title: The influence of low calcium dialysate on left ventricular diastolic function in peritoneal dialysis patients.
abstract: Left ventricular (LV) diastolic function was found to be a significant predictor of cardiovascular events and general mortality in dialysis. Studies have indicated that dialysate calcium concentrations were significantly associated with cardiac function. However, the relationship between low calcium dialysate and LV diastolic function has not been clear. The aim of this study was to investigate the influence of low calcium dialysate on cardiac function in peritoneal dialysis (PD) patients. A total of 60 PD patients were enrolled in this study, with a calcium content of the PD solution of 1.25 mmol/L in 30 patients (low-calcium group) and 1.75 mmol/L in 30 patients (standard-calcium group). Standard M-mode and two-dimensional ultrasound measurements were applied to detect the cardiac function. After 12-month follow-up, we found no significant difference in blood pressure, calcium, phosphorus, parathyroid hormone (PTH), etc., between the two groups. Residual renal function (RRF), which is associated with LV cardiac function, was significantly decreased in the standard-calcium group compared with the low-calcium group (5.64 ± 3.23 vs. 9.38 ± 3.17, p = .001). Compared with the low-calcium group, Emax(peak early diastolic velocity) and Amax(peak late diastolic velocity) were significantly decreased (p < .05), whereas myocardial performance index (MPI) was obviously increased in standard-calcium group (9.69 ± 2.71 vs. 7.75 ± 0.93, p < .05). In conclusion, our data suggest that low calcium dialysate treatment is significantly associated with better LV diastolic function.
authors.affiliation: a Department of Graduate School, Southern Medical University , Guangzhou , China.|b Division of Nephrology , Guangdong General Hospital, Guangdong Academy of Medical Sciences , Guangzhou , China.|c Department of Nephrology , The Second Affiliated Hospital of Guangzhou Medical University , Guangzhou , China.
authors.forename: Zebin
authors.initials: Z
authors.lastname: Wang
authors.affiliation: c Department of Nephrology , The Second Affiliated Hospital of Guangzhou Medical University , Guangzhou , China.
authors.forename: Yueqiang
authors.initials: Y
authors.lastname: Wen
authors.affiliation: c Department of Nephrology , The Second Affiliated Hospital of Guangzhou Medical University , Guangzhou , China.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Liang
authors.affiliation: b Division of Nephrology , Guangdong General Hospital, Guangdong Academy of Medical Sciences , Guangzhou , China.
authors.forename: Xinling
authors.initials: X
authors.lastname: Liang
authors.affiliation: a Department of Graduate School, Southern Medical University , Guangzhou , China.|b Division of Nephrology , Guangdong General Hospital, Guangdong Academy of Medical Sciences , Guangzhou , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Shi
mesh_terms: D000368:Aged; D002118:Calcium / Q000008:administration & dosage* / Q000097:blood*; D002681:China; D015314:Dialysis Solutions / Q000008:administration & dosage*; D003971:Diastole; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000000981:diagnostic imaging / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects*; D010758:Phosphorus / Q000097:blood; D016277:Ventricular Function, Left / Q000187:drug effects*
chemical_list: D015314:Dialysis Solutions; D010281:Parathyroid Hormone; D010758:Phosphorus; D002118:Calcium
keywords: Low calcium dialysate; cardiovascular disease; diastolic dysfunction; peritoneal dialysis; residual renal function