title: Hepatitis B virus infection in Chinese patients with hepatitis C virus infection: prevalence, clinical characteristics, viral interactions and host genotypes: a nationwide cross-sectional study.
abstract: Little is known about hepatitis B virus (HBV) infection in patients with hepatitis C virus (HCV) infection in China. This study aimed to evaluate the prevalence, clinical characteristics, viral interactions and host genotypes of HBV/HCV dual infection compared with HCV monoinfection.
  
  
  
  A cross-sectional study.
  
  
  
  China.
  
  
  
  997 patients with HCV from 28 university-affiliated hospitals in China were enrolled in this research. Patients were divided into two subgroups.
  
  
  
  The prevalence of HBV infection in patients with HCV was 4.11% (41/997). The age-specific prevalence of HBsAg was 0.70%, 3.97% and 5.85% in groups aged 18-30, 30-50 and >50 years old (p=0.057), respectively. Patients with HBV/HCV dual infection and patients with HCV monoinfection had similar HCV viral loads (5.80±0.89 vs 5.83±1.00 log10 IU/mL, p=0.904). The dominant HCV genotype was 1b in both groups (53.65% vs 56.90%, p=0.493). The protective C allele in IL-28B (rs12979860) was also the dominant allele type in both patient groups (85.36% vs 83.99%, p=0.814). Patients with HBV/HCV dual infection had a higher ratio of liver cirrhosis and hepatic decompensation than patients with HCV monoinfection (39.02% vs 17.69%, p=0.001; 31.70% vs 12.13%, p=0.001).
  
  
  
  The HBV burden was moderate in HCV-infected patients in China. Liver cirrhosis was more common in patients with HBV/HCV dual infection, suggesting the need for closer monitoring of dual-infected individuals.
  
  
  
  NCT01293279; Post-results.
authors.affiliation: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, People's Republic of China Division of Infectious Diseases, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, People's Republic of China.
authors.forename: Li-Bo
authors.initials: LB
authors.lastname: Yan
authors.affiliation: Beijing Key Laboratory for Hepatitis C and Immunotherapy for Liver Disease, Peking University People's Hospital, Peking University Hepatology Institute, Beijing, People's Republic of China.
authors.forename: Hui-Ying
authors.initials: HY
authors.lastname: Rao
authors.affiliation: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, People's Republic of China Division of Infectious Diseases, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, People's Republic of China.
authors.forename: Yuan-Ji
authors.initials: YJ
authors.lastname: Ma
authors.affiliation: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, People's Republic of China Division of Infectious Diseases, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, People's Republic of China.
authors.forename: Lang
authors.initials: L
authors.lastname: Bai
authors.affiliation: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, People's Republic of China Division of Infectious Diseases, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, People's Republic of China.
authors.forename: En-Qiang
authors.initials: EQ
authors.lastname: Chen
authors.affiliation: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, People's Republic of China Division of Infectious Diseases, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, People's Republic of China.
authors.forename: Ling-Yao
authors.initials: LY
authors.lastname: Du
authors.affiliation: Beijing Key Laboratory for Hepatitis C and Immunotherapy for Liver Disease, Peking University People's Hospital, Peking University Hepatology Institute, Beijing, People's Republic of China.
authors.forename: Rui-Feng
authors.initials: RF
authors.lastname: Yang
authors.affiliation: Beijing Key Laboratory for Hepatitis C and Immunotherapy for Liver Disease, Peking University People's Hospital, Peking University Hepatology Institute, Beijing, People's Republic of China.
authors.forename: Lai
authors.initials: L
authors.lastname: Wei
authors.affiliation: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, People's Republic of China Division of Infectious Diseases, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, People's Republic of China.
authors.forename: Hong
authors.initials: H
authors.lastname: Tang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People; D002681:China / Q000453:epidemiology; D060085:Coinfection / Q000453:epidemiology* / Q000235:genetics / Q000821:virology; D003430:Cross-Sectional Studies; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics / Q000472:pathogenicity*; D006509:Hepatitis B / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000821:virology; D006515:Hepatitis B virus / Q000235:genetics / Q000472:pathogenicity*; D006526:Hepatitis C / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000821:virology; D006801:Humans; D007372:Interferons; D007378:Interleukins / Q000378:metabolism; D008103:Liver Cirrhosis / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D055815:Young Adult; D000095022:Interferon Lambda
chemical_list: D007372:Interferons; D007378:Interleukins; C000624353:interferon-lambda, human; D000095022:Interferon Lambda
keywords: Cirrhosis; Hepatitis; Hepatitis B virus (HBV); Hepatitis C virus (HCV)