title: Authentication of gold nanoparticle encoded pharmaceutical tablets using polarimetric signatures.
abstract: The counterfeiting of pharmaceutical products represents concerns for both industry and the safety of the general public. Falsification produces losses to companies and poses health risks for patients. In order to detect fake pharmaceutical tablets, we propose producing film-coated tablets with gold nanoparticle encoding. These coated tablets contain unique polarimetric signatures. We present experiments to show that ellipsometric optical techniques, in combination with machine learning algorithms, can be used to distinguish genuine and fake samples. To the best of our knowledge, this is the first report using gold nanoparticles encoded with optical polarimetric classifiers to prevent the counterfeiting of pharmaceutical products.
authors.forename: Artur
authors.initials: A
authors.lastname: Carnicer
authors.forename: Oriol
authors.initials: O
authors.lastname: Arteaga
authors.forename: Josep M
authors.initials: JM
authors.lastname: Suñé-Negre
authors.forename: Bahram
authors.initials: B
authors.lastname: Javidi
mesh_terms: D000465:Algorithms; D006046:Gold; D053768:Metal Nanoparticles; D004364:Pharmaceutical Preparations; D013057:Spectrum Analysis; D013607:Tablets
chemical_list: D004364:Pharmaceutical Preparations; D013607:Tablets; D006046:Gold