title: Poor Prognosis in Acute Myeloid Leukemia Patients with Monosomal Karyotypes.
abstract: OBJECTIVE
  This study aimed to investigate the clinical characteristics and prognostic significance of monosomal karyotypes (MKs) in patients with acute myeloid leukemia (AML).
  
  
  METHODS
  We retrospectively analyzed the clinical data for 498 patients with AML, of whom 233 (46.8%) had an abnormal karyotype, including 42 with MKs (8.4%) and 70 with a complex karyotype (CK) (14.1%).
  
  
  RESULTS
  Patients with MKs were older (median age 62.5 vs. 52 years, p=0.003) and had lower median hemoglobin levels (62.5 vs. 77 g/L, p=0.009) and lower white blood cell counts (7.0×109/L vs. 11.7×109/L, p=0.008). Univariate analysis showed that patients with MKs or CKs had shorter overall survival than patients without these karyotypes (median survival time 7.3 vs. 26.3 months for MK, p<0.001, and 14.8 vs. 26.3 months for CK, p<0.001). In multivariable analysis for overall survival, MK and National Comprehensive Cancer Network prognostic group were the only significant factors.
  
  
  CONCLUSIONS
  MK is an independent risk factor for poor prognosis in AML patients.
authors.forename: Junqing
authors.initials: J
authors.lastname: Xu
authors.forename: Baohua
authors.initials: B
authors.lastname: Huang
authors.forename: Xiaoqian
authors.initials: X
authors.lastname: Liu
authors.forename: Yuanfeng
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yinghui
authors.initials: Y
authors.lastname: Liu
authors.forename: Liming
authors.initials: L
authors.lastname: Chen
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Luan
authors.forename: Nannan
authors.initials: N
authors.lastname: Li
authors.affiliation: Qindao University Medical College, Affiliated Yantai Yuhuangding Hospital, Department of Hematology, Yantai, China Phone: +86-535-6691999-82303 E-mail: xiaoxiachu66@126.com.
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Chu
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002872:Chromosome Deletion; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D015996:Survival Rate