title: The associations between multisensory temporal processing and symptoms of schizophrenia.
abstract: Recent neurobiological accounts of schizophrenia have included an emphasis on changes in sensory processing. These sensory and perceptual deficits can have a cascading effect onto higher-level cognitive processes and clinical symptoms. One form of sensory dysfunction that has been consistently observed in schizophrenia is altered temporal processing. In this study, we investigated temporal processing within and across the auditory and visual modalities in individuals with schizophrenia (SCZ) and age-matched healthy controls. Individuals with SCZ showed auditory and visual temporal processing abnormalities, as well as multisensory temporal processing dysfunction that extended beyond that attributable to unisensory processing dysfunction. Most importantly, these multisensory temporal deficits were associated with the severity of hallucinations. This link between atypical multisensory temporal perception and clinical symptomatology suggests that clinical symptoms of schizophrenia may be at least partly a result of cascading effects from (multi)sensory disturbances. These results are discussed in terms of underlying neural bases and the possible implications for remediation.
authors.affiliation: The University of Western Ontario, Department of Psychology, London, ON, Canada; The University of Western Ontario, Brain and Mind Institute, London, ON, Canada. Electronic address: Rsteve28@uwo.ca.
authors.forename: Ryan A
authors.initials: RA
authors.lastname: Stevenson
authors.affiliation: Vanderbilt University, Department of Psychology, Nashville, TN, USA.
authors.forename: Sohee
authors.initials: S
authors.lastname: Park
authors.affiliation: Vanderbilt University, Department of Psychology, Nashville, TN, USA.
authors.forename: Channing
authors.initials: C
authors.lastname: Cochran
authors.affiliation: Vanderbilt University, Department of Psychology, Nashville, TN, USA.
authors.forename: Lindsey G
authors.initials: LG
authors.lastname: McIntosh
authors.affiliation: Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Noel
authors.affiliation: University of Toronto, Department of Psychology, Toronto, ON, Canada; Rotman Research Institute, Toronto, ON, Canada.
authors.forename: Morgan D
authors.initials: MD
authors.lastname: Barense
authors.affiliation: University of Toronto, Department of Psychology, Toronto, ON, Canada; Rotman Research Institute, Toronto, ON, Canada.
authors.forename: Susanne
authors.initials: S
authors.lastname: Ferber
authors.affiliation: Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA; Vanderbilt University Medical Center, Department of Hearing and Speech Sciences, Nashville, TN, USA; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt University, Department of Psychology, Nashville, TN, USA; Vanderbilt University Medical Center, Department of Psychiatry, Nashville, TN, USA.
authors.forename: Mark T
authors.initials: MT
authors.lastname: Wallace
mesh_terms: D000328:Adult; D001307:Auditory Perception / Q000502:physiology*; D005260:Female; D006212:Hallucinations / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010468:Perceptual Disorders / Q000209:etiology / Q000503:physiopathology*; D012559:Schizophrenia / Q000150:complications / Q000503:physiopathology*; D012720:Severity of Illness Index; D013998:Time Perception / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*
keywords: Audiovisual; Hallucinations; Multisensory integration; Schizophrenia; Speech perception; Temporal processing