title: Incidence and survival of sebaceous carcinoma in the United States.
abstract: BACKGROUND
  Information on risk factors, epidemiology, and clinical characteristics of sebaceous carcinoma (SC) is limited.
  
  
  OBJECTIVE
  We sought to analyze trends in SC in the United States from 2000 through 2012.
  
  
  METHODS
  We used data from the 18 registries of the Surveillance, Epidemiology, and End Results (SEER) Program from 2000 to 2012 to calculate the cause of death, relative frequencies/incidences, 5-/10-year Kaplan-Meier survival, hazard ratios, and incidence rates for SC. Each parameter was analyzed by age, location of occurrence (ocular/extraocular), race, sex, and SEER registry.
  
  
  RESULTS
  Overall incidence was 0.32 (male) and 0.16 (female) per 100,000 person-years. Incidence significantly increased, primarily because of an increase among men. Incidence among whites was almost 3 times the rate among non-whites. Male sex (P < .0001), black race (P = .01), and extraocular anatomic location (P < .0001) were associated with significantly higher all-cause mortality. However, overall case-specific mortality for SC decreased significantly.
  
  
  CONCLUSIONS
  Underregistration of patients in SEER registries, lack of verification of individual diagnoses, and low levels of staging data because of low stage-classification rate are limitations.
  
  
  CONCLUSIONS
  The overall incidence of SC is increasing significantly. Male sex, black race, and extraocular occurrences are associated with significantly greater mortality.
authors.affiliation: Department of Dermatology, Case Western Reserve University, Cleveland, Ohio; Department of Dermatology, University Hospitals Case Medical Center, Cleveland, Ohio. Electronic address: rxt177@case.edu.
authors.forename: Raghav
authors.initials: R
authors.lastname: Tripathi
authors.affiliation: Department of Family Medicine and Community Health, Case Western Reserve University, Cleveland, Ohio.
authors.forename: Zhengyi
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Family Medicine and Community Health, Case Western Reserve University, Cleveland, Ohio; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Dermatology, Case Western Reserve University, Cleveland, Ohio; Department of Dermatology, University Hospitals Case Medical Center, Cleveland, Ohio.
authors.forename: Jeremy S
authors.initials: JS
authors.lastname: Bordeaux
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data*; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000453:epidemiology* / Q000208:ethnology / Q000401:mortality; D002423:Cause of Death; D005134:Eye Neoplasms / Q000453:epidemiology* / Q000208:ethnology / Q000401:mortality; D005260:Female; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D018426:SEER Program; D012626:Sebaceous Gland Neoplasms / Q000453:epidemiology* / Q000208:ethnology / Q000401:mortality; D012737:Sex Factors; D015996:Survival Rate; D014481:United States / Q000453:epidemiology; D044465:White People / Q000706:statistics & numerical data*; D055815:Young Adult
keywords: Surveillance, Epidemiology, and End Results; cutaneous; epidemiology; extraocular; incidence; mortality; ocular; sebaceous carcinoma; skin cancer; survival