title: Hematological and pathological features of massive hepatic necrosis in two radiated tortoises (Astrochelys radiata).
abstract: Two radiated tortoises (Astrochelys radiata) exhibited anorexia and hypokinesia. In both cases, hematological and serum biochemical examinations revealed high alkaline phosphatase levels, moderately high aspartate aminotransferase levels and white blood cell counts approximately within the normal range. Despite being treated, the tortoises died 9 and 43 days after the first clinical examination. Gross pathological examinations revealed that the livers of both animals were extremely swollen and contained pale yellow necrotic tissue. Histopathological assessment revealed that the livers contained a massive area of hepatic necrosis surrounded by migration of macrophages and multinucleated giant cells. In one of the cases, severe fibrosis was observed. The present study provides reference information for similar cases in the future.
authors.affiliation: Nogeyama Zoological Gardens, Yokohama Greenery Foundation, 63-10, Oimatsu cho, Nishi ku, Yokohama, Kanagawa 220-0032, Japan.
authors.forename: Nobuhide
authors.initials: N
authors.lastname: Kido
authors.forename: Iori
authors.initials: I
authors.lastname: Itagaki
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kiryu
authors.forename: Tomoko
authors.initials: T
authors.lastname: Omiya
authors.forename: Kaori
authors.initials: K
authors.lastname: Ono
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D017809:Fatal Outcome; D005260:Female; D007962:Leukocytes / Q000473:pathology; D008103:Liver Cirrhosis / Q000662:veterinary; D047508:Massive Hepatic Necrosis / Q000473:pathology / Q000662:veterinary*; D014426:Turtles
chemical_list: D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase