title: Fertility sparing surgery in gestational trophoblastic neoplasia: A report of 4 cases.
abstract: BACKGROUND
  Gestational trophoblastic neoplasia (GTN) is a curable disease that involves the development of malignant tumor in the woman after a normal or molar pregnancy. The position of surgery in GTN is not properly specified and is changing due to new chemotherapy protocols. However, the role of surgery is highlighted in chemotherapy-resistant GTN. Other indications of surgery in trophoblastic diseases are drug toxicity and uterine perforation. Based on the fact that most women in certain age tend to preserve fertility, this study reported 4 cases of successful treatment after fertility sparing surgery.
  
  
  METHODS
  A hospital-based case-report study was carried out to investigate the role of surgery in 4 patients with GTN. In this study, acute complications, such as intra-abdominal bleeding and liver dysfunction due to chemotherapy occurred in some patients. Surgery was performed and all cases underwent localized tumor removal while preserving the uterus. No hysterectomy surgery was performed.
  
  
  CONCLUSIONS
  Surgery is supposed in specific cases of GTN, who desire preserving fertility.
authors.affiliation: Department of Gynecologic Oncology, Women Health Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Malihe
authors.initials: M
authors.lastname: Hasanzadeh
authors.affiliation: Department of Gynecologic Oncology, Women Health Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Ftemeh
authors.initials: F
authors.lastname: Vahid Roodsari
authors.affiliation: Department of Obstetrics and Gynecology, Shahid Akbarabadi Hospital, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.; Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Ahmadi
authors.affiliation: Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Masoumeh
authors.initials: M
authors.lastname: Gavedan Mehr
authors.affiliation: Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Tabari
authors.initials: T
authors.lastname: Azadeh
keywords: Chemotherapy; Fertility; GTT; Surgery