title: [Head and Neck Cancer in Pregnancy - Recommendations for Diagnosis and Therapy With Case Report].
abstract: Objective:The diagnosis of cancer in pregnancy is rare, but might become more relevant even for head and neck cancer patients due to a shift of age of primipara towards the last third of reproductive years. Unsureness exists about the risk and benefit of diagnostic and therapeutic cancer modalities for the unborn and established recommendations are still missing. But, according to recent data, even multimodal therapeutic approaches (e. g. surgery, radiation, chemotherapy) seem possible in face of pregnancy and should be traded against the risk of prematurity.Material and Methods:Our findings are discussed on the basis of a case report of a pregnant woman with advanced carcinoma of the outer ear canal and therapy options are formulated.Results:Sufficient performed diagnostic modalities do not reach imperilling uterus dosages. A growing number of case reports und studies did not detect any developmental disadvantage of children of prenatal exposed mothers by radiation or chemotherapy, whereas long-term impairments of premature infants are proven.Conclusion:In cancer in pregnancy, an immediate start of well-established therapy modalities like surgery and/or cisplatin-based chemoradiation seems to be possible without unjustifiable risks for the unborn.
authors.affiliation: ENT, Schwarzwald-Baar-Klinikum Villingen-Schwenningen, Villingen-Schwenningen.
authors.forename: C
authors.initials: C
authors.lastname: Mozet
authors.affiliation: Bildgebung und Strahlenmedizin, Universitätsklinikum Leipzig, Leipzig.
authors.forename: T
authors.initials: T
authors.lastname: Kuhnt
authors.affiliation: Medizinphysik, Klinik und Poliklinik für Nuklearmedizin Leipzig, Leipzig.
authors.forename: B
authors.initials: B
authors.lastname: Sattler
authors.affiliation: Klinik für Strahlentherapie und Radioonklogie, Universitatsklinikum Leipzig, Leipzig.
authors.forename: J
authors.initials: J
authors.lastname: Remmele
authors.affiliation: Neonatologie, Universität Leipzig, Leipzig.
authors.forename: U
authors.initials: U
authors.lastname: Thome
authors.affiliation: Geburtsmedizin, Universitatsklinikum Leipzig, Leipzig.
authors.forename: H
authors.initials: H
authors.lastname: Stepan
authors.affiliation: Nuklearmedizin, Universitatsklinikum Leipzig, Leipzig.
authors.forename: R
authors.initials: R
authors.lastname: Kluge
authors.affiliation: Plastische Operationen, Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde, Universität Leipzig, Leipzig.
authors.forename: A
authors.initials: A
authors.lastname: Dietz
authors.affiliation: Krebszentrm (UCCL),Universitatsklinikum Leipzig, Leipzig.
authors.forename: M
authors.initials: M
authors.lastname: Knoedler
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D059186:Chemoradiotherapy, Adjuvant / Q000009:adverse effects; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D003131:Combined Modality Therapy / Q000009:adverse effects; D003937:Diagnosis, Differential; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D009367:Neoplasm Staging; D010039:Otorhinolaryngologic Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D010579:Petrous Bone / Q000473:pathology; D000072078:Positron Emission Tomography Computed Tomography; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D011879:Radiotherapy Dosage; D012306:Risk; D014057:Tomography, X-Ray Computed
chemical_list: D002945:Cisplatin