title: Neuroinflammatory and morphological changes in late-life depression: the NIMROD study.
abstract: We studied neuroinflammation in individuals with late-life depression, as a risk factor for dementia, using [11C]PK11195 positron emission tomography (PET). Five older participants with major depression and 13 controls underwent PET and multimodal 3T magnetic resonance imaging (MRI), with blood taken to measure C-reactive protein (CRP). We found significantly higher CRP levels in those with late-life depression and raised [11C]PK11195 binding compared with controls in brain regions associated with depression, including subgenual anterior cingulate cortex, and significant hippocampal subfield atrophy in cornu ammonis 1 and subiculum. Our findings suggest neuroinflammation requires further investigation in late-life depression, both as a possible aetiological factor and a potential therapeutic target.
authors.affiliation: Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, UK; Silvy Gabel, MSc, Department of Psychiatry, University of Cambridge, UK and Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands; Lawrence Hayes, MBBS, Soteris Soteriades, BA, Department of Psychiatry, University of Cambridge, UK; Guy B. Williams, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Robert Arnold, BSc, Department of Psychiatry, University of Cambridge, UK; Luca Passamonti, MD, Patricia Vázquez Rodríguez, MSc, Department of Clinical Neurosciences, University of Cambridge, UK, Ajenthan Surendranathan, MRCP, Richard W. Bevan-Jones, MBBChir, Department of Psychiatry, University of Cambridge, UK; Jonathan Coles, PhD, Division of Anaesthesia, Department of Medicine, University of Cambridge, UK; Franklin Aigbirhio, DPhil, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; James B. Rowe, PhD, Department of Clinical Neurosciences, University of Cambridge and Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK; John T. O'Brien, DM, Department of Psychiatry, University of Cambridge, UK ls514@cam.ac.uk.
authors.forename: L
authors.initials: L
authors.lastname: Su
authors.affiliation: Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, UK; Silvy Gabel, MSc, Department of Psychiatry, University of Cambridge, UK and Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands; Lawrence Hayes, MBBS, Soteris Soteriades, BA, Department of Psychiatry, University of Cambridge, UK; Guy B. Williams, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Robert Arnold, BSc, Department of Psychiatry, University of Cambridge, UK; Luca Passamonti, MD, Patricia Vázquez Rodríguez, MSc, Department of Clinical Neurosciences, University of Cambridge, UK, Ajenthan Surendranathan, MRCP, Richard W. Bevan-Jones, MBBChir, Department of Psychiatry, University of Cambridge, UK; Jonathan Coles, PhD, Division of Anaesthesia, Department of Medicine, University of Cambridge, UK; Franklin Aigbirhio, DPhil, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; James B. Rowe, PhD, Department of Clinical Neurosciences, University of Cambridge and Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK; John T. O'Brien, DM, Department of Psychiatry, University of Cambridge, UK.
authors.forename: Y O
authors.initials: YO
authors.lastname: Faluyi
authors.affiliation: Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, UK; Silvy Gabel, MSc, Department of Psychiatry, University of Cambridge, UK and Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands; Lawrence Hayes, MBBS, Soteris Soteriades, BA, Department of Psychiatry, University of Cambridge, UK; Guy B. Williams, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Robert Arnold, BSc, Department of Psychiatry, University of Cambridge, UK; Luca Passamonti, MD, Patricia Vázquez Rodríguez, MSc, Department of Clinical Neurosciences, University of Cambridge, UK, Ajenthan Surendranathan, MRCP, Richard W. Bevan-Jones, MBBChir, Department of Psychiatry, University of Cambridge, UK; Jonathan Coles, PhD, Division of Anaesthesia, Department of Medicine, University of Cambridge, UK; Franklin Aigbirhio, DPhil, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; James B. Rowe, PhD, Department of Clinical Neurosciences, University of Cambridge and Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK; John T. O'Brien, DM, Department of Psychiatry, University of Cambridge, UK.
