title: Cerebral Proliferative Angiopathy (CPA): Imaging Findings and Response to Therapy.
abstract: We report the case of a 55-year-old woman with cerebral proliferative angiopathy (CPA). Her medical history included brain surgery for small vascular lesions and suspicion of cerebral malignancy. C methionine PET (C-METH PET) demonstrated a diffusely increased uptake on the right hemisphere. Contrast-enhanced MRI documented a massive lesion with a diffuse "nidus" appearance, involving the right cerebral hemisphere (sparing the inferior frontal gyrus and the anterior frontal lobe), the brainstem, and the middle cerebellar peduncle. Pathology confirmed the diagnosis of CPA and, after radiation treatment, the patient presented with clinical and radiological response.
authors.affiliation: From the *Nuclear Medicine, Humanitas Clinical and Research Hospital, Rozzano (MI); †Department of Health Sciences, Centre of Molecular and Cellular Imaging, University of Milan, Milan; ‡Neurosurgery, Humanitas Clinical and Research Hospital, Rozzano (MI); §Radiotherapy and Radiosurgery, Humanitas Clinical and Research Hospital, Rozzano (MI); and ∥Humanitas University, Rozzano (MI), Italy.
authors.forename: Egesta
authors.initials: E
authors.lastname: Lopci
authors.forename: Laura
authors.initials: L
authors.lastname: Olivari
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Bello
authors.forename: Pierina
authors.initials: P
authors.lastname: Navarria
authors.forename: Arturo
authors.initials: A
authors.lastname: Chiti
mesh_terms: D001165:Arteriovenous Malformations / Q000000981:diagnostic imaging* / Q000628:therapy; D002250:Carbon Radioisotopes; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008715:Methionine; D008875:Middle Aged; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals
chemical_list: D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D008715:Methionine