title: Spatiotemporal Dynamics of Dexmedetomidine-Induced Electroencephalogram Oscillations.
abstract: An improved understanding of the neural correlates of altered arousal states is fundamental for precise brain state targeting in clinical settings. More specifically, electroencephalogram recordings are now increasingly being used to relate drug-specific oscillatory dynamics to clinically desired altered arousal states. Dexmedetomidine is an anesthetic adjunct typically administered in operating rooms and intensive care units to produce and maintain a sedative brain state. However, a high-density electroencephalogram characterization of the neural correlates of the dexmedetomidine-induced altered arousal state has not been previously accomplished. Therefore, we administered dexmedetomidine (1mcg/kg bolus over 10 minutes, followed by 0.7mcg/kg/hr over 50 minutes) and recorded high-density electroencephalogram signals in healthy volunteers, 18-36 years old (n = 8). We analyzed the data with multitaper spectral and global coherence methods. We found that dexmedetomidine was associated with increased slow-delta oscillations across the entire scalp, increased theta oscillations in occipital regions, increased spindle oscillations in frontal regions, and decreased beta oscillations across the entire scalp. The theta and spindle oscillations were globally coherent. During recovery from this state, these electroencephalogram signatures reverted towards baseline signatures. We report that dexmedetomidine-induced electroencephalogram signatures more closely approximate the human sleep onset process than previously appreciated. We suggest that these signatures may be targeted by real time visualization of the electroencephalogram or spectrogram in clinical settings. Additionally, these signatures may aid the development of control systems for principled neurophysiological based brain-state targeting.
authors.affiliation: Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America.
authors.forename: Oluwaseun
authors.identifier: http://orcid.org/0000-0002-6740-1250
authors.initials: O
authors.lastname: Akeju
authors.affiliation: Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, United States of America.
authors.forename: Seong-Eun
authors.initials: SE
authors.lastname: Kim
authors.affiliation: Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America.
authors.forename: Rafael
authors.initials: R
authors.lastname: Vazquez
authors.affiliation: Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America.
authors.forename: James
authors.initials: J
authors.lastname: Rhee
authors.affiliation: Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America.
authors.forename: Kara J
authors.initials: KJ
authors.lastname: Pavone
authors.affiliation: Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America.
authors.forename: Lauren E
authors.initials: LE
authors.lastname: Hobbs
authors.affiliation: Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America.
authors.forename: Patrick L
authors.initials: PL
authors.lastname: Purdon
authors.affiliation: Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America.|Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, United States of America.
authors.forename: Emery N
authors.initials: EN
authors.lastname: Brown
mesh_terms: D000328:Adult; D001921:Brain / Q000187:drug effects / Q000502:physiology; D020927:Dexmedetomidine / Q000494:pharmacology*; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D062211:Spatio-Temporal Analysis; D055815:Young Adult
chemical_list: D020927:Dexmedetomidine