title: Does significant renal ablation truly and invariably lead to hyperfiltration and progressive chronic kidney disease?
abstract: It is generally believed that significant renal ablation leads to hyperfiltration and eventually progressively worsening chronic kidney disease. The data behind this belief have not been scrutinized intensively. More importantly, the above belief leads many physicians to manage patients differently than they otherwise would manage. Here, we examine the data behind whether hyperfiltration occurs when patients lose kidney mass (by excision or by disease) and whether the hyperfiltration is uniformly injurious.
authors.affiliation: Division of Nephrology, San Francisco General Hospital, University of California, 1001 Potrero Ave, Building 100, Rm 342, San Francisco, CA, 94110-1341, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Wang
authors.affiliation: Division of Nephrology, San Francisco General Hospital, University of California, 1001 Potrero Ave, Building 100, Rm 342, San Francisco, CA, 94110-1341, USA. ramin.sam@ucsf.edu.
authors.forename: Ramin
authors.initials: R
authors.lastname: Sam
mesh_terms: D000818:Animals; D018450:Disease Progression; D005260:Female; D005355:Fibrosis; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery*; D008181:Lupus Nephritis / Q000150:complications* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D008875:Middle Aged; D009392:Nephrectomy / Q000009:adverse effects*; D011379:Prognosis; D011507:Proteinuria / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D012307:Risk Factors
keywords: Chronic kidney disease; Hyperfiltration; Renal ablation