title: Clinical effectiveness of a pylorus-preserving procedure on total pancreatectomy with islet autotransplantation.
abstract: BACKGROUND
  The impact of pylorus preserving procedures (PP) on total pancreatectomy with islet autotransplantation (TPIAT) has not been examined. This study aimed to investigate the clinical impact of the PP on TPIAT.
  
  
  METHODS
  The Baylor Simmons Transplant Institute database was queried to identify seventy-three patients who underwent TPIAT from 2006 to 2014. All patients were investigated in postoperative complications, long-term nutritional status, and graft function.
  
  
  RESULTS
  Patients with PP did not face worse outcomes in terms of delayed gastric emptying and length of hospital stay. Also, nutritional status and metabolic outcome, such as body weight, serum albumin level, serum vitamin level, HbA1c level, graft survival rate and insulin independent rate, were similar between both groups.
  
  
  CONCLUSIONS
  Clinical results including the graft function indicated that patients undergoing TPIAT with PP did not amplify surgical complications such as delayed gastric emptying and showed no significant advantage of nutrition and metabolic outcome.
authors.affiliation: Department of Surgery, University of Virginia, Charlottesville, VA, USA.
authors.forename: Rauf
authors.initials: R
authors.lastname: Shahbazov
authors.affiliation: Islet Cell Laboratory, Baylor Research Institute, Dallas, TX, USA.
authors.forename: Gumpei
authors.initials: G
authors.lastname: Yoshimatsu
authors.affiliation: Islet Cell Laboratory, Baylor Research Institute, Dallas, TX, USA.
authors.forename: Waqas Z
authors.initials: WZ
authors.lastname: Haque
authors.affiliation: Islet Cell Laboratory, Baylor Research Institute, Dallas, TX, USA.
authors.forename: Omar S
authors.initials: OS
authors.lastname: Khan
authors.affiliation: Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX, USA.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Saracino
authors.affiliation: Islet Cell Laboratory, Baylor Research Institute, Dallas, TX, USA.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Lawrence
authors.affiliation: Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX, USA.
authors.forename: Peter T
authors.initials: PT
authors.lastname: Kim
authors.affiliation: Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX, USA.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Onaca
authors.affiliation: Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX, USA. Electronic address: Bashoo.Naziruddin@BSWHealth.org.
authors.forename: Bashoo
authors.initials: B
authors.lastname: Naziruddin
authors.affiliation: Transplant Division, Department of Surgery, Virginia Commonwealth University Medical Center, Richmond, VA, USA.
authors.forename: Marlon F
authors.initials: MF
authors.lastname: Levy
mesh_terms: D000328:Adult; D005260:Female; D006085:Graft Survival; D006801:Humans; D016381:Islets of Langerhans Transplantation; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D010180:Pancreatectomy; D050500:Pancreatitis, Chronic / Q000601:surgery*; D011708:Pylorus; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: Chronic pancreatitis; Islet autotransplantation; Pylorus preservation; Total pancreatectomy