title: Vaccination Expectations in HNSCC.
abstract: HPV-associated head and neck squamous cell carcinoma (HNSCC), more specifically the incidence of oropharyngeal cancer, is dramatically increasing in industrialized countries. According to what has been learned from anogenital vaccination programs, there are reasons to believe that current human papillomavirus (HPV) vaccinations may be potentially effective also against HNSCC. However, before specific results on HNSCC are available, one must keep in mind that carcinogenesis in the head and neck region may differ from that of the anogenital tract. Furthermore, the current evidence supports the view that HPV infection is much more complex than simply a sexually transmitted disease. HPV is present in the semen, placenta and in the newborns, and these infections of the newborns create cell-mediated immunity (CMI) against HPV, including the T memory cells. Acquisition of HPV infection in early life will rise new series of questions in the field of HPV vaccination.
authors.affiliation: Department of Oral Pathology, Faculty of Medicine, Turku University Hospital, Institute of Dentistry, University of Turku, Lemminkäisenkatu 2, 20520, Turku, Finland. stina.syrjanen@utu.fi.
authors.forename: Stina
authors.initials: S
authors.lastname: Syrjänen
authors.affiliation: Department of Oral Pathology, Faculty of Medicine, Turku University Hospital, Institute of Dentistry, University of Turku, Lemminkäisenkatu 2, 20520, Turku, Finland.
authors.forename: Jaana
authors.initials: J
authors.lastname: Rautava
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000821:virology; D006258:Head and Neck Neoplasms / Q000276:immunology* / Q000821:virology; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D027383:Papillomaviridae / Q000276:immunology; D030361:Papillomavirus Infections / Q000276:immunology / Q000821:virology; D000077195:Squamous Cell Carcinoma of Head and Neck; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014611:Vaccination / Q000379:methods
keywords: Head and neck squamous cell carcinoma (HNSCC); Human papillomavirus (HPV); Vaccination