title: Bone measurements of infants with hyperbilirubinemia by quantitative ultrasound: the influence of phototherapy.
abstract: OBJECTIVE
  The purpose of the current study was to investigate the possible effects of phototherapy on bone status of term infants evaluated by measurement of tibial bone speed of sound (SOS).
  
  
  METHODS
  The phototherapy group (n = 30) consisted of children who had undergone phototherapy for at least 24 h and the control group (n = 30) comprised children who had not received phototherapy. Blood samples were obtained from all infants for serum calcium, phosphorus, magnesium, alkaline phosphatase, parathyroid hormone and vitamin D concentrations. The left tibial quantitative ultrasound (QUS) measurements were performed using a commercial device.
  
  
  RESULTS
  There was no statistically significant difference between phototherapy-exposed and nonexposed infants in terms of Ca, P, ALP, PTH and vitamin D levels. Comparison of bone SOS between the phototherapy-exposed and control group revealed no statistically difference. Also, no significant difference in Z-score for SOS was observed between those with or without exposure.
  
  
  CONCLUSIONS
  The data of our study indicate that phototherapy treatment has no impact on bone status in the hyperbilirubinemic infants. Although there is no statistically significant evidence of an excess risk of bone damage following phototherapy, studies with larger sample sizes and longer duration of follow-up are needed to gain a better understanding of its effects.
authors.affiliation: a Department of Pediatrics , Ankara Training and Research Hospital , Ankara , Turkey.
authors.forename: Fatma İnci
authors.initials: Fİ
authors.lastname: Arıkan
authors.affiliation: b Department of Neonatology , Ortadoğu Hospital , Ankara , Turkey , and.
authors.forename: Semra
authors.initials: S
authors.lastname: Kara
authors.affiliation: c Department of Pediatrics , Kütahya Training and Research Hospital , Ankara , Turkey.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Bilgin
authors.affiliation: a Department of Pediatrics , Ankara Training and Research Hospital , Ankara , Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Özkan
authors.affiliation: a Department of Pediatrics , Ankara Training and Research Hospital , Ankara , Turkey.
authors.forename: Yıldız Dallar
authors.initials: YD
authors.lastname: Bilge
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001846:Bone Development; D016022:Case-Control Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D006932:Hyperbilirubinemia / Q000097:blood / Q000628:therapy*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010789:Phototherapy / Q000009:adverse effects*; D011247:Pregnancy; D012307:Risk Factors; D013977:Tibia / Q000000981:diagnostic imaging*; D014463:Ultrasonography / Q000379:methods; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: Neonatal jaundice; bone damage; phototherapy; quantitative ultrasound