title: Peripheral Artery Disease and Aortic Disease.
abstract: We reviewed published MESA (Multi-Ethnic Study of Atherosclerosis) study articles concerning peripheral arterial disease, subclavian stenosis (SS), abdominal aortic calcium (AAC), and thoracic artery calcium (TAC). Important findings include, compared to non-Hispanic whites, lower ankle-brachial index (ABI) and more SS in African Americans, and higher ABI and less SS in Hispanic and Chinese Americans. Abnormal ABI and brachial pressure differences were associated with other subclinical cardiovascular disease (CVD) measures. Both very high and low ABI independently predicted increased CVD events. Looking at aortic measures, TAC and AAC were significantly associated with other subclinical CVD measures. Comparisons of AAC with coronary artery calcium (CAC) showed that both were less common in ethnic minority groups. However, although CAC was much more common in men than in women in multivariable analysis, this was not true of AAC. Also, when AAC and CAC were adjusted for each other in multivariable analysis, there was a stronger association for AAC than for CAC with CVD and total mortality.
authors.affiliation: Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, USA; Department of Medicine, University of California, San Diego, La Jolla, CA, USA. Electronic address: mcriqui@ucsd.edu.
authors.forename: Michael H
authors.initials: MH
authors.lastname: Criqui
authors.affiliation: Department of Cardiology, Dupuytren University Hospital, Limoges, France; Inserm 1094, Tropical Neuroepidemiology, University of Limoges, Limoges, France.
authors.forename: Victor
authors.initials: V
authors.lastname: Aboyans
authors.affiliation: Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, USA.
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Allison
authors.affiliation: Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, USA.
authors.forename: Julie O
authors.initials: JO
authors.lastname: Denenberg
authors.affiliation: Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, USA.
authors.forename: Nketi
authors.initials: N
authors.lastname: Forbang
authors.affiliation: Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: Mary M
authors.initials: MM
authors.lastname: McDermott
authors.affiliation: Department of Pathology and Laboratory Medicine, College of Medicine, University of Vermont, Colchester, VT, USA.
authors.forename: Christina L
authors.initials: CL
authors.lastname: Wassel
authors.affiliation: Heart Disease Prevention Program, Division of Cardiology, University of California, Irvine, Irvine, CA, USA.
authors.forename: Nathan D
authors.initials: ND
authors.lastname: Wong
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D055109:Ankle Brachial Index; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging; D001013:Aorta, Thoracic / Q000000981:diagnostic imaging; D001018:Aortic Diseases / Q000000981:diagnostic imaging / Q000208:ethnology*; D050197:Atherosclerosis / Q000000981:diagnostic imaging / Q000208:ethnology; D015415:Biomarkers / Q000378:metabolism; D059168:Carotid Intima-Media Thickness; D000072226:Computed Tomography Angiography; D005260:Female; D005819:Genetic Markers; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000000981:diagnostic imaging / Q000208:ethnology*; D015995:Prevalence; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D061205:Vascular Calcification / Q000208:ethnology*
chemical_list: D015415:Biomarkers; D005819:Genetic Markers