title: One-month apparent diffusion coefficient correlates with response to radiofrequency ablation of hepatocellular carcinoma.
abstract: To assess whether apparent diffusion coefficient (ADC) values at 1 and 3 months after radiofrequency ablation (RFA) may be associated with a favorable response to therapy for hepatocellular carcinoma (HCC) and liver metastases.
  
  
  
  Fifty-nine patients with HCC (n = 35) or liver metastases (n = 24) who underwent 1.5T diffusion-weighted magnetic resonance imaging (DWMRI) at 1 and 3 months post-RFA were included. ADC values of patients with local tumor recurrence were compared to those without local recurrence. A subgroup analysis was performed for HCC and metastases.
  
  
  
  Thirty-eight HCC and 27 metastases were evaluated. The ADC value of HCC at 1 month after RFA was lower in recurrent tumors (0.957 ± 0.229 [SD] × 10-3mm2) compared to tumors with complete response (1.414 ± 0.322 [SD] × 10-3mm2/s, P = 0.006). At multivariate analysis, ADC at 1 month was the single independent variable associated with recurrence for HCC (area under the receiver operating characteristic curve = 0.860). No significant association was observed for liver metastases (P = 0.089).
  
  
  
  A low ADC value at 1 month after RFA is associated with an early local recurrence of HCC. This study does not confirm that such association exists for hepatic metastases.
  
  
  
  3 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;45:1648-1658.
authors.affiliation: Department of Body and Interventional Imaging, Hôpital Lariboisière, Paris, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Barat
authors.affiliation: CNRS, UMR 6301-ISTCT, CERVOxy, GIP CYCERON, Caen, France.|CEA, DSV/I2BM, UMR6301-ISTCT, Caen, France.|Normandie Université, France.|UNICAEN, UMR6301-ISTCT, Caen, France.|CHU de CAEN, Service d'Imagerie Diagnostique et de Radiologie Thérapeutique, Caen, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Fohlen
authors.affiliation: Department of Diagnostic and Interventional Imaging, Hôpîtal Haut-Lévêque, Centre Hospitalier Universitaire de Bordeaux, Pessac, France.|INSERM U1053, Université Bordeaux, Bordeaux, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Cassinotto
authors.affiliation: INSERM-UMRS 1138 Team 22, Cordeliers Research Center, Paris, France.|Paris Descartes University, Paris, France.|Department of Medical Informatics and Public Health, European George Pompidou Hospital, Paris, France.
authors.forename: Anne Sophie
authors.initials: AS
authors.lastname: Jannot
authors.affiliation: Department of Body and Interventional Imaging, Hôpital Lariboisière, Paris, France.
authors.forename: Raphael
authors.initials: R
authors.lastname: Dautry
authors.affiliation: CNRS, UMR 6301-ISTCT, CERVOxy, GIP CYCERON, Caen, France.|CEA, DSV/I2BM, UMR6301-ISTCT, Caen, France.|Normandie Université, France.|UNICAEN, UMR6301-ISTCT, Caen, France.|CHU de CAEN, Service d'Imagerie Diagnostique et de Radiologie Thérapeutique, Caen, France.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Pelage
authors.affiliation: Department of Body and Interventional Imaging, Hôpital Lariboisière, Paris, France.
authors.forename: Mourad
authors.initials: M
authors.lastname: Boudiaf
authors.affiliation: Université Paris-Diderot, Sorbonne-Paris Cité, Paris, France.|UMR CART - INSERM 965, Hôpital Lariboisière, Paris, France.|Department of Digestive Surgery, Hôpital Lariboisière, Paris, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Pocard
authors.affiliation: Université Paris-Diderot, Sorbonne-Paris Cité, Paris, France.|UMR CART - INSERM 965, Hôpital Lariboisière, Paris, France.|Department of Digestive Surgery, Hôpital Lariboisière, Paris, France.
authors.forename: Clarisse
authors.initials: C
authors.lastname: Eveno
authors.affiliation: Department of Radiology and Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Bachir
authors.initials: B
authors.lastname: Taouli
authors.affiliation: Department of Body and Interventional Imaging, Hôpital Lariboisière, Paris, France.|Université Paris-Diderot, Sorbonne-Paris Cité, Paris, France.|UMR CART - INSERM 965, Hôpital Lariboisière, Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Soyer
authors.affiliation: Department of Body and Interventional Imaging, Hôpital Lariboisière, Paris, France.|Université Paris-Diderot, Sorbonne-Paris Cité, Paris, France.|UMR CART - INSERM 965, Hôpital Lariboisière, Paris, France.|McGill University Health Center, Department of Radiology, McGill University Health Center, Montreal, QC, Canada.
authors.forename: Anthony
authors.initials: A
authors.lastname: Dohan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D017115:Catheter Ablation / Q000379:methods*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging / Q000517:prevention & control*; D011379:Prognosis; D012189:Retrospective Studies; D013223:Statistics as Topic; D016896:Treatment Outcome
keywords: diffusion-weighted MRI; hepatocellular carcinoma; liver metastases; radiofrequency ablation