial