title: Gene × Environment Interactions in Schizophrenia: Evidence from Genetic Mouse Models.
abstract: The study of gene × environment, as well as epistatic interactions in schizophrenia, has provided important insight into the complex etiopathologic basis of schizophrenia. It has also increased our understanding of the role of susceptibility genes in the disorder and is an important consideration as we seek to translate genetic advances into novel antipsychotic treatment targets. This review summarises data arising from research involving the modelling of gene × environment interactions in schizophrenia using preclinical genetic models. Evidence for synergistic effects on the expression of schizophrenia-relevant endophenotypes will be discussed. It is proposed that valid and multifactorial preclinical models are important tools for identifying critical areas, as well as underlying mechanisms, of convergence of genetic and environmental risk factors, and their interaction in schizophrenia.
authors.affiliation: School of Psychology, University of Nottingham, Nottingham NG7 2RD, UK.
authors.forename: Paula
authors.identifier: 0000-0001-6655-4784
authors.initials: P
authors.lastname: Moran
authors.affiliation: School of Medicine, University College Cork, Brookfield Health Sciences Complex, College Road, Cork, Ireland.
authors.forename: Jennifer
authors.identifier: 0000-0002-4305-2340
authors.initials: J
authors.lastname: Stokes
authors.affiliation: School of Medicine, University College Cork, Brookfield Health Sciences Complex, College Road, Cork, Ireland.
authors.forename: Julia
authors.initials: J
authors.lastname: Marr
authors.affiliation: School of Medicine, University College Cork, Brookfield Health Sciences Complex, College Road, Cork, Ireland.
authors.forename: Gavin
authors.initials: G
authors.lastname: Bock
authors.affiliation: School of Life Sciences, University of Glasgow, Room 220, Bower Building, Glasgow G12 8QQ, UK.
authors.forename: Lieve
authors.initials: L
authors.lastname: Desbonnet
authors.affiliation: Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland; Jiangsu Key Laboratory of Translational Research & Therapy for Neuropsychiatric Disorders and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
authors.forename: John
authors.initials: J
authors.lastname: Waddington
authors.affiliation: School of Medicine, University College Cork, Brookfield Health Sciences Complex, College Road, Cork, Ireland.
authors.forename: Colm
authors.identifier: 0000-0003-1365-1606
authors.initials: C
authors.lastname: O'Tuathaigh
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D006801:Humans; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics*