title: Can low BMI Chinese patients with type 2 diabetes benefit from laparoscopic Roux-en-Y gastric bypass surgery?
abstract: BACKGROUND
  The efficacy of laparoscopic Roux-en-Y gastric bypass (LRYGB) in type 2 diabetes mellitus (T2D) is closely associated with the preoperative body mass index (BMI) of the patient. There is a lack of long-term and large sampling evidence on the efficacy of LRYGB in T2D patients with low BMI in China.
  
  
  OBJECTIVE
  This retrospective study aimed to evaluate the efficacy of surgical treatment in a Chinese population with T2D (especially patients with BMI<27.5 kg/m2).
  
  
  METHODS
  University-affiliated hospital, China METHODS: Seventy-eight patients with T2D were included in the study and evaluated before and after LRYGB surgery. No patients were lost to follow-up at any time points.
  
  
  RESULTS
  Thirty-eight T2D patients with BMI≥27.5 kg/m2in group 1 (high BMI group) had significant improvements in waist circumference, blood glucose levels, homeostasis model assessment-insulin resistance index, and C-peptide levels after LRYGB (P<.05). Forty T2D patients with BMI<27.5 kg/m2in group 2 (low BMI group, including 19 T2D patients with BMI<25 kg/m2) had significant improvements in waist circumference and waist-to-hip ratio after LRYGB (P< .05).
  
  
  CONCLUSIONS
  LRYGB surgery may be beneficial in T2D patients with BMI<27.5 kg/m2in China.
authors.affiliation: Centre of Experimental Medicine, Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Guohui
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Liyong
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Department of General Surgery, Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Weizheng
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of General Surgery, Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Xiangwu
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of General Surgery, Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Pengzhou
authors.initials: P
authors.lastname: Li
authors.affiliation: Centre of Experimental Medicine, Third Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of General Surgery, Third Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: 3545901@qq.com.
authors.forename: Shaihong
authors.initials: S
authors.lastname: Zhu
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D016063:Blood Loss, Surgical; D015992:Body Mass Index; D002681:China / Q000208:ethnology; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology / Q000601:surgery*; D005260:Female; D015390:Gastric Bypass / Q000379:methods*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D010535:Laparoscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D061646:Operative Time; D012189:Retrospective Studies; D055105:Waist Circumference; D055815:Young Adult
keywords: Body mass index (BMI); Chinese population; Insulin resistance; Laparoscopic Roux-en-Y gastric bypass (LRYGB); Type II diabetes