title: Adult onset Still's disease with dermatopathic lymphadenopathy.
abstract: Adult onset Still's disease (AOSD) is a chronic inflammatory disorder involving multiple systems. The symptoms mimic those of lymphomas, therefore, the diagnosis of lymphoma needs to be excluded prior to establishing the diagnosis of AOSD. Another similar condition is dermatopathic lymphadenopathy (DL). In DL, the histopathological appearance of lymph node biopsy may also mimic AOSD. The DL is associated with several systemic pathologies, such as malignant lymphomas, and rarely AOSD. We present a case of a 43-year-old male presented with 3 months history of fatigue, fever, and lymphadenopathy. Initial work-up satisfactorily met the criteria for diagnosis of AOSD. But considering the well-known association of DL with hematological malignancies, detailed pathological studies were considered, including tumor markers to rule out  the possibility of malignancy. The patient was started on steroids and showed remarkable recovery within 2 weeks. Evaluation of malignant lymphomas in a patient with DL is important, in order to diagnose AOSD and rule out hematological malignancy.
authors.affiliation: Department of Physical Medicine and Rehabilitation, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia. E-mail. qureshipmr@gmail.com.
authors.forename: Ahmad Z
authors.initials: AZ
authors.lastname: Qureshi
authors.forename: Mohammad
authors.initials: M
authors.lastname: AlSheef
authors.forename: Waqas T
authors.initials: WT
authors.lastname: Qureshi
authors.forename: Waseem
authors.initials: W
authors.lastname: Amjad
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D000072281:Lymphadenopathy; D008206:Lymphatic Diseases / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D016706:Still's Disease, Adult-Onset / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids