title: Natural and Synthetic Coumarins with Effects on Inflammation.
abstract: In this review, we will present the different aspects of coumarins and derivatives, from natural origins or synthetically prepared, and their action on inflammation. Coumarins and also furo- and pyranocoumarins are found in many different plants. These compounds are very often investigated for antioxidant properties. Other biological properties are also possible and anti-inflammation activity is one of these. As coumarins are also available quite easily via synthesis, natural ones can be prepared this way but derivatives with special substituents are also feasible. A review on the same topic appeared in 2004 and our contribution will take into account everything published since then.
authors.affiliation: SRSMC, UMR 7565, Groupe HeCRIN, ICPM, 1 boulevard Arago, 57070 Metz, France. gilbert.kirsch@univ-lorraine.fr.
authors.forename: Gilbert
authors.initials: G
authors.lastname: Kirsch
authors.affiliation: SRSMC, UMR 7565, Groupe HeCRIN, ICPM, 1 boulevard Arago, 57070 Metz, France. ahmed.mahmoud@univ-lorraine.fr.|Chemistry of Natural Compounds Department, National Research Centre, El-Behoos St. 33, 12622 Dokki-Cairo, Egypt. ahmed.mahmoud@univ-lorraine.fr.
authors.forename: Ahmed Bakr
authors.initials: AB
authors.lastname: Abdelwahab
authors.affiliation: SRSMC, UMR 7565, Groupe HeCRIN, ICPM, 1 boulevard Arago, 57070 Metz, France. patrick.chaimbault@univ-lorraine.fr.
authors.forename: Patrick
authors.initials: P
authors.lastname: Chaimbault
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011564:Furocoumarins / Q000494:pharmacology; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D039681:Pyranocoumarins / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D003374:Coumarins; D011564:Furocoumarins; D010936:Plant Extracts; D039681:Pyranocoumarins
keywords: coumarins; furocoumarins; inflammation; pyranocoumarins