title: Heparin-Related Thrombocytopenia Triggered by Severe Status of Systemic Lupus Erythematosus and Bacterial Infection.
abstract: A patient with severe lupus nephritis developed thrombocytopenia during treatment with high-dose steroids. In addition to viral- or disease-induced cytopenia, the pathology was believed to arise from diverse contributing factors, such as thrombotic microangiopathy and heparin-related thrombocytopenia (HIT). By combining plasma exchange therapy and intravenous cyclophosphamide, we successfully controlled the SLE activity and improved the thrombocytopenia. An antecedent bacterial infection or SLE activity is believed to have contributed to the concurrent HIT.
authors.affiliation: Department of Internal Medicine and Rheumatology, Juntendo University Nerima Hospital, Tokyo 177-8521, Japan; Department of Internal Medicine Research, Sasaki Institute, Sasaki Foundation, Tokyo 101-0062, Japan.
authors.forename: Satoshi
authors.identifier: 0000-0002-8172-2413
authors.initials: S
authors.lastname: Suzuki
authors.affiliation: Department of Internal Medicine and Rheumatology, Juntendo University Nerima Hospital, Tokyo 177-8521, Japan.
authors.forename: Shihoko
authors.initials: S
authors.lastname: Nakajima
authors.affiliation: Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo 113-8431, Japan.
authors.forename: Taiki
authors.initials: T
authors.lastname: Ando
authors.affiliation: Department of Internal Medicine and Rheumatology, Juntendo University Nerima Hospital, Tokyo 177-8521, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Oda
authors.affiliation: Department of Emergency and Critical Care Medicine, Juntendo University Nerima Hospital, Tokyo 177-8521, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Sugita
authors.affiliation: Department of Internal Medicine and Nephrology, Juntendo University Nerima Hospital, Tokyo 177-8521, Japan.
authors.forename: Kunimi
authors.initials: K
authors.lastname: Maeda
authors.affiliation: Department of Internal Medicine and Rheumatology, Juntendo University Nerima Hospital, Tokyo 177-8521, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nakiri
authors.affiliation: Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo 113-8431, Japan.
authors.forename: Yoshinari
authors.identifier: 0000-0001-7627-8445
authors.initials: Y
authors.lastname: Takasaki