title: The effect of green tea consumption on oxidative stress markers and cognitive function in patients with Alzheimer's disease: A prospective intervention study.
abstract: BACKGROUND
  Alzheimer's disease (AD) is the most prevalent degenerative disorder of the brain among elderly individuals. Many studies indicate that oxidative stress is an important pathogenic factor which involves oxidizing macromolecules such as DNA, lipids, and proteins in AD. Green tea is a rich source of antioxidant compounds that can remove radical oxygen species. The purpose of this study was to investigate the influence of green tea consumption on markers of oxidative stress in AD.
  
  
  METHODS
  In this prospective intervention study, 30 patients with severe AD were recruited. The diagnosis of AD was made based on the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's disease and Related Disorders Association (NINCDS/ADRDA) criteria. Brain magnetic resonance imaging (MRI) and computed tomography (CT) scan as well as Mini-Mental State Examination (MMSE) were performed for all participants in which four green tea pills were administered daily for 2 months (2 g/day in 2 divided doses). The plasma total antioxidant capacity, 8-hydroxy-2'-deoxyguanosine levels (8-OHdG), malondialdehyde (MDA), carbonyl content, and MMSE scores were measured at baseline and at the end of the study period.
  
  
  RESULTS
  The levels of MDA, 8-OHdG and carbonyl decreased significantly as compared to baseline values (P=0.002, P=0.001 and P=0.037, respectively). Whereas, the total antioxidant capacity of plasma and MMSE scores significantly increased at end point (P=0.000, P=0.043, respectively).
  
  
  CONCLUSIONS
  The findings indicate that consumption of green tea for two months by with the improvement of antioxidant system exerts beneficial effect on cognitive function.
authors.affiliation: Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Horrolein
authors.initials: H
authors.lastname: Arab
authors.affiliation: Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.; Based Health Products Research Center, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Soleiman
authors.initials: S
authors.lastname: Mahjoub
authors.affiliation: Department of Social Medicine and Health, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Karimollah
authors.initials: K
authors.lastname: Hajian-Tilaki
authors.affiliation: Department of Neurology, Mehr-Avaran-Shomal Nursing Home, Sari, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Moghadasi
keywords: Alzheimer’s disease; Antioxidants; Cognitive function.; Green tea; Oxidative stress