title: Adverse Reactions to Contrast Material: A Canadian Update.
abstract: Imaging techniques frequently employ contrast agents to improve image resolution and enhance pathology detection. These gadolinium- and iodine-based media, although generally considered safe, are associated with a number of adverse effects ranging from mild to severe. Reactions are classified as either anaphylactoid ("anaphylaxis-like") or nonanaphylactoid, depending on a number of elements that will be reviewed. Herein, we have summarized predisposing risk factors for adverse events resulting from the use of contrast, their associated pathophysiological mechanisms as well as known prophylaxis for the antitreatment of high-risk patients. In the unlikely event that a serious adverse reaction does occur, we have provided a comprehensive summary of treatment protocols. Our goal was to thoroughly evaluate the current literature regarding adverse reactions to radiocontrast agents and provide an up to date review for the health care provider.
authors.affiliation: Faculty of Medicine, Dalhousie Medical School, Halifax, Nova Scotia, Canada.
authors.forename: Alexander
authors.initials: A
authors.lastname: Morzycki
authors.affiliation: Department of Anesthesia, University Health Network, Toronto, Ontario, Canada.
authors.forename: Anuj
authors.initials: A
authors.lastname: Bhatia
authors.affiliation: Joint Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada. Electronic address: kieran.murphy@uhn.ca.
authors.forename: Kieran J
authors.initials: KJ
authors.lastname: Murphy
mesh_terms: D002170:Canada; D003287:Contrast Media / Q000009:adverse effects*; D003952:Diagnostic Imaging; D064420:Drug-Related Side Effects and Adverse Reactions / Q000209:etiology / Q000628:therapy; D006801:Humans; D012307:Risk Factors
chemical_list: D003287:Contrast Media
keywords: Contrast reactions; Management; Premedication