title: Metastatic malignant melanoma of the urinary bladder: A case report and review of the literature.
abstract: Metastatic bladder tumors constitute <5% of all bladder tumors and metastatic malignant melanoma of the urinary bladder is very rare. We present a case report of a metastatic malignant melanoma of the urinary bladder. A 70-year-old woman without any apparent significant clinical history was admitted to the Department of Urology for gross hematuria. Microscopic findings of the transurethral resection specimen revealed fascicles, sheets, and diffuse areas composed of oval and fusiform cells with focal pigmentation. Immunohistochemical analysis revealed that the tumor cells were positive for human melanoma black-45, Melan-A, and S100, and negative for pancytokeratin. Subsequently, we contacted the patient and learned that she was admitted to the Department of Ophthalmology for painless and progressive visual field loss 15 years ago. She had been diagnosed with a primary ocular (uveal) melanoma. A detailed patient history coupled with histological and immunohistochemical findings were necessary to make the final diagnosis of metastatic melanoma.
authors.affiliation: Department of Pathology, Umraniye Education and Research Hospital, Istanbul, Turkey.
authors.forename: Cumhur Selcuk
authors.initials: CS
authors.lastname: Topal
authors.affiliation: Department of Pathology, Umraniye Education and Research Hospital, Istanbul, Turkey.
authors.forename: Gözde
authors.initials: G
authors.lastname: Kır
authors.affiliation: Department of Pathology, The Ministry of Justice Forensic Council of Turkey, Istanbul, Turkey.
authors.forename: Taner
authors.initials: T
authors.lastname: Daş
authors.affiliation: Department of Pathology, Denizli State Hospital, Denizli, Turkey.
authors.forename: Billur
authors.initials: B
authors.lastname: Sarbay
authors.affiliation: Department of Pathology, Umraniye Education and Research Hospital, Istanbul, Turkey.
authors.forename: Muzaffer İlkay
authors.initials: Mİ
authors.lastname: Tosun
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006417:Hematuria / Q000175:diagnosis / Q000209:etiology; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D058965:MART-1 Antigen / Q000032:analysis; D008545:Melanoma / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D008853:Microscopy; D009418:S100 Proteins / Q000032:analysis; D014057:Tomography, X-Ray Computed; D001743:Urinary Bladder / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D014604:Uveal Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D000098943:Uveal Melanoma
chemical_list: D014408:Biomarkers, Tumor; D058965:MART-1 Antigen; C548667:MLANA protein, human; D009418:S100 Proteins; D007633:Keratins