title: Cutaneous carcinosarcoma: a series of six cases and a review of the literature.
abstract: BACKGROUND
  Cutaneous carcinosarcoma is a rare tumor with distinct malignant epithelial and mesenchymal cell populations. The histologic subtypes of epithelial and mesenchymal components in cutaneous carcinosarcoma are variable, as an assortment of carcinomatous and sarcomatous patterns have been described in the literature.
  
  
  METHODS
  Clinical information was obtained from patient charts and archival slides were retrieved and reviewed.
  
  
  RESULTS
  We present a novel series of six distinct cases of cutaneous carcinosarcoma and review the literature. Our cases consisted of basal cell, pilomatrical, squamous cell, and trichoblastic variants. These cases occurred in elderly men on sun exposed skin with treatment and follow up was available for 4 of 6 cases. The four cases were treated with Mohs micrographic surgery with mean follow up of nine months.
  
  
  CONCLUSIONS
  We report six cases of cutaneous carcinosarcoma with distinctive clinical and histologic characterization not previously described in a single series.
authors.affiliation: Department of Dermatology, University of Utah, Salt Lake City, UT, USA.
authors.forename: Joshua J
authors.identifier: http://orcid.org/0000-0001-5304-3248
authors.initials: JJ
authors.lastname: Clark
authors.affiliation: Department of Dermatology, University of Utah, Salt Lake City, UT, USA.
authors.forename: Anneli R
authors.initials: AR
authors.lastname: Bowen
authors.affiliation: Department of Dermatology, University of Utah, Salt Lake City, UT, USA.|Department of Dermatology, Huntsman Cancer Institute, Salt Lake City, UT, USA.
authors.forename: Glen M
authors.initials: GM
authors.lastname: Bowen
authors.affiliation: Department of Surgery, University of Utah and Huntsman Cancer Institute, Salt Lake City, UT, USA.
authors.forename: John R
authors.initials: JR
authors.lastname: Hyngstrom
authors.affiliation: Department of Dermatology, University of Utah, Salt Lake City, UT, USA.
authors.forename: Michael L
authors.initials: ML
authors.lastname: Hadley
authors.affiliation: Department of Dermatology, University of Utah, Salt Lake City, UT, USA.
authors.forename: Keith
authors.initials: K
authors.lastname: Duffy
authors.affiliation: Department of Dermatology, University of Utah, Salt Lake City, UT, USA.
authors.forename: Scott R
authors.initials: SR
authors.lastname: Florell
authors.affiliation: Department of Dermatology, University of Utah, Salt Lake City, UT, USA.|Department of Dermatology, Huntsman Cancer Institute, Salt Lake City, UT, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Wada
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D002296:Carcinosarcoma / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D012878:Skin Neoplasms / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: carcinosarcoma; cutaneous carcinosarcoma; cutaneous neoplasm; dermatopathology; histopathology