title: The effect and safety of highly standardized Ginger (Zingiber officinale) and Echinacea (Echinacea angustifolia) extract supplementation on inflammation and chronic pain in NSAIDs poor responders. A pilot study in subjects with knee arthrosis.
abstract: The study aimed to evaluate the effect of Zingiber officinale and Echinacea angustifolia extract supplementation (25 mg of ginger and 5 mg of Echinacea) for 30 days on inflammation and chronic pain in knee osteoarthritis (OA). Consecutive nonsteroidal anti-inflammatory-drugs (NSAIDs) poor responders with chronic inflammation and pain due to knee arthrosis were assessed (15 subjects, age: 67.2 ± 7.9, body mass index: 30.6 ± 7.1, men/women:2/13). The primary endpoint was to determine pain improvement from baseline to Day 30 by Tegner Lysholm Knee Scoring. The secondary endpoints were the assessment of Visual Analog Scale for Pain, health-related quality of life, by the ShortForm36 (SF-36), anthropometric parameters, hydration. After supplementation, a significant improvement of 12.27 points was observed for Lysholm scale score (p < 0.05), SF-36 (p < 0.05), and a decrease in -0.52 cm in knee circumference (left) (p < 0.01). This pilot study provides feasibility and safety data for the use of highly standardised ginger and Echinacea extract supplementation in people with knee OA.
authors.affiliation: a Department of Public Health, Experimental and Forensic Medicine, Section of Human Nutri tion and Dietetics, Azienda di Servizialla Persona di Pavia , University of Pavia , Pavia , Italy.
authors.forename: Mariangela
authors.initials: M
authors.lastname: Rondanelli
authors.affiliation: b Research and Development Unit , Indena , Milan , Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Riva
authors.affiliation: b Research and Development Unit , Indena , Milan , Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Morazzoni
authors.affiliation: b Research and Development Unit , Indena , Milan , Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Allegrini
authors.affiliation: a Department of Public Health, Experimental and Forensic Medicine, Section of Human Nutri tion and Dietetics, Azienda di Servizialla Persona di Pavia , University of Pavia , Pavia , Italy.
authors.forename: Milena Anna
authors.initials: MA
authors.lastname: Faliva
authors.affiliation: a Department of Public Health, Experimental and Forensic Medicine, Section of Human Nutri tion and Dietetics, Azienda di Servizialla Persona di Pavia , University of Pavia , Pavia , Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Naso
authors.affiliation: a Department of Public Health, Experimental and Forensic Medicine, Section of Human Nutri tion and Dietetics, Azienda di Servizialla Persona di Pavia , University of Pavia , Pavia , Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Miccono
authors.affiliation: a Department of Public Health, Experimental and Forensic Medicine, Section of Human Nutri tion and Dietetics, Azienda di Servizialla Persona di Pavia , University of Pavia , Pavia , Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Peroni
authors.affiliation: c Department of Physiatry , Azienda di Servizi alla Persona "Istituto Santa Margherita" , Pavia , Italy.
authors.forename: Irene
authors.initials: I
authors.lastname: Degli Agosti
authors.affiliation: a Department of Public Health, Experimental and Forensic Medicine, Section of Human Nutri tion and Dietetics, Azienda di Servizialla Persona di Pavia , University of Pavia , Pavia , Italy.
authors.forename: Simone
authors.initials: S
authors.lastname: Perna
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D059350:Chronic Pain / Q000188:drug therapy*; D019587:Dietary Supplements; D020900:Echinacea / Q000737:chemistry*; D005260:Female; D020939:Zingiber officinale / Q000737:chemistry*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000188:drug therapy*; D010147:Pain Measurement / Q000379:methods; D010865:Pilot Projects; D010936:Plant Extracts / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D011788:Quality of Life; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts
keywords: Chronic pain; Echinacea angustifolia; Zingiber officinale; arthritis; dietary supplement; ginger; inflammation; knee osteoarthritis