title: Role of non-coding RNA transcription around gene regulatory elements in transcription factor recruitment.
abstract: Eukaryotic cells produce a variety of non-coding RNAs (ncRNAs), many of which have been shown to play pivotal roles in biological processes such as differentiation, maintenance of pluripotency of stem cells, and cellular response to various stresses. Genome-wide analyses have revealed that many ncRNAs are transcribed around regulatory DNA elements located proximal or distal to gene promoters, but their biological functions are largely unknown. Recently, it has been demonstrated in yeast and mouse that ncRNA transcription around gene promoters and enhancers facilitates DNA binding of transcription factors to their target sites. These results suggest universal roles of promoter/enhancer-associated ncRNAs in the recruitment of transcription factors to their binding sites.
authors.affiliation: a Department of Life Sciences , The University of Tokyo , Japan.
authors.forename: Naomichi
authors.initials: N
authors.lastname: Takemata
authors.affiliation: a Department of Life Sciences , The University of Tokyo , Japan.|b Department of Biological Sciences , The University of Tokyo , Japan.
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Ohta
mesh_terms: D000818:Animals; D004742:Enhancer Elements, Genetic; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D022661:RNA, Untranslated / Q000235:genetics*; D012045:Regulatory Sequences, Nucleic Acid; D012568:Schizosaccharomyces / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D022661:RNA, Untranslated; D014157:Transcription Factors
keywords: Corepressor; enhancer; gene expression; ncRNA; promoter; transcription factor