title: Function of Cryopreserved Mesenchymal Stromal Cells With and Without Interferon-γ Prelicensing is Context Dependent.
abstract: Tailoring MSCs to fit the disease. Fresh, cryopreserved and, prelicensed cryopreserved MSC are all being explored to treat numerous diseases, but all are not suitable to treat all conditions. injury. "*" denotes preferred therapeutic strategy when both fresh MSC and cryo-MSC have shown utility in treating the disease but one is more efficacious or logistically suitable.
  
  
  
  CLI, critical limb ischemia; GvHD. graft versus host disease; I/R, ischemia reperfusion (I/R); OI, osteogenesis imperfecta.
authors.affiliation: Department of Biomedical Engineering, University of Iowa, Iowa City, IA.|Fraternal Order of Eagles Diabetes Research Center, Pappajohn Biomedical Institute, University of Iowa, Iowa City, IA.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Burand
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA.
authors.forename: Oliver W
authors.initials: OW
authors.lastname: Gramlich
authors.affiliation: Department of Biomedical Engineering, University of Iowa, Iowa City, IA.|Fraternal Order of Eagles Diabetes Research Center, Pappajohn Biomedical Institute, University of Iowa, Iowa City, IA.
authors.forename: Alex J
authors.initials: AJ
authors.lastname: Brown
authors.affiliation: Fraternal Order of Eagles Diabetes Research Center, Pappajohn Biomedical Institute, University of Iowa, Iowa City, IA.
authors.forename: James A
authors.identifier: 0000-0003-3959-6158
authors.initials: JA
authors.lastname: Ankrum
mesh_terms: D000818:Animals; D015925:Cryopreservation; D006801:Humans; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000378:metabolism; D007371:Interferon-gamma / Q000494:pharmacology*; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000187:drug effects; D008810:Mice, Inbred C57BL; D015427:Reperfusion Injury / Q000473:pathology
chemical_list: D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D007371:Interferon-gamma
keywords: Cell transplantation; Immunosuppression; Indoleamine 2,3 dioxygenase; Mesenchymal stem cells; Retina