title: Chronic Obstructive Pulmonary Disease: Lobar Analysis with Hyperpolarized129Xe MR Imaging.
abstract: Purpose To compare lobar ventilation and apparent diffusion coefficient (ADC) values obtained with hyperpolarized xenon 129 (129Xe) magnetic resonance (MR) imaging to quantitative computed tomography (CT) metrics on a lobar basis and pulmonary function test (PFT) results on a whole-lung basis in patients with chronic obstructive pulmonary disease (COPD). Materials and Methods The study was approved by the National Research Ethics Service Committee; written informed consent was obtained from all patients. Twenty-two patients with COPD (Global Initiative for Chronic Obstructive Lung Disease stage II-IV) underwent hyperpolarized129Xe MR imaging at 1.5 T, quantitative CT, and PFTs. Whole-lung and lobar129Xe MR imaging parameters were obtained by using automated segmentation of multisection hyperpolarized129Xe MR ventilation images and hyperpolarized129Xe MR diffusion-weighted images after coregistration to CT scans. Whole-lung and lobar quantitative CT-derived metrics for emphysema and bronchial wall thickness were calculated. Pearson correlation coefficients were used to evaluate the relationship between imaging measures and PFT results. Results Percentage ventilated volume and average ADC at lobar129Xe MR imaging showed correlation with percentage emphysema at lobar quantitative CT (r = -0.32, P < .001 and r = 0.75, P < .0001, respectively). The average ADC at whole-lung129Xe MR imaging showed moderate correlation with PFT results (percentage predicted transfer factor of the lung for carbon monoxide [Tlco]: r = -0.61, P < .005) and percentage predicted functional residual capacity (r = 0.47, P < .05). Whole-lung quantitative CT percentage emphysema also showed statistically significant correlation with percentage predicted Tlco (r = -0.65, P < .005). Conclusion Lobar ventilation and ADC values obtained from hyperpolarized129Xe MR imaging demonstrated correlation with quantitative CT percentage emphysema on a lobar basis and with PFT results on a whole-lung basis.©RSNA, 2016.
authors.affiliation: From the Department of Radiology (T.N.M., M.C., X.X., F.V.G.) and Oxford Centre for Respiratory Medicine (N.R., A.H.N.), The Churchill Hospital, Oxford University Hospitals NHS Trust, Old Rd, Headington, OX3 7LE, England; Unit of Academic Radiology, Royal Hallamshire Hospital, University of Sheffield, Sheffield, England (N.J.S., J.M.W.); and Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Headington, England (T.D., V.G.).
authors.forename: Tahreema N
authors.initials: TN
authors.lastname: Matin
authors.affiliation: From the Department of Radiology (T.N.M., M.C., X.X., F.V.G.) and Oxford Centre for Respiratory Medicine (N.R., A.H.N.), The Churchill Hospital, Oxford University Hospitals NHS Trust, Old Rd, Headington, OX3 7LE, England; Unit of Academic Radiology, Royal Hallamshire Hospital, University of Sheffield, Sheffield, England (N.J.S., J.M.W.); and Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Headington, England (T.D., V.G.).
authors.forename: Najib
authors.initials: N
authors.lastname: Rahman
authors.affiliation: From the Department of Radiology (T.N.M., M.C., X.X., F.V.G.) and Oxford Centre for Respiratory Medicine (N.R., A.H.N.), The Churchill Hospital, Oxford University Hospitals NHS Trust, Old Rd, Headington, OX3 7LE, England; Unit of Academic Radiology, Royal Hallamshire Hospital, University of Sheffield, Sheffield, England (N.J.S., J.M.W.); and Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Headington, England (T.D., V.G.).
