title: Microcirculatory Responses to Hyperoxia in Macular and Peripapillary Regions.
abstract: OBJECTIVE
  To evaluate the hyperoxia response of the retinal vascular system in different parts of the fundus using optical coherence tomography (OCT) angiography.
  
  
  METHODS
  Using an OCT angiography system and a split-spectrum amplitude decorrelation angiography (SSADA) algorithm, perfused vessel density at the macular and peripapillary regions was measured before and after breathing 80% oxygen in 10 healthy Chinese subjects. The repeatability of the hyperoxia response was also tested.
  
  
  RESULTS
  Hyperoxia provocation caused a significant decrease in retinal perfused vessel density in both the macular and peripapillary areas. The para- and perifoveal area had a mean reduction of 13.66% and 15.17%, respectively; these reductions were significantly greater than in the peripapillary area (9.52%; parafovea versus peripapillary, P = 0.023; perifovea versus peripapillary, P = 0.006). The coefficients of variation (CV), intraclass correlations (ICC), and Bland-Altman plots suggested strong repeatability of the hyperoxia response.
  
  
  CONCLUSIONS
  The optical coherence tomography system, in conjunction with the SSADA algorithm, recorded a significant reduction in retinal perfused vessel density after hyperoxia, and the reduction was greater in the macular area than in the peripapillary area.
authors.affiliation: Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, People's Republic of China 2Key Laboratory of Myopia of the State Health Ministry, and Key Laboratory of Visual Impairment and Restoration of Shanghai, Shanghai, People's Republic of China.
authors.forename: Huan
authors.initials: H
authors.lastname: Xu
authors.affiliation: Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, People's Republic of China 3Department of Ophthalmology, The Third People's Hospital of Changzhou, Changzhou, People's Republic of China.
authors.forename: Guohua
authors.initials: G
authors.lastname: Deng
authors.affiliation: Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, People's Republic of China 2Key Laboratory of Myopia of the State Health Ministry, and Key Laboratory of Visual Impairment and Restoration of Shanghai, Shanghai, People's Republic of China 4Department of Ophthalmology, People's Hospital of Shanghai No. 5, Shanghai, People's Republic of China.
authors.forename: Chunhui
authors.initials: C
authors.lastname: Jiang
authors.affiliation: Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, People's Republic of China 2Key Laboratory of Myopia of the State Health Ministry, and Key Laboratory of Visual Impairment and Restoration of Shanghai, Shanghai, People's Republic of China.
authors.forename: Xiangmei
authors.initials: X
authors.lastname: Kong
authors.affiliation: Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, People's Republic of China 2Key Laboratory of Myopia of the State Health Ministry, and Key Laboratory of Visual Impairment and Restoration of Shanghai, Shanghai, People's Republic of China.
authors.forename: Jian
authors.initials: J
authors.lastname: Yu
authors.affiliation: Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, People's Republic of China 2Key Laboratory of Myopia of the State Health Ministry, and Key Laboratory of Visual Impairment and Restoration of Shanghai, Shanghai, People's Republic of China.
authors.forename: Xinghuai
authors.initials: X
authors.lastname: Sun
mesh_terms: D000465:Algorithms; D005451:Fluorescein Angiography / Q000379:methods*; D005654:Fundus Oculi; D064368:Healthy Volunteers; D006801:Humans; D018496:Hyperoxia / Q000175:diagnosis / Q000503:physiopathology*; D008266:Macula Lutea / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology*; D008833:Microcirculation / Q000502:physiology*; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology / Q000503:physiopathology*; D041623:Tomography, Optical Coherence / Q000379:methods*