title: Long-term efficacy of liraglutide in Indian patients with Type 2 diabetes in a real-world setting.
abstract: BACKGROUND
  Long-term efficacy of liraglutide, a glucagon-like peptide-1 analog, on body weight and glycemic control has not been studied in Indian Type 2 diabetes mellitus (T2DM) subjects.
  
  
  OBJECTIVE
  To evaluate the effect of liraglutide on glycemic control and body weight for 1 year in Indian T2DM patients.
  
  
  METHODS
  Liraglutide was prescribed to 96 obese patients with T2DM and followed up for 1 year. Clinical parameters were measured at baseline and 3, 6, 9, and 12 months. Dosage of liraglutide and other medications was adjusted according to clinical judgment.
  
  
  RESULTS
  1 year data were available for 74 patients. Mean age was 50.9 ± 9.6 years. Mean duration of diabetes was 11.6 ± 6.3 years. Glycosylated hemoglobin (HbA1c) significantly decreased from 8.9 ± 1.3% at baseline to 7.4 ± 1.2% at 1 year. Body weight significantly declined from 98.9 ± 16.0 kg at baseline to 93.8 ± 15.0 kg at 1 year. After an initial decline, subset of patients had an increase in mean HbA1c (n= 30/74) and mean body weight (n= 33/74) after 6 months of liraglutide initiation. Baseline HbA1c and baseline body weight were positively associated with a reduction of HbA1c and body weight at 1 year, respectively. No major side effects occurred.
  
  
  CONCLUSIONS
  Liraglutide treatment resulted in a significant and sustained reduction in HbA1c and body weight over 1 year in Indian T2DM patients. Magnitude of reduction of HbA1c and body weight at 1 year was positively associated with baseline HbA1c and baseline weight, respectively.
authors.affiliation: Division of Endocrinology and Diabetes, Medanta - The Medicity, Gurgaon, Haryana, India.
authors.forename: Parjeet
authors.initials: P
authors.lastname: Kaur
authors.affiliation: Division of Endocrinology and Diabetes, Medanta - The Medicity, Gurgaon, Haryana, India.
authors.forename: Shama
authors.initials: S
authors.lastname: Mahendru
authors.affiliation: Division of Endocrinology and Diabetes, Medanta - The Medicity, Gurgaon, Haryana, India.
authors.forename: Ambrish
authors.initials: A
authors.lastname: Mithal
keywords: Diabetes; India; liraglutide; obesity