title: Catechin tuned magnetism of Gd-doped orthovanadate through morphology as T1-T2MRI contrast agents.
abstract: Tetragonal (t)-LaVO4has turned out to be a potential host for luminescent materials. Synthesis of t-LaVO4till date has been based on chelating effect of EDTA making it not ideal for bioimaging applications. An alternative was proposed by us through the use of catechin. In recent times there is interest for new MRI contrast agents that can through appropriate doping function both as MRI contrast and optical/upconversion materials. It is generally believed that under appropriate doping, t-LaVO4would be a better upconversion material than monoclinic (m)-LaVO4. Based on these postulations, this work explores the use of gadolinium doped t-LaVO4as an MRI contrast agent. From literature, gadolinium oxide is a good T1contrast agent. Through this work, using catechin as a template for the synthesis of Gd doped t-LaVO4, we demonstrate the possible use as a T1contrast agent. Interestingly, as the catechin concentration changes, morphology changes from nanorods to square nanoplates and spheres. In this process, a switch from T1to T2contrast agent was also observed. Under optimal concentration of catechin, with a rod shaped Gd doped t-LaVO4an r2/r1value of 21.30 was observed. Similarly, with a spherical shape had an r2/r1value of 1.48 was observed.
authors.affiliation: Chemical laboratory, CSIR-Central Leather Research Institute, Adyar, Chennai, 600 020, India.
authors.forename: Tamilmani
authors.initials: T
authors.lastname: Vairapperumal
authors.affiliation: Department of Physics, NSS College, Pandalam 689501, Kerala, India.
authors.forename: Ariya
authors.initials: A
authors.lastname: Saraswathy
authors.affiliation: Biophotonics and Imaging Lab, Sree Chitra Tirunal Institute for Medical Sciences and Technology, BMT Wing, Poojappura, Trivandrum 695012, India.
authors.forename: Jayasree S
authors.initials: JS
authors.lastname: Ramapurath
authors.affiliation: Chemical laboratory, CSIR-Central Leather Research Institute, Adyar, Chennai, 600 020, India.
authors.forename: Sreeram
authors.initials: S
authors.lastname: Kalarical Janardhanan
authors.affiliation: Chemical laboratory, CSIR-Central Leather Research Institute, Adyar, Chennai, 600 020, India.
authors.forename: Nair
authors.initials: N
authors.lastname: Balachandran Unni
mesh_terms: D002392:Catechin / Q000737:chemistry*; D003287:Contrast Media / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry*; D049449:Luminescence; D008279:Magnetic Resonance Imaging / Q000379:methods; D008280:Magnetics / Q000379:methods; D043942:Nanotubes / Q000737:chemistry; D014638:Vanadates / Q000737:chemistry*
chemical_list: D003287:Contrast Media; D014638:Vanadates; C030581:gadolinium oxide; D002392:Catechin; D005682:Gadolinium