title: Combined multi-modal photoacoustic tomography, optical coherence tomography (OCT) and OCT angiography system with an articulated probe forin vivohuman skin structure and vasculature imaging.
abstract: Cutaneous blood flow accounts for approximately 5% of cardiac output in human and plays a key role in a number of a physiological and pathological processes. We show for the first time a multi-modal photoacoustic tomography (PAT), optical coherence tomography (OCT) and OCT angiography system with an articulated probe to extract human cutaneous vasculaturein vivoin various skin regions. OCT angiography supplements the microvasculature which PAT alone is unable to provide. Co-registered volumes for vessel network is further embedded in the morphologic image provided by OCT. This multi-modal system is therefore demonstrated as a valuable tool for comprehensive non-invasive human skin vasculature and morphology imagingin vivo.
authors.affiliation: Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Währinger Gürtel 18-20, AKH 4L, Vienna, 1090, Austria.
authors.forename: Mengyang
authors.initials: M
authors.lastname: Liu
authors.affiliation: Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Währinger Gürtel 18-20, AKH 4L, Vienna, 1090, Austria.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Währinger Gürtel 18-20, AKH 4L, Vienna, 1090, Austria.
authors.forename: Behrooz
authors.initials: B
authors.lastname: Zabihian
authors.affiliation: Department of Dermatology, Medical University of Vienna, Währinger Gürtel 18-20, AKH 7J, Vienna, 1090, Austria.
authors.forename: Christoph
authors.initials: C
authors.lastname: Sinz
authors.affiliation: Department of Medical Physics and Biomedical Engineering, University College London, Gower Street, London, WC1E 6BT, UK.
authors.forename: Edward
authors.initials: E
authors.lastname: Zhang
authors.affiliation: Department of Medical Physics and Biomedical Engineering, University College London, Gower Street, London, WC1E 6BT, UK.
authors.forename: Paul C
authors.initials: PC
authors.lastname: Beard
authors.affiliation: Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Währinger Gürtel 18-20, AKH 4L, Vienna, 1090, Austria.
authors.forename: Laurin
authors.initials: L
authors.lastname: Ginner
authors.affiliation: INSIGHT Photonic Solutions, Inc., 300 S. Public Road, Lafayette, CO, 80026, USA.
authors.forename: Erich
authors.initials: E
authors.lastname: Hoover
authors.affiliation: INSIGHT Photonic Solutions, Inc., 300 S. Public Road, Lafayette, CO, 80026, USA.
authors.forename: Micheal P
authors.initials: MP
authors.lastname: Minneman
authors.affiliation: Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Währinger Gürtel 18-20, AKH 4L, Vienna, 1090, Austria.
authors.forename: Rainer A
authors.initials: RA
authors.lastname: Leitgeb
authors.affiliation: Department of Dermatology, Medical University of Vienna, Währinger Gürtel 18-20, AKH 7J, Vienna, 1090, Austria.
authors.forename: Harald
authors.initials: H
authors.lastname: Kittler
authors.affiliation: Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Währinger Gürtel 18-20, AKH 4L, Vienna, 1090, Austria.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Drexler
keywords: (170.0110) Imaging systems; (170.1610) Clinical applications; (170.1870) Dermatology; (170.3890) Medical optics instrumentation; (170.4500) Optical coherence tomography; (170.5120) Photoacoustic imaging