title: Macrophages' Choice: Take It In or Keep It Out.
abstract: In tuberculosis, some macrophages in granulomas assume an epitheloid appearance. Using the Mycobacterium marinum-zebrafish model, Cronan et al. (2016) now show that granuloma macrophages undergo reprograming events involving E-cadherin-dependent formation of epithelial-like cell-cell junctions. Interference with the function of E-cadherin in macrophages disorganized the granulomas and protected the fish, introducing new ideas and questions about macrophage function and granulomatous diseases.
authors.affiliation: Department of Microbiology and Immunology, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA. Electronic address: cnathan@med.cornell.edu.
authors.forename: Carl
authors.initials: C
authors.lastname: Nathan
mesh_terms: D000818:Animals; D006801:Humans; D015820:Cadherins / Q000378:metabolism; D006099:Granuloma / Q000378:metabolism / Q000473:pathology; D007365:Intercellular Junctions / Q000378:metabolism / Q000502:physiology; D008264:Macrophages / Q000378:metabolism / Q000502:physiology; D009165:Mycobacterium Infections, Nontuberculous / Q000378:metabolism / Q000473:pathology; D019910:Mycobacterium marinum / Q000472:pathogenicity
chemical_list: D015820:Cadherins