title: Diverted recycling-Shigella subversion of Rabs.
abstract: Small GTPases of the Rab protein family control intracellular vesicular trafficking to allow their communication and maintenance. It is a common strategy for intracellular bacteria to exploit these pathways to shape their respective niches for survival. The subversion of Rabs for the generation of an intracellular environment favoring the pathogen has been described almost exclusively for intracellular bacteria that reside within bacterial containing vacuoles (BCVs). However, less is known about Rab subversion for bacteria that rupture the BCV to reach the host cytoplasm. Here, we provide recent examples of Rab targeting by both groups of intracellular bacteria with a special focus on Shigella, the causative agent of bacillary dysentery. Shigella recruits Rab11, the hallmark of the perinuclear recycling compartment to in situ formed macropinosomes at the entry foci via the bacterial effector IpgD. This leads to efficient BCV rupture and cytosolic escape. We discuss the concept of diverted recycling through host Rab GTPases that emerges as a novel pathogen strategy.
authors.affiliation: a Institut Pasteur, Research unit "Dynamics of host-pathogen interactions," Paris , France.
authors.forename: Noelia
authors.initials: N
authors.lastname: López-Montero
authors.affiliation: a Institut Pasteur, Research unit "Dynamics of host-pathogen interactions," Paris , France.
authors.forename: Jost
authors.initials: J
authors.lastname: Enninga
mesh_terms: D006801:Humans; D042541:Intracellular Space / Q000382:microbiology; D012760:Shigella / Q000201:enzymology* / Q000502:physiology; D014617:Vacuoles / Q000378:metabolism; D020691:rab GTP-Binding Proteins / Q000378:metabolism*
chemical_list: D020691:rab GTP-Binding Proteins
keywords: Rab subversion; Rab11; Shigella flexneri; bacterial containing vacuole; intracellular bacteria; macropinocytosis; vacuolar rupture; vesicular traffic