title: Tissue-resident macrophages - how to humanize our knowledge.
abstract: Tissue macrophages of fetal and adult origin have pivotal roles in tissue homeostasis and organ inflammation. Recently several functional and transcriptomic studies have revealed their unique module-like transcriptomic organization leading to enormous tissue-dependent functional plasticity. In this review, we discuss the development, tissue adaption and function of resident murine and human macrophages. Finally, we discuss our limited knowledge on human tissue macrophages and provide our opinion on their relevance during disease and for clinical application. At last we discuss a path towards a better understanding of human tissue macrophage populations using state of the art transcriptomic and epigenetic techniques to enable understanding of these powerful tissue-resident phagocytes.
authors.affiliation: Department of Genomics and Immunoregulation, Life and Medical Science Institute, University of Bonn, Bonn, Germany.|Single Cell Genomics and Epigenomics Unit, German Center for Neurodegenerative Diseases, University of Bonn, Bonn, Germany.|Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
authors.forename: Andreas
authors.initials: A
authors.lastname: Schlitzer
authors.affiliation: Department of Genomics and Immunoregulation, Life and Medical Science Institute, University of Bonn, Bonn, Germany.|Single Cell Genomics and Epigenomics Unit, German Center for Neurodegenerative Diseases, University of Bonn, Bonn, Germany.
authors.forename: Joachim L
authors.initials: JL
authors.lastname: Schultze
mesh_terms: D000818:Animals; D006706:Homeostasis; D006801:Humans; D007249:Inflammation / Q000473:pathology; D008262:Macrophage Activation; D008264:Macrophages / Q000378:metabolism*; D009928:Organ Specificity; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D014157:Transcription Factors