title: Early hyperoxemia may not increase mortality after cardiac arrest: a pilot study.
abstract: OBJECTIVE
  International Liaison Committee on Resuscitation guidelines advocate an arterial saturation of 94% to 96% after return of spontaneous circulation (ROSC). However, a few clinical trials have investigated the impact of postresuscitative O2therapy after cardiac arrest. We studied whether early hyperoxemia is associated with a poor post-ROSC outcome after in-hospital cardiac arrest.
  
  
  METHODS
  We retrospectively reviewed patients who experienced an in-hospital cardiac arrest from January 2005 to January 2011. Based on the results of the first arterial blood gas analysis (ABGA) within 10 minutes and a second ABGA from 60 to 120 minutes after ROSC, patients were classified into three groups: hyperoxemia (PaO2≥ 300 mmHg), normoxemia (300 mmHg > PaO2≥ 60 mmHg), and hypoxemia (PaO2< 60 mmHg or ratio of PaO2to fraction of inspired oxygen < 300). We examined whether early hyperoxemia was associated with survival and neurological outcome.
  
  
  RESULTS
  There were 792 patients who met the inclusion criteria: 638 (80.6%) in the hypoxemia group, 62 (7.8%) in the normoxemia group, and 92 (11.6%) in the hyperoxemia group. Multiple logistic regression analysis showed that hyperoxemia was not associated with survival (odds ratio [OR], 1.07; 95% confidence interval [CI], 0.30 to 3.84) or neurological outcome (OR, 1.03; 95% CI, 0.31 to 3.40).
  
  
  CONCLUSIONS
  Postresuscitation hyperoxemia was not associated with survival or neurological outcome in patients with ROSC after in-hospital cardiac arrest.
authors.affiliation: Department of Emergency Medicine, Hallym University Sacred Heart Hospital, Hallym University School of Medicine, Anyang, Korea.
authors.forename: Young Taeck
authors.initials: YT
authors.lastname: Oh
authors.affiliation: Department of Emergency Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
authors.forename: Yong Hwan
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Department of Emergency Medicine, Hallym University Sacred Heart Hospital, Hallym University School of Medicine, Anyang, Korea.
authors.forename: You Dong
authors.initials: YD
authors.lastname: Sohn
authors.affiliation: Department of Emergency Medicine, Hallym University Sacred Heart Hospital, Hallym University School of Medicine, Anyang, Korea.
authors.forename: Seung Min
authors.initials: SM
authors.lastname: Park
authors.affiliation: Department of Emergency Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Dong Hyuk
authors.initials: DH
authors.lastname: Shin
authors.affiliation: Department of Emergency Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
authors.forename: Seong Youn
authors.initials: SY
authors.lastname: Hwang
authors.affiliation: Department of Emergency Medicine, Pusan National University Hospital, Busan, Korea.
authors.forename: Suck Ju
authors.initials: SJ
authors.lastname: Cho
authors.affiliation: Department of Emergency Medicine, Konkuk University Medical Center, Seoul, Korea.
authors.forename: Sang O
authors.initials: SO
authors.lastname: Park
authors.affiliation: Department of Emergency Medicine, Bundang Jesaeng General Hospital, Seongnam, Korea.
authors.forename: Chong Kun
authors.initials: CK
authors.lastname: Hong
authors.affiliation: Department of Emergency Medicine, Hallym University Sacred Heart Hospital, Hallym University School of Medicine, Anyang, Korea.
authors.forename: Hee Cheol
authors.initials: HC
authors.lastname: Ahn
authors.affiliation: Department of Emergency Medicine, Hallym University Sacred Heart Hospital, Hallym University School of Medicine, Anyang, Korea.
authors.forename: Young Hwan
authors.initials: YH
authors.lastname: Lee
keywords: Cardiopulmonary resuscitation; Hyperoxemia; Mortality