title: Thyroid Autoimmunity and Reproductive Function.
abstract: Thyroid hormones are important for normal reproductive function, and maternal thyroid dysfunction has been associated with infertility, miscarriage, preterm birth, and poor neurodevelopment in the offspring. Thyroid autoimmunity is the leading cause of thyroid dysfunction in women of reproductive age. Women with thyroid autoimmunity, even with normal thyroid function, appear to be at a higher risk for poor reproductive outcomes, including miscarriage and preterm birth. Thyroxine replacement in women with thyroid autoimmunity with or without appreciable thyroid dysfunction may improve pregnancy outcomes. Thus, identification and treatment of women with thyroid autoimmunity may optimize reproductive success.
authors.affiliation: Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina.
authors.forename: Natalie M
authors.initials: NM
authors.lastname: Crawford
authors.affiliation: Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina.
authors.forename: Anne Z
authors.initials: AZ
authors.lastname: Steiner
mesh_terms: D000022:Abortion, Spontaneous / Q000276:immunology; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000276:immunology; D008403:Mass Screening; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology*; D011256:Pregnancy Outcome; D012098:Reproduction; D013959:Thyroid Diseases / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D013961:Thyroid Gland / Q000276:immunology*; D013974:Thyroxine / Q000097:blood / Q000276:immunology* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D013974:Thyroxine