title: CDKN2BAS polymorphisms are associated with coronary heart disease risk a Han Chinese population.
abstract: The goal of our study was to determine whether CDKN2BAS polymorphisms are associated with coronary heart disease (CHD) risk in a Han Chinese population. Eight SNPs were genotyped in 676 men and 465 women. We used χ2 tests and genetic model analyses to evaluate associations between the SNPs and CHD risk. We found that rs10757274 was associated with an increased risk of CHD in both men (allele G: Odds ratio [OR] = 1.30, 95% confidence interval [CI]: 1.05-1.61, P = 0.018; codominant model: P = 0.042; recessive model: OR = 1.70, 95% CI: 1.10-2.62, P = 0.016; log-additive model: OR = 1.34, 95% CI: 1.05-1.71, P = 0.019) and women (dominant model: OR = 2.26, 95% CI: 1.28-3.99, P = 0.004). In addition, rs7865618 was associated with an 8.10-fold increased risk of CHD in women under a recessive model (OR = 8.10, 95% CI: 1.74-37.68, P = 0.006). Interestingly, the haplotype AA (rs10757274 and rs1333042) of CDKN2BAS was associated with decreased the risk of CHD in men (OR = 0.72, 95% CI: 0.55 - 0.95, P = 0.022).
authors.affiliation: Department of Geratology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Qingbin
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Cardiology, Xi'an Center Hospital, Xi'an, Shaanxi, China.
authors.forename: Shudan
authors.initials: S
authors.lastname: Liao
authors.affiliation: Department of Geratology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Huiyi
authors.initials: H
authors.lastname: Wei
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Liu
authors.affiliation: Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, Shaanxi, China.|Xi'an Tiangen Precision Medical Institute, Xi'an, Shaanxi, China.
authors.forename: Jingjie
authors.initials: J
authors.lastname: Li
authors.affiliation: Xi'an Tiangen Precision Medical Institute, Xi'an, Shaanxi, China.
authors.forename: Xiyang
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, Shaanxi, China.|Xi'an Tiangen Precision Medical Institute, Xi'an, Shaanxi, China.
authors.forename: Mengdan
authors.initials: M
authors.lastname: Yan
authors.affiliation: Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, Shaanxi, China.|Xi'an Tiangen Precision Medical Institute, Xi'an, Shaanxi, China.
authors.forename: Tianbo
authors.initials: T
authors.lastname: Jin
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China; D003327:Coronary Disease / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D065840:Protective Factors; D062085:RNA, Long Noncoding / Q000235:genetics*; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors
chemical_list: C561518:CDKN2B antisense RNA, human; D062085:RNA, Long Noncoding
keywords: CDKN2BAS; case-control,Gerotarget; coronary heart disease; single nucleotide polymorphisms