title: Mechanistic analysis of aliphatic β-lactones in Vibrio harveyi reveals a quorum sensing independent mode of action.
abstract: N-Acylhomoserine lactones are autoinducers of quorum sensing (QS) in Gram-negative bacteria. We exploit here the role of structurally related β-lactones in the inhibition of Vibrio harveyi bioluminescence and identify a derivative with nanomolar potency. Surprisingly, QS was not affected and combined proteomic/biochemical studies revealed insights into the cellular mode of action.
authors.affiliation: Department of Chemistry, Center for Integrated Protein Science Munich (CIPSM), Technische Universität München, Garching, Germany. stephan.sieber@tum.de.
authors.forename: Weining
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Center for Integrated Protein Science Munich (CIPSM) at the Department of Biology I, Ludwig-Maximilians-Universität München, Germany.
authors.forename: Nicola
authors.initials: N
authors.lastname: Lorenz
authors.affiliation: Center for Integrated Protein Science Munich (CIPSM) at the Department of Biology I, Ludwig-Maximilians-Universität München, Germany.
authors.forename: Kirsten
authors.initials: K
authors.lastname: Jung
authors.affiliation: Department of Chemistry, Center for Integrated Protein Science Munich (CIPSM), Technische Universität München, Garching, Germany. stephan.sieber@tum.de.
authors.forename: Stephan A
authors.initials: SA
authors.lastname: Sieber