authors.forename: Y T
authors.initials: YT
authors.lastname: Hong
authors.affiliation: Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, UK; Silvy Gabel, MSc, Department of Psychiatry, University of Cambridge, UK and Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands; Lawrence Hayes, MBBS, Soteris Soteriades, BA, Department of Psychiatry, University of Cambridge, UK; Guy B. Williams, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Robert Arnold, BSc, Department of Psychiatry, University of Cambridge, UK; Luca Passamonti, MD, Patricia Vázquez Rodríguez, MSc, Department of Clinical Neurosciences, University of Cambridge, UK, Ajenthan Surendranathan, MRCP, Richard W. Bevan-Jones, MBBChir, Department of Psychiatry, University of Cambridge, UK; Jonathan Coles, PhD, Division of Anaesthesia, Department of Medicine, University of Cambridge, UK; Franklin Aigbirhio, DPhil, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; James B. Rowe, PhD, Department of Clinical Neurosciences, University of Cambridge and Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK; John T. O'Brien, DM, Department of Psychiatry, University of Cambridge, UK.
authors.forename: T D
authors.initials: TD
authors.lastname: Fryer
authors.affiliation: Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, UK; Silvy Gabel, MSc, Department of Psychiatry, University of Cambridge, UK and Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands; Lawrence Hayes, MBBS, Soteris Soteriades, BA, Department of Psychiatry, University of Cambridge, UK; Guy B. Williams, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Robert Arnold, BSc, Department of Psychiatry, University of Cambridge, UK; Luca Passamonti, MD, Patricia Vázquez Rodríguez, MSc, Department of Clinical Neurosciences, University of Cambridge, UK, Ajenthan Surendranathan, MRCP, Richard W. Bevan-Jones, MBBChir, Department of Psychiatry, University of Cambridge, UK; Jonathan Coles, PhD, Division of Anaesthesia, Department of Medicine, University of Cambridge, UK; Franklin Aigbirhio, DPhil, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; James B. Rowe, PhD, Department of Clinical Neurosciences, University of Cambridge and Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK; John T. O'Brien, DM, Department of Psychiatry, University of Cambridge, UK.
authors.forename: E
authors.initials: E
authors.lastname: Mak
authors.affiliation: Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, UK; Silvy Gabel, MSc, Department of Psychiatry, University of Cambridge, UK and Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands; Lawrence Hayes, MBBS, Soteris Soteriades, BA, Department of Psychiatry, University of Cambridge, UK; Guy B. Williams, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Robert Arnold, BSc, Department of Psychiatry, University of Cambridge, UK; Luca Passamonti, MD, Patricia Vázquez Rodríguez, MSc, Department of Clinical Neurosciences, University of Cambridge, UK, Ajenthan Surendranathan, MRCP, Richard W. Bevan-Jones, MBBChir, Department of Psychiatry, University of Cambridge, UK; Jonathan Coles, PhD, Division of Anaesthesia, Department of Medicine, University of Cambridge, UK; Franklin Aigbirhio, DPhil, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; James B. Rowe, PhD, Department of Clinical Neurosciences, University of Cambridge and Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK; John T. O'Brien, DM, Department of Psychiatry, University of Cambridge, UK.
authors.forename: S
authors.initials: S
authors.lastname: Gabel
authors.affiliation: Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, UK; Silvy Gabel, MSc, Department of Psychiatry, University of Cambridge, UK and Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands; Lawrence Hayes, MBBS, Soteris Soteriades, BA, Department of Psychiatry, University of Cambridge, UK; Guy B. Williams, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Robert Arnold, BSc, Department of Psychiatry, University of Cambridge, UK; Luca Passamonti, MD, Patricia Vázquez Rodríguez, MSc, Department of Clinical Neurosciences, University of Cambridge, UK, Ajenthan Surendranathan, MRCP, Richard W. Bevan-Jones, MBBChir, Department of Psychiatry, University of Cambridge, UK; Jonathan Coles, PhD, Division of Anaesthesia, Department of Medicine, University of Cambridge, UK; Franklin Aigbirhio, DPhil, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; James B. Rowe, PhD, Department of Clinical Neurosciences, University of Cambridge and Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK; John T. O'Brien, DM, Department of Psychiatry, University of Cambridge, UK.
