title: The Effect of Osteopontin and an Osteopontin-Derived Synthetic Peptide Coating on Osseointegration of Implants in a Canine Model.
abstract: Osteopontin (OPN) and an OPN-derived synthetic peptide, OC-1016, have demonstrated their potential to enhance osseointegration in vitro. The purpose of this study was to evaluate bone-to-implant contact (BIC) and surrounding bone density (BD) of implants coated with either recombinant human OPN (rhOPN) or OC-1016 as compared with noncoated titanium plasma sprayed (TPS) surface in a canine model. Histomorphometric analysis revealed that at 4 weeks, %BIC and %BD of coated implants were significantly higher than those of noncoated TPS implants. At 12 weeks, %BIC of coated implants was also significantly higher than that of noncoated implants; however, there was no statistically significant difference in %BD. The rhOPN and OC-1016 were concluded to be capable of significantly accelerating the early stage of osseointegration and bone healing around implants.
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Fiorellini
authors.forename: Sven
authors.initials: S
authors.lastname: Glindmann
authors.forename: Jairo
authors.initials: J
authors.lastname: Salcedo
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Weber
authors.forename: Chang-Joo
authors.initials: CJ
authors.lastname: Park
authors.forename: Hector L
authors.initials: HL
authors.lastname: Sarmiento
mesh_terms: D000818:Animals; D015519:Bone Density / Q000187:drug effects; D000069343:Bone-Implant Interface; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D004285:Dogs; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D020007:Implants, Experimental; D008334:Mandible / Q000601:surgery; D008422:Materials Testing; D016348:Osseointegration / Q000187:drug effects*; D053495:Osteopontin / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology*; D013499:Surface Properties; D013524:Surgical Flaps; D014081:Tooth Extraction
chemical_list: D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D010455:Peptides; D053495:Osteopontin