title: Analysis of Cerebrospinal Fluid Pressure Estimation Using Formulae Derived From Clinical Data.
abstract: OBJECTIVE
  To evaluate a frequently used regression model and a new, modified regression model to estimate cerebrospinal fluid pressure (CSFP).
  
  
  METHODS
  Datasets from the Beijing iCOP study from Tongren Hospital, Beijing, China, and the Mayo Clinic, Rochester, Minnesota, were tested in this retrospective, case-control study. An often-used regression model derived from the Beijing iCOP dataset, but without radiographic data, was used to predict CSFP by using demographic and physiologic data. A regression model was created using the Mayo Clinic dataset and tested against a validation group. The Mayo Clinic-derived formula was also tested against the Beijing Eye Study population. Intraclass correlation was used to assess predicted versus actual CSFP.
  
  
  RESULTS
  The Beijing-derived regression equation was reported to have an intraclass correlation coefficient (ICC) of 0.71, indicating strong correlation between predicted and actual CSFP in the study population. The Beijing iCOP regression model poorly predicted CSFP in the Mayo Clinic population with an ICC of 0.14. The Mayo Clinic-derived regression model similarly did not predict CSFP in its Mayo Clinic validation group (ICC 0.28 ± 0.04) nor in the Beijing Eye Study population (ICC 0.06).
  
  
  CONCLUSIONS
  Formulae used to predict CSFP derived from clinical data fared poorly against a large retrospective dataset. This may be related to differences in lumbar puncture technique, in the populations tested, or the timing of collection of physiologic variables in the Mayo Clinic dataset. Caution should be used when interpreting results based on formulaic derivation of CSFP.
authors.affiliation: University of North Carolina, Chapel Hill, North Carolina, United States.
authors.forename: David
authors.initials: D
authors.lastname: Fleischman
authors.affiliation: Wilmer Eye Institute, Baltimore, Maryland, United States.
authors.forename: Amanda K
authors.initials: AK
authors.lastname: Bicket
authors.affiliation: Duke University Eye Center, Durham, North Carolina, United States.
authors.forename: Sandra S
authors.initials: SS
authors.lastname: Stinnett
authors.affiliation: Vance Thompson Vision, Sioux Falls, South Dakota, United States.
authors.forename: John P
authors.initials: JP
authors.lastname: Berdahl
authors.affiliation: Ruprecht-Karls University, Heidelberg, Germany.
authors.forename: Jost B
authors.initials: JB
authors.lastname: Jonas
authors.affiliation: Beijing Tongren Eye Hospital, Beijing, China.
authors.forename: Ning Li
authors.initials: NL
authors.lastname: Wang
authors.affiliation: Mayo Clinic, Rochester, Minnesota, United States.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Fautsch
authors.affiliation: Duke University Eye Center, Durham, North Carolina, United States.
authors.forename: R Rand
authors.initials: RR
authors.lastname: Allingham
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015170:Cerebrospinal Fluid Pressure / Q000502:physiology*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012189:Retrospective Studies; D013129:Spinal Puncture; D055815:Young Adult