title: Lateralization of gene expression in the honeybee brain during olfactory learning.
abstract: In the last decade, it has been demonstrated that brain functional asymmetry occurs not only in vertebrates but also in invertebrates. However, the mechanisms underlying functional asymmetry remain unclear. In the present study, we trained honeybees of the same parentage and age, on the proboscis extension reflex (PER) paradigm with only one antenna in use. The comparisons of gene expression between the left and right hemispheres were carried out using high throughput sequencing. Our research revealed that gene expression in the honeybee brain is also asymmetric, with more genes having higher expression in the right hemisphere than the left hemisphere. Our studies show that during olfactory learning, the left hemisphere is more responsible for long term memory and the right hemisphere is more responsible for the learning and short term memory.
authors.affiliation: Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.|University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Honeybee Research Institute, Jiangxi Agricultural University, Nanchang, Jiangxi, 330045, China.
authors.forename: Zilong
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Honeybee Research Institute, Jiangxi Agricultural University, Nanchang, Jiangxi, 330045, China.
authors.forename: You
authors.initials: Y
authors.lastname: Li
authors.affiliation: Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.|University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Guifeng
authors.initials: G
authors.lastname: Wei
authors.affiliation: Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.|University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Yuan
authors.affiliation: Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.|University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Honeybee Research Institute, Jiangxi Agricultural University, Nanchang, Jiangxi, 330045, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Wang
authors.affiliation: Honeybee Research Institute, Jiangxi Agricultural University, Nanchang, Jiangxi, 330045, China.
authors.forename: Qiuhong
authors.initials: Q
authors.lastname: Qin
authors.affiliation: Honeybee Research Institute, Jiangxi Agricultural University, Nanchang, Jiangxi, 330045, China.
authors.forename: Zhijiang
authors.initials: Z
authors.lastname: Zeng
authors.affiliation: Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.|Honeybee Research Institute, Jiangxi Agricultural University, Nanchang, Jiangxi, 330045, China.|Research School of Biology, College of Medicine, Biology and Environment, The Australian National University, Australia.
authors.forename: Shaowu
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.|Research Network of Computational Biology, RNCB, Beijing, 100101, China.
authors.forename: Runsheng
authors.initials: R
authors.lastname: Chen
mesh_terms: D000818:Animals; D001516:Bees / Q000235:genetics / Q000502:physiology*; D001522:Behavior, Animal; D001921:Brain / Q000502:physiology*; D003214:Conditioning, Classical; D007839:Functional Laterality / Q000235:genetics*; D020869:Gene Expression Profiling / Q000379:methods*; D059014:High-Throughput Nucleotide Sequencing; D019476:Insect Proteins / Q000235:genetics*; D007858:Learning; D055696:Olfactory Perception / Q000235:genetics*; D017423:Sequence Analysis, RNA
chemical_list: D019476:Insect Proteins