title: Chikungunya Virus Infection and Diabetes Mellitus: A Double Negative Impact.
abstract: The impact of chikungunya virus (CHIKV) infection on diabetic patients (DPs) has not been described. We aimed to compare clinical features of CHIKV infection in DPs and nondiabetic patients (NDPs), and to evaluate its effects on glycemic control among DPs. We recorded clinical information and, in DPs, glycemic control. Forty-six DPs and 53 NDPs aged ≥ 20 years living in Haiti, with acute CHIKV infection, were studied. Diabetes duration was 7.1 ± 6.1 years. The most common acute CHIKV clinical manifestations were arthralgia (100.0% DPs and 98.1% NDPs, P = 1.000) and fever (86.9% DPs and 90.5% NDPs, P = 0.750). In DPs as compared with NDPs, arthralgia was more intense (mean pain score of 6.0/10 ± 2.2 versus 5.1/10 ± 2.0, P = 0.04) and took longer to improve (8.2 ± 3.0 versus 3.5 ± 2.5 days, P < 0.0001). Severe arthralgia was more prevalent (58.7% versus 20.8%, P = 0.0002), as was myalgia (80.4% versus 50.9%, P = 0.003), and fever lasted longer (5.1 ± 1.8 versus 3.7 ± 1.7 days, P = 0.0002). Among DPs, median fasting capillary glucose before versus after disease onset was 132.5 and 167.5 mg/dL (P < 0.001), corresponding to a median increase of 26.8% (interquartile range: 14.4-50.1%). Antidiabetic medication was titrated up in 41.3%. In summary, among DPs, CHIKV infection has a significant negative impact on glycemic control and, compared with NDPs, results in greater morbidity. Close clinical and glycemic observation is recommended in DPs with CHIKV infection.
authors.affiliation: FHADIMAC (Haitian Foundation of Diabetes and Cardiovascular Diseases), Port-au-Prince, Haiti.
authors.forename: Eddy
authors.initials: E
authors.lastname: Jean-Baptiste
authors.affiliation: Division of Pediatric Endocrinology, Montreal Children's Hospital, Montreal, Canada.
authors.forename: Julia
authors.initials: J
authors.lastname: von Oettingen
authors.affiliation: FHADIMAC (Haitian Foundation of Diabetes and Cardiovascular Diseases), Port-au-Prince, Haiti.
authors.forename: Philippe
authors.initials: P
authors.lastname: Larco
authors.affiliation: FHADIMAC (Haitian Foundation of Diabetes and Cardiovascular Diseases), Port-au-Prince, Haiti.
authors.forename: Frédérica
authors.initials: F
authors.lastname: Raphaël
authors.affiliation: FHADIMAC (Haitian Foundation of Diabetes and Cardiovascular Diseases), Port-au-Prince, Haiti.
authors.forename: Nancy Charles
authors.initials: NC
authors.lastname: Larco
authors.affiliation: FHADIMAC (Haitian Foundation of Diabetes and Cardiovascular Diseases), Port-au-Prince, Haiti.
authors.forename: Marie Marcelle
authors.initials: MM
authors.lastname: Cauvin
authors.affiliation: FHADIMAC (Haitian Foundation of Diabetes and Cardiovascular Diseases), Port-au-Prince, Haiti.
authors.forename: René
authors.initials: R
authors.lastname: Charles
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose; D016022:Case-Control Studies; D065632:Chikungunya Fever / Q000453:epidemiology* / Q000473:pathology* / Q000821:virology; D002646:Chikungunya virus; D003920:Diabetes Mellitus / Q000097:blood / Q000453:epidemiology*; D005260:Female; D006205:Haiti; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose