title: [Association between use of antibacterial agents in the first year of life and childhood asthma: a Meta analysis].
abstract: OBJECTIVE
  To evaluate the association between the use of antibacterial agents in the first years of life and childhood asthma.
  
  
  METHODS
  The Chinese and English databases CNKI, Wanfang Data, VIP, PubMed, and EBSCO were searched for prospective cohort studies on the association between the use of antibacterial agents in the first years of life and childhood asthma. Stata12.0 software was used to analyze the association through a Meta analysis.
  
  
  RESULTS
  The articles with a high quality score and adjusted effective values for factors for lower respiratory tract infection were pooled, and a total of 8 studies were included. The results of the Meta analysis showed that the use of antibacterial agents in the first years of life increased the risk of childhood asthma (OR=1.14, 95%CI: 1.10-1.17, P<0.05). Compared with the children who used antibacterial agents 0-1 times in the first years of life, those who used more than 4 times had an increased risk of asthma (OR=1.28, 95%CI: 1.19-1.38, P<0.05). High-risk children (at least one immediate family member had asthma) who used antibacterial agents had an increased risk of asthma (OR=1.47, 95%CI: 1.20-1.81, P<0.05).
  
  
  CONCLUSIONS
  The use of antibacterial agents in the first years of life increases the risk of childhood asthma. High-risk children who use antibacterial agents have an increased risk of asthma. The increased frequency of use of antibacterial agents in the first years of life is associated with an increased risk of childhood asthma, but the detailed dose relationship needs further investigation.
authors.affiliation: Department of Pharmacy, Children's Hospital of Chongqing Medical University/Ministry of Education Key Laboratory of Child Development and Disorders/China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014, China. 781188140@qq.com.
authors.forename: Meng-Yao
authors.initials: MY
authors.lastname: Xie
authors.forename: Yong-Hua
authors.initials: YH
authors.lastname: Yuan
authors.forename: Li-Mei
authors.initials: LM
authors.lastname: Liu
authors.forename: Rong
authors.initials: R
authors.lastname: Gu
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Zhao
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001249:Asthma / Q000209:etiology*; D049690:History, Ancient; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D012306:Risk
chemical_list: D000900:Anti-Bacterial Agents