title: Anti-obese effects of two Lactobacilli and two Bifidobacteria on ICR mice fed on a high fat diet.
abstract: Previous researchers have documented that probiotic bacteria can have anti-obesity effects on mice fed a high fat diet (HFD) and improve metabolic syndrome. The beneficial effects of the probiotic bacteria are suggested to be strain dependent. In this study, two candidate lactobacteria strains, Lactobacillus casei IBS041, Lactobacillus acidophilus AD031 and two bifidobacteria strains, Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI, were individually administered to HFD-fed mice for 8 weeks. B. longum BORI significantly suppressed mouse weight gain without affecting food intake. L. acidophilus and B. bifidum BGN4 significantly decreased triglyceride levels in mouse liver while B. longum BORI significantly lowered total cholesterol levels in liver. L. acidophilus and B. bifidum BGN4 significantly inhibited serum activities of aspartate transaminase and alanine transaminase. Diet supplementation with L. acidophilus, B. bifidum BGN4 and B. longum BORI efficiently improved hepatocyte hydropic degeneration and hepatic steatosis. Of the four probiotic candidates, the bifidobacteria B. longum BORI and B. bifidum BGN4, developed in our laboratory, and L. acidophilus AD031showed excellent anti-obesity effects and suppressed lipid deposition in liver.
authors.affiliation: Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University, Seoul, 151-742, Republic of Korea.
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University, Seoul, 151-742, Republic of Korea.
authors.forename: Hui
authors.initials: H
authors.lastname: Jin
authors.affiliation: Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University, Seoul, 151-742, Republic of Korea.
authors.forename: So Young
authors.initials: SY
authors.lastname: Oh
authors.affiliation: Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University, Seoul, 151-742, Republic of Korea; Research Institute, Bifido Co., Ltd., Hongchun, 250-804, Republic of Korea. Electronic address: geji@snu.ac.kr.
authors.forename: Geun Eog
authors.initials: GE
authors.lastname: Ji
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D001219:Aspartate Aminotransferases / Q000097:blood; D001644:Bifidobacterium; D001835:Body Weight / Q000187:drug effects; D059305:Diet, High-Fat / Q000009:adverse effects; D019587:Dietary Supplements; D004435:Eating / Q000187:drug effects; D007778:Lactobacillus; D007779:Lactobacillus acidophilus; D007780:Lacticaseibacillus casei; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008813:Mice, Inbred ICR; D015434:Panniculitis / Q000178:diet therapy / Q000473:pathology; D019936:Probiotics / Q000494:pharmacology*
chemical_list: D019440:Anti-Obesity Agents; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
keywords: Anti-obesity; Bifidobacteria; Fatty liver; Inflammation; Lactobacteria