title: [Towards new targets in the treatment of hypertension?]
abstract: Blood pressure is a major determinant of cardiovascular risk. Blood pressure target to reach with antihypertensive therapy, and the population to whom it should apply, remain debatted. Blood pressure goals established by scientific societies may be revised after the publication of the US multicenter SPRINT study results (Systolic Blood Pressure Intervention Trial) obtained in 2015. Analysis of the generalizability of the SPRINT results shows that they may not be directly applied to the french population which is at lower risk than the US population and would have major medical and economic implications.
authors.affiliation: Unité d'hypertension artérielle, Hôpital Européen Georges Pompidou, AP-HP, 20, rue Leblanc, 75015 Paris Paris, France ; Centre d'investigation clinique (CIC 1418), Hôpital Européen Georges Pompidou, AP-HP, Paris, 20, rue Leblanc, 75015 Paris France ; Université Paris-Descartes, Paris, France.
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Faucon
authors.affiliation: Unité d'hypertension artérielle, Hôpital Européen Georges Pompidou, AP-HP, 20, rue Leblanc, 75015 Paris Paris, France ; Centre d'investigation clinique (CIC 1418), Hôpital Européen Georges Pompidou, AP-HP, Paris, 20, rue Leblanc, 75015 Paris France ; Université Paris-Descartes, Paris, France.
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Madjalian
authors.affiliation: Unité d'hypertension artérielle, Hôpital Européen Georges Pompidou, AP-HP, 20, rue Leblanc, 75015 Paris Paris, France ; Centre d'investigation clinique (CIC 1418), Hôpital Européen Georges Pompidou, AP-HP, Paris, 20, rue Leblanc, 75015 Paris France ; Université Paris-Descartes, Paris, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Bobrie
authors.affiliation: Unité d'hypertension artérielle, Hôpital Européen Georges Pompidou, AP-HP, 20, rue Leblanc, 75015 Paris Paris, France ; Centre d'investigation clinique (CIC 1418), Hôpital Européen Georges Pompidou, AP-HP, Paris, 20, rue Leblanc, 75015 Paris France ; Université Paris-Descartes, Paris, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Amar
authors.affiliation: Unité d'hypertension artérielle, Hôpital Européen Georges Pompidou, AP-HP, 20, rue Leblanc, 75015 Paris Paris, France ; Centre d'investigation clinique (CIC 1418), Hôpital Européen Georges Pompidou, AP-HP, Paris, 20, rue Leblanc, 75015 Paris France ; Université Paris-Descartes, Paris, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Azizi
mesh_terms: D000368:Aged; D057912:Angiotensin II Type 2 Receptor Blockers / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control; D003925:Diabetic Angiopathies; D058065:Diabetic Cardiomyopathies; D005602:France; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009316:National Institutes of Health (U.S.); D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D016896:Treatment Outcome; D014481:United States
chemical_list: D057912:Angiotensin II Type 2 Receptor Blockers; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D001241:Aspirin