title: Evaluation of Feline Renal Perfusion with Contrast-Enhanced Ultrasonography and Scintigraphy.
abstract: Contrast-enhanced ultrasound (CEUS) is an emerging technique to evaluate tissue perfusion. Promising results have been obtained in the evaluation of renal perfusion in health and disease, both in human and veterinary medicine. Renal scintigraphy using 99mTc-Mercaptoacetyltriglycine (MAG3) is another non-invasive technique that can be used to evaluate renal perfusion. However, no data are available on the ability of CEUS or 99mTc- MAG3 scintigraphy to detect small changes in renal perfusion in cats. Therefore, both techniques were applied in a normal feline population to evaluate detection possibilities of perfusion changes by angiotensin II (AT II). Contrast-enhanced ultrasound using a bolus injection of commercially available contrast agent and renal scintigraphy using 99mTc-MAG3 were performed in 11 healthy cats after infusion of 0,9% NaCl (control) and AT II. Angiotensin II induced changes were noticed on several CEUS parameters. Mean peak enhancement, wash-in perfusion index and wash-out rate for the entire kidney decreased significantly after AT II infusion. Moreover, a tendency towards a lower wash-in area-under-the curve was present. Renal scintigraphy could not detect perfusion changes induced by AT II. This study shows that CEUS is able to detect changes in feline renal perfusion induced by AT II infusion.
authors.affiliation: Department of Medical Imaging of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium.
authors.forename: Emmelie
authors.identifier: http://orcid.org/0000-0002-9982-1532
authors.initials: E
authors.lastname: Stock
authors.affiliation: Department of Medical Imaging of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium.
authors.forename: Katrien
authors.initials: K
authors.lastname: Vanderperren
authors.affiliation: Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium.
authors.forename: Tim
authors.initials: T
authors.lastname: Bosmans
authors.affiliation: Ghent University Hospital, Department of Radiology and Nuclear Medicine, De Pintelaan 185, 9000 Ghent, Belgium.
authors.forename: André
authors.initials: A
authors.lastname: Dobbeleir
authors.affiliation: Department of Comparative Physiology and Biometry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium.
authors.forename: Luc
authors.initials: L
authors.lastname: Duchateau
authors.affiliation: Department of Nutrition, Genetics and Ethology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium.
authors.forename: Myriam
authors.initials: M
authors.lastname: Hesta
authors.affiliation: Lab of Pharmaceutical technology, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, Ghent, Belgium.
authors.forename: Lien
authors.initials: L
authors.lastname: Lybaert
authors.affiliation: Department of Medical Imaging of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium.
authors.forename: Kathelijne
authors.initials: K
authors.lastname: Peremans
authors.affiliation: Department of Medical Imaging of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium.
authors.forename: Eva
authors.initials: E
authors.lastname: Vandermeulen
authors.affiliation: Department of Medical Imaging of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium.
authors.forename: Jimmy
authors.initials: J
authors.lastname: Saunders
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D002415:Cats; D003287:Contrast Media / Q000737:chemistry*; D007668:Kidney / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000502:physiology; D011877:Radionuclide Imaging; D013667:Technetium / Q000737:chemistry; D014463:Ultrasonography
chemical_list: D003287:Contrast Media; D000804:Angiotensin II; D013667:Technetium