title: Proper balance of omega-3 and omega-6 fatty acid supplements with topical cyclosporine attenuated contact lens-related dry eye syndrome.
abstract: Essential fatty acids had been applied in the treatment of dry eye syndrome (DES), but the effects of different combinations of fatty acids have not been investigated. 360 long-term contact lens wearers were included in this double-blinded study. Omega-3 and omega-6 fatty acids were combined in different ratios and supplied to the participants that were randomly divided into six groups, and the effects of different essential fatty acids mixture on DES with or without topical cyclosporine were investigated. More than half of long-term contact lens wearers suffered from DES, which were found to be attenuated by oral supplement of properly balanced O3FA and O6FA fatty acid. The topical cyclosporine treatment considerably inhibited the production of cytokines compared to the cyclosporine negative groups, which further relieved DES. Proper balance of omega-3 and omega-6 fatty acid combination significantly alleviated contact lens-related DES.
authors.affiliation: The Affiliated Hospital of Medical College, Ningbo University, 247 Renmin Rd, Jiangbei District, Ningbo, 315020, Zhejiang, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
authors.affiliation: The Affiliated Hospital of Medical College, Ningbo University, 247 Renmin Rd, Jiangbei District, Ningbo, 315020, Zhejiang, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.affiliation: The Affiliated Hospital of Medical College, Ningbo University, 247 Renmin Rd, Jiangbei District, Ningbo, 315020, Zhejiang, China.
authors.forename: Jingfang
authors.initials: J
authors.lastname: Hao
authors.affiliation: The Affiliated Hospital of Medical College, Ningbo University, 247 Renmin Rd, Jiangbei District, Ningbo, 315020, Zhejiang, China. luyang2323@163.com.
authors.forename: Lu
authors.initials: L
authors.lastname: Yang
mesh_terms: D060433:Administration, Ophthalmic; D000284:Administration, Oral; D000328:Adult; D003261:Contact Lenses / Q000009:adverse effects*; D016572:Cyclosporine / Q000008:administration & dosage / Q000627:therapeutic use*; D016207:Cytokines / Q000032:analysis / Q000096:biosynthesis; D019587:Dietary Supplements; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D015352:Dry Eye Syndromes / Q000188:drug therapy*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000627:therapeutic use*; D043371:Fatty Acids, Omega-6 / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D009883:Ophthalmic Solutions; D013666:Tears / Q000737:chemistry
chemical_list: D016207:Cytokines; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D009883:Ophthalmic Solutions; D016572:Cyclosporine
keywords: Dry eye syndrome; Fatty acids; Lens; Omega-3; Omega-6