title: Epidemiology of critical states during pregnancy after assisted reproductive technologies.
abstract: OBJECTIVE
  The aim of this research was to have a thorough study of predictors of critical states during pregnancy after assisted reproductive technologies.
  
  
  METHODS
  A retrospective study of 303 patients with "near-miss," out of which 37 are pregnancy cases after ART (the main group) and 265 are spontaneous pregnancy cases (the control group).
  
  
  RESULTS
  Pregnancy after ART constituted 12.3% of all critical states. In the main group (10.8%), severe ovarian hyperstimulation prevailed over all possible reasons for critical states within the period of up to 22 weeks of gestation, whereas bleeding predominated in the control group (57.1%). When pregnancy terms exceeded 22 weeks, the leading reason for "near-miss" in the main group was preeclampsia (59.5%) with underlying thrombophilia (29.7%) and gestation pancreatic diabetes (32.4%); bleeding was the main factor in the control group (36.6%).
  
  
  CONCLUSIONS
  Women after assisted reproductive technologies constitute a high-risk group for critical obstetric states not only in the nearest time period but also long after ART.
authors.affiliation: a FSBI "Ural Research Institute of Maternity and Childhood Protection" Public Health Ministry of Russian Federation , Yekaterinburg , Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Bashmakova
authors.affiliation: a FSBI "Ural Research Institute of Maternity and Childhood Protection" Public Health Ministry of Russian Federation , Yekaterinburg , Russia.
authors.forename: N B
authors.initials: NB
authors.lastname: Davydenko
authors.affiliation: a FSBI "Ural Research Institute of Maternity and Childhood Protection" Public Health Ministry of Russian Federation , Yekaterinburg , Russia.
authors.forename: G B
authors.initials: GB
authors.lastname: Malgina
authors.affiliation: a FSBI "Ural Research Institute of Maternity and Childhood Protection" Public Health Ministry of Russian Federation , Yekaterinburg , Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Putilova
mesh_terms: D000328:Adult; D016640:Diabetes, Gestational / Q000453:epidemiology; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D027724:Reproductive Techniques, Assisted / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D019851:Thrombophilia / Q000453:epidemiology
keywords: Assisted reproductive technologies; critical obstetric states; infertility; near-miss; preeclampsia; thrombophilia