title: Associations between Periodontal Microbiota and Death Rates.
abstract: It is conceived that specific combinations of periodontal bacteria are associated with risk for the various forms of periodontitis. We hypothesized that such specificity is also related to human cause-specific death rates. We tested this hypothesis in a representative sample of the US population followed for a mean duration of 11 years and found that two specific patterns of 21 serum antibodies against periodontal bacteria were significantly associated with increased all-cause and/or diabetes-related mortalities. These data suggested that specific combinations of periodontal bacteria, even without inducing clinically significant periodontitis, may have a significant impact on human cause-specific death rates. Our findings implied that increased disease and mortality risk could be transmittable via the transfer of oral microbiota, and that developing personalized strategies and maintaining healthy oral microbiota beyond protection against periodontitis would be important to manage the risk.
authors.affiliation: Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
authors.forename: Chung-Jung
authors.initials: CJ
authors.lastname: Chiu
authors.affiliation: Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
authors.forename: Min-Lee
authors.initials: ML
authors.lastname: Chang
authors.affiliation: Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
authors.forename: Allen
authors.initials: A
authors.lastname: Taylor
mesh_terms: D000368:Aged; D000907:Antibodies, Bacterial / Q000276:immunology; D015415:Biomarkers; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006306:Health Surveys; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D016018:Least-Squares Analysis; D008297:Male; D064307:Microbiota / Q000276:immunology; D009026:Mortality; D010518:Periodontitis / Q000453:epidemiology / Q000382:microbiology* / Q000401:mortality*; D016016:Proportional Hazards Models; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
chemical_list: D000907:Antibodies, Bacterial; D015415:Biomarkers; D007074:Immunoglobulin G