title: Loss of niche-satellite cell interactions in syndecan-3 null mice alters muscle progenitor cell homeostasis improving muscle regeneration.
abstract: The skeletal muscle stem cell niche provides an environment that maintains quiescent satellite cells, required for skeletal muscle homeostasis and regeneration. Syndecan-3, a transmembrane proteoglycan expressed in satellite cells, supports communication with the niche, providing cell interactions and signals to maintain quiescent satellite cells.
  
  
  
  Syndecan-3 ablation unexpectedly improves regeneration in repeatedly injured muscle and in dystrophic mice, accompanied by the persistence of sublaminar and interstitial, proliferating myoblasts. Additionally, muscle aging is improved in syndecan-3 null mice. Since syndecan-3 null myofiber-associated satellite cells downregulate Pax7 and migrate away from the niche more readily than wild type cells, syxndecan-3 appears to regulate satellite cell homeostasis and satellite cell homing to the niche.
  
  
  
  Manipulating syndecan-3 provides a promising target for development of therapies to enhance muscle regeneration in muscular dystrophies and in aged muscle.
authors.affiliation: Department of Cellular, Molecular and Developmental Biology, University of Colorado at Boulder, Boulder, CO 80309 USA ; Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool, L69 7ZB UK.
authors.forename: Addolorata
authors.initials: A
authors.lastname: Pisconti
authors.affiliation: Department of Neurology, University of Washington, Mail Stop 357720, Seattle, WA 98195 USA.
authors.forename: Glen B
authors.initials: GB
authors.lastname: Banks
authors.affiliation: The Biomedical Research Centre, UBC, Vancouver, BC V6T 1Z Canada.
authors.forename: Farshad
authors.initials: F
authors.lastname: Babaeijandaghi
authors.affiliation: Department of Cellular, Molecular and Developmental Biology, University of Colorado at Boulder, Boulder, CO 80309 USA.
authors.forename: Nicole Dalla
authors.initials: ND
authors.lastname: Betta
authors.affiliation: The Biomedical Research Centre, UBC, Vancouver, BC V6T 1Z Canada.
authors.forename: Fabio M V
authors.initials: FM
authors.lastname: Rossi
authors.affiliation: Department of Neurology, University of Washington, Mail Stop 357720, Seattle, WA 98195 USA.
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Chamberlain
authors.affiliation: Department of Cellular, Molecular and Developmental Biology, University of Colorado at Boulder, Boulder, CO 80309 USA.
authors.forename: Bradley B
authors.initials: BB
authors.lastname: Olwin
mesh_terms: D000818:Animals; D005260:Female; D006706:Homeostasis; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D018482:Muscle, Skeletal / Q000293:injuries / Q000473:pathology / Q000502:physiology*; D012038:Regeneration; D032496:Satellite Cells, Skeletal Muscle / Q000473:pathology / Q000502:physiology*; D055153:Stem Cell Niche; D053670:Syndecan-3 / Q000235:genetics / Q000502:physiology*
chemical_list: C508302:Sdc3 protein, mouse; D053670:Syndecan-3
keywords: Cell adhesion; Cell migration; Muscle regeneration; Muscular dystrophy; Niche; Pax7; Satellite cells; Syndecan-3