title: Prevalence and Predictors of Metabolic Syndrome After Liver Transplantation.
abstract: BACKGROUND
  The development of metabolic syndrome (MS) after liver transplantation (LT) is a major source of mortality derived from cardiovascular events. The aim of the present study was to determine the prevalence and risk factors of MS after LT.
  
  
  METHODS
  One-hundred seventy-four consecutive LT patients from January 2004 to June 2010 surviving longer than 1 year after LT were included. Median follow-up after LT was 48 months. Independent predictors of MS were obtained by means of multivariate logistic regression.
  
  
  RESULTS
  At 3 years after LT, 25.5% of patients reached a body mass index (BMI) ≥30 kg/m2, 35.6% of patients developed arterial hypertension, 54.2% showed impaired fasting glucose, 22.5% had serum cholesterol >200 mg/dL, and 22.5% showed hypertriglyceridemia >150 mg/dL. The prevalence of MS ranged from 49% to 86% depending on the considered period. The pre-LT variables associated with MS were age at LT (odds ratio [OR], 1.08; P = .002), BMI of recipient before LT (OR, 1.23; P = .001), serum glucose (OR, 1.02; P = .005), and non-heart-beating donor (OR, 1.02; P = .046). The post-LT predictors of MS were body weight (OR, 1.04; P = .005), arterial hypertension (OR, 1.02; P = .047), and serum glucose (OR, 1.02; P = .011) at 6 months.
  
  
  CONCLUSIONS
  LT patients develop MS in a high proportion and progressively despite current efforts (ie, lifestyle modifications and aggressive management of hypertension, diabetes, and hyperlipidemia). The associated risk factors include age, increased BMI, and pre- and post-LT glucose.
authors.affiliation: Department of Gastroenterology, Hospital Infanta Margarita, Cabra (Cordoba), Spain. Electronic address: lvp80@hotmail.com.
authors.forename: L
authors.initials: L
authors.lastname: Vida Perez
authors.affiliation: Clinical Management Unit of Gastroenterology, Section of Hepatology and Liver Transplantation, Hospital Universitario Reina Sofía, Cordoba, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: Montero Alvarez
authors.affiliation: Clinical Management Unit of Gastroenterology, Section of Hepatology and Liver Transplantation, Hospital Universitario Reina Sofía, Cordoba, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Poyato Gonzalez
authors.affiliation: Hepatobilliary and Pancreatic Surgery Unit, Hospital Universitario Reina Sofía, Cordoba, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Briceño Delgado
authors.affiliation: Clinical Management Unit of Gastroenterology, Section of Hepatology and Liver Transplantation, Hospital Universitario Reina Sofía, Cordoba, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Costan Rodero
authors.affiliation: Clinical Management Unit of Gastroenterology, Section of Hepatology and Liver Transplantation, Hospital Universitario Reina Sofía, Cordoba, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Fraga Rivas
authors.affiliation: Clinical Management Unit of Gastroenterology, Section of Hepatology and Liver Transplantation, Hospital Universitario Reina Sofía, Cordoba, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Barrera Baena
authors.affiliation: Clinical Management Unit of Gastroenterology, Section of Hepatology and Liver Transplantation, Hospital Universitario Reina Sofía, Cordoba, Spain.
authors.forename: M
authors.initials: M
authors.lastname: De la Mata Garcia
mesh_terms: D000328:Adult; D015992:Body Mass Index; D003920:Diabetes Mellitus; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D006973:Hypertension / Q000150:complications; D016031:Liver Transplantation / Q000009:adverse effects*; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D012307:Risk Factors