title: Effect of Resected Gastric Volume on Ghrelin and GLP-1 Plasma Levels: a Prospective Study.
abstract: The correlation between resected gastric volume (RGV) and neuro-humoral changes (ghrelin and GLP-1) after laparoscopic sleeve gastrectomy (LSG) and their effects on type 2 diabetes mellitus (T2DM) has been evaluated.
  
  
  
  Ninety-eight patients were divided in two groups: RGV <1200 mL (group A: 53 pts) and RGV >1200 mL (group B: 45 pts). Insulin secretion (insulin area under the curve (AUC)), insulinogenic index (IGI) and insulin-resistance (homeostasis model assessment, HOMAIR) were assessed before and after surgery (at the 3rd day and 6, 12 and 24 months after LSG) using the oral glucose tolerance test (OGTT). At the same time, ghrelin and GLP-1 levels were determined.
  
  
  
  A significant difference in T2DM resolution rate was observed after 6, 12 and 24 months in favour of RGV >1200 mL. Group B performed better than group A at the 3rd day and at the 6th, 12th and 24th months with regard to AUC, IGI and HOMAIR. In both groups, OGTT resulted in decreased ghrelin values and a significant increase in GLP-1 values for group B at the 3rd day and at the 6th and 12th months with no difference at the 24th month.
  
  
  
  Ghrelin and GLP-1 changes play a role in the regulation of glucose metabolism during the 1st year after LSG. RGV influences ghrelin and GLP-1 plasma levels after LSG, with a significant improvement in the T2DM control.
authors.affiliation: Dipartimento di Scienze Cliniche Applicate e Biotecnologie (DISCAB)-Ospedale civile San Salvatore, University of L'Aquila, L'Aquila, Italy. silversista@gmail.com.|Dipartimento di Scienze Cliniche Applicate e Biotecnologie (DISCAB) - Ospedale civile San Salvatore, University of L'Aquila, Presso Ospedale S. Salvatore, Edificio Delta 6, 67100, Coppito, AQ, Italy. silversista@gmail.com.
authors.forename: Federico
authors.identifier: 0000-0002-2149-0876
authors.initials: F
authors.lastname: Sista
authors.affiliation: Dipartimento di Scienze Cliniche Applicate e Biotecnologie (DISCAB)-Ospedale civile San Salvatore, University of L'Aquila, L'Aquila, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Abruzzese
authors.affiliation: Dipartimento di Scienze Cliniche Applicate e Biotecnologie (DISCAB)-Ospedale civile San Salvatore, University of L'Aquila, L'Aquila, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Clementi
authors.affiliation: Service de Chirurgie Digestive-Hôpital Avicenne, Université Paris XIII, Bobigny, France.
authors.forename: Sergio
authors.initials: S
authors.lastname: Carandina
authors.affiliation: Dipartimento di Scienze Cliniche Applicate e Biotecnologie (DISCAB)-Ospedale civile San Salvatore, University of L'Aquila, L'Aquila, Italy.
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Amicucci
mesh_terms: D000328:Adult; D050110:Bariatric Surgery; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D005260:Female; D005743:Gastrectomy / Q000379:methods; D054439:Ghrelin / Q000097:blood*; D052216:Glucagon-Like Peptide 1 / Q000097:blood*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism; D007333:Insulin Resistance; D000078790:Insulin Secretion; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000150:complications / Q000601:surgery; D009929:Organ Size; D011184:Postoperative Period; D057234:Preoperative Period; D011446:Prospective Studies; D013270:Stomach / Q000473:pathology* / Q000601:surgery*
chemical_list: D054439:Ghrelin; D007328:Insulin; D052216:Glucagon-Like Peptide 1
keywords: Bariatric surgery; Diabetes mellitus type 2; Obesity; Sleeve gastrectomy; Volume resected