title: Type III Secreted Virulence Factors Manipulating Signaling to Actin Dynamics.
abstract: A key aspect of bacterial pathogenesis is the colonization and persistence within the host and, later on, its dissemination to new niches. During evolution, bacteria developed a myriad of virulence mechanisms to usurp the host's sophisticated defense mechanisms in order to establish their colonization niche. Elucidation of the highly dynamic and complex interactions between host and pathogens remains an important field of study. Here, we highlight the conserved manipulation of the actin cytoskeleton by some Gram-negative gastrointestinal pathogens, addressing the role of type III secreted bacterial GEFs at the different steps of pathogenesis. As a final topic, we review cytoskeleton dynamics induced by EPEC/EHEC strains for pedestal formation.
authors.affiliation: Department of Cell Biology, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124, Baunschweig, Germany. theresia.stradal@helmholz-hzi.de.
authors.forename: Theresia E B
authors.initials: TE
authors.lastname: Stradal
authors.affiliation: Department of Cell Biology, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124, Baunschweig, Germany.
authors.forename: Sonia C P
authors.initials: SC
authors.lastname: Costa
mesh_terms: D000199:Actins / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001419:Bacteria / Q000235:genetics / Q000378:metabolism*; D001424:Bacterial Infections / Q000235:genetics / Q000378:metabolism* / Q000382:microbiology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D054884:Host-Pathogen Interactions; D006801:Humans; D015398:Signal Transduction; D000069296:Type III Secretion Systems / Q000235:genetics / Q000378:metabolism*; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: D000199:Actins; D001426:Bacterial Proteins; D000069296:Type III Secretion Systems; D037521:Virulence Factors