title: Redox enzyme-mimicking activities of CeO2nanostructures: Intrinsic influence of exposed facets.
abstract: CeO2nanoparticles (NPs) have been well demonstrated as an antioxidant in protecting against oxidative stress-induced cellular damages and a potential therapeutic agent for various diseases thanks to their redox enzyme-mimicking activities. The Ce3+/Ce4+ratio and oxygen vacancies on the surface have been considered as the major originations responsible for the redox enzyme-mimicking activities of CeO2NPs. Herein, CeO2nanostructures (nanocubes and nanorods) exposed different facets were synthesized via a facile hydrothermal method. The characterizations by X-ray photoelectron spectroscopy, Raman spectroscopy, and UV-Vis spectroscopy show that the Ce3+/Ce4+ratio and oxygen vacancy content on the surfaces of as-synthesized CeO2nanostructures are nearly at the same levels. Meanwhile, the enzymatic activity measurements indicate that the redox enzyme-mimicking activities of as-synthesized CeO2nanostructures are greatly dependent on their exposed facets. CeO2nanocubes with exposed {100} facets exhibit a higher peroxidase but lower superoxide dismutase activity than those of the CeO2nanorods with exposed {110} facets. Our results provide new insights into the redox enzyme-mimicking activities of CeO2nanostructures, as well as the design and synthesis of inorganic nanomaterials-based artificial enzymes.
authors.affiliation: State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, and Biomedical Material and Engineering Center, Wuhan University of Technology, Wuhan 430070, China.
authors.forename: Yushi
authors.initials: Y
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, and Biomedical Material and Engineering Center, Wuhan University of Technology, Wuhan 430070, China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Mao
authors.affiliation: State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, and Biomedical Material and Engineering Center, Wuhan University of Technology, Wuhan 430070, China.
authors.forename: Wenjie
authors.initials: W
authors.lastname: Huang
authors.affiliation: State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, and Biomedical Material and Engineering Center, Wuhan University of Technology, Wuhan 430070, China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Liu
authors.affiliation: School of Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan 430070, China.
authors.forename: Junli
authors.initials: J
authors.lastname: Li
authors.affiliation: School of Chemical Engineering, Shangdong University of Technology, Zibo 255000, China.
authors.forename: Jialiang
authors.initials: J
authors.lastname: Li
authors.affiliation: State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, and Biomedical Material and Engineering Center, Wuhan University of Technology, Wuhan 430070, China.
authors.forename: Qingzhi
authors.initials: Q
authors.lastname: Wu
mesh_terms: D000975:Antioxidants / Q000737:chemistry; D002563:Cerium / Q000737:chemistry*; D007477:Ions; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D043942:Nanotubes / Q000737:chemistry; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry; D009195:Peroxidase / Q000737:chemistry; D056951:Photoelectron Spectroscopy; D013056:Spectrophotometry, Ultraviolet; D013059:Spectrum Analysis, Raman; D013482:Superoxide Dismutase / Q000737:chemistry; D014466:Ultraviolet Rays; D014961:X-Ray Diffraction
chemical_list: D000975:Antioxidants; D007477:Ions; D002563:Cerium; C030583:ceric oxide; D009195:Peroxidase; D013482:Superoxide Dismutase; D010100:Oxygen