title: No associations exist between mean platelet volume or platelet distribution width and thyroid function in Chinese.
abstract: Mean platelet volume (MPV) and platelet distribution width (PDW) are morphometric indices of size distribution and variability of platelet. We aimed to explore the associations between MPV or PDW and thyroid function in a large Chinese cohort.This was a cross-sectional study with a recruitment of 13,622 self-reported healthy Chinese (8424 males, 5198 females). Clinical data of the participants comprised of anthropometric measurements, hepatic function, renal function, serum levels of lipid, glucose, C-reactive protein, erythrocyte sedimentation rate, platelet, MPV, PDW, and thyroid hormones. Database was sorted by sex, and the associations between MPV or PDW and thyroid function were analyzed by quartiles of MPV or PDW. Levels of MPV and PDW were compared in different thyroid function subgroups by 1-way analysis of variance and independent sample's t test. Receiver-operating characteristic (ROC) curve was adopted to determine diagnostic values of MPV and PDW for thyroid dysfunction. Crude and adjusted odds ratios of MPV and PDW for thyroid dysfunction with 95% confidence intervals were analyzed by binary logistic regression models.MPV, PDW, and thyroid stimulation hormone were significantly higher in females than in males. Females showed significantly higher incidence of hypothyroidism and hyperthyroidism than males. However, there were no significant differences of MPV and PDW among different thyroid function subgroups in both sexes, and no obvious correlations were revealed between MPV or PDW and thyroid function. From ROC analysis, we demonstrated no diagnostic values of MPV and PDW for thyroid dysfunction. From binary logistic regression models, no risks of different MPV and PDW quartiles were identified for thyroid dysfunction in both sexes.We could not show any association between MPV or PDW and thyroid function. Prospective studies with better defined risk groups should be performed in the future for further verification and validation.
authors.affiliation: Department of Endocrinology and Metabolism Department of Nuclear Medicine Department of Health Management, Tianjin Medical University General Hospital, Tianjin, P.R. China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Ren
authors.forename: Zhaowei
authors.initials: Z
authors.lastname: Meng
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.forename: Mei
authors.initials: M
authors.lastname: Zhu
authors.forename: Qing
authors.initials: Q
authors.lastname: He
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Kun
authors.initials: K
authors.lastname: Song
authors.forename: Qiyu
authors.initials: Q
authors.lastname: Jia
authors.forename: Qiang
authors.initials: Q
authors.lastname: Jia
authors.forename: Xue
authors.initials: X
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Tan
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.forename: Renfei
authors.initials: R
authors.lastname: Wang
authors.forename: Na
authors.initials: N
authors.lastname: Liu
authors.forename: Tianpeng
authors.initials: T
authors.lastname: Hu
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D010976:Platelet Count; D012372:ROC Curve; D012737:Sex Factors; D013959:Thyroid Diseases / Q000097:blood* / Q000208:ethnology*; D013963:Thyroid Hormones / Q000097:blood
chemical_list: D013963:Thyroid Hormones