title: Patients with FGF23-related hypophosphatemic rickets/osteomalacia do not present with left ventricular hypertrophy.
abstract: OBJECTIVE
  Fibroblast growth factor 23 (FGF23) is a hormone regulating phosphate metabolism. Excessive actions of FGF23 cause several types of FGF23-related hypophosphatemic rickets/osteomalacia. Recently, it was reported that FGF23 levels were independently correlated with left ventricular hypertrophy (LVH) in patients with chronic kidney disease (CKD). In addition, FGF23 was also shown to cause cardiac hypertrophy directly acting on cardiomyocytes. However, there is no study indicating the correlation between FGF23 and LVH in adult patients with FGF23-related hypophosphatemic rickets/osteomalacia. Therefore, we examined the existence of LVH in these patients.
  
  
  METHODS
  We recruited consecutive 24 patients with FGF23-related hypophosphatemic diseases. Their serum intact FGF23 levels and the parameters associated with LVH, including left ventricular mass index (LVMI), relative wall thickness (RWT), Sokolow-Lyon voltage, and Cornell product, were measured. The correlations between FGF23 and these parameters were examined.
  
  
  RESULTS
  The participants did not show LVH on the whole. In addition, no significant correlation was observed by these examinations.
  
  
  CONCLUSIONS
  It seems unlikely that FGF23 levels are the apparent determinant of the cardiac mass in patients with FGF23-related hypophosphatemic rickets/osteomalacia.
authors.affiliation: a Division of Nephrology and Endocrinology , The University of Tokyo Hospital , Bunkyo-ku , Tokyo , Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Takashi
authors.affiliation: a Division of Nephrology and Endocrinology , The University of Tokyo Hospital , Bunkyo-ku , Tokyo , Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kinoshita
authors.affiliation: a Division of Nephrology and Endocrinology , The University of Tokyo Hospital , Bunkyo-ku , Tokyo , Japan.
authors.forename: Michiko
authors.initials: M
authors.lastname: Hori
authors.affiliation: a Division of Nephrology and Endocrinology , The University of Tokyo Hospital , Bunkyo-ku , Tokyo , Japan.
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Ito
authors.affiliation: a Division of Nephrology and Endocrinology , The University of Tokyo Hospital , Bunkyo-ku , Tokyo , Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Taguchi
authors.affiliation: a Division of Nephrology and Endocrinology , The University of Tokyo Hospital , Bunkyo-ku , Tokyo , Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Fukumoto
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010018:Osteomalacia / Q000097:blood*; D063730:Rickets, Hypophosphatemic / Q000097:blood*; D055815:Young Adult
chemical_list: C000717427:FGF23 protein, human; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23
keywords: FGF23-related hypophosphatemic rickets/osteomalacia; fibroblast growth factor 23; left ventricular hypertrophy