title: Unstable Angina: A Serious Adverse Event following Gemcitabine-Cisplatin Based Chemotherapy.
abstract: A 29 year male, with an inoperable adenocarcinoma of gall bladder was initiated on gemcitabine and a platinum compound based chemotherapy. During 4th cycle of chemotherapy, patient complained of chest pain following cisplatin and gemcitabine infusion. ECG was suggestive of acute coronary syndrome, which was successfully managed by antianginal therapy. Fifth cycle of chemotherapy was uneventful. Patient died of cardiovascular collapse before receiving the 6th cycle of chemotherapy. As per Naranjo adverse drug reaction probability scale, causal association of the event with cisplatin and gemcitabine was probable and possible respectively. It is advised to routinely assess the cardiovascular status of patients before and during cisplatin and/or gemcitabine based chemotherapy.
authors.affiliation: Professor and Head, Department of Pharmacology.
authors.forename: H S
authors.initials: HS
authors.lastname: Rehan
authors.affiliation: Professor, Department of Surgery.
authors.forename: M
authors.initials: M
authors.lastname: Andley
authors.affiliation: Technical Associate.
authors.forename: P
authors.initials: P
authors.lastname: Nagar
authors.affiliation: Senior Resident, Department of Pharmacology, Lady Hardinge Medical College and SSK Hospital, New Delhi.
authors.forename: V
authors.initials: V
authors.lastname: Maharshi
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy; D000328:Adult; D000789:Angina, Unstable / Q000139:chemically induced*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002945:Cisplatin / Q000009:adverse effects*; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives*; D017809:Fatal Outcome; D005706:Gallbladder Neoplasms / Q000188:drug therapy; D006801:Humans; D008297:Male; D000093542:Gemcitabine
chemical_list: D003841:Deoxycytidine; D002945:Cisplatin; D000093542:Gemcitabine