title: Amazing structure of respirasome: unveiling the secrets of cell respiration.
abstract: Respirasome, a huge molecular machine that carries out cellular respiration, has gained growing attention since its discovery, because respiration is the most indispensable biological process in almost all living creatures. The concept of respirasome has renewed our understanding of the respiratory chain organization, and most recently, the structure of respirasome solved by Yang's group from Tsinghua University (Gu et al. Nature 237(7622):639-643, 2016) firstly presented the detailed interactions within this huge molecular machine, and provided important information for drug design and screening. However, the study of cellular respiration went through a long history. Here, we briefly showed the detoured history of respiratory chain investigation, and then described the amazing structure of respirasome.
authors.affiliation: Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
authors.forename: Runyu
authors.initials: R
authors.lastname: Guo
authors.affiliation: Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
authors.forename: Jinke
authors.initials: J
authors.lastname: Gu
authors.affiliation: Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Wu
authors.affiliation: Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, 100084, China. maojunyang@tsinghua.edu.cn.
authors.forename: Maojun
authors.identifier: http://orcid.org/0000-0002-6798-3094
authors.initials: M
authors.lastname: Yang
mesh_terms: D000818:Animals; D004579:Electron Transport / Q000502:physiology; D045222:Electron Transport Chain Complex Proteins / Q000737:chemistry* / Q000266:history / Q000378:metabolism; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D020836:Protein Structure, Quaternary; D013329:Structure-Activity Relationship
chemical_list: D045222:Electron Transport Chain Complex Proteins
keywords: cellular respiration; megacomplex; respirasome structure; respiratory complexes; supercomplexes organization