title: Non-Canonical EZH2 Transcriptionally Activates RelB in Triple Negative Breast Cancer.
abstract: Enhancer of zeste homology 2 (EZH2) is the methyltransferase component of the polycomb repressive complex (PRC2) which represses gene transcription via histone H3 trimethylation at lysine 23 (H3K27me3). EZH2 activity has been linked with oncogenesis where it is thought to block expression of certain tumor suppressors. Relative to a role in cancer, EZH2 functions to promote self-renewal and has been shown to be important for the tumor-initiating cell (TIC) phenotype in breast cancer. Recently a non-canonical role for EZH2 has been identified where it promotes transcriptional activation of certain genes. Here we show that EZH2, through a methyltransferase-independent mechanism, promotes the transcriptional activation of the non-canonical NF-κB subunit RelB to drive self-renewal and the TIC phenotype of triple-negative breast cancer cells.
authors.affiliation: Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America.
authors.forename: Cortney L
authors.initials: CL
authors.lastname: Lawrence
authors.affiliation: Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America.
authors.forename: Albert S
authors.initials: AS
authors.lastname: Baldwin
mesh_terms: D045744:Cell Line, Tumor; D000071221:Enhancer of Zeste Homolog 2 Protein / Q000378:metabolism*; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase / Q000378:metabolism; D006801:Humans; D051841:Transcription Factor RelB / Q000235:genetics*; D015533:Transcriptional Activation; D064726:Triple Negative Breast Neoplasms / Q000473:pathology*
chemical_list: C497593:RELB protein, human; D051841:Transcription Factor RelB; D000076983:Histone Methyltransferases; D000071221:Enhancer of Zeste Homolog 2 Protein; D011495:Histone-Lysine N-Methyltransferase