title: Value of volume-based metabolic parameters for predicting survival in breast cancer patients treated with neoadjuvant chemotherapy.
abstract: We evaluated the role of metabolic parameters in the prediction of disease recurrence in operable invasive ductal breast cancer patients treated with neoadjuvant chemotherapy (NAC).We retrospectively evaluated 139 female patients (mean age, 46.5 years; range: 27-72 years) with invasive ductal breast cancer, treated with NAC followed by surgery. All patients underwent F-fluorodeoxyglucose positron emission tomography/computed tomography and magnetic resonance imaging at baseline and after completion of NAC before surgery. The prognostic significance of clinicopathological and imaging parameters for disease-free survival (DFS) was evaluated.Recurrence of cancer was detected in 31 of 139 patients (22.3%; follow-up period: 6-82 months). Baseline maximum standardized uptake value, metabolic tumor volume (MTV), and reduction rate (RR) of MTV after NAC were significant independent prognostic factors for DFS in a multivariate analysis (all P < 0.05). The survival functions differed significantly between low and high histological grades (P < 0.001). DFS of the patients with high baseline MTV (≥5.23 cm) was significantly poorer than that of low MTV patients (P = 0.019). The survival function of the group with low RR of MTV after NAC (≤90.72%) was poorer than the higher RR of the MTV group (P = 0.008).Our findings suggest that breast cancer patients who have a high histological grade, large baseline MTV, or a small RR of MTV after NAC should receive great attention to check for possible recurrence.
authors.affiliation: Department of Radiology Department of Nuclear Medicine and Molecular Imaging Department of Hematology-Oncology Department of Surgery Department of Pathology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Tae Hee
authors.initials: TH
authors.lastname: Kim
authors.forename: Joon-Kee
authors.initials: JK
authors.lastname: Yoon
authors.forename: Doo Kyoung
authors.initials: DK
authors.lastname: Kang
authors.forename: Seok Yun
authors.initials: SY
authors.lastname: Kang
authors.forename: Yong Sik
authors.initials: YS
authors.lastname: Jung
authors.forename: Sehwan
authors.initials: S
authors.lastname: Han
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Hyunee
authors.initials: H
authors.lastname: Yim
authors.forename: Young-Sil
authors.initials: YS
authors.lastname: An
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D049268:Positron-Emission Tomography / Q000379:methods*; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D014057:Tomography, X-Ray Computed / Q000379:methods*; D047368:Tumor Burden
chemical_list: D000970:Antineoplastic Agents