title: Nanostructured Systems for the Organelle-specific Delivery of Anticancer Drugs.
abstract: Nanotechnology has provided powerful tools to improve the chemotherapy of cancer. Different nanostructures have been developed which deliver the anticancer drugs more selectively to tumor than to healthy tissues. The result has generally been the increase in efficacy and safety of classical anticancer drugs. In recent years, several studies have focused not only on the delivery of anticancer drugs to tumors, but also on delivering the drugs to specific organelles of cancer cells. Endoplasmic reticulum, Golgi apparatus, lysosomes, mitochondria, and nucleus have been the targets of different nanostructured drug delivery systems developed with the goal of circumventing drugresistance, increasing drug efficacy, and so on. So far, the results described in the literature show that this strategy may be used to improve chemotherapy outcomes. In this review a discussion is presented on the strategies described in the literature to deliver anticancer drugs to specific organelles of cancer cells by using nanostructures.
authors.affiliation: Faculty of Ceilandia, University of Brasilia, Brasilia 72220900,. Brazil.
authors.forename: Graziella Anselmo
authors.initials: GA
authors.lastname: Joanitti
authors.forename: Rayane
authors.initials: R
authors.lastname: Ganassin
authors.forename: Mosar Correa
authors.initials: MC
authors.lastname: Rodrigues
authors.forename: Joao Paulo
authors.initials: JP
authors.lastname: Figueiro Longo
authors.forename: Cheng-Shi
authors.initials: CS
authors.lastname: Jiang
authors.forename: Jinsong
authors.initials: J
authors.lastname: Gu
authors.forename: Sandra Milena
authors.initials: SM
authors.lastname: Leal Pinto
authors.forename: Maria de Fatima Menezes
authors.initials: MF
authors.lastname: Almeida Dos Santos
authors.forename: Ricardo Bentes
authors.initials: RB
authors.lastname: de Azevedo
authors.forename: Luis Alexandre
authors.initials: LA
authors.lastname: Muehlmann
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems; D006801:Humans; D050997:Nanomedicine; D049329:Nanostructures / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology*; D015388:Organelles / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents