title: Evaluation of gastric blood supply in diabetic patients with gastroparesis by contrast-enhanced ultrasound.
abstract: OBJECTIVE
  Improvement in regional blood flow has been shown to ameliorate diabetic gastroparesis. We compared the gastric blood supply in patients with diabetes with gastroparesis with that in healthy subjects, by using contrast-enhanced ultrasound (CEUS).
  
  
  METHODS
  30 healthy subjects and 40 patients with diabetic gastroparesis were enrolled. The CEUS parameters of greater curvatures of the antrum (GCOA) and lesser curvatures of the antrum (LCOA), including peak intensity (PI) and the area under the curve (AUC), were compared between the two groups.
  
  
  RESULTS
  Intraclass correlation coefficient (ICC) for PI in healthy subjects measured on CEUS were 0.831-0.857 and 0.803-0.823, respectively. Intra-ICC and inter-ICC values for AUC were 0.805-0.823 and 0.813-0.815, respectively. In both groups, no significant difference was observed in PI and AUC values of GCOA and LCOA (p > 0.05). The PI and AUC of GCOA and LCOA in the diabetes group were less than those in the normal group (p < 0.05).
  
  
  CONCLUSIONS
  CEUS can assess stomach wall vascularity with a high reproducibility. Microcirculation in the antrum of patients with diabetic gastroparesis is poorer than that of normal group, which is consistent with the mechanisms of diabetic neuropathy. CEUS can be used for evaluation of microvascular perfusion in patients with stomach wall disease. Advances in knowledge: This was the first study to use CEUS for assessment of blood supply of the gastric wall and to compare microvascular perfusion between healthy individuals and patients with diabetes with gastroparesis.
authors.affiliation: 1 Department of Ultrasound, Zhangzhou Hospital, Fujian Medical University, Zhangzhou, Fujian, China.
authors.forename: Hao-Lin
authors.initials: HL
authors.lastname: Shen
authors.affiliation: 1 Department of Ultrasound, Zhangzhou Hospital, Fujian Medical University, Zhangzhou, Fujian, China.
authors.forename: Shu-Ping
authors.initials: SP
authors.lastname: Yang
authors.affiliation: 1 Department of Ultrasound, Zhangzhou Hospital, Fujian Medical University, Zhangzhou, Fujian, China.
authors.forename: Kang-Jian
authors.initials: KJ
authors.lastname: Wang
authors.affiliation: 1 Department of Ultrasound, Zhangzhou Hospital, Fujian Medical University, Zhangzhou, Fujian, China.
authors.forename: Bei-Lei
authors.initials: BL
authors.lastname: Huang
authors.affiliation: 2 Department of Gastroenterology, Zhangzhou Hospital, Fujian Medical University, Zhangzhou, Fujian, China.
authors.forename: Wen-Bao
authors.initials: WB
authors.lastname: Huang
authors.affiliation: 3 Department of Endocrinology, Zhangzhou Hospital, Fujian Medical University, Zhangzhou, Fujian, China.
authors.forename: Jin-Zhi
authors.initials: JZ
authors.lastname: Wu
authors.affiliation: 4 Department of Ultrasound, Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China.|5 Department of Clinical Medicine, Quanzhou Medical College, Quanzhou, Fujian, China.
authors.forename: Guo-Rong
authors.initials: GR
authors.lastname: Lv
mesh_terms: D000328:Adult; D019540:Area Under Curve; D003287:Contrast Media; D048909:Diabetes Complications / Q000000981:diagnostic imaging*; D005260:Female; D018589:Gastroparesis / Q000000981:diagnostic imaging*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow; D015203:Reproducibility of Results; D013270:Stomach / Q000098:blood supply* / Q000000981:diagnostic imaging*; D014463:Ultrasonography
chemical_list: D003287:Contrast Media