title: Evaluation of wound healing treated with latex derived from rubber trees and Aloe Vera extract in rats.
abstract: To compare the use of latex derivative and Aloe vera extract to wound healing.
  Twenty one rats were randomly divided into three groups and each one had a wound made by incision. The treatment consisted in: derivative of latex (GL), Aloe vera extract (GA) and saline solution (GC). The wound area was measured on the 7th, 14th and 21st days and macroscopic and microscopic evaluation were done.
  The comparison between the measurements of the wounds presented statistical difference in GC and GA from the 7th day of evaluation and GL from the 14th day. The extent of the wound was significantly smaller by the 7th day in GL. Histologically, in GL, the neovascularization was significant on the 7th, 14th and 21st days. On the 21st day the scar was large and little mature. In GA and GC, the findings were similar on the 7th, 14th and 21st days with a slight better organization of skin and collagen on the 21st in GA.
  Statistical analysis did not allow for the definition of the best topical agent. The latex had the highest angiogenesis, but a possible foreign body granuloma. Aloe vera has revealed a healing process adequated temporally in histology.
authors.affiliation: PhD, Associate Professor, Laboratory of Surgical Technique, School of Medical Sciences, Pharmaceutical and Biomedical, Pontificia Universidade Católica de Goiás (PUC-Goiás), Goiania-GO, Brazil. Intellectual, scientific and design of the study; acquisition and interpretation of data; technical procedures; critical revision; supervised all phases of the study.
authors.forename: Marcelo Luiz
authors.initials: ML
authors.lastname: Brandão
authors.affiliation: PhD, Associate Professor, Master's Program in Environmental Sciences and Health, School of Medical Sciences, Pharmaceutical and Biomedical, PUC-Goiás, Goiania-GO, Brazil. Intellectual, scientific and design of the study; acquisition and interpretation of data; technical procedures; critical revision.
authors.forename: Paulo Roberto Melo
authors.initials: PR
authors.lastname: Reis
authors.affiliation: Master, Fellow PhD degree, Program in Biotechnology and Biodiversity - Pro-Midwest Network, Universidade Federal de Goiás (UFG), Goiania-GO, Brazil. Acquisition of data, technical procedures.
authors.forename: Lilhian Alves de
authors.initials: LA
authors.lastname: Araújo
authors.affiliation: Graduate student, School of Medical Sciences, Pharmaceutical and Biomedical, PUC-Goiás, Goiania-GO, Brazil. Acquisition, analysis and interpretation of data; statistical analysis; technical procedures; manuscript preparation.
authors.forename: Ana Carolina Vicente
authors.initials: AC
authors.lastname: Araújo
authors.affiliation: Graduate student, School of Medical Sciences, Pharmaceutical and Biomedical, PUC-Goiás, Goiania-GO, Brazil. Acquisition, analysis and interpretation of data; statistical analysis; technical procedures; manuscript preparation.
authors.forename: Maisa Helena de Abreu Silva
authors.initials: MH
authors.lastname: Santos
authors.affiliation: PhD, Class A Professor, General Pathology, Tropical Institute of Pathology and Public Health, UFG, Goiania-GO, Brazil. Technical procedures, analysis and interpretation of data, statistical analysis, manuscript preparation, critical revision.
authors.forename: Marina Pacheco
authors.initials: MP
authors.lastname: Miguel
mesh_terms: D000504:Aloe / Q000737:chemistry*; D000818:Animals; D004353:Drug Evaluation, Preclinical; D028482:Hevea / Q000737:chemistry*; D007840:Latex / Q000737:chemistry / Q000627:therapeutic use*; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D011897:Random Allocation; D017208:Rats, Wistar; D012965:Sodium Chloride / Q000008:administration & dosage; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D007840:Latex; D010936:Plant Extracts; D012965:Sodium Chloride