title: Comparison of simultaneous and sequential administration of fentanyl-propofol for surgical abortion: a randomized single-blinded controlled trial.
abstract: Propofol lipid emulsion (PLE) is a nanosized sedative, and it is used with a combination of salted antalgic prodrug, fentanyl citrate (FC). To illustrate the synergistic effect of mixing, we compared the sedation/analgesia resulting from simultaneous and sequential administration in surgically induced abortion (No. ChiCTR-IPC-15006153). Simultaneous group showed lower bispectral index, blood pressure, and heart rate, when cannula was inserted into the uterus. It also showed less frequency of hypertension, sinus tachycardia, movement, pain at the injection site, and additional FC. Therefore, premixing of PLE and FC enhanced the sedation and analgesia; stabilized the hemodynamics; lessened the incidence of movement and injection pain; and reduced the requirement of drugs.
authors.affiliation: a Department of Anesthesiology , The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
authors.affiliation: b School of Basic Medical Science, Xi'an Medical University , Xi'an , P.R. China.
authors.forename: Baoyong
authors.initials: B
authors.lastname: Sha
authors.affiliation: a Department of Anesthesiology , The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , P.R. China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: a Department of Anesthesiology , The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , P.R. China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Fan
authors.affiliation: a Department of Anesthesiology , The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , P.R. China.
authors.forename: Lin
authors.initials: L
authors.lastname: Liu
authors.affiliation: a Department of Anesthesiology , The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , P.R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Shen
mesh_terms: D000028:Abortion, Induced; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D056805:Consciousness Monitors; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology*; D011247:Pregnancy; D015742:Propofol / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D006993:Hypnotics and Sedatives; D005283:Fentanyl; D015742:Propofol
keywords: Fentanyl; analgesia; lipid emulsion; propofol; sedation; surgical abortion