title: Tertiary Lymphoid Structures in Cancers: Prognostic Value, Regulation, and Manipulation for Therapeutic Intervention.
abstract: Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates that reflect lymphoid neogenesis occurring in tissues at sites of inflammation. They are detected in tumors where they orchestrate local and systemic anti-tumor responses. A correlation has been found between high densities of TLS and prolonged patient's survival in more than 10 different types of cancer. TLS can be regulated by the same set of chemokines and cytokines that orchestrate lymphoid organogenesis and by regulatory T cells. Thus, TLS offer a series of putative new targets that could be used to develop therapies aiming to increase the anti-tumor immune response.
authors.affiliation: INSERM, UMR_S 1138, Team "Cancer, Immune Control and Escape", Cordeliers Research Center, Paris, France; UMR_S 1138, Centre de Recherche des Cordeliers, University Paris Descartes, Paris, France; UMR_S 1138, Centre de Recherche des Cordeliers, Sorbonne University, UPMC University Paris 06, Paris, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Sautès-Fridman
authors.affiliation: INSERM, UMR_S 1138, Team "Cancer, Immune Control and Escape", Cordeliers Research Center, Paris, France; UMR_S 1138, Centre de Recherche des Cordeliers, University Paris Descartes, Paris, France; UMR_S 1138, Centre de Recherche des Cordeliers, Sorbonne University, UPMC University Paris 06, Paris, France.
authors.forename: Myriam
authors.initials: M
authors.lastname: Lawand
authors.affiliation: INSERM, UMR_S 1138, Team "Cancer, Immune Control and Escape", Cordeliers Research Center, Paris, France; UMR_S 1138, Centre de Recherche des Cordeliers, University Paris Descartes, Paris, France; UMR_S 1138, Centre de Recherche des Cordeliers, Sorbonne University, UPMC University Paris 06, Paris, France.
authors.forename: Nicolas A
authors.initials: NA
authors.lastname: Giraldo
authors.affiliation: INSERM, UMR_S 1138, Team "Cancer, Immune Control and Escape", Cordeliers Research Center, Paris, France; UMR_S 1138, Centre de Recherche des Cordeliers, University Paris Descartes, Paris, France; UMR_S 1138, Centre de Recherche des Cordeliers, Sorbonne University, UPMC University Paris 06, Paris, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Kaplon
authors.affiliation: INSERM, UMR_S 1138, Team "Cancer, Immune Control and Escape", Cordeliers Research Center, Paris, France; UMR_S 1138, Centre de Recherche des Cordeliers, University Paris Descartes, Paris, France; UMR_S 1138, Centre de Recherche des Cordeliers, Sorbonne University, UPMC University Paris 06, Paris, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Germain
authors.affiliation: INSERM, UMR_S 1138, Team "Cancer, Immune Control and Escape", Cordeliers Research Center, Paris, France; UMR_S 1138, Centre de Recherche des Cordeliers, University Paris Descartes, Paris, France; UMR_S 1138, Centre de Recherche des Cordeliers, Sorbonne University, UPMC University Paris 06, Paris, France.
authors.forename: Wolf Herman
authors.initials: WH
authors.lastname: Fridman
authors.affiliation: INSERM, UMR_S 1138, Team "Cancer, Immune Control and Escape", Cordeliers Research Center, Paris, France; UMR_S 1138, Centre de Recherche des Cordeliers, University Paris Descartes, Paris, France; UMR_S 1138, Centre de Recherche des Cordeliers, Sorbonne University, UPMC University Paris 06, Paris, France.
authors.forename: Marie-Caroline
authors.initials: MC
authors.lastname: Dieu-Nosjean
keywords: adaptive immune response; cancer; chemokine; tertiary lymphoid structure; tumor microenvironment