title: One Binder to Bind Them All.
abstract: High quality binders, such as antibodies, are of critical importance for chemical sensing applications. With synthetic alternatives, such as molecularly imprinted polymers (MIPs), less sensor development time and higher stability of the binder can be achieved. In this feature paper, I will discuss the impact of synthetic binders from an industrial perspective and I will challenge the molecular imprinting community on the next step to leapfrog the current status quo of MIPs for (bio)sensing. Equally important, but often neglected as an effective chemical sensor, is a good match of transducer and MIP coating for a respective application. To demonstrate an application-driven development, a biosensing use case with surface-imprinted layers on piezoacoustic sensors is reported. Depending on the electrode pattern for the transducer, the strong mechanical coupling of the analyte with the MIP layer coated device allows the adoption of the sensitivity from cell mass to cell viability with complete reversibility.
authors.affiliation: Siemens Healthcare GmbH, Strategy and Innovation, Technology Center, In-Vitro DX & Bioscience, Günther-Scharowsky-Str. 1, 91058 Erlangen, Germany. oliver.hayden@siemens.com.
authors.forename: Oliver
authors.initials: O
authors.lastname: Hayden
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry; D015374:Biosensing Techniques / Q000379:methods*; D004566:Electrodes; D054802:Molecular Imprinting / Q000379:methods*; D011108:Polymers / Q000737:chemistry
chemical_list: D052157:Aptamers, Nucleotide; D011108:Polymers
keywords: aptamers; binder; cells; environment; healthcare; life science; lithography; molecularly imprinted polymers; quartz crystal microbalance; receptor; sensor