title: Identification of the key structural elements of a dihydropyrimidinone core driving toward more potent Hsp90 C-terminal inhibitors.
abstract: Hsp90 C-terminal modulation represents an attractive strategy for the development of potent and safer antitumor compounds. Continuing our investigation on DHPM type inhibitors here we report a new set of potent C-terminal ligands which allowed us to identify the key structural features crucial for the biological activity.
authors.forename: S
authors.initials: S
authors.lastname: Terracciano
authors.affiliation: Department of Pharmacy, University of Salerno, via Giovanni Paolo II, 132, 84084, Fisciano, Italy. bifulco@unisa.it brunoin@unisa.it.
authors.forename: M G
authors.initials: MG
authors.lastname: Chini
authors.affiliation: Department of Pharmacy, University of Salerno, via Giovanni Paolo II, 132, 84084, Fisciano, Italy. bifulco@unisa.it brunoin@unisa.it.
authors.forename: M C
authors.initials: MC
authors.lastname: Vaccaro
authors.affiliation: Department of Pharmacy, University of Salerno, via Giovanni Paolo II, 132, 84084, Fisciano, Italy. bifulco@unisa.it brunoin@unisa.it.
authors.forename: M
authors.initials: M
authors.lastname: Strocchia
authors.affiliation: Department of Pharmacy, University of Salerno, via Giovanni Paolo II, 132, 84084, Fisciano, Italy. bifulco@unisa.it brunoin@unisa.it.
authors.forename: A
authors.initials: A
authors.lastname: Foglia
authors.affiliation: Department of Science, University of Basilicata, Viale dell'Ateneo Lucano n.10, 85100 Potenza, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Vassallo
authors.affiliation: Department of Pharmacy, University of Salerno, via Giovanni Paolo II, 132, 84084, Fisciano, Italy. bifulco@unisa.it brunoin@unisa.it.
authors.forename: C
authors.initials: C
authors.lastname: Saturnino
authors.affiliation: Department of Pharmacy, University of Salerno, via Giovanni Paolo II, 132, 84084, Fisciano, Italy. bifulco@unisa.it brunoin@unisa.it.
authors.forename: R
authors.initials: R
authors.lastname: Riccio
authors.affiliation: Department of Pharmacy, University of Salerno, via Giovanni Paolo II, 132, 84084, Fisciano, Italy. bifulco@unisa.it brunoin@unisa.it.
authors.forename: G
authors.initials: G
authors.lastname: Bifulco
authors.affiliation: Department of Pharmacy, University of Salerno, via Giovanni Paolo II, 132, 84084, Fisciano, Italy. bifulco@unisa.it brunoin@unisa.it.
authors.forename: I
authors.initials: I
authors.lastname: Bruno