title: Click Chemistry in the Development of Contrast Agents for Magnetic Resonance Imaging.
abstract: Click chemistry provides fast, convenient, versatile, and reliable chemical reactions that take place between pairs of functional groups of small molecules that can be purified without chromatographic methods. Due to the fast kinetics and low or no elimination of byproducts, click chemistry is a promising approach that is rapidly gaining acceptance in drug discovery, radiochemistry, bioconjugation, and nanoscience applications. Increasing use of click chemistry in synthetic procedures or as a bioconjugation technique in diagnostic imaging is occurring because click reactions are fast, provide a quantitative yield, and produce a minimal amount of nontoxic byproducts. This review summarizes the recent application of click chemistry in magnetic resonance imaging and discusses the directions for applying novel click reactions and strategies for further improving magnetic resonance imaging performance.
authors.affiliation: *Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science †Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD.
authors.forename: Sudath
authors.initials: S
authors.lastname: Hapuarachchige
authors.forename: Dmitri
authors.initials: D
authors.lastname: Artemov
mesh_terms: D057930:Click Chemistry; D003287:Contrast Media / Q000737:chemistry*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000639:trends; D015394:Molecular Structure
chemical_list: D003287:Contrast Media