title: Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment.
abstract: Nowadays bacterial resistance to known antibiotics is a serious health problem. In order to achieve more efficient treatment, lately there is an effort to find new substances, such as certain biomaterials, that are non-toxic to humans with antibiotic potential. Lignins and lignin-derived compounds have been proposed to be good candidates for use in medicine and health maintenance. In this study, the antibacterial activity of the lignin model polymer dehydrogenate polymer (DHP) in alginate hydrogel (Alg) was studied. The obtained results show that DHP-Alg has strong antimicrobial activity against several bacterial strains and biofilms and does not have a toxic effect on human epithelial cells. These results strongly suggest its application as a wound healing agent or as an adjunct substance for wound treatments.
authors.affiliation: Institute for Multidisciplinary Research, University of Belgrade, Kneza Višeslava 1, 11000 Belgrade, Serbia.
authors.forename: Dragica
authors.initials: D
authors.lastname: Spasojević
authors.affiliation: Vinča Institute of Nuclear Sciences, University of Belgrade, Mihaila Petrovića Alasa 12-14, 11000 Belgrade, Serbia.
authors.forename: Danica
authors.initials: D
authors.lastname: Zmejkoski
authors.affiliation: University of Belgrade, Mycological Laboratory, Department of Plant Physiology, Institute for Biological Research 'Siniša Stanković', Bulevar Despota Stefana 142, 11000 Belgrade, Serbia.
authors.forename: Jasmina
authors.initials: J
authors.lastname: Glamočlija
authors.affiliation: University of Belgrade, Mycological Laboratory, Department of Plant Physiology, Institute for Biological Research 'Siniša Stanković', Bulevar Despota Stefana 142, 11000 Belgrade, Serbia.
authors.forename: Miloš
authors.initials: M
authors.lastname: Nikolić
authors.affiliation: University of Belgrade, Mycological Laboratory, Department of Plant Physiology, Institute for Biological Research 'Siniša Stanković', Bulevar Despota Stefana 142, 11000 Belgrade, Serbia.
authors.forename: Marina
authors.initials: M
authors.lastname: Soković
authors.affiliation: Department of Cytology, Institute for Biological Research 'Siniša Stanković', University of Belgrade, Belgrade, Serbia.
authors.forename: Verica
authors.initials: V
authors.lastname: Milošević
authors.affiliation: Department of Cytology, Institute for Biological Research 'Siniša Stanković', University of Belgrade, Belgrade, Serbia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Jarić
authors.affiliation: Department for Research & Development, Institute for Virology, Vaccines and Sera 'Torlak', Vojvode Stepe 458, 11152 Belgrade, Serbia.
authors.forename: Marijana
authors.initials: M
authors.lastname: Stojanović
authors.affiliation: Department for Research & Development, Institute for Virology, Vaccines and Sera 'Torlak', Vojvode Stepe 458, 11152 Belgrade, Serbia.
authors.forename: Emilija
authors.initials: E
authors.lastname: Marinković
authors.affiliation: OCUVAC-Centre of Ocular Inflammation and Infection, Laura Bassi Centre of Expertise, Institute of Specific Prophylaxis and Tropical Medicine, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, Sensengasse 2a, A-1090 Vienna, Austria.
authors.forename: Talin
authors.initials: T
authors.lastname: Barisani-Asenbauer
authors.affiliation: Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia.
authors.forename: Radivoje
authors.initials: R
authors.lastname: Prodanović
authors.affiliation: Institute of Physiology and Biochemistry, Faculty of Biology, University of Belgrade, Studentski trg 3, 11000 Belgrade, Serbia.
authors.forename: Miloš
authors.initials: M
authors.lastname: Jovanović
authors.affiliation: Institute for Multidisciplinary Research, University of Belgrade, Kneza Višeslava 1, 11000 Belgrade, Serbia. Electronic address: xenia@imsi.rs.
authors.forename: Ksenija
authors.initials: K
authors.lastname: Radotić
mesh_terms: D000464:Alginates; D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000633:toxicity; D001419:Bacteria / Q000187:drug effects*; D001672:Biocompatible Materials; D018441:Biofilms / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers; D004847:Epithelial Cells / Q000187:drug effects / Q000502:physiology; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D008031:Lignin / Q000494:pharmacology* / Q000633:toxicity; D008826:Microbial Sensitivity Tests; D014947:Wounds and Injuries / Q000188:drug therapy
chemical_list: D000464:Alginates; D000890:Anti-Infective Agents; D001672:Biocompatible Materials; D004337:Drug Carriers; D006603:Hexuronic Acids; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D020723:Glucuronic Acid; D008031:Lignin
keywords: Alginate; Antimicrobial activity; Bacterial biofilm; Lignin model polymer; Wound treatment