title: NUT Midline Carcinoma of the Nasal Cavity.
abstract: Nuclear protein in testis (NUT) midline carcinoma (NMC) is a rare, aggressive, poorly differentiated form of squamous cell carcinoma caused by a chromosomal rearrangement of the NUT gene on chromosome 15. These tumors have a predilection for midline and paramidline structures of the upper aerodigestive tract and mediastinum and can affect patients across a broad age range, including children. In the current example, a 53 year old male presented with a mass originating in the left nasal cavity. The clinical, radiographic, and morphologic features of NMC are discussed.
authors.affiliation: Navy Medical Center San Diego, 34800 Bob Wilson Dr, San Diego, CA, 92134, USA.
authors.forename: Mia
authors.initials: M
authors.lastname: Edgar
authors.affiliation: Department of Otolaryngology, Walter Reed National Military Medical Center, 8901 Rockville Pike, Bethesda, MD, 20889, USA.
authors.forename: Andria M
authors.initials: AM
authors.lastname: Caruso
authors.affiliation: Department of Otolaryngology, Walter Reed National Military Medical Center, 8901 Rockville Pike, Bethesda, MD, 20889, USA.
authors.forename: Esther
authors.initials: E
authors.lastname: Kim
authors.affiliation: Head and Neck Pathology, Joint Pathology Center, 606 Stephen Sitter Ave., Silver Spring, MD, 20910-1290, USA. robert.d.foss.ctr@mail.mil.
authors.forename: Robert D
authors.initials: RD
authors.lastname: Foss
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009363:Neoplasm Proteins; D009669:Nose Neoplasms / Q000473:pathology*; D009687:Nuclear Proteins / Q000235:genetics; D015513:Oncogene Proteins / Q000235:genetics; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: C000630260:NUTM1 protein, human; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D015513:Oncogene Proteins
keywords: NUT midline carcinoma; Nasal; Nasal cavity; Nuclear protein of testis; Radiology; Sinonasal; Undifferentiated carcinoma