title: A bio-inspired enantioselective small-molecule artificial receptor for β adrenergic agonists and antagonists and its application for enantioselective extraction.
abstract: Administration of enantiomerically pure β-adrenergic agonists and antagonists increases their activity and reduces side effects. We report here a small-molecule artificial receptor (SMAR) that, by mimicking the β-adrenergic receptor, is able to enantioselectively extract commercial β-adrenergic interacting drugs. The selectivity is justified according to DFT calculations and X-ray diffraction experiments.
authors.affiliation: Organic Chemistry Department, University of Salamanca, Plaza de los Caídos, 1-5, E-37008, Salamanca, Spain. angelfuentes@usal.es romoran@usal.es.
authors.forename: Ángel L
authors.initials: ÁL
authors.lastname: Fuentes de Arriba
authors.affiliation: Chemical Engineering Department, University of Salamanca, Plaza de los Caídos, 1-5, E-37008, Salamanca, Spain.
authors.forename: Luis
authors.identifier: http://orcid.org/0000-0002-3781-0803
authors.initials: L
authors.lastname: Simón
authors.affiliation: Organic Chemistry Department, University of Salamanca, Plaza de los Caídos, 1-5, E-37008, Salamanca, Spain. angelfuentes@usal.es romoran@usal.es.
authors.forename: Omayra H
authors.initials: OH
authors.lastname: Rubio
authors.affiliation: Organic Chemistry Department, University of Salamanca, Plaza de los Caídos, 1-5, E-37008, Salamanca, Spain. angelfuentes@usal.es romoran@usal.es.
authors.forename: Laura M
authors.initials: LM
authors.lastname: Monleón
authors.affiliation: Industrial Chemistry and Environmental Engineering Department, Technical University of Madrid, Jose Gutierrez Abascal, 2, E-28006, Madrid, Spain.
authors.forename: Victoria
authors.initials: V
authors.lastname: Alcázar
authors.affiliation: X-Ray Diffraction Service, University of Salamanca, Plaza de los Caídos, 1-5, E-37008, Salamanca, Spain.
authors.forename: Francisca
authors.initials: F
authors.lastname: Sanz
authors.affiliation: Mass Spectrometry Service, University of Salamanca, C/ Espejo, s/n, Edificio Multiusos I+D+i, E-37007, Salamanca, Spain.
authors.forename: César A
authors.initials: CA
authors.lastname: Raposo
authors.affiliation: Organic Chemistry Department, University of Salamanca, Plaza de los Caídos, 1-5, E-37008, Salamanca, Spain. angelfuentes@usal.es romoran@usal.es.
authors.forename: Joaquín R
authors.initials: JR
authors.lastname: Morán
mesh_terms: D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D006801:Humans; D011789:Quantum Theory; D011943:Receptors, Adrenergic, beta / Q000737:chemistry*; D062165:Receptors, Artificial / Q000378:metabolism*; D013237:Stereoisomerism
chemical_list: D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta; D062165:Receptors, Artificial