title: Caveolin-1 is overexpressed in hypopharyngeal squamous cell carcinoma and correlates with clinical parameters.
abstract: The present study aimed to identify the role of caveolin-1 (CAV1) in hypopharyngeal squamous cell carcinoma (HSCC) and identify its possible correlation with tumor clinical parameters. Expression of CAV1 was measured using immunohistochemical staining of 66 HSCC samples and 44 samples from morphologically normal tissues adjacent to the carcinomas. Expression of CAV1 in HSCC and paracancerous tissues were 71.2 and 9.5% respectively. Levels of CAV1 expression were significantly associated with tumor differentiation, tumor-node-metastasis stage and lymph nodes metastasis (P<0.05). The present study identified that expression of CAV1 in HSCC is significantly higher than in paracancerous tissues, suggesting that this high expression of CAV1 is associated with tumor invasion and metastasis.
authors.affiliation: Department of Comprehensive Health II, Shandong Provincial Hospital Affiliated to Shandong University, Shandong 250021, P.R. China.
authors.forename: Xuening
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Comprehensive Health II, Shandong Provincial Hospital Affiliated to Shandong University, Shandong 250021, P.R. China.
authors.forename: Gang
authors.initials: G
authors.lastname: Yu
authors.affiliation: Department of Otolaryngology, Qilu Hospital of Shandong University, Jinan, Shandong 250031, P.R. China.
authors.forename: Xuemin
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Otolaryngology, Qilu Hospital of Shandong University, Jinan, Shandong 250031, P.R. China.
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Otolaryngology, Qilu Hospital of Shandong University, Jinan, Shandong 250031, P.R. China.
authors.forename: Xinliang
authors.initials: X
authors.lastname: Pan
keywords: caveolin-1; hypopharyngeal carcinoma; immunohistochemistry; lymph node metastasis