title: Risk of Cognitive Decline Associated With Paroxetine Use in Elderly Nursing Home Patients With Depression.
abstract: This study evaluated the risk of cognitive decline associated with paroxetine use in elderly nursing home patients with depression.
  
  
  
  A retrospective cohort study was conducted using the 2007 to 2010 Medicare Part D claims and minimum data set (MDS) data involving new users of paroxetine and other selective serotonin reuptake inhibitors (SSRIs). The primary outcome was MDS Cognition Scale. The repeated-measures mixed model was used to examine the effect of paroxetine on cognition after controlling for other factors.
  
  
  
  The baseline MDS Cognition Scale measures for paroxetine (n = 63) and other SSRI users (n =1018) were 2.02 (±1.85) and 2.50 (±2.39), respectively. The repeated-measures mixed model did not find statistically significant difference in cognition with the use of paroxetine (β = 0.02, 95% CI: -0.16 to 0.21]) when compared to other SSRIs.
  
  
  
  There was no differential effect of paroxetine on cognition when compared to other SSRIs.
authors.affiliation: Department of Pharmaceutical Health Outcomes and Policy, Texas Medical Center, College of Pharmacy, University of Houston, Houston, TX, USA.
authors.forename: Vishal
authors.initials: V
authors.lastname: Bali
authors.affiliation: Department of Pharmaceutical Health Outcomes and Policy, Texas Medical Center, College of Pharmacy, University of Houston, Houston, TX, USA.
authors.forename: Satabdi
authors.initials: S
authors.lastname: Chatterjee
authors.affiliation: Department of Pharmaceutical Health Outcomes and Policy, Texas Medical Center, College of Pharmacy, University of Houston, Houston, TX, USA.
authors.forename: Michael L
authors.initials: ML
authors.lastname: Johnson
authors.affiliation: Department of Pharmaceutical Health Outcomes and Policy, Texas Medical Center, College of Pharmacy, University of Houston, Houston, TX, USA.
authors.forename: Hua
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA.
authors.forename: Ryan M
authors.initials: RM
authors.lastname: Carnahan
authors.affiliation: Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA rraparasu@uh.edu.
authors.forename: Rajender R
authors.initials: RR
authors.lastname: Aparasu
mesh_terms: D000368:Aged; D060825:Cognitive Dysfunction / Q000139:chemically induced*; D003863:Depression / Q000188:drug therapy*; D005260:Female; D006707:Homes for the Aged; D006801:Humans; D008297:Male; D009735:Nursing Homes; D017374:Paroxetine / Q000009:adverse effects*; D012306:Risk; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*
chemical_list: D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors
keywords: cognition; depression; elderly; paroxetine