title: Polydeoxyribonucleotide improves wound healing of fractional laser resurfacing in rat model.
abstract: BACKGROUND
  Polydeoxyribonucleotide (PDRN) is an active compound that can promote wound healing. PDRN stimulates wound healing by enhancing angiogenesis and increasing fibroblast growth rates. Laser skin resurfacing is a popular cosmetic procedure for skin rejuvenation. Despite excellent improvement of photo-damaged skin and acne scarring, it is accompanied with drawbacks, such as prolonged erythema and crusting.
  
  
  OBJECTIVE
  This study was designed to assess the effect of PDRN on wounds induced by fractional laser resurfacing.
  
  
  METHODS
  Twelve male rats aged 8 weeks were randomly assigned to the PDRN treatment group and the control group. Wounds were induced using a fractional ablative CO2laser. The treatment group received daily injections of PDRN and the control group received injections of the vehicle. Wound healing assessed by clinical features and histopathologic findings.
  
  
  RESULTS
  The process of wound healing was faster in the treatment group than in the control group. In the histopathological examination, the granulation tissue thickness score of the treatment group was significantly higher than that of the control group. Results of immunohistochemical staining showed a marked increase of VEGF-positive cells and PECAM-1/CD31-positive microvessels in the treatment group.
  
  
  CONCLUSIONS
  PDRN may be a beneficial option to promote wound healing after laser treatment.
authors.affiliation: a Graduate School, The Catholic University of Korea , Seoul , the Republic of Korea.
authors.forename: Mi
authors.initials: M
authors.lastname: Yu
authors.affiliation: b Department of Dermatology , Seoul St. Mary's Hospital , Seoul , Republic of Korea.
authors.forename: Jun Young
authors.initials: JY
authors.lastname: Lee
mesh_terms: D000818:Animals; D003357:Cosmetic Techniques / Q000009:adverse effects*; D020405:Dermis / Q000187:drug effects / Q000293:injuries; D004817:Epidermis / Q000187:drug effects / Q000293:injuries; D053685:Laser Therapy / Q000009:adverse effects; D054020:Lasers, Gas / Q000009:adverse effects*; D008297:Male; D011089:Polydeoxyribonucleotides / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012060:Rejuvenation; D015595:Skin Aging; D012879:Skin Physiological Phenomena / Q000187:drug effects*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D011089:Polydeoxyribonucleotides
keywords: Cosmeceuticals; Lasers and light sources