title: Capgermacrenes D-G, new sesquiterpenoids from a Bornean soft coral, Capnella imbricata.
abstract: Four new bicyclogermacrenes, capgermacrenes D (1) E (2) F (3) and G (4) were isolated from a population of Bornean soft coral Capnella imbricata. The structures of these metabolites were elucidated based on their nuclear magnetic resonance and high-resolution electrospray ionisation mass spectrometry spectral data. These compounds showed bacteriastatic and bacteriacidal activities against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus.
authors.affiliation: a Laboratory of Natural Products Chemistry , Institute for Tropical Biology and Conservation, Universiti of Malaysia Sabah , Kota Kinabalu , Malaysia.
authors.forename: Chin-Soon
authors.initials: CS
authors.lastname: Phan
authors.affiliation: a Laboratory of Natural Products Chemistry , Institute for Tropical Biology and Conservation, Universiti of Malaysia Sabah , Kota Kinabalu , Malaysia.
authors.forename: Charles Santhanaraju
authors.initials: CS
authors.lastname: Vairappan
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001893:Borneo; D004353:Drug Evaluation, Preclinical / Q000379:methods; D009682:Magnetic Resonance Spectroscopy; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D012717:Sesquiterpenes
keywords: Alcyoniidae; Capnella imbricata; Soft coral; germacrene; sesquiterpene