title: Multidrug Resistance ofAcinetobacter Baumanniiin Ladoke Akintola University Teaching Hospital, Osogbo, Nigeria.
abstract: Acinetobacter baumanniiis a ubiquitous pathogen that has emerged as a major cause of healthcare-associated infections at Ladoke Akintola University Teaching Hospital. Isolates were assayed according to standard protocol. The isolates were subjected to molecular techniques to detectblaOXA, blaTEM, blaCTX-M, andblaSHVgenes in strains of theA. baumanniiisolates. The prevalence ofA. baumanniiwas 8.5% and was most prevalent among patients in the age group 51-60 (36%); the male patients (63.6%) were more infected than their female counterparts. Patients (72.7%) in the intensive care unit (ICU) were most infected with this organism. The isolates showed 100% resistance to both amikacin and ciprofloxacin and 90.9% to both ceftriaxone and ceftazidime, while resistance to the other antibiotics used in this study were: piperacillin (81.8%), imipenem (72.7%), gentamycin (72.2%), and meropenem (63.6%). None of the isolates was, however, resistant to colistin. PCR results showed thatblaOXA, blaTEM, andblaCTX-Mgenes were positive in some isolates, whileblaSHVwas not detected in any of the isolates. This study has revealed that the strains ofA. baumanniiisolated are multiple drug resistant. Regular monitoring, judicious prescription, and early detection of resistance to these antibiotics are, therefore, necessary to check further dissemination of the organism.
authors.affiliation: Department of Medical Microbiology and Parasitology, College of Health Sciences, P.M.B. 4400, Ladoke Akintola University of Technology (LAUTECH) , Osogbo, Osun State, Nigeria.
authors.forename: G
authors.initials: G
authors.lastname: Odewale
authors.affiliation: Department of Medical Microbiology and Parasitology, College of Health Sciences, P.M.B. 4400, Ladoke Akintola University of Technology (LAUTECH) , Osogbo, Osun State, Nigeria.
authors.forename: O J
authors.initials: OJ
authors.lastname: Adefioye
authors.affiliation: Department of Medical Microbiology and Parasitology, College of Health Sciences, P.M.B. 4400, Ladoke Akintola University of Technology (LAUTECH) , Osogbo, Osun State, Nigeria.
authors.forename: J
authors.initials: J
authors.lastname: Ojo
authors.affiliation: Department of Medical Microbiology and Parasitology, College of Health Sciences, P.M.B. 4400, Ladoke Akintola University of Technology (LAUTECH), Osogbo, Osun State, Nigeria; Department of Medical Laboratory Science, Afe Babalola University, P.M.B. 5454, Ado Ekiti, Ekiti State, Nigeria.
authors.forename: F A
authors.initials: FA
authors.lastname: Adewumi
authors.affiliation: Department of Medical Microbiology and Parasitology, College of Health Sciences, P.M.B. 4400, Ladoke Akintola University of Technology (LAUTECH) , Osogbo, Osun State, Nigeria.
authors.forename: O A
authors.initials: OA
authors.lastname: Olowe
keywords: Acinetobacter baumannii; Nigeria; antibiotic-resistant genes