title: Novel Natural Product- and Privileged Scaffold-Based Tubulin Inhibitors Targeting the Colchicine Binding Site.
abstract: Tubulin inhibitors are effective anticancer agents, however, there are many limitations to the use of available tubulin inhibitors in the clinic, such as multidrug resistance, severe side-effects, and generally poor bioavailability. Thus, there is a constant need to search for novel tubulin inhibitors that can overcome these limitations. Natural product and privileged structures targeting tubulin have promoted the discovery and optimization of tubulin inhibitors. This review will focus on novel tubulin inhibitors derived from natural products and privileged structures targeting the colchicine binding site on tubulin.
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China. dongmengqi029@163.com.
authors.forename: Mengqi
authors.initials: M
authors.lastname: Dong
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China. liufanghuaxue@163.com.
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.affiliation: School of Environment, Guangzhou Key Laboratory of Environmental Exposure and Health and Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 510632, China. hyzhou001@gmail.com.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Zhou
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China. smzhai@sdu.edu.cn.
authors.forename: Shumei
authors.initials: S
authors.lastname: Zhai
authors.affiliation: School of Environment, Guangzhou Key Laboratory of Environmental Exposure and Health and Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 510632, China. drbingyan@yahoo.com.
authors.forename: Bing
authors.initials: B
authors.lastname: Yan
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D001665:Binding Sites / Q000187:drug effects; D001682:Biological Availability; D001688:Biological Products / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D003078:Colchicine / Q000031:analogs & derivatives / Q000737:chemistry*; D015394:Molecular Structure; D011485:Protein Binding; D013329:Structure-Activity Relationship; D050257:Tubulin Modulators / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D050257:Tubulin Modulators; D003078:Colchicine
keywords: antimitotic; microtubule dynamics; multidrug resistance; tubulin inhibitors