title: Association between the variability of the ABCA13 gene and the risk of major depressive disorder and schizophrenia in the Han Chinese population.
abstract: The ATP-binding cassette transporter superfamily is one of the largest membrane protein families, which is responsible for transportation of substances across the membranes by utilising energy. Some research has bridged the variations in ABCA13 with occurrence of psychiatric disorders. To investigate the overlapping risk conferred by ABCA13 for both major depressive disorder and schizophrenia, we analysed tag single nucleotide polymorphisms (tag SNPs).
  
  
  
  We used TaqMan®technology to genotype 1045 major depressive disorder patients, 1235 schizophrenia patients and 1235 healthy controls of Han Chinese origin.
  
  
  
  We found that rs7789493 (Pallele=7.23E-04, Pgenotype=.001) was associated with major depressive disorder, while rs17132388 (Pallele=1.63E-04, Pgenotype=7.50E-04) and rs6583476 (Pallele=5.50E-04, Pgenotype=.002) showed statistically significant association with schizophrenia.
  
  
  
  Our results indicate that the ABCA13 gene may contain overlapping common genetic risk factors for both major depressive disorder and schizophrenia in the Han Chinese population. The study on variants conferring overlapping risk for multiple psychiatric disorders could be tangible pathogenesis support in clinical or diagnostic references.
authors.affiliation: a Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Centre , Shanghai Jiao Tong University School of Medicine , Shanghai , P.R. China.|b Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Centre for Brain Science , Shanghai Jiao Tong University , Shanghai , P.R. China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Chen
authors.affiliation: b Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Centre for Brain Science , Shanghai Jiao Tong University , Shanghai , P.R. China.|c Department of Chemistry , University of Azad Jammu and Kashmir , Muzaffarabad , Pakistan.
authors.forename: Raja Amjad Waheed
authors.initials: RAW
authors.lastname: Khan
authors.affiliation: b Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Centre for Brain Science , Shanghai Jiao Tong University , Shanghai , P.R. China.
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.affiliation: d College of Life Science , Inner Mongolia University for Nationalities , Tongliao , Inner Mongolia , P.R.China.
authors.forename: Kuanjun
authors.initials: K
authors.lastname: He
authors.affiliation: b Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Centre for Brain Science , Shanghai Jiao Tong University , Shanghai , P.R. China.
authors.forename: Qingzhong
authors.initials: Q
authors.lastname: Wang
authors.affiliation: b Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Centre for Brain Science , Shanghai Jiao Tong University , Shanghai , P.R. China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Li
authors.affiliation: b Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Centre for Brain Science , Shanghai Jiao Tong University , Shanghai , P.R. China.
authors.forename: Wenjin
authors.initials: W
authors.lastname: Li
authors.affiliation: b Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Centre for Brain Science , Shanghai Jiao Tong University , Shanghai , P.R. China.
authors.forename: Zujia
authors.initials: Z
authors.lastname: Wen
authors.affiliation: b Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Centre for Brain Science , Shanghai Jiao Tong University , Shanghai , P.R. China.
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Song
authors.affiliation: b Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Centre for Brain Science , Shanghai Jiao Tong University , Shanghai , P.R. China.
authors.forename: Jiawei
authors.initials: J
authors.lastname: Shen
authors.affiliation: a Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Centre , Shanghai Jiao Tong University School of Medicine , Shanghai , P.R. China.
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Xu
authors.affiliation: b Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Centre for Brain Science , Shanghai Jiao Tong University , Shanghai , P.R. China.|e Shanghai Changning Mental Health Centre , Shanghai , P.R. China.|f Institute of Neuropsychiatric Science and Systems Biological Medicine , Shanghai Jiao Tong University , Shanghai , P.R. China.
authors.forename: Yongyong
authors.initials: Y
authors.lastname: Shi
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000328:Adult; D044466:Asian People / Q000235:genetics*; D002681:China; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*
chemical_list: C473800:ABCA13 protein, human; D018528:ATP-Binding Cassette Transporters
keywords: ABCA13 gene; Association; SNP; major depressive disorder; schizophrenia