title: Impact of diabetes mellitus on acute outcomes of percutaneous coronary intervention in chronic total occlusions: insights from a US multicentre registry.
abstract: To examine the impact of diabetes mellitus on procedural outcomes of patients who underwent percutaneous coronary intervention for chronic total occlusion.
  
  
  
  We assessed the impact of diabetes mellitus on the outcomes of percutaneous coronary intervention for chronic total occlusion among 1308 people who underwent such procedures at 11 US centres between 2012 and 2015.
  
  
  
  The participants' mean ± sd age was 66 ± 10 years, 84% of the participants were men and 44.6% had diabetes. As compared with participants without diabetes, participants with diabetes were more likely to have undergone coronary artery bypass graft surgery (38 vs 31%; P = 0.006), and to have had previous heart failure (35 vs 22%; P = 0.0001) and peripheral arterial disease (19 vs 13%; P = 0.002). They also had a higher BMI (31 ± 6 kg/m2vs 29 ± 6 kg/m2; P = 0.001), similar Japanese chronic total occlusion scores (2.6 ± 1.2 vs 2.5 ± 1.2; P = 0.82) and similar final successful crossing technique: antegrade wire escalation (46 vs 47%; P = 0.66), retrograde (30 vs 28%; P = 0.66) and antegrade dissection re-entry (24 vs 25%; P = 0.66). Technical (91 vs 90%; P = 0.80) and procedural (89 vs 89%; P = 0.93) success was similar in the two groups, as was the incidence of major adverse cardiac events (2.2 vs 2.5%; P = 0.61).
  
  
  
  In a contemporary cohort of people undergoing percutaneous coronary intervention for chronic total occlusion, nearly one in two (45%) had diabetes mellitus. Procedural success and complication rates were similar in people with and without diabetes.
authors.affiliation: VA North Texas Healthcare System and UT Southwestern Medical Center, Dallas, TX, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Martinez-Parachini
authors.affiliation: VA North Texas Healthcare System and UT Southwestern Medical Center, Dallas, TX, USA.
authors.forename: A
authors.initials: A
authors.lastname: Karatasakis
authors.affiliation: Columbia University, New York, NY, USA.
authors.forename: D
authors.initials: D
authors.lastname: Karmpaliotis
authors.affiliation: Henry Ford Hospital, Detroit, MI, USA.
authors.forename: K
authors.initials: K
authors.lastname: Alaswad
authors.affiliation: Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: F A
authors.initials: FA
authors.lastname: Jaffer
authors.affiliation: Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
authors.forename: R W
authors.initials: RW
authors.lastname: Yeh
authors.affiliation: VA San Diego Healthcare System and University of California San Diego, San Diego, CA, USA.
authors.forename: M
authors.initials: M
authors.lastname: Patel
authors.affiliation: VA San Diego Healthcare System and University of California San Diego, San Diego, CA, USA.
authors.forename: J
authors.initials: J
authors.lastname: Bahadorani
authors.affiliation: Medical Center of the Rockies, Loveland, CO, USA.
authors.forename: A
authors.initials: A
authors.lastname: Doing
authors.affiliation: VA North Texas Healthcare System and UT Southwestern Medical Center, Dallas, TX, USA.
authors.forename: P-K
authors.initials: PK
authors.lastname: Nguyen-Trong
authors.affiliation: VA North Texas Healthcare System and UT Southwestern Medical Center, Dallas, TX, USA.
authors.forename: B A
authors.initials: BA
authors.lastname: Danek
authors.affiliation: VA North Texas Healthcare System and UT Southwestern Medical Center, Dallas, TX, USA.
authors.forename: J
authors.initials: J
authors.lastname: Karacsonyi
authors.affiliation: VA North Texas Healthcare System and UT Southwestern Medical Center, Dallas, TX, USA.
authors.forename: A
authors.initials: A
authors.lastname: Alame
authors.affiliation: VA North Texas Healthcare System and UT Southwestern Medical Center, Dallas, TX, USA.
authors.forename: B V
authors.initials: BV
authors.lastname: Rangan
authors.affiliation: Boston Scientific, Natick, MA, USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Thompson
authors.affiliation: VA North Texas Healthcare System and UT Southwestern Medical Center, Dallas, TX, USA.
authors.forename: S
authors.initials: S
authors.lastname: Banerjee
authors.affiliation: VA North Texas Healthcare System and UT Southwestern Medical Center, Dallas, TX, USA.|Minneapolis Heart Institute, Minneapolis, MN, USA.
authors.forename: E S
authors.initials: ES
authors.lastname: Brilakis
mesh_terms: D000368:Aged; D015992:Body Mass Index; D015897:Comorbidity; D001026:Coronary Artery Bypass / Q000706:statistics & numerical data; D054059:Coronary Occlusion / Q000453:epidemiology / Q000601:surgery*; D003920:Diabetes Mellitus / Q000453:epidemiology*; D005260:Female; D006333:Heart Failure / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D062645:Percutaneous Coronary Intervention / Q000379:methods*; D058729:Peripheral Arterial Disease / Q000453:epidemiology; D011379:Prognosis; D011446:Prospective Studies; D012042:Registries; D012189:Retrospective Studies; D016896:Treatment Outcome; D014481:United States