title: Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.
abstract: A workshop was sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases to focus on research gaps and opportunities in chronic pancreatitis (CP) and its sequelae. This conference marked the 20th year anniversary of the discovery of the cationic trypsinogen (PRSS1) gene mutation for hereditary pancreatitis. The event was held on July 27, 2016, and structured into 4 sessions: (1) pathophysiology, (2) exocrine complications, (3) endocrine complications, and (4) pain. The current state of knowledge was reviewed; many knowledge gaps and research needs were identified that require further investigation. Common themes included the need to design better tools to diagnose CP and its sequelae early and reliably, identify predisposing risk factors for disease progression, develop standardized protocols to distinguish type 3c diabetes mellitus from other types of diabetes, and design effective therapeutic strategies through novel cell culture technologies, animal models mimicking human disease, and pain management tools. Gene therapy and cystic fibrosis conductance regulator potentiators as possible treatments of CP were discussed. Importantly, the need for CP end points and intermediate targets for future drug trials was emphasized.
authors.affiliation: From the *Division of Gastroenterology, Hepatology, Nutrition, Stead Family Department of Pediatrics, The University of Iowa, Iowa City, IA; †The Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD; ‡Departments of Pediatrics and Surgery, University of Minnesota Medical School, Minneapolis, MN; §Faculty of Life Sciences, University of Manchester, Manchester, UK; ∥Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark; ¶Department of Anatomy and Cell Biology, University of Iowa, Iowa City, IA; #Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, Gainesville, FL; **Department of Medicine, University Medicine Greifswald, Greifswald, Germany; ††Division of Gastroenterology, Hepatology, Nutrition, Department of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, PA; ‡‡Division of Gastroenterology and Hepatology, Saint Louis University, St Louis, MO; §§Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA; ∥∥Center for Child Health, Behavior, and Development, Seattle Children's Research Institute, University of Washington, Seattle, WA; ¶¶Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; ##Department of Surgery, University of Miami Miller School of Medicine, Miami, FL; and ***Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH.
authors.forename: Aliye
authors.initials: A
authors.lastname: Uc
authors.forename: Dana K
authors.initials: DK
authors.lastname: Andersen
authors.forename: Melena D
authors.initials: MD
authors.lastname: Bellin
authors.forename: Jason I
authors.initials: JI
authors.lastname: Bruce
authors.forename: Asbjørn M
authors.initials: AM
authors.lastname: Drewes
authors.forename: John F
authors.initials: JF
authors.lastname: Engelhardt
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Forsmark
authors.forename: Markus M
authors.initials: MM
authors.lastname: Lerch
authors.forename: Mark E
authors.initials: ME
authors.lastname: Lowe
authors.forename: Brent A
authors.initials: BA
authors.lastname: Neuschwander-Tetri
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: OʼKeefe
authors.forename: Tonya M
authors.initials: TM
authors.lastname: Palermo
authors.forename: Pankaj
authors.initials: P
authors.lastname: Pasricha
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Saluja
authors.forename: Vikesh K
authors.initials: VK
authors.lastname: Singh
authors.forename: Eva M
authors.initials: EM
authors.lastname: Szigethy
authors.forename: David C
authors.initials: DC
authors.lastname: Whitcomb
authors.forename: Dhiraj
authors.initials: D
authors.lastname: Yadav
authors.forename: Darwin L
authors.initials: DL
authors.lastname: Conwell
mesh_terms: D000818:Animals; D003920:Diabetes Mellitus; D006801:Humans; D009154:Mutation; D054586:National Institute of Diabetes and Digestive and Kidney Diseases (U.S.); D050500:Pancreatitis, Chronic; D014357:Trypsin; D014359:Trypsin Inhibitor, Kazal Pancreatic; D014362:Trypsinogen; D014481:United States
chemical_list: D014359:Trypsin Inhibitor, Kazal Pancreatic; D014362:Trypsinogen; D014357:Trypsin