title: Nuclease activity as a specific biomarker for breast cancer.
abstract: We report on the activity of nucleases derived from cancer cells as a means for specific targeting using nucleic acid probes (substrates). We hypothesize that cancer cells can be differentiated from healthy cells based on their nuclease activity profile, and thus, any method based on this property represents a novel alternative for diagnostic and therapeutic intervention.
authors.affiliation: SOMAprobes S.L., Science and Technology Park of Gipuzkoa, San Sebastian, 20009, Spain. luiza@somaprobes.com frank.hernandez@somaprobes.com.
authors.forename: Luiza I
authors.initials: LI
authors.lastname: Hernandez
authors.forename: Veli Cengiz
authors.initials: VC
authors.lastname: Ozalp
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Hernandez
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis* / Q000378:metabolism; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000201:enzymology*; D003851:Deoxyribonucleases / Q000032:analysis* / Q000378:metabolism; D005260:Female; D006801:Humans; D015341:Nucleic Acid Probes / Q000737:chemistry* / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D015341:Nucleic Acid Probes; D003851:Deoxyribonucleases