title: Zika Virus: The Agent and Its Biology, With Relevance to Pathology.
abstract: Once obscure, Zika virus (ZIKV) has attracted significant medical and scientific attention in the past year because of large outbreaks associated with the recent introduction of this virus into the Western hemisphere. In particular, the occurrence of severe congenital infections and cases of Guillain-Barré syndrome has placed this virus squarely in the eyes of clinical and anatomic pathologists. This review article provides a basic introduction to ZIKV, its genetics, its structural characteristics, and its biology. A multidisciplinary effort will be essential to establish clinicopathologic correlations of the basic virology of ZIKV in order to advance development of diagnostics, therapeutics, and vaccines.
authors.forename: Carey L
authors.initials: CL
authors.lastname: Medin
authors.affiliation: From the Institute for Immunology and Informatics, Department of Cell and Molecular Biology, University of Rhode Island, Providence. Drs Medin and Rothman both contributed equally to the manuscript.
authors.forename: Alan L
authors.initials: AL
authors.lastname: Rothman
mesh_terms: D001938:Brazil / Q000453:epidemiology; D004196:Disease Outbreaks; D016679:Genome, Viral / Q000235:genetics; D020275:Guillain-Barre Syndrome / Q000150:complications / Q000453:epidemiology; D006801:Humans; D008831:Microcephaly / Q000150:complications / Q000453:epidemiology; D011114:Polynesia / Q000453:epidemiology; D014454:Uganda / Q000453:epidemiology; D000071244:Zika Virus / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D000071243:Zika Virus Infection / Q000150:complications / Q000453:epidemiology* / Q000821:virology*