title: Synthesis of a trimannosylated-equipped archaeal diether lipid for the development of novel glycoliposomes.
abstract: An archaeal diether lipid possessing a tri-antenna of α-D-mannopyranoside linked via an oligoethylene spacer to a (2S)-2-(phytanyloxy)-3-(hexadecyloxy)propanoic acid backbone (TriMan-Diether) was designed and synthesized. This new mannosylated lipid inserted in liposomes would show both DC-targeting and adjuvant properties thanks to the TriMan structure and the diether tail part, respectively.
authors.affiliation: Ecole Nationale Supérieure de Chimie de Rennes, CNRS UMR 6226, 11 Allée de Beaulieu, CS 50837, 35708 Rennes Cedex 7, France; Université de Bretagne Loire, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Barbeau
authors.affiliation: Ecole Nationale Supérieure de Chimie de Rennes, CNRS UMR 6226, 11 Allée de Beaulieu, CS 50837, 35708 Rennes Cedex 7, France; Université de Bretagne Loire, France.
authors.forename: Loïc
authors.initials: L
authors.lastname: Lemiègre
authors.affiliation: Ecole Nationale Supérieure de Chimie de Rennes, CNRS UMR 6226, 11 Allée de Beaulieu, CS 50837, 35708 Rennes Cedex 7, France; Université de Bretagne Loire, France.
authors.forename: Allan
authors.initials: A
authors.lastname: Quelen
authors.affiliation: Centre de Biophysique Moléculaire, CNRS UPR 4301, Université d'Orléans, rue Charles Sadron, CS 80054, 45071 Orléans, France.
authors.forename: Virginie
authors.initials: V
authors.lastname: Malard
authors.affiliation: Centre de Biophysique Moléculaire, CNRS UPR 4301, Université d'Orléans, rue Charles Sadron, CS 80054, 45071 Orléans, France.
authors.forename: Haifei
authors.initials: H
authors.lastname: Gao
authors.affiliation: Centre de Biophysique Moléculaire, CNRS UPR 4301, Université d'Orléans, rue Charles Sadron, CS 80054, 45071 Orléans, France.
authors.forename: Cristine
authors.initials: C
authors.lastname: Gonçalves
authors.affiliation: CEMCA, CNRS UMR 6521, SFR148 ScInBioS, Université de Brest, Brest, France; Université de Bretagne Loire, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Berchel
authors.affiliation: CEMCA, CNRS UMR 6521, SFR148 ScInBioS, Université de Brest, Brest, France; Université de Bretagne Loire, France.
authors.forename: Paul-Alain
authors.initials: PA
authors.lastname: Jaffrès
authors.affiliation: Centre de Biophysique Moléculaire, CNRS UPR 4301, Université d'Orléans, rue Charles Sadron, CS 80054, 45071 Orléans, France.
authors.forename: Chantal
authors.initials: C
authors.lastname: Pichon
authors.affiliation: Centre de Biophysique Moléculaire, CNRS UPR 4301, Université d'Orléans, rue Charles Sadron, CS 80054, 45071 Orléans, France. Electronic address: patrick.midoux@cnrs-orleans.fr.
authors.forename: Patrick
authors.initials: P
authors.lastname: Midoux
authors.affiliation: Ecole Nationale Supérieure de Chimie de Rennes, CNRS UMR 6226, 11 Allée de Beaulieu, CS 50837, 35708 Rennes Cedex 7, France; Université de Bretagne Loire, France. Electronic address: thierry.benvegnu@ensc-rennes.fr.
authors.forename: Thierry
authors.initials: T
authors.lastname: Benvegnu
mesh_terms: D001105:Archaea / Q000737:chemistry*; D008055:Lipids / Q000138:chemical synthesis* / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry; D008358:Mannose / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D008055:Lipids; D008081:Liposomes; D008358:Mannose
keywords: Archaeal trimannosyl lipid; Dendritic cell binding; Liposomes; Mannose receptor