title: Intensive Care Management of Pediatric Acute Liver Failure.
abstract: Pediatric acute liver failure is rare but life-threatening illness that occurs in children without preexisting liver disease. The rarity of the disease, along with its severity and heterogeneity, presents unique clinical challenges to the physicians providing care for pediatric patients with acute liver failure. In this review, practical clinical approaches to the care of critically ill children with acute liver failure are discussed with an organ system-specific approach. The underlying pathophysiological processes, major areas of uncertainty, and approaches to the critical care management of pediatric acute liver failure are also reviewed.
authors.affiliation: *Section of Pediatric Critical Care †Section of Pediatric Gastroenterology, Hepatology and Nutrition, Riley Hospital for Children, Indiana University School of Medicine, Indiana University, Indianapolis.
authors.forename: Riad
authors.initials: R
authors.lastname: Lutfi
authors.forename: Kamal
authors.initials: K
authors.lastname: Abulebda
authors.forename: Mara E
authors.initials: ME
authors.lastname: Nitu
authors.forename: Jean P
authors.initials: JP
authors.lastname: Molleston
authors.forename: Molly A
authors.initials: MA
authors.lastname: Bozic
authors.forename: Girish
authors.initials: G
authors.lastname: Subbarao
mesh_terms: D002648:Child; D003131:Combined Modality Therapy; D003422:Critical Care / Q000379:methods*; D006801:Humans; D017114:Liver Failure, Acute / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D011379:Prognosis