title: Dietary iron intake and breast cancer risk: modulation by an antioxidant supplementation.
abstract: Experimental results suggested that iron-induced lipid peroxidation may explain the direct associations observed between red/processed meat intakes and colorectal and breast cancer risk. However, epidemiological evidence is lacking. Thus, we investigated the association between dietary iron intake and breast cancer risk, and its potential modulation by an antioxidant supplementation and lipid intake. This prospective study included 4646 women from the SU.VI.MAX trial (daily low-dose antioxidants vs. placebo). 188 incident breast cancers were diagnosed (median follow-up=12.6y). Dietary iron intake was assessed using repeated 24h dietary records. Multivariable Cox proportional hazards models were computed. Dietary iron intake was associated with an increased breast cancer risk (HRT3vs.T1=1.67 (1.02-2.71), P-trend=0.04). This association was observed in the placebo group (HRT3vs.T1=2.80 (1.42-5.54), P-trend=0.003), but not in the antioxidant-supplemented group (P-trend=0.7, P-interaction=0.1). Besides, in the placebo group, the increased breast cancer risk associated with dietary iron intake was more specifically observed in women with higher lipid intake (P-trend=0.046). These findings suggest that dietary iron intake may be associated with an increased breast cancer risk, especially in women who did not received antioxidants during the trial and who consumed more lipids. This supports the experimental results suggesting that breast cancer risk may be increased by iron-induced lipid peroxidation.
authors.affiliation: Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), Inserm U1153, Inra U1125, Cnam, Paris 5, 7 and 13 Universities, Nutritional Epidemiology Research Team (EREN), Bobigny, France.|Public Health Department, Avicenne Hospital, Bobigny, France.|French Network for Nutrition And Cancer Research (NACRe Network), Bobigny, France.
authors.forename: Abou
authors.initials: A
authors.lastname: Diallo
authors.affiliation: Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), Inserm U1153, Inra U1125, Cnam, Paris 5, 7 and 13 Universities, Nutritional Epidemiology Research Team (EREN), Bobigny, France.|French Network for Nutrition And Cancer Research (NACRe Network), Bobigny, France.
authors.forename: Mélanie
authors.initials: M
authors.lastname: Deschasaux
authors.affiliation: Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), Inserm U1153, Inra U1125, Cnam, Paris 5, 7 and 13 Universities, Nutritional Epidemiology Research Team (EREN), Bobigny, France.|French Network for Nutrition And Cancer Research (NACRe Network), Bobigny, France.
authors.forename: Valentin
authors.initials: V
authors.lastname: Partula
authors.affiliation: Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), Inserm U1153, Inra U1125, Cnam, Paris 5, 7 and 13 Universities, Nutritional Epidemiology Research Team (EREN), Bobigny, France.|French Network for Nutrition And Cancer Research (NACRe Network), Bobigny, France.
authors.forename: Paule
authors.initials: P
authors.lastname: Latino-Martel
authors.affiliation: Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), Inserm U1153, Inra U1125, Cnam, Paris 5, 7 and 13 Universities, Nutritional Epidemiology Research Team (EREN), Bobigny, France.|French Network for Nutrition And Cancer Research (NACRe Network), Bobigny, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Srour
authors.affiliation: Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), Inserm U1153, Inra U1125, Cnam, Paris 5, 7 and 13 Universities, Nutritional Epidemiology Research Team (EREN), Bobigny, France.|Public Health Department, Avicenne Hospital, Bobigny, France.|French Network for Nutrition And Cancer Research (NACRe Network), Bobigny, France.
authors.forename: Serge
authors.initials: S
authors.lastname: Hercberg
authors.affiliation: Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), Inserm U1153, Inra U1125, Cnam, Paris 5, 7 and 13 Universities, Nutritional Epidemiology Research Team (EREN), Bobigny, France.|French Network for Nutrition And Cancer Research (NACRe Network), Bobigny, France.
authors.forename: Pilar
authors.initials: P
authors.lastname: Galan
authors.affiliation: Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), Inserm U1153, Inra U1125, Cnam, Paris 5, 7 and 13 Universities, Nutritional Epidemiology Research Team (EREN), Bobigny, France.|French Network for Nutrition And Cancer Research (NACRe Network), Bobigny, France.
authors.forename: Philippine
authors.initials: P
authors.lastname: Fassier
authors.affiliation: French Network for Nutrition And Cancer Research (NACRe Network), Bobigny, France.|UMR 1331 Toxalim, INRA/INP/UPS, Toulouse, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Guéraud
authors.affiliation: French Network for Nutrition And Cancer Research (NACRe Network), Bobigny, France.|UMR 1331 Toxalim, INRA/INP/UPS, Toulouse, France.
authors.forename: Fabrice H
authors.initials: FH
authors.lastname: Pierre
authors.affiliation: Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), Inserm U1153, Inra U1125, Cnam, Paris 5, 7 and 13 Universities, Nutritional Epidemiology Research Team (EREN), Bobigny, France.|French Network for Nutrition And Cancer Research (NACRe Network), Bobigny, France.
authors.forename: Mathilde
authors.initials: M
authors.lastname: Touvier
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000008:administration & dosage*; D001943:Breast Neoplasms / Q000453:epidemiology*; D019587:Dietary Supplements / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007501:Iron / Q000009:adverse effects*; D015227:Lipid Peroxidation; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D000975:Antioxidants; D007501:Iron
keywords: antioxidants; breast cancer; dietary iron; lipid peroxidation; prospective study