title: Associations between Long-Term Particulate Matter Exposure and Adult Renal Function in the Taipei Metropolis.
abstract: Studies on the effect of air pollutions on kidney diseases are still limited.
  
  
  
  We aimed to investigate the associations between particulate matter (PM) exposures and renal function among adults.
  
  
  
  We recruited 21,656 adults as participants from 2007 to 2009. The Taiwanese Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation was used to derive the estimated glomerular filtration rate (eGFR). Subjects with an eGFR lower than 60 mL/min/1.73 m2were defined as having chronic kidney disease (CKD). Land use regression (LUR) models were used to estimate individual exposures to PM with an aerodynamic diameter < 10 μm (PM10), coarse particles (PMCoarse), fine particles (PM2.5), and PM2.5Absorbance. Generalized linear and logistic regression models were used to estimate the associations between PM exposure and renal function.
  
  
  
  An IQR increase in PM10(5.83 μg/m3) was negatively associated with eGFR by -0.69 (95% CI: -0.89, -0.48) mL/min/1.73 m2and positively associated with the prevalence of CKD with adjusted OR = 1.15 (95% CI: 1.07, 1.23). An IQR increase in PMCoarse(6.59 μg/m3) was significantly associated with lower eGFR by -1.07 (95% CI: -1.32, -0.81) mL/min/1.73 m2and CKD with OR = 1.26 (95% CI: 1.15, 1.38). In contrast, neither outcome was significantly associated with PM2.5or PM2.5Absorbance. Stratified analyses indicated that associations of CKD with both PM10and PMCoarsewere limited to participants < 65 years of age, and were stronger (for PM10) or limited to (PMCoarse) women. Associations also appeared to be stronger in those without (vs. with) hypertension, and in normal versus overweight participants.
  
  
  
  Exposure during the previous year to PM10and PMCoarse, but not PM2.5or PM2.5Absorbance, was associated with reduced renal function among Taiwanese adults.
authors.affiliation: Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan.
authors.forename: Ya-Ru
authors.initials: YR
authors.lastname: Yang
authors.forename: Yung-Ming
authors.initials: YM
authors.lastname: Chen
authors.forename: Szu-Ying
authors.initials: SY
authors.lastname: Chen
authors.forename: Chang-Chuan
authors.initials: CC
authors.lastname: Chan
mesh_terms: D000393:Air Pollutants / Q000032:analysis; D000397:Air Pollution / Q000706:statistics & numerical data*; D004781:Environmental Exposure / Q000706:statistics & numerical data*; D006801:Humans; D016015:Logistic Models; D008962:Models, Theoretical; D052638:Particulate Matter / Q000032:analysis*; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology*; D013624:Taiwan / Q000453:epidemiology
chemical_list: D000393:Air Pollutants; D052638:Particulate Matter