title: Reactive oxygen species and bacterial biofilms in diabetic wound healing.
abstract: Chronic wounds are a common and debilitating complication for the diabetic population. It is challenging to study the development of chronic wounds in human patients; by the time it is clear that a wound is chronic, the early phases of wound healing have passed and can no longer be studied. Because of this limitation, mouse models have been employed to better understand the early phases of chronic wound formation. In the past few years, a series of reports have highlighted the importance of reactive oxygen species and bacterial biofilms in the development of chronic wounds in diabetics. We review these recent findings and discuss mouse models that are being utilized to enhance our understanding of these potentially important contributors to chronic wound formation in diabetic patients.
authors.affiliation: Department of Vascular Surgery, David Geffen School of Medicine, Los Angeles, California.|Department of Podiatric Medicine and Surgery, Department of Veteran Affairs of Greater Los Angeles Healthcare System, Los Angeles, California.
authors.forename: Aksone
authors.initials: A
authors.lastname: Nouvong
authors.affiliation: Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, California; and.|Department of Biological Chemistry, David Geffen School of Medicine, Los Angeles, California.
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Ambrus
authors.affiliation: Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, California; and.|Department of Biological Chemistry, David Geffen School of Medicine, Los Angeles, California.
authors.forename: Ellen R
authors.initials: ER
authors.lastname: Zhang
authors.affiliation: Department of Podiatric Medicine and Surgery, Department of Veteran Affairs of Greater Los Angeles Healthcare System, Los Angeles, California.
authors.forename: Lucas
authors.initials: L
authors.lastname: Hultman
authors.affiliation: Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, California; and hcoller@ucla.edu.|Department of Biological Chemistry, David Geffen School of Medicine, Los Angeles, California.
authors.forename: Hilary A
authors.initials: HA
authors.lastname: Coller
mesh_terms: D000818:Animals; D018441:Biofilms / Q000254:growth & development*; D003920:Diabetes Mellitus / Q000378:metabolism* / Q000382:microbiology*; D006801:Humans; D017382:Reactive Oxygen Species / Q000378:metabolism*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D017382:Reactive Oxygen Species
keywords: biofilm; diabetes; reactive oxygen species; wounds