title: Turning tumour cells into antigen presenting cells: The next step to improve cancer immunotherapy?
abstract: Downregulation/loss of the antigen presentation is a major immune escape mechanism in cancer. It allows tumour cells to become 'invisible' and avoid immune attack by antitumour T cells. In tumour harbouring properties of professional antigen presenting cells (i.e. tumour B cells in lymphoma), downregulation/loss of the antigen presentation may also prevent direct priming of naïve T cells by tumour cells. Here, we review treatments that may induce/restore antigen presentation by the tumour cells. These treatments may increase the generation of antitumour T cells and/or their capacity to recognise and eliminate tumour cells. By forcing tumour cells to present their antigens, these treatments may sensitise patients to T cell-based immunotherapies, including checkpoint inhibitors.
authors.affiliation: CHU Rennes, Service Hématologie Clinique, F-35033, Rennes, France.
authors.forename: Marie
authors.initials: M
authors.lastname: de Charette
authors.affiliation: Gustave Roussy, Université Paris-Saclay, Département d'Innovation Thérapeutique et d'Essais Précoces, Villejuif, F-94805, France; INSERM U1015, Villejuif, F-94805, France.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Marabelle
authors.affiliation: CHU Rennes, Service Hématologie Clinique, F-35033, Rennes, France; INSERM, U917, F-35043, Rennes, France. Electronic address: roch.houot@chu-rennes.fr.
authors.forename: Roch
authors.initials: R
authors.lastname: Houot
mesh_terms: D017951:Antigen Presentation / Q000276:immunology; D000938:Antigen-Presenting Cells / Q000276:immunology*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D011878:Radiotherapy; D013601:T-Lymphocytes / Q000276:immunology*; D019139:Tumor Escape / Q000276:immunology*
chemical_list: D000970:Antineoplastic Agents; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II
keywords: Antigen presentation; Cancer; Checkpoint inhibitors; Immunotherapy