title: Relationship of Liver X Receptors α and Endoglin Levels in Serum and Placenta with Preeclampsia.
abstract: BACKGROUND
  Liver X receptor alpha (LXRα) and endoglin have been postulated to play roles in trophoblast invasion and lipid metabolic disturbances. However, the relationship between LXRα and endoglin levels in serum and placenta of patients with preeclampsia remains poorly understood. The objective of this study was to identify correlations between LXRα, endoglin and preeclampsia and provide new feasible methods of clinical prediction and treatment for preeclampsia.
  
  
  METHODS
  We enrolled 45 patients with preeclampsia (24 with moderate preeclampsia and 21 with severe preeclampsia) and 15 normal pregnant women (control group) who were admitted to the Department of Obstetrics of the General Hospital of Beijing Command between October 2012 and July 2013 in this study. Serum and placental LXRα and endoglin levels were analyzed by enzyme-linked immunosorbent assay, real-time quantitative PCR, tissue microarray and immunohistochemistry.
  
  
  RESULTS
  Serum and placental LXRα and endoglin levels were significantly higher in patients with preeclampsia than those in control group (P<0.05, each). Moreover, patients with severe preeclampsia displayed significantly higher LXRα and endoglin levels than those with moderate preeclampsia (P<0.05, each). The LXRα sensitivity, specificity and positive and negative predictive values were 66.00%, 80.00%, 89.19% and 48.48%, respectively, while those of endoglin levels were 62.00%, 85.00%, 91.18% and 47.22%, respectively. LXRα and endoglin levels in serum and placenta from patients with preeclampsia were positively correlated (serum: r = 0.486, P<0.01; placenta: r = 0.569, P<0.01).
  
  
  CONCLUSIONS
  Elevated LXRα and endoglin levels may be associated with preeclampsia pathogenesis and development and could be used as potential predictors for this disorder.
authors.affiliation: Department of Obstetrics and Gynecology, General Hospital of Beijing Military Command, Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of General Surgery, General Hospital of Beijing Military Command, Beijing, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Dong
authors.affiliation: Department of Obstetrics and Gynecology, General Hospital of Beijing Military Command, Beijing, China.
authors.forename: Hong-Yan
authors.initials: HY
authors.lastname: Wu
authors.affiliation: Department of Obstetrics and Gynecology, General Hospital of Beijing Military Command, Beijing, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Wu
authors.affiliation: Department of Obstetrics and Gynecology, General Hospital of Beijing Military Command, Beijing, China.
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics and Gynecology, General Hospital of Beijing Military Command, Beijing, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology, General Hospital of Beijing Military Command, Beijing, China.
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Shang
mesh_terms: D000328:Adult; D000071063:Endoglin / Q000032:analysis* / Q000097:blood* / Q000235:genetics; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D000071518:Liver X Receptors / Q000032:analysis* / Q000097:blood* / Q000235:genetics; D010920:Placenta / Q000378:metabolism / Q000473:pathology*; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D011247:Pregnancy; D055815:Young Adult
chemical_list: D000071063:Endoglin; D000071518:Liver X Receptors