title: Radial artery vasomotor function following transradial cardiac catheterisation.
abstract: To determine the reproducibility of flow-mediated dilation (FMD) and nitrate-mediated dilation (NMD) in the assessment of radial artery vasomotor function, and to examine the effect of transradial catheterisation on radial artery injury and recovery.
  
  
  
  Radial artery FMD and NMD were examined in 20 volunteers and 20 patients on four occasions (two visits at least 24 hours apart, with two assessments at each visit). In a further 10 patients, radial artery FMD was assessed in the catheterised arm prior to, at 24 hours and 3 months following cardiac catheterisation.
  
  
  
  There were no differences in baseline radial artery diameter (2.7±0.4 mm vs 2.7±0.4 mm), FMD (13.4±6.4 vs 12.89±5.5%) or NMD (13.6±3.8% vs 10.1±4.3%) between healthy volunteers and patients (p>0.05 for all comparisons). Mean differences for within and between day FMD were 2.53% (95% CIs -15.5% to 20.5%) and -4.3% (-18.3% to 9.7%) in patients. Compared to baseline, radial artery FMD was impaired at 24 hours (8.7±4.1% vs 3.9±2.9%, p=0.015) but not 3 months (8.7±4.1% vs 6.2±4.4, p=0.34) following transradial catheterisation.
  
  
  
  Radial FMD is impaired early after transradial catheterisation but appears to recover by 3 months. While test-retest variability was demonstrated, our findings suggest that transradial access for cardiac catheterisation may afford a potential model of vascular injury and repair in vivo in man.
authors.affiliation: Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK; Edinburgh Heart Centre, NHS Lothian, Edinburgh, UK.
authors.forename: A J
authors.initials: AJ
authors.lastname: Mitchell
authors.affiliation: Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK; Edinburgh Heart Centre, NHS Lothian, Edinburgh, UK.
authors.forename: N L
authors.initials: NL
authors.lastname: Mills
authors.affiliation: Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK; Edinburgh Heart Centre, NHS Lothian, Edinburgh, UK.
authors.forename: D E
authors.initials: DE
authors.lastname: Newby
authors.affiliation: Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK; Edinburgh Heart Centre, NHS Lothian, Edinburgh, UK.
authors.forename: N L M
authors.initials: NL
authors.lastname: Cruden
keywords: Flow-mediated dilatation; Transradial catheterisation; Vascular injury