title: Penconazole alters redox status, cholinergic function, and membrane-bound ATPases in the cerebrum and cerebellum of adult rats.
abstract: Pesticides exposure causes usually harmful effects to the environment and human health. The present study aimed to investigate the potential toxic effects of penconazole, a triazole fungicide, on the cerebrum and cerebellum of adult rats. Penconazole was administered intraperitoneally to male Wistar rats at a dose of 67 mg kg-1body weight every 2 days during 9 days. Results showed that penconazole induced oxidative stress in rat cerebrum and cerebellum tissues. In fact, we have found a significant increase in malondialdehyde, hydrogen peroxide, and advanced oxidation protein product levels, as well as an alteration of the antioxidant status, enzymatic (superoxide dismutase and catalase) and nonenzymatic (glutathione), the cholinergic function, and membrane-bound ATPases (Na+/K+-ATPase and Mg2+-ATPase). Penconazole also provoked histological alterations marked by pyknotic and vacuolated neurons in the cerebrum and apoptosis and edema in the cerebellum Purkinje cells' layer. Therefore, the use of this neurotoxicant fungicide must be regularly monitored in the environment.
authors.affiliation: 1 Animal Physiology Laboratory, Department of Life Sciences, Sciences Faculty, University of Sfax, Tunisia.|2 Enzymes and Bioconversion Unit, National Engineering School of Sfax, University of Sfax, Tunisia.
authors.forename: M
authors.initials: M
authors.lastname: Chaâbane
authors.affiliation: 1 Animal Physiology Laboratory, Department of Life Sciences, Sciences Faculty, University of Sfax, Tunisia.
authors.forename: I
authors.initials: I
authors.lastname: Ghorbel
authors.affiliation: 1 Animal Physiology Laboratory, Department of Life Sciences, Sciences Faculty, University of Sfax, Tunisia.
authors.forename: A
authors.initials: A
authors.lastname: Elwej
authors.affiliation: 3 Histopathology Laboratory, University of Sfax, CHU Habib Bourguiba, Sfax, Tunisia.
authors.forename: H
authors.initials: H
authors.lastname: Mnif
authors.affiliation: 3 Histopathology Laboratory, University of Sfax, CHU Habib Bourguiba, Sfax, Tunisia.
authors.forename: T
authors.initials: T
authors.lastname: Boudawara
authors.affiliation: 2 Enzymes and Bioconversion Unit, National Engineering School of Sfax, University of Sfax, Tunisia.
authors.forename: S Ellouze
authors.initials: SE
authors.lastname: Chaâbouni
authors.affiliation: 1 Animal Physiology Laboratory, Department of Life Sciences, Sciences Faculty, University of Sfax, Tunisia.
authors.forename: N
authors.initials: N
authors.lastname: Zeghal
authors.affiliation: 1 Animal Physiology Laboratory, Department of Life Sciences, Sciences Faculty, University of Sfax, Tunisia.
authors.forename: N
authors.initials: N
authors.lastname: Soudani
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000251:Adenosine Triphosphatases / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002462:Cell Membrane / Q000201:enzymology; D002531:Cerebellum / Q000201:enzymology*; D054022:Cerebrum / Q000201:enzymology*; D005659:Fungicides, Industrial / Q000494:pharmacology; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D006861:Hydrogen Peroxide; D015227:Lipid Peroxidation; D008297:Male; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000235:genetics / Q000378:metabolism*; D014230:Triazoles / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D005659:Fungicides, Industrial; D014230:Triazoles; C087058:penconazole; D006861:Hydrogen Peroxide; D000251:Adenosine Triphosphatases; C035123:magnesium sodium ATPase; D000254:Sodium-Potassium-Exchanging ATPase; D000109:Acetylcholine
keywords: Penconazole; cerebellum; cerebrum; cholinergic function; membrane-bound ATPases; oxidative stress; rats