title: Cause of cancer and chronic inflammatory diseases and the implications for treatment.
abstract: Many pathogens exist in metabolically inactive, non-culturable, cell-wall-deficient (CWD) forms that allow them to survive in conditions not conducive for growth. These forms were found in both cancer and chronic inflammatory autoimmune diseases. This review presents several novel concepts about how chronic inflammatory response and cancer develops from CWD infection, involvement and role of the immune system and other 'omics' systems and how to better diagnose, treat and even cure these conditions. This concept shows that CWD forms of intracellular microbes could also be evolutionary advantageous spreading through the host without using the classical replication route.
authors.affiliation: NIBRT GlycoScience Group, The National Institute for Bioprocessing Research and Training, Fosters Ave., Mount Merrion, Blackrock, Dublin 4, Ireland.
authors.forename: Radka
authors.initials: R
authors.lastname: Saldova
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000209:etiology*; D015551:Autoimmunity; D001419:Bacteria / Q000187:drug effects / Q000378:metabolism / Q000472:pathogenicity*; D002473:Cell Wall / Q000187:drug effects; D002908:Chronic Disease; D004734:Energy Metabolism; D044127:Epigenesis, Genetic; D020022:Genetic Predisposition to Disease; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D007167:Immunotherapy; D007249:Inflammation / Q000188:drug therapy / Q000209:etiology*; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy / Q000209:etiology*
chemical_list: D000900:Anti-Bacterial Agents