title: Adipose tissue stromal vascular fraction in the treatment of full thickness burns in rats.
abstract: To analyze the healing effects of stromal vascular fraction (SVF) application compared to wound dressing with 2% silver sulfadiazine in full thickness burn wounds in rats.
  Animals were divided into two groups: 2% silver sulfadiazine group and SVF group. Both groups received occlusive bandages while the first one was treated with 2% silver sulfadiazine and the latter was treated with injections of SVF prepared from adipose tissue extracted from an animal donor. The animals were accompanied through 3, 7 and 30 days for evaluation of macroscopic, microscopic and morphometric aspects.
  On day three, a significant increase (p<0.05) of infiltration of polymorphonuclear, fibrin formation and fibroblasts migration in SVF group was observed. On the 7th day the mononuclear infiltrate, angiogenesis, collagen and fibroblasts were significantly increased in the SVF group (p<0.05). At 30 days significantly increased collagen deposition was observed in the SVF group (p<0.05) .
  Adipose tissue derived stromal vascular fraction injections promotes better wound repair than 2% silver sulfadiazine in the treatment of full thickness burn in rats during the evaluated experimental period.
authors.affiliation: Fellow Master degree, Faculty of Medicine, Universidade Federal de Goiás (UFG), Goiania-GO, Brazil. Intellectual and scientific content of the study, conception and design of the study, manuscript writing.
authors.forename: Alexandre Lamaro
authors.initials: AL
authors.lastname: Cardoso
authors.affiliation: PhD, Full Professor, Faculty of Nursing UFG, Goiania-GO, Brazil. Acquisition, analysis and interpretation of data.
authors.forename: Maria Márcia
authors.initials: MM
authors.lastname: Bachion
authors.affiliation: PhD, Associate Professor, Faculty of Medicine, UFG, Goiania-GO, Brazil. Acquisition, analysis and interpretation of data.
authors.forename: Júlia de Miranda
authors.initials: JM
authors.lastname: Morais
authors.affiliation: PhD, Full Professor, ESEFFEGO, Universidade Estadual de Goiás (UEG), Goiania-GO, Brazil. Acquisition, analysis and interpretation of data.
authors.forename: Marcelo Silva
authors.initials: MS
authors.lastname: Fantinati
authors.affiliation: Biomedic, Institute of Tropical Pathology and Public Health, Experimental Pathology Laboratory, UFG, Goiania-GO, Brazil. Acquisition of data.
authors.forename: Vera Lúcia Lima de
authors.initials: VL
authors.lastname: Almeida
authors.affiliation: PhD, Associate Professor, Institute of Tropical Pathology and Public Health, Experimental Pathology Laboratory, UFG, Goiania-GO, Brazil. Scientific and intellectual content of the study, analysis and interpretation of data, statistical analysis, manuscript preparation.
authors.forename: Ruy Souza
authors.initials: RS
authors.lastname: Lino
mesh_terms: D000273:Adipose Tissue / Q000166:cytology / Q000637:transplantation*; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D001458:Bandages; D002056:Burns / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D004195:Disease Models, Animal; D008297:Male; D008853:Microscopy; D017208:Rats, Wistar; D012837:Silver Sulfadiazine / Q000008:administration & dosage*; D017154:Stromal Cells / Q000166:cytology / Q000637:transplantation; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000891:Anti-Infective Agents, Local; D012837:Silver Sulfadiazine