title: Flow Update for a Cossy Photocyclization.
abstract: A Cossy 5-exo-dig photocyclization of organohalides (X = Br, I) onto a C-C triple bond was studied using a flow photomicroreactor, which proceeded in a minute order of residence time. A deuterium labeling study supported the nonchain radical mechanism proposed by the Cossy group, in which a hydrogen source originates from a triethylamine cation radical. Scalable flow synthesis using a larger volume of flow reactor was also successful, providing 4 g of the product in high yield.
authors.affiliation: Department of Chemistry, Graduate School of Science, Osaka Prefecture University , Sakai, Osaka 599-8531, Japan.
authors.forename: Takahide
authors.initials: T
authors.lastname: Fukuyama
authors.affiliation: Department of Chemistry, Graduate School of Science, Osaka Prefecture University , Sakai, Osaka 599-8531, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Fujita
authors.affiliation: Department of Chemistry, Graduate School of Science, Osaka Prefecture University , Sakai, Osaka 599-8531, Japan.
authors.forename: Muhammad Abid
authors.initials: MA
authors.lastname: Rashid
authors.affiliation: Department of Chemistry, Graduate School of Science, Osaka Prefecture University , Sakai, Osaka 599-8531, Japan.
authors.forename: Ilhyong
authors.initials: I
authors.lastname: Ryu