title: Serum soluble urokinase-type plasminogen activator receptor as a serum marker of inflammatory response that leads to tissue damage and surgical complication.
abstract: Unrestrained activation of the proteolytic systems in anastomotic tissue during repair has been implicated in the pathogenesis of anastomotic leakage. We hypothesized that this mechanism may promote an up-regulation of the urokinase-type plasminogen activator system and a spillover of soluble urokinase-type plasminogen activator receptor (suPAR) into blood. In this retrospective analysis patients with anastomotic leakage were compared with a group of matched uncomplicated patients. Anastomotic leakage complicated patients had significantly higher suPAR (p = 0.04) levels until day 3 after surgery. The area under the receiver-operating characteristic (ROC) for suPAR was higher than that CRP (0.874 vs. 0.836). Their analysis suggests the possible use of suPAR as serum marker to characterize the persistent inflammatory response that lead to tissue damage and surgical complication.
authors.affiliation: Department of Anesthesia, Intensive Care and Palliative Care, Istituto Nazionale Tumori, IRCCS Foundation.
authors.forename: Emiliano
authors.initials: E
authors.lastname: Tognoli
authors.affiliation: Department of Anesthesia, Intensive Care and Palliative Care, Istituto Nazionale Tumori, IRCCS Foundation.|Department of Pathophysiology and Transplantation, University of Milan.
authors.forename: Matteo
authors.initials: M
authors.lastname: Luigi Giuseppe Leoni
authors.affiliation: Department of Pathology and Laboratory Medicine, Istituto Nazionale Tumori, IRCCS Foundation.
authors.forename: Daniele
authors.initials: D
authors.lastname: Morelli
authors.affiliation: Medical Oncology Department, Istituto Nazionale Tumori, IRCCS Foundation.
authors.forename: Elisa
authors.initials: E
authors.lastname: Sottotetti
authors.affiliation: Medical Oncology Department, Istituto Nazionale Tumori, IRCCS Foundation.
authors.forename: Antonia
authors.initials: A
authors.lastname: Martinetti
authors.affiliation: Department of Preventive and Predictive Medicine, Unit of Hereditary Digestive Tract Tumors, Istituto Nazionale Tumori, IRCCS Foundation.
authors.forename: Stefano
authors.initials: S
authors.lastname: Signoroni
authors.affiliation: Department of Clinical Sciences and Community Health, University of Milan, and.
authors.forename: Carlotta
authors.initials: C
authors.lastname: Galeone
authors.affiliation: Department of Surgery, Istituto Nazionale Tumori, IRCCS Foundation, Milan, Italy.
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Gallino
mesh_terms: D057868:Anastomotic Leak / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000473:pathology*; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D011183:Postoperative Complications / Q000097:blood*; D011237:Predictive Value of Tests; D012372:ROC Curve; D055293:Receptors, Urokinase Plasminogen Activator / Q000097:blood*; D012189:Retrospective Studies; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D055293:Receptors, Urokinase Plasminogen Activator