title: Autologous hematopoietic cell transplantation for acute promyelocytic leukemia in second complete remission: outcomes before and after the introduction of arsenic trioxide.
abstract: We conducted a retrospective registry-based study involving 198 patients with acute promyelocytic leukemia (APL) who underwent autologous hematopoietic cell transplantation (HCT) during second complete remission (CR2) from 1995 to 2012. Arsenic trioxide (ATO) became commercially available in Japan in December 2004, and a substantial increase in the annual numbers of transplantations has occurred since 2005. Patients transplanted after 2006 had significantly better relapse-free and overall survival than those transplanted before 2004 (p = .028 and p = .027, respectively). There was a significant difference in cumulative incidence of relapse in favor of those transplanted after 2006 (p = .008), whereas non-relapse mortality did not differ between the two groups (p = .683). Our findings suggest that the introduction of ATO may have reduced post-transplantation relapse without increasing non-relapse mortality, resulting in significant improvements in overall outcomes for relapsed APL patients undergoing autologous HCT during CR2.
authors.affiliation: a Fujita Health University School of Medicine , Toyoake , Japan.
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Yanada
authors.affiliation: b Jikei University School of Medicine , Tokyo , Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Yano
authors.affiliation: c Kanagawa Cancer Center , Yokohama , Japan.
authors.forename: Heiwa
authors.initials: H
authors.lastname: Kanamori
authors.affiliation: d Tokyo Medical University , Tokyo , Japan.
authors.forename: Moritaka
authors.initials: M
authors.lastname: Gotoh
authors.affiliation: a Fujita Health University School of Medicine , Toyoake , Japan.
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Emi
authors.affiliation: e Tokyo Metropolitan Komagome Hospital , Tokyo , Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Watakabe
authors.affiliation: f Graduate School of Medicine, The University of Tokyo , Tokyo , Japan.
authors.forename: Mineo
authors.initials: M
authors.lastname: Kurokawa
authors.affiliation: g Wakayama Medical University , Wakayama , Japan.
authors.forename: Akinori
authors.initials: A
authors.lastname: Nishikawa
authors.affiliation: h Keio University School of Medicine , Tokyo , Japan.
authors.forename: Takehiko
authors.initials: T
authors.lastname: Mori
authors.affiliation: i Yokohama City University Graduate School of Medicine , Yokohama , Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Tomita
authors.affiliation: j Nagoya University Graduate School of Medicine , Nagoya , Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Murata
authors.affiliation: k Kobe Medical Center Central Hospital/Foundation of Biomedical Research and Innovation , Kobe , Japan.
authors.forename: Hisako
authors.initials: H
authors.lastname: Hashimoto
authors.affiliation: l Hamanomachi Hospital , Fukuoka , Japan.
authors.forename: Hideho
authors.initials: H
authors.lastname: Henzan
authors.affiliation: m Saitama Medical Center, Jichi Medical University , Saitama , Japan.
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Kanda
authors.affiliation: n Anjo Kosei Hospital , Anjo , Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Sawa
authors.affiliation: o JA Aichi Konan Kosei Hospital , Konan , Japan.
authors.forename: Akio
authors.initials: A
authors.lastname: Kohno
authors.affiliation: j Nagoya University Graduate School of Medicine , Nagoya , Japan.|p Japanese Data Center for Hematopoietic Cell Transplantation , Nagoya , Japan.
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Atsuta
authors.affiliation: q Hiroshima University Hospital , Hiroshima , Japan.
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Ichinohe
authors.affiliation: r Aichi Medical University School of Medicine , Nagakute , Japan.
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Takami
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007564:Japan; D015473:Leukemia, Promyelocytic, Acute / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010087:Oxides / Q000627:therapeutic use; D012008:Recurrence; D012074:Remission Induction; D019172:Transplantation Conditioning; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D001152:Arsenicals; D010087:Oxides; D000077237:Arsenic Trioxide
keywords: Acute promyelocytic leukemia; arsenic trioxide; autologous hematopoietic cell transplantation; second complete remission