title: Nanotubular self-organization of amide dendrons with focal β-sheet forming peptide units.
abstract: To develop rational design principles for a self-organized structure using dendron-peptide conjugates, a β-sheet forming short peptide (VVLL) was introduced to the focal point of a second-generation amide dendron (2G-VVLL) and its self-organization characteristics were investigated. 2G-VVLL self-organized into a nanotubular structure in the aqueous phase. The twisted β-sheet structure of the focal peptide unit was essential for the construction of the nanotubular structure. The design principle could be applied to another dendron-peptide conjugate (2G-AAVV). These findings are expected to assist in the construction of novel precisely controlled nanoarchitectures using amide dendrons with focal peptide units.
authors.affiliation: Department of Polymer Science and Engineering, Inha University, 100 Inharo, Nam-gu, Incheon, 22212, Korea. chk@inha.ac.kr.
authors.forename: Jeonghun
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Polymer Science and Engineering, Inha University, 100 Inharo, Nam-gu, Incheon, 22212, Korea. chk@inha.ac.kr.
authors.forename: Hyunil
authors.initials: H
authors.lastname: Jang
authors.affiliation: Department of Polymer Science and Engineering, Inha University, 100 Inharo, Nam-gu, Incheon, 22212, Korea. chk@inha.ac.kr.
authors.forename: Jonghwan
authors.initials: J
authors.lastname: Park
authors.affiliation: Department of Polymer Science and Engineering, Inha University, 100 Inharo, Nam-gu, Incheon, 22212, Korea. chk@inha.ac.kr.
authors.forename: Chulhee
authors.initials: C
authors.lastname: Kim
mesh_terms: D000577:Amides / Q000737:chemistry*; D050091:Dendrimers / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D000072757:Protein Conformation, beta-Strand
chemical_list: D000577:Amides; D050091:Dendrimers; D010455:Peptides