title: Preparation and properties of calcium citrate nanosheets for bone graft substitute.
abstract: A convenient and effective soft chemical method is presented for the synthesis of nano-scaled calcium citrate sheets. The preparation involved the precipitation of nano-calcium citrate by adding ethanol to reach the super saturation state of a solution containing calcium and citrate salts. The obtained nano-calcium citrate formed nanosheets, with the following dimensions: width of about 50∼500 nm and thickness of about 8∼30 nm. The results of the XRD analysis confirmed that the obtained sample is calcium citrate tetrahydrate, and the crystal degree decreased with an increase quantity of ethanol added. Animal experiments showed that the calcium citrate can promote the formation of new bone.
authors.affiliation: a College of Materials, Chemistry & Chemical Engineering, Chengdu University of Technology , Chengdu, Sichuan , P.R. China.
authors.forename: Junfeng
authors.initials: J
authors.lastname: Li
authors.affiliation: a College of Materials, Chemistry & Chemical Engineering, Chengdu University of Technology , Chengdu, Sichuan , P.R. China.
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Liu
authors.affiliation: a College of Materials, Chemistry & Chemical Engineering, Chengdu University of Technology , Chengdu, Sichuan , P.R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Gao
authors.affiliation: a College of Materials, Chemistry & Chemical Engineering, Chengdu University of Technology , Chengdu, Sichuan , P.R. China.
authors.forename: Liangzhao
authors.initials: L
authors.lastname: Zhong
authors.affiliation: b Research Center for Nano-Biomaterials , Analytical & Testing Center, Sichuan University , Chengdu, Sichuan , P.R. China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Zou
authors.affiliation: c College of Chemical Engineering, Sichuan University, Chengdu , Sichuan , P.R. China.
authors.forename: Xuefei
authors.initials: X
authors.lastname: Lai
mesh_terms: D000818:Animals; D018786:Bone Substitutes / Q000737:chemistry*; D019355:Calcium Citrate / Q000737:chemistry*; D006801:Humans; D023421:Models, Animal; D008962:Models, Theoretical; D049329:Nanostructures / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D018786:Bone Substitutes; D019355:Calcium Citrate
keywords: animal experiment; bone graft substitute; calcium citrate; nanosheet; soft chemistry synthesis