title: NMR-based metabonomics and correlation analysis reveal potential biomarkers associated with chronic atrophic gastritis.
abstract: Chronic atrophic gastritis (CAG) is one of the most important pre-cancerous states with a high prevalence. Exploring of the underlying mechanism and potential biomarkers is of significant importance for CAG. In the present work,1H NMR-based metabonomics with correlative analysis was performed to analyze the metabolic features of CAG. 19 plasma metabolites and 18 urine metabolites were enrolled to construct the circulatory and excretory metabolome of CAG, which was in response to alterations of energy metabolism, inflammation, immune dysfunction, as well as oxidative stress. 7 plasma biomarkers and 7 urine biomarkers were screened to elucidate the pathogenesis of CAG based on the further correlation analysis with biochemical indexes. Finally, 3 plasma biomarkers (arginine, succinate and 3-hydroxybutyrate) and 2 urine biomarkers (α-ketoglutarate and valine) highlighted the potential to indicate risks of CAG in virtue of correlation with pepsin activity and ROC analysis. Here, our results paved a way for elucidating the underlying mechanisms in the development of CAG, and provided new avenues for the diagnosis of CAG and presented potential drug targets for treatment of CAG.
authors.affiliation: Modern Research Center for Traditional Chinese Medicine of Shanxi University, No. 92, Wucheng Road, Taiyuan 030006, Shanxi, PR China.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Cui
authors.affiliation: Modern Research Center for Traditional Chinese Medicine of Shanxi University, No. 92, Wucheng Road, Taiyuan 030006, Shanxi, PR China. Electronic address: yuetaoliu@sxu.edu.cn.
authors.forename: Yuetao
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Modern Research Center for Traditional Chinese Medicine of Shanxi University, No. 92, Wucheng Road, Taiyuan 030006, Shanxi, PR China; College of Chemistry and Chemical Engineering of Shanxi University, No. 92, Wucheng Road, Taiyuan 030006, Shanxi, PR China.
authors.forename: Yinghuan
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Modern Research Center for Traditional Chinese Medicine of Shanxi University, No. 92, Wucheng Road, Taiyuan 030006, Shanxi, PR China; College of Chemistry and Chemical Engineering of Shanxi University, No. 92, Wucheng Road, Taiyuan 030006, Shanxi, PR China.
authors.forename: Jiayu
authors.initials: J
authors.lastname: Tong
authors.affiliation: Modern Research Center for Traditional Chinese Medicine of Shanxi University, No. 92, Wucheng Road, Taiyuan 030006, Shanxi, PR China.
authors.forename: Aiping
authors.initials: A
authors.lastname: Li
authors.affiliation: School of Pharmaceutical Science of Shanxi Medical University, No. 56, Xinjian South Road, Taiyuan 030001, Shanxi, PR China.
authors.forename: Tingli
authors.initials: T
authors.lastname: Qu
authors.affiliation: Modern Research Center for Traditional Chinese Medicine of Shanxi University, No. 92, Wucheng Road, Taiyuan 030006, Shanxi, PR China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Qin
authors.affiliation: Modern Research Center for Traditional Chinese Medicine of Shanxi University, No. 92, Wucheng Road, Taiyuan 030006, Shanxi, PR China; Institute of Material Medical, Chinese Academy of Medical Sciences, Beijing 100050, PR China. Electronic address: dugh@imm.ac.cn.
authors.forename: Guanhua
authors.initials: G
authors.lastname: Du
mesh_terms: D020155:3-Hydroxybutyric Acid / Q000378:metabolism; D000818:Animals; D001120:Arginine / Q000737:chemistry; D015415:Biomarkers / Q000378:metabolism* / Q000652:urine; D001835:Body Weight; D002908:Chronic Disease; D018450:Disease Progression; D005227:Fatty Acids / Q000378:metabolism; D005757:Gastritis, Atrophic / Q000378:metabolism* / Q000652:urine; D005947:Glucose / Q000378:metabolism; D007107:Immune System; D007249:Inflammation; D007413:Intestinal Mucosa / Q000378:metabolism; D007656:Ketoglutaric Acids / Q000378:metabolism; D008055:Lipids / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D055432:Metabolomics / Q000379:methods*; D015999:Multivariate Analysis; D018384:Oxidative Stress; D010434:Pepsin A / Q000737:chemistry; D011392:Proline / Q000737:chemistry; D012372:ROC Curve; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D015415:Biomarkers; D005227:Fatty Acids; D007656:Ketoglutaric Acids; D008055:Lipids; D001120:Arginine; D011392:Proline; D010434:Pepsin A; D005947:Glucose; D020155:3-Hydroxybutyric Acid
keywords: Biomarkers; Chronic atrophic gastritis; Correlation analysis; Metabonomics; NMR