title: Selesconol, a Fungal Polyketide That Induces Stem Cell Differentiation.
abstract: Owing to the negligible or acceptable immunogenicity, small molecules capable of inducing the differentiation of undifferentiated stem cells into organ-specific cell types are particularly promising in developing replacement therapy, but such compounds with undescribed architectures are extremely rare. Selesconol (1) is discovered from the culture of Daldinia eschscholzii IFB-TL01 as a skeletally unprecedented inducer for the differentiation of rat bone marrow mesenchymal stem cells into neural cells, with its unique framework clarified to derive from the intermediate tautomerization of the dalesconol A biosynthetic pathway.
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing 210093, China.
authors.forename: Ai Hua
authors.initials: AH
authors.lastname: Zhang
authors.affiliation: College of Medicine, Southwest Jiaotong University , Chengdu 610031, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Tan
authors.affiliation: School of Pharmacy, Nanjing Medical University , Nanjing 210029, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Jiang
authors.affiliation: College of Medicine, Southwest Jiaotong University , Chengdu 610031, China.
authors.forename: Kaidiriye
authors.initials: K
authors.lastname: Yusupu
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing 210093, China.|State Key Laboratory of Elemento-organic Chemistry, Nankai University , Tianjin 300071, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing 210093, China.
authors.forename: Xin Lei
authors.initials: XL
authors.lastname: Wang
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing 210093, China.
authors.forename: Ren Xiang
authors.initials: RX
authors.lastname: Tan
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D015394:Molecular Structure; D061065:Polyketides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013098:Xylariales / Q000737:chemistry* / Q000378:metabolism
chemical_list: D061065:Polyketides; C000627559:selesconol