title: Shigella Vaccine Development: Finding the Path of Least Resistance.
abstract: Shigella spp. represent the second most common etiologic pathogen causing childhood diarrhea in developing countries. There are no licensed Shigella vaccines, and progress for such vaccines has been limited. In this issue of Clinical and Vaccine Immunology, Riddle and colleagues (M. S. Riddle, R. W. Kaminski, C. Di Paolo, C. K. Porter, R. L. Gutierrez, et al., Clin Vaccine Immunol 23:908-917, 2016, http://dx.doi.org/10.1128/CVI.00224-16) report results from a phase I study of a parenterally administered monovalent O-polysaccharide "bioconjugate" directed against Shigella flexneri 2a. Ultimately, the goal is to develop a broad-spectrum Shigella vaccine to address this public health concern. A parenteral Shigella vaccine capable of eliciting protection in children of developing countries would be an important tool to reach this goal.
authors.affiliation: Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA wchen@medicine.umaryland.edu.|Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA.
authors.forename: Wilbur H
authors.identifier: http://orcid.org/0000-0001-7741-5536
authors.initials: WH
authors.lastname: Chen
authors.affiliation: Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.|Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA.|Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA.
authors.forename: Karen L
authors.initials: KL
authors.lastname: Kotloff
mesh_terms: D002648:Child; D003906:Developing Countries; D003967:Diarrhea / Q000382:microbiology; D055808:Drug Discovery; D004405:Dysentery, Bacillary / Q000517:prevention & control*; D006801:Humans; D022281:Shigella Vaccines / Q000276:immunology*; D012763:Shigella flexneri / Q000276:immunology; D012764:Shigella sonnei / Q000276:immunology
chemical_list: D022281:Shigella Vaccines