title: Ozone and Other Air Pollutants and the Risk of Congenital Heart Defects.
abstract: The objective of this study was to evaluate whether high levels of maternal exposure to O3, SO2, NO2, CO are related to increased risk of congenital heart defects (CHDs) in Wuhan, China. The study included mothers living in the central districts of Wuhan during pregnancy over the two-year period from June 10, 2011 to June 9, 2013. For each study participant, we assigned 1-month averages of O3, SO2, NO2and CO exposure based on measurements obtained from the nearest exposure monitor to the living residence of mothers during their early pregnancy period. In one-pollutant model, we observed an increased risk of CHDs, ventricular septal defect (VSD), and tetralogy of fallot (TF) with increasing O3exposure. In two-pollutant model, associations with all CHDs, VSD, and TF for O3were generally consistent compared to the models that included only O3, with the strongest aORs observed for exposures during the third month of pregnancy. We also observed a positive association between CO exposures during the third month of pregnancy and VSD in two pollution model.Our results contribute to the small body of evidence regarding air pollution exposure and CHDs, but confirmation of these associations will be needed in future studies.
authors.affiliation: Wuhan Medical &Healthcare Center for Women and Children, Wuhan, Hubei Province 430030, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Wuhan Medical &Healthcare Center for Women and Children, Wuhan, Hubei Province 430030, China.
authors.forename: Jinzhu
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Wuhan Medical &Healthcare Center for Women and Children, Wuhan, Hubei Province 430030, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Yang
authors.affiliation: College for Public Health and Social Justice, Saint Louis University, Saint Louis, MO, USA.
authors.forename: Zhengmin
authors.initials: Z
authors.lastname: Qian
authors.affiliation: Wuhan Environmental Monitoring Center, Wuhan, Hubei Province 430000, China.
authors.forename: Shengwen
authors.initials: S
authors.lastname: Liang
authors.affiliation: Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT 06510, USA.
authors.forename: Bryan A
authors.initials: BA
authors.lastname: Bassig
authors.affiliation: Wuhan Medical &Healthcare Center for Women and Children, Wuhan, Hubei Province 430030, China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Wuhan Environmental Monitoring Center, Wuhan, Hubei Province 430000, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Hu
authors.affiliation: Key Laboratory of Environment and Health, Ministry of Education &Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Shunqing
authors.initials: S
authors.lastname: Xu
authors.affiliation: Department of Environmental Health, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China.
authors.forename: Guanghui
authors.initials: G
authors.lastname: Dong
authors.affiliation: Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA.
authors.forename: Tongzhang
authors.initials: T
authors.lastname: Zheng
authors.affiliation: Wuhan Medical &Healthcare Center for Women and Children, Wuhan, Hubei Province 430030, China.
authors.forename: Shaoping
authors.initials: S
authors.lastname: Yang
mesh_terms: D000328:Adult; D000393:Air Pollutants / Q000009:adverse effects*; D002248:Carbon Monoxide / Q000009:adverse effects / Q000032:analysis; D002681:China / Q000453:epidemiology; D005260:Female; D005865:Gestational Age; D006330:Heart Defects, Congenital / Q000453:epidemiology*; D006801:Humans; D007223:Infant; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects*; D009569:Nitric Oxide / Q000009:adverse effects / Q000032:analysis; D010126:Ozone / Q000009:adverse effects / Q000032:analysis; D011247:Pregnancy; D012306:Risk; D013458:Sulfur Dioxide / Q000009:adverse effects / Q000032:analysis; D055815:Young Adult
chemical_list: D000393:Air Pollutants; D013458:Sulfur Dioxide; D009569:Nitric Oxide; D010126:Ozone; D002248:Carbon Monoxide