title: The molecular and genetic aspects of adolescent girls anomalous uterine bleeding: the role of endothelial dysfunction syndrome.
abstract: The objective of the study is to assess NOS3 and ESR1 gene polymorphism in adolescent girls born with low birth weight (LBW) and suffered by anomalous uterine bleeding (AUB). A total 95 adolescent girls were studied including 32 born with LBW and AUB; 36 girls with normal birth weight and AUB; and 27 healthy girls. Single allele gene polymorphism NOS3 786T > C, 894G > T, ESR1 351A > G and 397T > C was studied. The existence of polymorphous allele С gene NOS3 786Т > С (for homozygote OR = 2.03; 95% CI: 1.12-3.68; p = 0.04; for heterozygote OR = 1.68; 95% CI: 1.09-2.60; p = 0.046) and genotype Pvull-CC ESR1 (OR = 4.58; 95% CI: 0.97-21.68; p = 0.04) was detected in LBW girls with AUB. It was suggested that intrauterine programming of endothelial dysfunction syndrome could play a significant role in the development of AUB in adolescent girls born with LBW.
authors.affiliation: a Federal State Budgetary Institution (FSBU) "Ural Research Institute for Maternal and Child Care" Ministry of Health of the Russian Federation , Yekaterinburg , Russia and.
authors.forename: O A
authors.initials: OA
authors.lastname: Melkozerova
authors.affiliation: a Federal State Budgetary Institution (FSBU) "Ural Research Institute for Maternal and Child Care" Ministry of Health of the Russian Federation , Yekaterinburg , Russia and.
authors.forename: N V
authors.initials: NV
authors.lastname: Bashmakova
authors.affiliation: a Federal State Budgetary Institution (FSBU) "Ural Research Institute for Maternal and Child Care" Ministry of Health of the Russian Federation , Yekaterinburg , Russia and.
authors.forename: E V
authors.initials: EV
authors.lastname: Volkova
authors.affiliation: a Federal State Budgetary Institution (FSBU) "Ural Research Institute for Maternal and Child Care" Ministry of Health of the Russian Federation , Yekaterinburg , Russia and.
authors.forename: T B
authors.initials: TB
authors.lastname: Tretyakova
authors.affiliation: a Federal State Budgetary Institution (FSBU) "Ural Research Institute for Maternal and Child Care" Ministry of Health of the Russian Federation , Yekaterinburg , Russia and.|b Ural State Medical University , Yekaterinburg , Russia.
authors.forename: P B
authors.initials: PB
authors.lastname: Tsyvian
mesh_terms: D000293:Adolescent; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D014592:Uterine Hemorrhage / Q000235:genetics*
chemical_list: C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III
keywords: Anomalous uterine bleeding in adolescent girls; NOS3 and ESR1 gene polymorphism; intrauterine growth restriction