title: Serum Trace Elements and Electrolytes Are Associated with Fasting Plasma Glucose and HbA1cin Postmenopausal Women with Type 2 Diabetes Mellitus.
abstract: The primary aim of the research was to assess the level of trace elements and electrolytes in serum of postmenopausal diabetic women. Sixty-four postmenopausal women with type 2 diabetes mellitus (DM2) and 64 age- and body mass index-matched controls were examined. Serum trace elements were assessed using inductively coupled plasma dynamic reaction cell mass spectrometry (ICP-DRC-MS). Fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c) levels were evaluated using Randox kits. The obtained data demonstrate that DM2 patients were characterized by 42 and 34 % higher FPG and HbA1clevels, respectively (p < 0.001). The level of Cu and Se in diabetic postmenopausal women was increased by 10 and 15 % in comparison to the respective control values (p = 0.002 and <0.001). Serum Mn, Zn, and Ni concentrations were lower than the control ones by 32 % (p = 0.003), 8 % (p = 0.003), and 23 % (p = 0.046), respectively. FPG and HbA1clevels directly correlated with serum Se (p < 0.001) and Cu (p = 0.014 and p = 0.028) concentrations and inversely related to Zn (p < 0.001) and Tl (p = 0.023 and p = 0.029) levels. Multiple regression analysis demonstrated a significant association between serum Zn and Se and FPG and HbA1clevels. It is proposed that Zn and Se play an important role in DM2 pathogenesis. Further studies are required to assess the intimate mechanisms of the observed differences.
authors.affiliation: RUDN University, Moscow, Russia.|Russian Society of Trace Elements in Medicine, ANO "Center for Biotic Medicine", Moscow, Russia.
authors.forename: Margarita G
authors.initials: MG
authors.lastname: Skalnaya
authors.affiliation: RUDN University, Moscow, Russia.|Russian Society of Trace Elements in Medicine, ANO "Center for Biotic Medicine", Moscow, Russia.|Orenburg State University, Orenburg, Russia.|Yaroslavl State University, Yaroslavl, Russia.|All-Russian Research Institute of Medicinal and Aromatic Plants (VILAR), Moscow, Russia.
authors.forename: Anatoly V
authors.initials: AV
authors.lastname: Skalny
authors.affiliation: LLC Independent Laboratory "Invitro", Moscow, Russia.
authors.forename: Vasily V
authors.initials: VV
authors.lastname: Yurasov
authors.affiliation: Russian Society of Trace Elements in Medicine, ANO "Center for Biotic Medicine", Moscow, Russia.
authors.forename: Vasily A
authors.initials: VA
authors.lastname: Demidov
authors.affiliation: Russian Society of Trace Elements in Medicine, ANO "Center for Biotic Medicine", Moscow, Russia.|Yaroslavl State University, Yaroslavl, Russia.
authors.forename: Andrei R
authors.initials: AR
authors.lastname: Grabeklis
authors.affiliation: RUDN University, Moscow, Russia.
authors.forename: Ivan V
authors.initials: IV
authors.lastname: Radysh
authors.affiliation: RUDN University, Moscow, Russia. tinkov.a.a@gmail.com.|Orenburg State University, Orenburg, Russia. tinkov.a.a@gmail.com.|Yaroslavl State University, Yaroslavl, Russia. tinkov.a.a@gmail.com.|Orenburg State Medical University, Orenburg, Russia. tinkov.a.a@gmail.com.
authors.forename: Alexey A
authors.initials: AA
authors.lastname: Tinkov
mesh_terms: D001786:Blood Glucose / Q000032:analysis*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004573:Electrolytes / Q000097:blood; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D013058:Mass Spectrometry; D017698:Postmenopause / Q000097:blood*; D014131:Trace Elements / Q000097:blood*
chemical_list: D001786:Blood Glucose; D004573:Electrolytes; D006442:Glycated Hemoglobin; D014131:Trace Elements; C517652:hemoglobin A1c protein, human
keywords: Diabetes mellitus; Glucose; Menopause; Selenium; Zinc