title: Genetic evolution in chronic lymphocytic leukaemia.
abstract: Next-generation sequencing provides a comprehensive understanding of the genomic, epigenomic and transcriptomic underpinnings of chronic lymphocytic leukaemia. Recent studies have uncovered new drivers, including mutations in non-coding regions, and signalling pathways whose role in cancer was previously unknown or poorly understood. Moreover, massive scale epigenomics and transcriptomics have supplied the foundations for the cellular origin of the disease. Some drivers could be targeted pharmacologically, and the ability to detect mutations present in minority subclones might even allow treatment before clonal selection occurs, thus preventing disease refractoriness. As our understanding broadens and ongoing technological innovation propels new achievements, we will certainly learn how to apply it in our daily practice.
authors.affiliation: Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Calle Roselló 149-153, 08036 Barcelona, Spain; Department of Haematology, Hospital Clínic, Calle Villarroel 170, 08036 Barcelona, Spain. Electronic address: jdelgado@clinic.ub.es.
authors.forename: Julio
authors.initials: J
authors.lastname: Delgado
authors.affiliation: Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Calle Roselló 149-153, 08036 Barcelona, Spain; Haematopathology Unit, Hospital Clínic, Calle Villarroel 170, 08036 Barcelona, Spain.
authors.forename: Neus
authors.initials: N
authors.lastname: Villamor
authors.affiliation: Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Calle Roselló 149-153, 08036 Barcelona, Spain; Department of Haematology, Hospital Clínic, Calle Villarroel 170, 08036 Barcelona, Spain; Universitat de Barcelona, Facultat de Medicina, Calle Casanova 143, 08036 Barcelona, Spain.
authors.forename: Armando
authors.initials: A
authors.lastname: López-Guillermo
authors.affiliation: Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Calle Roselló 149-153, 08036 Barcelona, Spain; Haematopathology Unit, Hospital Clínic, Calle Villarroel 170, 08036 Barcelona, Spain; Universitat de Barcelona, Facultat de Medicina, Calle Casanova 143, 08036 Barcelona, Spain.
authors.forename: Elías
authors.initials: E
authors.lastname: Campo
mesh_terms: D060965:Clonal Evolution / Q000235:genetics*; D044127:Epigenesis, Genetic; D057890:Epigenomics; D015973:Gene Expression Regulation, Leukemic; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000378:metabolism; D009154:Mutation; D015398:Signal Transduction / Q000235:genetics*
keywords: CLL; Clonal evolution; Epigenomics; Genomics; NGS; Non-coding