authors.forename: Annabel H
authors.initials: AH
authors.lastname: Nickol
authors.affiliation: From the Department of Radiology (T.N.M., M.C., X.X., F.V.G.) and Oxford Centre for Respiratory Medicine (N.R., A.H.N.), The Churchill Hospital, Oxford University Hospitals NHS Trust, Old Rd, Headington, OX3 7LE, England; Unit of Academic Radiology, Royal Hallamshire Hospital, University of Sheffield, Sheffield, England (N.J.S., J.M.W.); and Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Headington, England (T.D., V.G.).
authors.forename: Mitchell
authors.initials: M
authors.lastname: Chen
authors.affiliation: From the Department of Radiology (T.N.M., M.C., X.X., F.V.G.) and Oxford Centre for Respiratory Medicine (N.R., A.H.N.), The Churchill Hospital, Oxford University Hospitals NHS Trust, Old Rd, Headington, OX3 7LE, England; Unit of Academic Radiology, Royal Hallamshire Hospital, University of Sheffield, Sheffield, England (N.J.S., J.M.W.); and Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Headington, England (T.D., V.G.).
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Xu
authors.affiliation: From the Department of Radiology (T.N.M., M.C., X.X., F.V.G.) and Oxford Centre for Respiratory Medicine (N.R., A.H.N.), The Churchill Hospital, Oxford University Hospitals NHS Trust, Old Rd, Headington, OX3 7LE, England; Unit of Academic Radiology, Royal Hallamshire Hospital, University of Sheffield, Sheffield, England (N.J.S., J.M.W.); and Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Headington, England (T.D., V.G.).
authors.forename: Neil J
authors.initials: NJ
authors.lastname: Stewart
authors.affiliation: From the Department of Radiology (T.N.M., M.C., X.X., F.V.G.) and Oxford Centre for Respiratory Medicine (N.R., A.H.N.), The Churchill Hospital, Oxford University Hospitals NHS Trust, Old Rd, Headington, OX3 7LE, England; Unit of Academic Radiology, Royal Hallamshire Hospital, University of Sheffield, Sheffield, England (N.J.S., J.M.W.); and Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Headington, England (T.D., V.G.).
authors.forename: Tom
authors.initials: T
authors.lastname: Doel
authors.affiliation: From the Department of Radiology (T.N.M., M.C., X.X., F.V.G.) and Oxford Centre for Respiratory Medicine (N.R., A.H.N.), The Churchill Hospital, Oxford University Hospitals NHS Trust, Old Rd, Headington, OX3 7LE, England; Unit of Academic Radiology, Royal Hallamshire Hospital, University of Sheffield, Sheffield, England (N.J.S., J.M.W.); and Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Headington, England (T.D., V.G.).
authors.forename: Vicente
authors.initials: V
authors.lastname: Grau
authors.affiliation: From the Department of Radiology (T.N.M., M.C., X.X., F.V.G.) and Oxford Centre for Respiratory Medicine (N.R., A.H.N.), The Churchill Hospital, Oxford University Hospitals NHS Trust, Old Rd, Headington, OX3 7LE, England; Unit of Academic Radiology, Royal Hallamshire Hospital, University of Sheffield, Sheffield, England (N.J.S., J.M.W.); and Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Headington, England (T.D., V.G.).
authors.forename: James M
authors.initials: JM
authors.lastname: Wild
authors.affiliation: From the Department of Radiology (T.N.M., M.C., X.X., F.V.G.) and Oxford Centre for Respiratory Medicine (N.R., A.H.N.), The Churchill Hospital, Oxford University Hospitals NHS Trust, Old Rd, Headington, OX3 7LE, England; Unit of Academic Radiology, Royal Hallamshire Hospital, University of Sheffield, Sheffield, England (N.J.S., J.M.W.); and Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Headington, England (T.D., V.G.).
authors.forename: Fergus V
authors.initials: FV
authors.lastname: Gleeson
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000000981:diagnostic imaging* / Q000473:pathology; D015203:Reproducibility of Results; D014979:Xenon Isotopes
chemical_list: D014979:Xenon Isotopes