title: Supramolecular Self-Assemblies with Nanoscale RGD Clusters Promote Cell Growth and Intracellular Drug Delivery.
abstract: In this work, we reported the generation of a novel supramolecular hydrogelator from a peptide derivative which consisted of a structural motif (e.g., Fc-FF) for supramolecular self-assembly and a functional moiety (e.g., RGD) for integrin binding. Following self-assembly in water at neutral pH, this molecule first tended to form metastable spherical aggregates, which subsequently underwent a morphological transformation to form high-aspect-ratio nanostructures over 2 h when aged at room temperature. More importantly, because of the presence of nanoscale RGD clusters on the surface of nanostructures, the self-assembled nanomaterials (e.g., nanoparticles and nanofibers) can be potentially used as a biomimetic matrix for cell culture and as a vector for cell-targeting drug delivery via multivalent RGD-integrin interactions.
authors.affiliation: State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, China.
authors.forename: Fengyang
authors.initials: F
authors.lastname: Xu
authors.affiliation: State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.affiliation: School of Biology and Basic Medical Science, Soochow University , Suzhou 215123, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Tian
authors.affiliation: State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, China.
authors.forename: Linfeng
authors.initials: L
authors.lastname: Gao
authors.affiliation: School of Biology and Basic Medical Science, Soochow University , Suzhou 215123, China.
authors.forename: Xiaju
authors.initials: X
authors.lastname: Cheng
authors.affiliation: State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Pan
authors.affiliation: School of Biology and Basic Medical Science, Soochow University , Suzhou 215123, China.
authors.forename: Ziling
authors.initials: Z
authors.lastname: Sun
authors.affiliation: State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, China.|State Key Laboratory of Molecular Engineering of Polymers, Fudan University , Shanghai 200433, China.
authors.forename: Xinming
authors.initials: X
authors.lastname: Li
mesh_terms: D016503:Drug Delivery Systems; D020100:Hydrogels; D057139:Nanofibers; D049329:Nanostructures; D010455:Peptides
chemical_list: D020100:Hydrogels; D010455:Peptides
keywords: hydrogel; multivalence; peptide; self-assembly; supramolecular