title: LGI1 encephalitis: a disease of jerks and confusion.
abstract: Limbic encephalitis is a group of immune-mediated disorders that includes the classic paraneoplastic encephalitic syndrome and the recently described non-paraneoplastic autoimmune encephalitis most of which target the extracellular antigens. We present a case of 70-year-old man who presented with rapidly progressive cognitive decline and refractory faciobrachial dystonic seizures and demonstrated seropositivity for leucine-rich, glioma-inactivated protein 1 antibodies. After immunomodulation, the patient had dramatic improvement in the cognitive functioning and in seizure control.
authors.affiliation: AIIMS, Delhi, India.
authors.forename: Deepa
authors.initials: D
authors.lastname: Dash
authors.affiliation: Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Madhavi
authors.initials: M
authors.lastname: Tripathi
authors.affiliation: Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Kavish
authors.initials: K
authors.lastname: Ihtisham
authors.affiliation: Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Manjari
authors.initials: M
authors.lastname: Tripathi
mesh_terms: D000368:Aged; D001008:Anxiety Disorders / Q000000981:diagnostic imaging / Q000209:etiology; D003221:Confusion / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D020821:Dystonic Disorders / Q000000981:diagnostic imaging / Q000209:etiology; D006801:Humans; D056747:Immunomodulation; D020363:Limbic Encephalitis / Q000150:complications* / Q000000981:diagnostic imaging / Q000628:therapy; D008297:Male; D000072078:Positron Emission Tomography Computed Tomography; D012640:Seizures / Q000000981:diagnostic imaging / Q000209:etiology; D020323:Tics / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy