title: Role of phosphatidylinositol-4,5-bisphosphate 3-kinase signaling in vesicular trafficking.
abstract: Phosphatidylinositol-4,5-bisphosphate 3-kinases (PI3Ks) are regulatory enzymes involved in the generation of lipid species that modulate cellular signaling pathways through downstream effectors to influence a variety of cellular functions. Years of intensive study of PI3Ks have produced a significant body of literature in many areas, including that PI3K can mediate intracellular vesicular trafficking and through these actions contribute to a number of important physiological functions. This review focuses on the crucial roles that PI3K and AKT, a major downstream partner of PI3K, play in the regulation of vesicle trafficking during various forms of vesicular endocytosis and exocytosis.
authors.affiliation: Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 473 W. 12th Ave., Columbus, OH 43210-1252, United States.
authors.forename: Sayak
authors.initials: S
authors.lastname: Bhattacharya
authors.affiliation: Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 473 W. 12th Ave., Columbus, OH 43210-1252, United States.
authors.forename: Kevin E
authors.initials: KE
authors.lastname: McElhanon
authors.affiliation: Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 473 W. 12th Ave., Columbus, OH 43210-1252, United States.
authors.forename: Liubov V
authors.initials: LV
authors.lastname: Gushchina
authors.affiliation: Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 473 W. 12th Ave., Columbus, OH 43210-1252, United States. Electronic address: noah.weisleder@osumc.edu.
authors.forename: Noah
authors.initials: N
authors.lastname: Weisleder
mesh_terms: D000818:Animals; D004705:Endocytosis; D005089:Exocytosis; D006801:Humans; D019869:Phosphatidylinositol 3-Kinases / Q000032:analysis / Q000378:metabolism*; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000032:analysis / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000032:analysis / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D019869:Phosphatidylinositol 3-Kinases; D017853:Phosphotransferases (Alcohol Group Acceptor); C068961:phosphatidylinositol 4,5-biphosphate kinase; D051057:Proto-Oncogene Proteins c-akt
keywords: AKT; Caveolae; Clathrin; Endocytosis; Exocytosis; Membrane trafficking; PI3K; Phosphatidylinositol-4,5-bisphosphate 3-kinase; Protein kinase B