title: Lifestyle and vitamin D dosage in women with breast cancer.
abstract: BACKGROUND
  The prevention strategy of breast cancer is still the key factor for early diagnosis and the most effective method for tracking the disease.
  
  
  OBJECTIVE
  This study aimed to evaluate the association vitamin D level with breast cancer in women.
  
  
  METHODS
  This hospital case-control study was conducted with 181 women with breast cancer and 197 healthy controls. Vitamin D status, calcium, phosphorus and PTH serum dosage and data collection related to lifestyle and patient's history, besides anthropometric measurements were performed. Univariate analysis (Chi-square and raw odds ratio) and multivariate analysis were performed through multivariate logistic regression.
  
  
  RESULTS
  This study shows a higher value of vitamin D in health controls (26.9 mg/dL) than in breast cancer women (24.8 mg/dL). Higher numbers of women with sufficient vitamin D status (34.85%) were found in control group than cancer group. Using the multiple logistic regression model, the family history of breast cancer (OR 36.37, 95%CI 4.75-278.50) and menopause (OR 5.17, 95% CI 2.72-9.80) had a direct association with breast cancer, while the level of vitamin D (OR 0.95, 95%CI 0.91-0.99) and moderate physical activity (OR 0.31, 95%CI 0.10-0.93) maintained the inverse associations with the disease.
  
  
  CONCLUSIONS
  Vitamin D status and the practice of moderate physical activity were considered protective factors for breast cancer. However, menopause and family history of breast cancer were considered a risk factor for breast cancer.
authors.affiliation: Department of Nutrition and Health. Laboratory of Nutrition Biochemistry. Federal University of Viçosa. University Campus, Viçosa, Brazil. Department of Nursing and Medicine. Federal University of Viçosa. University Campus. Viçosa. mcgpeluzio@gmail.com.
authors.forename: Catarina Maria
authors.initials: CM
authors.lastname: Oliveira Sediyama
authors.forename: Manoela Maciel Dos Santos
authors.initials: MM
authors.lastname: Dias
authors.forename: Milene Cristine
authors.initials: MC
authors.lastname: Pessoa
authors.forename: Andréia Ribeiro
authors.initials: AR
authors.lastname: Queiroz
authors.forename: Lara Gomes
authors.initials: LG
authors.lastname: Suhett
authors.forename: Renata Nascimento
authors.initials: RN
authors.lastname: Freitas
authors.forename: Sérgio Oliveira
authors.initials: SO
authors.lastname: De Paula
authors.forename: Maria do Carmo Gouveia
authors.initials: MD
authors.lastname: Peluzio
mesh_terms: D001938:Brazil / Q000453:epidemiology; D001943:Breast Neoplasms / Q000453:epidemiology*; D002136:Calcium, Dietary; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008019:Life Style; D008875:Middle Aged; D012959:Socioeconomic Factors; D014807:Vitamin D / Q000008:administration & dosage*; D014815:Vitamins / Q000008:administration & dosage*
chemical_list: D002136:Calcium, Dietary; D014815:Vitamins; D014807:Vitamin D
keywords: Breast cancer.  Vitamin D.  Menopause. Physical  activity. Case-control  study.