title: Human Cancer Cell Line Based Approach of 1,3,4-thiadiazole and its Fused Ring: A Comprehensive Review.
abstract: The chemistry of heterocyclic containing, 1,3,4-thiadiazole has been an interesting field of study from ancient years. Subsequently, 1,3,4-thiadiazole nucleus constitutes a significant class of compounds for new drug development. Recently, various 1,3,4-thiadiazole derivatives synthesized and evaluated their biological activities including antimicrobial, antituberculosis, antioxidant, anti-inflammatory, anticonvulsants, antidepressant and anxiolytic, antihypertensive, anticancer and antifungal activity. The search for anticancer compounds with more selective activities and lower side effect continues to be an active area of argument examination in medicinal chemistry. This review elaborately described the medicinal chemistry, their structural activity relationship, and anticancer properties with respect to human cell line based approach related to synthesized 1,3,4-thiadiazole derivatives.
authors.forename: Vinit
authors.initials: V
authors.lastname: Raj
authors.forename: Amit
authors.initials: A
authors.lastname: Rai
authors.affiliation: Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, VidyaVihar, Rai Bareli Road, Lucknow-226025, India.
authors.forename: Sudipta
authors.initials: S
authors.lastname: Saha
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor / Q000379:methods*; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D013830:Thiadiazoles; C058949:1,3,4-thiadiazole
keywords: 1,3,4-thiadiazole; cancer cell lines; mechanism of action; structure-activity-relationship