title: Thalidomide in Refractory Tuberculomas and Pseudoabscesses.
abstract: Paradoxical immune reconstitution inflammatory syndrome is a well-described entity even in immunocompetent children, principally in association with Mycobacterium tuberculosis infections. Central nervous system involvement is a potential life-threatening form, sometimes refractory to standard treatment. We report the case of an HIV-negative refugee teenager, who presented with brain tuberculomas and pseudoabscesses responsive only to thalidomide.
authors.affiliation: From the *Department of Pediatrics, †Division of Infectious Diseases, Department of Pediatrics, and ‡Division of Allergy-Immunology, Department of Medicine, CHU de Quebec, Quebec, Quebec, Canada.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Viel-Thériault
authors.forename: Roseline
authors.initials: R
authors.lastname: Thibeault
authors.forename: Francois D
authors.initials: FD
authors.lastname: Boucher
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Drolet
mesh_terms: D000293:Adolescent; D000995:Antitubercular Agents / Q000627:therapeutic use*; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome; D008279:Magnetic Resonance Imaging; D013792:Thalidomide / Q000627:therapeutic use*; D014375:Tuberculoma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000995:Antitubercular Agents; D013792:Thalidomide