title: Pathological and immunological characteristics of piglets infected experimentally with a HP-PRRSV TJ strain.
abstract: BACKGROUND
  Porcine reproductive and respiratory syndrome (PRRS) remains a major threat to swine industry all over the world. The aim of this study was to investigate the mechanism of pathogenesis and immune responses caused by a highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV).
  
  
  RESULTS
  All piglets experimentally infected with a HP-PRRSV TJ strain virus developed typical clinical signs of PRRS. The percentages of CD3+, CD4+, and CD8+lymphocytes significantly decreased in the infected group as compared to the uninfected control animals (p < 0.01). Total WBC dropped in the infected animals during the experiment. The level of ELISA antibody against PRRSV increased in 7-10 days after infection and then started to decline. Pathological observations demonstrated various degree lesions, bleeding and necrosis in the lungs of the infected piglets.
  
  
  CONCLUSIONS
  These results clearly indicated that HP-PRRSV TJ strain infection would activate host humoral immune response at the early period post infection and cause severe pathological damages on lungs and inhibit cellular immune response after infection.
authors.affiliation: Sinovet (Beijing) Biotechnology Co., Ltd., Kaituo Road 5, Haidian District, Beijing, 100085, China.|State Key Laboratory of Special Economic Animal Molecular Biology, Institute of Special Economic Animal and Plant Sciences, Chinese Academy of Agricultural Sciences,, Juye Street 4899, Changchun, Jilin, 130122, China.
authors.forename: Zhenguang
authors.initials: Z
authors.lastname: Li
authors.affiliation: Sinovet (Beijing) Biotechnology Co., Ltd., Kaituo Road 5, Haidian District, Beijing, 100085, China.
authors.forename: Yanliang
authors.initials: Y
authors.lastname: He
authors.affiliation: Jiangyan Animal Health Inspection Institute, Jiangguan Road 251, Taizhou, Jiangsu, 225529, China.
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Special Economic Animal Molecular Biology, Institute of Special Economic Animal and Plant Sciences, Chinese Academy of Agricultural Sciences,, Juye Street 4899, Changchun, Jilin, 130122, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Leng
authors.affiliation: Sinovet (Beijing) Biotechnology Co., Ltd., Kaituo Road 5, Haidian District, Beijing, 100085, China.
authors.forename: Shufen
authors.initials: S
authors.lastname: Li
authors.affiliation: State Key Laboratory of Special Economic Animal Molecular Biology, Institute of Special Economic Animal and Plant Sciences, Chinese Academy of Agricultural Sciences,, Juye Street 4899, Changchun, Jilin, 130122, China.
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Wen
authors.affiliation: State Key Laboratory of Special Economic Animal Molecular Biology, Institute of Special Economic Animal and Plant Sciences, Chinese Academy of Agricultural Sciences,, Juye Street 4899, Changchun, Jilin, 130122, China.
authors.forename: Fengxue
authors.initials: F
authors.lastname: Wang
authors.affiliation: Sinovet (Beijing) Biotechnology Co., Ltd., Kaituo Road 5, Haidian District, Beijing, 100085, China.
authors.forename: Mingqi
authors.initials: M
authors.lastname: Xia
authors.affiliation: State Key Laboratory of Special Economic Animal Molecular Biology, Institute of Special Economic Animal and Plant Sciences, Chinese Academy of Agricultural Sciences,, Juye Street 4899, Changchun, Jilin, 130122, China.
authors.forename: Shipeng
authors.initials: S
authors.lastname: Cheng
authors.affiliation: Sinovet (Beijing) Biotechnology Co., Ltd., Kaituo Road 5, Haidian District, Beijing, 100085, China. wuhua@sinovetah.com.|State Key Laboratory of Special Economic Animal Molecular Biology, Institute of Special Economic Animal and Plant Sciences, Chinese Academy of Agricultural Sciences,, Juye Street 4899, Changchun, Jilin, 130122, China. wuhua@sinovetah.com.
authors.forename: Hua
authors.initials: H
authors.lastname: Wu
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D008168:Lung / Q000473:pathology; D008214:Lymphocytes / Q000276:immunology; D019318:Porcine Reproductive and Respiratory Syndrome / Q000276:immunology* / Q000473:pathology* / Q000821:virology; D019316:Porcine respiratory and reproductive syndrome virus / Q000276:immunology; D013552:Swine
chemical_list: D000914:Antibodies, Viral
keywords: HP-PRRSV; cell-mediated immunity; humoral immunity; immune responses