title: Association between MASP-2 gene polymorphism and risk of infection diseases: A meta-analysis.
abstract: BACKGROUND
  The role of MASP-2 is vital in the process of complement activation by the lectin pathway. It is generally considered that the functional activation of MASP-2 contribute to the infection disease development process.
  
  
  OBJECTIVE
  To analyze the association between MASP-2 functional gene (rs72550870) polymorphism and the infection disease risk by a meta-analysis.
  
  
  METHODS
  Relevant case-control studies were identiﬁed by searching Cochrane Library, PubMed, Emabase, DOAJ, CAB Abstracts, CSA, CINAHL, EBSCO, Scopus, Global Health, Index Copernicus, CA, China National Knowledge Infrastructure (CNKI) databases up to 10th January 2016. The data were extracted and the methodological quality of studies were evaluated. The STATA 12.0 software was used to perform statistical analysis.
  
  
  RESULTS
  9 studies were included. There was no significant association between masp-2 gene (p.D120G, rs72550870) polymorphism and the risk of infection disease under the allele model (G vs. A: OR = 0.89, 95%CI = 0.66-1.21)(P = 0.445>0.05) and the recessive model (AG + GG vs.AA: OR = 0.88, 95%CI = 0.65-1.20) (P = 0.428>0.05).
  
  
  CONCLUSIONS
  This is the first comprehensive meta-analysis indicates that the MASP-2 functional gene (rs72550870) polymorphism is not associated with the infection diseases, and the key functional gene polymorphism of rs72550870 did not increase susceptibility to the infection diseases. Similarly, there were no obvious difference in subgroup analysis based on geographical areas and pathogenic microorganisms.
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China; National Hospital of Linxia City, Linxia, 731100, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Fu
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China.
authors.forename: Jingqiu
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China.
authors.forename: Lifeng
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China.
authors.forename: Xinfang
authors.initials: X
authors.lastname: Dong
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China.
authors.forename: Hongjuan
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China.
authors.forename: Mingqiang
authors.initials: M
authors.lastname: Cao
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China; Gansu Key Lab of Evidence Based Medicine and Clinical Transfer Medicine, Lanzhou University, Lanzhou, 730000, China. Electronic address: maxm@lzu.edu.cn.
authors.forename: Xingming
authors.initials: X
authors.lastname: Ma
mesh_terms: D002681:China; D003141:Communicable Diseases / Q000235:genetics* / Q000276:immunology*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007155:Immunologic Factors / Q000235:genetics*; D050606:Mannose-Binding Protein-Associated Serine Proteases / Q000235:genetics*; D011110:Polymorphism, Genetic; D018570:Risk Assessment
chemical_list: D007155:Immunologic Factors; C105296:MASP2 protein, human; D050606:Mannose-Binding Protein-Associated Serine Proteases
keywords: Complement; Infection diseases; MBL-Associated serine protease-2; Meta-analysis; Polymorphism