title: Breast Cancer and Deodorants/Antiperspirants: a Systematic Review.
abstract: Over the last decade, the possible association between underarm deodorants/ antiperspirants use and breast cancer risk has raised important interest in the scientific community. The objective of our systematic review is to estimate the pooled risk of deodorants/antiperspirants use for breast cancer.
  
  
  
  All observational studies that evaluated the association between breast cancer risk and deodorants/antiperspirants use were reviewed. We have only identified two case-control studies, carried out between 2002 and 2006.
  
  
  
  The first study was conducted in USA and investigated the possible relationship between use of products applied for underarm perspiration and the risk for breast cancer in women aged 20-74 years. This population-based case-control study gathered information by in-person interview. The second study was conducted in Iraq and investigated the possible relationship between use of antiperspirants and the risk for breast cancer in women attending a teaching hospital. This study also gathered information by in-person interview. There was no risk of antiperspirants use in the pooled risk (odds ratio 0.40, 95% confidence interval 0.35-0.46).
  
  
  
  Our comprehensive search has identified an insufficient number of studies to conduct a quantitative review and obtain reliable results. Further prospective studies are strongly needed.
authors.affiliation: Department of Preventive Medicine and Public Health, Faculty of Medicine, University of Cordoba, Spain.
authors.forename: Mohamed Farouk
authors.initials: MF
authors.lastname: Allam
mesh_terms: D017607:Aluminum Compounds / Q000009:adverse effects; D051520:Antiperspirants / Q000009:adverse effects* / Q000737:chemistry; D001943:Breast Neoplasms / Q000139:chemically induced* / Q000473:pathology; D003836:Deodorants / Q000009:adverse effects* / Q000737:chemistry; D005260:Female; D006801:Humans; D010226:Parabens / Q000009:adverse effects; D012307:Risk Factors
chemical_list: D017607:Aluminum Compounds; D051520:Antiperspirants; D003836:Deodorants; D010226:Parabens
keywords: Cancer; antiperspirants; breast; case-control; cohort; deodorants; meta-analysis; systematic review