title: Culture and drug sensitivity testing among patients with pulmonary tuberculosis in Mexico: national data for 2009-2013.
abstract: This study documented the number and results of mycobacterial culture and drug sensitivity testing (CDST) in Mexico from 2009-2013 and assessed whether states with a higher risk of multidrug-resistant tuberculosis (MDR-TB) performed more CDST and had more cultures showing MDR-TB. Data for this longitudinal, descriptive, operational research study came from the electronic records of 31 state public health laboratories in Mexico. The total number of CDSTs was 6 470, increasing from 2 143 in the first 2 years to 4 327 in the latter 3 years. There was a significant increase in the proportion of cultures showing sensitivity to all drugs, from 53.1% to 60.9% in 2011-2013 (P < 0.001) and a significant decrease in the proportion showing MDR-TB, from 28.2% in 2009 to 19.8% in 2013 (P < 0.001). Cases of extensively drug resistant tuberculosis were < 1% per year. In the 12 states with higher risk for MDR-TB, significantly more CDSTs (2 382 test) were done in 2011-2013 than in the other 19 states (1 945 tests). Also, for each year the proportion of cultures showing MDR-TB was significantly higher in high risk MDR-TB states than in lower risk ones (P < 0.001). During the 5-year study period, CDST was scaled up in Mexico, particularly in high-risk MDR-TB states where a higher proportion of cultures showed MDR-TB. Scale up and wider coverage of CDST should continue.
authors.forename: Ivonne
authors.initials: I
authors.lastname: Orejel
authors.forename: Martin
authors.initials: M
authors.lastname: Castellanos
authors.forename: Diana
authors.initials: D
authors.lastname: Marín
authors.forename: Alberto
authors.initials: A
authors.lastname: Mendoza
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Harries
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use; D006801:Humans; D008800:Mexico; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents