title: Consistent quantitative gene product expression: #3. Invariance with age.
abstract: The quantitative expression of cell surface antigens and light scattering properties of five cellular reference populations in stressed bone marrow specimens were compared between pediatric and adult patients treated for acute myeloid leukemia (AML). The mean intensity of each antigen as well as the within patient and between patient variability showed striking consistency between the two different age groups. The only difference between the groups of specimens was the proportion of progenitor cells in the adult cohort averaged less than three times the proportion in the pediatric cohort. These data show that the amounts of gene products expressed on bone marrow cells are invariant with age. © 2016 The Authors. Cytometry Part A Published by Wiley Periodicals, Inc. on behalf of ISAC.
authors.affiliation: HematoLogics, Inc, Seattle, Washington.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Loken
authors.affiliation: HematoLogics, Inc, Seattle, Washington.
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Voigt
authors.affiliation: HematoLogics, Inc, Seattle, Washington.
authors.forename: Lisa
authors.initials: L
authors.lastname: Eidenschink Brodersen
authors.affiliation: HematoLogics, Inc, Seattle, Washington.
authors.forename: Wayne
authors.initials: W
authors.lastname: Fritschle
authors.affiliation: HematoLogics, Inc, Seattle, Washington.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Menssen
authors.affiliation: HematoLogics, Inc, Seattle, Washington.
authors.forename: Denise A
authors.initials: DA
authors.lastname: Wells
mesh_terms: D000328:Adult; D000368:Aged; D005434:Flow Cytometry; D006412:Hematopoietic Stem Cells / Q000145:classification*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*; D008875:Middle Aged; D060388:Support Vector Machine; D059467:Transcriptome
keywords: adult; bone marrow aspirates; flow cytometry; quantitative antigen expression; support vector machines