title: Vascular- and hepato-protective effects of passion fruit seed extract containing piceatannol in chronic high-fat diet-fed rats.
abstract: The effects of chronic administration of piceatannol-enriched (9.5% w/w) passion fruit seed extract (PFSE) on the cardiovascular damage induced in a high-fat (HF) diet-fed model of Fischer 344 rats were evaluated. Rats were fed the control, HF, or HF diets containing PFSE (0.5% w/w) for 16 weeks, and the effects of the various diets on the tissue weight, serum lipid profile, hepatic fibrosis, hepatic ductular reaction, cardiac function and aortic ring reactivity were examined. HF diet-fed rats developed signs of cardiovascular disease with abnormal serum profiles compared to control diet-fed rats. PFSE supplementation improved the liver hypertrophy and hepatic histology of the HF diet-fed rats. In addition, the triglyceride and cholesterol levels, platelet aggregation, cardiac function, and acetylcholine-mediated relaxation of the aortic ring were improved. These results suggest that the chronic intake of PFSE containing piceatannol prevents HF diet-induced cardiovascular disease in rats.
authors.affiliation: Division of Theoretical Nursing and Pathophysiology, Yamagata University School of Medicine, 2-2-2 Iida Nishi, Yamagata 990-9585, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Ishihata
authors.affiliation: Research Institute, Morinaga & Co., Ltd., 2-1-1 Shimosueyoshi, Tsurumi-ku, Yokohama 230-8504, Japan. h-uchida-ji@morinaga.co.jp.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Maruki-Uchida
authors.affiliation: Division of Theoretical Nursing and Pathophysiology, Yamagata University School of Medicine, 2-2-2 Iida Nishi, Yamagata 990-9585, Japan.
authors.forename: Nozomi
authors.initials: N
authors.lastname: Gotoh
authors.affiliation: Division of Theoretical Nursing and Pathophysiology, Yamagata University School of Medicine, 2-2-2 Iida Nishi, Yamagata 990-9585, Japan.
authors.forename: Sumika
authors.initials: S
authors.lastname: Kanno
authors.affiliation: Division of Theoretical Nursing and Pathophysiology, Yamagata University School of Medicine, 2-2-2 Iida Nishi, Yamagata 990-9585, Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Aso
authors.affiliation: Division of Theoretical Nursing and Pathophysiology, Yamagata University School of Medicine, 2-2-2 Iida Nishi, Yamagata 990-9585, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Togashi
authors.affiliation: Research Institute, Morinaga & Co., Ltd., 2-1-1 Shimosueyoshi, Tsurumi-ku, Yokohama 230-8504, Japan. h-uchida-ji@morinaga.co.jp.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Sai
authors.affiliation: Research Institute, Morinaga & Co., Ltd., 2-1-1 Shimosueyoshi, Tsurumi-ku, Yokohama 230-8504, Japan. h-uchida-ji@morinaga.co.jp.
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Ito
authors.affiliation: Division of Theoretical Nursing and Pathophysiology, Yamagata University School of Medicine, 2-2-2 Iida Nishi, Yamagata 990-9585, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Katano
mesh_terms: D000818:Animals; D001011:Aorta / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D059305:Diet, High-Fat / Q000009:adverse effects; D019587:Dietary Supplements / Q000032:analysis; D006352:Heart Ventricles / Q000473:pathology / Q000503:physiopathology; D000960:Hypolipidemic Agents / Q000032:analysis / Q000737:chemistry / Q000627:therapeutic use*; D008082:Lipotropic Agents / Q000032:analysis / Q000737:chemistry / Q000627:therapeutic use*; D008099:Liver / Q000473:pathology; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D009929:Organ Size; D029598:Passiflora / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D010975:Platelet Aggregation Inhibitors / Q000032:analysis / Q000737:chemistry / Q000627:therapeutic use; D011897:Random Allocation; D011916:Rats, Inbred F344; D012639:Seeds / Q000737:chemistry; D013267:Stilbenes / Q000032:analysis / Q000627:therapeutic use; D014655:Vascular Resistance
chemical_list: D000960:Hypolipidemic Agents; D008082:Lipotropic Agents; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D013267:Stilbenes; C041525:3,3',4,5'-tetrahydroxystilbene