title: Safety Evaluation and Imaging Properties of Gadolinium-Based Nanoparticles in nonhuman primates.
abstract: In this article, we report the safety evaluation of gadolinium-based nanoparticles in nonhuman primates (NHP) in the context of magnetic resonance imaging (MRI) studies in atherosclerosis bearing animals and healthy controls. In healthy NHP, the pharmacokinetics and toxicity profiles demonstrated the absence of dose, time, and sex-effects, as well as a suitable tolerance of intravenous administration of the nanoparticles. We investigated their imaging properties for arterial plaque imaging in a standard diet or a high cholesterol diet NHP, and compared their characteristics with clinically applied Gd-chelate. This preliminary investigation reports the efficient and safe imaging of atherosclerotic plaques.
authors.affiliation: Univ Lyon, Institut Lumière Matière, UMR5306, Université Claude Bernard Lyon 1, CNRS, Institut Lumière Matière, F-69622, Villeurbanne, France.
authors.forename: Shady
authors.initials: S
authors.lastname: Kotb
authors.affiliation: Univ Lyon, CARMEN Laboratory, INSERM INSA, INRA, Université Claude Bernard Lyon 1, Lyon, France.
authors.forename: Joao
authors.initials: J
authors.lastname: Piraquive
authors.affiliation: CERMEP, Imagerie du vivant, Bron 69677, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Lamberton
authors.affiliation: Univ Lyon, Institut Lumière Matière, UMR5306, Université Claude Bernard Lyon 1, CNRS, Institut Lumière Matière, F-69622, Villeurbanne, France.
authors.forename: François
authors.initials: F
authors.lastname: Lux
authors.affiliation: Cynbiose SAS, Marcy-L'Etoile, France.
authors.forename: Michael
authors.initials: M
authors.lastname: Verset
authors.affiliation: Univ Lyon, CARMEN Laboratory, INSERM INSA, INRA, Université Claude Bernard Lyon 1, Lyon, France.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Di Cataldo
authors.affiliation: Cynbiose SAS, Marcy-L'Etoile, France.
authors.forename: Hugues
authors.initials: H
authors.lastname: Contamin
authors.affiliation: Univ Lyon, Institut Lumière Matière, UMR5306, Université Claude Bernard Lyon 1, CNRS, Institut Lumière Matière, F-69622, Villeurbanne, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Tillement
authors.affiliation: Univ Lyon, CARMEN Laboratory, INSERM INSA, INRA, Université Claude Bernard Lyon 1, Lyon, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Canet-Soulas
authors.affiliation: Univ Lyon, Institut Lumière Matière, UMR5306, Université Claude Bernard Lyon 1, CNRS, Institut Lumière Matière, F-69622, Villeurbanne, France.
authors.forename: Lucie
authors.initials: L
authors.lastname: Sancey
mesh_terms: D061605:Administration, Intravenous; D000818:Animals; D050197:Atherosclerosis / Q000139:chemically induced / Q000000981:diagnostic imaging* / Q000662:veterinary; D003287:Contrast Media / Q000009:adverse effects* / Q000493:pharmacokinetics; D059305:Diet, High-Fat / Q000009:adverse effects*; D005260:Female; D005682:Gadolinium / Q000009:adverse effects* / Q000493:pharmacokinetics; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000662:veterinary; D008297:Male; D053758:Nanoparticles / Q000737:chemistry; D011323:Primates
chemical_list: D003287:Contrast Media; D005682:Gadolinium