title: IL-3 promotes the development of experimental autoimmune encephalitis.
abstract: Little is known about the role of IL-3 in multiple sclerosis (MS) in humans and in experimental autoimmune encephalomyelitis (EAE). Using myelin oligodendrocyte glycoprotein (MOG) peptide-induced EAE, we show that CD4+T cells are the main source of IL-3 and that cerebral IL-3 expression correlates with the influx of T cells into the brain. Blockade of IL-3 with monoclonal antibodies, analysis of IL-3 deficient mice, and adoptive transfer of leukocytes demonstrate that IL-3 plays an important role for development of clinical symptoms of EAE, for migration of leukocytes into the brain, and for cerebral expression of adhesion molecules and chemokines. In contrast, injection of recombinant IL-3 exacerbates EAE symptoms and cerebral inflammation. In patients with relapsing-remitting MS (RRMS), IL-3 expression by T cells is markedly upregulated during episodes of relapse. Our data indicate that IL-3 plays an important role in EAE and may represent a new target for treatment of MS.
authors.affiliation: Department of Internal Medicine II - Nephrology.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Renner
authors.affiliation: Department of Internal Medicine II - Nephrology.
authors.forename: Sonja
authors.initials: S
authors.lastname: Hellerbrand
authors.affiliation: Department of Internal Medicine II - Nephrology.
authors.forename: Fabian
authors.initials: F
authors.lastname: Hermann
authors.affiliation: Department of Neurology.
authors.forename: Christine
authors.initials: C
authors.lastname: Riedhammer
authors.affiliation: Department of Internal Medicine II - Nephrology.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Talke
authors.affiliation: Department of Internal Medicine II - Nephrology.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Schiechl
authors.affiliation: Department of Internal Medicine II - Nephrology.
authors.forename: Manuel
authors.initials: M
authors.lastname: Rodriguez Gomez
authors.affiliation: Department of Internal Medicine II - Nephrology.
authors.forename: Simone
authors.initials: S
authors.lastname: Kutzi
authors.affiliation: Department of Neurology.
authors.forename: Dagmar
authors.initials: D
authors.lastname: Halbritter
authors.affiliation: Department of Internal Medicine II - Nephrology.
authors.forename: Nicole
authors.initials: N
authors.lastname: Goebel
authors.affiliation: Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany.
authors.forename: Hilke
authors.initials: H
authors.lastname: Brühl
authors.affiliation: Department of Neurology.|Regensburg Center for Interventional Immunology, Regensburg, Germany.
authors.forename: Robert
authors.initials: R
authors.lastname: Weissert
authors.affiliation: Department of Internal Medicine II - Nephrology.|Regensburg Center for Interventional Immunology, Regensburg, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Mack
mesh_terms: D019264:Adoptive Transfer; D000328:Adult; D000818:Animals; D000911:Antibodies, Monoclonal; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000378:metabolism; D018925:Chemokines / Q000378:metabolism; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000139:chemically induced / Q000276:immunology*; D005260:Female; D006801:Humans; D007377:Interleukin-3 / Q000037:antagonists & inhibitors / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009103:Multiple Sclerosis / Q000276:immunology*; D063308:Myelin-Oligodendrocyte Glycoprotein
chemical_list: D000911:Antibodies, Monoclonal; D015815:Cell Adhesion Molecules; D018925:Chemokines; D007377:Interleukin-3; D063308:Myelin-Oligodendrocyte Glycoprotein