title: Effect of Ca+2ion on the release of diltiazem hydrochloride from matrix tablets of carboxymethyl xanthan gum graft polyacrylamide.
abstract: The effect of Ca2+ion cross-linker on acryalamide grafted carboxymethyl xanthan gum (CMXG-g-PAAm) on the drug release was investigated. Previously, CMXG was synthesized from XG and further grafted to CMXG-g-PAAm to retard the drug release. Once the CaCl2solution is added to CMXG-g-PAAm, Ca2+considerably affected the drug release mechanism mainly by diffusion and erosion. In order to validate the grafted polymer, tablets were prepared using wet granulation and dry granulation methods It has been noticed that the tablets prepared by wet granulation successfully controls the release of the drug over an extended period of time. Moreover, the release profile was aligned to Korsmeyer-Peppas equation and exhibited the drug transport mechanism via diffusion and erosion.
authors.affiliation: Rungta College of Pharmaceutical Sciences and Research, Bhilai 490024, Chhattisgarh, India.
authors.forename: Hemant R
authors.initials: HR
authors.lastname: Badwaik
authors.affiliation: Rungta College of Pharmaceutical Sciences and Research, Bhilai 490024, Chhattisgarh, India.
authors.forename: Kalyani
authors.initials: K
authors.lastname: Sakure
authors.affiliation: Rungta College of Pharmaceutical Sciences and Research, Bhilai 490024, Chhattisgarh, India.
authors.forename: Kartik T
authors.initials: KT
authors.lastname: Nakhate
authors.affiliation: Shri Rawatpura Sarkar Institute of Pharmacy, Kumhari 490042, Chhattisgarh, India.
authors.forename: Pranita
authors.initials: P
authors.lastname: Kashayap
authors.affiliation: Shri Rawatpura Sarkar Institute of Pharmacy, Kumhari 490042, Chhattisgarh, India.
authors.forename: Hemant
authors.initials: H
authors.lastname: Dhongade
authors.affiliation: Rungta College of Pharmaceutical Sciences and Research, Bhilai 490024, Chhattisgarh, India. Electronic address: itsmeamitalex@gmail.com.
authors.forename: Amit
authors.initials: A
authors.lastname: Alexander
authors.affiliation: Rungta College of Pharmaceutical Sciences and Research, Bhilai 490024, Chhattisgarh, India.
authors.lastname: Ajazuddin
authors.affiliation: Rungta College of Pharmaceutical Sciences and Research, Bhilai 490024, Chhattisgarh, India.
authors.forename: Dulal Krishna
authors.initials: DK
authors.lastname: Tripathi
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000645:Ammonium Sulfate / Q000737:chemistry; D000818:Animals; D002122:Calcium Chloride / Q000737:chemistry*; D002413:Cations, Divalent; D003432:Cross-Linking Reagents / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000138:chemical synthesis* / Q000494:pharmacology; D004058:Diffusion; D004110:Diltiazem / Q000737:chemistry*; D004339:Drug Compounding; D065546:Drug Liberation; D005260:Female; D007700:Kinetics; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013607:Tablets; D023382:Toxicity Tests, Acute; D000099166:Polyacrylamides
chemical_list: D000180:Acrylic Resins; D000645:Ammonium Sulfate; D002122:Calcium Chloride; D002413:Cations, Divalent; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D004110:Diltiazem; D011135:Polysaccharides, Bacterial; D013607:Tablets; D000099166:Polyacrylamides; C031276:ammonium peroxydisulfate; C002563:xanthan gum
keywords: Carboxymethyl xanthan gum-graft-polyacrylamide; Cross-linker; Wet granulation