title: Resveratrol Ameliorates the Depressive-Like Behaviors and Metabolic Abnormalities Induced by Chronic Corticosterone Injection.
abstract: Chronic glucocorticoid exposure is known to cause depression and metabolic disorders. It is critical to improve abnormal metabolic status as well as depressive-like behaviors in patients with long-term glucocorticoid therapy. This study aimed to investigate the effects of resveratrol on the depressive-like behaviors and metabolic abnormalities induced by chronic corticosterone injection. Male ICR mice were administrated corticosterone (40 mg/kg) by subcutaneous injection for three weeks. Resveratrol (50 and 100 mg/kg), fluoxetine (20 mg/kg) and pioglitazone (10 mg/kg) were given by oral gavage 30 min prior to corticosterone administration. The behavioral tests showed that resveratrol significantly reversed the depressive-like behaviors induced by corticosterone, including the reduced sucrose preference and increased immobility time in the forced swimming test. Moreover, resveratrol also increased the secretion of insulin, reduced serum level of glucose and improved blood lipid profiles in corticosterone-treated mice without affecting normal mice. However, fluoxetine only reverse depressive-like behaviors, and pioglitazone only prevent the dyslipidemia induced by corticosterone. Furthermore, resveratrol and pioglitazone decreased serum level of glucagon and corticosterone. The present results indicated that resveratrol can ameliorate depressive-like behaviors and metabolic abnormalities induced by corticosterone, which suggested that the multiple effects of resveratrol could be beneficial for patients with depression and/or metabolic syndrome associated with long-term glucocorticoid therapy.
authors.affiliation: College of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China. Liyucheng@hactcm.edu.cn.
authors.forename: Yu-Cheng
authors.initials: YC
authors.lastname: Li
authors.affiliation: College of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China. yamin62261@163.com.
authors.forename: Ya-Min
authors.initials: YM
authors.lastname: Liu
authors.affiliation: College of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China. lycdd1219@163.com.
authors.forename: Ji-Duo
authors.initials: JD
authors.lastname: Shen
authors.affiliation: College of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China. junjie102493@163.com.
authors.forename: Jun-Jie
authors.initials: JJ
authors.lastname: Chen
authors.affiliation: College of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China. 18203977548@163.com.
authors.forename: Yang-Yi
authors.initials: YY
authors.lastname: Pei
authors.affiliation: College of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China. Fxylele@yeah.net.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Fang
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D003345:Corticosterone / Q000009:adverse effects*; D003863:Depression / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D005473:Fluoxetine / Q000008:administration & dosage / Q000494:pharmacology; D008055:Lipids / Q000097:blood*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D000077205:Pioglitazone; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage* / Q000494:pharmacology; D013550:Swimming; D045162:Thiazolidinediones / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D000928:Antidepressive Agents; D001786:Blood Glucose; D008055:Lipids; D013267:Stilbenes; D045162:Thiazolidinediones; D005473:Fluoxetine; D000077185:Resveratrol; D003345:Corticosterone; D000077205:Pioglitazone
keywords: corticosterone; depression; metabolic abnormalities; resveratrol