title: [Epidemiology, risk factors and in vitro susceptibility in candidaemia due to non-Candida albicans species].
abstract: BACKGROUND
  Invasive fungal infection (IFI) has increased in recent years due to there being a greater number of risk factors. IFI caused by Candida is the most frequent, and although Candida albicans is the most isolated species, there is currently a decrease of C. albicans and an increase of other species of the genus.
  
  
  OBJECTIVE
  To analyse the epidemiology, risk factors, and antifungal susceptibility of blood culture isolates of non-C.albicans Candida species in our hospital in the last 12years.
  
  
  METHODS
  A retrospective study was conducted on 107 patients with candidaemia admitted to our hospital. Candida isolates susceptibility to fluconazole, itraconazole, voriconazole, amphotericinB, 5-fluorocytosine, caspofungin, micafungin, and anidulafungin was determined by means of a microdilution technique (Sensititre Yeast One; Izasa, Spain).
  
  
  RESULTS
  From a total of 109 strains, 59 belonged to non-C. albicans Candida species: 25 Candida parapsilosis complex, 14 Candida glabrata complex, 13 Candida tropicalis, 4 Candida krusei, 1 Candida lipolytica, 1 Candida membranaefaciens, and 1 Candida pulcherrima. The most common risk factor in adults and children was catheter use. It was observed that 8.5% of those non-C.albicans strains were resistant to fluconazole.
  
  
  CONCLUSIONS
  The results of this work confirm that it is necessary to know the epidemiology of non-C.albicans Candida species, the in vitro susceptibility of the species involved, and the main risk factors, especially in patients with predisposing conditions.
authors.affiliation: Unidad de Gestión Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, España. Electronic address: elenita_m_m@hotmail.com.
authors.forename: Elena M
authors.initials: EM
authors.lastname: Marín Martínez
authors.affiliation: Unidad de Gestión Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, España.
authors.forename: Ana Isabel
authors.initials: AI
authors.lastname: Aller García
authors.affiliation: Unidad de Gestión Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, España.
authors.forename: Estrella
authors.initials: E
authors.lastname: Martín-Mazuelos
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002175:Candida / Q000187:drug effects* / Q000302:isolation & purification; D058387:Candidemia / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009172:Mycology / Q000379:methods; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000935:Antifungal Agents
keywords: Candida; Candidaemia; Candidemia; Epidemiology; Epidemiología; Factores de riesgo; Risk factors; Sensibilidad; Susceptibility