title: Surveillance of Transmitted Drug Resistance in HIV-1-Infected Youths Aged 16 to 25 Years, a Decade After Scale-up of Antiretroviral Therapy in Hebei, China.
abstract: Sexual exposure has been the predominant route of HIV-1 spread in Hebei Province, China. However, little information is available on HIV-1-transmitted drug resistance (TDR) among HIV-1-infected youths aged 16 to 25 years who are infected with HIV-1 and sexually active. In this study, the overall prevalence of TDR was 6.6% (10/152), a moderate level (5.0%-15.0%) according to World Health Organization Threshold Survey guidelines. However, the prevalence of TDR to protease inhibitors and nonnucleoside reverse transcriptase inhibitors was 4.6% (7/152) and 2.0% (3/152), respectively, which correspond to a low level (<5.0%). All TDR mutations (M46L/I, Y181C, K101E, and G190E) were found only in youths infected with HIV-1 through sexual activity. The prevalence of TDR among heterosexuals (10.0%, 3/30) was higher than that among men who have sex with men (5.8%, 7/120). TDR mutations resided in CRF01_AE (M46I/L and G190E) and subtype B (Y181C and K101E). Our findings will provide useful information on which drug regimens to use in treating the newly infected people with HIV-1.
authors.affiliation: 1 College of Life Science, Hebei University , Baoding, China .|2 Hebei Provincial Center for Disease Control and Prevention , Shijiazhuang, China .
authors.forename: Xinli
authors.initials: X
authors.lastname: Lu
authors.affiliation: 1 College of Life Science, Hebei University , Baoding, China .
authors.forename: Xianjiang
authors.initials: X
authors.lastname: Kang
authors.affiliation: 3 Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology , Beijing, China .
authors.forename: Yongjian
authors.initials: Y
authors.lastname: Liu
authors.affiliation: 2 Hebei Provincial Center for Disease Control and Prevention , Shijiazhuang, China .
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: 2 Hebei Provincial Center for Disease Control and Prevention , Shijiazhuang, China .
authors.forename: Suliang
authors.initials: S
authors.lastname: Chen
authors.affiliation: 3 Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology , Beijing, China .
authors.forename: Jingyun
authors.initials: J
authors.lastname: Li
authors.affiliation: 2 Hebei Provincial Center for Disease Control and Prevention , Shijiazhuang, China .
authors.forename: Ze
authors.initials: Z
authors.lastname: Cui
mesh_terms: D000293:Adolescent; D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D002681:China / Q000453:epidemiology; D024882:Drug Resistance, Viral; D062665:Epidemiological Monitoring; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000635:transmission* / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D015995:Prevalence; D055815:Young Adult
chemical_list: D044966:Anti-Retroviral Agents
keywords: HIV-1; mutation; subtype; transmitted drug resistance; youth