title: Sensory Responsiveness in Siblings of Children with Autism Spectrum Disorders.
abstract: This study examined sensory responsiveness in unaffected siblings of children with autism spectrum disorder (ASD) and associations between sensory responsiveness and social severity. Sensory Profile Caregiver Questionnaires and Social Responsiveness Scales were completed by parents of 185 children between age 4 and 10.95 years. Significant differences were found between participants with ASD and controls, and between participants with ASD and unaffected siblings for all sensory quadrants and domains, but not between controls and unaffected siblings. Social responsiveness scores were significantly correlated with scores from most sensory profile categories. Sensory responsiveness as an endophenotype of ASD is not indicated from these findings; however, studies with larger numbers of unaffected siblings and controls are needed to confirm the null hypothesis.
authors.affiliation: Department of Occupational Therapy and Division of Rehabilitation Science, School of Health Professions, University of Texas Medical Branch, 301 University Blvd., Galveston, TX, USA. clhilton@utmb.edu.|Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. clhilton@utmb.edu.|Program in Occupational Therapy, Washington University School of Medicine, St. Louis, MO, USA. clhilton@utmb.edu.|Occupational Therapy Department, Saint Louis University, St. Louis, USA. clhilton@utmb.edu.
authors.forename: Claudia L
authors.initials: CL
authors.lastname: Hilton
authors.affiliation: Play2Learn, Chesterfield, MO, USA.|Program in Occupational Therapy, Washington University School of Medicine, St. Louis, MO, USA.
authors.forename: Alison
authors.initials: A
authors.lastname: Babb-Keeble
authors.affiliation: Central Kansas Cooperative in Education, Salina, KS, USA.|Program in Occupational Therapy, Washington University School of Medicine, St. Louis, MO, USA.
authors.forename: Erin Eitzmann
authors.initials: EE
authors.lastname: Westover
authors.affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: San Diego Unified School District, San Diego, CA, USA.|Occupational Therapy Department, Saint Louis University, St. Louis, USA.
authors.forename: Claire
authors.initials: C
authors.lastname: Adams
authors.affiliation: Department of Occupational Therapy and Division of Rehabilitation Science, School of Health Professions, University of Texas Medical Branch, 301 University Blvd., Galveston, TX, USA.
authors.forename: Diane M
authors.initials: DM
authors.lastname: Collins
authors.affiliation: Division of Rehabilitation Science, University of Texas Medical Branch, Galveston, TX, USA.
authors.forename: Amol
authors.initials: A
authors.lastname: Karmarkar
authors.affiliation: Department of Occupational Therapy and Division of Rehabilitation Science, School of Health Professions, University of Texas Medical Branch, 301 University Blvd., Galveston, TX, USA.
authors.forename: Timothy A
authors.initials: TA
authors.lastname: Reistetter
authors.affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
authors.forename: John N
authors.initials: JN
authors.lastname: Constantino
mesh_terms: D000067877:Autism Spectrum Disorder / Q000523:psychology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D010290:Parents; D010641:Phenotype; D012677:Sensation; D012678:Sensation Disorders / Q000523:psychology*; D035781:Siblings / Q000523:psychology*; D012919:Social Behavior; D011795:Surveys and Questionnaires
keywords: Autism; Endophenotype; Family; Genetics; Sensory responsiveness