title: [Association of the -844G>A polymorphism in the catalase gene with the increased risk of essential hypertension in smokers].
abstract: OBJECTIVE
  To investigate whether the functionally relevant -844G>A promotor polymorphism in the catalase (CAT) gene is associated with the development of essential hypertension (EH).
  
  
  METHODS
  The investigation enrolled 2,339 unrelated ethnic Russian people, including 1,269 EH patients and 770 apparently healthy individuals. Genotyping of CAT -844G>A (rs769214) polymorphism was performed using a TaqMan real-time polymerase chain reaction assay.
  
  
  RESULTS
  The -844A allele (odds ratio (OR)=1.31; 95% confidence interval (CI), 1.04 to 1.64; р=0.02) and the -844AA genotype (OR=1.41; 95% CI, 1.02 to 1.94; р=0.03) were found to be related to a higher risk of EH in the smokers. No association was found between this polymorphism and EH risk in the non-smokers.
  
  
  CONCLUSIONS
  Smoking is a predisposing factor for development of EH in CAT -844AA genotype carriers.
authors.affiliation: Kursk State Medical University, Ministry of Health of Russia, Kursk, Russia.
authors.forename: O Yu
authors.initials: OY
authors.lastname: Bushueva
authors.affiliation: Kursk State Medical University, Ministry of Health of Russia, Kursk, Russia.
authors.forename: V P
authors.initials: VP
authors.lastname: Ivanov
authors.affiliation: Kursk State Medical University, Ministry of Health of Russia, Kursk, Russia.
authors.forename: V N
authors.initials: VN
authors.lastname: Ryzhaeva
authors.affiliation: Kursk State Medical University, Ministry of Health of Russia, Kursk, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Ponomarenko
authors.affiliation: Belgorod National Research University, Belgorod, Russia.
authors.forename: M I
authors.initials: MI
authors.lastname: Churnosov
authors.affiliation: Kursk State Medical University, Ministry of Health of Russia, Kursk, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Polonikov
mesh_terms: D000075222:Essential Hypertension; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000523:psychology; D008297:Male; D008875:Middle Aged; D012426:Russia; D012907:Smoking / Q000235:genetics / Q000503:physiopathology