title: Role of low-grade inflammation in osteoarthritis.
abstract: Inflammatory changes in joint tissues can be detected by modern imaging techniques in osteoarthritis patients, but may be clinically subtle compared with many other types of arthritis. These changes associate with disease progression and clinical severity, and many inflammatory mediators may have biomarker utility. Moreover, a number of inflammatory mechanisms play a role in animal models of disease, but it is still not clear which mechanisms predominate and might be therapeutically manipulated most effectively. This review highlights specific examples of recent advances published in the past 18 months that have advanced this field.
  
  
  
  Clinical investigators now show that synovial inflammation is associated with pain sensitization, and similar to knee osteoarthritis, is a common and important feature of hand osteoarthritis. In addition, recent advances in basic studies demonstrate inflammatory markers and mechanisms related to leukocyte activity, innate immune mechanisms, and the chondrocyte-intrinsic inflammatory response that might provide better opportunities for early detection, prognosis, or therapeutic intervention.
  
  
  
  Inflammation plays a central role in osteoarthritis pathogenesis, but additional translational work in this field is necessary, as are more clinical trials of anti-inflammatory approaches.
authors.affiliation: aSection of Rheumatology and Translational Musculoskeletal Research Center, Corporal Michael J. Crescenz Department of Veterans Affairs Medical Center bDivision of Rheumatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia Pennsylvania, USA.
authors.forename: Carla R
authors.initials: CR
authors.lastname: Scanzello
mesh_terms: D000818:Animals; D018450:Disease Progression; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D007962:Leukocytes / Q000473:pathology; D009765:Obesity / Q000150:complications; D010003:Osteoarthritis / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D010146:Pain / Q000209:etiology; D013585:Synovitis / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology