title: Default mode network activity and neuropsychological profile in male children and adolescents with attention deficit hyperactivity disorder and conduct disorder.
abstract: It is known that patients with Attention Deficit and Hyperactivity disorder (ADHD) and Conduct disorder (CD) commonly shows greater symptom severity than those with ADHD alone and worse outcomes. This study researches whether Default mode network (DMN) is altered in adolescents with ADHD + CD, relative to ADHD alone and controls or not. Ten medication-naïve boys with ADHD + CD, ten medication-naïve boys with ADHD and 10-age-matched typically developing (TD) controls underwent functional magnetic resonance imaging (fMRI) scans in the resting state and neuropsychological tasks such as the Wisconsin Card Sorting Test (WCST), Stroop Test TBAG Form (STP), Auditory Verbal learning Test (AVLT), Visual Auditory Digit Span B (VADS B) were applied to all the subjects included. fMRI scans can be used only nine patients in each groups. The findings revealed group differences between cingulate cortex and primary mortor cortex; cingulate cortex and somatosensory association cortex; angular gyrus (AG) and dorsal posterior cingulate cortex, in these networks increased activity was observed in participants with ADHD + CD compared with the ADHD. We found that lower resting state (rs)-activity was observed between left AG and dorsal posterior cingulate cortex, whereas higher rs-activity connectivity were detected between right AG and somatosensory association cortex in ADHD relative to the ones with ADHD + CD. In neuropsyhcological tasks, ADHD + CD group showed poor performance in WISC-R, WCST, Stroop, AVLT tasks compared to TDs. The ADHD + CD group displayed rs-functional abnormalities in DMN. Our results suggest that abnormalities in the intrinsic activity of resting state networks may contribute to the etiology of CD and poor prognosis of ADHD + CD.
authors.affiliation: Department of Child and Adolescent Psychiatry, Kayseri Research and Training Hospital, Emel-Mehmet Tarman Child Hospital, Erkilet, Kayseri, Turkey. mervecikili@yahoo.com.
authors.forename: Merve Cikili
authors.initials: MC
authors.lastname: Uytun
authors.affiliation: Department of Child and Adolescent Psychiatry, Erciyes University, Faculty of Medicine, Kayseri, Turkey.
authors.forename: Emel
authors.initials: E
authors.lastname: Karakaya
authors.affiliation: Department of Child and Adolescent Psychiatry, Surp Birgic Armenian Hospital, Istanbul, Turkey.
authors.forename: Didem Behice
authors.initials: DB
authors.lastname: Oztop
authors.affiliation: Faculty of Engineering, Biomedical Engineering, Erciyes University, Kayseri, Turkey.
authors.forename: Serife
authors.initials: S
authors.lastname: Gengec
authors.affiliation: Biomedical Imaging Research Center, Erciyes University, Kayseri, Turkey.
authors.forename: Kazım
authors.initials: K
authors.lastname: Gumus
authors.affiliation: Department of Child and Adolescent Psychiatry, Erciyes University, Faculty of Medicine, Kayseri, Turkey.
authors.forename: Sevgi
authors.initials: S
authors.lastname: Ozmen
authors.affiliation: Faculty of Medicine, Radiology, Erciyes University, Kayseri, Turkey.
authors.forename: Selim
authors.initials: S
authors.lastname: Doğanay
authors.affiliation: Faculty of Engineering, Biomedical Engineering, Erciyes University, Kayseri, Turkey.
authors.forename: Semra
authors.initials: S
authors.lastname: Icer
authors.affiliation: Department of Child and Adolescent Psychiatry, Erciyes University, Faculty of Medicine, Kayseri, Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Demirci
authors.affiliation: Faculty of Medicine, Department of Psychiatry, Erciyes University, Kayseri, Turkey.
authors.forename: Saliha Demirel
authors.initials: SD
authors.lastname: Ozsoy
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001931:Brain Mapping; D002648:Child; D019955:Conduct Disorder / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000503:physiopathology; D009483:Neuropsychological Tests; D012146:Rest
keywords: ADHD; Conduct disorder; Default mode network; Resting state; fMRI