title: Cathepsins are potential therapeutic targets in kidney disease.
abstract: Cathepsins are a class of proteases with diverse biological activities inside and, in part, also outside cells. Recent studies suggest that cathepsins are involved in the pathogenesis of diabetic nephropathy and in disease activity of autoimmune immune complex glomerulonephritis. Targeting specific cathepsins with suitable antagonists may hold promises for therapeutic interventions.
authors.affiliation: Medizinische Klinik and Poliklinik IV, Klinikum der Ludwig Maximilians Universität München, Munich, Germany.
authors.forename: Santhosh
authors.initials: S
authors.lastname: Kumar Vr
authors.affiliation: Medizinische Klinik and Poliklinik IV, Klinikum der Ludwig Maximilians Universität München, Munich, Germany. Electronic address: hjanders@med.uni-muenchen.de.
authors.forename: Hans-Joachim
authors.initials: HJ
authors.lastname: Anders
mesh_terms: D056668:Cathepsin L; D002403:Cathepsins / Q000037:antagonists & inhibitors*; D003928:Diabetic Nephropathies; D006801:Humans
chemical_list: D002403:Cathepsins; D056668:Cathepsin L