title: Kidney Tumor in a von Hippel-Lindau (VHL) Patient With Intensely Increased Activity on 68Ga-DOTA-TATE PET/CT.
abstract: Renal and pancreatic cysts and tumors are the most common visceral manifestations of von Hippel-Lindau (VHL) disease, a heritable multisystem cancer syndrome characterized by development of a variety of malignant and benign tumors. We report a case of a VHL patient with multiple renal cystic and complex cystic/solid lesions. The patient underwent Ga-DOTA-TATE-PET/CT showing intensely increased activity by a solid lesion which demonstrated enhancement on both CT and MRI scans, raising high suspicion for malignancy. The presented case indicates application of SSTR-imaging using Ga-DOTA-conjugated peptides in VHL-patients and emphasizes the need for cautious interpretation of renal parenchyma Ga-DOTATATE activity.
authors.affiliation: From the *Radiology and Imaging Sciences, Warren Grant Magnuson Clinical Center (CC), National Institutes of Health (NIH), Bethesda; †Division of Nuclear Medicine, RAD&IS, Clinical Center, National Institutes of Health (NIH), Bethesda; †Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD; §Endocrine and Thoracic Surgery, University Hospitals of Geneva, Geneva, Switzerland; and ∥Center for Research in Computer Vision (CRCV), Electrical and Computer Science Department, University of Central Florida (UCF), Orlando, FL.
authors.forename: Georgios Z
authors.initials: GZ
authors.lastname: Papadakis
authors.forename: Corina
authors.initials: C
authors.lastname: Millo
authors.forename: Samira M
authors.initials: SM
authors.lastname: Sadowski
authors.forename: Ulas
authors.initials: U
authors.lastname: Bagci
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Patronas
mesh_terms: D006801:Humans; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals; D006623:von Hippel-Lindau Disease / Q000000981:diagnostic imaging*
chemical_list: D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; C513399:gallium Ga 68 dotatate