title: Factors Associated with Frontotemporal Dementia in China: A Cross-Sectional Study.
abstract: There is a growing focus on frontotemporal dementia (FTD). However, compared with other major dementias, very little is known about the factors associated with FTD. The present study evaluated candidate factors associated with FTD in the Chinese population.
  
  
  
  One hundred eight elderly patients (36 diagnosed with FTD and 72 controls) of the Neurology Central Hospital of Tianjin (China), were diagnosed by neurologists, and recruited for the study between November 2011 and November 2014. Clinical evaluation, laboratory tests, brain images (computed tomography scans and magnetic resonance images), neuropsychological, and neuropsychiatric assessments were performed. The association between FTD and the variables was assessed using multiple binary logistic regression analyses adjusted for age and gender.
  
  
  
  With controls as the reference category, education was associated with the diagnosis of FTD (adjusted odds ratio [OR], 1.60; 95% confidence interval [CI]: 1.17-2.19). Serum vitamin B12levels were associated with the diagnosis of FTD (adjusted OR, 0.99; 95% CI: 0.98-0.99). Serum low-density lipoprotein (LDL) levels were associated with the diagnosis of FTD (adjusted OR, 8.54; 95% CI: 2.86-25.49).
  
  
  
  Education and serum LDL levels were positively associated with the diagnosis of FTD. Serum vitamin B12levels were negatively associated with the diagnosis of FTD.
authors.affiliation: School of Nursing, Tianjin Medical University, Tianjin, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Neurology, and Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Liu
authors.affiliation: Metabolic Diseases Hospital and Tianjin Institute of Endocrinology, Tianjin, China.
authors.forename: Miaoyan
authors.initials: M
authors.lastname: Zheng
authors.affiliation: Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Ji
authors.affiliation: Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, China.
authors.forename: Tianfeng
authors.initials: T
authors.lastname: Wu
authors.affiliation: Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, China.
authors.forename: Guowei
authors.initials: G
authors.lastname: Huang
authors.affiliation: Department of Neurology, and Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Ji
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D003704:Dementia / Q000175:diagnosis; D004522:Educational Status; D005260:Female; D057180:Frontotemporal Dementia / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D016017:Odds Ratio; D014805:Vitamin B 12 / Q000097:blood
chemical_list: D008077:Lipoproteins, LDL; D014805:Vitamin B 12
keywords: Education; Frontotemporal dementia; Low-density lipoprotein; Neurological disorders; Vitamin B(12)