title: Serum inhibin and leptin: Risk factors for pre-eclampsia?
abstract: BACKGROUND
  Pre-eclampsia and eclampsia are parts of the broader spectrum of hypertensive disorders complicating pregnancy. This study aims to examine the association between serum inhibin and leptin levels and pre-eclampsia.
  
  
  METHODS
  This study included 98 consecutive cases of pregnant women with pre-eclampsia, together with their 98 pregnant controls, matched for age, gestational week and time period of delivery. Maternal venous blood samples were obtained within 24h before delivery. In addition to serum inhibin and leptin, birth order, multiple pregnancy, maternal age, maternal overweight/obesity, maternal education, maternal smoking and family history of diabetes/hypertension, were examined as risk factors. Multivariate logistic regression analysis was performed.
  
  
  RESULTS
  At the univariate analysis, serum inhibin and leptin levels were significantly higher in cases vs.
  
  
  METHODS
  Pre-eclampsia occurred more frequently in primiparous women, whereas overweight and obesity were also associated with pre-eclampsia. At the multivariate analysis, higher serum inhibin levels were associated with pre-eclampsia (multivariate OR=1.09, 95%CI: 1.03-1.17, p=0.004, increase per 0.1ng/mL). On the other hand, leptin was not independently associated with the occurrence of pre-eclampsia (multivariate OR=1.02, 95%CI: 0.95-1.09, p=0.631, increase per 10ng/mL).
  
  
  CONCLUSIONS
  Elevated serum inhibin levels seem to be associated with pre-eclampsia, reflecting placental dysfunction. Increased serum leptin levels may merely reflect an elevated maternal body mass index, which is a well-known risk factor for pre-eclampsia.
authors.affiliation: Third Department of Obstetrics and Gynecology, General Hospital "Attikon", Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Chrelias
authors.affiliation: Third Department of Obstetrics and Gynecology, General Hospital "Attikon", Medical School, National and Kapodistrian University of Athens, Athens, Greece. Electronic address: makrismg@hotmail.com.
authors.forename: Georgios-Marios
authors.initials: GM
authors.lastname: Makris
authors.affiliation: Third Department of Obstetrics and Gynecology, General Hospital "Attikon", Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Aristea-Maria
authors.initials: AM
authors.lastname: Papanota
authors.affiliation: Department of Cytopathology, General Hospital "Attikon", Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Aris
authors.initials: A
authors.lastname: Spathis
authors.affiliation: Third Department of Obstetrics and Gynecology, General Hospital "Attikon", Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Salamalekis
authors.affiliation: Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Theodoros N
authors.initials: TN
authors.lastname: Sergentanis
authors.affiliation: Hormonal and Biochemical Laboratory, Aretaieio Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Demetrios
authors.initials: D
authors.lastname: Rizos
authors.affiliation: Department of Cytopathology, General Hospital "Attikon", Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Petros
authors.initials: P
authors.lastname: Karakitsos
authors.affiliation: Third Department of Obstetrics and Gynecology, General Hospital "Attikon", Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Charalampos
authors.initials: C
authors.lastname: Chrelias
mesh_terms: D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007265:Inhibins / Q000097:blood*; D020738:Leptin / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis; D011247:Pregnancy; D012307:Risk Factors
chemical_list: D020738:Leptin; D007265:Inhibins
keywords: Birth order; Diabetes mellitus; Inhibin; Leptin; Obesity; Pre-eclampsia