title: The pathological features of idiopathic interstitial pneumonia-associated pulmonary adenocarcinomas.
abstract: OBJECTIVE
  To investigate the pathological features of idiopathic interstitial pneumonia (IIP)-associated pulmonary adenocarcinoma.
  
  
  RESULTS
  Surgically resected adenocarcinomas associated with IIP (the IIP group) and adenocarcinomas without IIP (the non-IIP group) were subjected to analysis. Adenocarcinomas in the IIP group were subdivided into two groups: one group included tumours connected to bronchiolar metaplasia in honeycomb lesions (the H-IIP group), and the other included tumours unrelated to honeycomb lesions (the NH-IIP group). Histomorphological appearance and immunohistochemical expression were compared among the H-IIP group, the NH-IIP group, and the non-IIP group. Most of the tumour cells in the H-IIP group had a tall, columnar shape that showed similar features to proximal bronchial epithelium, whereas tumour cells in the NH-IIP group and the non-IIP group had a club-like shape that showed similar features to respiratory bronchiolar/alveolar epithelium. Adenocarcinomas in the H-IIP group tended to be negative for thyroid transcription factor-1 (TTF-1) and positive for hepatocyte nuclear factor-4α (HNF-4α). The frequency of EGFR mutations was significantly lower in adenocarcinomas in the H-IIP group, although the frequencies of KRAS and ALK mutations did not differ among the three groups.
  
  
  CONCLUSIONS
  Idiopathic interstitial pneumonia-associated pulmonary adenocarcinomas, especially those arising from honeycomb lesions, have distinct pathological features.
authors.affiliation: Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.|Department of Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors.forename: Yoko
authors.identifier: http://orcid.org/0000-0001-9814-2282
authors.initials: Y
authors.lastname: Kojima
authors.affiliation: Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.|Division of Pathology, Kanagawa Cardiovascular and Respiratory Centre, Yokohama, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Okudela
authors.affiliation: Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors.forename: Mai
authors.initials: M
authors.lastname: Matsumura
authors.affiliation: Division of General Thoracic Surgery, Kanagawa Cardiovascular and Respiratory Centre, Yokohama, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Omori
authors.affiliation: Division of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Centre, Yokohama, Japan.
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Baba
authors.affiliation: Division of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Centre, Yokohama, Japan.
authors.forename: Akimasa
authors.initials: A
authors.lastname: Sekine
authors.affiliation: Department of Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors.forename: Tetsukan
authors.initials: T
authors.lastname: Woo
authors.affiliation: Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.|Division of Pathology, Kanagawa Cardiovascular and Respiratory Centre, Yokohama, Japan.
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Umeda
authors.affiliation: Division of Pathology, Japanese Red Cross Medical Centre Hospital, Tokyo, Japan.
authors.forename: Tamiko
authors.initials: T
authors.lastname: Takemura
authors.affiliation: Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Mitsui
authors.affiliation: Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors.forename: Takehisa
authors.initials: T
authors.lastname: Suzuki
authors.affiliation: Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Tateishi
authors.affiliation: Division of Radiology, Kanagawa Cardiovascular and Respiratory Centre, Yokohama, Japan.
authors.forename: Tae
authors.initials: T
authors.lastname: Iwasawa
authors.affiliation: Division of General Thoracic Surgery, Kanagawa Cardiovascular and Respiratory Centre, Yokohama, Japan.
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Arai
authors.affiliation: Division of General Thoracic Surgery, Kanagawa Cardiovascular and Respiratory Centre, Yokohama, Japan.
authors.forename: Michihiko
authors.initials: M
authors.lastname: Tajiri
authors.affiliation: Division of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Centre, Yokohama, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ogura
authors.affiliation: Division of Pathology, Kanagawa Cardiovascular and Respiratory Centre, Yokohama, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Kameda
authors.affiliation: Department of Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors.forename: Munetaka
authors.initials: M
authors.lastname: Masuda
authors.affiliation: Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors.forename: Kenich
authors.initials: K
authors.lastname: Ohashi
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000473:pathology*; D000368:Aged; D000369:Aged, 80 and over; D004252:DNA Mutational Analysis; D018572:Disease-Free Survival; D066246:ErbB Receptors / Q000235:genetics; D005260:Female; D006801:Humans; D054988:Idiopathic Interstitial Pneumonias / Q000150:complications*; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics
chemical_list: C117307:KRAS protein, human; C512478:EGFR protein, human; D066246:ErbB Receptors; D016283:Proto-Oncogene Proteins p21(ras)
keywords: histomorphological feature; idiopathic interstitial pneumonia; pulmonary adenocarcinoma