title: Transition metal-free N-arylation of secondary amides through iodonium salts as aryne precursors.
abstract: By using a diaryliodonium salt as a benzyne precursor, a transition metal-free approach for N-arylation of secondary amides is developed. This novel benzyne precursor, which can be prepared easily by a one step process from an aryl iodide, shows different reactivities with previous benzyne precursors in the N-arylation reaction. Mechanistic studies confirm the involvement of benzyne species (generated in situ from the diaryliodonium salts) as key intermediates.
authors.affiliation: School of Chemistry and Molecular Engineering, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, P. R. China. wangming@chem.ecnu.edu.cn.
authors.forename: Ming
authors.initials: M
authors.lastname: Wang
authors.affiliation: School of Chemistry and Molecular Engineering, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, P. R. China. wangming@chem.ecnu.edu.cn.
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Huang