title: Prospective randomized controlled study on the validity and safety of an absorbable adhesion barrier (Interceed®) made of oxidized regenerated cellulose for laparoscopic colorectal surgery.
abstract: BACKGROUND
  Clinical use of an adhesion barrier made of oxidized, regenerated cellulose, Interceed®, has been reported in the field of obstetrics and gynecology to help prevent adhesions between the peritoneum and the bowel in various types of operations. In gastrointestinal surgery, sodium hyaluronate/carboxymethylcellulose has been reported as an absorbable membrane to reduce postoperative adhesions. The present study was a prospective randomized controlled study to investigate the safety and usefulness of Interceed in laparoscopic colorectal surgery.
  
  
  METHODS
  We analyzed 99 patients who underwent laparoscopic colorectal surgery from 2013 to 2014. The patients were randomly allocated to the group that used Interceed (Interceed group) or the group that did not (Non-Interceed group).
  
  
  RESULTS
  Fifty cases used Interceed, and 49 cases did not. The incidence of adverse events was 12.0% in the Interceed group and 16.3% in the Non-Interceed group (P = 0.58). There were no significant differences, and no adhesive bowel obstructions were observed in the Interceed group.
  
  
  CONCLUSIONS
  We have shown that using Interceed in laparoscopic colorectal surgery is valid and technically safe.
authors.affiliation: Department of Surgery, Kitasato University School of Medicine, Sagamihara, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Naito
authors.affiliation: Department of Surgery, Kitasato University School of Medicine, Sagamihara, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Ogura
authors.affiliation: Department of Surgery, Kitasato University School of Medicine, Sagamihara, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yamanashi
authors.affiliation: Department of Surgery, Kitasato University School of Medicine, Sagamihara, Japan.
authors.forename: Takeo
authors.initials: T
authors.lastname: Sato
authors.affiliation: Department of Surgery, Kitasato University School of Medicine, Sagamihara, Japan.
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Nakamura
authors.affiliation: Department of Surgery, Kitasato University School of Medicine, Sagamihara, Japan.
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Miura
authors.affiliation: Department of Surgery, Kitasato University School of Medicine, Sagamihara, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Tsutsui
authors.affiliation: Clinical Research Center, Kitasato University School of Medicine, Sagamihara, Japan.
authors.forename: Yasutoshi
authors.initials: Y
authors.lastname: Sakamoto
authors.affiliation: Clinical Research Center, Kitasato University School of Medicine, Sagamihara, Japan.
authors.forename: Rieko
authors.initials: R
authors.lastname: Tanaka
authors.affiliation: Clinical Research Center, Kitasato University School of Medicine, Sagamihara, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kumagai
authors.affiliation: Department of Surgery, Kitasato University School of Medicine, Sagamihara, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Watanabe
mesh_terms: D000368:Aged; D002483:Cellulose, Oxidized; D003106:Colon / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007410:Intestinal Diseases / Q000209:etiology / Q000517:prevention & control*; D010535:Laparoscopy / Q000295:instrumentation*; D008297:Male; D008875:Middle Aged; D061214:Patient Safety; D010532:Peritoneal Diseases / Q000209:etiology / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D012007:Rectum / Q000601:surgery*; D015203:Reproducibility of Results; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control; D016896:Treatment Outcome
chemical_list: D002483:Cellulose, Oxidized; C060002:INTERCEED
keywords: Adhesion barrier; laparoscopic colorectal surgery; oxidized regenerated cellulose