title: New Initiation Modes for Directed Carbonylative C-C Bond Activation: Rhodium-Catalyzed (3 + 1 + 2) Cycloadditions of Aminomethylcyclopropanes.
abstract: Under carbonylative conditions, neutral Rh(I)-systems modified with weak donor ligands (AsPh3or 1,4-oxathiane) undergo N-Cbz, N-benzoyl, or N-Ts directed insertion into the proximal C-C bond of aminomethylcyclopropanes to generate rhodacyclopentanone intermediates. These are trapped by N-tethered alkenes to provide complex perhydroisoindoles.
authors.affiliation: School of Chemistry, University of Bristol , Bristol, BS8 1TS, United Kingdom.
authors.forename: Gang-Wei
authors.initials: GW
authors.lastname: Wang
authors.affiliation: School of Chemistry, University of Bristol , Bristol, BS8 1TS, United Kingdom.
authors.forename: Niall G
authors.initials: NG
authors.lastname: McCreanor
authors.affiliation: School of Chemistry, University of Bristol , Bristol, BS8 1TS, United Kingdom.
authors.forename: Megan H
authors.initials: MH
authors.lastname: Shaw
authors.affiliation: Syngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire, RG42 6EY, United Kingdom.
authors.forename: William G
authors.initials: WG
authors.lastname: Whittingham
authors.affiliation: School of Chemistry, University of Bristol , Bristol, BS8 1TS, United Kingdom.
authors.forename: John F
authors.initials: JF
authors.lastname: Bower