title: Association betweenAPOEGenotype and Change in Physical Function in a Population-Based Swedish Cohort of Older Individuals Followed Over Four Years.
abstract: The association between decline in physical function and age-related conditions, such as reduced cognitive performance and vascular disease, may be explained by genetic influence on shared biological pathways of importance for aging. The apolipoprotein E (APOE) gene is well-known for its association with Alzheimer's disease, but has also been related to other disorders of importance for aging. The aim of this study was to investigate possible associations betweenAPOEallele status and physical function in a population-based longitudinal study of older individuals. In 2005, at the age of 75, 622 individuals underwent neuropsychiatric and physical examinations, including tests of physical function, andAPOE-genotyping. Follow-up examinations were performed at age 79. A significantly larger decline in grip strength (p= 0.015) between age 75 and 79 was found when comparingAPOE𝜀4 allele carriers with non-carriers [10.3 (±10.8) kg versus 7.8 (±10.1) kg]. No association was seen with decline in gait speed, chair-stand, or balance. The association with grip strength remained after correction for cognitive and educational level, depression, cardiovascular disease, stroke, and BMI.
authors.affiliation: Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg Mölndal, Sweden.
authors.forename: Ingmar
authors.initials: I
authors.lastname: Skoog
authors.affiliation: Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg Mölndal, Sweden.
authors.forename: Helena
authors.initials: H
authors.lastname: Hörder
authors.affiliation: Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg Mölndal, Sweden.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Frändin
authors.affiliation: Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg Mölndal, Sweden.
authors.forename: Lena
authors.initials: L
authors.lastname: Johansson
authors.affiliation: Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg Mölndal, Sweden.
authors.forename: Svante
authors.initials: S
authors.lastname: Östling
authors.affiliation: Clinical Neurochemistry Lab, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, at the University of Gothenburg Mölndal, Sweden.
authors.forename: Kaj
authors.initials: K
authors.lastname: Blennow
authors.affiliation: Clinical Neurochemistry Lab, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, at the University of GothenburgMölndal, Sweden; Department of Molecular Neuroscience, Institute of Neurology, University College of LondonLondon, UK.
authors.forename: Henrik
authors.initials: H
authors.lastname: Zetterberg
authors.affiliation: Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg Mölndal, Sweden.
authors.forename: Anna
authors.initials: A
authors.lastname: Zettergren
keywords: APOE 𝜀4 allele; dementia; gait speed; grip strength; physical function