title: OpenZika: An IBM World Community Grid Project to Accelerate Zika Virus Drug Discovery.
abstract: The Zika virus outbreak in the Americas has caused global concern. To help accelerate this fight against Zika, we launched the OpenZika project. OpenZika is an IBM World Community Grid Project that uses distributed computing on millions of computers and Android devices to run docking experiments, in order to dock tens of millions of drug-like compounds against crystal structures and homology models of Zika proteins (and other related flavivirus targets). This will enable the identification of new candidates that can then be tested in vitro, to advance the discovery and development of new antiviral drugs against the Zika virus. The docking data is being made openly accessible so that all members of the global research community can use it to further advance drug discovery studies against Zika and other related flaviviruses.
authors.affiliation: Collaborations Pharmaceuticals, Inc., Fuquay-Varina, North Carolina, United States of America.
authors.forename: Sean
authors.identifier: http://orcid.org/0000-0002-5691-5790
authors.initials: S
authors.lastname: Ekins
authors.affiliation: Department of Pharmacology, Physiology and Neuroscience, Rutgers University New Jersey Medical School, Newark, New Jersey, United States of America.
authors.forename: Alexander L
authors.initials: AL
authors.lastname: Perryman
authors.affiliation: LabMol Laboratory for Molecular Modeling and Drug Design, Faculdade de Farmácia, Universidade Fedral de Goiás, Goiânia, Goiás, Brazil.
authors.forename: Carolina
authors.initials: C
authors.lastname: Horta Andrade
mesh_terms: D000569:Americas / Q000453:epidemiology; D000998:Antiviral Agents; D004196:Disease Outbreaks / Q000517:prevention & control; D015195:Drug Design; D055808:Drug Discovery; D004345:Drug Industry; D006801:Humans; D062105:Molecular Docking Simulation; D000071220:Pharmaceutical Research; D014944:World Health Organization; D000071244:Zika Virus / Q000737:chemistry / Q000187:drug effects*; D000071243:Zika Virus Infection / Q000188:drug therapy* / Q000453:epidemiology / Q000517:prevention & control / Q000821:virology
chemical_list: D000998:Antiviral Agents