title: Carcinoma Ex Pleomorphic Adenoma of the Tongue: Difficulty in Diagnosis Between Metastasis of Breast Cancer and Salivary Tumor.
abstract: Carcinoma ex pleomorphic adenoma (CEPA) is a carcinoma that shows histologic evidence of arising in or from a benign pleomorphic adenoma. Carcinoma ex pleomorphic adenoma often occurs in parotid glands, but is extremely rarely in the tongue. A 53-year-old Japanese woman was referred to the Department of Oral and Maxillofacial Surgery, Nagasaki University Hospital, because of tumor of the right dorsum tongue. She had a history of surgery of breast cancer (invasive ductal carcinoma) and it was disseminated to the lung and bone. Macroscopic examination revealed an oval tumor with a smooth mucosal surface of 10 mm in diameter in the right dorsum tongue. A clinical diagnosis was metastasis from breast cancer or primary salivary gland tumor. Histologic diagnosis of the biopsy specimen was CEPA. She underwent partial glossectomy under general anesthesia. The final diagnosis of surgical materials was CEPA based on the differential diagnosis from breast carcinoma. She is alive bearing disseminated breast carcinoma without recurrence of CEPA at 6 months after glossectomy.
authors.affiliation: *Departments of Clinical Oral Oncology †Department of Oral Pathology and Bone Metabolism, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: Shuichi
authors.initials: S
authors.lastname: Fujita
authors.forename: Masaki
authors.initials: M
authors.lastname: Adachi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakamoto
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Naruse
authors.forename: Souichi
authors.initials: S
authors.lastname: Yanamoto
authors.forename: Toru
authors.initials: T
authors.lastname: Ikeda
authors.forename: Masahiro
authors.initials: M
authors.lastname: Umeda
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D008949:Adenoma, Pleomorphic / Q000150:complications / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis* / Q000556:secondary; D003937:Diagnosis, Differential; D005260:Female; D005927:Glossectomy; D006801:Humans; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D012468:Salivary Gland Neoplasms / Q000150:complications / Q000473:pathology*; D014062:Tongue Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology