title: Comparative evaluation of anti-obesity effect ofAloe veraandGymnema sylvestresupplementation in high-fat diet fed C57BL/6J mice.
abstract: BACKGROUND
  The aim of the present study was to investigate, anti-obesity effect ofAloe vera(AV), andGymnema sylvestre(GS) whole extract powders administration to high-fat diet (HFD) fed C57BL/6J mice for 12 weeks.
  
  
  METHODS
  At the end of experiment, different parameters such as body weight, feed intake, organ weights, fasting blood glucose, oral glucose tolerance test, plasma lipid levels, and expression analysis of adipocytokines were evaluated.
  
  
  RESULTS
  At the end of experimental period, oral administration of both herbs showed a significant (P< 0.05 andP< 0.001) decrease in the plasma glucose and lipid levels in HFD fed mice. In addition, increased in the epididymal fat (E. fat) weight in the HFD group was significantly (P< 0.05) reduced on GS administration alone. Finally, quantitative mRNA expression analysis of adiponectin gene was significantly up-regulated in AV supplementation. Further, no effect was observed with the both herbs on pro-inflammatory cytokines (interleukin 6 and tumor necrosis factor-a) in the E. fat tissue of HFD fed group.
  
  
  CONCLUSIONS
  The anti-obesity and other metabolic studies depend on the type of diet, different parts of herbal extractions, and animal models used. Further studies are required in this area to strengthen the anti-obesity effects of herbs with active component, and it can be used a pro-drug instead of whole extract.
authors.affiliation: Department of Animal Biochemistry, NDRI, Karnal, Haryana, India.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Pothuraju
authors.affiliation: Department of Animal Biochemistry, NDRI, Karnal, Haryana, India.
authors.forename: Raj Kumar
authors.initials: RK
authors.lastname: Sharma
authors.affiliation: Department of Animal Biochemistry, NDRI, Karnal, Haryana, India.
authors.forename: Sarver Ahmed
authors.initials: SA
authors.lastname: Rather
authors.affiliation: Department of Animal Biochemistry, NDRI, Karnal, Haryana, India.
authors.forename: Satvinder
authors.initials: S
authors.lastname: Singh
keywords: Aloe vera; Gymnema sylvestre; high-fat diet; inflammatory markers; obesity