title: No Overt Deficits in Aged Tau-Deficient C57Bl/6.Mapttm1(EGFP)Kit GFP Knockin Mice.
abstract: Several mouse lines with knockout of the tau-encoding MAPT gene have been reported in the past; they received recent attention due to reports that tau reduction prevented Aβ-induced deficits in mouse models of Alzheimer's disease. However, the effects of long-term depletion of tau in vivo remained controversial. Here, we used the tau-deficient GFP knockin line Mapttm1(EGFP)kit on a pure C57Bl/6 background and subjected a large cohort of males and females to a range of motor, memory and behavior tests and imaging analysis, at the advanced age of over 16 months. Neither heterozygous nor homozygous Mapttm1(EGFP)kit mice presented with deficits or abnormalities compared to wild-type littermates. Differences to reports using other tau knockout models may be due to different genetic backgrounds, respective gene targeting strategies or other confounding factors, such as nutrition. To this end, we report no functional or morphological deficits upon tau reduction or depletion in aged mice.
authors.affiliation: Dementia Research Unit, Department of Anatomy, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
authors.forename: Annika
authors.initials: A
authors.lastname: van Hummel
authors.affiliation: Dementia Research Unit, Department of Anatomy, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
authors.forename: Mian
authors.initials: M
authors.lastname: Bi
authors.affiliation: Dementia Research Unit, Department of Anatomy, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
authors.forename: Stefania
authors.initials: S
authors.lastname: Ippati
authors.affiliation: Dementia Research Unit, Department of Anatomy, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
authors.forename: Julia
authors.initials: J
authors.lastname: van der Hoven
authors.affiliation: Dementia Research Unit, Department of Anatomy, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
authors.forename: Alexander
authors.initials: A
authors.lastname: Volkerling
authors.affiliation: Dementia Research Unit, Department of Anatomy, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
authors.forename: Wei S
authors.initials: WS
authors.lastname: Lee
authors.affiliation: Dementia Research Unit, Department of Anatomy, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
authors.forename: Daniel C S
authors.initials: DC
authors.lastname: Tan
authors.affiliation: Biological Resources Imaging Laboratory, Mark Wainright Analytical Centre, University of New South Wales, Sydney, NSW, Australia.
authors.forename: Andre
authors.initials: A
authors.lastname: Bongers
authors.affiliation: Dementia Research Unit, Department of Anatomy, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
authors.forename: Arne
authors.initials: A
authors.lastname: Ittner
authors.affiliation: Motor Neuron Disease Unit, Department of Anatomy, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
authors.forename: Yazi D
authors.initials: YD
authors.lastname: Ke
authors.affiliation: Dementia Research Unit, Department of Anatomy, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.|Neuroscience Research Australia, Sydney, NSW, Australia.
authors.forename: Lars M
authors.initials: LM
authors.lastname: Ittner
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000503:physiopathology; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D004195:Disease Models, Animal; D005260:Female; D055879:Gene Knock-In Techniques; D055786:Gene Knockout Techniques; D049452:Green Fluorescent Proteins / Q000235:genetics; D008124:Locomotion; D008297:Male; D018782:Maze Learning; D008568:Memory; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D016875:tau Proteins / Q000235:genetics*
chemical_list: C558298:Mapt protein, mouse; D016875:tau Proteins; D049452:Green Fluorescent Proteins