title: Five years update on relationships between malignant pleural mesothelioma and exposure to asbestos and other elongated mineral particles.
abstract: Despite the reduction of global asbestos consumption and production due to the ban or restriction of asbestos uses in more than 50 countries since the 1970s, malignant mesothelioma remains a disease of concern. Asbestos is still used, imported, and exported in several countries, and the number of mesothelioma deaths may be expected to increase in the next decades in these countries. Asbestos exposure is the main risk factor for malignant pleural mesothelioma, but other types of exposures are linked to the occurrence of this type of cancer. Although recent treatments improve the quality of life of patients with mesothelioma, malignant pleural mesothelioma remains an aggressive disease. Recent treatments have not resulted in appreciable improvement in survival, and thus development of more efficient therapies is urgently needed. The development of novel therapeutic strategies is dependent on our level of knowledge of the physiopathological and molecular changes that mesothelial cells acquired during the neoplastic process. During the past 5 years, new findings have been published on the etiology, epidemiology, molecular changes, and innovative treatments of malignant pleural mesothelioma. This review aims to update the findings of recent investigations on etiology, epidemiology, and molecular changes with a focus on (1) attributable risk of asbestos exposure in men and women and (2) coexposure to other minerals and other elongated mineral particles or high aspect ratio nanoparticles. Recent data obtained on genomic and gene alterations, pathways deregulations, and predisposing factors are summarized.
authors.affiliation: a Institut Santé Travail Paris-Est , Université Paris-Est , Créteil , France.|b CHI Créteil , Service de Pneumologie et Pathologie Professionnelle, DHU A-TVB , Créteil , France.|c INSERM U955 , Equipe 4 , Créteil , France.|d Universite Paris-Est Créteil , Faculté de Médecine , Créteil , France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Andujar
authors.affiliation: e INSERM U1219 , EPICENE , Bordeaux , France.|f ISPED , Université de Bordeaux , Bordeaux , France.
authors.forename: Aude
authors.initials: A
authors.lastname: Lacourt
authors.affiliation: f ISPED , Université de Bordeaux , Bordeaux , France.|g CHU Bordeaux , Bordeaux , France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Brochard
authors.affiliation: a Institut Santé Travail Paris-Est , Université Paris-Est , Créteil , France.|b CHI Créteil , Service de Pneumologie et Pathologie Professionnelle, DHU A-TVB , Créteil , France.|c INSERM U955 , Equipe 4 , Créteil , France.|d Universite Paris-Est Créteil , Faculté de Médecine , Créteil , France.
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Pairon
authors.affiliation: h INSERM , UMR-1162, Génomique fonctionnelle des tumeurs solides , Paris , France.|i Université Paris Descartes , Labex Immuno-Oncology , Sorbonne Paris Cité, Paris , France.|j Université Paris Diderot , IUH , Paris , France.|k Université Paris 13 , Sorbonne Paris Cité , Bobigny , France.
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Jaurand
authors.affiliation: h INSERM , UMR-1162, Génomique fonctionnelle des tumeurs solides , Paris , France.|i Université Paris Descartes , Labex Immuno-Oncology , Sorbonne Paris Cité, Paris , France.|j Université Paris Diderot , IUH , Paris , France.|k Université Paris 13 , Sorbonne Paris Cité , Bobigny , France.
authors.forename: Didier
authors.initials: D
authors.lastname: Jean
mesh_terms: D001194:Asbestos / Q000633:toxicity*; D004781:Environmental Exposure; D006801:Humans; D008175:Lung Neoplasms / Q000139:chemically induced / Q000453:epidemiology / Q000235:genetics; D008654:Mesothelioma / Q000139:chemically induced / Q000453:epidemiology / Q000235:genetics; D000086002:Mesothelioma, Malignant; D008903:Minerals / Q000633:toxicity; D053758:Nanoparticles / Q000633:toxicity*; D016273:Occupational Exposure; D010997:Pleural Neoplasms / Q000139:chemically induced / Q000453:epidemiology / Q000235:genetics
chemical_list: D008903:Minerals; D001194:Asbestos