title: Effects of chronic sleep deprivation on glucose homeostasis in rats.
abstract: Epidemiological studies have shown that chronic sleep disturbances resulted in metabolic disorders. The purpose of this study was to assess the relationship between chronic sleep deprivation (CSD) and the glucose homeostasis in rats. Twenty-four rats were randomly divided into CSD group and control (CON) group. The CSD rats were intervened by a modified multiple platform method (MMPM) to establish an animal model of chronic sleep disturbances. After 3-month intervention, all rats were subjected to an intraperitoneal glucose tolerance test (IPGTT) and an insulin tolerance test (ITT), and the body weight, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, lipid profile group, and homeostasis model assessment-IR (HOMA-IR) were measured. Both the CSD and CON groups had an attenuation of weight gain after 3-month intervention. The plasma glucose level of CSD group was higher than that of the CON group during the IPGTT (P< 0.01). The CSD rats showed a marked increase in HOMA-IR and ITT compared with the CON group (P< 0.01). There were no significant differences of AST, ALT, creatinine, and most lipid parameters between the CSD and CON groups (P> 0.05). The CSD has a marked effect on glucose homeostasis, comprising glucose intolerance and insulin resistance.
authors.affiliation: Center of Orthopedics, The 309th Hospital of PLA, No. 17 Heishanhu Road, Haidian District, Beijing, 100091 China.
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Xu
authors.affiliation: Center of Orthopedics, The 309th Hospital of PLA, No. 17 Heishanhu Road, Haidian District, Beijing, 100091 China.
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.affiliation: Center for Systems Biomedical Sciences, University of Shanghai for Science and Technology, Shanghai, 200093 China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Center of Orthopedics, The 309th Hospital of PLA, No. 17 Heishanhu Road, Haidian District, Beijing, 100091 China.
authors.forename: Tianjiao
authors.initials: T
authors.lastname: Su
authors.affiliation: Center of Orthopedics, The 309th Hospital of PLA, No. 17 Heishanhu Road, Haidian District, Beijing, 100091 China.
authors.forename: Liying
authors.initials: L
authors.lastname: Chen
authors.affiliation: Center of Orthopedics, The 309th Hospital of PLA, No. 17 Heishanhu Road, Haidian District, Beijing, 100091 China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Center of Orthopedics, The 309th Hospital of PLA, No. 17 Heishanhu Road, Haidian District, Beijing, 100091 China.
authors.forename: Weifeng
authors.initials: W
authors.lastname: Ma
authors.affiliation: Center of Orthopedics, The 309th Hospital of PLA, No. 17 Heishanhu Road, Haidian District, Beijing, 100091 China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Center of Orthopedics, The 309th Hospital of PLA, No. 17 Heishanhu Road, Haidian District, Beijing, 100091 China.
authors.forename: Tiantian
authors.initials: T
authors.lastname: Wang
authors.affiliation: Center of Orthopedics, The 309th Hospital of PLA, No. 17 Heishanhu Road, Haidian District, Beijing, 100091 China.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.affiliation: Director of Division of Science and Technology, National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing, 100050 China.
authors.forename: Li
authors.initials: L
authors.lastname: He
authors.affiliation: Center of Orthopedics, The 309th Hospital of PLA, No. 17 Heishanhu Road, Haidian District, Beijing, 100091 China.
authors.forename: Wenjiao
authors.initials: W
authors.lastname: Wang
authors.affiliation: Center of Orthopedics, The 309th Hospital of PLA, No. 17 Heishanhu Road, Haidian District, Beijing, 100091 China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Fu
authors.affiliation: Center of Health Care, The 309th Hospital of PLA, No. 17 Heishanhu Road, Haidian District, Beijing, 100091 China.
authors.forename: Hongxia
authors.initials: H
authors.lastname: Hao
authors.affiliation: Center of Orthopedics, The 309th Hospital of PLA, No. 17 Heishanhu Road, Haidian District, Beijing, 100091 China.
authors.forename: Yuanzheng
authors.initials: Y
authors.lastname: Ma
keywords: Body weight; Chronic sleep deprivation; Glucose intolerance; Insulin resistance