title: High risk of occult hepatitis B virus infection in leukemia patients from China.
abstract: In this study, we assessed the prevalence of overt and occult hepatitis B virus (HBV) infection among leukemia patients. Among 256 leukemia patients and 377 fracture patients (control group), we found that the hepatitis B surface-antigen-positive rate was greater in leukemia patients than in the controls (odds ratio, 2.08; p = 0.01). Moreover, the prevalence of occult HBV infection was higher in leukemia patients than in the controls (10.5 % vs. 2.9 %; odds ratio, 3.92; p < 0.001). The HBV genotype distribution differed significantly between the leukemia and chronic hepatitis B or control groups (p < 0.001 and 0.01, respectively); specifically, genotype C was primarily observed in occult HBV infection patients with leukemia. The stop codon mutation rate or amino acid substitutions in the major hydrophilic region did not differ between the groups. Thus, the prevalence of occult hepatitis B is higher in leukemia patients, and the HBV genotype distribution differs between patients with leukemia and chronic hepatitis B virus infection.
authors.affiliation: Department of Infectious Diseases, The First Affiliated Hospital, Anhui Medical University, Jixi Road 218, 230022, Hefei, China. zzh1974cn@163.com.|School of Pharmacy, Anhui Medical University, Hefei, 230022, China. zzh1974cn@163.com.
authors.forename: Zhenhua
authors.identifier: http://orcid.org/0000-0002-8480-9004
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Infectious Diseases, The First Affiliated Hospital, Anhui Medical University, Jixi Road 218, 230022, Hefei, China.
authors.forename: Yafei
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Infectious Diseases, The First Affiliated Hospital, Anhui Medical University, Jixi Road 218, 230022, Hefei, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Xu
authors.affiliation: School of Pharmacy, Anhui Medical University, Hefei, 230022, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Huang
authors.affiliation: Department of Infectious Diseases, The First Affiliated Hospital, Anhui Medical University, Jixi Road 218, 230022, Hefei, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Li
authors.affiliation: School of Pharmacy, Anhui Medical University, Hefei, 230022, China. lijun@ahmu.edu.cn.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D015870:Gene Expression; D005838:Genotype; D006510:Hepatitis B Antibodies / Q000096:biosynthesis; D006514:Hepatitis B Surface Antigens / Q000235:genetics* / Q000276:immunology; D006515:Hepatitis B virus / Q000235:genetics* / Q000254:growth & development / Q000472:pathogenicity; D019694:Hepatitis B, Chronic / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D006801:Humans; D007938:Leukemia / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D015995:Prevalence; D012306:Risk
chemical_list: D004279:DNA, Viral; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens