title: Risk burdens of modifiable risk factors incorporating lipoprotein (a) and low serum albumin concentrations for first incident acute myocardial infarction.
abstract: Risk burdens of modifiable risk factors incorporating lipoprotein (a) (Lp(a)) and low serum albumin (LSA) concentrations for first incident acute myocardial infarction (AMI) haven't been studied previously. Cross-sectional study of 1552 cases and 6125 controls was performed for identifying the association of risk factors with first incident AMI and their corresponding population attributable risks (PARs). Modifiable risk factors incorporating LSA and Lp(a) accounted for up to 92% of PAR for first incident AMI. Effects of these risk factors were different in different sexes across different age categories. Overall, smoking and LSA were the 2 strongest risk factors, together accounting for 64% of PAR for first incident AMI. After multivariable adjustment, Lp(a) and LSA accounted for 19% and 41%, respectively, and together for more than a half (54%) of PAR for first incident AMI. Modifiable risk factors incorporating LSA and Lp(a) have accounted for an overwhelmingly large proportion of the risk of first incident AMI, indicating most first incident AMI is preventable. The knowledge of risk burdens for first incident AMI incorporating Lp (a) and LSA may be beneficial for further reducing first incident AMI from a new angle.
authors.affiliation: Division of Cardiology, Department of Medicine &Therapeutics, The Chinese University of Hong Kong, 30 Ngan Shing St, Shatin, New Territories, Hong Kong.
authors.forename: Qin
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Division of Cardiology, the First Affiliated Hospital of Soochow University, 188 Shizi Ave., Gusu District, Suzhou City, Jiangsu Province, 215006, P. R. China.
authors.forename: Yong-Ming
authors.initials: YM
authors.lastname: He
authors.affiliation: Healthcare Center for Shishan Street Community, Suzhou, 211 Yushan Rd., Huqiu District, Suzhou City, Jiangsu Province,215011, P. R. China.
authors.forename: Dong-Ping
authors.initials: DP
authors.lastname: Cai
authors.affiliation: Division of Cardiology, the First Affiliated Hospital of Soochow University, 188 Shizi Ave., Gusu District, Suzhou City, Jiangsu Province, 215006, P. R. China.
authors.forename: Xiang-Jun
authors.initials: XJ
authors.lastname: Yang
authors.affiliation: Division of Cardiology, the First Affiliated Hospital of Soochow University, 188 Shizi Ave., Gusu District, Suzhou City, Jiangsu Province, 215006, P. R. China.
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Xu
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D016022:Case-Control Studies; D016208:Databases, Factual; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000453:epidemiology*; D016017:Odds Ratio; D018570:Risk Assessment; D012307:Risk Factors; D012709:Serum Albumin; D012737:Sex Factors
chemical_list: D015415:Biomarkers; D017270:Lipoprotein(a); D012709:Serum Albumin