title: Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery.
abstract: To commemorate the auspicious occasion of the 30th anniversary of IPC, leading pioneers in the field of cardioprotection gathered in Barcelona in May 2016 to review and discuss the history of IPC, its evolution to IPost and RIC, myocardial reperfusion injury as a therapeutic target, and future targets and strategies for cardioprotection. This article provides an overview of the major topics discussed at this special meeting and underscores the huge importance and impact, the discovery of IPC has made in the field of cardiovascular research.
authors.affiliation: The Hatter Cardiovascular Institute, University College London, London, UK. derek.hausenloy@duke-nus.edu.sg.|The National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, UK. derek.hausenloy@duke-nus.edu.sg.|Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, 8 College Road, Singapore, 169857, Singapore. derek.hausenloy@duke-nus.edu.sg.|National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore. derek.hausenloy@duke-nus.edu.sg.
authors.forename: Derek J
authors.initials: DJ
authors.lastname: Hausenloy
authors.affiliation: Department of Cardiology, Vall d'Hebron University Hospital and Research Institute, Universitat Autònoma, Barcelona, Spain.
authors.forename: Jose A
authors.initials: JA
authors.lastname: Barrabes
authors.affiliation: Department of Cardiology, Aarhus University Hospital Skejby, 8200, Aarhus N, Denmark.
authors.forename: Hans Erik
authors.initials: HE
authors.lastname: Bøtker
authors.affiliation: The Hatter Cardiovascular Institute, University College London, London, UK.
authors.forename: Sean M
authors.initials: SM
authors.lastname: Davidson
authors.affiliation: Department of Biomedical Sciences and CNR Institute of Neurosciences, University of Padova, Padua, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Di Lisa
authors.affiliation: Department of Physiology and Cell Biology, College of Medicine, University of South Alabama, Mobile, AL, USA.
authors.forename: James
authors.initials: J
authors.lastname: Downey
authors.affiliation: Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
authors.forename: Thomas
authors.initials: T
authors.lastname: Engstrom
authors.affiliation: Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary.|Pharmahungary Group, Szeged, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Ferdinandy
authors.affiliation: Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, 8 College Road, Singapore, 169857, Singapore.|National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore.|Institute for Biochemistry, Medical Faculty Justus-Liebig-University, Giessen, Germany.|Department of Microbiology, Kazan Federal University, Kazan, Russian Federation.
authors.forename: Hector A
authors.initials: HA
authors.lastname: Carbrera-Fuentes
authors.affiliation: Institute for Pathophysiology, West-German Heart and Vascular Center, University of Essen Medical School, Essen, Germany.
authors.forename: Gerd
authors.initials: G
authors.lastname: Heusch
authors.affiliation: Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.|IIS-Fundación Jiménez Díaz Hospital, Madrid, Spain.
authors.forename: Borja
authors.initials: B
authors.lastname: Ibanez
authors.affiliation: 2nd University Department of Cardiology, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Efstathios K
authors.initials: EK
authors.lastname: Iliodromitis
authors.affiliation: Department of Cardiology, Vall d'Hebron University Hospital and Research Institute, Universitat Autònoma, Barcelona, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Inserte
authors.affiliation: Duke University, Durham, NC, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Jennings
authors.affiliation: Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK.
authors.forename: Neena
authors.initials: N
authors.lastname: Kalia
authors.affiliation: Oxford Heart Centre, The John Radcliffe Hospital, Oxford University Hospitals, Oxford, UK.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Kharbanda
authors.affiliation: Department of Medicine, Hatter Institute for Cardiovascular Research in Africa and South African Medical Research Council Inter-University Cape Heart Group, Faculty of Health Sciences, University of Cape Town, Chris Barnard Building, Anzio Road, Observatory, Cape Town, Western Cape, 7925, South Africa.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Lecour
authors.affiliation: King's College London BHF Centre, The Rayne Institute, St. Thomas' Hospital, London, UK.
authors.forename: Michael
authors.initials: M
authors.lastname: Marber
authors.affiliation: Department of Cardiovascular, Renal, and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Miura
authors.affiliation: Explorations Fonctionnelles Cardiovasculaires, Hôpital Louis Pradel, Lyon, France.|UMR 1060 (CarMeN), Université Claude Bernard, Lyon 1, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Ovize
authors.affiliation: Cerebral Vascular Disease Research Laboratories, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.|Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.|Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Perez-Pinzon
authors.affiliation: Carl von Ossietzky Universität Oldenburg, Ökologiezentrum, Raum 2-116, Uhlhornsweg 99 b, 26129, Oldenburg, Germany.
authors.forename: Hans Michael
authors.initials: HM
authors.lastname: Piper
authors.affiliation: Department of Physiology and Emergency Medicine, Cardiovascular Research Institute, Wayne State University, Detroit, MI, USA.
authors.forename: Karin
authors.initials: K
authors.lastname: Przyklenk
authors.affiliation: Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, 8 College Road, Singapore, 169857, Singapore.
authors.forename: Michael Rahbek
authors.initials: MR
authors.lastname: Schmidt
authors.affiliation: Division of Cardiology, Department of Pediatrics, Heart Institute, Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Redington
authors.affiliation: Department of Cardiology, Vall d'Hebron University Hospital and Research Institute, Universitat Autònoma, Barcelona, Spain.
authors.forename: Marisol
authors.initials: M
authors.lastname: Ruiz-Meana
authors.affiliation: Cardiovascular Research Center, CSIC-ICCC, IIB-Hospital Sant Pau, c/Sant Antoni Maria Claret 167, 08025, Barcelona, Spain.
authors.forename: Gemma
authors.initials: G
authors.lastname: Vilahur
authors.affiliation: Division of Cardiothoracic Surgery, Department of Surgery, Emory University, Atlanta, USA.
authors.forename: Jakob
authors.initials: J
authors.lastname: Vinten-Johansen
authors.affiliation: The Hatter Cardiovascular Institute, University College London, London, UK.|The National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, UK.
authors.forename: Derek M
authors.initials: DM
authors.lastname: Yellon
authors.affiliation: Department of Cardiology, Vall d'Hebron University Hospital and Research Institute, Universitat Autònoma, Barcelona, Spain. dgdorado@vhebron.net.
authors.forename: David
authors.initials: D
authors.lastname: Garcia-Dorado
mesh_terms: D000818:Animals; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D015428:Myocardial Reperfusion Injury
keywords: Cardioprotection; Ischaemic conditioning; Mitochondria; Myocardial reperfusion injury; RISK and SAFE pathway