title: Prognostic effect of pre- and post-admission antibiotic treatment in paediatric acute mastoiditis.
abstract: OBJECTIVE
  To evaluate the effect of pre- and post-admission antibiotic treatment in paediatric acute mastoiditis.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Eighty-eight children with acute mastoiditis, from 2003 to 2012, were studied to investigate the effect of antibiotic therapy on short and long-term sequelae.
  
  
  RESULTS
  The median period of antibiotic therapy immediately following hospital discharge was 10 days (range, 5-49 days; standard deviation = 7.46). There were no sequelae within the fortnight following antibiotic therapy completion, but 14 of 40 patients had significant sequelae thereafter, including recurrent otorrhoea, acute otitis media and ventilation tube insertion requirement. Complication rates were significantly higher among patients who had pre-admission antibiotic therapy (52 per cent), compared to patients previously untreated (27 per cent).
  
  
  CONCLUSIONS
  Paediatric acute mastoiditis patients treated with antibiotic therapy prior to admission are at higher risk for complication development. The advised time period for oral antibiotic therapy following hospital discharge remains as 10 days in all cases of uncomplicated acute mastoiditis.
authors.affiliation: Department of Paediatric Otolaryngology,Children's Hospital at Westmead,Sydney,Australia.
authors.forename: E
authors.initials: E
authors.lastname: Carmel
authors.affiliation: Department of Paediatric Otolaryngology,Children's Hospital at Westmead,Sydney,Australia.
authors.forename: J H
authors.initials: JH
authors.lastname: Curotta
authors.affiliation: Department of Paediatric Otolaryngology,Children's Hospital at Westmead,Sydney,Australia.
authors.forename: A T
authors.initials: AT
authors.lastname: Cheng
mesh_terms: D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007902:Length of Stay; D008297:Male; D008417:Mastoiditis / Q000188:drug therapy*; D008876:Middle Ear Ventilation / Q000706:statistics & numerical data; D010033:Otitis Media; D010406:Penicillins / Q000627:therapeutic use*; D011379:Prognosis; D012008:Recurrence; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D010406:Penicillins
keywords: Antibiotics; Child; Mastoiditis; Otitis Media; Pediatrics