title: Efficacy and Safety of a Permethrin-Fipronil Spot-On Solution (Effitix®) in Dogs Naturally Infested by Ticks in Europe.
abstract: Effitix is a new broad spectrum product based on the combination of fipronil 6.1% and permethrin 54.5% in a solution for spot-on application. It has been shown to be safe and efficacious in dogs in controlling tick, flea, sandfly, and mosquito infestations in laboratory conditions. The aim of this controlled, randomised study was to assess its safety and efficacy against natural tick infestations in field conditions. One hundred eighty-two privately owned dogs were included in France and Germany: 123 dogs were treated on day 0 with the permethrin-fipronil combination (Effitix) and 59 with a permethrin-imidacloprid combination (Advantix®). Tick counts were conducted on days 0 (before treatment), 7, 14, 21, and 28. The percentages of efficacy on days 7, 14, 21, and 28 were, respectively, 91.2%, 97%, 98.3%, and 96.7% with Effitix and were 94.8%, 96.9%, 95.7%, and 94.6% with Advantix. Very few adverse events were reported. Most were not serious and/or not related to the treatment with pruritus being the most common. One administration of Effitix was highly effective and safe to treat and control tick infestations for four weeks in field conditions and had a similar efficacy as the permethrin-imidacloprid combination for all visits.
authors.affiliation: Virbac, 13ème rue, LID, 06511 Carros, France.
authors.forename: Christelle
authors.identifier: 0000-0001-6717-3289
authors.initials: C
authors.lastname: Navarro
authors.affiliation: Nadege Savelli EIRL, 2 rue de l'Église, 06270 Villeneuve-Loubet, France.
authors.forename: Nadège
authors.identifier: 0000-0001-8545-1086
authors.initials: N
authors.lastname: Reymond
authors.affiliation: Virbac, 13ème rue, LID, 06511 Carros, France.
authors.forename: Nolwenn
authors.identifier: 0000-0003-3899-5317
authors.initials: N
authors.lastname: Crastes
authors.affiliation: Virbac, 13ème rue, LID, 06511 Carros, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Bonneau
mesh_terms: D000287:Administration, Topical; D000818:Animals; D004283:Dog Diseases / Q000453:epidemiology* / Q000517:prevention & control*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D003875:Drug Eruptions / Q000453:epidemiology; D005060:Europe; D005260:Female; D005602:France / Q000453:epidemiology; D005858:Germany / Q000453:epidemiology; D007306:Insecticides / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D026023:Permethrin / Q000008:administration & dosage* / Q000009:adverse effects; D015995:Prevalence; D011720:Pyrazoles / Q000008:administration & dosage* / Q000009:adverse effects; D017282:Tick-Borne Diseases / Q000453:epidemiology / Q000517:prevention & control / Q000662:veterinary*; D016896:Treatment Outcome
chemical_list: D004338:Drug Combinations; D007306:Insecticides; D011720:Pyrazoles; D026023:Permethrin; C082360:fipronil