title: Epigenetic determinants of metastasis.
abstract: Genetic analyses of cancer progression in patient samples and model systems have thus far failed to identify specific mutational drivers of metastasis. Yet, at least in experimental systems, metastatic cancer clones display stable traits that can facilitate progression through the many steps of metastasis. How cancer cells establish and maintain the transcriptional programmes required for metastasis remains mostly unknown. Emerging evidence suggests that metastatic traits may arise from epigenetically altered transcriptional output of the oncogenic signals that drive tumour initiation and early progression. Molecular dissection of such mechanisms remains a central challenge for a comprehensive understanding of the origins of metastasis.
authors.affiliation: MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge, CB2 0XZ, United Kingdom.
authors.forename: Saroor A
authors.initials: SA
authors.lastname: Patel
authors.affiliation: MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge, CB2 0XZ, United Kingdom. Electronic address: sv358@mrc-cu.cam.ac.uk.
authors.forename: Sakari
authors.initials: S
authors.lastname: Vanharanta
keywords: Cancer; Epigenetic; Metastasis