title: Detection Rate, Distribution, Clinical and Pathological Features of Colorectal Serrated Polyps.
abstract: BACKGROUND
  Colorectal serrated polyp is considered as histologically heterogeneous lesions with malignant potential in western countries. However, few Asian studies have investigated the comprehensive clinical features of serrated polyps in symptomatic populations. The aim of the study was to evaluate the features of colorectal serrated polyps in a Chinese symptomatic population.
  
  
  METHODS
  Data from all consecutive symptomatic patients were documented from a large colonoscopy database and were analyzed. Chi-square test or Fisher's exact test and logistic regression analysis were used for the data processing.
  
  
  RESULTS
  A total of 9191 (31.7%) patients were detected with at least one colorectal polyp. The prevalence of serrated polyps was 0.53% (153/28,981). The proportions of hyperplastic polyp (HP), sessile serrated adenoma/polyp (SSA/P), and traditional serrated adenoma (TSA) of all serrated polyps were 41.2%, 7.2%, and 51.6%, respectively, which showed a lower proportion of HP and SSA/P and a higher proportion of TSA. Serrated polyps appeared more in males and elder patients while there was no significant difference in the subtype distribution in gender and age. The proportions of large and proximal serrated polyps were 13.7% (21/153) and 46.4% (71/153), respectively. In total, 98.9% (89/90) serrated adenomas were found with dysplasia. Moreover, 14 patients with serrated polyps were found with synchronous advanced colorectal neoplasia, and large serrated polyps (LSPs) (odds ratio: 3.446, 95% confidence interval: 1.010-11.750, P < 0.05), especially large HPs, might have an association with synchronous advanced neoplasia (AN).
  
  
  CONCLUSIONS
  The overall detection rate of colorectal serrated polyps in Chinese symptomatic patient population was low, and distribution pattern of three subtypes is different from previous reports. Moreover, LSPs, especially large HPs, might be associated with an increased risk of synchronous AN.
authors.affiliation: Department of Gastroenterology and Hepatology, Tianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Hai-Long
authors.initials: HL
authors.lastname: Cao
authors.affiliation: Department of Gastroenterology and Hepatology, Tianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology and Hepatology, Tianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Shao-Chun
authors.initials: SC
authors.lastname: Du
authors.affiliation: Department of Pathology, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Wen-Jing
authors.initials: WJ
authors.lastname: Song
authors.affiliation: Department of Gastroenterology and Hepatology, Tianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Wei-Qiang
authors.initials: WQ
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology and Hepatology, Tianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Meng-Que
authors.initials: MQ
authors.lastname: Xu
authors.affiliation: Department of Gastroenterology and Hepatology, Tianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Si-Nan
authors.initials: SN
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology and Hepatology, Tianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Mei-Yu
authors.initials: MY
authors.lastname: Piao
authors.affiliation: Department of Gastroenterology and Hepatology, Tianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Xiao-Cang
authors.initials: XC
authors.lastname: Cao
authors.affiliation: Department of Gastroenterology and Hepatology, Tianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Bang-Mao
authors.initials: BM
authors.lastname: Wang
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D016009:Chi-Square Distribution; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000453:epidemiology*; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015995:Prevalence