title: Rh-Catalyzed, Regioselective, C-H Bond Functionalization: Access to Quinoline-Branched Amines and Dimers.
abstract: Rh-catalyzed, chelation-induced, C-5 regioselective C-H functionalization of 8-amidoquinolines with a range of N-Boc aminals is reported for the first time. The addition of in situ generated imines to C(sp2)-H bonds afforded branched amines in good to excellent yields. Moreover, this transformation features good functional group compatibility, broad substrate scope, and mild reaction conditions and is suitable for gram-scale synthesis. In addition, an unprecedented, chelation-induced, site-selective, remote dimerization of quinolines led to the formation of dimer frameworks in moderate yields under Rh-catalyzed conditions.
authors.affiliation: Department of Pharmaceutical Sciences, School of Pharmacy, Union University , 1050 Union University Drive, Jackson, Tennessee 38305, United States.
authors.forename: M Damoder
authors.initials: MD
authors.lastname: Reddy
authors.affiliation: Department of Chemistry, Louisiana State University , 608 Choppin Hall, Baton Rouge, Louisiana 70803, United States.
authors.forename: Frank R
authors.initials: FR
authors.lastname: Fronczek
authors.affiliation: Department of Pharmaceutical Sciences, School of Pharmacy, Union University , 1050 Union University Drive, Jackson, Tennessee 38305, United States.
authors.forename: E Blake
authors.initials: EB
authors.lastname: Watkins