title: Central corneal thickness and its relationship to ocular parameters in young adult myopic eyes.
abstract: BACKGROUND
  An investigation was carried out to find the distribution of central corneal thickness (CCT) and the association between CCT and ocular factors in a cohort of myopic Chinese adults who underwent laser refractive surgery.
  
  
  METHODS
  Medical records of 1,190 subjects (754 males) aged from 18 to 44 years (21.5 ± 3.5 years for males and 24.9 ± 5.5 years for females) undergoing myopic refractive surgery were filtered and analysed. Each parameter was stratified by gender and eye, respectively. Multi-linear and linear regressions were used to analyse the effect of intraocular pressure (IOP), period of contact lens wearing, gender, age, refractive error, mean corneal curvature (K) and ocular high-order aberration at 5.0-mm zone on CCT.
  
  
  RESULTS
  The mean CCT was 539.2 ± 37.8 µm in the whole study population. Males had greater CCT than females (p < 0.001), while females had greater K than males (p < 0.001). There was no difference in IOP, ocular cylinder or higher-order aberrations between genders. No interocular difference was identified either in IOP or K. Multi-linear regression model revealed that only gender, IOP and K were correlated with CCT (standardised coefficients of right eye are -0.101, p = 0.001 for gender, 0.231, p < 0.001 for IOP and -0.080, p = 0.009 for K; standardised coefficients of left eye are -0.090, p = 0.002 for gender, 0.310, p < 0.001 for IOP and -0.076, p = 0.015 for K).
  
  
  CONCLUSIONS
  In a population of myopic candidates for laser refractive surgery, only gender, IOP and K were correlated with CCT.
authors.affiliation: Department of Ophthalmology, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Ophthalmology, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
authors.forename: Wenwen
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Epidemiology and Health Statistics, Medical College of Qingdao University, Qingdao, Shandong, China.
authors.forename: Yili
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Ophthalmology, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Ophthalmology, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
authors.forename: Guiqiu
authors.initials: G
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D003315:Cornea / Q000473:pathology* / Q000601:surgery; D019781:Corneal Topography / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009216:Myopia / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D011184:Postoperative Period; D012029:Refraction, Ocular; D054140:Refractive Surgical Procedures; D012189:Retrospective Studies; D055815:Young Adult
keywords: contact lenses; corneal topography; intraocular pressure; myopia