title: Loss of Conventional Melanocytic Markers in Malignant Melanoma and Lymph Node Metastasis; an Uncommon but Dangerous Pitfall.
abstract: Although malignant melanomas exhibit a wide range of immunophenotypes, concurrent loss of all 3 conventional melanocytic markers (S-100, Melan-A, and HMB-45) is relatively rare. We report a case of primary malignant melanoma with lymph node metastasis, both exhibiting loss of immunoreactivity for conventional melanocytic markers, while aberrantly expressing epithelial antigenicity (pancytokeratin, CAM 5.2).
authors.affiliation: *Department of Anatomic Pathology, University of Washington Medical Center, Seattle, WA; and †Department of Anatomic Pathology, VA Puget Sound Health Care System, Seattle, WA.
authors.forename: Oliver
authors.initials: O
authors.lastname: Chang
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Argenyi
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D006801:Humans; D008207:Lymphatic Metastasis / Q000175:diagnosis*; D058965:MART-1 Antigen / Q000096:biosynthesis; D008297:Male; D008545:Melanoma / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D058950:Melanoma-Specific Antigens / Q000096:biosynthesis; D008875:Middle Aged; D009418:S100 Proteins / Q000096:biosynthesis; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D058951:gp100 Melanoma Antigen; D000096142:Cutaneous Malignant Melanoma
chemical_list: D014408:Biomarkers, Tumor; D058965:MART-1 Antigen; C548667:MLANA protein, human; D058950:Melanoma-Specific Antigens; C548637:PMEL protein, human; D009418:S100 Proteins; D058951:gp100 Melanoma Antigen