title: History of His bundle pacing.
abstract: Chronic right ventricular (RV) pacing has been shown over the years to exert detrimental physiological changes including increased risk for heart failure and atrial fibrillation. His bundle pacing offers the promise of physiological activation of the ventricular tissue, with the potential for reducing the detrimental effects of RV pacing. We describe His bundle pacing in a historical context and briefly highlight several clinical trials that have helped shape the landscape of permanent His bundle pacing.
authors.affiliation: Indiana University School of Medicine, Indianapolis, IN. Electronic address: gdandamu@iu.edu.
authors.forename: Gopi
authors.initials: G
authors.lastname: Dandamudi
authors.affiliation: Geisinger Heart Institute, Wilkes-Barre, PA.
authors.forename: Pugazhendhi
authors.initials: P
authors.lastname: Vijayaraman
mesh_terms: D001281:Atrial Fibrillation / Q000209:etiology* / Q000517:prevention & control; D002036:Bundle of His / Q000503:physiopathology*; D002037:Bundle-Branch Block / Q000503:physiopathology* / Q000517:prevention & control*; D002304:Cardiac Pacing, Artificial / Q000009:adverse effects* / Q000379:methods*; D019317:Evidence-Based Medicine; D006333:Heart Failure / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D016896:Treatment Outcome
keywords: Chronic RV pacing; Heart failure; His bundle pacing; QRS complex