title: Bacteria From Marine Sponges: A Source of New Drugs.
abstract: BACKGROUND
  Sponges are rich source of bioactive natural products synthesized by the symbiotic bacteria belonging to different phyla. Due to a competition for space and nutrients the marine bacteria associated with sponges could produce more antibiotic substances. To explore the proactive potential of marine microbes extensive research has been done. These bioactive metabolites have some unique properties that are pharmaceutically important.
  
  
  METHODS
  For this review, we have performed a non-systematic search of the available literature though various online search engines. This review provides an insight that how majority of active metabolites have been identified from marine invertebrates of which sponges predominate.
  
  
  RESULTS
  Sponges harbor abundant and diverse microorganisms, which are the sources of a range of marine bioactive metabolites. From sponges and their associated microorganisms, approximately 5,300 different natural compounds are known. Current research on sponge-microbe interaction and their active metabolites has become a focal point for many researchers. Various active metabolites derived from sponges are now known to be produced by their symbiotic microflora.
  
  
  CONCLUSIONS
  In this review, we attempt to report the latest studies regarding capability of bacteria from sponges as producers of bioactive metabolite. Moreover, these sponge associated bacteria are an important source of different enzymes of industrial significance. In present review, we will address some novel approaches for discovering marine metabolites from bacteria that have the greatest potential to be used in clinical treatments.
authors.forename: Fehmida
authors.initials: F
authors.lastname: Bibi
authors.forename: Muhammad
authors.initials: M
authors.lastname: Faheem
authors.forename: Esam I
authors.initials: EI
authors.lastname: Azhar
authors.forename: Muhammad
authors.initials: M
authors.lastname: Yasir
authors.forename: Sana A
authors.initials: SA
authors.lastname: Alvi
authors.forename: Mohammad A
authors.initials: MA
authors.lastname: Kamal
authors.forename: Ikram
authors.initials: I
authors.lastname: Ullah
authors.affiliation: Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University Jeddah 21589, Saudi Arabia.
authors.forename: Muhammad I
authors.initials: MI
authors.lastname: Naseer
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D001419:Bacteria / Q000378:metabolism*; D001688:Biological Products; D055808:Drug Discovery / Q000379:methods*; D011161:Porifera / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D001688:Biological Products
keywords: Antimicrobial activity; hydrolytic enzymes; marine sponges; secondary metabolites; sponge-associated bacteria