title: Continued Sensitivity ofPlasmodium falciparumto Artemisinin in Guyana, With Absence of Kelch Propeller Domain Mutant Alleles.
abstract: Because of concerns about possible emergence of artemisinin resistance strains ofPlasmodium falciparumin mining areas of the interior of Guyana, a 7-day artesunate trial was conducted from March to December 2014. The day-3 parasite clearance rate, the efficacy of artesunate at day 28, and polymorphism of Kelch 13 (PfK13)-the marker of artemisinin resistance-were assessed. The study confirmed the continued sensitivity ofP falciparumto artemisinin. A 7-day course of artesunate was 100% efficacious with only 2% (95% confidence interval, .1%-10.9%) of enrolled subjects positive at day 3. All day-0 parasite samples were wild type. Continued resistance monitoring is nevertheless recommended, given the widespread availability and uncontrolled use of artemisinin drugs in mining areas of Guyana.
authors.affiliation: Ministry of Public Health.
authors.forename: Reyaud
authors.initials: R
authors.lastname: Rahman
authors.affiliation: Pan American Health Organization , Georgetown , Guyana.
authors.forename: Maria Jesus Sanchez
authors.initials: MJ
authors.lastname: Martin
authors.affiliation: Ministry of Public Health.
authors.forename: Shamdeo
authors.initials: S
authors.lastname: Persaud
authors.affiliation: Pan American Health Organization , Georgetown , Guyana.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Ceron
authors.affiliation: Ministry of Public Health.
authors.forename: Dwayne
authors.initials: D
authors.lastname: Kellman
authors.affiliation: Laboratoire de Parasitologie , Institut Pasteur de la Guyane , Cayenne , French Guiana.
authors.forename: Lise
authors.initials: L
authors.lastname: Musset
authors.affiliation: Pan American Health Organization , Washington, District of Columbia.
authors.forename: Keith H
authors.initials: KH
authors.lastname: Carter
authors.affiliation: World Health Organization , Geneva , Switzerland.
authors.forename: Pascal
authors.initials: P
authors.lastname: Ringwald
keywords: C580Y; Kelch propeller domain; Plasmodium falciparum; artemisinin; malaria