title: Prostate Specific Antigen-Positive Deceased Organ Donor: A Pathologist Is Indispensable.
abstract: BACKGROUND
  Due to demographic projections, and lack of an algorithm in the case of a prostate specific antigen (PSA)-positive donor, the loss of organ recovery may occur more frequently in the near future without approved procedures. In Poland in recent years it has been recommended to determine tumor markers in potential donors. In the first year of the recommendation 10% of potential deceased donors were disqualified in our transplantation center on the basis of the elevated PSA levels (high PSA >10 ng/mL). Histopathologic evaluation of prostate was implemented in a donor qualification procedure to prevent reduction of the actual organ donor pool.
  
  
  METHODS
  In the period of January 2010-January 2014 each donor reported to a coordination center (n = 52; median age, 54 years) and underwent the routine histological evaluation of the whole prostate, regardless of the PSA level.
  
  
  RESULTS
  Pathologist revealed in the study group of 52 male donors, 6 cases of carcinoma of the prostate (CaP; 12%). There was no correlation between PSA level and CaP (-)/CaP(+) (median 7.0 vs 3.9 ng/mL, respectively; P = .51) nor high-grade prostate intraepithelial neoplasia (HGPIN) (+)/HGPIN (-) (median 5.9 vs 4.3 ng/mL; P = .14). All of the recovered organs (12 kidneys and 3 livers) from donors with CaP were transplanted, resulting in a 15% increase in the organ donor pool.
  
  
  CONCLUSIONS
  There is no association between PSA values and CaP occurrence in deceased organ donors. Histological verification allowed for an increase in the organ pool with maintenance of safety standards.
authors.affiliation: Department of Nephrology Transplantation and Internal Medicine, Pomeranian Medical University, Szczecin, Poland. Electronic address: bkpn@pum.edu.pl.
authors.forename: K
authors.initials: K
authors.lastname: Pabisiak
authors.affiliation: Department of General Surgery and Transplantation, Pomeranian Medical University, Szczecin, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Ostrowski
authors.affiliation: West Pomeranian Oncology Center, Szczecin, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Kram
authors.affiliation: Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Safranow
authors.affiliation: Department of Urology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Słojewski
authors.affiliation: Department of Nephrology Transplantation and Internal Medicine, Pomeranian Medical University, Szczecin, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Ciechanowski
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D014408:Biomarkers, Tumor / Q000097:blood*; D002983:Clinical Competence / Q000592:standards; D006801:Humans; D008297:Male; D008875:Middle Aged; D000072142:Pathologists / Q000592:standards*; D011044:Poland; D011467:Prostate / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000097:blood*; D019048:Prostatic Intraepithelial Neoplasia / Q000473:pathology; D011471:Prostatic Neoplasms / Q000473:pathology; D014019:Tissue Donors / Q000600:supply & distribution; D009927:Tissue and Organ Procurement / Q000379:methods*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen