title: Determining Metacarpophalangeal Flexion Angle Tolerance for Reliable Volumetric Joint Space Measurements by High-resolution Peripheral Quantitative Computed Tomography.
abstract: The position-dependence of a method to measure the joint space of metacarpophalangeal (MCP) joints using high-resolution peripheral quantitative computed tomography (HR-pQCT) was studied.
  
  
  
  Cadaveric MCP were imaged at 7 flexion angles between 0 and 30 degrees. The variability in reproducibility for mean, minimum, and maximum joint space widths and volume measurements was calculated for increasing degrees of flexion.
  
  
  
  Root mean square coefficient of variance values were < 5% under 20 degrees of flexion for mean, maximum, and volumetric joint spaces. Values for minimum joint space width were optimized under 10 degrees of flexion.
  
  
  
  MCP joint space measurements should be acquired at < 10 degrees of flexion in longitudinal studies.
authors.affiliation: From the Department of Medicine, Faculty of Medicine, University of Toronto, Toronto; Department of Mechanical Engineering, University of Waterloo, Waterloo, Ontario; McCaig Institute for Bone and Joint Health, University of Calgary; the departments of Radiology and Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA; Institute for Biomechanics, ETH Zurich, Zurich, Switzerland; Schulich School of Engineering, University of Calgary; Faculty of Kinesiology, and Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.S. Tom, MD, Rheumatology Resident, Department of Medicine, Faculty of Medicine, University of Toronto; M. Frayne, Bachelor of Applied Science Student, Mechanical Engineering, Department of Mechanical Engineering, University of Waterloo, and McCaig Institute for Bone and Joint Health, University of Calgary; S.L. Manske, PhD, Research Associate, McCaig Institute for Bone and Joint Health, University of Calgary, and Department of Radiology, Cumming School of Medicine, University of Calgary; A.J. Burghardt, BS, Research Specialist, Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco; K.S. Stok, PhD, Senior Research Associate, Institute for Biomechanics, ETH Zurich; S.K. Boyd, PhD, Professor, Department of Radiology, McCaig Institute for Bone and Joint Health, and Department of Radiology, Cumming School of Medicine, and Schulich School of Engineering, and Faculty of Kinesiology, University of Calgary; C. Barnabe, MD, MSc, Assistant Professor, Department of Medicine and Department of Community Health Sciences, and McCaig Institute for Bone and Joint Health, University of Calgary.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Tom
authors.affiliation: From the Department of Medicine, Faculty of Medicine, University of Toronto, Toronto; Department of Mechanical Engineering, University of Waterloo, Waterloo, Ontario; McCaig Institute for Bone and Joint Health, University of Calgary; the departments of Radiology and Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA; Institute for Biomechanics, ETH Zurich, Zurich, Switzerland; Schulich School of Engineering, University of Calgary; Faculty of Kinesiology, and Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.S. Tom, MD, Rheumatology Resident, Department of Medicine, Faculty of Medicine, University of Toronto; M. Frayne, Bachelor of Applied Science Student, Mechanical Engineering, Department of Mechanical Engineering, University of Waterloo, and McCaig Institute for Bone and Joint Health, University of Calgary; S.L. Manske, PhD, Research Associate, McCaig Institute for Bone and Joint Health, University of Calgary, and Department of Radiology, Cumming School of Medicine, University of Calgary; A.J. Burghardt, BS, Research Specialist, Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco; K.S. Stok, PhD, Senior Research Associate, Institute for Biomechanics, ETH Zurich; S.K. Boyd, PhD, Professor, Department of Radiology, McCaig Institute for Bone and Joint Health, and Department of Radiology, Cumming School of Medicine, and Schulich School of Engineering, and Faculty of Kinesiology, University of Calgary; C. Barnabe, MD, MSc, Assistant Professor, Department of Medicine and Department of Community Health Sciences, and McCaig Institute for Bone and Joint Health, University of Calgary.
authors.forename: Mark
authors.initials: M
authors.lastname: Frayne
