title: Assessment of the link between endothelin K198n Snp, endothelin concentration and acute myocardial infarction in Egyptians.
abstract: The aim of the current study was to assess the link between EDN K198N SNP, ET-1 serum concentration and acute myocardial infarction (AMI) in Egyptians. The study cohort consisted of 84 patients at AMI onset and 84 age-matched healthy controls. Endothelin genotypes and concentrations were determined by sequencing and ELISA, respectively. Genotype distribution was not significantly different between AMI patients and controls (P=.8341). The mean serum ET-1 concentration of patients (13.83±0.7 pg/mL) was significantly higher than controls (7.26±0.2 pg/mL) (P<.0001). ET-1 serum concentrations did not vary significantly among various EDN genotypes in patients (P=.378) and controls (P=.6164). Hence, we conclude that EDN K198N genotypes were not related to either ET-1 concentration or incidence of early-onset AMI in Egyptians. But, AMI patients had higher ET-1 concentrations than controls.
authors.affiliation: Biochemistry Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Cairo, Egypt.
authors.forename: Mohamed F
authors.initials: MF
authors.lastname: Abdel Rahman
authors.affiliation: Clinical Biochemistry Unit, Faculty of Pharmacy & Biotechnology, German University in Cairo, Cairo, Egypt.
authors.forename: Ingy M
authors.initials: IM
authors.lastname: Hashad
authors.affiliation: Clinical Biochemistry Unit, Faculty of Pharmacy & Biotechnology, German University in Cairo, Cairo, Egypt.
authors.forename: Khaled
authors.initials: K
authors.lastname: Abou-Aisha
authors.affiliation: Clinical Biochemistry Unit, Faculty of Pharmacy & Biotechnology, German University in Cairo, Cairo, Egypt.
authors.forename: Sahar M
authors.initials: SM
authors.lastname: Abdel Maksoud
authors.affiliation: Clinical Biochemistry Unit, Faculty of Pharmacy & Biotechnology, German University in Cairo, Cairo, Egypt.
authors.forename: Mohamed Z
authors.initials: MZ
authors.lastname: Gad
mesh_terms: D000328:Adult; D004534:Egypt / Q000453:epidemiology; D019332:Endothelin-1 / Q000097:blood* / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D019332:Endothelin-1
keywords: 
  acute myocardial infarction
  ; Egyptian; endothelin; polymorphism