title: Access to 2-Arylindoles via Decarboxylative C-C Coupling in Aqueous Medium and to Heteroaryl Carboxylates under Base-Free Conditions using Diaryliodonium Salts.
abstract: Easily accessible heteroaromatic carboxylic acids and diaryliodonium salts were successfully employed to construct valuable 2-arylindoles and heteroaryl carboxylates in a regioselective fashion. C2-arylated indoles were produced using a Pd-catalyzed decarboxylative strategy in water without any base, oxidant, or ligand. Heteroaryl carboxylates were prepared under metal and base-free conditions. This protocol was successfully utilized to synthesize Paullone, a cyclin-dependent kinase (CDK) inhibitor.
authors.affiliation: Department of Chemistry, Birla Institute of Technology and Science, Pilani-, 333031, Rajasthan, India.
authors.forename: Velladurai
authors.initials: V
authors.lastname: Arun
authors.affiliation: Department of Chemistry, Birla Institute of Technology and Science, Pilani-, 333031, Rajasthan, India.
authors.forename: Meenakshi
authors.initials: M
authors.lastname: Pilania
authors.affiliation: Department of Chemistry, Birla Institute of Technology and Science, Pilani-, 333031, Rajasthan, India.
authors.forename: Dalip
authors.initials: D
authors.lastname: Kumar
keywords: C−C coupling; arylation; diaryliodonium salt; heterocycles; homogeneous catalysis