title: The NHR domains of Neuralized and related proteins: Beyond Notch signalling.
abstract: Neuralized Homology Repeats (NHRs) were first identified in Neuralized, an E3-ubiquitin ligase that plays a key role in the Notch signalling pathway. Since their original discovery, NHR domains have been shown to regulate protein-protein interactions in a broad range of developmental processes and in a wide variety of species from flies to humans. The NHR family of proteins can be categorized into three groups: (1) those that contain a RING finger, (2) those that contain a SOCS box and, (3) those that only have NHR domains. Here we review the structure and function of NHR domains in various cellular and developmental processes.
authors.affiliation: The Hospital for Sick Children, Program in Developmental and Stem Cell Biology, Peter Gilgan Center for Research and Learning, 686 Bay Street, Toronto, Ontario M5G1X8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
authors.forename: Sili
authors.initials: S
authors.lastname: Liu
authors.affiliation: The Hospital for Sick Children, Program in Developmental and Stem Cell Biology, Peter Gilgan Center for Research and Learning, 686 Bay Street, Toronto, Ontario M5G1X8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Electronic address: gboul@sickkids.ca.
authors.forename: Gabrielle L
authors.initials: GL
authors.lastname: Boulianne
mesh_terms: D000818:Animals; D006801:Humans; D009419:Nerve Tissue Proteins / Q000737:chemistry* / Q000378:metabolism*; D000072417:Protein Domains; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D009419:Nerve Tissue Proteins; D051880:Receptors, Notch
keywords: NEUZ domains; NHR; Neuralized; Notch; Protein adaptors; Signalling; Spry domains