title: Correlation of angiotensin I-converting enzyme gene insertion/deletion polymorphism with rheumatic heart disease: a meta-analysis.
abstract: Rheumatic heart disease (RHD) is a serious cardiovascular disorder worldwide. Several articles have reported the effect of angiotensin I-converting enzyme gene insertion/deletion (ACE I/D) polymorphism in RHD risk. However, the results still remain inconsistent. The objective of the present study was to assess more precise estimations of the relationship between ACE I/D variant and RHD susceptibility. Relevant case-control studies published between January 2000 and 2016 were searched in the electronic databases. The odds ratio (OR) with its 95% confidence interval (CI) was employed to calculate the strength of the effect. A total of nine articles were retrieved, including 1333 RHD patients and 1212 healthy controls. Overall, our result did not detect a significant association between ACE I/D polymorphism and RHD risk under each genetic model (P > 0.05). Subgroup analysis by ethnicity showed no positive relationship in Asians as well (P > 0.05). With respect to the severity of RHD, our result found that the frequency differences between mitral valve lesion (MVL), combined valve lesion (CVL) and healthy controls were not significantly different. Furthermore, no significant association was found between female, male RHD patients and the controls regarding to the ACE I/D polymorphism. In conclusion, our result indicated that ACE I/D polymorphism might not be a risk factor for RHD progression based on the existing research results. Additional well-designed studies with larger samples are still needed to confirm these findings.
authors.affiliation: Department of Cardiology, People's Hospital of Xuyi, Xuyi 211700, Jiangsu, P.R. China.
authors.forename: Yulong
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Department of Cardiology, People's Hospital of Xuyi, Xuyi 211700, Jiangsu, P.R. China.
authors.forename: Zhongchun
authors.initials: Z
authors.lastname: Ge
authors.affiliation: Department of Cardiology, People's Hospital of Xuyi, Xuyi 211700, Jiangsu, P.R. China.
authors.forename: Yuliang
authors.initials: Y
authors.lastname: Xing
authors.affiliation: Department of Cardiology, People's Hospital of Xuyi, Xuyi 211700, Jiangsu, P.R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Infectious Diseases, People's Hospital of Xuyi, Xuyi 211700, Jiangsu, P.R. China jying8611@yeah.net.
authors.forename: Jie
authors.initials: J
authors.lastname: Ying
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D005260:Female; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016254:Mutagenesis, Insertional / Q000235:genetics*; D016017:Odds Ratio; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D012214:Rheumatic Heart Disease / Q000235:genetics*; D012307:Risk Factors; D017384:Sequence Deletion / Q000235:genetics*; D055815:Young Adult
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A
keywords: angiotensin I-converting enzyme; meta-analysis; polymorphism; rheumatic heart disease