title: Hydrodynamic thermal confinement: creating thermo-chemical microenvironments on surfaces.
abstract: We present a new, general concept termed Hydrodynamic Thermal Confinement (HTC), and its implementation for the creation of microscale dynamic thermo-chemical microenvironments on biological surfaces. HTC is based on a scanning probe and operates under physiological conditions. The temperature can be regulated between 30° and 80 °C with ±0.2 °C precision and temperature ramps of 5 °C s-1over a footprint of ∼50 μm × 80 μm in a volume of ∼50 × 80 × 15 μm3(∼50 pl).
authors.affiliation: IBM Research - Zurich, Säumerstrasse 4, 8803 Rüschlikon, Switzerland. gov@zurich.ibm.com.
authors.forename: J F
authors.initials: JF
authors.lastname: Cors
authors.affiliation: IBM Research - Zurich, Säumerstrasse 4, 8803 Rüschlikon, Switzerland. gov@zurich.ibm.com.
authors.forename: A
authors.initials: A
authors.lastname: Stucki
authors.affiliation: IBM Research - Zurich, Säumerstrasse 4, 8803 Rüschlikon, Switzerland. gov@zurich.ibm.com.
authors.forename: G V
authors.initials: GV
authors.lastname: Kaigala