title: Retroviral restriction: nature's own solution.
abstract: The present review will discuss recent advances in the development of anti-HIV therapies inspired by studies of the mechanisms of host restriction factor-mediated resistance to HIV infection.
  
  
  
  Manipulating the interplay between host cell restriction factors and viral accessory factors that overcome them can potentially be therapeutically useful. Preliminarily successful therapies - some of which are entering clinical trials - either inhibit the ability of virus to evade restriction factor-mediated immunity, or promote intracellular levels of restriction factors. These aims are achieved by multiple means, which are discussed.
  
  
  
  Many restriction factors appear to provide potentially useful targets for anti-HIV therapies, so time and interest should be invested in investigating ways to successfully therapeutically manipulate restriction factor-mediated immunity.
authors.affiliation: The Centre for Immunobiology, Blizard Institute, Queen Mary University of London, London, UK.
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Jones
authors.forename: Áine
authors.initials: Á
authors.lastname: McKnight
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D015497:HIV-1; D006801:Humans; D057131:Immune Evasion; D007113:Immunity, Innate
chemical_list: D019380:Anti-HIV Agents; D044966:Anti-Retroviral Agents