authors.forename: L
authors.initials: L
authors.lastname: Hayes
authors.affiliation: Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, UK; Silvy Gabel, MSc, Department of Psychiatry, University of Cambridge, UK and Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands; Lawrence Hayes, MBBS, Soteris Soteriades, BA, Department of Psychiatry, University of Cambridge, UK; Guy B. Williams, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Robert Arnold, BSc, Department of Psychiatry, University of Cambridge, UK; Luca Passamonti, MD, Patricia Vázquez Rodríguez, MSc, Department of Clinical Neurosciences, University of Cambridge, UK, Ajenthan Surendranathan, MRCP, Richard W. Bevan-Jones, MBBChir, Department of Psychiatry, University of Cambridge, UK; Jonathan Coles, PhD, Division of Anaesthesia, Department of Medicine, University of Cambridge, UK; Franklin Aigbirhio, DPhil, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; James B. Rowe, PhD, Department of Clinical Neurosciences, University of Cambridge and Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK; John T. O'Brien, DM, Department of Psychiatry, University of Cambridge, UK.
authors.forename: S
authors.initials: S
authors.lastname: Soteriades
authors.affiliation: Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, UK; Silvy Gabel, MSc, Department of Psychiatry, University of Cambridge, UK and Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands; Lawrence Hayes, MBBS, Soteris Soteriades, BA, Department of Psychiatry, University of Cambridge, UK; Guy B. Williams, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Robert Arnold, BSc, Department of Psychiatry, University of Cambridge, UK; Luca Passamonti, MD, Patricia Vázquez Rodríguez, MSc, Department of Clinical Neurosciences, University of Cambridge, UK, Ajenthan Surendranathan, MRCP, Richard W. Bevan-Jones, MBBChir, Department of Psychiatry, University of Cambridge, UK; Jonathan Coles, PhD, Division of Anaesthesia, Department of Medicine, University of Cambridge, UK; Franklin Aigbirhio, DPhil, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; James B. Rowe, PhD, Department of Clinical Neurosciences, University of Cambridge and Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK; John T. O'Brien, DM, Department of Psychiatry, University of Cambridge, UK.
authors.forename: G B
authors.initials: GB
authors.lastname: Williams
authors.affiliation: Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, UK; Silvy Gabel, MSc, Department of Psychiatry, University of Cambridge, UK and Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands; Lawrence Hayes, MBBS, Soteris Soteriades, BA, Department of Psychiatry, University of Cambridge, UK; Guy B. Williams, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Robert Arnold, BSc, Department of Psychiatry, University of Cambridge, UK; Luca Passamonti, MD, Patricia Vázquez Rodríguez, MSc, Department of Clinical Neurosciences, University of Cambridge, UK, Ajenthan Surendranathan, MRCP, Richard W. Bevan-Jones, MBBChir, Department of Psychiatry, University of Cambridge, UK; Jonathan Coles, PhD, Division of Anaesthesia, Department of Medicine, University of Cambridge, UK; Franklin Aigbirhio, DPhil, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; James B. Rowe, PhD, Department of Clinical Neurosciences, University of Cambridge and Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK; John T. O'Brien, DM, Department of Psychiatry, University of Cambridge, UK.
authors.forename: R
authors.initials: R
authors.lastname: Arnold
authors.affiliation: Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, UK; Silvy Gabel, MSc, Department of Psychiatry, University of Cambridge, UK and Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands; Lawrence Hayes, MBBS, Soteris Soteriades, BA, Department of Psychiatry, University of Cambridge, UK; Guy B. Williams, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Robert Arnold, BSc, Department of Psychiatry, University of Cambridge, UK; Luca Passamonti, MD, Patricia Vázquez Rodríguez, MSc, Department of Clinical Neurosciences, University of Cambridge, UK, Ajenthan Surendranathan, MRCP, Richard W. Bevan-Jones, MBBChir, Department of Psychiatry, University of Cambridge, UK; Jonathan Coles, PhD, Division of Anaesthesia, Department of Medicine, University of Cambridge, UK; Franklin Aigbirhio, DPhil, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; James B. Rowe, PhD, Department of Clinical Neurosciences, University of Cambridge and Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK; John T. O'Brien, DM, Department of Psychiatry, University of Cambridge, UK.
