title: Nintedanib (OFEV) in the treatment of idiopathic pulmonary fibrosis.
abstract: Nintedanib is a new anti-fibrosis agent that is an intracellular tyrosine kinase inhibitor targeting platelet derived growth factor receptor, fibroblast growth factor receptor and vascular endothelial growth factor receptor. Although nintedanib is attracting much attention as a new treatment option for patients with idiopathic pulmonary fibrosis (IPF), the clinical evidence is limited mainly to the results from the dose-deciding phase II TOMORROW trial and phase III INPULSIS trials, which evaluated efficacy and safety of nintedanib for patients with IPF, prespecified subgroup analyses, pooled analyses and meta-analyses derived from those trials. Areas covered: In this document, we mainly reviewed reports on working mechanisms of nintedanib, and efficacy and safety of nintedanib for patients with IPF. The literature search was undertaken using Pub Med. Expert commentary: It is unknown whether the efficacy of nintedanib in patients enrolled in the clinical trials will be the same for the entire spectrum of patients, including patients unfit for the clinical trials due to age, severity, timing of IPF diagnosis or diagnosis of interstitial pneumonias other than IPF. Sufficient consideration should be given when selecting candidates for nintedanib in the real world.
authors.affiliation: a Department of Respiratory Medicine and Allergy , Tosei General Hospital , Seto , Aichi , Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Fukihara
authors.affiliation: a Department of Respiratory Medicine and Allergy , Tosei General Hospital , Seto , Aichi , Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kondoh
mesh_terms: D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000188:drug therapy*; D007211:Indoles / Q000627:therapeutic use*; D017479:Receptors, Platelet-Derived Growth Factor / Q000037:antagonists & inhibitors; D042461:Vascular Endothelial Growth Factor A
chemical_list: D004791:Enzyme Inhibitors; D007211:Indoles; D042461:Vascular Endothelial Growth Factor A; C099852:PDGF receptor tyrosine kinase; D017479:Receptors, Platelet-Derived Growth Factor; C530716:nintedanib
keywords: INPULSIS; IPF; Nintedanib; TOMORROW; idiopathic pulmonary fibrosis; interstitial lung disease