title: [The use of L-lysine aescinat in the treatment of microcirculatory disturbances in patients young and middle age with violation of the intracranial venous outflow].
abstract: OBJECTIVE
  To study the efficacy of L-lysine aescinat in the treatment of vascular and microvascular disorders in patients with cerebral venous dystonia.
  
  
  METHODS
  Sixty-eight patients, 25 male and 43 female, aged from 25 to 56 years, with disturbances of venous cerebral blood circulation and venous outflow difficulties were examined. The examination included the assessment of cerebral hemodynamics using the algorithm of complex ultrasound examinations and functional status of the microcirculation by the laser Doppler flowmetry (LDF) at baseline and 10 days after treatment with L-lysine aescinat.
  
  
  CONCLUSIONS
  L-lysine aescinat improves intracranial venous outflow, significantly improves the functioning of microcirculation, while not affecting the normal type of microcirculation or changing it in the direction of improvement of hemodynamic parameters, has a modulating effect on the autonomic response, and can be recommended in the complex treatment of young and middle aged patients with disturbances of cerebral venous blood circulation with the predominance of vagotonia as well as hypersympathicotonia.
authors.affiliation: Ivanovo State Medical Academy, Ivanovo, Russia.
authors.forename: E N
authors.initials: EN
authors.lastname: D'iakonova
authors.affiliation: National Research Medical University, Moscow, Russia Co 'Arterium', Moscow, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Fedin
authors.affiliation: Ivanovo State Medical Academy, Ivanovo, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Makerova
authors.affiliation: National Research Medical University, Moscow, Russia Co 'Arterium', Moscow, Russia.
authors.forename: V N
authors.initials: VN
authors.lastname: Gorbunov
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging; D059345:Cerebral Small Vessel Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002550:Cerebral Veins / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008239:Lysine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008833:Microcirculation / Q000187:drug effects*; D008875:Middle Aged; D014463:Ultrasonography
chemical_list: D008239:Lysine