title: Why Do Some Primate Malarias Relapse?
abstract: Relapse may have evolved in malaria as a mechanism to avoid suppression by more virulent species in mixed infections, thereby increasing transmission opportunities. Later evolution of long latency in Plasmodium vivax was a necessary adaptation as early hominins moved to colder areas with shorter mosquito breeding seasons. Genetic diversity was maintained through heterologous hypnozoite activation.
authors.affiliation: Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Churchill Hospital, Oxford, OX3 7LJ, United Kingdom. Electronic address: nickw@tropmedres.ac.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: White
mesh_terms: D000818:Animals; D005075:Biological Evolution; D006790:Host-Parasite Interactions; D016780:Malaria, Vivax / Q000453:epidemiology / Q000469:parasitology* / Q000473:pathology / Q000635:transmission; D010966:Plasmodium vivax / Q000502:physiology; D018419:Primate Diseases / Q000453:epidemiology / Q000469:parasitology* / Q000473:pathology / Q000635:transmission; D011323:Primates; D012008:Recurrence