title: Extraocular Sebaceous Carcinoma-A Clinicopathologic Reassessment.
abstract: Sebaceous carcinoma is an aggressive adnexal neoplasm with sebaceous differentiation. Few reports have described the histopathologic characteristics of the sebaceous carcinoma occurring extraocularly. Seventy-two cases of extraocular sebaceous carcinoma were identified from the database of a Dermatopathology Laboratory from January 1, 2007 to May 31, 2013. More cases occurred in men (60%), with a mean age at diagnosis of 65.8 years (range 39-99 years). Neoplasms were histopathologically classified as well-differentiated (22%), moderately differentiated (67%), and poorly differentiated (11%). Sixty-seven percent (67%) of cases demonstrated a squamoid growth pattern and thirty-three percent (33%) demonstrated a basaloid growth pattern. A majority of the neoplasms histopathologically classified as well-differentiated (94%) and moderately differentiated (65%) demonstrated a squamoid growth pattern. Ten percent (10%) of cases exhibited cystic histopathologic changes. The histopathological features reported in this study aid in the understanding of extraocular sebaceous carcinoma and its eventual diagnosis and classification.
authors.affiliation: Department of Dermatology, University of Puerto Rico School of Medicine, San Juan, PR.
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Candelario
authors.forename: Julio E
authors.initials: JE
authors.lastname: Sánchez
authors.forename: Jorge L
authors.initials: JL
authors.lastname: Sánchez
authors.forename: Rafael F
authors.initials: RF
authors.lastname: Martín-García
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Rochet
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002277:Carcinoma / Q000145:classification / Q000473:pathology*; D002454:Cell Differentiation; D016208:Databases, Factual; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011647:Puerto Rico; D012189:Retrospective Studies; D012626:Sebaceous Gland Neoplasms / Q000145:classification / Q000473:pathology*; D012627:Sebaceous Glands / Q000473:pathology*