title: Nodular granulomatous glossitis as the sole clinical sign in canine leishmaniosis.
abstract: A 5.5-year-old, intact male Rottweiler dog was admitted with a history of multifocal nodular tongue lesions which progressively deteriorated during the previous year. Physical examination revealed several reddish nodules with central depression on the surface of the tongue in an otherwise healthy dog. Clinicopathologic abnormalities included eosinophilia and hyperproteinemia. Lingual nodule cytopathology, histopathology, and immunohistochemistry revealed Leishmania spp. amastigotes and a severe granulomatous glossitis. The dog was also seroreactive to L infantum antigens by an indirect immunofluorescence assay. Clinical reevaluation 3 months after the institution of treatment with allopurinol and miltefosine indicated that the nodular lesions had completely regressed. In endemic areas, lingual nodular lesions may rarely be the sole clinical sign of canine leishmaniosis. Standard medical treatment may provide an excellent prognosis.
authors.affiliation: Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Melpomeni K
authors.initials: MK
authors.lastname: Tangalidi
authors.affiliation: Diagnostic Laboratory, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Ioannis L
authors.initials: IL
authors.lastname: Oikonomidis
authors.affiliation: Laboratory of Pathology, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Dimitra
authors.initials: D
authors.lastname: Psalla
authors.affiliation: Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Serafim
authors.initials: S
authors.lastname: Papadimitriou
authors.affiliation: Diagnostic Laboratory, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Kritsepi-Konstantinou
authors.affiliation: Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Mathios E
authors.initials: ME
authors.lastname: Mylonakis
mesh_terms: D000493:Allopurinol / Q000627:therapeutic use; D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D004283:Dog Diseases / Q000175:diagnosis* / Q000469:parasitology / Q000473:pathology; D004285:Dogs; D004359:Drug Therapy, Combination; D019084:Fluorescent Antibody Technique, Indirect; D005928:Glossitis / Q000175:diagnosis / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry / Q000662:veterinary; D018314:Leishmania infantum / Q000276:immunology / Q000302:isolation & purification*; D007898:Leishmaniasis, Visceral / Q000175:diagnosis / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D008297:Male; D010767:Phosphorylcholine / Q000031:analogs & derivatives / Q000627:therapeutic use; D014059:Tongue / Q000469:parasitology / Q000473:pathology
chemical_list: D000981:Antiprotozoal Agents; D010767:Phosphorylcholine; C039128:miltefosine; D000493:Allopurinol
keywords: 
  Leishmania infantum
  ; Amastigotes; cytology; dog; immunohistochemistry; lingual nodules