title: Fasting Triglycerides and Glucose Index as a Diagnostic Test for Insulin Resistance in Young Adults.
abstract: Although the Glucose and Triglyceride levels (TyG) index is useful for identification of insulin resistance (IR) in different ethnic groups, it has not been evaluated in young adults. We undertook this study to evaluate the TyG index as a diagnostic test for IR in young adults.
  
  
  
  A total of 5,538 healthy young adults, 3,795 (68.5%) non-pregnant women and 1,743 (31.5%) men, with an average age of 19.2 ± 1.4 years, were enrolled in a population-based cross-sectional study. To estimate diagnostic characteristics of the TyG index, a randomized subsample of the target population (n = 75) was under euglycemic-hyperinsulinemic clamp test. Using the cutoff values obtained in the clamp study, the diagnostic concordance between TyG index and HOMA-IR was evaluated in the overall population. The TyG index was calculated as the Ln[fasting triglycerides (mg/dL) × fasting glucose (mg/dL)]/2.
  
  
  
  Normal weight, overweight, and obesity were identified in 3,632 (65.6%), 1,355 (24.5%), and 551 (9.9%) participants. A total of 346 (9.1%) men and 278 (15.9%) women exhibited IR. The best cutoff value of TyG index for diagnosis of IR was 4.55 (sensitivity 0.687, negative predictive value (NPV) 0.844, and negative likelihood ratio (NLR) 0.47) for women and 4.68 (sensitivity 0.673, NPV 0.900, and NLR 0.45) for men. In normal-weight individuals the diagnostic concordance between TyG index and HOMA-IR was 0.934 and 0.915, in the overweight subjects was 0.908 and 0.895 and, in the obese participants 0.916 and 0.950, for men and women, respectively.
  
  
  
  TyG index may be useful for screening IR in young adults.
authors.affiliation: Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico, and Research Group on Diabetes and Chronic Illnesses, Durango, Mexico.
authors.forename: Fernando
authors.initials: F
authors.lastname: Guerrero-Romero
authors.affiliation: Faculty of Higher Studies Iztacala, National Autonomous University of Mexico (UNAM), Mexico City, Mexico.
authors.forename: Rafael
authors.initials: R
authors.lastname: Villalobos-Molina
authors.affiliation: Faculty of Higher Studies Iztacala, National Autonomous University of Mexico (UNAM), Mexico City, Mexico.
authors.forename: J Rafael
authors.initials: JR
authors.lastname: Jiménez-Flores
authors.affiliation: Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico, and Research Group on Diabetes and Chronic Illnesses, Durango, Mexico.
authors.forename: Luis E
authors.initials: LE
authors.lastname: Simental-Mendia
authors.affiliation: Faculty of Higher Studies Iztacala, National Autonomous University of Mexico (UNAM), Mexico City, Mexico.
authors.forename: René
authors.initials: R
authors.lastname: Méndez-Cruz
authors.affiliation: Faculty of Higher Studies Iztacala, National Autonomous University of Mexico (UNAM), Mexico City, Mexico.
authors.forename: Miguel
authors.initials: M
authors.lastname: Murguía-Romero
authors.affiliation: Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico, and Research Group on Diabetes and Chronic Illnesses, Durango, Mexico. Electronic address: rodriguez.moran.martha@gmail.com.
authors.forename: Martha
authors.initials: M
authors.lastname: Rodríguez-Morán
mesh_terms: D000328:Adult; D001774:Blood Chemical Analysis / Q000379:methods*; D001786:Blood Glucose / Q000032:analysis*; D003430:Cross-Sectional Studies; D005215:Fasting; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D050177:Overweight / Q000097:blood / Q000175:diagnosis; D014280:Triglycerides / Q000097:blood*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D014280:Triglycerides
keywords: Insulin resistance; Triglycerides; Triglycerides and glucose index; Young adults