title: Putative Key Role of Inositol Messengers in Endothelial Cells in Preeclampsia.
abstract: Immunological alterations, endothelial dysfunction, and insulin resistance characterize preeclampsia. Endothelial cells hold the key role in the pathogenesis of this disease. The signaling pathways mediating these biological abnormalities converge on PKB/Akt, an intracellular kinase regulating cell survival, proliferation, and metabolism. Inositol second messengers are involved in metabolic and cell signaling pathways and are highly expressed during preeclampsia. Intracellular action of these molecules is deeply affected by zinc, manganese, and calcium. To evaluate the pathophysiological significance, we present the response of the intracellular pathways of inositol phosphoglycans involved in cellular metabolism and propose a link with the disease.
authors.affiliation: Division of Biosciences, Research Department of Cell and Developmental Biology, University College London, London, UK.
authors.forename: Sirilaksana
authors.initials: S
authors.lastname: Kunjara
authors.affiliation: Division of Biosciences, Research Department of Cell and Developmental Biology, University College London, London, UK.
authors.forename: Patricia
authors.initials: P
authors.lastname: McLean
authors.affiliation: Emergex Vaccines Ltd, Abingdon, Oxfordshire, UK.
authors.forename: Laurens
authors.initials: L
authors.lastname: Rademacher
authors.affiliation: Division of Infection and Immunity, University College London, London, UK.
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Rademacher
authors.affiliation: Department of Biomedical Sciences and Human Oncology (DIMO), II Unit of Obstetrics and Gynecology, University of Bari Aldo Moro, Bari, Italy.
authors.forename: Fabiana
authors.initials: F
authors.lastname: Fascilla
authors.affiliation: Department of Biomedical Sciences and Human Oncology (DIMO), II Unit of Obstetrics and Gynecology, University of Bari Aldo Moro, Bari, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Bettocchi
authors.affiliation: Department of Obstetrics and Gynecology, Sacro Cuore Don Calabria, Negrar, Verona, Italy.
authors.forename: Marco
authors.identifier: 0000-0002-5757-2793
authors.initials: M
authors.lastname: Scioscia