title: Hepatitis C virus-induced glucose metabolic disorder.
abstract: Hepatitis C virus (HCV) infection often causes intrahepatic diseases, such as chronic hepatitis, liver chirrohsis, and hepatocellular carcinoma (HCC). Moreover, HCV infection exhibits various extrahepatic manifestations, such as thyroiditis, glucose and lipid metabolic disorder, and iron metabolic disorder. HCV infection is often associated with type 2 diabetes, involving hepatic fibrosis and poor prognosis. Type 2 diabetes increases the risk of HCC. We have been investigating molecular mechanisms of HCV-induced glucose metabolic disorder and we reported that HCV infection promotes hepatic gluconeogenesis through forkhead box O1 (FoxO1)-dependent pathway and that HCV infection suppresses the cell surface expression of glucose transporter 2 (GLUT2), resulting in suppression of glucose uptake. We have found that HCV NS5A protein plays important roles in these two independent pathways. Here we discuss the roles of HCV NS5A in HCV-induced glucose metabolic disorder.
authors.affiliation: Division of Infectious Disease Control, Center for Infectious Diseases, Kobe University Graduate School of Medicine.
authors.forename: Ikuo
authors.initials: I
authors.lastname: Shoji
authors.forename: Lin
authors.initials: L
authors.lastname: Deng
authors.forename: Chieko
authors.initials: C
authors.lastname: Matsui
authors.forename: Hak
authors.initials: H
authors.lastname: Hotta
mesh_terms: D000071161:Forkhead Box Protein O1 / Q000502:physiology; D005943:Gluconeogenesis / Q000235:genetics; D005947:Glucose / Q000378:metabolism; D044882:Glucose Metabolism Disorders / Q000209:etiology* / Q000378:metabolism; D051273:Glucose Transporter Type 2 / Q000378:metabolism; D016174:Hepacivirus / Q000235:genetics; D006526:Hepatitis C / Q000150:complications* / Q000378:metabolism / Q000821:virology*; D006801:Humans; D008099:Liver / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D017361:Viral Nonstructural Proteins / Q000502:physiology*; D012324:RNA-Dependent RNA Polymerase
chemical_list: D000071161:Forkhead Box Protein O1; D005947:Glucose; D051273:Glucose Transporter Type 2; D017361:Viral Nonstructural Proteins; C085126:FOXO1 protein, human; C495680:SLC2A2 protein, human; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase