title: Pd-Catalyzed C(sp2)-H carbonylation of 2-benzylpyridines for the synthesis of pyridoisoquinolinones.
abstract: An efficient synthesis of pyridoisoquinolinones, through Pd-catalyzed carbonylative annulation of 2-benzylpyridines, has been developed. The pyridinyl moiety in the substrate acts as both a directing group and an internal nucleophile for sp2C-H activation and pyridocarbonylation. The ready availability of 2-benzylpyridines as well as the operational practicality makes this transformation potentially useful for the synthesis of analogues of protoberberine alkaloids.
authors.affiliation: State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, China. zhu_qiang@gibh.ac.cn luo_shuang@gibh.ac.cn.
authors.forename: Zeqiang
authors.initials: Z
authors.lastname: Xie
authors.affiliation: State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, China. zhu_qiang@gibh.ac.cn luo_shuang@gibh.ac.cn.
authors.forename: Shuang
authors.initials: S
authors.lastname: Luo
authors.affiliation: State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, China. zhu_qiang@gibh.ac.cn luo_shuang@gibh.ac.cn.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhu