title: Diagnostic value of serum squamous cell carcinoma antigen for hepatocellular carcinoma: a systematic review and meta-analysis.
abstract: The aim of this study was to ascertain the diagnostic value of serum squamous cell carcinoma antigen (SCCA) and SCCA-IgM for hepatocellular carcinoma (HCC). After a comprehensive search of PubMed and Web of Science databases, we identified eligible studies on the diagnostic value serum SCCAs for HCC. The quality of the eligible studies was assessed using the revised Quality Assessment for Studies of Diagnostic Accuracy (QUADAS-2) tool. The overall diagnostic value of SCCAs for HCC was pooled using a bivariate model. Twelve studies were included in this systematic review and meta-analysis. The pooled sensitivities for SCCA and SCCA-IgM were 0.61 (95% confidence interval [CI], 0.37-0.81) and 0.70 (95% CI, 0.55-0.82), respectively. The corresponding specificities were 0.80 (95% CI, 0.52-0.94) and 0.62 (95% CI, 0.51-0.72), respectively. The areas under summary receiver operating characteristic (sROC) curves for SCCA and SCCA-IgM were 0.76 (95% CI, 0.72-0.80) and 0.70 (95% CI, 0.66-0.74), respectively. Major design deficiencies of the included studies were two-gate design and partial verification bias. Therefore, we concluded that both serum SCCA and SCCA-IgM have a fair diagnostic value for HCC.
authors.affiliation: a Department of Pathology, Shandong Medical College, Ji'nan, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yu
authors.affiliation: b Department of Physiology , Shandong Medical College , Ji'nan , P.R. China.
authors.forename: Zhao-Juan
authors.initials: ZJ
authors.lastname: Wang
authors.affiliation: c Department of Pharmacy , Shandong Medical College , Ji'nan , P.R. China.
authors.forename: Long-Hua
authors.initials: LH
authors.lastname: Chen
authors.affiliation: d Department of Gastroenterology , 401 Hospital of the Chinese People's Liberation Army , Qingdao , P.R. China.
authors.forename: Wen-Zhu
authors.initials: WZ
authors.lastname: Dong
mesh_terms: D000951:Antigens, Neoplasm / Q000097:blood*; D019540:Area Under Curve; D014408:Biomarkers, Tumor / Q000097:blood*; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D008113:Liver Neoplasms / Q000097:blood / Q000175:diagnosis*; D012372:ROC Curve; D015843:Serpins / Q000097:blood*
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D007075:Immunoglobulin M; D015843:Serpins; C051072:squamous cell carcinoma-related antigen
keywords: Diagnosis; hepatocellular carcinoma; meta-analysis; sensitivity; specificity; squamous cell carcinoma antigen