title: Precision medicine in pediatric oncology: Lessons learned and next steps.
abstract: The maturation of genomic technologies has enabled new discoveries in disease pathogenesis as well as new approaches to patient care. In pediatric oncology, patients may now receive individualized genomic analysis to identify molecular aberrations of relevance for diagnosis and/or treatment. In this context, several recent clinical studies have begun to explore the feasibility and utility of genomics-driven precision medicine. Here, we review the major developments in this field, discuss current limitations, and explore aspects of the clinical implementation of precision medicine, which lack consensus. Lastly, we discuss ongoing scientific efforts in this arena, which may yield future clinical applications.
authors.affiliation: Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan.|Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan.
authors.forename: Rajen J
authors.initials: RJ
authors.lastname: Mody
authors.affiliation: Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.
authors.forename: John R
authors.initials: JR
authors.lastname: Prensner
authors.affiliation: Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan.|Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan.
authors.forename: Jessica
authors.initials: J
authors.lastname: Everett
authors.affiliation: Department of Pediatrics, Baylor College of Medicine, Houston, Texas.|Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas.
authors.forename: D Williams
authors.initials: DW
authors.lastname: Parsons
authors.affiliation: Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan.|Department of Pathology and Michigan Center for Translational Pathology (MCTP), University of Michigan Medical School, Ann Arbor, Michigan.|Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, Michigan.
authors.forename: Arul M
authors.initials: AM
authors.lastname: Chinnaiyan
mesh_terms: D035843:Biomedical Research; D023281:Genomics; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000628:therapy*; D057285:Precision Medicine
keywords: next-generation sequencing; oncology; precision medicine; targeted therapy