title: Non-dividing Cell Virtosomes Affect In Vitro and In Vivo Tumour Cell Replication.
abstract: In vitro studies of partially purified virtosomes from rat liver showed inhibition of cell multiplication in four normal and two tumour cell lines. In vivo, the liver virtosomes slowed tumour growth and limited metastases in rats bearing DHD/K12-PROb cell initiated tumours.
authors.affiliation: Cell Therapy Laboratory, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Avda Reyes Católicos 2, 28040, Madrid, Spain. maga65@gmail.com.|Surgery Department, Medicine School, Universidad Autónoma de Madrid, C/ Arzobispo Morcillo s/n, 28029, Madrid, Spain. maga65@gmail.com.
authors.forename: Mariano
authors.initials: M
authors.lastname: Garcia-Arranz
authors.affiliation: Surgery Department, Medicine School, Universidad Autónoma de Madrid, C/ Arzobispo Morcillo s/n, 28029, Madrid, Spain.|Surgery Department, Fundación Jiménez Díaz, Avda Reyes Católicos 2, 28040, Madrid, Spain.
authors.forename: Damian
authors.initials: D
authors.lastname: Garcia-Olmo
authors.affiliation: Cell Therapy Laboratory, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Avda Reyes Católicos 2, 28040, Madrid, Spain.
authors.forename: Luz
authors.initials: L
authors.lastname: Vega-Clemente
authors.affiliation: , 6 Pedro Meylan, Geneva, 1208, Switzerland.
authors.forename: Maurice
authors.initials: M
authors.lastname: Stroun
authors.affiliation: ICRM, Inserm, Montpellier Cedex, F-34298, France.
authors.forename: Peter B
authors.initials: PB
authors.lastname: Gahan
mesh_terms: D000818:Animals; D002455:Cell Division; D002460:Cell Line; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002478:Cells, Cultured; D022083:Cytoplasmic Structures / Q000378:metabolism* / Q000637:transplantation; D006801:Humans; D008099:Liver / Q000166:cytology / Q000378:metabolism; D008297:Male; D051379:Mice; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D047368:Tumor Burden
keywords: Metastases; Tumour cells; Tumour development; Virtosomes