title: A New SEYHAN's Approach in Case of Heterogeneity of Regression Slopes in ANCOVA.
abstract: In this study, when the assumptions of linearity and homogeneity of regression slopes of conventional ANCOVA are not met, a new approach named as SEYHAN has been suggested to use conventional ANCOVA instead of robust or nonlinear ANCOVA. The proposed SEYHAN's approach involves transformation of continuous covariate into categorical structure when the relationship between covariate and dependent variable is nonlinear and the regression slopes are not homogenous. A simulated data set was used to explain SEYHAN's approach. In this approach, we performed conventional ANCOVA in each subgroup which is constituted according to knot values and analysis of variance with two-factor model after MARS method was used for categorization of covariate. The first model is a simpler model than the second model that includes interaction term. Since the model with interaction effect has more subjects, the power of test also increases and the existing significant difference is revealed better. We can say that linearity and homogeneity of regression slopes are not problem for data analysis by conventional linear ANCOVA model by helping this approach. It can be used fast and efficiently for the presence of one or more covariates.
authors.affiliation: Department of Biostatistics and Medical Informatics, Faculty of Medicine, Duzce University, Duzce, Turkey.
authors.forename: Handan
authors.initials: H
authors.lastname: Ankarali
authors.affiliation: Department of Biostatistics and Medical Informatics, Faculty of Medicine, Duzce University, Duzce, Turkey. sengulcangur@duzce.edu.tr.
authors.forename: Sengul
authors.initials: S
authors.lastname: Cangur
authors.affiliation: Department of Physiology, Faculty of Medicine, Duzce University, Duzce, Turkey.
authors.forename: Seyit
authors.initials: S
authors.lastname: Ankarali
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D015992:Body Mass Index; D002648:Child; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012044:Regression Analysis; D055815:Young Adult
keywords: ANCOVA; Generalized Johnson–Neyman; Homogeneity of regression slopes; Nonlinear ANCOVA; Robust ANCOVA