title: Reduced rates of non-union with modified periacetabular osteotomy using peracetic-acid sterilized cancellous allografts.
abstract: The objective of the present study was to analyze the clinical and radiological results of periacetabular osteotomies (PAO) using Kirschner wire fixation and an allogeneic cancellous bone graft. This retrospective cohort study included 73 patients (85 PAOs). The allografts were processed from distal femur of cadaveric donors, defatted, sterilized with a peracetic-acid ethanol solution and freeze-dried. The clinical outcome, as measured by the Harris Hip Scores (HHS), the complication rate and the acetabular correction, as measured by radiological parameters, were compared. The postoperative femoral head coverage and HSS were significantly improved. Major complications occurred in five cases (6 %), but in no case did we observe a non-union or a graft-associated adverse effect. Fixation of the acetabular fragment with Kirschner wires in combination with an allogeneic cancellous bone graft is a safe method, with a low complication rate, no loss of correction and can prevent the occurrence of non-union with a high degree of probability.
authors.affiliation: Orthopedics Department, Center for Musculoskeletal Surgery, Charité - Universitätsmedizin Berlin, Rahel-Hirsch-Weg 5, 10117, Berlin, Germany. georgi.wassilew@charite.de.
authors.forename: Georgi I
authors.initials: GI
authors.lastname: Wassilew
authors.affiliation: Orthopedics Department, Center for Musculoskeletal Surgery, Charité - Universitätsmedizin Berlin, Rahel-Hirsch-Weg 5, 10117, Berlin, Germany.
authors.forename: Viktor
authors.initials: V
authors.lastname: Janz
authors.affiliation: Orthopedics Department, Center for Musculoskeletal Surgery, Charité - Universitätsmedizin Berlin, Rahel-Hirsch-Weg 5, 10117, Berlin, Germany.
authors.forename: Lisa
authors.initials: L
authors.lastname: Renner
authors.affiliation: Orthopedics Department, Center for Musculoskeletal Surgery, Charité - Universitätsmedizin Berlin, Rahel-Hirsch-Weg 5, 10117, Berlin, Germany.
authors.forename: Carsten
authors.initials: C
authors.lastname: Perka
authors.affiliation: University Tissue Bank, Institute of Transfusion Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Axel
authors.initials: A
authors.lastname: Pruss
mesh_terms: D000077:Acetabulum / Q000000981:diagnostic imaging / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D064591:Allografts / Q000737:chemistry*; D016025:Bone Transplantation / Q000379:methods; D004202:Disinfectants / Q000737:chemistry*; D005260:Female; D005612:Freeze Drying; D006801:Humans; D008297:Male; D008875:Middle Aged; D010027:Osteotomy / Q000379:methods; D010463:Peracetic Acid / Q000737:chemistry*; D011859:Radiography; D012189:Retrospective Studies; D013242:Sterilization / Q000379:methods; D055815:Young Adult
chemical_list: D004202:Disinfectants; D010463:Peracetic Acid
keywords: Allografts; Kirschner wire; Peracetic acid; Periacetabular osteotomy; Tissue bank