title: 18F-FDG uptake in the stomach on screening PET/CT: value for predicting Helicobacter pylori infection and chronic atrophic gastritis.
abstract: The aim of this study was to determine the value of18F-FDG uptake on screening PET/CT images for the prediction of Helicobacter pylori (H. pylori) infection and chronic atrophic gastritis.
  
  
  
  Among subjects who underwent18F-FDG PET/CT for cancer screening from April 2005 to November 2015, PET/CT images were analyzed in 88 subjects who had gastrointestinal fiberscopy within 6 months. The volumes of interest (VOIs) were placed in the fornix, corpus and antrum of the stomach to determine maximal standardized uptake value (SUVmax) and mean SUV (SUVmean). Receiver operating characteristic curve (ROC) analysis was performed to determine the diagnostic performance of SUV indicators in predicting H. pylori infection and chronic atrophic gastritis.
  
  
  
  SUV indicators of the stomach were significantly higher in subjects with H. pylori infection than those without (from P < 0.001 to P < 0.05). ROC analysis revealed that SUVmean had the highest performance in predicting H. pylori infection (AUC 0.807) and chronic atrophic gastritis (AUC 0.784). SUVmean exhibited the sensitivity of 86.5 % and the specificity of 70.6 % in predicting H. pylori infection, and the sensitivity of 75.0 % and 78.6 % in predicting chronic atrophic gastritis.
  
  
  
  Assessment of18F-FDG uptake in the stomach reflecting active inflammation is useful in predicting patients with H. pylori infection and subsequent chronic atrophic gastritis which is closely associated with the risk of gastric neoplasms.
authors.affiliation: Center for Preventive Medicine, Mie University Hospital, 2-174 Edobashi, Tsu, Mie, Pref. 514-8507, Japan. skhousya@clin.medic.mie-u.ac.jp.
authors.forename: Shigeki
authors.identifier: 0000-0002-8411-0682
authors.initials: S
authors.lastname: Kobayashi
authors.affiliation: Center for Preventive Medicine, Mie University Hospital, 2-174 Edobashi, Tsu, Mie, Pref. 514-8507, Japan.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Ogura
authors.affiliation: Department of Radiology, Mie University Hospital, 2-174 Edobashi, Tsu, Mie, Pref. 514-8507, Japan.
authors.forename: Naohisa
authors.initials: N
authors.lastname: Suzawa
authors.affiliation: Department of Gastroenterology and Hepatology, Mie University Hospital, 2-174 Edobashi, Tsu, Mie, Pref. 514-8507, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Horiki
authors.affiliation: Department of Gastroenterology and Hepatology, Mie University Hospital, 2-174 Edobashi, Tsu, Mie, Pref. 514-8507, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Katsurahara
authors.affiliation: Clinical Research Support Center, Mie University Hospital, 2-174 Edobashi, Tsu, Mie, Pref. 514-8507, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Ogura
authors.affiliation: Department of Radiology, Mie University Hospital, 2-174 Edobashi, Tsu, Mie, Pref. 514-8507, Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Sakuma
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D005757:Gastritis, Atrophic / Q000000981:diagnostic imaging* / Q000378:metabolism; D016481:Helicobacter Infections / Q000000981:diagnostic imaging* / Q000378:metabolism; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: 18F-FDG PET/CT; Chronic atrophic gastritis; Helicobacter pylori infection