title: Clinical features and postoperative seizure outcome in patients with drug-resistant gelastic seizures without hypothalamic hamartoma.
abstract: The objective of this study was to describe the clinical characteristics and surgical outcome in patients with gelastic seizures without hypothalamic hamartoma.
  
  
  
  We retrospectively reviewed all the video-EEG reports over a 5-year period (2007-2011) for the occurrence of the terms "laugh" or "giggle" in the text body. All the patients with at least one documented gelastic seizure at the epilepsy monitoring unit were studied. In patients who underwent epilepsy surgery, seizure outcomes were analyzed.
  
  
  
  Sixteen patients (10 females and 6 males) with a mean age of 46.3years were studied. Seven patients had invasive intracranial EEG recordings. Seizure onset zone was in a temporal lobe in four patients and the frontal lobe in one patient. Two patients did not have gelastic seizures during their intracranial EEG monitoring. Nine patients underwent resective epilepsy surgery for their seizures. Six patients (67%) were seizure-free after surgery.
  
  
  
  In adult patients, gelastic seizures can be seen in patients with focal epilepsy without hypothalamic hamartoma. Nonhypothalamic hamartoma gelastic seizures originating from the temporal lobe can be amenable to surgery.
authors.affiliation: Temple University Comprehensive Epilepsy Center, Department of Neurology, Temple University Hospital, Philadelphia, PA, USA. Electronic address: Camilo.Gutierrez@tuhs.temple.edu.
authors.forename: Camilo
authors.initials: C
authors.lastname: Gutierrez
authors.affiliation: Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, PA, USA.
authors.forename: Ali A
authors.initials: AA
authors.lastname: Asadi-Pooya
authors.affiliation: Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, PA, USA.
authors.forename: Christopher T
authors.initials: CT
authors.lastname: Skidmore
authors.affiliation: Neurological Institute of New York, Columbia University Medical Center, New York, NY, USA.
authors.forename: Steven D
authors.initials: SD
authors.lastname: Tobochnik
authors.affiliation: Drexel Neurosciences Institute, Drexel University, Philadelphia, PA, USA.
authors.forename: Carla
authors.initials: C
authors.lastname: LoPinto-Khoury
authors.affiliation: Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, PA, USA.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Sperling
mesh_terms: D000328:Adult; D000069279:Drug Resistant Epilepsy / Q000503:physiopathology / Q000601:surgery*; D000069280:Electrocorticography; D004828:Epilepsies, Partial / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007845:Laughter / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D012189:Retrospective Studies
keywords: Clinical; Gelastic seizures; Outcome; Surgery