title: Five new lactone derivatives from the stems of Dendrobium nobile.
abstract: Five new lactone derivatives decumbic acids A and B (1 and 2), (-)-decumbic acid (3a), (-)- and (+)-dendrolactone (4a and 4b) together with four known compounds (3b and 5-7) were isolated from the stems of Dendrobium nobile. Their structures were elucidated using comprehensive spectroscopic methods. Compounds 3a and 3b, 4a and 4b were isolated as two pair of enantiomers by chiral HPLC. The absolute configurations of 1, 2, 3a, 4a and 4b were determined by optical rotation and X-ray crystallographic analysis. The inhibitory activities of all compounds against nine phytopathogenic fungi and three cancer cell lines were evaluated.
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.
authors.forename: Xue-Ming
authors.initials: XM
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.
authors.forename: Cai-Juan
authors.initials: CJ
authors.lastname: Zheng
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.
authors.forename: Jia-Ting
authors.initials: JT
authors.lastname: Wu
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China. Electronic address: chgying123@163.com.
authors.forename: Guang-Ying
authors.initials: GY
authors.lastname: Chen
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.affiliation: Hainan Boying Orchid Industrial Development Co., LTD, Haikou 570105, China.
authors.forename: Chong-Ge
authors.initials: CG
authors.lastname: Sun
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification; D045744:Cell Line, Tumor; D031667:Dendrobium / Q000737:chemistry*; D005658:Fungi / Q000187:drug effects; D006801:Humans; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones
keywords: Antifungal; Butyrolactone; Cytotoxic; Dendrobium nobile