title: Copolymer-Mediated Cell Aggregation Promotes a Proangiogenic Stem Cell Phenotype In Vitro and In Vivo.
abstract: Material-induced cell aggregation drives a proangiogenic expression profile. Copolymer substrates containing cell-repellent and cell-adhesive domains force the aggregation of human mesenchymal stem cells, which results in enhanced tubulogenesis in vitro and stabilization of vasculature in vivo. These findings can be used to design instructive biomaterial scaffolds for clinical use.
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
authors.forename: Spencer W
authors.initials: SW
authors.lastname: Crowder
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Balikov
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Boire
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
authors.forename: Devin
authors.initials: D
authors.lastname: McCormack
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
authors.forename: Jung Bok
authors.initials: JB
authors.lastname: Lee
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
authors.forename: Mukesh K
authors.initials: MK
authors.lastname: Gupta
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
authors.forename: Melissa C
authors.initials: MC
authors.lastname: Skala
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.|Severance Biomedical Science Institute, College of Medicine, Yonsei University, Seoul, 120-752, Republic of Korea.
authors.forename: Hak-Joon
authors.initials: HJ
authors.lastname: Sung
mesh_terms: D001672:Biocompatible Materials / Q000008:administration & dosage*; D002449:Cell Aggregation / Q000187:drug effects*; D002478:Cells, Cultured; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000187:drug effects*; D010641:Phenotype; D011108:Polymers / Q000008:administration & dosage*; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D011108:Polymers
keywords: angiogenesis; cell-material interface; inflammation; mesenchymal stem cells; outside-in signaling; synthetic copolymers