title: Transforming growth factor-β1 in the cerebrospinal fluid of patients with distinct neurodegenerative diseases.
abstract: A chronic inflammatory condition may underlie neurodegenerative disorders, including Parkinson's disease (PD) and Alzheimer's disease (AD). For example, both PD and AD patients show an increase in transforming growth factor-β1 (TGF-β1) levels in their cerebrospinal fluid (CSF). TGF-β1 is a cytokine that inhibits inflammation. In the present study, using an enzyme-linked immunosorbent assay, we tested the hypothesis that the level of TGF-β1 in the CSF of patients with amyotrophic lateral sclerosis (ALS), spinocerebellar degeneration (SCD), or multiple system atrophy-cerebellar subtype (MSA-C) would be elevated compared with that of normal controls. We found that TGF-β1 levels in the CSF were not significantly different between these patients and normal controls. Our data suggest that the level of TGF-β1 in the CSF is an unreliable biomarker of ALS, SCD, and MSA-C.
authors.affiliation: Department of Neurobiology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8577, Japan; Department of Neurology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Masuda
authors.affiliation: Department of Neurology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Itoh
authors.affiliation: Department of Neurology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Koide
authors.affiliation: Department of Neurology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Tomidokoro
authors.affiliation: Department of Anatomy and Neuroscience, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8577, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Takei
authors.affiliation: Department of Neurology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan. Electronic address: kazishii@md.tsukuba.ac.jp.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ishii
authors.affiliation: Department of Neurology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Tamaoka
mesh_terms: D000328:Adult; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000175:diagnosis; D000690:Amyotrophic Lateral Sclerosis / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D015415:Biomarkers / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D019636:Neurodegenerative Diseases / Q000134:cerebrospinal fluid / Q000175:diagnosis; D010300:Parkinson Disease / Q000134:cerebrospinal fluid / Q000175:diagnosis; D020754:Spinocerebellar Ataxias / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D053773:Transforming Growth Factor beta1 / Q000134:cerebrospinal fluid*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D053773:Transforming Growth Factor beta1
keywords: Amyotrophic lateral sclerosis; Cerebrospinal fluid; Multiple system atrophy; Neurodegenerative disease; Spinocerebellar degeneration; Transforming growth factor-β1