title: The Signature of Maternal Social Rank in Placenta Deoxyribonucleic Acid Methylation Profiles in Rhesus Monkeys.
abstract: The effects of social status on human health can be modeled in captive cohorts of nonhuman primates. This study shows that maternal social rank is associated with broad changes in DNA methylation in placentae of rhesus monkeys (N = 10). Differentially methylated genes between social ranks are enriched in signaling pathways playing major roles in placenta physiology. Moreover, the authors found significant overlaps with genes whose expression was previously associated with social rank in adult rhesus monkeys (Tung et al., 2012) and whose methylation was associated with perinatal stress in newborn humans and rhesus monkeys (Nieratschker et al., 2014). These results are consistent with the hypothesis that system-wide epigenetic changes in multiple tissues are involved in long-term adaptations to the social environment.
authors.affiliation: McGill University.
authors.forename: Renaud
authors.initials: R
authors.lastname: Massart
authors.affiliation: McGill University.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Suderman
authors.affiliation: McGill University.
authors.forename: Zsofia
authors.identifier: 0000-0002-9550-7730
authors.initials: Z
authors.lastname: Nemoda
authors.affiliation: National Institutes of Health.
authors.forename: Sheila
authors.initials: S
authors.lastname: Sutti
authors.affiliation: National Institutes of Health.
authors.forename: Angela M
authors.initials: AM
authors.lastname: Ruggiero
authors.affiliation: National Institutes of Health.
authors.forename: Amanda M
authors.initials: AM
authors.lastname: Dettmer
authors.affiliation: National Institutes of Health.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Suomi
authors.affiliation: McGill University.
authors.forename: Moshe
authors.initials: M
authors.lastname: Szyf
mesh_terms: D000818:Animals; D019175:DNA Methylation; D005260:Female; D008253:Macaca mulatta / Q000235:genetics / Q000378:metabolism; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D012930:Social Dominance