title: Successful renal retransplantation after graft loss from BK polyomavirus infection in a human immunodeficiency virus-positive patient.
abstract: We report the case of a human immunodeficiency virus-seropositive patient whose initial kidney transplant failed because of BK polyomavirus-induced nephropathy, and who underwent a second transplantation 3 years later. BK viruria was detected 1 day after transplantation. After 1 month, BK viremia developed along with a donor-specific antibody. After decreasing tacrolimus and mycophenolic acid and 2 courses of intravenous immunoglobulins, BK viremia and donor-specific antibody permanently disappeared, with stable renal function.
authors.affiliation: Department of Nephrology, CHU de Caen, Caen, France.|Medical School, Université Caen Normandie, Caen, France.
authors.forename: Aurore
authors.initials: A
authors.lastname: Barthélemy
authors.affiliation: Department of Nephrology, CHU de Caen, Caen, France.|Medical School, Université Caen Normandie, Caen, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Bouvier
authors.affiliation: Medical School, Université Caen Normandie, Caen, France.|Infectious Diseases Unit, CHU de Caen, Caen, France.
authors.forename: Renaud
authors.initials: R
authors.lastname: Verdon
authors.affiliation: Department of Nephrology, CHU de Caen, Caen, France.|Medical School, Université Caen Normandie, Caen, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Chatelet
authors.affiliation: Department of Nephrology, CHU de Caen, Caen, France.|Medical School, Université Caen Normandie, Caen, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Hurault de Ligny
mesh_terms: D064591:Allografts / Q000276:immunology / Q000473:pathology; D044966:Anti-Retroviral Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001739:BK Virus / Q000302:isolation & purification*; D001706:Biopsy; D006084:Graft Rejection / Q000209:etiology / Q000276:immunology / Q000473:pathology / Q000601:surgery*; D006679:HIV Seropositivity / Q000188:drug therapy*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use; D007155:Immunologic Factors / Q000008:administration & dosage / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D027601:Polyomavirus Infections / Q000097:blood / Q000150:complications* / Q000821:virology; D051437:Renal Insufficiency / Q000601:surgery; D012086:Reoperation; D014412:Tumor Virus Infections / Q000097:blood / Q000150:complications* / Q000821:virology; D014766:Viremia / Q000097:blood / Q000188:drug therapy / Q000821:virology
chemical_list: D044966:Anti-Retroviral Agents; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors; D007166:Immunosuppressive Agents
keywords: 
  HIV
  ; BK polyomavirus; BKV nephropathy; immunosuppression; kidney transplantation