title: Serious and reversible levetiracetam-induced psychiatric symptoms after resection of frontal low-grade glioma: two case histories.
abstract: Levetiracetam may induce serious behavioral disturbances, especially after surgical resection of frontal lobe low-grade glioma. Two patients, treated with levetiracetam, developed serious psychiatric complications postoperatively which completely resolved after switching to valproate. We aim to create awareness for this serious but reversible adverse effect of levetiracetam in this specific patient category.
authors.affiliation: a Department of Neurosurgery , Maastricht University Medical Center , Maastricht , the Netherlands.
authors.forename: Jeroen G V
authors.initials: JGV
authors.lastname: Habets
authors.affiliation: b Department of Psychiatry and Academic Center for Epileptology , Maastricht University Medical Center , Maastricht , the Netherlands.
authors.forename: Albert F G
authors.initials: AFG
authors.lastname: Leentjens
authors.affiliation: c Department of Neurosurgery and Academic Center for Epileptology , Maastricht University Medical Center , Maastricht , the Netherlands.
authors.forename: Olaf E M G
authors.initials: OEMG
authors.lastname: Schijns
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000150:complications / Q000601:surgery*; D003399:Craniotomy / Q000379:methods; D004827:Epilepsy / Q000188:drug therapy* / Q000209:etiology; D005625:Frontal Lobe / Q000601:surgery; D006801:Humans; D000077287:Levetiracetam; D008279:Magnetic Resonance Imaging; D008297:Male; D001523:Mental Disorders / Q000139:chemically induced*; D008875:Middle Aged; D009837:Oligodendroglioma / Q000150:complications / Q000601:surgery*; D010889:Piracetam / Q000009:adverse effects / Q000031:analogs & derivatives*; D011183:Postoperative Complications / Q000209:etiology; D014635:Valproic Acid / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D000077287:Levetiracetam; D014635:Valproic Acid; D010889:Piracetam
keywords: Low-grade glioma; behavioral changes; frontal lobe resection; levetiracetam; psychiatric symptoms; valproate