authors.forename: L
authors.initials: L
authors.lastname: Passamonti
authors.affiliation: Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, UK; Silvy Gabel, MSc, Department of Psychiatry, University of Cambridge, UK and Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands; Lawrence Hayes, MBBS, Soteris Soteriades, BA, Department of Psychiatry, University of Cambridge, UK; Guy B. Williams, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Robert Arnold, BSc, Department of Psychiatry, University of Cambridge, UK; Luca Passamonti, MD, Patricia Vázquez Rodríguez, MSc, Department of Clinical Neurosciences, University of Cambridge, UK, Ajenthan Surendranathan, MRCP, Richard W. Bevan-Jones, MBBChir, Department of Psychiatry, University of Cambridge, UK; Jonathan Coles, PhD, Division of Anaesthesia, Department of Medicine, University of Cambridge, UK; Franklin Aigbirhio, DPhil, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; James B. Rowe, PhD, Department of Clinical Neurosciences, University of Cambridge and Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK; John T. O'Brien, DM, Department of Psychiatry, University of Cambridge, UK.
authors.forename: P Vázquez
authors.initials: PV
authors.lastname: Rodríguez
authors.affiliation: Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, UK; Silvy Gabel, MSc, Department of Psychiatry, University of Cambridge, UK and Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands; Lawrence Hayes, MBBS, Soteris Soteriades, BA, Department of Psychiatry, University of Cambridge, UK; Guy B. Williams, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Robert Arnold, BSc, Department of Psychiatry, University of Cambridge, UK; Luca Passamonti, MD, Patricia Vázquez Rodríguez, MSc, Department of Clinical Neurosciences, University of Cambridge, UK, Ajenthan Surendranathan, MRCP, Richard W. Bevan-Jones, MBBChir, Department of Psychiatry, University of Cambridge, UK; Jonathan Coles, PhD, Division of Anaesthesia, Department of Medicine, University of Cambridge, UK; Franklin Aigbirhio, DPhil, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; James B. Rowe, PhD, Department of Clinical Neurosciences, University of Cambridge and Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK; John T. O'Brien, DM, Department of Psychiatry, University of Cambridge, UK.
authors.forename: A
authors.initials: A
authors.lastname: Surendranathan
authors.affiliation: Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, UK; Silvy Gabel, MSc, Department of Psychiatry, University of Cambridge, UK and Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands; Lawrence Hayes, MBBS, Soteris Soteriades, BA, Department of Psychiatry, University of Cambridge, UK; Guy B. Williams, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Robert Arnold, BSc, Department of Psychiatry, University of Cambridge, UK; Luca Passamonti, MD, Patricia Vázquez Rodríguez, MSc, Department of Clinical Neurosciences, University of Cambridge, UK, Ajenthan Surendranathan, MRCP, Richard W. Bevan-Jones, MBBChir, Department of Psychiatry, University of Cambridge, UK; Jonathan Coles, PhD, Division of Anaesthesia, Department of Medicine, University of Cambridge, UK; Franklin Aigbirhio, DPhil, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; James B. Rowe, PhD, Department of Clinical Neurosciences, University of Cambridge and Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK; John T. O'Brien, DM, Department of Psychiatry, University of Cambridge, UK.
authors.forename: R W
authors.initials: RW
authors.lastname: Bevan-Jones
authors.affiliation: Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, UK; Silvy Gabel, MSc, Department of Psychiatry, University of Cambridge, UK and Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands; Lawrence Hayes, MBBS, Soteris Soteriades, BA, Department of Psychiatry, University of Cambridge, UK; Guy B. Williams, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Robert Arnold, BSc, Department of Psychiatry, University of Cambridge, UK; Luca Passamonti, MD, Patricia Vázquez Rodríguez, MSc, Department of Clinical Neurosciences, University of Cambridge, UK, Ajenthan Surendranathan, MRCP, Richard W. Bevan-Jones, MBBChir, Department of Psychiatry, University of Cambridge, UK; Jonathan Coles, PhD, Division of Anaesthesia, Department of Medicine, University of Cambridge, UK; Franklin Aigbirhio, DPhil, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; James B. Rowe, PhD, Department of Clinical Neurosciences, University of Cambridge and Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK; John T. O'Brien, DM, Department of Psychiatry, University of Cambridge, UK.
