title: Numerical Investigation of Flow Characteristics in the Obstructed Realistic Human Upper Airway.
abstract: The flow characteristics in the realistic human upper airway (HUA) with obstruction that resulted from pharyngeal collapse were numerically investigated. The 3D anatomically accurate HUA model was reconstructed from CT-scan images of a Chinese male patient (38 years, BMI 25.7). The computational fluid dynamics (CFD) with the large eddy simulation (LES) method was applied to simulate the airflow dynamics within the HUA model in both inspiration and expiration processes. The laser Doppler anemometry (LDA) technique was simultaneously adopted to measure the airflow fields in the HUA model for the purpose of testifying the reliability of LES approach. In the simulations, the representative respiration intensities of 16.8 L/min (slight breathing), 30 L/min (moderate breathing), and 60 L/min (severe breathing) were conducted under continuous inspiration and expiration conditions. The airflow velocity field and static pressure field were obtained and discussed in detail. The results indicated the airflow experiences unsteady transitional/turbulent flow in the HUA model under low Reynolds number. The airflow fields cause occurrence of forceful injection phenomenon due to the narrowing of pharynx caused by the respiratory illness in inspiration and expiration. There also exist strong flow separation and back flow inside obstructed HUA owing to the vigorous jet flow effect in the pharynx. The present results would provide theoretical guidance for the treatment of obstructive respiratory disease.
authors.affiliation: College of Metrology and Measurement Engineering, China Jiliang University, Hangzhou, China.
authors.forename: Xingli
authors.initials: X
authors.lastname: Liu
authors.affiliation: College of Metrology and Measurement Engineering, China Jiliang University, Hangzhou, China.
authors.forename: Weiwei
authors.identifier: 0000-0002-8640-6700
authors.initials: W
authors.lastname: Yan
authors.affiliation: Department of Mechanical Engineering, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Mechanical Engineering, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
authors.forename: Yat Sze
authors.initials: YS
authors.lastname: Choy
authors.affiliation: Faculty of Mechanical Engineering and Automation, Zhejiang Sci-Tech University, Hangzhou, China.
authors.forename: Yikun
authors.initials: Y
authors.lastname: Wei
mesh_terms: D000328:Adult; D000402:Airway Obstruction / Q000000981:diagnostic imaging / Q000503:physiopathology*; D044466:Asian People; D001696:Biomechanical Phenomena; D002681:China; D003198:Computer Simulation; D006801:Humans; D007830:Larynx / Q000503:physiopathology; D008168:Lung / Q000000981:diagnostic imaging; D008297:Male; D015233:Models, Statistical; D008962:Models, Theoretical; D009055:Mouth / Q000503:physiopathology; D009296:Nasal Cavity / Q000503:physiopathology; D010614:Pharynx / Q000503:physiopathology; D012119:Respiration; D012120:Respiration Disorders / Q000000981:diagnostic imaging* / Q000503:physiopathology; D015656:Respiratory Mechanics; D012137:Respiratory System / Q000503:physiopathology*; D014057:Tomography, X-Ray Computed; D014132:Trachea / Q000503:physiopathology