title: Role of actin in shaping autophagosomes.
abstract: One of the main unanswered questions regarding the early steps of macroautophagy/autophagy is the mechanism of membrane-modeling events required for autophagosome formation. Three independent studies have recently revealed an actin cytoskeleton involvement in this process, providing significant details regarding the role of actin in nucleation events both inside and outside the phagophore membrane during its expansion and assembly.
authors.affiliation: a Section of Molecular Biology, Division of Biological Sciences, University of California , San Diego, La Jolla , CA , USA.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Zientara-Rytter
authors.affiliation: a Section of Molecular Biology, Division of Biological Sciences, University of California , San Diego, La Jolla , CA , USA.
authors.forename: Suresh
authors.initials: S
authors.lastname: Subramani
mesh_terms: D000199:Actins / Q000378:metabolism*; D000818:Animals; D000071182:Autophagosomes / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008954:Models, Biological
chemical_list: D000199:Actins; D008869:Microtubule-Associated Proteins
keywords: CAPZ; JMY; WASL; WHAMM; actin; autophagosome shape; autophagy; nucleation-promoting factor