title: Psychiatric disorders prior to amyotrophic lateral sclerosis.
abstract: It is recognized that neuropsychiatric conditions are overrepresented in amyotrophic lateral sclerosis (ALS) patient kindreds and psychiatric symptoms may precede the onset of motor symptoms. Using a hospital record linkage database, hospitalization with a diagnosis of schizophrenia, bipolar disorder, depression, or anxiety was significantly associated with a first diagnosis of ALS within the following year. This is likely to specifically reflect the clinicopathological overlap of ALS with frontotemporal dementia. A diagnosis of depression was significantly associated with a first record of ALS ≥5 years later, in keeping with growing evidence for major depressive disorder as an early marker of cerebral neurodegeneration. Ann Neurol 2016;80:935-938.
authors.affiliation: Oxford University Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital.
authors.forename: Martin R
authors.initials: MR
authors.lastname: Turner
authors.affiliation: Oxford University Nuffield Department of Population Health, Old Road Campus, Oxford, United Kingdom.
authors.forename: Raph
authors.initials: R
authors.lastname: Goldacre
authors.affiliation: Oxford University Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital.
authors.forename: Kevin
authors.initials: K
authors.lastname: Talbot
authors.affiliation: Oxford University Nuffield Department of Population Health, Old Road Campus, Oxford, United Kingdom.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Goldacre
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000453:epidemiology*; D016022:Case-Control Studies; D015897:Comorbidity; D016208:Databases, Factual; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology*; D013997:Time Factors