title: Spinal Metastases of Extramammary Paget Disease with Radiologic-Pathologic Correlation.
abstract: Extramammary Paget disease (EMPD) is an uncommon malignancy. It manifests either in the primary form in the skin as an intraepithelial neoplasm, or in secondary form as pagetoid (intraepithelial) spread of an underlying internal carcinoma to the skin. Although local invasion and recurrence of primary extramammary Paget disease are relatively frequent, widespread metastases are rare. As such, there are very few reports and little characterization of the radiologic features of widespread spinal metastases. To our knowledge, there are no prior reports of a metastatic extramammary Paget disease presenting as a painful pathologic vertebral body compression fracture. We report the radiological features of a case of primary extramammary Paget disease with subsequent spinal metastases presenting as a painful compression fracture.
authors.affiliation: Department of Radiology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Jason T
authors.initials: JT
authors.lastname: Little
authors.affiliation: Department of Radiology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Vance T
authors.initials: VT
authors.lastname: Lehman
authors.affiliation: Department of Radiology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Morris
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Julia S
authors.initials: JS
authors.lastname: Lehman
authors.affiliation: Department of Radiology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Felix E
authors.initials: FE
authors.lastname: Diehn
mesh_terms: D001706:Biopsy; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D050815:Fractures, Compression / Q000000981:diagnostic imaging* / Q000209:etiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010145:Paget Disease, Extramammary / Q000473:pathology*; D000072078:Positron Emission Tomography Computed Tomography; D012878:Skin Neoplasms / Q000473:pathology*; D016103:Spinal Fractures / Q000000981:diagnostic imaging* / Q000209:etiology*; D013125:Spinal Neoplasms / Q000556:secondary*
keywords: Extramammary Paget disease; spinal metastases; spine MRI