title: Monocyte Conversion During Inflammation and Injury.
abstract: Monocytes are circulating leukocytes important in both innate and adaptive immunity, primarily functioning in immune defense, inflammation, and tissue remodeling. There are 2 subsets of monocytes in mice (3 subsets in humans) that are mobilized from the bone marrow and recruited to sites of inflammation, where they carry out their respective functions in promoting inflammation or facilitating tissue repair. Our understanding of the fate of these monocyte subsets at the site of inflammation is constantly evolving. This brief review highlights the plasticity of monocyte subsets and their conversion during inflammation and injury.
authors.affiliation: From the Department of Microbiology, Immunology, and Infectious Diseases (R.M.K., P.K.) and Department of Physiology and Pharmacology (P.K., J.F.D.), Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Canada.
authors.forename: Rachel M
authors.initials: RM
authors.lastname: Kratofil
authors.affiliation: From the Department of Microbiology, Immunology, and Infectious Diseases (R.M.K., P.K.) and Department of Physiology and Pharmacology (P.K., J.F.D.), Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Canada.
authors.forename: Paul
authors.initials: P
authors.lastname: Kubes
authors.affiliation: From the Department of Microbiology, Immunology, and Infectious Diseases (R.M.K., P.K.) and Department of Physiology and Pharmacology (P.K., J.F.D.), Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Canada.
authors.forename: Justin F
authors.initials: JF
authors.lastname: Deniset
mesh_terms: D000818:Animals; D000066670:Cell Plasticity; D002634:Chemotaxis, Leukocyte; D006487:Hemostasis; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D018836:Inflammation Mediators / Q000276:immunology / Q000378:metabolism; D008264:Macrophages / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D051379:Mice; D009000:Monocytes / Q000145:classification / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D010641:Phenotype; D015398:Signal Transduction; D014945:Wound Healing
chemical_list: D018836:Inflammation Mediators
keywords: infection; inflammation; innate immunity; macrophages; monocytes