title: Complete Recovery After Acute Zonisamide Overdose in an Adolescent Female.
abstract: Zonisamide is a sulfonamide drug used primarily for the treatment of partial seizures in adults. We describe the case of a 15-year-old woman with a mood disorder who survived without complications after ingestion of an estimated 7.5 g of zonisamide. To the best of our knowledge, there are 4 case reports of individuals with intentional ingestion of more than 4 g of zonisamide as a single agent. Our patient developed coma and hypotension 4 hours after ingestion and was treated with a catecholamine infusion, endotracheal intubation, and mechanical ventilation. She had mild electrocardiographic abnormalities and fully recovered after 4 days. This report contributes to the understanding of acute zonisamide poisoning.
authors.forename: Charlayne
authors.initials: C
authors.lastname: McStay
authors.forename: Richard
authors.initials: R
authors.lastname: Pierce
authors.forename: Carley
authors.initials: C
authors.lastname: Riley
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000506:poisoning*; D002395:Catecholamines / Q000627:therapeutic use; D062787:Drug Overdose / Q000628:therapy*; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal / Q000379:methods; D007555:Isoxazoles / Q000506:poisoning*; D019964:Mood Disorders / Q000188:drug therapy; D012121:Respiration, Artificial / Q000379:methods; D013406:Suicide, Attempted; D000078305:Zonisamide
chemical_list: D000927:Anticonvulsants; D002395:Catecholamines; D007555:Isoxazoles; D000078305:Zonisamide