title: Time resolved diffuse optical spectroscopy with geometrically accurate models for bulk parameter recovery.
abstract: A novel straightforward, accessible and efficient approach is presented for performing hyperspectral time-domain diffuse optical spectroscopy to determine the optical properties of samples accurately using geometry specific models. To allow bulk parameter recovery from measured spectra, a set of libraries based on a numerical model of the domain being investigated is developed as opposed to the conventional approach of using an analytical semi-infinite slab approximation, which is known and shown to introduce boundary effects. Results demonstrate that the method improves the accuracy of derived spectrally varying optical properties over the use of the semi-infinite approximation.
authors.affiliation: PSIBS Doctoral Training Centre, University of Birmingham, Birmingham, UK; Department of Medical Physics and Biomedical Engineering, University College London, London, UK.
authors.forename: James A
authors.initials: JA
authors.lastname: Guggenheim
authors.affiliation: Center for Nano-Science and Technology @POLIMI, Istituto Italiano di Tecnologia, Milano, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Bargigia
authors.affiliation: Consiglio Nazionale delle Ricerche, Istituto di Fotonica e Nanotecnologie, Milano, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Farina
authors.affiliation: Consiglio Nazionale delle Ricerche, Istituto di Fotonica e Nanotecnologie, Milano, Italy; Politecnico di Milano, Dipartimento di Fisica, Milano, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Pifferi
authors.affiliation: PSIBS Doctoral Training Centre, University of Birmingham, Birmingham, UK; School of Computer Science, University of Birmingham, Birmingham, UK.
authors.forename: Hamid
authors.initials: H
authors.lastname: Dehghani
keywords: (170.3010) Image reconstruction techniques; (170.3660) Light propagation in tissues