title: Neuropathic Ulcers Among Children With Neural Tube Defects: A Review of Literature.
abstract: A trophic ulcer is a pressure ulcer caused by external trauma to a part of the body that is compromised due to disease, vascular insufficiency, or loss of afferent nerve fibers. Spinal dysraphism (ie, neural tube defects [NTD]) such as meningomyelocele is a risk factor for developing these ulcers in adults and pediatric patients. Information regarding the occurrence of trophic ulcers in pediatric patients with NTD is lacking. A review of the English-language literature on skin/neuropathic ulcers in patients with NTDs, irrespective of study design, published between 1975 and 2014, was undertaken using the PubMed database. Search terms included trophic ulcer, neuropathic ulcer, NTDs, and meningomyelocele. From among the more than 200 papers related to skin care in neonates and pediatric patients, 11 addressed skin ulcers in patients of NTD - 1 in French (a review article), 1 in German (a case report), and 9 in English (7 cohort studies and 2 reviewing surgical techniques). Typically, ulcers in patients with NTD are neuropathic (ie, related to nerve pathology). The most common type is meningomyelocele. Patients with NTD present with a spectrum of functional and sensory deficits that impair mobility; other causative factors that may contribute to the occurrence of ulcers include stress to the tissue, the length of time the stress occurs, muscle spasticity, infection, moisture, and nutritional status of the patient. Awareness of ulcer risk and preventive measures, such as maintaining foot flexibility or careful handling bony prominences such as kyphosis, is important. Once an ulcer occurs, management is challenging and involves collaboration of multiple medical, surgical, nutrition, and other specialists. If an ulcer develops and NTD has not been previously treated surgically or the MRI shows evidence of retethering, surgical treatment is needed. More research is needed to help guide ulcer prevention and treatment strategies in pediatric patients with NTD.
authors.affiliation: King George's Medical University, Lucknow, Uttar Pradesh, India.
authors.forename: Anand
authors.initials: A
authors.lastname: Pandey
authors.affiliation: UP Rural Institute of Medical Sciences and Research, Saifai, Etawah, Uttar Pradesh, India.
authors.forename: Vipin
authors.initials: V
authors.lastname: Gupta
authors.affiliation: UP Rural Institute of Medical Sciences and Research, Saifai, Etawah, Uttar Pradesh, India.
authors.forename: Shailendra P
authors.initials: SP
authors.lastname: Singh
authors.affiliation: UP Rural Institute of Medical Sciences and Research, Saifai, Etawah, Uttar Pradesh, India.
authors.forename: Vijendra
authors.initials: V
authors.lastname: Kumar
authors.affiliation: UP Rural Institute of Medical Sciences and Research, Saifai, Etawah, Uttar Pradesh, India.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Verma
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D009436:Neural Tube Defects / Q000150:complications*; D010372:Pediatrics / Q000379:methods; D012307:Risk Factors; D013131:Spine / Q000002:abnormalities / Q000503:physiopathology / Q000601:surgery; D014456:Ulcer / Q000150:complications / Q000209:etiology*; D014945:Wound Healing; D055815:Young Adult