title: The Multifunctional Effects of Nobiletin and Its MetabolitesIn VivoandIn Vitro.
abstract: Nobiletin (NOB) chemically known as 5,6,7,8,3',4'-hexamethoxyflavone is a dietary polymethoxylated flavonoid found inCitrusfruits. Recent evidences show that NOB is a multifunctional pharmaceutical agent. The various pharmacological activities of NOB include neuroprotection, cardiovascular protection, antimetabolic disorder, anticancer, anti-inflammation, and antioxidation. These events may be underpinned by modulation of signaling cascades, including PKA/ERK/MEK/CREB, NF-κB, MAPK, Ca2+/CaMKII, PI3K/Akt1/2, HIF-1α, and TGFβsignaling pathways. The metabolites may exhibit stronger beneficial effects than NOB on diseases pathogenesis. The biological activities of NOB have been clarified on many systems. This review aims to discuss the pharmacological effects of NOB with specific mechanisms of actions. NOB may become a promising candidate for potential drug development. However, further investigations of NOB on specific intracellular targets and clinical trials are still needed, especially forin vivomedical applications.
authors.affiliation: College of Pharmacy, Gannan Medical University, Ganzhou 341000, China.
authors.forename: Hao
authors.identifier: 0000-0002-7788-5519
authors.initials: H
authors.lastname: Huang
authors.affiliation: College of Pharmacy, Gannan Medical University, Ganzhou 341000, China.
authors.forename: Linfu
authors.initials: L
authors.lastname: Li
authors.affiliation: College of Pharmacy, Gannan Medical University, Ganzhou 341000, China.
authors.forename: Weimei
authors.initials: W
authors.lastname: Shi
authors.affiliation: College of Pharmacy, Gannan Medical University, Ganzhou 341000, China.
authors.forename: Hai
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Clinical Research Center, The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China.
authors.forename: Jianqiong
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Respiratory Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China.
authors.forename: Xiaoliang
authors.identifier: 0000-0003-2479-0361
authors.initials: X
authors.lastname: Yuan
authors.affiliation: College of Pharmacy, Gannan Medical University, Ganzhou 341000, China.
authors.forename: Longhuo
authors.identifier: 0000-0002-3899-9599
authors.initials: L
authors.lastname: Wu