title: 123I-FP-CIT and 99mTc-HMPAO in Pathologically Confirmed Progressive Supranuclear Palsy.
abstract: Molecular brain imaging I-FP-CIT SPECT is an important tool in evaluation of patients with parkinsonism. However, various neurodegenerative etiologies cannot be differentiated by I-FP-CIT SPECT alone. We present a case of progressive supranuclear palsy with abnormal I-FP-CIT SPECT and abnormal Tc-HMPAO SPECT depicted by quantitative analyses but unremarkable MRI 16 months after the onset of symptoms. Brain autopsy demonstrated presence of neuronal and glial tau pathology in both cortical and subcortical regions confirming the diagnosis of progressive supranuclear palsy. This case illustrates potential values of multimodal molecular brain imaging in conjunction with quantitative analysis in the evaluation of movement disorders.
authors.affiliation: From the *Department of Radiology, University of Washington, Seattle, WA; †Department of Radiology, University of New Mexico, Albuquerque, NM; and ‡Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT.
authors.forename: Manuela Cristina
authors.initials: MC
authors.lastname: Matesan
authors.forename: Saeed
authors.initials: S
authors.lastname: Elojeimy
authors.forename: Satoshi
authors.initials: S
authors.lastname: Minoshima
mesh_terms: D005260:Female; D006801:Humans; D008875:Middle Aged; D019275:Radiopharmaceuticals; D013494:Supranuclear Palsy, Progressive / Q000000981:diagnostic imaging*; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon; D014326:Tropanes
chemical_list: D019275:Radiopharmaceuticals; D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane; D019690:Technetium Tc 99m Exametazime