title: The Inflammatory Role of Platelets: Translational Insights from Experimental Studies of Autoimmune Disorders.
abstract: Beyond their indispensable role in hemostasis, platelets have shown to affect the development of inflammatory disorders, as they have been epidemiologically and mechanistically linked to diseases featuring an inflammatory reaction in inflammatory diseases like multiple sclerosis, rheumatoid arthritis and inflammatory bowel disorders. The identification of novel molecular mechanisms linking inflammation and to platelets has highlighted them as new targets for therapeutic interventions. In particular, genetic and pharmacological studies have identified an important role for platelets in neuroinflammation. This review summarizes the main molecular links between platelets and inflammation, focusing on immune regulatory factors, receptors, cellular targets and signaling pathways by which they can amplify inflammatory reactions and that make them potential therapeutic targets.
authors.affiliation: Department of Neurology, University of Münster, 48149 Münster, Germany. susann.pankratz@ukmuenster.de.
authors.forename: Susann
authors.initials: S
authors.lastname: Pankratz
authors.affiliation: Department of Neurology, University Medical Center of the Johannes Gutenberg-University, 55131 Mainz, Germany. stefan.bittner@unimedizin-mainz.de.
authors.forename: Stefan
authors.initials: S
authors.lastname: Bittner
authors.affiliation: Department of Anesthesiology, Intensive Care and Pain Medicine, Experimental and Clinical Hemostasis, University of Münster, 48149 Münster, Germany. haemostasis.research@uni-muenster.de.
authors.forename: Beate E
authors.initials: BE
authors.lastname: Kehrel
authors.affiliation: University Clinic for Cardiology and Cardiovascular Medicine, Eberhard Karls-University Tübingen, 72076 Tübingen, Germany. Harald.Langer@med.uni-tuebingen.de.|Section for Cardioimmunology, Eberhard Karls-University Tübingen, 72076 Tübingen, Germany. Harald.Langer@med.uni-tuebingen.de.
authors.forename: Harald F
authors.initials: HF
authors.lastname: Langer
authors.affiliation: Department of Neurology, University Hospital Essen, 45147 Essen, Germany. Christoph.Kleinschnitz@uk-essen.de.
authors.forename: Christoph
authors.initials: C
authors.lastname: Kleinschnitz
authors.affiliation: Department of Neurology, University of Münster, 48149 Münster, Germany. sven.meuth@ukmuenster.de.
authors.forename: Sven G
authors.initials: SG
authors.lastname: Meuth
authors.affiliation: Department of Neurology, University of Münster, 48149 Münster, Germany. kerstin.goebel@ukmuenster.de.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Göbel
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000473:pathology; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D001792:Blood Platelets / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000473:pathology; D015212:Inflammatory Bowel Diseases / Q000276:immunology / Q000473:pathology; D009103:Multiple Sclerosis / Q000276:immunology / Q000473:pathology
keywords: autoimmunity; neuroinflammation; platelets