title: Genetic Polymorphisms in SOD (rs2070424, rs7880) and CAT (rs7943316, rs1001179) Enzymes Are Associated with Increased Body Fat Percentage and Visceral Fat in an Obese Population from Central Mexico.
abstract: Oxidative disturbance is an important factor involved in the etiology of comorbidities associated with obesity. Genetic polymorphisms such as SOD1 -251A>G, SOD2 47 C>T, CAT -21A>T and CAT -262 C>T have been described to alter the activity of antioxidant enzymes. The aim of the present work was to analyze the association of the mentioned SNPs with obesity and their relationship with anthropometric and clinical variables in this group.
  
  
  
  The study included 416 Mexican women (208 normal weight, NW and 208 subjects with obesity, OB). Dietary intake, anthropometric, biochemical and clinical features were evaluated and then analyzed in function of the genotypes.
  
  
  
  The mutated carriers (GA+GG) of SOD -251 were significantly higher in the OB group (0.24) compared to the NW group (0.08). The other SNPs showed no differences compared with control group. When comparing carrier mutated subjects with obesity vs. wild-type obese participants with the SNPs SOD1 -251, SOD2 47 and CAT -262, the carriers showed a significantly (p <0.05) higher value in body fat percentage. Also, carriers of SOD2 47 and CAT-262 showed significantly higher values (p = 0.002) and (p = 0.01), respectively, when visceral fat was compared between groups. Systolic blood pressure was significantly higher (p = 0.02) in carriers of mutated CAT-21.
  
  
  
  SOD1 -251A>G is associated with obesity independent of the presence of diabetes or dyslipidemia. Mutated obese carries of SOD1 -251, SOD2 47 and CAT -262 are associated with a higher distribution of fat in comparison with obese wild-type carriers.
authors.affiliation: Departamento de Salud, Universidad Iberoamericana, Mexico City, México. Electronic address: cesar.hernandez@ibero.mx.
authors.forename: César
authors.initials: C
authors.lastname: Hernández-Guerrero
authors.affiliation: Departamento de Salud, Universidad Iberoamericana, Mexico City, México.
authors.forename: Paulina
authors.initials: P
authors.lastname: Hernández-Chávez
authors.affiliation: Departamento de Salud, Universidad Iberoamericana, Mexico City, México.
authors.forename: Inés
authors.initials: I
authors.lastname: Romo-Palafox
authors.affiliation: Departamento de Salud, Universidad Iberoamericana, Mexico City, México.
authors.forename: Grecia
authors.initials: G
authors.lastname: Blanco-Melo
authors.affiliation: Departamento de Salud, Universidad Iberoamericana, Mexico City, México.
authors.forename: Alicia
authors.initials: A
authors.lastname: Parra-Carriedo
authors.affiliation: Dirección de Posgrado, Universidad Iberoamericana, Mexico City, México.
authors.forename: Ana
authors.initials: A
authors.lastname: Pérez-Lizaur
mesh_terms: D000273:Adipose Tissue / Q000503:physiopathology*; D000328:Adult; D000886:Anthropometry; D001794:Blood Pressure; D002374:Catalase / Q000097:blood / Q000235:genetics*; D003920:Diabetes Mellitus / Q000097:blood / Q000503:physiopathology; D005260:Female; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D050152:Intra-Abdominal Fat / Q000503:physiopathology; D008800:Mexico; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000235:genetics* / Q000503:physiopathology; D020641:Polymorphism, Single Nucleotide; D013482:Superoxide Dismutase / Q000097:blood / Q000235:genetics*; D000072105:Superoxide Dismutase-1 / Q000097:blood / Q000235:genetics*; D000099156:Superoxide Dismutase 2
chemical_list: D002374:Catalase; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1; D000099156:Superoxide Dismutase 2; C000606290:SOD1 protein, human
keywords: Catalase; Genetic polymorphisms; Obesity; Oxidative disturbance; Superoxide dismutase