title: Procedural and Long-Term Outcomes of Bioresorbable Scaffolds Versus Drug-Eluting Stents in Chronic Total Occlusions: The BONITO Registry (Bioresorbable Scaffolds Versus Drug-Eluting Stents in Chronic Total Occlusions).
abstract: There is little evidence regarding the efficacy and safety of bioresorbable scaffolds (BRS) for the percutaneous treatment of chronic total occlusions.
  
  
  
  We performed a multicenter registry of consecutive chronic total occlusion patients treated with BRS (Absorb; Abbott Vascular) and second-generation drug-eluting stents (DES) at 5 institutions. Long-term target-vessel failure (a composite of cardiac death, target-vessel myocardial infarction, and ischemia-driven target-lesion revascularization) was the primary end point. Inverse probability of treatment weight-adjusted Cox regression was used to account for pretreatment differences between the 2 groups. A total of 537 patients (n=153 BRS; n=384 DES) were included. BRS patients were younger and had lower prevalence of comorbidities. Overall mean Japan-Chronic Total Occlusion (J-CTO) score was 1.43±1.16, with no differences between groups. Procedural success was achieved in 99.3% and 96.6% of BRS- and DES-treated patients, respectively (P=0.07). At a median follow-up of 703 days, there were no differences in target-vessel failure between BRS and DES (4.6% versus 7.7%; P=0.21). By adjusted Cox regression analysis, there were still no significant differences between BRS and DES (hazard ratio, 1.54; 95% confidence interval, 0.69-3.72; P=0.34). However, secondary analyses suggested a signal toward higher ischemia-driven target-lesion revascularization with BRS.
  
  
  
  Implantation of BRS versus second-generation DES in chronic total occlusion was associated with similar risk of target-vessel failure at long-term follow-up. However, a signal toward increased ischemia-driven target-lesion revascularization with BRS was observed. Large randomized studies should confirm these findings.
authors.affiliation: From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sofía Hospital, University of Córdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit, Division of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (A.S., L.L.G.); Division of Cardiology, Ferrarotto Hospital and Policlinico Vittorio Emanuele University Hospitals, Catania, Italy (A.L.M., G.L., E.M., G.D., C.T.); and Interventional Cardiology Division, Department of Medicine, Montreal Heart Institute, University of Montreal, QC, Canada (H.Q.L., F.P.). azzalini.lorenzo@hsr.it.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Azzalini
authors.affiliation: From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sofía Hospital, University of Córdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit, Division of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (A.S., L.L.G.); Division of Cardiology, Ferrarotto Hospital and Policlinico Vittorio Emanuele University Hospitals, Catania, Italy (A.L.M., G.L., E.M., G.D., C.T.); and Interventional Cardiology Division, Department of Medicine, Montreal Heart Institute, University of Montreal, QC, Canada (H.Q.L., F.P.).
authors.forename: Gennaro
authors.initials: G
authors.lastname: Giustino
authors.affiliation: From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sofía Hospital, University of Córdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit, Division of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (A.S., L.L.G.); Division of Cardiology, Ferrarotto Hospital and Policlinico Vittorio Emanuele University Hospitals, Catania, Italy (A.L.M., G.L., E.M., G.D., C.T.); and Interventional Cardiology Division, Department of Medicine, Montreal Heart Institute, University of Montreal, QC, Canada (H.Q.L., F.P.).
authors.forename: Soledad
authors.initials: S
authors.lastname: Ojeda
authors.affiliation: From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sofía Hospital, University of Córdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit, Division of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (A.S., L.L.G.); Division of Cardiology, Ferrarotto Hospital and Policlinico Vittorio Emanuele University Hospitals, Catania, Italy (A.L.M., G.L., E.M., G.D., C.T.); and Interventional Cardiology Division, Department of Medicine, Montreal Heart Institute, University of Montreal, QC, Canada (H.Q.L., F.P.).
authors.forename: Antonio
authors.initials: A
authors.lastname: Serra
authors.affiliation: From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sofía Hospital, University of Córdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit, Division of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (A.S., L.L.G.); Division of Cardiology, Ferrarotto Hospital and Policlinico Vittorio Emanuele University Hospitals, Catania, Italy (A.L.M., G.L., E.M., G.D., C.T.); and Interventional Cardiology Division, Department of Medicine, Montreal Heart Institute, University of Montreal, QC, Canada (H.Q.L., F.P.).
