title: Donations After Circulatory Death in Liver Transplant.
abstract: The supply of liver grafts for treatment of end-stage liver disease continues to fall short of ongoing demands. Currently, most liver transplants originate from donations after brain death. Enhanced utilization of the present resources is prudent to address the needs of the population. Donation after circulatory or cardiac death is a mechanism whereby the availability of organs can be expanded. Donations after circulatory death pose unique challenges given their exposure to warm ischemia. Technical principles of donations after circulatory death procurement and pertinent studies investigating patient outcomes, graft outcomes, and complications are highlighted in this review. We also review associated risk factors to suggest potential avenues to achieve improved outcomes and reduced complications. Future considerations and alternative techniques of organ preservation are discussed, which may suggest novel strategies to enhance preservation and donor expansion through the use of marginal donors. Ultimately, without effective measures to bolster organ supply, donations after circulatory death should remain a consideration; however, an understanding of inherent risks and limitations is necessary.
authors.affiliation: From the Department of Surgery, Division of Transplantation and The Collaboration for Organ Perfusion, Protection, Engineering and Regeneration (COPPER) Laboratory, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
authors.forename: Emre A
authors.initials: EA
authors.lastname: Eren
authors.forename: Nicholas
authors.initials: N
authors.lastname: Latchana
authors.forename: Eliza
authors.initials: E
authors.lastname: Beal
authors.forename: Don
authors.initials: D
authors.lastname: Hayes
authors.forename: Bryan
authors.initials: B
authors.lastname: Whitson
authors.forename: Sylvester M
authors.initials: SM
authors.lastname: Black
mesh_terms: D001926:Brain Death; D002423:Cause of Death; D046148:Donor Selection; D006331:Heart Diseases / Q000401:mortality*; D017052:Hospital Mortality; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D018570:Risk Assessment; D012307:Risk Factors; D012769:Shock / Q000401:mortality*; D014019:Tissue Donors / Q000600:supply & distribution*; D009927:Tissue and Organ Procurement / Q000379:methods*; D016896:Treatment Outcome