title: Oligodeoxynucleotide Analogues of Circulating DNA Inhibit dsRNA-Induced Immune Response at the Early Stages of Signal Transduction Cascade in a Cell Type-Dependent Manner.
abstract: Oligodeoxynucleotide (ODN) analogues of cell-surface-bound circulating DNA inhibit the dsRNA-induced production of pro-inflammatory interleukin 6, interferon beta and antibacterial peptide beta-defensin 2 not only in human gingival fibroblasts, but also in human primary endothelial and transformed cells (Hela and A431). ODN analogues do not effect dendritic cells activation by poly(I:C). The data obtained indicate that the early stages of the signal transduction cascade are violated by ODN analogues and the effects depend on the cell type.
authors.affiliation: Institute of Chemical Biology and FundamentalMedicine SB RAS, Lavrentiev ave., 8, Novosibirsk, 630090, Russia. a_cher@niboch.nsc.ru.
authors.forename: Anna V
authors.initials: AV
authors.lastname: Cherepanova
authors.affiliation: Institute of Chemical Biology and FundamentalMedicine SB RAS, Lavrentiev ave., 8, Novosibirsk, 630090, Russia.
authors.forename: Zhanna K
authors.initials: ZK
authors.lastname: Nazarkina
authors.affiliation: Institute of Chemical Biology and FundamentalMedicine SB RAS, Lavrentiev ave., 8, Novosibirsk, 630090, Russia.
authors.forename: Pavel P
authors.initials: PP
authors.lastname: Laktionov
mesh_terms: D002478:Cells, Cultured; D004247:DNA / Q000097:blood / Q000235:genetics*; D006367:HeLa Cells; D006801:Humans; D009838:Oligodeoxyribonucleotides / Q000235:genetics*; D012330:RNA, Double-Stranded / Q000235:genetics* / Q000276:immunology; D015398:Signal Transduction / Q000235:genetics* / Q000276:immunology
chemical_list: D009838:Oligodeoxyribonucleotides; D012330:RNA, Double-Stranded; D004247:DNA
keywords: Circulating DNA; Double-stranded RNA; Innate immunity; Interferon; Interleukin