title: Spatially well-defined carbohydrate nanoplatforms: synthesis, characterization and lectin interaction study.
abstract: Two novel dodecasubstituted carbohydrate nanoplatforms based on molecular Borromean rings and dodecaamine cages have been prepared for use in evaluating the importance of the spatial distribution of carbohydrates in their interaction with lectins. The binding affinities of the glyconanoplatforms were characterized using quartz crystal microbalance technology and compared with a monovalent reference and dodecaglycosylated fullerenes.
authors.affiliation: KTH - Royal Institute of Technology, Department of Chemistry, Organic Chemistry, Teknikringen 36, S-100 44 Stockholm, Sweden. ramstrom@kth.se.
authors.forename: B J J
authors.initials: BJ
authors.lastname: Timmer
authors.affiliation: University of Namur, Départment de Chimie, Laboratoire de Chimie Bio-Organique, Rue de Bruxelles 61, B-5000 Namur, Belgium. stephane.vincent@unamur.be.
authors.forename: M Abellán
authors.initials: MA
authors.lastname: Flos
authors.affiliation: Attana AB, Björnnäsvägen 21, SE-114 19 Stockholm, Sweden. teodor.aastrup@attana.com.
authors.forename: L Mønster
authors.initials: LM
authors.lastname: Jørgensen
authors.affiliation: Attana AB, Björnnäsvägen 21, SE-114 19 Stockholm, Sweden. teodor.aastrup@attana.com.
authors.forename: D
authors.initials: D
authors.lastname: Proverbio
authors.affiliation: Attana AB, Björnnäsvägen 21, SE-114 19 Stockholm, Sweden. teodor.aastrup@attana.com.
authors.forename: S
authors.initials: S
authors.lastname: Altun
authors.affiliation: KTH - Royal Institute of Technology, Department of Chemistry, Organic Chemistry, Teknikringen 36, S-100 44 Stockholm, Sweden. ramstrom@kth.se.
authors.forename: O
authors.initials: O
authors.lastname: Ramström
authors.affiliation: Attana AB, Björnnäsvägen 21, SE-114 19 Stockholm, Sweden. teodor.aastrup@attana.com.
authors.forename: T
authors.initials: T
authors.lastname: Aastrup
authors.affiliation: University of Namur, Départment de Chimie, Laboratoire de Chimie Bio-Organique, Rue de Bruxelles 61, B-5000 Namur, Belgium. stephane.vincent@unamur.be.
authors.forename: S P
authors.initials: SP
authors.lastname: Vincent
mesh_terms: D002236:Carbohydrate Conformation; D002241:Carbohydrates / Q000737:chemistry*; D003208:Concanavalin A / Q000737:chemistry*; D037102:Lectins / Q000737:chemistry*; D008958:Models, Molecular; D036103:Nanotechnology / Q000379:methods*; D058525:Quartz Crystal Microbalance Techniques
chemical_list: D002241:Carbohydrates; D037102:Lectins; D003208:Concanavalin A