title: Association of the rs9939609 gene variant in FTO with insulin resistance, cardiovascular risk factor and serum adipokine levels in obese patients.
abstract: BACKGROUND
  The aim of our study was to analyze the relationship of the rs9939609 FTO gene polymorphism with insulin resistance and serum adipokine levels.
  
  
  METHODS
  A population of 610 patients with obesity was analyzed in a cross sectional design. Weight, blood pressure, basal glucose, c-reactive protein (CRP), insulin, insulin resistance (HOMA), lipid profile and adipocytokines (leptin, adiponectin, resistin, TNF alpha, and interleukin 6) levels were measured.
  
  
  RESULTS
  Insulin (122.2 ± 101.8 pmol/L vs. 104.5 ± 61.5 pmol/L vs.112.1 ± 74.3 pmol/L:p < 0.05) and HOMA-IR values (4.76 ± 4.4 vs. 3.71 ± 2.5 vs.3.76 ± 3.1;p < 0.05) were higher in TT group than AT and AA groups. Triglycerides values were higher in TT group than AA group (1.42 ± 0.71 mmol/L vs.1.39 ± 0.69 mmol/L vs.1.23 ± 0.64 mmol/L;p < 0.05). Adiponectin levels were lower in TT genotype group than AA genotype group (35801.2 ± 35,912.3 ng/L vs.26,718.1 ± 36,323.1 ng/L vs. 21,112.3 ± 25,623.1 ng/L p < 0.05).
  
  
  CONCLUSIONS
  The FTO gene polymorphism, rs9939609, was found to be associated with insulin resistance, insulin, triglyceride and adiponectin levels in obese patients with TT variant.
authors.affiliation: Centro de Investigación de Endocrinología y Nutrición. Medicine School. Universidad de Valladolid. Valladolid, Spain. Department of Endocrinology and Nutrition. Hospital Clínico Universitario de Valladolid. Valladolid. dadluis@yahoo.es.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: De Luis
authors.forename: Rocío
authors.initials: R
authors.lastname: Aller
authors.forename: Olatz
authors.initials: O
authors.lastname: Izaola
authors.forename: David
authors.initials: D
authors.lastname: Primo
authors.forename: E
authors.initials: E
authors.lastname: Romero
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000235:genetics*; D003430:Cross-Sectional Studies; D005260:Female; D014644:Genetic Variation; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000235:genetics*; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D054392:Adipokines; D014280:Triglycerides; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human
keywords: Adipocytokines. Cardiovascular risk factors. Insulin  resistance to  rs9939609 gene  variant. Obesity.