title: Meta-analysis of the association between vitiligo and the level of superoxide dismutase or malondialdehyde.
abstract: BACKGROUND
  There are conflicting reports on the correlation between vitiligo and the levels of either superoxide dismutase (SOD) or malondialdehyde (MDA).
  
  
  OBJECTIVE
  To clarify the association between vitiligo and SOD or MDA.
  
  
  METHODS
  Relevant published articles were searched according to our eligibility criteria. A meta-analysis was conducted to pool estimates of the standardized mean difference (SMD) with 95% CI.
  
  
  RESULTS
  Patients with either the active or stable vitiligo had higher levels of both SOD (stable: SMD = 1.61, 95% CI 0.66-2.56, P = 0.001; active: SMD = 2.56, 95% CI 1.13-3.99, P < 0.001) and MDA (stable: SMD = 2.70, 95% CI 1.81-3.59, P < 0.001; active: SMD = 3.50, 95% CI 2.29-4.71, P < 0.001), compared with healthy controls.
  
  
  CONCLUSIONS
  This meta-analysis showed a significant association between vitiligo and high levels of both SOD and MDA.
authors.affiliation: Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang, PR China.
authors.forename: M-H
authors.initials: MH
authors.lastname: Shi
authors.affiliation: Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang, PR China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang, PR China.
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang, PR China.
authors.forename: Y-F
authors.initials: YF
authors.lastname: Cai
authors.affiliation: Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang, PR China.
authors.forename: M
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang, PR China.
authors.forename: X-H
authors.initials: XH
authors.lastname: Gao
authors.affiliation: Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang, PR China.
authors.forename: H-D
authors.initials: HD
authors.lastname: Chen
mesh_terms: D006801:Humans; D008315:Malondialdehyde / Q000378:metabolism*; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000378:metabolism*; D014820:Vitiligo / Q000378:metabolism*
chemical_list: D008315:Malondialdehyde; D013482:Superoxide Dismutase