title: Intraoperative Portal Flow of Less Than 1 Liter per Minute After Orthotopic Liver Transplantation Is Not Associated Per Se With an Increased Rate of Early Graft Dysfunction.
abstract: OBJECTIVE
  The aim of this study was to determine whether a portal flow of <1,000 mL/min in orthotopic liver transplantation (OLT) is associated with a higher incidence of early graft dysfunction (EGD) and graft loss.
  
  
  METHODS
  A retrospective study was performed of 540 OLTs carried out consecutively from December 2004 to December 2013. Patients were divided into 2 groups: group A, portal flow <1,000 mL/min; and group B, portal flow >1,000 mL/min. We studied the incidence of EGD and graft survival. A subanalysis was performed to define the minimum acceptable portal flow/100 g of liver weight to reduce the development EGD and graft loss.
  
  
  RESULTS
  Group A included 29 patients and group B, 511 patients. Group A had significantly lower-weight donors and recipients, female recipients with cholestatic disease, lower MELD scores, and lower hepatic artery flow. EGD occurred in 7 patients in group A (24.1%) versus 101 patients in group B (19.8%; P = .43). No significant differences were found in 1- and 5-year graft survival. A portal flow of <80 mL/min/100 g of liver weight was related to a significantly higher risk of developing EGD (odds ratio, 4.35; 95% confidence interval [CI], 1.46-12.91; P = .008) and graft loss (hazard ratio, 4.05; 95% CI, 1.32-12.42; P = .014).
  
  
  CONCLUSIONS
  Intraoperative portal flow of <1,000 mL/min in OLT was not related per se with a higher incidence of EGD or graft loss. Significantly higher risk of developing EGD and graft loss was associated with a portal flow of <80 mL/min/100 g of liver weight.
authors.affiliation: Hepatobiliary Surgery and Liver Transplantation Unit, Cruces University Hospital, University of the Basque Country, Bilbao, Spain. Electronic address: mikelgastaca@gmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Gastaca
authors.affiliation: Hepatobiliary Surgery and Liver Transplantation Unit, Cruces University Hospital, University of the Basque Country, Bilbao, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Prieto
authors.affiliation: Hepatobiliary Surgery and Liver Transplantation Unit, Cruces University Hospital, University of the Basque Country, Bilbao, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Valdivieso
authors.affiliation: Hepatobiliary Surgery and Liver Transplantation Unit, Cruces University Hospital, University of the Basque Country, Bilbao, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Ruiz
authors.affiliation: Hepatobiliary Surgery and Liver Transplantation Unit, Cruces University Hospital, University of the Basque Country, Bilbao, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Ventoso
authors.affiliation: Hepatobiliary Surgery and Liver Transplantation Unit, Cruces University Hospital, University of the Basque Country, Bilbao, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Palomares
authors.affiliation: Hepatobiliary Surgery and Liver Transplantation Unit, Cruces University Hospital, University of the Basque Country, Bilbao, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Matarranz
authors.affiliation: Clinical Epidemiology Unit, Cruces University Hospital, Biocruces Health Research Institute, Bilbao, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Martinez-Indart
authors.affiliation: Hepatobiliary Surgery and Liver Transplantation Unit, Cruces University Hospital, University of the Basque Country, Bilbao, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Ortiz de Urbina
mesh_terms: D000328:Adult; D005260:Female; D006085:Graft Survival; D006801:Humans; D015994:Incidence; D008099:Liver / Q000098:blood supply*; D008102:Liver Circulation; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D055031:Primary Graft Dysfunction / Q000453:epidemiology*; D012189:Retrospective Studies