title: Nickel- and Photoredox-Catalyzed Cross-Coupling Reactions of Aryl Halides with 4-Alkyl-1,4-dihydropyridines as Formal Nucleophilic Alkylation Reagents.
abstract: A combination of nickel and photoredox catalysts promoted novel cross-coupling reactions of aryl halides with 4-alkyl-1,4-dihydropyridines. 4-Alkyl-1,4-dihydropyridines act as formal nucleophilic alkylation reagents through a photoredox-catalyzed carbon-carbon (C-C) bond-cleavage process. The present strategy provides an alternative to classical carbon-centered nucleophiles, such as organometallic reagents.
authors.affiliation: Department of Systems Innovation, School of Engineering, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
authors.forename: Kazunari
authors.initials: K
authors.lastname: Nakajima
authors.affiliation: Department of Systems Innovation, School of Engineering, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
authors.forename: Sunao
authors.initials: S
authors.lastname: Nojima
authors.affiliation: Department of Systems Innovation, School of Engineering, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan. ynishiba@sys.t.u-tokyo.ac.jp.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Nishibayashi
keywords: C−C cleavage; cross-coupling; dihydropyridines; nickel catalysts; photoredox catalysts