title: Latent tuberculosis infection screening and treatment in HIV: insights from evaluation of UK practice.
abstract: Latent TB infection (LTBI) screening and treatment in HIV-positive individuals in the UK is advocated by the British HIV Association (BHIVA) and National Institute for Health and Care Excellence (NICE), although each recommends differing strategies. We undertook an evaluation of UK practice, relating the responses to the local HIV/TB disease burden. 162 of 188 (86%) UK geographical areas responded; only 93/162 (57.4%) offer LTBI testing with considerable heterogeneity in practice, and no difference in HIV/TB burden between areas offering testing and those who do not. Only 33/93 (35.5%) and 6/93 (6.5%) reported full compliance with BHIVA and NICE guidance respectively. A uniform national guideline is required.
authors.affiliation: Department of Infection and Tropical Medicine, Leicester Royal Infirmary, Leicester, UK.|Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.
authors.forename: Helena A
authors.initials: HA
authors.lastname: White
authors.affiliation: Research Department of Infection and Population Health, University College London, London, UK.
authors.forename: Robert F
authors.initials: RF
authors.lastname: Miller
authors.affiliation: HIV Department, Chelsea and Westminster Hospital, London, UK.
authors.forename: Anton L
authors.initials: AL
authors.lastname: Pozniak
authors.affiliation: UCL Respiratory, Division of Medicine, University College London, London, UK.
authors.forename: Marc C I
authors.initials: MC
authors.lastname: Lipman
authors.affiliation: Department of Infection and Tropical Medicine, Leicester Royal Infirmary, Leicester, UK.
authors.forename: Iain
authors.initials: I
authors.lastname: Stephenson
authors.affiliation: Department of Infection and Tropical Medicine, Leicester Royal Infirmary, Leicester, UK.|Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Wiselka
authors.affiliation: Department of Infection and Tropical Medicine, Leicester Royal Infirmary, Leicester, UK.|Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.
authors.forename: Manish
authors.initials: M
authors.lastname: Pareek
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology; D000328:Adult; D005260:Female; D006801:Humans; D015994:Incidence; D055985:Latent Tuberculosis / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology; D008297:Male; D008403:Mass Screening / Q000379:methods*; D015995:Prevalence; D013222:State Medicine; D006113:United Kingdom / Q000453:epidemiology
keywords: Tuberculosis