title: Formulation and in vitro evaluation of colchicines and naproxen sodium sustain release tablets in combination for treatment of gout.
abstract: Present investigation concern with combination of two drugs for the treatment of gout. One of these drug (naproxen sodium) is pain killer which is sustain their action within the body for 12 hours and the other drug (colchicine) is anti-gout, which release as conventional dosage. After oral administration naproxen will act as sustain release dosage and increase patient compliance about six batches of tablet were developed and evaluate .For the sustain release action polymers Methocel K4M and HPMCK15were used. These polymers were used in combination used with other inactive ingredients. Two methods were used for proration of final tablets. In 1st method only naproxen sodium granules were prepared which are sustained released. In second method these granules were mixed with colchicines powder and other all inactive ingredients. This method is easy and cost effective characterization of pallets and final tablets were performed. Final tablets were evaluated for all tests like appearance, friability, dissolution, hardness, assay, weight variation and in-vitro release study performed. The results obtained were satisfactory and complies with USP specification. Formulation containing combination of Methocel K4M and HPMC K15 showed good sustain release profile for 12 hours.
authors.affiliation: Faculty of Pharmacy, University of Central Punjab, Lahore Pakistan.
authors.forename: Yasir
authors.initials: Y
authors.lastname: Mehmood
authors.affiliation: Rashid Latif College of Pharmacy Lahore, Pakistan.
authors.forename: Humayun
authors.initials: H
authors.lastname: Riaz
authors.affiliation: Faculty of Pharmacy, University of Central Punjab, Lahore Pakistan.
authors.forename: Hammad
authors.initials: H
authors.lastname: Yousaf
authors.affiliation: University College of Pharmacy, Punjab University, Lahore, Pakistan.
authors.forename: Syed Atif
authors.initials: SA
authors.lastname: Raza
authors.affiliation: College of pharmacy, Hajvery University, Lahore, Pakistan.
authors.forename: Rana Khalid
authors.initials: RK
authors.lastname: Mahmood
authors.affiliation: Rashid Latif College of Pharmacy Lahore, Pakistan.
authors.forename: Zia Mohy-Ud-Din
authors.initials: ZM
authors.lastname: Khan
authors.affiliation: Rashid Latif College of Pharmacy Lahore, Pakistan.
authors.forename: Noviara
authors.initials: N
authors.lastname: Saleem
mesh_terms: D000284:Administration, Oral; D003078:Colchicine / Q000008:administration & dosage / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D004339:Drug Compounding; D004355:Drug Stability; D006074:Gout Suppressants / Q000008:administration & dosage / Q000737:chemistry*; D065347:Hypromellose Derivatives / Q000737:chemistry; D007700:Kinetics; D008956:Models, Chemical; D009288:Naproxen / Q000008:administration & dosage / Q000737:chemistry*; D012995:Solubility; D013607:Tablets; D014867:Water / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D004338:Drug Combinations; D006074:Gout Suppressants; D013607:Tablets; D014867:Water; D065347:Hypromellose Derivatives; D009288:Naproxen; D003078:Colchicine