title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) role in hematopoiesis and in hematologic diseases: A critical review.
abstract: Dioxin exposure and its effect on hematopoiesis and cancer have been largely investigated in both human and non-human settings. Here we systematically reviewed literature to address the question of what we know about TCDD biology and exposure. Most effects are due to TCDD interaction with a receptor of xenobiotics called AHR, which is ubiquitously represented and also works on hematopoietic myeloid and lymphoid stem cells, inducing proliferation and stem cell release from bone marrow to peripheral circulation. Epidemiologic studies on TCDD exposure demonstrated an association with onco-hematologic diseases, particularly with non Hodgkin lymphomas and multiple myeloma, and non hematologic cancers, such as sarcomas, although these relationships are affected by multiple confounding factors.
authors.affiliation: UO Onco-Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, via F. Sforza 35, 20100, Milano, Italy. Electronic address: n.fracchiolla@policlinico.mi.it.
authors.forename: Nicola Stefano
authors.initials: NS
authors.lastname: Fracchiolla
authors.affiliation: UO Onco-Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, via F. Sforza 35, 20100, Milano, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Annaloro
authors.affiliation: UO Onco-Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, via F. Sforza 35, 20100, Milano, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Guidotti
authors.affiliation: UO Onco-Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, via F. Sforza 35, 20100, Milano, Italy.
authors.forename: Bruno
authors.initials: B
authors.lastname: Fattizzo
authors.affiliation: UO Onco-Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, via F. Sforza 35, 20100, Milano, Italy; UO Onco-Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, via F Sforza 35, 20100, Milano, Italy.
authors.forename: Agostino
authors.initials: A
authors.lastname: Cortelezzi
mesh_terms: D000818:Animals; D004785:Environmental Pollutants / Q000633:toxicity*; D006402:Hematologic Diseases / Q000139:chemically induced* / Q000453:epidemiology; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D051379:Mice; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*
chemical_list: D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins
keywords: 2,3,7,8-Tetrachlorodibenzo-p-dioxin; Aryl hydrocarbon receptor; Hematopoiesis; non Hodgkin lymphoma