title: Therapeutic Drug Monitoring of Anti-human Immunodeficiency Virus Drugs in a Patient with Short Bowel Syndrome.
abstract: An elderly woman with human immunodeficiency virus-1 infection developed short bowel syndrome as a result of extensive intestinal resection. Considering the possibility of poor absorption of antiretroviral drugs (ARVs), therapeutic drug monitoring (TDM) was performed. A single-dose test of 6 ARVs (darunavir, ritonavir, lopinavir, etravirine, maraviroc, and raltegravir) did not provide information on the appropriate ARV, and repeated TDM under continuous antiretroviral therapy resulted in viral suppression below 50 copies/mL, which was considered to be treatment success. These assessments suggest the importance of TDM in the steady state for the successful treatment of individuals with impaired gastrointestinal function using ARVs.
authors.affiliation: AIDS Medical Center, National Hospital Organization Osaka National Hospital, Japan.
authors.forename: Motoko
authors.initials: M
authors.lastname: Ikuma
authors.forename: Dai
authors.initials: D
authors.lastname: Watanabe
authors.forename: Hiroki
authors.initials: H
authors.lastname: Yagura
authors.forename: Misa
authors.initials: M
authors.lastname: Ashida
authors.forename: Masaaki
authors.initials: M
authors.lastname: Takahashi
authors.forename: Masaaki
authors.initials: M
authors.lastname: Shibata
authors.forename: Tadafumi
authors.initials: T
authors.lastname: Asaoka
authors.forename: Munehiro
authors.initials: M
authors.lastname: Yoshino
authors.forename: Tomoko
authors.initials: T
authors.lastname: Uehira
authors.forename: Wataru
authors.initials: W
authors.lastname: Sugiura
authors.forename: Takuma
authors.initials: T
authors.lastname: Shirasaka
mesh_terms: D000368:Aged; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D003510:Cyclohexanes / Q000627:therapeutic use; D016903:Drug Monitoring; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D000077592:Maraviroc; D009570:Nitriles; D011724:Pyridazines / Q000627:therapeutic use; D011743:Pyrimidines; D019438:Ritonavir / Q000627:therapeutic use; D012778:Short Bowel Syndrome / Q000150:complications*; D014230:Triazoles / Q000627:therapeutic use
chemical_list: D019380:Anti-HIV Agents; D003510:Cyclohexanes; D009570:Nitriles; D011724:Pyridazines; D011743:Pyrimidines; D014230:Triazoles; C451734:etravirine; D000077592:Maraviroc; D019438:Ritonavir