title: Nanohybride Materials Based on Magnetite-Gold Nanoparticles for Diagnostics of Prostate Cancer: Synthesis and In Vitro Testing.
abstract: We synthesized a fluorescence conjugate and modified magnetite-gold nanoparticles carrying prostate specific membrane antigen (PSMA) as the ligand. Analysis of their binding to human prostate cancer cell lines PC-3 (PSMA-) and LNCaP (PSMA+) showed selective interaction of the synthesized conjugate and modified nanoparticles with LNCaP cells. These findings suggest that these nanoparticles can be used in tissue-specific magnetic-resonance imaging.
authors.affiliation: Laboratory of Tissue-Specific Ligands, Faculty of Chemistry, M. V. Lomonosov Moscow State University, Moscow, Russia. alekseymachulkin@rambler.ru.|Laboratory of Biomedical Nanomaterials, National University of Science and Technology, Moscow Institute of Steel and Alloys (NUST MISiS), Moscow, Russia. alekseymachulkin@rambler.ru.
authors.forename: A E
authors.initials: AE
authors.lastname: Machulkin
authors.affiliation: Laboratory of Biomedical Nanomaterials, National University of Science and Technology, Moscow Institute of Steel and Alloys (NUST MISiS), Moscow, Russia.
authors.forename: A S
authors.initials: AS
authors.lastname: Garanina
authors.affiliation: Department of Electronic Microscopy, A. N. Belozersky Research Institute of Physical and Chemical Biology, Moscow, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Zhironkina
authors.affiliation: Laboratory of Tissue-Specific Ligands, Faculty of Chemistry, M. V. Lomonosov Moscow State University, Moscow, Russia.|Laboratory of Biomedical Nanomaterials, National University of Science and Technology, Moscow Institute of Steel and Alloys (NUST MISiS), Moscow, Russia.
authors.forename: E K
authors.initials: EK
authors.lastname: Beloglazkina
authors.affiliation: Laboratory of Tissue-Specific Ligands, Faculty of Chemistry, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Zyk
authors.affiliation: Laboratory of Biomedical Nanomaterials, National University of Science and Technology, Moscow Institute of Steel and Alloys (NUST MISiS), Moscow, Russia.
authors.forename: A G
authors.initials: AG
authors.lastname: Savchenko
authors.affiliation: Laboratory of Tissue-Specific Ligands, Faculty of Chemistry, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: V E
authors.initials: VE
authors.lastname: Kotelyanskii
authors.affiliation: Laboratory of Tissue-Specific Ligands, Faculty of Chemistry, M. V. Lomonosov Moscow State University, Moscow, Russia.|Laboratory of Biomedical Nanomaterials, National University of Science and Technology, Moscow Institute of Steel and Alloys (NUST MISiS), Moscow, Russia.
authors.forename: A G
authors.initials: AG
authors.lastname: Mazhuga
mesh_terms: D045744:Cell Line, Tumor; D003287:Contrast Media / Q000138:chemical synthesis* / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D006046:Gold / Q000737:chemistry; D006801:Humans; D058185:Magnetite Nanoparticles / Q000737:chemistry; D008297:Male; D058726:Nanoconjugates / Q000737:chemistry; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*
chemical_list: D003287:Contrast Media; D058185:Magnetite Nanoparticles; D058726:Nanoconjugates; D006046:Gold
keywords: diagnostics; magnetic-resonance imaging (MRI); nanoparticles; prostate cancer; prostate-specific membrane antigen