title: Detecting cognitive decline.
abstract: There is growing consensus that dementia has a long gestation period; it is known that neurofibrillary tangles and amyloid plaques, the hallmarks of pathological change in dementia, are present in the brains of young adults. This study aimed to examine if decline in cognitive function can be detected earlier than previously thought. The researchers collected data from 10,308 participants aged 45-70 and tested them three times over ten years. They found that cognitive scores declined in all age that cognitive scores declined in all age categories (45-49, 50-54, 55-59, 60-64 and 65-70) with faster decline in older people.
authors.affiliation: The University of Portsmouth.
authors.forename: Ruth
authors.initials: R
authors.lastname: Sander