title: Remote Limb Ischemic Conditioning at Two Cuff Inflation Pressures Yields Learning Enhancements in Healthy Adults.
abstract: The authors tested whether 2 doses of remote limb ischemic conditioning (RLIC), induced via blood pressure cuff inflation, enhanced motor and cognitive learning to an equal extent, and explored a panel of blood biomarkers of RLIC. Thirty-two young adults were randomized to 3 groups and underwent a 7-day protocol of RLIC/sham followed by motor and cognitive training, with follow-up. Both RLIC groups had greater motor learning and a trend toward greater cognitive learning compared with the sham group. RLIC at the lower inflation pressure was as effective as RLIC with the higher inflation pressure. No significant candidate blood biomarkers were found. RLIC could be a well-tolerated method to enhance learning and improve rehabilitation outcomes in people with neurological conditions.
authors.affiliation: a Program in Physical Therapy , Washington University School of Medicine , St. Louis , Missouri.
authors.forename: Kendra M
authors.initials: KM
authors.lastname: Cherry-Allen
authors.affiliation: b Department of Neurological Surgery , Washington University School of Medicine , St. Louis , Missouri.|c Department of Cell Biology and Physiology , Washington University School of Medicine , St. Louis , Missouri.|d Department of Ophthalmology and Visual Sciences , Washington University School of Medicine , St. Louis , Missouri.|e Department of Ophthalmology , Louisiana State University School of Medicine , New Orleans.
authors.forename: Jeff M
authors.initials: JM
authors.lastname: Gidday
authors.affiliation: f Department of Neurology , Washington University School of Medicine , St. Louis , Missouri.
authors.forename: Jin-Moo
authors.initials: JM
authors.lastname: Lee
authors.affiliation: f Department of Neurology , Washington University School of Medicine , St. Louis , Missouri.|g Department of Psychiatry , Washington University School of Medicine , St. Louis , Missouri.|h Department of Radiology , Washington University School of Medicine , St. Louis , Missouri.
authors.forename: Tamara
authors.initials: T
authors.lastname: Hershey
authors.affiliation: a Program in Physical Therapy , Washington University School of Medicine , St. Louis , Missouri.|f Department of Neurology , Washington University School of Medicine , St. Louis , Missouri.|i Program in Occupational Therapy , Washington University School of Medicine , St. Louis , Missouri.
authors.forename: Catherine E
authors.initials: CE
authors.lastname: Lang
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D003213:Conditioning, Psychological / Q000502:physiology*; D005121:Extremities / Q000098:blood supply*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007511:Ischemia; D007858:Learning / Q000502:physiology*; D008297:Male; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: behavioral training; human learning; motor learning; remote limb ischemic conditioning