title: Children with atopic dermatitis in Daejeon, Korea: individualized nutrition intervention for disease severity and nutritional status.
abstract: OBJECTIVE
  Atopic dermatitis is one of the most common pediatric chronic inflammatory skin diseases, and certain food allergens and nutrients are closely related to the development and severity of atopic dermatitis. While avoidance of the causative foods is considered the mainstay of treatment, unverified excessive restriction might induce unnecessary limitations in the food intake, consequently leading to nutritional deficiencies and poor growth. This study aimed to identify the characteristics and nutrient intake status in children with atopic dermatitis and to investigate the effects of individualized nutrition intervention.
  
  
  METHODS
  We retrospectively reviewed electronic medical records of 77 pediatric patients with atopic dermatitis who received 4 months of individualized nutrition intervention combined with an elimination diet. The patient characteristics, nutrient intake status, and clinical status were examined before and after the intervention.
  
  
  RESULTS
  Before the intervention, 5 children had a weight for height z-score below -2.0, and 48.1% had experienced food restriction; these children showed a significantly higher SCORing of Atopic Dermatitis index than those without experiences, with the number of restricted foods before the intervention positively correlating with the disease severity. The intakes of n-6 and n-3 fatty acids, calcium, folate, and vitamin D were lower than the recommended nutrient intakes for Koreans. After the intervention, the weight for height z-score of 35 children was significantly increased and their SCORing of Atopic Dermatitis index was significantly reduced (p<0.05).
  
  
  CONCLUSIONS
  Individualized nutrition intervention appears useful for alleviating the severity of atopic dermatitis and improving the growth status by improving the nutrient intake.
authors.affiliation: Department of Food and Nutrition, Chungnam National University, Republic of Korea.
authors.forename: Seong Hee
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, College of Medicine, Chungnam National University, Republic of Korea.
authors.forename: Jae Ho
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Food and Nutrition, Chungnam National University, Republic of Korea. sunly@cnu.ac.kr.
authors.forename: Sun Yung
authors.initials: SY
authors.lastname: Ly
mesh_terms: D000293:Adolescent; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000178:diet therapy*; D005260:Female; D005512:Food Hypersensitivity / Q000178:diet therapy; D006801:Humans; D007223:Infant; D008297:Male; D044342:Malnutrition / Q000517:prevention & control; D044623:Nutrition Therapy / Q000379:methods*; D009751:Nutritional Requirements; D009752:Nutritional Status; D057285:Precision Medicine; D056910:Republic of Korea; D012189:Retrospective Studies