title: The histopathologic features of autoimmune progesterone dermatitis.
abstract: BACKGROUND
  The histologic features of autoimmune progesterone dermatitis (APD) are generally non-specific and have been described only in brief case reports. We present a case of APD and review the literature with a focus on the histologic findings described.
  
  
  METHODS
  A review of the English literature on APD was performed using PubMed and MEDLINE.
  
  
  RESULTS
  A total of 39 patients, including our patient are included in this review. The most consistent histologic finding reported was a perivascular inflammatory infiltrate, being seen in 72% of cases. A non-specific or interstitial inflammatory infiltrate was described in 31% of the cases, with 41% having an eosinophilic component and 21% having a neutrophilic component mixed with the predominant lymphocytic infiltrate. Interface dermatitis was the second most common finding with 36% showing a mild to exaggerated interface dermatitis.
  
  
  CONCLUSIONS
  Although histopathologic changes are non-specific, perivascular dermatitis with eosinophils and interface changes are common in APD.
authors.affiliation: Department of Dermatology, St. Joseph Mercy Hospital, Ypsilanti, MI, 48197, USA.
authors.forename: Travis
authors.initials: T
authors.lastname: James
authors.affiliation: Department of Dermatology, St. Joseph Mercy Hospital, Ann Arbor, MI, USA.
authors.forename: Jessica
authors.initials: J
authors.lastname: Ghaferi
authors.affiliation: Department of Dermatology, St. Joseph Mercy Hospital, Ann Arbor, MI, USA.
authors.forename: Ann
authors.initials: A
authors.lastname: LaFond
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases / Q000473:pathology*; D003872:Dermatitis / Q000473:pathology*; D005260:Female; D006801:Humans; D011374:Progesterone / Q000009:adverse effects*
chemical_list: D011374:Progesterone
keywords: autoimmune progesterone dermatitis; histopathology of autoimmune progesterone dermatitis; progesterone allergy; progesterone anaphylaxis