title: HIF stabilization by prolyl hydroxylase inhibitors for the treatment of anemia in chronic kidney disease.
abstract: The treatment of anemia with erythropoiesis-stimulating agents and iron supplementation has become the standard of care in patients with chronic kidney disease. Because of the risks associated with this approach, hypoxia inducible factor stabilizing prolyl hydroxylase inhibitors were developed as a potential treatment alternative. In recent phase 2 trials, these agents raised hemoglobin in a predictable and controlled manner and improved markers of iron metabolism. More experience is needed to establish long-term efficacy, tolerability, and safety, and to determine whether their use is associated with lower iron requirements.
authors.affiliation: Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address: christina.wyatt@mssm.edu.
authors.forename: Christina M
authors.initials: CM
authors.lastname: Wyatt
authors.affiliation: Institut National de la Santé et de la Recherche Médicale U-1018, Team 5, Hôpital Paul Brousse, Paris-Sud University and Versailles Saint-Quentin-en-Yvelines University (Paris-Ile-de-France-Ouest University), Villejuif, France.
authors.forename: Tilman B
authors.initials: TB
authors.lastname: Drüeke
mesh_terms: D000740:Anemia / Q000188:drug therapy* / Q000209:etiology; D006397:Hematinics / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D064799:Hypoxia-Inducible Factor-Proline Dioxygenases / Q000037:antagonists & inhibitors*; D051436:Renal Insufficiency, Chronic / Q000150:complications*
chemical_list: D006397:Hematinics; D064799:Hypoxia-Inducible Factor-Proline Dioxygenases