title: More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor?
abstract: It is widely accepted that the glucocorticoid receptor (GR), a ligand-regulated transcription factor that triggers anti-inflammatory responses, binds specific response elements as a homodimer. Here, we will discuss the original primary data that established this model and contrast it with a recent report characterizing the GR-DNA complex as a tetramer.
authors.affiliation: a Laboratory of Receptor Biology and Gene Expression , National Cancer Institute, National Institutes of Health , Bethesda , MD , USA.
authors.forename: Diego M
authors.initials: DM
authors.lastname: Presman
authors.affiliation: a Laboratory of Receptor Biology and Gene Expression , National Cancer Institute, National Institutes of Health , Bethesda , MD , USA.
authors.forename: Gordon L
authors.initials: GL
authors.lastname: Hager
mesh_terms: D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D008957:Models, Genetic; D008958:Models, Molecular; D020836:Protein Structure, Quaternary; D011965:Receptors, Glucocorticoid / Q000737:chemistry* / Q000378:metabolism*; D020218:Response Elements
chemical_list: D011965:Receptors, Glucocorticoid; D004247:DNA
keywords: DNA binding; dimer; glucocorticoid receptor; monomer; steroid receptors; tetramer