title: USPIO size control through microwave nonaqueous sol-gel method for neoangiogenesis T2MRI contrast agent.
abstract: OBJECTIVE
  Tunable size ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles from 3 to 9 nm coated with polyethylene glycol phosphonate moieties have been designed for neovascularization MRI.
  
  
  METHODS
  USPIO were synthesized using a nonaqueous sol-gel method. An ischemia-reperfusion rat model has been chosen for neo-angiogenesis and scanned on MRI after injection of different sized USPIO. Histological studies have been performed for USPIO localization within the tissue.
  
  
  RESULTS
  The magnetic properties and consequently their MRI relaxivities are drastically dependent on the crystalline core size. In vivo MRI spots were observed specifically in the ischemic area. The best MRI contrast within neovascularization is generated by 6 nm nanoparticles proving that compromise between T2relaxivity and physico-chemical properties is essential for the design of effective MRI contrast agent.
authors.affiliation: Laboratoire CSPBAT, CNRS UMR 7244, UFR SMBH, Université Paris 13, Sorbonne Paris Cité, F-93017 Bobigny, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Richard
authors.affiliation: Inserm, U1148, Laboratory for Vascular Translational Science, UFR SMBH, Université Paris 13, Sorbonne Paris Cité, 74 rue M. Cachin, F-93017 Bobigny, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Eder
authors.affiliation: Istituto Italiano di Tecnologia (IIT), Smart Materials, Department of Nanophysics, Via Morego 30, 16163 Genova, Italia.|Inserm, U1148, Laboratory for Vascular Translational Science, Plateforme de Recherche FRIM, Université Paris 7, Sorbonne Paris Cité, CHU X Bichat, 46 rue H. Huchard, F-75877 Paris, France.
authors.forename: Gianvito
authors.initials: G
authors.lastname: Caputo
authors.affiliation: Department of Chemistry, Humboldt-Universität zu Berlin, Brook-Taylor-Straße 2, 12489 Berlin, Germany.
authors.forename: Clément
authors.initials: C
authors.lastname: Journé
authors.affiliation: Department of Chemistry, Humboldt-Universität zu Berlin, Brook-Taylor-Straße 2, 12489 Berlin, Germany.
authors.forename: Phalla
authors.initials: P
authors.lastname: Ou
authors.affiliation: Laboratoire CSPBAT, CNRS UMR 7244, UFR SMBH, Université Paris 13, Sorbonne Paris Cité, F-93017 Bobigny, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Bolley
authors.affiliation: Department of Chemistry, Humboldt-Universität zu Berlin, Brook-Taylor-Straße 2, 12489 Berlin, Germany.
authors.forename: Liliane
authors.initials: L
authors.lastname: Louedec
authors.affiliation: Inserm, U1148, Laboratory for Vascular Translational Science, UFR SMBH, Université Paris 13, Sorbonne Paris Cité, 74 rue M. Cachin, F-93017 Bobigny, France.
authors.forename: Erwann
authors.initials: E
authors.lastname: Guenin
authors.affiliation: Inserm, U1148, Laboratory for Vascular Translational Science, UFR SMBH, Université Paris 13, Sorbonne Paris Cité, 74 rue M. Cachin, F-93017 Bobigny, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Motte
authors.affiliation: Inserm, U1148, Laboratory for Vascular Translational Science, Plateforme de Recherche FRIM, Université Paris 7, Sorbonne Paris Cité, CHU X Bichat, 46 rue H. Huchard, F-75877 Paris, France.
authors.forename: Nicola
authors.initials: N
authors.lastname: Pinna
authors.affiliation: Inserm, U1148, Laboratory for Vascular Translational Science, UFR SMBH, Université Paris 13, Sorbonne Paris Cité, 74 rue M. Cachin, F-93017 Bobigny, France.|Service de Médecine Nucléaire, Hôpital Avicenne Assistance Publique-Hôpitaux de Paris F-93009 Bobigny, France.
authors.forename: Yoann
authors.initials: Y
authors.lastname: Lalatonne
keywords: MRI; USPIO; angiogenesis; ischemia; nanoparticles; neovascularization