title: IL-17: overview and role in oral immunity and microbiome.
abstract: Interleukin-17 (IL-17) is a multifaceted cytokine with diverse roles in both immune protection and also immunopathology. IL-17 has a well-recognized role in immune surveillance at mucosal and barrier surfaces, but also has been increasingly implicated as a driver of immunopathology in settings of autoimmunity and chronic inflammation. The current review introduces basic aspects of IL-17 biology and examines the protective and pathogenic roles of IL-17 with a focus on oral mucosal immunity and inflammation. Specific emphasis is given to the role of the IL-17 response as a catalyst in 'shaping the microbiome at the oral barrier'.
authors.affiliation: Oral Immunity and Inflammation Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
authors.forename: L
authors.initials: L
authors.lastname: Abusleme
authors.affiliation: Oral Immunity and Inflammation Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
authors.forename: N M
authors.initials: NM
authors.lastname: Moutsopoulos
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism; D006801:Humans; D018928:Immunity, Mucosal; D020381:Interleukin-17 / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D064307:Microbiota; D009061:Mouth Mucosa / Q000276:immunology* / Q000382:microbiology; D010518:Periodontitis / Q000276:immunology / Q000378:metabolism*; D053722:Receptors, Interleukin-17 / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
chemical_list: C109985:IL17RA protein, human; D020381:Interleukin-17; D053722:Receptors, Interleukin-17
keywords: IL-17; Th17; oral microbiome; oral mucosal immunity