title: Clinical Application of Autologous Adipose Stem Cells in Patients with Multiple Sclerosis: Preliminary Results.
abstract: The clinical outcome of autologous adipose stem cell (ASC) treatment of patients with multiple sclerosis (MS) was investigated following one year of observation.Methods. The clinical and MRI outcomes of 16 ASC-treated patients with RRMS and SPMS are reported after a one-year follow-up period.Results.At 18 months of follow-up, some patients showed "enticing" improvements on some exploratory efficacy measures, although a significant benefit was not observed for any measure across the entire group. Neither the progression of disability nor relapses were observed in any cases. In four patients, we found new gadolinium+ (Gd+) lesions on MRI. Our results indicate that ASC therapy is safe and does not produce any substantial side effects. Disease progression-free survival (PFS) of 18 months was seen in all patients with RRMS and SPMS. In these patients, EDSS scores did not progress above baseline scores. Gd-enhancing lesions were observed in two cases with RRMS, but these patients did not exhibit changes in EDSS score.Conclusion. Intrathecal treatment with ASCs is an attractive form of therapy for patients with MS but should be reserved for cases with aggressive disease progression, for cases that are still in the inflammatory phase, and for the malignant form.
authors.affiliation: Department of Neurology, Military Institute of Medicine, Warsaw, Poland.
authors.forename: Adam
authors.initials: A
authors.lastname: Stepien
authors.affiliation: Department of Neurology, Military Institute of Medicine, Warsaw, Poland.
authors.forename: Natalia L
authors.initials: NL
authors.lastname: Dabrowska
authors.affiliation: Department of Neurology, Military Institute of Medicine, Warsaw, Poland.
authors.forename: Marzena
authors.initials: M
authors.lastname: Maciagowska
authors.affiliation: Department of Neurology, Military Institute of Medicine, Warsaw, Poland.
authors.forename: Renata Piusinska
authors.identifier: 0000-0001-5127-9652
authors.initials: RP
authors.lastname: Macoch
authors.affiliation: Laboratory of Cellular Engineering, M. Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, 02-781 Warsaw, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Zolocinska
authors.affiliation: Department of Breast Cancer and Reconstructive Surgery, Oncology Center-Institute, Warsaw, Poland.
authors.forename: Slawomir
authors.initials: S
authors.lastname: Mazur
authors.affiliation: Laboratory of Cellular Engineering, M. Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, 02-781 Warsaw, Poland.
authors.forename: Katarzyna
authors.identifier: 0000-0002-1612-939X
authors.initials: K
authors.lastname: Siennicka
authors.affiliation: Department of Radiology, Military Institute of Medicine, Warsaw, Poland.
authors.forename: Emilia
authors.initials: E
authors.lastname: Frankowska
authors.affiliation: Department of Radiology, Military Institute of Medicine, Warsaw, Poland.
authors.forename: Rafał
authors.initials: R
authors.lastname: Kidzinski
authors.affiliation: Polish Academy of Sciences, Warsaw, Poland.
authors.forename: Małgorzata
authors.identifier: 0000-0003-0361-8626
authors.initials: M
authors.lastname: Chalimoniuk
authors.affiliation: Laboratory of Cellular Engineering, M. Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, 02-781 Warsaw, Poland.
authors.forename: Zygmunt
authors.identifier: 0000-0001-5562-4433
authors.initials: Z
authors.lastname: Pojda
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000473:pathology* / Q000628:therapy*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology