title: The Cost-efficiency and Care Effectiveness of Probiotic Administration with Antibiotics to Prevent Hospital-Acquired Clostridium difficile Infection.
abstract: Health care facility-acquired Clostridium difficile infections (HCFA-CDI) have increased over the last several decades despite facilities developing protocols for prescribing probiotics with antibiotics to prevent HCFA-CDI. The literature does not consistently support this. A retrospective medical record review evaluated the care effectiveness of this practice. Care effectiveness was not found; patients receiving probiotics with antibiotics were twice as likely to develop HCFA-CDI (P = .004). Except with glycopeptides, patients were 1.88 times less likely to experience HCFA-CDI (P = .05).
authors.affiliation: 1203 Dutilh Rd Unit 8, Cranberry Township, Pennsylvania (Dr Starn); School of Nursing and Health Sciences, Robert Morris University, Moon Township, Pennsylvania (Dr Hampe); and Alex G. McKenna School of Business, Saint Vincent College, Latrobe, Pennsylvania (Dr Cline).
authors.forename: Emily S
authors.initials: ES
authors.lastname: Starn
authors.forename: Holly
authors.initials: H
authors.lastname: Hampe
authors.forename: Thomas
authors.initials: T
authors.lastname: Cline
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D003015:Clostridium Infections / Q000517:prevention & control*; D003428:Cross Infection / Q000517:prevention & control*; D006801:Humans; D019936:Probiotics / Q000008:administration & dosage*; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents