title: Portable Device for Measuring Breath Acetone Based on Sample Preconcentration and Cavity Enhanced Spectroscopy.
abstract: A portable and compact device is demonstrated for measuring acetone in breath samples. The device features a 7 cm long high finesse optical cavity as an optical sensor that is coupled to a miniature adsorption preconcentrator containing 0.5 g of polymer material. Acetone is trapped out of breath and released into the optical cavity where it is probed by a near-infrared diode laser operating at ∼1670 nm. With an optical cavity mirror reflectivity of 99.994%, a limit of detection of 159 ppbv (1σ) is demonstrated on samples from breath bags. Initial results on direct breath sampling are presented with a precision of 100 ppbv. The method is validated with measurements made using an ion-molecule reaction mass spectrometer. Data are presented on elevated breath acetone from two individuals following an overnight fast and exercise, and from a third individual during several days of routine behavior.
authors.affiliation: Oxford Medical Diagnostics, Ltd. , Centre for Innovation and Enterprise, Begbroke Science Park, Begbroke Hill, Begbroke OX5 1PF, United Kingdom.
authors.forename: Thomas P J
authors.initials: TP
authors.lastname: Blaikie
authors.forename: John
authors.initials: J
authors.lastname: Couper
authors.forename: Gus
authors.initials: G
authors.lastname: Hancock
authors.forename: Philip L
authors.initials: PL
authors.lastname: Hurst
authors.forename: Robert
authors.initials: R
authors.lastname: Peverall
authors.forename: Graham
authors.initials: G
authors.lastname: Richmond
authors.forename: Grant A D
authors.initials: GA
authors.lastname: Ritchie
authors.affiliation: Oxford Medical Diagnostics, Ltd. , Centre for Innovation and Enterprise, Begbroke Science Park, Begbroke Hill, Begbroke OX5 1PF, United Kingdom.
authors.forename: David
authors.initials: D
authors.lastname: Taylor
authors.forename: Kevin
authors.initials: K
authors.lastname: Valentine
mesh_terms: D000096:Acetone / Q000032:analysis*; D053000:Analytic Sample Preparation Methods; D001944:Breath Tests / Q000295:instrumentation*; D006801:Humans; D013057:Spectrum Analysis / Q000295:instrumentation / Q000379:methods*
chemical_list: D000096:Acetone