title: Roles of WNT, NOTCH, and Hedgehog signaling in the differentiation and function of innate and innate-like lymphocytes.
abstract: Innate lymphoid cells (ILCs) and innate-like lymphocytes have important roles in immune responses in the context of infection, cancer, and autoimmunity. The factors involved in driving the differentiation and function of these cell types remain to be clearly defined. There are several cellular signaling pathways involved in embryogenesis, which continue to function in adult tissue. In particular, the WNT, NOTCH, and Hedgehog signaling pathways are emerging as regulators of hematopoietic cell development and differentiation. This review discusses the currently known roles of WNT, NOTCH, and Hedgehog signaling in the differentiation and function of ILCs and innate-like lymphocytes.
authors.affiliation: The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia; and j.kling@uq.edu.au.
authors.forename: Jessica C
authors.initials: JC
authors.lastname: Kling
authors.affiliation: The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia; and a.blumenthal@uq.edu.au.|Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Antje
authors.initials: A
authors.lastname: Blumenthal
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D008214:Lymphocytes / Q000166:cytology* / Q000276:immunology*; D008954:Models, Biological; D015398:Signal Transduction / Q000276:immunology*
keywords: B1 cell; NK cell; NKT cell; innate lymphoid cell; marginal zone B cell; γδ T cell