title: H3K36 methylation state and associated silencing mechanisms.
abstract: Epigenetic marks determine cell fate via numerous reader proteins. H3K36 methylation is a common epigenetic mark that is thought to be associated with the activities of the RNA polymerase 2 C-terminal domain. We discuss a novel silencing mechanism regulated by Set2-dependent H3K36 methylation that involves exosome-dependent RNA processing.
authors.affiliation: a Department of Chemistry , Faculty of Science, Hokkaido University , Sapporo , Japan.
authors.forename: Shota
authors.initials: S
authors.lastname: Suzuki
authors.affiliation: a Department of Chemistry , Faculty of Science, Hokkaido University , Sapporo , Japan.
authors.forename: Yota
authors.initials: Y
authors.lastname: Murakami
authors.affiliation: a Department of Chemistry , Faculty of Science, Hokkaido University , Sapporo , Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Takahata
mesh_terms: D044127:Epigenesis, Genetic; D005091:Exons; D020868:Gene Silencing; D011495:Histone-Lysine N-Methyltransferase / Q000378:metabolism*; D006657:Histones / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008239:Lysine / Q000737:chemistry; D008297:Male; D008745:Methylation; D000072417:Protein Domains; D012319:RNA Polymerase II / Q000737:chemistry / Q000378:metabolism*
chemical_list: D006657:Histones; D011495:Histone-Lysine N-Methyltransferase; D012319:RNA Polymerase II; D008239:Lysine
keywords: H3K36me; HDAC; Set2; epigenetics; exosome; heterochromatin