title: Effect of Transmural Extent of the Simulated Infarction in a Left Ventricular Model on Displacement and Strain Distribution Estimated from Synthetic Ultrasonic Data.
abstract: The identification of a sub-endocardial infarction is of major interest in cardiology. This study evaluates the sensitivity of selected measures to the thickness of such an infarction. Synthetic ultrasonic data (long-axis view) of left ventricular models with inclusions were generated using Field II and meshes obtained from finite-element simulations, which also provided the reference for the estimates obtained from ultrasonic data. The displacements, the first and second component of the principal strain (ε1and ε2), and several measures derived from these quantities were estimated. All estimates, except for the poorly estimated ε2, exhibited sensitivity to the presence and transmurality of the inclusion. The most sensitive was the gradient of the averaged transmural profiles of ε1, and ε1averaged over the area corresponding to the transmural inclusion. The inflection point of the ε1profile shifted toward the outer wall with increasing thickness of the non-transmural inclusion.
authors.affiliation: Institute of Metrology and Biomedical Engineering, Warsaw University of Technology, Warsaw, Poland.
authors.forename: Jakub
authors.initials: J
authors.lastname: Żmigrodzki
authors.affiliation: Institute of Metrology and Biomedical Engineering, Warsaw University of Technology, Warsaw, Poland.
authors.forename: Szymon
authors.initials: S
authors.lastname: Cygan
authors.affiliation: Institute of Metrology and Biomedical Engineering, Warsaw University of Technology, Warsaw, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Leśniak-Plewińska
authors.affiliation: Institute of Cardiology, Department of Congenital Cardiac Defects, Warsaw, Poland.
authors.forename: MirosŁaw
authors.initials: M
authors.lastname: Kowalski
authors.affiliation: Institute of Metrology and Biomedical Engineering, Warsaw University of Technology, Warsaw, Poland. Electronic address: k.kaluzynski@mchtr.pw.edu.pl.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: KaŁużyński
mesh_terms: D003198:Computer Simulation; D004452:Echocardiography / Q000379:methods*; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008954:Models, Biological; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000503:physiopathology
keywords: Displacement estimation; Left ventricular model; Principal strain; Strain estimation; Strain gradient; Sub-endocardial infarction; Synthetic ultrasonic data