title: High-molecular-weight HPMA-based polymer drug carriers for delivery to tumor.
abstract: In this work, design and synthesis of high-molecular-weight N-(2-hydroxypropyl)methacrylamide-based polymer drug delivery systems tailored for cancer therapy is summarized. Moreover, the influence of their architecture on tumor accumulation and in vivo anti-cancer efficacy is discussed. Mainly, the high-molecular-weight delivery systems, such as branched, grafted, multi-block, star-like or micellar systems, with molecular weights greater than the renal threshold are discussed and reviewed in detail.
authors.affiliation: Department of Biomedicinal Polymers, Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Prague, Czech Republic. kostka@imc.cas.cz.
authors.forename: L
authors.initials: L
authors.lastname: Kostka
authors.forename: T
authors.initials: T
authors.lastname: Etrych
mesh_terms: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008689:Methacrylates; D008823:Micelles; D053758:Nanoparticles; D011108:Polymers; D011355:Prodrugs
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008689:Methacrylates; D008823:Micelles; D011108:Polymers; D011355:Prodrugs; C032802:hydroxypropyl methacrylate