title: Mitoxantrone-Surfactant Interactions: A Physicochemical Overview.
abstract: Mitoxantrone is a synthetic anticancer drug used clinically in the treatment of different types of cancer. It was developed as a doxorubicin analogue in a program to find drugs with improved antitumor activity and decreased cardiotoxicity compared with the anthracyclines. As the cell membrane is the first barrier encountered by anticancer drugs before reaching the DNA sites inside the cells and as surfactant micelles are known as simple model systems for biological membranes, the drugs-surfactant interaction has been the subject of great research interest. Further, quantitative understanding of the interactions of drugs with biomimicking structures like surfactant micelles may provide helpful information for the control of physicochemical properties and bioactivities of encapsulated drugs in order to design better delivery systems with possible biomedical applications. The present review describes the physicochemical aspects of the interactions between the anticancer drug mitoxantrone and different surfactants. Mitoxantrone-micelle binding constants, partitions coefficient of the drug between aqueous and micellar phases and the corresponding Gibbs free energy for the above processes, and the probable location of drug molecules in the micelles are discussed.
authors.affiliation: Institute of Physical Chemistry Ilie Murgulescu, Romanian Academy, Splaiul Independentei 202, Bucharest 060021, Romania. enachemir@yahoo.com.
authors.forename: Mirela
authors.initials: M
authors.lastname: Enache
authors.affiliation: Institute of Physical Chemistry Ilie Murgulescu, Romanian Academy, Splaiul Independentei 202, Bucharest 060021, Romania. ancutatoader@yahoo.fr.
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Toader
authors.affiliation: Institute of Biology Bucharest, Romanian Academy, Splaiul Independentei 296, Bucharest 060031, Romania. madalin.enache@ibiol.ro.
authors.forename: Madalin Iancu
authors.initials: MI
authors.lastname: Enache
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D008823:Micelles; D008942:Mitoxantrone / Q000737:chemistry / Q000494:pharmacology*; D008954:Models, Biological; D008958:Models, Molecular; D013501:Surface-Active Agents / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D008823:Micelles; D013501:Surface-Active Agents; D008942:Mitoxantrone
keywords: binding constant; micelles; mitoxantrone; partition coefficient; surfactants