title: Early development of the Drosophila mushroom bodies, brain centres for associative learning and memory.
abstract: We have studied the formation of Drosophila mushroom bodies using enhancer detector techniques to visualize specific components of these complex intrinsic brain structures. During embryogenesis, neuronal proliferation begins in four mushroom body neuroblasts and the major axonal pathways of the mushroom bodies are pioneered. During larval development, neuronal proliferation continues and further axonal projections in the pedunculus and lobes are formed in a highly structured manner characterized by spatial heterogeneity of reporter gene expression. Enhancer detector analysis identifies many genomic locations that are specifically activated in mushroom body intrinsic neurons (Kenyon cells) during the transition from embryonic to postembryonic development and during metamorphosis.
authors.affiliation: Institute of Zoology, University of Basel, CH-4051 Basel, Switzerland, , , , , , CH.
authors.forename: Marco
authors.initials: M
authors.lastname: Tettamanti
authors.affiliation: Division of Molecular Genetics, University of Glasgow, Glasgow G11 6NU, UK, , , , , , GB.
authors.forename: J Douglas
authors.initials: JD
authors.lastname: Armstrong
authors.affiliation: Institute of Biological Sciences, Tsukuba University, Tsukuba 305, Japan, , , , , , JP.
authors.forename: Keita
authors.initials: K
authors.lastname: Endo
authors.affiliation: Division of Molecular Genetics, University of Glasgow, Glasgow G11 6NU, UK, , , , , , GB.
authors.forename: Ming Yao
authors.initials: MY
authors.lastname: Yang
authors.affiliation: Institute of Biological Sciences, Tsukuba University, Tsukuba 305, Japan, , , , , , JP.
authors.forename: Katsuo
authors.initials: K
authors.lastname: Furukubo-Tokunaga
authors.affiliation: Division of Molecular Genetics, University of Glasgow, Glasgow G11 6NU, UK, , , , , , GB.
authors.forename: K
authors.initials: K
authors.lastname: Kaiser
authors.affiliation: Institute of Zoology, University of Basel, CH-4051 Basel, Switzerland, , , , , , CH.
authors.forename: H
authors.initials: H
authors.lastname: Reichert
keywords: Drosophila; Enhancer-trap; GAL4; Kenyon cells; Key words Mushroom bodies