title: Natural Killer T-Cell Lymphoma of the Orbit: An Evidence-Based Approach.
abstract: Natural killer T-cell lymphoma (NKTCL) is a rare and aggressive condition with a high mortality rate. It is most commonly seen in the nasal sinuses, generally affecting the orbit by direct extension. Primary orbital NKTCL is even more rare, with only a few published cases with occasional secondary nasal involvement. This malignancy can present as a "masquerade syndrome," delaying proper diagnosis and treatment. Biopsy is required for diagnosis, which shows specific histopathological characteristics. Radiation and chemotherapy are the mainstay of treatment. Newer chemotherapies show improved prognosis.
authors.affiliation: a Ophthalmic Plastic and Reconstructive Surgery Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School , Boston , MA , USA.
authors.forename: Juan C
authors.initials: JC
authors.lastname: Jiménez-Pérez
authors.affiliation: a Ophthalmic Plastic and Reconstructive Surgery Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School , Boston , MA , USA.
authors.forename: Michael K
authors.initials: MK
authors.lastname: Yoon
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001706:Biopsy; D003131:Combined Modality Therapy; D003952:Diagnostic Imaging; D019317:Evidence-Based Medicine; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis / Q000628:therapy; D054391:Lymphoma, Extranodal NK-T-Cell / Q000175:diagnosis / Q000628:therapy; D009918:Orbital Neoplasms / Q000175:diagnosis / Q000628:therapy; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis / Q000628:therapy; D011878:Radiotherapy
chemical_list: D000970:Antineoplastic Agents
keywords: Extranodal natural killer T-cell; natural killer cell; orbital lymphoma