title: Radiographic changes of the distal phalangeal tuft of the hands in subjects with systemic sclerosis. Systematic review.
abstract: OBJECTIVE
  To determine abnormal plain radiograph findings of the distal phalanx tuft of the hand (DPTH) associated with systemic sclerosis in adults.
  
  
  METHODS
  A systematic review was developed following the parameters of the PRISMA guidelines in databases: MEDLINE, EMBASE, BIREME, Scielo, Google Scholar and others including as primary outcomes alterations of DPTH (erosions, resorption, sclerosis and proliferation) detected by simple radiography in subjects with systemic sclerosis. The prevalence of radiographic findings was synthesized using the fixed effects model. The statistical associations were expressed in terms of relative risk or odds ratio with their respective confidence intervals and p values.
  
  
  RESULTS
  Twenty-two observational studies were included; the prevalence of DPTH resorption was 28.3% (95% CI: 0.256-0.312; p < .001); I2=80.4%, the prevalence of calcinosis was 15.6% (95% CI: 0.113-0.210; p < .001); I2=0%. No study reported proliferation or erosions and only one study described sclerosis of DPTH in 5 individuals.
  
  
  CONCLUSIONS
  Resorption and calcinosis of DPTH are the characteristic radiographic findings in patients with systemic sclerosis. However, new studies with greater methodological strength are needed to establish associations between these phenomena and their presence in other connective tissue diseases.
authors.affiliation: Departamento de imágenes diagnósticas, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá D.C., Colombia; Grupo de Investigación en Radiología e Imágenes Diagnósticas (GRID), Bogotá D.C., Colombia. Electronic address: yeaguirrei@unal.edu.co.
authors.forename: Yojhan Edilberto
authors.initials: YE
authors.lastname: Izquierdo
authors.affiliation: Departamento de imágenes diagnósticas, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá D.C., Colombia; Grupo de Investigación en Radiología e Imágenes Diagnósticas (GRID), Bogotá D.C., Colombia.
authors.forename: Enrique
authors.initials: E
authors.lastname: Calvo Páramo
authors.affiliation: Departamento de imágenes diagnósticas, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá D.C., Colombia; Grupo de Investigación en Radiología e Imágenes Diagnósticas (GRID), Bogotá D.C., Colombia.
authors.forename: Luisa María
authors.initials: LM
authors.lastname: Castañeda
authors.affiliation: Grupo de Investigación en Radiología e Imágenes Diagnósticas (GRID), Bogotá D.C., Colombia.
authors.forename: Sandra Viviana
authors.initials: SV
authors.lastname: Gómez
authors.affiliation: Grupo de Investigación en Radiología e Imágenes Diagnósticas (GRID), Bogotá D.C., Colombia.
authors.forename: Fernán Santiago
authors.initials: FS
authors.lastname: Zambrano
mesh_terms: D002114:Calcinosis / Q000000981:diagnostic imaging; D050278:Finger Phalanges / Q000000981:diagnostic imaging*; D006801:Humans; D011859:Radiography; D012595:Scleroderma, Systemic / Q000000981:diagnostic imaging*
keywords: Esclerosis sistémica; Falanges de los dedos; Finger phalanges; Hand; Manos; Radiografía; Radiography; Scleroderma systemic