title: Acute Rejection in Renal Transplant Patients of a Hospital in Bogota, Colombia.
abstract: BACKGROUND
  Renal transplantation is the best treatment for end stage renal disease. Acute graft rejection is one of the main complications and may influence graft survival.
  
  
  OBJECTIVE
  To determine the incidence and features of acute cellular rejection (ACR) episodes confirmed by biopsy.
  
  
  METHODS
  We studied a cohort of 175 patients who underwent renal transplantation between 2004 and 2012 to determine the cumulative incidence of ACR confirmed by biopsy and to identify the associated risk factors using multivariate analysis.
  
  
  RESULTS
  The one-year patient survival was 96.6%; the graft survival was 93.7%. The incidence of ACR within one year was 14.3%, of which 46% were observed within 6 months following transplantation. The most frequently observed ACR type was 1B according to the Banff classification system (42%). A relationship between ACR and receipt of a kidney from expanded criteria donors was observed, both in univariate and adjusted multiple log-binomial regression analyses, but only 6.3% of patients received extended criteria donor kidneys. No other relationships between variables were found.
  
  
  CONCLUSIONS
  ACR frequency in this study was similar to that of other cohorts reported previously. We need a bigger sample of renal transplants from expanded criteria donors, PRA and DSA test to support the results.
authors.affiliation: San Ignacio University Hospital; Pontificia Universidad Javeriana.
authors.forename: P
authors.initials: P
authors.lastname: García
authors.affiliation: Pontificia Universidad Javeriana.
authors.forename: M
authors.initials: M
authors.lastname: Huerfano
authors.affiliation: San Ignacio University Hospital; Pontificia Universidad Javeriana.
authors.forename: M
authors.initials: M
authors.lastname: Rodríguez
authors.affiliation: Pontificia Universidad Javeriana.
authors.forename: A
authors.initials: A
authors.lastname: Caicedo
authors.affiliation: Pontificia Universidad Javeriana.
authors.forename: F
authors.initials: F
authors.lastname: Berrío
authors.affiliation: San Ignacio University Hospital.
authors.forename: C
authors.initials: C
authors.lastname: Gonzalez
keywords: Graft rejection; Graft survival; Incidence; Kidney failure; Kidney transplantation; Renal insufficiency; chronic