title: Spouse with schizophrenia and risk of dementia.
abstract: Increased prevalence of lifestyle risk factors or shared etiology may underlie the association between schizophrenia and the subsequent risk of dementia. We explored the association between having a spouse with schizophrenia and the risk of dementia. We found a positive relationship between having a spouse with schizophrenia and vascular dementia in individuals without a mental disorder themselves but no association between having a spouse with schizophrenia and Alzheimer's dementia. As spouses share environmental risk factors and lifestyle, this might suggest that the excess risk of dementia in probands with schizophrenia could be ascribed to the unhealthy living environment among individuals with schizophrenia.
authors.affiliation: National Centre for Register-Based Research, Aarhus University, Fuglesangs Alle 4, 8210, Aarhus V, Denmark. crohde@econ.au.dk.
authors.forename: Christopher
authors.identifier: 0000-0001-9458-506X
authors.initials: C
authors.lastname: Rohde
authors.affiliation: National Centre for Register-Based Research, Aarhus University, Fuglesangs Alle 4, 8210, Aarhus V, Denmark.|Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.|CIRRAU-Centre for Integrated Register-based Research at Aarhus University, Aarhus, Denmark.
authors.forename: Esben
authors.initials: E
authors.lastname: Agerbo
authors.affiliation: National Centre for Register-Based Research, Aarhus University, Fuglesangs Alle 4, 8210, Aarhus V, Denmark.|Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.
authors.forename: Philip Rising
authors.initials: PR
authors.lastname: Nielsen
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology*; D015140:Dementia, Vascular / Q000453:epidemiology*; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D012042:Registries / Q000706:statistics & numerical data*; D012306:Risk; D012559:Schizophrenia / Q000453:epidemiology*; D018454:Spouses / Q000706:statistics & numerical data*
keywords: Dementia; Disease concordance; Environment; Schizophrenia; Spouse