title: Role of microRNAs on the Regulation of Mitochondrial Biogenesis and Insulin Signaling in Skeletal Muscle.
abstract: Mitochondria play a critical role in several cellular processes and cellular homeostasis. Mitochondrion dysfunction has been correlated with numerous metabolic diseases such as obesity and type 2 diabetes. MicroRNAs are non-coding RNAs that have emerged as key regulators of cell metabolism. The microRNAs act as central regulators of metabolic gene networks by leading to the degradation of their target messenger RNA or repression of protein translation. In addition, vesicular and non-vesicular circulating miRNAs exhibit a potential role as mediators of the cross-talk between the skeletal muscle and other tissues/organs. In this review, we will focus on the emerging knowledge of miRNAs controlling mitochondrial function and insulin signaling in skeletal muscle cells. J. Cell. Physiol. 232: 958-966, 2017. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Obesity and Comorbidities Research Center, Department of Structural and Functional Biology, Institute of Biology, Unicamp, Campinas, SP, Brazil.|Ribeirão Preto Medical School, Department of Biochemistry and Immunology, USPRP, Ribeirão Preto, SP, Brazil.
authors.forename: Tanes I
authors.initials: TI
authors.lastname: Lima
authors.affiliation: Obesity and Comorbidities Research Center, Department of Structural and Functional Biology, Institute of Biology, Unicamp, Campinas, SP, Brazil.
authors.forename: Hygor N
authors.initials: HN
authors.lastname: Araujo
authors.affiliation: Obesity and Comorbidities Research Center, Department of Structural and Functional Biology, Institute of Biology, Unicamp, Campinas, SP, Brazil.
authors.forename: Eveline S
authors.initials: ES
authors.lastname: Menezes
authors.affiliation: Obesity and Comorbidities Research Center, Department of Structural and Functional Biology, Institute of Biology, Unicamp, Campinas, SP, Brazil.
authors.forename: Carlos H
authors.initials: CH
authors.lastname: Sponton
authors.affiliation: Obesity and Comorbidities Research Center, Department of Structural and Functional Biology, Institute of Biology, Unicamp, Campinas, SP, Brazil.
authors.forename: Michel B
authors.initials: MB
authors.lastname: Araújo
authors.affiliation: Obesity and Comorbidities Research Center, Department of Structural and Functional Biology, Institute of Biology, Unicamp, Campinas, SP, Brazil.
authors.forename: Lucas H M
authors.initials: LH
authors.lastname: Bomfim
authors.affiliation: Ribeirão Preto Medical School, Department of Biochemistry and Immunology, USPRP, Ribeirão Preto, SP, Brazil.
authors.forename: André L
authors.initials: AL
authors.lastname: Queiroz
authors.affiliation: Ribeirão Preto Medical School, Department of Biochemistry and Immunology, USPRP, Ribeirão Preto, SP, Brazil.
authors.forename: Madla A
authors.initials: MA
authors.lastname: Passos
authors.affiliation: Federal Institute of Goiás, Formosa Campus, Goiás, Brazil.
authors.forename: Thais Amaral
authors.initials: TA
authors.lastname: E Sousa
authors.affiliation: Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, São Paulo, SP, Brazil.
authors.forename: Sandro M
authors.initials: SM
authors.lastname: Hirabara
authors.affiliation: Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
authors.forename: Amanda R
authors.initials: AR
authors.lastname: Martins
authors.affiliation: Obesity and Comorbidities Research Center, Department of Structural and Functional Biology, Institute of Biology, Unicamp, Campinas, SP, Brazil.
authors.forename: Helena C L B
authors.initials: HC
authors.lastname: Sampaio
authors.affiliation: Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
authors.forename: Alice
authors.initials: A
authors.lastname: Rodrigues
authors.affiliation: Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
authors.forename: Rui
authors.initials: R
authors.lastname: Curi
authors.affiliation: Obesity and Comorbidities Research Center, Department of Structural and Functional Biology, Institute of Biology, Unicamp, Campinas, SP, Brazil.
authors.forename: Everardo M
authors.initials: EM
authors.lastname: Carneiro
authors.affiliation: Obesity and Comorbidities Research Center, Department of Structural and Functional Biology, Institute of Biology, Unicamp, Campinas, SP, Brazil.
authors.forename: Antônio C
authors.initials: AC
authors.lastname: Boschero
authors.affiliation: Obesity and Comorbidities Research Center, Department of Structural and Functional Biology, Institute of Biology, Unicamp, Campinas, SP, Brazil.
authors.forename: Leonardo R
authors.initials: LR
authors.lastname: Silveira
mesh_terms: D006801:Humans; D007328:Insulin / Q000378:metabolism*; D035683:MicroRNAs / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism*; D001678:Organelle Biogenesis; D015398:Signal Transduction
chemical_list: D007328:Insulin; D035683:MicroRNAs