title: Role of lifestyle modifications for patients with laryngeal granuloma caused by gastro-esophageal reflux: comparison between conservative treatment and the surgical approach.
abstract: CONCLUSIONS
  It is considered that a regimen combining pharmacologic management and lifestyle modifications is the most effective treatment for laryngeal granulomas caused by GER.
  
  
  OBJECTIVE
  This study compared the results of the combination therapy and surgery to determine the best treatment of laryngeal granuloma caused by gastro-esophageal reflux in 51 patients.
  
  
  METHODS
  Prospective study.
  
  
  RESULTS
  In the conservative treatment group, the CR rate was 89.7% and recurrence rate was 2.6%, while the lesions remained in patients (7.7%). This study compared the CR and recurrence rates between conservative treatment and surgery for granuloma. The results showed that the laryngeal granuloma recurrence rate was significantly lower with the conservative treatment regimen compared with surgery (p = .0016).
authors.affiliation: a Department of Artificial Organs and Medical Creation, and Otolaryngology , National Hospital Organization, Tokyo Medical Center , Tokyo , Japan.
authors.forename: Rika
authors.initials: R
authors.lastname: Kobayashi
authors.affiliation: a Department of Artificial Organs and Medical Creation, and Otolaryngology , National Hospital Organization, Tokyo Medical Center , Tokyo , Japan.|b Department of Otolaryngology , University of Tokyo , Tokyo , Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Tsunoda
authors.affiliation: a Department of Artificial Organs and Medical Creation, and Otolaryngology , National Hospital Organization, Tokyo Medical Center , Tokyo , Japan.|b Department of Otolaryngology , University of Tokyo , Tokyo , Japan.
authors.forename: Rumi
authors.initials: R
authors.lastname: Ueha
authors.affiliation: a Department of Artificial Organs and Medical Creation, and Otolaryngology , National Hospital Organization, Tokyo Medical Center , Tokyo , Japan.|b Department of Otolaryngology , University of Tokyo , Tokyo , Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Fujimaki
authors.affiliation: a Department of Artificial Organs and Medical Creation, and Otolaryngology , National Hospital Organization, Tokyo Medical Center , Tokyo , Japan.|b Department of Otolaryngology , University of Tokyo , Tokyo , Japan.
authors.forename: Takaharu
authors.initials: T
authors.lastname: Nito
authors.affiliation: a Department of Artificial Organs and Medical Creation, and Otolaryngology , National Hospital Organization, Tokyo Medical Center , Tokyo , Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Yamasoba
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000072700:Conservative Treatment / Q000706:statistics & numerical data*; D005764:Gastroesophageal Reflux / Q000150:complications*; D006102:Granuloma, Laryngeal / Q000188:drug therapy / Q000209:etiology / Q000601:surgery*; D006801:Humans; D008019:Life Style; D008875:Middle Aged; D011446:Prospective Studies; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D054328:Proton Pump Inhibitors
keywords: Laryngeal granuloma; conservative treatment regimen; gastro-esophageal reflux; lifestyle modifications; pharmacologic management; prospective study; recurrence rate; surgery