title: Association of IL-1α gene polymorphism with susceptibility to type 1 diabetes in Chinese children.
abstract: The interleukin-1α (IL-1α) gene appears to play a role in the pathogenesis of type 1 diabetes (T1D). Therefore, the aim of this study was to investigate the contribution of the IL-1 rs1800587 gene polymorphism to susceptibility to T1D in Chinese children. This case-control study included 332 Chinese children with T1D and 332 healthy controls. Identification of genetic variants of rs1800587 in the IL-1α gene was performed by polymerase chain reaction amplification. The IL-1α rs1800587 polymorphism demonstrated a significant association with T1D risk. The allelic frequency significantly differed between the T1D and control groups [odds ratio (OR) = 0.7; 95% confidence interval (CI) = 0.52-0.86; P = 0.002]. Furthermore, significant differences were observed in the dominant model (CC/CT + TT; OR = 0.6; 95%CI = 0.46-0.85; P = 0.003). In T1D patients, the prevalence of hypertension in T allele carriers was 4.2-fold higher than that in C allele carriers, (95%CI = 2.67-6.58; P < 0.001). In conclusion, the present study found evidence of a significant association between the rs1800587 polymorphism in the IL-1α gene and T1D.
authors.affiliation: Department of Pediatrics, Jinan Central Hospital Affiliated to Shandong University, Jinan, China.
authors.forename: X
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, Jingshi, Jinan, China.
authors.forename: J G
authors.initials: JG
authors.lastname: Ca
authors.affiliation: Department of Pediatrics, Jinan Central Hospital Affiliated to Shandong University, Jinan, China.
authors.forename: H
authors.initials: H
authors.lastname: Peng
authors.affiliation: Department of Pediatrics, Jinan Central Hospital Affiliated to Shandong University, Jinan, China.
authors.forename: J L
authors.initials: JL
authors.lastname: Wang
authors.affiliation: Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, Jingshi, Jinan, China hpengjnsd@163.com.
authors.forename: G M
authors.initials: GM
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D053582:Interleukin-1alpha / Q000235:genetics*; D008297:Male; D008957:Models, Genetic; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: C508584:IL1A protein, human; D053582:Interleukin-1alpha