title: Regulation of Interleukin-23 Expression in Health and Disease.
abstract: Interleukin (IL)-23 plays a central role in the orchestration of inflammatory responses. Produced by dendritic cells and macrophages, this cytokine promotes the protection of the host against mucosal pathogens through the induction of IL-17 and related cytokines by lymphoid cells. Preclinical disease models and association studies in humans have also clearly demonstrated the implication of IL-23 signalling pathway in inflammatory diseases. Indeed, this cytokine is now considered as a major therapeutic target in immune-based pathologies such as psoriasis, ankylosing spondylitis or Crohn's disease. Furthermore, in the context of inflammation-related cancer, IL-23 is thought to contribute to tumorigenesis and progression to metastatic disease. Herein, we review our current understanding of IL-23 regulation at the transcriptional and post-transcriptional levels. We discuss the relevance of these findings in the context of infection, chronic inflammation and cancer.
authors.affiliation: WELBIO and Institute for Medical Immunology (IMI), Université Libre de Bruxelles, 8 rue Adrienne Bolland, B-6041, Charleroi, Belgium.
authors.forename: Iain
authors.initials: I
authors.lastname: Welsby
authors.affiliation: WELBIO and Institute for Medical Immunology (IMI), Université Libre de Bruxelles, 8 rue Adrienne Bolland, B-6041, Charleroi, Belgium. stgoriel@ulb.ac.be.
authors.forename: Stanislas
authors.initials: S
authors.lastname: Goriely
mesh_terms: D000818:Animals; D003424:Crohn Disease / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D004194:Disease / Q000235:genetics*; D005786:Gene Expression Regulation; D006262:Health; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D053759:Interleukin-23 / Q000235:genetics* / Q000378:metabolism*; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000235:genetics / Q000276:immunology; D011565:Psoriasis / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D013167:Spondylitis, Ankylosing / Q000235:genetics / Q000276:immunology / Q000378:metabolism
chemical_list: D053759:Interleukin-23
keywords: Cancer; Dendritic cells; ER stress; Epigenetic; IL-23; Inflammation; TLR; Transcription factors; mRNA stability