title: Unilateral Carotid Body Resection in Resistant Hypertension: A Safety and Feasibility Trial.
abstract: Animal and human data indicate pathological afferent signaling emanating from the carotid body that drives sympathetically mediated elevations in blood pressure in conditions of hypertension. This first-in-man, proof-of-principle study tested the safety and feasibility of unilateral carotid body resection in 15 patients with drug-resistant hypertension. The procedure proved to be safe and feasible. Overall, no change in blood pressure was found. However, 8 patients showed significant reductions in ambulatory blood pressure coinciding with decreases in sympathetic activity. The carotid body may be a novel target for treating an identifiable subpopulation of humans with hypertension.
authors.affiliation: Department of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Narkiewicz
authors.affiliation: CardioNomics Research Group, Clinical Research & Imaging Centre, University of Bristol and University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom.
authors.forename: Laura E K
authors.initials: LE
authors.lastname: Ratcliffe
authors.affiliation: CardioNomics Research Group, Clinical Research & Imaging Centre, University of Bristol and University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom; School of Physiology, Pharmacology & Neuroscience, Biomedical Sciences, University of Bristol, Bristol, United Kingdom.
authors.forename: Emma C
authors.initials: EC
authors.lastname: Hart
authors.affiliation: CardioNomics Research Group, Clinical Research & Imaging Centre, University of Bristol and University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom.
authors.forename: Linford J B
authors.initials: LJ
authors.lastname: Briant
authors.affiliation: Department of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland.
authors.forename: Marzena
authors.initials: M
authors.lastname: Chrostowska
authors.affiliation: Department of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Wolf
authors.affiliation: Department of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Szyndler
authors.affiliation: Department of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland.
authors.forename: Dagmara
authors.initials: D
authors.lastname: Hering
authors.affiliation: School of Physiology, Pharmacology & Neuroscience, Biomedical Sciences, University of Bristol, Bristol, United Kingdom.
authors.forename: Ana P
authors.initials: AP
authors.lastname: Abdala
authors.affiliation: CardioNomics Research Group, Clinical Research & Imaging Centre, University of Bristol and University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom.
authors.forename: Nathan
authors.initials: N
authors.lastname: Manghat
authors.affiliation: CardioNomics Research Group, Clinical Research & Imaging Centre, University of Bristol and University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom.
authors.forename: Amy E
authors.initials: AE
authors.lastname: Burchell
authors.affiliation: CardioNomics Research Group, Clinical Research & Imaging Centre, University of Bristol and University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom.
authors.forename: Claire
authors.initials: C
authors.lastname: Durant
authors.affiliation: NIHR Barts Cardiovascular Biomedical Research Unit, William Harvey Research Institute, QMUL, Charterhouse Square, London, United Kingdom.
authors.forename: Melvin D
authors.initials: MD
authors.lastname: Lobo
authors.affiliation: Department of Internal Medicine, Division of Cardiovascular Diseases, The Ohio State University, Columbus, Ohio.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Sobotka
authors.affiliation: Neurosurgery, North Bristol NHS Trust, Southmead Hospital, Bristol, United Kingdom.
authors.forename: Nikunj K
authors.initials: NK
authors.lastname: Patel
authors.affiliation: Department of Physiology and Neurobiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
authors.forename: James C
authors.initials: JC
authors.lastname: Leiter
authors.affiliation: Cibiem, Los Altos, California.
authors.forename: Zoar J
authors.initials: ZJ
authors.lastname: Engelman
authors.affiliation: CardioNomics Research Group, Clinical Research & Imaging Centre, University of Bristol and University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom.
authors.forename: Angus K
authors.initials: AK
authors.lastname: Nightingale
authors.affiliation: School of Physiology, Pharmacology & Neuroscience, Biomedical Sciences, University of Bristol, Bristol, United Kingdom.
authors.forename: Julian F R
authors.initials: JF
authors.lastname: Paton
keywords: ABP, ambulatory blood pressure; ASBP, ambulatory systolic blood pressure; BRS, baroreceptor reflex sensitivity; CB, carotid body; HRV, heart rate variability; HVR, hypoxic ventilatory response; MSNA, muscle sympathetic nerve activity; OBP, office blood pressure; OSBP, office systolic blood pressure; afferent drive; baroreceptor reflex; hypertension; hypoxia; peripheral chemoreceptor; sympathetic nervous system; uCB, unilateral carotid body