title: Transition-metal-free oxidative C5 C-H-halogenation of 8-aminoquinoline amides using sodium halides.
abstract: A simple and efficient transition-metal-free oxidative halogenation (Cl, Br) of the C5 C-H bond of 8-aminoquinoline amides has been developed. This method employed low-cost and innoxious sodium halides as halogenation reagents and oxone as an oxidant. The reactions demonstrated air and moisture tolerance, and good functional group compatibility, giving highly selective C5-halogenated products in good to excellent yields.
authors.affiliation: School of Materials and Chemical Engineering, Hubei University of Technology, Wuhan 430068, China. dongli@mail.hbut.edu.cn zhangqian620@hotmail.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Materials and Chemical Engineering, Hubei University of Technology, Wuhan 430068, China. dongli@mail.hbut.edu.cn zhangqian620@hotmail.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Materials and Chemical Engineering, Hubei University of Technology, Wuhan 430068, China. dongli@mail.hbut.edu.cn zhangqian620@hotmail.com.
authors.forename: Kai
authors.initials: K
authors.lastname: Jiang
authors.affiliation: School of Materials and Chemical Engineering, Hubei University of Technology, Wuhan 430068, China. dongli@mail.hbut.edu.cn zhangqian620@hotmail.com and Hubei Key Laboratory of Drug Synthesis and Optimization, Jingchu University of Technology, Jingmen 448000, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: School of Materials and Chemical Engineering, Hubei University of Technology, Wuhan 430068, China. dongli@mail.hbut.edu.cn zhangqian620@hotmail.com.
authors.forename: Dong
authors.identifier: http://orcid.org/0000-0002-1246-1926
authors.initials: D
authors.lastname: Li