title: Ameliorative Potential of Prepartal Trace Mineral and Vitamin Supplementation on Parturition-Induced Redox Balance and Myeloperoxidase Activity of Periparturient Sahiwal Cows.
abstract: Twelve apparently healthy multiparous parturient Sahiwal cows were allocated into two groups having six cows in each one. Six cows were supplemented with antioxidant mixture (mixture containing Cu, Mn, Cr, Zn, and vitamins A and D3) daily from 21 days before parturition till the day relative to calving. Whereas, remaining non-supplemented six cows were kept as the control group. Blood samples were obtained five times: at enrolment (21 days pre-partum), and again at days 0, +7, +14, and +21 relative to calving. In the non-supplemented control group, serum total antioxidant capacity (TAC) was significantly lower at days 0, +7, and +14 as compared to their own day -21 values. Likewise, significantly lower myeloperoxidase (MPO) activities were also exhibited by these cows at days 0 and +7. Conversely, serum malondialdehyde (MDA) and protein carbonyl (PC) levels were significantly higher in these cows at days 0, +7, +14, and +21. However, significant alterations in TAC content among the studied sampling days were not recorded in antioxidants supplemented group. Moreover, TAC content and MPO activities of supplemented group were significantly higher at days 0, +7, and +14 when compared with that of the non-supplemented control group. However, MDA and PC contents of supplemented group were significantly lower at days 0, +7, +14, and +21 as compared to that of the non-supplemented control group. In conclusion, periparturient Sahiwal cows experience substantial oxidative and immunological dents which can be potentially ameliorated by prepartal trace mineral and vitamin supplementation.
authors.affiliation: Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, U.P, 281 001, India.
authors.forename: Brajesh K
authors.initials: BK
authors.lastname: Yadav
authors.affiliation: Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, U.P, 281 001, India. pshankervet@gmail.com.
authors.forename: Shanker K
authors.initials: SK
authors.lastname: Singh
authors.affiliation: Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, U.P, 281 001, India.
authors.forename: Udayraj P
authors.initials: UP
authors.lastname: Nakade
authors.affiliation: Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, U.P, 281 001, India.
authors.forename: Vivek K
authors.initials: VK
authors.lastname: Singh
authors.affiliation: Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, U.P, 281 001, India.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Sharma
authors.affiliation: Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, U.P, 281 001, India.
authors.forename: Mukesh
authors.initials: M
authors.lastname: Srivastava
authors.affiliation: Departmet of Physiology, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, U.P, 281 001, India.
authors.forename: Brijesh
authors.initials: B
authors.lastname: Yadav
authors.affiliation: Department of Livestock Production and Management, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, U.P, 281 001, India.
authors.forename: Yajuvendra
authors.initials: Y
authors.lastname: Singh
authors.affiliation: Department of Livestock Production and Management, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, U.P, 281 001, India.
authors.forename: Rajneesh
authors.initials: R
authors.lastname: Sirohi
authors.affiliation: Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, U.P, 281 001, India.
authors.forename: Satish K
authors.initials: SK
authors.lastname: Garg
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002417:Cattle; D019587:Dietary Supplements; D008903:Minerals / Q000008:administration & dosage / Q000097:blood*; D010084:Oxidation-Reduction; D009195:Peroxidase / Q000378:metabolism*; D014131:Trace Elements / Q000008:administration & dosage / Q000097:blood*; D014815:Vitamins / Q000008:administration & dosage / Q000097:blood*
chemical_list: D000975:Antioxidants; D008903:Minerals; D014131:Trace Elements; D014815:Vitamins; D009195:Peroxidase
keywords: Chromium; Copper; Lipid peroxidation; Manganese; Protein carbonyls; Total antioxidant capacity; Zinc