title: Multifunctional and Regenerable Antibacterial Surfaces Fabricated by a Universal Strategy.
abstract: Development of a versatile strategy for antibacterial surfaces is of great scientific interest and practical significance. However, few methods can be used to fabricate antibacterial surfaces on substrates of different chemistries and structures. In addition, traditional antibacterial surfaces may suffer problems related to the attached dead bacteria. Herein, antibacterial surfaces with multifunctionality and regenerability are fabricated by a universal strategy. Various substrates are first deposited with multilayered films containing guest moieties, which can be further used to incorporate biocidal host molecules, β-cyclodextrin (β-CD) derivatives modified with quaternary ammonium salt groups (CD-QAS). The resulting surfaces exhibit strong biocidal activity to kill more than 95% of attached pathogenic bacteria. Notably, almost all the dead bacteria can be easily removed from the surfaces by simple immersion in sodium dodecyl sulfate, and the regenerated surfaces can be treated with new CD-QAS for continued use. Moreover, when another functional β-CD derivative molecule is co-incorporated together with CD-QAS, the surfaces exhibit both functions simultaneously, and neither specific biofunction and antibacterial activity is compromised by the presence of the other. These results thus present a promising way to fabricate multifunctional and regenerable antibacterial surfaces on diverse materials and devices in the biomedical fields.
authors.affiliation: State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , 199 Ren'ai Road, Suzhou 215123, People's Republic of China.
authors.forename: Ting
authors.initials: T
authors.lastname: Wei
authors.affiliation: State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , 199 Ren'ai Road, Suzhou 215123, People's Republic of China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Zhan
authors.affiliation: State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , 199 Ren'ai Road, Suzhou 215123, People's Republic of China.
authors.forename: Limin
authors.initials: L
authors.lastname: Cao
authors.affiliation: State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , 199 Ren'ai Road, Suzhou 215123, People's Republic of China.
authors.forename: Changming
authors.initials: C
authors.lastname: Hu
authors.affiliation: State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , 199 Ren'ai Road, Suzhou 215123, People's Republic of China.
authors.forename: Yangcui
authors.initials: Y
authors.lastname: Qu
authors.affiliation: State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , 199 Ren'ai Road, Suzhou 215123, People's Republic of China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Yu
authors.affiliation: State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , 199 Ren'ai Road, Suzhou 215123, People's Republic of China.
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
keywords: antibacterial surface; host−guest interaction; layer-by-layer assembly; multifunctionality; regenerability