title: [Prevalence and prognosis of aspirin resistance in critical limb ischemia patients].
abstract: OBJECTIVE
  To assess the prevalence and the association between aspirin resistance in critical limb ischemia patients using the VerifyNow®bed-side platelet test, and occurrence of cardiovascular morbidity and/or death at one year.
  
  
  METHODS
  National multicenter prospective observational study related to COPART II centers. From 2010 through 2014, 64 subjects hospitalized for critical limb ischemia and already treated by aspirin before the VerifyNow®test were included. A VerifyNow®test>550 ARU was defined as aspirin resistance. Critical limb ischemia was defined according to the TASC I criteria. The primary outcome was a composite including death, acute coronary syndrome, stroke and major amputation during the one-year follow-up period.
  
  
  RESULTS
  In all, 9/64 patients were aspirin resistant, the status was confirmed in one case. The prevalence of aspirin resistance was 14.06%. There was no significant difference between aspirin resistant and aspirin non-resistant groups in terms of cardiovascular history and glycemia status. Neither was there significant difference between the two groups in terms of survival.
  
  
  CONCLUSIONS
  Aspirin resistance was not predictive of poorer survival in critical limb ischemia patients. However, our population was limited. Considering that a clear definition of aspirin resistance and standardized diagnostic tests are lacking, complementary studies might be useful.
authors.affiliation: Service chirurgie thoracique et cardiovasculaire et angiologie, unité de médecine vasculaire, CHU de Limoges, 2, avenue Martin-Luther-King, 87000 Limoges, France. Electronic address: jeansimon.doly@gmail.com.
authors.forename: J-S
authors.initials: JS
authors.lastname: Doly
authors.affiliation: Service chirurgie thoracique et cardiovasculaire et angiologie, unité de médecine vasculaire, CHU de Limoges, 2, avenue Martin-Luther-King, 87000 Limoges, France.
authors.forename: E
authors.initials: E
authors.lastname: Lorian
authors.affiliation: Service chirurgie thoracique et cardiovasculaire et angiologie, unité de médecine vasculaire, CHU de Limoges, 2, avenue Martin-Luther-King, 87000 Limoges, France.
authors.forename: I
authors.initials: I
authors.lastname: Desormais
authors.affiliation: Service chirurgie thoracique et cardiovasculaire et angiologie, unité de médecine vasculaire, CHU de Limoges, 2, avenue Martin-Luther-King, 87000 Limoges, France.
authors.forename: J
authors.initials: J
authors.lastname: Constans
authors.affiliation: Service chirurgie thoracique et cardiovasculaire et angiologie, unité de médecine vasculaire, CHU de Limoges, 2, avenue Martin-Luther-King, 87000 Limoges, France.
authors.forename: A
authors.initials: A
authors.lastname: Bura Rivière
authors.affiliation: Service chirurgie thoracique et cardiovasculaire et angiologie, unité de médecine vasculaire, CHU de Limoges, 2, avenue Martin-Luther-King, 87000 Limoges, France.
authors.forename: P
authors.initials: P
authors.lastname: Lacroix
mesh_terms: D054058:Acute Coronary Syndrome / Q000453:epidemiology; D000368:Aged; D000369:Aged, 80 and over; D000671:Amputation, Surgical; D001241:Aspirin / Q000627:therapeutic use*; D004351:Drug Resistance; D005121:Extremities / Q000098:blood supply*; D005260:Female; D006801:Humans; D007511:Ischemia / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D020521:Stroke / Q000453:epidemiology; D016896:Treatment Outcome
chemical_list: D001241:Aspirin
keywords: Artériopathie oblitérante des membres inférieurs; Aspirin resistance; COPART; Critical limb ischemia; Ischémie critique des membres inférieurs; Peripheral arterial disease; Résistance à l’aspirine; VerifyNow(®) Aspirin