title: Intraoperative floppy iris syndrome and its association with various concurrent medications, bulbus length, patient age and gender.
abstract: OBJECTIVE
  To evaluate the association between intraoperative floppy iris syndrome (IFIS) and concurrent medications containing selective alpha1A receptor antagonists as well as nonselective alpha1-adrenergic receptor antagonists, bulbus length, patient age and gender.
  
  
  METHODS
  We performed a prospective data acquisition of IFIS occurrence and grading, and retrospective evaluation of concurrent medications, bulbus length, patient age and gender of all patients undergoing cataract surgery over a 6-month period.
  
  
  RESULTS
  IFIS was observed in 119 of 947 cases (12.6 %). 31 of those 119 patients (26.1 %) had a concurrent medication with a drug that is associated with a higher risk of causing IFIS. Tamsulosin was the drug most commonly associated with IFIS (n = 11), followed by a combination of drugs (n = 7), doxazosin (n = 4), quetiapine (n = 4), finasterid (n = 2), prothipendyl (n = 2), and mianserin (n = 1). Bulbus length and age did not show any significant association with occurrence or grade of IFIS. Gender distribution among IFIS cases was 57.1 % males (n = 68) and 42.9 % (n = 51) females.
  
  
  CONCLUSIONS
  The occurrence of IFIS has to be expected with a variety of concurrent medications. The number of IFIS cases and the percentage of females in this series are higher compared to previous reports. The observations might be due to a rising awareness of surgeons or to an increasing number of causative medications on the market.
authors.affiliation: Department of Ophthalmology, Hietzing Hospital, Wolkersbergenstrasse 1, 1130, Vienna, Austria.|Karl Landsteiner Institute for Process Optimization and Quality Management in Cataract Surgery, Hietzing Hospital, Wolkersbergenstrasse 1, 1130, Vienna, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Wahl
authors.affiliation: Department of Ophthalmology, Hietzing Hospital, Wolkersbergenstrasse 1, 1130, Vienna, Austria.|Karl Landsteiner Institute for Process Optimization and Quality Management in Cataract Surgery, Hietzing Hospital, Wolkersbergenstrasse 1, 1130, Vienna, Austria.
authors.forename: Saskia M
authors.initials: SM
authors.lastname: Tipotsch-Maca
authors.affiliation: Department of Ophthalmology, Hietzing Hospital, Wolkersbergenstrasse 1, 1130, Vienna, Austria. saskia_tipotsch@yahoo.com.|Karl Landsteiner Institute for Process Optimization and Quality Management in Cataract Surgery, Hietzing Hospital, Wolkersbergenstrasse 1, 1130, Vienna, Austria. saskia_tipotsch@yahoo.com.
authors.forename: Pia V
authors.initials: PV
authors.lastname: Vecsei-Marlovits
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000009:adverse effects*; D000367:Age Factors; D000368:Aged; D001317:Austria / Q000453:epidemiology; D002387:Cataract Extraction / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007431:Intraoperative Complications; D007498:Iris / Q000187:drug effects* / Q000473:pathology; D007499:Iris Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D009830:Olfactory Bulb / Q000000981:diagnostic imaging*; D011446:Prospective Studies; D012307:Risk Factors; D013577:Syndrome; D013997:Time Factors
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists
keywords: Bulbus length; Cataract surgery; Gender; Intraoperative floppy iris syndrome; Medication