title: Monochlorinated calocerins A-D and 9-oxostrobilurin derivatives from the basidiomycete Favolaschia calocera.
abstract: Eight previously undescribed compounds were isolated and characterised from the supernatant and mycelium of a culture of the basidiomycete Favolaschia calocera originating from Kakamega equatorial rainforest in Kenya. These were: 9- oxostrobilurins A, G, K and I and the four monochlorinated calocerins A, B, C and D. The calocerins extend our knowledge of halogenated compounds obtained from natural sources. Four further known compounds were also identified: strobilurin G, favolon, pterulinic acid and 2,3 -dihydro-1-benzoxepin derivative. The four oxostrobilurins exhibited prominent antifungal and cytotoxic activities while the four calocerins only showed cytotoxic activity.
authors.affiliation: Helmholtz Centre for Infection Research GmbH (HZI), Department Microbial Drugs, Inhoffenstraße 7, 38124, Braunschweig, Germany.
authors.forename: Clara
authors.initials: C
authors.lastname: Chepkirui
authors.affiliation: Helmholtz Centre for Infection Research GmbH (HZI), Department Microbial Drugs, Inhoffenstraße 7, 38124, Braunschweig, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Richter
authors.affiliation: Egerton University, Department of Chemistry, P.O Box 536, 20115, Njoro, Kenya.
authors.forename: Josphat Clement
authors.initials: JC
authors.lastname: Matasyoh
authors.affiliation: Helmholtz Centre for Infection Research GmbH (HZI), Department Microbial Drugs, Inhoffenstraße 7, 38124, Braunschweig, Germany. Electronic address: marc.stadler@helmholtz-hzi.de.
authors.forename: Marc
authors.initials: M
authors.lastname: Stadler
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001487:Basidiomycota / Q000737:chemistry*; D001572:Benzofurans / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007630:Kenya; D008689:Methacrylates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010082:Oxepins / Q000737:chemistry; D000073739:Strobilurins; D014315:Triterpenes / Q000737:chemistry
chemical_list: D000935:Antifungal Agents; D001572:Benzofurans; D005231:Fatty Acids, Unsaturated; D006843:Hydrocarbons, Chlorinated; D008689:Methacrylates; D010082:Oxepins; D000073739:Strobilurins; D014315:Triterpenes; C095350:favolon; C106751:pterulinic acid; C065217:strobilurin G
keywords: Antifungal activity; Calocerin; Cytotoxicity; Favolaschia calocera; Mycenaceae; Strobilurins; Structure elucidation