title: [The impact of the dosing, a 12-week physical training on the concentration of NT-proBNP and D-Dimer in patients with heart failure and impaired functional capacity in VII-X decade of life].
abstract: Chronic heart failure (CHF), despite the preventive measures taken is the most common problem of modern cardiology. The aging of the body predisposes to the development of PNS, because qualitative changes taking place in the heart of the patient in the elderly are similar to those occurring among patients with heart failure. A growing problem of eldery patients becomes a deterioration of physical fitness leading to the reduction of activity and sedentary lifestyle. There is no doubt that increasing physical activity in the elderly should aim not only to restore the patient to a previous level of functioning, but also improve their physical resources to a higher level of efficiency and to facilitate independent functioning in everyday life.
  
  
  OBJECTIVE
  The aim of the study was to analyze the assessment of 12-week controlled physical training on the concentration of NT-proBNP and D-Dimer in patients with heart failure and impaired functional capacity in VII-X decade of life.
  
  
  METHODS
  The study included a group of 72 patients, elderly men and women (within a mean age of 81,6 ± 6,4) with stable heart failure. The plasma concentration of B-type natriuretic peptide and D-Dimer was measured in each and every subject. The subjects were also asked to perform a Timed Up and Go Test (TUG) and the normal gait speed was analyzed over a 6 meter distance.
  
  
  RESULTS
  12-weeks cardiac rehabilitation process, improved the functional capacity of patients which is proved by reduction in duration of the TUG. Analysis of the results showed a correlation between the results of the test TUG and speed of gait. In the group of patients who underwent rehabilitation, a decrease in the concentration of plasma NT-proBNP and D-Dimer were observed.
  
  
  CONCLUSIONS
  The low-intensity physical training increases functional capacity which is shown to shorten the duration of the TUG test and affects the modulation of neuroendocrine and concentration of NT-proBNP in patients with CHF, regardless of gender.
authors.affiliation: Department of Internal Medicine and Cardiological Rehabilitation, Medical University of Lodz, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Andrzejczak-Karbowska
authors.affiliation: Department of Internal Medicine and Cardiological Rehabilitation, Medical University of Lodz, Poland.
authors.forename: Robert
authors.initials: R
authors.lastname: Irzmański
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015444:Exercise; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006333:Heart Failure / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010809:Physical Fitness; D011044:Poland
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D020097:Natriuretic Peptide, Brain
keywords: D-Dimer; NT-proBNP; aging; chronic heart failure (CHF); physical activity