title: Impact of obesity on bone metabolism.
abstract: High weight is a protective factor against osteoporosis and risk of fracture. In obesity, however, where overweight is associated to excess fat, this relationship does not appear to be so clear, excess weight has sometimes been associated to decreased bone mass. Obesity interferes with bone metabolism through mechanical, hormonal, and inflammatory factors. These factors are closely related to weight, body composition, and dietary patterns of these patients. The net beneficial or harmful effect on bone mass or risk of fracture of the different components of this condition is not well known. We need to recognize patients at a greater risk of bone disease related to obesity to start an adequate intervention.
authors.affiliation: Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario de Valladolid, Valladolid, España; Instituto Endocrinología y Nutrición Valladolid, Valladolid, España. Electronic address: jjlopez161282@hotmail.com.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: López-Gómez
authors.affiliation: Instituto Endocrinología y Nutrición Valladolid, Valladolid, España; Servicio de Medicina Interna, Hospital Universitario Rio Hortega, Valladolid, España.
authors.forename: José L
authors.initials: JL
authors.lastname: Pérez Castrillón
authors.affiliation: Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario de Valladolid, Valladolid, España; Instituto Endocrinología y Nutrición Valladolid, Valladolid, España.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: de Luis Román
mesh_terms: D054392:Adipokines / Q000502:physiology; D000273:Adipose Tissue / Q000378:metabolism / Q000473:pathology; D001823:Body Composition; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D004198:Disease Susceptibility; D050723:Fractures, Bone / Q000453:epidemiology / Q000209:etiology; D006728:Hormones / Q000502:physiology; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000209:etiology / Q000378:metabolism; D007333:Insulin Resistance; D009765:Obesity / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D010024:Osteoporosis / Q000453:epidemiology / Q000209:etiology; D010758:Phosphorus / Q000378:metabolism; D012307:Risk Factors; D055948:Sarcopenia / Q000209:etiology / Q000378:metabolism
chemical_list: D054392:Adipokines; D006728:Hormones; D010758:Phosphorus; D002118:Calcium
keywords: Adipocitocinas; Adypocytokines; Bone turnover; Obesidad; Obesity; Remodelado óseo; Vitamin D; Vitamina D