title: Development of an electrochemical188W/188Re generator as a technique for separation and purification of188Re in radiopharmaceutical applications.
abstract: In this study, a simple electrochemical procedure adaptable for using low specific activity188W for separation and purification of188Re from188W to obtain no carrier added (NCA)188Re is developed. The electrochemical parameters were optimized to maximize the188Re electrodeposition yield with minimal188W contamination. Two cycle electrolysis procedure was developed. The first electrochemical cell was used for separation of188Re and in the second electrochemical cell, separation and purification of188Re with >90% deposition yield of188Re and minimal contamination of188W (<10-4%) was achieved. The overall electrodeposition yield of188Re was >90% with >99% radionuclidic purity and >99% radiochemical purity suitable for radiopharmaceutical applications. Furthermore, the performance of the generator remained consistent during a period of 69 days, one half-life of188W, when the electrochemical separation procedure was performed frequently, at least once in 5 days.
authors.affiliation: Department of Energy Engineering and Physics, Amirkabir University of Technology, 15875-4413 Tehran, Iran.
authors.forename: Bakhtiar
authors.initials: B
authors.lastname: Azadbakht
authors.affiliation: Department of Energy Engineering and Physics, Amirkabir University of Technology, 15875-4413 Tehran, Iran. Electronic address: hafarideh@aut.ac.ir.
authors.forename: Hossein
authors.initials: H
authors.lastname: Afarideh
authors.affiliation: Nuclear Science and Technology Research Institute (NSTRI), P.O. Box:14395-836, Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ghannadi-Maragheh
authors.affiliation: Nuclear Science and Technology Research Institute (NSTRI), P.O. Box:14395-836, Tehran, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Asgari
authors.affiliation: Nuclear Science and Technology Research Institute (NSTRI), P.O. Box:14395-836, Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Bahrami-Samani
keywords: (188)W/(188)Re generator; Electrodeposition yield; Radiochemical purity; Radionuclidic purity; Separation