title: Anti-inflammatory effects of Salvia plebeia R. Br extract in vitro and in ovalbumin-induced mouse model.
abstract: BACKGROUND
  Asthma is an increasing global health problem, and novel strategies to prevent or ameliorate the condition are needed. Here, the effects of 80 % ethanol extracts of Salvia plebeia R. Br. (SE) on an induced inflammatory response were investigated.
  
  
  RESULTS
  Salvia plebeia R. Br. inhibited production of pro-inflammatory cytokines, such as TNF-α and IL-6, as well as nitric oxide (NO) in LPS-stimulated RAW 264.7 cells. NO and pro-inflammatory cytokine production was suppressed more effectively by SE of the aerial parts (SE-A) than of the roots (SE-R) of S. plebeia. In BEAS-2B cells, both SE-A and SE-R inhibited the increase in production of the inflammatory cytokines IL-6 and IL-8. We also investigated the anti-asthmatic effects of SE in an ovalbumin (OVA)-induced BALB/c mouse model. SE-A treatment significantly reduced the number of airway eosinophils, IL-4 and IL-13 levels, mucus production, and inflammatory infiltration, as compared with the corresponding levels in the untreated, OVA-induced mice, and had similar effects to dexamethasone.
  
  
  CONCLUSIONS
  Salvia plebeia ethanol extract ameliorated the induced inflammatory response in RAW 264.7 and BEAS-2B cells, with more effective inhibition noted for SE-A than for SE-R. SE-A treatment was effective in improving the histopathological changes in the lungs of asthma model mice via modulation of eosinophils and Th2 cytokines. These results suggest that SE-A can be considered as a therapeutic agent that can potentially relieve asthma.
authors.affiliation: Functional Food & Nutrition Division, National Institute of Agricultural Science, Rural Development Administration (RDA), Wanju, 565-851, South Korea.
authors.forename: Hwan-Hee
authors.initials: HH
authors.lastname: Jang
authors.affiliation: Functional Food & Nutrition Division, National Institute of Agricultural Science, Rural Development Administration (RDA), Wanju, 565-851, South Korea.
authors.forename: Su-Yeon
authors.initials: SY
authors.lastname: Cho
authors.affiliation: Functional Food & Nutrition Division, National Institute of Agricultural Science, Rural Development Administration (RDA), Wanju, 565-851, South Korea.
authors.forename: Mi-Ju
authors.initials: MJ
authors.lastname: Kim
authors.affiliation: Functional Food & Nutrition Division, National Institute of Agricultural Science, Rural Development Administration (RDA), Wanju, 565-851, South Korea.
authors.forename: Jung-Bong
authors.initials: JB
authors.lastname: Kim
authors.affiliation: Functional Food & Nutrition Division, National Institute of Agricultural Science, Rural Development Administration (RDA), Wanju, 565-851, South Korea.
authors.forename: Sung-Hyen
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Herbal Medicine EBM Research Center, Korea Institute of Oriental Medicine, Daejeon, 305-811, South Korea.
authors.forename: Mee-Young
authors.initials: MY
authors.lastname: Lee
authors.affiliation: Department of Food and Nutrition, Seoul Women's University, Seoul, 139-774, South Korea. ymlee@swu.ac.kr.
authors.forename: Young-Min
authors.initials: YM
authors.lastname: Lee
mesh_terms: D000818:Animals; D018927:Anti-Asthmatic Agents / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001249:Asthma / Q000139:chemically induced / Q000188:drug therapy*; D001892:Camphanes; D002478:Cells, Cultured; D016207:Cytokines / Q000032:analysis / Q000187:drug effects; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004797:Enzyme-Linked Immunosorbent Assay; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D008070:Lipopolysaccharides / Q000494:pharmacology; D008168:Lung / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D009569:Nitric Oxide / Q000032:analysis; D010047:Ovalbumin; D053723:Panax notoginseng; D035261:Plant Components, Aerial / Q000737:chemistry; D000067996:RAW 264.7 Cells; D060888:Real-Time Polymerase Chain Reaction; D015203:Reproducibility of Results; D027561:Salvia miltiorrhiza
chemical_list: D018927:Anti-Asthmatic Agents; D000893:Anti-Inflammatory Agents; D001892:Camphanes; D016207:Cytokines; D004365:Drugs, Chinese Herbal; D008070:Lipopolysaccharides; C000604051:danshen dripping pill; D009569:Nitric Oxide; D000431:Ethanol; D010047:Ovalbumin
keywords: Anti-inflammatory; Asthma; Salvia plebeia