title: Somatostatin-secreting Pheochromocytoma Mimicking Insulin-dependent Diabetes Mellitus.
abstract: We herein present the findings of a 42-year-old woman with either adrenal pheochromocytoma or intraadrenal paraganglioma that simultaneously secreted somatostatin, thus mimicking insulin-dependent diabetes mellitus. Pheochromocytoma was clinically diagnosed based on scintigraphy, elevated catecholamine levels, and finally a histopathological analysis of resected specimens. The patient had diabetic ketosis, requiring 40 U insulin for treatment. Following laparoscopic adrenalectomy, insulin therapy was discontinued and the urinary c-peptide levels changed from 5.5-9.0 to 81.3-87.0 μg/day. Histologically, somatostatin immunoreactivity was detected and the somatostatin levels were elevated in the serum-like fluid obtained from the tumor. Clinicians should be aware of the possible occurrence of simultaneous ectopic hormone secretion in patients with pheochromocytoma.
authors.affiliation: Department of Nephrology, Hypertension, Diabetology, Endocrinology, and Metabolism, Fukushima Medical University, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hirai
authors.forename: Sanae
authors.initials: S
authors.lastname: Midorikawa
authors.forename: Shinichi
authors.initials: S
authors.lastname: Suzuki
authors.forename: Hironobu
authors.initials: H
authors.lastname: Sasano
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Watanabe
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Satoh
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000628:therapy; D000315:Adrenalectomy; D000328:Adult; D002096:C-Peptide / Q000652:urine; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D010535:Laparoscopy; D010673:Pheochromocytoma / Q000175:diagnosis* / Q000378:metabolism* / Q000628:therapy; D013004:Somatostatin / Q000378:metabolism*
chemical_list: D002096:C-Peptide; D007004:Hypoglycemic Agents; D007328:Insulin; D013004:Somatostatin