title: Leucanone A and naamine J, glycerol ether lipid and imidazole alkaloid from the marine sponge Leucandra sp.
abstract: Chemical investigation on CH2Cl2extract of the marine sponge Leucandra sp. afforded two new compounds named leucanone A (1) and naamine J (2), together with eight known compounds (3-10). Their structures were elucidated on the basis of NMR spectroscopic analyses, and comparing with the literature. The cytotoxic activities of the compounds were evaluated against four cancer cell lines, and compound 2 showed mild cytotoxic activities against MCF-7, A549, HeLa, and PC9 cancer cell lines with IC50values in the range of 20.1-45.3 μM.
authors.affiliation: a Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy , Renji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai 200127 , China.
authors.forename: Wei-Zhuo
authors.initials: WZ
authors.lastname: Tang
authors.affiliation: a Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy , Renji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai 200127 , China.|b School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Zhong-Zhen
authors.initials: ZZ
authors.lastname: Yang
authors.affiliation: a Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy , Renji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai 200127 , China.
authors.forename: Fan
authors.initials: F
authors.lastname: Sun
authors.affiliation: a Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy , Renji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai 200127 , China.
authors.forename: Shu-Ping
authors.initials: SP
authors.lastname: Wang
authors.affiliation: a Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy , Renji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai 200127 , China.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.affiliation: a Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy , Renji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai 200127 , China.
authors.forename: Hou-Wen
authors.initials: HW
authors.lastname: Lin
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005995:Glyceryl Ethers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D007093:Imidazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008055:Lipids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D061986:MCF-7 Cells; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D005995:Glyceryl Ethers; D007093:Imidazoles; D008055:Lipids; C000621763:leucanone A; C000621764:naamine J
keywords: Imidazole alkaloid; Leucandra sp.; glycerol ether lipid