title: Daily Ingestion of Aloe Vera Gel Powder Containing Aloe Sterols Prevents Skin Photoaging in OVX Hairless Mice.
abstract: Estrogen deficiencies associated with menopause accelerate spontaneous skin aging and stimulate the ultraviolet (UV) irradiation-induced photoaging of skin. However, food compositions with the potential to ameliorate the UV irradiation-induced acceleration of skin aging with menopause have not yet been investigated in detail. In the present study, we examined the ability of plant sterols derived from Aloe vera gel to prevent the UV irradiation-induced acceleration of skin aging in ovariectomized mice. Skin transepidermal water loss (TEWL) was significantly higher in the ovariectomy group than in the sham operation group following UVB irradiation, whereas skin elasticity was significantly lower. Ultraviolet B (UVB) irradiation induced greater reductions in skin hyaluronic acid levels and more severe collagen fiber damage in the derims in the ovariectomy group than in the sham group. The intake of AVGP significantly ameliorated this acceleration in skin aging by reducing the expression of matrix metalloproteinases (MMPs) and increasing that of epidermal growth factor (EGF) and hyaluronan synthase (HAS) in the skin. These results indicate that AVGP supplementation prevents skin damage induced by UVB irradiation and ovariectomy in part by inhibiting damage to the extracellular matrix.
authors.affiliation: Functional Food Research Dept, Food Science & Technology Inst, Morinaga Milk Industry Co., Ltd, Higashihara 5-1-83, Zama, Kanagawa, 252-8583, Japan.
authors.forename: Ruiqing
authors.initials: R
authors.lastname: Yao
authors.affiliation: Functional Food Research Dept, Food Science & Technology Inst, Morinaga Milk Industry Co., Ltd, Higashihara 5-1-83, Zama, Kanagawa, 252-8583, Japan.
authors.forename: Miyuki
authors.initials: M
authors.lastname: Tanaka
authors.affiliation: Functional Food Research Dept, Food Science & Technology Inst, Morinaga Milk Industry Co., Ltd, Higashihara 5-1-83, Zama, Kanagawa, 252-8583, Japan.
authors.forename: Eriko
authors.initials: E
authors.lastname: Misawa
authors.affiliation: Functional Food Research Dept, Food Science & Technology Inst, Morinaga Milk Industry Co., Ltd, Higashihara 5-1-83, Zama, Kanagawa, 252-8583, Japan.
authors.forename: Marie
authors.initials: M
authors.lastname: Saito
authors.affiliation: Functional Food Research Dept, Food Science & Technology Inst, Morinaga Milk Industry Co., Ltd, Higashihara 5-1-83, Zama, Kanagawa, 252-8583, Japan.
authors.forename: Kazumi
authors.initials: K
authors.lastname: Nabeshima
authors.affiliation: Functional Food Research Dept, Food Science & Technology Inst, Morinaga Milk Industry Co., Ltd, Higashihara 5-1-83, Zama, Kanagawa, 252-8583, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Yamauchi
authors.affiliation: Functional Food Research Dept, Food Science & Technology Inst, Morinaga Milk Industry Co., Ltd, Higashihara 5-1-83, Zama, Kanagawa, 252-8583, Japan.
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Abe
authors.affiliation: Dept. of Dermatology, Wakayama Medical Univ, 811-1, Kimiidera, Wakayama, 641-0012, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Yamamoto
authors.affiliation: Dept. of Dermatology, Wakayama Medical Univ, 811-1, Kimiidera, Wakayama, 641-0012, Japan.
authors.forename: Fukumi
authors.initials: F
authors.lastname: Furukawa
keywords: Aloe vera gel; EGF; MMPs; estrogen deficiency; photoaging