title: [Effect of compliance with an antibiotic prophylaxis protocol in surgical site infections in appendectomies. Prospective cohort study].
abstract: BACKGROUND
  Antibiotic prophylaxis is the most suitable tool for preventing surgical site infection. This study assessed compliance with antibiotic prophylaxis in surgery for acute appendicitis, and the effect of this compliance on surgical site infection.
  
  
  METHODS
  Prospective cohort study to evaluate compliance with antibiotic prophylaxis protocol in appendectomies. An assessment was made of the level of compliance with prophylaxis, as well as the causes of non-compliance. The incidence of surgical site infection was studied after a maximum incubation period of 30 days. The relative risk adjusted with a logistic regression model was used to assess the effect of non-compliance of prophylaxis on surgical site infection.
  
  
  RESULTS
  The study included a total of 930 patients. Antibiotic prophylaxis was indicated in all patients, and administered in 71.3% of cases, with an overall protocol compliance of 86.1%. The principal cause of non-compliance was time of initiation. Cumulative incidence of surgical site infection was 4.6%. No relationship was found between inadequate prophylaxis compliance and infection (relative risk=0.5; 95% CI: 0.1-1.9) (P>.05).
  
  
  CONCLUSIONS
  Compliance of antibiotic prophylaxis was high, but could be improved. No relationship was found between prophylaxis compliance and surgical site infection rate.
authors.affiliation: Departamento de Medicina Preventiva, Universidad Rey Juan Carlos, Alcorcón, Madrid, España.
authors.forename: Tomás
authors.initials: T
authors.lastname: Sánchez-Santana
authors.affiliation: Unidad de Medicina Preventiva, Hospital Universitario Fundación Alcorcón, Madrid, España.
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Del-Moral-Luque
authors.affiliation: Unidad de Cirugía General, Hospital Universitario Fundación Alcorcón, Madrid, España.
authors.forename: Pablo
authors.initials: P
authors.lastname: Gil-Yonte
authors.affiliation: Área de Diagnóstico por Imagen, Hospital Universitario Fundación Alcorcón, Madrid, España.
authors.forename: Luis
authors.initials: L
authors.lastname: Bañuelos-Andrío
authors.affiliation: Departamento de Medicina y Cirugía, Universidad Rey Juan Carlos, Alcorcón, Madrid, España.
authors.forename: Manuel
authors.initials: M
authors.lastname: Durán-Poveda
authors.affiliation: Departamento de Medicina Preventiva, Universidad Rey Juan Carlos, Alcorcón, Madrid, España; Unidad de Medicina Preventiva, Hospital Universitario Fundación Alcorcón, Madrid, España. Electronic address: grodriguez@fhalcorcon.es.
authors.forename: Gil
authors.initials: G
authors.lastname: Rodríguez-Caravaca
mesh_terms: D000328:Adult; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000008:administration & dosage / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis; D001062:Appendectomy; D004359:Drug Therapy, Combination; D004363:Drug Utilization; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use; D019983:Guideline Adherence; D006801:Humans; D010535:Laparoscopy; D016015:Logistic Models; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use; D011446:Prospective Studies; D012306:Risk; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D008795:Metronidazole; D019980:Amoxicillin-Potassium Clavulanate Combination
keywords: Antibiotic prophylaxis; Apendicectomía; Appendectomy; Cohort study; Estudio de cohortes; Incidence; Incidencia; Infección de herida quirúrgica; Profilaxis antibiótica; Surgical wound infection