title: Physical exercise induces hippocampal neurogenesis and prevents cognitive decline.
abstract: Accumulating evidence from animal and human research indicate that adult hippocampal neurogenesis plays a key role in cognition. Meanwhile, cognitive decline is well known to associate with ageing-related neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). Therefore, prevention of hippocampal neurogenesis reduction should be critical for these diseases. Physical exercise, a potent enhancer of adult hippocampal neurogenesis, has emerged as a potential therapy or an adjunctive therapeutic strategy for cognitive decline. In this review, we discuss the recent findings on hippocampal neurogenesis and the incorporation of new born neurons into the neuronal network in humans and in rodents. By focusing on hippocampal neurogenesis, we illustrate the role and possible mechanisms of physical exercise in cognition preservation.
authors.affiliation: Graduate School, Wuhan Sports University, Wuhan 430079, China; School of Sports Science and Technology, Wuhan Sports University, Wuhan, 430205,China.
authors.forename: Chun-Lian
authors.initials: CL
authors.lastname: Ma
authors.affiliation: Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurological Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong,524001, China.
authors.forename: Xiao-Tang
authors.initials: XT
authors.lastname: Ma
authors.affiliation: Department of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH 45435, USA.
authors.forename: Jin-Ju
authors.initials: JJ
authors.lastname: Wang
authors.affiliation: College of Health Science, Wuhan Sports University, Wuhan, 430079, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH 45435, USA.
authors.forename: Yan-Fang
authors.initials: YF
authors.lastname: Chen
authors.affiliation: College of Health Science, Wuhan Sports University, Wuhan, 430079, China. Electronic address: yangyi999999@yahoo.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000818:Animals; D003072:Cognition Disorders / Q000517:prevention & control*; D015444:Exercise; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D006801:Humans; D009415:Nerve Net / Q000502:physiology; D055495:Neurogenesis / Q000502:physiology*
keywords: Aging; Brain plasticity; Cognition; Exercise; Neurodegenerative disease; Neurogenesis