title: Effects of milk proteins on blood pressure: a meta-analysis of randomized control trials.
abstract: Certain foods or their components are widely used in the prevention and/or management of cardiovascular disease. Milk proteins have been suggested to have hypotensive properties. A number of clinical trials have been carried out to evaluate the effect of milk proteins from whole foods and supplements on blood pressure (BP). However, the effect of milk proteins on BP is not well understood. Therefore, we conducted a meta-analysis of randomized control trials to provide insight into and robust evidence concerning the overall impact of milk proteins on BP. The PubMed and Cochrane databases were searched for literature concerning the effects of milk proteins on BP up to May 2016. A random effects model was used to calculate the pooled estimates and 95% confidence intervals of effect sizes. The final analysis included seven randomized control trials involving 412 participants. Overall, milk protein interventions significantly lowered systolic BP by -3.33 mm Hg (95% confidence interval -5.62, -1.03) and diastolic BP by -1.08 mm Hg (95% confidence interval -3.38, -0.22). There was no statistical evidence of publication bias across the studies. In conclusion, this meta-analysis provides further evidence that milk proteins slightly but significantly lower both systolic and diastolic BP.
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, China.
authors.forename: Khemayanto
authors.initials: K
authors.lastname: Hidayat
authors.affiliation: Department of Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: Hong-Zhen
authors.initials: HZ
authors.lastname: Du
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, China.
authors.forename: Guo-Chong
authors.initials: GC
authors.lastname: Chen
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: Zeng-Ning
authors.initials: ZN
authors.lastname: Li
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, China.
authors.forename: Li-Qiang
authors.initials: LQ
authors.lastname: Qin
mesh_terms: D001794:Blood Pressure / Q000502:physiology*; D001795:Blood Pressure Determination; D019587:Dietary Supplements; D006801:Humans; D008894:Milk Proteins; D016032:Randomized Controlled Trials as Topic
chemical_list: D008894:Milk Proteins