title: The association between urinary liver-type fatty acid-binding protein and chronic kidney disease classification in HIV-infected Japanese patients.
abstract: BACKGROUND
  Renal dysfunction is recognized with increasing frequency among the noninfectious comorbidities associated with human immunodeficiency virus (HIV) infection. Urinary liver-type fatty acid-binding protein (L-FABP) has been shown to be a new biomarker to screen for not only tubulointerstitial damage but also kidney dysfunction.
  
  
  METHODS
  We performed a cross-sectional study to determine the association between the urinary L-FABP and chronic kidney disease (CKD) among 77 HIV-infected Japanese patients by backward-stepwise multivariable logistic regression.
  
  
  RESULTS
  The prevalence of individuals in the low risk was 80 %. Urinary L-FABP level was not associated with antiretroviral therapy and tenofovir disoproxil fumarate. On the other hand, urinary L-FABP level was independently associated with the CKD classification.
  
  
  CONCLUSIONS
  Urinary L-FABP may be used as an adjunct to diagnose the CKD stage.
authors.affiliation: Department of Pharmacy, The Hospital of Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan. ykhikasa@hyo-med.ac.jp.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Hikasa
authors.affiliation: Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Yasuda
authors.affiliation: Department of Pharmacy, The Hospital of Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Hideta
authors.affiliation: Department of Pharmacy, The Hospital of Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.
authors.forename: Mai
authors.initials: M
authors.lastname: Kawakami
authors.affiliation: Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Higasa
authors.affiliation: Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Sawada
authors.affiliation: Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
authors.forename: Tazuko
authors.initials: T
authors.lastname: Tokugawa
authors.affiliation: Department of Pharmacy, The Hospital of Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kimura
mesh_terms: D000328:Adult; D044466:Asian People; D003430:Cross-Sectional Studies; D050556:Fatty Acid-Binding Proteins / Q000652:urine*; D005260:Female; D005919:Glomerular Filtration Rate; D015658:HIV Infections / Q000150:complications / Q000652:urine*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011507:Proteinuria / Q000821:virology; D051436:Renal Insufficiency, Chronic / Q000652:urine* / Q000821:virology; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D050556:Fatty Acid-Binding Proteins
keywords: CKD; HIV; L-FABP