title: Oxidative Stress Status in Childhood Obesity: A Potential Risk Predictor.
abstract: BACKGROUND Childhood obesity characterized by excessive fat in the body is one of the most serious health problems worldwide due to the social, medical, and physiological complications. Obesity and associated diseases are triggering factors for oxidative stress and inflammation. The aim of this study was to explore the possible association between childhood obesity and inflammatory and oxidative status. MATERIAL AND METHODS Thirty-seven obese children and 37 healthy controls selected from among children admitted to BLIND University Paediatrics Department were included in the study. Anthropometric measurements were performed using standard methods. Glucose, lipid parameters, CRP, insulin, total oxidant status (TOS), total anti-oxidant status (TAS) levels, and total thiol levels (TTL) were measured in serum. HOMA index (HOMA-IR) were calculated. The differences between the groups were evaluated statistically using the Mann-Whitney U test. RESULTS Body mass index was significantly higher in the obese group (median: 28.31(p<0.001). Glucose metabolism, insulin, and HOMA-IR levels were significantly higher in the obese group (both p<0.001). Total cholesterol, HDL cholesterol, LDL cholesterol, and triglyceride levels were significantly higher in the obese group (p<0.001). TAS (med: 2.5 µmol Trolox eq/L (1.7-3.3)) and TOS (med: 49.1 µmol H2O2 eq/L (34.5-78.8)) levels and TTL (med: 0.22 mmol/L (0.16-0.26)) were significantly higher in the obese group (p=0.001). CRP levels showed positive correlation with TOS and negative correlation with TTL levels (p=0.005, r=0.473; p=0.01, r=-0.417; respectively). TTL levels exhibited negative correlation with TOS levels (p=0.03, r=-0.347). CONCLUSIONS In conclusion, obese children were exposed to more oxidative burden than children with normal weight. Increased systemic oxidative stress induced by childhood obesity can cause development of obesity-related complications and diseases. Widely focussed studies are required on the use of oxidative parameters as early prognostic parameters in detection of obesity-related complications.
authors.affiliation: Department of Biochemistry, Bezmialem Vakif University, Medical Faculty, Istanbul, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Kilic
authors.affiliation: Department of Biochemistry, Bezmialem Vakif University, Medical Faculty, Istanbul, Turkey.
authors.forename: Ömer Faruk
authors.initials: ÖF
authors.lastname: Özer
authors.affiliation: Department of Biochemistry, Medeniyet University, Medical Faculty, Istanbul, Turkey.
authors.forename: Aybala
authors.initials: A
authors.lastname: Erek Toprak
authors.affiliation: Department of Biochemistry, Medeniyet University, Medical Faculty, Istanbul, Turkey.
authors.forename: Hayriye
authors.initials: H
authors.lastname: Erman
authors.affiliation: Department of Paediatrics, Bezmialem Vakif University, Medical Faculty, Istanbul, Turkey.
authors.forename: Emel
authors.initials: E
authors.lastname: Torun
authors.affiliation: Department of Biochemistry, Bezmialem Vakif University, Medical Faculty, Istanbul, Turkey.
authors.forename: Sıddıka
authors.initials: S
authors.lastname: Kesgin Ayhan
authors.affiliation: Department of Biochemistry, Bezmialem Vakif University, Medical Faculty, Istanbul, Turkey.
authors.forename: Hifa Gülru
authors.initials: HG
authors.lastname: Caglar
authors.affiliation: Department of Biochemistry, Bezmialem Vakif University, Medical Faculty, Istanbul, Turkey.
authors.forename: Sahbettin
authors.initials: S
authors.lastname: Selek
authors.affiliation: Department of Biochemistry, Bezmialem Vakif University, Medical Faculty, Istanbul, Turkey.
authors.forename: Abdurrahim
authors.initials: A
authors.lastname: Kocyigit
mesh_terms: D000293:Adolescent; D000975:Antioxidants / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D002648:Child; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood; D018384:Oxidative Stress / Q000502:physiology*; D063766:Pediatric Obesity / Q000097:blood*; D012307:Risk Factors
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D008076:Cholesterol, HDL; D007328:Insulin; D002097:C-Reactive Protein; D002784:Cholesterol