title: Hepatitis B and Risk of Non-Hepatocellular Carcinoma Malignancy.
abstract: Chronic hepatitis B infection (CHB) is a known risk factor for malignancy. Unlike hepatocellular carcinoma (HCC), less is known about the risk of non-HCC malignancy. However, epidemiology and pathologic evidence suggests a strong association between non-Hodgkin lymphoma and CHB. Data regarding the risk of other malignancies, such as pancreatic adenocarcinoma and intrahepatic cholangiocarcinoma, are mixed. Surveillance and appropriate treatment of infection and malignancy in these patients is essential. Further study of these associations is needed and may bring new insights in the pathogenesis and treatment of these diseases.
authors.affiliation: Gastroenterology Fellowship Program, Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA. Electronic address: ryan.m.kwok.mil@mail.mil.
authors.forename: Ryan M
authors.initials: RM
authors.lastname: Kwok
authors.affiliation: Gastroenterology Fellowship Program, Cedars Sinai Medical Center, Geffen School of Medicine at University of California Los Angeles, 8900 Beverly Boulevard, Los Angeles, CA 90048, USA.
authors.forename: Tram T
authors.initials: TT
authors.lastname: Tran
mesh_terms: D001650:Bile Duct Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D063646:Carcinogenesis; D014943:Global Health; D006509:Hepatitis B / Q000150:complications*; D006801:Humans; D015994:Incidence; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D012307:Risk Factors
keywords: Chronic hepatitis B; Intrahepatic cholangiocarcinoma; Non-Hodgkin lymphoma; Non–hepatocellular carcinoma malignancy; Pancreatic adenocarcinoma