title: Pd-Catalyzed Tandem Cyclization via C-H Arylation and Acylation for the Construction of Polycyclic Scaffolds.
abstract: The first Pd-catalyzed tandem cyclization of imidazo[1,2-a]pyridines with 2-chlorobenzaldehydes through C-H arylation and acylation is presented for the efficient synthesis of novel 6H-benzo[b]imidazo[5,1,2-de]quinolizin-6-ones. The direct acylation reaction proceeded smoothly without the aid of directing groups and in the presence of air as a clean and free terminal oxidant.
authors.affiliation: The College of Chemistry and Molecular Engineering, Zhengzhou University , Zhengzhou 450052, P. R. China.|The College of Chemistry and Chemical Engineering, Zhengzhou Normal University , Zhengzhou 450044, P. R. China.|Medical School, Huanghe Science and Technology College , Zhengzhou 450000, P. R. China.
authors.forename: Bing
authors.initials: B
authors.lastname: Mu
authors.affiliation: Tetranov Biopharm, LLC, Zhengzhou 450052, P. R. China.
authors.forename: Jingya
authors.initials: J
authors.lastname: Li
authors.affiliation: The College of Chemistry and Molecular Engineering, Zhengzhou University , Zhengzhou 450052, P. R. China.
authors.forename: Dapeng
authors.initials: D
authors.lastname: Zou
authors.affiliation: The College of Chemistry and Molecular Engineering, Zhengzhou University , Zhengzhou 450052, P. R. China.|Tetranov Biopharm, LLC, Zhengzhou 450052, P. R. China.
authors.forename: Yusheng
authors.initials: Y
authors.lastname: Wu
authors.affiliation: The College of Chemistry and Molecular Engineering, Zhengzhou University , Zhengzhou 450052, P. R. China.
authors.forename: Junbiao
authors.initials: J
authors.lastname: Chang
authors.affiliation: The College of Chemistry and Molecular Engineering, Zhengzhou University , Zhengzhou 450052, P. R. China.
authors.forename: Yangjie
authors.initials: Y
authors.lastname: Wu