title: Oxidative damage of the male reproductive system induced by paraquat.
abstract: The effects of paraquat (PQ) on the male reproductive system are unclear. In this study, male rats were divided into four groups (0, 0.5, 2, and 8 mg/kg) and treated with PQ by oral gavage for 8 weeks. At the end of the experiment, a significant decline in sperm count, motility, and viability and an increase in teratospermia were observed in the PQ-treated group (P < 0.05). Further investigation found that PQ resulted in enhanced lipid peroxidation and more apoptosis in the testis tissues, and apoptosis was likely to be associated with activation of the mitochondrial pathway. In summary, our study demonstrated oxidative damage due to PQ on the male reproductive system.
authors.affiliation: Department of Gynecology and Obstetrics, the Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, the People's Republic of China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Gynecology and Obstetrics, the Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, the People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Gynecology and Obstetrics, the Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, the People's Republic of China.
authors.forename: Jin-Yan
authors.initials: JY
authors.lastname: Zhao
authors.affiliation: Department of Gynecology and Obstetrics, the Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, the People's Republic of China.
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Lu
authors.affiliation: Department of Reproductive Medicine, the First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, the People's Republic of China.
authors.forename: Peng-Sheng
authors.initials: PS
authors.lastname: Zheng
authors.affiliation: Department of Gynecology and Obstetrics, the Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, the People's Republic of China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Xue
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D006540:Herbicides / Q000633:toxicity; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects*; D010269:Paraquat / Q000633:toxicity*; D051381:Rats; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects*; D000072660:Teratozoospermia / Q000139:chemically induced / Q000503:physiopathology*
chemical_list: D006540:Herbicides; D010269:Paraquat
keywords: Paraquat; mitochondrial pathway; oxidative damage; reproductive system