title: Low expression of miR-409-3p is a prognostic marker for breast cancer.
abstract: The present study aimed to clarify the expression pattern and prognostic role of miR-409-3p in breast cancer patients.
  
  
  
  miR-409-3p levels in breast cancer tissues were tested by qRT-PCR. The chi-square test and Fishers exact tests were used to examine the associations between miR-409-3p expression and the clinicopathological characters. Overall survival (OS) was estimated using the Kaplan-Meier method. The univariable and the multivariable Cox regression analyses were used to evaluate independent prognostic factors.
  
  
  
  miR-409-3p expression in breast cancer specimens was observed to be decreased compared with matched normal breast tissues (p < 0.01). Additionally, low miR-409-3p expression in breast cancer tissues was significantly associated with the advanced TNM stage (p = 0.004), lymph node metastasis (p = 0.001), and poorer pathological differentiation (p = 0.026). The patients in the low miR-409-3p group had a shorter overall survival than those in the high miR-409-3p group (p < 0.001). Furthermore, the univariate and the multivariate analyses showed that miR-409-3p expression was an independent predictor of overall survival (p < 0.05).
  
  
  
  Our results revealed that miR-409-3p was related to the prognosis of patients with breast cancer and might be a promising predictor of miR-409-3p recurrence.
authors.affiliation: Department of Radiology, Shulan Hangzhou Hospital, Hangzhou, Zhejiang, China. rrio939@163.com.
authors.forename: G-H
authors.initials: GH
authors.lastname: Cao
authors.forename: X-L
authors.initials: XL
authors.lastname: Sun
authors.forename: F
authors.initials: F
authors.lastname: Wu
authors.forename: W-F
authors.initials: WF
authors.lastname: Chen
authors.forename: J-Q
authors.initials: JQ
authors.lastname: Li
authors.forename: W-C
authors.initials: WC
authors.lastname: Hu
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053208:Kaplan-Meier Estimate; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis
chemical_list: C572367:MIRN409 microRNA, human; D035683:MicroRNAs