title: An efficient approach to selective electromembrane extraction of naproxen by means of molecularly imprinted polymer-coated multi-walled carbon nanotubes-reinforced hollow fibers.
abstract: In this work, a novel microextraction technique using molecularly imprinted polymer-coated multi-walled carbon nanotubes (MIP-MWCNTs) in electromembrane extraction (EME) procedure is described. The method in combination with HPLC-UV was utilized to determine naproxen, as an acidic model drug, in urine, plasma and wastewater samples. For this purpose, MIP-MWCNTs were placed in the pores of polypropylene hollow fiber. The MIP-MWCNTs-EME method has the advantages of high selectivity and cleanup of MIP along with high enrichment ability of the EME in a single step extraction. Continuing with the research, optimization of the factors affecting the migration of naproxen from sample solutions to MIP-MWCNTs sites and then into the lumen of hollow fiber was explored. Under the optimized conditions, the limit of detection (LOD) of the developed method was calculated to be 0.3μgL-1. All relative standard deviations (RSDs) were lower than 3%. Linearity of the method was obtained within the range of 1-1000μgL-1with the coefficient of determination (r2) being higher than 0.999. Under the optimized conditions, an extraction recovery of 66% was obtained, which corresponded to a preconcentration factor of 88. Finally, the developed method was satisfactorily used to determine naproxen in urine, plasma and wastewater samples.
authors.affiliation: Faculty of Chemistry, Shahid Beheshti University, G. C., 1983963113, Evin, Tehran, Iran.
authors.forename: Zeinab
authors.initials: Z
authors.lastname: Tahmasebi
authors.affiliation: Faculty of Chemistry, Shahid Beheshti University, G. C., 1983963113, Evin, Tehran, Iran. Electronic address: ss-hosseiny@sbu.ac.ir.
authors.forename: Saied Saeed Hosseiny
authors.initials: SS
authors.lastname: Davarani
authors.affiliation: Faculty of Chemistry, Shahid Beheshti University, G. C., 1983963113, Evin, Tehran, Iran.
authors.forename: Ali Akbar
authors.initials: AA
authors.lastname: Asgharinezhad
mesh_terms: D004560:Electricity; D057230:Limit of Detection; D059627:Liquid Phase Microextraction / Q000379:methods*; D054802:Molecular Imprinting; D037742:Nanotubes, Carbon; D009288:Naproxen / Q000097:blood / Q000302:isolation & purification* / Q000652:urine; D011108:Polymers / Q000138:chemical synthesis; D011126:Polypropylenes; D062065:Wastewater / Q000737:chemistry; D014874:Water Pollutants, Chemical / Q000302:isolation & purification
chemical_list: D037742:Nanotubes, Carbon; D009288:Naproxen; D011108:Polymers; D011126:Polypropylenes; D062065:Wastewater; D014874:Water Pollutants, Chemical
keywords: Electromembrane extraction; Molecularly imprinted polymer coated multiwalled carbon nanotubes; Naproxen; Plasma and urine samples; Selective extraction