title: Effect of iron overload on renal functions and oxidative stress in beta thalassemia patients.
abstract: To check the amount of cellular damage caused by serial transfusions of blood in thalassemia patients.  Methods: A cross-sectional study was conducted in the University of Lahore, Lahore, Pakistan between August 2012 and December 2012. A total of 43 thalassemia patients underwent at least 10 blood transfusions. Comprehensive biochemical analysis of blood was performed to record the levels of creatinine, urea, uric acid, albumin, liver function tests, malondialdehyde (MDA), and ferritin.  Results: Serum creatinine (0.732±0.23mg/dl) and uric acid (6.7±0.94mg/dl, p less than 0.05) were significantly higher in patient groups as compared with the control. Ferritin levels were significantly higher in patients as compared with the control (3103.9±1747.4, p less than 0.05). Hemoglobin levels were observed in controls 14±1.3g/dl and in patients 7.1±1.03g/dl. No clear relationship exists between age and hematological parameters of thalassemic patients. Serum ferritin level is positively related with serum alanine transaminase, aspartate aminotransferase, and alkaline phosphatase and MDA (p less than 0.05).  Conclusion: Serum MDA and serum ferritin of patients (r=0.593, p less than 0.05) reflects that both are crucial parameters estimating the cellular damage in patients suffering from thalassemia.
authors.affiliation: Center of Excellence in Genomic Medicine and Research, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. E-mail. mahmoodrasool@yahoo.com.
authors.forename: Mahmood
authors.initials: M
authors.lastname: Rasool
authors.forename: Arif
authors.initials: A
authors.lastname: Malik
authors.forename: Uzma
authors.initials: U
authors.lastname: Jabbar
authors.forename: Irshad
authors.initials: I
authors.lastname: Begum
authors.forename: Mahmood H
authors.initials: MH
authors.lastname: Qazi
authors.forename: Muhammad
authors.initials: M
authors.lastname: Asif
authors.forename: Muhammad I
authors.initials: MI
authors.lastname: Naseer
authors.forename: Shakeel A
authors.initials: SA
authors.lastname: Ansari
authors.forename: Jummanah
authors.initials: J
authors.lastname: Jarullah
authors.forename: Absarul
authors.initials: A
authors.lastname: Haque
authors.forename: Mohammad S
authors.initials: MS
authors.lastname: Jamal
mesh_terms: D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood*; D003430:Cross-Sectional Studies; D005293:Ferritins / Q000097:blood*; D006801:Humans; D019190:Iron Overload / Q000150:complications*; D007668:Kidney / Q000378:metabolism*; D008111:Liver Function Tests; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress; D010154:Pakistan; D012709:Serum Albumin / Q000378:metabolism; D013789:Thalassemia / Q000097:blood / Q000150:complications* / Q000628:therapy*; D065227:Transfusion Reaction; D014495:Universities; D014508:Urea / Q000097:blood*; D014527:Uric Acid / Q000097:blood
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D012709:Serum Albumin; D014527:Uric Acid; D008315:Malondialdehyde; D014508:Urea; D005293:Ferritins; D003404:Creatinine