title: [Insulin edema in hepatic glycogenosis].
abstract: BACKGROUND
  Hepatic glycogenosis is a rare syndrome, which includes poorly controlled diabetes mellitus, hepatomegaly, delayed puberty, and growth delay. Insulin edema is sometimes associated.
  
  
  METHODS
  An 18-year-old woman presented with diffuse edema, hepatomegaly, amenorrhea, uncontrolled diabetes, and elevated transaminases and cholestasis. Hepatic ultrasonography and abdominal computed tomographic scan confirmed the hepatomegaly. The liver biopsy showed a massive glycogenosis and the diagnosis of hepatic glycogenosis was confirmed. Too large doses of insulin were responsible of diffuse edema. Diabetes equilibration and diminution of insulin intakes allow correction of this disorder.
  
  
  CONCLUSIONS
  Excess of insulin can lead to excessive hepatic glycogen storage by activation of glycogenosis enzymes. Biological manifestations consist on elevated liver enzymes and hyperlactatemia. There is a link between administration of high dose of insulin and edema. Hepatic glycogenosis should be suspected when diabetes is uncontrolled and be considered as a differential diagnosis of steatosis. It may be associated and revealed by insulin edema directly related to excessive insulin intakes.
authors.affiliation: Service de médecine interne, DHU i2B, hôpital Saint-Antoine, université Paris 6, 184, rue du Faubourg-Saint-Antoine, 75012 Paris, France. Electronic address: thibault.mahevas@gmail.com.
authors.forename: T
authors.initials: T
authors.lastname: Mahévas
authors.affiliation: Service de médecine interne, DHU i2B, hôpital Saint-Antoine, université Paris 6, 184, rue du Faubourg-Saint-Antoine, 75012 Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Gobert
authors.affiliation: Service de médecine interne, DHU i2B, hôpital Saint-Antoine, université Paris 6, 184, rue du Faubourg-Saint-Antoine, 75012 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Gatfossé
authors.affiliation: Service de médecine interne, DHU i2B, hôpital Saint-Antoine, université Paris 6, 184, rue du Faubourg-Saint-Antoine, 75012 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Mekinian
authors.affiliation: Service de médecine interne, DHU i2B, hôpital Saint-Antoine, université Paris 6, 184, rue du Faubourg-Saint-Antoine, 75012 Paris, France.
authors.forename: O
authors.initials: O
authors.lastname: Fain
mesh_terms: D000293:Adolescent; D001706:Biopsy; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000473:pathology; D004487:Edema / Q000139:chemically induced*; D005260:Female; D006008:Glycogen Storage Disease / Q000175:diagnosis* / Q000209:etiology*; D006529:Hepatomegaly / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D006801:Humans; D007328:Insulin / Q000009:adverse effects*; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000175:diagnosis* / Q000209:etiology*; D013577:Syndrome
chemical_list: D007328:Insulin
keywords: Diabetes; Diabète; Glycogenosis; Glycogénose; Hepatomegaly; Hépatomégalie; Insulin edema; Insuline; Œdème