title: Efficacy of Liposomal Bupivacaine Infiltration on the Management of Total Knee Arthroplasty.
abstract: Liposomal bupivacaine is a novel extended-duration anesthetic that has recently been used for local infiltration in total knee arthroplasty (TKA). Athough liposomal bupivacaine is widely used, it is unknown if the benefits justify the cost in the veteran population at our institution.
  
  
  
  To evaluate a change in practice: the effect of local infiltration of liposomal bupivacaine on perioperative outcomes in patients undergoing primary TKA.
  
  
  
  A retrospective cohort study was conducted among patients who underwent primary TKA at a Veterans Affairs Medical Center before (March 3, 2013-March 2, 2014) and after (March 3, 2014-March 2, 2015) the implementation of liposomal bupivacaine for local infiltration in TKA.
  
  
  
  Drug utilization evaluation of liposomal bupivacaine for local infiltration in TKA.
  
  
  
  Use of opioids after discharge from the postanesthesia care unit.
  
  
  
  Among 199 patients, those who received liposomal bupivacaine after primary TKA (mean [SD] age, 65.3 [6.9] years; 93 males and 5 females) had a reduced median opioid use in the first 24 hours after surgery compared with those who did not receive liposomal bupivacaine (mean [SD] age, 64.9 [8.4] years; 95 males and 6 females; [intravenous morphine equivalents, 12.50 vs 22.50 mg; P = .001]). The use of patient-controlled analgesia was also reduced among patients who received liposomal bupivacaine vs those who did not (49 vs 91; P < .001). A reduction in the use of antiemetics was observed in the first 24 hours after surgery (13 vs 34; P = .001) and in the postanesthesia care unit among those who received liposomal bupivacaine vs those who did not (4 vs 20; P = .001). The number of patients in the postanesthesia care unit with no pain was improved among those who received liposomal bupivacaine vs those who did not (44 vs 19; P < .001). Although median (interquartile range) pain scores in the postanesthesia care unit were improved among patients who received liposomal bupivacaine vs those who did not (4.0 [0.0-6.6] vs 5.5 [3.0-7.5]; P = .001), patients who received liposomal bupivacaine had greater median (interquartile range) pain scores 48 hours (5.5 [4.0-7.0] vs 5.0 [3.0-6.0]; P = .01), 72 hours (5.0 [4.0-6.0] vs 4.0 [2.0-6.0]; P = .002), and 96 hours (5.0 [3.0-6.5] vs 4.0 [1.0-5.0]; P = .003) after surgery than those who did not receive liposomal bupivacaine. There was no difference in the median length of stay between the 2 groups. Institutional cost savings was estimated at $27 000 per year.
  
  
  
  Local infiltration of liposomal bupivacaine reduces use of opioids in the first 24 hours after primary TKA. Similarly, reduction in antiemetic use and improved postoperative pain are also seen in the first 24 hours after surgery but are limited to this time frame. Furthermore, a positive institutional cost savings was observed.
authors.affiliation: Department of Anesthesia, Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana2Department of Anesthesia, Indiana University School of Medicine, Indianapolis.
authors.forename: Bryan
authors.initials: B
authors.lastname: Sakamoto
authors.affiliation: Department of Pharmacy, Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana.
authors.forename: Shelly
authors.initials: S
authors.lastname: Keiser
authors.affiliation: Department of Orthopedic Surgery, Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana5Department of Orthopedic Surgery, Indiana University School of Medicine, Indianapolis.
authors.forename: Russell
authors.initials: R
authors.lastname: Meldrum
authors.affiliation: Department of Anesthesia, Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana2Department of Anesthesia, Indiana University School of Medicine, Indianapolis.
authors.forename: Gene
authors.initials: G
authors.lastname: Harker
authors.affiliation: Department of Orthopedic Surgery, Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana5Department of Orthopedic Surgery, Indiana University School of Medicine, Indianapolis.
authors.forename: Andrew
authors.initials: A
authors.lastname: Freese
mesh_terms: D000368:Aged; D016058:Analgesia, Patient-Controlled; D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000191:economics; D000772:Anesthesia, Local / Q000379:methods*; D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000191:economics; D000932:Antiemetics / Q000627:therapeutic use; D019645:Arthroplasty, Replacement, Knee; D002045:Bupivacaine / Q000008:administration & dosage* / Q000191:economics; D017046:Cost Savings; D005260:Female; D006801:Humans; D065186:Interrupted Time Series Analysis; D008081:Liposomes; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy; D011184:Postoperative Period; D012189:Retrospective Studies
chemical_list: D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D000932:Antiemetics; D008081:Liposomes; D002045:Bupivacaine