title: Secukinumab for Long-Term Treatment of Psoriatic Arthritis: A Two-Year Followup From a Phase III, Randomized, Double-Blind Placebo-Controlled Study.
abstract: To assess the 2-year efficacy and safety of the interleukin-17A inhibitor, secukinumab, in active psoriatic arthritis (PsA).
  
  
  
  In the FUTURE-1 study, 606 patients with active PsA were randomized to secukinumab 10 mg/kg intravenously at baseline, and at weeks 2 and 4, followed by 150 mg or 75 mg subcutaneously (SC) every 4 weeks from week 8, or matching placebo. Patients receiving placebo were re-randomized to secukinumab 150 mg or 75 mg SC from week 16 or week 24, depending upon clinical response. Treatment continued to week 104. Exploratory analysis of all primary and secondary end points, on an intent-to-treat basis, continued to week 104.
  
  
  
  A total of 476 patients (78.5%) completed 104 weeks of treatment. Secukinumab showed sustained efficacy across multiple domains of PsA through week 104, including signs and symptoms, disease activity, quality of life, physical function, skin symptoms, dactylitis, and enthesitis. American College of Rheumatology criteria for 20% improvement response rates were 66.8% with secukinumab 150 mg and 58.6% with secukinumab 75 mg at week 104; Psoriasis Area and Severity Index criteria for 75% improvement response rates were 74.6% and 63.0%, respectively (multiple imputed data). At week 104, 84.3% of patients in the secukinumab 150 mg group and 83.8% in the secukinumab 75 mg group showed no radiographic disease progression (observed data). No new or unexpected safety signals were reported during 2 years of treatment. Immunogenicity to secukinumab was low.
  
  
  
  Secukinumab provided sustained improvements in PsA at 2 years, with very little radiographic progression. Treatment was well tolerated over the long term.
authors.affiliation: University of California at San Diego, La Jolla, California.
authors.forename: Arthur
authors.initials: A
authors.lastname: Kavanaugh
authors.affiliation: Swedish Medical Center and University of Washington School of Medicine, Seattle.
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Mease
authors.affiliation: Dallas VA Medical Center and University of Texas Southwestern Medical Center, Dallas.
authors.forename: Andreas M
authors.initials: AM
authors.lastname: Reimold
authors.affiliation: Whipps Cross University Hospital, London, UK.
authors.forename: Hasan
authors.initials: H
authors.lastname: Tahir
authors.affiliation: Friedrich Alexander University, Erlangen-Nürnberg (FAU), Universitätsklinikum Erlangen, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Rech
authors.affiliation: Cabrini Monash University, Victoria, Australia.
authors.forename: Stephen
authors.initials: S
authors.lastname: Hall
authors.affiliation: CAPHRI/NUTRIM, Maastricht University Medical Centre, Maastricht, The Netherlands.
authors.forename: Piet
authors.initials: P
authors.lastname: Geusens
authors.affiliation: Novartis Pharma, East Hanover, New Jersey.
authors.forename: Zailong
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Novartis Pharma, East Hanover, New Jersey.
authors.forename: Luminita
authors.initials: L
authors.lastname: Pricop
authors.affiliation: Novartis Pharma, East Hanover, New Jersey.
authors.forename: Shephard
authors.initials: S
authors.lastname: Mpofu
mesh_terms: D000911:Antibodies, Monoclonal / Q000008:administration & dosage* / Q000009:adverse effects; D061067:Antibodies, Monoclonal, Humanized; D015535:Arthritis, Psoriatic / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage* / Q000009:adverse effects; D012074:Remission Induction; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D007155:Immunologic Factors; C555450:secukinumab