title: Thrombotic Microangiopathy Syndrome in a Basic Underwater Demolition/SEAL Student.
abstract: Thrombotic microangiopathy (TMA) syndromes represent a spectrum of illnesses that share common clinical and pathologic features of microangiopathic hemolytic anemia, thrombocytopenia, and organ injury from pathologic small-vessel thrombosis. At least nine primary TMA syndromes have been described and classified based on common probable etiologies, diagnostic criteria, and treatments. The most recognized of the TMA syndromes include thrombotic thrombocytopenic purpura (TTP) and hemolytic-uremic syndrome (HUS). Advanced laboratory techniques are required to distinguish between these syndromes; however, all patients should initially be treated with plasma exchange for presumed ADAMTS13 deficiency-mediated TMA. The authors present a case of a TMA syndrome in a Navy SEAL (Sea, Air, Land) candidate.
authors.forename: Daniel
authors.initials: D
authors.lastname: Croom
authors.forename: Heather
authors.initials: H
authors.lastname: Tracy
mesh_terms: D000071120:ADAMTS13 Protein / Q000097:blood; D006801:Humans; D008297:Male; D008889:Military Personnel; D010951:Plasma Exchange; D013577:Syndrome; D057049:Thrombotic Microangiopathies / Q000175:diagnosis* / Q000201:enzymology / Q000628:therapy; D055815:Young Adult
chemical_list: D000071120:ADAMTS13 Protein; C099604:ADAMTS13 protein, human