title: Base-mediated one-pot synthesis of 1,2,4-oxadiazoles from nitriles, aldehydes and hydroxylamine hydrochloride without addition of extra oxidant.
abstract: A simple base-mediated one-pot synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from nitriles, aldehydes and hydroxylamine hydrochloride has been developed, in which the aldehydes act as both substrates and oxidants. The reactions include three sequential procedures: base-promoted intermolecular addition of hydroxylamine to nitrile to lead to amidoxime, treatment of the amidoxime with an aldehyde to form 4,5-dihydro-1,2,4-oxadiazole, and oxidization of the 4,5-dihydro-1,2,4-oxadiazole by using another aldehyde to afford 1,2,4-oxadiazole. This method represents a direct and simple protocol for the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles.
authors.affiliation: Institute of Fine Chemistry and Engineering, Henan Engineering Laboratory of Flame-retardant and Functional Materials, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, P. R. China. xuhao@henu.edu.cn 18937822307@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Institute of Fine Chemistry and Engineering, Henan Engineering Laboratory of Flame-retardant and Functional Materials, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, P. R. China. xuhao@henu.edu.cn 18937822307@163.com.
authors.forename: Hao
authors.initials: H
authors.lastname: Xu
authors.affiliation: Institute of Fine Chemistry and Engineering, Henan Engineering Laboratory of Flame-retardant and Functional Materials, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, P. R. China. xuhao@henu.edu.cn 18937822307@163.com.
authors.forename: Yuanqing
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Institute of Fine Chemistry and Engineering, Henan Engineering Laboratory of Flame-retardant and Functional Materials, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, P. R. China. xuhao@henu.edu.cn 18937822307@163.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Ding
authors.affiliation: Institute of Fine Chemistry and Engineering, Henan Engineering Laboratory of Flame-retardant and Functional Materials, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, P. R. China. xuhao@henu.edu.cn 18937822307@163.com.
authors.forename: Wenkai
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Institute of Fine Chemistry and Engineering, Henan Engineering Laboratory of Flame-retardant and Functional Materials, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, P. R. China. xuhao@henu.edu.cn 18937822307@163.com.
authors.forename: Yanrong
authors.initials: Y
authors.lastname: Ren
authors.affiliation: Institute of Fine Chemistry and Engineering, Henan Engineering Laboratory of Flame-retardant and Functional Materials, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, P. R. China. xuhao@henu.edu.cn 18937822307@163.com.
authors.forename: Haibo
authors.initials: H
authors.lastname: Chang