title: Evaluation of the Relationships Between Computed Tomography Features, Pathological Findings, and Prognostic Risk Assessment in Gastrointestinal Stromal Tumors.
abstract: OBJECTIVE
  The aim of this study was to correlate computed tomography (CT) findings with pathology in gastrointestinal stromal tumors (GISTs).
  
  
  METHODS
  A retrospective evaluation of CT images of 44 patients with GISTs was performed. Computed tomography findings analyzed were location, size, margins, degree and pattern of contrast enhancement, angiogenesis, necrosis, signs of invasion, peritoneal effusion, peritoneal implants, surface ulceration, and calcifications.Associations between CT features and mitotic rate, Miettinen classes of risk, lesions size, and among CT features were investigated. χ Test and Fisher test were performed.
  
  
  RESULTS
  Mitotic rate was associated with margins (P = 0.016) and with adjacent organ invasion (P = 0.043). Pattern of contrast enhancement (P = 0.002), angiogenesis (P = 0.006), necrosis (P = 0.006), invasion of adjacent organs (P = 0.011), and margins (P = 0.006) were associated with classes of risk. Several associations (P < 0.05) between lesion size and CT features and among all the investigated CT features were found.
  
  
  CONCLUSIONS
  Computed tomography features could reflect GIST biology being associated with the mitotic rate and with classes of risk.
authors.affiliation: From the *Radiology Unit, †Medical and Surgical Sciences and Translation Medicine, ‡Pathology Department, and §Digestive and Liver Disease, Faculty of Medicine and Psychology, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
authors.forename: Elsa
authors.initials: E
authors.lastname: Iannicelli
authors.forename: Francesco
authors.initials: F
authors.lastname: Carbonetti
authors.forename: Giulia Francesca
authors.initials: GF
authors.lastname: Federici
authors.forename: Isabella
authors.initials: I
authors.lastname: Martini
authors.forename: Salvatore
authors.initials: S
authors.lastname: Caterino
authors.forename: Emanuela
authors.initials: E
authors.lastname: Pilozzi
authors.forename: Francesco
authors.initials: F
authors.lastname: Panzuto
authors.forename: Chiara
authors.initials: C
authors.lastname: Briani
authors.forename: Vincenzo
authors.initials: V
authors.lastname: David
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D046152:Gastrointestinal Stromal Tumors / Q000000981:diagnostic imaging* / Q000473:pathology*; D041981:Gastrointestinal Tract / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D014057:Tomography, X-Ray Computed / Q000379:methods*