title: The parietal memory network activates similarly for true and associative false recognition elicited via the DRM procedure.
abstract: Neuroimaging investigations of human memory encoding and retrieval have revealed that multiple regions of parietal cortex contribute to memory. Recently, a sparse network of regions within parietal cortex has been identified using resting state functional connectivity (MRI techniques). The regions within this network exhibit consistent task-related responses during memory formation and retrieval, leading to its being called the parietal memory network (PMN). Among its signature patterns are: deactivation during initial experience with an item (e.g., encoding); activation during subsequent repetitions (e.g., at retrieval); greater activation for successfully retrieved familiar words than novel words (e.g., hits relative to correctly-rejected lures). The question of interest here is whether novel words that are subjectively experienced as having been recently studied would elicit PMN activation similar to that of hits. That is, we compared old items correctly recognized to two types of novel items on a recognition test: those correctly identified as new and those incorrectly labeled as old due to their strong associative relation to the studied words (in the DRM false memory protocol). Subjective oldness plays a strong role in driving activation, as hits and false alarms activated similarly (and greater than correctly-rejected lures).
authors.affiliation: Department of Psychological & Brain Sciences, Washington University in St. Louis, St Louis, MO, USA; Department of Radiology, Washington University School of Medicine, St Louis, MO, USA. Electronic address: kathleen.mcdermott@wustl.edu.
authors.forename: Kathleen B
authors.initials: KB
authors.lastname: McDermott
authors.affiliation: Department of Psychological & Brain Sciences, Washington University in St. Louis, St Louis, MO, USA.
authors.forename: Adrian W
authors.initials: AW
authors.lastname: Gilmore
authors.affiliation: VISN 17 Center for Excellence for Research on Returning War Veterans, Waco, TX, USA; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA; Baylor University, Department of Psychology and Neuroscience, Waco, TX, USA.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Nelson
authors.affiliation: Department of Psychology, University of Colorado Denver, Denver, CO, USA.
authors.forename: Jason M
authors.initials: JM
authors.lastname: Watson
authors.affiliation: Department of Neurological Surgery, University of Washington, Seattle Children's Hospital, Seattle, WA, USA.
authors.forename: Jeffrey G
authors.initials: JG
authors.lastname: Ojemann
mesh_terms: D000293:Adolescent; D000328:Adult; D001244:Association; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D008569:Memory Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000523:psychology; D009415:Nerve Net / Q000000981:diagnostic imaging / Q000503:physiopathology*; D010296:Parietal Lobe / Q000000981:diagnostic imaging / Q000502:physiology*; D021641:Recognition, Psychology / Q000502:physiology*; D055815:Young Adult
keywords: DRM; False alarm; False memory; Retrieval success; fMRI