title: PH-sensitive bionanocomposite hydrogel beads based on carboxymethyl cellulose/ZnO nanoparticle as drug carrier.
abstract: The present work explains the preparation of new pH-sensitive bionanocomposite beads based on carboxymethyl cellulose (CMC) and ZnO nanoparticles for use as controlled release drug delivery systems. Fe3+ion as physical crosslinking agent was used to prepare ionic cross-linked bionanocomposite hydrogel beads. Propranolol hydrochloride (PPN) has been chosen as a model drug. Characterization of the pH-sensitive bionanocomposite beads resulting from incorporation of different content of ZnO nanoparticles into CMC matric was carried out using different experimental techniques: XRD, FT-IR, TGA, SEM and EDX. Propranolol incorporation efficiency in beads was determined by UV-vis spectroscopy and was found to be high. Moreover, the swelling and drug release properties of the bionanocomposite hydrogels were investigated. The prepared bionanocomposite beads showed a pH sensitive swelling behavior with maximum water absorbing at pH 7.4. Also, it was found that the swelling ratio of ZnO/CMC hydrogels in different aqueous solutions was rather higher in comparison with its neat hydrogel. In vitro drug release test was carried out to prove the effectiveness of this novel type of bionanocomposite hydrogel beads as a controlled drug delivery system. A more sustained and controlled drug releases were observed for ZnONPs containing NaCMC beads, which increased by the increase in ZnONPs content.
authors.affiliation: School of Sciences, Islamic Azad University, Tabriz, Iran.
authors.forename: Zhila
authors.initials: Z
authors.lastname: Zare-Akbari
authors.affiliation: Students' Research Committee, Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: farhadnejad123@gmail.com.
authors.forename: Hassan
authors.initials: H
authors.lastname: Farhadnejad
authors.affiliation: Dezful University of Medical Sciences, Dezful, Iran.
authors.forename: Behrouz
authors.initials: B
authors.lastname: Furughi-Nia
authors.affiliation: Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Saeedeh
authors.initials: S
authors.lastname: Abedin
authors.affiliation: Faculty of Chemistry, University of Tabriz, P.O. Box 5 1666-16471, Tabriz, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Yadollahi
authors.affiliation: Materials Research Group, Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad Branch, Mashhad, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Khorsand-Ghayeni
mesh_terms: D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D055595:Mechanical Phenomena; D008863:Microspheres; D053761:Nanocomposites / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D013696:Temperature; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D002266:Carboxymethylcellulose Sodium; D015034:Zinc Oxide
keywords: Carboxymethyl cellulose hydrogel; Drug carrier; ZnO nanoparticles; pH-sensitive