title: Characterization of Human Pregnancy Specific Glycoprotein (PSG) Gene Copy Number Variations in Pre-eclampsia Patients.
abstract: Pre-eclampsia is a pregnancy-specific hypertensive disorder that affects 2-8 % of pregnancies. This disorder can lead to seizure, multi-organ failure and maternal death. The best approach to prevent pre-eclampsia-associated adverse outcomes is to be able to prevent pre-eclampsia as early as possible. Unfortunately, current diagnostic methods are ineffective at predicting the risk of pre-eclampsia during early pregnancy. In humans, low levels of a group of placenta-derived Pregnancy Specific Glycoproteins (PSGs) have been associated with intrauterine growth retardation and pre-eclampsia and there is a significant enrichment of cases with deletions in the PSG gene locus in pre-eclampsia patients. Based on these observations, we hypothesize that genomic variations at human PSG locus of maternal and/or fetal genomes may confer increased risks of pre-eclampsia. To test this hypothesis, we have recruited 90 normal control and 30 pre-eclamptic women for the analysis of fetal PSG copy number variations (CNVs).The identification of novel PSG CNV-disease relationships will provide not only a better understanding of the pathology of pre-eclampsia but also a novel opportunity to identify patients with a high risk of developing early-onset pre-eclampsia, which has a five- to tenfold higher risk of life-threatening maternal complications and fetal demise as compared to late-onset pre-eclampsia patients.
authors.affiliation: Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University, Tao-Yuan, Taiwan ROC. amego@cgmh.org.tw.
authors.forename: Chia Lin
authors.initials: CL
authors.lastname: Chang
authors.affiliation: Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University, Tao-Yuan, Taiwan ROC.
authors.forename: Chia Yu
authors.initials: CY
authors.lastname: Chang
authors.affiliation: Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University, Tao-Yuan, Taiwan ROC.
authors.forename: Da Xian
authors.initials: DX
authors.lastname: Lee
authors.affiliation: Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University, Tao-Yuan, Taiwan ROC.
authors.forename: Po Jen
authors.initials: PJ
authors.lastname: Cheng
mesh_terms: D002465:Cell Movement / Q000235:genetics; D002478:Cells, Cultured; D002824:Chorionic Villi / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D004247:DNA / Q000097:blood / Q000235:genetics / Q000378:metabolism; D056915:DNA Copy Number Variations; D005260:Female; D006801:Humans; D010920:Placenta / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D011225:Pre-Eclampsia / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000235:genetics* / Q000378:metabolism; D011261:Pregnancy Trimester, First; D012307:Risk Factors; D017422:Sequence Analysis, DNA / Q000379:methods; D014327:Trophoblasts / Q000378:metabolism
chemical_list: D016207:Cytokines; D011257:Pregnancy Proteins; D004247:DNA
keywords: Copy number variations; Pre-eclampsia; Pregnancy specific glycoproteins