title: Cannabidiol Prevents Motor and Cognitive Impairments Induced by Reserpine in Rats.
abstract: Cannabidiol (CBD) is a non-psychotomimetic compound fromCannabis sativathat presents antipsychotic, anxiolytic, anti-inflammatory, and neuroprotective effects. In Parkinson's disease patients, CBD is able to attenuate the psychotic symptoms induced by L-DOPA and to improve quality of life. Repeated administration of reserpine in rodents induces motor impairments that are accompanied by cognitive deficits, and has been applied to model both tardive dyskinesia and Parkinson's disease. The present study investigated whether CBD administration would attenuate reserpine-induced motor and cognitive impairments in rats. Male Wistar rats received four injections of CBD (0.5 or 5 mg/kg) or vehicle (days 2-5). On days 3 and 5, animals received also one injection of 1 mg/kg reserpine or vehicle. Locomotor activity, vacuous chewing movements, and catalepsy were assessed from day 1 to day 7. On days 8 and 9, we evaluated animals' performance on the plus-maze discriminative avoidance task, for learning/memory assessment. CBD (0.5 and 5 mg/kg) attenuated the increase in catalepsy behavior and in oral movements - but not the decrease in locomotion - induced by reserpine. CBD (0.5 mg/kg) also ameliorated the reserpine-induced memory deficit in the discriminative avoidance task. Our data show that CBD is able to attenuate motor and cognitive impairments induced by reserpine, suggesting the use of this compound in the pharmacotherapy of Parkinson's disease and tardive dyskinesia.
authors.affiliation: Interdisciplinary Laboratory of Clinical Neurosciences, Department of Psychiatry, Federal University of São PauloSão Paulo, Brazil; Department of Pharmacology, Federal University of São PauloSão Paulo, Brazil.
authors.forename: Fernanda F
authors.initials: FF
authors.lastname: Peres
authors.affiliation: Interdisciplinary Laboratory of Clinical Neurosciences, Department of Psychiatry, Federal University of São PauloSão Paulo, Brazil; Department of Pharmacology, Federal University of São PauloSão Paulo, Brazil.
authors.forename: Raquel
authors.initials: R
authors.lastname: Levin
authors.affiliation: Interdisciplinary Laboratory of Clinical Neurosciences, Department of Psychiatry, Federal University of São PauloSão Paulo, Brazil; Department of Pharmacology, Federal University of São PauloSão Paulo, Brazil.
authors.forename: Mayra A
authors.initials: MA
authors.lastname: Suiama
authors.affiliation: Interdisciplinary Laboratory of Clinical Neurosciences, Department of Psychiatry, Federal University of São PauloSão Paulo, Brazil; Department of Pharmacology, Federal University of São PauloSão Paulo, Brazil.
authors.forename: Mariana C
authors.initials: MC
authors.lastname: Diana
authors.affiliation: Interdisciplinary Laboratory of Clinical Neurosciences, Department of Psychiatry, Federal University of São PauloSão Paulo, Brazil; Department of Pharmacology, Federal University of São PauloSão Paulo, Brazil.
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Gouvêa
authors.affiliation: Interdisciplinary Laboratory of Clinical Neurosciences, Department of Psychiatry, Federal University of São PauloSão Paulo, Brazil; Department of Pharmacology, Federal University of São PauloSão Paulo, Brazil.
authors.forename: Valéria
authors.initials: V
authors.lastname: Almeida
authors.affiliation: Interdisciplinary Laboratory of Clinical Neurosciences, Department of Psychiatry, Federal University of São PauloSão Paulo, Brazil; Department of Pharmacology, Federal University of São PauloSão Paulo, Brazil.
authors.forename: Camila M
authors.initials: CM
authors.lastname: Santos
authors.affiliation: Department of Psychobiology, Federal University of São Paulo São Paulo, Brazil.
authors.forename: Lisandro
authors.initials: L
authors.lastname: Lungato
authors.affiliation: Department of Neuroscience and Behavior, University of São PauloRibeirão Preto, Brazil; National Institute for Translational Medicine - National Council for Scientific and Technological DevelopmentRibeirão Preto, Brazil.
authors.forename: Antônio W
authors.initials: AW
authors.lastname: Zuardi
authors.affiliation: Department of Neuroscience and Behavior, University of São PauloRibeirão Preto, Brazil; National Institute for Translational Medicine - National Council for Scientific and Technological DevelopmentRibeirão Preto, Brazil.
authors.forename: Jaime E C
authors.initials: JE
authors.lastname: Hallak
authors.affiliation: Department of Neuroscience and Behavior, University of São PauloRibeirão Preto, Brazil; National Institute for Translational Medicine - National Council for Scientific and Technological DevelopmentRibeirão Preto, Brazil.
authors.forename: José A
authors.initials: JA
authors.lastname: Crippa
authors.affiliation: Department of Psychobiology, Federal University of São Paulo São Paulo, Brazil.
authors.forename: D'Almeida
authors.initials: D
authors.lastname: Vânia
authors.affiliation: Department of Pharmacology, Federal University of São Paulo São Paulo, Brazil.
authors.forename: Regina H
authors.initials: RH
authors.lastname: Silva
authors.affiliation: Interdisciplinary Laboratory of Clinical Neurosciences, Department of Psychiatry, Federal University of São PauloSão Paulo, Brazil; Department of Pharmacology, Federal University of São PauloSão Paulo, Brazil.
authors.forename: Vanessa C
authors.initials: VC
authors.lastname: Abílio
keywords: Parkinson’s disease; cannabidiol; rat; reserpine; schizophrenia; tardive dyskinesia