title: Perspectives in the application of residual dipolar couplings in the structure elucidation of weakly aligned small molecules.
abstract: This perspective article aims to review the general methodology in the application of residual dipolar couplings (RDCs) in the structure elucidation of small molecules and give the author's view on challenges for future applications. Recent improvements in the availability of alignment media, new pulse sequences for the measurement of couplings and improvements in the analysis software have garnered widespread interest in the technique. However, further generalization is needed in order to make RDC analysis into a truly "routine" method. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Clemens-Schöpf-Institut für Organische Chemie und Biochemie, Technische Universität Darmstadt, Darmstadt, Germany.
authors.forename: Volker
authors.identifier: http://orcid.org/0000-0002-7195-312X
authors.initials: V
authors.lastname: Schmidts
keywords: 13C; 1H; NMR; configurational assignment; conformational analysis; perspectives; residual dipolar couplings; small molecules; structural elucidation