title: Regulating Stem Cell Secretome Using Injectable Hydrogels with In Situ Network Formation.
abstract: A family of shear-thinning hydrogels for injectable encapsulation and long-term delivery (SHIELD) has been designed and synthesized with controlled in situ stiffening properties to regulate the stem cell secretome. The authors demonstrate that SHIELD with an intermediate stiffness (200-400 Pa) could significantly promote the angiogenic potential of human adipose-derived stem cells.
authors.affiliation: Department of Materials Science and Engineering, Stanford Neuroscience Institute, Stanford University, Stanford, CA, 94305, USA.
authors.forename: Lei
authors.initials: L
authors.lastname: Cai
authors.affiliation: Department of Materials Science and Engineering, Stanford University, Stanford, CA, 94305, USA.
authors.forename: Ruby E
authors.initials: RE
authors.lastname: Dewi
authors.affiliation: Department of Cardiothoracic Surgery, Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA.
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Goldstone
authors.affiliation: Department of Cardiothoracic Surgery, Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA.
authors.forename: Jeffrey E
authors.initials: JE
authors.lastname: Cohen
authors.affiliation: Department of Cardiothoracic Surgery, Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA.
authors.forename: Amanda N
authors.initials: AN
authors.lastname: Steele
authors.affiliation: Department of Cardiothoracic Surgery, Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA.
authors.forename: Y Joseph
authors.initials: YJ
authors.lastname: Woo
authors.affiliation: Department of Materials Science and Engineering, Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA.
authors.forename: Sarah C
authors.initials: SC
authors.lastname: Heilshorn
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D002478:Cells, Cultured; D006801:Humans; D020100:Hydrogels / Q000494:pharmacology*; D007267:Injections / Q000379:methods; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D012212:Rheology; D013234:Stem Cells / Q000187:drug effects* / Q000378:metabolism
chemical_list: D020100:Hydrogels; D036341:Intercellular Signaling Peptides and Proteins
keywords: angiogenic function; injectable hydrogels; molecular recognition; reinforcing network; stem cell secretome