title: Non-halogenated new sesquiterpenes from Bornean Laurencia snackeyi.
abstract: Two new non-halogenated sesquiterpenes, snakeol (1) and snakediol (2) were isolated together with 9 known sesquiterpenes such as (R,Z)-33-dimethyl-5-methylene-4-(3-methylpenta-24-dien-1-yl)cyclohex-1-ene (3), palisol (4), pacifigorgiol (5), palisadin D (6), palisadin A (7), palisadin B (8), 5-acetoxypalisadin B (9), debromolaurinterol (10) and α-bromocuparane (11) from the red algae Laurencia snackeyi. The structures of two new metabolites were determined from their spectroscopic data (IR, 1D and 2D NMR and MS). Compounds 1, 2, 10 and 11 showed strong antibacterial activity against selected human clinical bacterial pathogens.
authors.affiliation: a Laboratory of Natural Products Chemistry , Institute for Tropical Biology and Conservation, University of Malaysia Sabah , Kota Kinabalu , Malaysia.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kamada
authors.affiliation: a Laboratory of Natural Products Chemistry , Institute for Tropical Biology and Conservation, University of Malaysia Sabah , Kota Kinabalu , Malaysia.
authors.forename: Charles Santhanaraju
authors.initials: CS
authors.lastname: Vairappan
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification; D054879:Halogenation; D006801:Humans; D044722:Laurencia / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D000461:Rhodophyta / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D012717:Sesquiterpenes; C505296:palisadin B
keywords: Laurencia snackeyi; Red alga; antibacterial activity; chemical race; rhodomelaceae; sesquiterpene