title: EFFECT OF CHRONIC INGESTION OF WINE ON THE GLYCEMIC, LIPID AND BODY WEIGHT HOMEOSTASIS IN MICE.
abstract: The health benefits associated with moderate wine consumption, as with ethanol and phenolic compounds, include different mechanisms still little understandable.
  
  
  
  Evaluate glycemic and weight variations, and the deposit of triglycerides, cholesterol and liver glycogen with red wine consumption.
  
  
  
  60 ApoE knockout mice were divided into three groups of 20: Wine Group (WG), Ethanol Group (EG) and Water Group (WAG). They received daily: WG 50 ml of wine and 50 ml water; EG 6 ml ethanol and WAG 94 ml of water. All groups were followed for four months. The food intake was monitored daily, in the period from eight to ten hours and held every five days. The measurement of water intake was also made every five days. The weighing of the animals took place every ten days.
  
  
  
  The WG had higher weight increase as compared to the other groups. The concentration of hepatic triglyceride was higher in WG (57%) and the EG group was lower (31.6%, p<0.01) than the control. The concentration of cholesterol was lower in the WG (23.6%), as well as EG (24.5%, p<0.05). The concentration of glycogen was higher in WG (16%) and fasting blood glucose was higher in EG compared to the other groups but not both demonstrated a statistically significant difference.
  
  
  
  The WG increased triglyceride and WAG decreased cholesterol. The triglyceride may be increased due to the high caloric value of wine or some unknown property that led to significant increase in subcutaneous andretroperitoneal fat in mice.
authors.affiliation: Academic League in Experimental Surgery Laboratory, School of Medicine, Federal University of Maranhão and State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Sebastião Barreto de
authors.initials: SB
authors.lastname: Brito-Filho
authors.affiliation: Academic League in Experimental Surgery Laboratory, School of Medicine, Federal University of Maranhão and State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Egberto Gaspar de
authors.initials: EG
authors.lastname: Moura
authors.affiliation: Academic League in Experimental Surgery Laboratory, School of Medicine, Federal University of Maranhão and State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Orlando José Dos
authors.initials: OJ
authors.lastname: Santos
authors.affiliation: Academic League in Experimental Surgery Laboratory, School of Medicine, Federal University of Maranhão and State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Euler Nicolau
authors.initials: EN
authors.lastname: Sauaia-Filho
authors.affiliation: Academic League in Experimental Surgery Laboratory, School of Medicine, Federal University of Maranhão and State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Elias
authors.initials: E
authors.lastname: Amorim
authors.affiliation: Academic League in Experimental Surgery Laboratory, School of Medicine, Federal University of Maranhão and State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Ewaldo Eder Carvalho
authors.initials: EE
authors.lastname: Santana
authors.affiliation: Academic League in Experimental Surgery Laboratory, School of Medicine, Federal University of Maranhão and State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Allan Kardec Dualibe
authors.initials: AK
authors.lastname: Barros-Filho
authors.affiliation: Academic League in Experimental Surgery Laboratory, School of Medicine, Federal University of Maranhão and State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Rennan Abud Pinheiro
authors.initials: RA
authors.lastname: Santos
mesh_terms: D000428:Alcohol Drinking / Q000097:blood* / Q000503:physiopathology*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D001835:Body Weight; D002784:Cholesterol / Q000097:blood*; D002908:Chronic Disease; D006706:Homeostasis; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D014280:Triglycerides / Q000097:blood*; D014920:Wine
chemical_list: D001786:Blood Glucose; D014280:Triglycerides; D002784:Cholesterol