title: Successful Corticosteroid Treatment for Purpura Fulminans Associated with Quinolone.
abstract: Purpura fulminans (PF) is a life-threatening syndrome comprising progressive hemorrhagic necrosis due to disseminated intravascular coagulation and dermal vascular thrombosis that leads to purpura and tissue necrosis. Various therapies have been used to arrest the progression of this disease, however, there is no established treatment because of the variety of underlying causes. We herein present an adult case of PF associated with leukocytoclastic vasculitis triggered by antibiotic (levofloxacin) intake. As a result of our rapid and accurate identification of the underlying cause, corticosteroid therapy successfully repressed the inflammatory process. As far as we know, this is the first report of levofloxacin-associated PF.
authors.affiliation: Division of Hematology and Stem Cell Transplantation, Shizuoka Cancer Center, Japan.
authors.forename: Ikue
authors.initials: I
authors.lastname: Okamura
authors.forename: Yukitsugu
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Yuka
authors.initials: Y
authors.lastname: Katsurada
authors.forename: Ken
authors.initials: K
authors.lastname: Sato
authors.forename: Takashi
authors.initials: T
authors.lastname: Ikeda
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Kimura
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D004211:Disseminated Intravascular Coagulation / Q000150:complications* / Q000188:drug therapy; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D064704:Levofloxacin / Q000009:adverse effects*; D008775:Methylprednisolone / Q000627:therapeutic use; D055665:Purpura Fulminans / Q000139:chemically induced* / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D005938:Glucocorticoids; D064704:Levofloxacin; D008775:Methylprednisolone