title: Ageing in the musculoskeletal system.
abstract: The extent of ageing in the musculoskeletal system during the life course affects the quality and length of life. Loss of bone, degraded articular cartilage, and degenerate, narrowed intervertebral discs are primary features of an ageing skeleton, and together they contribute to pain and loss of mobility. This review covers the cellular constituents that make up some key components of the musculoskeletal system and summarizes discussion from the 2015 Aarhus Regenerative Orthopaedic Symposium (AROS) (Regeneration in the Ageing Population) about how each particular cell type alters within the ageing skeletal microenvironment.
authors.affiliation: a Spinal Studies and ISTM , Keele University, and Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust , Oswestry , UK.
authors.forename: Sally
authors.initials: S
authors.lastname: Roberts
authors.affiliation: b INSERM U791-LIOAD , Centre Hospitalo-Universitaire (CHU) de Nantes , Nantes , France.
authors.forename: Pauline
authors.initials: P
authors.lastname: Colombier
authors.affiliation: c Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences , University of Oxford , Oxford , UK.
authors.forename: Aneka
authors.initials: A
authors.lastname: Sowman
authors.affiliation: a Spinal Studies and ISTM , Keele University, and Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust , Oswestry , UK.
authors.forename: Claire
authors.initials: C
authors.lastname: Mennan
authors.affiliation: d Orthopaedic Research Laboratory and Departments of Orthopaedics , Aarhus and Aalborg University Hospitals , Aarhus , Denmark.
authors.forename: Jan H D
authors.initials: JH
authors.lastname: Rölfing
authors.affiliation: b INSERM U791-LIOAD , Centre Hospitalo-Universitaire (CHU) de Nantes , Nantes , France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Guicheux
authors.affiliation: c Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences , University of Oxford , Oxford , UK.
authors.forename: James R
authors.initials: JR
authors.lastname: Edwards
mesh_terms: D000375:Aging / Q000473:pathology / Q000502:physiology*; D001842:Bone and Bones / Q000473:pathology / Q000503:physiopathology; D002358:Cartilage, Articular / Q000473:pathology / Q000503:physiopathology; D016922:Cellular Senescence / Q000502:physiology; D019902:Chondrocytes / Q000502:physiology; D006801:Humans; D007403:Intervertebral Disc / Q000473:pathology / Q000503:physiopathology; D009141:Musculoskeletal System / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology*