title: Deficiency in memory B cell compartment in a patient with infertility and recurrent pregnancy losses.
abstract: Alterations in normal balance of B cell subsets have been reported in various rheumatic diseases. In this study, we report a woman with a history of recurrent pregnancy losses (RPL) and infertility who had low levels of memory B cells. A 35-year-old woman with a history of RPL and infertility was demonstrated to have increased peripheral blood CD19+ B cells with persistently low levels of memory B cell subsets. Prior to the frozen donor egg transfer cycle, prednisone and intravenous immunoglobulin G (IVIg) treatment was initiated and patient achieved dichorionic diamniotic twin pregnancies. During pregnancy, proportion (%) of switched memory B cells CD27+IgD- increased, while percent of total CD19+ B cells and CD27-IgD+ naive B cells were gradually decreased with a high dose IVIg treatment. She developed cervical incompetence at 20 weeks of gestation, received a Cesarean section at 32 weeks of gestation due to preterm labor, and delivered twin babies. B cell subset abnormalities may be associated with infertility, RPL and preterm labor, and further investigation is needed.
authors.affiliation: Reproductive Medicine, Department of Obstetrics and Gynecology, Chicago Medical School at Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, 60061, USA.
authors.forename: N
authors.initials: N
authors.lastname: Sung
authors.affiliation: Yonsei University, College of Medicine, Seoul, Republic of Korea.
authors.forename: H J
authors.initials: HJ
authors.lastname: Byeon
authors.affiliation: Reproductive Medicine, Department of Obstetrics and Gynecology, Chicago Medical School at Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, 60061, USA.
authors.forename: M D Salazar
authors.initials: MDS
authors.lastname: Garcia
authors.affiliation: Reproductive Medicine, Department of Obstetrics and Gynecology, Chicago Medical School at Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, 60061, USA.
authors.forename: A
authors.initials: A
authors.lastname: Skariah
authors.affiliation: Reproductive Medicine, Department of Obstetrics and Gynecology, Chicago Medical School at Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, 60061, USA.
authors.forename: L
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Microbiology and Immunology, Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, IL, 60069, USA.
authors.forename: S
authors.initials: S
authors.lastname: Dambaeva
authors.affiliation: Department of Microbiology and Immunology, Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, IL, 60069, USA.
authors.forename: K
authors.initials: K
authors.lastname: Beaman
authors.affiliation: Department of Microbiology and Immunology, Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, IL, 60069, USA.
authors.forename: A
authors.initials: A
authors.lastname: Gilman-Sachs
authors.affiliation: Reproductive Medicine, Department of Obstetrics and Gynecology, Chicago Medical School at Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, 60061, USA; Department of Microbiology and Immunology, Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, IL, 60069, USA. Electronic address: joanne.kwakkim@rosalindfranklin.edu.
authors.forename: J
authors.initials: J
authors.lastname: Kwak-Kim
mesh_terms: D000026:Abortion, Habitual / Q000276:immunology* / Q000628:therapy; D000328:Adult; D018941:Antigens, CD19 / Q000378:metabolism; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D006801:Humans; D017578:Immunoglobulin Class Switching; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007156:Immunologic Memory; D007247:Infertility, Female / Q000276:immunology* / Q000628:therapy; D007752:Obstetric Labor, Premature / Q000276:immunology*; D011241:Prednisone / Q000627:therapeutic use*; D011247:Pregnancy / Q000276:immunology
chemical_list: D018941:Antigens, CD19; D016756:Immunoglobulins, Intravenous; D011241:Prednisone
keywords: B cell; Infertility; Memory B cell; Preterm; Recurrent pregnancy loss