title: Effect of Balloon Pulmonary Angioplasty on Respiratory Function in Patients With Chronic Thromboembolic Pulmonary Hypertension.
abstract: Balloon pulmonary angioplasty (BPA) in chronic thromboembolic pulmonary hypertension (CTEPH) improves hemodynamics and exercise capacity. However, its effect on respiratory function is unclear. Our objective was to investigate the effect of BPA on respiratory function.
  
  
  
  We enrolled patients with inoperable CTEPH who underwent BPA primarily in lower lobe arteries (first series) and upper and middle lobe arteries (second series). We compared changes in hemodynamics and respiratory function between different BPA fields.
  
  
  
  Sixty-two BPA sessions were performed in 13 consecutive patients. Mean pulmonary arterial pressure and pulmonary vascular resistance significantly improved from 44 ± 8 to 23 ± 5 mm Hg and 818 ± 383 to 311 ± 117 dyne/s/cm-5. The percent predicted diffusion capacity of lung for carbon monoxide (Dlco) decreased after BPA in the lower lung field (from 60% ± 8% to 54% ± 8%) with no recovery. Percent Dlco increased after BPA in the upper middle lung field (from 53% ± 6% to 58% ± 6%) and continued to improve during the follow-up (from 58% ± 6% to 64% ± 11%). The ventilation/Co2production (V˙e/V˙co2) slope significantly improved after BPA in the lower lung field (from 51 ± 13 to 41 ± 8) and continued to improve during the follow-up (from 41 ± 8 to 35 ± 7); however, the V˙e/V˙co2slope remained unchanged after BPA in the upper/middle lung field. Changes in % Dlco and the V˙e/V˙co2slope differed significantly between lower and upper/middle lung fields.
  
  
  
  The effect of BPA on respiratory function in patients with CTEPH differed depending on the lung field.
authors.affiliation: Department of Rehabilitation, Tokyo Women's Medical University, Tokyo, Japan; Department of Internal Medicine and Rehabilitation, Science Disability Science, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address: pt13.12130023@gmail.com.
authors.forename: Mina
authors.initials: M
authors.lastname: Akizuki
authors.affiliation: Department of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Serizawa
authors.affiliation: Department of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Ueno
authors.affiliation: Department of Rehabilitation, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Taku
authors.initials: T
authors.lastname: Adachi
authors.affiliation: Department of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Hagiwara
mesh_terms: D000368:Aged; D000800:Angioplasty, Balloon; D002248:Carbon Monoxide; D002908:Chronic Disease; D015331:Cohort Studies; D005080:Exercise Test; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D011446:Prospective Studies; D011651:Pulmonary Artery / Q000601:surgery*; D011653:Pulmonary Diffusing Capacity; D011655:Pulmonary Embolism / Q000150:complications; D012123:Pulmonary Ventilation; D016896:Treatment Outcome; D014655:Vascular Resistance; D000070857:Walk Test
chemical_list: D002248:Carbon Monoxide
keywords: balloon pulmonary angioplasty; chronic thromboembolic pulmonary hypertension; respiratory function