title: Synthesis and deposition of a Tröger's base polymer on the electrode surface for potentiometric detection of a neuroblastoma tumor marker metabolite.
abstract: The development of novel diagnostic tools is a primary goal in bioanalytical chemistry. Here we report the synthesis of Tröger's base functionalized with amino- and coumarin-units designed as a monomeric unit for the development of an electrochemical cancer sensor. The synthesized receptor was deposited onto a conducting support using electrochemical polymerization, characterized spectroscopically and tested potentiometrically towards metabolites used as tumor markers of neuroblastoma.
authors.affiliation: Department of Analytical Chemistry, University of Chemistry and Technology in Prague, 16628 Prague 6, Technická 5, Czech Republic. tatiana.shishkanova@vscht.cz shishkat@yahoo.com kralv@vscht.cz.
authors.forename: T V
authors.initials: TV
authors.lastname: Shishkanova
authors.affiliation: Department of Analytical Chemistry, University of Chemistry and Technology in Prague, 16628 Prague 6, Technická 5, Czech Republic. tatiana.shishkanova@vscht.cz shishkat@yahoo.com kralv@vscht.cz.
authors.forename: M
authors.initials: M
authors.lastname: Havlík
authors.affiliation: Department of Physical Chemistry, University of Chemistry and Technology in Prague, 16628 Prague 6, Technická 5, Czech Republic.
authors.forename: M
authors.initials: M
authors.lastname: Dendisová
authors.affiliation: Department of Physical Chemistry, University of Chemistry and Technology in Prague, 16628 Prague 6, Technická 5, Czech Republic.
authors.forename: P
authors.initials: P
authors.lastname: Matějka
authors.affiliation: Department of Analytical Chemistry, University of Chemistry and Technology in Prague, 16628 Prague 6, Technická 5, Czech Republic. tatiana.shishkanova@vscht.cz shishkat@yahoo.com kralv@vscht.cz.
authors.forename: V
authors.initials: V
authors.lastname: Král