title: Acephate exposure during a perinatal life program to type 2 diabetes.
abstract: Acephate has been used extensively as an insecticide in agriculture. Its downstream sequelae are associated with hyperglycemia, lipid metabolism dysfunction, DNA damage, and cancer, which are rapidly growing epidemics and which lead to increased morbidity and mortality rates and soaring health-care costs. Developing interventions will require a comprehensive understanding of which excess insecticides during perinatal life can cause insulin resistance and type 2 diabetes. A Wistar rat animal model suggests that acephate exposure during pregnancy and lactation causes alterations in maternal glucose metabolism and programs the offspring to be susceptible to type 2 diabetes at adulthood. Therapeutic approaches based on preventive actions to food contaminated with insecticides during pregnancy and lactation could prevent new cases of type 2 diabetes.
authors.affiliation: Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá-5790, 87020-900 Maringá, PR, Brazil. Electronic address: tatianeribeiro2@hotmail.com.
authors.forename: Tatiane Aparecida
authors.initials: TA
authors.lastname: Ribeiro
authors.affiliation: Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá-5790, 87020-900 Maringá, PR, Brazil.
authors.forename: Kelly Valério
authors.initials: KV
authors.lastname: Prates
authors.affiliation: Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá-5790, 87020-900 Maringá, PR, Brazil.
authors.forename: Audrei
authors.initials: A
authors.lastname: Pavanello
authors.affiliation: Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá-5790, 87020-900 Maringá, PR, Brazil.
authors.forename: Ananda
authors.initials: A
authors.lastname: Malta
authors.affiliation: Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá-5790, 87020-900 Maringá, PR, Brazil.
authors.forename: Laize Peron
authors.initials: LP
authors.lastname: Tófolo
authors.affiliation: Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá-5790, 87020-900 Maringá, PR, Brazil.
authors.forename: Isabela Peixoto
authors.initials: IP
authors.lastname: Martins
authors.affiliation: Institute of Health Sciences, Federal University of Mato Grosso, 78.557-267 Sinop, MT, Brazil.
authors.forename: Júlio Cezar de
authors.initials: JC
authors.lastname: Oliveira
authors.affiliation: Laboratory of Molecular Endocrinology, Carlos Chagas Filho Biophysis Institute, Federal University of Rio de Janeiro, 21.941-902 Rio de Janeiro, RJ, Brazil.
authors.forename: Rosiane Aparecida
authors.initials: RA
authors.lastname: Miranda
authors.affiliation: Laboratory of Neuroscience and Cardiovascular Physiology, Department of Physiological Sciences, Federal University of Goiás, 74690-900 Goiânia, GO, Brazil.
authors.forename: Rodrigo Mello
authors.initials: RM
authors.lastname: Gomes
authors.affiliation: Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá-5790, 87020-900 Maringá, PR, Brazil.
authors.forename: Elaine
authors.initials: E
authors.lastname: Vieira
authors.affiliation: Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá-5790, 87020-900 Maringá, PR, Brazil.
authors.forename: Claudinéia Conationi da Silva
authors.initials: CC
authors.lastname: Franco
authors.affiliation: Molecular Signalling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 20892 Bethesda, MD, USA.
authors.forename: Luiz Felipe
authors.initials: LF
authors.lastname: Barella
authors.affiliation: Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá-5790, 87020-900 Maringá, PR, Brazil.
authors.forename: Flávio Andrade
authors.initials: FA
authors.lastname: Francisco
authors.affiliation: Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá-5790, 87020-900 Maringá, PR, Brazil.
authors.forename: Vander Silva
authors.initials: VS
authors.lastname: Alves
authors.affiliation: Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá-5790, 87020-900 Maringá, PR, Brazil.
authors.forename: Sandra da Silva
authors.initials: SD
authors.lastname: Silveira
authors.affiliation: Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá-5790, 87020-900 Maringá, PR, Brazil.
authors.forename: Veridiana Mota
authors.initials: VM
authors.lastname: Moreira
authors.affiliation: Univ. Lille, CNRS, UMR 8576, UGSF, Unité de Glycobiologie Structurale et Fonctionnelle, 59000 Lille, France.
authors.forename: Gabriel Sergio
authors.initials: GS
authors.lastname: Fabricio
authors.affiliation: Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá-5790, 87020-900 Maringá, PR, Brazil.
authors.forename: Kesia
authors.initials: K
authors.lastname: Palma-Rigo
authors.affiliation: Department of Biochemistry and Biomedical Sciences, Ob/Gyn, and Pediatrics MacMaster University-8S 4L8, Hamilton, Ontario, Canada.
authors.forename: Deborah M
authors.initials: DM
authors.lastname: Sloboda
authors.affiliation: Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá-5790, 87020-900 Maringá, PR, Brazil; UPSP-EGEAL Institut Polytechnique LaSalle de Beauvais, BP, 30313-60026 Beauvais Cedex, France.
authors.forename: Paulo Cezar de Freitas
authors.initials: PC
authors.lastname: Mathias
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D007306:Insecticides / Q000633:toxicity*; D007774:Lactation; D009946:Organothiophosphorus Compounds / Q000633:toxicity*; D063088:Phosphoramides / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar
chemical_list: D007306:Insecticides; D009946:Organothiophosphorus Compounds; D063088:Phosphoramides; C001969:acephate
keywords: Acephate; Glucose metabolism; Lactation; Lipid metabolism; Offspring; Pregnancy