title: Extraversion and neuroticism related to the resting-state effective connectivity of amygdala.
abstract: The amygdala plays a key role in emotion processing. Its functional connectivity with other brain regions has been extensively demonstrated to be associated with extraversion and neuroticism. However, how the amygdala affects other regions and is affected by others within these connectivity patterns associated with extraversion and neuroticism remains unclear. To address this issue, we investigated the effective connectivity of the amygdala using Granger causality analysis on the resting-state functional magnetic resonance imaging data of 70 participants. Results showed that extraversion was positively correlated with the influence from the right inferior occipital gyrus (IOG) to the left amygdala, and from the bilateral IOG to the right amygdala; such result may represent the neural correlates of social interactions in extraverts. Conversely, neuroticism was associated with an increased influence from right amygdala to right middle frontal gyrus and a decreased influence from right precuneus to right amygdala. This influence might affect the modulations of cognitive regulation function and self-referential processes in neurotic individuals. These findings highlight the importance of the causal influences of amygdala in explaining the individual differences in extraversion and neuroticism, and offer further insights into the specific neural networks underlying personality.
authors.affiliation: Center for Information in BioMedicine, Key laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
authors.forename: Yajing
authors.initials: Y
authors.lastname: Pang
authors.affiliation: School of Political Science and Public Administration, University of Electronic Science and Technology of China, Chengdu, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Cui
authors.affiliation: Center for Information in BioMedicine, Key laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Center for Information in BioMedicine, Key laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
authors.forename: Yuyan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Center for Information in BioMedicine, Key laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
authors.forename: Xiaona
authors.initials: X
authors.lastname: Wang
authors.affiliation: Center for Information in BioMedicine, Key laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
authors.forename: Shaoqiang
authors.initials: S
authors.lastname: Han
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
authors.forename: Guangming
authors.initials: G
authors.lastname: Lu
authors.affiliation: Center for Information in BioMedicine, Key laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
authors.forename: Huafu
authors.initials: H
authors.lastname: Chen
mesh_terms: D000328:Adult; D000679:Amygdala / Q000502:physiology*; D001921:Brain / Q000000981:diagnostic imaging*; D001931:Brain Mapping; D003071:Cognition; D004644:Emotions / Q000502:physiology; D005120:Extraversion, Psychological; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net; D009434:Neural Pathways; D000075384:Neuroticism; D009778:Occipital Lobe / Q000000981:diagnostic imaging; D011795:Surveys and Questionnaires; D055815:Young Adult