title: Two Bugs a NOD Away from Improving Cancer Therapy Efficacy.
abstract: It has recently become apparent that the gut microbiota modulates the response to cancer therapy. In this issue of Immunity, Daillère et al. (2016) identified two bacterial species potentiating the anti-tumor effect of cyclophosphamide that are kept in check by the sensor NOD2.
authors.affiliation: Inflammatory Cell Dynamics Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
authors.forename: Romina E
authors.initials: RE
authors.lastname: Araya
authors.affiliation: Inflammatory Cell Dynamics Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address: rgoldszmid@mail.nih.gov.
authors.forename: Romina S
authors.initials: RS
authors.lastname: Goldszmid
mesh_terms: D000818:Animals; D006801:Humans; D001419:Bacteria / Q000378:metabolism; D003520:Cyclophosphamide / Q000494:pharmacology / Q000627:therapeutic use; D000069196:Gastrointestinal Microbiome / Q000502:physiology; D009369:Neoplasms / Q000188:drug therapy / Q000382:microbiology; D053473:Nod2 Signaling Adaptor Protein / Q000378:metabolism
chemical_list: D003520:Cyclophosphamide; D053473:Nod2 Signaling Adaptor Protein