title: Nigella sativa Oil Reduces Extrapyramidal Symptoms (EPS)-Like Behavior in Haloperidol-Treated Rats.
abstract: The symptoms of Parkinsonism and oral dyskinesia have been showing to be induced by neuroleptics that significantly affect its clinical use. In this study, we investigate whether Nigella sativa-oil (NS) (black cumin seeds)-a traditional medicine used for the seizure treatment in eastern country-may reduce the haloperidol (HAL)-induced extrapyramidal symptoms (EPS)-like behavior in rats. After combine treatment with HAL (1 mg/kg) on NS (0.2 ml/rat), rats displayed a significant decreased EPS-like behavior including movement disorders and oral dyskinesia as compared to controls. Immunohistochemical analysis indicates that NS reduced astrogliosis in caudate and accumbens nuclei. These results suggest that NS may consider as an adjunct to antipsychotics to reduce the EPS-like side effect.
authors.affiliation: Neurochemistry and Biochemical Neuropharmacology Unit, Department of Biochemistry, The University of Karachi, Karachi, 75270, Pakistan. tafheemm85@gmail.com.|Basic Sciences, Physiology, National University of Health Sciences, Lombard, IL, USA. tafheemm85@gmail.com.|Histopathology Unit, Department of Pathology and Microbiology, The Aga Khan University Hospital, Karachi, Pakistan. tafheemm85@gmail.com.
authors.forename: Tafheem
authors.identifier: http://orcid.org/0000-0002-0975-1906
authors.initials: T
authors.lastname: Malik
authors.affiliation: Histopathology Unit, Department of Pathology and Microbiology, The Aga Khan University Hospital, Karachi, Pakistan.
authors.forename: Sheema
authors.initials: S
authors.lastname: Hasan
authors.affiliation: Histopathology Unit, Department of Pathology and Microbiology, The Aga Khan University Hospital, Karachi, Pakistan.
authors.forename: Shahid
authors.initials: S
authors.lastname: Pervez
authors.affiliation: Department of Anatomy, United Medical and Dental College, Karachi, Pakistan.
authors.forename: Tasneem
authors.initials: T
authors.lastname: Fatima
authors.affiliation: Neurochemistry and Biochemical Neuropharmacology Unit, Department of Biochemistry, The University of Karachi, Karachi, 75270, Pakistan.|Neuroscience Research Laboratory, Dr Panjwani Center for Molecular Medicine and Drug Research, The University of Karachi, Karachi, Pakistan.
authors.forename: Darakhshan Jabeen
authors.initials: DJ
authors.lastname: Haleem
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001253:Astrocytes / Q000187:drug effects / Q000473:pathology; D001480:Basal Ganglia Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D002421:Caudate Nucleus / Q000187:drug effects / Q000473:pathology; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy* / Q000473:pathology; D005911:Gliosis / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology; D006220:Haloperidol / Q000009:adverse effects*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D031881:Nigella sativa / Q000737:chemistry*; D009714:Nucleus Accumbens / Q000187:drug effects / Q000473:pathology; D010938:Plant Oils / Q000494:pharmacology*; D017208:Rats, Wistar; D000071057:Tardive Dyskinesia / Q000188:drug therapy / Q000473:pathology
chemical_list: D014150:Antipsychotic Agents; D010938:Plant Oils; D006220:Haloperidol
keywords: Astrogliosis; Caudate; Dyskinesia; Glial fibrillary acidic protein; Haloperidol; Nigella sativa oil; Nissl bodies; Nucleus accumbens; Parkinsonism; Rats; Striatum