title: Antineuronal Nuclear Autoantibody Type 1/Anti-Hu-Associated Opsoclonus Myoclonus and Epilepsia Partialis Continua: Case Report and Literature Review.
abstract: Opsoclonus-myoclonus syndrome is a rare clinical condition that has been associated with neuroblastoma. There are few reported examples of ANNA-1/anti-Hu antibodies in children with neuroblastoma and opsoclonus-myoclonus, all in children aged less than three years of age.
  
  
  
  We describe the new onset of focal seizures without alteration of consciousness and opsoclonus-myoclonus in an 11-year-old girl with ANNA-1/anti-Hu positivity and a paraspinal ganglioneuroblastoma. A systematic review of the literature of children with ANNA-1/anti-Hu positivity and malignancy was also performed.
  
  
  
  Fourteen patients were identified, eight of whom had opsoclonus-myoclonus. Although epilepsia partialis continua has been described in association with several neuronal autoantibodies, association with ANNA-1/anti-Hu has not been reported.
  
  
  
  We describe epilepsia partialis continua in a child with ANNA-1/anti-Hu antibodies and neuroblastoma. Testing for antineuronal antibodies should be considered in children presenting with either opsoclonus-myoclonus or epilepsia partialis continua.
authors.affiliation: Department of Neurology, University of Utah, Salt Lake City, Utah. Electronic address: michael.sweeney.1@louisville.edu.
authors.forename: Michael
authors.initials: M
authors.lastname: Sweeney
authors.affiliation: Division of Neurology, Primary Children's Hospital, Salt Lake City, Utah.
authors.forename: Matthew
authors.initials: M
authors.lastname: Sweney
authors.affiliation: Department of Neurology, University of Utah, Salt Lake City, Utah.
authors.forename: M Mateo Paz
authors.initials: MM
authors.lastname: Soldán
authors.affiliation: Department of Neurology, University of Utah, Salt Lake City, Utah.
authors.forename: Stacey L
authors.initials: SL
authors.lastname: Clardy
mesh_terms: D000912:Antibodies, Neoplasm / Q000097:blood / Q000134:cerebrospinal fluid; D001323:Autoantibodies / Q000097:blood / Q000134:cerebrospinal fluid; D002648:Child; D051959:ELAV Proteins / Q000097:blood / Q000134:cerebrospinal fluid; D017036:Epilepsia Partialis Continua / Q000097:blood / Q000134:cerebrospinal fluid / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D053578:Opsoclonus-Myoclonus Syndrome / Q000097:blood / Q000134:cerebrospinal fluid / Q000000981:diagnostic imaging*; D013125:Spinal Neoplasms / Q000097:blood / Q000134:cerebrospinal fluid / Q000000981:diagnostic imaging*
chemical_list: D000912:Antibodies, Neoplasm; D001323:Autoantibodies; D051959:ELAV Proteins
keywords: anti-Hu; antineuronal nuclear antibody; epilepsia partialis continua; neuroblastoma; opsoclonus-myoclonus; type 1 (ANNA-1)