title: Proangiogenic features in chronic pelvic pain caused by adenomyosis.
abstract: OBJECTIVE
  The study of peculiarities of expression of vascular endothelial growth factor (VEGF) in the tissues of the endometrium and myometrium in patients with adenomyosis, associated with chronic pelvic pain syndrome.
  
  
  METHODS
  Uterus macro-preparations obtained after hysterectomy in 60 patients with pelvic pain on a background of diffuse adenomyosis II-III degree were used for morphological examination, and macro-preparations received from 30 women with adenomyosis without pain syndrome. The diagnosis of adenomyosis was confirmed by sonography and magnetic resonance imaging. The expression of VEGF in tissues of the endometrium and myometrium was determined using the immune-histochemical method. The significance of differences of the compared parameters was determined using the criterion of Wilcoxon and Mann-Whitney. The differences were considered statistically significant when p < 0.05.
  
  
  RESULTS
  It was found that a higher expression of VEGF is characteristic for patients with pelvic pain associated with adenomyosis, compared to women with adenomyosis and abnormal uterine bleeding, both in epithelial cells of ectopic endometrium (14.7 ± 1.6% against 10.7 ± 1.6%, p < 0.01), and in smooth myocytes of the myometrium (12.6 ± 1.4% against 9.6 ± 1.2%, p < 0.01) and in the stromal cells of the myometrium (10.1 ± 1.9% versus 7.4 ± 1.8%, p < 0.01).
  
  
  CONCLUSIONS
  An increased expression of VEGF in the tissues of the uterus is one of the most important pathogenetic mechanisms of algogenesis with adenomyosis, associated syndrome of chronic pelvic pain, compared to the silent form of the disease.
authors.affiliation: a Federal State Autonomous educational institution "Peoples' Friendship University of Russia" , Moscow , Russia and.
authors.forename: M R
authors.initials: MR
authors.lastname: Orazov
authors.affiliation: b "Odessa National Medical University" Ministry of Health of the Ukraine , Odessa , Ukraine.
authors.forename: E N
authors.initials: EN
authors.lastname: Nosenko
authors.affiliation: a Federal State Autonomous educational institution "Peoples' Friendship University of Russia" , Moscow , Russia and.
authors.forename: V E
authors.initials: VE
authors.lastname: Radzinsky
authors.affiliation: a Federal State Autonomous educational institution "Peoples' Friendship University of Russia" , Moscow , Russia and.
authors.forename: M B
authors.initials: MB
authors.lastname: Khamoshina
authors.affiliation: a Federal State Autonomous educational institution "Peoples' Friendship University of Russia" , Moscow , Russia and.
authors.forename: M G
authors.initials: MG
authors.lastname: Lebedeva
authors.affiliation: a Federal State Autonomous educational institution "Peoples' Friendship University of Russia" , Moscow , Russia and.
authors.forename: M A
authors.initials: MA
authors.lastname: Sounov
mesh_terms: D062788:Adenomyosis / Q000150:complications / Q000378:metabolism*; D059350:Chronic Pain / Q000209:etiology / Q000378:metabolism*; D005260:Female; D006801:Humans; D018919:Neovascularization, Physiologic / Q000502:physiology*; D017699:Pelvic Pain / Q000209:etiology / Q000378:metabolism*; D014599:Uterus / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A
keywords: Adenomyosis; VEGF; angiogenesis; chronic pelvic pain