title: Blood Levels of Oxidant/Antioxidant Parameters in Rats Infected withToxoplasma gondii.
abstract: Toxoplasmosis is a common parasitic infection in the world. Since increased free radicals and oxidative stress are reported in many parasitic diseases the purpose of the present study was to evaluate the oxidative stress in acute and chronic toxoplasmosis. RH strains ofToxoplasmatachyzoites were used in the present study. Twenty-five female rats were infected with the parasite while 25 other rats were as the control group that received normal saline. Zero-, 5-, 7-, 10-, and 45-day postinfection (DPI) blood samples were taken. Some parameters related to oxidant and antioxidants such as antioxidant enzymes, malondialdehyde, and total antioxidant capacity were measured. On day 7 after infection, GPX activity and GSH level were significantly increased and in the mentioned day the amount of total antioxidant capacity was significantly reduced. In other cases, there were no significant differences between the groups in different days. Overall, based on the results it seems that, on day 7 after infection, in infected rats responses to oxidative stress were triggered and led to decrease of total antioxidant capacity. Furthermore, glutathione was increased to cope with stress. It seems that probably antioxidant defense system entered the infection to the chronic phase and changed the parasites stage.
authors.affiliation: Department of Parasitology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
authors.forename: Somayeh
authors.identifier: 0000-0002-2643-4494
authors.initials: S
authors.lastname: Bahrami
authors.affiliation: Department of Biochemistry, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Shahriari
authors.affiliation: Department of Medical Parasitology, Faculty of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Tavalla
authors.affiliation: Department of Parasitology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
authors.forename: Somayeh
authors.initials: S
authors.lastname: Azadmanesh
authors.affiliation: Department of Parasitology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Hamidinejat
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000097:blood; D005260:Female; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D008315:Malondialdehyde / Q000097:blood; D008807:Mice, Inbred BALB C; D016877:Oxidants / Q000097:blood*; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood; D014122:Toxoplasma / Q000502:physiology*; D014123:Toxoplasmosis / Q000097:blood* / Q000469:parasitology*
chemical_list: D000975:Antioxidants; D016877:Oxidants; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione