title: Towards Dynamic Contrast Specific Ultrasound Tomography.
abstract: We report on the first study demonstrating the ability of a recently-developed, contrast-enhanced, ultrasound imaging method, referred to as cumulative phase delay imaging (CPDI), to image and quantify ultrasound contrast agent (UCA) kinetics. Unlike standard ultrasound tomography, which exploits changes in speed of sound and attenuation, CPDI is based on a marker specific to UCAs, thus enabling dynamic contrast-specific ultrasound tomography (DCS-UST). For breast imaging, DCS-UST will lead to a more practical, faster, and less operator-dependent imaging procedure compared to standard echo-contrast, while preserving accurate imaging of contrast kinetics. Moreover, a linear relation between CPD values and ultrasound second-harmonic intensity was measured (coefficient of determination = 0.87). DCS-UST can find clinical applications as a diagnostic method for breast cancer localization, adding important features to multi-parametric ultrasound tomography of the breast.
authors.affiliation: Biomedical Diagnostics Laboratory, Signal Processing Systems group, Faculty of Electrical Engineering, Eindhoven University of Technology, Eindhoven the Netherlands.
authors.forename: Libertario
authors.initials: L
authors.lastname: Demi
authors.affiliation: Biomedical Diagnostics Laboratory, Signal Processing Systems group, Faculty of Electrical Engineering, Eindhoven University of Technology, Eindhoven the Netherlands.
authors.forename: Ruud J G
authors.initials: RJ
authors.lastname: Van Sloun
authors.affiliation: Biomedical Diagnostics Laboratory, Signal Processing Systems group, Faculty of Electrical Engineering, Eindhoven University of Technology, Eindhoven the Netherlands.|Academic Medical Center Amsterdam, Amsterdam, the Netherlands.
authors.forename: Hessel
authors.initials: H
authors.lastname: Wijkstra
authors.affiliation: Biomedical Diagnostics Laboratory, Signal Processing Systems group, Faculty of Electrical Engineering, Eindhoven University of Technology, Eindhoven the Netherlands.
authors.forename: Massimo
authors.initials: M
authors.lastname: Mischi
mesh_terms: D001940:Breast / Q000000981:diagnostic imaging*; D003287:Contrast Media / Q000737:chemistry*; D005260:Female; D006801:Humans; D019047:Phantoms, Imaging; D014463:Ultrasonography / Q000295:instrumentation / Q000379:methods
chemical_list: D003287:Contrast Media