title: The Mind Bending Quest for Cognitive Enhancers.
abstract: Adequate cognitive functioning is essential for daily activities. When there is an insult to the brain, cognitive abilities can suffer, which, in turn, produce substantial medical and functional impairment. Advances in neurobiology, circuit neuroscience, and clinical assessment technology are converging in a manner that holds promise for the development of new pharmacological agents for cognitive enhancement in neuropsychiatric disease.
authors.affiliation: Neuroscience Research Unit, Pfizer Inc, Cambridge, Massachusetts, USA.
authors.forename: E
authors.initials: E
authors.lastname: Arce
authors.affiliation: Biogen, Cambridge, Massachusetts, USA.
authors.forename: M D
authors.initials: MD
authors.lastname: Ehlers
mesh_terms: D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D003071:Cognition / Q000187:drug effects*; D003072:Cognition Disorders / Q000188:drug therapy*; D015198:Designer Drugs / Q000494:pharmacology* / Q000627:therapeutic use*; D065127:Dopamine D2 Receptor Antagonists / Q000494:pharmacology; D006801:Humans; D018697:Nootropic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017447:Receptors, Dopamine D1 / Q000819:agonists
chemical_list: D002800:Cholinesterase Inhibitors; D015198:Designer Drugs; D065127:Dopamine D2 Receptor Antagonists; D018697:Nootropic Agents; D017447:Receptors, Dopamine D1