authors.affiliation: From the Department of Medicine, Faculty of Medicine, University of Toronto, Toronto; Department of Mechanical Engineering, University of Waterloo, Waterloo, Ontario; McCaig Institute for Bone and Joint Health, University of Calgary; the departments of Radiology and Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA; Institute for Biomechanics, ETH Zurich, Zurich, Switzerland; Schulich School of Engineering, University of Calgary; Faculty of Kinesiology, and Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.S. Tom, MD, Rheumatology Resident, Department of Medicine, Faculty of Medicine, University of Toronto; M. Frayne, Bachelor of Applied Science Student, Mechanical Engineering, Department of Mechanical Engineering, University of Waterloo, and McCaig Institute for Bone and Joint Health, University of Calgary; S.L. Manske, PhD, Research Associate, McCaig Institute for Bone and Joint Health, University of Calgary, and Department of Radiology, Cumming School of Medicine, University of Calgary; A.J. Burghardt, BS, Research Specialist, Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco; K.S. Stok, PhD, Senior Research Associate, Institute for Biomechanics, ETH Zurich; S.K. Boyd, PhD, Professor, Department of Radiology, McCaig Institute for Bone and Joint Health, and Department of Radiology, Cumming School of Medicine, and Schulich School of Engineering, and Faculty of Kinesiology, University of Calgary; C. Barnabe, MD, MSc, Assistant Professor, Department of Medicine and Department of Community Health Sciences, and McCaig Institute for Bone and Joint Health, University of Calgary.
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Manske
authors.affiliation: From the Department of Medicine, Faculty of Medicine, University of Toronto, Toronto; Department of Mechanical Engineering, University of Waterloo, Waterloo, Ontario; McCaig Institute for Bone and Joint Health, University of Calgary; the departments of Radiology and Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA; Institute for Biomechanics, ETH Zurich, Zurich, Switzerland; Schulich School of Engineering, University of Calgary; Faculty of Kinesiology, and Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.S. Tom, MD, Rheumatology Resident, Department of Medicine, Faculty of Medicine, University of Toronto; M. Frayne, Bachelor of Applied Science Student, Mechanical Engineering, Department of Mechanical Engineering, University of Waterloo, and McCaig Institute for Bone and Joint Health, University of Calgary; S.L. Manske, PhD, Research Associate, McCaig Institute for Bone and Joint Health, University of Calgary, and Department of Radiology, Cumming School of Medicine, University of Calgary; A.J. Burghardt, BS, Research Specialist, Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco; K.S. Stok, PhD, Senior Research Associate, Institute for Biomechanics, ETH Zurich; S.K. Boyd, PhD, Professor, Department of Radiology, McCaig Institute for Bone and Joint Health, and Department of Radiology, Cumming School of Medicine, and Schulich School of Engineering, and Faculty of Kinesiology, University of Calgary; C. Barnabe, MD, MSc, Assistant Professor, Department of Medicine and Department of Community Health Sciences, and McCaig Institute for Bone and Joint Health, University of Calgary.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Burghardt
authors.affiliation: From the Department of Medicine, Faculty of Medicine, University of Toronto, Toronto; Department of Mechanical Engineering, University of Waterloo, Waterloo, Ontario; McCaig Institute for Bone and Joint Health, University of Calgary; the departments of Radiology and Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA; Institute for Biomechanics, ETH Zurich, Zurich, Switzerland; Schulich School of Engineering, University of Calgary; Faculty of Kinesiology, and Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.S. Tom, MD, Rheumatology Resident, Department of Medicine, Faculty of Medicine, University of Toronto; M. Frayne, Bachelor of Applied Science Student, Mechanical Engineering, Department of Mechanical Engineering, University of Waterloo, and McCaig Institute for Bone and Joint Health, University of Calgary; S.L. Manske, PhD, Research Associate, McCaig Institute for Bone and Joint Health, University of Calgary, and Department of Radiology, Cumming School of Medicine, University of Calgary; A.J. Burghardt, BS, Research Specialist, Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco; K.S. Stok, PhD, Senior Research Associate, Institute for Biomechanics, ETH Zurich; S.K. Boyd, PhD, Professor, Department of Radiology, McCaig Institute for Bone and Joint Health, and Department of Radiology, Cumming School of Medicine, and Schulich School of Engineering, and Faculty of Kinesiology, University of Calgary; C. Barnabe, MD, MSc, Assistant Professor, Department of Medicine and Department of Community Health Sciences, and McCaig Institute for Bone and Joint Health, University of Calgary.
