title: Patterns of antimicrobial resistance in lesions of hidradenitis suppurativa.
abstract: BACKGROUND
  Antibiotic therapy is commonly used to treat hidradenitis suppurativa (HS). Although concern for antibiotic resistance exists, data examining the association between antibiotics and antimicrobial resistance in HS lesions are limited.
  
  
  OBJECTIVE
  We sought to determine the frequency of antimicrobial resistance in HS lesions from patients on antibiotic therapy.
  
  
  METHODS
  A cross-sectional analysis was conducted on 239 patients with HS seen at the Johns Hopkins Medical Institutions from 2010 through 2015.
  
  
  RESULTS
  Patients using topical clindamycin were more likely to grow clindamycin-resistant Staphylococcus aureus compared with patients using no antibiotics (63% vs 17%; P = .03). Patients taking ciprofloxacin were more likely to grow ciprofloxacin-resistant methicillin-resistant S aureus compared with patients using no antibiotics (100% vs 10%; P = .045). Patients taking trimethoprim/sulfamethoxazole were more likely to grow trimethoprim/sulfamethoxazole-resistant Proteus species compared with patients using no antibiotics (88% vs 0%; P < .001). No significant antimicrobial resistance was observed with tetracyclines or oral clindamycin.
  
  
  CONCLUSIONS
  Data on disease characteristics and antimicrobial susceptibilities for certain bacteria were limited.
  
  
  CONCLUSIONS
  Antibiotic therapy for HS treatment may be inducing antibiotic resistance. These findings highlight the importance of stewardship in antibiotic therapy for HS and raise questions regarding the balance of antibiotic use versus potential harms associated with antibiotic resistance.
authors.affiliation: Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address: afisch11@jhmi.edu.
authors.forename: Alexander H
authors.initials: AH
authors.lastname: Fischer
authors.affiliation: Howard University College of Medicine, Washington, District of Columbia.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Haskin
authors.affiliation: Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Ginette A
authors.initials: GA
authors.lastname: Okoye
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D024881:Drug Resistance, Bacterial; D005260:Female; D017497:Hidradenitis Suppurativa / Q000188:drug therapy* / Q000382:microbiology*; D006801:Humans; D008297:Male
chemical_list: D000900:Anti-Bacterial Agents
keywords: acne inversa; antibiotics; antimicrobial resistance; hidradenitis suppurativa