title: Comparison of absorbed irrigation fluid volumes during retrograde intrarenal surgery and percutaneous nephrolithotomy for the treatment of kidney stones larger than 2 cm.
abstract: OBJECTIVE
  Irrigation-induced increase in intrarenal pressure is of concern because it may cause infection due to increased pyelovenous and pyelolymphatic absorption. This study is the first to compare prospectively the absorbed fluid volumes during percutaneous nephrolithotomy (PCNL) and retrograde intrarenal surgery (RIRS) for stones larger than 2 cm.
  
  
  METHODS
  General anesthesia was applied to all patients. Isotonic solution containing 1 % ethanol was used as irrigation fluid. Venous blood ethanol concentration was first measured with the start of irrigation and thereafter every 15 min until the patients left the recovery room. Absorbed fluid volumes were measured using the blood ethanol concentrations. Duration of irrigation, irrigated fluid volume, stone size and grade of hydronephrosis were also recorded.
  
  
  RESULTS
  A total of 60 patients were included the study. Fluid absorption occurred in all patients. Minimum and maximum ranges of fluid absorption were 20-573 mL for RIRS and 13-364 mL for PCNL. The increase in fluid absorbed volume was observed as a result of the given amount of irrigating fluid used in the PCNL group. Also prolongation of operation led to a significant increase in absorption in the PCNL group. Increase in body mass index, stone size, and hydronephrosis did not affect fluid absorption significantly in either of the two operation techniques in correlation analyzes.
  
  
  CONCLUSIONS
  Both RIRS and PCNL are conducted under high pressure and can be accompanied potential complications such as SIRS. The fluid absorption confirmed in our study should be taken into consideration during RIRS and PCNL.
authors.affiliation: Department of Urology, School of Medicine, Medical Faculty of Medipol University, TEM Avrupa Otoyolu Goztepe Cikisi No: 1 Bagcilar, 34214 Istanbul, Turkey.
authors.forename: Vahit
authors.identifier: 0000-0001-9988-2944
authors.initials: V
authors.lastname: Guzelburc
authors.affiliation: Department of Urology, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Balasar
authors.affiliation: Biochemistry Department, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
authors.forename: Mukaddes
authors.initials: M
authors.lastname: Colakogullari
authors.affiliation: Department of Urology, School of Medicine, Medical Faculty of Medipol University, TEM Avrupa Otoyolu Goztepe Cikisi No: 1 Bagcilar, 34214 Istanbul, Turkey.
authors.forename: Selcuk
authors.initials: S
authors.lastname: Guven
authors.affiliation: Department of Urology, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey.
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Kandemir
authors.affiliation: Department of Urology, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ozturk
authors.affiliation: Biochemistry Department, School of Medicine, Istanbul Medipol University, Istanbul, Turkey ; Department of Anesthesiology, School of Medicine, Medipol University, Istanbul, Turkey.
authors.forename: Pelin
authors.initials: P
authors.lastname: Karaaslan
authors.affiliation: Department of Urology, School of Medicine, Medical Faculty of Medipol University, TEM Avrupa Otoyolu Goztepe Cikisi No: 1 Bagcilar, 34214 Istanbul, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Erkurt
authors.affiliation: Department of Urology, School of Medicine, Medical Faculty of Medipol University, TEM Avrupa Otoyolu Goztepe Cikisi No: 1 Bagcilar, 34214 Istanbul, Turkey.
authors.forename: Selami
authors.initials: S
authors.lastname: Albayrak
keywords: Complication; Flexible ureteroscopy; Percutaneous nephrolithotomy; Renal stone; Retrograde intrarenal surgery