title: Chronic Diarrhea Associated with High Teriflunomide Blood Concentration.
abstract: OBJECTIVE
  To report the case of a patient treated with leflunomide that presented with chronic diarrhea associated with high teriflunomide blood concentration. An 84-year-old woman taking leflunomide 20 mg once daily for the past 2 years to treat rheumatoid arthritis (RA) was investigated for severe chronic diarrhea that had been worsening for the past 5 months. The patient's general condition progressively deteriorated and included electrolyte imbalances and a transient loss of consciousness. Therefore, hospitalization was required. Teriflunomide blood concentration was 156 mg/L. After 11 days of cholestyramine washout therapy, teriflunomide blood concentration was reduced to 6 mg/L. As the teriflunomide levels decreased, diarrhea improved. All other possible causes of diarrhea were ruled out. The patient's diarrhea finally resolved 26 days after treatment with cholestyramine.
  
  
  CONCLUSIONS
  Diarrhea is a known adverse effect of leflunomide. In this report, the severe diarrhea was associated with high blood teriflunomide concentrations. Available data suggests an association between teriflunomide concentrations greater than 50 mg/L and lower disease activity, but toxic teriflunomide levels still have to be clarified.
  
  
  CONCLUSIONS
  Further studies are needed to establish the optimal therapeutic levels of teriflunomide. However, therapeutic drug monitoring of teriflunomide blood concentrations may be helpful to improve effectiveness and to prevent toxicity in patients taking leflunomide for RA, particularly in those with suboptimal therapeutic response to leflunomide or in patients with toxicity suspected to be induced by leflunomide.
authors.affiliation: Faculty of Pharmacy, University of Montreal, Montreal, QC, Canada. andre1duquette@gmail.com.
authors.forename: André
authors.identifier: http://orcid.org/0000-0003-3524-1018
authors.initials: A
authors.lastname: Duquette
authors.affiliation: Faculty of Pharmacy, University of Montreal, Montreal, QC, Canada.|Department of Pharmacy, Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada.|Research Center, Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada.
authors.forename: Anne Julie
authors.initials: AJ
authors.lastname: Frenette
authors.affiliation: Department of Pharmacy, Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada.
authors.forename: Maxime
authors.initials: M
authors.lastname: Doré
keywords: Cholestyramine; Diarrhea; Leflunomide; Teriflunomide; Therapeutic drug monitoring; Toxic concentrations; Washout