title: Inflammatory F2-isoprostane, prostaglandin F2α, pentraxin 3 levels and breast cancer risk: The Swedish Mammography Cohort.
abstract: Breast cancer is a common cancer among women. Identifying cellular participation of F2-isoprostane, prostaglandin F2α(PGF2α) and pentraxin 3 (PTX3) in cancer we evaluated whether their prediagnostic systemic levels that originate from different inflammatory pathways were associated with breast cancer risk.
  
  
  
  Seventy-eight breast cancer cases diagnosed after blood collection and 797 controls from the Swedish Mammography Cohort were analysed for urinary F2-isoprostane, PGF2αand plasma PTX3 levels.
  
  
  
  None of the biomarkers investigated were significantly associated with breast cancer risk. However, there was the suggestion of an inverse association with PTX3 with multivariable adjusted ORs (95% CI) of 0.56 (95% CI=0.29-1.06) and 0.67 (95% CI=0.35-1.28) for the second and third tertiles, respectively (ptrend=0.20). No associations were observed between F2-isoprostane (OR=0.87; 95% CI=0.48-1.57; ptrend=0.67) and PGF2αmetabolite (OR=1.03; 95% CI=0.56-1.88; ptrend=0.91) comparing the top to bottom tertiles.
  
  
  
  The systemic levels of F2-isoprostane, PGF2αand PTX3 witnessed in women who later developed breast cancer may not provide prognostic information regarding tumor development in spite of their known involvement in situ cellular context. These observations may indicate that other mechanisms exist in controlling cellular formation of F2-isoprostane, PGF2αand PTX3 and their systemic availability in breast cancer patients.
authors.affiliation: Chaire d'Excellence Program, Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, CRNH-Auvergne, INRA-UDA, Clermont-Ferrand, France; Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala University, Uppsala, Sweden.
authors.forename: Samar
authors.initials: S
authors.lastname: Basu
authors.affiliation: Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden; Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA; Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
authors.forename: Holly
authors.initials: H
authors.lastname: Harris
authors.affiliation: Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
authors.forename: Alicja
authors.initials: A
authors.lastname: Wolk
authors.affiliation: Chaire d'Excellence Program, Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, CRNH-Auvergne, INRA-UDA, Clermont-Ferrand, France.
authors.forename: Adrien
authors.initials: A
authors.lastname: Rossary
authors.affiliation: Chaire d'Excellence Program, Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, CRNH-Auvergne, INRA-UDA, Clermont-Ferrand, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Caldefie-Chézet
authors.affiliation: Chaire d'Excellence Program, Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, CRNH-Auvergne, INRA-UDA, Clermont-Ferrand, France; Centre Jean Perrin, Unicancer, Clermont-Ferrand, France; CHU Clermont-Ferrand, Unité d'Exploration Nutritionnelle, Clermont-Ferrand, France.
authors.forename: Marie-Paule
authors.initials: MP
authors.lastname: Vasson
authors.affiliation: Department of Medical Science, Faculty of Medicine, Uppsala University, Uppsala, Sweden.
authors.forename: Anders
authors.initials: A
authors.lastname: Larsson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000652:urine; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D015237:Dinoprost / Q000652:urine*; D028441:F2-Isoprostanes / Q000652:urine*; D005260:Female; D006801:Humans; D011379:Prognosis; D012307:Risk Factors; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D013548:Sweden; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D015237:Dinoprost; D028441:F2-Isoprostanes; D000683:Serum Amyloid P-Component; D000099153:Pentraxins
keywords: Breast cancer; Cancer risk; F(2)-isoprostane; Inflammation; Pentraxin; Prostaglandin F(2)(α)