title: Peritoneal dialysis in patients with failed kidney transplant: Single centre experience.
abstract: OBJECTIVE
  To determine if patients with failing kidney transplants who opt to have peritoneal dialysis (PD) have poor short-term PD technique survival and increased rates of peritonitis.
  
  
  METHODS
  We performed a retrospective analysis comparing 50 consecutive patients starting PD after a failed kidney transplant to 93 incident patients starting PD (matching for age, gender, diabetes causing renal failure, ethnicity and year of starting PD).
  
  
  RESULTS
  The mean follow-up period was 26 months. PD technique survival was lower for the post-transplant cohort. However, this did not appear to be related to PD peritonitis risk; infection rate was lower in the post-transplant group albeit not statistically significant (1 in 23.6 patient months vs 1 in 22.5 patient months). There were no differences in the proportion of Gram positive: Gran negative: Culture Negative infections. The only fungal peritonitis occurred in a Control patient. Results of baseline Peritoneal Equilibration Tests were not different; D/Pcr was 0.69 for post-TP versus 0.64 for Control (P = ns), and net UF was 250 mL for post-TP versus 310 mL for Control (P = ns). PET results after 12 months were also similar.
  
  
  CONCLUSIONS
  Our study found a small but significantly higher rate of PD technique failure in the post-transplant cohort, but this did not appear to be related to peritonitis rates or peritoneal membrane function. Further studies are required to explore reasons for PD technique failure in patients who have had kidney transplant, but our study supports the use of PD in selected patient from this cohort.
authors.affiliation: Department of Renal Medicine and Transplantation, Barts Health NHS Trust, London, UK.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Chaudhri
authors.affiliation: Department of Renal Medicine and Transplantation, Barts Health NHS Trust, London, UK.
authors.forename: Alice A
authors.initials: AA
authors.lastname: Thomas
authors.affiliation: Department of Renal Medicine and Transplantation, Barts Health NHS Trust, London, UK.
authors.forename: Nasreen
authors.initials: N
authors.lastname: Samad
authors.affiliation: Department of Renal Medicine and Transplantation, Barts Health NHS Trust, London, UK.
authors.forename: Stanley L
authors.initials: SL
authors.lastname: Fan
mesh_terms: D000328:Adult; D018572:Disease-Free Survival; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology; D006801:Humans; D053208:Kaplan-Meier Estimate; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000401:mortality; D008131:London; D008297:Male; D008567:Membranes, Artificial; D009181:Mycoses / Q000382:microbiology; D010530:Peritoneal Dialysis / Q000009:adverse effects* / Q000295:instrumentation / Q000401:mortality; D010538:Peritonitis / Q000382:microbiology; D011183:Postoperative Complications / Q000209:etiology* / Q000382:microbiology / Q000401:mortality / Q000628:therapy; D016016:Proportional Hazards Models; D006435:Renal Dialysis; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D017211:Treatment Failure
chemical_list: D008567:Membranes, Artificial
keywords: immunosupression; kidney transplantation; peritoneal dialysis; peritonitis; technique survival