title: Vestibular schwannomas treated with Cyberknife®: clinical outcomes.
abstract: OBJECTIVE
  Fractionated stereotactic radiotherapy (FSR) is a recognized treatment for vestibular schwannomas (VS). This study's aim is to present clinical outcomes and local control (LC) results for patients with VS treated with FSR using the Cyberknife® (CK) in 2 French cancer centers.
  
  
  METHODS
  Patients treated with FSR for VS between 2007 and 2012 were retrospectively analyzed. Local control was determined using follow-up MRI. The hearing preservation (HP) rate was determined by analyzing pretreatment and posttreatment audiograms.
  
  
  RESULTS
  Forty patients were treated for VS with the CK in both centers. The mean maximal VS dimension was 18.3 mm (range 3-30). The median follow-up was 36 months and the LC was 97% at 3 years of follow-up and 89% after 5 years. The HP rate was 83% and no facial nerve impairment was reported.
  
  
  CONCLUSIONS
  Our results in terms of LC and HP rate are congruent with similar studies that use the CK to treat VS. It appears that the CK is safe and efficient in VS management even for large lesions. Further studies with larger cohorts are warranted.
authors.affiliation: Department of Radiotherapy, Institut de Cancérologie de Lorraine, Vandoeuvre-les-Nancy - France.
authors.forename: Raphaël
authors.initials: R
authors.lastname: Jumeau
authors.affiliation: Department of Radiotherapy, Centre Antoine Lacassagne, Nice - France.
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Bondiau
authors.affiliation: Department of Otorhinolaryngology, Nancy University Hospital, Nancy - France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Parietti-Winkler
authors.affiliation: Department of Statistics, Institut de Cancérologie de Lorraine, Vandoeuvre-les-Nancy - France.
authors.forename: Julia
authors.initials: J
authors.lastname: Salleron
authors.affiliation: Department of Neurosurgery, Nancy University Hospital, Nancy - France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Civit
authors.affiliation: Department of Radiotherapy, Institut de Cancérologie de Lorraine, Vandoeuvre-les-Nancy - France.
authors.forename: Didier
authors.initials: D
authors.lastname: Peiffert
authors.affiliation: Department of Radiotherapy, Institut de Cancérologie de Lorraine, Vandoeuvre-les-Nancy - France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Bernier-Chastagner
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D019583:Dose Fractionation, Radiation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D000072232:Radiation Dosimeters; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D012189:Retrospective Studies; D016896:Treatment Outcome; D047368:Tumor Burden; D055815:Young Adult