title: Long-Term Mortality and Quality of Life After Transcatheter Aortic Valve Insertion in Very Elderly Patients.
abstract: BACKGROUND
  We sought to compare long-term mortality and quality of life (QoL) in very elderly (≥80 years) patients undergoing transcatheter aortic valve implantation (TAVI) in comparison with younger patients (<80 years).
  
  
  METHODS
  A total of 101 patients treated with TAVI were divided into two groups according to age: <80 years (n = 42; 41.6%) and ≥80 years (n = 59; 58.4%). The baseline characteristics, including procedural outcomes as well as frailty and QoL assessment were compared between age groups.
  
  
  RESULTS
  Very elderly patients (≥80 years) were more frequently female, with a higher estimated risk of death based on STS score. Other baseline characteristics, including frailty indices, were comparable between groups. No difference in complication rate between age groups was observed. At 12 months, mortality rates were comparable for patients <80 years vs ≥80 years (16.7% vs 18.6%, respectively; P=.99). An improvement in QoL after 12 months as assessed by EQ-5D-3L was confirmed for both age groups, but with more pronounced beneficial effect of TAVI in younger patients.
  
  
  CONCLUSIONS
  The results of our single-center study showed that older age does not seem to be associated with impaired clinical outcomes after TAVI. However, benefit of TAVI in terms of long-term QoL improvement may be less apparent in very elderly patients.
authors.affiliation: Institute of Cardiology, University Hospital, Kopernika 17 Street, 31-501 Krakow, Poland. kleczu@interia.pl.
authors.forename: Pawel
authors.initials: P
authors.lastname: Kleczynski
authors.forename: Artur
authors.initials: A
authors.lastname: Dziewierz
authors.forename: Maciej
authors.initials: M
authors.lastname: Bagienski
authors.forename: Lukasz
authors.initials: L
authors.lastname: Rzeszutko
authors.forename: Danuta
authors.initials: D
authors.lastname: Sorysz
authors.forename: Jaroslaw
authors.initials: J
authors.lastname: Trebacz
authors.forename: Robert
authors.initials: R
authors.lastname: Sobczynski
authors.forename: Marek
authors.initials: M
authors.lastname: Tomala
authors.forename: Andrzej
authors.initials: A
authors.lastname: Gackowski
authors.forename: Dariusz
authors.initials: D
authors.lastname: Dudek
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000175:diagnosis; D005260:Female; D016330:Frail Elderly; D000073496:Frailty / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D006306:Health Surveys; D006801:Humans; D000069451:Long Term Adverse Effects / Q000209:etiology / Q000401:mortality*; D008297:Male; D011044:Poland / Q000453:epidemiology; D011788:Quality of Life; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors; D065467:Transcatheter Aortic Valve Replacement / Q000009:adverse effects / Q000379:methods; D016896:Treatment Outcome