title: APOE ε4 and Memory Among Patients With Heart Failure.
abstract: Twenty-three percent to 50% of heart failure (HF) patients have memory loss. Objectives were to (a) characterize major allelic frequency of 2 variants in apolipoprotein ( APOE) gene in HF patients, (b) evaluate differences in memory and serum brain-derived neurotrophic factor (BDNF) levels based on APOE ε4 allele(s), and (c) estimate effect sizes (ESs) and confidence intervals (CIs). In this pilot, 29 HF patients were enrolled and 26 completed. Recall and delayed recall memory were measured at baseline and 12 weeks. Serum was collected at baseline and 8 weeks. Seven (24.1%) patients had APOE ε4 allele. No significant differences were found in recall and delayed recall memory or serum BDNF levels based on APOE ε4 allele. ESs were small to medium; CIs indicated ES precision was small. Future studies are needed to fully understand how genotypic and neuropsychological phenotypic variables influence response to computerized cognitive training.
authors.affiliation: 1 Indiana University School of Nursing, Indianapolis, IN, USA.
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Pressler
authors.affiliation: 2 University of Michigan School of Nursing, Ann Arbor, MI, USA.
authors.forename: Jordan M
authors.initials: JM
authors.lastname: Harrison
authors.affiliation: 2 University of Michigan School of Nursing, Ann Arbor, MI, USA.
authors.forename: Marita
authors.initials: M
authors.lastname: Titler
authors.affiliation: 3 University of Michigan School of Medicine, Division of Internal Medicine, Cardiology, Ann Arbor, MI, USA.
authors.forename: Todd M
authors.initials: TM
authors.lastname: Koelling
authors.affiliation: 1 Indiana University School of Nursing, Indianapolis, IN, USA.
authors.forename: Miyeon
authors.initials: M
authors.lastname: Jung
authors.affiliation: 4 University of Maryland School of Nursing, Baltimore, MD, USA.
authors.forename: Susan G
authors.initials: SG
authors.lastname: Dorsey
authors.affiliation: 5 Indiana University School of Medicine, Department of Biostatistics, Indianapolis, IN, USA.
authors.forename: Giorgos
authors.initials: G
authors.lastname: Bakoyannis
authors.affiliation: 2 University of Michigan School of Nursing, Ann Arbor, MI, USA.
authors.forename: Penny L
authors.initials: PL
authors.lastname: Riley
authors.affiliation: 6 University of Florida College of Public Health and Health Professions and College of Medicine, Gainesville, FL, USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Hoyland-Domenico
authors.affiliation: 7 University of Michigan School of Medicine, Neuropsychology Section, Department of Psychiatry, Neurology, and Psychology, Ann Arbor, MI, USA.
authors.forename: Bruno
authors.initials: B
authors.lastname: Giordani
mesh_terms: D000483:Alleles; D053327:Apolipoprotein E4 / Q000235:genetics*; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood; D003071:Cognition / Q000502:physiology; D005260:Female; D005838:Genotype; D006333:Heart Failure / Q000235:genetics*; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D011939:Mental Recall / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests
chemical_list: D053327:Apolipoprotein E4; D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human
keywords: APOE ε4; BDNF; apolipoprotein E; brain-derived neurotrophic factor; cognition; heart failure; memory