title: [Subjective Cognitive Decline and Development of Dementia - Results from the Leipzig Longitudinal Study of the Aged (LEILA75+)].
abstract: Objective:Subjective cognitive decline is controversially discussed as early notable sign of future dementia in the literature. Therefore, we aimed to investigate whether SCD predicts dementia in a sample of cognitively unimpaired older individuals (75+).Methods:595 cognitively unimpaired individuals who participated in the Leipzig Longitudinal Study of the Aged (LEILA75+) were regularly interviewed and cognitively tested over 8 years. Cox regression analyses were used to determine the association of SCD and development of dementia.Results:SCD at baseline was not associated with an increased dementia risk when adjusted for covariates. By contrast, subtle deficits on cognitive testing, though within a normal range, indicated higher dementia risk.Conclusion:SCD is not a clear indicator for the development of dementia. However, individuals who exhibit subtle deficits on cognitive tests, though within the normal range, should be monitored closely as they might be at increased risk for dementia.
authors.affiliation: Institut für Sozialmedizin, Arbeitsmedizin und Public Health (ISAP), Medizinische Fakultät, Universität Leipzig.
authors.forename: Susanne
authors.initials: S
authors.lastname: Röhr
authors.affiliation: Institut für Sozialmedizin, Arbeitsmedizin und Public Health (ISAP), Medizinische Fakultät, Universität Leipzig.
authors.forename: Tobias
authors.initials: T
authors.lastname: Luck
authors.affiliation: Max Planck Institut für Kognitions- und Neurowissenschaften, Leipzig.
authors.forename: Arno
authors.initials: A
authors.lastname: Villringer
authors.affiliation: Zentrum für Public Mental Health, Gösing a. W., Österreich.
authors.forename: Matthias C
authors.initials: MC
authors.lastname: Angermeyer
authors.affiliation: Institut für Sozialmedizin, Arbeitsmedizin und Public Health (ISAP), Medizinische Fakultät, Universität Leipzig.
authors.forename: Steffi G
authors.initials: SG
authors.lastname: Riedel-Heller
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000523:psychology*; D060825:Cognitive Dysfunction / Q000175:diagnosis / Q000523:psychology*; D003863:Depression / Q000175:diagnosis / Q000523:psychology; D059026:Diagnostic Self Evaluation; D018450:Disease Progression; D004522:Educational Status; D005260:Female; D005858:Germany; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009483:Neuropsychological Tests; D016016:Proportional Hazards Models; D011446:Prospective Studies