title: Introduction to the Theme "New Methods and Novel Therapeutic Approaches in Pharmacology and Toxicology".
abstract: Major advances in scientific discovery and insights can result from the development and use of new techniques, as exemplified by the work of Solomon Snyder, who writes a prefatory article in this volume. The Editors have chosen "New Methods and Novel Therapeutic Approaches in Pharmacology and Toxicology" as the Theme for a number of articles in this volume. These include ones that review the development and use of new experimental tools and approaches (e.g., nanobodies and techniques to explore protein-protein interactions), new types of therapeutics (e.g., aptamers and antisense oligonucleotides), and systems pharmacology, which assembles (big) data derived from omics studies together with information regarding drugs and patients. The application of these new methods and therapeutic approaches has the potential to have a major impact on basic and clinical research in pharmacology and toxicology as well as on patient care.
authors.affiliation: Department of Pharmacology, University of California, San Diego, La Jolla, California 92093.|Department of Medicine, University of California, San Diego, La Jolla, California 92093.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Insel
authors.affiliation: National Institute of Mental Health, Bethesda, Maryland 20892.
authors.forename: Susan G
authors.initials: SG
authors.lastname: Amara
authors.affiliation: Department of Medicine, Stanford University School of Medicine, Stanford, California 94305.
authors.forename: Terrence F
authors.initials: TF
authors.lastname: Blaschke
authors.affiliation: Biozentrum, University of Basel, CH-4056 Basel, Switzerland.
authors.forename: Urs A
authors.initials: UA
authors.lastname: Meyer
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000379:methods* / Q000639:trends; D006801:Humans; D010600:Pharmacology / Q000379:methods* / Q000639:trends; D014116:Toxicology / Q000379:methods* / Q000639:trends