title: Immunomodulatory Effects of Different Lactic Acid Bacteria on Allergic Response and Its Relationship with In Vitro Properties.
abstract: Some studies reported that probiotic could relieve allergy-induced damage to the host, but how to get a useful probiotic is still a challenge. In this study, the protective effects of three lactic acid bacteria (La, Lp and Lc) were evaluated in a mouse model, and its relationship with the in vitro properties was analyzed. The in vitro results indicated that La with the capacity to inhibit IL-4 production could have a better anti-allergy effect in vivo than two others. However, the animal trials showed that all LAB strains could alleviate allergen-induced airway inflammation. Among them, LAB strain Lp had a better effect in inhibiting allergic response through a modulation of Th1/Th2 balance and an increase of regulatory T cells. This difference could be explained by that different LAB strains have a strain-specific effect on gut microbiota closely associated with host immune responses. Finally, this study did not only obtain an effective anti-allergy probiotic strain via animal study, but also indicate that probiotic-induced effect on intestinal microbiota should be considered as an important screening index, apart from its inherent characteristics.
authors.affiliation: National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, P. R. China.|State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, P. R. China.
authors.forename: Chunqing
authors.initials: C
authors.lastname: Ai
authors.affiliation: National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, P. R. China.
authors.forename: Na
authors.initials: N
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, P. R. China.
authors.forename: Qiuxiang
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, P. R. China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, P. R. China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, P. R. China.
authors.forename: Fengwei
authors.initials: F
authors.lastname: Tian
authors.affiliation: Shaanxi University of Technology, School of Biological Science and Engineering, Hanzhong 723001, P. R. China.|Shanxi Radio & TV University, Xi'an 710119, P. R. China.
authors.forename: Pei
authors.initials: P
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
mesh_terms: D000485:Allergens / Q000009:adverse effects; D000818:Animals; D004195:Disease Models, Animal; D005516:Food Microbiology; D006967:Hypersensitivity / Q000178:diet therapy* / Q000276:immunology; D066298:In Vitro Techniques; D015847:Interleukin-4 / Q000378:metabolism*; D019344:Lactic Acid / Q000378:metabolism*; D007778:Lactobacillus / Q000276:immunology* / Q000302:isolation & purification / Q000378:metabolism; D051379:Mice; D019936:Probiotics / Q000008:administration & dosage* / Q000627:therapeutic use; D013154:Spleen / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000378:metabolism; D018417:Th1 Cells / Q000378:metabolism; D018418:Th2 Cells / Q000378:metabolism
chemical_list: D000485:Allergens; D015847:Interleukin-4; D019344:Lactic Acid