title: Norovirus genetic diversity and evolution: implications for antiviral therapy.
abstract: Human noroviruses are the leading cause of foodborne illness causing both acute and chronic gastroenteritis. In recent years, a number of vaccine candidates entered (pre-) clinical development and the first efforts to develop antiviral therapy have been made. We here discuss aspects of norovirus genetic evolution, persistence in immunocompromised patients as well as the risk and potential consequences of resistance development toward future antiviral drugs.
authors.affiliation: KU Leuven - University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
authors.forename: Joana
authors.initials: J
authors.lastname: Rocha-Pereira
authors.affiliation: KU Leuven - University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
authors.forename: Jana
authors.initials: J
authors.lastname: Van Dycke
authors.affiliation: KU Leuven - University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium. Electronic address: Johan.Neyts@kuleuven.be.Rega.
authors.forename: Johan
authors.initials: J
authors.lastname: Neyts
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D017250:Caliciviridae Infections / Q000821:virology*; D024882:Drug Resistance, Viral; D005517:Foodborne Diseases / Q000821:virology; D005759:Gastroenteritis / Q000821:virology; D014644:Genetic Variation; D006801:Humans; D029322:Norovirus / Q000145:classification* / Q000187:drug effects / Q000235:genetics*
chemical_list: D000998:Antiviral Agents