title: Association between radical prostatectomy and risk of herpes zoster.
abstract: The present study investigated the association between radical prostatectomy (RP) and the risk of herpes zoster (HZ). Male patients aged ≥ 40 years and diagnosed with prostate cancer (PCa) between 2000 and 2005 were included in this study. Patients who underwent RP for the first time during 2000-2006 were included in the RP group. Randomly selected individuals from among the remaining patients with PCa who did not undergo RP were included in the non-RP group. Univariate and multivariate Cox regression models were used to analyze the association between PCa and HZ. In addition, the association between RP and the risk of HZ in different subgroups was evaluated after stratification by age, comorbidities, and hormone therapy (HoT) status. Furthermore, the combined effect of RP and HoT on the risk of HZ was evaluated. This study included 1,380 patients with PCa who newly underwent RP and 1,371 patients with PCa who did not undergo RP. During follow-up, 96 and 104 patients in the RP and non-RP groups, respectively, developed HZ. Patients who underwent both RP and HoT showed a significantly reduced risk of HZ, compared with patients who did not undergo both RP and HoT. RP is not associated with an increased risk of HZ. However, prostate-specific antigen levels should be monitored routinely during follow-up to detect PCa recurrence.
authors.affiliation: Department of Family Medicine, Puli Christian Hospital, Puli, Taiwan.|Department of Medical Education and Research, Puli Christian Hospital, Puli, Taiwan.|Center for General Education, National Chi Nan University, Puli, Taiwan.|Department of Optometry, Central Taiwan University of Science and Technology, Taichung, Taiwan.|Center for General Education, National Taichung University of Science and Technology, Taichung, Taiwan.|Center for General Education, Feng Chia University, Taichung, Taiwan.|Department of General Education, National Chin-Yi University of Technology, Taichung, Taiwan.|The General Education Center, Chaoyang University of Technology, Taichung, Taiwan.
authors.forename: C-Y
authors.initials: CY
authors.lastname: Hsu
authors.affiliation: Department of Surgery, Division of Thoracic Surgery, China Medical University Hospital, Taichung, Taiwan.
authors.forename: P-R
authors.initials: PR
authors.lastname: Chen
authors.affiliation: Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.|College of Medicine, China Medical University, Taichung, Taiwan.
authors.forename: H-J
authors.initials: HJ
authors.lastname: Chen
authors.affiliation: Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, No. 2, Yuh-Der Road, Taichung, 40447, Taiwan. d4615@mail.cmuh.org.tw.|Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan. d4615@mail.cmuh.org.tw.
authors.forename: J-A
authors.initials: JA
authors.lastname: Liang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006562:Herpes Zoster / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000150:complications* / Q000601:surgery; D012189:Retrospective Studies; D018570:Risk Assessment