title: Cerebral oxygen saturation during the first 72h after birth in infants diagnosed prenatally with congenital heart disease.
abstract: Evidence suggests that hypoxic-ischemic brain injury in infants with congenital heart disease already occurs during early life. The aim of our study was, therefore, to assess the course of regional cerebral oxygen saturation (rcSO2) and fractional tissue oxygen extraction (FTOE) during the first 72h after birth in infants with prenatally diagnosed duct-dependent congenital heart disease. In addition, we identified clinical parameters that were associated with rcSO2.
  
  
  
  We included 56 infants with duct-dependent congenital heart disease. We measured arterial oxygen saturation (SpO2) and rcSO2during the first 72h after birth. Simultaneously, we calculated FTOE.
  
  
  
  We observed median rcSO2values of approximately 60%, a decreasing FTOE from 0.34 on day 1 to 0.28 on day 3 and stable preductal SpO2values around 90%. Several clinical variables were associated with rcSO2. In a multiple linear regression model only type of CHD and preductal SpO2were significant predictors of rcSO2during the first three days after birth. Infants with a duct-dependent pulmonary circulation had up to 12% lower rcSO2values than infants with a duct-dependent systemic circulation.
  
  
  
  We demonstrated that, during the first three days after birth, cerebral oxygen saturation is low in infants with duct-dependent congenital heart disease. Furthermore, this study provides preoperative reference values of rcSO2and FTOE in infants with duct-dependent CHD.
authors.affiliation: University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Division of Neonatology, Groningen, The Netherlands. Electronic address: m.j.mebius01@umcg.nl.
authors.forename: Mirthe J
authors.initials: MJ
authors.lastname: Mebius
authors.affiliation: University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Division of Neonatology, Groningen, The Netherlands.
authors.forename: Michelle E
authors.initials: ME
authors.lastname: van der Laan
authors.affiliation: University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Division of Neonatology, Groningen, The Netherlands.
authors.forename: Elise A
authors.initials: EA
authors.lastname: Verhagen
authors.affiliation: University of Groningen, University Medical Center Groningen, Center for Congenital Heart Diseases, Pediatric Cardiology, Beatrix Children's Hospital, Groningen, The Netherlands.
authors.forename: Marcus Tr
authors.initials: MT
authors.lastname: Roofthooft
authors.affiliation: University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Division of Neonatology, Groningen, The Netherlands.
authors.forename: Arend F
authors.initials: AF
authors.lastname: Bos
authors.affiliation: University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Division of Neonatology, Groningen, The Netherlands.
authors.forename: Elisabeth Mw
authors.initials: EM
authors.lastname: Kooi
mesh_terms: D001921:Brain / Q000378:metabolism*; D002545:Brain Ischemia / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism*; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010101:Oxygen Consumption; D011296:Prenatal Diagnosis
keywords: Congenital heart disease; Near-infrared spectroscopy; Neonatal intensive care unit; Newborn infants; Pulmonary circulation; Systemic circulation