title: The Efficacy of Postoperative Cyclic Oral Contraceptives after Gonadotropin-Releasing Hormone Agonist Therapy to Prevent Endometrioma Recurrence in Adolescents.
abstract: OBJECTIVE
  Young age is a possible risk factor of endometriosis recurrence after surgery. However, the efficacy of postoperative medical treatment has not been well addressed in adolescents. The purpose of this study was to evaluate whether postoperative medical treatment is as effective in adolescents as it is in adults in the prevention of endometrioma recurrence.
  
  
  METHODS
  A retrospective cohort study.
  
  
  METHODS
  Samsung Medical Center, Seoul, Korea.
  
  
  METHODS
  This study included 176 reproductive-aged women who underwent conservative laparoscopic surgery for pathology-confirmed endometrioma. Women were classified into 2 groups according to age: adolescents (20 years of age and younger, n = 34; group I) and reproductive-aged women (aged 25-35 years, n = 142; group II).
  
  
  METHODS
  The same surgeon performed all of the surgeries for uniformity. Postoperatively, patients were treated monthly with a gonadotropin-releasing hormone agonist depot for 3-6 months, followed by cyclic oral contraceptives.
  
  
  METHODS
  Endometrioma recurrence was determined using ultrasonography. The recurrence rate of endometrioma was compared between the 2 groups.
  
  
  RESULTS
  During the treatment period (median, 41.0 months; range, 6-159 months), recurrence was noted in 8 cases (4.5%). After adjusting for confounders (which were statistically different between the groups), the cumulative proportion of recurrent endometriomas after 60 months was comparable between the 2 groups (5.3% in group I and 8.5% in group II).
  
  
  CONCLUSIONS
  Long-term postoperative medical treatment with cyclic oral contraceptives after a gonadotropin-releasing hormone agonist can be as effective in adolescents as it is in adults in the prevention of endometrioma recurrence.
authors.affiliation: Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Jong-Wook
authors.initials: JW
authors.lastname: Seo
authors.affiliation: Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Dong-Yun
authors.initials: DY
authors.lastname: Lee
authors.affiliation: Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Byung-Koo
authors.initials: BK
authors.lastname: Yoon
authors.affiliation: Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. Electronic address: dooseok.choi@samsung.com.
authors.forename: DooSeok
authors.initials: D
authors.lastname: Choi
mesh_terms: D000293:Adolescent; D000328:Adult; D003131:Combined Modality Therapy; D003276:Contraceptives, Oral / Q000008:administration & dosage*; D004715:Endometriosis / Q000188:drug therapy / Q000517:prevention & control* / Q000601:surgery; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D010535:Laparoscopy; D011183:Postoperative Complications / Q000188:drug therapy / Q000517:prevention & control*; D012008:Recurrence; D056910:Republic of Korea; D012189:Retrospective Studies; D055502:Secondary Prevention / Q000379:methods*; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D003276:Contraceptives, Oral; D007987:Gonadotropin-Releasing Hormone
keywords: Adolescent; Endometrioma recurrence; Postoperative medical treatment