title: Augmentation Rhinoplasty With Silicone Implant Covered With Acellular Dermal Matrix.
abstract: BACKGROUND
  Alloplastic materials are a mainstay in Asian rhinoplasty. However, the outline of alloplastic implants can become conspicuous over time in rhinoplasty patients, which is a significant cause for revision. In revision rhinoplasty, alloplastic materials can remain a viable and affordable option in Asian patients. The acellular dermal matrices (ADM) are often used to interface between the silicone material and the skin envelope. This study assesses histologic changes following implantation of ADM-covered silicone material in rats.
  
  
  METHODS
  To demonstrate differences at the histologic level, silicone blocks with and without ADM were implanted in the subcutaneous plane of 10 rats. These implants were harvested after 9 weeks and examined histologically for capsule thickness and myofibroblast activity.
  
  
  RESULTS
  In the in vivo study, the presence of ADM was associated with significantly decreased capsule thickness and myofibroblast activity around the implant and maintained the structure of ADM well.
  
  
  CONCLUSIONS
  The authors suggest that using the ADMs to cover silicone implants can be an alternative method for decreasing the visibility of implant contour, by the prevention of capsular contracture and the addition of a soft tissue layer to the dorsal skin envelope.
authors.affiliation: *JW Plastic Surgery Center †CBK Plastic Surgery Clinic ‡Well Plastic Surgery Clinic, Seoul §L&C BIO Co/R&D Center, Seongnam ||Department of Plastic Surgery, SMG-SNU Boramae Medical Center ¶Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul National University, Seoul, Korea.
authors.forename: Man Koon
authors.initials: MK
authors.lastname: Suh
authors.forename: Kyo Ho
authors.initials: KH
authors.lastname: Lee
authors.forename: Aram
authors.initials: A
authors.lastname: Harijan
authors.forename: Hyung-Gu
authors.initials: HG
authors.lastname: Kim
authors.forename: Euicheol C
authors.initials: EC
authors.lastname: Jeong
mesh_terms: D062088:Acellular Dermis; D000818:Animals; D006801:Humans; D009666:Nose / Q000601:surgery; D019736:Prostheses and Implants; D011474:Prosthesis Design; D051381:Rats; D012086:Reoperation; D012225:Rhinoplasty / Q000379:methods*; D012828:Silicones
chemical_list: D012828:Silicones