authors.forename: Kathryn S
authors.initials: KS
authors.lastname: Stok
authors.affiliation: From the Department of Medicine, Faculty of Medicine, University of Toronto, Toronto; Department of Mechanical Engineering, University of Waterloo, Waterloo, Ontario; McCaig Institute for Bone and Joint Health, University of Calgary; the departments of Radiology and Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA; Institute for Biomechanics, ETH Zurich, Zurich, Switzerland; Schulich School of Engineering, University of Calgary; Faculty of Kinesiology, and Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.S. Tom, MD, Rheumatology Resident, Department of Medicine, Faculty of Medicine, University of Toronto; M. Frayne, Bachelor of Applied Science Student, Mechanical Engineering, Department of Mechanical Engineering, University of Waterloo, and McCaig Institute for Bone and Joint Health, University of Calgary; S.L. Manske, PhD, Research Associate, McCaig Institute for Bone and Joint Health, University of Calgary, and Department of Radiology, Cumming School of Medicine, University of Calgary; A.J. Burghardt, BS, Research Specialist, Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco; K.S. Stok, PhD, Senior Research Associate, Institute for Biomechanics, ETH Zurich; S.K. Boyd, PhD, Professor, Department of Radiology, McCaig Institute for Bone and Joint Health, and Department of Radiology, Cumming School of Medicine, and Schulich School of Engineering, and Faculty of Kinesiology, University of Calgary; C. Barnabe, MD, MSc, Assistant Professor, Department of Medicine and Department of Community Health Sciences, and McCaig Institute for Bone and Joint Health, University of Calgary.
authors.forename: Steven K
authors.initials: SK
authors.lastname: Boyd
authors.affiliation: From the Department of Medicine, Faculty of Medicine, University of Toronto, Toronto; Department of Mechanical Engineering, University of Waterloo, Waterloo, Ontario; McCaig Institute for Bone and Joint Health, University of Calgary; the departments of Radiology and Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA; Institute for Biomechanics, ETH Zurich, Zurich, Switzerland; Schulich School of Engineering, University of Calgary; Faculty of Kinesiology, and Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.S. Tom, MD, Rheumatology Resident, Department of Medicine, Faculty of Medicine, University of Toronto; M. Frayne, Bachelor of Applied Science Student, Mechanical Engineering, Department of Mechanical Engineering, University of Waterloo, and McCaig Institute for Bone and Joint Health, University of Calgary; S.L. Manske, PhD, Research Associate, McCaig Institute for Bone and Joint Health, University of Calgary, and Department of Radiology, Cumming School of Medicine, University of Calgary; A.J. Burghardt, BS, Research Specialist, Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco; K.S. Stok, PhD, Senior Research Associate, Institute for Biomechanics, ETH Zurich; S.K. Boyd, PhD, Professor, Department of Radiology, McCaig Institute for Bone and Joint Health, and Department of Radiology, Cumming School of Medicine, and Schulich School of Engineering, and Faculty of Kinesiology, University of Calgary; C. Barnabe, MD, MSc, Assistant Professor, Department of Medicine and Department of Community Health Sciences, and McCaig Institute for Bone and Joint Health, University of Calgary. ccbarnab@ucalgary.ca.
authors.forename: Cheryl
authors.initials: C
authors.lastname: Barnabe
mesh_terms: D006801:Humans; D008662:Metacarpophalangeal Joint / Q000000981:diagnostic imaging*; D016059:Range of Motion, Articular / Q000502:physiology*; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed
keywords: HIGH-RESOLUTION PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY; JOINT SPACE NARROWING; OSTEOARTHRITIS; RHEUMATOID ARTHRITIS