title: Effect of orlistat alone or in combination withGarcinia cambogiaon visceral adiposity index in obese patients.
abstract: OBJECTIVE
  The objective of this study was to estimate the effect of orlistat alone and in combination withGarcinia cambogiaon visceral adiposity index (VAI) in obese patients.
  
  
  METHODS
  A total of 99 obese male patients were recruited with aged range between 37 and 46 years. They were randomized into three equal groups, first group treated with orlistat 120 mg/day, second group treated withG. cambogia166 mg/day, and third group treated with orlistat 120 mg/day plusG. cambogia166 mg/day. The duration of the treatments was three consecutive months. Body mass index (BMI), VAI, blood pressure, blood glucose, total lipid profile, atherogenic index, and cardiac risk ratio were recorded at baseline and after 3 months.
  
  
  RESULTS
  The treatment withG. cambogialeads to reduction in VAIP< 0.05, whereas orlistat has a beneficial effect on cardiometabolic profiles without a reduction in VAIP> 0.05. Combined therapy ofG. cambogiaplus orlistat showed the more significant effect in reduction of VAIP< 0.05, cardiometabolic profiles and anthropometric measuresP< 0.01 compared to pretreatment period.
  
  
  CONCLUSIONS
  Combination ofG. cambogiawith orlistat lead to more significant effect than orlistat alone in amelioration of cardiometabolic profile and VAI in obese patients.
authors.affiliation: Department of Clinical Pharmacology and Therapeutic, Medical Faculty College of Medicine, Al-Mustansiriya University, P.O. Box 14132, Baghdad, Iraq.
authors.forename: Hayder M
authors.initials: HM
authors.lastname: Al-Kuraishy
authors.affiliation: Department of Clinical Pharmacology and Therapeutic, Medical Faculty College of Medicine, Al-Mustansiriya University, P.O. Box 14132, Baghdad, Iraq.
authors.forename: Ali I
authors.initials: AI
authors.lastname: Al-Gareeb
keywords: Garcinia cambogia; obesity; orlistat