title: [Depression and heart failure - a twofold hazard? : Diagnosis, prognostic relevance and treatment of an underestimated comorbidity].
abstract: Heart failure and depression are widespread diseases and of particular clinical and economic relevance. Compared with the general population depression is up to 5‑times more common in patients with heart failure, with adverse effects on morbidity, mortality, quality of life and treatment costs. Depressive symptoms overlap with those of heart failure which renders diagnosis difficult. Simple screening tools, e. g. the two-item patient health questionnaire, help to recognize depression in the clinical routine. To date, there is no evidence that antidepressant pharmacotherapy improves mood and clinical outcomes in patients with heart failure and comorbid depression and antidepressant pharmacotherapy remains to be decided on a case by case basis; however, physical training, cognitive behavioral therapy and multidisciplinary comprehensive disease management improved symptoms and/or prognosis in a limited number of randomized studies.
authors.affiliation: Medizinische Klinik und Poliklinik I, Deutsches Zentrum für Herzinsuffizienz (DZHI) Universitätsklinikum und Universität Würzburg, Straubmühlweg 2a, Haus A9, 97078, Würzburg, Deutschland.
authors.forename: J
authors.initials: J
authors.lastname: Wallenborn
authors.affiliation: Medizinische Klinik und Poliklinik I, Deutsches Zentrum für Herzinsuffizienz (DZHI) Universitätsklinikum und Universität Würzburg, Straubmühlweg 2a, Haus A9, 97078, Würzburg, Deutschland. Angermann_C@ukw.de.
authors.forename: C E
authors.initials: CE
authors.lastname: Angermann
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use; D015984:Causality; D015928:Cognitive Behavioral Therapy / Q000379:methods / Q000706:statistics & numerical data; D015897:Comorbidity; D003863:Depression / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D003937:Diagnosis, Differential; D003951:Diagnostic Errors / Q000517:prevention & control*; D005858:Germany / Q000453:epidemiology; D006333:Heart Failure / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D006801:Humans; D015995:Prevalence; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents
keywords: Antidepressant drugs; Cardiovascular diseases; Comorbidity; Depressive symptoms; Multimodal treatment