title: Application of Zebrafish Model to Environmental Toxicology.
abstract: Recently, a tropical freshwater fish, the zebrafish, has been generally used as a useful model organism in various fields of life science worldwide. The zebrafish model has also been applied to environmental toxicology; however, in Japan, it has not yet become widely used. In this review, we will introduce the biological and historical backgrounds of zebrafish as an animal model and their breeding. We then present the current status of toxicological experiments using zebrafish that were treated with some important environmental contaminants, including cadmium, organic mercury, 2,3,7,8-tetrachlorodibenzo-p-dioxin, and tributyltin. Finally, the future possible application of genetically modified zebrafish to the study of environmental toxicology is discussed.
authors.affiliation: Department of Hygiene and Public Health I, Tokyo Women's Medical University.
authors.forename: Yuta
authors.initials: Y
authors.lastname: Komoike
authors.forename: Masato
authors.initials: M
authors.lastname: Matsuoka
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D001947:Breeding; D019187:Cadmium Compounds / Q000633:toxicity; D054750:Ecotoxicology / Q000379:methods* / Q000639:trends; D004781:Environmental Exposure / Q000009:adverse effects*; D004785:Environmental Pollutants / Q000633:toxicity*; D007564:Japan; D017669:Mercury Compounds / Q000633:toxicity; D023421:Models, Animal; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity; D014220:Trialkyltin Compounds / Q000633:toxicity; D015027:Zebrafish
chemical_list: D019187:Cadmium Compounds; D004785:Environmental Pollutants; D017669:Mercury Compounds; D000072317:Polychlorinated Dibenzodioxins; D014220:Trialkyltin Compounds; C011559:tributyltin