title: Types of laryngomalacia in children: interrelationship between clinical course and comorbid conditions.
abstract: The aim of this study was to: (1) find out whether laryngomalacia (LM) types are related to clinical course; (2) which patients with LM are at higher risk of other airway malacia [tracheomalacia (TM) and/or bronchomalacia (BM)]; and (3) evaluate the prevalence of LM in our region. Patients with established LM diagnosis and complete clinical and endoscopy records were enrolled. They were classified into different LM types according to classification based on the side of supraglottic obstruction. One hundred ten children were included. The most common LM appearance was type I-58 children, followed by combine types (I + II and I + III)-38. The other airway malacia were found in 47 patients: TM in 31, BM in 10, and TM with BM in 6. Other comorbidities (cardiac, neurological, and genetic disorders) were identified in 30 children. Patients with combine types of LM differ from those with single type of LM in terms of prematurity (13 vs 31 %, p = 0.04) and higher weight on the examination day (p = 0.006). Patients with other airway malacia differ from children with isolated LM in terms of prematurity (40 vs 13 %, p = 0.008), comorbidities (38 vs 19 %, p = 0.024), and lower weight on the examination day (p = 0.014). The prevalence of clinically relevant LM was one in 2600-3100 newborns. Clinical course of LM cannot be anticipated on the basis of solely endoscopic evaluation of the larynx. Comorbidities and prematurity increase the risk of other airway malacia. The prevalence of LM is relatively high in the middle-south part of Poland.
authors.affiliation: Department of Pediatrics, Chair of Pediatrics Jagiellonian University Medical College, Krakow, Poland. beatakusak@gmail.com.|University Children's Hospital, Wielicka 265 str., 30-663, Krakow, Poland. beatakusak@gmail.com.
authors.forename: Beata
authors.identifier: http://orcid.org/0000-0002-4865-5933
authors.initials: B
authors.lastname: Kusak
authors.affiliation: Department of Pediatrics, Chair of Pediatrics Jagiellonian University Medical College, Krakow, Poland.|University Children's Hospital, Wielicka 265 str., 30-663, Krakow, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Cichocka-Jarosz
authors.affiliation: Department of Pediatrics, Chair of Pediatrics Jagiellonian University Medical College, Krakow, Poland.|University Children's Hospital, Wielicka 265 str., 30-663, Krakow, Poland.
authors.forename: Urszula
authors.initials: U
authors.lastname: Jedynak-Wasowicz
authors.affiliation: Department of Pediatrics, Chair of Pediatrics Jagiellonian University Medical College, Krakow, Poland.|University Children's Hospital, Wielicka 265 str., 30-663, Krakow, Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Lis
mesh_terms: D000402:Airway Obstruction / Q000473:pathology / Q000503:physiopathology; D055091:Bronchomalacia / Q000453:epidemiology*; D001999:Bronchoscopy / Q000379:methods; D015897:Comorbidity; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D055092:Laryngomalacia / Q000145:classification / Q000453:epidemiology / Q000503:physiopathology; D008297:Male; D011044:Poland / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D059525:Supraglottitis / Q000473:pathology; D055090:Tracheomalacia / Q000453:epidemiology*
keywords: Bronchomalacia; Comorbidities; Laryngomalacia; Tracheomalacia