title: Continuous cerebral hemodynamic measurement during deep hypothermic circulatory arrest.
abstract: While survival of children with complex congenital heart defects has improved in recent years, roughly half suffer neurological deficits suspected to be related to cerebral ischemia. Here we report the first demonstration of optical diffuse correlation spectroscopy (DCS) for continuous and non-invasive monitoring of cerebral microvascular blood flow during complex human neonatal or cardiac surgery. Comparison between DCS and Doppler ultrasound flow measurements during deep hypothermia, circulatory arrest, and rewarming were in good agreement. Looking forward, DCS instrumentation, alone and with NIRS, could provide access to flow and metabolic biomarkers needed by clinicians to adjust neuroprotective therapy during surgery.
authors.affiliation: Division of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA; Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: David R
authors.initials: DR
authors.lastname: Busch
authors.affiliation: Departments of Pediatrics and Cardiology, Baylor College of Medicine, Houston, TX, 77030 USA.
authors.forename: Craig G
authors.initials: CG
authors.lastname: Rusin
authors.affiliation: Department of Pediatric Cardiovascular Anesthesiology, Baylor College of Medicine, Houston, TX, 77030 USA.
authors.forename: Wanda
authors.initials: W
authors.lastname: Miller-Hance
authors.affiliation: Department of Pediatrics, Texas Children's Hospital, Houston, TX, 77030, USA.
authors.forename: Kathy
authors.initials: K
authors.lastname: Kibler
authors.affiliation: Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Anesthesiology and Critical Care, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Wesley B
authors.initials: WB
authors.lastname: Baker
authors.affiliation: Department of Surgery, Texas Children's Hospital, Houston, TX, 77030, USA.
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Heinle
authors.affiliation: Department of Surgery, Texas Children's Hospital, Houston, TX, 77030, USA.
authors.forename: Charles D
authors.initials: CD
authors.lastname: Fraser
authors.affiliation: Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Arjun G
authors.initials: AG
authors.lastname: Yodh
authors.affiliation: Division of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Licht
authors.affiliation: Department of Anesthesiology, Baylor College of Medicine, Houston, TX, 77030, USA.
authors.forename: Kenneth M
authors.initials: KM
authors.lastname: Brady
keywords: (170.3890) Medical optics instrumentation; (170.6935) Tissue characterization