title: Evaluation of Serum S100A8/S100A9 Levels in Patients with Autoimmune Thyroid Diseases.
abstract: BACKGROUND
  The correlation of S100A8/S100A9 with various inflammatory conditions, including autoimmune diseases have been reported. There is no study investigating the levels of S100A8/S100A9 in autoimmune thyroid diseases (AITD).
  
  
  OBJECTIVE
  We aimed to evaluate the level of serum S100A8/S100A9 in AITD.
  
  
  METHODS
  Case control study.
  
  
  METHODS
  Fifty patients with AITD (25 Hashimoto's thyroiditis (HT) and 25 Graves' disease (GD)) were included in the study. Twenty seven healthy subjects participated as a control group. Blood samples were obtained in the 3 months after the initiation of medical treatment. Serum levels of total antioxidant status (TAS), total oxidative status (TOS), total free sulfhydryl (SH), lipid hydroperoxide (LOOH) and S100A8/S100A9 were analyzed.
  
  
  RESULTS
  The patients with AITD had significantly higher S100A8/S100A9, OSI, LOOH and TOS levels than the healthy control group. There was no significant difference between GD and HT patients in terms of S100A8/S100A9, TOS and OSI levels. S100A8/S100A9 level was positively correlated with LOOH, TOS and OSI levels but negatively correlated with -SH level in the patients with AITD.
  
  
  CONCLUSIONS
  Serum S100A8/S100A9 levels were increased in patients with AITD and positively correlated with LOOH, TOS and OSI whereas negatively correlated with SH.
authors.affiliation: Department of Endocrinology and Metabolic Disease, Edirne State Hospital, Edirne, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Korkmaz
authors.affiliation: Division of Endocrinology, Department of Internal Medicine, Gaziantep University School of Medicine, Gaziantep, Turkey.
authors.forename: Suzan
authors.initials: S
authors.lastname: Tabur
authors.affiliation: Department of Internal Medicine, Gaziantep University School of Medicine, Gaziantep, Turkey.
authors.forename: Esen
authors.initials: E
authors.lastname: Savaş
authors.affiliation: Division of Endocrinology, Department of Internal Medicine, Gaziantep University School of Medicine, Gaziantep, Turkey.
authors.forename: Mesut
authors.initials: M
authors.lastname: Özkaya
authors.affiliation: Department of Clinical Biochemistry, Gaziantep University School of Medicine, Gaziantep, Turkey.
authors.forename: Şefika Nur
authors.initials: ŞN
authors.lastname: Aksoy
authors.affiliation: Department of Clinical Biochemistry, Harran University School of Medicine, Şanlıurfa, Turkey.
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
authors.affiliation: Division of Endocrinology, Department of Internal Medicine, Gaziantep University School of Medicine, Gaziantep, Turkey.
authors.forename: Ersin
authors.initials: E
authors.lastname: Akarsu
keywords: Autoimmune thyroid disease; S100A8/S100A9; oxidative status