title: Cajal bodies and their role in plant stress and disease responses.
abstract: Cajal bodies (CBs) are distinct sub-nuclear structures that are present in eukaryotic living cells and are often associated with the nucleolus. CBs play important roles in RNA metabolism and formation of RNPs involved in transcription, splicing, ribosome biogenesis, and telomere maintenance. Besides these primary roles, CBs appear to be involved in additional functions that may not be directly related to RNA metabolism and RNP biogenesis. In this review, we assess possible roles of plant CBs in RNA regulatory pathways such as nonsense-mediated mRNA decay and RNA silencing. We also summarize recent progress and discuss new non-canonical functions of plant CBs in responses to stress and disease. It is hypothesized that CBs can regulate these responses via their interaction with poly(ADP ribose)polymerase (PARP), which is known to play an important role in various physiological processes including responses to biotic and abiotic stresses. It is suggested that CBs and their components modify PARP activities and functions.
authors.affiliation: a Cell and Molecular Sciences , James Hutton Institute , Invergowrie, Dundee , UK.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Love
authors.affiliation: b State Key Laboratory Breeding Base for Sustainable Pest and Disease Control, Key Laboratory of Biotechnology in Plant Protection of MOA and Zhejiang Province , Institute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences , Hangzhou , China.
authors.forename: Chulang
authors.initials: C
authors.lastname: Yu
authors.affiliation: a Cell and Molecular Sciences , James Hutton Institute , Invergowrie, Dundee , UK.
authors.forename: Natalia V
authors.initials: NV
authors.lastname: Petukhova
authors.affiliation: c A.N. Belozersky Institute of Physico-Chemical Biology , Lomonosov Moscow State University , Leninskie Gory, Moscow , Russia.
authors.forename: Natalia O
authors.initials: NO
authors.lastname: Kalinina
authors.affiliation: b State Key Laboratory Breeding Base for Sustainable Pest and Disease Control, Key Laboratory of Biotechnology in Plant Protection of MOA and Zhejiang Province , Institute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences , Hangzhou , China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Chen
authors.affiliation: a Cell and Molecular Sciences , James Hutton Institute , Invergowrie, Dundee , UK.|b State Key Laboratory Breeding Base for Sustainable Pest and Disease Control, Key Laboratory of Biotechnology in Plant Protection of MOA and Zhejiang Province , Institute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences , Hangzhou , China.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Taliansky
mesh_terms: D020541:Coiled Bodies / Q000235:genetics / Q000378:metabolism*; D018506:Gene Expression Regulation, Plant; D054884:Host-Pathogen Interactions / Q000235:genetics; D009687:Nuclear Proteins / Q000378:metabolism; D010935:Plant Diseases / Q000235:genetics* / Q000821:virology; D018521:Plant Physiological Phenomena; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D012342:RNA, Small Nuclear / Q000235:genetics / Q000378:metabolism; D017411:Ribonucleoproteins, Small Nuclear / Q000378:metabolism; D013312:Stress, Physiological / Q000235:genetics
chemical_list: D009687:Nuclear Proteins; D012342:RNA, Small Nuclear; D017411:Ribonucleoproteins, Small Nuclear; C068921:p80-coilin; D011065:Poly(ADP-ribose) Polymerases
keywords: Abiotic stress; Cajal bodies; PARP; plant viruses; plants