title: Good Outcomes in Kidney Transplantation With Deceased Donor With Acute Kidney Injury: Donor's Age and Not Acute Kidney Injury Predicts Graft Function.
abstract: BACKGROUND
  With the increased demand for kidney transplants and the short supply of organs, it is necessary to have a better strategy to evaluate the available organs, especially from donors with acute kidney injury (AKI), because these organs are often rejected for transplantation.
  
  
  METHODS
  We evaluated patients undergoing transplantation with kidneys from deceased donors with AKI. The cases were divided into AKI stages according to the Acute Kidney Injury Network (AKIN) criteria. The outcomes examined were delayed graft function (DGF), creatinine (Cr), and creatinine clearance (CrCl) at 6 months after transplantation.
  
  
  RESULTS
  We evaluated 101 patients and included 53 in the final model. There was no statistical difference in the demographic characteristics, comorbidities, and immunosuppression according to each AKIN stage, showing a population of homogeneous transplant recipients. Recipients in AKIN stages I, II, and III, respectively had DGF in 72.7%, 61.9%, and 71.4% of cases; Cr of 1.6 ± 0.5, 1.7 ± 0.7, and 1.6 ± 0.2 mg/dL at 6 months; and CrCl of 60.6 ± 22.4, 52.4 ± 27.4, and 52.03 ± 12.1 mL/min at 6 months. Each additional year in donor age increased the relative risk of DGF by 1.08 (1.0-1.13) (P = .01), and organs from older donors were associated with worse renal function at 6 months.
  
  
  CONCLUSIONS
  Kidney transplantation of organs from deceased donors with AKI showed greater DGF but good outcomes. Donor age was the only characteristic that correlated with outcome.
authors.affiliation: Department of Internal Medicine-UNESP, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
authors.forename: H
authors.initials: H
authors.lastname: Si Nga
authors.affiliation: Department of Internal Medicine-UNESP, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
authors.forename: H M
authors.initials: HM
authors.lastname: Takase
authors.affiliation: Department of Internal Medicine-UNESP, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
authors.forename: A M
authors.initials: AM
authors.lastname: Bravin
authors.affiliation: Department of Internal Medicine-UNESP, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
authors.forename: P D
authors.initials: PD
authors.lastname: Garcia
authors.affiliation: Department of Internal Medicine-UNESP, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
authors.forename: M M
authors.initials: MM
authors.lastname: Contti
authors.affiliation: Department of Internal Medicine-UNESP, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
authors.forename: C A
authors.initials: CA
authors.lastname: Kojima
authors.affiliation: Department of Internal Medicine-UNESP, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil. Electronic address: landrade@fmb.unesp.br.
authors.forename: L G M
authors.initials: LG
authors.lastname: de Andrade
mesh_terms: D058186:Acute Kidney Injury / Q000503:physiopathology; D000328:Adult; D000367:Age Factors; D000368:Aged; D051799:Delayed Graft Function / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014019:Tissue Donors / Q000600:supply & distribution