title: Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa.
abstract: Four new clerodane diterpenoids, tinosporols A-C (2-4) and tinosporoside A (5), together with six known analogues were isolated from the vines of Tinospora crispa. Their structures were established by extensive spectroscopic analysis. The relative configuration at C-12 in the known diterpenoid borapetoside E (1), the major component of the plant, was firstly established with the aid of molecular model. Compound 1 significantly reduced serum glucose levels at dose-dependent manners in alloxan-induced hyperglycemic mice and db/db type 2 diabetic mice.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, People's Republic of China.|Department of Chemical Engineering, Yibin University, Yibin, 644000, People's Republic of China.|BioBioPha Co., Ltd, Kunming, 650201, People's Republic of China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Gao
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, People's Republic of China.|Graduate University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.|Yunnan University, Kunming, 650091, People's Republic of China.
authors.forename: Yan-Fen
authors.initials: YF
authors.lastname: Niu
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, People's Republic of China.|BioBioPha Co., Ltd, Kunming, 650201, People's Republic of China.
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Chemical Engineering, Yibin University, Yibin, 644000, People's Republic of China.|BioBioPha Co., Ltd, Kunming, 650201, People's Republic of China.
authors.forename: Ping
authors.initials: P
authors.lastname: Hai
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, People's Republic of China.|Graduate University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.affiliation: BioBioPha Co., Ltd, Kunming, 650201, People's Republic of China.
authors.forename: Yin-Dong
authors.initials: YD
authors.lastname: Fang
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, People's Republic of China. xiong.wenyong@mail.kib.ac.cn.
authors.forename: Wen-Yong
authors.initials: WY
authors.lastname: Xiong
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, People's Republic of China. jkliu@mail.kib.ac.cn.|School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, 430074, China. jkliu@mail.kib.ac.cn.
authors.forename: Ji-Kai
authors.initials: JK
authors.lastname: Liu
keywords: Anti-hyperglycemia