title: Serum miR-221 serves as a biomarker for Parkinson's disease.
abstract: Parkinson's disease (PD) is the common age-related neurodegenerative disorder. Sensitive, noninvasive biomarkers that facilitate PD diagnosis and stage assignment are currently unavailable. This study aims to investigate the potential of 16 previous reported PD-associated miRNAs as novel biomarkers for PD. The expression of 16 serum miRNAs was measured by quantitative reverse transcriptase polymerase chain reaction in 138 PD patients and 112 control populations. Analyses were undertaken to assess the specificity and sensitivity of miRNAs to predict PD. In addition, the relationship between deregulated miRNAs and Part III of the United Parkinson's Disease Rating Scale (UPDRS-III) and Part V of the UPDRS (UPDRS-V; the modified Hoehn and Yahr staging of PD) in PD patients was also assessed. It was found that the serums miR-29c, miR-146a, miR-214, and miR-221 were significantly decreased in PD patients compared with healthy control populations. In addition, serum miR-221 was positively correlated with UPDRS-III (r = .4702) and UPDRS-V (r = .4788) score in PD patients. Furthermore, the receiver operating characteristic result of serum miR-221 for prediction of PD was 0.787. Our preliminary findings indicate that downregulated serum miR-221 might be a potential biomarker for PD evaluation.
authors.affiliation: Department of Neurology, Qilu Hospital of Shandong University, Jinan, Shandong, People's Republic of China.|Department of Neurology, Binzhou Medical University Hospital, Binzhou, Shandong, People's Republic of China.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Ma
authors.affiliation: Department of Pediatrics, Binzhou Medical University Hospital, Binzhou, Shandong, People's Republic of China.|Department of Pediatrics Nephrology and Rheumatism and Immunology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, People's Republic of China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Affiliated Hospital of Qingdao University, Qingdao, Shandong, People's Republic of China.
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.affiliation: Interdisciplinary Division of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, SAR, People's Republic of China.
authors.forename: Fan
authors.initials: F
authors.lastname: Xu
authors.affiliation: Department of Neurology, Qilu Hospital of Shandong University, Jinan, Shandong, People's Republic of China.|Department of Neurology, Binzhou Medical University Hospital, Binzhou, Shandong, People's Republic of China.
authors.forename: Meiling
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Neurology, Qilu Hospital of Shandong University, Jinan, Shandong, People's Republic of China. yimingliu223@126.com.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics*; D010300:Parkinson Disease / Q000097:blood* / Q000235:genetics*; D012372:ROC Curve
chemical_list: D015415:Biomarkers; D035683:MicroRNAs; C525709:MIR221, human
keywords: Parkinson's disease; biomarker; miR-221; serum miRNA