title: Swertisin ameliorates pre-pulse inhibition deficits and cognitive impairment induced by MK-801 in mice.
abstract: Swertisin, a plant-derived C-glucosylflavone, is known to have antidiabetic, anti-inflammatory and antioxidant effects. In the present study, we investigated in mice the effects of swertisin on glutamatergic dysfunction induced by dizocilpine (MK-801), a non-competitive N-methyl-D-aspartate receptor antagonist. In the Acoustic Startle Response test, their MK-801-induced (given 0.2 mg/kg i.p.) pre-pulse inhibition deficit was significantly attenuated by the administration of swertisin (30 mg/kg p.o.). In the Novel Object Recognition Test, the recognition memory impairments that were induced by MK-801 (0.2 mg/kg, given i.p.) were also reversed by administration of swertisin (30 mg/kg p.o.). In addition, swertisin normalized the MK-801-induced elevation of phosphorylation levels of Akt and GSK-3β signaling molecules in the prefrontal cortex. These results indicated that swertisin may be useful in managing the symptoms of schizophrenia, including sensorimotor gating disruption and cognitive impairment, and that these behavioral outcomes may be related to Akt-GSK-3β signaling in the prefrontal cortex.
authors.affiliation: 1 Department of Oriental Pharmaceutical Science, Kyung Hee University, Seoul, Republic of Korea.|4 Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea.
authors.forename: Hee Kyong
authors.initials: HK
authors.lastname: Oh
authors.affiliation: 2 Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul, Republic of Korea.|3 Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Se Jin
authors.initials: SJ
authors.lastname: Jeon
authors.affiliation: 2 Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul, Republic of Korea.|3 Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Sunhee
authors.initials: S
authors.lastname: Lee
authors.affiliation: 2 Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul, Republic of Korea.|3 Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Hyung Eun
authors.initials: HE
authors.lastname: Lee
authors.affiliation: 2 Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul, Republic of Korea.|3 Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Eunji
authors.initials: E
authors.lastname: Kim
authors.affiliation: 2 Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul, Republic of Korea.|3 Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Se Jin
authors.initials: SJ
authors.lastname: Park
authors.affiliation: 2 Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul, Republic of Korea.|3 Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Ha Neul
authors.initials: HN
authors.lastname: Kim
authors.affiliation: 1 Department of Oriental Pharmaceutical Science, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Won Yong
authors.initials: WY
authors.lastname: Jung
authors.affiliation: 5 Uimyung Research Institute for Neuroscience, Sahmyook University, Seoul, Republic of Korea.
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Cheong
authors.affiliation: 2 Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul, Republic of Korea.|3 Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Dae Sik
authors.initials: DS
authors.lastname: Jang
authors.affiliation: 1 Department of Oriental Pharmaceutical Science, Kyung Hee University, Seoul, Republic of Korea.|2 Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul, Republic of Korea.|3 Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Jong Hoon
authors.initials: JH
authors.lastname: Ryu
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000818:Animals; D047310:Apigenin / Q000494:pharmacology*; D060825:Cognitive Dysfunction / Q000139:chemically induced* / Q000188:drug therapy* / Q000378:metabolism; D016291:Dizocilpine Maleate / Q000009:adverse effects*; D005419:Flavonoids / Q000494:pharmacology; D038362:Glycogen Synthase Kinase 3 / Q000378:metabolism; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced* / Q000188:drug therapy* / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D010766:Phosphorylation / Q000187:drug effects; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D013216:Reflex, Startle / Q000187:drug effects; D012559:Schizophrenia / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism; D055139:Sensory Gating / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects
chemical_list: C421808:C-glucosylflavone; D005419:Flavonoids; C556941:swertisin; D016291:Dizocilpine Maleate; D047310:Apigenin; D051057:Proto-Oncogene Proteins c-akt; D038362:Glycogen Synthase Kinase 3
keywords: Cognitive impairment; mechanism of action; mouse study; pharmacological treatment; prepulse inhibition; schizophrenia; sensorimotor gating; startle response; swertisin