title: Spontaneous tumour lysis syndrome in hepatocellular carcinoma presenting with hypocalcemic tetany: An unusual case and systematic literature review.
abstract: Tumour lysis syndrome is an oncological emergency which is usually seen following chemotherapy for rapidly proliferating haematological malignancies. Spontaneous tumour lysis syndrome is rare in solid tumour and even rarer with hepatocellular carcinoma (HCC). Tumour lysis syndrome in the setting of HCC is usually reported as a consequence of therapeutic interventions like sorafenib administration or trans-arterial chemoembolization. We report about a case of a young lady with chronic hepatitis B related HCC who developed spontaneous tumour lysis syndrome and presented with hypocalcemic tetany. We also compare this case with the previously reported cases of spontaneous tumour lysis syndrome in hepatocellular carcinoma.
authors.affiliation: Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, India.
authors.forename: Roshan
authors.initials: R
authors.lastname: Agarwala
authors.affiliation: Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, India.
authors.forename: Akash
authors.initials: A
authors.lastname: Batta
authors.affiliation: Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, India.
authors.forename: Varun
authors.initials: V
authors.lastname: Suryadevera
authors.affiliation: Department of Nephrology, Postgraduate Institute of Medical Education and Research, India.
authors.forename: Vivek
authors.initials: V
authors.lastname: Kumar
authors.affiliation: Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, India. Electronic address: docvishalsharma@gmail.com.
authors.forename: Vishal
authors.initials: V
authors.lastname: Sharma
authors.affiliation: Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, India.
authors.forename: Surinder Singh
authors.initials: SS
authors.lastname: Rana
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D001201:Ascites / Q000209:etiology; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications*; D006801:Humans; D006996:Hypocalcemia / Q000209:etiology*; D008103:Liver Cirrhosis / Q000150:complications* / Q000175:diagnosis / Q000209:etiology; D008113:Liver Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D009367:Neoplasm Staging; D010166:Palliative Care; D010360:Patient Transfer; D016312:Treatment Refusal; D015275:Tumor Lysis Syndrome / Q000209:etiology*