title: Changes in endolymphatic hydrops visualized by magnetic resonance imaging after sac surgery.
abstract: The purpose of the study was to observe changes in endolymphatic hydrops by using intratympanic injection of gadolinium and magnetic resonance imaging (MRI) before and after endolymphatic sac surgery in patients with unilateral Meniere's disease. Thirteen patients with unilateral Meniere's disease undergoing endolymphatic sac surgery were retrospectively and prospectively analyzed. Three-dimensional fluid-attenuated inversion recovery or three-dimensional real inversion recovery MRI was performed 24 h after an intratympanic injection of gadolinium to grade the presence of endolymphatic hydrops. Among the 13 patients with hydrops confirmed by preoperative MRI, vestibular hydrops had no significant change in all patients; cochlear hydrops became negative in 2 patients, and remained unchanged in the other 11 patients after surgery. Definite vertigo attacks were substantially controlled in one patient and completely controlled in 12 patients during a follow-up period of 8-34 months after surgery. The hearing levels were improved in 3 patients, remained unchanged in 7 patients, and decreased in 3 patients. In conclusion, endolymphatic sac surgery does not always alleviate endolymphatic hydrops in patients with Meniere's disease. Relief from vertigo cannot always be attributed to the remission of hydrops. A change in hearing levels cannot be explained by hydrops status alone.
authors.affiliation: Department of Otolaryngology & Head and Neck Surgery, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Otolaryngology & Head and Neck Surgery, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors.forename: Yong-Hua
authors.initials: YH
authors.lastname: Cui
authors.affiliation: Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Otolaryngology & Head and Neck Surgery, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors.forename: Zhong-Yao
authors.initials: ZY
authors.lastname: Mao
authors.affiliation: Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors.forename: Qiu-Xia
authors.initials: QX
authors.lastname: Wang
authors.affiliation: Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors.forename: Chu
authors.initials: C
authors.lastname: Pan
authors.affiliation: Department of Otolaryngology & Head and Neck Surgery, Huazhong University of Science and Technology, Wuhan, 430030, China. aiguoliu309@163.com.
authors.forename: Ai-Guo
authors.initials: AG
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media / Q000008:administration & dosage; D018159:Endolymphatic Hydrops / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D004712:Endolymphatic Sac / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D005260:Female; D005682:Gadolinium / Q000008:administration & dosage; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008575:Meniere Disease / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged
chemical_list: D003287:Contrast Media; D005682:Gadolinium
keywords: Meniere’s disease; endolymphatic hydrops; endolymphatic sac surgery; magnetic resonance imaging