title: The evolution of Ebola virus: Insights from the 2013-2016 epidemic.
abstract: The 2013-2016 epidemic of Ebola virus disease in West Africa was of unprecedented magnitude and changed our perspective on this lethal but sporadically emerging virus. This outbreak also marked the beginning of large-scale real-time molecular epidemiology. Here, we show how evolutionary analyses of Ebola virus genome sequences provided key insights into virus origins, evolution and spread during the epidemic. We provide basic scientists, epidemiologists, medical practitioners and other outbreak responders with an enhanced understanding of the utility and limitations of pathogen genomic sequencing. This will be crucially important in our attempts to track and control future infectious disease outbreaks.
authors.affiliation: Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and Sydney Medical School, Charles Perkins Centre, University of Sydney, Sydney, New South Wales 2006, Australia.
authors.forename: Edward C
authors.initials: EC
authors.lastname: Holmes
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.|Institute of Evolutionary Biology, Ashworth Laboratories, University of Edinburgh, Edinburgh EH9 3FL, UK.
authors.forename: Gytis
authors.initials: G
authors.lastname: Dudas
authors.affiliation: Institute of Evolutionary Biology, Ashworth Laboratories, University of Edinburgh, Edinburgh EH9 3FL, UK.|Centre for Immunology, Infection and Evolution, University of Edinburgh, Ashworth Laboratories, Edinburgh EH9 3FL, UK.|Fogarty International Center, National Institutes of Health, MSC 2220 Bethesda, Maryland 20892, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Rambaut
authors.affiliation: The Scripps Research Institute, Department of Immunology and Microbial Science, La Jolla, San Diego, California 92037, USA.|The Scripps Research Institute, Department of Integrative Structural and Computational Biology, La Jolla, San Diego, California 92037, USA.|Scripps Translational Science Institute, La Jolla, San Diego, California 92037, USA.
authors.forename: Kristian G
authors.initials: KG
authors.lastname: Andersen
mesh_terms: D000818:Animals; D029043:Ebolavirus / Q000145:classification / Q000235:genetics*; D019143:Evolution, Molecular; D016679:Genome, Viral / Q000235:genetics; D019142:Hemorrhagic Fever, Ebola / Q000453:epidemiology* / Q000821:virology*; D006801:Humans; D017720:Molecular Epidemiology; D010641:Phenotype; D011634:Public Health