title: Evaluation of soluble human leukocyte antigen-G in peripheral blood of pregnant women with gestational diabetes mellitus.
abstract: BACKGROUND
  Research says that diabetes may develop in over 10% of non-diabetic pregnant women. Diabetes which generally occurs late in second trimester and third trimester of pregnancy, it is called gestational diabetes. Overweight or suffering from obesity before pregnancy is type 2 diabetes risk factor. In most cases, diabetic symptoms disappear after delivery. HLA-G has an important role both in mother and fetus tolerance during pregnancy, it may also be effective in the protection of pancreatic islet cells. In this study, concentration of these molecules in pregnant women with gestational diabetes in comparison with normal pregnant women was investigated.
  
  
  METHODS
  In this case-control study, we measured serum HLA-G levels in 24 pregnant women with gestational diabetes compared with 30 normal pregnant women using sandwich ELISA.
  
  
  RESULTS
  HLA-G levels were significantly low in pregnant women with gestational diabetes in contrast to normal pregnant women (P=0.001).
  
  
  CONCLUSIONS
  In this study, we found that HLA-G levels were reduced in women with gestational diabetes compared with control group. Therefore, it is suggested that measurement of HLA-G in pregnant women can be considered as an indicator in prognosis of gestational diabetes.
authors.affiliation: Student Research Committee, Mazandaran University of Medical Sciences, sari, Iran; Immunogenetic Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Saeide-Sadat
authors.initials: SS
authors.lastname: Shobeiri
authors.affiliation: Immunogenetic Research Center, Mazandaran University of Medical Sciences, Sari, Iran; Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Saeid
authors.initials: S
authors.lastname: Abediankenari
authors.affiliation: Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Bahareh
authors.initials: B
authors.lastname: Lashtoo-Aghaee
authors.affiliation: Immunogenetic Research Center, Mazandaran University of Medical Sciences, Sari, Iran; Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Rahmani
authors.affiliation: Department of Biology, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran.
authors.forename: Bahareh
authors.initials: B
authors.lastname: Esmaeili-Gorji
keywords: HLA-G; gestational diabetes; pregnancy