title: Isolated left ventricular arrhythmogenic cardiomyopathy: A case report.
abstract: Left ventricular involvement in the advanced stage of arrhythmogenic cardiomyopathy (AC) is an evolution of this desmosomopathy. Mutation in intercalated discs explains the phenotypic variability. Abnormal trafficking of the intercalated discs at the site of end-to-end contacts between cardiomyocytes and the canonical Wnt/β-catenin and Hippo signaling pathways have been implicated. In AC, T-wave inversion in lateral leads is the hallmark of left ventricular (LV) involvement. We herein report a case of isolated LV AC in which the initial ECG has typical features: fragmented QRS (fQRS), Twave inversion (TWI) in lateral leads, and ventricular tachycardia from inferobasal LV wall.
authors.affiliation: Coronary Center of the Hospital de Messejana Dr. Carlos Alberto Studart Gomes, Fortaleza, CE, Brazil.
authors.forename: Raimundo
authors.initials: R
authors.lastname: Barbosa-Barros
authors.affiliation: Design of Studies and Scientific Writing Laboratory at the ABC School of Medicine, Santo André, São Paulo, Brazil. Electronic address: riera@uol.com.br.
authors.forename: Andrés Ricardo
authors.initials: AR
authors.lastname: Pérez-Riera
authors.affiliation: Design of Studies and Scientific Writing Laboratory at the ABC School of Medicine, Santo André, São Paulo, Brazil.
authors.forename: Luiz Carlos
authors.initials: LC
authors.lastname: de Abreu
authors.affiliation: Coronary Center of the Hospital de Messejana Dr. Carlos Alberto Studart Gomes, Fortaleza, CE, Brazil.
authors.forename: Ricardo Paulo
authors.initials: RP
authors.lastname: de Sousa-Rocha
authors.affiliation: Coronary Center of the Hospital de Messejana Dr. Carlos Alberto Studart Gomes, Fortaleza, CE, Brazil.
authors.forename: Danielli
authors.initials: D
authors.lastname: Oliveira da Costa Lino
authors.affiliation: Division of Cardiology, Queen's University, Kingston, Ontario, Canada.
authors.forename: Adrian
authors.initials: A
authors.lastname: Baranchuk
authors.affiliation: Lankenau Medical Center and Lankenau Institute for Medical Research, Wynnewood, PA, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
mesh_terms: D009202:Cardiomyopathies / Q000150:complications* / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004562:Electrocardiography / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017180:Tachycardia, Ventricular / Q000150:complications* / Q000175:diagnosis*; D018487:Ventricular Dysfunction, Left / Q000150:complications* / Q000175:diagnosis*
keywords: Electrocardiogram; Intercalated disc; Isolated left ventricular arrhythmogenic cardiomyopathy