title: Comparison of Intraoperative γ-Probe Imaging and Postoperative SPECT/CT in Detection of Sentinel Nodes Related to the Ovary.
abstract: Tracer injection into ovarian ligaments has been shown to detect sentinel nodes (SNs) in patients with ovarian cancer. To determine the possibility that SNs are missed, this feasibility study compared their detection during surgery with their detection on postoperative SPECT/CT.
  
  
  METHODS
  In 8 patients (with either ovarian or endometrial cancer), after a staging lymphadenectomy including resection of SNs related to the ovary, SPECT/CT was performed within 24 h.
  
  
  RESULTS
  SPECT/CT identified hotspots in 4 patients at sites where SNs were resected. In 6 patients, additional sites were found, mainly in the pelvic region.
  
  
  CONCLUSIONS
  Discrepancies between the γ-probe and SPECT/CT may be due to missed SNs during surgery, but with respect to pelvic hotspots, in most cases they are more probably related to remnants of tracer at injection sites. With respect to sites where SNs were resected, remaining hotspots may have been caused by residual lymphatic flow after resection.
authors.affiliation: Department of Obstetrics and Gynaecology, Maastricht University Medical Centre, Maastricht, The Netherlands.
authors.forename: Stéphanie C J M
authors.initials: SC
authors.lastname: Speth
authors.affiliation: Department of Obstetrics and Gynaecology, Maastricht University Medical Centre, Maastricht, The Netherlands r.kruitwagen@mumc.nl.|GROW-School for Oncology and Developmental Biology, Maastricht, The Netherlands; and.
authors.forename: Roy F P M
authors.initials: RF
authors.lastname: Kruitwagen
authors.affiliation: Department of Obstetrics and Gynaecology, Maastricht University Medical Centre, Maastricht, The Netherlands.
authors.forename: Marjolein
authors.initials: M
authors.lastname: Kleppe
authors.affiliation: Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands.
authors.forename: Ivo N A
authors.initials: IN
authors.lastname: Pooters
authors.affiliation: Department of Obstetrics and Gynaecology, Maastricht University Medical Centre, Maastricht, The Netherlands.|GROW-School for Oncology and Developmental Biology, Maastricht, The Netherlands; and.
authors.forename: Toon
authors.initials: T
authors.lastname: Van Gorp
authors.affiliation: Department of Obstetrics and Gynaecology, Maastricht University Medical Centre, Maastricht, The Netherlands.|GROW-School for Oncology and Developmental Biology, Maastricht, The Netherlands; and.
authors.forename: Brigitte F M
authors.initials: BF
authors.lastname: Slangen
authors.affiliation: Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands.
authors.forename: Boudewijn
authors.initials: B
authors.lastname: Brans
mesh_terms: D000328:Adult; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery*; D011379:Prognosis; D011877:Radionuclide Imaging / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D000071036:Sentinel Lymph Node / Q000000981:diagnostic imaging*; D000072098:Single Photon Emission Computed Tomography Computed Tomography / Q000379:methods*; D025321:Surgery, Computer-Assisted / Q000379:methods*; D016896:Treatment Outcome
keywords: SPEC/CT; ovarian cancer; sentinel node