title: Re-energizing the Development of Pain Therapeutics in Light of the Opioid Epidemic.
abstract: Limited options for treating moderate-severe pain led to an overreliance on opioids and the current opioid epidemic. Addressing the factors contributing to a dearth of effective alternatives and re-energizing the development of pain therapeutics is necessary to quell this epidemic.
authors.affiliation: Division of Therapeutics and Medical Consequences, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Phil
authors.initials: P
authors.lastname: Skolnick
authors.affiliation: Office of the Director, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: nvolkow@nida.nih.gov.
authors.forename: Nora D
authors.initials: ND
authors.lastname: Volkow
mesh_terms: D059787:Acute Pain / Q000188:drug therapy; D000700:Analgesics / Q000627:therapeutic use*; D000701:Analgesics, Opioid / Q000627:therapeutic use; D059350:Chronic Pain / Q000188:drug therapy*; D055808:Drug Discovery; D058872:Epidemics; D006801:Humans; D009293:Opioid-Related Disorders / Q000453:epidemiology*; D059408:Pain Management; D010647:Phenyl Ethers / Q000627:therapeutic use; D000069583:Pregabalin / Q000627:therapeutic use; D011392:Proline / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D000700:Analgesics; D000701:Analgesics, Opioid; D010647:Phenyl Ethers; D000069583:Pregabalin; D011392:Proline; C000592131:vixotrigine