title: Budding transition of asymmetric two-component lipid domains.
abstract: We propose a model that accounts for the budding transition of asymmetric two-component lipid domains, where the two monolayers (leaflets) have different average compositions controlled by independent chemical potentials. Assuming a coupling between the local curvature and local lipid composition in each of the leaflets, we discuss the morphology and thermodynamic behavior of asymmetric lipid domains. The membrane free-energy contains three contributions: the bending energy, the line tension, and a Landau free-energy for a lateral phase separation. Within a mean-field treatment, we obtain various phase diagrams containing fully budded, dimpled, and flat states as a function of the two leaflet compositions. The global phase behavior is analyzed, and depending on system parameters, the phase diagrams include one-phase, two-phase, and three-phase regions. In particular, we predict various phase coexistence regions between different morphologies of domains, which may be observed in multicomponent membranes or vesicles.
authors.affiliation: Institut Charles Sadron, UPR22-CNRS 23, rue du Loess BP 84047, 67034 Strasbourg Cedex, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Wolff
authors.affiliation: Department of Chemistry, Graduate School of Science and Engineering, Tokyo Metropolitan University, Tokyo 192-0397, Japan.
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Komura
authors.affiliation: Raymond and Beverly Sackler School of Physics and Astronomy, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel and CAS Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: David
authors.initials: D
authors.lastname: Andelman
mesh_terms: D019277:Entropy; D008051:Lipid Bilayers / Q000378:metabolism; D008055:Lipids / Q000737:chemistry; D008954:Models, Biological; D013816:Thermodynamics
chemical_list: D008051:Lipid Bilayers; D008055:Lipids