title: TiO2-containing and ZnO-containing borosilicate glass-a novel thin glass with exceptional antibiofilm performances to prevent microfouling.
abstract: Biofilm formation, also known as microfouling, on indwelling medical devices such as catheters or prosthetic joints causes difficult to treat and recurrent infections. It is also the initial step for biocorrosion of surfaces in aquatic environment. An efficient prevention of microfouling is preferable but the development of antibiofilm surfaces is enormously challenging. Therefore, soda-lime, aluminosilicate, and three borosilicate glasses with different TiO2and ZnO compositions were investigated on their feasibility to prevent biofilm formation by standardized in vitro biofilm assays using different pathogenic bacteria. Furthermore, the biocompatibility of these glasses was evaluated using eukaryotic cell lines end erythrocytes. Only two borosilicate glasses, containing TiO2and ZnO, showed an increased antibiofilm performance inhibiting biofilm adhesion and formation. The biofilm thickness and area were significantly reduced by over 90 % and characterized by diffuse structures. All tested glass types showed neither cytotoxicity nor hemotoxicity. Therefore, the antibiofilm borosilicate-thin glasses are qualified for surface coatings where biofilms are not desirable such as on medical devices.
authors.affiliation: Center for Infectious Diseases and Infection Control, Jena University Hospital, Jena, 07747, Germany. mareike.klinger@med.uni-jena.de.|Center for Sepsis Control and Care, Jena University Hospital, Jena, 07747, Germany. mareike.klinger@med.uni-jena.de.
authors.forename: Mareike
authors.initials: M
authors.lastname: Klinger-Strobel
authors.affiliation: Center for Infectious Diseases and Infection Control, Jena University Hospital, Jena, 07747, Germany.|Center for Sepsis Control and Care, Jena University Hospital, Jena, 07747, Germany.
authors.forename: Oliwia
authors.initials: O
authors.lastname: Makarewicz
authors.affiliation: Center for Infectious Diseases and Infection Control, Jena University Hospital, Jena, 07747, Germany.|Center for Sepsis Control and Care, Jena University Hospital, Jena, 07747, Germany.
authors.forename: Mathias W
authors.initials: MW
authors.lastname: Pletz
authors.affiliation: Center for Sepsis Control and Care, Jena University Hospital, Jena, 07747, Germany.|Department of Internal Medicine IV, Jena University Hospital, Jena, 07747, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Stallmach
authors.affiliation: Center for Sepsis Control and Care, Jena University Hospital, Jena, 07747, Germany.|Department of Internal Medicine IV, Jena University Hospital, Jena, 07747, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Lautenschläger
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry; D001422:Bacterial Adhesion / Q000187:drug effects; D001672:Biocompatible Materials; D018441:Biofilms; D001895:Boron / Q000737:chemistry*; D002460:Cell Line; D004912:Erythrocytes / Q000166:cytology; D005898:Glass / Q000737:chemistry*; D006801:Humans; D051379:Mice; D017640:Silicates / Q000737:chemistry*; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*; D015034:Zinc Oxide / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D017640:Silicates; C009495:titanium dioxide; D014025:Titanium; D001895:Boron; D015034:Zinc Oxide