title: Gene expression analysis reveals the dysregulation of immune and metabolic pathways in Alzheimer's disease.
abstract: In recent years, several pathway analyses of genome-wide association studies reported the involvement of metabolic and immune pathways in Alzheimer's disease (AD). Until now, the exact mechanisms of these pathways in AD are still unclear. Here, we conducted a pathway analysis of a whole genome AD case-control expression dataset (n=41, 25 AD cases and 16 controls) from the human temporal cortex tissue. Using the differently expressed AD genes, we identified significant KEGG pathways related to metabolism and immune processes. Using the up- and down- regulated AD gene list, we further found up-regulated AD gene were significantly enriched in immune and metabolic pathways. We further compare the immune and metabolic KEGG pathways from the expression dataset with those from previous GWAS datasets, and found that most of these pathways are shared in both GWAS and expression datasets.
authors.affiliation: Department of Neurology, The First Affiliated Hospital, Harbin Medical University, Harbin, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital, Harbin Medical University, Harbin, China.
authors.forename: Chuncheng
authors.initials: C
authors.lastname: Xie
authors.affiliation: Department of Internal Hematology, The First Affiliated Hospital, Harbin Medical University, Harbin, China.
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Neurology, The First Affiliated Hospital, Harbin Medical University, Harbin, China.
authors.forename: Zhiyan
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Neurology, The First Affiliated Hospital, Harbin Medical University, Harbin, China.
authors.forename: Panpan
authors.initials: P
authors.lastname: Xu
authors.affiliation: Department of Neurology, The First Affiliated Hospital, Harbin Medical University, Harbin, China.
authors.forename: Lifen
authors.initials: L
authors.lastname: Yao
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D016022:Case-Control Studies; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D006801:Humans; D053858:Metabolic Networks and Pathways / Q000235:genetics
keywords: Alzheimer’s disease; Pathology Section; expression data; pathway analysis