title: Human cytomegalovirus infection and colorectal cancer risk: a meta-analysis.
abstract: Human cytomegalovirus infection (HCMV) has been recently considered as a factor for tumorigenesis. The current study used meta-analytical techniques to explore the prevalence of HCMV in tumor tissues and the relationship between human cytomegalovirus and colorectal cancer (CRC) risk. 11 studies detecting HCMV DNA in tumor tissues were included in meta-analysis. The prevalence rate and odds ratio (OR) were two main parameters. The overall prevalence of human cytomegalovirus DNA in tumor tissues were 27.5% (95% CI = 17.2%-37.8%). Binary logistic regression showed that the studies reported before 2010 involving formalin-fixed specimens from patients in developed region represented a lower proportion of HCMV. The tumor tissues had a significantly higher rate of virus infection compared with normal tissues (OR = 6.59, 95% CI = 4.48-9.69, I2 = 0%, P = 0.71). Subgroup analysis revealed the prevalence of the virus didn't differ in patients with different tumor stages, in tumor cells with different histologic grades, also in different kinds of specimen (polyp and adenocarcinoma). The results of current study suggested a statistically association between the virus infection and an increased risk of colorectal cancer.
authors.affiliation: Department of Colorectal Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.|Key Laboratory of Biotherapy of Zhejiang province, Hangzhou, China.
authors.forename: Bingjun
authors.initials: B
authors.lastname: Bai
authors.affiliation: Department of Colorectal Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.|Key Laboratory of Biotherapy of Zhejiang province, Hangzhou, China.
authors.forename: Xingxing
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Colorectal Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.|Key Laboratory of Biotherapy of Zhejiang province, Hangzhou, China.
authors.forename: Engeng
authors.initials: E
authors.lastname: Chen
authors.affiliation: Department of Colorectal Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.|Key Laboratory of Biotherapy of Zhejiang province, Hangzhou, China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Zhu
mesh_terms: D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D003587:Cytomegalovirus; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000821:virology; D006801:Humans; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D016017:Odds Ratio; D015995:Prevalence; D012306:Risk
keywords: HCMV; colorectal cancer; meta-analysis; tumor progression; viral DNA