title: Severe Disseminated Mycobacterium avium Infection in a Patient with a Positive Serum Autoantibody to Interferon-γ.
abstract: We herein report a case of disseminated Mycobacterium avium infection that involved both optic nerves, the conjunctiva, the right lower lung, and multiple skin lesions, including a thoracic nodule. The patient was a 65-year-old man without any significant medical history. The pathogen was detected in the patient's eye discharge, sputum, bronchial lavage fluid, and thoracic nodule. Anti-mycobacterial chemotherapy, including clarithromycin, rifampicin, and ethambutol, was administered, and the thoracic nodule was resected. An autoantibody to interferon-γ was detected in the patient's serum. Bilateral swelling of his optic nerves and facial dermatitis improved after initiating anti-mycobacterial chemotherapy.
authors.affiliation: Department of Internal Medicine, Ohta-Nishinouchi Hospital, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ikeda
authors.forename: Kiwamu
authors.initials: K
authors.lastname: Nakamura
authors.forename: Mei
authors.initials: M
authors.lastname: Ikenori
authors.forename: Takahiro
authors.initials: T
authors.lastname: Saito
authors.forename: Keisuke
authors.initials: K
authors.lastname: Nagamine
authors.forename: Minoru
authors.initials: M
authors.lastname: Inoue
authors.forename: Takuro
authors.initials: T
authors.lastname: Sakagami
authors.forename: Hiroko
authors.initials: H
authors.lastname: Suzuki
authors.forename: Mariko
authors.initials: M
authors.lastname: Usui
authors.forename: Keiji
authors.initials: K
authors.lastname: Kanemitsu
authors.forename: Akinori
authors.initials: A
authors.lastname: Matsumoto
authors.forename: Takuro
authors.initials: T
authors.lastname: Shinbo
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood*; D017291:Clarithromycin / Q000627:therapeutic use; D004977:Ethambutol / Q000627:therapeutic use; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology*; D008297:Male; D015270:Mycobacterium avium-intracellulare Infection / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D012293:Rifampin / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D001323:Autoantibodies; D007371:Interferon-gamma; D004977:Ethambutol; D017291:Clarithromycin; D012293:Rifampin