title: Pathophysiology, research challenges, and clinical management of smoke inhalation injury.
abstract: Smoke inhalation injury is a serious medical problem that increases morbidity and mortality after severe burns. However, relatively little attention has been paid to this devastating condition, and the bulk of research is limited to preclinical basic science studies. Moreover, no worldwide consensus criteria exist for its diagnosis, severity grading, and prognosis. Therapeutic approaches are highly variable depending on the country and burn centre or hospital. In this Series paper, we discuss understanding of the pathophysiology of smoke inhalation injury, the best evidence-based treatments, and challenges and future directions in diagnostics and management.
authors.affiliation: Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA. Electronic address: peenkhba@utmb.edu.
authors.forename: Perenlei
authors.initials: P
authors.lastname: Enkhbaatar
authors.affiliation: Department of Surgery, Division of Trauma, University of Texas Health Science Center, San Antonio, TX, USA.
authors.forename: Basil A
authors.initials: BA
authors.lastname: Pruitt
authors.affiliation: Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA; Shriners Hospitals for Children, Galveston, TX, USA.
authors.forename: Oscar
authors.initials: O
authors.lastname: Suman
authors.affiliation: Shriners Hospitals for Children, Galveston, TX, USA; Department of Respiratory Care, School of Health Professions, University of Texas Medical Branch, Galveston, TX, USA.
authors.forename: Ronald
authors.initials: R
authors.lastname: Mlcak
authors.affiliation: Department of Surgery, University of Texas, Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Steven E
authors.initials: SE
authors.lastname: Wolf
authors.affiliation: Department of Plastic and Reconstructive Surgery, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sakurai
authors.affiliation: Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA; Shriners Hospitals for Children, Galveston, TX, USA.
authors.forename: David N
authors.initials: DN
authors.lastname: Herndon
mesh_terms: D002056:Burns; D006801:Humans; D011379:Prognosis; D012106:Research; D015208:Smoke Inhalation Injury / Q000175:diagnosis*