title: [Indoleamine 2,3-Dioxygenase Activity in Intracystic Breast Tumors].
abstract: We evaluated the clinical significance of indoleamine 2,3-dioxygenase(IDO)in intra-cystic tumors of the breast. IDO activitycan be measured byusing the tryptophan(Trp)/kynurenine(Kyn)ratio. Trp and Kyn were measured by high performance liquid chromatography(HPLC). We took liquid from 3 intra-cystic papilloma cases and 5 intra-cystic breast cancer cases. Then, we measured the Trp/Kyn ratio in these samples, and we evaluated the difference in the Trp/Kyn ratio between the papilloma group and the breast cancer group. The Trp/Kyn ratio was significantly lower in the breast cancer group than in the papilloma group. These results suggest that measuring the Trp/Kyn ratio in cystic liquid from intra-cystic breast lesions is useful to distinguish benign intra-cystic lesions from malignant intra-cystic lesions.
authors.affiliation: Division of Breast and Endocrine Surgery, Dept. of Surgery, Nihon University School of Medicine.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sakurai
authors.forename: Shigeru
authors.initials: S
authors.lastname: Fujisaki
authors.forename: Keita
authors.initials: K
authors.lastname: Adachi
authors.forename: Shuhei
authors.initials: S
authors.lastname: Suzuki
authors.forename: Yuki
authors.initials: Y
authors.lastname: Masuo
authors.forename: Saki
authors.initials: S
authors.lastname: Nagashima
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Hara
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Enomoto
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Hirano
authors.forename: Ryouichi
authors.initials: R
authors.lastname: Tomita
authors.forename: Kenji
authors.initials: K
authors.lastname: Gonda
mesh_terms: D001706:Biopsy; D001943:Breast Neoplasms / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000378:metabolism*; D008875:Middle Aged
chemical_list: D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase