title: Class II-Restricted CD8s: New Lessons Violate Old Paradigms.
abstract: CD8+T cells that recognize peptides presented by MHC class II molecules have been observed in a macaque SIV vaccine model. A new study by Ranasinghe et al. (2016) shows that virus-specific class-II-restricted CD8+T cells can be found in some HIV-infected patients.
authors.affiliation: HIV-Specific Immunity Section, Laboratory of Immunoregulation, Division of Intramural Research NIAID, Bethesda, MD 20892, USA.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Migueles
authors.affiliation: HIV-Specific Immunity Section, Laboratory of Immunoregulation, Division of Intramural Research NIAID, Bethesda, MD 20892, USA. Electronic address: mconnors@nih.gov.
authors.forename: Mark
authors.initials: M
authors.lastname: Connors
mesh_terms: D000818:Animals; D006801:Humans; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D018449:SAIDS Vaccines / Q000276:immunology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology; D015302:Simian Immunodeficiency Virus / Q000276:immunology
chemical_list: D000949:Histocompatibility Antigens Class II; D018449:SAIDS Vaccines