title: Synthetic quantitative MRI through relaxometry modelling.
abstract: Quantitative MRI (qMRI) provides standardized measures of specific physical parameters that are sensitive to the underlying tissue microstructure and are a first step towards achieving maps of biologically relevant metrics through in vivo histology using MRI. Recently proposed models have described the interdependence of qMRI parameters. Combining such models with the concept of image synthesis points towards a novel approach to synthetic qMRI, in which maps of fundamentally different physical properties are constructed through the use of biophysical models. In this study, the utility of synthetic qMRI is investigated within the context of a recently proposed linear relaxometry model. Two neuroimaging applications are considered. In the first, artefact-free quantitative maps are synthesized from motion-corrupted data by exploiting the over-determined nature of the relaxometry model and the fact that the artefact is inconsistent across the data. In the second application, a map of magnetization transfer (MT) saturation is synthesized without the need to acquire an MT-weighted volume, which directly leads to a reduction in the specific absorption rate of the acquisition. This feature would be particularly important for ultra-high field applications. The synthetic MT map is shown to provide improved segmentation of deep grey matter structures, relative to segmentation using T1-weighted images or R1maps. The proposed approach of synthetic qMRI shows promise for maximizing the extraction of high quality information related to tissue microstructure from qMRI protocols and furthering our understanding of the interrelation of these qMRI parameters.
authors.affiliation: Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, University College London, London, UK.
authors.forename: Martina F
authors.initials: MF
authors.lastname: Callaghan
authors.affiliation: Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, University College London, London, UK.|Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: Siawoosh
authors.initials: S
authors.lastname: Mohammadi
authors.affiliation: Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, University College London, London, UK.|Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Weiskopf
mesh_terms: D000293:Adolescent; D000328:Adult; D000465:Algorithms; D016477:Artifacts; D001921:Brain / Q000033:anatomy & histology*; D003198:Computer Simulation; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008954:Models, Biological; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult
keywords: magnetization transfer; relaxometry; synthetic quantitative MRI