title: Antipsychotic Induced Symptomatic Hyperprolactinemia: Are Dopamine Agonists Safe?
abstract: Published literature shows that dopamine agonists can reverse antipsychotic-induced hyperprolactinemia without worsening psychotic symptoms in the majority of schizophrenic patients. However, psychiatrists have been reluctant to use drugs with dopaminergic properties for fear of exacerbating psychiatric symptoms. There are reported cases of psychosis worsening published for both cabergoline and bromocriptine. Cabergoline has proven to be more effective and safe when used to treat hyperprolactinemia, but whether cabergoline is also safer than bromocriptine in antipsychotic induced hyperprolactinemia remains unproven.
authors.affiliation: Dr. Lertxundi, Pharmacy Service, Red de Salud Mental de Araba, C/alava 43, Vitoria-Gasteiz, Araba, Spain. Dr. Domingo-Echaburu, Pharmacy Service, Hospital Alto Deba, Avda, Nafarroa, 16, Arrasate Gipuzkoa, Spain. Dr. Peral, Pharmacy Service, Hospital de Galdakao-Usánsolo, Barrio labeaga s/n, Galdakao, VIzcaya, Spain. Dr. García, Basque Country Pharmacovigilance Unit, Galdakao-Usansolo Hospital, Barrio labeaga s/n, Galdakao, VIzcaya, Spain.
authors.forename: Unax
authors.initials: U
authors.lastname: Lertxundi
authors.affiliation: Dr. Lertxundi, Pharmacy Service, Red de Salud Mental de Araba, C/alava 43, Vitoria-Gasteiz, Araba, Spain. Dr. Domingo-Echaburu, Pharmacy Service, Hospital Alto Deba, Avda, Nafarroa, 16, Arrasate Gipuzkoa, Spain. Dr. Peral, Pharmacy Service, Hospital de Galdakao-Usánsolo, Barrio labeaga s/n, Galdakao, VIzcaya, Spain. Dr. García, Basque Country Pharmacovigilance Unit, Galdakao-Usansolo Hospital, Barrio labeaga s/n, Galdakao, VIzcaya, Spain.
authors.forename: Saioa
authors.initials: S
authors.lastname: Domingo-Echaburu
authors.affiliation: Dr. Lertxundi, Pharmacy Service, Red de Salud Mental de Araba, C/alava 43, Vitoria-Gasteiz, Araba, Spain. Dr. Domingo-Echaburu, Pharmacy Service, Hospital Alto Deba, Avda, Nafarroa, 16, Arrasate Gipuzkoa, Spain. Dr. Peral, Pharmacy Service, Hospital de Galdakao-Usánsolo, Barrio labeaga s/n, Galdakao, VIzcaya, Spain. Dr. García, Basque Country Pharmacovigilance Unit, Galdakao-Usansolo Hospital, Barrio labeaga s/n, Galdakao, VIzcaya, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Peral
authors.affiliation: Dr. Lertxundi, Pharmacy Service, Red de Salud Mental de Araba, C/alava 43, Vitoria-Gasteiz, Araba, Spain. Dr. Domingo-Echaburu, Pharmacy Service, Hospital Alto Deba, Avda, Nafarroa, 16, Arrasate Gipuzkoa, Spain. Dr. Peral, Pharmacy Service, Hospital de Galdakao-Usánsolo, Barrio labeaga s/n, Galdakao, VIzcaya, Spain. Dr. García, Basque Country Pharmacovigilance Unit, Galdakao-Usansolo Hospital, Barrio labeaga s/n, Galdakao, VIzcaya, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: García
keywords: Antipsychotic; Bromocriptine; Cabergoline; Hyperprolactinemia; Pharmacovigilance