title: Sarcopenia as an Independent Risk Factor for Decreased BMD in COPD Patients: Korean National Health and Nutrition Examination Surveys IV and V (2008-2011).
abstract: BACKGROUND
  A decrease in bone mineral density (BMD) is a systemic consequence of chronic obstructive pulmonary disease (COPD). Past reports have rarely examined any correlation between sarcopenia and BMD. We investigated the relationship cross-sectionally between the presence of sarcopenia and BMD reduction in COPD patients.
  
  
  METHODS
  COPD patients aged 50 or older with qualifying spirometry and dual-energy X-ray absorptiometry data were from participants in the Korean National Health and Nutrition Examination Surveys IV and V (2008-2011).
  
  
  RESULTS
  There were 286 (33.3%) subjects in the sarcopenia group and 572 (66.7%) in the non-sarcopenia group. The sarcopenia group had lower T-scores than the non-sarcopenia group (femur: -0.73±0.88 vs. -0.18±0.97, p < 0.001; femur neck: -1.44±0.98 vs. -0.99±1.06, p < 0.001; lumbar: -1.38±1.36 vs. -0.84±1.38, p < 0.001). The prevalences of osteopenia and osteoporosis were 60.8% and 22.0%, respectively, in the sarcopenia group and 45.6% and 13.3% in the non-sarcopenia group (both p < 0.001). After adjusting for multiple variables, the presence of sarcopenia associated with increased the risk of osteopenia, osteoporosis, and a low BMD (OR = 3.227, 95% CI = 2.125-4.899, p < 0.001, OR = 6.952, 95% CI = 3.418-14.139, p < 0.001, and OR = 3.495, 95% CI = 2.315-5.278, p < 0.001, respectively). In a subgroup analysis, similar OR changes were confirmed in the high-body-weight group (n = 493) (OR = 2.248, 95% CI = 1.084-4.665, p = 0.030, OR = 4.621, 95% CI = 1.167-18.291, p = 0.029, and OR = 2.376, 95% CI = 1.158-4.877, p = 0.018, respectively).
  
  
  CONCLUSIONS
  The presence of sarcopenia was associated with increased the risk for decreased BMD in COPD.
authors.affiliation: Division of Pulmonology, Department of Internal Medicine, Andong Sungso Hospital, Andong, Korea.
authors.forename: Dong-Won
authors.initials: DW
authors.lastname: Lee
authors.affiliation: Division of Pulmonology and Allergy, Department of Internal Medicine, Yeungnam University Hospital, Daegu, Korea.
authors.forename: Eun-Young
authors.initials: EY
authors.lastname: Choi
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D044466:Asian People; D015992:Body Mass Index; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000150:complications / Q000453:epidemiology; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D016014:Linear Models; D008168:Lung / Q000000981:diagnostic imaging / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D016017:Odds Ratio; D010024:Osteoporosis / Q000150:complications / Q000453:epidemiology; D010281:Parathyroid Hormone / Q000097:blood; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000473:pathology*; D011788:Quality of Life; D056910:Republic of Korea; D012307:Risk Factors; D055948:Sarcopenia / Q000150:complications* / Q000453:epidemiology; D013147:Spirometry
chemical_list: D010281:Parathyroid Hormone