title: Oxiracetam can improve cognitive impairment after chronic cerebral hypoperfusion in rats.
abstract: Chronic cerebral hypoperfusion (CCH) induces cognitive deficits. Although CCH can be improved, cognitive impairment is not improved accordingly. To date, many studies have focused on investigating the pathophysiological mechanisms of CCH; however, the treatment of the induced cognitive impairment remains ineffective. Thus, the mechanisms underlying cognitive impairment after CCH and potential agents for treating this impairment need to be explored further. Oxiracetam is a nootropic drug that improves clinical outcomes for some central nervous system (CNS) disorders. Whether it can improve cognitive impairment after CCH is unknown. In this study, we used behavioural methods, electrophysiology, biochemistry, histopathological staining and transmission electron microscope to investigate rat's cognitive impairment by CCH, and found that Oxiracetam could improve CCH-induced cognitive impairment and prevent deficits of neural plasticity, white matter lesions, and synaptic ultrastructure. These results suggest that Oxiracetam may be effective as a potential agent against CCH-induced cognitive impairment.
authors.affiliation: Department of Neurology, Central hospital of Zhengzhou, #195 Tongbo Road, Zhengzhou, China; Department of Neurology, Renmin hospital of Wuhan University, #238 Jiefang Road, Wuhan, China.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Yao
authors.affiliation: Department of Geriatrics, Renmin hospital of Wuhan University, #238 Jiefang Road, Wuhan, China; Department of Neurology, Renmin hospital of Wuhan University, #238 Jiefang Road, Wuhan, China. Electronic address: yaozhaohui2004@126.com.
authors.forename: Zhao-Hui
authors.initials: ZH
authors.lastname: Yao
authors.affiliation: Department of Geriatrics, Renmin hospital of Wuhan University, #238 Jiefang Road, Wuhan, China; Department of Neurology, Renmin hospital of Wuhan University, #238 Jiefang Road, Wuhan, China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Geriatrics, Renmin hospital of Wuhan University, #238 Jiefang Road, Wuhan, China; Department of Neurology, Renmin hospital of Wuhan University, #238 Jiefang Road, Wuhan, China.
authors.forename: Li
authors.initials: L
authors.lastname: Nie
authors.affiliation: Department of Geriatrics, Renmin hospital of Wuhan University, #238 Jiefang Road, Wuhan, China; Department of Neurology, Renmin hospital of Wuhan University, #238 Jiefang Road, Wuhan, China.
authors.forename: Shao-Feng
authors.initials: SF
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002561:Cerebrovascular Disorders / Q000150:complications*; D060825:Cognitive Dysfunction / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D004195:Disease Models, Animal; D008297:Male; D018697:Nootropic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D011759:Pyrrolidines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D018697:Nootropic Agents; D011759:Pyrrolidines; C040619:oxiracetam
keywords: Chronic cerebral hypoperfusion; Cognitive impairment; Oxiracetam