title: A biotin-guided formaldehyde sensor selectively detecting endogenous concentrations in cancerous cells and tissues.
abstract: A biotin appended formaldehyde sensor was found to specifically visualise both exogenous and endogenous levels of formaldehyde in biotin receptor positive cells over biotin negative cells by means of one- and two-photon excitation. The probe furthermore visualised endogenous levels of formaldehyde in tumour tissue slices up to 70 μm depth.
authors.affiliation: Department of Chemistry, Korea University, Seoul 136-701, Korea. jongskim@korea.ac.kr.
authors.forename: Yun Hak
authors.initials: YH
authors.lastname: Lee
authors.affiliation: Institute of Fluorescent Probes for Biological Imaging, School of Chemistry and Chemical Engineering, School of Biological Science and Technology, University of Jinan, Shandong 250022, P. R. China. weiyinglin2013@163.com.
authors.forename: Yonghe
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Chemistry, Korea University, Seoul 136-701, Korea. jongskim@korea.ac.kr.
authors.forename: Peter
authors.identifier: http://orcid.org/0000-0002-4673-2050
authors.initials: P
authors.lastname: Verwilst
authors.affiliation: Institute of Fluorescent Probes for Biological Imaging, School of Chemistry and Chemical Engineering, School of Biological Science and Technology, University of Jinan, Shandong 250022, P. R. China. weiyinglin2013@163.com.
authors.forename: Weiying
authors.initials: W
authors.lastname: Lin
authors.affiliation: Department of Chemistry, Korea University, Seoul 136-701, Korea. jongskim@korea.ac.kr.
authors.forename: Jong Seung
authors.initials: JS
authors.lastname: Kim
mesh_terms: D000818:Animals; D001710:Biotin / Q000737:chemistry*; D045744:Cell Line, Tumor; D005456:Fluorescent Dyes / Q000737:chemistry; D005557:Formaldehyde / Q000032:analysis* / Q000737:chemistry; D006801:Humans; D021621:Imaging, Three-Dimensional; D051379:Mice; D018613:Microscopy, Confocal; D041681:NIH 3T3 Cells; D009369:Neoplasms / Q000737:chemistry / Q000378:metabolism / Q000473:pathology*; D061848:Optical Imaging; D017785:Photons; D013050:Spectrometry, Fluorescence
chemical_list: D005456:Fluorescent Dyes; D005557:Formaldehyde; D001710:Biotin