title: Caging the uncageable: using metal complex release for photochemical control over irreversible inhibition.
abstract: Photochemical control over irreversible inhibition was shown using Ru(ii)-caged inhibitors of cathepsin L. Levels of control were dependent on where the Ru(ii) complex was attached to the organic inhibitor, reaching >10 : 1 with optimal placement. A new strategy for photoreleasing Ru(ii) fragments from inhibitor-enzyme conjugates is also reported.
authors.affiliation: Department of Chemistry, Wayne State University, Detroit, MI 48202, USA. jkodanko@chem.wayne.edu.
authors.forename: Matthew
authors.initials: M
authors.lastname: Huisman
authors.affiliation: Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA. turro1@osu.edu.
authors.forename: Jessica K
authors.initials: JK
authors.lastname: White
authors.affiliation: Department of Chemistry, Wayne State University, Detroit, MI 48202, USA. jkodanko@chem.wayne.edu.
authors.forename: Veronica G
authors.initials: VG
authors.lastname: Lewalski
authors.affiliation: Department of Pharmacology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA and Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA.
authors.forename: Izabela
authors.initials: I
authors.lastname: Podgorski
authors.affiliation: Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA. turro1@osu.edu.
authors.forename: Claudia
authors.initials: C
authors.lastname: Turro
authors.affiliation: Department of Chemistry, Wayne State University, Detroit, MI 48202, USA. jkodanko@chem.wayne.edu and Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA.
authors.forename: Jeremy J
authors.initials: JJ
authors.lastname: Kodanko