title: Consumption of a drink containing extruded sorghum reduces glycaemic response of the subsequent meal.
abstract: OBJECTIVE
  Glycaemic control is essential to prevent the manifestation of diabetes in predisposed individuals and the development of associated comorbidities. It is believed that sorghum may modulate the glucose response. In this study, we investigated the effect of extruded sorghum consumption, and the profile of bioactive compounds, on postprandial glycaemia of a subsequent meal in normal weight and normoglycaemic subjects.
  
  
  METHODS
  This was a randomized, single-blind, crossover designed study. After a 12 h overnight fasting, ten subjects reported to the laboratory to participate in four experimental sessions, and consumed one of three sorghum test drinks: sorghum P 3-DXAs (with proanthocyanidins-P and rich in 3-deoxyanthocyanidins-3-DXAs); 3-DXAs (without proanthocyanidins and rich in 3-DXAs); and control (low in 3-DXAs and without proanthocyanidins); or a non-sorghum drink. 30 min later, the subjects consumed a glucose solution (25 g glucose). Glycaemic response was monitored at times 0 (before glucose solution), 15, 30, 45, 60, 90, 120 min (after glucose solution consumption). The incremental areas under the glycaemic curve (iAUC) were calculated by the trapezoidal method.
  
  
  RESULTS
  Intake of P 3-DXAs drink before the glucose solution resulted in a postprandial iAUC lower than the other sorghum test drinks. Sorghum drinks minimized the postprandial glycaemia peak.
  
  
  CONCLUSIONS
  Sorghum drinks consumption, especially the P 3-DXAs drink, 30 min before the glucose solution resulted in lower iAUC compared to the non-sorghum drink, leading to a lower glycaemic response.
authors.affiliation: Departamento de Nutrição e Saúde, Universidade Federal de Viçosa, Viçosa, Minas Gerais, 36570-900, Brazil. nutripamella@gmail.com.
authors.forename: Pamella Cristine
authors.initials: PC
authors.lastname: Anunciação
authors.affiliation: Departamento de Nutrição, Universidade Federal de Juiz de Fora, Campus Governador Valadares, Governador Valadares, Minas Gerais, 35010-177, Brazil.
authors.forename: Leandro de Morais
authors.initials: LM
authors.lastname: Cardoso
authors.affiliation: Embrapa Milho e Sorgo, Sete Lagoas, Minas Gerais, 35701-970, Brazil.
authors.forename: Valéria Aparecida Vieira
authors.initials: VAV
authors.lastname: Queiroz
authors.affiliation: Embrapa Milho e Sorgo, Sete Lagoas, Minas Gerais, 35701-970, Brazil.
authors.forename: Cicero Beserra
authors.initials: CB
authors.lastname: de Menezes
authors.affiliation: Embrapa Agroindústria de Alimentos, Rio de Janeiro, 23020-470, Brazil.
authors.forename: Carlos Wanderlei Piler
authors.initials: CWP
authors.lastname: de Carvalho
authors.affiliation: Departamento de Nutrição e Saúde, Universidade Federal de Viçosa, Viçosa, Minas Gerais, 36570-900, Brazil.
authors.forename: Helena Maria
authors.initials: HM
authors.lastname: Pinheiro-Sant'Ana
authors.affiliation: Departamento de Nutrição e Saúde, Universidade Federal de Viçosa, Viçosa, Minas Gerais, 36570-900, Brazil.
authors.forename: Rita de Cássia Gonçalves
authors.initials: RCG
authors.lastname: Alfenas
mesh_terms: D000872:Anthocyanins / Q000008:administration & dosage; D001628:Beverages / Q000032:analysis*; D001786:Blood Glucose / Q000032:analysis*; D015992:Body Mass Index; D018592:Cross-Over Studies; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D008297:Male; D062407:Meals; D019518:Postprandial Period; D044945:Proanthocyanidins / Q000008:administration & dosage; D016037:Single-Blind Method; D045868:Sorghum
chemical_list: D000872:Anthocyanins; D001786:Blood Glucose; D044945:Proanthocyanidins; D005947:Glucose
keywords: Diabetes mellitus; Food and beverages; Glycaemic response; Sorghum