title: Fluorescent glycoprobes: a sweet addition for improved sensing.
abstract: The development of small-molecule fluorescent probes for the detection of ions and biomacromolecules and for cellular and in vivo imaging has been a very active research area. Nevertheless, many problems exist for traditional probes including their poor water solubility, toxicity and the inability to target specific tissues. Because of the enhanced water solubility, biocompatibility and targeting ability for specific cells, there has been an emerging movement to use carbohydrates as either the backbone or as a warhead to decorate conventional fluorescent probes, producing "glycoprobes" with enhanced properties. This feature article provides an overview of recently developed glycoprobes for ion and protein detection as well as targeted (receptor targeting) cellular imaging and theranostics. Here, we summarise the tactics for preparing small molecular glycoprobes and their supramolecular 2D material composites.
authors.affiliation: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, P. R. China. mrs_guorongchen@ecust.edu.cn.
authors.forename: Xiao-Peng
authors.initials: XP
authors.lastname: He
authors.affiliation: National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shoujing Rd., Shanghai 201203, P. R. China. jli@simm.ac.cn.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zang
authors.affiliation: Department of Chemistry, University of Bath, Bath, BA2 7AY, UK. t.d.james@bath.ac.uk.
authors.forename: Tony D
authors.identifier: 0000-0002-4095-2191
authors.initials: TD
authors.lastname: James
authors.affiliation: National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shoujing Rd., Shanghai 201203, P. R. China. jli@simm.ac.cn.
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.affiliation: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, P. R. China. mrs_guorongchen@ecust.edu.cn.
authors.forename: Guo-Rong
authors.initials: GR
authors.lastname: Chen
authors.affiliation: PPSM, ENS Cachan, CNRS UMR 8531, Université Paris-Saclay, 61 av President Wilson, F-94230 Cachan, France. joanne.xie@ppsm.ens-cachan.fr.
authors.forename: Juan
authors.initials: J
authors.lastname: Xie
mesh_terms: D002241:Carbohydrates / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000032:analysis / Q000737:chemistry*; D007477:Ions / Q000032:analysis; D057054:Molecular Imaging; D011506:Proteins / Q000032:analysis; D054852:Small Molecule Libraries / Q000032:analysis / Q000737:chemistry*; D012995:Solubility
chemical_list: D002241:Carbohydrates; D005456:Fluorescent Dyes; D007477:Ions; D011506:Proteins; D054852:Small Molecule Libraries