title: Directed Evolution of Iridium-Substituted Myoglobin Affords Versatile Artificial Metalloenzymes for Enantioselective C-C Bond-Forming Reactions.
abstract: Upgrading myoglobin with iridium: A metal-substitution strategy has been used to afford a repurposed myoglobin for challenging cyclopropanation and intramolecular C-H activation reactions. The performance of the iridium-loaded myoglobin (orange sphere) was improved through directed evolution of eight active-site residues (yellow surface).
authors.affiliation: Department of Chemistry, University of Basel, Spitalstrasse 51, 4051, Basel, Switzerland.
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Ward
keywords: C−H activation; artificial enzymes; biocatalysis; bioinorganic chemistry; metalloenzymes