title: Evaluation of the factors influencing brain language laterality in presurgical planning.
abstract: Brain lesions cause functional deficits, and one treatment for this condition is lesion resection. In most cases, presurgical planning (PSP) and the information from laterality indices are necessary for maximum preservation of the critical functions after surgery. Language laterality index (LI) is reliably estimated using functional magnetic resonance imaging (fMRI); however, this measure is under the influence of some external factors. In this study, we investigated the influence of a number of factors on language LI, using data from 120 patients (mean age=35.65 (±13.4) years) who underwent fMRI for PSP. Using two proposed language tasks from our previous works, brain left hemisphere was showed to be dominant for the language function, although a higher LI was obtained using the "Word Generation" task, compared to the "Reverse Word Reading". In addition, decline of LIs with age, and lower LI when the lesion invaded brain language area were observed. Meanwhile, gender, lesion side (affected hemisphere), LI calculation strategy, and fMRI analysis Z-values did not statistically show any influences on the LIs. Although fMRI is widely used to estimate language LI, it is shown here that in order to present a reliable language LI and to correctly select the dominant hemisphere of the brain, the influence of external factors should be carefully considered.
authors.affiliation: Neuroimaging and Analysis Group, Research Center for Cellular and Molecular Imaging, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Seyed Amir Hossein
authors.initials: SA
authors.lastname: Batouli
authors.affiliation: Neuroimaging and Analysis Group, Research Center for Cellular and Molecular Imaging, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Nafiseh
authors.initials: N
authors.lastname: Hasani
authors.affiliation: Neuroimaging and Analysis Group, Research Center for Cellular and Molecular Imaging, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Sara
authors.initials: S
authors.lastname: Gheisari
authors.affiliation: School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Behzad
authors.affiliation: Neuroimaging and Analysis Group, Research Center for Cellular and Molecular Imaging, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: oghabian@sina.tums.ac.ir.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Oghabian
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D055592:Biophysical Phenomena; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D001931:Brain Mapping / Q000379:methods* / Q000706:statistics & numerical data; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D002648:Child; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D055815:Young Adult
keywords: Functional magnetic resonance imaging; Language laterality index; Presurgical planning