title: Paliperidone Palmitate Treatment in Outpatient Care Setting: A Naturalistic Study.
abstract: To evaluate paliperidone palmitate (PP) effectiveness, safety and adherence to treatment.
  We collected data of all patients (n = 50) affected by Schizophrenia Disorders, treated with PP for a 3 month minimum period in the outpatient setting of Mental Health Department in Modena, from 01/01/2014 to 31/01/2015. We evaluated reasons and modality for PP implementation, improvement in symptom and functioning scales, adverse effects, discontinuations and relapses. We statistically correlated socio-demographic and clinical variables of our sample with PP therapeutic variables.
  We registered an improvement in all scales, with a superior percentage in PANSS positive subscale. The mean PP dose in some patients was lower than official indications, although our sample was clinically severe. Illness relapses affected 60% and dropout 18% of patients. PP was well tolerated and in just a few cases adverse events required treatment interruption. The risk factors for discontinuation were represented by "lack of therapeutic compliance" (HR = 4.11, p < 0.0001) and "inefficacy" (HR = 1.67, p < 0.0001).
  With limitations of observational design, this research highlights that PP was well tolerated and effective in improving both psychotic symptoms and functioning, but moderately effective in preventing relapse, probably due to clinical severity of our patients associated with extremely cautious and flexible PP prescriptions.
authors.affiliation: Dr. Di Lorenzo, MD, Psychiatrist, SPDC c/o NOCSAE, via P. Giardini, 1355, 41126 Baggiovara (Modena), Mental Health Department, Az-Usl, Modena, Italy. Dr. Cameli, MD, Psychiatrist, Private accredited psychiatric hospital, Villa Maria Luigia, via Montepelato Nord, 41, 43022 Monticelli Terme (PR), Italy. Drs. Bolondi, MD, Landi, MD, Piemonte, MD, Pollutri, MD, Residents in Psychiatry, University of Modena and Reggio Emilia, via del Pozzo, 71, 41224 Modena, Italy. Dr. Moretti, MD, Psychiatrist, Centro Salute Mentale, via Mandriolo Superiore, 11, 42015 Correggio, AzUsl Reggio Emilia, Italy.
authors.forename: Rosaria
authors.initials: R
authors.lastname: Di Lorenzo
authors.affiliation: Dr. Di Lorenzo, MD, Psychiatrist, SPDC c/o NOCSAE, via P. Giardini, 1355, 41126 Baggiovara (Modena), Mental Health Department, Az-Usl, Modena, Italy. Dr. Cameli, MD, Psychiatrist, Private accredited psychiatric hospital, Villa Maria Luigia, via Montepelato Nord, 41, 43022 Monticelli Terme (PR), Italy. Drs. Bolondi, MD, Landi, MD, Piemonte, MD, Pollutri, MD, Residents in Psychiatry, University of Modena and Reggio Emilia, via del Pozzo, 71, 41224 Modena, Italy. Dr. Moretti, MD, Psychiatrist, Centro Salute Mentale, via Mandriolo Superiore, 11, 42015 Correggio, AzUsl Reggio Emilia, Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Cameli
authors.affiliation: Dr. Di Lorenzo, MD, Psychiatrist, SPDC c/o NOCSAE, via P. Giardini, 1355, 41126 Baggiovara (Modena), Mental Health Department, Az-Usl, Modena, Italy. Dr. Cameli, MD, Psychiatrist, Private accredited psychiatric hospital, Villa Maria Luigia, via Montepelato Nord, 41, 43022 Monticelli Terme (PR), Italy. Drs. Bolondi, MD, Landi, MD, Piemonte, MD, Pollutri, MD, Residents in Psychiatry, University of Modena and Reggio Emilia, via del Pozzo, 71, 41224 Modena, Italy. Dr. Moretti, MD, Psychiatrist, Centro Salute Mentale, via Mandriolo Superiore, 11, 42015 Correggio, AzUsl Reggio Emilia, Italy.
authors.forename: Marisa
authors.initials: M
authors.lastname: Bolondi
authors.affiliation: Dr. Di Lorenzo, MD, Psychiatrist, SPDC c/o NOCSAE, via P. Giardini, 1355, 41126 Baggiovara (Modena), Mental Health Department, Az-Usl, Modena, Italy. Dr. Cameli, MD, Psychiatrist, Private accredited psychiatric hospital, Villa Maria Luigia, via Montepelato Nord, 41, 43022 Monticelli Terme (PR), Italy. Drs. Bolondi, MD, Landi, MD, Piemonte, MD, Pollutri, MD, Residents in Psychiatry, University of Modena and Reggio Emilia, via del Pozzo, 71, 41224 Modena, Italy. Dr. Moretti, MD, Psychiatrist, Centro Salute Mentale, via Mandriolo Superiore, 11, 42015 Correggio, AzUsl Reggio Emilia, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Landi
authors.affiliation: Dr. Di Lorenzo, MD, Psychiatrist, SPDC c/o NOCSAE, via P. Giardini, 1355, 41126 Baggiovara (Modena), Mental Health Department, Az-Usl, Modena, Italy. Dr. Cameli, MD, Psychiatrist, Private accredited psychiatric hospital, Villa Maria Luigia, via Montepelato Nord, 41, 43022 Monticelli Terme (PR), Italy. Drs. Bolondi, MD, Landi, MD, Piemonte, MD, Pollutri, MD, Residents in Psychiatry, University of Modena and Reggio Emilia, via del Pozzo, 71, 41224 Modena, Italy. Dr. Moretti, MD, Psychiatrist, Centro Salute Mentale, via Mandriolo Superiore, 11, 42015 Correggio, AzUsl Reggio Emilia, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Moretti
authors.affiliation: Dr. Di Lorenzo, MD, Psychiatrist, SPDC c/o NOCSAE, via P. Giardini, 1355, 41126 Baggiovara (Modena), Mental Health Department, Az-Usl, Modena, Italy. Dr. Cameli, MD, Psychiatrist, Private accredited psychiatric hospital, Villa Maria Luigia, via Montepelato Nord, 41, 43022 Monticelli Terme (PR), Italy. Drs. Bolondi, MD, Landi, MD, Piemonte, MD, Pollutri, MD, Residents in Psychiatry, University of Modena and Reggio Emilia, via del Pozzo, 71, 41224 Modena, Italy. Dr. Moretti, MD, Psychiatrist, Centro Salute Mentale, via Mandriolo Superiore, 11, 42015 Correggio, AzUsl Reggio Emilia, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Piemonte
authors.affiliation: Dr. Di Lorenzo, MD, Psychiatrist, SPDC c/o NOCSAE, via P. Giardini, 1355, 41126 Baggiovara (Modena), Mental Health Department, Az-Usl, Modena, Italy. Dr. Cameli, MD, Psychiatrist, Private accredited psychiatric hospital, Villa Maria Luigia, via Montepelato Nord, 41, 43022 Monticelli Terme (PR), Italy. Drs. Bolondi, MD, Landi, MD, Piemonte, MD, Pollutri, MD, Residents in Psychiatry, University of Modena and Reggio Emilia, via del Pozzo, 71, 41224 Modena, Italy. Dr. Moretti, MD, Psychiatrist, Centro Salute Mentale, via Mandriolo Superiore, 11, 42015 Correggio, AzUsl Reggio Emilia, Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Pollutri
keywords: effectiveness and safety; outpatient care setting; paliperidone palmitate treatment; relapse and adverse effects