title: Enlightening the Cerebellopontine Angle: Intraoperative Indocyanine Green Angiography in Microvascular Decompression for Trigeminal Neuralgia.
abstract: Background and Study AimsIn microvascular decompression of the trigeminal nerve for trigeminal neuralgia (TN), the site of conflict is occasionally difficult to identify. Endoscopy has been described to better evaluate the anatomical conflict in such situations. We hypothesized that indocyanine green (ICG) angiography could allow for better visualization of the compressing artery and its anatomical relation to the nerve.Material and MethodsICG angiography was performed in 17 TN patients undergoing microvascular decompression. We focused on whether ICG angiography is helpful in determining the site of conflict, particularly when not directly visible via the microscope, and whether fluorescence is strong enough to shine through the nerve obliterating the direct view of the compressing vessel.ResultsIn four patients, the site of conflict was immediately apparent after opening the cerebellopontine cistern, and ICG angiography did not provide the neurosurgeon with additional information. In another two patients, imaging quality and fluorescence were too poor. Of the remaining 11 patients with a hidden site of nerve-vessel conflict, ICG angiography was found to be helpful in anticipating the site of compression and the course of the artery in 7 patients, particularly in regard to the so-called shining-through effect through fiber bundles of the thinned nerve. Of all the patients, 88% reported at least improvement or cessation of their symptoms, including all of the patients with a shine-through effect.ConclusionICG angiography could be a helpful adjunct in decompressing the trigeminal nerve and can guide the surgeon to the nerve-vessel conflict. Intensity of the fluorescence is powerful enough to shine through thinned and splayed trigeminal nerve fiber bundles.
authors.affiliation: Department of Neurosurgery, Universitätsmedizin Göttingen, Göttingen, Germany.
authors.forename: Kajetan L
authors.initials: KL
authors.lastname: von Eckardstein
authors.affiliation: Department of Neurosurgery, Universitätsmedizin Göttingen, Göttingen, Germany.
authors.forename: Dorothee
authors.initials: D
authors.lastname: Mielke
authors.affiliation: Department of Neurosurgery, Universitätsmedizin Göttingen, Göttingen, Germany.
authors.forename: Reza
authors.initials: R
authors.lastname: Akhavan-Sigari
authors.affiliation: Department of Neurosurgery, Universitätsmedizin Göttingen, Göttingen, Germany.
authors.forename: Veit
authors.initials: V
authors.lastname: Rohde
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002530:Cerebellopontine Angle / Q000000981:diagnostic imaging / Q000601:surgery*; D002533:Cerebral Angiography / Q000379:methods*; D005260:Female; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D061145:Microvascular Decompression Surgery / Q000379:methods*; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D016896:Treatment Outcome; D014276:Trigeminal Nerve / Q000000981:diagnostic imaging / Q000601:surgery*; D014277:Trigeminal Neuralgia / Q000000981:diagnostic imaging / Q000601:surgery*
chemical_list: D007208:Indocyanine Green