title: Metabolic abnormality in the right dorsolateral prefrontal cortex in patients with obsessive-compulsive disorder: proton magnetic resonance spectroscopy.
abstract: OBJECTIVE
  Proton magnetic resonance spectroscopy (1H-MRS) was used to evaluate metabolic changes in the dorsolateral prefrontal cortex (DLPFC) in patients with obsessive-compulsive disorder (OCD).
  
  
  METHODS
  In total, 14 OCD patients (mean age 28.9±7.2 years) and 14 healthy controls (mean age 32.6±7.1 years) with no history of neurological and psychiatric illness participated in this study. Brain metabolite concentrations were measured from a localised voxel on the right DLPFC using a 3-Tesla 1H-MRS.
  
  
  RESULTS
  The metabolic concentration of myo-inositol in patients with OCD increased significantly by 52% compared with the healthy controls, whereas glutamine/glutamate was decreased by 11%. However, there were no significant differences in N-acetylaspartate, choline, lactate and lipid between the two groups.
  
  
  CONCLUSIONS
  These findings would be helpful to understand the pathophysiology of OCD associated with the brain metabolic abnormalities in the right DLPFC.
authors.affiliation: 1Interdisciplinary Program of Biomedical Engineering,Chonnam National University,Gwangju,Republic of Korea.
authors.forename: Shin-Eui
authors.initials: SE
authors.lastname: Park
authors.affiliation: 2Department of Radiology,DongShin University,Naju,Republic of Korea.
authors.forename: Nam-Gil
authors.initials: NG
authors.lastname: Choi
authors.affiliation: 1Interdisciplinary Program of Biomedical Engineering,Chonnam National University,Gwangju,Republic of Korea.
authors.forename: Gwang-Woo
authors.initials: GW
authors.lastname: Jeong
mesh_terms: D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D002794:Choline / Q000378:metabolism; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism; D005973:Glutamine / Q000378:metabolism; D006801:Humans; D007294:Inositol / Q000378:metabolism; D019344:Lactic Acid / Q000378:metabolism; D008297:Male; D059906:Neuroimaging / Q000379:methods; D009771:Obsessive-Compulsive Disorder / Q000378:metabolism*; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D066244:Proton Magnetic Resonance Spectroscopy / Q000379:methods*; D055815:Young Adult
chemical_list: D005973:Glutamine; D001224:Aspartic Acid; D019344:Lactic Acid; D018698:Glutamic Acid; D007294:Inositol; C000179:N-acetylaspartate; D002794:Choline
keywords: dorsolateral prefrontal cortex (DLPFC); obsessive–compulsive disorder (OCD); proton magnetic resonance spectroscopy (1H-MRS)