title: A New Baroreceptor Sensitivity-Restoring Ca-Channel Blocker Diminishes Age-Related Morning Blood Pressure Increase in Hypertensive Patients: Open-Label Monitoring of Azelnidipine Treatment for Hypertension in the Early Morning (At-HOME) Study.
abstract: BACKGROUND
  Morning blood pressure (BP) surge, which exhibits an age-related increase, is a risk factor for stroke in elderly hypertensive patients, independently of the 24-h BP level. We studied the effect of the new baroreceptor sensitivity (BRS)-restoring Ca-channel blocker (CCB) azelnidipine (AZ) on this age-related morning BP increase.
  
  
  METHODS
  We conducted a 16-week prospective study to clarify the effect of morning dosing of AZ on home BPs measured in the morning and in the evening in 2,546 hypertensive patients (mean age, 65.1 years; female, 53.6%).
  
  
  RESULTS
  At baseline, ME-Dif (morning systolic BP [SBP]-evening SBP) increased with age, independently of ME-Ave (average of the morning and evening SBPs). This age-related increase of ME-Dif was exaggerated by regular alcohol drinking and beta-blocker use. After AZ treatment (14.3 ± 3.6 mg/day), ME-AV and ME-Dif were significantly reduced independently of each other, with reductions of -18.1 ± 15.6 and -2.5 ± 13.2 mmHg, respectively (both p < 0.001). AZ treatment decreased age-related increase in ME-Dif particularly in patients who were regular consumers of alcohol and in beta-blocker users.
  
  
  CONCLUSIONS
  The new BRS-restoring CCB AZ significantly reduced age-related increase in morning BP and had some potential benefit on cardiovascular protection in hypertension, particularly in elderly patients and/or consumers of alcohol.
authors.affiliation: Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. kkario@jichi.ac.jp.
authors.forename: Kazuomi
authors.initials: K
authors.lastname: Kario
authors.affiliation: Daiichi Sankyo Company Limited, 3-5-1 Nihonbashi-honcho, Chuo-ku, Tokyo 103-8426, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Shirayama
authors.affiliation: Daiichi Sankyo Company Limited, 3-5-1 Nihonbashi-honcho, Chuo-ku, Tokyo 103-8426, Japan.
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Hiramatsu
authors.affiliation: Daiichi Sankyo Company Limited, 3-5-1 Nihonbashi-honcho, Chuo-ku, Tokyo 103-8426, Japan.
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Shiosakai
authors.affiliation: Daiichi Sankyo Company Limited, 3-5-1 Nihonbashi-honcho, Chuo-ku, Tokyo 103-8426, Japan.
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Sugiyama
authors.affiliation: Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Shimada
keywords: azelnidipine (AZ); ca-channel blocker (CCB); morning hypertension; morning-evening blood pressure difference (ME-Dif)