authors.forename: J
authors.initials: J
authors.lastname: Coles
authors.affiliation: Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, UK; Silvy Gabel, MSc, Department of Psychiatry, University of Cambridge, UK and Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands; Lawrence Hayes, MBBS, Soteris Soteriades, BA, Department of Psychiatry, University of Cambridge, UK; Guy B. Williams, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Robert Arnold, BSc, Department of Psychiatry, University of Cambridge, UK; Luca Passamonti, MD, Patricia Vázquez Rodríguez, MSc, Department of Clinical Neurosciences, University of Cambridge, UK, Ajenthan Surendranathan, MRCP, Richard W. Bevan-Jones, MBBChir, Department of Psychiatry, University of Cambridge, UK; Jonathan Coles, PhD, Division of Anaesthesia, Department of Medicine, University of Cambridge, UK; Franklin Aigbirhio, DPhil, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; James B. Rowe, PhD, Department of Clinical Neurosciences, University of Cambridge and Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK; John T. O'Brien, DM, Department of Psychiatry, University of Cambridge, UK.
authors.forename: F
authors.initials: F
authors.lastname: Aigbirhio
authors.affiliation: Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, UK; Silvy Gabel, MSc, Department of Psychiatry, University of Cambridge, UK and Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands; Lawrence Hayes, MBBS, Soteris Soteriades, BA, Department of Psychiatry, University of Cambridge, UK; Guy B. Williams, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Robert Arnold, BSc, Department of Psychiatry, University of Cambridge, UK; Luca Passamonti, MD, Patricia Vázquez Rodríguez, MSc, Department of Clinical Neurosciences, University of Cambridge, UK, Ajenthan Surendranathan, MRCP, Richard W. Bevan-Jones, MBBChir, Department of Psychiatry, University of Cambridge, UK; Jonathan Coles, PhD, Division of Anaesthesia, Department of Medicine, University of Cambridge, UK; Franklin Aigbirhio, DPhil, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; James B. Rowe, PhD, Department of Clinical Neurosciences, University of Cambridge and Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK; John T. O'Brien, DM, Department of Psychiatry, University of Cambridge, UK.
authors.forename: J B
authors.initials: JB
authors.lastname: Rowe
authors.affiliation: Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, UK; Silvy Gabel, MSc, Department of Psychiatry, University of Cambridge, UK and Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands; Lawrence Hayes, MBBS, Soteris Soteriades, BA, Department of Psychiatry, University of Cambridge, UK; Guy B. Williams, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Robert Arnold, BSc, Department of Psychiatry, University of Cambridge, UK; Luca Passamonti, MD, Patricia Vázquez Rodríguez, MSc, Department of Clinical Neurosciences, University of Cambridge, UK, Ajenthan Surendranathan, MRCP, Richard W. Bevan-Jones, MBBChir, Department of Psychiatry, University of Cambridge, UK; Jonathan Coles, PhD, Division of Anaesthesia, Department of Medicine, University of Cambridge, UK; Franklin Aigbirhio, DPhil, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; James B. Rowe, PhD, Department of Clinical Neurosciences, University of Cambridge and Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK; John T. O'Brien, DM, Department of Psychiatry, University of Cambridge, UK.
authors.forename: J T
authors.initials: JT
authors.lastname: O'Brien
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000032:analysis*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D003865:Major Depressive Disorder / Q000097:blood / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology; D005260:Female; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000000981:diagnostic imaging / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D018079:Receptors, GABA / Q000378:metabolism*
chemical_list: D018079:Receptors, GABA; C499229:TSPO protein, human; D002097:C-Reactive Protein