title: The Photostabilizing Effect of Grape Seed Extract on Three Common Sunscreen Absorbers.
abstract: The photostabilizing ability of grape seed extract on three common sunscreen absorbers, 2-ethylhexyl-p-methoxycinnamate (EHMC), benzophenone-3 (BP3) and tert-butylmethoxy dibenzoylmethane (BMDBM), was investigated. Samples were exposed to simulated solar radiation and monitored by spectrophotometric and chromatographic methods. The chemical composition of the grape seed extract was determined by GC-MS and HPLC-MS, and the major secondary metabolites were found to be epicatechin and catechin. Exposure of the extract to UV radiation increased the UV absorption capacity of the extract. All sunscreens showed an improved photostability in the extract. The inherent photo-instability of BMDBM when exposed to UV radiation was almost eliminated in the presence of grape seed extract. A mixture of all three sunscreens in the extract showed very high photostability and a red shift covering the entire UVB and UVA regions, thereby improving the broad-spectrum protection. The incorporation of grape seed extract in sunscreen and other cosmetic formulations for topical application boosts photoprotection by stabilizing the UV filters and enhancing broad-spectrum coverage. This in turn helps in reducing the amounts of absorbers and other additives incorporated in a sunscreen product and consequently lowers the risk of an unprecedented buildup of photoproducts whose toxicities are currently unknown.
authors.affiliation: School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa.
authors.forename: Bice S
authors.initials: BS
authors.lastname: Martincigh
authors.affiliation: School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa.
authors.forename: Moses A
authors.identifier: 0000-0002-8649-0578
authors.initials: MA
authors.lastname: Ollengo
mesh_terms: D004355:Drug Stability; D008401:Gas Chromatography-Mass Spectrometry; D056604:Grape Seed Extract / Q000737:chemistry / Q000494:pharmacology*; D011835:Radiation Protection; D013473:Sunscreening Agents / Q000737:chemistry*
chemical_list: D056604:Grape Seed Extract; D013473:Sunscreening Agents