title: Clinical Value of High Mobility Group Box 1 and the Receptor for Advanced Glycation End-products in Head and Neck Cancer: A Systematic Review.
abstract: IntroductionHigh mobility group box 1 is a versatile protein involved in gene transcription, extracellular signaling, and response to inflammation. Extracellularly, high mobility group box 1 binds to several receptors, notably the receptor for advanced glycation end-products. Expression of high mobility group box 1 and the receptor for advanced glycation end-products has been described in many cancers.ObjectivesTo systematically review the available literature using PubMed and Web of Science to evaluate the clinical value of high mobility group box 1 and the receptor for advanced glycation end-products in head and neck squamous cell carcinomas.Data synthesisA total of eleven studies were included in this review. High mobility group box 1 overexpression is associated with poor prognosis and many clinical and pathological characteristics of head and neck squamous cell carcinomas patients. Additionally, the receptor for advanced glycation end-products demonstrates potential value as a clinical indicator of tumor angiogenesis and advanced staging. In diagnosis, high mobility group box 1 demonstrates low sensitivity.ConclusionHigh mobility group box 1 and the receptor for advanced glycation end-products are associated with clinical and pathological characteristics of head and neck squamous cell carcinomas. Further investigation of the prognostic and diagnostic value of these molecules is warranted.
authors.affiliation: Department of Clinical and Translational Science, Creighton University School of Medicine, Omaha, Nebraska, United States.
authors.forename: Austin
authors.initials: A
authors.lastname: Nguyen
authors.affiliation: Department of Clinical and Translational Science, Creighton University School of Medicine, Omaha, Nebraska, United States.
authors.forename: Sheila
authors.initials: S
authors.lastname: Bhavsar
authors.affiliation: Department of Clinical and Translational Science, Creighton University School of Medicine, Omaha, Nebraska, United States.
authors.forename: Erinn
authors.initials: E
authors.lastname: Riley
authors.affiliation: Department of Pathology, Creighton University School of Medicine, Omaha, Nebraska, United States.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Caponetti
authors.affiliation: Department of Clinical and Translational Science, Creighton University School of Medicine, Omaha, Nebraska, United States.
authors.forename: Devendra
authors.initials: D
authors.lastname: Agrawal
keywords: HMGB1 protein; advanced glycosylation end product-specific receptor; head and neck neoplasms