title: Clinical manifestations of colorectal cancer patients from a large multicenter study in Colombia.
abstract: Colorectal cancer (CRC) is a major public health problem, and its incidence is rising in developing countries. However, studies characterizing CRC clinicopathological features in cases from developing countries are still lacking. The goal of this study was to evaluate clinicopathological and demographic features in one of the largest CRC studies in Latin America.The study involved over 1525 CRC cases recruited in a multicenter study in Colombia between 2005 and 2014 as part of ongoing genetic and epidemiological studies. We gathered clinicopathological data such as age at diagnosis, sex, body mass index, tobacco and alcohol consumption, family history of cancer, and tumor features including location, histological type, and stage. Statistical analyses were performed to test the association between age of onset, sex, and clinical manifestations.The average age at CRC diagnosis was 57.4 years, with 26.5% of cases having early-onset CRC (diagnosed by age 50 years). Most cases were women (53.2%; P = 0.009), 49.2% were overweight or obese, 49.1% were regular alcohol drinkers, 52% were smokers/former smokers, and 12.2% reported relatives with cancer. Most tumors in the study were located in the rectum (42.7%), were adenocarcinomas (91.5%), and had advanced stage (T3-T4, 79.8%). Comparisons by sex found that male cases were more likely to be obese (36.5% vs 31.1%; P = 0.001), less likely to have a family history of cancer (9.7% vs 15.3%; P = 0.016), and more likely to have advanced-stage tumors (83.9% vs 76.1%; P = 0.036). Comparisons by age of onset found that early-onset cases were more likely to be women (59.3% vs 51.0%; P = 0.005) and report a family history of cancer (17.4% vs 10.2%; P = 0.001).To our knowledge, our study is the largest report of clinicopathological characterization of Hispanic CRC cases, and we suggest that further studies are needed to understand CRC etiology in diverse Hispanic populations.
authors.affiliation: Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, CA Grupo de Investigación Citogenética, Filogenia y Evolución de Poblaciones, Facultades de Ciencias y de Ciencias de Salud, Universidad del Tolima, Ibagué, Colombia Instituto Nacional de Cancerología, Bogotá, DC, Colombia Hospital Pablo Tobón Uribe, Medellín, Colombia Hospital Federico Lleras Acosta, Ibagué, Colombia Clinica Las Américas, Medellín, Colombia Hospital Hernando Moncaleano Perdomo, Neiva, Colombia Universidad Surcolombiana, Neiva, Colombia Patologos Asociados Tolima, Ibagué, Colombia Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK Fundación de Genética y Genómica, Medellín, Colombia.
authors.forename: Mabel
authors.initials: M
authors.lastname: Bohorquez
authors.forename: Ruta
authors.initials: R
authors.lastname: Sahasrabudhe
authors.forename: Angel
authors.initials: A
authors.lastname: Criollo
authors.forename: María Carolina
authors.initials: MC
authors.lastname: Sanabria-Salas
authors.forename: Alejandro
authors.initials: A
authors.lastname: Vélez
authors.forename: Jorge Mario
authors.initials: JM
authors.lastname: Castro
authors.forename: Juan Ricardo
authors.initials: JR
authors.lastname: Marquez
authors.forename: Gilbert
authors.initials: G
authors.lastname: Mateus
authors.forename: Fernando
authors.initials: F
authors.lastname: Bolaños
authors.forename: Cesar
authors.initials: C
authors.lastname: Panqueva
authors.forename: Jose Ignacio
authors.initials: JI
authors.lastname: Restrepo
authors.forename: Juan Dario
authors.initials: JD
authors.lastname: Puerta
authors.forename: Raul
authors.initials: R
authors.lastname: Murillo
authors.forename: María Mercedes
authors.initials: MM
authors.lastname: Bravo
authors.forename: Gustavo
authors.initials: G
authors.lastname: Hernández
authors.forename: Angela
authors.initials: A
authors.lastname: Rios
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Prieto
authors.forename: Ian
authors.initials: I
authors.lastname: Tomlinson
authors.forename: Magdalena
authors.initials: M
authors.lastname: Echeverry
authors.forename: Luis G
authors.initials: LG
authors.lastname: Carvajal-Carmona
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D000428:Alcohol Drinking / Q000453:epidemiology; D015992:Body Mass Index; D003105:Colombia / Q000453:epidemiology; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012737:Sex Factors; D012907:Smoking / Q000453:epidemiology; D055815:Young Adult