title: Stem Cells for Modeling and Therapy of Parkinson's Disease.
abstract: Parkinson's disease (PD) is the second most frequent neurodegenerative disease after Alzheimer's disease, which is characterized by a low level of dopamine being expressing in the striatum and a deterioration of dopaminergic neurons (DAn) in the substantia nigra pars compacta. Generation of PD-derived DAn, including differentiation of human embryonic stem cells, human neural stem cells, human-induced pluripotent stem cells, and direct reprogramming, provides an ideal tool to model PD, creating the possibility of mimicking key essential pathological processes and charactering single-cell changes in vitro. Furthermore, thanks to the understanding of molecular neuropathogenesis of PD and new advances in stem-cell technology, it is anticipated that optimal functionally transplanted DAn with targeted correction and transgene-free insertion will be generated for use in cell transplantation. This review elucidates stem-cell technology for modeling PD and offering desired safe cell resources for cell transplantation therapy.
authors.affiliation: 1 Center for Regenerative and Translational Medicine, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine) , Guangzhou, China .|2 Department of Neurology, Zhujiang Hospital of Southern Medical University , Guangzhou, China .
authors.forename: Qingxi
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: 1 Center for Regenerative and Translational Medicine, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine) , Guangzhou, China .|2 Department of Neurology, Zhujiang Hospital of Southern Medical University , Guangzhou, China .
authors.forename: Wanling
authors.initials: W
authors.lastname: Chen
authors.affiliation: 2 Department of Neurology, Zhujiang Hospital of Southern Medical University , Guangzhou, China .
authors.forename: Sheng
authors.initials: S
authors.lastname: Tan
authors.affiliation: 1 Center for Regenerative and Translational Medicine, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine) , Guangzhou, China .|3 Stem Cell Research Center, Fujian Agriculture and Forestry University , Fuzhou, China .
authors.forename: Tongxiang
authors.initials: T
authors.lastname: Lin
mesh_terms: D000818:Animals; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D006801:Humans; D058953:Neural Stem Cells / Q000166:cytology*; D010300:Parkinson Disease / Q000628:therapy*; D033581:Stem Cell Transplantation
keywords: Parkinson's disease; cell therapy stem cells; modeling disease