title: Nanoporous metal organic frameworks as hybrid polymer-metal composites for drug delivery and biomedical applications.
abstract: Metal organic frameworks (MOFs), porous hybrid polymer-metal composites at the nanoscale, are recent innovations in the field of chemistry; they are novel polymeric materials with diverse biomedical applications. MOFs are nanoporous materials, consisting of metal ions linked together by organic bridging ligands. The unique physical and chemical characteristics of MOFs have attracted wider attention from the scientific community, exploring their utility in the field of material science, biology, nanotechnology and drug delivery. The practical feasibility of MOFs is possible owing to their abilities for biodegradability, excellent porosity, high loading capacity, ease of surface modification, among others. In this regard, this review provides an account of various types of MOFs, their physiochemical characteristics and use in diverse disciplines of biomedical sciences - with special emphasis on drug delivery and theranostics. Moreover, this review also highlights the stability and toxicity issues of MOFs, along with their market potential for biomedical applications.
authors.affiliation: University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh, India. Electronic address: sarwar.beg@gmail.com.
authors.forename: Sarwar
authors.initials: S
authors.lastname: Beg
authors.affiliation: Department of Pharmacy, Sam Higginbottom Institute of Agriculture, Technology & Sciences, Allahabad, India.
authors.forename: Mahfoozur
authors.initials: M
authors.lastname: Rahman
authors.affiliation: UGC-Centre of Excellence in Applications of Nanomaterials, Nanoparticles and Nanocomposites (Biomedical Sciences), Panjab University, Chandigarh, India.
authors.forename: Atul
authors.initials: A
authors.lastname: Jain
authors.affiliation: University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh, India.
authors.forename: Sumant
authors.initials: S
authors.lastname: Saini
authors.affiliation: Centre de Biophysique Moléculaire (CBM)-CNRS UPR4301/University of Orléans Rue Charles Sadron, 45071 Orléans, Cedex 2, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Midoux
authors.affiliation: Centre de Biophysique Moléculaire (CBM)-CNRS UPR4301/University of Orléans Rue Charles Sadron, 45071 Orléans, Cedex 2, France.
authors.forename: Chantal
authors.initials: C
authors.lastname: Pichon
authors.affiliation: Nanomedicine Research Lab, Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard 110062, New Delhi, India.
authors.forename: Farhan Jalees
authors.initials: FJ
authors.lastname: Ahmad
authors.affiliation: Centre de Biophysique Moléculaire (CBM)-CNRS UPR4301/University of Orléans Rue Charles Sadron, 45071 Orléans, Cedex 2, France; Nanomedicine Research Lab, Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard 110062, New Delhi, India; LE STUDIUM(®) Loire Valley Institute for Advanced Studies, Centre-Val de Loire Region, 45000, France. Electronic address: sohailakhtermph@gmail.com.
authors.forename: Sohail
authors.initials: S
authors.lastname: Akhter
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000379:methods; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D000073396:Metal-Organic Frameworks / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D058608:Nanopores; D011108:Polymers / Q000737:chemistry*; D016062:Porosity
chemical_list: D004337:Drug Carriers; D000073396:Metal-Organic Frameworks; D008670:Metals; D011108:Polymers