title: Young patient with arterial thrombosis and skin changes as the onset manifestations: POEMS syndrome.
abstract: POEMS syndrome is a rare multi-systemic disease characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes. Arterial thrombosis is a distinctively unusual feature in patients with POEMS syndrome. We report a 33-year-old man with intermittent amaurosis of left eye and skin changes as the onset manifestations, who was finally confirmed as having POEMS syndrome. Most notably, this was a young man without high risk factors of arterial thrombosis and no monoclonal protein was detected until the repeated measurement later. This case evokes the need to consider the diagnosis of POEMS syndrome for young patients with symptoms of arterial thrombosis but no high risk factors of thrombosis.
authors.affiliation: Department of Endocrinology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Han
authors.affiliation: Department of Endocrinology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Zheng
authors.affiliation: Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Zeng-Ai
authors.initials: ZA
authors.lastname: Chen
authors.affiliation: Department of Endocrinology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Yao-Min
authors.initials: YM
authors.lastname: Hu
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D016878:POEMS Syndrome / Q000097:blood / Q000473:pathology / Q000503:physiopathology*; D012867:Skin / Q000473:pathology*; D013927:Thrombosis / Q000209:etiology* / Q000473:pathology
keywords: POEMS syndrome; atypical feature; monoclonal protein; thrombosis; young patient