title: Novel FeIIand CoIIComplexes of Natural Product Tryptanthrin: Synthesis and Binding with G-Quadruplex DNA.
abstract: Tryptanthrin is one of the most important members of indoloquinoline alkaloids. We obtained this alkaloid fromIsatis. Two novel FeIIand CoIIcomplexes of tryptanthrin were first synthesized. Single-crystal X-ray diffraction analyses show that these complexes display distorted four-coordinated tetrahedron geometry via two heterocyclic nitrogen and oxygen atoms from tryptanthrin ligand. Binding with G-quadruplex DNA properties revealed that both complexes were found to exhibit significant interaction with G-quadruplex DNA. This study may potentially serve as the basis of future rational design of metal-based drugs from natural products that target the G-quadruplex DNA.
authors.affiliation: College of Pharmacy of Guangxi University of Chinese Medicine, Nanning, Guangxi 530299, China.
authors.forename: Yi-Ning
authors.initials: YN
authors.lastname: Zhong
authors.affiliation: College of Pharmacy of Guangxi University of Chinese Medicine, Nanning, Guangxi 530299, China; Guangxi Key Laboratory for Agricultural Resources Chemistry and Efficient Utilization (Cultivation Base), Yulin Normal University, Yulin, Guangxi 537000, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Guangxi Key Laboratory for Agricultural Resources Chemistry and Efficient Utilization (Cultivation Base), Yulin Normal University, Yulin, Guangxi 537000, China; The Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin, Guangxi 541004, China.
authors.forename: Yun-Qiong
authors.initials: YQ
authors.lastname: Gu
authors.affiliation: College of Pharmacy of Guangxi University of Chinese Medicine, Nanning, Guangxi 530299, China.
authors.forename: Shi-Yun
authors.initials: SY
authors.lastname: Wu
authors.affiliation: Guangxi Key Laboratory for Agricultural Resources Chemistry and Efficient Utilization (Cultivation Base), Yulin Normal University, Yulin, Guangxi 537000, China.
authors.forename: Wen-Ying
authors.initials: WY
authors.lastname: Shen
authors.affiliation: College of Pharmacy of Guangxi University of Chinese Medicine, Nanning, Guangxi 530299, China; Guangxi Key Laboratory for Agricultural Resources Chemistry and Efficient Utilization (Cultivation Base), Yulin Normal University, Yulin, Guangxi 537000, China; The Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin, Guangxi 541004, China.
authors.forename: Ming-Xiong
authors.identifier: 0000-0002-7474-6281
authors.initials: MX
authors.lastname: Tan