title: Optimal vaccine schedules to maintain measles elimination with a two-dose routine policy.
abstract: Measles was eliminated in the Americas in 2002 by a combination of routine immunizations and supplementary immunization activities. Recent outbreaks underscore the importance of reconsidering vaccine policy in order to maintain elimination. We constructed an age-structured dynamical model for the distribution of immunity in a population with routine immunization and without disease, and analysed the steady state for an idealized age structure and for real age structures of countries in the Americas. We compared the level of immunity maintained by current policy in these countries to the level maintainable by an optimal policy. The optimal age target for the first routine dose of measles vaccine depends on the timing and coverage of both doses. Similarly, the optimal age target for the second dose of measles vaccine depends on the timing and coverage of the first dose. The age targets for the first and second doses of measles vaccine should be adjusted for the post-elimination era, by specifically accounting for current context, including realized coverage of both doses, and altered maternal immunity. Doing so can greatly improve the proportion immune within a population, and therefore the chances of maintaining measles elimination, without changing coverage.
authors.affiliation: Department of Biology, Pennsylvania State University, PA, USA.
authors.forename: A
authors.initials: A
authors.lastname: McKEE
authors.affiliation: Department of Biology, Pennsylvania State University, PA, USA.
authors.forename: K
authors.initials: K
authors.lastname: Shea
authors.affiliation: Department of Biology, Pennsylvania State University, PA, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Ferrari
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000569:Americas / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D060740:Disease Eradication; D005260:Female; D006291:Health Policy; D006801:Humans; D007115:Immunization Schedule; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008457:Measles / Q000517:prevention & control*; D008458:Measles Vaccine / Q000008:administration & dosage*; D008875:Middle Aged; D015233:Models, Statistical; D055815:Young Adult
chemical_list: D008458:Measles Vaccine
keywords: Maintenance of measles elimination; mathematical modelling; measles (rubeola); vaccination (immunization); vaccine policy development