title: Association between uterine artery Doppler blood flow changes and arterial wall elasticity in pregnant women.
abstract: BACKGROUND
  Uterine artery (UtA) Doppler velocimetry changes and increased arterial stiffness are associated with preeclampsia. We aimed to investigate the relation between UtA velocimetry changes and arterial stiffness in pregnant women.
  
  
  METHODS
  Doppler velocimetry and photoplethysmographic digital pulse wave analysis (DPA) were performed in 173 pregnant women in the second or the third trimester, where UtA Doppler pulsatility index (PI), diastolic notching, and UtA score (UAS) combining notching and high PI were calculated. DPA stiffness parameters representing large arteries were ejection elasticity index (EEI) and b/a, small arteries dicrotic index (DI) and d/a, and global stiffness the aging index (AI).
  
  
  RESULTS
  One hundred and thirty women had normal Doppler and 43 had diastolic notching, of whom nine had high PI. DI indicated increased stiffness in small arteries when notching was present (p = 0.044) and showed a significant but weak correlation to UAS (p = 0.025, tau 0.12). EEI and b/a indicated increased large artery stiffness (p ≤0.014), d/a small artery stiffness (p = 0.023), and AI a systemic stiffness (p = 0.040) when high PI.
  
  
  CONCLUSIONS
  High UtA PI was associated with increased systemic arterial stiffness, whereas notching was related to increased stiffness in small arteries only. This indicates pathophysiological differences between the two Doppler parameters.
authors.affiliation: a Department of Obstetrics and Gynecology , Institution of Clinical Sciences, Skåne University Hospital, Lund University , Malmö , Sweden.
authors.forename: Emma
authors.initials: E
authors.lastname: von Wowern
authors.affiliation: a Department of Obstetrics and Gynecology , Institution of Clinical Sciences, Skåne University Hospital, Lund University , Malmö , Sweden.
authors.forename: Jakob
authors.initials: J
authors.lastname: Andersson
authors.affiliation: a Department of Obstetrics and Gynecology , Institution of Clinical Sciences, Skåne University Hospital, Lund University , Malmö , Sweden.
authors.forename: Ida Dalene
authors.initials: ID
authors.lastname: Skarping
authors.affiliation: a Department of Obstetrics and Gynecology , Institution of Clinical Sciences, Skåne University Hospital, Lund University , Malmö , Sweden.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Howie
authors.affiliation: a Department of Obstetrics and Gynecology , Institution of Clinical Sciences, Skåne University Hospital, Lund University , Malmö , Sweden.
authors.forename: Per
authors.initials: P
authors.lastname: Olofsson
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D004548:Elasticity; D054459:Elasticity Imaging Techniques; D005260:Female; D006801:Humans; D011247:Pregnancy / Q000502:physiology*; D012039:Regional Blood Flow; D012212:Rheology; D016216:Ultrasonography, Prenatal; D055988:Uterine Artery / Q000502:physiology*; D059289:Vascular Stiffness; D055815:Young Adult
keywords: Arterial stiffness; diastolic notching; photoplethysmography; pregnancy; pulsatility index