title: The APOA5 rs662799 polymorphism is associated with dyslipidemia and the severity of coronary heart disease in Chinese women.
abstract: BACKGROUND
  The APOA5 rs662799 polymorphism has been widely reported regarding its associations with the plasma lipid levels and the occurrence of coronary heart disease (CHD), whereas its relationship with the severity of CHD has not yet been explored.
  
  
  METHODS
  Four hundred and seventy-eight angiografically defined subjects (325 CHD patients and 153 CHD-free controls) were enrolled in this study. The rs662799 polymorphism was genotyped, and the fasting lipid data were collected for all participants. The severity of CHD was evaluated for the CHD patients by using Gensini scores.
  
  
  RESULTS
  The variant C allele of the rs662799 polymorphism was associated with lower levels of HDL-C in CHD-free women, and higher levels of TG and TG/HDL-C in women with CHD (P < 0.05 for all). The C allele was associated with higher prevalence of dyslipidemia and higher levels of Gensini scores only in women (P < 0.05 for both), but not in men. Multivariate linear regression analysis showed that the rs662799 polymorphism was independently associated with the Gensini scores in women after adjustment for other potential CHD risk factors (Beta = 0.157, 95 % CI: 0.017-0.298, P = 0.028).
  
  
  CONCLUSIONS
  Our data indicate that the rs662799 polymorphism is associated with dyslipidemia and the severity of CHD in Chinese women.
authors.affiliation: Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.
authors.forename: Zhan
authors.initials: Z
authors.lastname: Lu
authors.affiliation: Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.
authors.forename: Jingxiao
authors.initials: J
authors.lastname: Zhang
authors.affiliation: School of Clinical Medicine, North Sichuan Medical College, Nanchong, 637000, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, 68583-0806, NE, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Shen
authors.affiliation: Department of Radiology, Sichuan Key Laboratory of Medical Imaging, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Medical Biochemistry, School of Preclinical Medicine, North Sichuan Medical College, Nanchong, 637000, China. songyongyan2014@foxmail.com.
authors.forename: Yongyan
authors.initials: Y
authors.lastname: Song
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D000072040:Apolipoprotein A-V / Q000235:genetics*; D044466:Asian People; D008076:Cholesterol, HDL / Q000097:blood / Q000235:genetics; D003327:Coronary Disease / Q000097:blood / Q000150:complications / Q000235:genetics* / Q000473:pathology; D050171:Dyslipidemias / Q000097:blood / Q000150:complications / Q000235:genetics* / Q000473:pathology; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
chemical_list: C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; D008076:Cholesterol, HDL; D008055:Lipids; D014280:Triglycerides
keywords: APOA5; Coronary heart disease; Lipid; Severity; rs662799