title: Facile fabrication of robust polydopamine microcapsules for insulin delivery.
abstract: Inspired by the composition of adhesive proteins in mussel, a facile, low-cost, and green approach to construct robust polydopamine (PDA) microcapsules as carriers for insulin delivery is developed. The morphology and shell thickness of the capsules could be tuned by varying the concentration of dopamine or the pH of Tris-HCl buffer. The PDA capsules are stable enough for long-term storage and transportation in practical application. The fluorescent property of PDA capsules labeled with FITC is beneficial in monitoring the safety and efficacy of drug carriers. Furthermore, the PDA shell coated insulin particles exhibit pH-responsive release behavior, making them promising for the oral administration of insulin in diabetic patients.
authors.affiliation: School of Chemistry and Chemical Engineering, Xi'an Shiyou University, Xi'an 710065, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.affiliation: Beijing National Laboratory for Molecular Sciences, CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Jia
authors.affiliation: Beijing National Laboratory for Molecular Sciences, CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Xiyun
authors.initials: X
authors.lastname: Feng
authors.affiliation: Beijing National Laboratory for Molecular Sciences, CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. Electronic address: jbli@iccas.ac.cn.
authors.forename: Junbai
authors.initials: J
authors.lastname: Li
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000138:chemical synthesis*; D049872:Bivalvia / Q000737:chemistry; D002021:Buffers; D002214:Capsules / Q000138:chemical synthesis*; D004337:Drug Carriers; D004339:Drug Compounding; D065546:Drug Liberation; D016650:Fluorescein-5-isothiocyanate; D005456:Fluorescent Dyes; D055772:Green Chemistry Technology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007211:Indoles / Q000138:chemical synthesis*; D007328:Insulin / Q000737:chemistry*; D007700:Kinetics; D011108:Polymers / Q000138:chemical synthesis*
chemical_list: D002021:Buffers; D002214:Capsules; D004337:Drug Carriers; D005456:Fluorescent Dyes; D007211:Indoles; D007328:Insulin; D011108:Polymers; C568283:polydopamine; D016650:Fluorescein-5-isothiocyanate
keywords: Insulin; Oxidative self-polymerization; Polydopamine microcapsules; pH-responsive release