title: Altered glucose profiles and risk for hypoglycaemia during oral glucose tolerance testing in pregnancies after gastric bypass surgery.
abstract: A history of gastric bypass surgery can influence the results of the OGTT recommended during pregnancy. Therefore, we compared OGTT glucose kinetics and pregnancy outcome between pregnant gastric bypass patients and BMI-matched, lean and obese controls.
  
  
  
  Medical records were used to collect data on glucose measurements during the 2 h 75 g OGTT as well as on pregnancy and fetal outcome for 304 women (n = 76 per group, matched for age and date of delivery).
  
  
  
  Women after bariatric surgery had lower fasting glucose levels compared with lean, obese and BMI-matched controls, and showed altered postprandial glucose kinetics, including a rise at 60 min followed by hypoglycaemia with serum glucose of <3.34 mmol/l (which occurred in 54.8%). Moreover, their risk of pre-eclampsia or gestational hypertension was reduced, with an increased risk of delivering small for gestational age infants.
  
  
  
  Alternative strategies to accurately define impaired glucose metabolism in pregnancies after bariatric surgery should be explored.
authors.affiliation: Department of Obstetrics and Gynaecology, Division of Obstetrics and Feto-maternal Medicine, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Feichtinger
authors.affiliation: Department of Obstetrics and Gynaecology, Division of Obstetrics and Feto-maternal Medicine, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria.
authors.forename: Tina
authors.initials: T
authors.lastname: Stopp
authors.affiliation: Department of Obstetrics and Gynaecology, Division of Obstetrics and Feto-maternal Medicine, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria.
authors.forename: Sandra
authors.initials: S
authors.lastname: Hofmann
authors.affiliation: Department of Obstetrics and Gynaecology, Division of Obstetrics and Feto-maternal Medicine, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Springer
authors.affiliation: Department of Obstetrics and Gynaecology, Division of Obstetrics and Feto-maternal Medicine, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria.
authors.forename: Sophie
authors.initials: S
authors.lastname: Pils
authors.affiliation: Department of Internal Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Kautzky-Willer
authors.affiliation: Department of Obstetrics and Gynaecology, Division of Obstetrics and Feto-maternal Medicine, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria.
authors.forename: Herbert
authors.initials: H
authors.lastname: Kiss
authors.affiliation: Department of Obstetrics and Gynaecology, Division of Obstetrics and Feto-maternal Medicine, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Eppel
authors.affiliation: Metabolic Unit, Institute of Neuroscience, National Research Council, Padua, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Tura
authors.affiliation: Department of Internal Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria.
authors.forename: Latife
authors.initials: L
authors.lastname: Bozkurt
authors.affiliation: Department of Obstetrics and Gynaecology, Division of Obstetrics and Feto-maternal Medicine, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria. christian.goebl@meduniwien.ac.at.
authors.forename: Christian S
authors.initials: CS
authors.lastname: Göbl
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D005215:Fasting / Q000097:blood; D005260:Female; D015390:Gastric Bypass; D005865:Gestational Age; D005951:Glucose Tolerance Test / Q000379:methods*; D006801:Humans; D007003:Hypoglycemia / Q000097:blood* / Q000209:etiology*; D011247:Pregnancy
chemical_list: D001786:Blood Glucose
keywords: Bariatric surgery; Hypoglycaemia; OGTT; Pre-eclampsia; Pregnancy