title: A cupric ion triggered DNA diode based on a tandem linkage-cleavage reaction.
abstract: Based on click chemistry and DNAzyme, we constructed for the first time a cupric ion triggered DNA diode using a tandem linkage-cleavage process, which could occur in order in a programmable and autonomous manner. This DNA diode is a new DNA functional element and can precisely control the translation direction of information.
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), MOE Key Laboratory of Bioorganic Chemistry and Molecular Engineering, College of Chemistry, Peking University, Beijing 100871, China. zhouyl@pku.edu.cn zxx@pku.edu.cn.
authors.forename: Ting
authors.initials: T
authors.lastname: Cao
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), MOE Key Laboratory of Bioorganic Chemistry and Molecular Engineering, College of Chemistry, Peking University, Beijing 100871, China. zhouyl@pku.edu.cn zxx@pku.edu.cn.
authors.forename: Ji
authors.initials: J
authors.lastname: Nie
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), MOE Key Laboratory of Bioorganic Chemistry and Molecular Engineering, College of Chemistry, Peking University, Beijing 100871, China. zhouyl@pku.edu.cn zxx@pku.edu.cn.
authors.forename: Liang-Yuan
authors.initials: LY
authors.lastname: Cai
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), MOE Key Laboratory of Bioorganic Chemistry and Molecular Engineering, College of Chemistry, Peking University, Beijing 100871, China. zhouyl@pku.edu.cn zxx@pku.edu.cn.
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Zhang
authors.affiliation: School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, UK and China Academy of Engineering Physics, Mianyang, 621900, Sichuan, China. zhangdewenpku@163.com.
authors.forename: De-Wen
authors.identifier: http://orcid.org/0000-0002-7665-2182
authors.initials: DW
authors.lastname: Zhang
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), MOE Key Laboratory of Bioorganic Chemistry and Molecular Engineering, College of Chemistry, Peking University, Beijing 100871, China. zhouyl@pku.edu.cn zxx@pku.edu.cn.
authors.forename: Ying-Lin
authors.initials: YL
authors.lastname: Zhou
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), MOE Key Laboratory of Bioorganic Chemistry and Molecular Engineering, College of Chemistry, Peking University, Beijing 100871, China. zhouyl@pku.edu.cn zxx@pku.edu.cn.
authors.forename: Xin-Xiang
authors.initials: XX
authors.lastname: Zhang
mesh_terms: D057930:Click Chemistry; D003300:Copper / Q000494:pharmacology*; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D021881:DNA, Catalytic / Q000378:metabolism*; D006801:Humans
chemical_list: D021881:DNA, Catalytic; D003300:Copper; D004247:DNA