title: ApoptomiRs of Breast Cancer: Basics to Clinics.
abstract: Apoptosis, a form of programmed cell death, is a highly regulated process, the deregulation of which has been associated with the tumor initiation, progression, and metastasis in various cancers including breast cancer. Induction of apoptosis is a popular target of various therapies currently being tested or used for breast cancer treatment. Thus, identifying apoptotic mediators and regulators is imperative for molecular biologists and clinicians for benefit of patients. The regulation of apoptosis is complex and involves a tight equilibrium between the pro- and anti-apoptotic factors. Recent studies have highlighted the role of miRNAs in the control of apoptosis and their interplay with p53, the master guardian of apoptosis. Here, we summarize and integrate the data on the role of miRNAs in apoptosis in breast cancer and the clinical advantage it may offer for the prognosis or treatment of breast cancer patients.
authors.affiliation: Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi New Delhi, India.
authors.forename: Shivani
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Department of Molecular Biology, Ariel University Ariel, Israel.
authors.forename: Praveen K
authors.initials: PK
authors.lastname: Patnaik
authors.affiliation: Department of Molecular Biology, Ariel University Ariel, Israel.
authors.forename: Stella
authors.initials: S
authors.lastname: Aronov
authors.affiliation: Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi New Delhi, India.
authors.forename: Ritu
authors.initials: R
authors.lastname: Kulshreshtha
keywords: apoptomiR; apoptosis; biomarker; breast cancer; microRNA