title: New Role of Hispidulin in Lipid Metabolism: PPARα Activator.
abstract: Hispidulin is a naturally occurring flavonoid isolated from a traditional Chinese medicinal herb, Saussurea involucrata. In this study, the regulating role of hispidulin on the mRNA expression level of enzymes involved in lipid metabolism was examined in vitro and in vivo. Moreover, the in vivo lipid-modulating effect of hispidulin was compared with that of fenofibrate, a classical PPARα agonist. Our results in present study demonstrated that hispidulin can directly bind to and activate PPARα as an agonist and thus modulate the downstream lipid-metabolizing genes. Moreover, hispidulin could attenuate dyslipidemia in high fat diet induced dyslipidemia rat model. Although further studies are needed, this study provided evidence for the potential use of hispidulin in dyslipidemia management.
authors.affiliation: Department of Endocrinology, The Affiliated Jiangyin People's Hospital, School of Medicine, Southeast University, Jiangyin, 214400, China.
authors.forename: Xinchi
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Endocrinology, The Affiliated Jiangyin People's Hospital, School of Medicine, Southeast University, Jiangyin, 214400, China. juanxujiangyin@yahoo.com.
authors.forename: Juan
authors.initials: J
authors.lastname: Xu
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D050171:Dyslipidemias / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D047309:Flavones / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D005786:Gene Expression Regulation / Q000187:drug effects; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D047493:PPAR alpha / Q000819:agonists* / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D030441:Saussurea / Q000737:chemistry
chemical_list: D004365:Drugs, Chinese Herbal; D047309:Flavones; D047493:PPAR alpha; D012333:RNA, Messenger; C055957:hispidulin
keywords: Dyslipidemia; Hispidulin; PPARα