title: Clinical Profile of Patients with Necrotizing Scleritis in a Tertiary Eye Care Center in Southern India.
abstract: OBJECTIVE
  To report the clinical profile of a series of necrotizing scleritis in an Indian population.
  
  
  METHODS
  A retrospective medical record review of 27 consecutive patients with necrotizing scleritis. Patient demographics, ocular and systemic findings, treatment modalities, and visual outcome were recorded.
  
  
  RESULTS
  There were 19 males and 8 females (31 eyes) with mean age at presentation of 49.5 years (range: 30-84 years). Underlying immunologically induced disorders was present in 37%. In 70% of the cases with immunologically induced disorders, necrotizing scleritis was the initial presentation. Complicated cataract (25.8%) and exudative retinal detachment (9.6%) were the most common anterior and posterior segment complications, respectively. Cyclophosphamide was the most commonly used immunosuppressive (55.56%) and proved to be the most effective. But even with the best available treatment, globe perforation was encountered in two eyes.
  
  
  CONCLUSIONS
  Necrotizing scleritis can be the initial presentation of immunologically induced disorders. This disease entity is plagued with a high rate of ocular complications, especially those which can be devastating, such as globe perforation. Early and intensive therapy can be helpful in salvaging the eye.
authors.affiliation: a Department of Uvea, Sankara Nethralaya , Nungambakkam , Chennai , India.
authors.forename: Parthopratim
authors.initials: P
authors.lastname: Dutta Majumder
authors.affiliation: b Uvea and Medical Retina Department, Sankara Nethralaya , Mukundapur , Kolkata , India.
authors.forename: Avirupa
authors.initials: A
authors.lastname: Ghose
authors.affiliation: c Sankara Nethralaya , Chennai , India.
authors.forename: Meenakshi
authors.initials: M
authors.lastname: Chidambaram
authors.affiliation: a Department of Uvea, Sankara Nethralaya , Nungambakkam , Chennai , India.
authors.forename: Sudha K
authors.initials: SK
authors.lastname: Ganesh
authors.affiliation: a Department of Uvea, Sankara Nethralaya , Nungambakkam , Chennai , India.
authors.forename: Jyotirmay
authors.initials: J
authors.lastname: Biswas
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015423:Scleritis / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology*; D062606:Tertiary Care Centers / Q000706:statistics & numerical data; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide
keywords: Clinical profile; immunologically induced disorders; inflammatory; necrotizing scleritis; schleral necrosis