title: Cell-ECM Interactions in Tumor Invasion.
abstract: The cancer cells obtain their invasion potential not only by genetic mutations, but also by changing their cellular biophysical and biomechanical features and adapting to the surrounding microenvironments. The extracellular matrix, as a crucial component of the tumor microenvironment, provides the mechanical support for the tissue, mediates the cell-microenvironment interactions, and plays a key role in cancer cell invasion. The biomechanics of the extracellular matrix, particularly collagen, have been extensively studied in the biomechanics community. Cell migration has also enjoyed much attention from both the experimental and modeling efforts. However, the detailed mechanistic understanding of tumor cell-ECM interactions, especially during cancer invasion, has been unclear. This chapter reviews the recent advances in the studies of ECM biomechanics, cell migration, and cell-ECM interactions in the context of cancer invasion.
authors.affiliation: Department of Mathematics and Statistics, Georgia State University, Atlanta, GA, 30303, USA.
authors.forename: Xiuxiu
authors.initials: X
authors.lastname: He
authors.affiliation: Department of Mathematics and Statistics, Georgia State University, Atlanta, GA, 30303, USA.
authors.forename: Byoungkoo
authors.initials: B
authors.lastname: Lee
authors.affiliation: Department of Mathematics and Statistics, Georgia State University, Atlanta, GA, 30303, USA. yjiang12@gsu.edu.
authors.forename: Yi
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D002448:Cell Adhesion; D002450:Cell Communication; D002465:Cell Movement; D003094:Collagen / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D022001:Focal Adhesions / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D040542:Mechanotransduction, Cellular; D051379:Mice; D015233:Models, Statistical; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D009360:Neoplastic Cells, Circulating / Q000378:metabolism* / Q000473:pathology; D059016:Tumor Microenvironment
chemical_list: D003094:Collagen
keywords: Cancer invasion; Cell migration; Cell-ECM interactions; Collagen; Extracellular matrix; Mathematical models; Mechanotransduction