title: [Progressive multifocal leukoencephalopathy].
abstract: Progressive multifocal leukoencephalopathy (PML) is a disease of immunosuppressed patients caused by the JC polyomavirus (JCPyV). Due to the elevated risk in patients treated with natalizumab for multiple sclerosis (MS) and also treatment with other biologicals for different indications, the relevance of PML has increased in recent years. This article summarizes the published knowledge on the biology and pathogenesis of PML with a focus on the role of cerebrospinal fluid diagnostics in the work-up for PML and the current PML case definition. Current recommendations regarding risk management are discussed, as are possible therapies and prevention.
authors.affiliation: Klinik für Neurologie, Medizinische Fakultät, Universitätsklinikum Düsseldorf, Heinrich-Heine-Universität Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Deutschland. warnke@uni-duesseldorf.de.
authors.forename: C
authors.initials: C
authors.lastname: Warnke
authors.affiliation: Abteilung für Radiologie und Nuklearmedizin, VU University Medical Center, Amsterdam, Niederlande.
authors.forename: M P
authors.initials: MP
authors.lastname: Wattjes
authors.affiliation: Institut für Virologie, Medizinische Fakultät, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Deutschland.
authors.forename: O
authors.initials: O
authors.lastname: Adams
authors.affiliation: Klinik für Neurologie, Medizinische Fakultät, Universitätsklinikum Düsseldorf, Heinrich-Heine-Universität Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Deutschland.
authors.forename: H-P
authors.initials: HP
authors.lastname: Hartung
authors.affiliation: Klinik für Neurologie, Universitätsspital Zürich, Zürich, Schweiz.
authors.forename: R
authors.initials: R
authors.lastname: Martin
authors.affiliation: Klinik für Neurologie, Kath. Marienkrankenhaus, Hamburg, Deutschland.
authors.forename: T
authors.initials: T
authors.lastname: Weber
authors.affiliation: Klinik für Neurologie, Medizinische Hochschule Hannover, Hannover, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: Stangel
mesh_terms: D015415:Biomarkers / Q000134:cerebrospinal fluid*; D019090:Case Management / Q000458:organization & administration*; D003943:Diagnostic Techniques, Neurological; D019317:Evidence-Based Medicine; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers
keywords: Cerebrospinal fluid; JC polyomavirus; Multiple sclerosis; Natalizumab; PML