title: Advances in Molecular Imaging Strategies forIn VivoTracking of Immune Cells.
abstract: Tracking of immune cellsin vivois a crucial tool for development and optimization of cell-based therapy. Techniques for tracking immune cells have been applied widely for understanding the intrinsic behavior of immune cells and include non-radiation-based techniques such as optical imaging and magnetic resonance imaging (MRI), radiation-based techniques such as computerized tomography (CT), and nuclear imaging including single photon emission computerized tomography (SPECT) and positron emission tomography (PET). Each modality has its own strengths and limitations. To overcome the limitations of each modality, multimodal imaging techniques involving two or more imaging modalities are actively applied. Multimodal techniques allow integration of the strengths of individual modalities. In this review, we discuss the strengths and limitations of currently available preclinicalin vivoimmune cell tracking techniques and summarize the value of immune cell tracking in the development and optimization of immune cell therapy for various diseases.
authors.affiliation: Department of Nuclear Medicine, Kyungpook National University School of Medicine and Hospital, Daegu, Republic of Korea.
authors.forename: Ho Won
authors.initials: HW
authors.lastname: Lee
authors.affiliation: Department of Nuclear Medicine, Kyungpook National University School of Medicine and Hospital, Daegu, Republic of Korea.
authors.forename: Prakash
authors.initials: P
authors.lastname: Gangadaran
authors.affiliation: Department of Nuclear Medicine, Kyungpook National University School of Medicine and Hospital, Daegu, Republic of Korea.
authors.forename: Senthilkumar
authors.identifier: 0000-0003-4692-5917
authors.initials: S
authors.lastname: Kalimuthu
authors.affiliation: Department of Nuclear Medicine, Kyungpook National University School of Medicine and Hospital, Daegu, Republic of Korea.
authors.forename: Byeong-Cheol
authors.identifier: 0000-0001-7700-3929
authors.initials: BC
authors.lastname: Ahn
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology / Q000648:ultrastructure; D058948:Cell Tracking / Q000379:methods; D003713:Dendritic Cells / Q000276:immunology / Q000648:ultrastructure; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology / Q000648:ultrastructure; D008264:Macrophages / Q000276:immunology / Q000648:ultrastructure; D008279:Magnetic Resonance Imaging / Q000379:methods*; D057054:Molecular Imaging / Q000379:methods*; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*; D000072098:Single Photon Emission Computed Tomography Computed Tomography / Q000379:methods*; D013601:T-Lymphocytes / Q000276:immunology / Q000648:ultrastructure