title: Cobalt-Catalyzed Reductive Multicomponent Synthesis of β-Hydroxy- and β-Aminocarbonyl Compounds under Mild Conditions.
abstract: The cobalt-catalyzed multicomponent reaction between sp2-hybridized organic halides, Michael acceptors, and unsaturated electrophiles has been developed. The reaction proceeds through a formal conjugate addition/aldol or aza-aldol (Mannich) tandem reaction initiated by the in situ metalation of the organic halide by cobalt catalysis. The essentially new reaction conditions that have been developed are very mild and atom-economic. Under these conditions, a broad range of β-hydroxy- and β-aminocarbonyl compounds are obtained in good to high yields.
authors.affiliation: Électrochimie et Synthèse Organique, Université Paris Est, ICMPE (UMR 7182), CNRS, UPEC, 2-8 rue Henri Dunant, 94320, Thiais, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Paul
authors.affiliation: Électrochimie et Synthèse Organique, Université Paris Est, ICMPE (UMR 7182), CNRS, UPEC, 2-8 rue Henri Dunant, 94320, Thiais, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Presset
authors.affiliation: Électrochimie et Synthèse Organique, Université Paris Est, ICMPE (UMR 7182), CNRS, UPEC, 2-8 rue Henri Dunant, 94320, Thiais, France.|Institut des Sciences Moléculaires, UMR-CNRS 5255, Université de Bordeaux, 351, Cours de la Libération, 33405, Talence Cedex, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Cantagrel
authors.affiliation: Électrochimie et Synthèse Organique, Université Paris Est, ICMPE (UMR 7182), CNRS, UPEC, 2-8 rue Henri Dunant, 94320, Thiais, France.
authors.forename: Erwan
authors.initials: E
authors.lastname: Le Gall
authors.affiliation: Électrochimie et Synthèse Organique, Université Paris Est, ICMPE (UMR 7182), CNRS, UPEC, 2-8 rue Henri Dunant, 94320, Thiais, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Léonel
keywords: aryl halides; cobalt; homogeneous catalysis; hydroxycarbonyl compounds; multicomponent reactions