title: Longitudinal Lung Function Decrease in Subjects with Spontaneous Healed Pulmonary Tuberculosis.
abstract: OBJECTIVE
  We compared the longitudinal course of post-bronchodilator Forced Expiratory Volume in 1 second (pFEV1) over a 10-year period in subjects with spontaneous healed pulmonary tuberculosis (SHPTB) with that in normal subjects.
  
  
  METHODS
  We prospectively investigated 339 subjects with SHPTB and 3211 normal subjects. pFEV1 values measured biannually over 10 years were analyzed using mixed effects model.
  
  
  RESULTS
  At baseline, there were no differences in gender, smoking amount, and mean height, except mean age (50.0 ± 8.1 VS. 48.1 ± 7.3, P< 0.001) between the SHPTB and normal group. 52% of the 339 participants with SHPTB and 56% of the 3211 normal participants participated till the end of study. According to the final model, the SHPTB group showed significantly larger decrease in the average pFEV1 over the time than the normal group (P< 0.001) adjusted for gender, age, height, smoking pack years, and time effects. Especially, the interaction effect between time and group was statistically significant (P = 0.036).
  
  
  CONCLUSIONS
  The average lung function in terms of pFEV1 decreases faster in subjects with SHPTB than in normal individuals over time.
authors.affiliation: Division of Pulmonary, Sleep, and Critical Care Medicine, Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Republic of Korea.
authors.forename: Seung Heon
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Institute of Human Genomic Study, Korea University Ansan Hospital, Ansan, Republic of Korea.
authors.forename: Amy M
authors.initials: AM
authors.lastname: Kwon
authors.affiliation: Institute of Human Genomic Study, Korea University Ansan Hospital, Ansan, Republic of Korea.
authors.forename: Hae-Chung
authors.initials: HC
authors.lastname: Yang
authors.affiliation: Institute of Human Genomic Study, Korea University Ansan Hospital, Ansan, Republic of Korea.
authors.forename: Seung Ku
authors.initials: SK
authors.lastname: Lee
authors.affiliation: Division of Pulmonary, Sleep, and Critical Care Medicine, Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Republic of Korea.
authors.forename: Young
authors.initials: Y
authors.lastname: Kim
authors.affiliation: Division of Pulmonary, Sleep, and Critical Care Medicine, Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Republic of Korea.
authors.forename: Jong Hyun
authors.initials: JH
authors.lastname: Choi
authors.affiliation: Division of Pulmonary, Sleep, and Critical Care Medicine, Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Republic of Korea.
authors.forename: Je Hyeong
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Division of Pulmonary, Sleep, and Critical Care Medicine, Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Republic of Korea.|Institute of Human Genomic Study, Korea University Ansan Hospital, Ansan, Republic of Korea.
authors.forename: Chol
authors.initials: C
authors.lastname: Shin
mesh_terms: D000328:Adult; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008137:Longitudinal Studies; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014397:Tuberculosis, Pulmonary / Q000503:physiopathology*