title: Association between olfactory identification and cognitive function in community-dwelling elderly: the Shanghai aging study.
abstract: BACKGROUND
  The smell sense reduction was considered to represent the potentially warning of early stage of neurodegenerative disorders. The Shanghai Aging Study provided us a unique opportunity to explore the association between olfactory identification (OI) and cognitive function among community-dwelling elderly in China.
  
  
  METHODS
  OI of each participant was measured by the 12-item identification tests from Sniffin' Sticks Screening test (SSST-12). Participants with mild cognitive impairment (MCI) were diagnosed by Petersen criteria. We used the logistic regression analysis to explore the association between OI scores and cognitive function by adjusting potential confounders.
  
  
  RESULTS
  Among 1782 non-demented participants, 345 (19.4 %) participants were diagnosed as MCI. The mean OI score for participants with MCI [7.1 (SD 2.3)] was significantly lower than that for those with normal cognition [8.2 (SD 2.0), P < 0.0001]. After adjusted for age, gender, education, lifestyles, medical history, Apolipoprotein E genotype, lower OI score was found to be an independent influence factor related to MCI (OR 1.19, 95 % CI 1.11-1.27).
  
  
  CONCLUSIONS
  Our study suggests that poor OI may be associated with MCI in elderly population. Further prospective studies may confirm the OI as a reliable and early marker predicting the decline of cognitive function.
authors.affiliation: Institute of Neurology, Huashan Hospital, Fudan University, WHO Collaborating Center for Research and Training in Neurosciences, Shanghai, 200040, China.|Department of Biostatistics, School of Public Health, Fudan University, Shanghai, 200032, China.|The Key Laboratory of Public Health Safety, Fudan University, Shanghai, 200032, China.|National Clinical Research Center for Aging Diseases, Shanghai, 200040, China.
authors.forename: Xiaoniu
authors.initials: X
authors.lastname: Liang
authors.affiliation: Institute of Neurology, Huashan Hospital, Fudan University, WHO Collaborating Center for Research and Training in Neurosciences, Shanghai, 200040, China. dding99@163.com.|National Clinical Research Center for Aging Diseases, Shanghai, 200040, China. dding99@163.com.
authors.forename: Ding
authors.initials: D
authors.lastname: Ding
authors.affiliation: Institute of Neurology, Huashan Hospital, Fudan University, WHO Collaborating Center for Research and Training in Neurosciences, Shanghai, 200040, China.|National Clinical Research Center for Aging Diseases, Shanghai, 200040, China.
authors.forename: Qianhua
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Institute of Neurology, Huashan Hospital, Fudan University, WHO Collaborating Center for Research and Training in Neurosciences, Shanghai, 200040, China.|National Clinical Research Center for Aging Diseases, Shanghai, 200040, China.
authors.forename: Qihao
authors.initials: Q
authors.lastname: Guo
authors.affiliation: Department of Biostatistics, School of Public Health, Fudan University, Shanghai, 200032, China.|The Key Laboratory of Public Health Safety, Fudan University, Shanghai, 200032, China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Luo
authors.affiliation: Institute of Neurology, Huashan Hospital, Fudan University, WHO Collaborating Center for Research and Training in Neurosciences, Shanghai, 200040, China.|National Clinical Research Center for Aging Diseases, Shanghai, 200040, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Hong
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D002681:China / Q000453:epidemiology; D060825:Cognitive Dysfunction / Q000453:epidemiology*; D015897:Comorbidity; D005260:Female; D006801:Humans; D057187:Independent Living; D008297:Male; D008875:Middle Aged; D000857:Olfaction Disorders / Q000453:epidemiology*
keywords: Community-based study; Elderly; Mild cognitive impairment; Olfactory identification