title: Large Scale Production of Continuous Hydrogel Fibers with Anisotropic Swelling Behavior by Dynamic-Crosslinking-Spinning.
abstract: Hydrogel microfibers have been considered as a potential biomaterial to spatiotemporally biomimic 1D native tissues such as nerves and muscles which are always assembled hierarchically and have anisotropic response to external stimuli. To produce facile hydrogel microfibers in a mathematical manner, a novel dynamic-crosslinking-spinning (DCS) method is demonstrated for direct fabrication of size-controllable fibers from poly(ethylene glycol diacrylate) oligomer in large scale, without microfluidic template and in a biofriendly environment. The diameter of fibers can be precisely controlled by adjusting the spinning parameters. Anisotropic swelling property is also dependent on inhomogeneous structure generated in spinning process. Comparing with bulk hydrogels, the resulting fibers exhibit superior rapid water adsorption property, which can be attributed to the large surface area/volume ratio of fiber. This novel DCS method is one-step technology suitable for large-scale production of anisotropic hydrogel fibers which has a promising application in the area such as biomaterials.
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai, 201620, P. R. China.
authors.forename: Kai
authors.initials: K
authors.lastname: Hou
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai, 201620, P. R. China.
authors.forename: Huiyi
authors.initials: H
authors.lastname: Wang
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai, 201620, P. R. China.
authors.forename: Yunyin
authors.initials: Y
authors.lastname: Lin
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai, 201620, P. R. China.
authors.forename: Shaohua
authors.initials: S
authors.lastname: Chen
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai, 201620, P. R. China.
authors.forename: Shengyuan
authors.initials: S
authors.lastname: Yang
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai, 201620, P. R. China.
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Department of Chemistry, Stony Brook University, Stony Brook, NY, 11794, USA.
authors.forename: Benjamin S
authors.initials: BS
authors.lastname: Hsiao
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai, 201620, P. R. China.
authors.forename: Meifang
authors.initials: M
authors.lastname: Zhu
keywords: anisotropic swelling; biomaterials; hydrogel; hydrogel fibers; rapid swelling