title: Using Innovative Acoustic Analysis to Predict the Postoperative Outcomes of Unilateral Vocal Fold Paralysis.
abstract: Objective.Autologous fat injection laryngoplasty is ineffective for some patients with iatrogenic vocal fold paralysis, and additional laryngeal framework surgery is often required. An acoustically measurable outcome predictor for lipoinjection laryngoplasty would assist phonosurgeons in formulating treatment strategies.Methods.Seventeen thyroid surgery patients with unilateral vocal fold paralysis participated in this study. All subjects underwent lipoinjection laryngoplasty to treat postsurgery vocal hoarseness. After treatment, patients were assigned to success and failure groups on the basis of voice improvement. Linear prediction analysis was used to construct a new voice quality indicator, the number of irregular peaks (NIrrP). It compared with the measures used in the Multi-Dimensional Voice Program (MDVP), such as jitter (frequency perturbation) and shimmer (perturbation of amplitude).Results.By comparing the [i] vowel produced by patients before the lipoinjection laryngoplasty (AUC = 0.98, 95% CI = 0.78-0.99), NIrrP was shown to be a more accurate predictor of long-term surgical outcomes than jitter (AUC = 0.73, 95% CI = 0.47-0.91) and shimmer (AUC = 0.63, 95% CI = 0.37-0.85), as identified by the receiver operating characteristic curve.Conclusions.NIrrP measured using the LP model could be a more accurate outcome predictor than the parameters used in the MDVP.
authors.affiliation: Department of Otolaryngology, China Medical University Hospital, Taichung, Taiwan; Department of Audiology and Speech-Language Pathology, Asia University, Taichung, Taiwan.
authors.forename: Yung-An
authors.initials: YA
authors.lastname: Tsou
authors.affiliation: Department of Electrical Engineering, National Tsing Hua University, Hsinchu, Taiwan.
authors.forename: Yi-Wen
authors.identifier: 0000-0002-4090-5483
authors.initials: YW
authors.lastname: Liu
authors.affiliation: Department of Sports Medicine, China Medical University, Taichung, Taiwan.
authors.forename: Wen-Dien
authors.identifier: 0000-0001-5546-5874
authors.initials: WD
authors.lastname: Chang
authors.affiliation: Department of Electrical Engineering, National Tsing Hua University, Hsinchu, Taiwan.
authors.forename: Wei-Chen
authors.initials: WC
authors.lastname: Chen
authors.affiliation: Department of Electrical Engineering, National Tsing Hua University, Hsinchu, Taiwan.
authors.forename: Hsiang-Chun
authors.initials: HC
authors.lastname: Ke
authors.affiliation: Department of Biological Science and Technology, National Chiao-Tung University, Hsinchu, Taiwan.
authors.forename: Wen-Yang
authors.initials: WY
authors.lastname: Lin
authors.affiliation: Department of Sports Medicine, China Medical University, Taichung, Taiwan.
authors.forename: Hsing-Rong
authors.initials: HR
authors.lastname: Yang
authors.affiliation: Department of Otolaryngology, China Medical University Hospital, Taichung, Taiwan.
authors.forename: Dung-Yun
authors.initials: DY
authors.lastname: Shie
authors.affiliation: Department of Otolaryngology, China Medical University Hospital, Taichung, Taiwan.
authors.forename: Ming-Hsui
authors.initials: MH
authors.lastname: Tsai
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D058753:Laryngoplasty / Q000379:methods* / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D012815:Signal Processing, Computer-Assisted; D013018:Sound Spectrography; D014826:Vocal Cord Paralysis / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery*; D014827:Vocal Cords / Q000502:physiology / Q000503:physiopathology