title: Long-Term Effect of Body Mass Index Changes on Graft Damage Markers in Patients After Kidney Transplantation.
abstract: BACKGROUND Both adiposity and underweight are negatively associated with graft and patient survival after kidney transplantation (KTx). The aim of this longitudinal study was to evaluate the changes in body mass index (BMI) after KTx and their relations with graft damage markers. MATERIAL AND METHODS The anthropometric measurements of body mass and height were performed in 92 consecutive deceased donor kidney transplant recipients (37 F; 55 M) from a single transplant center. Patient medical history, estimated glomerular filtration rate (eGFR), serum lipids, and ACR (urine albumin-to-creatinine ratio) was obtained from medical charts. RESULTS KTx recipients were on average 3.4±2.5 years after transplantation. Mean body BMI before KTx were 25.3±4.3 kg/m2 and increased after transplantation to 27.0±4.6 kg/m² (p=0.01). BMI increase after KTx was noted in 65% of recipients, most often in patients with normal pre-KTx BMI. Kidney function was better in patients with normal post-KTx BMI (55.2±15.8 ml/min/1.73 m²) than in obese patients (48.0±20.3 ml/min/1.73 m², p<0.05). Patients with normal post-KTx BMI had lower ACR (31.9±18.1 mg/g) than overweight (117.4±53.6 mg/g, p<0.05) and obese patients (280.0±81.7 mg/g, p<0.05). There were no differences in the mean BMI changes in recipients who received cyclosporine A or tacrolimus. CONCLUSIONS Patients after KTx showed an increase of BMI greater in those with normal pre-transplant body mass. The change in BMI over time has no effect on the graft function or magnitude of albuminuria. Overweight and obese patients after KTx have higher albuminuria and worse graft function than those with normal BMI. The type of calcineurin inhibitor has no effect on body mass after KTx.
authors.affiliation: Department of Clinical Pharmacology, 1st Chair of Internal Medicine, Medical University of Łódź, Łódź, Poland.
authors.forename: Ilona
authors.initials: I
authors.lastname: Kurnatowska
authors.affiliation: Department of Nephrology, Hypertension and Kidney Transplantation, Medical University of Łódź, Łódź, Poland.
authors.forename: Aneta
authors.initials: A
authors.lastname: Małyska
authors.affiliation: Department of Nephrology, Hypertension and Kidney Transplantation, Medical University of Łódź, Łódź, Poland.
authors.forename: Kamila
authors.initials: K
authors.lastname: Wysocka
authors.affiliation: Department of Nephrology, Hypertension and Kidney Transplantation, Medical University of Łódź, Łódź, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Mazur
authors.affiliation: Department of Nephrology, Hypertension and Kidney Transplantation, Medical University of Łódź, Łódź, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Krawczyk
authors.affiliation: Department of Nephrology, Hypertension and Kidney Transplantation, Medical University of Łódź, Łódź, Poland.
authors.forename: Michał
authors.initials: M
authors.lastname: Nowicki
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D005260:Female; D006085:Graft Survival; D006801:Humans; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000009:adverse effects*; D008055:Lipids / Q000097:blood; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000473:pathology; D050177:Overweight / Q000473:pathology; D013851:Thinness / Q000473:pathology
chemical_list: D008055:Lipids