title: AXIN Shapes Tankyrase ARChitecture.
abstract: The poly(ADP-ribose)polymerase (PARP) Tankyrase uses ankyrin repeat modules to capture substrates via Tankyrase-binding peptide motifs. In this issue of Structure, Eisemann et al. (2016) describe how the signaling protein AXIN can access and conformationally adapt the multivalent ankyrin repeat region of Tankyrase and discuss potential implications for enzymatic substrate modification.
authors.affiliation: Divisions of Structural Biology and Cancer Biology, The Institute of Cancer Research (ICR), London SW7 3RP, UK. Electronic address: sebastian.guettler@icr.ac.uk.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Guettler
mesh_terms: D000246:Adenosine Diphosphate Ribose; D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D017089:Ankyrin Repeat; D017487:Ankyrins; D060466:Axin Protein; D011065:Poly(ADP-ribose) Polymerases / Q000737:chemistry; D038501:Tankyrases / Q000737:chemistry*; D016615:Telomere
chemical_list: D017487:Ankyrins; D060466:Axin Protein; D000246:Adenosine Diphosphate Ribose; D011065:Poly(ADP-ribose) Polymerases; D038501:Tankyrases