title: [Association between body mass index and its change and type 2 diabetes mellitus risk in a prospective study].
abstract: Objective:To investigate the influence of body mass index (BMI) and its change on the incidence of type 2 diabetes mellitus (T2DM) in an adult cohort.Methods:A total of 3 043 subjects randomly selected among those without T2DM at baseline survey from the Rural Deqing Health Cohort Study were included into this study and follow up was conducted for 1 867 of them from July to November 2015. The subjects were divided into 3 groups according to their baseline BMI, normal group (BMI<24.0), overweight group (BMI: 24.0-27.9) and obese group (BMI≥28.0) and the subjects with stable weight (BMI change of-0.05 to + 0.05 per year) were used as the referent category. Cox proportional model was used to estimate associations between BMI, its changes and T2DM.Results:With an average of (8.68±1.25) person years, 213 new T2DM cases, including 125 females were detected, and incidence density was 13.14 per 1 000 person years. After adjusted for other covariates, the risk for incidence of T2DM was significantly higher in subjects with baseline BMI≥28.0 kg/m2than those with baseline BMI<24.0 kg/m2(aHR=2.12, 95% CI: 1.22-3.68), and weight gains were strongly associated with the incidence of T2DM in those with baseline BMI< 24.0 kg/m2(aHR=2.21, 95%CI:1.17-4.17).Conclusion:Both BMI and its change were significantly associated with incidence of T2DM, especially in the population with BMI<24.0 kg/m2at baseline.
authors.affiliation: School of Public Health and Key Laboratory of Public Health Safety, Fudan University, Shanghai 200032, China.
authors.forename: X Y
authors.initials: XY
authors.lastname: Chen
authors.affiliation: School of Public Health and Key Laboratory of Public Health Safety, Fudan University, Shanghai 200032, China.
authors.forename: Z F
authors.initials: ZF
authors.lastname: Wu
authors.affiliation: Deqing County Center for Disease Prevention and Control, Huzhou 313200, China.
authors.forename: X C
authors.initials: XC
authors.lastname: Wang
authors.affiliation: Deqing County Center for Disease Prevention and Control, Huzhou 313200, China.
authors.forename: X L
authors.initials: XL
authors.lastname: Dong
authors.affiliation: Deqing County Center for Disease Prevention and Control, Huzhou 313200, China.
authors.forename: J F
authors.initials: JF
authors.lastname: Zhu
authors.affiliation: Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1N6N5, Canada.
authors.forename: T
authors.initials: T
authors.lastname: Chen
authors.affiliation: School of Public Health and Key Laboratory of Public Health Safety, Fudan University, Shanghai 200032, China.
authors.forename: Q W
authors.initials: QW
authors.lastname: Xiao
authors.affiliation: School of Public Health and Key Laboratory of Public Health Safety, Fudan University, Shanghai 200032, China.
authors.forename: Z W
authors.initials: ZW
authors.lastname: Jiang
authors.affiliation: School of Public Health and Key Laboratory of Public Health Safety, Fudan University, Shanghai 200032, China.
authors.forename: Chaowei
authors.initials: C
authors.lastname: Fu
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002681:China / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009765:Obesity; D050177:Overweight; D011446:Prospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires; D015430:Weight Gain