title: Lifestyle modification intervention improves glycemic control in Mongolian adults who are overweight or obese with newly diagnosed type 2 diabetes.
abstract: OBJECTIVE
  To evaluate the effectiveness of a weight loss intervention in Mongolian adults with newly diagnosed type 2 diabetes mellitus and with BMIs ≥ 25.0 kg/m2.
  
  
  METHODS
  Eighty participants (33 men/47 women) aged 32-56 years old received education sessions to improve nutritional habits and increase physical activity. Participants were counselled in-person on two occasions with regular follow-up by phone to eat less (reduce calorie intake by 30-40% and consume fewer fatty foods), shift food intake to earlier in a day and increase physical activity such as walking, jogging, running and biking. Measurements were performed before and after the 6-month intervention.
  
  
  RESULTS
  After 6 months, the average weight loss was 4.3 ± 4.7 kg, representing a 4.9 ± 5.4% reduction in body weight (p< 0.0001). Mean HbA1c decreased from 8.5 ± 2.7% to 6.0 ± 1.8% (p< 0.0001), and the percent of individuals with HbA1c in the diabetic range dropped from 76.3% to 27.5%. These changes were accompanied by marked improvements in cardiovascular risk factors, including total cholesterol (3.92 ± 1.02 to 3.13 ± 0.80 mmol/l;p< 0.0001) and triglycerides (2.11 ± 0.82 to 1.54 ± 0.51 mmol/l;p< 0.0001), and modest reductions in systolic and diastolic blood pressure (p< 0.05).
  
  
  CONCLUSIONS
  The remarkable improvement in glycemic control and lipid profile in participants suggests that a lifestyle modification intervention targeting weight loss may be highly effective for early diabetes treatment and prevention in Mongolians.
authors.affiliation: Department of Endocrinology School of Medicine, National University of Medical Sciences Ulaanbaatar Mongolia.
authors.forename: S
authors.initials: S
authors.lastname: Sonomtseren
authors.affiliation: Department of Endocrinology State Central Clinical Hospital Ulaanbaatar Mongolia.
authors.forename: Y
authors.initials: Y
authors.lastname: Sankhuu
authors.affiliation: Pennington Biomedical Research Center Louisiana State University System Baton Rouge LA USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Warfel
authors.affiliation: Pennington Biomedical Research Center Louisiana State University System Baton Rouge LA USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Johannsen
authors.affiliation: Pennington Biomedical Research Center Louisiana State University System Baton Rouge LA USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Peterson
authors.affiliation: Pennington Biomedical Research Center Louisiana State University System Baton Rouge LA USA.
authors.forename: B
authors.initials: B
authors.lastname: Vandanmagsar
keywords: Diabetic by HbA1c; T2DM; obesity; risk factors of diabetes; weight loss; weight management; weight management intervention in Mongolians