title: Neutrophil to Lymphocyte Ratio (NLR) and Derived Neutrophil to Lymphocyte Ratio (d-NLR) Predict Non-Responders and Postoperative Complications in Patients Undergoing Radical Surgery After Neo-Adjuvant Radio-Chemotherapy for Rectal Adenocarcinoma.
abstract: In order to evaluate neutrophil-to-lymphocyte ratio (NLR) and derived neutrophil-to-lymphocyte ratio (d-NLR) in predicting response and complications in rectal cancer patients who underwent surgery after neo-adjuvant radio-chemotherapy, 87 patients were evaluated. Cutoffs before and after radio-chemotherapy were respectively 2.8 and 3.8 for NLR, and 1.4 and 2.3 for d-NLR. They were analyzed in relation to clinical and pathological outcomes. Patients with preoperative NLR and d-NLR higher than cutoffs had significantly higher rates of tumor regression grade response (TRG ≥ 4) and postoperative complications. Elevated NLR and d-NLR after radio-chemotherapy are associated with worse pathological and clinical outcome.
authors.affiliation: a Department of General Surgery , University Campus Bio-Medico di Roma , Rome , Italy.
authors.forename: Damiano
authors.initials: D
authors.lastname: Caputo
authors.affiliation: a Department of General Surgery , University Campus Bio-Medico di Roma , Rome , Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Caricato
authors.affiliation: b International PhD Programme in Endocrinology and Metabolic Diseases, University Campus Bio-Medico di Roma , Rome , Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Coppola
authors.affiliation: a Department of General Surgery , University Campus Bio-Medico di Roma , Rome , Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: La Vaccara
authors.affiliation: c Department of Radiation Oncology , University Campus Bio-Medico di Roma , Rome , Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Fiore
authors.affiliation: a Department of General Surgery , University Campus Bio-Medico di Roma , Rome , Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Coppola
keywords: colorectal and anal cancer; detection/diagnosis; prognosis and response predictions