title: An Orbital Malignant Melanoma Arising in Cellular Blue Nevus in a Patient with Nevus of Ota.
abstract: Melanomas arising from orbital melanocytic proliferations are exceedingly rare. Many questions remain regarding their development and malignant transformation. We report on a 45-year-old Caucasian woman with a nevus of Ota that presented with visual disturbances involving her right eye and was found to have a biopsy-proven cellular blue nevus in the orbital space. Five years later, she presented with proptosis and worsening symptoms. Biopsy at that time showed a cellular blue nevus with areas of melanoma. We conclude that patients with a nevus of Ota or an orbital cellular blue nevus, particularly Caucasians, should be monitored for ocular/orbital involvement and followed closely for signs of rapid growth. There may be a progressive evolution to melanoma from a blue nevus.
authors.affiliation: University of Central Florida College of Medicine.
authors.forename: Talayesa
authors.initials: T
authors.lastname: Buntinx-Krieg
authors.affiliation: Department of Pathology, Florida Hospital.
authors.forename: Jie
authors.initials: J
authors.lastname: Ouyang
authors.affiliation: Medical Eye Associates, University of Central Florida College of Medicine.
authors.forename: Mont
authors.initials: M
authors.lastname: Cartwright
keywords: cellular blue nevus; congenital melanosis bulbi; malignant melanoma; melanoma; nevus fuscoceruleus ophthalmomaxillaris; nevus of ota; oculodermal melanocytosis; oculodermal melanosis; orbit; orbital melanoma