title: Vestibular Perceptual Thresholds Increase above the Age of 40.
abstract: We measured vestibular perceptual thresholds in 105 healthy humans (54F/51M) ranging from 18 to 80 years of age. Direction-recognition thresholds were measured using standard methods. The motion consisted of single cycles of sinusoidal acceleration at 0.2 Hz for roll tilt and 1.0 Hz for yaw rotation about an earth-vertical axis, inter-aural earth-horizontal translation (y-translation), inferior-superior earth-vertical translation (z-translation), and roll tilt. A large subset of this population (99 of 105) also performed a modified Romberg test of standing balance. Despite the relatively large population (54F/51M), we found no difference between thresholds of male and female subjects. After pooling across sex, we found that thresholds increased above the age of 40 for all five motion directions investigated. The data were best modeled by a two-segment age model that yielded a constant baseline below an age cutoff of about 40 and a threshold increase above the age cutoff. For all subjects who passed all conditions of the balance test, the baseline thresholds were 0.97°/s for yaw rotation, 0.66°/s for 1-Hz roll tilt, 0.35°/s for 0.2-Hz roll tilt, 0.58 cm/s fory-translation, and 1.24 cm/s forz-translation. As a percentage of the baseline, the fitted slopes (indicating the threshold increase each decade above the age cutoff) were 83% forz-translation, 56% for 1-Hz roll tilt, 46% fory-translation, 32% for 0.2-Hz roll tilt, and 15% for yaw rotation. Even taking age and other factors into consideration, we found a significant correlation of balance test failures with increasing roll-tilt thresholds.
authors.affiliation: Harvard Medical School, Boston, MA, USA; Jenks Vestibular Physiology Laboratory, MEEI, Boston, MA, USA.
authors.forename: María Carolina
authors.initials: MC
authors.lastname: Bermúdez Rey
authors.affiliation: Harvard Medical School, Boston, MA, USA; Jenks Vestibular Physiology Laboratory, MEEI, Boston, MA, USA; University of Colorado at Boulder, Boulder, CO, USA.
authors.forename: Torin K
authors.initials: TK
authors.lastname: Clark
authors.affiliation: Harvard Medical School, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Jenks Vestibular Physiology Laboratory, MEEI , Boston, MA , USA.
authors.forename: Tania
authors.initials: T
authors.lastname: Leeder
authors.affiliation: Harvard Medical School, Boston, MA, USA; Jenks Vestibular Physiology Laboratory, MEEI, Boston, MA, USA.
authors.forename: Yong
authors.initials: Y
authors.lastname: Bian
authors.affiliation: Harvard Medical School, Boston, MA, USA; Jenks Vestibular Physiology Laboratory, MEEI, Boston, MA, USA.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Merfeld
keywords: aging; perception; thresholds; vestibular