title: A fluidic circuit based, high-efficiency and large-scale single cell trap.
abstract: Single cell traps have important applications in biological cell manipulation and analysis. This paper describes a novel single cell trap design and device with a matrix of cell trap units inspired by an equivalent resistive electric circuit. This fluidic device follows the least flow resistance path principle of such devices allowing deterministic single cell trapping with high efficiency and flexibility for large scale cell patterning.
authors.affiliation: State Key Laboratory of Precision Measurement Technology and Instrument, Department of Precision Instrument, Tsinghua University, Beijing, China. wwh@tsinghua.edu.cn.
authors.forename: Lu
authors.initials: L
authors.lastname: Mi
authors.affiliation: State Key Laboratory of Precision Measurement Technology and Instrument, Department of Precision Instrument, Tsinghua University, Beijing, China. wwh@tsinghua.edu.cn.
authors.forename: Liang
authors.initials: L
authors.lastname: Huang
authors.affiliation: School of life sciences, Tsinghua University, Beijing, China.
authors.forename: Junxiang
authors.initials: J
authors.lastname: Li
authors.affiliation: State Key Laboratory of Precision Measurement Technology and Instrument, Department of Precision Instrument, Tsinghua University, Beijing, China. wwh@tsinghua.edu.cn.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Xu
authors.affiliation: School of life sciences, Tsinghua University, Beijing, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Precision Measurement Technology and Instrument, Department of Precision Instrument, Tsinghua University, Beijing, China. wwh@tsinghua.edu.cn.
authors.forename: Wenhui
authors.initials: W
authors.lastname: Wang
mesh_terms: D002469:Cell Separation; D004867:Equipment Design; D006367:HeLa Cells; D006801:Humans; D056656:Lab-On-A-Chip Devices; D059010:Single-Cell Analysis / Q000295:instrumentation*