title: Mitochondrial Diseases: Shortcuts to Therapies and Therapeutic Shortcuts.
abstract: In this issue of Molecular Cell, Barrow et al. (2016) use two complementary approaches-one an assessment of a chemical library, and the other a genome-wide CRISPR screen-that both identify bromodomain-containing protein 4 (Brd4) as a therapeutic target for mtDNA diseases affecting complex I.
authors.affiliation: MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK. Electronic address: mpm@mrc-mbu.cam.ac.uk.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Murphy
mesh_terms: D001569:Benzodiazepines / Q000494:pharmacology*; D018797:Cell Cycle Proteins; D002459:Cell Fusion; D002460:Cell Line; D003574:Cytochrome c Group / Q000235:genetics* / Q000378:metabolism; D042967:Electron Transport Complex I / Q000172:deficiency / Q000235:genetics*; D003576:Electron Transport Complex IV; D005786:Gene Expression Regulation; D057166:High-Throughput Screening Assays; D006801:Humans; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D028361:Mitochondrial Diseases / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D024101:Mitochondrial Proteins / Q000235:genetics* / Q000378:metabolism; D009687:Nuclear Proteins / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / Q000235:genetics / Q000378:metabolism; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D015398:Signal Transduction; D014157:Transcription Factors / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D000092468:Bromodomain Containing Proteins
chemical_list: D001569:Benzodiazepines; D018797:Cell Cycle Proteins; D003574:Cytochrome c Group; D042967:Electron Transport Complex I; D003576:Electron Transport Complex IV; D024101:Mitochondrial Proteins; D009687:Nuclear Proteins; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D014157:Transcription Factors; C441289:BRD4 protein, human; D000092468:Bromodomain Containing Proteins; C486497:PPARGC1A protein, human; C554645:molibresib; C576944:COX5A protein, human