title: Neuronal SOCE: Myth or Reality?
abstract: Store-operated Ca2+entry (SOCE) is the primary Ca2+influx pathway in non-excitable cells. Long thought to be absent in nerve cells, neuronal SOCE is gaining popularity. We argue here that the evidence for SOCE in neurons remains contentious, mostly because SOCE imaging assays are inadequate in these cells.
authors.affiliation: Duke-National University of Singapore Medical School, Program in Neuroscience and Behavioral Disorders, Singapore.
authors.forename: Bo
authors.initials: B
authors.lastname: Lu
authors.affiliation: Duke-National University of Singapore Medical School, Program in Neuroscience and Behavioral Disorders, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: marc.fivaz@duke-nus.edu.sg.
authors.forename: Marc
authors.initials: M
authors.lastname: Fivaz
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D020013:Calcium Signaling; D006801:Humans; D008954:Models, Biological; D009474:Neurons / Q000378:metabolism*
chemical_list: D015220:Calcium Channels; D002118:Calcium
keywords: SOCE; STIM; calcium imaging; endoplasmic reticulum; neuron