title: Stem cells and colorectal carcinogenesis.
abstract: Colorectal cancer represents an important cause of mortality and morbidity. Unfortunately, the physiopathology is still under study. There are theories about carcinogenesis and it is known that not only a single factor is responsible for the development of a tumor, but several conditions. Stem cells are a promising target for the treatment of colorectal cancer, along with the environment that has an important role. It has been postulated that mutations within the adult colonic stem cells may induce neoplastic changes. This theory is based on the observation that within a colon cancer, less than 1% of the neoplastic cells have the ability to regenerate the tumor and therefore they are responsible for recurrence. It is important to know that a new way of treatment needs to be found, since these cells are resistant to chemotherapy and radiotherapy.
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest; Internal Medicine Department, "Dr. Ion Cantacuzino" Clinical Hospital, Bucharest, Romania.
authors.forename: M
authors.initials: M
authors.lastname: Stoian
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest; Internal Medicine Department, "Dr. Ion Cantacuzino" Clinical Hospital, Bucharest, Romania.
authors.forename: V
authors.initials: V
authors.lastname: Stoica
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania "Nicolae Paulescu" National Institute of Diabetes, Nutrition and Metabolic Diseases, Bucharest, Romania.
authors.forename: G
authors.initials: G
authors.lastname: Radulian
mesh_terms: D063646:Carcinogenesis; D015179:Colorectal Neoplasms / Q000235:genetics / Q000473:pathology*; D006801:Humans; D009154:Mutation; D014411:Neoplastic Stem Cells / Q000473:pathology*
keywords: colorectal cancer; stem cells; tumor markers