title: Renal Side Effects of Non-Steroidal Anti-Inflammatory Drugs in Neonates.
abstract: Non-steroidal anti-inflammatory drugs like ibuprofen or indomethacin are commonly prescribed drugs to induce pharmacologic closure of a patent ductus arteriosus in preterm neonates. Based on a recently published Cochrane meta-analysis, both drugs are equally effective to induce closure. Drug choice can therefore be based on differences in side effects or pharmaco-economic arguments. The current review quantifies the negative impact of either ibuprofen or indomethacin on renal function, including diuresis, glomerular filtration rate and renal tubular function. Both ibuprofen and indomethacin have a quantifiable impact on renal function. However, compared to ibuprofen, the negative impact of indomethacin is more pronounced.
authors.affiliation: Neonatal Intensive Care Unit, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium. karel.allegaert@uz.kuleuven.ac.be.
authors.forename: Karel
authors.initials: K
authors.lastname: Allegaert
authors.affiliation: Center for Clinical Pharmacology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium. jan.dehoon@uz.kuleuven.ac.be.
authors.forename: Jan
authors.initials: J
authors.lastname: De Hoon
authors.affiliation: Neonatal Intensive Care Unit, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium. anne.debeer@uz.kuleuven.ac.be.
authors.forename: Anne
authors.initials: A
authors.lastname: Debeer
authors.affiliation: Department of Pediatric Cardiology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium. marc.gewillig@uz.kuleuven.ac.be.
authors.forename: Marc
authors.initials: M
authors.lastname: Gewillig
keywords: non-steroidal anti-inflammatory drugs; quantification; renal side effects