title: CaCO3/Tetraethylenepentamine-Graphene Hollow Microspheres as Biocompatible Bone Drug Carriers for Controlled Release.
abstract: CaCO3is one kind of important biological mineral, which widely exists in coral, shell, and other organisms. Since it is similar to bone tissue elements and has good biocompatibility, it was very suitable as a candidates for bone drug carriers. In this work, we used tetraethylenepentamine-graphene (rGO-TEPA) sheet matrices induction of CaCO3mineralization and successfully constructed CaCO3/rGO-TEPA drug carriers with a hollow structure and rough surface. As potential drug carriers, doxorubicin (DOX) loading and release measurements were carried out. It showed that load efficiency was 94.7% and the release efficiencies were 13.8% and 91.7% at values of pH 7.4 and 5.0. The as-prepared drug carriers showed some appealing advantages, such as the pH-sensitive release characteristics and mild storage-release behaviors. The excellent biocompatibility and nontoxicity of CaCO3/rGO-TEPA hybrid microspheres were tested by the cell viability of mouse preosteoblast cells (MC3T3-E1). And cytotoxicity with human osteosarcoma cells (MG-63) was carried out to demonstrate the drug release effect in the cells system. Therefore, the CaCO3/rGO-TEPA hybrid microspheres would be a competitive alternative in bone drug carriers.
authors.affiliation: Key Laboratory of Superlight Material and Surface Technology of Ministry of Education, College of Material Science and Chemical Engineering, Harbin Engineering University , Harbin 150001, China.|Key Laboratory for Green Chemical Technology of Ministry of Education, School of Chemical Engineering and Technology, Tianjin University , Tianjin 300072, China.|Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , Tianjin 300072, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: Key Laboratory of Superlight Material and Surface Technology of Ministry of Education, College of Material Science and Chemical Engineering, Harbin Engineering University , Harbin 150001, China.
authors.forename: Hongkun
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Key Laboratory of Superlight Material and Surface Technology of Ministry of Education, College of Material Science and Chemical Engineering, Harbin Engineering University , Harbin 150001, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Ouyang
authors.affiliation: Key Laboratory of Superlight Material and Surface Technology of Ministry of Education, College of Material Science and Chemical Engineering, Harbin Engineering University , Harbin 150001, China.
authors.forename: Shihui
authors.initials: S
authors.lastname: Han
authors.affiliation: Key Laboratory of Superlight Material and Surface Technology of Ministry of Education, College of Material Science and Chemical Engineering, Harbin Engineering University , Harbin 150001, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Tumor Hospital of Harbin Medical University , Harbin 150081, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Xie
authors.affiliation: Tumor Hospital of Harbin Medical University , Harbin 150081, China.
authors.forename: Wenting
authors.initials: W
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Superlight Material and Surface Technology of Ministry of Education, College of Material Science and Chemical Engineering, Harbin Engineering University , Harbin 150001, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Ma
authors.affiliation: Key Laboratory of Superlight Material and Surface Technology of Ministry of Education, College of Material Science and Chemical Engineering, Harbin Engineering University , Harbin 150001, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wei
authors.affiliation: Key Laboratory for Green Chemical Technology of Ministry of Education, School of Chemical Engineering and Technology, Tianjin University , Tianjin 300072, China.|Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , Tianjin 300072, China.
authors.forename: Zhongyi
authors.initials: Z
authors.lastname: Jiang
mesh_terms: D000818:Animals; D002119:Calcium Carbonate; D003692:Delayed-Action Preparations; D004317:Doxorubicin; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005029:Ethylenediamines; D006108:Graphite; D006801:Humans; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008863:Microspheres
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005029:Ethylenediamines; D006108:Graphite; D004317:Doxorubicin; D002119:Calcium Carbonate; C034269:tetraethylenepentamine
keywords: CaCO3; bone drug carriers; doxorubicin; drug delivery; rGO-TEPA