title: Studies of the Transmission Dynamics, Mathematical Model Development and the Control of Schistosome Parasites by Mass Drug Administration in Human Communities.
abstract: Schistosomiasis is global in extent within developing countries, but more than 90% of the at-risk population lives in sub-Saharan Africa. In total, 261 million people are estimated to require preventive treatment. However, with increasing drug availability through donation, the World Health Organization has set a goal of increasing coverage to 75% of at-risk children in endemic countries and elimination in some regions. In this chapter, we discuss key biological and epidemiological processes involved in the schistosome transmission cycle and review the history of modelling schistosomiasis and the impact of mass drug administration, including both deterministic and stochastic approaches. In particular, we look at the potential impact of the WHO 2020 schistosomiasis treatment goals.
authors.affiliation: London Centre for Neglected Tropical Disease Research, London, United Kingdom.
authors.forename: R M
authors.initials: RM
authors.lastname: Anderson
authors.affiliation: London Centre for Neglected Tropical Disease Research, London, United Kingdom.
authors.forename: H C
authors.initials: HC
authors.lastname: Turner
authors.affiliation: London Centre for Neglected Tropical Disease Research, London, United Kingdom.
authors.forename: S H
authors.initials: SH
authors.lastname: Farrell
authors.affiliation: London Centre for Neglected Tropical Disease Research, London, United Kingdom.
authors.forename: J E
authors.initials: JE
authors.lastname: Truscott
mesh_terms: D017954:Africa South of the Sahara / Q000453:epidemiology; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage*; D060740:Disease Eradication; D006801:Humans; D008962:Models, Theoretical; D012547:Schistosoma / Q000187:drug effects* / Q000502:physiology; D012552:Schistosomiasis / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission
chemical_list: D000871:Anthelmintics
keywords: Elimination; Mass drug administration; Modelling; Schistosomiasis