title: Reproductive toxicity induced by nickel nanoparticles in Caenorhabditis elegans.
abstract: To investigate the reproductive toxicity and underlying mechanism of nickel nanoparticles (Ni NPs), Caenorhabditis elegans (C. elegans) were treated with/without 1.0, 2.5, and 5.0 μg cm-2of Ni NPs or nickel microparticles (Ni MPs). Generation time, fertilized egg numbers, spermatide activation and motility were detected. Results indicated, under the same treatment doses, that Ni NPs induced higher reproductive toxicity to C. elegans than Ni MPs. Reproductive toxicities observed in C. elegans included a decrease in brood size, fertilized egg and spermatide activation, but an increase in generation time and out-of-round spermatids. The reproductive toxicity of Ni NPs on C. elegans may be induced by oxidative stress. The reproductive toxicity in C. elegans induced by Ni NPs is consistent with our previous results in the rats. Therefore, C. elegans can be used as an alternative model to detect the early reproductive toxicity of Ni NPs exposure. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1530-1538, 2017.
authors.affiliation: Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing, People's Republic of China, 210009.
authors.forename: Lu
authors.initials: L
authors.lastname: Kong
authors.affiliation: Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing, People's Republic of China, 210009.
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Gao
authors.affiliation: Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing, People's Republic of China, 210009.
authors.forename: Jiaqian
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing, People's Republic of China, 210009.
authors.forename: Ting
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing, People's Republic of China, 210009.
authors.forename: Yuying
authors.initials: Y
authors.lastname: Xue
authors.affiliation: Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing, People's Republic of China, 210009.
authors.forename: Meng
authors.initials: M
authors.lastname: Tang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D017173:Caenorhabditis elegans / Q000187:drug effects* / Q000502:physiology*; D005240:Feasibility Studies; D005260:Female; D005306:Fertilization / Q000187:drug effects*; D008297:Male; D053768:Metal Nanoparticles / Q000633:toxicity*; D008962:Models, Theoretical; D009532:Nickel / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects; D012098:Reproduction / Q000187:drug effects; D013081:Sperm Motility / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*; D018675:Toxicity Tests
chemical_list: D009532:Nickel
keywords: Caenorhabditis elegan; alternative model; nickel nanoparticles; reproductive toxicity