title: Fetal safety profile of aromatase inhibitors: Animal data.
abstract: Aromatase inhibitors (AIs) are a class of drugs that act by blocking the production of estrogens from androgens. The current review concentrates on the prenatal developmental toxicity of AIs in experimental models. Available data indicate that AIs may affect pregnancy at human therapeutic or lower doses. The window of vulnerability to AIs is not limited to organogenesis, but also includes the preimplantation stage and fetal periods. Decreased embryo/fetal survival was the prominent treatment-related effect. Morphological anomalies noted in fetuses exposed to AIs included skeletal anomalies, abnormal head morphology, increased ano-genital distance in female fetuses, and minor urinary tract system anomalies. Placental enlargement was consistently reported in rats and non-human primates after maternal treatment with several AIs. In conclusion, data from basic scientific research suggest that low intensity exposure to AIs applied during a wide gestational window can profoundly affect prenatal development.
authors.affiliation: Department of Medicine and Aging Sciences, University "G. d'Annunzio" of Chieti-Pescara, Italy. Electronic address: tiboni@unich.it.
authors.forename: Gian Mario
authors.initials: GM
authors.lastname: Tiboni
authors.affiliation: Department of Medicine and Aging Sciences, University "G. d'Annunzio" of Chieti-Pescara, Italy. Electronic address: adalisa@hotmail.it.
authors.forename: Adalisa
authors.initials: A
authors.lastname: Ponzano
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000818:Animals; D047072:Aromatase Inhibitors / Q000633:toxicity*; D005260:Female; D047109:Fetal Development / Q000187:drug effects; D005333:Fetus / Q000002:abnormalities / Q000187:drug effects*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy
chemical_list: D047072:Aromatase Inhibitors
keywords: Animal models; Aromatase inhibitors; Pregnancy; Prenatal developmental toxicity; Teratogenesis