title: Carthorquinosides A and B, Quinochalcone C-Glycosides with Diverse Dimeric Skeletons from Carthamus tinctorius.
abstract: Two novel quinochalcone C-glycosides, carthorquinosides A (1) and B (2), were isolated from the florets of Carthamus tinctorius. Their structures, including the absolute configurations, were established by analysis of NMR and MS data, together with chemical degradation and electronic circular dichroism spectra. Compound 1 has an unprecedented quinochalcone-flavonol structure linked via a methylene bridge, and compound 2 comprises two glucopyranosylquinochalcone moieties linked via the formyl carbon of an acyclic glucosyl unit. A potential biosynthesis pathway is also proposed. Compounds 1 and 2 exhibited anti-inflammatory activities in LPS-stimulated HUVEC cells by regulating IL-1, IL-6, IL-10, and IFN-γ mRNA expression at concentrations as low as 4 μM, and compound 2 also showed inhibitory activity against topoisomerase I at100 μM.
authors.affiliation: Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization and Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine , Nanjing 210023, People's Republic of China.
authors.forename: Shi-Jun
authors.initials: SJ
authors.lastname: Yue
authors.affiliation: Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization and Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine , Nanjing 210023, People's Republic of China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Qu
authors.affiliation: Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization and Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine , Nanjing 210023, People's Republic of China.
authors.forename: Peng-Xuan
authors.initials: PX
authors.lastname: Zhang
authors.affiliation: Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization and Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine , Nanjing 210023, People's Republic of China.
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Tang
authors.affiliation: Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization and Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine , Nanjing 210023, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Jin
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing 100050, People's Republic of China.
authors.forename: Jian-Shuang
authors.initials: JS
authors.lastname: Jiang
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing 100050, People's Republic of China.
authors.forename: Ya-Nan
authors.initials: YN
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing 100050, People's Republic of China.
authors.forename: Pei-Cheng
authors.initials: PC
authors.lastname: Zhang
authors.affiliation: Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization and Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine , Nanjing 210023, People's Republic of China.
authors.forename: Jin-Ao
authors.initials: JA
authors.lastname: Duan
mesh_terms: D000893:Anti-Inflammatory Agents / Q000032:analysis; D031187:Carthamus tinctorius / Q000737:chemistry*; D002599:Chalcone / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D044948:Flavonols / Q000737:chemistry*; D035264:Flowers / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D016753:Interleukin-10 / Q000032:analysis; D015850:Interleukin-6 / Q000032:analysis; D020014:K562 Cells; D015394:Molecular Structure; D009005:Monosaccharides / Q000737:chemistry; D019906:Nuclear Magnetic Resonance, Biomolecular; D017239:Paclitaxel / Q000494:pharmacology; D013329:Structure-Activity Relationship; D059004:Topoisomerase I Inhibitors / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; C438934:C-glycoside; D004365:Drugs, Chinese Herbal; D044948:Flavonols; D006027:Glycosides; C508609:IL10 protein, human; D015850:Interleukin-6; D009005:Monosaccharides; D059004:Topoisomerase I Inhibitors; C000620406:carthorquinoside A; C000620407:carthorquinoside B; D016753:Interleukin-10; D002599:Chalcone; D017239:Paclitaxel