title: Effect of Diet on Serum Creatinine in Healthy Subjects During a Phase I Study.
abstract: Creatinine is widely used as an indirect marker of renal function. However, interfering factors such as diet, exercise and problems with the assay can generate false results and misinterpretation of real kidney function. In this article, we report the dietary effects on serum creatinine during a phase I single dose escalation study and discuss the reasons why serum creatinine should be measured under fasting conditions.
authors.affiliation: Experimental Medicine CV/Hem, Clinical Sciences, Drug Discovery, Bayer Pharma AG, Wuppertal, Germany.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Pimenta
authors.affiliation: Clinical Pharmacology CV/Hem, Clinical Sciences, Drug Discovery, Bayer Pharma AG, Wuppertal, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Jensen
authors.affiliation: Clinical Pharmacology CV/Hem, Clinical Sciences, Drug Discovery, Bayer Pharma AG, Wuppertal, Germany.
authors.forename: David
authors.initials: D
authors.lastname: Jung
authors.affiliation: CRS Clinical Research Services Wuppertal GmbH, Wuppertal, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Schaumann
authors.affiliation: CRS Clinical Research Services Wuppertal GmbH, Wuppertal, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Boxnick
authors.affiliation: Experimental Medicine CV/Hem, Clinical Sciences, Drug Discovery, Bayer Pharma AG, Wuppertal, Germany; Witten/Herdecke University, Witten, Germany.
authors.forename: Hubert
authors.initials: H
authors.lastname: Truebel
keywords: Chronic kidney disease; Creatinine; Kidney