title: miR-146a and miR-196a2 polymorphisms in ovarian cancer risk.
abstract: We investigated the relationship between miR-146a and miR-196a2 genetic polymorphisms and development of ovarian cancer in a Chinese population. A total of 134 patients and 227 control subjects were involved in our study between January 2012 and October 2014 from China-Japan Union Hospital of Jilin University. Genotyping of miR-146a and miR-196a2 was accomplished by polymerase chain reaction coupled with restriction fragment length polymorphism analysis. Unconditional multiple-logistic regression analysis indicated that the GG genotype of miR-146a was associated with an increased risk of ovarian cancer when compared to the CC genotype, and the adjusted OR (95%CI) was 3.73 (1.79-7.80). Moreover, the CG+GG genotype of miR-146a was associated with an increased risk of ovarian cancer compared with the CC genotype (OR = 1.68, 95%CI = 1.06-2.66), and the GG genotype had a higher risk of ovarian cancer than the CC+CG genotype (OR = 3.02, 95%CI = 1.55-5.98). In conclusion, our study suggests that the miR-146a polymorphism is associated with increased risk of ovarian cancer and could be used as a biomarker for ovarian cancer susceptibility.
authors.affiliation: Department of Obstetrics and Gynecology, China-Japan Union Hospital of Jilin University, Changchun, China.
authors.forename: X C
authors.initials: XC
authors.lastname: Sun
authors.affiliation: Department of Obstetrics and Gynecology, China-Japan Union Hospital of Jilin University, Changchun, China zhangaiccc@126.com.
authors.forename: A C
authors.initials: AC
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics and Gynecology, China-Japan Union Hospital of Jilin University, Changchun, China.
authors.forename: L L
authors.initials: LL
authors.lastname: Tong
authors.affiliation: Department of Obstetrics and Gynecology, China-Japan Union Hospital of Jilin University, Changchun, China.
authors.forename: K
authors.initials: K
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology, China-Japan Union Hospital of Jilin University, Changchun, China.
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology, China-Japan Union Hospital of Jilin University, Changchun, China.
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Sun
authors.affiliation: Department of Obstetrics and Gynecology, China-Japan Union Hospital of Jilin University, Changchun, China.
authors.forename: H Y
authors.initials: HY
authors.lastname: Zhang
mesh_terms: D044466:Asian People; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D016017:Odds Ratio; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: C542542:MIRN146 microRNA, human; C542543:MIRN196 microRNA, human; D035683:MicroRNAs