title: Brain18F-FDG PET Metabolic Abnormalities in Patients with Long-Lasting Macrophagic Myofascitis.
abstract: The aim of this study was to characterize brain metabolic abnormalities in patients with macrophagic myofascitis (MMF) and the relationship with cognitive dysfunction through the use of PET with18F-FDG.Methods:18F-FDG PET brain imaging and a comprehensive battery of neuropsychological tests were performed in 100 consecutive MMF patients (age [mean ± SD], 45.9 ± 12 y; 74% women). Images were analyzed with statistical parametric mapping (SPM12). Through the use of analysis of covariance, all18F-FDG PET brain images of MMF patients were compared with those of a reference population of 44 healthy subjects similar in age (45.4 ± 16 y;P= 0.87) and sex (73% women;P= 0.88). The neuropsychological assessment identified 4 categories of patients: those with no significant cognitive impairment (n= 42), those with frontal subcortical (FSC) dysfunction (n= 29), those with Papez circuit dysfunction (n= 22), and those with callosal disconnection (n= 7).Results:In comparison with healthy subjects, the whole population of patients with MMF exhibited a spatial pattern of cerebral glucose hypometabolism (P< 0.001) involving the occipital lobes, temporal lobes, limbic system, cerebellum, and frontoparietal cortices, as shown by analysis of covariance. The subgroup of patients with FSC dysfunction exhibited a larger extent of involved areas (35,223 voxels vs. 13,680 voxels in the subgroup with Papez circuit dysfunction and 5,453 voxels in patients without cognitive impairment). Nonsignificant results were obtained for the last subgroup because of its small population size.Conclusion:Our study identified a peculiar spatial pattern of cerebral glucose hypometabolism that was most marked in MMF patients with FSC dysfunction. Further studies are needed to determine whether this pattern could represent a diagnostic biomarker of MMF in patients with chronic fatigue syndrome and cognitive dysfunction.
authors.affiliation: Department of Nuclear Medicine, H. Mondor Hospital, Assistance Publique-Hôpitaux de Paris/Paris-Est University, Créteil, France axel.vandergucht@gmail.com.
authors.forename: Axel
authors.initials: A
authors.lastname: Van Der Gucht
authors.affiliation: Deparment of Neurology, H. Mondor Hospital, Assistance Publique-Hôpitaux de Paris/Paris-Est University, Créteil, France.|INSERM U955-Team 10, Créteil, France.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Aoun Sebaiti
authors.affiliation: Department of Nuclear Medicine, CHU La Timone, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Guedj
authors.affiliation: INSERM U955-Team 10, Créteil, France.|Department of Pathology, H. Mondor Hospital, Assistance Publique-Hôpitaux de Paris/Paris-Est University, Créteil, France.|Reference Center for Neuromuscular Disorders, H. Mondor Hospital, Assistance Publique-Hôpitaux de Paris, Créteil, France.
authors.forename: Jessie
authors.initials: J
authors.lastname: Aouizerate
authors.affiliation: INSERM U955-Team 10, Créteil, France.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Yara
authors.affiliation: INSERM U955-Team 10, Créteil, France.|Department of Pathology, H. Mondor Hospital, Assistance Publique-Hôpitaux de Paris/Paris-Est University, Créteil, France.|Reference Center for Neuromuscular Disorders, H. Mondor Hospital, Assistance Publique-Hôpitaux de Paris, Créteil, France.
authors.forename: Romain K
authors.initials: RK
authors.lastname: Gherardi
authors.affiliation: Department of Nuclear Medicine, H. Mondor Hospital, Assistance Publique-Hôpitaux de Paris/Paris-Est University, Créteil, France.
authors.forename: Eva
authors.initials: E
authors.lastname: Evangelista
authors.affiliation: Department of Nuclear Medicine, H. Mondor Hospital, Assistance Publique-Hôpitaux de Paris/Paris-Est University, Créteil, France.
authors.forename: Julia
authors.initials: J
authors.lastname: Chalaye
authors.affiliation: Department of Nuclear Medicine, H. Mondor Hospital, Assistance Publique-Hôpitaux de Paris/Paris-Est University, Créteil, France.
authors.forename: Anne-Ségolène
authors.initials: AS
authors.lastname: Cottereau
authors.affiliation: Nuclear Medecine & Nancyclotep Experimental Imaging Platform, CHU Nancy, Nancy, France; and.
authors.forename: Antoine
authors.initials: A
authors.lastname: Verger
authors.affiliation: Deparment of Neurology, H. Mondor Hospital, Assistance Publique-Hôpitaux de Paris/Paris-Est University, Créteil, France.|INSERM U955-Team 1, Créteil, France.
authors.forename: Anne-Catherine
authors.initials: AC
authors.lastname: Bachoud-Levi
authors.affiliation: Department of Nuclear Medicine, H. Mondor Hospital, Assistance Publique-Hôpitaux de Paris/Paris-Est University, Créteil, France.
authors.forename: Mukedaisi
authors.initials: M
authors.lastname: Abulizi
authors.affiliation: Department of Nuclear Medicine, H. Mondor Hospital, Assistance Publique-Hôpitaux de Paris/Paris-Est University, Créteil, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Itti
authors.affiliation: INSERM U955-Team 10, Créteil, France.|Department of Pathology, H. Mondor Hospital, Assistance Publique-Hôpitaux de Paris/Paris-Est University, Créteil, France.|Reference Center for Neuromuscular Disorders, H. Mondor Hospital, Assistance Publique-Hôpitaux de Paris, Créteil, France.
authors.forename: François-Jérôme
authors.initials: FJ
authors.lastname: Authier
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D001928:Brain Diseases, Metabolic / Q000000981:diagnostic imaging / Q000378:metabolism*; D002908:Chronic Disease; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000378:metabolism*; D005208:Fasciitis / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009220:Myositis / Q000000981:diagnostic imaging / Q000378:metabolism*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose
keywords: PET/CT; aluminum hydroxide; brain 18F-FDG PET; macrophagic myofascitis; neurology; statistical parametric mapping