title: TET enzymes as oxygen-dependent tumor suppressors: exciting new avenues for cancer management.
authors.affiliation: Vesalius Research Center, VIB, 3000 Leuven, Belgium.|Department of Oncology, Laboratory of Translational Genetics, KU Leuven, 3000 Leuven, Belgium.
authors.forename: Bernard
authors.initials: B
authors.lastname: Thienpont
authors.affiliation: Vesalius Research Center, VIB, 3000 Leuven, Belgium.|Department of Oncology, Laboratory of Translational Genetics, KU Leuven, 3000 Leuven, Belgium.
authors.forename: Eva
authors.initials: E
authors.lastname: Galle
authors.affiliation: Vesalius Research Center, VIB, 3000 Leuven, Belgium.|Department of Oncology, Laboratory of Translational Genetics, KU Leuven, 3000 Leuven, Belgium.
authors.forename: Diether
authors.initials: D
authors.lastname: Lambrechts
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D049308:Dioxygenases / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D006899:Mixed Function Oxygenases / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics / Q000628:therapy; D010100:Oxygen / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; D025521:Tumor Suppressor Proteins; D006899:Mixed Function Oxygenases; C462539:TET1 protein, human; C578792:TET3 protein, human; D049308:Dioxygenases; C541081:TET2 protein, human; D010100:Oxygen
keywords: TET1; TET2; TET3; antiangiogenic therapy; epigenetic therapy; hypermethylation; hypoxia; oncogenesis; oxygen sensitivity; tumor suppressor genes