title: Interventional treatments for Hailey-Hailey disease.
abstract: Hailey-Hailey disease or familial benign chronic pemphigus is a rare blistering dermatosis that is characterized by recurrent erythematous plaques with a predilection for the skin folds. For extensive Hailey-Hailey disease that is recalcitrant to conventional therapy, laser ablation, photodynamic therapy, electron beam radiotherapy, botulinum toxin type A, dermabrasion, glycopyrrolate, and afamelanotide have been reported as useful treatments, but comparative trials are lacking. This review discusses the various treatment modalities for Hailey-Hailey disease and a summary of the evidence for the most recommended treatments.
authors.affiliation: Department of Dermatology, University of Vermont, Burlington, Vermont.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Farahnik
authors.affiliation: Department of Dermatology, Silver Falls Dermatology, Salem, Oregon. Electronic address: collin.blattner@gmail.com.
authors.forename: Collin M
authors.initials: CM
authors.lastname: Blattner
authors.affiliation: Department of Dermatologic Surgery, Skin Cancer Treatment Center, Santa Monica, California.
authors.forename: Michael B
authors.initials: MB
authors.lastname: Mortazie
authors.affiliation: Department of Dermatology, Silver Falls Dermatology, Salem, Oregon.
authors.forename: Benjamin M
authors.initials: BM
authors.lastname: Perry
authors.affiliation: Department of Dermatology and Dermatologic Surgery, Silver Falls Dermatology, Salem, Oregon.
authors.forename: William
authors.initials: W
authors.lastname: Lear
authors.affiliation: Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina.
authors.forename: Dirk M
authors.initials: DM
authors.lastname: Elston
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use; D017115:Catheter Ablation; D003869:Dermabrasion; D006024:Glycopyrrolate / Q000627:therapeutic use; D006801:Humans; D053685:Laser Therapy; D018727:Muscarinic Antagonists / Q000627:therapeutic use; D009498:Neurotoxins / Q000627:therapeutic use; D016506:Pemphigus, Benign Familial / Q000628:therapy*; D010778:Photochemotherapy; D011878:Radiotherapy; D000521:alpha-MSH / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D018727:Muscarinic Antagonists; D009498:Neurotoxins; D000521:alpha-MSH; D019274:Botulinum Toxins, Type A; C534526:afamelanotide; D006024:Glycopyrrolate
keywords: Hailey-Hailey disease; botulinum toxin type A; familial benign chronic pemphigus; interventional treatments; laser ablation; recalcitrant Hailey-Hailey disease