title: Dihydroisocoumarins from the Mangrove-Derived Fungus Penicillium citrinum.
abstract: Three new dihydroisocoumarin penicimarins G-I (1-3), together with one known dihydroisocoumarin (4) and three known meroterpenoids (5-7), were obtained from a fungusPenicillium citrinumisolated from the mangroveBruguiera sexangulavar.rhynchopetalacollected in the South China Sea. Their structures were elucidated by the detailed analysis of spectroscopic data. The absolute configuration of1was determined by the X-ray diffraction analysis using Cu Kα radiation. The absolute configurations of2and3were determined by comparison of their circular dichroism (CD) spectra with the literature. All compounds were evaluated for their antibacterial activities and cytotoxic activities.
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, Hainan, China. huangguolei1982@hainnu.edu.cn.
authors.forename: Guo-Lei
authors.initials: GL
authors.lastname: Huang
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, Hainan, China. xueming2009211@126.com.
authors.forename: Xue-Ming
authors.initials: XM
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, Hainan, China. xxbai2014@163.com.
authors.forename: Meng
authors.initials: M
authors.lastname: Bai
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, Hainan, China. 18174202788@163.com.
authors.forename: Yu-Xin
authors.initials: YX
authors.lastname: Liu
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, Hainan, China. 18689506770@163.com.
authors.forename: Yan-Lei
authors.initials: YL
authors.lastname: Zhao
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, Hainan, China. luoyouping@gmail.com.
authors.forename: You-Ping
authors.initials: YP
authors.lastname: Luo
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, Hainan, China. niuyanyan1986@126.com.
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Niu
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, Hainan, China. caijuan2002@163.com.
authors.forename: Cai-Juan
authors.initials: CJ
authors.lastname: Zheng
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, Hainan, China. chgying123@163.com.
authors.forename: Guang-Ying
authors.initials: GY
authors.lastname: Chen
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D045744:Cell Line, Tumor; D002942:Circular Dichroism; D003374:Coumarins / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000737:chemistry*; D043982:Rhizophoraceae / Q000382:microbiology*; D021241:Spectrometry, Mass, Electrospray Ionization; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D003374:Coumarins
keywords: Penicillium citrinum; antibacterial activity; cytotoxic activity; dihydroisocoumarin; metabolites