title: The adipose tissue and the involvement of the renin-angiotensin-aldosterone system in cardiometabolic syndrome.
abstract: Cardiometabolic diseases are linked to a cluster of modifiable factors, including risk factors closely related to central adiposity. Chronic renin-angiotensin-aldosterone system (RAAS) activation has far-reaching effects on cardiometabolic risk and is a substantial contributor to this clinical condition. RAAS components are locally expressed in the vessels and adipose tissue. This review appoints RAAS, through the classical and the alternative view, as the main mediator of the cross-talk in cardiometabolic syndrome.
authors.affiliation: LABEEST - Laboratory of Stress Study, Department of Structural and Functional Biology. Institute of Biology, University of Campinas - UNICAMP, CEP: 13083-862, Campinas, SP, Brazil.
authors.forename: F
authors.initials: F
authors.lastname: Borghi
authors.affiliation: Laboratory of Kidney and Hormones, Department of Medicine, Nephrology Division, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Botucatu, 740, CEP: 04023-900, São Paulo, SP, Brazil.
authors.forename: B
authors.initials: B
authors.lastname: Sevá-Pessôa
authors.affiliation: LABEEST - Laboratory of Stress Study, Department of Structural and Functional Biology. Institute of Biology, University of Campinas - UNICAMP, CEP: 13083-862, Campinas, SP, Brazil. doramgk@unicamp.br.
authors.forename: D M
authors.initials: DM
authors.lastname: Grassi-Kassisse
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000450:Aldosterone / Q000378:metabolism*; D000818:Animals; D006801:Humans; D024821:Metabolic Syndrome / Q000378:metabolism*; D012084:Renin-Angiotensin System
chemical_list: D000450:Aldosterone
keywords: Adipose tissue; Adiposity; Angiotensin; Cardiometabolic syndrome; Renin–angiotensin–aldosterone system