title: Infants with low vaccine antibody responses have altered innate cytokine response.
abstract: We recently identified a population of 10% of infants who respond with sub-protective antibody levels to most routine primary pediatric vaccinations due to altered innate and adaptive immune responses. We term these infants as low vaccine responders (LVRs). Here we report new data showing that TLR7/8 agonist - R848 stimulation of PBMCs of LVR infants elicit significantly lower IFN-α, IL-12p70 and IL-1β, while inducing higher levels of CCL5 (RANTES) compared to normal vaccine responder (NVR) infants.
authors.affiliation: Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, Rochester Regional Health System, 1425 Portland Ave, Rochester, NY, United States.
authors.forename: Naveen
authors.initials: N
authors.lastname: Surendran
authors.affiliation: Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, Rochester Regional Health System, 1425 Portland Ave, Rochester, NY, United States.
authors.forename: Ted
authors.initials: T
authors.lastname: Nicolosi
authors.affiliation: Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, Rochester Regional Health System, 1425 Portland Ave, Rochester, NY, United States; Legacy Pediatrics, Rochester, NY, United States. Electronic address: Michael.Pichichero@rochesterregional.org.
authors.forename: Michael
authors.initials: M
authors.lastname: Pichichero
mesh_terms: D056704:Adaptive Immunity; D000917:Antibody Formation / Q000276:immunology*; D002478:Cells, Cultured; D018946:Chemokine CCL5 / Q000097:blood; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology; D007113:Immunity, Innate; D007223:Infant; D016898:Interferon-alpha / Q000097:blood / Q000187:drug effects; D018664:Interleukin-12 / Q000037:antagonists & inhibitors / Q000097:blood; D053583:Interleukin-1beta / Q000097:blood / Q000187:drug effects; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology*; D008137:Longitudinal Studies; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D051199:Toll-Like Receptor 7 / Q000037:antagonists & inhibitors; D051200:Toll-Like Receptor 8 / Q000037:antagonists & inhibitors; D014611:Vaccination; D014612:Vaccines / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D018946:Chemokine CCL5; D007093:Imidazoles; D016898:Interferon-alpha; D053583:Interleukin-1beta; C495348:TLR7 protein, human; C495349:TLR8 protein, human; D051199:Toll-Like Receptor 7; D051200:Toll-Like Receptor 8; D014612:Vaccines; D018664:Interleukin-12; C402365:resiquimod
keywords: IFN-α; IL12p70; IRF7; Infant innate immunity; Low vaccine response; RANTES