title: [Treatment and progression of acute communautary osteoarticular infections in healthy children: A retrospective monocentric study of 64 patients].
abstract: BACKGROUND
  The prognosis of osteoarticular infections has improved over the past 20 years but it still remains potentially severe. The treatment of these infections has been simplified and shortened. In 2008, the Pediatric Infectious Disease Group (GPIP) established new therapeutic guidelines in order to standardize treatment in France. The aim of this study is to analyze practices in a Parisian hospital and assess the efficacy of this treatment in short and medium terms.
  
  
  METHODS
  This retrospective study focused on patients older than 3 months, without comorbidities, who were hospitalized for an acute osteoarticular infection in 2012 at Trousseau Hospital (Paris), with a follow-up of at least 4 weeks. The patients were selected from the hospital register.
  
  
  RESULTS
  The study included 64 patients of 156, who were admitted for examination with a diagnosis of acute osteoarticular infection, bacteriologically confirmed (29/64) or presumed on the basis of bacteriological evidence (35/64). The median age of the patients was 22 months. Of the patients, 78 % were febrile; 35 patients had arthritis (54.7 %), 21 osteomyelitis (32.8 %), seven osteoarthritis (10.9 %), and one spondylitis. Preferential localizations were the knees and hips; 61 % of arthritis cases were diagnosed with ultrasound, 54 % of osteomyelitis cases with scintigraphy. The two main microorganisms found were Kingella kingae (62.1 %) and Staphylococcus aureus (24.1 %). In 98 % of cases, patients were treated by cefamandole, with or without gentamicine, for a median duration of 3 days (1-10) intravenously, with oral relay by amoxicillin-clavulanic acid, for a total duration of 6 weeks, but in association with rifampicin in 40 % of cases without explanation. The median follow-up was 13 weeks, with a treatment success rate of 86 %.
  
  
  CONCLUSIONS
  The study of local practices showed us that the GPIP guidelines are not followed, with the duration of oral treatment being too long. The trend in therapy is toward short treatments of 10-20 days, with a shorter intravenous phase.
authors.affiliation: Service de pédiatrie générale, hôpital Armand-Trousseau, 26, avenue du Dr-Arnold-Netter, 75012 Paris, France. Electronic address: anais.lemoine@aphp.fr.
authors.forename: A
authors.initials: A
authors.lastname: Lemoine
authors.affiliation: Faculté de médecine, université Claude-Bernard Lyon 1, 69622 Lyon, France.
authors.forename: F
authors.initials: F
authors.lastname: Baudin
authors.affiliation: Service de chirurgie orthopédique pédiatrique, hôpital Armand-Trousseau, 26, avenue du Dr-Arnold-Netter, 75012 Paris, France; Département hospitalo-universitaire « Maladies musculo-squelettiques et innovations thérapeutiques » (DHU-MAMUTH), hôpital Armand-Trousseau, 26, avenue du Dr-Arnold-Netter, 75012 Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Vialle
authors.affiliation: Service de pédiatrie générale, hôpital Armand-Trousseau, 26, avenue du Dr-Arnold-Netter, 75012 Paris, France; Groupe de pathologie infectieuse pédiatrique de la Société française de pédiatrie, hôpital Armand-Trousseau, 26, avenue du Dr-Arnold-Netter, 75012 Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Grimprel
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002675:Child, Preschool; D004334:Drug Administration Schedule; D005260:Female; D005602:France; D019983:Guideline Adherence; D006801:Humans; D007223:Infant; D008297:Male; D010019:Osteomyelitis / Q000188:drug therapy* / Q000382:microbiology; D017410:Practice Guidelines as Topic; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents