title: Evaluation of amorphous magnesium phosphate (AMP) based non-exothermic orthopedic cements.
abstract: This paper reports for the first time the development of a biodegradable, non-exothermic, self-setting orthopedic cement composition based on amorphous magnesium phosphate (AMP). The occurrence of undesirable exothermic reactions was avoided through using AMP as the solid precursor. The phenomenon of self-setting with optimum rheology is achieved by incorporating a water soluble biocompatible/biodegradable polymer, polyvinyl alcohol (PVA). Additionally, PVA enables a controlled growth of the final phase via a biomimetic process. The AMP powder was synthesized using a precipitation method. The powder, when in contact with the aqueous PVA solution, forms a putty resulting in a nanocrystalline magnesium phosphate phase of cattiite. The as-prepared cement compositions were evaluated for setting times, exothermicity, compressive strength, biodegradation, and microstructural features before and after soaking in SBF, and in vitro cytocompatibility. Since cattiite is relatively unexplored in the literature, a first time evaluation reveals that it is cytocompatible, just like the other phases in the MgO-P2O5(Mg-P) system. The cement composition prepared with 15% PVA in an aqueous medium achieved clinically relevant setting times, mechanical properties, and biodegradation. Simulated body fluid (SBF) soaking resulted in coating of bobierrite onto the cement particle surfaces.
authors.affiliation: Department of Bioengineering, University of Toledo, Toledo, OH 43606, USA.
authors.forename: Elham
authors.initials: E
authors.lastname: Babaie
authors.forename: Boren
authors.initials: B
authors.lastname: Lin
authors.forename: Vijay K
authors.initials: VK
authors.lastname: Goel
authors.forename: Sarit B
authors.initials: SB
authors.lastname: Bhaduri
mesh_terms: D016475:3T3 Cells; D000818:Animals; D001672:Biocompatible Materials; D032701:Biomimetics; D001826:Body Fluids / Q000737:chemistry; D001843:Bone Cements; D002470:Cell Survival; D019245:Compressive Strength; D003470:Culture Media; D000431:Ethanol / Q000737:chemistry; D017616:Magnesium Compounds / Q000737:chemistry*; D008277:Magnesium Oxide / Q000737:chemistry; D008422:Materials Testing; D051379:Mice; D009985:Orthopedics; D010006:Osteoblasts / Q000378:metabolism; D010710:Phosphates / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000737:chemistry; D011208:Powders; D012212:Rheology; D013314:Stress, Mechanical; D013499:Surface Properties; D013696:Temperature
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D003470:Culture Media; D017616:Magnesium Compounds; D010710:Phosphates; D011108:Polymers; D011208:Powders; D008277:Magnesium Oxide; D000431:Ethanol; C030781:magnesium phosphate; D011142:Polyvinyl Alcohol