title: Cardiovascular parameters of chest CT scan in estimating pulmonary arterial pressure in patients with pulmonary hypertension.
abstract: OBJECTIVE
  To develop a formula to compute mean pulmonary arterial pressure (MPAP) by chest computerized tomography (CT), and to verify its accuracy and reliability.
  
  
  METHODS
  Eighty-five patients who had taken chest CT and right heart catheterization (RHC) were recruited. The pulmonary arterial systolic pressure (PASP), pulmonary arterial diastolic pressure (PADP), and MPAP of each subject were measured and recorded by RHC. The diameters of the ascending aorta (dAA), descending aorta (dDA) and main pulmonary artery (dMPA), Cobb angle, diameters of right ventricle (dRV), diameters of left ventricle (dLV) were measured by means of chest CT scans. Systolic blood pressure (SBP) was measured by using electronic sphygmomanometer. A linear regression equation was generated in 56 patients to estimate PAP based on chest CT values, 29 patients were used to test the accuracy of the formula.
  
  
  RESULTS
  The computed equation for analyzing MPAP is: MPAP = 9.011 + 34.195 × dMPA/dAA - 0.319 × SBP + 0.402 × Cobb angle. AUC of equation with three variables (dMPA/dAA, SBP, and Cobb angle) was 0.923 with 95% CI (0.863-0.982). The mean ± SD of predicted values and RHC values had no statistical difference.
  
  
  CONCLUSIONS
  Ratio of dMAP/dAA, Cobb angle, and SBP can be reliably used to estimate MPAP and predict severity of PH.
authors.affiliation: The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.|Ningbo Yinzhou Peoples' Hospital (The Affiliated Yinzhou Hospital of School of Medicine of Ningbo University), Ningbo, Zhejiang, China.
authors.forename: Mengxi
authors.initials: M
authors.lastname: Li
authors.affiliation: The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.|The first affiliated hospital of Shantou University Medical College, Shantou, China.
authors.forename: Shouyang
authors.initials: S
authors.lastname: Wang
authors.affiliation: The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.|Guangzhou Center for Disease Control and Prevention, Guangzhou, Guangdong, China.
authors.forename: Weiquan
authors.initials: W
authors.lastname: Lin
authors.affiliation: The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.|The Affiliated Hospital of School of Medicine of Ningbo University, Ningbo, Zhejiang, China.
authors.forename: Jinhui
authors.initials: J
authors.lastname: Li
authors.affiliation: The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.|The first affiliated hospital of Shantou University Medical College, Shantou, China.
authors.forename: Chunyang
authors.initials: C
authors.lastname: Wang
authors.affiliation: The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Huai
authors.initials: H
authors.lastname: Chen
authors.affiliation: The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Wenju
authors.initials: W
authors.lastname: Lu
authors.affiliation: The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.|State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Yang
authors.affiliation: The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.|Department of Medicine/Pulmonary, Johns Hopkins University, Baltimore, Maryland, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Qingsi
authors.initials: Q
authors.lastname: Zeng
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D001795:Blood Pressure Determination / Q000379:methods; D006328:Cardiac Catheterization / Q000379:methods; D002318:Cardiovascular Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology; D016022:Case-Control Studies; D000072226:Computed Tomography Angiography / Q000379:methods; D018450:Disease Progression; D004452:Echocardiography / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging* / Q000503:physiopathology; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011651:Pulmonary Artery / Q000000981:diagnostic imaging*; D011669:Pulmonary Wedge Pressure; D012372:ROC Curve; D013902:Radiography, Thoracic / Q000379:methods; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed / Q000379:methods*
keywords: computed tomography; estimating method; pulmonary arterial pressure; pulmonary hypertension