title: Reduction in Cerebral Oxygenation due to Patent Ductus Arteriosus Is Pronounced in Small-for-Gestational-Age Neonates.
abstract: A haemodynamically significant patent ductus arteriosus (hsPDA) reduces cerebral oxygenation in appropriate-for-gestational-age (AGA) preterm neonates. Reduced cerebral oxygenation has been associated with brain injury. Preterm small-for-gestational-age (SGA) neonates show higher cerebral oxygenation than AGA peers throughout the first postnatal days. To date, no studies have investigated the effect of hsPDA on cerebral oxygenation in preterm SGA neonates.
  
  
  
  We aimed to assess the effect of hsPDA on cerebral oxygenation in preterm SGA neonates compared to AGA peers. We hypothesised that higher baseline cerebral oxygenation would reduce the impact of hsPDA on cerebral oxygenation in preterm SGA neonates.
  
  
  
  We monitored regional cerebral oxygen saturation (rScO2) with near-infrared spectroscopy and calculated the cerebral fractional tissue oxygen extraction (cFTOE) for 72 h after birth. Retrospective analysis compared 36 preterm SGA neonates (birth weight <10th percentile, 18 with hsPDA) to 36 preterm AGA neonates (birth weight 20th to 80th percentile, 18 with hsPDA).
  
  
  
  In contrast to the other groups, SGA-hsPDA neonates demonstrated a significant fall in rScO2 [69% (SEM 2.5) at 4-8 h to 61% (2.7) at 68-72 h, p < 0.001] with a concurrent rise in cFTOE [0.26 (0.026) at 4-8 h to 0.34 (0.030) at 68-72 h, p < 0.001].
  
  
  
  Contrary to our hypothesis, hsPDA had a significant negative effect on cerebral oxygenation in preterm SGA neonates. Future studies should explore the potential benefits of early screening and treatment for hsPDA on long-term neurodevelopmental outcome in preterm SGA neonates.
authors.affiliation: Department of Neonatology, Wilhelmina Children's Hospital/University Medical Centre Utrecht, Utrecht, The Netherlands.
authors.forename: Emily
authors.initials: E
authors.lastname: Cohen
authors.forename: Laura
authors.initials: L
authors.lastname: Dix
authors.forename: Willem
authors.initials: W
authors.lastname: Baerts
authors.forename: Thomas
authors.initials: T
authors.lastname: Alderliesten
authors.forename: Petra
authors.initials: P
authors.lastname: Lemmers
authors.forename: Frank
authors.initials: F
authors.lastname: van Bel
mesh_terms: D001724:Birth Weight; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation; D004374:Ductus Arteriosus, Patent / Q000503:physiopathology*; D005260:Female; D005865:Gestational Age; D006439:Hemodynamics; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007236:Infant, Small for Gestational Age; D008297:Male; D008991:Monitoring, Physiologic; D009426:Netherlands; D010100:Oxygen / Q000032:analysis*; D012189:Retrospective Studies; D019265:Spectroscopy, Near-Infrared; D013997:Time Factors
chemical_list: D010100:Oxygen