title: A Historical and Evolutionary Perspective on Circulating Nucleic Acids and Extracellular Vesicles: Circulating Nucleic Acids as Homeostatic Genetic Entities.
abstract: The quantitative and qualitative differences of circulating nucleic acids (cirNAs) between healthy and diseased individuals have motivated researchers to utilize these differences in the diagnosis and prognosis of various pathologies. The position maintained here is that reviewing the rather neglected early work associated with cirNAs and extracellular vesicles (EVs) is required to fully describe the nature of cirNAs. This review consists of an empirically up-to-date schematic summary of the major events that developed and integrated the concepts of heredity, genetic information and cirNAs. This reveals a clear pattern implicating cirNA as a homeostatic entity or messenger of genetic information. The schematic summary paints a picture of how cirNAs may serve as homeostatic genetic entities that promote synchrony of both adaptation and damage in tissues and organs depending on the source of the message.
authors.affiliation: Centre for Human Metabolomics, Biochemistry Division, North-West University, Potchefstroom, 2520, South Africa. aucampj@telkomsa.net.
authors.forename: Janine
authors.initials: J
authors.lastname: Aucamp
authors.affiliation: Centre for Human Metabolomics, Biochemistry Division, North-West University, Potchefstroom, 2520, South Africa.
authors.forename: Abel Jacobus
authors.initials: AJ
authors.lastname: Bronkhorst
authors.affiliation: Centre for Human Metabolomics, Biochemistry Division, North-West University, Potchefstroom, 2520, South Africa.
authors.forename: Piet J
authors.initials: PJ
authors.lastname: Pretorius
mesh_terms: D005075:Biological Evolution; D022083:Cytoplasmic Structures / Q000378:metabolism; D004247:DNA / Q000097:blood / Q000235:genetics / Q000378:metabolism; D055354:Exosomes / Q000235:genetics*; D000067128:Extracellular Vesicles / Q000235:genetics*; D006706:Homeostasis; D006801:Humans; D008070:Lipopolysaccharides / Q000378:metabolism; D009696:Nucleic Acids / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D012313:RNA / Q000097:blood / Q000235:genetics / Q000378:metabolism
chemical_list: D008070:Lipopolysaccharides; D009696:Nucleic Acids; D012313:RNA; D004247:DNA
keywords: Bystander effect; Circulating nucleic acids; Extracellular vesicles; Genetic homeostasis; Genometastasis; Metabolic DNA