title: Genetic and Epigenetic Components of Aspirin-Exacerbated Respiratory Disease.
abstract: Aspirin-exacerbated respiratory disease (AERD) severity and its clinical phenotypes are characterized by genetic variation within pathways for arachidonic acid metabolism, inflammation, and immune responses. Epigenetic effects, including DNA methylation and histone protein modification, contribute to regulation of many genes that contribute to inflammatory states in AERD. The development of noninvasive, predictive clinical tests using data from genetic, epigenetic, pharmacogenetic, and biomarker studies will improve precision medicine efforts for AERD and asthma treatment.
authors.affiliation: Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.
authors.forename: Amber
authors.initials: A
authors.lastname: Dahlin
authors.affiliation: Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA. Electronic address: scott.weiss@channing.harvard.edu.
authors.forename: Scott T
authors.initials: ST
authors.lastname: Weiss
mesh_terms: D000483:Alleles; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D015415:Biomarkers; D019468:Disease Management; D004804:Eosinophils / Q000276:immunology / Q000378:metabolism; D044127:Epigenesis, Genetic; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D011110:Polymorphism, Genetic; D040641:Quantitative Trait Loci; D012140:Respiratory Tract Diseases / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism / Q000628:therapy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D015415:Biomarkers; D001241:Aspirin
keywords: AERD; Biomarker; Cysteinyl leukotriene; Eosinophil; Epigenetics; Polymorphism