title: A conformal hydrogel nanocomposite for local delivery of paclitaxel.
abstract: Conventional surgical methods can not completely remove the tumor cells, and an inevitable recurrence always results in death. In this study, we prepared a conformal hydrogel nanocomposite with potential to inhibit the recurrence of glioma. Based on the MRI of a patient's brain tumor cavity (BTC), we 3D-printed a mould for preparing the customized implants that could match the resection cavity. The obtained macroporous hydrogel, containing Paclitaxel (PTX) nanoparticles, could sustained release PTX. From the confocal microscopy image, we could detect that the hydrogel nanocomposite combined with nanoparticles uniformly. The nanoparticles were fabricated through a self-assembled process with PTX. Moreover, the in vitro studies showed that nanoparticles could release PTX slowly and efficiently inhibited the proliferation of tumor cells. This work prepared a conformal hydrogel nanocomposite for local delivery of paclitaxel, which could inspire the development of future protocols for precision therapy of residual glioma after surgical resection.
authors.affiliation: a School of Materials Science and Engineering , Sichuan University , Chengdu , China.
authors.forename: Jie
authors.initials: J
authors.lastname: Tao
authors.affiliation: b State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School , Sichuan University , Chengdu , China.
authors.forename: Jiumeng
authors.initials: J
authors.lastname: Zhang
authors.affiliation: c Department of Neurosurgery, West China Hospital , Sichuan University , Chengdu , China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Hu
authors.affiliation: c Department of Neurosurgery, West China Hospital , Sichuan University , Chengdu , China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yang
authors.affiliation: b State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School , Sichuan University , Chengdu , China.
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Gou
authors.affiliation: b State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School , Sichuan University , Chengdu , China.
authors.forename: Ting
authors.initials: T
authors.lastname: Du
authors.affiliation: a School of Materials Science and Engineering , Sichuan University , Chengdu , China.
authors.forename: Jian
authors.initials: J
authors.lastname: Mao
authors.affiliation: b State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School , Sichuan University , Chengdu , China.
authors.forename: Maling
authors.initials: M
authors.lastname: Gou
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000473:pathology; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D005910:Glioma / Q000473:pathology; D020100:Hydrogels / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry*; D017239:Paclitaxel / Q000737:chemistry* / Q000378:metabolism; D051381:Rats
chemical_list: D004337:Drug Carriers; D020100:Hydrogels; D017239:Paclitaxel
keywords: Glioma; Paclitaxel; drug delivery; nanocomposite; nanoparticles