title: [Vitamin D and autoimmune thyroid diseases].
abstract: From the recent literature data it may be concluded that vitamin D deficiency is associated with increased risk of thyroid autoimmunity development and thus should be considered as an additional important risk factor for both chronic autoimmune thyroiditis (postpartum thyroiditis including) and Graves´ disease. A higher risk of Graves´ disease development is also associated with several polymorphisms in the gene encoding for vitamin D binding protein and for the specific receptor of active form of vitamin D - 1,25-(OH)2D3 in the respective target cells. Whether careful supplementation with vitamin D aimed to normalize low 25(OH)D levels brings preventive or therapeutic effect is subject to further research.Key words: autoimmune thyroiditis - D vitamin deficiency - D vitamin supplementation - Graves´disease.
authors.forename: Karel
authors.initials: K
authors.lastname: Vondra
mesh_terms: D019587:Dietary Supplements; D006111:Graves Disease / Q000453:epidemiology* / Q000378:metabolism; D006801:Humans; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics; D013967:Thyroiditis, Autoimmune / Q000453:epidemiology* / Q000378:metabolism; D014807:Vitamin D / Q000031:analogs & derivatives / Q000378:metabolism / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000453:epidemiology* / Q000235:genetics / Q000378:metabolism; D014809:Vitamin D-Binding Protein / Q000235:genetics; D014815:Vitamins / Q000627:therapeutic use
chemical_list: D018167:Receptors, Calcitriol; D014809:Vitamin D-Binding Protein; D014815:Vitamins; D014807:Vitamin D; C104450:25-hydroxyvitamin D