title: Prognostic Value of Plasma D-dimer in Patients with Resectable Esophageal Squamous Cell Carcinoma in China.
abstract: Background:Plasma D-dimer is closely related to prognosis in several cancers. The aim of the current study was to determine the prognostic value of plasma D-dimer in patients with resectable esophageal squamous cell carcinoma (ESCC).Methods:A total of 337 patients with resectable ESCC were enrolled in this retrospective study. The 5-year cancer-specific survival (CSS) was calculated by Kaplan-Meier method. Cox regression analyses were performed to evaluate the prognostic factors. A nomogram model was also performed to predict the cancer prognosis.Results:In our study, there were 242 patients (71.8%) with plasma D-dimer ≤ 0.5 μg/ml and 95 patients (28.2%) with plasma D-dimer > 0.5 μg/ml. There was a significantly better 5-year CSS in patients with plasma D-dimer ≤ 0.5 μg/ml than patients with plasma D-dimer > 0.5 μg/ml (35.5% vs. 21.1%,P< 0.001). Multivariate analyses reported that plasma D-dimer was an independent prognostic factor in patients with resectable ESCC (P< 0.001). In addition, a nomogram was also performed to predict the CSS. The Harrell's c-index was 0.68.Conclusion:We conclude that plasma D-dimer was an independent prognostic biomarker in patients with resectable ESCC.
authors.affiliation: Department of Thoracic Surgery, Zhejiang Cancer Hospital, Hangzhou, China.
authors.forename: Ji-Feng
authors.initials: JF
authors.lastname: Feng
authors.affiliation: Department of Thoracic Surgery, Zhejiang Cancer Hospital, Hangzhou, China.
authors.forename: Xun
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Thoracic Surgery, Zhejiang Cancer Hospital, Hangzhou, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Thoracic Surgery, Zhejiang Cancer Hospital, Hangzhou, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Thoracic Surgery, Zhejiang Cancer Hospital, Hangzhou, China.
authors.forename: Qi-Xun
authors.initials: QX
authors.lastname: Chen
keywords: biomarker; plasma D-dimer