title: Platelet-Derived Growth Factor in Heart Failure.
abstract: Defective vascular and cardiomyocyte function are implicated in the development and progression of both heart failure with reduced and preserved ejection fraction. Any treatment option that augments these myocardial processes may therefore be of significant value. The platelet-derived growth factor (PDGF) family is involved in a wide range of growth processes and plays a key role in both regulating angiogenesis and mesenchymal cell development. Thus, PDGF may serve as a potent therapy for heart failure. While numerous animal studies have demonstrated beneficial cardiovascular effects of growth factor therapy, promising laboratory data has not yet translated to effective therapies. In this review, we outline the biological role of PDGF and summarize previous studies that have focused on the cardiovascular effects of normal PDGF signaling, administration of PDGF, and the effects of PDGF on stem cell therapy.
authors.affiliation: School of Medicine, Stony Brook University, Stony Brook, NY, 11794-8165, USA.
authors.forename: John
authors.initials: J
authors.lastname: Medamana
authors.affiliation: Department of Dermatology, Health Science Center T16-060, Stony Brook University, Stony Brook, NY, 11794-8165, USA. richard.clark@stonybrookmedicine.edu.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Clark
authors.affiliation: Division of Cardiology, Health Science Center T16-080, Stony Brook University, Stony Brook, NY, 11794-8165, USA. javed.butler@stonybrookmedicine.edu.
authors.forename: Javed
authors.initials: J
authors.lastname: Butler
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D006333:Heart Failure / Q000378:metabolism* / Q000628:therapy; D006801:Humans; D032383:Myocytes, Cardiac / Q000378:metabolism; D018919:Neovascularization, Physiologic; D010982:Platelet-Derived Growth Factor / Q000378:metabolism* / Q000627:therapeutic use; D015398:Signal Transduction; D033581:Stem Cell Transplantation
chemical_list: D010982:Platelet-Derived Growth Factor
keywords: Angiogenesis; Animal models of human disease; Basic science research; Growth factors/cytokines; Heart failure; Journal subject code; Myocardial infarction; Stem cells