title: Prenatal compensatory renal growth in unilateral renal agenesis.
abstract: OBJECTIVE
  To create nomograms of fetal renal compensatory growth in cases of unilateral renal agenesis (URA).
  
  
  METHODS
  A retrospective study of fetuses with isolated URA diagnosed prenatally, and confirmed postnatal was performed.
  
  
  RESULTS
  Seventy-four fetuses with isolated solitary kidney were included in the study. A total of 134 measurements of the kidney's length were performed. Ninety five of them were studied longitudinally (2-6 measurements each). The raw values of the compensatory kidney demonstrated a significant correlation with gestational age (Pearson correlation coefficient 0.901, p < 0.001). A quadratic/cubic regression curve, both, described best this relationship, -26.400 + 3.004*GA, -0.026*GA2(r2= 0.819). The Z score between the mean predicted compensatory kidney's length, per week of gestation, and the mean predicted values of normal kidney length as previously published in the literature, progressively increased during pregnancy (cubic r2= 0.946 and 0.260).
  
  
  CONCLUSIONS
  Cases of URA show a unique growth pattern of the single kidney from second trimester to term. Postnatal renal function is dependent on adequate intra-uterine compensatory growth; the presented nomograms provide insight into renal prognosis and add paramount information to the multidisciplinary prenatal counseling of the future parents. © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Prenatal Diagnostic Unit, Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Israel.|Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Sharon
authors.initials: S
authors.lastname: Perlman
authors.affiliation: Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.|Division of Pediatric Nephrology, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: Dani
authors.initials: D
authors.lastname: Lotan
authors.affiliation: Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.|Division of Pediatric Nephrology, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel-Hashomer, Israel.|Pediatric Stem Cell Research Institute, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Dekel
authors.affiliation: Prenatal Diagnostic Unit, Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Israel.|Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Zvi
authors.initials: Z
authors.lastname: Kivilevitch
authors.affiliation: Ultrasound Unit, Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot, Israel.|Hadassah School of Medicine, Hebrew University, Jerusalem, Israel.
authors.forename: Yinon
authors.initials: Y
authors.lastname: Hazan
authors.affiliation: Prenatal Diagnostic Unit, Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Israel.|Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Reuven
authors.initials: R
authors.lastname: Achiron
authors.affiliation: Prenatal Diagnostic Unit, Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Israel.|Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Yinon
authors.initials: Y
authors.lastname: Gilboa
mesh_terms: D000013:Congenital Abnormalities; D005260:Female; D047109:Fetal Development; D006801:Humans; D007668:Kidney / Q000002:abnormalities* / Q000196:embryology*; D007674:Kidney Diseases / Q000151:congenital*; D049451:Nomograms; D011247:Pregnancy; D012189:Retrospective Studies