title: Association and interaction analysis of diabetes mellitus andSCN10Afor cardiovascular autonomic neuropathy in a Chinese population.
abstract: BACKGROUND
  This study assessed the extent to which diabetes mellitus (DM) andSCN10A(rs7375036) and their interaction impact on cardiovascular autonomic neuropathy (CAN) susceptibility in a Chinese Han sample.
  
  
  METHODS
  We performed a study in a cross-sectional dataset that included 419 patients with DM and 1557 controls who were genotyped for the presence of theSCN10Ars7375036 polymorphisms. Genotyping was performed by iPLEX technology. The associations of rs7375036 and DM with CAN was assessed by using univariate and multivariate logistic regression controlling for confounders. The interaction between rs7375036 and DM for CAN susceptibility on an additive scale was calculated by using the relative excess risk due to interaction (RERI), the proportion attributable to interaction (AP), and the synergy index (S).
  
  
  RESULTS
  The univariate logistic analyses failed to show an association between theSCN10Ars7375036 polymorphisms and CAN. Interestingly, a novel interaction effect ofSCN10Ars7375036 and DM on CAN was assessed (p=0.055; RERI=3.515, 95% CI 1.829 to 5.805; AP=0.632, 95% CI -0.368 to 1.632; S=4.361, 95% CI 2.071 to 9.184).
  
  
  CONCLUSIONS
  Our findings suggest that there are interaction effects of DM andSCN10A(rs7375036) that influence the development of CAN.
  
  
  BACKGROUND
  NCT02461342.
authors.affiliation: Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China.|Institutes of Integrative Medicine, Fudan University, Shanghai, China.
authors.forename: Yubao
authors.initials: Y
authors.lastname: Lv
authors.affiliation: Institution of Diabetology, Fudan University, Shanghai, China.
authors.forename: Linuo
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China.|Institutes of Integrative Medicine, Fudan University, Shanghai, China.
authors.forename: Zihui
authors.initials: Z
authors.lastname: Tang
authors.affiliation: Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China.|Institutes of Integrative Medicine, Fudan University, Shanghai, China.
authors.forename: Jingcheng
authors.initials: J
authors.lastname: Dong
mesh_terms: D001342:Autonomic Nervous System Diseases / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000235:genetics*; D002681:China; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D062559:NAV1.8 Voltage-Gated Sodium Channel / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D062559:NAV1.8 Voltage-Gated Sodium Channel; C568317:SCN10A protein, human
keywords: Chinese population; Diabetes Mellitus; SCN10A; cardiovascular autonomic neuropathy; interaction