title: Further evidence for a role of the ADRB2 gene in risk for posttraumatic stress disorder.
abstract: The aim of the present study was to attempt to replicate the recently reported finding associating rs2400707 of the Adrenoceptor Beta 2, Surface (ADRB2) gene and childhood trauma on PTSD symptoms. Participants included a predominantly veteran cohort of non-Hispanic blacks (NHB; n = 949) and a pre-dominantly veteran cohort of non-Hispanic whites (NHW; n = 759). No main effects were observed for rs2400707 on PTSD diagnosis. Among the NHB participants, we observed an interaction between rs2400707 and history of childhood trauma, whereby with each additional A allele, the odds of having PTSD increased by 1.31, but only among those who had experienced childhood trauma (p = 0.038). The interaction with rs2400707 and childhood trauma was not observed among the NHW study participants (p = 0.892). Taken together, the findings from the present research provide further evidence that the adrenergic system may be an important modulator of PTSD risk; however, additional work is still needed to clarify the exact nature of the relationship between PTSD and rs2400707 of the ADRB2 gene.
authors.affiliation: Department of Medicine, Duke University Medical Center, Durham, NC, United States; Duke Molecular Physiology Institute, Durham, NC, United States. Electronic address: mike.hauser@duke.edu.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Hauser
authors.affiliation: Department of Medicine, Duke University Medical Center, Durham, NC, United States; Duke Center for Human Disease Modeling, Durham, NC, United States.
authors.forename: Melanie E
authors.initials: ME
authors.lastname: Garrett
authors.affiliation: Department of Medicine, Duke University Medical Center, Durham, NC, United States.
authors.forename: Yutao
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Durham Veterans Affairs Medical Center, Durham, NC, United States; The VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center, Durham, NC, United States; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United States.
authors.forename: Michelle F
authors.initials: MF
authors.lastname: Dennis
authors.affiliation: Durham Veterans Affairs Medical Center, Durham, NC, United States; The VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center, Durham, NC, United States; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United States.
authors.forename: Nathan A
authors.initials: NA
authors.lastname: Kimbrel
authors.affiliation: The VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center, Durham, NC, United States.
authors.lastname: Veterans Affairs Mid-Atlantic Mental Illness Research Education And Clinical Center Workgroup
authors.affiliation: Durham Veterans Affairs Medical Center, Durham, NC, United States; The VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center, Durham, NC, United States; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United States.
authors.forename: Jean C
authors.initials: JC
authors.lastname: Beckham
authors.affiliation: Department of Medicine, Duke University Medical Center, Durham, NC, United States; Duke Center for Human Disease Modeling, Durham, NC, United States.
authors.forename: Allison E
authors.initials: AE
authors.lastname: Ashley-Koch
mesh_terms: D000069586:Adult Survivors of Child Adverse Events / Q000523:psychology; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007406:Interview, Psychological; D008297:Male; D020641:Polymorphism, Single Nucleotide; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*; D012737:Sex Factors; D013313:Stress Disorders, Post-Traumatic / Q000208:ethnology / Q000235:genetics*; D011795:Surveys and Questionnaires; D014481:United States; D014493:United States Department of Veterans Affairs; D014728:Veterans
chemical_list: C553443:ADRB2 protein, human; D018343:Receptors, Adrenergic, beta-2
keywords: ADRB2; Childhood trauma; MIRECC; PTSD; Posttraumatic stress disorder; VA; Veterans