title: T-cell lymphomas, a challenging disease: types, treatments, and future.
abstract: T-cell lymphomas are rare and aggressive malignancies associated with poor outcome, often because of the development of resistance in the lymphoma against chemotherapy as well as intolerance in patients to the established and toxic chemotherapy regimens. In this review article, we discuss the epidemiology, pathophysiology, current standard of care, and future treatments of common types of T-cell lymphomas, including adult T-cell leukemia/lymphoma, angioimmunoblastic T-cell lymphoma, anaplastic large-cell lymphoma, aggressive NK/T-cell lymphoma, and cutaneous T-cell lymphoma.
authors.affiliation: Department of Internal Medicine, New York University, New York, NY, USA.
authors.forename: Helen
authors.initials: H
authors.lastname: Ma
authors.affiliation: Department of Internal Medicine, New York University, New York, NY, USA. maher.abdulhay@nyumc.org.|Perlmutter Cancer Center, New York University, New York, NY, USA. maher.abdulhay@nyumc.org.
authors.forename: Maher
authors.identifier: http://orcid.org/0000-0003-1041-7689
authors.initials: M
authors.lastname: Abdul-Hay
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005047:Etoposide / Q000627:therapeutic use; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy*; D011241:Prednisone / Q000627:therapeutic use; D033581:Stem Cell Transplantation / Q000379:methods; D014184:Transplantation, Homologous; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone
keywords: Adult T-cell leukemia/lymphoma; Anaplastic large cell lymphoma; Angioimmunoblastic T-cell lymphoma; Cutaneous T-cell lymphoma; NK/T-cell lymphoma; Novel agents