title: The Basic Science of Bone Marrow Aspirate Concentrate in Chondral Injuries.
abstract: There has been great interest in bone marrow aspirate concentrate (BMAC) as a cost effective method in delivering mesenchymal stem cells (MSCs) to aid in the repair and regeneration of cartilage defects. Alongside MSCs, BMAC contains a range of growth factors and cytokines to support cell growth following injury. However, there is paucity of information relating to the basic science underlying BMAC and its exact biological role in supporting the growth and regeneration of chondrocytes. The focus of this review is the basic science underlying BMAC in relation to chondral damage and regeneration.
authors.affiliation: Royal Orthopedic Hospital , The Woodlands, Birmingham, West Midlands, UK.
authors.forename: James
authors.initials: J
authors.lastname: Holton
authors.affiliation: Royal Orthopedic Hospital, The Woodlands, Birmingham, West Midlands, UK; Department of Orthopedics, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Imam
authors.affiliation: Royal Orthopedic Hospital , The Woodlands, Birmingham, West Midlands, UK.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Ward
authors.affiliation: Royal Orthopedic Hospital , The Woodlands, Birmingham, West Midlands, UK.
authors.forename: Martyn
authors.initials: M
authors.lastname: Snow
keywords: Bone; aspirate; cartilage; concentrate; marrow