title: Impact of selective LDL apheresis on serum chemerin levels in patients with hypercholesterolemia.
abstract: BACKGROUND
  Selective low-density lipoprotein (LDL) apheresis is commonly used to treat patients with familial hypercholesterolemia (FH). Chemerin is an adipokine with putative roles in the regulation of lipid metabolism.
  
  
  METHODS
  In our pilot study, we measured serum chemerin levels by enzyme-linked immunosorbent assay in six severe heterozygous FH patients before and after their first LDL apheresis treatments using the technique of direct adsorption of lipoproteins (DALI).
  
  
  RESULTS
  The first treatment sessions decreased serum chemerin levels by an average of 27.26 %. While following one patient, 12 months of regular LDL apheresis resulted in a permanent reduction in his serum chemerin level. Changes in the lipoprotein subfractions measured by gel electrophoresis (Lipoprint) correlated with the reduction of chemerin levels. Furthermore, we eluted and then measured chemerin bound to the DALI column.
  
  
  CONCLUSIONS
  We conclude that LDL apheresis decreases the circulating level of chemerin by binding the protein to the column and thus improves lipoprotein subfraction pattern.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, H-4032, Debrecen, Hungary.
authors.forename: Viktória E
authors.initials: VE
authors.lastname: Varga
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, H-4032, Debrecen, Hungary.
authors.forename: Hajnalka
authors.initials: H
authors.lastname: Lőrincz
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, H-4032, Debrecen, Hungary.
authors.forename: Noémi
authors.initials: N
authors.lastname: Zsíros
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, H-4032, Debrecen, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Fülöp
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, H-4032, Debrecen, Hungary.
authors.forename: Ildikó
authors.initials: I
authors.lastname: Seres
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, H-4032, Debrecen, Hungary.
authors.forename: György
authors.initials: G
authors.lastname: Paragh
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, H-4032, Debrecen, Hungary.
authors.forename: József
authors.initials: J
authors.lastname: Balla
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, H-4032, Debrecen, Hungary. mharangi@hotmail.com.
authors.forename: Mariann
authors.initials: M
authors.lastname: Harangi
mesh_terms: D000327:Adsorption; D000368:Aged; D001781:Blood Component Removal / Q000379:methods*; D018925:Chemokines / Q000097:blood*; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D050356:Lipid Metabolism / Q000235:genetics; D008077:Lipoproteins, LDL / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged
chemical_list: D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; D008077:Lipoproteins, LDL; C478630:RARRES2 protein, human
keywords: Chemerin; Familial hypercholesterolemia; HDL subfractions; LDL apheresis; LDL subfractions