title: Nanomedicine in Central Nervous System (CNS) Disorders: A Present and Future Prospective.
abstract: Purpose:For the past few decades central nervous system disorders were considered as a major strike on human health and social system of developing countries. The natural therapeutic methods for CNS disorders limited for many patients. Moreover, nanotechnology-based drug delivery to the brain may an exciting and promising platform to overcome the problem of BBB crossing. In this review, first we focused on the role of the blood-brain barrier in drug delivery; and second, we summarized synthesis methods of nanomedicine and their role in different CNS disorder.Method:We reviewed the PubMed databases and extracted several kinds of literature on neuro nanomedicines using keywords, CNS disorders, nanomedicine, and nanotechnology. The inclusion criteria included chemical and green synthesis methods for synthesis of nanoparticles encapsulated drugs and, their in-vivo and in-vitro studies. We excluded nanomedicine gene therapy and nanomaterial in brain imaging.Results:In this review, we tried to identify a highly efficient method for nanomedicine synthesis and their efficacy in neuronal disorders. SLN and PNP encapsulated drugs reported highly efficient by easily crossing BBB. Although, these neuro-nanomedicine play significant role in therapeutics but some metallic nanoparticles reported the adverse effect on developing the brain.Conclusion:Although impressive advancement has made via innovative potential drug development, but their efficacy is still moderate due to limited brain permeability. To overcome this constraint,powerful tool in CNS therapeutic intervention provided by nanotechnology-based drug delivery methods. Due to its small and biofunctionalization characteristics, nanomedicine can easily penetrate and facilitate the drug through the barrier. But still, understanding of their toxicity level, optimization and standardization are a long way to go.
authors.affiliation: Department of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh, 160012, India.
authors.forename: Shringika
authors.initials: S
authors.lastname: Soni
authors.affiliation: Department of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh, 160012, India.
authors.forename: Rakesh Kumar
authors.initials: RK
authors.lastname: Ruhela
authors.affiliation: Department of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh, 160012, India.
authors.forename: Bikash
authors.initials: B
authors.lastname: Medhi
keywords: Blood brain barrier; CNS therapeutics; Drug delivery; Nanocarrier; Nanomedicine; Nanotechnology