title: Individualized Acupuncture for Symptom Relief in Functional Dyspepsia: A Randomized Controlled Trial.
abstract: OBJECTIVE
  This study was implemented to evaluate the effect of individualized acupuncture treatment (AT) on functional dyspepsia (FD).
  
  
  METHODS
  A randomized, waitlist-controlled, two-center trial was performed. Seventy-six patients with FD were enrolled in the trial with partially individualized AT in a more realistic clinical setting performed twice a week for 15 minutes a session over 4 weeks. The participants were randomly allocated to a group receiving 8 sessions of AT for 4 weeks or a waitlist control group. After 4 consecutive weeks, the AT group was followed up without AT and the control group received the identical AT. The proportion of responders with adequate symptom relief, Nepean Dyspepsia Index (NDI), FD-related quality of life, Beck Depression Inventory, State-Trait Anxiety Inventory, Acupuncture Belief Scale, and acupuncture credibility test were assessed.
  
  
  RESULTS
  After the first 4 weeks, the proportion of responders significantly improved (59% in AT group [n = 37] versus 3% in control group [n = 39]; p < 0.001). The difference was no longer significant at 8 weeks, at which point the waitlist control group showed similar improvement after receiving AT (68% in the AT group versus 79% in the control group). Total NDI scores were significantly reduced in the AT group compared with the waitlist group (p = 0.03). Among NDI items, discomfort (p = 0.01), burning (p = 0.02), fullness after eating (p = 0.02), and burping (p = 0.02) were significantly improved in the AT group compared with the control group. No significant differences were observed between groups in other secondary variables.
  
  
  CONCLUSIONS
  Individualized AT adequately relieves symptoms in patients with FD, and this effect may persist up to 8 weeks.
authors.affiliation: 1 Department of Gastroenterology, College of Korean Medicine, Kyung Hee University , Seoul, Republic of Korea.
authors.forename: Seok-Jae
authors.initials: SJ
authors.lastname: Ko
authors.affiliation: 2 Department of Gastroenterology, Center for Neurointestinal Health , Massachusetts General Hospital, Harvard Medical School, Boston, MA.
authors.forename: Braden
authors.initials: B
authors.lastname: Kuo
authors.affiliation: 1 Department of Gastroenterology, College of Korean Medicine, Kyung Hee University , Seoul, Republic of Korea.
authors.forename: Seul-Ki
authors.initials: SK
authors.lastname: Kim
authors.affiliation: 3 Acupuncture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University , Seoul, Republic of Korea.
authors.forename: Hyangsook
authors.initials: H
authors.lastname: Lee
authors.affiliation: 1 Department of Gastroenterology, College of Korean Medicine, Kyung Hee University , Seoul, Republic of Korea.
authors.forename: Jinsung
authors.initials: J
authors.lastname: Kim
authors.affiliation: 1 Department of Gastroenterology, College of Korean Medicine, Kyung Hee University , Seoul, Republic of Korea.
authors.forename: Gajin
authors.initials: G
authors.lastname: Han
authors.affiliation: 1 Department of Gastroenterology, College of Korean Medicine, Kyung Hee University , Seoul, Republic of Korea.
authors.forename: Juyeon
authors.initials: J
authors.lastname: Kim
authors.affiliation: 3 Acupuncture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University , Seoul, Republic of Korea.
authors.forename: Song-Yi
authors.initials: SY
authors.lastname: Kim
authors.affiliation: 1 Department of Gastroenterology, College of Korean Medicine, Kyung Hee University , Seoul, Republic of Korea.
authors.forename: Seungwon
authors.initials: S
authors.lastname: Jang
authors.affiliation: 1 Department of Gastroenterology, College of Korean Medicine, Kyung Hee University , Seoul, Republic of Korea.
authors.forename: Jiyoung
authors.initials: J
authors.lastname: Son
authors.affiliation: 1 Department of Gastroenterology, College of Korean Medicine, Kyung Hee University , Seoul, Republic of Korea.
authors.forename: Minji
authors.initials: M
authors.lastname: Kim
authors.affiliation: 3 Acupuncture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University , Seoul, Republic of Korea.
authors.forename: Hyejung
authors.initials: H
authors.lastname: Lee
authors.affiliation: 4 Department of Statistics, Sookmyung Women's University , Seoul, Republic of Korea.
authors.forename: Inkwon
authors.initials: I
authors.lastname: Yeo
authors.affiliation: 5 Department of Gastroenterology, School of Medicine, Kyung Hee University , Seoul, Republic of Korea.
authors.forename: Kwang Ro
authors.initials: KR
authors.lastname: Joo
authors.affiliation: 1 Department of Gastroenterology, College of Korean Medicine, Kyung Hee University , Seoul, Republic of Korea.
authors.forename: Jae-Woo
authors.initials: JW
authors.lastname: Park
mesh_terms: D015670:Acupuncture Therapy; D000328:Adult; D004415:Dyspepsia / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
keywords: CAM; acupuncture; alternative therapy