title: Immunomodulatory Effect ofH. Pylori CagAGenotype and Gastric Hormones On Gastric Versus Inflammatory Cells Fas Gene Expression in Iraqi Patients with Gastroduodenal Disorders.
abstract: OBJECTIVE
  To evaluate the Immunomodulatory effects ofCagAexpression; pepsinogen I, II & gastrin-17 on PMNs and lymphocytes Fas expression in inflammatory and gastric cells; demographic distribution of Fas molecule in gastric tissue and inflammatory cells.
  
  
  METHODS
  Gastroduodenal biopsies were taken from 80 patients for histopathology andH. pyloridiagnosis. Serum samples were used for evaluation of pepsinogen I (PGI); (PGII); gastrin-17 (G-17).
  
  
  RESULTS
  Significant difference (p < 0.001) in lymphocytes & PMNs Fas expression; epithelial & lamina propria Fas localization amongH. pyloriassociated gastric disorders. No correlation between grade of lymphocytes & PMNs Fas expression in gastric epithelia; lamina propria and types of gastric disorder. Significant difference (p < 0.001) in total gastric Fas expression, epithelial Fas; lamina propria and gastric gland Fas expression according toCagA, PGI; PGII; PGI/PGII; Gastrin-17. Total gastric Fas expression has significant correlation withCagA, PGII levels. Gastric epithelial and gastric lamina propria Fas expression have significant correlation withCagA, PGI; PGII levels. Significant difference (p < 0.001) was found in lymphocytes & PMNs Fas expression; epithelial & lamina propria localization of lymphocytes & PMNs Fas expression according toCagA, PGI; PGII; PGI/PGII; Gastrin-17. Lymphocytes Fas expression have correlation with PGI, PGII, PGI/PGII. PMNs Fas expression have correlation with PGI, PGII.
  
  
  CONCLUSIONS
  Fas gene expression and localization on gastric and inflammatory cells affected directly byH. pylori CagAand indirectly by gastric hormones. This contributes to progression of various gastric disorders according to severity ofCagAinduced gastric pathology and gastric hormones disturbance throughout the course of infection and disease.
authors.affiliation: Department of Pathology, College of Veterinary Medicine, Diyala University, Baquba, Diyala Province, Iraq.
authors.forename: Ali Ibrahim Ali
authors.initials: AI
authors.lastname: Al-Ezzy
keywords: CagA; Fas gene; H. pylori; gastric disorders; gastrin -17; pepsinogens