title: Association between microRNA-27a rs895819 polymorphism and risk of colorectal cancer: A meta-analysis.
abstract: Colorectal cancer (CRC) is the most common malignancy in the human digestive system. Previous results regarding the association between microRNA-27a rs895819 polymorphisms and CRC risk are controversial. We therefore performed a meta-analysis of seven studies totaling 2230 cases and 2775 controls to systematically evaluate this association. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were obtained using a fixed-effects model. A moderate evidence for the association between mir-27a polymorphism and CRC risk was found under multiple genetic models (dominant model: OR = 1.15, 95% CI: 1.02-1.29, p = 0.02; recessive model: OR = 1.49, 95% CI: 1.27-1.76, p <0.001; homozygote model: OR = 1.53, 95% CI: 1.28-1.83, p <0.001; allele model: OR = 1.21, 95% CI: 1.11-1.31, p <0.001). Subgroup analysis showed a significant association between mir-27a rs895819 polymorphism and CRC risk among Chinese populations. On the contrary, we found no evidence of association among Caucasian populations due to small samples (p > 0.05). In conclusion, this meta-analysis suggested that rs895819 polymorphism in mir-27a may be a potential genetic risk factor for CRC, particularly in Chinese populations.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Wuhan University, No. 115 Donghu Road, Wuhan 430071, China; Global Health Institute, Wuhan University, No. 115 Donghu Road, Wuhan 430071, China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Liu
authors.affiliation: Duke Kunshan University, No. 8 Duke Avenue, Kunshan 215316, China.
authors.forename: Keith
authors.initials: K
authors.lastname: Dear
authors.affiliation: Zhoushan Entry-Exit Inspection and Quarantine Bureau of China, No. 555 Haijing Road, Zhoushan 316000, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Huang
authors.affiliation: Department of Epidemiology and Biostatistics and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan 430030, China.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Epidemiology and Biostatistics and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan 430030, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Epidemiology and Biostatistics and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan 430030, China.
authors.forename: Shaofa
authors.initials: S
authors.lastname: Nie
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Wuhan University, No. 115 Donghu Road, Wuhan 430071, China; Global Health Institute, Wuhan University, No. 115 Donghu Road, Wuhan 430071, China.
authors.forename: Yisi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Environmental Health Laboratory, Department of Public Health Sciences, University of Hawaii at Manoa, 1960 East West Rd, Biomed Bldg, D105, Honolulu, HI 96822, USA.
authors.forename: Yuanan
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Wuhan University, No. 115 Donghu Road, Wuhan 430071, China; Global Health Institute, Wuhan University, No. 115 Donghu Road, Wuhan 430071, China. Electronic address: xianghao@whu.edu.cn.
authors.forename: Hao
authors.initials: H
authors.lastname: Xiang
mesh_terms: D015179:Colorectal Neoplasms / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: C531388:MIRN27 microRNA, human; D035683:MicroRNAs
keywords: Mir-27a; colorectal cancer; meta-analysis; polymorphism