title: Biscylometalated iridium(iii) complexes target mitochondria or lysosomes by regulating the lipophilicity of the main ligands.
abstract: An efficient method was developed that controls biscylometalated iridium(iii) complexes to target mitochondria or lysosomes by regulating the lipophilicity of the main ligands.
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China. ceschh@mail.sysu.edu.cn.
authors.forename: Kangqiang
authors.initials: K
authors.lastname: Qiu
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China. ceschh@mail.sysu.edu.cn.
authors.forename: Yukang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China. ceschh@mail.sysu.edu.cn.
authors.forename: Huaiyi
authors.initials: H
authors.lastname: Huang
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China. ceschh@mail.sysu.edu.cn.
authors.forename: Chaofeng
authors.initials: C
authors.lastname: Liu
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China. ceschh@mail.sysu.edu.cn.
authors.forename: Hongyi
authors.initials: H
authors.lastname: Zhu
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China. ceschh@mail.sysu.edu.cn.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China. ceschh@mail.sysu.edu.cn.
authors.forename: Liangnian
authors.initials: L
authors.lastname: Ji
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China. ceschh@mail.sysu.edu.cn.
authors.forename: Hui
authors.identifier: http://orcid.org/0000-0003-4153-5303
authors.initials: H
authors.lastname: Chao
mesh_terms: D001692:Biological Transport; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D007495:Iridium / Q000737:chemistry*; D008024:Ligands; D008055:Lipids / Q000737:chemistry*; D008247:Lysosomes / Q000187:drug effects* / Q000378:metabolism; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D015394:Molecular Structure; D009025:Morpholines / Q000737:chemistry / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000737:chemistry / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D056831:Coordination Complexes; D008024:Ligands; D008055:Lipids; D009025:Morpholines; D009943:Organophosphorus Compounds; C061896:triphenylphosphine; D007495:Iridium