title: A Successful Replacement of Phenols with Isocyanides in the Bargellini Reaction: Synthesis of 3-Carboxamido-Isobutyric Acids.
abstract: Old multicomponent reactions are still a source of inspiration for discovering novel combinations of three or more reactants. A simple idea is to replace one of the educts of a known multicomponent reaction with another functional group and still be able to mimic the same reactivity. Following this line of thought, we report a three-component reaction in which isocyanides are able to open the epoxide intermediate of the Bargellini reaction affording 3-carboxamido-isobutyric acids in yields of 47-95%.
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Napoli "Federico II" , via D. Montesano 49, 80131 Napoli, Italy.
authors.forename: Mariateresa
authors.initials: M
authors.lastname: Giustiniano
authors.affiliation: Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma , Piazzale Aldo Moro 5, I-00185 Roma, Italy.
authors.forename: Sveva
authors.initials: S
authors.lastname: Pelliccia
authors.affiliation: Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale "A. Avogadro" , Largo Donegani 2, 28100 Novara, Italy.
authors.forename: Ubaldina
authors.initials: U
authors.lastname: Galli
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Napoli "Federico II" , via D. Montesano 49, 80131 Napoli, Italy.
authors.forename: Jussara
authors.initials: J
authors.lastname: Amato
authors.affiliation: Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale "A. Avogadro" , Largo Donegani 2, 28100 Novara, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Travagin
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Napoli "Federico II" , via D. Montesano 49, 80131 Napoli, Italy.
authors.forename: Ettore
authors.initials: E
authors.lastname: Novellino
authors.affiliation: Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale "A. Avogadro" , Largo Donegani 2, 28100 Novara, Italy.
authors.forename: Gian Cesare
authors.initials: GC
authors.lastname: Tron