title: Evaluation of Cysteinyl Leukotriene Signaling as a Therapeutic Target for Colorectal Cancer.
abstract: Colorectal cancer is the third most common cancer worldwide and is associated with significant morbidity and mortality. Current pharmacotherapy options include cytotoxic chemotherapy, anti-VEGF, and anti-EGFR targeting drugs, but these are limited by toxic side effects, limited responses and ultimately resistance. Cysteinyl leukotriene (CysLT) signaling regulates intestinal homeostasis with mounting evidence suggesting that CysLT signaling also plays a role in the pathogenesis of colorectal cancer. Therefore, CysLT signaling represents a novel target for this malignancy. This review evaluates reported links between CysLT signaling and established hallmarks of cancer in addition to its pharmacological potential as a new therapeutic target.
authors.affiliation: UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College DublinDublin, Ireland; Translational Oncology, Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin, St. James's HospitalDublin, Ireland.
authors.forename: Lorraine
authors.initials: L
authors.lastname: Burke
authors.affiliation: UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin Dublin, Ireland.
authors.forename: Clare T
authors.initials: CT
authors.lastname: Butler
authors.affiliation: Department of Medical Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital Baltimore, MD, USA.
authors.forename: Adrian
authors.initials: A
authors.lastname: Murphy
authors.affiliation: UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin Dublin, Ireland.
authors.forename: Bruce
authors.initials: B
authors.lastname: Moran
authors.affiliation: UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin Dublin, Ireland.
authors.forename: William M
authors.initials: WM
authors.lastname: Gallagher
authors.affiliation: Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin, St. James's Hospital Dublin, Ireland.
authors.forename: Jacintha
authors.initials: J
authors.lastname: O'Sullivan
authors.affiliation: UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin Dublin, Ireland.
authors.forename: Breandán N
authors.initials: BN
authors.lastname: Kennedy
keywords: colorectal cancer; cysteinyl leukotriene; cysteinyl leukotriene receptor antagonist; eicosanoid; hallmarks of cancer; tumorigenesis