title: Models for zero-inflated, correlated count data with extra heterogeneity: when is it too complex?
abstract: Statistical analysis of count data typically starts with a Poisson regression. However, in many real-life applications, it is observed that the variation in the counts is larger than the mean, and one needs to deal with the problem of overdispersion in the counts. Several factors may contribute to overdispersion: (1) unobserved heterogeneity due to missing covariates, (2) correlation between observations (such as in longitudinal studies), and (3) the occurrence of many zeros (more than expected from the Poisson distribution). In this paper, we discuss a model that allows one to explicitly take each of these factors into consideration. The aim of this paper is twofold: (1) investigate whether we can identify the cause of overdispersion via model selection, and (2) investigate the impact of a misspecification of the model on the power of a covariate. The paper is motivated by a study of the occurrence of drug-induced arrhythmia in beagle dogs based on electrocardiogram recordings, with the objective to evaluate the effect of potential drugs on the heartbeat irregularities. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Diepenbeek, 3590, Belgium.
authors.forename: Sammy
authors.initials: S
authors.lastname: Chebon
authors.affiliation: Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Diepenbeek, 3590, Belgium.
authors.forename: Christel
authors.initials: C
authors.lastname: Faes
authors.affiliation: Janssen Pharmaceutica NV, Turnhoutseweg 30, Beerse, 2340, Belgium.
authors.forename: Frank
authors.initials: F
authors.lastname: Cools
authors.affiliation: Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Diepenbeek, 3590, Belgium.|Janssen Pharmaceutica NV, Turnhoutseweg 30, Beerse, 2340, Belgium.
authors.forename: Helena
authors.initials: H
authors.lastname: Geys
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000662:veterinary; D056808:Biostatistics; D003198:Computer Simulation; D018592:Cross-Over Studies; D003627:Data Interpretation, Statistical; D004283:Dog Diseases / Q000139:chemically induced; D004285:Dogs; D006801:Humans; D008137:Longitudinal Studies; D015233:Models, Statistical; D016012:Poisson Distribution
keywords: ECG arrhythmia data; combined models; negative binomial model; overdispersion; random effect model; zero-inflated model