title: Magnetic Resonance Parkinsonism Index: diagnostic accuracy of a fully automated algorithm in comparison with the manual measurement in a large Italian multicentre study in patients with progressive supranuclear palsy.
abstract: OBJECTIVE
  To investigate the reliability of a new in-house automatic algorithm for calculating the Magnetic Resonance Parkinsonism Index (MRPI), in a large multicentre study population of patients affected by progressive supranuclear palsy (PSP) or Parkinson's disease (PD), and healthy controls (HC), and to compare the diagnostic accuracy of the automatic and manual MRPI values.
  
  
  METHODS
  The study included 88 PSP patients, 234 PD patients and 117 controls. MRI was performed using both 3T and 1.5T scanners. Automatic and manual MRPI values were evaluated, and accuracy of both methods in distinguishing PSP from PD and controls was calculated.
  
  
  RESULTS
  No statistical differences were found between automated and manual MRPI values in all groups. The automatic MRPI values differentiated PSP from PD with an accuracy of 95 % (manual MRPI accuracy 96 %) and 97 % (manual MRPI accuracy 100 %) for 1.5T and 3T scanners, respectively.
  
  
  CONCLUSIONS
  Our study showed that the new in-house automated method for MRPI calculation was highly accurate in distinguishing PSP from PD. Our automatic approach allows a widespread use of MRPI in clinical practice and in longitudinal research studies.
  
  
  CONCLUSIONS
  • A new automatic method for calculating the MRPI is presented. • Automatic MRPI values are in good agreement with manual values. • Automatic MRPI can distinguish patients with PSP from patients with PD. • The automatic method overcomes MRPI application limitations in routine practice. • The automatic method may allow a more widespread use of MRPI.
authors.affiliation: Institute of Bioimaging and Molecular Physiology, National Research Council, 88100, Catanzaro, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Nigro
authors.affiliation: Institute of Neurology, Department of Medical and Surgical Sciences, University 'Magna Graecia', 88100, Catanzaro, Italy.
authors.forename: Gennarina
authors.initials: G
authors.lastname: Arabia
authors.affiliation: Parkinson's Disease and Movement Disorders Unit, 'Fondazione Ospedale San Camillo' - I.R.C.C.S, Venice-Lido, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Antonini
authors.affiliation: Parkinson's Disease and Movement Disorders Unit, 'Fondazione Ospedale San Camillo' - I.R.C.C.S, Venice-Lido, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Weis
authors.affiliation: Parkinson's Disease and Movement Disorders Unit, 'Fondazione Ospedale San Camillo' - I.R.C.C.S, Venice-Lido, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Marcante
authors.affiliation: Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, 80138, Italy.|MRI Research Center SUN-FISM, Second University of Naples, Naples, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Tessitore
authors.affiliation: Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, 80138, Italy.|MRI Research Center SUN-FISM, Second University of Naples, Naples, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Cirillo
authors.affiliation: Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, 80138, Italy.|MRI Research Center SUN-FISM, Second University of Naples, Naples, Italy.
authors.forename: Gioacchino
authors.initials: G
authors.lastname: Tedeschi
authors.affiliation: Functional MR Unit, Policlinico S. Orsola - Malpighi, Bologna, Italy.|Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Zanigni
authors.affiliation: Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.|IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Calandra-Buonaura
authors.affiliation: Functional MR Unit, Policlinico S. Orsola - Malpighi, Bologna, Italy.|Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Tonon
authors.affiliation: Parkinson Institute, ASST G.Pini - CTO, ex ICP, Milano, Italy.
authors.forename: Gianni
authors.initials: G
authors.lastname: Pezzoli
authors.affiliation: Parkinson Institute, ASST G.Pini - CTO, ex ICP, Milano, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Cilia
authors.affiliation: Department 'G.F. Ingrassia', Section of Neurosciences, University of Catania, Catania, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Zappia
authors.affiliation: Department 'G.F. Ingrassia', Section of Neurosciences, University of Catania, Catania, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Nicoletti
authors.affiliation: Department 'G.F. Ingrassia', Section of Neurosciences, University of Catania, Catania, Italy.
authors.forename: Calogero Edoardo
authors.initials: CE
authors.lastname: Cicero
authors.affiliation: Department of Neurological and Movement Sciences, University Hospital of Verona, Piazzale L.A. Scuro 10, 37134, Verona, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Tinazzi
authors.affiliation: Department of Neurological and Movement Sciences, University Hospital of Verona, Piazzale L.A. Scuro 10, 37134, Verona, Italy.
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Tocco
authors.affiliation: Institute of Radiology, University Hospital of Verona, Piazzale L.A. Scuro 10, 37134, Verona, Italy.
authors.forename: Nicolò
authors.initials: N
authors.lastname: Cardobi
authors.affiliation: Institute of Bioimaging and Molecular Physiology, National Research Council, 88100, Catanzaro, Italy. quattrone@unicz.it.|Institute of Neurology, Department of Medical and Surgical Sciences, University 'Magna Graecia', 88100, Catanzaro, Italy. quattrone@unicz.it.
authors.forename: Aldo
authors.initials: A
authors.lastname: Quattrone
mesh_terms: D000368:Aged; D000465:Algorithms; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000592:standards; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013494:Supranuclear Palsy, Progressive / Q000175:diagnosis*
keywords: Automatic segmentation; Magnetic Resonance Parkinsonism Index; Neurodegenerative disease; Parkinson’s disease; Progressive supranuclear palsy