title: Mechanisms of activation and inhibition of Zika virus NS2B-NS3 protease.
authors.affiliation: School of Life Sciences, Tianjin University, Tianjin 300072, China.|Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Chen
authors.affiliation: Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA.
authors.forename: Kailin
authors.initials: K
authors.lastname: Yang
authors.affiliation: School of Life Sciences, Tianjin University, Tianjin 300072, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Wu
authors.affiliation: School of Life Sciences, Tianjin University, Tianjin 300072, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Chen
authors.affiliation: School of Life Sciences, Tianjin University, Tianjin 300072, China.|Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China.
authors.forename: Can
authors.initials: C
authors.lastname: Hu
authors.affiliation: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
authors.forename: Olga
authors.initials: O
authors.lastname: Buzovetsky
authors.affiliation: School of Life Sciences, Tianjin University, Tianjin 300072, China.
authors.forename: Zefang
authors.initials: Z
authors.lastname: Wang
authors.affiliation: The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu 210023, China.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Ji
authors.affiliation: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
authors.forename: Yong
authors.initials: Y
authors.lastname: Xiong
authors.affiliation: School of Life Sciences, Tianjin University, Tianjin 300072, China.|Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Yang
mesh_terms: D018360:Crystallography, X-Ray; D010450:Endopeptidases / Q000378:metabolism*; D004789:Enzyme Activation; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D000071244:Zika Virus / Q000201:enzymology*
chemical_list: D017361:Viral Nonstructural Proteins; D010450:Endopeptidases