title: Recent discoveries concerning the tumor - mesenchymal stem cell interactions.
abstract: Tumor microenvironment plays a crucial role in coordination with cancer cells in the establishment, growth and dissemination of the tumor. Among cells of the microenvironment, mesenchymal stem cells (MSCs) and their ability to evolve into cancer associated fibroblasts (CAFs) have recently generated a major interest in the field. Numerous studies have described the potential pro- or anti-tumorigenic action of MSCs. The goal of this review is to synthesize recent and emerging discoveries concerning the mechanisms by which MSCs can be attracted to tumor sites, how they can generate CAFs and by which way MSCs are able to modulate the growth, response to treatments, angiogenesis, invasion and metastasis of tumors. The understanding of the role of MSCs in tumor development has potential and clinical applications in terms of cancer management.
authors.affiliation: CNRS, SYS2DIAG, Cap delta, 1682 rue de la Valsière, Montpellier F-34184, France; CNRS, GDR 3697 "Microenvrionment of tumor niches", Micronit, France. Electronic address: gwendal.lazennec@sys2diag.cnrs.fr.
authors.forename: Gwendal
authors.initials: G
authors.lastname: Lazennec
authors.affiliation: Division of Cellular and Molecular Research, National Cancer Centre, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore; Cancer and Stem Cells Biology Program, Duke-NUS Graduate Medical School, Singapore 169857, Singapore. Electronic address: cmrlyp@nccs.com.sg.
authors.forename: Paula Y
authors.initials: PY
authors.lastname: Lam
mesh_terms: D000818:Animals; D017209:Apoptosis; D000072645:Cancer-Associated Fibroblasts / Q000502:physiology; D002450:Cell Communication; D049109:Cell Proliferation; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D009369:Neoplasms / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D018919:Neovascularization, Physiologic; D059016:Tumor Microenvironment
keywords: Chemokines; Cytokines; Mesenchymal stem cells; Tumor microenvironment