title: Dynamic modelling of strategies for the control of acute haemorrhagic conjunctivitis outbreaks in schools in Changsha, China (2004-2015).
abstract: Outbreaks of acute haemorrhagic conjunctivitis (AHC) - a rapidly progressing and highly contagious infection - often occur in schools during summer and autumn. We used dynamic modelling to evaluate the efficacy of interventions to control AHC outbreaks in schools. A susceptible-infected-recovered (SIR) model was built to simulate AHC outbreaks in Chinese schools, with isolation or school closure added into the model. We used outbreak data from the period 2004-2015 in our models to estimate the effective reproduction number and assess the efficacy of interventions. The median effective reproduction number (uncontrolled) of AHC outbreaks was 7·00 (range 1·77-25·87). The median effective reproduction number (controlled) of AHC outbreaks was 0·16 (range 0·00-2·28). Intervention efficacy is affected by the timing of isolation; earlier isolation is associated with a lower morbidity peak and smaller total attack rate (TAR). School closures were not effective; TARs were almost 100% and did not change even when different school closure durations were adopted. Isolation and school closure as a combined intervention strategy was used to simulate outbreak control, but the efficacy was the same as isolation alone. An isolation programme could be an effective primary intervention during AHC outbreaks in schools. However, school closure is not recommended.
authors.affiliation: Office for Disease Control and Emergency Response, Changsha Center for Disease Control and Prevention, Changsha, Hunan Province, People's Republic of China.
authors.forename: S L
authors.initials: SL
authors.lastname: Chen
authors.affiliation: Office for Disease Control and Emergency Response, Changsha Center for Disease Control and Prevention, Changsha, Hunan Province, People's Republic of China.
authors.forename: R C
authors.initials: RC
authors.lastname: Liu
authors.affiliation: Office for Disease Control and Emergency Response, Changsha Center for Disease Control and Prevention, Changsha, Hunan Province, People's Republic of China.
authors.forename: F M
authors.initials: FM
authors.lastname: Chen
authors.affiliation: Office for Disease Control and Emergency Response, Changsha Center for Disease Control and Prevention, Changsha, Hunan Province, People's Republic of China.
authors.forename: X X
authors.initials: XX
authors.lastname: Zhang
authors.affiliation: Office for Disease Control and Emergency Response, Changsha Center for Disease Control and Prevention, Changsha, Hunan Province, People's Republic of China.
authors.forename: J
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Office for Disease Control and Emergency Response, Changsha Center for Disease Control and Prevention, Changsha, Hunan Province, People's Republic of China.
authors.forename: T M
authors.initials: TM
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D050936:Basic Reproduction Number; D002648:Child; D002681:China / Q000453:epidemiology; D003232:Conjunctivitis, Acute Hemorrhagic / Q000453:epidemiology* / Q000517:prevention & control*; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D017053:Infection Control / Q000379:methods*; D008297:Male; D015233:Models, Statistical; D012574:Schools
keywords: Acute haemorrhagic conjunctivitis; dynamic model; isolation; outbreak; school closure