title: Impact of weight loss-associated changes in detailed body composition as assessed by whole-body MRI on plasma insulin levels and homeostatis model assessment index.
abstract: We assessed the effect of weight loss-associated changes in detailed body composition on plasma insulin levels and homeostatic model assessment (HOMA) index to calculate the magnitude of reduction in different adipose tissue depots required to improve insulin sensitivity.
  
  
  
  A total of 50 subjects aged 20-69 years were studied. The participants were compiled from low-calorie diet interventions and bariatric surgery and differed in their baseline body mass index (BMI; range 21.6-54.4 kg/m2) and degree of weight losses (range -3.3 to -56.9 kg). Detailed body composition and liver fat were measured using whole-body magnetic resonance imaging (MRI). Insulin resistance was assessed by HOMA.
  
  
  
  Mean body weight decreased by -16.0±13.6 kg. Significant changes were observed in total adipose tissue (TATMRI, range -0.5 to -36.0 kg), total subcutaneous adipose tissue (SATMRI), visceral adipose tissue (VATMRI), skeletal muscle, liver fat, plasma insulin levels and HOMA. Decreases in insulin and HOMA were correlated with reductions in TATMRI, SATMRI, VATMRI(just with HOMA) and liver fat. Losses of 2.9 and 6.5 kg body weight, 2.0 and 5.0 kg TATMRIas well as 1.6 and 6% liver fat were required to decrease plasma insulin levels by 1 μU/ml and HOMAadjusted for baseline HOMAby 1 point. Multiple regression analysis showed that baseline liver fat and changes in liver fat explained 49.7% and 55.1% of the variance in weight loss-associated changes in plasma insulin and HOMA, respectively.
  
  
  
  Decreases of adipose tissues and liver fat are the major determinants of reduction in plasma insulin levels and improvement in HOMA index.
authors.affiliation: Institute for Human Nutrition and Food Science, University of Kiel, Kiel, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Pourhassan
authors.affiliation: Klinik für Diagnostische Radiologie, Sektion Biomedizinische Bildgebung, Kiel, Germany.
authors.forename: C-C
authors.initials: CC
authors.lastname: Glüer
authors.affiliation: Asklepios West-Klinikum, Hamburg, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Pick
authors.affiliation: Asklepios West-Klinikum, Hamburg, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Tigges
authors.affiliation: Institute for Human Nutrition and Food Science, University of Kiel, Kiel, Germany.
authors.forename: M J
authors.initials: MJ
authors.lastname: Müller
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging / Q000503:physiopathology; D050154:Adiposity / Q000502:physiology; D000328:Adult; D000368:Aged; D050110:Bariatric Surgery; D001823:Body Composition / Q000502:physiology*; D031204:Caloric Restriction; D005260:Female; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000000981:diagnostic imaging / Q000628:therapy; D011184:Postoperative Period; D015431:Weight Loss / Q000502:physiology*; D051598:Whole Body Imaging / Q000379:methods; D055815:Young Adult
chemical_list: D007328:Insulin