title: Effect of metformin on global gene expression in liver of KKAy mice.
abstract: BACKGROUND
  Metformin is a first-line drug for treating type 2 diabetes mellitus, yet its mechanism remains only partially understood and controversial. In this study we assessed a global gene expression profiling in liver of KKAy mice affected by metformin. This study aimed to identify the novel anti-diabetic mechanisms of metformin.
  
  
  METHODS
  After KKAy mice were administered metformin for 5 weeks, the gene changes profile in the livers of KKAy mice were assessed by using the Agilent whole mice genome oligo microarray.
  
  
  RESULTS
  Metformin altered the gene expression profiles in liver of KKAy mice. To our best knowledge, some genes have not been reported until now, such as Anxa2, Atf6, and so on. These genes were involved in many pathways, such as peroxisome proliferator activated receptor signaling pathway.
  
  
  CONCLUSIONS
  Gene expression changes induced by metformin were in support of the improvement of glucolipid metabolism and insulin resistance in KKAy mice. These findings expanded our knowledge of pharmacological action of metformin, and provided the potential novel insights and interesting information about the molecules involved in the antidiabetic effects of metformin.
authors.affiliation: College of Life Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding 071002, PR China; College of Pharmaceutical Science, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, PR China.
authors.forename: Zhi-Qin
authors.initials: ZQ
authors.lastname: Liu
authors.affiliation: College of Life Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding 071002, PR China.
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Song
authors.affiliation: Affiliated Hospital of Hebei University, Baoding 071002, PR China.
authors.forename: Que-Ting
authors.initials: QT
authors.lastname: Chen
authors.affiliation: College of Life Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding 071002, PR China.
authors.forename: Ting
authors.initials: T
authors.lastname: Liu
authors.affiliation: College of Life Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding 071002, PR China.
authors.forename: Ji-Tao
authors.initials: JT
authors.lastname: Teng
authors.affiliation: College of Life Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding 071002, PR China.
authors.forename: Kun
authors.initials: K
authors.lastname: Zhou
authors.affiliation: College of Life Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding 071002, PR China. Electronic address: duqiangluo999@126.com.
authors.forename: Du-Qiang
authors.initials: DQ
authors.lastname: Luo
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D020869:Gene Expression Profiling / Q000379:methods*; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008687:Metformin / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D008810:Mice, Inbred C57BL
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D008687:Metformin
keywords: Diabetes mellitus; Gene expression; Metformin