title: Hippocampography Guides Consistent Mesial Resections in Neocortical Temporal Lobe Epilepsy.
abstract: Background.The optimal surgery in lesional neocortical temporal lobe epilepsy is unknown. Hippocampal electrocorticography maximizes seizure freedom by identifying normal-appearing epileptogenic tissue for resection and minimizes neuropsychological deficit by limiting resection to demonstrably epileptogenic tissue. We examined whether standardized hippocampal electrocorticography (hippocampography) guides resection for more consistent hippocampectomy than unguided resection in conventional electrocorticography focused on the lesion.Methods. Retrospective chart reviews any kind of electrocorticography (including hippocampography) as part of combined lesionectomy, anterolateral temporal lobectomy, and hippocampectomy over 8 years . Patients were divided into mesial (i.e., hippocampography) and lateral electrocorticography groups. Primary outcome was deviation from mean hippocampectomy length.Results.Of 26 patients, fourteen underwent hippocampography-guided mesial temporal resection. Hippocampography was associated with 2.6 times more consistent resection. The range of hippocampal resection was 0.7 cm in the mesial group and 1.8 cm in the lateral group (p= 0.01). 86% of mesial group versus 42% of lateral group patients achieved seizure freedom (p= 0.02).Conclusions. By rationally tailoring excision to demonstrably epileptogenic tissue, hippocampography significantly reduces resection variability for more consistent hippocampectomy than unguided resection in conventional electrocorticography. More consistent hippocampal resection may avoid overresection, which poses greater neuropsychological risk, and underresection, which jeopardizes postoperative seizure freedom.
authors.affiliation: Section of Neurology, Department of Internal Medicine, Health Sciences Centre, University of Manitoba, Winnipeg, MB, Canada.
authors.forename: Marcus C
authors.identifier: 0000-0002-6258-5943
authors.initials: MC
authors.lastname: Ng
authors.affiliation: Clinical Neurophysiology, Beaumont Hospital, Dublin, Ireland.
authors.forename: Ronan
authors.initials: R
authors.lastname: Kilbride
authors.affiliation: Epilepsy Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Mirela
authors.initials: M
authors.lastname: Simon
authors.affiliation: Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Emad
authors.initials: E
authors.lastname: Eskandar
authors.affiliation: Epilepsy Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Andrew J
authors.identifier: 0000-0002-0828-826X
authors.initials: AJ
authors.lastname: Cole