title: [Cervical cancer : Update on morphology].
abstract: The World Health Organization (WHO) classification from 2014 differentiates between different subtypes of mucinous adenocarcinoma of the uterine cervix. A gastric subtype was recently described that showed no association with high-risk human papillomavirus (HPV) infections, has a poor prognosis, is mainly diagnosed in women of Asian origin and can occur in patients with Peutz-Jeghers syndrome. Although no clear grading system has been recommended in the WHO classification, it is likely that grading of adenocarcinomas of the uterine cervix will partly be based on the different patterns of invasion. Deep stromal infiltration of macroinvasive carcinomas is defined as an infiltration of >66 % of the cervical stroma. In the near future a maximum tumor size of 2 cm could act as a discriminator for planning of less radical surgery. Parameters of the histopathological report that are relevant for the prognostic assessment as well as the choice of adjuvant treatment and function as quality indicators during certification are described. The histological type of an adenocarcinoma alone is of no predictive or prognostic relevance for patients undergoing primary surgical treatment, neoadjuvant chemotherapy, combined chemo-radiotherapy or treatment with angiogenesis inhibitors. Currently, molecular parameters and biomarkers are of no relevance.
authors.affiliation: Abteilung Mamma-, Gynäko- und Perinatalpathologie, Institut für Pathologie, Universitätsklinikum Leipzig AöR, Liebigstraße 26, 04103, Leipzig, Deutschland. hornl@medizin.uni-leipzig.de.
authors.forename: L-C
authors.initials: LC
authors.lastname: Horn
authors.affiliation: Frauenklinik des Klinikums rechts der Isar, Technische Universität München, München, Deutschland.
authors.forename: C E
authors.initials: CE
authors.lastname: Brambs
authors.affiliation: Universitätsfrauenklinik Leipzig (Triersches Institut) im Zentrum für Frauen- und Kindermedizin, Universitätsklinikum Leipzig AöR, Leipzig, Deutschland.
authors.forename: R
authors.initials: R
authors.lastname: Handzel
authors.affiliation: Institut für Pathologie, Landeskrankenhaus Graz Süd-West, Graz, Österreich.
authors.forename: S
authors.initials: S
authors.lastname: Lax
authors.affiliation: Abteilung Mamma-, Gynäko- und Perinatalpathologie, Institut für Pathologie, Universitätsklinikum Leipzig AöR, Liebigstraße 26, 04103, Leipzig, Deutschland.
authors.forename: I
authors.initials: I
authors.lastname: Sändig
authors.affiliation: Institut für Pathologie, Viersen, Deutschland.
authors.forename: D
authors.initials: D
authors.lastname: Schmidt
authors.affiliation: Abteilung Mamma-, Gynäko- und Perinatalpathologie, Institut für Pathologie, Universitätsklinikum Leipzig AöR, Liebigstraße 26, 04103, Leipzig, Deutschland.
authors.forename: K
authors.initials: K
authors.lastname: Schierle
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000145:classification* / Q000473:pathology* / Q000628:therapy; D014408:Biomarkers, Tumor / Q000032:analysis; D002584:Cervix Uteri / Q000473:pathology*; D003131:Combined Modality Therapy; D005260:Female; D052162:Human papillomavirus 16 / Q000472:pathogenicity; D006801:Humans; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D030361:Papillomavirus Infections / Q000145:classification / Q000473:pathology / Q000628:therapy; D057089:Pathology, Molecular; D011379:Prognosis; D019984:Quality Indicators, Health Care; D002583:Uterine Cervical Neoplasms / Q000145:classification / Q000473:pathology* / Q000628:therapy; D014594:Uterine Neoplasms / Q000145:classification* / Q000473:pathology*; D014599:Uterus / Q000473:pathology; D014944:World Health Organization
chemical_list: D014408:Biomarkers, Tumor
keywords: Adenocarcinoma; Biomarkers; Grading; Molecular pathology; Quality indicators