title: [Hydroxychloroquine-induced hearing loss: First case of positive rechallenge and analysis of the French pharmacovigilance database].
abstract: BACKGROUND
  Several cases of hearing loss induced by hydroxychloroquine have been reported in the literature but the role of hydroxychloroquine still remains debated.
  
  
  METHODS
  We report the first case, to our knowledge, of hearing loss induced by hydroxychloroquine with a positive re challenge in a woman treated for systemic lupus. An analysis of the French pharmacovigilance database allowed to identify 23 additional cases of hearing loss in patients treated with hydroxychloroquine and, among them, 8 had systemic lupus.
  
  
  CONCLUSIONS
  Despite an excellent tolerance and high efficacy-side effect ratio, this case report adds some evidence for an otoxicity of hydroxychloroquine.
authors.affiliation: Centre régional de pharmacovigilance de Lille, CHRU de Lille, 1, place de Verdun, 59045 Lille cedex, France.
authors.forename: J-N
authors.initials: JN
authors.lastname: Chatelet
authors.affiliation: Centre régional de pharmacovigilance de Lille, CHRU de Lille, 1, place de Verdun, 59045 Lille cedex, France. Electronic address: ma.auffret@gmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Auffret
authors.affiliation: Centre régional de pharmacovigilance de Dijon, CHU de Dijon, 21079 Dijon cedex France.
authors.forename: S
authors.initials: S
authors.lastname: Combret
authors.affiliation: Centre régional de pharmacovigilance de Toulouse, CHU de Toulouse, 31000 Toulouse France.
authors.forename: E
authors.initials: E
authors.lastname: Bondon-Guitton
authors.affiliation: Service de médecine Interne, hôpital Claude-Huriez, CHRU de Lille, 59045 Lille cedex France.
authors.forename: M
authors.initials: M
authors.lastname: Lambert
authors.affiliation: Centre régional de pharmacovigilance de Lille, CHRU de Lille, 1, place de Verdun, 59045 Lille cedex, France.
authors.forename: S
authors.initials: S
authors.lastname: Gautier
mesh_terms: D000328:Adult; D018501:Antirheumatic Agents / Q000009:adverse effects*; D016208:Databases, Factual; D005260:Female; D005602:France; D034381:Hearing Loss / Q000139:chemically induced*; D006801:Humans; D006886:Hydroxychloroquine / Q000009:adverse effects*; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy*; D060735:Pharmacovigilance
chemical_list: D018501:Antirheumatic Agents; D006886:Hydroxychloroquine
keywords: Adverse drug reaction; Effet indésirable; Hearing loss; Hydroxychloroquine; Lupus; Perte d’audition; Surdité