title: Efficient synthesis of D6-clenproperol and D6-cimaterol using deuterium isopropylamine as labelled precursor.
abstract: This report presents an efficient synthesis of D6-clenproperol and D6-cimaterol with 99.5% and 99.7% isotopic abundance in acceptable yields and excellent chemical purities with deuterium isopropylamine as labelled precursor. Their structures and the isotope-abundance were confirmed by proton nuclear magnetic resonance and liquid chromatography-mass spectrometry.
authors.affiliation: School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai, China.|Research and Development Center, Shanghai Research Institute of Chemical Industry, Shanghai, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Sun
authors.affiliation: Research and Development Center, Shanghai Research Institute of Chemical Industry, Shanghai, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Fang
authors.affiliation: Research and Development Center, Shanghai Research Institute of Chemical Industry, Shanghai, China.
authors.forename: Weicheng
authors.initials: W
authors.lastname: Yang
authors.affiliation: Research and Development Center, Shanghai Research Institute of Chemical Industry, Shanghai, China.
authors.forename: Zhongjie
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Research and Development Center, Shanghai Research Institute of Chemical Industry, Shanghai, China.
authors.forename: Haoran
authors.initials: H
authors.lastname: Wang
authors.affiliation: Research and Development Center, Shanghai Research Institute of Chemical Industry, Shanghai, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Sun
authors.affiliation: Research and Development Center, Shanghai Research Institute of Chemical Industry, Shanghai, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Luo
authors.affiliation: School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Xu
mesh_terms: D000318:Adrenergic beta-Agonists / Q000138:chemical synthesis / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic; D002976:Clenbuterol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D003903:Deuterium / Q000737:chemistry*; D004983:Ethanolamines / Q000138:chemical synthesis* / Q000737:chemistry*; D007553:Isotope Labeling; D011437:Propylamines / Q000737:chemistry*
chemical_list: D000318:Adrenergic beta-Agonists; D004983:Ethanolamines; D011437:Propylamines; C000624962:clenproperol; D003903:Deuterium; C035263:2-propylamine; D002976:Clenbuterol; C047411:cimaterol
keywords: D6-cimaterol; D6-clenproperol; deuterium isopropylamine; labelled internal standards; synthesis