title: Can curcumin modulate allergic rhinitis in rats?
abstract: OBJECTIVE
  This study aimed to explore the effects of curcumin on experimental allergic rhinitis in rats.
  
  
  METHODS
  Twenty-eight male Wistar albino rats were randomly divided into four groups: a control group; a group in which allergic rhinitis was induced and no treatment given; a group in which allergic rhinitis was induced followed by treatment with azelastine hydrochloride on days 21-28; and a group in which allergic rhinitis was induced followed by treatment with curcumin on days 21-28. Allergy symptoms and histopathological features of the nasal mucosa were examined.
  
  
  RESULTS
  The sneezing and nasal congestion scores were higher in the azelastine and curcumin treatment groups than in the control group. Histopathological examination showed focal goblet cell metaplasia on the epithelial surface in the azelastine group. In the curcumin group, there was a decrease in goblet cell metaplasia in the epithelium, decreased inflammatory cell infiltration and vascular proliferation in the lamina propria.
  
  
  CONCLUSIONS
  Curcumin is an effective treatment for experimentally induced allergic rhinitis in rats.
authors.affiliation: ENT,Yunus Emre State Hospital,Eskişehir,Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Acar
authors.affiliation: ENT Department,Medical Faculty,Kırıkkale University,Turkey.
authors.forename: N Bayar
authors.initials: NB
authors.lastname: Muluk
authors.affiliation: Department of Pharmacology,Eskişehir Osmangazi University,Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Yigitaslan
authors.affiliation: Pathology Clinics,Yunus Emre State Hospital,Eskişehir,Turkey.
authors.forename: B P
authors.initials: BP
authors.lastname: Cengiz
authors.affiliation: Department of Anatomy,Eskişehir Osmangazi University,Turkey.
authors.forename: P
authors.initials: P
authors.lastname: Shojaolsadati
authors.affiliation: Department of Biochemistry,Eskişehir Osmangazi University,Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Karimkhani
authors.affiliation: ENT Department,Luleburgaz State Hospital,Ankara,Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Ada
authors.affiliation: Pharmaceutical Biotechnology Department,Faculty of Pharmacy,Yüzüncü Yıl University,Van,Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Berkoz
authors.affiliation: Department of ENT,Eskişehir Osmangazi University,Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Cingi
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D019902:Chondrocytes / Q000187:drug effects / Q000473:pathology; D002923:Cilia / Q000187:drug effects / Q000473:pathology; D003474:Curcumin / Q000494:pharmacology*; D004804:Eosinophils / Q000187:drug effects; D020397:Goblet Cells / Q000187:drug effects* / Q000473:pathology; D006940:Hyperemia; D006984:Hypertrophy; D008297:Male; D008407:Mast Cells / Q000187:drug effects; D008679:Metaplasia; D009297:Nasal Mucosa / Q000187:drug effects* / Q000473:pathology; D010047:Ovalbumin / Q000009:adverse effects; D010793:Phthalazines / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D065631:Rhinitis, Allergic / Q000473:pathology*; D012912:Sneezing / Q000187:drug effects*
chemical_list: D018926:Anti-Allergic Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010793:Phthalazines; D010047:Ovalbumin; D003474:Curcumin; C020976:azelastine
keywords: Allergic; Curcumin; Perennial; Rats; Rhinitis