title: Evaluation of D-Dimer in Screening Deep Vein Thrombosis in Hospitalized Japanese Patients with Acute Medical Diseases/Episodes.
abstract: Objective:To investigate the usefulness of D-dimer as a screening method as well as to explore potent predictors of deep vein thrombosis (DVT) in hospitalized Japanese patients with acute medical diseases/episodes.Methods and Subjects:This study was a multi-center, prospective, observational study. The inclusion criteria were hospitalized patients at high risk of developing venous thromboembolism with; (1) congestive heart failure, acute exacerbation of chronic obstructive pulmonary disease, infectious diseases, or inflammatory diseases, (2) bed rest ≥4 days, and (3) ≥60 years old. D-dimer was measured on the same day as ultrasonography. Multivariate logistic regression analysis was performed to investigate predictors associated with the presence of DVT.Results:Sixty-nine patients were enrolled. The prevalence of DVT was 33.3% (23/69; 95% C.I., 19.4% to 47.3%). D-dimer was measured in 42 patients and the sensitivity and negative predictive value reached 100%, while the specificity (13.3%) and positive predictive value (31.6%) were low (cut-off value: 0.9 or 1.0 µg/mL). Statistically significant predictor was not assigned.Conclusion:As the sensitivity and negative predictive value of D-dimer reached 100%, D-dimer have a role in excluding patients who might otherwise undergo diagnostic imaging for DVT in hospitalized Japanese patients with acute medical diseases/episodes.
authors.affiliation: Matsuo Vascular Ultrasound Laboratory, Matsuo Clinic, Suita, Osaka, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsuo
authors.affiliation: Department of Cardiology, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan.
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Nakajima
authors.affiliation: Cardiovascular Disease Center, Fukushima Daiichi Hospital, Fukushima, Fukushima, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Ogawa
authors.affiliation: Department of Cardiovascular Surgery, Yokohama Minami Kyousai Hospital, Yokohama, Kanagawa, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Mo
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Tazaki
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Doi
authors.affiliation: Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
authors.forename: Norikazu
authors.initials: N
authors.lastname: Yamada
authors.affiliation: Development & Medical Affairs Division, GlaxoSmithKline K.K., Shibuya, Tokyo, Japan.
authors.forename: Takeo
authors.initials: T
authors.lastname: Suzuki
authors.affiliation: Development & Medical Affairs Division, GlaxoSmithKline K.K., Shibuya, Tokyo, Japan.
authors.forename: Hiromu
authors.initials: H
authors.lastname: Nakajima
keywords: D-dimer; Japanese patients; deep vein thrombosis; medical patients; predictors