title: Management of patients with colorectal liver metastasis in eleven questions and answers.
abstract: Colorectal liver metastasis (CRLM) is the most frequent indication for liver resection in many centers. Recent improvements in oncology, surgery, interventional radiology, pathology and anesthesiology allow curative treatment in a larger proportion of patients with CRLM. Areas covered: We illustrate the various aspects of the management of CRLM through 11 questions that summarize the topic, from the current obtained survival to future perspectives such as transplantation. The limits of a curative treatment are also presented from different angles, such as the benefits of pathology, the surgical options for extreme resections, the available chemotherapies and their efficacy, or the non-surgical ablative treatments. Expert commentary: Given the increasing therapeutic possibilities, we strengthen the importance to analyze the situation of each patient with CRLM in a dedicated multidisciplinary team, in order to offer the best individualized treatment combination.
authors.affiliation: a Faculty of Medicine, Hepato-Pancreato-Biliary Centre , Geneva University Hospital , Geneva , Switzerland.|b Faculty of Medicine, Division of Abdominal Surgery , Geneva University Hospital , Geneva , Switzerland.
authors.forename: Axel
authors.initials: A
authors.lastname: Andres
authors.affiliation: a Faculty of Medicine, Hepato-Pancreato-Biliary Centre , Geneva University Hospital , Geneva , Switzerland.|b Faculty of Medicine, Division of Abdominal Surgery , Geneva University Hospital , Geneva , Switzerland.
authors.forename: Pietro
authors.initials: P
authors.lastname: Majno
authors.affiliation: a Faculty of Medicine, Hepato-Pancreato-Biliary Centre , Geneva University Hospital , Geneva , Switzerland.|c Faculty of Medicine, Division of Radiology , Geneva University Hospital , Geneva , Switzerland.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Terraz
authors.affiliation: a Faculty of Medicine, Hepato-Pancreato-Biliary Centre , Geneva University Hospital , Geneva , Switzerland.|b Faculty of Medicine, Division of Abdominal Surgery , Geneva University Hospital , Geneva , Switzerland.
authors.forename: Philippe
authors.initials: P
authors.lastname: Morel
authors.affiliation: a Faculty of Medicine, Hepato-Pancreato-Biliary Centre , Geneva University Hospital , Geneva , Switzerland.|d Faculty of Medicine, Division of Oncology , Geneva University Hospital , Geneva , Switzerland.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Roth
authors.affiliation: a Faculty of Medicine, Hepato-Pancreato-Biliary Centre , Geneva University Hospital , Geneva , Switzerland.|e Faculty of Medicine, Division of Clinical Pathology , Geneva University Hospital , Geneva , Switzerland.
authors.forename: Laura
authors.initials: L
authors.lastname: Rubbia-Brandt
authors.affiliation: a Faculty of Medicine, Hepato-Pancreato-Biliary Centre , Geneva University Hospital , Geneva , Switzerland.|f Faculty of Medicine, Division of Anesthesiology , Geneva University Hospital , Geneva , Switzerland.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Schiffer
authors.affiliation: b Faculty of Medicine, Division of Abdominal Surgery , Geneva University Hospital , Geneva , Switzerland.
authors.forename: Frederic
authors.initials: F
authors.lastname: Ris
authors.affiliation: a Faculty of Medicine, Hepato-Pancreato-Biliary Centre , Geneva University Hospital , Geneva , Switzerland.|b Faculty of Medicine, Division of Abdominal Surgery , Geneva University Hospital , Geneva , Switzerland.
authors.forename: Christian
authors.initials: C
authors.lastname: Toso
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000473:pathology*; D006498:Hepatectomy / Q000379:methods; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D016031:Liver Transplantation / Q000379:methods; D010348:Patient Care Team / Q000458:organization & administration; D057285:Precision Medicine / Q000379:methods*; D015996:Survival Rate
chemical_list: D000970:Antineoplastic Agents
keywords: Colorectal liver metastases; liver cancer; liver locoregional treatment; liver surgery; liver transplantation