title: Nickel allergy: blood and periodontal evaluation after orthodontic treatment.
abstract: The aim of this study was to assess periodontal status and blood parameters in orthodontic patients with nickel allergy one month after removal of brackets. Ninety-six randomly selected patients were initially evaluated. Allergy to nickel was diagnosed using a patch test. After determining the prevalence of subjects allergic to nickel, two groups were formed: 16 allergic (experimental) and 16 non-allergic (control) patients. Their periodontal status was determined regularly by a single, blinded, duly calibrated examiner using the Löe Index (GI) and their blood was tested (complete blood test, including nickel and IgE levels) after nine months of orthodontic treatment and again one month after removing the orthodontic appliances. Statistical analyses included paired and non-paired t-tests, Mann-Whitney, Wilcoxon, McNemar and linear trend chi-square tests (p≤0.05). Comparison of the values recorded during orthodontic treatment and one month after removing the appliances showed that in the allergic group there was significant increase in eosinophils (p=0.046), basophils (p=0.001) and monocytes (p=0.002), and decrease in number of bands (p=0.000), while in the control group, there was increase in lymphocytes (p=0.039) and decrease in segmented neutrophils (p=0.030) and IgE levels (p=0.001). In both groups, plasma nickel levels increased (p=0.010; p=0.039) and GI scores decreased. One month after removing the brackets, blood and periodontal parameters from patients with and without nickel allergy were similar.
authors.affiliation: Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Minas Gerais - UFMG, Belo Horizonte, MG, Brazil. camilapazzini@hotmail.com.
authors.forename: Camila A
authors.initials: CA
authors.lastname: Pazzini
authors.affiliation: Department of Health Sciences, Federal University of Lavras - UFLA, Lavras, MG, Brazil.
authors.forename: Luciano J
authors.initials: LJ
authors.lastname: Pereira
authors.affiliation: Department of Immunology, Federal University of Lavras - UFLA, Lavras, MG, Brazil.
authors.forename: Ana P
authors.initials: AP
authors.lastname: Peconick
authors.affiliation: Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Vale do Jequitinhonha e Mucuri - UFVJM, Diamantina, MG, Brazil.
authors.forename: Leandro S
authors.initials: LS
authors.lastname: Marques
authors.affiliation: Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Minas Gerais - UFMG, Belo Horizonte, MG, Brazil.
authors.forename: Saul M
authors.initials: SM
authors.lastname: Paiva
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D020878:Device Removal; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000097:blood* / Q000209:etiology* / Q000628:therapy; D008297:Male; D009532:Nickel / Q000009:adverse effects*; D016382:Orthodontic Appliance Design; D009967:Orthodontic Appliances; D010512:Periodontal Index; D055815:Young Adult
chemical_list: D009532:Nickel
keywords: Allergy and immunology; blood; hypersensitivity; nickel; orthodontics