title: [An experimental study of anticonvulsant effects of myo-inositol and folic acid].
abstract: OBJECTIVE
  To study the micronutrients that potentiate the action of anticonvulsant drugs, and in particular, of myo-inositol (vitamin B8).
  
  
  METHODS
  An experimental study of neurotrophic and anticonvulsant effects of a preparation based on myo-inositol (inofert) on thiosemicarbazide models of seizures was carried out.
  
  
  RESULTS
  Inofert significantly increased the latent time before the first convulsive seizure, reduced the severity of seizures (p<0.05) and reduced mortality in the models of thiosemicarbazide seizures. Myo-inositol enhanced anticonvulsant action of gabapentin and sodium valproate; neuroprotective effect of myo-inositol was also confirmed.
  
  
  CONCLUSIONS
  The Inofert preparation, containing myo-inositol and folic acid, modulates the effects of drugs with both convulsive and anticonvulsive action, reduces the severity and duration of seizures caused by thiosemicarbazide and increases the survival rate of animals.
authors.affiliation: Ivanovo State Medical Academy, Ivanovo, Russia.
authors.forename: A G
authors.initials: AG
authors.lastname: Kalacheva
authors.affiliation: Ivanovo State Medical Academy, Ivanovo, Russia; RSC 'Neurobiology' of Trace Element Institute for UNESCO, Moscow, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Gromova
authors.affiliation: Ivanovo State Medical Academy, Ivanovo, Russia.
authors.forename: T R
authors.initials: TR
authors.lastname: Grishina
authors.affiliation: Ivanovo State Medical Academy, Ivanovo, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Gogoleva
authors.affiliation: Ivanovo State Medical Academy, Ivanovo, Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Demidov
authors.affiliation: Ivanovo State Medical Academy, Ivanovo, Russia; RSC 'Neurobiology' of Trace Element Institute for UNESCO, Moscow, Russia.
authors.forename: I Y
authors.initials: IY
authors.lastname: Torshin
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005492:Folic Acid / Q000627:therapeutic use*; D007294:Inositol / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*; D012663:Semicarbazides / Q000494:pharmacology; D014635:Valproic Acid / Q000627:therapeutic use; D025101:Vitamin B 6 / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D012663:Semicarbazides; D007294:Inositol; C005151:thiosemicarbazide; D014635:Valproic Acid; D025101:Vitamin B 6; D005492:Folic Acid