title: Nanosizing a Metal-Organic Framework Enzyme Carrier for Accelerating Nerve Agent Hydrolysis.
abstract: We report the synthesis and characterization of a water-stable zirconium metal-organic framework (MOF), NU-1003, featuring the largest mesoporous aperture known for a zirconium MOF. This material has been used to immobilize the nerve agent hydrolyzing enzyme, organophosphorus acid anhydrolase (OPAA). The catalytic efficiency of immobilized OPAA in nanosized NU-1003 is significantly increased compared to that of OPAA immobilized in microsized NU-1003 and even exceeds that of the free OPAA enzyme. This paper highlights a method for rapid and highly efficient hydrolysis of nerve agents using nanosized enzyme carriers.
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.forename: Su-Young
authors.initials: SY
authors.lastname: Moon
authors.affiliation: U.S. Army Edgewood Chemical Biological Center , 5183 Blackhawk Road, RDCB-DRC-C, Aberdeen Proving Ground, Maryland 21010-5424, United States.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Guelta
authors.affiliation: State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology , Dalian 116024, People's Republic of China.
authors.forename: Lu
authors.initials: L
authors.lastname: Lin
authors.forename: Diego A
authors.initials: DA
authors.lastname: Gómez-Gualdrón
authors.forename: Randall Q
authors.initials: RQ
authors.lastname: Snurr
authors.affiliation: U.S. Army Edgewood Chemical Biological Center , 5183 Blackhawk Road, RDCB-DRC-C, Aberdeen Proving Ground, Maryland 21010-5424, United States.
authors.forename: Steven P
authors.initials: SP
authors.lastname: Harvey
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Hupp
authors.affiliation: Department of Chemistry, Faculty of Science, King Abdulaziz University , Jeddah 21589, Saudi Arabia.
authors.forename: Omar K
authors.initials: OK
authors.lastname: Farha
keywords: enzyme immobilization; metal−organic framework; nanocarrier; nerve agent catalysis