title: MicroRNA-105 targets SOX9 and inhibits human glioma cell progression.
abstract: Growing evidence indicates that microRNA (miRNA) play vital roles in glioma progression by directly regulating multiple targets. Here, we found that miR-105 expression was significantly decreased and inversely correlated with SOX9 mRNA expression in glioma tissues. SOX9 was identified as a direct target of miR-105. miR-105 up-regulation repressed the expression of SOX9, TCF4, c-MYC, cyclin D1, and AXIN2 and suppressed glioma cell progression. Restoration of SOX9 or TCF4 abolished the effect of miR-105 on glioma cell progression. SOX9 down-regulation had similar effects as miR-105 up-regulation on glioma progression. Moreover, TCF4 restoration rescued the effect of SOX9 down-regulation on glioma progression. Altogether, these findings suggested that miR-105 functions as a potential tumor suppressor by regulating the SOX9/TCF4 axis in glioma.
authors.affiliation: Department of Neurosurgery, Institute of Neurosurgery, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
authors.forename: Xiyao
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, Institute of Neurosurgery, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
authors.forename: Huiqing
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Institute of Neurosurgery, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
authors.forename: Zhiyun
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Department of Neurosurgery, Institute of Neurosurgery, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
authors.forename: Yongyi
authors.initials: Y
authors.lastname: Ye
authors.affiliation: Department of Neurosurgery, Institute of Neurosurgery, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
authors.forename: Hengxu
authors.initials: H
authors.lastname: Mao
authors.affiliation: Department of Neurosurgery, Institute of Neurosurgery, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
authors.forename: Shizhong
authors.initials: S
authors.lastname: Zhang
mesh_terms: D017209:Apoptosis / Q000235:genetics; D001483:Base Sequence; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000235:genetics; D001932:Brain Neoplasms / Q000235:genetics / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000235:genetics; D015536:Down-Regulation; D005910:Glioma / Q000235:genetics / Q000473:pathology*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009361:Neoplasm Invasiveness / Q000235:genetics; D055758:SOX9 Transcription Factor / Q000235:genetics*; D000073940:Transcription Factor 4; D014157:Transcription Factors / Q000235:genetics; D015854:Up-Regulation
chemical_list: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; C588223:MIRN105 microRNA, human; D035683:MicroRNAs; D055758:SOX9 Transcription Factor; C527932:SOX9 protein, human; C532096:TCF4 protein, human; D000073940:Transcription Factor 4; D014157:Transcription Factors
keywords: SOX9; TCF4; apoptosis; glioma; miR-105