title: Haemostatic disorders in reproductive age women with menorrhagia and effects on quality of life.
abstract: The aim of this study was to determine the frequency of haemostatic abnormalities in women with menorrhagia and to evaluate their effect on quality of life (QoL). The study population was composed of patients with menorrhagia seen in the outpatient clinic, having a score of >185 with a pictorial blood assessment chart. Structured questionnaires were used in the assessment of demographic characteristics and QoL, and patients were tested for bleeding disorders. Ninety women were recruited for the study. Bleeding disorders were detected in 40% of them: 11.1% had von Willebrand disease, 2.2% had low von Willebrand factor and 26.7% had platelet function disorders (PFD). In 22 (91.6%) cases with PFD the, defect was non-specific and impaired aggregation response to ristocetine (37.5%) was the most commonly detected problem. Bleeding disorders were not associated with any significant reduction in QoL (p > .05). Hereditary bleeding disorders may be the cause of unexplained menorrhagia even in the middle-aged women, but they had no prominent effect on QoL.
authors.affiliation: a Department of Hematology , Pamukkale University, Faculty of Medicine , Denizli , Turkey.
authors.forename: Sibel
authors.initials: S
authors.lastname: Hacioglu
authors.affiliation: b Department of Obstetrics and Gynecology , Pamukkale University, Faculty of Medicine , Denizli , Turkey.
authors.forename: Aysun
authors.initials: A
authors.lastname: Karabulut
authors.affiliation: a Department of Hematology , Pamukkale University, Faculty of Medicine , Denizli , Turkey.
authors.forename: Ismail
authors.initials: I
authors.lastname: Sari
authors.affiliation: a Department of Hematology , Pamukkale University, Faculty of Medicine , Denizli , Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Keskin
mesh_terms: D000293:Adolescent; D000328:Adult; D001791:Blood Platelet Disorders / Q000523:psychology*; D005260:Female; D020141:Hemostatic Disorders / Q000523:psychology*; D006801:Humans; D008595:Menorrhagia / Q000209:etiology / Q000523:psychology*; D008875:Middle Aged; D011788:Quality of Life; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Menorrhagia; platelet function disorder; quality of life; von Willebrand disease