title: pH-Switchable vitamin B9gels for stoichiometry-controlled spherical co-crystallization.
abstract: Vitamin B9gels were found to be pH-switchable by adding triethylamine or acetic acid. Such recyclable gels can be used as novel co-crystallization media, resulting in four stoichiometric vitamin C co-crystals. Under highly supersaturated conditions, uniform microspheres of (VC)·(NA) with different particle sizes were obtained through a spherical crystallization process.
authors.affiliation: Pharmaceutical Analytical & Solid-State Chemistry Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. xuefengmei@simm.ac.cn.
authors.forename: Jian-Rong
authors.initials: JR
authors.lastname: Wang
authors.affiliation: Pharmaceutical Analytical & Solid-State Chemistry Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. xuefengmei@simm.ac.cn.
authors.forename: Junjie
authors.initials: J
authors.lastname: Bao
authors.affiliation: Pharmaceutical Analytical & Solid-State Chemistry Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. xuefengmei@simm.ac.cn.
authors.forename: Xiaowu
authors.initials: X
authors.lastname: Fan
authors.affiliation: Pharmaceutical Analytical & Solid-State Chemistry Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. xuefengmei@simm.ac.cn.
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Dai
authors.affiliation: Pharmaceutical Analytical & Solid-State Chemistry Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. xuefengmei@simm.ac.cn.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Mei