title: Peptides conjugated to silver nanoparticles in biomedicine - a "value-added" phenomenon.
abstract: Nanotechnology is gaining impetus in the present century and particularly the use of nanoparticles (NPs), whose properties are significantly different from the larger matter. These have found wider and potential applications in the fields of medicine, energy, cosmetics, environment and biomedicine. Among the NPs, silver nanoparticles (AgNPs) are of particular interest for scientists and technologists due to their unique physico-chemical and biological properties. Besides, AgNPs by themselves also possess broad-spectrum microbial activity, which has further expanded their application in both academia and industries. On the other hand, research and drug discovery in the field of peptides is surging. Chemistry and biology of peptides have seen a renaissance in this century as many of the peptide-based therapeutics have entered the market and many more are in the different phases of clinical trials. To fuel this, peptides have also found numerous applications in nanotechnology. Taking advantage of these two scenarios, namely, AgNPs and peptides, conjugation of these entities have emerged as a powerful technique and have opened the doors for a new revolution. Keeping this motivation in mind, we here present a mini-review on the combined concept of AgNPs and peptides.
authors.affiliation: Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa. albericio@ukzn.ac.za.
authors.forename: Suhas
authors.initials: S
authors.lastname: Ramesh
authors.affiliation: Centro de Nanociencia y Nanotecnología, Universidad de las Fuerzas Armadas ESPE, P.O. Box 171-5-231B, Sangolquí, Ecuador. lhcumbal@espe.edu.ec.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Grijalva
authors.affiliation: Centro de Nanociencia y Nanotecnología, Universidad de las Fuerzas Armadas ESPE, P.O. Box 171-5-231B, Sangolquí, Ecuador. lhcumbal@espe.edu.ec.
authors.forename: Alexis
authors.initials: A
authors.lastname: Debut
authors.affiliation: Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa. albericio@ukzn.ac.za.
authors.forename: Beatriz G
authors.initials: BG
authors.lastname: de la Torre
authors.affiliation: Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa. albericio@ukzn.ac.za and School of Chemistry and Physics, University of KwaZulu-Natal, Durban 4001, South Africa and CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Barcelona Science Park, 08028 Barcelona, Spain and Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh11451, Saudi Arabia and Department of Organic Chemistry, University of Barcelona, 08028-Barcelona, Spain.
authors.forename: Fernando
authors.identifier: http://orcid.org/0000-0002-8946-0462
authors.initials: F
authors.lastname: Albericio
authors.affiliation: Centro de Nanociencia y Nanotecnología, Universidad de las Fuerzas Armadas ESPE, P.O. Box 171-5-231B, Sangolquí, Ecuador. lhcumbal@espe.edu.ec.
authors.forename: Luis H
authors.initials: LH
authors.lastname: Cumbal
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D001692:Biological Transport; D045744:Cell Line, Tumor; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology; D012834:Silver / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D010455:Peptides; D012834:Silver