title: Cobalt-Catalyzed Reductive Cross-Coupling Between Styryl and Benzyl Halides.
abstract: A simple and efficient protocol for the direct reductive cross-coupling between alkenyl and benzyl halides using a Co/Mn system has been developed. This reaction proceeds smoothly in the presence of [CoBr2(PPh3)2] as the catalyst, with NaI as an additive in acetonitrile with a broad scope of functionalized alkenyl and benzyl halides. Different functional groups are tolerated on both coupling partners, thus, significantly extending the general scope of transition-metal-catalyzed benzylation of alkenyl halides. Moderate to excellent yields were also obtained. From a mechanistic point of view, a radical chain mechanism was proposed. This reaction is stereospecific and some studies suggest the retention of the double-bond configuration.
authors.affiliation: LCM, CNRS, Ecole Polytechnique, Université Paris-Saclay, 91128, Palaiseau, France.
authors.forename: Yingxiao
authors.initials: Y
authors.lastname: Cai
authors.affiliation: Department of Chemistry, Ludwig-Maximilians-Universität, Butenandtstr. 5-13, 81377, Munich, Germany.
authors.forename: Andreas D
authors.initials: AD
authors.lastname: Benischke
authors.affiliation: Department of Chemistry, Ludwig-Maximilians-Universität, Butenandtstr. 5-13, 81377, Munich, Germany.
authors.forename: Paul
authors.initials: P
authors.lastname: Knochel
authors.affiliation: LCM, CNRS, Ecole Polytechnique, Université Paris-Saclay, 91128, Palaiseau, France.
authors.forename: Corinne
authors.initials: C
authors.lastname: Gosmini
keywords: alkenyl; benzyl; cobalt; cross-coupling; retention of configuration