title: Osmidrosis Treatment Approaches: A Systematic Review and Meta-Analysis.
abstract: BACKGROUND
  There are many treatment modalities associated with osmidrosis. The purpose of this study was to identify and compare effective osmidrosis treatments.
  
  
  METHODS
  A systematic literature review and meta-analysis were performed using MEDLINE, EMBASE, and Cochrane databases. The osmidrosis treatment modalities were extracted as predictor variables, and recurrence and complications were extracted as outcome variables. Subgroup analysis was performed with regard to combined curettage, and fixed and random effect models were applied.
  
  
  RESULTS
  Forty studies published prior to February 2016 were identified. The group that received surgery had the lowest incidence of recurrence as 3.0%, followed by the liposuction and laser groups (5.5%, 8.2%, respectively). The liposuction group had the lowest incidence of complications (hematoma, 1.6%; necrosis, 1.5%), followed by the surgery (hematoma, 1.9%; necrosis, 2.1%) and laser groups (hematoma, 3.1%; necrosis, 4.5%). When combining curettage, the recurrence rate was lower in the surgery (P = 0.06) and liposuction groups (P < 0.01).
  
  
  CONCLUSIONS
  Surgery treatment has been demonstrated as the most effective result for treating osmidrosis. Liposuction has been identified as the most effective treatment, with the lowest number of associated complications. Combining the curettage method was an effective option for lowering recurrence rate in surgery and liposuction treatments. Finally, laser treatment was not significantly associated with benefits.
authors.affiliation: From the *Department of Plastic and Reconstructive Surgery, Medical School of Chonbuk National University; and †Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeounju, Republic of Korea.
authors.forename: Jin Yong
authors.initials: JY
authors.lastname: Shin
authors.forename: Si-Gyun
authors.initials: SG
authors.lastname: Roh
authors.forename: Nae-Ho
authors.initials: NH
authors.lastname: Lee
authors.forename: Kyung-Moo
authors.initials: KM
authors.lastname: Yang
mesh_terms: D001365:Axilla; D003131:Combined Modality Therapy; D003475:Curettage; D006801:Humans; D053685:Laser Therapy; D015187:Lipectomy; D015233:Models, Statistical; D009812:Odorants; D013543:Sweat Gland Diseases / Q000628:therapy*; D016896:Treatment Outcome