title: Lower Body Mass Index is a Risk Factor for In-Hospital Mortality of Elderly Japanese Patients Treated with Ampicillin/sulbactam.
abstract: Objectives:A retrospective examination was conducted to identify risk factors for in-hospital mortality of elderly patients (65 years or older) treated with the beta-lactam/beta-lactamase inhibitor combination antibiotic, ampicillin/sulbactam (ABPC/SBT).Methods:Clinical data from 96 patients who were hospitalized with infectious diseases and treated with ABPC/SBT (9 g/day or 12 g/day) were analyzed. Risk factors examined included demographic and clinical laboratory parameters. Parameter values prior to treatment and changes after treatment were compared between survivors and non-survivors.Results:The study patients had an average age of 81.9±8.4 years (±SD) and body mass index (BMI) of 19.9±4.2 kg/m2. They were characterized by anemia (low hemoglobin and hematocrit levels), inflammation (high leukocyte count, neutrophil count, C-reactive protein level, and body temperature), and hepatic and renal dysfunction (high aspartate aminotransferase, alanine aminotransferase and blood urea nitrogen levels). The BMI of non-survivors, 16.2±2.9 kg/m2, was lower than that of survivors, 20.4±4.1 kg/m2. In addition, the hematological parameters deteriorated more remarkably, inflammation markers were not altered (or the decrease was marginal), and hepatic function was not improved, in non-survivors.Conclusions:A lower BMI value is a risk factor for in-hospital mortality of elderly patients treated with ABPC/SBT.
authors.affiliation: Department of Pharmacy, Rakuwakai Otowa Hospital, Kyoto 607-8062, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Miura
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya 663-8179, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Kuwahara
authors.affiliation: Department of Pharmacy, Kyoto Kujo Hospital, Kyoto 601-8453, Japan.
authors.forename: Akinori
authors.initials: A
authors.lastname: Tomozawa
authors.affiliation: Department of Pharmacy, Rakuwakai Marutamachi Hospital, Kyoto 604-8405, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Omae
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya 663-8179, Japan.
authors.forename: Motohiro
authors.initials: M
authors.lastname: Yamamori
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Kadoyama
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan;; Department of Pharmacokinetics, Kyoto Pharmaceutical University, Kyoto 607-8414, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Sakaeda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000097:blood; D000667:Ampicillin / Q000008:administration & dosage / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001219:Aspartate Aminotransferases / Q000097:blood; D001424:Bacterial Infections / Q000097:blood / Q000188:drug therapy / Q000401:mortality*; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D004338:Drug Combinations; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007958:Leukocyte Count; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D013407:Sulbactam / Q000008:administration & dosage / Q000627:therapeutic use; D014508:Urea / Q000097:blood
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; C035444:sultamicillin; D000667:Ampicillin; D014508:Urea; D002097:C-Reactive Protein; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D013407:Sulbactam
keywords: ampicillin/sulbactam; body mass index.; elderly patients; mortality