title: C-H activation reactions as useful tools for medicinal chemists.
abstract: In recent years, there has been an exponential rise in the number of reports describing synthetic methods that utilize catalytic sp3and sp2C-H bond activation. Many have emerged as powerful synthetic tools for accessing biologically active motifs. Indeed, application to C-C and C-heteroatom bond formation, provides new directives for the construction of new pharmaceutical entities. Herein, we highlight some recent novel C-H activation processes that exemplify the utility of these transformations in medicinal chemistry.
authors.affiliation: Medicinal Chemistry, Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92102, USA.
authors.forename: Eduardo J E
authors.initials: EJE
authors.lastname: Caro-Diaz
authors.affiliation: Medicinal Chemistry, Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92102, USA.
authors.forename: Mariangela
authors.initials: M
authors.lastname: Urbano
authors.affiliation: Medicinal Chemistry, Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92102, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Buzard
authors.affiliation: Medicinal Chemistry, Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92102, USA.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Jones
mesh_terms: D002384:Catalysis; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D055808:Drug Discovery / Q000379:methods*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis* / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D006571:Heterocyclic Compounds; D006841:Hydrocarbons, Aromatic; D004364:Pharmaceutical Preparations
keywords: C–H activation; Drug discovery; Heterocycles; Medicinal chemistry; Pharmaceuticals