title: [Study of the Relationship between Obesity and Lymphocytes in Breast Cancer Patients Undergoing Chemotherapy].
abstract: Obesitychanges the regulatorymechanisms of the immune system, resulting in impaired immunity. In cancer immune mechanisms, the greater the degree of obesity, the lower the activity of the lymphocytes. Herein, we examined the relationship between obesity and lymphocytes in breast cancer patients undergoing chemotherapy. We recruited 10 recurrent or metastatic breast cancer patients who were administered eribulin. Using bodymass index(BMI), we classified these patients into a non-obese group(BMI<25)and an obese group(BMI>25). We measured the number of lymphocytes before chemotherapy and 8 days after eribulin administration. We examined the decreasing rates of lymphocytes before and after eribulin administration in the 2 groups. The average age was 63.1 years. Non-obese and obese groups comprised 6 and 4 cases, respectively. The average rates of lymphocyte decrease before and after eribulin administration were 13.3%and 12.3% in the non-obese and obese groups, respectively. There were no significant differences between the 2 groups.
authors.affiliation: Division of Breast and Endocrine Surgery, Dept. of Surgery, Nihon University School of Medicine.
authors.forename: Keita
authors.initials: K
authors.lastname: Adachi
authors.forename: Shuhei
authors.initials: S
authors.lastname: Suzuki
authors.forename: Yuki
authors.initials: Y
authors.lastname: Masuo
authors.forename: Saki
authors.initials: S
authors.lastname: Nagashima
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Hara
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Hirano
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Enomoto
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sakurai
mesh_terms: D015992:Body Mass Index; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000209:etiology; D005663:Furans / Q000627:therapeutic use; D006801:Humans; D007659:Ketones / Q000627:therapeutic use; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000166:cytology*; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D000095662:Polyether Polyketides
chemical_list: D005663:Furans; D007659:Ketones; C490954:eribulin; D000095662:Polyether Polyketides