title: Pharmaceutical and Clinical Aspects of Lipid Injectable Emulsions.
abstract: The first clinically successful lipid injectable emulsion was marketed in 1961, consisting of soybean oil triglycerides in sterile water for injection. Since that time, numerous products have entered the market, with the main difference being changes in the oil composition with triglycerides of plant and marine oil origin. With this change, the fatty acid profiles are unique, coming from medium- and long-chain triglycerides. The fatty acids can be saturated or unsaturated, having different pharmaceutical and metabolic activities that affect the safety and efficacy of these unique pharmaceutical dosage forms.
authors.affiliation: 1 Stable Solutions LLC, Easton Industrial Park, Easton, Massachusetts.|2 UMASS Medical School, Worcester, Massachusetts, USA.
authors.forename: David F
authors.initials: DF
authors.lastname: Driscoll
mesh_terms: D055598:Chemical Phenomena; D004305:Dose-Response Relationship, Drug; D005217:Fat Emulsions, Intravenous / Q000737:chemistry* / Q000494:pharmacology*; D005227:Fatty Acids / Q000008:administration & dosage / Q000032:analysis; D005395:Fish Oils / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology; D013024:Soybean Oil / Q000737:chemistry / Q000494:pharmacology; D014280:Triglycerides / Q000737:chemistry / Q000494:pharmacology
chemical_list: D005217:Fat Emulsions, Intravenous; D005227:Fatty Acids; D005395:Fish Oils; D010938:Plant Oils; D014280:Triglycerides; D013024:Soybean Oil
keywords: administration; lipids; nutrition; nutrition support practice; parenteral nutrition