title: Resveratrol: An Antiaging Drug with Potential Therapeutic Applications in Treating Diseases.
abstract: The prevention of aging is one of the most fascinating areas in biomedicine. The first step in the development of effective drugs for aging prevention is a knowledge of the biochemical pathways responsible for the cellular aging process. In this context it seems clear that free radicals play a key role in the aging process. However, in recent years it has been demonstrated that the families of enzymes called sirtuins, specifically situin 1 (SIRT1), have an anti-aging action. Thus, the natural compound resveratrol is a natural compound that shows a very strong activation of SIRT1 and also shows antioxidant effects. By activating sirtuin 1, resveratrol modulates the activity of numerous proteins, including peroxisome proliferator-activated receptor coactivator-1α (PGC-1 alpha), the FOXO family, Akt (protein kinase B) and NFκβ. In the present review, we suggest that resveratrol may constitute a potential drug for prevention of ageing and for the treatment of several diseases due to its antioxidant properties and sirtuin activation.
authors.affiliation: Unitat de Farmacologia i Farmacognòsia i Institut de Biomedicina (IBUB), Centro de Investigación de Biomedicina en Red de Enfermedades Neurodegenerativas (CIBERNED), Facultat de Farmàcia, Universitat de Barcelona, 08028 Barcelona, Spain. camins@ub.edu.
authors.forename: Antoni
authors.initials: A
authors.lastname: Camins
authors.affiliation: Unitat de Farmacologia i Farmacognòsia i Institut de Biomedicina (IBUB), Centro de Investigación de Biomedicina en Red de Enfermedades Neurodegenerativas (CIBERNED), Facultat de Farmàcia, Universitat de Barcelona, 08028 Barcelona, Spain.
authors.forename: Felix
authors.initials: F
authors.lastname: Junyent
authors.affiliation: Unitat de Farmacologia i Farmacognòsia i Institut de Biomedicina (IBUB), Centro de Investigación de Biomedicina en Red de Enfermedades Neurodegenerativas (CIBERNED), Facultat de Farmàcia, Universitat de Barcelona, 08028 Barcelona, Spain.
authors.forename: Ester
authors.initials: E
authors.lastname: Verdaguer
authors.affiliation: Departamento de Biología Celular y Molecular, CUCBA, Universidad de Guadalajara, División de Neurociencias, Centro de Investigación Biomédica de Occidente, IMSS, Sierra Mojada 800, Col. Independencia, Guadalajara, Jalisco 44340, Mexico.
authors.forename: Carlos
authors.initials: C
authors.lastname: Beas-Zarate
authors.affiliation: UMR 975 INSERM, Thérapeutique Expérimentale de la neurodégénérescence, Centre de recherche de l'Institut du cerveau et de la moelle épiniére (CRICM), Université Pierre et Marie Curie, Hôpital de la Salpêtrière, Paris, France.
authors.forename: Argelia E
authors.initials: AE
authors.lastname: Rojas-Mayorquín
authors.affiliation: Laboratorio de Desarrollo y Regeneración Neural, Instituto de Neurobiología, Departamento de Biología Celular y Molecular, C.U.C.B.A, Universidad de Guadalajara, Guadalajara, Jalisco, México.
authors.forename: Daniel
authors.initials: D
authors.lastname: Ortuño-Sahagún
authors.affiliation: Unitat de Farmacologia i Farmacognòsia i Institut de Biomedicina (IBUB), Centro de Investigación de Biomedicina en Red de Enfermedades Neurodegenerativas (CIBERNED), Facultat de Farmàcia, Universitat de Barcelona, 08028 Barcelona, Spain.
authors.forename: Mercè
authors.initials: M
authors.lastname: Pallàs
keywords: Alzheimer’s disease; Parkinson’s disease; SIRT1; resveratrol