title: Adult Brain Tumors: Clinical Applications of Magnetic Resonance Spectroscopy.
abstract: Proton magnetic resonance spectroscopy (H-MRS) may be helpful in suggesting tumor histology and tumor grade and may better define tumor extension and the ideal site for biopsy compared with conventional magnetic resonance (MR) imaging. A multifunctional approach with diffusion-weighted imaging, perfusion-weighted imaging, and permeability maps, along with H-MRS, may enhance the accuracy of the diagnosis and characterization of brain tumors and estimation of therapeutic response. Integration of advanced imaging techniques with conventional MR imaging and the clinical history help to improve the accuracy, sensitivity, and specificity in differentiating tumors and nonneoplastic lesions.
authors.affiliation: Clínica Felippe Mattoso, Av. Das Américas 700, sala 320, Barra da Tijuca, Rio de Janeiro 30112011, Brazil; Clínica IRM- Ressonância Magnética, Rua Capitão Salomão 44 Humaitá, Rio de Janeiro 22271040, Brazil. Electronic address: larabrandao.rad@terra.com.br.
authors.forename: Lara A
authors.initials: LA
authors.lastname: Brandão
authors.affiliation: Division of Neuroradiology, Department of Radiology, University of North Carolina School of Medicine, Room 3326, Old Infirmary Building, Manning Drive, Chapel Hill, NC 27599-7510, USA.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Castillo
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D006801:Humans; D008875:Middle Aged; D066244:Proton Magnetic Resonance Spectroscopy / Q000379:methods*; D012680:Sensitivity and Specificity; D055815:Young Adult
keywords: Adult brain tumors; Differential diagnosis; Proton magnetic resonance spectroscopy (H-MRS); Therapeutic response; Tumor extension; Tumor grade; Tumor histology; Tumor progression