title: Graft Transit Time Has No Effect on Outcome of Unrelated Donor Hematopoietic Cell Transplants Performed in Australia and New Zealand: A Study from the Australasian Bone Marrow Transplant Recipient Registry.
abstract: A previous study found that platelet recovery and mortality were worse in recipients of myeloablative bone marrow transplants where graft transit times were longer than 20 hours. This retrospective study of unrelated myeloablative allogeneic transplantation performed within Australia and New Zealand analyzed transplant outcomes according to graft transit times. Of 233 assessable cases, 76 grafts (33%) were sourced from bone marrow (BM) and 157 (67%) from peripheral blood. Grafts sourced from Australia and New Zealand (47% of total) were associated with a median transit time of 6 hours versus 32 hours for overseas sourced grafts (53% of total). Graft transit temperature was refrigerated in 85%, ambient in 6%, and unknown in 9% of cases, respectively. Graft transit times had no significant effect on neutrophil or platelet engraftment, treatment-related mortality, overall survival, and incidence of acute or chronic graft-versus-host disease. Separate analysis of BM grafts, although of reduced power, also showed no significant difference in either neutrophil or platelet engraftment or survival between short and longer transport times. This study gives reassurance that both peripheral blood stem cell and especially BM grafts subjected to long transit times and transported at refrigerated temperatures may not be associated with adverse recipient outcomes.
authors.affiliation: Department of Haematology, Auckland City Hospital, Auckland, New Zealand. Electronic address: npatton@adhb.govt.nz.
authors.forename: William Nigel
authors.initials: WN
authors.lastname: Patton
authors.affiliation: Australasian Bone Marrow Transplant Recipient Registry, St. Vincent's Hospital, Darlinghurst, New South Wales, Australia.
authors.forename: Ian
authors.initials: I
authors.lastname: Nivison-Smith
authors.affiliation: Royal Adelaide Hospital, Adelaide, South Australia, Australia.
authors.forename: Peter
authors.initials: P
authors.lastname: Bardy
authors.affiliation: Department of Haematology & Stem Cell Transplant, St. Vincent's Hospital, Darlinghurst, New South Wales, Australia.
authors.forename: Anthony
authors.initials: A
authors.lastname: Dodds
authors.affiliation: Department of Haematology & Stem Cell Transplant, St. Vincent's Hospital, Darlinghurst, New South Wales, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Ma
authors.affiliation: Children's Hospital at Westmead, Sydney, New South Wales, Australia.
authors.forename: Peter John
authors.initials: PJ
authors.lastname: Shaw
authors.affiliation: Department of Haematology, Westmead Hospital, Sydney, New South Wales, Australia.
authors.forename: John
authors.initials: J
authors.lastname: Kwan
authors.affiliation: Australasian Bone Marrow Transplant Recipient Registry, St. Vincent's Hospital, Darlinghurst, New South Wales, Australia.
authors.forename: Leonie
authors.initials: L
authors.lastname: Wilcox
authors.affiliation: Canterbury Health Laboratories, Christchurch, New Zealand.
authors.forename: Andrew
authors.initials: A
authors.lastname: Butler
authors.affiliation: Department of Haematology, Wellington Hospital, Wellington, New Zealand.
authors.forename: John M
authors.initials: JM
authors.lastname: Carter
authors.affiliation: New Zealand Bone Marrow Donor Registry, Auckland, New Zealand.
authors.forename: Hilary
authors.initials: H
authors.lastname: Blacklock
authors.affiliation: Clinical Haematology and Bone Marrow Transplant Service, Royal Melbourne Hospital, Parkville, Victoria, Australia.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Szer
mesh_terms: D000293:Adolescent; D000328:Adult; D001315:Australia; D016026:Bone Marrow Transplantation / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006085:Graft Survival; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009520:New Zealand; D012042:Registries; D012189:Retrospective Studies; D013696:Temperature; D013997:Time Factors; D014186:Transportation; D055815:Young Adult
keywords: ABMTRR Australasian Bone Marrow Transplant Recipient Registry; Anticoagulant acid citrate dextrose solution; HSCT hematopoietic stem cell transplantation; World Marrow Donor Association