title: Recursive Model Identification for the Evaluation of Baroreflex Sensitivity.
abstract: A method for the recursive identification of physiological models of the cardiovascular baroreflex is proposed and applied to the time-varying analysis of vagal and sympathetic activities. The proposed method was evaluated with data from five newborn lambs, which were acquired during injection of vasodilator and vasoconstrictors and the results show a close match between experimental and simulated signals. The model-based estimation of vagal and sympathetic contributions were consistent with physiological knowledge and the obtained estimators of vagal and sympathetic activities were compared to traditional markers associated with baroreflex sensitivity. High correlations were observed between traditional markers and model-based indices.
authors.affiliation: INSERM, U1099, Rennes, 35000, France. virginie.lerolle@univ-rennes1.fr.|Université de Rennes 1, LTSI, Rennes, 35000, France. virginie.lerolle@univ-rennes1.fr.
authors.forename: Virginie
authors.initials: V
authors.lastname: Le Rolle
authors.affiliation: INSERM, U1099, Rennes, 35000, France.|Université de Rennes 1, LTSI, Rennes, 35000, France.|CHU Rennes, Pole de pédiatrie médico-chirurgicale et génétique clinique - Service de pédiatrie, Rennes, 35000, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Beuchée
authors.affiliation: Department of Pediatrics, University of Sherbrooke, Sherbrooke, QC, J1H5N4, Canada.
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Praud
authors.affiliation: Department of Pediatrics, University of Sherbrooke, Sherbrooke, QC, J1H5N4, Canada.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Samson
authors.affiliation: INSERM, U1099, Rennes, 35000, France.|Université de Rennes 1, LTSI, Rennes, 35000, France.|CHU Rennes, Pole de pédiatrie médico-chirurgicale et génétique clinique - Service de pédiatrie, Rennes, 35000, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Pladys
authors.affiliation: INSERM, U1099, Rennes, 35000, France.|Université de Rennes 1, LTSI, Rennes, 35000, France.
authors.forename: Alfredo I
authors.initials: AI
authors.lastname: Hernández
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D017704:Baroreflex / Q000502:physiology*; D002319:Cardiovascular System; D003198:Computer Simulation; D006339:Heart Rate; D012756:Sheep; D013564:Sympathetic Nervous System / Q000502:physiology*; D014630:Vagus Nerve / Q000502:physiology*
keywords: Baroreflex; Lamb; Newborn; Parameters identification; Physiological model