title: Venous thromboembolism in chronic kidney disease: epidemiology, the role of proteinuria, CKD severity and therapeutics.
abstract: The worldwide prevalence of chronic kidney disease is 10-15 % of the adult population, is rising and increases susceptibility to venous thromboembolism (VTE). In this narrative review we discuss the underlying evidence behind the association of VTE/CKD and examine the role of worsening CKD stage, proteinuria, and the risk of recurrent VTE. As CKD may alter therapeutic options we discuss the role of emerging therapies, the non-vitamin K oral anticoagulants (NOAC), in the treatment of VTE.
authors.affiliation: Division of Internal Medicine, University of Ottawa, Ottawa, Canada.
authors.forename: Chrisanna
authors.initials: C
authors.lastname: Dobrowolski
authors.affiliation: Division of Nephrology, University of Ottawa, Ottawa, Canada.
authors.forename: Edward G
authors.initials: EG
authors.lastname: Clark
authors.affiliation: Division of Nephrology, University of Ottawa, Ottawa, Canada. Msood@toh.on.ca.|The Ottawa Hospital Research Institute, The Ottawa Hospital, Civic campus, 2-014 Administrative Services Building, 1053 Carling Avenue, Box 693, Ottawa, ON, K1Y 4E9, Canada. Msood@toh.on.ca.
authors.forename: Manish M
authors.initials: MM
authors.lastname: Sood
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D006801:Humans; D011507:Proteinuria / Q000150:complications; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology*; D012720:Severity of Illness Index; D054556:Venous Thromboembolism / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology
chemical_list: D000925:Anticoagulants
keywords: Albuminuria; Chronic kidney disease; Epidemiology; Non-vitamin K antagonist oral anticoagulants; Venous thromboembolism