title: The Last Ten Years of Advancements in Plant-Derived Recombinant Vaccines against Hepatitis B.
abstract: Disease prevention through vaccination is considered to be the greatest contribution to public health over the past century. Every year more than 100 million children are vaccinated with the standard World Health Organization (WHO)-recommended vaccines including hepatitis B (HepB). HepB is the most serious type of liver infection caused by the hepatitis B virus (HBV), however, it can be prevented by currently available recombinant vaccine, which has an excellent record of safety and effectiveness. To date, recombinant vaccines are produced in many systems of bacteria, yeast, insect, and mammalian and plant cells. Among these platforms, the use of plant cells has received considerable attention in terms of intrinsic safety, scalability, and appropriate modification of target proteins. Research groups worldwide have attempted to develop more efficacious plant-derived vaccines for over 30 diseases, most frequently HepB and influenza. More inspiring, approximately 12 plant-made antigens have already been tested in clinical trials, with successful outcomes. In this study, the latest information from the last 10 years on plant-derived antigens, especially hepatitis B surface antigen, approaches are reviewed and breakthroughs regarding the weak points are also discussed.
authors.affiliation: School of Biological Sciences & Technology, Chonnam National University, Gwangju 61186, Korea. yhjoung@chonnam.ac.kr.
authors.forename: Young Hee
authors.initials: YH
authors.lastname: Joung
authors.affiliation: School of Biological Sciences & Technology, Chonnam National University, Gwangju 61186, Korea. shpark860@daum.net.
authors.forename: Se Hee
authors.initials: SH
authors.lastname: Park
authors.affiliation: Molecular Biofarming Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), Daejeon 34141, Korea. irony83@kribb.re.kr.
authors.forename: Ki-Beom
authors.initials: KB
authors.lastname: Moon
authors.affiliation: Molecular Biofarming Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), Daejeon 34141, Korea. jeonjh@kribb.re.kr.
authors.forename: Jae-Heung
authors.initials: JH
authors.lastname: Jeon
authors.affiliation: Molecular Biofarming Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), Daejeon 34141, Korea. hscho@kribb.re.kr.
authors.forename: Hye-Sun
authors.initials: HS
authors.lastname: Cho
authors.affiliation: Molecular Biofarming Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), Daejeon 34141, Korea. hyuns@kribb.re.kr.
authors.forename: Hyun-Soon
authors.initials: HS
authors.lastname: Kim
mesh_terms: D000818:Animals; D001709:Biotechnology / Q000379:methods; D015870:Gene Expression; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control*; D006514:Hepatitis B Surface Antigens / Q000235:genetics / Q000276:immunology*; D017325:Hepatitis B Vaccines / Q000235:genetics / Q000276:immunology* / Q000627:therapeutic use*; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology*; D006801:Humans; D030821:Plants, Genetically Modified / Q000235:genetics*; D022462:Vaccines, Edible / Q000235:genetics / Q000276:immunology / Q000627:therapeutic use; D014614:Vaccines, Synthetic / Q000235:genetics / Q000276:immunology / Q000627:therapeutic use
chemical_list: D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D022462:Vaccines, Edible; D014614:Vaccines, Synthetic
keywords: antigen; hepatitis B virus; molecular farming; plant edible vaccine; recombinant protein; virus-like particles