title: Gene polymorphisms are associated with clinical outcome in Chinese resected laryngeal carcinoma patients.
abstract: We examined the multigenetic index on the progression of laryngeal carcinoma in Chinese population. This study aims to assess the effects of single nucleotide polymorphisms (SNPs) on survival of Laryngeal Carcinoma (LC) patients. Eighteen SNPs were selected and genotyped using the Sequenom iPLEX genotyping system in a cohort of 170 resected Chinese LC patients. Multivariate Cox proportional hazards model and Kaplan-Meier curve were used for the prognosis analysis. Overall, the median survival time (MST) was 38.00 months. The one, three and five year Kaplan-Meier survival rate was 0.847 ± 0.028, 0.572 ± 0.038 and 0.471 ± 0.041 respectively. The risks of death with the Hazard Ratio (HR) [95% confidence intervals] (CI) of 2.40 (1.15-4.50), 2.17 (1.45-3.25), 2.39 (1.58-3.62), 3.29 (2.10-5.18), respectively. There was significant associations between the SNPs and OS when the entire study population was examined. The rs1321311 TG genotype (vs.GG), rs2494938 AA genotype (vs. GG) and rs9363918 TG genotype (vs. GG) were associated with a worse prognosis for OS (adjusted HR = 1.64; 95%confidence interval = 1.07-2.51; P = 0.022, adjusted HR = 2.85; P =0.12; adjusted HR = 1.78; P = 0.009; respectively).The results suggest for the first time that these gene polymorphisms may serve as an independent prognostic marker for LC patients.
authors.affiliation: The National Engineering Research Centre for Miniaturized Detection Systems, College of Life Science, Northwest University, Xi'an, Shaanxi 710069, China.|Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, Shaanxi 710069, China.|Institution of Basic Medical Science, Xi'an Medical University, Xi'an, Shaanxi 710021, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Chen
authors.affiliation: The National Engineering Research Centre for Miniaturized Detection Systems, College of Life Science, Northwest University, Xi'an, Shaanxi 710069, China.|Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, Shaanxi 710069, China.
authors.forename: Zhengshuai
authors.initials: Z
authors.lastname: Chen
authors.affiliation: The National Engineering Research Centre for Miniaturized Detection Systems, College of Life Science, Northwest University, Xi'an, Shaanxi 710069, China.|Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, Shaanxi 710069, China.
authors.forename: Jinglie
authors.initials: J
authors.lastname: Li
authors.affiliation: The National Engineering Research Centre for Miniaturized Detection Systems, College of Life Science, Northwest University, Xi'an, Shaanxi 710069, China.|Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, Shaanxi 710069, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
authors.affiliation: Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, Shaanxi 710069, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, Shaanxi 710069, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.affiliation: The National Engineering Research Centre for Miniaturized Detection Systems, College of Life Science, Northwest University, Xi'an, Shaanxi 710069, China.|Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, Shaanxi 710069, China.
authors.forename: Mengdan
authors.initials: M
authors.lastname: Yan
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Xi'an, Jiaotong University, Xi'an, Shaanxi 710061, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Shao
authors.affiliation: The National Engineering Research Centre for Miniaturized Detection Systems, College of Life Science, Northwest University, Xi'an, Shaanxi 710069, China.|Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, Shaanxi 710069, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.affiliation: The National Engineering Research Centre for Miniaturized Detection Systems, College of Life Science, Northwest University, Xi'an, Shaanxi 710069, China.|Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, Shaanxi 710069, China.
authors.forename: Tianbo
authors.initials: T
authors.lastname: Jin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000235:genetics; D005838:Genotype; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000401:mortality; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D016016:Proportional Hazards Models; D044767:Ubiquitin-Protein Ligases / Q000235:genetics
chemical_list: C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein
keywords: laryngeal carcinoma; overall survival; prognosis; prognostic marker; single-nucleotide polymorphism