title: Investigation of Formulation and Process of Lyophilised Orally Disintegrating Tablet (ODT) Using Novel Amino Acid Combination.
abstract: Lyophilised orally disintegrating tablets (ODTs) have achieved a great success in overcoming dysphagia associated with conventional solid dosage forms. However, the extensive use of saccharides within the formulation limits their use in treatment of chronic illnesses. The current study demonstrates the feasibility of using combination of proline and serine to formulate zero sacharide ODTs and investigates the effect of freezing protocol on sublimation rate and tablets characteristics. The results showed that inclusion of proline and serine improved ODT properties when compared to individual counterparts. Additionally, annealing the ODTs facilitated the sublimation process and shortened the disintegration time.
authors.affiliation: Aston Pharmacy School, Aston University, Birmingham B4 7ET, UK.
authors.forename: Farhan
authors.initials: F
authors.lastname: AlHusban
authors.affiliation: Aston Pharmacy School, Aston University, Birmingham B4 7ET, UK.
authors.forename: Amr M
authors.initials: AM
authors.lastname: ElShaer
authors.affiliation: Aston Pharmacy School, Aston University, Birmingham B4 7ET, UK.
authors.forename: Jiteen H
authors.initials: JH
authors.lastname: Kansara
authors.affiliation: School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
authors.forename: Alan M
authors.initials: AM
authors.lastname: Smith
authors.affiliation: School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
authors.forename: Liam M
authors.initials: LM
authors.lastname: Grover
authors.affiliation: Aston Pharmacy School, Aston University, Birmingham B4 7ET, UK.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Perrie
authors.affiliation: Aston Pharmacy School, Aston University, Birmingham B4 7ET, UK. a.u.r.mohammed@aston.ac.uk.
authors.forename: Afzal R
authors.initials: AR
authors.lastname: Mohammed
keywords: annealing; lyophilisation; orally disintegrating tablets; proline; serine; sublimation rate