title: Solid organ transplant antibiograms: an opportunity for antimicrobial stewardship.
abstract: OBJECTIVE
  We aimed to compare the antimicrobial susceptibility percentages in blood and urine bacterial isolates recovered from solid organ transplant (SOT) recipients with those reported in the hospital-wide antibiogram.
  
  
  METHODS
  Retrospective review of the antimicrobial susceptibilities of bacterial isolates recovered from SOT recipients at a 1550-bed hospital over a 2-year period. Antibiograms were categorized by anatomic site (blood and urine). Percentage of bacterial susceptibilities to specific antibiotics were compared with the hospital-wide antibiogram.
  
  
  RESULTS
  A total of 1889 unique cultures were identified. Blood and urine isolates of Escherichia coli, Klebsiella pneumonia and Pseudomonas aeruginosa had significantly lower susceptibility to first and second line antibiotics compared to the hospital-wide antibiogram.
  
  
  CONCLUSIONS
  Significant differences in susceptibilities between isolates from blood and urine cultures from SOT recipients and the hospital-wide antibiogram were found. A population-based strategy for the development of antibiograms specific for this group of high-risk patients could better guide appropriate empiric antimicrobial selection.
authors.affiliation: Department of Medicine, Jackson Memorial Hospital, 1611 NW12th Avenue, Miami, FL, 33136; Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, 1120 NW 14th Street, Miami, FL, 33136. Electronic address: rossana.m.rosa@gmail.com.
authors.forename: Rossana
authors.initials: R
authors.lastname: Rosa
authors.affiliation: Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, 1120 NW 14th Street, Miami, FL, 33136.
authors.forename: Jacques
authors.initials: J
authors.lastname: Simkins
authors.affiliation: Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, 1120 NW 14th Street, Miami, FL, 33136.
authors.forename: Jose F
authors.initials: JF
authors.lastname: Camargo
authors.affiliation: Department of Pathology and Microbiology, University of Miami Miller School of Medicine, 1611 NW 12th Avenue, Miami, FL, 33136.
authors.forename: Octavio
authors.initials: O
authors.lastname: Martinez
authors.affiliation: Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, 1120 NW 14th Street, Miami, FL, 33136; Department of Infection Control and Antimicrobial Stewardship, Jackson Health System, 1611 NW 12th Avenue, Miami, FL, 33136.
authors.forename: Lilian M
authors.initials: LM
authors.lastname: Abbo
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016470:Bacteremia / Q000382:microbiology*; D004926:Escherichia coli / Q000187:drug effects* / Q000302:isolation & purification; D006761:Hospitals; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification; D012189:Retrospective Studies; D066027:Transplant Recipients; D019737:Transplants; D014552:Urinary Tract Infections / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents
keywords: Antibiogram; Antimicrobial susceptibility testing; Transplantation