title: Whole blood and hair trace elements and minerals in children living in metal-polluted area near copper smelter in Karabash, Chelyabinsk region, Russia.
abstract: The primary aim of the study is assessment of hair and whole blood trace element and mineral levels in children living in a polluted area near a copper smelter (Karabash) and two control locations (Varna, Tomino) using inductively coupled plasma mass spectrometry. The obtained data indicates that both blood and hair As, Pb, and Fe levels in children living in Karabash significantly exceeded the control values. Whole blood levels of copper in children living in Varna exceeded that in Tomino (p = 0.155) and Karabash (p < 0.001) by 16 %. Oppositely, hair concentration of Cu was maximal in children from Karabash. Blood Ca and Mg content in children from Varna exceeded the respective values from Tomino and Karabash by 32 % (p = 0.021) and 42 % (p < 0.001), and 19 % (p < 0.001) and 9 % (p < 0.001), respectively. Similar differences were observed in hair mineral content. Oppositely, children living in Tomino and Karabash were characterized by 10 (p = 0.002) and 23 % (p < 0.001) higher levels of blood phosphorus. At the same time, hair P content was maximal in a polluted area. Therefore, children living in a polluted area near a copper smelter had significantly higher values of heavy metals and decreased Mg and Ca content in biosamples. It is supposed that adverse health effects in persons living near a copper smelter may be associated not only with toxic metal overexposure but also with altered mineral homeostasis.
authors.affiliation: Laboratory of biotechnology and applied bioelementology, Yaroslavl State University, Sovetskaya st., 14, Yaroslavl, 150000, Russia.|Institute of Bioelementology (Russian Satellite Centre of Trace Element-Institute for UNESCO), Orenburg State University, Pobedy Ave. 13, Orenburg, 460352, Russia.|All-Russian Research Institute of Medicinal and Aromatic Plants (VILAR), Grina St., 7, Moscow, 117216, Russia.|RUDN University, Miklukho-Maklai str. 6, Moscow, 117198, Russia.
authors.forename: Anatoly V
authors.initials: AV
authors.lastname: Skalny
authors.affiliation: Federal Scientific Clinical Centre of Pediatric Hematology Oncology Immunology named after Dvitry Rogachev, Samory Mashela St., 1, 117997, Moscow, Russia.
authors.forename: Elena V
authors.initials: EV
authors.lastname: Zhukovskaya
authors.affiliation: Chelyabinsk Regional Pediatric Hospital, Bluchera St. 42a, Chelyabinsk, 454076, Russia.
authors.forename: Galina N
authors.initials: GN
authors.lastname: Kireeva
authors.affiliation: Russian Society of Trace Elements in Medicine, ANO "Centre for Biotic Medicine", Zemlyanoi Val St., 46, 105064, Moscow, Russia.|RUDN University, Miklukho-Maklai str. 6, Moscow, 117198, Russia.
authors.forename: Margarita G
authors.initials: MG
authors.lastname: Skalnaya
authors.affiliation: Laboratory of biotechnology and applied bioelementology, Yaroslavl State University, Sovetskaya st., 14, Yaroslavl, 150000, Russia.|Russian Society of Trace Elements in Medicine, ANO "Centre for Biotic Medicine", Zemlyanoi Val St., 46, 105064, Moscow, Russia.
authors.forename: Andrey R
authors.initials: AR
authors.lastname: Grabeklis
authors.affiliation: RUDN University, Miklukho-Maklai str. 6, Moscow, 117198, Russia.
authors.forename: Ivan V
authors.initials: IV
authors.lastname: Radysh
authors.affiliation: Kazakh Academy of Nutrition, Klochkov St., 66, Almaty, 050000, Republic of Kazakhstan.
authors.forename: Rosa A
authors.initials: RA
authors.lastname: Shakieva
authors.affiliation: Institute of Bioelementology (Russian Satellite Centre of Trace Element-Institute for UNESCO), Orenburg State University, Pobedy Ave. 13, Orenburg, 460352, Russia.|Department of Biochemistry, Orenburg State Medical University, Sovetskaya St., 6, Orenburg, 460000, Russia.
authors.forename: Alexandr A
authors.initials: AA
authors.lastname: Nikonorov
authors.affiliation: Laboratory of biotechnology and applied bioelementology, Yaroslavl State University, Sovetskaya st., 14, Yaroslavl, 150000, Russia. tinkov.a.a@gmail.com.|Institute of Bioelementology (Russian Satellite Centre of Trace Element-Institute for UNESCO), Orenburg State University, Pobedy Ave. 13, Orenburg, 460352, Russia. tinkov.a.a@gmail.com.|RUDN University, Miklukho-Maklai str. 6, Moscow, 117198, Russia. tinkov.a.a@gmail.com.|Department of Biochemistry, Orenburg State Medical University, Sovetskaya St., 6, Orenburg, 460000, Russia. tinkov.a.a@gmail.com.
authors.forename: Alexey A
authors.initials: AA
authors.lastname: Tinkov
mesh_terms: D000293:Adolescent; D002617:Chemical Industry; D003300:Copper / Q000097:blood*; D004787:Environmental Pollution / Q000032:analysis*; D006197:Hair / Q000737:chemistry; D006801:Humans; D008297:Male; D019216:Metals, Heavy / Q000097:blood; D008903:Minerals / Q000097:blood; D012426:Russia; D014131:Trace Elements / Q000097:blood*
chemical_list: D019216:Metals, Heavy; D008903:Minerals; D014131:Trace Elements; D003300:Copper
keywords: Antagonism; Arsenic; Calcium; Copper-smelter; Magnesium; Metal pollution