title: Nanostructured Boron Nitride With High Water Dispersibility For Boron Neutron Capture Therapy.
abstract: Highly water dispersible boron based compounds are innovative and advanced materials which can be used in Boron Neutron Capture Therapy for cancer treatment (BNCT). Present study deals with the synthesis of highly water dispersible nanostructured Boron Nitride (BN). Unique and relatively low temperature synthesis route is the soul of present study. The morphological examinations (Scanning/transmission electron microscopy) of synthesized nanostructures showed that they are in transient phase from two dimensional hexagonal sheets to nanotubes. It is also supported by dual energy band gap of these materials calculated from UV- visible spectrum of the material. The theoretically calculated band gap also supports the same (calculated by virtual nano lab Software). X-ray diffraction (XRD) analysis shows that the synthesized material has deformed structure which is further supported by Raman spectroscopy. The structural aspect of high water disperse ability of BN is also studied. The ultra-high disperse ability which is a result of structural deformation make these nanostructures very useful in BNCT. Cytotoxicity studies on various cell lines (Hela(cervical cancer), human embryonic kidney (HEK-293) and human breast adenocarcinoma (MCF-7)) show that the synthesized nanostructures can be used for BNCT.
authors.affiliation: Advanced Functional Materials Lab., Department of Nanotechnology, Sri Guru Granth Sahib World University, Fatehgarh Sahib, 140 407, Punjab, India.
authors.forename: Bikramjeet
authors.initials: B
authors.lastname: Singh
authors.affiliation: Advanced Functional Materials Lab., Department of Nanotechnology, Sri Guru Granth Sahib World University, Fatehgarh Sahib, 140 407, Punjab, India.
authors.forename: Gurpreet
authors.initials: G
authors.lastname: Kaur
authors.affiliation: Advanced Functional Materials Lab., Department of Nanotechnology, Sri Guru Granth Sahib World University, Fatehgarh Sahib, 140 407, Punjab, India.
authors.forename: Paviter
authors.initials: P
authors.lastname: Singh
authors.affiliation: Advanced Functional Materials Lab., Department of Nanotechnology, Sri Guru Granth Sahib World University, Fatehgarh Sahib, 140 407, Punjab, India.
authors.forename: Kulwinder
authors.initials: K
authors.lastname: Singh
authors.affiliation: Central Scientific Instruments Organization, Chandigarh, 160 030, India.
authors.forename: Baban
authors.initials: B
authors.lastname: Kumar
authors.affiliation: Department of Physics, Amity School of Applied Science, AMITY University Haryana, Gurgaon, 122 413, India.
authors.forename: Ankush
authors.initials: A
authors.lastname: Vij
authors.affiliation: Defence Institute of Advanced Technology (DU), Pune, 411 025, India.
authors.forename: Manjeet
authors.initials: M
authors.lastname: Kumar
authors.affiliation: Department of Mathematics, Punjabi University, Patiala, 147 002, Punjab, India.
authors.forename: Rajni
authors.initials: R
authors.lastname: Bala
authors.affiliation: Nanotoxicology laboratory, School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, 110 067, India.
authors.forename: Ramovatar
authors.initials: R
authors.lastname: Meena
authors.affiliation: Technical Physics Division, BARC, Mumbai, 400 085, India.
authors.forename: Ajay
authors.initials: A
authors.lastname: Singh
authors.affiliation: Department of Basic and Applied Sciences, Punjabi University, Patiala, 147 002, Punjab, India.
authors.forename: Anup
authors.initials: A
authors.lastname: Thakur
authors.affiliation: Advanced Functional Materials Lab., Department of Nanotechnology, Sri Guru Granth Sahib World University, Fatehgarh Sahib, 140 407, Punjab, India.
authors.forename: Akshay
authors.initials: A
authors.lastname: Kumar