title: Dopamine/noradrenaline reuptake inhibition in women improves endurance exercise performance in the heat.
abstract: Catecholamine reuptake inhibition improves the performance of male volunteers exercising in warm conditions, but sex differences in thermoregulation, circulating hormones, and central neurotransmission may alter this response. With local ethics committee approval, nine physically active women (mean ± SD age 21 ± 2 years; height 1.68 ± 0.08 m; body mass 64.1 ± 6.0 kg; VO2peak51 ± 7 mL/kg/min) were recruited to examine the effect of pre-exercise administration of Bupropion (BUP; 4 × 150 mg) on prolonged exercise performance in a warm environment. Participants completed a VO2peaktest, two familiarization trials, and two randomized, double-blind experimental trials. All trials took place during the first 10 days of the follicular phase of the menstrual cycle. Participants cycled for 1 h at 60% VO2peakfollowed by a 30-min performance test. Total work done was greater during the BUP trial (291 ± 48 kJ) than the placebo trial (269 ± 46 kJ, P = 0.042, d = 0.497). At the end of the performance test, core temperature was higher on the BUP trial (39.5 ± 0.4 °C) than on the placebo trial (39.2 ± 0.6 °C, P = 0.021; d = 0.588), as was heart rate (185 ± 9 vs 179 ± 13, P = 0.043; d = 0.537). The results indicate that during the follicular phase of the menstrual cycle, an acute dosing protocol of BUP can improve self-regulated performance in warm conditions.
authors.affiliation: School of Sport, Exercise and Health Sciences, Loughborough University, Leicestershire, UK.
authors.forename: P
authors.initials: P
authors.lastname: Cordery
authors.affiliation: England and Wales Cricket Board, National Cricket Performance Centre, Loughborough University, Leicestershire, UK.
authors.forename: N
authors.initials: N
authors.lastname: Peirce
authors.affiliation: School of Sport, Exercise and Health Sciences, Loughborough University, Leicestershire, UK.
authors.forename: R J
authors.initials: RJ
authors.lastname: Maughan
authors.affiliation: Department of Human Physiology, Vrije Universiteit Brussel, Brussels, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Watson
mesh_terms: D054874:Athletic Performance; D016642:Bupropion / Q000008:administration & dosage*; D004298:Dopamine; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage*; D004311:Double-Blind Method; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D006339:Heart Rate; D006358:Hot Temperature; D006801:Humans; D009638:Norepinephrine; D010101:Oxygen Consumption; D010807:Physical Endurance / Q000502:physiology*; D055815:Young Adult
chemical_list: D018765:Dopamine Uptake Inhibitors; D016642:Bupropion; D004298:Dopamine; D009638:Norepinephrine
keywords: Bupropion; central fatigue; female thermoregulation; heat stress; performance