title: Screw-actuated displacement micropumps for thermoplastic microfluidics.
abstract: The fabrication of on-chip displacement pumps integrated into thermoplastic chips is explored as a simple and low cost method for achieving precise and programmable flow control for disposable microfluidic systems. The displacement pumps consist of stainless steel screws inserted into threaded ports machined into a thermoplastic substrate which also serve as on-chip reagent storage reservoirs. Three different methods for pump sealing are investigated to enable high pressure flows without leakage, and software-defined control of multiple pumps is demonstrated in a self-contained platform using a compact and self-contained microcontroller for operation. Using this system, flow rates ranging from 0.5-40 μl min-1are demonstrated. The pumps are combined with on-chip burst valves to fully seal multiple reagents into fabricated chips while providing on-demand fluid distribution in a downstream microfluidic network, and demonstrated for the generation of size-tunable water-in-oil emulsions.
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, MD 20742, USA. ddev@umd.edu.
authors.forename: J Y
authors.initials: JY
authors.lastname: Han
authors.affiliation: Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
authors.forename: O D
authors.initials: OD
authors.lastname: Rahmanian
authors.affiliation: Department of Mechanical Engineering, University of Maryland, College Park, MD 20742, USA.
authors.forename: E L
authors.initials: EL
authors.lastname: Kendall
authors.affiliation: Department of Mechanical Engineering, University of Maryland, College Park, MD 20742, USA.
authors.forename: N
authors.initials: N
authors.lastname: Fleming
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, MD 20742, USA. ddev@umd.edu and Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA and Department of Mechanical Engineering, University of Maryland, College Park, MD 20742, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: DeVoe
mesh_terms: D004867:Equipment Design; D056656:Lab-On-A-Chip Devices; D010969:Plastics; D012984:Software; D013696:Temperature
chemical_list: D010969:Plastics