title: Left Atrial trajectory impairment in Hypertrophic Cardiomyopathy disclosed by Geometric Morphometrics and Parallel Transport.
abstract: The analysis of full Left Atrium (LA) deformation and whole LA deformational trajectory in time has been poorly investigated and, to the best of our knowledge, seldom discussed in patients with Hypertrophic Cardiomyopathy. Therefore, we considered 22 patients with Hypertrophic Cardiomyopathy (HCM) and 46 healthy subjects, investigated them by three-dimensional Speckle Tracking Echocardiography, and studied the derived landmark clouds via Geometric Morphometrics with Parallel Transport. Trajectory shape and trajectory size were different in Controls versus HCM and their classification powers had high AUC (Area Under the Receiving Operator Characteristic Curve) and accuracy. The two trajectories were much different at the transition between LA conduit and booster pump functions. Full shape and deformation analyses with trajectory analysis enabled a straightforward perception of pathophysiological consequences of HCM condition on LA functioning. It might be worthwhile to apply these techniques to look for novel pathophysiological approaches that may better define atrio-ventricular interaction.
authors.affiliation: Dipartimento di Ingegneria Strutturale e Geotecnica, Sapienza Università di Roma, Roma, Italy.|Dipartimento di Scienze Cardiovascolari, Respiratorie, Nefrologiche, Anestesiologiche e Geriatriche, Sapienza Università di Roma, Roma, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Piras
authors.affiliation: Dipartimento di Scienze Cardiovascolari, Respiratorie, Nefrologiche, Anestesiologiche e Geriatriche, Sapienza Università di Roma, Roma, Italy.
authors.forename: Concetta
authors.initials: C
authors.lastname: Torromeo
authors.affiliation: Centro per le Cardiomiopatie Ospedale S. Camillo-Forlanini, Roma, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Re
authors.affiliation: Ospedale San Giovanni Calibita Fatebenefratelli Isola Tiberina, Roma, Italy.
authors.forename: Antonietta
authors.initials: A
authors.lastname: Evangelista
authors.affiliation: Dipartimento di Architettura, Università Roma Tre, Roma, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Gabriele
authors.affiliation: Dipartimento di Scienze Cardiovascolari, Respiratorie, Nefrologiche, Anestesiologiche e Geriatriche, Sapienza Università di Roma, Roma, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Esposito
authors.affiliation: Dipartimento di Ingegneria Strutturale e Geotecnica, Sapienza Università di Roma, Roma, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Nardinocchi
authors.affiliation: Dipartimento di Matematica e Fisica, LaMS-Modeling &Simulation Lab, Università Roma Tre, Roma, Italy.
authors.forename: Luciano
authors.initials: L
authors.lastname: Teresi
authors.affiliation: Dipartimento di Scienze Cardiovascolari, Respiratorie, Nefrologiche, Anestesiologiche e Geriatriche, Sapienza Università di Roma, Roma, Italy.|Centro per le Cardiomiopatie Ospedale S. Camillo-Forlanini, Roma, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Madeo
authors.affiliation: Centro per le Cardiomiopatie Ospedale S. Camillo-Forlanini, Roma, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Chialastri
authors.affiliation: Dipartimento di Scienze Cardiovascolari, Respiratorie, Nefrologiche, Anestesiologiche e Geriatriche, Sapienza Università di Roma, Roma, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Schiariti
authors.affiliation: Dipartimento di Architettura, Università Roma Tre, Roma, Italy.
authors.forename: Valerio
authors.initials: V
authors.lastname: Varano
authors.affiliation: Centro per le Cardiomiopatie Ospedale S. Camillo-Forlanini, Roma, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Uguccioni
authors.affiliation: Dipartimento di Ingegneria Strutturale e Geotecnica, Sapienza Università di Roma, Roma, Italy.
authors.forename: Paolo E
authors.initials: PE
authors.lastname: Puddu
mesh_terms: D000328:Adult; D016279:Atrial Function, Left / Q000502:physiology; D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology*; D016022:Case-Control Studies; D019560:Echocardiography, Three-Dimensional; D005260:Female; D006325:Heart Atria / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D021621:Imaging, Three-Dimensional; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D060388:Support Vector Machine