title: The Role of Cardiac Myosin Binding Protein C3 in Hypertrophic Cardiomyopathy-Progress and Novel Therapeutic Opportunities.
abstract: Hypertrophic cardiomyopathy (HCM) is a common autosomal dominant genetic cardiovascular disorder marked by genetic and phenotypic heterogeneity. Mutations in the gene encodes the cardiac myosin-binding protein C, cMYBPC3 is amongst the various sarcomeric genes that are associated with HCM. These mutations produce mutated mRNAs and truncated cMyBP-C proteins. In this review, we will discuss the implications and molecular mechanisms involved in MYBPC3 different mutations. Further, we will highlight the novel targets that can be developed into potential therapeutics for the treatment of HMC. J. Cell. Physiol. 232: 1650-1659, 2017. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Biomedical Science, Zewail City of Science and Technology, Giza, Egypt.
authors.forename: Iman A
authors.initials: IA
authors.lastname: Mohamed
authors.affiliation: Division of Experimental Genetics, Sidra Medical and Research Center, Doha, Qatar.|Heart Science Centre, National Heart and Lung Institute, Imperial College London, London, UK.
authors.forename: Navaneethakrishnan T
authors.initials: NT
authors.lastname: Krishnamoorthy
authors.affiliation: Department of Biomedical Science, College of Health Science, Qatar University, Doha, Qatar.|Biomedical Research Center, Qatar University, Doha, Qatar.
authors.forename: Gheyath K
authors.initials: GK
authors.lastname: Nasrallah
authors.affiliation: Division of Experimental Genetics, Sidra Medical and Research Center, Doha, Qatar.|Department of Biomedical and Biological Sciences, Hamad Bin Khalifa University, Doha, Qatar.
authors.forename: Sahar I
authors.initials: SI
authors.lastname: Da'as
mesh_terms: D000818:Animals; D002312:Cardiomyopathy, Hypertrophic / Q000378:metabolism* / Q000628:therapy*; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D058990:Molecular Targeted Therapy; D009154:Mutation / Q000235:genetics; D009206:Myocardium / Q000378:metabolism*; D000099163:Myosin Binding Protein C
chemical_list: D002352:Carrier Proteins; D000099163:Myosin Binding Protein C