title: Venous Thromboembolism - Current Diagnostic and Treatment Modalities.
abstract: BACKGROUND
  Pulmonary embolism and deep venous thrombosis, known as venous thromboembolism (VTE), are associated with a high proportion of morbidity and mortality.
  
  
  OBJECTIVE
  Aim of this review is to emphasise current diagnostic and therapeutic modalities for VTE.
  
  
  RESULTS
  No differences have been noticed in European and American guidelines in diagnostic approach of this disorder. Today there is enough clinical information for the use of heparin (either, unfractionated or low molecular) and vitamin K antagonists in the treatment of acute and chronic phases of VTE. Novel oral anticoagulants seem to have some advantages in the treatment of this disorder. Rivaroxaban has been approved widespread, for use as a single-drug approach of VTE.
  
  
  CONCLUSIONS
  Both guidelines are almost similar and good basis for evidence-based treatment of this disorder.
authors.affiliation: University Cardiology Clinic, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
authors.forename: Marijan
authors.initials: M
authors.lastname: Bosevski
authors.affiliation: University Cardiology Clinic, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
authors.forename: Elizabeta
authors.initials: E
authors.lastname: Srbinovska-Kostovska
keywords: deep venous thrombosis treatment; novel oral anticoagulants; pulmonary embolism; venous thromboembolism