title: Ultra-High-Field Magnetic Resonance Imaging of the Human Inner Ear at 11.7 Tesla.
abstract: To evaluate the ability of ultra-high-field magnetic resonance imaging (UHF-MRI) at 11.7 T to visualize membranous structures of the human inner ear.
  
  
  
  Three temporal bones were extracted from cadaveric human heads for use with small-bore UHF-MRI.
  
  
  
  Ex vivo cadaveric temporal bone specimens were imaged using an 11.7 T magnetic resonance imaging (MRI) scanner via T1- and T2-weighted-imaging with and without contrast.
  
  
  
  Qualitative visualization of membranous components of the inner ear compared with reports of UHF-MRI at lower field strengths.
  
  
  
  The membranous anatomy of the inner ear was superbly visualized at 11.7 T. In the cochlea, Reissner's membrane, the scala media, and the basilar membrane were clearly shown on the scan. In the vestibular labyrinth, the wedge-shaped crista ampullaris and the maculae of both the saccule and utricle were visible. Details of the endolymphatic sac and duct were also demonstrated.
  
  
  
  To our knowledge, this report presents the first images of the ex vivo human inner ear using 11.7 T UHF-MRI, offering near-histologic resolution. Increased field strength may be particularly useful when imaging the delicate membranous anatomy of the inner ear. Further research on the use of UHF-MRI in clinical and research settings could illuminate structural changes associated with inner ear disorders.
authors.affiliation: *USC Tina and Rick Caruso Department of Otolaryngology-Head & Neck Surgery †Biological Imaging Center, Beckman Institute, California Institute of Technology, Pasadena ‡Department of Radiology §Laboratory of Neuro Imaging, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California.
authors.forename: David S
authors.initials: DS
authors.lastname: Thylur
authors.forename: Russell E
authors.initials: RE
authors.lastname: Jacobs
authors.forename: John L
authors.initials: JL
authors.lastname: Go
authors.forename: Arthur W
authors.initials: AW
authors.lastname: Toga
authors.forename: John K
authors.initials: JK
authors.lastname: Niparko
mesh_terms: D007758:Ear, Inner / Q000033:anatomy & histology* / Q000000981:diagnostic imaging*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*