title: [Plasmapheresis failure in the treatment of auto-immune pulmonary alveolar proteinosis].
abstract: BACKGROUND
  Auto-immune pulmonary alveolar proteinosis is a rare disorder characterized by the accumulation of surfactant proteins in the alveoli.
  
  
  METHODS
  We report a case of a 41-year-old smoker, presenting initially with acute respiratory failure. Whole lung lavages were effective initially but only for a few weeks. GM-CSF subcutaneous injections were not effective, and then plasmapheresis were tried.
  
  
  CONCLUSIONS
  This is the fifth report of the use of this treatment in auto-immune pulmonary alveolar proteinosis. Plasmapheresis was not effective in our patient.
authors.affiliation: Service de pneumologie, hôpital Pontchaillou, 35000 Rennes, France. Electronic address: antoine.jezequel@chu-rennes.fr.
authors.forename: A
authors.initials: A
authors.lastname: Jézéquel
authors.affiliation: Service de pneumologie, hôpital Pontchaillou, 35000 Rennes, France.
authors.forename: M
authors.initials: M
authors.lastname: Kerjouan
authors.affiliation: Service de radiologie, hôpital Pontchaillou, 35000 Rennes, France.
authors.forename: M
authors.initials: M
authors.lastname: Lederlin
authors.affiliation: Service d'immunologie, thérapie cellulaire et hématopoïèse, hôpital Pontchaillou, 35000 Rennes, France.
authors.forename: C
authors.initials: C
authors.lastname: Lainé-Caroff
authors.affiliation: Service de réanimation médicale, hôpital Pontchaillou, 35000 Rennes, France.
authors.forename: C
authors.initials: C
authors.lastname: Camus
authors.affiliation: Service de pneumologie, hôpital Pontchaillou, 35000 Rennes, France; IRSET UMR 1085, université de Rennes 1, 35000 Rennes, France.
authors.forename: P
authors.initials: P
authors.lastname: Delaval
authors.affiliation: Service de pneumologie, hôpital Pontchaillou, 35000 Rennes, France; IRSET UMR 1085, université de Rennes 1, 35000 Rennes, France.
authors.forename: S
authors.initials: S
authors.lastname: Jouneau
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008297:Male; D010956:Plasmapheresis; D011649:Pulmonary Alveolar Proteinosis / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D013902:Radiography, Thoracic; D012128:Respiratory Distress Syndrome / Q000175:diagnosis / Q000209:etiology / Q000473:pathology / Q000628:therapy; D017211:Treatment Failure
keywords: GM-CSF; Grand lavage pulmonaire thérapeutique; Plasma exchanges; Plasmapheresis; Plasmaphérèse; Protéinose alvéolaire pulmonaire; Pulmonary alveolar proteinosis; Whole lung lavage; Échanges plasmatiques