title: Ligandless Nickel-Catalyzed Ortho-Selective Directed Trifluoromethylthiolation of Aryl Chlorides and Bromides Using AgSCF3.
abstract: A mild protocol for Ni-catalyzed trifluoromethylthiolation of aryl chlorides and bromides is described herein. The method utilizes AgSCF3as an easily accessible nucleophilic trifluoromethylthiolating reagent and does not require any ligands or additives. Ortho-selectivity is achieved using a variety of directing groups such as imines, pyridines, and oxazolines for 24 examples in up to 95% yield.
authors.affiliation: Department of Chemistry, The University of British Columbia , Vancouver, British Columbia V6T 1Z1, Canada.
authors.forename: Tin
authors.initials: T
authors.lastname: Nguyen
authors.affiliation: Department of Chemistry, The University of British Columbia , Vancouver, British Columbia V6T 1Z1, Canada.
authors.forename: Weiling
authors.initials: W
authors.lastname: Chiu
authors.affiliation: Department of Chemistry, The University of British Columbia , Vancouver, British Columbia V6T 1Z1, Canada.
authors.forename: Xinying
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Chemistry, The University of British Columbia , Vancouver, British Columbia V6T 1Z1, Canada.
authors.forename: Madeleine O
authors.initials: MO
authors.lastname: Sattler
authors.affiliation: Department of Chemistry, The University of British Columbia , Vancouver, British Columbia V6T 1Z1, Canada.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Love