title: The significance of anthropometric and endocrine parameters in ovulation induction with clomiphene citrate in women with polycystic ovary syndrome.
abstract: To investigate factors associated with the response to ovarian stimulation in patients with polycystic ovary syndrome. Methods: The records of patients with polycystic ovary syndrome and infertility who underwent ovulation induction with clomiphene citrate were reviwed between January 2011 and December 2014 in Etlik Zübeyde Hanim Women's Health Training and Research Hospital Ankara, Turkey. The anthropometric and endocrine factors of patients who were resistant to treatment at a dose of 150 mg/day (n=84) were compared with those who responded with growth of at least one graaffian follicle at a dose of 50 mg/day (n=342). Results: Of the parameters examined, body mass index, luteinizing hormone level, and luteinizing hormone/follicle stimulating hormone ratio were significantly higher in the clomiphene citrate-resistant group compared with the responsive group. Conclusion: Reproductive treatment in patients with polycystic ovary syndrome show different outcomes. Significantly higher body mass index, luteinizing hormone level, and luteinizing hormone/follicle stimulating hormone ratio observed in clomiphene citrate resistant group can be a possible explanation for this impedance.
authors.affiliation: Department of Obstetrics and Gynecology, Etlik Zübeyde Hanım Women's Health Training and Research Hospital, Ankara, Turkey. E-mail. fundaakpinar@yahoo.com.
authors.forename: Funda
authors.initials: F
authors.lastname: Akpinar
authors.forename: Berna
authors.initials: B
authors.lastname: Dilbaz
authors.forename: Derya A
authors.initials: DA
authors.lastname: Cırık
authors.forename: Saynur
authors.initials: S
authors.lastname: Yilmaz
authors.forename: Sadiman
authors.initials: S
authors.lastname: Kiykac
authors.forename: Ertugrul
authors.initials: E
authors.lastname: Karahanoglu
authors.forename: Leyla
authors.initials: L
authors.lastname: Mollamahmutoglu
mesh_terms: D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002996:Clomiphene / Q000627:therapeutic use*; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007246:Infertility / Q000188:drug therapy* / Q000209:etiology; D007986:Luteinizing Hormone / Q000097:blood; D010062:Ovulation Induction / Q000379:methods*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014421:Turkey
chemical_list: D015415:Biomarkers; D005300:Fertility Agents, Female; D002996:Clomiphene; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone