title: Lactate as a Signaling Molecule That Regulates Exercise-Induced Adaptations.
abstract: Lactate (or its protonated form: lactic acid) has been studied by many exercise scientists. The lactate paradigm has been in constant change since lactate was first discovered in 1780. For many years, it was unfairly seen as primarily responsible for muscular fatigue during exercise and a waste product of glycolysis. The status of lactate has slowly changed to an energy source, and in the last two decades new evidence suggests that lactate may play a much bigger role than was previously believed: many adaptations to exercise may be mediated in some way by lactate. The mechanisms behind these adaptations are yet to be understood. The aim of this review is to present the state of lactate science, focusing on how this molecule may mediate exercise-induced adaptations.
authors.affiliation: Graduate School of Sports and Health Science, Doshisha University, Kyoto 610-0394, Japan. dhp0005@mail4.doshisha.ac.jp.
authors.forename: Minas
authors.initials: M
authors.lastname: Nalbandian
authors.affiliation: Faculty of Sports and Health Science, Doshisha University, Kyoto 610-0394, Japan. mtakeda@mail.doshisha.ac.jp.
authors.forename: Masaki
authors.initials: M
authors.lastname: Takeda
keywords: HIF-1; PGC-1 alpha; lactate; signaling molecule