title: Onco-GPCR signaling and dysregulated expression of microRNAs in human cancer.
abstract: The G-protein-coupled receptor (GPCR) family is the largest family of cell-surface receptors involved in signal transduction. Aberrant expression of GPCRs and G proteins are frequently associated with prevalent human diseases, including cancer. In fact, GPCRs represent the therapeutic targets of more than a quarter of the clinical drugs currently on the market. MiRNAs (miRNAs) are also aberrantly expressed in many human cancers, and they have significant roles in the initiation, development and metastasis of human malignancies. Recent studies have revealed that dysregulation of miRNAs and their target genes expression are associated with cancer progression. The emerging information suggests that miRNAs play an important role in the fine tuning of many signaling pathways, including GPCR signaling. We summarize our current knowledge of the individual functions of miRNAs regulated by GPCRs and GPCR signaling-associated molecules, and miRNAs that regulate the expression and activity of GPCRs, their endogenous ligands and their coupled heterotrimeric G proteins in human cancer.
authors.affiliation: Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA.
authors.forename: Nijiro
authors.initials: N
authors.lastname: Nohata
authors.affiliation: Department of Functional Genomics, Chiba University Graduate School of Medicine, Chiba, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Goto
authors.affiliation: Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA.|Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.
authors.forename: J Silvio
authors.initials: JS
authors.lastname: Gutkind
mesh_terms: D018450:Disease Progression; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics*
chemical_list: D035683:MicroRNAs; D043562:Receptors, G-Protein-Coupled; D020962:Heterotrimeric GTP-Binding Proteins