title: Catalytic Direct C2-Alkenylation of Oxazoles at Parts per Million Levels of Palladium/PhMezole-Phos Complex.
abstract: General direct C2-alkenylation of oxazoles is reported using alkenyl tosylates at parts per million levels of palladium catalyst. From a series of ligands screened, PhMezole-Phos emerged as the promising ligand candidate to facilitate this reaction. Significantly, the method is scalable and exhibits excellent substrate tolerance. Highly sterically hindered substrates and small vinyl tosylate can be coupled successfully. Moreover, our method enables a rapid diversification of oxazole-based C^N ligands which can be readily derived into new group 9 organometallic compounds.
authors.affiliation: State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University , Hung Hom, Kowloon 852, Hong Kong.
authors.forename: Wai Chung
authors.initials: WC
authors.lastname: Fu
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072, Hubei, P.R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University , Hung Hom, Kowloon 852, Hong Kong.
authors.forename: Chau Ming
authors.initials: CM
authors.lastname: So
authors.affiliation: State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University , Hung Hom, Kowloon 852, Hong Kong.
authors.forename: Shun Man
authors.initials: SM
authors.lastname: Wong
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072, Hubei, P.R. China.
authors.forename: Aiwen
authors.initials: A
authors.lastname: Lei
authors.affiliation: State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University , Hung Hom, Kowloon 852, Hong Kong.
authors.forename: Fuk Yee
authors.initials: FY
authors.lastname: Kwong