title: The effect of exercise on skeletal muscle fibre type distribution in obesity: From cellular levels to clinical application.
abstract: Skeletal muscles play important roles in metabolism, energy expenditure, physical strength, and locomotive activity. Skeletal muscle fibre types in the body are heterogeneous. They can be classified as oxidative types and glycolytic types with oxidative-type are fatigue-resistant and use oxidative metabolism, while fibres with glycolytic-type are fatigue-sensitive and prefer glycolytic metabolism. Several studies demonstrated that an obese condition with abnormal metabolic parameters has been negatively correlated with the distribution of oxidative-type skeletal muscle fibres, but positively associated with that of glycolytic-type muscle fibres. However, some studies demonstrated otherwise. In addition, several studies demonstrated that an exercise training programme caused the redistribution of oxidative-type skeletal muscle fibres in obesity. In contrast, some studies showed inconsistent findings. Therefore, the present review comprehensively summarizes and discusses those consistent and inconsistent findings from clinical studies, regarding the association among the distribution of skeletal muscle fibre types, obese condition, and exercise training programmes. Furthermore, the possible underlying mechanisms and clinical application of the alterations in muscle fibre type following obesity are presented and discussed.
authors.affiliation: Department of Rehabilitation Medicine, Faculty of Medicine, Chiang Mai University, Thailand; Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Thailand; Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Thailand; Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Thailand.
authors.forename: Sintip
authors.initials: S
authors.lastname: Pattanakuhar
authors.affiliation: Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Thailand; Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Thailand; Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Thailand.
authors.forename: Anchalee
authors.initials: A
authors.lastname: Pongchaidecha
authors.affiliation: Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Thailand; Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Thailand; Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Thailand.
authors.forename: Nipon
authors.initials: N
authors.lastname: Chattipakorn
authors.affiliation: Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Thailand; Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Thailand; Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand. Electronic address: scchattipakorn@gmail.com.
authors.forename: Siriporn C
authors.initials: SC
authors.lastname: Chattipakorn
mesh_terms: D000328:Adult; D004734:Energy Metabolism; D015444:Exercise / Q000502:physiology*; D005260:Female; D006019:Glycolysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D018485:Muscle Fibers, Skeletal / Q000145:classification / Q000473:pathology / Q000502:physiology*; D053580:Muscle Strength; D018482:Muscle, Skeletal / Q000473:pathology / Q000503:physiopathology*; D009765:Obesity / Q000473:pathology / Q000503:physiopathology*; D010084:Oxidation-Reduction
keywords: Exercise; Fibre type; Obesity; Skeletal muscle