title: Rodent Gymnastics: Neurobehavioral Assays in Ischemic Stroke.
abstract: Despite years of research, most preclinical trials on ischemic stroke have remained unsuccessful owing to poor methodological and statistical standards leading to "translational roadblocks." Various behavioral tests have been established to evaluate traits such as sensorimotor function, cognitive and social interactions, and anxiety-like and depression-like behavior. A test's validity is of cardinal importance as it influences the chance of a successful translation of preclinical results to clinical settings. The mission of choosing a behavioral test for a particular project is, therefore, imperative and the present review aims to provide a structured way to evaluate rodent behavioral tests with implications in ischemic stroke.
authors.affiliation: School of Biotechnology, National Institute of Technology, Calicut, 673601, India.
authors.forename: Sreekala S
authors.initials: SS
authors.lastname: Nampoothiri
authors.affiliation: School of Biotechnology, National Institute of Technology, Calicut, 673601, India.
authors.forename: Tanvi
authors.initials: T
authors.lastname: Potluri
authors.affiliation: School of Biotechnology, National Institute of Technology, Calicut, 673601, India.
authors.forename: Harshith
authors.initials: H
authors.lastname: Subramanian
authors.affiliation: School of Biotechnology, National Institute of Technology, Calicut, 673601, India. rajanikant@nitc.ac.in.
authors.forename: Rajanikant G
authors.initials: RG
authors.lastname: Krishnamurthy
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000175:diagnosis* / Q000523:psychology*; D005106:Exploratory Behavior / Q000502:physiology; D018737:Hand Strength / Q000502:physiology; D051379:Mice; D009043:Motor Activity / Q000502:physiology*; D051381:Rats; D045442:Rotarod Performance Test / Q000379:methods / Q000523:psychology; D020521:Stroke / Q000175:diagnosis* / Q000523:psychology*
keywords: Behavioral; Cognitive; Ischemic stroke; Rodents; Sensorimotor