title: Nuclear Lipids in the Nervous System: What they do in Health and Disease.
abstract: In the last 20 years it has been widely demonstrated that cell nucleus contains neutral and polar lipids localized in nuclear membranes, nucleoli, nuclear matrix and chromatin. Nuclear lipids may show specific organization forming nuclear lipid microdomains and have both structural and functional roles. Depending on their localization, nuclear lipids play different roles such as the regulation of nuclear membrane and nuclear matrix fluidity but they also can act as platforms for vitamin and hormone function, for active chromatin anchoring, and for the regulation of gene expression, DNA duplication and transcription. Crosstalk among different kinds of lipid signalling pathways influence the physiopathology of numerous cell types. In neural cells the nuclear lipids are involved in cell proliferation, differentiation, inflammation, migration and apoptosis. Abnormal metabolism of nuclear lipids might be closely associated with tumorigenesis and neurodegenerative diseases such as Alzheimer disease and Parkinson disease among others.
authors.affiliation: Department of Biology, University of Pisa, via S. Zeno 31, 56127, Pisa, Italy. mercedes.garcia@unipi.it.|Interdepartmental Research Center "Nutraceuticals and Food for Health", University of Pisa, Pisa, Italy. mercedes.garcia@unipi.it.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Garcia-Gil
authors.affiliation: Laboratory of Nuclear Lipid BioPathology, CRABiON, Perugia, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Albi
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism*; D049109:Cell Proliferation / Q000502:physiology; D053938:DNA Fragmentation; D006304:Health Status; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology*; D008055:Lipids / Q000235:genetics; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D009420:Nervous System / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D008055:Lipids
keywords: Cholesterol; Lipid; Neurodegenerative diseases; Nuclear lipid microdomains; Nucleus; Polyphosphoinositides; Sphingolipids