title: Hypothesis Driven versus Hypothesis-free: Filling the Gaps in CoQ Biosynthesis.
abstract: Two independent investigations based on the power of yeast genetics, but using radically different discovery-driven approaches, have solved a long-pursued goal: the understanding of the early steps in CoQ biosynthesis, which may help diagnose CoQ deficiencies of unknown origin (Payet et al., 2016; Stefely et al., 2016).
authors.affiliation: Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain; Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, 50009 Zaragoza, Spain. Electronic address: jaenriquez@cnic.es.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Enríquez
authors.affiliation: Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain.
authors.forename: Fátima
authors.initials: F
authors.lastname: Sánchez-Cabo
authors.affiliation: Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Vázquez
mesh_terms: D001259:Ataxia; D028361:Mitochondrial Diseases; D018908:Muscle Weakness; D014451:Ubiquinone
chemical_list: D014451:Ubiquinone