title: Probiotics and Diverticular Disease: Evidence-based?
abstract: Diverticular disease (DD) is a common gastrointestinal condition. Clinical spectrum ranges from asymptomatic diverticulosis to symptomatic uncomplicated or complicated DD. Symptoms related to uncomplicated DD are not specific and may be indistinguishable from those of irritable bowel syndrome. Low-grade inflammation, altered intestinal microbiota, visceral hypersensitivity, and abnormal colonic motility have been identified as factors potentially contributing to symptoms. Probiotics may modify the gut microbial balance leading to health benefits. Probiotics, due to their anti-inflammatory effects and ability to maintain an adequate bacterial colonization in the colon, are promising treatment options for DD. This review focuses on the available evidence on the efficacy of prebiotics in uncomplicated DD.
authors.affiliation: Department of Medical and Surgical Sciences and Translational Medicine, Sant'Andrea Hospital, School of Medicine, University Sapienza, Rome, Italy.
authors.forename: Edith
authors.initials: E
authors.lastname: Lahner
authors.forename: Bruno
authors.initials: B
authors.lastname: Annibale
mesh_terms: D003106:Colon / Q000382:microbiology / Q000503:physiopathology; D000076385:Diverticular Diseases / Q000382:microbiology / Q000503:physiopathology / Q000628:therapy*; D019317:Evidence-Based Medicine / Q000379:methods*; D000069196:Gastrointestinal Microbiome; D005769:Gastrointestinal Motility; D006801:Humans; D056692:Prebiotics; D019936:Probiotics / Q000627:therapeutic use*
chemical_list: D056692:Prebiotics