title: Complete Resolution of Wegener's Granulomatosis Lung Granuloma After Aortic Root Replacement.
abstract: Wegner's granulomatosis (WG) is an autoimmune systemic vasculitis that results in necrotizing granulomas. We report a WG patient with a lung granuloma and aortic root dilatation, who underwent aortic root replacement on cardiopulmonary bypass (CPB). Intraoperatively, the patient suffered an aortic dissection, which was repaired immediately under deep hypothermic circulatory arrest (DHCA). Follow-up imaging showed complete granuloma resolution, despite absence of immunosuppressive therapy. Immune stimulation following CPB is well described; here, the opposite was observed and DHCA effects are discussed.
authors.affiliation: Royal Brompton Hospital NHS Foundation Trust, Department of Cardiothoracic Surgery, London, UK.
authors.forename: Sarah-Jayne
authors.initials: SJ
authors.lastname: Edmondson
authors.affiliation: Royal Brompton Hospital NHS Foundation Trust, Department of Cardiothoracic Surgery, London, UK.
authors.forename: Saina
authors.initials: S
authors.lastname: Attaran
authors.affiliation: Royal Brompton Hospital NHS Foundation Trust, Department of Cardiothoracic Surgery, London, UK.
authors.forename: Ulrich P
authors.initials: UP
authors.lastname: Rosendahl
keywords: Aortic root; Dissection; Inflammation; Wegener’s granulomatosis