title: Supplementation of a Fermented Soybean Extract Reduces Body Mass and Prevents Obesity in High Fat Diet-Induced C57BL/6J Obese Mice.
abstract: Obesity is a growing health problem that many countries face, mostly due to the consumption of a Westernized diet. In this present study we observed the effects of a soybean extract fermented byBacillus subtilisMORI (BTD-1) containing 1-deoxynojirimycin against high fat diet-induced obesity. The results obtained from this study indicated that BTD-1 reduced body weight, regulated hepatic lipid content and adipose tissue, and also affected liver antioxidant enzymes and glucose metabolism. These results suggest that administration of BTD-1 affects obesity by inhibiting hyperglycemia and free radical-mediated stress; it also reduces lipid accumulation. Therefore, BTD-1 may be potentially useful for the prevention of obesity and its related secondary complications.
authors.affiliation: R&D Center for Life Science, Biotopia Co., Ltd., Gangwon 24398, Korea.
authors.forename: Jae Yeon
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Department of Physiology, College of Veterinary Medicine, Chonbuk National University, Jeonbuk 54596, Korea.
authors.forename: Adithan
authors.initials: A
authors.lastname: Aravinthan
authors.affiliation: R&D Center for Life Science, Biotopia Co., Ltd., Gangwon 24398, Korea.
authors.forename: Young Shik
authors.initials: YS
authors.lastname: Park
authors.affiliation: R&D Center for Life Science, Biotopia Co., Ltd., Gangwon 24398, Korea.
authors.forename: Kyo Yeol
authors.initials: KY
authors.lastname: Hwang
authors.affiliation: R&D Center for Life Science, Biotopia Co., Ltd., Gangwon 24398, Korea.
authors.forename: Su-Il
authors.initials: SI
authors.lastname: Seong
authors.affiliation: Department of Food and Nutrition, Nambu University, Gwangju 62271, Korea.
authors.forename: Kwontack
authors.initials: K
authors.lastname: Hwang
keywords: antioxidant enzymes; fermented soybean extracts; glucose metabolism; lipid accumulation; obesity