title: Brain transcriptomes of honey bees (Apis mellifera) experimentally infected by two pathogens: Black queen cell virus andNosema ceranae.
abstract: Regulation of gene expression in the brain plays an important role in behavioral plasticity and decision making in response to external stimuli. However, both can be severely affected by environmental factors, such as parasites and pathogens. In honey bees, the emergence and re-emergence of pathogens and potential for pathogen co-infection and interaction have been suggested as major components that significantly impaired social behavior and survival. To understand how the honey bee is affected and responds to interacting pathogens, we co-infected workers with two prevalent pathogens of different nature, the positive single strand RNA virus Black queen cell virus (BQCV), and the MicrosporidiaNosema ceranae, and explored gene expression changes in brains upon single infections and co-infections. Our data provide an important resource for research on honey bee diseases, and more generally on insect host-pathogen and pathogen-pathogen interactions. Raw and processed data are publicly available in the NCBI/GEO database: (http://www.ncbi.nlm.nih.gov/geo/) under accession number GSE81664.
authors.affiliation: Institut für Biologie, Martin-Luther-Universität Halle-Wittenberg, 06099 Halle (Salle), Germany; German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig, Deutscher Platz 5e, 04103 Leipzig, Germany; Centre for Ecology and Conservation, University of Exeter, Penryn Campus, Penryn TR11 9FE, UK.
authors.forename: Vincent
authors.initials: V
authors.lastname: Doublet
authors.affiliation: Institut für Biologie, Martin-Luther-Universität Halle-Wittenberg, 06099 Halle (Salle), Germany; German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig, Deutscher Platz 5e, 04103 Leipzig, Germany.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Paxton
authors.affiliation: INRA, UR 406 Abeilles et Environnement, 84914 Avignon Cedex 09, France.
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: McDonnell
authors.affiliation: MGX-Montpellier GenomiX, Institut de Génomique Fonctionnelle, 141 rue de la Cardonille, 34094 Cedex 5 Montpellier, France.
authors.forename: Emeric
authors.initials: E
authors.lastname: Dubois
authors.affiliation: MGX-Montpellier GenomiX, Institut de Génomique Fonctionnelle, 141 rue de la Cardonille, 34094 Cedex 5 Montpellier, France.
authors.forename: Sabine
authors.initials: S
authors.lastname: Nidelet
authors.affiliation: Institut für Biologie, Martin-Luther-Universität Halle-Wittenberg, 06099 Halle (Salle), Germany; German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig, Deutscher Platz 5e, 04103 Leipzig, Germany.
authors.forename: Robin F A
authors.initials: RF
authors.lastname: Moritz
authors.affiliation: INRA, UR 406 Abeilles et Environnement, 84914 Avignon Cedex 09, France.
authors.forename: Cédric
authors.initials: C
authors.lastname: Alaux
authors.affiliation: INRA, UR 406 Abeilles et Environnement, 84914 Avignon Cedex 09, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Le Conte
keywords: BQCV; Disease; Honeybee; Parasite; Virus