title: Brain response pattern identification of fMRI data using a particle swarm optimization-based approach.
abstract: Many neuroscience studies have been devoted to understand brain neural responses correlating to cognition using functional magnetic resonance imaging (fMRI). In contrast to univariate analysis to identify response patterns, it is shown that multi-voxel pattern analysis (MVPA) of fMRI data becomes a relatively effective approach using machine learning techniques in the recent literature. MVPA can be considered as a multi-objective pattern classification problem with the aim to optimize response patterns, in which informative voxels interacting with each other are selected, achieving high classification accuracy associated with cognitive stimulus conditions. To solve the problem, we propose a feature interaction detection framework, integrating hierarchical heterogeneous particle swarm optimization and support vector machines, for voxel selection in MVPA. In the proposed approach, we first select the most informative voxels and then identify a response pattern based on the connectivity of the selected voxels. The effectiveness of the proposed approach was examined for the Haxby's dataset of object-level representations. The computational results demonstrated higher classification accuracy by the extracted response patterns, compared to state-of-the-art feature selection algorithms, such as forward selection and backward selection.
authors.affiliation: Department of Systems Science & Industrial Engineering, Binghamton University, the State University of New York, Binghamton, USA.
authors.forename: Xinpei
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Systems Science & Industrial Engineering, Binghamton University, the State University of New York, Binghamton, USA. cachou@binghamton.edu.
authors.forename: Chun-An
authors.initials: CA
authors.lastname: Chou
authors.affiliation: Department of Systems Science & Industrial Engineering, Binghamton University, the State University of New York, Binghamton, USA.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Sayama
authors.affiliation: Departments of Industrial & Systems Engineering, Department of Radiology, Integrated Brain Imaging Center, University of Washington, Seattle, USA.|Department of Radiology, Integrated Brain Imaging Center, University of Washington, Seattle, USA.
authors.forename: Wanpracha Art
authors.initials: WA
authors.lastname: Chaovalitwongse
keywords: Brain functional connectivity; Brain response pattern; Feature selection; Interaction selection; Particle swarm optimization; Pattern classification