title: Rett Syndrome and the Ongoing Legacy of Close Clinical Observation.
abstract: This year marks the 50thanniversary of the publication of Andreas Rett's report on 22 girls who developed a peculiar and devastating neurological disorder that later came to bear his name. On this occasion, we reflect on the progress that has occurred in understanding Rett Syndrome, development of potential treatments, and the ramifications that Rett research has had on the fields of neurobiology and genetics.
authors.affiliation: Baylor College of Medicine, Howard Hughes Medical Institute, and Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA. Electronic address: hzoghbi@bcm.edu.
authors.forename: Huda Y
authors.initials: HY
authors.lastname: Zoghbi
mesh_terms: D002648:Child; D005260:Female; D049673:History, 20th Century; D006801:Humans; D051783:Methyl-CpG-Binding Protein 2 / Q000235:genetics; D009154:Mutation; D009446:Neurobiology / Q000639:trends; D010641:Phenotype; D015518:Rett Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics / Q000266:history
chemical_list: C497392:MECP2 protein, human; D051783:Methyl-CpG-Binding Protein 2