title: Diacylglycerol acyltransferase 1 (DGAT1) inhibition by furofuran lignans from stems of Acanthopanax senticosus.
abstract: Two new furofuran lignans were isolated from the stems of Acanthopanax senticosus, along with seven known compounds. Their structures were all determined by spectroscopic analyses and chemical methods. All the isolates were evaluated for in vitro inhibitory activity against DGAT1 and DGAT2. Compounds 1 and 2 were found to exhibit selective inhibitory activity on DGAT1 with IC50values 89.5 ± 1.5 and 57.5 ± 1.3 µM, respectively.
authors.affiliation: College of Pharmacy, Beihua University, 3999 Binjiangdong Road, Jilin City, 132013, Jilin Province, China.
authors.forename: Ban-Ban
authors.initials: BB
authors.lastname: Li
authors.affiliation: College of Pharmacy, Beihua University, 3999 Binjiangdong Road, Jilin City, 132013, Jilin Province, China.
authors.forename: Jia-Lin
authors.initials: JL
authors.lastname: Li
authors.affiliation: College of Pharmacy, Beihua University, 3999 Binjiangdong Road, Jilin City, 132013, Jilin Province, China.
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.affiliation: College of Pharmacy, Beihua University, 3999 Binjiangdong Road, Jilin City, 132013, Jilin Province, China.
authors.forename: Shi-Zhou
authors.initials: SZ
authors.lastname: Qi
authors.affiliation: Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Ch'ongju, Chungbuk, 363-883, South Korea.
authors.forename: Hyun-Sun
authors.initials: HS
authors.lastname: Lee
authors.affiliation: College of Pharmacy, Beihua University, 3999 Binjiangdong Road, Jilin City, 132013, Jilin Province, China.
authors.forename: Le
authors.initials: L
authors.lastname: Zhang
authors.affiliation: College of Pharmacy, Beihua University, 3999 Binjiangdong Road, Jilin City, 132013, Jilin Province, China.
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Xing
authors.affiliation: College of Pharmacy, Beihua University, 3999 Binjiangdong Road, Jilin City, 132013, Jilin Province, China.
authors.forename: Zhen-Dong
authors.initials: ZD
authors.lastname: Tuo
authors.affiliation: College of Pharmacy, Beihua University, 3999 Binjiangdong Road, Jilin City, 132013, Jilin Province, China. cuilong71@beihua.edu.cn.
authors.forename: Long
authors.initials: L
authors.lastname: Cui
mesh_terms: D051048:Diacylglycerol O-Acyltransferase / Q000037:antagonists & inhibitors*; D028001:Eleutherococcus / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D057809:HEK293 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018547:Plant Stems; D013057:Spectrum Analysis
chemical_list: D004791:Enzyme Inhibitors; D017705:Lignans; C494881:DGAT1 protein, human; C494885:DGAT2 protein, human; D051048:Diacylglycerol O-Acyltransferase
keywords: Acanthopanax senticosus; Araliaceae; DGAT; Furofuran lignans