title: Effects of Purge-Flow Rate on Microbubble Capture in Radial Arterial-Line Filters.
abstract: The process of microbubble filtration from blood is complex and highly dependent on the forces of flow and buoyancy. To protect the patient from air emboli, arterial-line filters commonly use a micropore screen, a large volume housing with purpose-built shape, and a purge port to trap, separate, and remove circulating microbubbles. Although it has been proposed that an insufficient buoyancy force renders the purge port ineffective at removing microbubbles smaller than 500 μm, this research attempts to investigate the purge flow of an arterial-line filter to better understand the microbubble removal function in a typical radial filter design. As its primary objective, the study aims to determine the effect of purge-flow rate on bubble capture using air bolus injections from a syringe pump with 22-gauge needle and Doppler ultrasound bubble detection. The measureable bubble size generated in the test circuit ranged between 30 and 500 μm, while purge flow was varied between .1 and .5 L/min for testing. Statistical analysis of the test data was handled using a repeated measures design with significance set atp< .05 level. Outcomes demonstrated that higher purge flows yielded higher bubble counts, but the effect of purge-flow rate on bubble capture decreased as bubble size increased. Results also showed that purge flow from the test filter was capable of capturing all bubble sizes being generated over the entire flow range tested, and confirms utility of the purge port in removing microbubbles smaller than 500 μm. By analyzing bubble counts in the purge flow of a typical radial-filter design, this study demonstrates that currently available micropore filter technology is capable of removing the size range of bubbles that commonly pass through modern pump-oxygenator systems and should continue to be considered during extracorporeal circulation as a measure to improve patient safety.
authors.affiliation: Department of Cardiac Surgery, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada.
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Herbst
mesh_terms: D001774:Blood Chemical Analysis / Q000295:instrumentation; D001781:Blood Component Removal / Q000295:instrumentation*; D001783:Blood Flow Velocity / Q000502:physiology*; D002315:Cardiopulmonary Bypass / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005740:Gases / Q000737:chemistry / Q000302:isolation & purification*; D006440:Hemofiltration / Q000295:instrumentation / Q000379:methods; D006801:Humans; D045423:Microbubbles; D008851:Micropore Filters; D017534:Radial Artery / Q000502:physiology*; D014462:Ultrafiltration / Q000295:instrumentation
chemical_list: D005740:Gases
keywords: Doppler ultrasound; arterial-line; bubble counter; cardiopulmonary bypass equipment; filtration; microbubble; micropore; patient safety