title: Cancer Diagnosis and Imaging-Guided Photothermal Therapy Using a Dual-Modality Nanoparticle.
abstract: To improve patient outcome and decrease overall health-care costs, highly sensitive and precise detection of a tumor is required for its accurate diagnosis and efficient therapy; however, this remains a challenge when using conventional single mode imaging. Here, we successfully designed a near-infrared (NIR)-response photothermal therapy (PTT) platform (Au@MSNs-ICG) for the location, diagnosis, and NIR/computer tomography (CT) bimodal imaging-guided PTT of tumor tissues, using gold (Au) nanospheres coated with indocyanine green (ICG)-loaded mesoporous silica nanoparticles (MSNs), which would have high sensitivity and precision. The nanoparticles (NPs) exhibited good monodispersity, fluorescence stability, biocompatibility, and NIR/CT signaling and had a preferable temperature response under NIR laser irradiation in vitro or in vivo. Using a combination of NIR/CT imaging and PTT treatment, the tumor could be accurately positioned and thoroughly eradicated in vivo by Au@MSNs-ICG injection. Hence, the multifunctional NPs could play an important role in facilitating the accurate treatment of tumors in future clinical applications.
authors.affiliation: Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences , Beijing 100190, China.|Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University , No. 253, Gongye Avenue, Guangzhou 510280, China.
authors.forename: Chaoting
authors.initials: C
authors.lastname: Zeng
authors.affiliation: Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences , Beijing 100190, China.|Beijing Key Laboratory of Molecular Imaging , Zhongguancun East Road #95, Haidian District, Beijing 100190, China.
authors.forename: Wenting
authors.initials: W
authors.lastname: Shang
authors.affiliation: Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences , Beijing 100190, China.|Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University , No. 253, Gongye Avenue, Guangzhou 510280, China.
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Liang
authors.affiliation: Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences , Beijing 100190, China.|Beijing Key Laboratory of Molecular Imaging , Zhongguancun East Road #95, Haidian District, Beijing 100190, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Liang
authors.affiliation: Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences , Beijing 100190, China.|Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University , No. 253, Gongye Avenue, Guangzhou 510280, China.
authors.forename: Qingshan
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences , Beijing 100190, China.|Beijing Key Laboratory of Molecular Imaging , Zhongguancun East Road #95, Haidian District, Beijing 100190, China.
authors.forename: Chongwei
authors.initials: C
authors.lastname: Chi
authors.affiliation: Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences , Beijing 100190, China.|Beijing Key Laboratory of Molecular Imaging , Zhongguancun East Road #95, Haidian District, Beijing 100190, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Du
authors.affiliation: Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University , No. 253, Gongye Avenue, Guangzhou 510280, China.
authors.forename: Chihua
authors.initials: C
authors.lastname: Fang
authors.affiliation: Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences , Beijing 100190, China.|Beijing Key Laboratory of Molecular Imaging , Zhongguancun East Road #95, Haidian District, Beijing 100190, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Tian
mesh_terms: D006801:Humans; D007208:Indocyanine Green; D053758:Nanoparticles; D009369:Neoplasms; D010789:Phototherapy; D000068936:Theranostic Nanomedicine
chemical_list: D007208:Indocyanine Green
keywords: NIR fluorescence imaging; computed tomography; gold nanospheres; imaging-guided therapy; indocyanine green; photothermal therapy