title: Bioinformatics and functional analyses of coronavirus nonstructural proteins involved in the formation of replicative organelles.
abstract: Replication of eukaryotic positive-stranded RNA viruses is usually linked to the presence of membrane-associated replicative organelles. The purpose of this review is to discuss the function of proteins responsible for formation of the coronavirus replicative organelle. This will be done by identifying domains that are conserved across the order Nidovirales, and by summarizing what is known about function and structure at the level of protein domains.
authors.affiliation: University of Reading, School of Biological Sciences, RG6 6AH, United Kingdom; College of STEM, Texas A&M University-Texarkana, Texarkana, TX 75503, USA. Electronic address: bneuman@tamut.edu.
authors.forename: Benjamin W
authors.initials: BW
authors.lastname: Neuman
mesh_terms: D000818:Animals; D019295:Computational Biology; D017934:Coronavirus / Q000235:genetics / Q000502:physiology*; D004261:DNA Replication; D006056:Golgi Apparatus / Q000821:virology; D007425:Intracellular Membranes / Q000648:ultrastructure*; D051379:Mice; D015388:Organelles / Q000648:ultrastructure*; D012367:RNA, Viral / Q000235:genetics / Q000378:metabolism; D017361:Viral Nonstructural Proteins / Q000235:genetics / Q000378:metabolism*; D014779:Virus Replication
chemical_list: D012367:RNA, Viral; D017361:Viral Nonstructural Proteins; C087633:nonstructural protein, coronavirus