title: The Impact of Mean Arterial Pressure on Functional Outcome Post Trauma-Related Acute Spinal Cord Injury: A Scoping Systematic Review of the Human Literature.
abstract: OBJECTIVE
  To perform a scoping systematic review on the literature surrounding mean arterial pressure (MAP) and functional outcomes post traumatic acute spinal cord injury (ASCI).
  
  
  METHODS
  We performed a systematic review of the literature via searching MEDLINE, BIOSIS, EMBASE, Global Health, SCOPUS, and Cochrane Library from inception to January 2015. We also performed a handsearch of various published meeting proceedings. Through a 2-step review process, employing 2 independent reviewers, we selected articles for the final review based on predefined inclusion/exclusion criteria.
  
  
  RESULTS
  Nine studies were included in the final review. Only 2 were prospective studies. All studies documented some degree of objective functional outcome in relation to MAP posttraumatic ASCI. Four studies documented a relation between higher MAP and improved functional outcome. Five studies failed to show any relationship between MAP and functional outcome.
  
  
  CONCLUSIONS
  Although no definitive conclusions could be reached based on the data collected, this study does give valuable insight into future avenues of research on the topic of hemodynamic management in traumatic ASCI as well as provides guidelines for refinement of future study design.
authors.affiliation: 1 Section of Neurosurgery, Department of Surgery, University of Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: Behzad
authors.initials: B
authors.lastname: Sabit
authors.affiliation: 1 Section of Neurosurgery, Department of Surgery, University of Manitoba, Winnipeg, Manitoba, Canada.|2 Clinician Investigator Program, University of Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: Frederick Adam
authors.initials: FA
authors.lastname: Zeiler
authors.affiliation: 1 Section of Neurosurgery, Department of Surgery, University of Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: Neil
authors.initials: N
authors.lastname: Berrington
mesh_terms: D000208:Acute Disease; D062186:Arterial Pressure; D019468:Disease Management; D006801:Humans; D017063:Outcome Assessment, Health Care; D013119:Spinal Cord Injuries / Q000503:physiopathology* / Q000628:therapy
keywords: acute spinal cord injury; blood pressure; cord injury; functional outcome; mean pressure