title: Ubiquitous Importance of Protein Glycosylation.
abstract: More than half of all proteins are glycosylated. The attached glycans provide proteins with important structural and functional properties and glycan parts of glycoproteins have essential roles in many key biological processes. This chapter describes the effect of glycosylation on the structure and function of proteins, with emphasis on regulation of protein half-life and modulation of protein function by alternative glycosylation. In addition, this chapter highlights the importance of glycan-lectin interactions, the ability of glycans to block phosphorylation of proteins, and the importance of glycans in disease.
authors.affiliation: Genos Glycoscience Research Laboratory, Hondlova 2/11, Zagreb, Croatia.
authors.forename: Jasminka
authors.initials: J
authors.lastname: Krištić
authors.affiliation: Genos Glycoscience Research Laboratory, Hondlova 2/11, Zagreb, Croatia. glauc@pharma.hr.|Faculty of Pharmacy and Biochemistry, University of Zagreb, A. Kovačića 1, 10000, Zagreb, Croatia. glauc@pharma.hr.
authors.forename: Gordan
authors.initials: G
authors.lastname: Lauc
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002240:Carbohydrate Sequence; D006023:Glycoproteins / Q000737:chemistry / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D007074:Immunoglobulin G / Q000737:chemistry / Q000378:metabolism; D037102:Lectins / Q000737:chemistry / Q000378:metabolism; D010766:Phosphorylation; D011134:Polysaccharides / Q000032:analysis* / Q000378:metabolism; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism
chemical_list: D006023:Glycoproteins; D007074:Immunoglobulin G; D037102:Lectins; D011134:Polysaccharides; D011506:Proteins
keywords: Alternative glycosylation; Glycans; Glycosylation in disease; IgG glycosylation; Lectins; O-GlcNAc; Protein function; Protein half-life; Protein structure