title: PEG-mimetic peptoid reduces protein fouling of polysulfone hollow fibers.
abstract: Biofouling is a persistent problem for membranes exposed to blood or other complex biological fluids, affecting surface structure and hindering performance. In this study, a peptoid with 2-methoxyethyl (NMEG5) side chains was immobilized on polysulfone hollow fiber membranes to prevent protein fouling. The successful attachment of NMEG5 to the polysulfone surface was confirmed by X-ray photoelectron spectroscopy and an increase in hydrophilicity was confirmed by contact angle analysis. The NMEG5-modified surface was found to resist fouling with bovine serum albumin, lysozyme, and adsorbed significantly less fibrinogen as compared with other published low-fouling surfaces. Due to the low fouling nature and increased biocompatibility of the NMEG5 coated membranes, they have potential applicability in numerous biomedical applications including artificial lungs and hemodialysis.
authors.affiliation: Ralph E. Martin Department of Chemical Engineering, University of Arkansas, United States.
authors.forename: Neda
authors.initials: N
authors.lastname: Mahmoudi
authors.affiliation: Ralph E. Martin Department of Chemical Engineering, University of Arkansas, United States.
authors.forename: Lauren
authors.initials: L
authors.lastname: Reed
authors.affiliation: Ralph E. Martin Department of Chemical Engineering, University of Arkansas, United States.
authors.forename: Alex
authors.initials: A
authors.lastname: Moix
authors.affiliation: Cell and Molecular Biology, University of Arkansas, United States.
authors.forename: Nawaf
authors.initials: N
authors.lastname: Alshammari
authors.affiliation: Ralph E. Martin Department of Chemical Engineering, University of Arkansas, United States.
authors.forename: Jamie
authors.initials: J
authors.lastname: Hestekin
authors.affiliation: Ralph E. Martin Department of Chemical Engineering, University of Arkansas, United States. Electronic address: sservoss@uark.edu.
authors.forename: Shannon L
authors.initials: SL
authors.lastname: Servoss
mesh_terms: D000327:Adsorption / Q000187:drug effects; D000478:Alkylation; D057219:Biofouling / Q000517:prevention & control*; D005340:Fibrinogen / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D008567:Membranes, Artificial; D009113:Muramidase / Q000737:chemistry; D057786:Peptidomimetics / Q000138:chemical synthesis* / Q000494:pharmacology; D056951:Photoelectron Spectroscopy; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology; D012710:Serum Albumin, Bovine / Q000737:chemistry; D013450:Sulfones / Q000737:chemistry* / Q000494:pharmacology; D013499:Surface Properties
chemical_list: D008567:Membranes, Artificial; D057786:Peptidomimetics; D011108:Polymers; D013450:Sulfones; C017662:polysulfone P 1700; D012710:Serum Albumin, Bovine; D005340:Fibrinogen; D009113:Muramidase
keywords: Biocompatibility; Biofouling; Hollow fiber membrane; Peptoid; Polysulfone