title: An exploration of testosterone levels in patients with bipolar disorder.
abstract: BACKGROUND
  Testosterone influences well-being, mood and cognition and may play a role in the pathophysiology of bipolar disorder.
  
  
  OBJECTIVE
  To examine testosterone levels in patients with bipolar disorder compared with healthy controls.
  
  
  METHODS
  We examined baseline total testosterone levels and current depression scores in male and female patients with bipolar disorder and mild to moderate depression and healthy controls.
  
  
  RESULTS
  A significant interaction between diagnosis and gender was observed (F(2,97)=9.791,P=0.002). Testosterone levels were significantly lower for male patients with bipolar disorder compared with male controls (P=0.001). Women with bipolar disorder had significantly higher testosterone levels than female controls (P=0.03).
  
  
  CONCLUSIONS
  Disturbances in testosterone levels may represent an important neurobiological abnormality in bipolar disorder and may differ by gender. If these findings are confirmed, the use of gender appropriate treatment strategies for the normalisation of testosterone levels in bipolar disorder depression should be further explored.
  
  
  BACKGROUND
  None.
  © The Royal College of Psychiatrists 2015. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence.
authors.affiliation: , MBPsS, BSc, MSc, PhD, Centre for Affective Disorders, Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King's College London, UK.
authors.forename: Sarah C
authors.initials: SC
authors.lastname: Wooderson
authors.affiliation: , PhD, Institute of Neuroscience (Academic Psychiatry), Newcastle University, Newcastle, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Gallagher
authors.affiliation: , MBBS, MD, MRCPsych, Institute of Neuroscience, Newcastle University, Newcastle, UK.
authors.forename: Stuart
authors.initials: S
authors.lastname: Watson
authors.affiliation: , MBChB, MPhil, PhD, FRCPsych, FRCPC, Centre for Affective Disorders, IoPPN, King's College London, UK.
authors.forename: Allan H
authors.initials: AH
authors.lastname: Young