title: Inflammatory Myofibroblastic Tumor of the Urinary Bladder: A Case Report.
abstract: An inflammatory myofibroblastic tumor (IMT) is a distinctive neoplasm composed of myofibroblastic and fibroblastic spindle cells, accompanied by inflammatory infiltration of plasma cells, lymphocytes, and eosinophils. IMTs rarely occur in the urinary bladder. It is important to distinguish this tumor from other malignant spindle cell tumors. Herein, we report a patient with an IMT showing muscle invasion, who underwent a transurethral resection of the bladder tumor and, at a later date, partial cystectomy. The resected tumor specimen revealed a proliferation of spindle-shaped cells on a background of plasma cells and lymphocytes. Immunohistochemical staining showed the tumor to be positive for anaplastic lymphoma kinase (ALK), smooth muscle actin, and vascular endothelial growth factor (VEGF). Such histopathological findings were indicative of an IMT, suggesting the use of inhibitors of ALK and VEGF as pharmacotherapy.
authors.affiliation: Department of Urology, JA Mie Komono Kosei Hospital, Komono, Japan; Department of Nephro-urology, Nagoya City University, Graduate School of Medical Sciences, Nagoya City, Japan.
authors.forename: Toshiki
authors.initials: T
authors.lastname: Etani
authors.affiliation: Department of Nephro-urology, Nagoya City University, Graduate School of Medical Sciences, Nagoya City, Japan.
authors.forename: Taku
authors.initials: T
authors.lastname: Naiki
authors.affiliation: Department of Nephro-urology, Nagoya City University, Graduate School of Medical Sciences, Nagoya City, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nagai
authors.affiliation: Department of Nephro-urology, Nagoya City University, Graduate School of Medical Sciences, Nagoya City, Japan.
authors.forename: Keitaro
authors.initials: K
authors.lastname: Iida
authors.affiliation: Department of Nephro-urology, Nagoya City University, Graduate School of Medical Sciences, Nagoya City, Japan.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Ando
authors.affiliation: Department of Experimental Pathology and Tumor Biology, Nagoya City University, Graduate School of Medical Sciences, Nagoya City, Japan.
authors.forename: Aya
authors.initials: A
authors.lastname: Naiki-Ito
authors.affiliation: Department of Nephro-urology, Nagoya City University, Graduate School of Medical Sciences, Nagoya City, Japan.
authors.forename: Noriyasu
authors.initials: N
authors.lastname: Kawai
authors.affiliation: Department of Nephro-urology, Nagoya City University, Graduate School of Medical Sciences, Nagoya City, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Tozawa
authors.affiliation: Department of Nephro-urology, Nagoya City University, Graduate School of Medical Sciences, Nagoya City, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Mizuno
authors.affiliation: Department of Nephro-urology, Nagoya City University, Graduate School of Medical Sciences, Nagoya City, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Okada
authors.affiliation: Department of Urology, JA Mie Komono Kosei Hospital, Komono, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Mogami
authors.affiliation: Department of Nephro-urology, Nagoya City University, Graduate School of Medical Sciences, Nagoya City, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yasui
keywords: Anaplastic lymphoma kinase; Bladder; Inflammatory myofibroblastic tumor; Vascular endothelial growth factor