title: Linezolid Toxicity and Mitochondrial Susceptibility: A Novel Neurological Complication in a Lebanese Patient.
abstract: The recent rise in the use of linezolid to treat a variety of resistant pathogens has uncovered many side effects. Some patients develop lactic acidosis, myelosuppression, optic or peripheral neuropathies, and myopathies. We evaluated an elderly patient who presented to the Emergency Room with linezolid toxicity and a novel neurologic complication characterized by bilateral globi pallidi necrosis. Mitochondrial ribosome inhibition was described to be the predisposing factor. The patient belongs to the mitochondrial J1 haplotype known to be associated with side effects of the drug. We recommend based on the molecular profile of the illness pretreatment considerations and complication management.
authors.affiliation: Department of Internal Medicine, American University of Beirut Medical Center, American University of Beirut, Beirut Lebanon.
authors.forename: Ossama K
authors.initials: OK
authors.lastname: Abou Hassan
authors.affiliation: Department of Internal Medicine, American University of Beirut Medical Center, American University of Beirut, Beirut Lebanon.
authors.forename: Mohamad
authors.initials: M
authors.lastname: Karnib
authors.affiliation: MMA-Neuromuscular Diagnostic Lab, Department of Pathology and Lab Medicine, American University of Beirut Medical Center, American University of Beirut, Beirut Lebanon.
authors.forename: Riyad
authors.initials: R
authors.lastname: El-Khoury
authors.affiliation: Department of Biochemistry and Molecular Genetics, American University of Beirut, Beirut Lebanon.
authors.forename: Georges
authors.initials: G
authors.lastname: Nemer
authors.affiliation: MMA-Neuromuscular Diagnostic Lab, Department of Pathology and Lab Medicine, American University of Beirut Medical Center, American University of Beirut, Beirut Lebanon.
authors.forename: Mamdouha
authors.initials: M
authors.lastname: Ahdab-Barmada
authors.affiliation: Department of Internal Medicine, American University of Beirut Medical Center, American University of Beirut, Beirut Lebanon.
authors.forename: Pierre
authors.initials: P
authors.lastname: BouKhalil
keywords: J1 haplogroup; globus pallidus; linezolid; mitochondria; toxicity