title: The Intriguing Role of Histamine in Exercise Responses.
abstract: In humans, histamine is a molecular transducer of physical activity responses, and antihistamines modify more than 25% of the genes responding to exercise. Although the upstream signal that results in release of histamine within exercising skeletal muscle remains to be identified, it is likely a fundamental exercise response and not an allergic reaction.
authors.affiliation: Department of Human Physiology, University of Oregon, Eugene, OR.
authors.forename: Meredith J
authors.initials: MJ
authors.lastname: Luttrell
authors.forename: John R
authors.initials: JR
authors.lastname: Halliwill
mesh_terms: D054874:Athletic Performance / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D006339:Heart Rate / Q000502:physiology; D006632:Histamine / Q000378:metabolism / Q000502:physiology*; D006633:Histamine Antagonists / Q000494:pharmacology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D018482:Muscle, Skeletal / Q000378:metabolism; D058748:Pain Perception / Q000502:physiology; D011968:Receptors, Histamine / Q000378:metabolism; D014664:Vasodilation / Q000502:physiology
chemical_list: D006633:Histamine Antagonists; D011968:Receptors, Histamine; D006632:Histamine; D006003:Glycogen; D005947:Glucose