title: Observational Cohort Studies and the Challenges of In Silico Experiments.
authors.affiliation: Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee2Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee3Department of Psychiatry, Vanderbilt University Medical Center, Nashville, Tennessee.
authors.forename: Colin G
authors.initials: CG
authors.lastname: Walsh
authors.affiliation: Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee4Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.
authors.forename: Kevin B
authors.initials: KB
authors.lastname: Johnson
mesh_terms: D016022:Case-Control Studies; D015331:Cohort Studies; D003198:Computer Simulation; D003430:Cross-Sectional Studies; D006801:Humans; D008954:Models, Biological; D019370:Observation; D012107:Research Design