title: Silver-catalysed azide-alkyne cycloaddition (AgAAC): assessing the mechanism by density functional theory calculations.
abstract: 'Click reactions' are the copper catalysed dipolar cycloaddition reaction of azides and alkynes to incorporate nitrogens into a cyclic hydrocarbon scaffold forming a triazole ring. Owing to its efficiency and versatility, this reaction and the products, triazole-containing heterocycles, have immense importance in medicinal chemistry. Copper is the only known catalyst to carry out this reaction, the mechanism of which remains unclear. We report here that the 'click reactions' can also be catalysed by silver halides in non-aqueous medium. It constitutes an alternative to the well-known CuAAC click reaction. The yield of the reaction varies on the type of counter ion present in the silver salt. This reaction exhibits significant features, such as high regioselectivity, mild reaction conditions, easy availability of substrates and reasonably good yields. In this communication, the findings of a new catalyst along with the effect of solvent and counter ions will help to decipher the still obscure mechanism of this important reaction.
authors.affiliation: Organic and Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology; 4, Raja S.C. Mullick Road, Kolkata, India; Academy of Scientific and Innovative Research, CSIR-Indian Institute of Chemical Biology; 4, Raja S.C. Mullick Road, Kolkata, India.
authors.forename: Biswadip
authors.identifier: 0000-0001-9898-253X
authors.initials: B
authors.lastname: Banerji
authors.affiliation: Organic and Medicinal Chemistry Division , CSIR-Indian Institute of Chemical Biology; 4 , Raja S.C. Mullick Road, Kolkata , India.
authors.forename: K
authors.initials: K
authors.lastname: Chandrasekhar
authors.affiliation: Organic and Medicinal Chemistry Division , CSIR-Indian Institute of Chemical Biology; 4 , Raja S.C. Mullick Road, Kolkata , India.
authors.forename: Sunil Kumar
authors.initials: SK
authors.lastname: Killi
authors.affiliation: Organic and Medicinal Chemistry Division , CSIR-Indian Institute of Chemical Biology; 4 , Raja S.C. Mullick Road, Kolkata , India.
authors.forename: Sumit Kumar
authors.initials: SK
authors.lastname: Pramanik
authors.affiliation: Structural Biology and Bioinformatics Division , CSIR-Indian Institute of Chemical Biology; 4 , Raja S.C. Mullick Road, Kolkata , India.
authors.forename: Pal
authors.initials: P
authors.lastname: Uttam
authors.affiliation: Structural Biology and Bioinformatics Division , CSIR-Indian Institute of Chemical Biology; 4 , Raja S.C. Mullick Road, Kolkata , India.
authors.forename: Sudeshna
authors.initials: S
authors.lastname: Sen
authors.affiliation: Structural Biology and Bioinformatics Division , CSIR-Indian Institute of Chemical Biology; 4 , Raja S.C. Mullick Road, Kolkata , India.
authors.forename: Nakul Chandra
authors.initials: NC
authors.lastname: Maiti
keywords: Ag-catalyst; DFT; click reaction; cycloaddition; triazole