title: Cytoreductive surgery and intraperitoneal chemotherapy for peritoneal carcinomatosis of colorectal cancer: 2-year follow-up results at a single institution in Korea.
abstract: OBJECTIVE
  The purpose of this study was to examine 2-year follow-up results of cytoreductive surgery (CRS) and intraperitoneal chemotherapy (IPC) for peritoneal carcinomatosis (PC) of colorectal cancer.
  
  
  METHODS
  We performed 54 cases of CRS and IPC in 53 patients with PC of colorectal cancer from December 2011 to December 2013. We collected data prospectively and analyzed the grade of PC, morbidity and mortality, and short-term follow-up (median, 10 months; range, 2-47 months) results.
  
  
  RESULTS
  Mean peritoneal cancer index (PCI) was 15 (range, 1-35), and complete cytoreduction was possible in 35 patients (64.8%). Complications occurred in 25 patients (46.3%) and mortality occurred in 4 patients (7.4%). Excluding the 4 mortalities, 17 patients out of 49 patients (31.5%) were alive at the time of the last follow-up and the overall median survival was 10.3 months. Patients with complete cytoreduction had a median survival of 22.6 months, which was significantly longer than the median survival of 3.5 months for patients without complete cytoreduction (P < 0.001). PCI grade, CCR grade, cell type, and postoperative chemotherapy were significant prognostic factors by univariate analysis. Positive independent prognostic factors by multivariate analysis included PCI grade and postoperative chemotherapy.
  
  
  CONCLUSIONS
  CRS and IPC increased the survival of patients with low PCI and postoperative systemic chemotherapy was mandatory. However, this combined therapeutic approach showed high rate of complications and mortality. Therefore, this aggressive treatment should be performed in only selected patients by considering the general condition of the patient and the extent of PC.
authors.affiliation: Department of Surgery, Dankook University College of Medicine, Cheonan, Korea.
authors.forename: Min Hyeong
authors.initials: MH
authors.lastname: Jo
authors.affiliation: Department of Surgery, Dankook University College of Medicine, Cheonan, Korea.
authors.forename: Jung Wook
authors.initials: JW
authors.lastname: Suh
authors.affiliation: Department of Surgery, Dankook University College of Medicine, Cheonan, Korea.
authors.forename: Jeong Seok
authors.initials: JS
authors.lastname: Yun
authors.affiliation: Department of Surgery, Dankook University College of Medicine, Cheonan, Korea.
authors.forename: Hwan
authors.initials: H
authors.lastname: Namgung
authors.affiliation: Department of Surgery, Dankook University College of Medicine, Cheonan, Korea.
authors.forename: Dong-Guk
authors.initials: DG
authors.lastname: Park
keywords: Colorectal neoplasms; Cytoreductive surgery; Intraperitoneal chemotherapy; Peritoneal carcinomatosis