title: Advances in understanding the pathogenesis of CNS acute lymphoblastic leukaemia and potential for therapy.
abstract: Central nervous system acute lymphoblastic leukaemia (CNS-ALL) is a major clinical problem. CNS-directed 'prophylactic' chemo- or radio - therapy is associated with significant early and long-term toxicity. Moreover, greater than a third of the relapses occur in the CNS. To design specific, more effective and less toxic therapy and for personalized precise adjustment of prophylactic therapy there is a need for better understanding of the biology of this disease. Specifically, the precise neurotropic mechanisms of ALL are currently unclear, as is the pathogenesis of CNS relapse. Here we review and contrast the recent findings with earlier studies of pathogenesis of CNS leukaemia. We also describe the challenges in research of this devastating complication of ALL.
authors.affiliation: Childhood Leukaemia Research Section, Department of Paediatric Oncology and the Cancer Research Centre, Safra Children Hospital and Sheba Medical Centre, Tel Hashomer, Ramat Gan, Israel.|Department of Human Genetics and Biochemistry, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Liron
authors.initials: L
authors.lastname: Frishman-Levy
authors.affiliation: Childhood Leukaemia Research Section, Department of Paediatric Oncology and the Cancer Research Centre, Safra Children Hospital and Sheba Medical Centre, Tel Hashomer, Ramat Gan, Israel.|Department of Human Genetics and Biochemistry, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Shai
authors.initials: S
authors.lastname: Izraeli
mesh_terms: D016543:Central Nervous System Neoplasms / Q000473:pathology / Q000628:therapy*; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000473:pathology / Q000628:therapy*
keywords: acute lymphoblastic leukaemia; central nervous system