title: Pannexin1 as mediator of inflammation and cell death.
abstract: Pannexins form channels at the plasma membrane surface that establish a pathway for communication between the cytosol of individual cells and their extracellular environment. By doing so, pannexin signaling dictates several physiological functions, but equally underlies a number of pathological processes. Indeed, pannexin channels drive inflammation by assisting in the activation of inflammasomes, the release of pro-inflammatory cytokines, and the activation and migration of leukocytes. Furthermore, these cellular pores facilitate cell death, including apoptosis, pyroptosis and autophagy. The present paper reviews the roles of pannexin channels in inflammation and cell death. In a first part, a state-of-the-art overview of pannexin channel structure, regulation and function is provided. In a second part, the mechanisms behind their involvement in inflammation and cell death are discussed.
authors.affiliation: Department of In Vitro Toxicology and Dermato-Cosmetology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium.
authors.forename: Sara
authors.initials: S
authors.lastname: Crespo Yanguas
authors.affiliation: Department of In Vitro Toxicology and Dermato-Cosmetology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium.
authors.forename: Joost
authors.initials: J
authors.lastname: Willebrords
authors.affiliation: College of Medical, Veterinary and Life Sciences, British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom.
authors.forename: Scott R
authors.initials: SR
authors.lastname: Johnstone
authors.affiliation: Department of In Vitro Toxicology and Dermato-Cosmetology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium.
authors.forename: Michaël
authors.initials: M
authors.lastname: Maes
authors.affiliation: Department of Basic Medical Sciences, Physiology group, Ghent University, Gent, Belgium.
authors.forename: Elke
authors.initials: E
authors.lastname: Decrock
authors.affiliation: Department of Basic Medical Sciences, Physiology group, Ghent University, Gent, Belgium.
authors.forename: Marijke
authors.initials: M
authors.lastname: De Bock
authors.affiliation: Department of Basic Medical Sciences, Physiology group, Ghent University, Gent, Belgium.
authors.forename: Luc
authors.initials: L
authors.lastname: Leybaert
authors.affiliation: Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.
authors.forename: Bruno
authors.initials: B
authors.lastname: Cogliati
authors.affiliation: Department of In Vitro Toxicology and Dermato-Cosmetology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address: mvinken@vub.ac.be.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Vinken
mesh_terms: D000818:Animals; D016923:Cell Death / Q000235:genetics / Q000276:immunology; D002462:Cell Membrane / Q000276:immunology / Q000378:metabolism; D002465:Cell Movement; D017630:Connexins / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology; D003600:Cytosol / Q000276:immunology / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D058847:Inflammasomes / Q000276:immunology* / Q000378:metabolism; D007249:Inflammation / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D007962:Leukocytes / Q000276:immunology* / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D015398:Signal Transduction
chemical_list: D017630:Connexins; D016207:Cytokines; D058847:Inflammasomes; D009419:Nerve Tissue Proteins; C492764:PANX1 protein, human
keywords: Apoptosis; Autophagy; Inflammation; Pannexin; Pyroptosis