title: Unfolded protein response in brain ischemia: A timely update.
abstract: Folding and processing newly synthesized proteins are vital functions of the endoplasmic reticulum that are sensitive to a variety of stress conditions. The unfolded protein response is activated to restore endoplasmic reticulum function impaired by stress. While we know that brain ischemia impairs endoplasmic reticulum function, the role of unfolded protein response activation in post-ischemic recovery of neurologic function is only beginning to emerge. Here, we summarize what is known about endoplasmic reticulum stress and unfolded protein response in brain ischemia and discuss recent findings from myocardial ischemia studies that could help to advance research on endoplasmic reticulum stress and unfolded protein response in brain ischemia.
authors.affiliation: Department of Anesthesiology, Duke University Medical Center, Durham, USA wei.yang@duke.edu wulf.paschen@duke.edu.
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
authors.affiliation: Department of Anesthesiology, Duke University Medical Center, Durham, USA.|Department of Neurobiology, Duke University Medical Center, Durham, USA.
authors.forename: Wulf
authors.initials: W
authors.lastname: Paschen
mesh_terms: D002545:Brain Ischemia / Q000473:pathology*; D059865:Endoplasmic Reticulum Stress; D006801:Humans; D020127:Recovery of Function; D056811:Unfolded Protein Response / Q000502:physiology*
keywords: Brain ischemia; endoplasmic reticulum; myocardial ischemia; stroke; unfolded protein response