title: Amygdala-based intrinsic functional connectivity and anxiety disorders in adolescents and young adults.
abstract: Anxiety disorders (AD) are the most prevalent group of psychiatric disorders in adolescents and young adults. Nevertheless, the pathophysiology of anxiety disorders is still poorly understood. This study investigated differences in the functional connectivity of intrinsic amygdala-based networks of participants with and without AD. Resting state fMRI data were obtained from 18 participants with an AD and 19 healthy comparison individuals. Psychiatric diagnosis was assessed using standardized structured interviews. The comparison between groups was carried out using functional connectivity maps from six seed regions defined using probabilistic maps bilaterally within the amygdala (basolateral, superficial and centromedial amygdala). We found significant between-group differences in five clusters, which showed aberrant functional connectivity with the left basolateral amygdala: right precentral gyrus, right cingulate gyrus, bilateral precuneus, and right superior frontal gyrus in subjects with AD as compared with the comparison subjects. For the comparison subjects, the correlations between the amygdala and the five clusters were either non-significant, or negative. The present study suggests there is an intrinsic disruption in the communication between left basolateral amygdala and a network of brain regions involved with emotion regulation, and with the default mode network in adolescents and young adults with anxiety disorders.
authors.affiliation: Anxiety Disorders Program for Child and Adolescent Psychiatry (PROTAIA), Hospital de Clínicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil; Postgraduate Program in Neuroscience, Institute of Basic Sciences/Health (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. Electronic address: rudineiatoazza@gmail.com.
authors.forename: Rudineia
authors.initials: R
authors.lastname: Toazza
authors.affiliation: PUCRS, Brain Institute of Rio Grande do Sul (BraIns), Porto Alegre, RS, Brazil; PUCRS, Postgraduate Program in Medicine and Health Science, Neuroscience, Porto Alegre, RS, Brazil; PUCRS, Postgraduate Program in Electrical Engineering, Biomedical Engineering, Porto Alegre, RS, Brazil.
authors.forename: Alexandre Rosa
authors.initials: AR
authors.lastname: Franco
authors.affiliation: PUCRS, Brain Institute of Rio Grande do Sul (BraIns), Porto Alegre, RS, Brazil; PUCRS, Postgraduate Program in Electrical Engineering, Biomedical Engineering, Porto Alegre, RS, Brazil.
authors.forename: Augusto
authors.initials: A
authors.lastname: Buchweitz
authors.affiliation: Postgraduate Program in Child and Adolescent Health, Hospital de Clínicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul, Brazil.
authors.forename: Roberta Dalle
authors.initials: RD
authors.lastname: Molle
authors.affiliation: Anxiety Disorders Program for Child and Adolescent Psychiatry (PROTAIA), Hospital de Clínicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil; Postgraduate Program in Neuroscience, Institute of Basic Sciences/Health (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
authors.forename: Danitsa Marcos
authors.initials: DM
authors.lastname: Rodrigues
authors.affiliation: Postgraduate Program in Child and Adolescent Health, Hospital de Clínicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul, Brazil.
authors.forename: Roberta Sena
authors.initials: RS
authors.lastname: Reis
authors.affiliation: Anxiety Disorders Program for Child and Adolescent Psychiatry (PROTAIA), Hospital de Clínicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil; Postgraduate Program in Child and Adolescent Health, Hospital de Clínicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul, Brazil.
authors.forename: Amanda Brondani
authors.initials: AB
authors.lastname: Mucellini
authors.affiliation: PUCRS, Brain Institute of Rio Grande do Sul (BraIns), Porto Alegre, RS, Brazil; PUCRS, Postgraduate Program in Electrical Engineering, Biomedical Engineering, Porto Alegre, RS, Brazil.
authors.forename: Nathalia Bianchini
authors.initials: NB
authors.lastname: Esper
authors.affiliation: PUCRS, Brain Institute of Rio Grande do Sul (BraIns), Porto Alegre, RS, Brazil.
authors.forename: Cristiano
authors.initials: C
authors.lastname: Aguzzoli
authors.affiliation: Postgraduate Program in Neuroscience, Institute of Basic Sciences/Health (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil; Postgraduate Program in Child and Adolescent Health, Hospital de Clínicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul, Brazil.
authors.forename: Patrícia Pelufo
authors.initials: PP
authors.lastname: Silveira
authors.affiliation: Anxiety Disorders Program for Child and Adolescent Psychiatry (PROTAIA), Hospital de Clínicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil; Postgraduate Program in Medical Sciences: Psychiatry, Hospital de Clínicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
authors.forename: Giovanni Abrahão
authors.initials: GA
authors.lastname: Salum
authors.affiliation: Anxiety Disorders Program for Child and Adolescent Psychiatry (PROTAIA), Hospital de Clínicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil; Postgraduate Program in Neuroscience, Institute of Basic Sciences/Health (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil; Postgraduate Program in Medical Sciences: Psychiatry, Hospital de Clínicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
authors.forename: Gisele Gus
authors.initials: GG
authors.lastname: Manfro
mesh_terms: D000293:Adolescent; D000679:Amygdala / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001008:Anxiety Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004644:Emotions; D005260:Female; D059907:Functional Neuroimaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000000981:diagnostic imaging / Q000503:physiopathology*; D055815:Young Adult
keywords: Cognitive neuroscience; FMRI; Probabilistic maps; Psychiatry disorders