title: Objective Assessment of Ocular Surface Response to Contact Lens Wear in Presbyopic Contact Lens Wearers of Asian Descent.
abstract: BACKGROUND
  Contact lens wearers of Asian descent may be predisposed to experience microtrauma of the ocular surface as a result a thinner post-lens tear film and higher eyelid tension, and these effects would be anticipated to be most marked in an older population. The objective of this study was to quantify the mechanical effects of the study contact lenses on the ocular surface in a population of presbyopic contact lens wearers of Asian descent.
  
  
  METHODS
  Twenty established presbyopic contact lens wearers (hydrogel n=5, none habitual wearers of etafilcon A lenses; silicone hydrogel n=15) of Asian descent were refitted with etafilcon A multifocal daily disposable contact lenses (1-DAY ACUVUE MOIST MULTIFOCAL) for a period of 1 month of daily lens wear. The habitual modalities of wear were 45% daily disposable and 55% planned replacement. Digital photographs of the upper lid margins, nasal and temporal conjunctiva, and superior cornea were taken after 6 hr of wear of the participants' habitual contact lenses, after 1 day without contact lens wear, and after 6 hr of wear of the study contact lenses at the end of the 1-month period. The photographs were masked according to study visit and the staining extent measured using proprietary software.
  
  
  RESULTS
  Lid margin staining was significantly lower with the study contact lenses (2.0±1.0 mm) than with the participants' own contact lenses (3.2±3.0 mm) after 6 hr of wear, representing a mean staining decrease of 38% (P=0.010). Lid margin staining after 6 hr of wear of the study contact lenses was not different from that measured after 1 day without contact lenses (P=0.507). Limbal staining was also significantly less with the study contact lenses than with the participants' own contact lenses after 6 hr of wear (P=0.009). There was minimal upper corneal staining, and the degree was similar with the study and habitual lenses.
  
  
  CONCLUSIONS
  Etafilcon A material, worn under a daily disposable modality, was shown to reduce upper lid margin and limbal staining in presbyopic contact lens wearers of Asian descent compared with the wearers' own contact lenses. Because of the high preponderance of dry eye amongst presbyopes, material selection is of importance and consideration should be given to the lens-ocular surface interaction.
authors.affiliation: OCULAR TECHNOLOGY GROUP-International (M.G., K.D., P.T., T.P.), London, United Kingdom; School of Life and Health Science (M.G.), Aston University, Birmingham, United Kingdom; and Johnson & Johnson Vision Care Inc. (T.K., K.M.), Jacksonville, FL.
authors.forename: Michel
authors.initials: M
authors.lastname: Guillon
authors.forename: Kathy
authors.initials: K
authors.lastname: Dumbleton
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Theodoratos
authors.forename: Trisha
authors.initials: T
authors.lastname: Patel
authors.forename: Tom
authors.initials: T
authors.lastname: Karkkainen
authors.forename: Kurt
authors.initials: K
authors.lastname: Moody
mesh_terms: D000328:Adult; D044466:Asian People; D003228:Conjunctiva / Q000473:pathology; D003263:Contact Lenses, Hydrophilic / Q000009:adverse effects*; D003315:Cornea / Q000473:pathology; D004209:Disposable Equipment; D005143:Eyelids / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D011305:Presbyopia / Q000534:rehabilitation*; D011446:Prospective Studies; D014785:Vision, Ocular