title: Correlation between serum level of chemokine (C-C motif) ligand 18 and poor prognosis in breast cancer.
abstract: In this study, we investigated the correlation between serum chemokine (C-C motif) ligand 18 (CCL-18) and the prognosis as well as clinical characteristics of breast cancer. Blood samples from 207 breast cancer patients, 126 individuals with benign breast tumors, and 93 healthy women were collected. Serum CCL-18 expression was detected by enzyme-linked immunosorbent assay. Mann-Whitney's U tests were carried out to analyze the relationship between serum CCL-18 and clinicopathological variables. The Kaplan-Meier method was used to evaluate the overall survival (OS), whereas differences between groups were analyzed by log-rank tests. The COX proportional hazard regression model was used to determine the association between clinicopathological characteristics and survival. We found that serum CCL-18 was significantly higher in breast cancer patients (290.06 ± 89.52 pg/mL) as compared to that in individuals with benign tumors (170.14 ± 26.57 pg/mL) or healthy women (119.36 ± 38.77 pg/mL) (P < 0.05). Serum CCL-18 was correlated with clinical cancer stages (P = 0.007), and was associated with advanced cancer stage (P < 0.05). The 5-year OS rate of breast cancer patients with high serum CCL- 18 was 35.9% (HR = 3.908, 95%CI = 2.546-12.090, P < 0.05), which was significantly lower as compared to that for patients with low serum CCL-18 (85.5%). Based on our results, we conclude that CCL-18 is a prognostic biomarker in patients with advanced breast cancer in Chinese patients.
authors.affiliation: Xianyang Hospital of Yan'an University Clinical Laboratory, Xianyang, China sunjihong_l@163.com.
authors.forename: J H
authors.initials: JH
authors.lastname: Sun
authors.affiliation: The First People's Hospital of Xianyang, Xianyang, China.
authors.forename: N
authors.initials: N
authors.lastname: Fan
authors.affiliation: Xianyang Hospital of Yan'an University Clinical Laboratory, Xianyang, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood* / Q000473:pathology; D002277:Carcinoma / Q000097:blood* / Q000473:pathology; D016022:Case-Control Studies; D019742:Chemokines, CC / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged
chemical_list: D014408:Biomarkers, Tumor; C111792:CCL18 protein, human; D019742:Chemokines, CC