title: Nickel-Catalyzed Monofluoroalkylation of Arylsilanes via Hiyama Cross-Coupling.
abstract: The first example of nickel-catalyzed monofluoroalkylation of arylsilanes has been developed with readily available fluoroalkyl halides. This novel transformation has demonstrated high reactivity, broad substrate scope, excellent functional group tolerance, and mild reaction conditions. The selective activation of a relatively inert C-Si bond for slow release of aryl carbanion is the key reason for reducing the amount of arylmetal species, which makes this method more promising for fluorine-containing modification of complex bioactive molecules. Mechanistic investigations indicate that a free fluoroalkyl radical is involved in this catalytic cycle.
authors.affiliation: Department of Chemistry, University of Science and Technology of China , Hefei 230026, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Chemistry, University of Science and Technology of China , Hefei 230026, China.
authors.forename: Hao-Ran
authors.initials: HR
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, University of Science and Technology of China , Hefei 230026, China.
authors.forename: Yi-Xuan
authors.initials: YX
authors.lastname: Cao
authors.affiliation: Department of Chemistry, University of Science and Technology of China , Hefei 230026, China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Lan
authors.affiliation: Department of Chemistry, University of Science and Technology of China , Hefei 230026, China.|Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry , Shanghai 200032, China.
authors.forename: Xi-Sheng
authors.initials: XS
authors.lastname: Wang