title: Breath-holding test in evaluation of peripheral chemoreflex sensitivity in healthy subjects.
abstract: The aim of the study was to determine the feasibility of using a breath-holding test in assessing the sensitivity of the peripheral chemoreflex compared with the single-breath carbon dioxide test. The study involved 48 healthy volunteers between the ages of 18-29 years. The breath-holding test was performed followed by the single-breath carbon dioxide test on the next day. A month after the first tests, these tests were repeated to evaluate their reproducibility The coefficient of variability in the single-breath carbon dioxide test ranged from 0 to 32% with a mean of 10±7%. The mean coefficient of variability of the breath-holding test was 6±4% (0-19%). A significant inverse correlation between the results of the two tests was noted following analysis (r=-0.82, p<0.05).
  
  
  
  A breath-holding test after deep inspiration reflects the sensitivity of the peripheral chemoreflex as defined by the single-breath carbon dioxide test in healthy subjects.
authors.affiliation: Kuban State Medical University, 350012, Krasnodar, Sedin str., 4, Russian Federation. Electronic address: nikitkax@mail.ru.
authors.forename: Nikita
authors.initials: N
authors.lastname: Trembach
authors.affiliation: Kuban State Medical University, 350012, Krasnodar, Sedin str., 4, Russian Federation.
authors.forename: Igor
authors.initials: I
authors.lastname: Zabolotskikh
mesh_terms: D000293:Adolescent; D000328:Adult; D062485:Breath Holding; D002245:Carbon Dioxide; D002628:Chemoreceptor Cells / Q000502:physiology*; D005240:Feasibility Studies; D006801:Humans; D012018:Reflex; D015203:Reproducibility of Results; D055815:Young Adult
chemical_list: D002245:Carbon Dioxide
keywords: Breath-holding test; Peripheral chemoreflex sensitivity; Single-breath carbon dioxide test