title: Studying the CCN Proteins in Fibrosis.
abstract: CCN2 is a profibrotic matricellular protein. CCN2 directly promotes cell adhesion and indirectly promotes fibrosis by activating adhesive signaling in response to growth factors, cytokines, and extracellular matrix. The following protocols will allow the direct assessment of other CCN family members in these processes.
authors.affiliation: Departments of Dentistry and Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, Dental Sciences Building, London, ON, Canada, N6A 5C1.
authors.forename: James
authors.initials: J
authors.lastname: Hutchenreuther
authors.affiliation: Departments of Dentistry and Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, Dental Sciences Building, London, ON, Canada, N6A 5C1. Andrew.Leask@schulich.uwo.ca.
authors.forename: Andrew
authors.initials: A
authors.lastname: Leask
authors.affiliation: Departments of Dentistry and Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, Dental Sciences Building, London, ON, Canada, N6A 5C1.
authors.forename: Katherine
authors.initials: K
authors.lastname: Thompson
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000235:genetics; D003094:Collagen / Q000378:metabolism; D055513:Connective Tissue Growth Factor / Q000235:genetics* / Q000378:metabolism*; D005347:Fibroblasts / Q000378:metabolism; D005355:Fibrosis / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D055786:Gene Knockout Techniques; D051379:Mice; D008822:Mice, Transgenic; D012867:Skin / Q000378:metabolism / Q000473:pathology
chemical_list: D055513:Connective Tissue Growth Factor; D003094:Collagen
keywords: Adhesion; CCN1; CCN2; CCN3; CTGF; Conditional knockout; Contraction; Matricellular proteins; Nov; cyr61