title: Mitochondrial dysfunction in obesity-related kidney disease: a novel therapeutic target.
abstract: Lipid accumulation in renal cells has been implicated in the pathogenesis of obesity-related kidney disease, but the underlying mechanism is poorly understood. Szeto et al. now unravel a central role of mitochondrial dysfunction in a high fat diet-induced glomerulopathy and proximal tubular injury. Moreover, they demonstrate the renoprotective effect of SS31, a mitochondria-targeted antioxidant, in related models. Targeting mitochondria may offer a novel strategy for the therapy of obesity-related kidney disease.
authors.affiliation: Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
authors.forename: Chengyuan
authors.initials: C
authors.lastname: Tang
authors.affiliation: Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Cai
authors.affiliation: Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China; Department of Cellular Biology & Anatomy, Medical College of Georgia at Georgia Regents University and Charlie Norwood VA Medical Center, Augusta, Georgia 30912, USA. Electronic address: zdong@gru.edu.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Dong
mesh_terms: D059305:Diet, High-Fat; D006801:Humans; D007674:Kidney Diseases; D008928:Mitochondria / Q000187:drug effects; D009765:Obesity; D018384:Oxidative Stress / Q000187:drug effects