title: Inhibition of Apoptosis is a Potential Way to Improving Ischemic Brain Tolerance in Combined Exposure to Hypercapnia and Hypoxia.
abstract: We compared the intensity of apoptosis in the peri-infarction area of the brain after isolated and combined exposure to hypoxia and hypercapnia prior to focal ischemic stroke modeling. Hypoxia and hypercapnia reduced the number of TUNEL-positive cells in the peri-infarction area, and their combination was most effective in comparison with effects of isolated exposures. The maximum neuroprotective effect of combined exposure to hypoxia and hypercapnia in comparison with isolated exposures was determined by inhibition of apoptosis in the peri-infarction zone.
authors.affiliation: Altai State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia. pfiza_asmu@mail.ru.|Reserach Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia. pfiza_asmu@mail.ru.
authors.forename: P P
authors.initials: PP
authors.lastname: Tregub
authors.affiliation: V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation, Krasnoyarsk, Russia.
authors.forename: N A
authors.initials: NA
authors.lastname: Malinovskaya
authors.affiliation: Altai State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia.|Reserach Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
authors.forename: V P
authors.initials: VP
authors.lastname: Kulikov
authors.affiliation: V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation, Krasnoyarsk, Russia.
authors.forename: A B
authors.initials: AB
authors.lastname: Salmina
authors.affiliation: Altai State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia.
authors.forename: M E
authors.initials: ME
authors.lastname: Nagibaeva
authors.affiliation: Altai State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia.
authors.forename: A S
authors.initials: AS
authors.lastname: Zabrodina
authors.affiliation: V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation, Krasnoyarsk, Russia.
authors.forename: G E
authors.initials: GE
authors.lastname: Gertsog
authors.affiliation: V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation, Krasnoyarsk, Russia.
authors.forename: S K
authors.initials: SK
authors.lastname: Antonova
mesh_terms: D000818:Animals; D017209:Apoptosis; D002545:Brain Ischemia / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology; D006935:Hypercapnia / Q000473:pathology*; D002534:Hypoxia, Brain / Q000473:pathology*; D019194:Ischemic Preconditioning; D008297:Male; D065840:Protective Factors; D017208:Rats, Wistar
keywords: apoptosis; hypercapnia; hypoxia; neuroprotection; stroke