title: Anti-Adipogenic Effects of Ethanol Extracts Prepared from Selected Medicinal Herbs in 3T3-L1 Cells.
abstract: Obesity is a major risk factor for various metabolic diseases such as cardiovascular disease, hypertension, and type 2 diabetes mellitus. In this study, we prepared ethanol extracts fromAgastache rugosa(ARE),Chrysanthemum zawadskii(CZE),Mentha arvensis(MAE),Perilla frutescens(PFE),Leonurus sibiricus(LSE),Gardenia jasminoides(GJE), andLycopus coreanus(LCE). The anti-oxidant and anti-adipogenic effects were evaluated. The IC50values for ascorbic acid and LCE against 2,2-diphenyl-1-picrylhydrazyl radicals were 246.2 μg/mL and 166.2 μg/mL, respectively, followed by ARE (186.6 μg/mL), CZE (198.6 μg/mL), MAE (337.1 μg/mL), PFE (415.3 μg/mL), LSE (548.2 μg/mL), and GJE (626.3 μg/mL). In non-toxic concentration ranges, CZE had a strong inhibitory effect against 3T3-L1 adipogenes (84.5%) than those of the other extracts. Furthermore, the anti-adipogenic effect of CZE is largely limited in the early stage of adipogenesis, and we revealed that the inhibitory role of CZE in adipogenesis is required for the activation of Wnt signaling. Our results provide scientific evidence that the anti-adipogenic effect of CZE can be applied as an ingredient for the development of functional foods and nutri-cosmetics for obesity prevention.
authors.affiliation: Department of Food, Nutrition and Biotechnology, Kyungnam University, Gyeongnam 51767, Korea.
authors.forename: Min-Jun
authors.initials: MJ
authors.lastname: Park
authors.affiliation: Traditional and Biomedical Research Center, Daejeon 34520, Korea.
authors.forename: Ji-Hye
authors.initials: JH
authors.lastname: Song
authors.affiliation: Department of Food, Nutrition and Biotechnology, Kyungnam University, Gyeongnam 51767, Korea.
authors.forename: Myung-Soo
authors.initials: MS
authors.lastname: Shon
authors.affiliation: Department of Nursing, Kyungnam University, Gyeongnam 51767, Korea.
authors.forename: Hae Ok
authors.initials: HO
authors.lastname: Kim
authors.affiliation: Gyeongbuk Regional Industry Evaluation, Daegyeong Institute for Regional Program Evaluation, Daegu 38542, Korea.
authors.forename: O Jun
authors.initials: OJ
authors.lastname: Kwon
authors.affiliation: Department of Herbology, Daegu Haany University, Daegu 42158, Korea.
authors.forename: Seong-Soo
authors.initials: SS
authors.lastname: Roh
authors.affiliation: Department of Food and Nutrition, Yeungnam University, Gyeongbuk 38541, Korea.
authors.forename: Choon Young
authors.initials: CY
authors.lastname: Kim
authors.affiliation: Department of Food, Nutrition and Biotechnology, Kyungnam University, Gyeongnam 51767, Korea.
authors.forename: Gyo-Nam
authors.initials: GN
authors.lastname: Kim
keywords: Chrysanthemum zawadskii; Wnt signaling; adipognesis; medicinal herb; obesity