title: New lasiodiplodins from mangrove endophytic fungus Lasiodiplodia sp. 318.
abstract: Two new lasiodiplodins (1-2) together with three known analogues, were isolated from a mangrove endophytic fungus, Lasiodiplodia sp. 318#. Their structures were established by spectroscopic techniques (1D- and 2D-NMR, HR-ESI-MS, etc.), and electronic circular dichroism. Cytotoxic activities of compounds 1-5 were evaluated in vitro. Compound 4 was the most potent, with IC50values of 5.29 μM against MMQ, 13.05 μM against GH3. Preliminary structural-activity analysis indicated that the functional group (resorcinol-3-OH) contributed greatly to the binding of Lasiodiplodins to the cytotoxic activities.
authors.affiliation: a School of Marine Sciences , Sun Yat-sen University , Guangzhou , China.|b South China Sea Resource Exploitation and Protection Collaborative Innovation Center , Sun Yat-sen University , Guangzhou , China.
authors.forename: Jiguo
authors.initials: J
authors.lastname: Huang
authors.affiliation: a School of Marine Sciences , Sun Yat-sen University , Guangzhou , China.
authors.forename: Jiayi
authors.initials: J
authors.lastname: Xu
authors.affiliation: d Department of Histology and Embryology, Zhongshan School of Medical , Sun Yat-sen University , Guangzhou , China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.affiliation: a School of Marine Sciences , Sun Yat-sen University , Guangzhou , China.
authors.forename: Dilfaraz
authors.initials: D
authors.lastname: Khan
authors.affiliation: a School of Marine Sciences , Sun Yat-sen University , Guangzhou , China.
authors.forename: Shah Iram
authors.initials: SI
authors.lastname: Niaz
authors.affiliation: d Department of Histology and Embryology, Zhongshan School of Medical , Sun Yat-sen University , Guangzhou , China.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: c School of Chemistry and Chemical Engineering , Sun Yat-sen University , Guangzhou , China.
authors.forename: Yongcheng
authors.initials: Y
authors.lastname: Lin
authors.affiliation: a School of Marine Sciences , Sun Yat-sen University , Guangzhou , China.|b South China Sea Resource Exploitation and Protection Collaborative Innovation Center , Sun Yat-sen University , Guangzhou , China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: a School of Marine Sciences , Sun Yat-sen University , Guangzhou , China.|b South China Sea Resource Exploitation and Protection Collaborative Innovation Center , Sun Yat-sen University , Guangzhou , China.
authors.forename: Lan
authors.initials: L
authors.lastname: Liu
mesh_terms: D001203:Ascomycota / Q000737:chemistry*; D016923:Cell Death / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D003904:Mitosporic Fungi / Q000737:chemistry; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D015025:Zearalenone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C417552:lasiodiplodin; D015025:Zearalenone
keywords: Lasiodiplodia; Mangrove endophytic fungus; lasiodiplodins