title: Assessment of Irritation and Sensitization Potential of Eight Baby Skin Care Products.
abstract: BACKGROUND
  Ethnic differences in skin sensitivity suggest that greater emphasis be focused on understanding a product's effect in diverse populations.
  
  
  OBJECTIVE
  The irritation and/or sensitization potential of 8 baby skin care products in Indian adults were evaluated using cumulative irritation tests (CIT) and human repeat insult patch testing (HRIPT) protocols.
  
  
  METHODS
  Healthy males or females aged 18 to 65 years of Indian ethnicity were treated with each of 6 products (cream, hair oil, lotion, body wash, shampoo, and baby soap) using CIT (n = 25) and HRIPT (n = 200). Baby powder and baby oil were evaluated by CIT (n = 25) and HRIPT (n = 107) in separate studies. CITs were conducted over 14 days; HRIPTs were conducted over 10 weeks.
  
  
  RESULTS
  In both CIT and HRIPT, most products were considered mild, with no irritation. Baby soap and powder elicited reactions in the HRIPT induction phase, with positive challenge phase reactions (3 subjects), but were affirmed to be nonallergenic in the rechallenge phase.
  
  
  CONCLUSIONS
  In these studies, 8 baby skin care products were evaluated by both CIT and HRIPT in Indian adults. The results of the studies indicated that all of the tested products were nonallergenic and nonirritating. <br /><br /> <em>J Drugs Dermatol.</em> 2016;15(10):1244-1248.
authors.forename: Carlos
authors.initials: C
authors.lastname: Galzote
authors.forename: Mini
authors.initials: M
authors.lastname: Thomas
authors.forename: Mukta
authors.initials: M
authors.lastname: Sachdev
mesh_terms: D000293:Adolescent; D000328:Adult; D003358:Cosmetics / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006203:Hair Preparations / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007223:Infant; D008297:Male; D010328:Patch Tests / Q000379:methods*; D017592:Skin Care / Q000009:adverse effects / Q000379:methods*; D063465:Skin Cream / Q000008:administration & dosage* / Q000009:adverse effects; D023422:Skin Irritancy Tests / Q000379:methods*; D012915:Soaps / Q000008:administration & dosage* / Q000009:adverse effects; D055815:Young Adult
chemical_list: D003358:Cosmetics; D006203:Hair Preparations; D012915:Soaps