title: Increased basal ganglia binding of18F-AV-1451 in patients with progressive supranuclear palsy.
abstract: Progressive supranuclear palsy (PSP) is difficult to diagnose accurately. The recently developed tau PET tracers may improve the diagnostic work-up of PSP.
  
  
  
  Regional tau accumulation was studied using18F-AV-1451 PET in 11 patients with PSP and 11 age-matched healthy controls in the Swedish BioFinder study.
  
  
  
  18F-AV-1451 standard uptake volume ratios were significantly higher in the basal ganglia in PSP patients when compared with controls (globus pallidus 1.75 vs 1.50; putamen 1.51 vs 1.35). Retention in the basal ganglia was correlated with age in both groups (r = .43-.78, P < .05). In PSP, we observed a significant correlation between clinical deterioration measured with the PSP rating scale and standard uptake volume ratios in the globus pallidus (r = .74, P < .05). However, no18F-AV-1451 retention was observed in the cerebral cortex or white matter of either PSP patients or controls, and autoradiography did not reveal any specific binding of AV-1451 to PSP tau aggregates.
  
  
  
  We found higher18F-AV-1451 retention in the basal ganglia of PSP patients when compared with healthy elderly controls, but also increases with age in both controls and patients. As a result of the overlap in retention between diagnostic groups and the age-dependent increase present also in controls,18F-AV-1451 PET might not reliably distinguish individual patients with PSP from controls. However, further studies are needed to evaluate whether18F-AV-1451 PET might be useful as a progression marker in clinical PSP trials. © The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
authors.affiliation: Skåne University Hospital, Department of Neurology, Lund, Sweden.
authors.forename: Ruben
authors.initials: R
authors.lastname: Smith
authors.affiliation: Lund University, Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Malmö, Sweden.
authors.forename: Martin
authors.initials: M
authors.lastname: Schain
authors.affiliation: Skåne University Hospital, Department of Neurology, Lund, Sweden.|Lund University, Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Malmö, Sweden.
authors.forename: Christer
authors.initials: C
authors.lastname: Nilsson
authors.affiliation: Lund University, Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Malmö, Sweden.
authors.forename: Olof
authors.initials: O
authors.lastname: Strandberg
authors.affiliation: Skåne University Hospital, Department of Radiation Physics, Lund, Sweden.
authors.forename: Tomas
authors.initials: T
authors.lastname: Olsson
authors.affiliation: Skåne University Hospital, Department of Clinical Neurophysiology, Lund, Sweden.
authors.forename: Douglas
authors.initials: D
authors.lastname: Hägerström
authors.affiliation: Skåne University Hospital, Department of Clinical Physiology and Nuclear Medicine, Lund, Sweden.
authors.forename: Jonas
authors.initials: J
authors.lastname: Jögi
authors.affiliation: Roche Pharmaceutical Research and Early Development, Neuroscience Discovery & Biomarkers, Roche Innovation Center, Basel, Switzerland.
authors.forename: Edilio
authors.initials: E
authors.lastname: Borroni
authors.affiliation: Lund University, Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Malmö, Sweden.|MedTech West and the University of Gothenburg, Department of Clinical Neuroscience, Gothenburg, Sweden.
authors.forename: Michael
authors.initials: M
authors.lastname: Schöll
authors.affiliation: Roche Pharmaceutical Research and Early Development, Neuroscience Discovery & Biomarkers, Roche Innovation Center, Basel, Switzerland.
authors.forename: Michael
authors.initials: M
authors.lastname: Honer
authors.affiliation: Lund University, Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Malmö, Sweden.|Skåne University Hospital, Memory Clinic, Malmö, Sweden.
authors.forename: Oskar
authors.initials: O
authors.lastname: Hansson
mesh_terms: D000367:Age Factors; D000368:Aged; D001479:Basal Ganglia / Q000000981:diagnostic imaging / Q000378:metabolism*; D002243:Carbolines; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000378:metabolism*; D006801:Humans; D049268:Positron-Emission Tomography; D013494:Supranuclear Palsy, Progressive / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology*; D013548:Sweden; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D002243:Carbolines; D016875:tau Proteins; C000591008:7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole
keywords: Progressive supranuclear palsy; basal ganglia; positron emission tomography; tau