title: 90Y Digital PET/CT Imaging Following Radioembolization.
abstract: Imaging of Y internal pair production with conventional photomultiplier detector PET technology has been previously reported for patients with malignant/metastatic liver lesions treated with Y radioembolization (RE). We present a 54-year-old man with unresectable liver metastases from rectal carcinoma (involving the right and left lobes) who was referred for Y RE and subsequently imaged using new solid-state digital photon counting technology (Vereos 64 Time-of-Flight PET/CT; Philips, Cleveland, OH). Despite imaging at 26 hours following RE, digital PET/CT provides improved image quality and Y-to-background contrast as well as accurate visualization of Y biodistribution when compared with Bremsstrahlung SPECT/CT.
authors.affiliation: From the *Wright Center of Innovation and Biomedical Imaging, Department of Radiology, and †Department of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH.
authors.forename: Chadwick L
authors.initials: CL
authors.lastname: Wright
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Katherine
authors.initials: K
authors.lastname: Binzel
authors.forename: Evan J
authors.initials: EJ
authors.lastname: Wuthrick
authors.forename: Michael V
authors.initials: MV
authors.lastname: Knopp
mesh_terms: D004621:Embolization, Therapeutic; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics / Q000627:therapeutic use; D014018:Tissue Distribution; D015021:Yttrium Radioisotopes / Q000493:pharmacokinetics / Q000627:therapeutic use
chemical_list: D019275:Radiopharmaceuticals; D015021:Yttrium Radioisotopes