title: Fabrication of RNA 3D Nanoprisms for Loading and Protection of Small RNAs and Model Drugs.
abstract: Constructing containers with defined shape and size to load and protect therapeutics and subsequently control their release in the human body has long been a dream. The fabrication of 3D RNA prisms, characterized by atomic force microscopy, cryo-electron microscopy, dynamic light scattering, and polyacrylamide gel electrophoresis, is reported for the loading and protection of small molecules, proteins, small RNA molecules, and their controlled release.
authors.affiliation: Nanobiotechnology Center, Markey Cancer Center, Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, 40536, USA.|Department of Chemistry, Ball State University, Muncie, IN, 47306, USA.
authors.forename: Emil F
authors.initials: EF
authors.lastname: Khisamutdinov
authors.affiliation: Nanobiotechnology Center, Markey Cancer Center, Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, 40536, USA.|College of Pharmacy, Department of Physiology and Cell Biology, College of Medicine, and Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Jasinski
authors.affiliation: Nanobiotechnology Center, Markey Cancer Center, Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, 40536, USA.|College of Pharmacy, Department of Physiology and Cell Biology, College of Medicine, and Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.
authors.forename: Kaiming
authors.initials: K
authors.lastname: Zhang
authors.affiliation: National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.
authors.forename: Wah
authors.initials: W
authors.lastname: Chiu
authors.affiliation: Nanobiotechnology Center, Markey Cancer Center, Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, 40536, USA.|College of Pharmacy, Department of Physiology and Cell Biology, College of Medicine, and Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
authors.forename: Peixuan
authors.initials: P
authors.lastname: Guo
mesh_terms: D020285:Cryoelectron Microscopy; D016503:Drug Delivery Systems; D065546:Drug Liberation; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D018625:Microscopy, Atomic Force; D049329:Nanostructures / Q000008:administration & dosage* / Q000737:chemistry*; D036103:Nanotechnology; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry*; D011506:Proteins / Q000008:administration & dosage / Q000737:chemistry; D012313:RNA / Q000008:administration & dosage* / Q000737:chemistry*
chemical_list: D004364:Pharmaceutical Preparations; D011506:Proteins; D012313:RNA
keywords: RNA drug encapsulation; RNA nanocontainers; nanobiotechnology; nanotechnology; pRNA 3WJ motif