title: The thalamo-cortical complex network correlates of chronic pain.
abstract: Chronic pain (CP) is a condition with a large repertory of clinical signs and symptoms with diverse expressions. Though widely analyzed, an appraisal at the level of single neuron and neuronal networks in CP is however missing. The present research proposes an empirical and theoretic framework which identifies a complex network correlate nested in the somatosensory thalamocortical (TC) circuit in diverse CP models. In vivo simultaneous extracellular neuronal electrophysiological high-density recordings have been performed from the TC circuit in rats. Wide functional network statistics neatly discriminated CP from control animals identifying collective dynamical traits. In particular, a collapsed functional connectivity and an altered modular architecture of the thalamocortical circuit have been evidenced. These results envisage CP as a functional connectivity disorder and give the clue for unveiling innovative therapeutic strategies.
authors.affiliation: Institute of Molecular Bioimaging and Physiology, Consiglio Nazionale delle Ricerche, Segrate (Milan), Italy.
authors.forename: Antonio G
authors.initials: AG
authors.lastname: Zippo
authors.affiliation: Institute of Molecular Bioimaging and Physiology, Consiglio Nazionale delle Ricerche, Segrate (Milan), Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Valente
authors.affiliation: Institute of Molecular Bioimaging and Physiology, Consiglio Nazionale delle Ricerche, Segrate (Milan), Italy.
authors.forename: Gian Carlo
authors.initials: GC
authors.lastname: Caramenti
authors.affiliation: Institute of Molecular Bioimaging and Physiology, Consiglio Nazionale delle Ricerche, Segrate (Milan), Italy.
authors.forename: Gabriele E M
authors.initials: GE
authors.lastname: Biella
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology*; D059350:Chronic Pain / Q000473:pathology / Q000503:physiopathology*; D063132:Connectome / Q000706:statistics & numerical data; D000069280:Electrocorticography; D008297:Male; D009415:Nerve Net / Q000473:pathology / Q000503:physiopathology*; D009474:Neurons / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013238:Stereotaxic Techniques; D013788:Thalamus / Q000473:pathology / Q000503:physiopathology*