title: Fortified interpenetrating polymers - bacteria resistant coatings for medical devices.
abstract: Infections arising from contaminated medical devices are a serious global issue, contributing to antibiotic resistance and imposing significant strain on healthcare systems. Since the majority of medical device-associated infections are biofilm related, efforts are being made to generate either bacteria-repellent or antibacterial coatings aimed at preventing bacterial colonisation. Here, we utilise a nanocapsule mediated slow release of a natural antimicrobial to improve the performance of a bacteria repellent polymer coating. Poly(lauryl acrylate) nanocapsules containing eugenol (4-allyl-2-methoxyphenol) were prepared and entrapped within a interpenetrating network designed to repel bacteria. When coated on a catheter and an endotracheal tube, this hemocompatible system allowed slow-release of eugenol, resulting in notable reduction in surface-boundKlebsiella pneumoniaeand methicillin resistantStaphylococcus aureus.
authors.affiliation: EaStCHEM School of Chemistry , University of Edinburgh , King's Buildings , West Mains Road , Edinburgh , EH9 3FJ , UK . Email: mark.bradley@ed.ac.uk.
authors.forename: Seshasailam
authors.initials: S
authors.lastname: Venkateswaran
authors.affiliation: Laboratório de Fitotecnologia , Departamento de Farmácia , Escola de Farmácia , Universidade Federal de Ouro Preto , Ouro Preto , Minas Gerais 35400-000 , Brazil.
authors.forename: Orlando David
authors.initials: OD
authors.lastname: Henrique Dos Santos
authors.affiliation: MRC Centre for Inflammation Research , The Queens Medical Research Institute , University of Edinburgh , 47 Little France Crescent , Edinburgh EH16 4TJ , UK.
authors.forename: Emma
authors.initials: E
authors.lastname: Scholefield
authors.affiliation: EaStCHEM School of Chemistry , University of Edinburgh , King's Buildings , West Mains Road , Edinburgh , EH9 3FJ , UK . Email: mark.bradley@ed.ac.uk.
authors.forename: Annamaria
authors.initials: A
authors.lastname: Lilienkampf
authors.affiliation: School of Biological Sciences , University of Edinburgh, King's Buildings , West Mains Road , Edinburgh , EH9 3JF , UK.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Gwynne
authors.affiliation: Critical Care , NHS Lothian , Royal Infirmary of Edinburgh , 51 Little France Crescent , Edinburgh , EH16 4SA , UK.
authors.forename: David G
authors.initials: DG
authors.lastname: Swann
authors.affiliation: MRC Centre for Inflammation Research , The Queens Medical Research Institute , University of Edinburgh , 47 Little France Crescent , Edinburgh EH16 4TJ , UK.
authors.forename: Kevin
authors.initials: K
authors.lastname: Dhaliwal
authors.affiliation: School of Biological Sciences , University of Edinburgh, King's Buildings , West Mains Road , Edinburgh , EH9 3JF , UK.
authors.forename: Maurice P
authors.initials: MP
authors.lastname: Gallagher
authors.affiliation: EaStCHEM School of Chemistry , University of Edinburgh , King's Buildings , West Mains Road , Edinburgh , EH9 3FJ , UK . Email: mark.bradley@ed.ac.uk.
authors.forename: Mark
authors.initials: M
authors.lastname: Bradley