title: Vulvar, Perianal and Perineal Cancer After Hidradenitis Suppurativa: A Systematic Review and Pooled Analysis.
abstract: BACKGROUND
  Hidradenitis suppurativa (HS) is a chronic inflammatory disease that frequently involves the perineal and perianal regions. The association between HS and malignant transformation is a rare but under recognized phenomenon.
  
  
  OBJECTIVE
  This systematic review aims to summarize all available cases of vulvar and perianal/perineal cancer emerging in patients with HS, describing clinical and therapeutic particularities of these coexisting conditions in female patients.
  
  
  METHODS
  This systematic review and pooled analysis was performed in accordance with the PRISMA guidelines; end-of-search date was June 15, 2015.
  
  
  RESULTS
  A total of 13 eligible articles were identified; 7 cases of vulvar cancer and 6 cases of perineal/perianal carcinomas in patients with HS were noted. A majority of published cases pertained to rather advanced carcinomas; only occasionally early stage carcinomas were identified. The optimal modifications in the treatment scheme of vulvar, perianal, and perineal cancer in patients with HS have not been established; detailed reporting of recurrence- and survival-related aspects is advised.
  
  
  CONCLUSIONS
  Vulvar, perianal, and perineal cancer represent a rare but serious complication of HS.
authors.affiliation: *Department of Obstetrics and Gynecology, Rea Maternity Hospital, Athens, Greece; †Department of Breast Surgery, Euroclinic of Athens, Athens, Greece; ‡Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Georgios-Marios
authors.initials: GM
authors.lastname: Makris
authors.forename: Nikiforita
authors.initials: N
authors.lastname: Poulakaki
authors.forename: Aristea-Maria
authors.initials: AM
authors.lastname: Papanota
authors.forename: Evgenia
authors.initials: E
authors.lastname: Kotsifa
authors.forename: Theodoros N
authors.initials: TN
authors.lastname: Sergentanis
authors.forename: Theodora
authors.initials: T
authors.lastname: Psaltopoulou
mesh_terms: D002081:Buttocks; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000556:secondary / Q000628:therapy; D005260:Female; D017497:Hidradenitis Suppurativa / Q000150:complications*; D006801:Humans; D010502:Perineum; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D014846:Vulvar Neoplasms / Q000209:etiology* / Q000473:pathology / Q000628:therapy