title: Selective Serotonin Reuptake Inhibitors and Night Sweats in a Primary Care Population.
abstract: OBJECTIVE
  Several small published case reports have suggested that selective serotonin reuptake inhibitors (SSRIs) can cause night sweats. The purpose of this study was to investigate this possibility further and to explore possible associations between night sweats and other commonly prescribed medications.
  
  
  METHODS
  Cross-sectional, secondary data analysis.
  
  
  METHODS
  Data were obtained during the Oklahoma Longitudinal Assessment of the Health Outcomes of Mature Adults, a longitudinal cohort study carried out in the Oklahoma Physicians Resource/Research Network.
  
  
  METHODS
  413 adult primary care patients aged 65-94 years.
  
  
  METHODS
  Current regular use of one of 35 classes of medication.
  
  
  METHODS
  At least moderate night sweats during the prior month.
  
  
  RESULTS
  A total of 38 (9.2 %) reported night sweats. Age, gender, body mass index, and total number of medications taken regularly were not associated with night sweats. After adjusting for age and gender, SSRIs (odds ratio [OR] 3.01; 95 % confidence interval [CI] 1.26-7.19), angiotensin receptor blockers (ARBs) (OR 3.44; 95 % CI 1.36-8.69), and thyroid hormone supplements (OR 2.53; 95 % CI 1.24-5.15) were the only classes of medications associated with night sweats.
  
  
  CONCLUSIONS
  Use of SSRIs may well be associated with night sweats in older patients. Associations found between night sweats and ARBs and thyroid supplements warrant further study.
authors.affiliation: Department of Family and Preventive Medicine, College of Medicine, University of Oklahoma Health Sciences Center, 900 NE 10th Street, Oklahoma City, OK, 73104, USA. james-mold@ouhsc.edu.
authors.forename: James W
authors.initials: JW
authors.lastname: Mold
authors.affiliation: College of Nursing, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Holtzclaw