title: Interfacial properties of POPC/GDO liquid crystalline nanoparticles deposited on anionic and cationic silica surfaces.
abstract: Reversed lipid liquid crystalline nanoparticles (LCNPs) of the cubic micellar (I2) phase have high potential in drug delivery applications due to their ability to encapsulate both hydrophobic and hydrophilic drug molecules. Their interactions with various interfaces, and the consequences for the particle structure and integrity, are essential considerations in their effectiveness as drug delivery vehicles. Here, we have studied LCNPs formed of equal fractions of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine and glycerol dioleate in the presence of different fractions of the stabilizer Polysorbate 80. We have used a combination of ellipsometry, quartz crystal microbalance with dissipation monitoring and neutron reflectometry to reveal the structure and composition of the adsorbed layer on both anionic silica and cationic (aminopropyltriethoxysilane) silanized surfaces. For both types of surfaces, there is a spread near-surface layer comprising lipid and polymer as well as a sparse coverage of intact particles. The composition of the near-surface layer is very close to that of the particles, in contrast to the lipid bilayer observed with related systems. The interaction is stronger for cationic than anionic surfaces, which is rationalized in terms of the negative zeta potential of the LCNPs. The work shows that the attachment of and spreading from LCNPs is influenced by the properties of the surface, the internal structure, composition and stability of the particles as well as the nature of the stabilizer.
authors.affiliation: Physical Chemistry, Department of Chemistry, Lund University, P. O. Box 124, SE-221 Lund, Sweden. Tommy.Nylander@fkem1.lu.se.
authors.forename: Debby P
authors.initials: DP
authors.lastname: Chang
authors.affiliation: Physical Chemistry, Department of Chemistry, Lund University, P. O. Box 124, SE-221 Lund, Sweden. Tommy.Nylander@fkem1.lu.se.
authors.forename: Aleksandra P
authors.initials: AP
authors.lastname: Dabkowska
authors.affiliation: Institut Laue-Langevin, 71, avenue des Martyrs, BP 156, 38042 Grenoble Cedex 9, France.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Campbell
authors.affiliation: Physical Chemistry, Department of Chemistry, Lund University, P. O. Box 124, SE-221 Lund, Sweden. Tommy.Nylander@fkem1.lu.se.
authors.forename: Maria
authors.initials: M
authors.lastname: Wadsäter
authors.affiliation: Camurus AB, Ideon Science Park, Gamma Building, Sölvegatan 41, SE-22379 Lund, Sweden and Biomedical Science, Faculty of Health and Society, Malmö University, SE-20506 Malmö, Sweden.
authors.forename: Justas
authors.initials: J
authors.lastname: Barauskas
authors.affiliation: Camurus AB, Ideon Science Park, Gamma Building, Sölvegatan 41, SE-22379 Lund, Sweden.
authors.forename: Fredrik
authors.initials: F
authors.lastname: Tiberg
authors.affiliation: Physical Chemistry, Department of Chemistry, Lund University, P. O. Box 124, SE-221 Lund, Sweden. Tommy.Nylander@fkem1.lu.se.
authors.forename: Tommy
authors.initials: T
authors.lastname: Nylander