title: Relevance Study on Cerebral Infarction and Resistin Gene Polymorphism in Chinese Han Population.
abstract: Recent research on genome-wide associations has implicated that the serum resistin level and its gene polymorphism are associated with cerebral infarction (CI) morbidity and prognosis, and could thereby regulate CI. This study aimed to investigate the association between the resistin single nucleotide polymorphism (SNP) and the susceptibility to CI in the Chinese Han population. A total of 550 CI patients and 313 healthy controls were genotyped. Nine SNPs of the resistin gene previously shown were sequenced and assessed for an association with CI. The numbers of GG genotype carriers of rs3219175 and rs3486119 in the CI group were significantly higher than those in the control group among the middle-aged group (aged 45-65), at 76% vs 67.9% (P=0.025) and 75.5% vs 67.9% (P=0.031). rs3219175 and rs34861192 were associated with CI in the dominant and superdominant models according to the genetic model analysis (P<0.05). Meanwhile, there was strong linkage disequilibrium among the rs34124816, rs3219175, rs34861192, rs1862513, rs3745367, 180C/G and rs3745369 sites. In a haplotype analysis, the occurrence rate of the haplotype AGGCAGC was 1.97 times (P<0.05) higher in the patient group than in the control group. In addition, the numbers of GG genotype carriers of rs3219175 and rs3486119 in the middle-aged male CI patients and the middle-aged small artery occlusion (SAO) CI patients were higher than those in the control group (P<0.05). In the Chinese Han middle-aged population, the GG gene type carriers of the resistin gene sites rs3219175 and rs34861192 had a high risk for CI onset, especially in middle-aged male patients and SAO CI in all middle-aged patients.
authors.affiliation: 1Department of Neurology & Institute of Neurology, and.
authors.forename: Aijuan
authors.initials: A
authors.lastname: Yan
authors.affiliation: 1Department of Neurology & Institute of Neurology, and.
authors.forename: Gaoyu
authors.initials: G
authors.lastname: Cai
authors.affiliation: 1Department of Neurology & Institute of Neurology, and.
authors.forename: Ningzhen
authors.initials: N
authors.lastname: Fu
authors.affiliation: 3Department of Neurology, Minhang Central Hospital, Shanghai 201100, China.
authors.forename: Yulan
authors.initials: Y
authors.lastname: Feng
authors.affiliation: 4Department of Neurology, Gongli Hospital, Shanghai 200135, China.
authors.forename: Jialan
authors.initials: J
authors.lastname: Sun
authors.affiliation: 5Department of Neurology, the Second People's Hospital of Kashgar, Kashgar 844000, China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Maimaiti
authors.affiliation: 2Emergency Department, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
authors.forename: Weijun
authors.initials: W
authors.lastname: Zhou
authors.affiliation: 1Department of Neurology & Institute of Neurology, and.
authors.forename: Yi
authors.initials: Y
authors.lastname: Fu
keywords: Cerebral infarction; Male; Resistin; Single nucleotide polymorphism; Small artery occlusion type