title: The effect of prediabetes on hepatocellular carcinoma risk: a systematic review and meta-analysis.
abstract: BACKGROUND
  Some studies suggested an increased risk of hepatocellular carcinoma (HCC) risk in subjects with prediabetes, whereas other studies have reported negative results. Therefore, we did this meta-analysis to assess the role of prediabetes on HCC risk.
  
  
  METHODS
  We searched studies from PubMed, Embase, and Web of Science databases. The strength of association between prediabetes and HCC risk was assessed by calculating hazard ratio (HR) with 95% CI.
  
  
  RESULTS
  A total of 8 cohort studies and 1 case-control study with 1384594 individuals were included. Patients with prediabetes showed an increased HCC risk (HR=1.21; 95% CI, 1.13-1.30; P<0.00001). Subgroup analyses were performed according to race and gender. The results showed that both Asians with prediabetes (HR=1.19; 95% CI, 1.11-1.28; P<0.00001) and Caucasians with prediabetes (HR=2.12; 95% CI, 1.36-3.31; P=0.001 were significantly associated with increased risk of HCC, respectively. In the subgroup analysis by gender, both male patients with prediabetes (HR=1.49; 95% CI, 1.03-2.15; P=0.03) and female patients with prediabetes (HR=1.24; 95% CI, 1.01-1.52; P=0.04) showed increased risk of HCC, respectively.
  
  
  CONCLUSIONS
  In conclusion, this meta-analysis demonstrated that prediabetes might be a risk factor of HCC.
authors.affiliation: Department of Geriatrics, Guangzhou General Hospital of Guangzhou Military Command, Guangdong, China - xuweiguogz@163.com.
authors.forename: Wei-Guo
authors.initials: WG
authors.lastname: Xu
authors.affiliation: Department of Geriatrics, Guangzhou General Hospital of Guangzhou Military Command, Guangdong, China.
authors.forename: Yun-Feng
authors.initials: YF
authors.lastname: Qian
authors.affiliation: Department of Geriatrics, Guangzhou General Hospital of Guangzhou Military Command, Guangdong, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
mesh_terms: D044466:Asian People; D006528:Carcinoma, Hepatocellular / Q000208:ethnology / Q000209:etiology*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000208:ethnology / Q000209:etiology*; D008297:Male; D011236:Prediabetic State / Q000150:complications* / Q000208:ethnology; D012306:Risk; D012737:Sex Factors; D044465:White People