title: Cardiac Manifestations of Congenital Generalized Lipodystrophy.
abstract: IN BRIEFCongenital lipodystrophy is a rare genetic disorder characterized by a near-complete absence of fat cells, hypoleptinemia leading to a voracious appetite, and marked insulin resistance. This article focuses on the known cardiovascular manifestations of patients with congenital lipodystrophy, including cardiomyopathy, cardiac arrhythmias, and accelerated atherosclerosis arising from a markedly deranged metabolic milieu. Future research that targets leptin deficiency (metreleptin) and apoC3 mRNA (antisense oligonucleotide) could open a window for potential pharmacological treatment of this challenging disorder.
authors.affiliation: Division of Cardiology, University of Texas Health Science Center at San Antonio and Audie L. Murphy VA Hospital, San Antonio, TX.
authors.forename: Vani P
authors.initials: VP
authors.lastname: Sanon
authors.affiliation: Metabolic Institute of America, Tarzana, CA.
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Handelsman
authors.affiliation: Division of Cardiology, University of Texas Health Science Center at San Antonio and Audie L. Murphy VA Hospital, San Antonio, TX.
authors.forename: Son V
authors.initials: SV
authors.lastname: Pham
authors.affiliation: Division of Cardiology, University of Texas Health Science Center at San Antonio and Audie L. Murphy VA Hospital, San Antonio, TX.
authors.forename: Robert
authors.initials: R
authors.lastname: Chilton