title: Gynandroblastoma with a Juvenile Granulosa Cell Component in an Adolescent: Case Report and Literature Review.
abstract: BACKGROUND
  Gynandroblastoma is an extremely rare ovarian sex cord tumor with malignant potential.
  
  
  METHODS
  An 18-year-old adolescent experienced intermittent vaginal bleeding. A year later, a right adnexal mass with a heterogeneous imaging appearance was identified. Laparoendoscopic single-site ovarian tumorectomy was performed. A histopathological examination showed gynandroblastoma composed of juvenile granulosa and Sertoli-Leydig cells. Because the tumor was upstaged to stage Ic because of cyst rupture during surgery, three cycles of adjuvant chemotherapy with carboplatin and paclitaxel were added. Three years after surgery, no signs of recurrence have been noted.
  
  
  CONCLUSIONS
  The present findings can help clinicians make an accurate preoperative imaging diagnosis of gynandroblastoma with a juvenile granulosa cell component and plan an adequate treatment strategy for this rare, potentially malignant neoplasm.
authors.affiliation: Department of Obstetrics and Gynecology, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu, Japan. Electronic address: gyendoscopy@gmail.com.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Takeda
authors.affiliation: Department of Diagnostic Pathology, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu, Japan.
authors.forename: Kazuko
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: Department of Obstetrics and Gynecology, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu, Japan.
authors.forename: Shotaro
authors.initials: S
authors.lastname: Hayashi
authors.affiliation: Department of Obstetrics and Gynecology, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu, Japan.
authors.forename: Sanae
authors.initials: S
authors.lastname: Imoto
authors.affiliation: Department of Obstetrics and Gynecology, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Nakamura
mesh_terms: D000291:Adnexal Diseases / Q000150:complications / Q000473:pathology* / Q000628:therapy; D000293:Adolescent; D017024:Chemotherapy, Adjuvant; D005260:Female; D006106:Granulosa Cell Tumor / Q000150:complications / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008796:Metrorrhagia / Q000209:etiology; D010051:Ovarian Neoplasms / Q000150:complications / Q000473:pathology* / Q000628:therapy; D018312:Sex Cord-Gonadal Stromal Tumors / Q000150:complications / Q000473:pathology* / Q000628:therapy
keywords: Adjuvant chemotherapy; Adolescent; Gynandroblastoma; Imaging; Juvenile granulosa cell; Laparoendoscopic single-site surgery; Ovarian preservation