title: Evaluation of the Asymmetric Division of Drosophila Male Germline Stem Cells.
abstract: Asymmetric cell division (ACD) is utilized in many stem cell systems to produce two daughter cells with different cell fates. Despite the fundamental importance of ACD during development and tissue homeostasis, the nature of ACD is far from being fully understood. Step-by-step observation of events during ACD allows us to understand processes that lead to ACD. Here we describe examples of how we evaluate ACD in vivo using the Drosophila male germline stem cell system.
authors.affiliation: Department of Cell and Developmental Biology, Life Sciences Institute, Howard Hughes Medical Institute, University of Michigan Medical School, 210 Washtenaw Ave, Ann Arbor, MI, 48105, USA. minaba@umich.edu.|Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX, 75390-9148, USA. minaba@umich.edu.
authors.forename: Mayu
authors.initials: M
authors.lastname: Inaba
authors.affiliation: Department of Cell and Developmental Biology, Life Sciences Institute, Howard Hughes Medical Institute, University of Michigan Medical School, 210 Washtenaw Ave, Ann Arbor, MI, 48105, USA.
authors.forename: Yukiko M
authors.initials: YM
authors.lastname: Yamashita
mesh_terms: D000818:Animals; D060049:Asymmetric Cell Division; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D006706:Homeostasis; D008297:Male; D013094:Spermatozoa / Q000166:cytology*; D008941:Spindle Apparatus / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins
keywords: Asymmetric cell division (ACD); Centrosome orientation; Centrosome orientation checkpoint (COC); Drosophila male germline stem cells (GSCs); Spindle orientation