title: A PRISMA-compliant meta-analysis of MDM4 genetic variants and cancer susceptibility.
abstract: Molecular epidemiological research suggests that mouse double minute 4 (MDM4) polymorphisms may be associated with cancer susceptibility, but results remain controversial. To derive a more precise evaluation, we performed a PRISMA compliant meta-analysis focused on five single nucleotide polymorphisms (rs11801299, rs1380576, rs10900598, rs1563828, and rs4245739) of MDM4. Overall, 23 studies involving 22,218 cases and 55,033 controls were analyzed. The results showed that rs4245739 was significantly associated with a decreased cancer risk in the allelic (C vs. A: odds ratio [OR] = 0.848, 95% confidence interval [CI] = 0.765-0.941, P = 0.002), heterozygous (AC vs. AA: OR = 0.831, 95% CI = 0.735-0.939, P = 0.003), and dominant (AC+CC vs. A: OR = 0.823, 95% CI = 0.727-0.932, P = 0.002) models. The association was more prominent in Asians. No significant association was found using any genetic model for the rs11801299, rs1380576, rs10900598, and rs1563828 SNPs. These results indicate that the rs4245739 polymorphism may contribute to a decreased cancer susceptibility and support the hypothesis that genetic variants in the MDM4 genes act as important modifiers of cancer risk.
authors.affiliation: Department of Pharmacy, the First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
authors.forename: Yajing
authors.initials: Y
authors.lastname: Zhai
authors.affiliation: Department of Oncology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Dai
authors.affiliation: Clinical Research Center, the First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
authors.forename: Hairong
authors.initials: H
authors.lastname: He
authors.affiliation: Clinical Research Center, the First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Gao
authors.affiliation: Clinical Research Center, the First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
authors.forename: Lihong
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Pharmacy, the First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
authors.forename: Yalin
authors.initials: Y
authors.lastname: Dong
authors.affiliation: Clinical Research Center, the First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Lu
mesh_terms: D000483:Alleles; D018797:Cell Cycle Proteins; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D016017:Odds Ratio; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D017594:Publication Bias; D012306:Risk
chemical_list: D018797:Cell Cycle Proteins; C482775:MDM4 protein, human; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins
keywords: MDM4; cancer susceptibility; meta-analysis; polymorphism