title: Eyelid cleansing with ointment for obstructive meibomian gland dysfunction.
abstract: OBJECTIVE
  To investigate the efficacy of eyelid margin cleansing with ofloxacin ophthalmic ointment in obstructive meibomian gland dysfunction (MGD) patients.
  
  
  METHODS
  Thirty-one eyes of 31 patients diagnosed with obstructive MGD were enrolled. All subjects were instructed to rub the eyelid edge with ofloxacin eye ointment once daily prior to bathing. Lid margin abnormalities, meibum properties, and tear stability were observed before and 3 months after ointment treatment. A questionnaire relating to the severity of MGD symptoms was administered after the treatment.
  
  
  RESULTS
  Vascular engorgement, meibum, dandruff-like debris, and fluorescein staining scores significantly decreased after the treatment, whereas tear break-up time significantly increased (p < 0.05). Symptoms related to MGD improved after the treatment in 86.2 % of cases.
  
  
  CONCLUSIONS
  Cleansing treatment ofloxacin ophthalmic ointment at the eyelid margin may be effective for patients with obstructive MGD.
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Shinanomachi 35, Shinjuku-ku, Tokyo, 160-8582, Japan. fwiw1193@mb.infoweb.ne.jp.|Wada Eye Clinic, Chiba, Japan. fwiw1193@mb.infoweb.ne.jp.
authors.forename: Minako
authors.initials: M
authors.lastname: Kaido
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Shinanomachi 35, Shinjuku-ku, Tokyo, 160-8582, Japan.
authors.forename: Osama M A
authors.initials: OM
authors.lastname: Ibrahim
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Shinanomachi 35, Shinjuku-ku, Tokyo, 160-8582, Japan.
authors.forename: Motoko
authors.initials: M
authors.lastname: Kawashima
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Shinanomachi 35, Shinjuku-ku, Tokyo, 160-8582, Japan.|Ishida Eye Clinic, Shizuoka, Japan.
authors.forename: Reiko
authors.initials: R
authors.lastname: Ishida
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Shinanomachi 35, Shinjuku-ku, Tokyo, 160-8582, Japan.
authors.forename: Enrique A
authors.initials: EA
authors.lastname: Sato
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Shinanomachi 35, Shinjuku-ku, Tokyo, 160-8582, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tsubota
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D003251:Constriction, Pathologic; D003430:Cross-Sectional Studies; D005141:Eyelid Diseases / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008537:Meibomian Glands / Q000000981:diagnostic imaging* / Q000187:drug effects; D008875:Middle Aged; D015242:Ofloxacin / Q000008:administration & dosage*; D009824:Ointments
chemical_list: D000900:Anti-Bacterial Agents; D009824:Ointments; D015242:Ofloxacin
keywords: Dry eye; Lid hygiene; Meibomian gland dysfunction; Meibum; Tear stability