title: Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine.
abstract: Three thermally and hydrolytically stable silylamide trioxanes have been prepared from the natural trioxane artemisinin in only five simple chemical steps and in at least 56% overall yield. Two of these new chemical entities completely cured malariainfected mice at a single oral dose of only 8 mg/kg combined with 24 mg/kg of mefloquine hydrochloride. The high efficacy of this ACT chemotherapy is considerably better than the efficacy using the popular trioxane drug artemether plus mefloquine hydrochloride.
authors.affiliation: Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218-2685, MD, USA. lwoodar1@jhu.edu.
authors.forename: Lauren E
authors.initials: LE
authors.lastname: Woodard
authors.affiliation: Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218-2685, MD, USA. bmott2@jhu.edu.
authors.forename: Bryan T
authors.initials: BT
authors.lastname: Mott
authors.affiliation: Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Baltimore, MD 21205, USA. vsinghal@jhsph.edu.
authors.forename: Vandana
authors.initials: V
authors.lastname: Singhal
authors.affiliation: Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Baltimore, MD 21205, USA. nkumar@jhsph.edu.
authors.forename: Nirbhay
authors.initials: N
authors.lastname: Kumar
authors.affiliation: Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Baltimore, MD 21205, USA. tshapiro@jhmi.edu.|Division of Clinical Pharmacology, Department of Medicine, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA. tshapiro@jhmi.edu.
authors.forename: Theresa A
authors.initials: TA
authors.lastname: Shapiro
authors.affiliation: Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218-2685, MD, USA. ghp@jhu.edu.|Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Baltimore, MD 21205, USA. ghp@jhu.edu.
authors.forename: Gary H
authors.initials: GH
authors.lastname: Posner
keywords: antimalarial monomers and dimmers; silylamide trioxanes; single dose oral cure