title: Neutrophil mechanotransduction: A GEF to sense fluid shear stress.
abstract: Forces deriving from blood flow shear modulate vascular adherence and transendothelial migration of leukocytes into inflamed tissues, but the mechanisms by which shear is sensed are unclear. In this issue, Fine et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603109) identify the guanosine nucleotide exchange factor GEF-H1 as critical for shear stress-induced transendothelial neutrophil migration.
authors.affiliation: Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065 niethamp@mskcc.org.
authors.forename: Philipp
authors.initials: P
authors.lastname: Niethammer
mesh_terms: D000818:Animals; D020013:Calcium Signaling; D020662:Guanine Nucleotide Exchange Factors / Q000378:metabolism*; D007249:Inflammation / Q000473:pathology; D007424:Intracellular Fluid / Q000378:metabolism*; D040542:Mechanotransduction, Cellular; D051379:Mice; D008870:Microtubules / Q000378:metabolism; D009504:Neutrophils / Q000166:cytology* / Q000378:metabolism*; D013314:Stress, Mechanical
chemical_list: D020662:Guanine Nucleotide Exchange Factors