title: Targeted Co-delivery of PTX and TR3 siRNA by PTP Peptide Modified Dendrimer for the Treatment of Pancreatic Cancer.
abstract: A new type of tumor-targeted nanovehicle peptide-conjugated PSPG (PSPGP) is successfully synthesized for co-delivery of paclitaxel (PTX) and TR3 small interfering RNA (siRNA). In vitro and in vivo investigations demonstrate that the redox-responsive PSPGP exhibit enhanced endosomal escape and intracellular degradation, which facilitate PTX and TR3 siRNA release, effectively improving the antitumor efficacy.
authors.affiliation: Institute of Chemical Biology and Pharmaceutical Chemistry, Department of Chemistry, Zhejiang University, Hangzhou, 310028, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.affiliation: Institute of Chemical Biology and Pharmaceutical Chemistry, Department of Chemistry, Zhejiang University, Hangzhou, 310028, China.|College of Life Sciences, Tarim University, Alar, 843300, China.
authors.forename: Hebin
authors.initials: H
authors.lastname: Wang
authors.affiliation: Institute of Chemical Biology and Pharmaceutical Chemistry, Department of Chemistry, Zhejiang University, Hangzhou, 310028, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
authors.affiliation: College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310032, China.
authors.forename: Qinglian
authors.initials: Q
authors.lastname: Hu
authors.affiliation: Institute of Chemical Biology and Pharmaceutical Chemistry, Department of Chemistry, Zhejiang University, Hangzhou, 310028, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Yao
authors.affiliation: Center for Bionanoengineering and State Key Laboratory for Chemical Engineering, Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China.
authors.forename: Youqing
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD, 20892, USA.
authors.forename: Guocan
authors.initials: G
authors.lastname: Yu
authors.affiliation: Institute of Chemical Biology and Pharmaceutical Chemistry, Department of Chemistry, Zhejiang University, Hangzhou, 310028, China.
authors.forename: Guping
authors.initials: G
authors.lastname: Tang
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D050091:Dendrimers / Q000737:chemistry*; D006801:Humans; D007275:Injections, Intravenous; D051379:Mice; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1 / Q000378:metabolism*; D017239:Paclitaxel / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use*; D010190:Pancreatic Neoplasms / Q000188:drug therapy*; D010316:Particle Size; D010455:Peptides / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D034741:RNA, Small Interfering / Q000008:administration & dosage*; D055672:Static Electricity; D013696:Temperature; D023041:Xenograft Model Antitumor Assays
chemical_list: D050091:Dendrimers; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1; D010455:Peptides; D034741:RNA, Small Interfering; D017239:Paclitaxel
keywords: co-delivery; nanoparticles; paclitaxel; pancreatic cancer; siRNA