title: Copper(i)-catalysed oxidative C-N coupling of 2-aminopyridine with terminal alkynes featuring a C[triple bond, length as m-dash]C bond cleavage promoted by visible light.
abstract: Facile visible-light promoted copper-catalyzed aerobic oxidative C-N coupling between 2-aminopyridine and terminal alkynes at room temperature via C[triple bond, length as m-dash]C triple bond cleavage is described. This reaction allows direct synthesis of biologically important pyridyl amides by utilization of commercially available starting materials without the need for bases/external oxidants.
authors.affiliation: Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan, Republic of China. kchwang@mx.nthu.edu.tw.
authors.forename: Ayyakkannu
authors.initials: A
authors.lastname: Ragupathi
authors.affiliation: Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan, Republic of China. kchwang@mx.nthu.edu.tw.
authors.forename: Arunachalam
authors.initials: A
authors.lastname: Sagadevan
authors.affiliation: Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan, Republic of China. kchwang@mx.nthu.edu.tw.
authors.forename: Chun-Cheng
authors.initials: CC
authors.lastname: Lin
authors.affiliation: Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan, Republic of China. kchwang@mx.nthu.edu.tw.
authors.forename: Jih-Ru
authors.initials: JR
authors.lastname: Hwu
authors.affiliation: Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan, Republic of China. kchwang@mx.nthu.edu.tw.
authors.forename: Kuo Chu
authors.initials: KC
authors.lastname: Hwang