title: Correlation of VCAM-1 expression in serum, cord blood, and placental tissue with gestational hypertension associated with fetal growth restriction in women from Xingtai Hebei, China.
abstract: The aim of this study was to investigate the expression of vascular adhesion molecule (VCAM)-1 in the maternal serum, cord blood, and placental tissue of pregnant women from Xingtai, Hebei, with gestational hypertension (GH) combined with fetal growth restriction (FGR). A total of 108 patients with GH combined with FGR (GH-FGR), 60 patients with GH alone (GH), and 50 healthy pregnant women (control) were recruited to this study. VCAM- 1 expression was detected in the maternal serum and cord blood by enzyme-linked immunosorbent assay, and in the placental tissue by immunohistochemistry. VCAM-1 expression was significantly higher in the maternal serum of patients with GH-FGR (164.38 ± 60.35) and GH alone (103.85 ± 54.47) than in the serum of the control population (46.70 ± 21.79; P < 0.05). On the other hand, VCAM-1 expression in the cord blood of GH-FGR (163.19 ± 69.46), GH (149.82 ± 58.20), and control (128.89 ± 43.59) subjects was not significantly different (P > 0.05). Moreover, the VCAM-1 expression rates were significantly higher and lower in the vascular endothelial and trophoblastic cells of the placenta of patients with GH-FGR (74.71 and 56.1%) and GH (72.98 and 55.36%), respectively, compared to those in the control subjects (46.48 and 95.11%). Therefore, we concluded that VCAM- 1 plays an important role in the development and generation of GH. Additionally, the low VCAM-1 expression in the trophoblastic cell could be correlated to the pathogenesis and progression of GH.
authors.affiliation: Department of Neonatology, Affiliated Xingtai People's Hospital of Hebei Medical University, Xingtai, Hebei, China.
authors.forename: H G
authors.initials: HG
authors.lastname: Zhang
authors.affiliation: Department of Neonatology, Affiliated Xingtai People's Hospital of Hebei Medical University, Xingtai, Hebei, China guowei_xt@126.com.
authors.forename: W
authors.initials: W
authors.lastname: Guo
authors.affiliation: Department of Neonatology, Affiliated Xingtai People's Hospital of Hebei Medical University, Xingtai, Hebei, China.
authors.forename: H F
authors.initials: HF
authors.lastname: Gu
authors.affiliation: Department of Radiology, Affiliated Xingtai People's Hospital of Hebei Medical University, Xingtai, Hebei, China.
authors.forename: S B
authors.initials: SB
authors.lastname: Chen
authors.affiliation: Department of Neonatology, Affiliated Xingtai People's Hospital of Hebei Medical University, Xingtai, Hebei, China.
authors.forename: J Q
authors.initials: JQ
authors.lastname: Wang
authors.affiliation: Obstetric, Affiliated Xingtai People's Hospital of Hebei Medical University, Xingtai, Hebei, China.
authors.forename: Z X
authors.initials: ZX
authors.lastname: Qiao
authors.affiliation: Obstetric, Affiliated Xingtai People's Hospital of Hebei Medical University, Xingtai, Hebei, China.
authors.forename: H S
authors.initials: HS
authors.lastname: Ma
authors.affiliation: Department of Neonatology, Affiliated Xingtai People's Hospital of Hebei Medical University, Xingtai, Hebei, China.
authors.forename: S X
authors.initials: SX
authors.lastname: Geng
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D042783:Endothelial Cells / Q000737:chemistry / Q000378:metabolism; D005260:Female; D005312:Fetal Blood / Q000737:chemistry / Q000378:metabolism; D005317:Fetal Growth Retardation / Q000097:blood / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D005333:Fetus; D015870:Gene Expression; D005865:Gestational Age; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D011247:Pregnancy; D014327:Trophoblasts / Q000737:chemistry / Q000378:metabolism; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood / Q000235:genetics*
chemical_list: D019010:Vascular Cell Adhesion Molecule-1