title: 15years of progress in gestational trophoblastic disease: Scoring, standardization, and salvage.
abstract: Significant improvements in treatment and the understanding of gestational trophoblastic neoplasia have occurred in the last 15years. These diseases are almost always curable, and refractory patients have more options for salvage therapy. Recent improvements in the understanding of epidemiology, diagnosis, and cell biology have resulted in changes in staging, advances in treatment options, and opportunities for fertility preservation.
authors.affiliation: Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC, United States. Electronic address: jubilee.brown@carolinashealthcare.org.
authors.forename: Jubilee
authors.initials: J
authors.lastname: Brown
authors.affiliation: Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC, United States.
authors.forename: R Wendel
authors.initials: RW
authors.lastname: Naumann
authors.affiliation: Charing Cross Trophoblastic Disease Centre, Department of Medical Oncology, Charing Cross Campus of Imperial College London, London, United Kingdom.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Seckl
authors.affiliation: Spectrum Health Medical Group, Department of Obstetrics, Gynecology, and Womens Health Group, Grand Rapids, MI, United States.
authors.forename: Julian
authors.initials: J
authors.lastname: Schink
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005260:Female; D059247:Fertility Preservation; D031901:Gestational Trophoblastic Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007044:Hysterectomy; D011159:Population Surveillance; D011247:Pregnancy; D016879:Salvage Therapy / Q000379:methods
keywords: Choriocarcinoma; Gestational trophoblastic disease; Hydatidiform mole; Placental site trophoblastic tumor