title: Calcium signalling and ER stress in insulin resistance and atherosclerosis.
abstract: The burden of type 2 diabetes and its major complication cardiovascular disease is rapidly increasing worldwide. Understanding the underlying pathogenic mechanisms of these diseases is crucial to develop novel therapeutics. Recent work using genetic and biochemical methods in mouse models and human samples have identified disturbed calcium signalling and endoplasmic reticulum stress as emerging factors involved in the pathogenesis of many metabolic diseases. In this review, we will highlight the specific roles of calcium signalling and endoplasmic reticulum stress response in the development of insulin resistance and atherosclerosis.
authors.affiliation: Department of Medicine, Columbia University, New York, NY, USA. lo2192@columbia.edu.
authors.forename: L
authors.initials: L
authors.lastname: Ozcan
authors.affiliation: Department of Medicine, Columbia University, New York, NY, USA.|Department of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.|Department of Pathology and Cell Biology, Columbia University, New York, NY, USA.
authors.forename: I
authors.initials: I
authors.lastname: Tabas
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D003925:Diabetic Angiopathies / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*
keywords: atherosclerosis; calcium; diabetes mellitus; insulin resistance; metabolic syndrome