title: Piperacillin-Tazobactam-induced Adverse Drug Events in Pediatric Patients on Outpatient Parenteral Antimicrobial Therapy.
abstract: We report a significantly higher occurrence of adverse events associated with prolonged courses of piperacillin-tazobactam compared with other antibacterial agents used for pediatric outpatient parenteral antimicrobial therapy. These adverse events were characterized by a constellation of clinical findings including fever, hematologic abnormalities and transaminitis. Adverse events related to piperacillin-tazobactam should be considered in patients who develop a febrile illness associated with a prolonged course of therapy.
authors.affiliation: *Department of Pediatrics, Jordan University of Science and Technology, Irbid, Jordan; †Center for Pediatric Infectious Diseases, Cleveland Clinic Children's, Cleveland, Ohio; and ‡Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Dawood
authors.initials: D
authors.lastname: Yusef
authors.forename: Blanca E
authors.initials: BE
authors.lastname: Gonzalez
authors.forename: Charles B
authors.initials: CB
authors.lastname: Foster
authors.forename: Johanna
authors.initials: J
authors.lastname: Goldfarb
authors.forename: Carla
authors.initials: C
authors.lastname: Saracusa
authors.forename: Sarah
authors.initials: S
authors.lastname: Worley
authors.forename: Camille
authors.initials: C
authors.lastname: Sabella
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007263:Infusions, Parenteral / Q000706:statistics & numerical data*; D053208:Kaplan-Meier Estimate; D008297:Male; D010045:Outpatients / Q000706:statistics & numerical data; D010397:Penicillanic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010878:Piperacillin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D000077725:Piperacillin, Tazobactam Drug Combination
chemical_list: D000900:Anti-Bacterial Agents; D000077725:Piperacillin, Tazobactam Drug Combination; D010397:Penicillanic Acid; D010878:Piperacillin