title: [Autoimmune encephalitis due to mantle cell lymphoma].
abstract: Autoimmune encephalitis is a rare condition characterized by subacute development of cognitive and psychiatric symptoms. A paraneoplastic syndrome involves autoimmune encephalitis caused by classic antibodies. Although this condition is often associated with cancer, no malignancy has yet been found in 70-90% of patients at the time of diagnosis.
  
  
  
  We saw a 58-year-old male patient with fatigue, diarrhoea and weight loss. He was also experiencing hyperekplexia, personality changes and an instable gait. PET-CT revealed generalised lymphadenopathy. Histopathological analysis of a lymph node showed mantle cell lymphoma. Further investigation of the fluid revealed anti-DPPX IgG antibodies. We treated the patient's mantle cell lymphoma with R-CHOP; he achieved complete remission and his neurological symptoms resolved almost completely.
  
  
  
  The presence of anti-DPPX IgG antibodies is rare. Although it has not been proven that these antibodies are related to malignancies, this is the third of 30 known cases in which anti-DPPX IgG antibodies and a lymphatic malignancy were found.
authors.affiliation: Meander Medisch Centrum, Amersfoort.
authors.forename: A A H
authors.initials: AA
authors.lastname: Bressers
authors.forename: N A
authors.initials: NA
authors.lastname: Goto
authors.forename: S
authors.initials: S
authors.lastname: Piepers
authors.forename: J C
authors.initials: JC
authors.lastname: Regelink
mesh_terms: D058846:Antibodies, Monoclonal, Murine-Derived; D000971:Antineoplastic Combined Chemotherapy Protocols; D001323:Autoantibodies / Q000032:analysis*; D003520:Cyclophosphamide; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000032:analysis*; D004317:Doxorubicin; D004660:Encephalitis / Q000175:diagnosis* / Q000188:drug therapy*; D050031:Hashimoto Disease / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D008198:Lymph Nodes / Q000737:chemistry; D020522:Lymphoma, Mantle-Cell / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000032:analysis*; D015221:Potassium Channels / Q000032:analysis*; D011241:Prednisone; D000069283:Rituximab; D014750:Vincristine
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D001323:Autoantibodies; D009419:Nerve Tissue Proteins; D015221:Potassium Channels; C571759:R-CHOP protocol; D000069283:Rituximab; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; C503535:DPP6 protein, human; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D011241:Prednisone