authors.forename: Alessio
authors.initials: A
authors.lastname: La Manna
authors.affiliation: From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sofía Hospital, University of Córdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit, Division of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (A.S., L.L.G.); Division of Cardiology, Ferrarotto Hospital and Policlinico Vittorio Emanuele University Hospitals, Catania, Italy (A.L.M., G.L., E.M., G.D., C.T.); and Interventional Cardiology Division, Department of Medicine, Montreal Heart Institute, University of Montreal, QC, Canada (H.Q.L., F.P.).
authors.forename: Hung Q
authors.initials: HQ
authors.lastname: Ly
authors.affiliation: From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sofía Hospital, University of Córdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit, Division of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (A.S., L.L.G.); Division of Cardiology, Ferrarotto Hospital and Policlinico Vittorio Emanuele University Hospitals, Catania, Italy (A.L.M., G.L., E.M., G.D., C.T.); and Interventional Cardiology Division, Department of Medicine, Montreal Heart Institute, University of Montreal, QC, Canada (H.Q.L., F.P.).
authors.forename: Barbara
authors.initials: B
authors.lastname: Bellini
authors.affiliation: From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sofía Hospital, University of Córdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit, Division of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (A.S., L.L.G.); Division of Cardiology, Ferrarotto Hospital and Policlinico Vittorio Emanuele University Hospitals, Catania, Italy (A.L.M., G.L., E.M., G.D., C.T.); and Interventional Cardiology Division, Department of Medicine, Montreal Heart Institute, University of Montreal, QC, Canada (H.Q.L., F.P.).
authors.forename: Susanna
authors.initials: S
authors.lastname: Benincasa
authors.affiliation: From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sofía Hospital, University of Córdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit, Division of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (A.S., L.L.G.); Division of Cardiology, Ferrarotto Hospital and Policlinico Vittorio Emanuele University Hospitals, Catania, Italy (A.L.M., G.L., E.M., G.D., C.T.); and Interventional Cardiology Division, Department of Medicine, Montreal Heart Institute, University of Montreal, QC, Canada (H.Q.L., F.P.).
authors.forename: Jorge
authors.initials: J
authors.lastname: Chavarría
authors.affiliation: From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sofía Hospital, University of Córdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit, Division of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (A.S., L.L.G.); Division of Cardiology, Ferrarotto Hospital and Policlinico Vittorio Emanuele University Hospitals, Catania, Italy (A.L.M., G.L., E.M., G.D., C.T.); and Interventional Cardiology Division, Department of Medicine, Montreal Heart Institute, University of Montreal, QC, Canada (H.Q.L., F.P.).
authors.forename: Livia L
authors.initials: LL
authors.lastname: Gheorghe
authors.affiliation: From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sofía Hospital, University of Córdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit, Division of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (A.S., L.L.G.); Division of Cardiology, Ferrarotto Hospital and Policlinico Vittorio Emanuele University Hospitals, Catania, Italy (A.L.M., G.L., E.M., G.D., C.T.); and Interventional Cardiology Division, Department of Medicine, Montreal Heart Institute, University of Montreal, QC, Canada (H.Q.L., F.P.).
authors.forename: Giovanni
authors.initials: G
authors.lastname: Longo
authors.affiliation: From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sofía Hospital, University of Córdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit, Division of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (A.S., L.L.G.); Division of Cardiology, Ferrarotto Hospital and Policlinico Vittorio Emanuele University Hospitals, Catania, Italy (A.L.M., G.L., E.M., G.D., C.T.); and Interventional Cardiology Division, Department of Medicine, Montreal Heart Institute, University of Montreal, QC, Canada (H.Q.L., F.P.).
authors.forename: Eligio
authors.initials: E
authors.lastname: Miccichè
authors.affiliation: From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sofía Hospital, University of Córdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit, Division of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (A.S., L.L.G.); Division of Cardiology, Ferrarotto Hospital and Policlinico Vittorio Emanuele University Hospitals, Catania, Italy (A.L.M., G.L., E.M., G.D., C.T.); and Interventional Cardiology Division, Department of Medicine, Montreal Heart Institute, University of Montreal, QC, Canada (H.Q.L., F.P.).
