title: Vertical Transmission of PCV2b to Fetuses in Sows Intramuscularly Infected with PCV2b.
abstract: In order to investigate whether PCV2b can be transmitted across the placenta in sows thereby causing vertical infection of fetuses, six sows in 75 day of pregnancy were either intramuscularly inoculated with a PCV2b culture supernatant (n = 4) or mock infected with cell culture supernatant (n = 2). At parturition, 3 newborn piglets from each litter were randomly selected and euthanatized prior to suckling. Samples of the mesenteric lymph nodes, spleens, kidneys, hearts and lungs were collected for PCR, histopathological and immunohistochemical assays. The results showed that the newborn piglets from PCV2b-infected sows had histopathological lesions in the tested tissues. Moreover, PCV2b antigen and DNA were detected as well. These findings therefore suggested that porcine circovirus type 2b can be transmitted across the placenta of sows, thereby leading to PCV2b vertical infection of the fetuses.
authors.forename: Wang Nai
authors.initials: WN
authors.lastname: Dong
authors.forename: Li Jing
authors.initials: LJ
authors.lastname: Jun
authors.forename: Wang Ai
authors.initials: WA
authors.lastname: Bing
authors.forename: Zhu
authors.initials: Z
authors.lastname: Zhe
authors.forename: Chang
authors.initials: C
authors.lastname: Yan
authors.forename: Mao
authors.initials: M
authors.lastname: Yu
authors.forename: Zan
authors.initials: Z
authors.lastname: Yang
authors.forename: Wang Zan
authors.initials: WZ
authors.lastname: Feng
authors.forename: Deng Zhi
authors.initials: DZ
authors.lastname: Bang
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000097:blood; D018173:Circoviridae Infections / Q000662:veterinary* / Q000821:virology; D017925:Circovirus / Q000145:classification; D005260:Female; D007074:Immunoglobulin G / Q000097:blood; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000662:veterinary* / Q000821:virology; D013552:Swine; D013553:Swine Diseases / Q000635:transmission / Q000821:virology*
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G