title: [Extracorporeal treatment of hemolytic complications in multifield surgical clinic].
abstract: OBJECTIVE
  to optimize the protocol of high-volume plasmapheresis for hemolytic complications in surgical practice.
  
  
  METHODS
  We studied 100 patients aged 7-73 years with hemolytic complications. In 83 patients with free hemoglobin level over 200 mg% 50-300% of plasma volume was removed. In 32 patients (15 of them with plasmapheresis and 17 without it) renal function was assessed comparatively. Plasmapheresis was used in case of significantly higher values of hemolysis (p<0.01).
  
  
  RESULTS
  Cardiac patients make 95% of observations. They had intraoperative hemolysis due to plonged extracorporeal circulation (93) and injection of 16-18-day blood preserved with glugjcirum into pump oxygenator (2). Hemolytic complications were observed in 5 patients. Autoerythrocytes disintegration occurred in 95 cases. Efficacy of plasmapheresis to eliminate free hemoglobin was 95%. Severity of acute renal injury depended on hymolysis intensity. Renal function recovery was diagnosed in 2-3 days postoperatively. Plasmapheresis facilitated microalbuminuria and concentration function restoration.
authors.affiliation: Petrovsky Russian Research Center of Surgery, Moscow, Russia.
authors.forename: I N
authors.initials: IN
authors.lastname: Solov'yova
authors.affiliation: Petrovsky Russian Research Center of Surgery, Moscow, Russia.
authors.forename: Yu A
authors.initials: YA
authors.lastname: Morozov
authors.affiliation: Petrovsky Russian Research Center of Surgery, Moscow, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Charnaya
authors.affiliation: Petrovsky Russian Research Center of Surgery, Moscow, Russia.
authors.forename: E R
authors.initials: ER
authors.lastname: Charchyan
authors.affiliation: Petrovsky Russian Research Center of Surgery, Moscow, Russia.
authors.forename: Yu V
authors.initials: YV
authors.lastname: Belov
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D000328:Adult; D000368:Aged; D002648:Child; D005112:Extracorporeal Circulation / Q000379:methods*; D005260:Female; D006402:Hematologic Diseases / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D006454:Hemoglobins / Q000032:analysis; D006461:Hemolysis; D006801:Humans; D007431:Intraoperative Complications / Q000097:blood / Q000175:diagnosis / Q000628:therapy; D007677:Kidney Function Tests / Q000379:methods; D008297:Male; D010956:Plasmapheresis / Q000379:methods*; D011183:Postoperative Complications / Q000097:blood / Q000175:diagnosis / Q000628:therapy; D013514:Surgical Procedures, Operative / Q000009:adverse effects* / Q000145:classification / Q000379:methods; D016896:Treatment Outcome
chemical_list: D006454:Hemoglobins