title: ULTRA-WIDE-FIELD FUNDUS AUTOFLUORESCENCE FINDINGS IN PATIENTS WITH ACUTE ZONAL OCCULT OUTER RETINOPATHY.
abstract: OBJECTIVE
  To determine whether ultra-wide-field fundus autofluorescence (UWFFAF) findings in acute zonal occult outer retinopathy correlated well with perimetry, optical coherence tomography, and electroretinography findings.
  
  
  METHODS
  Retrospective observational study on 16 eyes of 10 subjects with AZOOR seen at a single referral center from October 2012 to March 2015 who had UWFFAF performed. Chi-square analysis was performed to compare categorical variables, and Mann-Whitney U test used for comparisons of nonparametric continuous variables.
  
  
  RESULTS
  All eyes examined within 3 months of symptom onset (five of the five eyes) had diffusely hyperautofluorescent areas on UWFFAF. The remaining eyes contained hypoautofluorescent lesions with hyperautofluorescent borders. In 11/16 (68.8%) eyes, UWFFAF showed the full extent of lesions that would not have been possible with standard fundus autofluorescence centered on the fovea. There were 3 patterns of spread: centrifugal spread (7/16, 43.8%), centripetal spread (5/16, 31.3%), and centrifugal + centripetal spread (4/16, 25.0%). The UWFFAF lesions corresponded well with perimetric, optical coherence tomography, and electroretinography abnormalities.
  
  
  CONCLUSIONS
  The UWFFAF along with optical coherence tomography can be useful in the evaluation and monitoring of acute zonal occult outer retinopathy patients.
authors.affiliation: *Wilmer Eye Institute Johns Hopkins University School of Medicine, Baltimore, MD; and †the Casey Eye Institute, Oregon Health & Science University, Portland, Oregon.
authors.forename: Amde Selassie
authors.initials: AS
authors.lastname: Shifera
authors.forename: Mark E
authors.initials: ME
authors.lastname: Pennesi
authors.forename: Paul
authors.initials: P
authors.lastname: Yang
authors.forename: Phoebe
authors.initials: P
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004596:Electroretinography; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D005584:Fovea Centralis / Q000473:pathology*; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012607:Scotoma / Q000175:diagnosis* / Q000503:physiopathology; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity; D014794:Visual Fields; D000080363:White Dot Syndromes; D055815:Young Adult