title: Hyperpolarized Multi-Metal13C-Sensors for Magnetic Resonance Imaging.
abstract: We introduce hyperpolarizable13C-labeled probes that identify multiple biologically important divalent metals via metal-specific chemical shifts. These features enable NMR measurements of calcium concentrations in human serum in the presence of magnesium. In addition, signal enhancement through dynamic nuclear polarization (DNP) increases the sensitivity of metal detection to afford measuring micromolar concentrations of calcium as well as simultaneous multi-metal detection by chemical shift imaging. The hyperpolarizable13C-MRI sensors presented here enable sensitive NMR measurements and MR imaging of multiple divalent metals in opaque biological samples.
authors.affiliation: Institute for Biological and Medical Imaging & Institute of Developmental Genetics, Helmholtz Zentrum München , D-85764, Neuherberg, Germany.
authors.forename: Anurag
authors.initials: A
authors.lastname: Mishra
authors.affiliation: Institute for Biological and Medical Imaging & Institute of Developmental Genetics, Helmholtz Zentrum München , D-85764, Neuherberg, Germany.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Pariani
authors.affiliation: Microimaging Applications, Bruker , 76287 Rheinstetten, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Oerther
authors.affiliation: Department of Nuclear Medicine, Technical University of Munich (TUM) , Ismaninger Strasse 22, 81675 Munich, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Schwaiger
authors.affiliation: Department of Nuclear Medicine, Technical University of Munich (TUM) , Ismaninger Strasse 22, 81675 Munich, Germany.|Institute for Biological and Medical Imaging & Institute of Developmental Genetics, Helmholtz Zentrum München , D-85764, Neuherberg, Germany.
authors.forename: Gil G
authors.initials: GG
authors.lastname: Westmeyer