title: Applications of Cell Microencapsulation.
abstract: The goal of this chapter is to provide an overview of the different purposes for which the cell microencapsulation technology can be used. These include immunoisolation of non-autologous cells used for cell therapy; immobilization of cells for localized (targeted) delivery of therapeutic products to ablate, repair, or regenerate tissue; simultaneous delivery of multiple therapeutic agents in cell therapy; spatial compartmentalization of cells in complex tissue engineering; expansion of cells in culture; and production of different probiotics and metabolites for industrial applications. For each of these applications, specific examples are provided to illustrate how the microencapsulation technology can be utilized to achieve the purpose. However, successful use of the cell microencapsulation technology for whatever purpose will ultimately depend upon careful consideration for the choice of the encapsulating polymers, the method of fabrication (cross-linking) of the microbeads, which affects the permselectivity, the biocompatibility and the mechanical strength of the microbeads as well as environmental parameters such as temperature, humidity, osmotic pressure, and storage solutions.The various applications discussed in this chapter are illustrated in the different chapters of this book and where appropriate relevant images of the microencapsulation products are provided. It is hoped that this outline of the different applications of cell microencapsulation would provide a good platform for tissue engineers, scientists, and clinicians to design novel tissue constructs and products for therapeutic and industrial applications.
authors.affiliation: Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA. eopara@wakehealth.edu.|Virginia Tech-Wake Forest School of Biomedical Engineering & Sciences (SBES), Wake Forest School of Medicine, Winston-Salem, NC, USA. eopara@wakehealth.edu.
authors.forename: Emmanuel C
authors.initials: EC
authors.lastname: Opara
mesh_terms: D000818:Animals; D001419:Bacteria / Q000166:cytology / Q000378:metabolism; D001672:Biocompatible Materials / Q000737:chemistry*; D018929:Cell Culture Techniques / Q000379:methods; D064987:Cell- and Tissue-Based Therapy / Q000379:methods; D018914:Cells, Immobilized / Q000166:cytology* / Q000378:metabolism / Q000637:transplantation; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008863:Microspheres; D009369:Neoplasms / Q000628:therapy; D011108:Polymers / Q000737:chemistry*; D019936:Probiotics / Q000378:metabolism; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D011108:Polymers
keywords: Applications; Cancer treatment; Cell therapy; Drug delivery; Goals; Immunoisolation; Microencapsulation; Probiotics; Tissue engineering