title: 3D mapping of elastic modulus using shear wave optical micro-elastography.
abstract: Elastography provides a powerful tool for histopathological identification and clinical diagnosis based on information from tissue stiffness. Benefiting from high resolution, three-dimensional (3D), and noninvasive optical coherence tomography (OCT), optical micro-elastography has the ability to determine elastic properties with a resolution of ~10 μm in a 3D specimen. The shear wave velocity measurement can be used to quantify the elastic modulus. However, in current methods, shear waves are measured near the surface with an interference of surface waves. In this study, we developed acoustic radiation force (ARF) orthogonal excitation optical coherence elastography (ARFOE-OCE) to visualize shear waves in 3D. This method uses acoustic force perpendicular to the OCT beam to excite shear waves in internal specimens and uses Doppler variance method to visualize shear wave propagation in 3D. The measured propagation of shear waves agrees well with the simulation results obtained from finite element analysis (FEA). Orthogonal acoustic excitation allows this method to measure the shear modulus in a deeper specimen which extends the elasticity measurement range beyond the OCT imaging depth. The results show that the ARFOE-OCE system has the ability to noninvasively determine the 3D elastic map.
authors.affiliation: Beckman Laser Institute, University of California, Irvine, Irvine, California 92612, USA.
authors.forename: Jiang
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Beckman Laser Institute, University of California, Irvine, Irvine, California 92612, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Qi
authors.affiliation: Department of Biomedical Engineering, University of California, Irvine, Irvine, California 92697, USA.
authors.forename: Yusi
authors.initials: Y
authors.lastname: Miao
authors.affiliation: Department of Biomedical Engineering, University of Southern California, Los Angeles, California 90089, USA.
authors.forename: Teng
authors.initials: T
authors.lastname: Ma
authors.affiliation: Beckman Laser Institute, University of California, Irvine, Irvine, California 92612, USA.|College of Science, Shanghai Institute of Technology, Shanghai 201418, China.
authors.forename: Cuixia
authors.initials: C
authors.lastname: Dai
authors.affiliation: Beckman Laser Institute, University of California, Irvine, Irvine, California 92612, USA.|Department of Biomedical Engineering, University of California, Irvine, Irvine, California 92697, USA.
authors.forename: Yueqiao
authors.initials: Y
authors.lastname: Qu
authors.affiliation: Beckman Laser Institute, University of California, Irvine, Irvine, California 92612, USA.|Department of Biomedical Engineering, University of California, Irvine, Irvine, California 92697, USA.
authors.forename: Youmin
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Biomedical Engineering, University of California, Irvine, Irvine, California 92697, USA.
authors.forename: Yiwei
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Biomedical Engineering, University of Southern California, Los Angeles, California 90089, USA.
authors.forename: Qifa
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: Beckman Laser Institute, University of California, Irvine, Irvine, California 92612, USA.|Department of Biomedical Engineering, University of California, Irvine, Irvine, California 92697, USA.
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Chen
mesh_terms: D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques; D020342:Finite Element Analysis; D021621:Imaging, Three-Dimensional; D055595:Mechanical Phenomena; D019047:Phantoms, Imaging; D041623:Tomography, Optical Coherence