title: Autonomic thermoregulatory dysfunction in neurofibromatosis type 1.
abstract: OBJECTIVE
  Neurofibromatosis type 1 (NF1) causes neural and cutaneous disorders and reduced exercise capacity. Exercise/heat exposure increasing internal temperature must be compensated by eccrine sweat function and warmed skin vasodilation. We suspected NF1 could adversely affect eccrine sweat function and/or vascular thermoregulatory responses (VTR).
  
  
  METHODS
  The eccrine sweat function and VTR of 25 NF1 volunteers (14 males, 11 females; 16-57 years old) were compared with 23 non-NF1 controls matched by sex, age, height and weight (CG). Sweating was induced by 1) pilocarpine 1% iontophoresis (PILO); and 2) by passive heating (HEAT) via the lower third of the legs being immersed in 42°C water for one hour. Previously established eccrine sweat function and VTR protocols were used.
  
  
  RESULTS
  The NF1 group showed: a) lower sweat rate than the CG group during PILO; b) a smaller diastolic pressure decrease; and c) higher tympanic temperatures than controls during HEAT (p < 0.05).
  
  
  CONCLUSIONS
  Reduced sweating and vascular thermoregulatory responses suggest autonomic dysfunction in NF1 individuals.
authors.affiliation: Universidade Federal de Minas Gerais, Escola de Educação Física, Fisioterapia e Terapia Ocupacional, Programa de Pós Graduação em Ciências do Esporte, Belo Horizonte MG, Brasil.
authors.forename: Luciana G
authors.initials: LG
authors.lastname: Madeira
authors.affiliation: Universidade Federal de Minas Gerais, Escola de Educação Física, Fisioterapia e Terapia Ocupacional, Programa de Pós Graduação em Ciências do Esporte, Belo Horizonte MG, Brasil.
authors.forename: Renata Lf
authors.initials: RL
authors.lastname: Passos
authors.affiliation: Universidade Federal de Minas Gerais, Hospital das Clínicas, Centro de Referência em Neurofibromatoses, Belo Horizonte MG, Brasil.
authors.forename: Juliana F de
authors.initials: JF
authors.lastname: Souza
authors.affiliation: Universidade Federal de Minas Gerais, Hospital das Clínicas, Centro de Referência em Neurofibromatoses, Belo Horizonte MG, Brasil.
authors.forename: Nilton A
authors.initials: NA
authors.lastname: Rezende
authors.affiliation: Universidade Federal de Minas Gerais, Escola de Educação Física, Fisioterapia e Terapia Ocupacional, Programa de Pós Graduação em Ciências do Esporte, Belo Horizonte MG, Brasil.|Universidade Federal de Minas Gerais, Hospital das Clínicas, Centro de Referência em Neurofibromatoses, Belo Horizonte MG, Brasil.
authors.forename: Luiz O C
authors.initials: LO
authors.lastname: Rodrigues
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D001833:Body Temperature Regulation / Q000502:physiology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009456:Neurofibromatosis 1 / Q000503:physiopathology*; D054969:Primary Dysautonomias / Q000503:physiopathology; D012016:Reference Values; D012737:Sex Factors; D012867:Skin / Q000503:physiopathology; D013542:Sweat / Q000502:physiology*; D013546:Sweating / Q000502:physiology; D013997:Time Factors; D055815:Young Adult