title: Genetic Basis of Gastric Cancer.
abstract: Gastric cancer is the result of multiple risk factors, including environmental factors, genetic factors and the interaction between them. The environmental factors mainly include dietary, Helicobacter pylori infection and family history of gastric cancer. Genetic factors mainly refer to the susceptible genes that cause epigenetic alterations in oncogenes, tumor suppress genes, cell cycle regulators, DNA repair genes and signaling molecules. This paper summarizes the susceptible genes of gastric cancer and explores the genetic basis of it.
authors.affiliation: Department of Surgery, Rizhao People's Hospital, Rizhao, Shandong 276828, China.
authors.forename: Yue-Wen
authors.initials: YW
authors.lastname: Gao
authors.affiliation: Department of Surgery, Rizhao People's Hospital, Rizhao, Shandong 276828, China.
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Zhang
authors.affiliation: Department of Surgery, Rizhao People's Hospital, Rizhao, Shandong 276828, China.
authors.forename: Xing-Mei
authors.initials: XM
authors.lastname: Zuo
authors.affiliation: Department of Surgery, Rizhao People's Hospital, Rizhao, Shandong 276828, China.
authors.forename: Xi-Zeng
authors.initials: XZ
authors.lastname: Hui
mesh_terms: D050762:Cyclin-Dependent Kinase Inhibitor p15 / Q000235:genetics; D016147:Genes, Tumor Suppressor; D019942:Genes, p16; D006801:Humans; D009857:Oncogenes; D013274:Stomach Neoplasms / Q000209:etiology / Q000235:genetics*
chemical_list: D050762:Cyclin-Dependent Kinase Inhibitor p15