title: Significance of stem cell markerNanoggene in the diagnosis and prognosis of lung cancer.
abstract: The aim of the present study was to analyze the stem cell marker,Nanoggene, for the diagnosis and prognosis of lung cancer cases, and to study its application in the diagnosis of lung cancer. In total, 100 patients diagnosed with lung cancer between April, 2013 and May, 2015 were included in the present study. The patients were randomly divided into group A (lung cancer) and group B (squamous cell lung carcinoma). RT-PCR was used to detect the cancer and adjacent tissues, andNanoggene expression was detected in groups A and B in cells. The results showed that, analysis ofNanoggene expression in the two groups of patients varied to different degrees. There was no significant difference between the two groups with regard to age, gender, disease stage and lymph node metastasis.Nanoggene expression in patients with carcinoma were significantly higher than that in the adjacent tissues (p<0.05). By contrast, differentiated and well-differentiated carcinoma tissue showed a significantly higherNanoggene expression than poorly differentiated and undifferentiated carcinoma (p<0.05). The expression ofNanogin normal cells was significantly higher than that in normal lung tissues and benign lesions in lung cancer stem cells.Nanogwas highly expressed in CD44+cells, andNanogexpression in lung cancer stem cells was significantly higher (p<0.05). In conclusion, for groups A (lung cancer) and B (squamous cell lung carcinoma) theNanoggene expression was significantly higher. The data of the present study show that the patients with stage III and IV lung cancer had a higherNanoggene expression. In addition, there was a higher expression ofNanogin lung cancer patients. By contrast, a lower degree of cell differentiation was associated with strongNanoggene expression in lung cancer.
authors.affiliation: Department of Nuclear Medicine, Central Hospital of Xiangyang, Xiangyang, Hubei 441021, P.R. China.
authors.forename: Zeng
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Oncology, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Oncology, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China.
authors.forename: Honggang
authors.initials: H
authors.lastname: Kang
authors.affiliation: Department of Oncology, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China.
authors.forename: Guiming
authors.initials: G
authors.lastname: Sun
authors.affiliation: Department of Oncology, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China.
authors.forename: Baozhong
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Oncology, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China.
authors.forename: Yanwen
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Oncology, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China.
authors.forename: Mengxiang
authors.initials: M
authors.lastname: Yang
keywords: Nanog gene; lung cancer; stem cells