title: Metastatic Gastrointestinal Adenocarcinoma with Osteoblastic Activity: A Case Report of Esophageal and Colonic Primaries.
abstract: Adenocarcinoma with osteoblastic metastases is classically seen in prostate, breast, and lung primaries. Less common primary sites include thyroid, kidney, and stomach. We present two cases of primary gastrointestinal adenocarcinoma with metastatic osteoblastic activity from two previously unreported sites. The first case represents an esophageal adenocarcinoma arising in a background of intestinal metaplasia that metastasized with osteoblastic activity to the deltoid muscle. The second case demonstrates a Stage IV sigmoid colon adenocarcinoma with osteoblastic metastases to the liver and lymph nodes. The findings indicate that metastases from various gastrointestinal primary adenocarcinomas can have prominent bone formation.
authors.affiliation: Department of Pathology, University of California, San Diego, 200 West Arbor Drive, MC 8320, San Diego, CA 92103, USA.
authors.forename: Brett Matthew
authors.identifier: 0000-0002-5457-1381
authors.initials: BM
authors.lastname: Lowenthal
authors.affiliation: Department of Pathology, University of California, San Diego, 200 West Arbor Drive, MC 8320, San Diego, CA 92103, USA.
authors.forename: Ahmed S
authors.initials: AS
authors.lastname: Shabaik
authors.affiliation: Department of Pathology, University of California, San Diego, 200 West Arbor Drive, MC 8320, San Diego, CA 92103, USA.
authors.forename: Mark A
authors.identifier: 0000-0003-1721-3451
authors.initials: MA
authors.lastname: Valasek