title: Focal Therapy for Prostate Cancer: Pending Questions.
abstract: Focal therapy (FT) represents a potential shift in clinical practice by featuring a tissue-sparing approach for prostate cancer (PCa) treatment. It stands midway between active surveillance (AS) and more aggressive options like radical prostatectomy (RP) or radiotherapy. The field has enormously evolved in the last few years but there are still pending questions to answer in the future. The manuscript overlooks FT in terms of indications, available energies, situation of tumor microenvironment, follow-up, re-interventions, and the future of this approach for PCa.
authors.affiliation: Department of Urology, L'Institut Mutualiste Montsouris, 42, Bd Jourdan, 75674, Paris Cedex 14, France. xavier.cathelineau@imm.fr.
authors.forename: Xavier
authors.initials: X
authors.lastname: Cathelineau
authors.affiliation: Department of Urology, L'Institut Mutualiste Montsouris, 42, Bd Jourdan, 75674, Paris Cedex 14, France.
authors.forename: Rafael
authors.initials: R
authors.lastname: Sanchez-Salas
mesh_terms: D000359:Aftercare; D017115:Catheter Ablation / Q000379:methods*; D003452:Cryosurgery / Q000379:methods*; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D006801:Humans; D061705:Image-Guided Biopsy; D007610:Kallikreins / Q000097:blood; D008279:Magnetic Resonance Imaging; D008297:Male; D059351:Organ Sparing Treatments; D018579:Patient Selection; D011467:Prostate / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D047368:Tumor Burden; D059016:Tumor Microenvironment; D014463:Ultrasonography
chemical_list: C549870:KLK3 protein, human; D007610:Kallikreins; D017430:Prostate-Specific Antigen
keywords: Focal therapy; Prostate cancer; Radical prostatectomy; Treatment