title: Epidemiological Features of Hand, Foot and Mouth Disease during the Period of 2008-14 in Wenzhou, China.
abstract: This study aimed to analyze the epidemiological characteristics of hand, foot and mouth disease (HFMD) during 2008-14 in Wenzhou, China. The epidemiological data of HFMD retrieved from the Wenzhou Center for Disease Control and Prevention were retrospectively analyzed. HFMD infections with enterovirus 71 (EV71), Cox A16 or other pathogens were further verified by polymerase chain reaction (PCR) and real-time PCR. A total of 213 617 cases of HFMD were reported between 2008 and 2014 in Wenzhou. The average incidence was 384.31 of 100 000, and the fatality rate was 0.14‰. The incidence of HFMD peaked between April and July, and it occurred more frequently in males than in females. Approximately 92.68% of the HFMD patients were children aged <5 years. Nearly 80% of the cases were diagnosed within 2 days after onset. The major HFMD pathogen was EV71. This study suggested that appropriate comprehensive prevention and control measures should be taken to avoid the spread of HFMD.
authors.affiliation: Department of Emergency Response, Wenzhou Center for Disease Control and Prevention, Wenzhou, Zhejiang, 325000, China.
authors.forename: Zu-Mu
authors.initials: ZM
authors.lastname: Zhou
authors.affiliation: Department of Emergency Response, Wenzhou Center for Disease Control and Prevention, Wenzhou, Zhejiang, 325000, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Emergency Response, Wenzhou Center for Disease Control and Prevention, Wenzhou, Zhejiang, 325000, China.
authors.forename: Cai-Song
authors.initials: CS
authors.lastname: Hu
authors.affiliation: Department of infectious disease control and prevention, Wenzhou Center for Disease Control and Prevention, Wenzhou, Zhejiang, 325000, China.
authors.forename: Qiong-Jiao
authors.initials: QJ
authors.lastname: Pan
authors.affiliation: Department of infectious disease control and prevention, Wenzhou Center for Disease Control and Prevention, Wenzhou, Zhejiang, 325000, China.
authors.forename: Jing-Jiao
authors.initials: JJ
authors.lastname: Wei
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D003384:Coxsackievirus Infections / Q000175:diagnosis* / Q000453:epidemiology; D029821:Enterovirus A, Human / Q000235:genetics / Q000302:isolation & purification*; D006232:Hand, Foot and Mouth Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology*; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011156:Population Density; D012367:RNA, Viral / Q000235:genetics; D012189:Retrospective Studies
chemical_list: D012367:RNA, Viral
keywords: : hand; epidemiological characteristics; epidemiology.; foot and mouth disease (HFMD)