title: Significance of Size of Persistent/Recurrent Central Nodal Disease on Surgical Morbidity and Response to Therapy in Reoperative Neck Dissection for Papillary Thyroid Carcinoma.
abstract: To balance the risk of disease progression, morbidity, and efficacy of reoperative central neck dissection (RCND) in papillary thyroid carcinoma, the latest clinical guidelines recommend early surgery over surveillance when the largest diseased node is >8 mm in its smallest dimension. However, the evidence remains scarce. To determine an appropriate size for first-time RCND, the relationship between size of largest diseased central node, morbidity, and response-to-therapy following RCND was examined.
  
  
  
  A total of 130 patients who underwent RCND following initial surgery for persistent/recurrent nodal disease were reviewed. Patients with largest diseased central node measured preoperatively by ultrasonography were included. Eligible patients were categorized into three groups: largest central node <10 mm (group I), 10-15 mm (group II), and >15 mm (group III). Surgical morbidity and response to therapy at one year after RCND were compared between groups. To evaluate biochemical response, patients with structural incompleteness were excluded.
  
  
  
  Group III not only had significantly more high-risk tumors (by American Thyroid Association risk stratification) at initial therapy (64.5% vs. 44.4%, respectively; p = 0.038), but this group also a higher risk of extranodal extension (35.5% vs. 16.0%; p = 0.055), recurrent laryngeal nerve involvement (19.4% vs. 0.0%; p < 0.001), incomplete surgical resection (48.4% vs. 7.4%; p < 0.001), new-onset vocal cord paresis (16.7% vs. 2.5%; p = 0.017), overall surgical morbidity (22.6% vs. 7.4%; p = 0.021), and biochemical incompleteness (80.6% vs. 67.9%; p = 0.004) than groups I and II combined did. However, overall morbidity did not differ between groups I and II (5.7% vs. 8.7%; p = 0.694). After adjusting for American Thyroid Association risk stratification, only the size of the largest diseased central node ≥15 mm (odds ratio = 7.256 [confidence interval 1.302-40.434], p = 0.001) was an independent risk factor for biochemical incompleteness following RCND.
  
  
  
  Patients with larger diseased central node(s) had a significantly higher risk of local invasion, surgical morbidity, and biochemical incompleteness. Relative to nodal size <10 mm, size >15 mm in the largest disease central node was an independent risk factor for incomplete biochemical response, while nodal size 10-15 mm was not. These findings imply that the recommended threshold of 8 mm might be too stringent and could be raised to 15 mm without increasing the surgical morbidity from RCND.
authors.affiliation: 1 Department of Surgery, The University of Hong Kong , Hong Kong SAR, China .
authors.forename: Brian Hung-Hin
authors.initials: BH
authors.lastname: Lang
authors.affiliation: 2 Department of Anatomical Pathology, The University of Hong Kong , Hong Kong SAR, China .
authors.forename: Tony W H
authors.initials: TW
authors.lastname: Shek
authors.affiliation: 3 Division of Clinical Biochemistry, Department of Pathology and Clinical Biochemistry, Queen Mary Hospital , Hong Kong SAR, China .
authors.forename: Angel On-Kei
authors.initials: AO
authors.lastname: Chan
authors.affiliation: 1 Department of Surgery, The University of Hong Kong , Hong Kong SAR, China .
authors.forename: Chung-Yau
authors.initials: CY
authors.lastname: Lo
authors.affiliation: 4 Department of Clinical Oncology, The University of Hong Kong , Hong Kong SAR, China .
authors.forename: Koon Yat
authors.initials: KY
authors.lastname: Wan
mesh_terms: D000328:Adult; D000368:Aged; D002291:Carcinoma, Papillary / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000601:surgery; D011379:Prognosis; D012086:Reoperation; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000601:surgery
keywords: ATA risk stratification; central neck dissection; disease recurrence; disease-free survival; reoperation; response to therapy