title: Regulation and Immune Function of IL-27.
abstract: IL-27 is a pleiotropic cytokine that has diverse immune regulatory activities under both physiological and pathological conditions. IL-27 enhances the functions of Th1 and CD8+T cells, promotes the development of Tfh and Tr1, and suppresses the functions of Th2, Treg, Th9, and Th17 cells. IL-27 is also involved in regulation of immune responses of B cells, NK, DCs, and macrophages. IL-27 production is strictly regulated at both transcriptional and posttranscriptional levels. Given its broad effects on immune regulation, IL-27 has been implicated in the pathogeneses of autoimmune and infectious diseases as well as cancers. In this chapter, the biological characters of IL-27 have been reviewed, including the molecular mechanisms of IL-27 production and the underlying cellular signaling pathway. The regulatory effects of IL-27 on immune responses in autoimmune disease, infectious disease, and cancer are also discussed.
authors.affiliation: Division of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University School of Medicine, Doisy Research Center, Rm. 811 1100 S. Grand Blvd., St. Louis, MO, 63104, USA.
authors.forename: Qinghong
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Division of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University School of Medicine, Doisy Research Center, Rm. 811 1100 S. Grand Blvd., St. Louis, MO, 63104, USA. jliu9@slu.edu.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Liu
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D007239:Infections / Q000235:genetics / Q000276:immunology; D064094:Interleukin-27 / Q000235:genetics* / Q000378:metabolism*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism; D058504:Th17 Cells / Q000276:immunology / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology / Q000378:metabolism
chemical_list: D064094:Interleukin-27
keywords: Autoimmune diseases; Cancer; DC and macrophage; IL-27; Infectious diseases; Signaling pathway; T cell function