title: Development of Mushroom-Based Cosmeceutical Formulations with Anti-Inflammatory, Anti-Tyrosinase, Antioxidant, and Antibacterial Properties.
abstract: The cosmetic industry is in a constant search for natural compounds or extracts with relevant bioactive properties, which became valuable ingredients to design cosmeceutical formulations. Mushrooms have been markedly studied in terms of nutritional value and medicinal properties. However, there is still slow progress in the biotechnological application of mushroom extracts in cosmetic formulations, either as antioxidants, anti-aging, antimicrobial, and anti-inflammatory agents or as hyperpigmentation correctors. In the present work, the cosmeceutical potential of ethanolic extracts prepared fromAgaricus bisporus,Pleurotus ostreatus, andLentinula edodeswas analyzed in terms of anti-inflammatory, anti-tyrosinase, antioxidant, and antibacterial activities. The extracts were characterized in terms of phenolic acids and ergosterol composition, and further incorporated in a base cosmetic cream to achieve the same bioactive purposes. From the results obtained, the final cosmeceutical formulations presented 85%-100% of the phenolic acids and ergosterol levels found in the mushroom extracts, suggesting that there was no significant loss of bioactive compounds. The final cosmeceutical formulation also displayed all the ascribed bioactivities and as such, mushrooms can further be exploited as natural cosmeceutical ingredients.
authors.affiliation: Mountain Research Centre (CIMO), ESA, Polytechnic Institute of Bragança, Campus de Santa Apolónia, 1172, 5300-253 Bragança, Portugal. taofiq.oludemi@ipb.pt.|GIP-USAL, Unidad de Nutrición y Bromatología, Faculty of Pharmacy, University of Salamanca, Campus Miguel de Unamuno, 37007 Salamanca, Spain. taofiq.oludemi@ipb.pt.|Laboratory of Separation and Reaction Engineering (LSRE), Associate Laboratory LSRE/LCM, Polytechnic Institute of Bragança, Campus de Santa Apolónia, 1134, 5301-857 Bragança, Portugal. taofiq.oludemi@ipb.pt.
authors.forename: Oludemi
authors.initials: O
authors.lastname: Taofiq
authors.affiliation: Mountain Research Centre (CIMO), ESA, Polytechnic Institute of Bragança, Campus de Santa Apolónia, 1172, 5300-253 Bragança, Portugal. sheleno@ipb.pt.|Laboratory of Separation and Reaction Engineering (LSRE), Associate Laboratory LSRE/LCM, Polytechnic Institute of Bragança, Campus de Santa Apolónia, 1134, 5301-857 Bragança, Portugal. sheleno@ipb.pt.
authors.forename: Sandrina A
authors.initials: SA
authors.lastname: Heleno
authors.affiliation: Mountain Research Centre (CIMO), ESA, Polytechnic Institute of Bragança, Campus de Santa Apolónia, 1172, 5300-253 Bragança, Portugal. callelha@ipb.pt.
authors.forename: Ricardo C
authors.initials: RC
authors.lastname: Calhelha
authors.affiliation: School of Health, Polytechnic Institute of Bragança, Av. D. Afonso V, 5300-121 Bragança, Portugal. maria.alves@ipb.pt.
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Alves
authors.affiliation: Mountain Research Centre (CIMO), ESA, Polytechnic Institute of Bragança, Campus de Santa Apolónia, 1172, 5300-253 Bragança, Portugal. lillian@ipb.pt.
authors.forename: Lillian
authors.initials: L
authors.lastname: Barros
authors.affiliation: Laboratory of Separation and Reaction Engineering (LSRE), Associate Laboratory LSRE/LCM, Polytechnic Institute of Bragança, Campus de Santa Apolónia, 1134, 5301-857 Bragança, Portugal. barreiro@ipb.pt.
authors.forename: Maria Filomena
authors.initials: MF
authors.lastname: Barreiro
authors.affiliation: GIP-USAL, Unidad de Nutrición y Bromatología, Faculty of Pharmacy, University of Salamanca, Campus Miguel de Unamuno, 37007 Salamanca, Spain. paramas@usal.es.
authors.forename: Ana M
authors.initials: AM
authors.lastname: González-Paramás
authors.affiliation: Mountain Research Centre (CIMO), ESA, Polytechnic Institute of Bragança, Campus de Santa Apolónia, 1172, 5300-253 Bragança, Portugal. iferreira@ipb.pt.
authors.forename: Isabel C F R
authors.initials: IC
authors.lastname: Ferreira
mesh_terms: D000364:Agaricus / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D000068937:Cosmeceuticals / Q000737:chemistry / Q000494:pharmacology; D055808:Drug Discovery; D004875:Ergosterol / Q000737:chemistry / Q000494:pharmacology*; D062385:Hydroxybenzoates / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000032:analysis* / Q000494:pharmacology; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D000068937:Cosmeceuticals; D062385:Hydroxybenzoates; D010936:Plant Extracts; D047428:Protein Kinase Inhibitors; C017616:phenolic acid; D004875:Ergosterol
keywords: anti-inflammatory; anti-tyrosinase; antibacterial; antioxidant; cosmeceutical formulation; mushrooms extracts; skin aging