title: Total Synthesis of Nannocystin A.
abstract: Nannocystin A is a 21-membered cyclodepsipeptide showing remarkable anticancer properties. Described is the total synthesis of nannocystin A, which features an asymmetric vinylogous Mukaiyama aldol reaction for efficient assembly of the penultimate open-chain precursor and a pivotal intramolecular Heck cross-coupling for the final macrocyclization.
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University , Tianjin 300353, P. R. China.|College of Chemistry and Chemical Engineering, Anyang Normal University , Anyang 455000, P. R. China.
authors.forename: Zhantao
authors.initials: Z
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University , Tianjin 300353, P. R. China.
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University , Tianjin 300353, P. R. China.|College of Chemistry and Chemical Engineering, Anyang Normal University , Anyang 455000, P. R. China.
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University , Tianjin 300353, P. R. China.
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Tian
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University , Tianjin 300353, P. R. China.
authors.forename: Xinyi
authors.initials: X
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University , Tianjin 300353, P. R. China.
authors.forename: Lihui
authors.initials: L
authors.lastname: Lian
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University , Tianjin 300353, P. R. China.
authors.forename: Wenwei
authors.initials: W
authors.lastname: Pan
authors.affiliation: State Key Laboratory of Elemento-organic Chemistry, Nankai University , Tianjin 300071, P. R. China.
authors.forename: Xuncheng
authors.initials: X
authors.lastname: Su
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University , Tianjin 300353, P. R. China.
authors.forename: Weicheng
authors.initials: W
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University , Tianjin 300353, P. R. China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Chen
mesh_terms: D003500:Cyclization; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation
chemical_list: D047028:Macrocyclic Compounds; C000607748:nannocystin A