title: Propofol-Related Infusion Syndrome in the Peripartum Period.
abstract: BackgroundPropofol is a widely known, commonly used drug. Complications can occur with the use of this drug, including propofol-related infusion syndrome (PRIS). PRIS, in the obstetric population, has not been documented; however, we report a case of a patient who developed PRIS after an emergent cesarean delivery of a preterm infant.Case StudyA 35-year-old multigravida woman presented complaining of leakage of fluid and decreased fetal movement. Her pregnancy was complicated by methadone maintenance therapy due to a history of opioid abuse. Complications after admission for prolonged monitoring and a prolonged fetal heart tone deceleration was noted with no recovery despite intrauterine resuscitation. An emergent cesarean delivery was performed using general anesthesia and endotracheal intubation after which she developed aspiration pneumonia. She was admitted to the intensive care unit and reintubation and sedation were required secondary to respiratory distress. Sedation was achieved using propofol infusion. She subsequently developed changes in her electrocardiogram, an increase of her serum creatinine, creatinine protein kinase, lipase, amylase, and triglycerides, making the diagnosis of PRIS.ConclusionPRIS should be included in the differential diagnosis of intubated or postoperative patients in the obstetric population.
authors.affiliation: Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Health Science Center at Houston, Houston, Texas.
authors.forename: Akwugo A
authors.initials: AA
authors.lastname: Eziefule
authors.affiliation: Division of Female Pelvic Medicine and Reproductive Surgery, Department of Obstetrics and Gynecology, Henry Ford Health Systems, Detroit, Michigan.
authors.forename: Solafa
authors.initials: S
authors.lastname: Elshatanoufy
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan; Division of Genetic and Metabolic Disorders, Department of Pediatrics and Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan.
authors.forename: Mili
authors.initials: M
authors.lastname: Thakur
authors.affiliation: Department of Obstetrics and Gynecology, Hurley Medical Center, Michigan State University College of Human Medicine, Flint, Michigan.
authors.forename: Frederico G
authors.initials: FG
authors.lastname: Rocha
keywords: PRIS; infusion syndrome; obstetrics; pregnancy