title: APPLICATION OF A NOVEL QUANTITATIVE TRACTOGRAPHY-BASED ANALYSIS OF DIFFUSION TENSOR IMAGING TO EXAMINE FIBER BUNDLE LENGTH IN HUMAN CEREBRAL WHITE MATTER.
abstract: This paper reviews basic methods and recent applications of length-based fiber bundle analysis of cerebral white matter using diffusion magnetic resonance imaging (dMRI). Diffusion weighted imaging (DWI) is a dMRI technique that uses the random motion of water to probe tissue microstructure in the brain. Diffusion tensor imaging (DTI) is an extension of DWI that measures the magnitude and direction of water diffusion in cerebral white matter, using either voxel-based scalar metrics or tractography-based analyses. More recently, quantitative tractography based on diffusion tensor imaging (qtDTI) technology has been developed to help quantify aggregate structural anatomical properties of white matter fiber bundles, including both scalar metrics of bundle diffusion and more complex morphometric properties, such as fiber bundle length (FBL). Unlike traditional scalar diffusion metrics, FBL reflects the direction and curvature of white matter pathways coursing through the brain and is sensitive to changes within the entire tractography model. In this paper, we discuss applications of this approach to date that have provided new insights into brain organization and function. We also discuss opportunities for improving the methodology through more complex anatomical models and potential areas of new application for qtDTI.
authors.affiliation: Department of Psychology, University of Missouri - Saint Louis, St. Louis, MO, USA.
authors.forename: Laurie M
authors.initials: LM
authors.lastname: Baker
authors.affiliation: Computer Science Department, Brown University, Providence, RI, USA.
authors.forename: Ryan P
authors.initials: RP
authors.lastname: Cabeen
authors.affiliation: Department of Psychology, University of Missouri - Saint Louis, St. Louis, MO, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Cooley
authors.affiliation: Computer Science Department, Brown University, Providence, RI, USA.
authors.forename: David H
authors.initials: DH
authors.lastname: Laidlaw
authors.affiliation: Department of Psychology, University of Missouri - Saint Louis, St. Louis, MO, USA; Missouri Institute of Mental Health, St. Louis, MO, USA.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Paul
keywords: Aging; Diffusion tensor imaging; Quantitative tractography; White matter