title: Clinical Response to Donepezil in Mild and Moderate Dementia: Relationship to Drug Plasma Concentration and CYP2D6 and APOE Genetic Polymorphisms.
abstract: The clinical response to donepezil in patients with mild and moderate dementia was investigated in relation to the drug plasma concentration and APOE and CYP2D6 polymorphisms. In a prospective naturalistic observational study, 42 patients with Alzheimer's disease (AD) and AD with cerebrovascular disease who took donepezil (10 mg) for 12 months were evaluated. Their DNA was genotyped, and the donepezil plasma concentrations were measured after 3, 6, and 12 months. Good responders scored ≥-1 on the Mini-Mental State Examination at 12 months in comparison to the baseline score. The study results indicated the good response pattern was influenced by the concentration of donepezil, but not by APOE and CYP2D6 polymorphisms.
authors.affiliation: Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brasil.
authors.forename: Luís F J R
authors.initials: LF
authors.lastname: Miranda
authors.affiliation: Faculdade de Farmácia da Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brasil.
authors.forename: Karina B
authors.initials: KB
authors.lastname: Gomes
authors.affiliation: Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brasil.
authors.forename: Pedro A L
authors.initials: PA
authors.lastname: Tito
authors.affiliation: Faculdade de Farmácia da Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brasil.
authors.forename: Josianne N
authors.initials: JN
authors.lastname: Silveira
authors.affiliation: Faculdade de Farmácia da Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brasil.
authors.forename: Gerson A
authors.initials: GA
authors.lastname: Pianetti
authors.affiliation: Faculdade de Farmácia da Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brasil.
authors.forename: Ricardo M D
authors.initials: RM
authors.lastname: Byrro
authors.affiliation: Serviço de Neurologia do Hospital das Clínicas da Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brasil.
authors.forename: Patrícia R H
authors.initials: PR
authors.lastname: Peles
authors.affiliation: Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brasil.
authors.forename: Fernando H
authors.initials: FH
authors.lastname: Pereira
authors.affiliation: Instituto de Ciências Exatas da Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brasil.
authors.forename: Thiago R
authors.initials: TR
authors.lastname: Santos
authors.affiliation: Faculdade de Farmácia da Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brasil.
authors.forename: Arthur G
authors.initials: AG
authors.lastname: Assini
authors.affiliation: Faculdade de Farmácia da Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brasil.
authors.forename: Valéria V
authors.initials: VV
authors.lastname: Ribeiro
authors.affiliation: Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brasil.|Serviço de Geriatria do Hospital das Clínicas da Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brasil.
authors.forename: Edgar N
authors.initials: EN
authors.lastname: Moraes
authors.affiliation: Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brasil.|Serviço de Neurologia do Hospital das Clínicas da Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brasil.
authors.forename: Paulo
authors.initials: P
authors.lastname: Caramelli
mesh_terms: D001057:Apolipoproteins E / Q000235:genetics*; D002800:Cholinesterase Inhibitors / Q000097:blood* / Q000627:therapeutic use*; D002851:Chromatography, High Pressure Liquid; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D003704:Dementia / Q000097:blood / Q000188:drug therapy / Q000235:genetics; D000077265:Donepezil; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007189:Indans / Q000097:blood* / Q000627:therapeutic use*; D008297:Male; D000073216:Mental Status and Dementia Tests; D009483:Neuropsychological Tests; D010880:Piperidines / Q000097:blood* / Q000627:therapeutic use*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013997:Time Factors
chemical_list: D001057:Apolipoproteins E; D002800:Cholinesterase Inhibitors; D007189:Indans; D010880:Piperidines; D000077265:Donepezil; D019389:Cytochrome P-450 CYP2D6
keywords: APOE; Alzheimer’s disease; CYP2D6; donepezil; genetics; naturalistic study