authors.forename: Guido
authors.initials: G
authors.lastname: D'Agosta
authors.affiliation: From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sofía Hospital, University of Córdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit, Division of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (A.S., L.L.G.); Division of Cardiology, Ferrarotto Hospital and Policlinico Vittorio Emanuele University Hospitals, Catania, Italy (A.L.M., G.L., E.M., G.D., C.T.); and Interventional Cardiology Division, Department of Medicine, Montreal Heart Institute, University of Montreal, QC, Canada (H.Q.L., F.P.).
authors.forename: Fabien
authors.initials: F
authors.lastname: Picard
authors.affiliation: From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sofía Hospital, University of Córdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit, Division of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (A.S., L.L.G.); Division of Cardiology, Ferrarotto Hospital and Policlinico Vittorio Emanuele University Hospitals, Catania, Italy (A.L.M., G.L., E.M., G.D., C.T.); and Interventional Cardiology Division, Department of Medicine, Montreal Heart Institute, University of Montreal, QC, Canada (H.Q.L., F.P.).
authors.forename: Manuel
authors.initials: M
authors.lastname: Pan
authors.affiliation: From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sofía Hospital, University of Córdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit, Division of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (A.S., L.L.G.); Division of Cardiology, Ferrarotto Hospital and Policlinico Vittorio Emanuele University Hospitals, Catania, Italy (A.L.M., G.L., E.M., G.D., C.T.); and Interventional Cardiology Division, Department of Medicine, Montreal Heart Institute, University of Montreal, QC, Canada (H.Q.L., F.P.).
authors.forename: Corrado
authors.initials: C
authors.lastname: Tamburino
authors.affiliation: From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sofía Hospital, University of Córdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit, Division of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (A.S., L.L.G.); Division of Cardiology, Ferrarotto Hospital and Policlinico Vittorio Emanuele University Hospitals, Catania, Italy (A.L.M., G.L., E.M., G.D., C.T.); and Interventional Cardiology Division, Department of Medicine, Montreal Heart Institute, University of Montreal, QC, Canada (H.Q.L., F.P.).
authors.forename: Azeem
authors.initials: A
authors.lastname: Latib
authors.affiliation: From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sofía Hospital, University of Córdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit, Division of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (A.S., L.L.G.); Division of Cardiology, Ferrarotto Hospital and Policlinico Vittorio Emanuele University Hospitals, Catania, Italy (A.L.M., G.L., E.M., G.D., C.T.); and Interventional Cardiology Division, Department of Medicine, Montreal Heart Institute, University of Montreal, QC, Canada (H.Q.L., F.P.).
authors.forename: Mauro
authors.initials: M
authors.lastname: Carlino
authors.affiliation: From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sofía Hospital, University of Córdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit, Division of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (A.S., L.L.G.); Division of Cardiology, Ferrarotto Hospital and Policlinico Vittorio Emanuele University Hospitals, Catania, Italy (A.L.M., G.L., E.M., G.D., C.T.); and Interventional Cardiology Division, Department of Medicine, Montreal Heart Institute, University of Montreal, QC, Canada (H.Q.L., F.P.).
authors.forename: Alaide
authors.initials: A
authors.lastname: Chieffo
authors.affiliation: From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sofía Hospital, University of Córdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit, Division of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (A.S., L.L.G.); Division of Cardiology, Ferrarotto Hospital and Policlinico Vittorio Emanuele University Hospitals, Catania, Italy (A.L.M., G.L., E.M., G.D., C.T.); and Interventional Cardiology Division, Department of Medicine, Montreal Heart Institute, University of Montreal, QC, Canada (H.Q.L., F.P.).
authors.forename: Antonio
authors.initials: A
authors.lastname: Colombo
mesh_terms: D020341:Absorbable Implants; D000368:Aged; D002317:Cardiovascular Agents / Q000008:administration & dosage*; D016009:Chi-Square Distribution; D002908:Chronic Disease; D020099:Coated Materials, Biocompatible; D015897:Comorbidity; D017023:Coronary Angiography; D054059:Coronary Occlusion / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy*; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000209:etiology; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000295:instrumentation* / Q000401:mortality; D057216:Propensity Score; D016016:Proportional Hazards Models; D011474:Prosthesis Design; D012042:Registries; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D002317:Cardiovascular Agents; D020099:Coated Materials, Biocompatible
keywords: comorbidity; drug-eluting stents; follow-up studies; myocardial infarction; regression analysis