title: De novo autoimmune hepatitis after liver transplantation: A focus on glutathione S-transferase theta 1.
abstract: De novo autoimmune hepatitis (DAIH) is a rare clinical condition with features that resemble those of autoimmune hepatitis (AIH) in patients undergoing liver transplantation (LT) for nonautoimmune liver disease. The diagnosis of this entity has been based on the presence of biochemical and histological patterns similar to those observed in the primary AIH, although several considerations must be taken into account. The impact of DAIH on graft survival is relevant, and early diagnosis and treatment is associated with a good longterm outcome. Although glutathione S-transferase theta 1 (GSTT1) alloimmune recognition has been shown to be involved in the pathogenesis of DAIH, further studies are necessary to fully determine its pathogenic mechanisms and risk factors. We review the pathophysiology, the most common histological patterns, the treatment strategies, and the longterm outcomes of DAIH after LT with a special focus on GSTT1. Liver Transplantation 23:75-85 2017 AASLD.
authors.affiliation: Digestive Disease Department and Liver Transplantation Unit, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria del Hospital Gregorio Marañón, Madrid, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Ibáñez-Samaniego
authors.affiliation: Digestive Disease Department and Liver Transplantation Unit, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria del Hospital Gregorio Marañón, Madrid, Spain.|Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Madrid, Spain.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Salcedo
authors.affiliation: Digestive Disease Department and Liver Transplantation Unit, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria del Hospital Gregorio Marañón, Madrid, Spain.|Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Madrid, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Vaquero
authors.affiliation: Digestive Disease Department and Liver Transplantation Unit, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria del Hospital Gregorio Marañón, Madrid, Spain.|Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Madrid, Spain.|Facultad de Medicina, Universidad Complutense, Madrid, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Bañares
mesh_terms: D064591:Allografts / Q000276:immunology; D001323:Autoantibodies / Q000097:blood; D004359:Drug Therapy, Combination / Q000379:methods; D058625:End Stage Liver Disease / Q000601:surgery*; D005982:Glutathione Transferase / Q000276:immunology*; D006084:Graft Rejection / Q000276:immunology*; D006085:Graft Survival; D019693:Hepatitis, Autoimmune / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007519:Isoantigens / Q000276:immunology*; D008099:Liver / Q000473:pathology; D008107:Liver Diseases; D016031:Liver Transplantation / Q000009:adverse effects*; D015995:Prevalence; D012307:Risk Factors
chemical_list: D001323:Autoantibodies; D007166:Immunosuppressive Agents; D007519:Isoantigens; C413545:glutathione S-transferase T1; D005982:Glutathione Transferase