title: Microstructured β-Tricalcium Phosphate Putty Versus Autologous Bone for Repair of Alveolar Clefts in a Goat Model.
abstract: For the first time it was demonstrated that an osteoinductive calcium phosphate-based putty is effective in the restoration of complex maxillofacial defects. In these defects, adequate mechanical confinement by multiple bony walls and osteoconduction from multiple surfaces are usually lacking. This study compares the efficacy of a microstructured beta-tricalcium phosphate (β-TCP) putty with autologous bone for the repair of alveolar cleft defects. A total of 10 Dutch milk goats were operated on in a split-mouth study design in which two-wall bony alveolar clefts were created and successively repaired with autologous bone (the gold standard) at one side and β-TCP putty at the other. After 24 weeks of implantation, histomorphometric and micro-computer tomography analyses proved that the β-TCP putty group showed equal bone quality and volume to clefts reconstructed with autologous bone. In addition, surgical handling of the putty is superior to the use of calcium phosphates in a granular form. Therefore, the results of this study open a clear trajectory for the clinical use of β-TCP putty in the reconstruction of the alveolar cleft and other challenging two-wall bony defects.
authors.forename: Nard G
authors.initials: NG
authors.lastname: Janssen
authors.forename: Adrianus P
authors.initials: AP
authors.lastname: de Ruiter
authors.forename: Wouter M M T
authors.initials: WMMT
authors.lastname: van Hout
authors.forename: Vincent
authors.initials: V
authors.lastname: van Miegem
authors.forename: Debby
authors.initials: D
authors.lastname: Gawlitta
authors.forename: Florence Barrère-de
authors.initials: FB
authors.lastname: Groot
authors.forename: Gert J
authors.initials: GJ
authors.lastname: Meijer
authors.forename: Antoine J W P
authors.initials: AJWP
authors.lastname: Rosenberg
authors.forename: Ronald
authors.initials: R
authors.lastname: Koole
mesh_terms: D000539:Alveolar Process / Q000601:surgery*; D000818:Animals; D018786:Bone Substitutes / Q000494:pharmacology*; D016025:Bone Transplantation / Q000379:methods*; D002130:Calcium Phosphates / Q000494:pharmacology*; D004195:Disease Models, Animal; D006041:Goats; D014182:Transplantation, Autologous; D055114:X-Ray Microtomography
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate
keywords: alveolar cleft; bone regeneration; calcium phosphate ceramic; goat model; osteoinduction; β-TCP