title: Orally disintegrating films: A modern expansion in drug delivery system.
abstract: Over the past few decades, tendency toward innovative drug delivery systems has majorly increased attempts to ensure efficacy, safety and patient acceptability. As discovery and development of new chemical agents is a complex, expensive and time consuming process, so recent trends are shifting toward designing and developing innovative drug delivery systems for existing drugs. Out of those, drug delivery system being very eminent among pediatrics and geriatrics is orally disintegrating films (ODFs). These fast disintegrating films have superiority over fast disintegrating tablets as the latter are associated with the risks of choking and friability. This drug delivery system has numerous advantages over conventional fast disintegrating tablets as they can be used for dysphasic and schizophrenic patients and are taken without water due to their ability to disintegrate within a few seconds releasing medication in mouth. Various approaches are employed for formulating ODFs and among which solvent casting and spraying methods are frequently used. Generally, hydrophilic polymers along with other excipients are used for preparing ODFs which allow films to disintegrate quickly releasing incorporated active pharmaceutical ingredient (API) within seconds. Orally disintegrating films have potential for business and market exploitation because of their myriad of benefits over orally disintegrating tablets. This present review attempts to focus on benefits, composition, approaches for formulation and evaluation of ODFs. Additionally, the market prospect of this innovative dosage form is also targeted.
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, GC University, Faisalabad, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Irfan
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, GC University, Faisalabad, Pakistan.
authors.forename: Sumeira
authors.initials: S
authors.lastname: Rabel
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, GC University, Faisalabad, Pakistan.
authors.forename: Quratulain
authors.initials: Q
authors.lastname: Bukhtar
authors.affiliation: Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan.
authors.forename: Muhammad Imran
authors.initials: MI
authors.lastname: Qadir
authors.affiliation: Department of Zoology, Wildlife & Fisheries, GC University, Faisalabad, Pakistan.
authors.forename: Farhat
authors.initials: F
authors.lastname: Jabeen
authors.affiliation: Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Khan
keywords: Formulation parameters; Manufacturing techniques; Novel drug delivery; ODFs