title: Evidence of Lipid Exchange in Styrene Maleic Acid Lipid Particle (SMALP) Nanodisc Systems.
abstract: Styrene-alt-maleic acid lipid particles (SMALPs) are self-assembled discoidal structures composed of a polymer belt and a segment of lipid bilayer, which are capable of encapsulating membrane proteins directly from the cell membrane. Here we present evidence of the exchange of lipids between such "nanodiscs" and lipid monolayers adsorbed at either solid-liquid or air-liquid interfaces. This behavior has important implications for the potential uses of nanodiscs.
authors.affiliation: Department of Chemistry, University of Bath , Claverton Down, Bath BA2 7AY, United Kingdom.
authors.forename: Gavin
authors.initials: G
authors.lastname: Hazell
authors.affiliation: Diamond Light Source, Harwell Science and Innovation Campus , Didcot, OX11 ODE, United Kingdom.
authors.forename: Thomas
authors.initials: T
authors.lastname: Arnold
authors.affiliation: School of Science and Engineering, University of Dundee , Dundee, DD1 4HN, United Kingdom.
authors.forename: Robert D
authors.initials: RD
authors.lastname: Barker
authors.affiliation: ISIS Spallation Neutron Source, STFC, Harwell Science and Innovation Campus, Didcot, OX11 OQX, United Kingdom.
authors.forename: Luke A
authors.initials: LA
authors.lastname: Clifton
authors.affiliation: ISIS Spallation Neutron Source, STFC, Harwell Science and Innovation Campus, Didcot, OX11 OQX, United Kingdom.
authors.forename: Nina-Juliane
authors.initials: NJ
authors.lastname: Steinke
authors.affiliation: Department of Chemistry, University of Bath , Claverton Down, Bath BA2 7AY, United Kingdom.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Tognoloni
authors.affiliation: Department of Chemistry, University of Bath , Claverton Down, Bath BA2 7AY, United Kingdom.
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Edler