title: Tumour-Targeted Drug Delivery with Mannose-Functionalized Nanoparticles Self-Assembled from Amphiphilic β-Cyclodextrins.
abstract: Multivalent mannose-functionalized nanoparticles self-assembled from amphiphilic β-cyclodextrins (β-CDs) facilitate the targeted delivery of anticancer drugs to specific cancer cells. Doxorubicin (DOX)-loaded nanoparticles equipped with multivalent mannose target units were efficiently taken up via receptor-mediated endocytosis by MDA-MB-231 breast cancer cells that overexpress the mannose receptor. Upon entering the cell, the intracellular pH causes the release of DOX, which triggers apoptosis. Targeting by multivalent mannose significantly improved the capability of DOX-loaded nanoparticles to inhibit the growth of MDA-MB-231 cancer cells with minimal side effects in vivo. This targeted and controlled drug delivery system holds promise as a nanotherapeutic for cancer treatment.
authors.affiliation: Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, 214122, P. R. China.|Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476, Potsdam, Germany.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Ye
authors.affiliation: Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, 214122, P. R. China.|Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476, Potsdam, Germany.
authors.forename: Quan
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, 214122, P. R. China.
authors.forename: Shengtao
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476, Potsdam, Germany.
authors.forename: Priya
authors.initials: P
authors.lastname: Bharate
authors.affiliation: Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476, Potsdam, Germany.
authors.forename: Silvia
authors.initials: S
authors.lastname: Varela-Aramburu
authors.affiliation: Institute of Virology, University Hospital Essen, Virchowstrasse 179, 45147, Essen, Germany.
authors.forename: Mengji
authors.initials: M
authors.lastname: Lu
authors.affiliation: Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476, Potsdam, Germany. peter.seeberger@mpikg.mpg.de.
authors.forename: Peter H
authors.initials: PH
authors.lastname: Seeberger
authors.affiliation: Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, 214122, P. R. China. jianyin@jiangnan.edu.cn.
authors.forename: Jian
authors.initials: J
authors.lastname: Yin
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D016503:Drug Delivery Systems; D005260:Female; D006801:Humans; D037181:Lectins, C-Type; D008358:Mannose / Q000737:chemistry / Q000494:pharmacology*; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D053758:Nanoparticles; D011956:Receptors, Cell Surface; D047392:beta-Cyclodextrins / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D037181:Lectins, C-Type; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D011956:Receptors, Cell Surface; D047392:beta-Cyclodextrins; D004317:Doxorubicin; D008358:Mannose
keywords: cancer chemotherapy; mannose-mediated targeting; multivalency; nanoparticles; targeted drug delivery