title: Transcriptomic characterization of differential gene expression in oral squamous cell carcinoma: a meta-analysis of publicly available microarray data sets.
abstract: Oral squamous cell carcinoma (OSCC) is a highly prevalent cancer worldwide, and OSCC often goes undiagnosed until advanced disease is present, which contributes to a low survival rate for OSCC patients. The identification of biomarkers for the early detection OSCC and novel therapeutic targets for OSCC treatment is an important research objective. We performed bioinformatics analyses of the gene expression profile of OSCC using microarray data to identify genes that contribute to the development of OSCC. We also predicted the transcription factors involved in the regulation of differential gene expression in OSCC. Our results showed that PI3K, EGFR, STAT1, and CPBP are important contributors to the changes in cellular physiology that occur during the development of OSCC. Therefore, these genes represent potential diagnostic biomarkers and therapeutic targets for OSCC.
authors.affiliation: Department of Stomatology, Zhongshan Hospital, Fudan University, 111 Yixueyuan Road, Shanghai, 200032, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Stomatology, Zhongshan Hospital, Fudan University, 111 Yixueyuan Road, Shanghai, 200032, China.
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Sang
authors.affiliation: Department of Stomatology, Zhongshan Hospital, Fudan University, 111 Yixueyuan Road, Shanghai, 200032, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Jiang
authors.affiliation: Department of Stomatology, Zhongshan Hospital, Fudan University, 111 Yixueyuan Road, Shanghai, 200032, China. Dingxiaojun051214@163.com.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Ding
authors.affiliation: Department of Stomatology, Zhongshan Hospital, Fudan University, 111 Yixueyuan Road, Shanghai, 200032, China.
authors.forename: Youcheng
authors.initials: Y
authors.lastname: Yu
keywords: Differentially expressed gene (DEG); Head and neck squamous cell carcinoma (HNSCC); Healthy oral squamous cell (HOSC); Oral squamous cell carcinoma (OSCC)