title: Vaginal Probiotic Administration in the Management of Preterm Premature Rupture of Membranes.
abstract: OBJECTIVE
  To examine the influence of vaginal probiotic administration as an adjunct to standard antibiotic treatment on perinatal outcome in women with preterm premature rupture of membranes (PPROM).
  
  
  METHODS
  This was a prospective randomized trial of cases with PPROM (24-34 weeks) that were admitted to our department between 2011 and 2015. Forty-nine cases received vaginal probiotics for 10 days in combination with antibiotic prophylaxis and were compared to 57 others that received only antibiotics for the same time period.
  
  
  RESULTS
  The mean gestational age at birth (35.49 vs. 32.53 weeks), the mean duration of the latency period (5.60 vs. 2.48 weeks), and the mean birth weight (2,439.08 vs. 2,004.81 g) were significantly higher in the study group in comparison to the controls. Moreover, the neonates of the study group had a lower chance to enter the neonatal intensive care unit or the neonatal special care unit, shorter total hospitalization time, and lower need for oxygen administration and mechanical ventilation, as well as lower length of oxygen administration.
  
  
  CONCLUSIONS
  Vaginal probiotics as an adjunct to antibiotic prophylaxis in women with PPROM prolonged the latency period and improved the perinatal outcome.
authors.affiliation: 1st Department of Obstetrics and Gynecology, "Alexandra" Maternity Hospital, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: George J
authors.initials: GJ
authors.lastname: Daskalakis
authors.forename: Alexis K
authors.initials: AK
authors.lastname: Karambelas
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D019072:Antibiotic Prophylaxis; D004359:Drug Therapy, Combination; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000188:drug therapy*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000517:prevention & control*; D019936:Probiotics / Q000008:administration & dosage / Q000627:therapeutic use*; D011446:Prospective Studies; D016896:Treatment Outcome; D055815:Young Adult
keywords: Gestational age at delivery; Latency to delivery; Preterm premature rupture of membranes; Probiotics