title: Encapsulation of the HDACi Ex527 into Liposomes and Polymer-Based Particles.
abstract: Incorporation of drugs into particles can improve their therapeutic effectiveness. Solubility, half-life time, targeting, and the release of the drug can be modified by the encapsulation into a particle. Histone deacetylase inhibitors have a great potential to be used as therapeutics for many different diseases. In this chapter, we describe the inclusion of the low molar mass HDACi Ex527 into polymer-based particles and liposomes.
authors.affiliation: Institute for Molecular Medicine, Cancer and Inflammation Research, University of Southern Denmark, J.B. Winsløws Vej 25, Odense C, 5000, Denmark.
authors.forename: Dorle
authors.initials: D
authors.lastname: Hennig
authors.affiliation: Pharmaceutical Chemistry I, Institute of Pharmacy, Rheinische Friedrich Wilhelms University, Bonn, Brühler Str. 7, Bonn, 53119, Germany. dimhof@uni-bonn.de.
authors.forename: Diana
authors.initials: D
authors.lastname: Imhof
mesh_terms: D000107:Acetylation; D002227:Carbazoles / Q000737:chemistry / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D003911:Dextrans / Q000737:chemistry; D004339:Drug Compounding / Q000379:methods*; D005434:Flow Cytometry; D005456:Fluorescent Dyes / Q000737:chemistry; D057809:HEK293 Cells; D006207:Half-Life; D056572:Histone Deacetylase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry / Q000378:metabolism*; D010713:Phosphatidylcholines / Q000737:chemistry; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D012235:Rhodamines / Q000737:chemistry; D012995:Solubility
chemical_list: C550547:6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide; D002227:Carbazoles; D003911:Dextrans; D005456:Fluorescent Dyes; D056572:Histone Deacetylase Inhibitors; D008081:Liposomes; D010713:Phosphatidylcholines; D012235:Rhodamines; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C029773:rhodamine B
keywords: Acetalated dextran; Cellular uptake; Ex527; Histone deacetylase inhibitor; Liposomes; PLGA