title: Helicobacter pylori Infection Aggravates Diet-induced Insulin Resistance in Association With Gut Microbiota of Mice.
abstract: Emerging evidence suggests that Helicobacter pylori infection is associated with insulin resistance (IR) yet the underlying mechanisms are still obscure. The vital role of gut microbiota in triggering IR has been increasingly reported, however, no study has explored the correlation of gut microbiota and H. pylori-associated IR. Using H. pylori-infected mice model fed different diet structures, we demonstrated that H. pylori infection significantly aggravated high-fat diet (HFD)-induced metabolic disorders at the early stage, the extent of which was close to the effect of long-term HFD. Interestingly, we observed dynamic alterations in gut microbiota that were consistent with the changes in the metabolic phenotype induced by H. pylori and HFD. There may be an interaction among H. pylori, diet and gut microbiota, which dysregulates the host metabolic homeostasis, and treatment of H. pylori may be beneficial to the patients with impaired glucose tolerance in addition to diet control.
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
authors.forename: Cong
authors.initials: C
authors.lastname: He
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Cheng
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Xie
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: Zhongming
authors.initials: Z
authors.lastname: Ge
authors.affiliation: Institute of Basic Medical Sciences, Nanchang University, Nanchang, Jiangxi 330006, China; Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA.
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Luo
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China. Electronic address: lunonghua@ncu.edu.cn.
authors.forename: Nonghua
authors.initials: N
authors.lastname: Lu
mesh_terms: D000818:Animals; D015415:Biomarkers; D016207:Cytokines / Q000097:blood; D059305:Diet, High-Fat / Q000009:adverse effects; D004195:Disease Models, Animal; D018450:Disease Progression; D000069196:Gastrointestinal Microbiome; D005947:Glucose / Q000378:metabolism; D016481:Helicobacter Infections / Q000378:metabolism* / Q000382:microbiology*; D016480:Helicobacter pylori; D006706:Homeostasis; D018836:Inflammation Mediators / Q000097:blood; D007328:Insulin / Q000097:blood / Q000378:metabolism; D007333:Insulin Resistance; D008297:Male; D054892:Metagenome; D056186:Metagenomics / Q000379:methods; D051379:Mice; D056128:Obesity, Abdominal / Q000209:etiology / Q000378:metabolism
chemical_list: D015415:Biomarkers; D016207:Cytokines; D018836:Inflammation Mediators; D007328:Insulin; D005947:Glucose
keywords: Gut microbiota; Helicobacter pylori; High-fat diet; Insulin resistance