title: Premenopausal abnormal uterine bleeding and risk of endometrial cancer.
abstract: Endometrial biopsies are undertaken in premenopausal women with abnormal uterine bleeding but the risk of endometrial cancer or atypical hyperplasia is unclear.
  
  
  
  To conduct a systematic literature review to establish the risk of endometrial cancer and atypical hyperplasia in premenopausal women with abnormal uterine bleeding.
  
  
  
  Search of PubMed, Embase and the Cochrane Library from database inception to August 2015.
  
  
  
  Studies reporting rates of endometrial cancer and/or atypical hyperplasia in women with premenopausal abnormal uterine bleeding.
  
  
  
  Data were independently extracted by two reviewers and cross-checked. For each outcome, the risk and a 95% CI were estimated using logistic regression with robust standard errors to account for clustering by study.
  
  
  
  Sixty-five articles contributed to the analysis. Risk of endometrial cancer was 0.33% (95% CI 0.23-0.48%, n = 29 059; 97 cases) and risk of endometrial cancer or atypical hyperplasia was 1.31% (95% CI 0.96-1.80, n = 15 772; 207 cases). Risk of endometrial cancer was lower in women with heavy menstrual bleeding (HMB) (0.11%, 95% CI 0.04-0.32%, n = 8352; 9 cases) compared with inter-menstrual bleeding (IMB) (0.52%, 95% CI 0.23-1.16%, n = 3109; 14 cases). Of five studies reporting the rate of atypical hyperplasia in women with HMB, none identified any cases.
  
  
  
  The risk of endometrial cancer or atypical hyperplasia in premenopausal women with abnormal uterine bleeding is low. Premenopausal women with abnormal uterine bleeding should first undergo conventional medical management. Where this fails, the presence of IMB and older age may be indicators for further investigation. Further research into the risks associated with age and the cumulative risk of co-morbidities is needed.
  
  
  
  Contrary to practice, premenopausal women with heavy periods or inter-menstrual bleeding rarely require biopsy.
authors.affiliation: Public Health Directorate, Cambridgeshire County Council, Cambridge, UK.
authors.forename: M E
authors.initials: ME
authors.lastname: Pennant
authors.affiliation: Cambridge University Hospitals NHS Foundation trust, Cambridge, UK.
authors.forename: R
authors.initials: R
authors.lastname: Mehta
authors.affiliation: Cambridge University Hospitals NHS Foundation trust, Cambridge, UK.
authors.forename: P
authors.initials: P
authors.lastname: Moody
authors.affiliation: Cambridge University Hospitals NHS Foundation trust, Cambridge, UK.
authors.forename: G
authors.initials: G
authors.lastname: Hackett
authors.affiliation: Cambridge University Hospitals NHS Foundation trust, Cambridge, UK.|Department of Obstetrics & Gynaecology, University of Cambridge, Cambridge, UK.
authors.forename: A
authors.initials: A
authors.lastname: Prentice
authors.affiliation: Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK.
authors.forename: S J
authors.initials: SJ
authors.lastname: Sharp
authors.affiliation: Public Health Directorate, Cambridgeshire County Council, Cambridge, UK.|Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK.
authors.forename: R
authors.initials: R
authors.lastname: Lakshman
mesh_terms: D004714:Endometrial Hyperplasia / Q000150:complications / Q000453:epidemiology*; D016889:Endometrial Neoplasms / Q000150:complications / Q000453:epidemiology*; D004717:Endometrium / Q000473:pathology; D005260:Female; D006801:Humans; D017697:Premenopause; D015995:Prevalence; D012306:Risk; D018570:Risk Assessment / Q000379:methods; D014592:Uterine Hemorrhage / Q000209:etiology*
keywords: Biopsy; endometrial neoplasms; premenopause; risk; systematic review