title: Prostaglandin E2 induction of labor and cervical ripening for term isolated oligohydramnios in pregnant women with Bishop score ≤ 5.
abstract: BACKGROUND
  We aimed to evaluate the efficacy and safety of dinoprostone for cervical ripening and labor induction in patients with term oligohydramnios and Bishop score ≤ 5.
  
  
  METHODS
  This was a prospective case-control study, which included 104 consecutive women with a Bishop score≤5. Participants were divided into two groups. Women with term isolated oligohydramnios and Bishop score≤5 underwent induction of labor with a vaginal insert containing 10-mg timed-release dinoprostone (prostaglandin E2; Group A, n=40). The control group, Group B, consisted of 64 cases of pregnancy with normal amniotic fluid volume (amniotic fluid index≥5 cm) and Bishop score≤5, and was matched for patient's age and parity. The primary outcome was time from induction to delivery; the secondary outcomes were the caesarean section (CS) rate, uterine hyperstimulation, rate of failed induction, and neonatal complications.
  
  
  RESULTS
  The mean time interval from induction to delivery was not different between the two groups (p=0.849), but there was a statistically significant difference between the groups in terms of the CS rate (p=0.005). There were no differences between the groups in neonatal outcome or perinatal morbidity or mortality.
  
  
  CONCLUSIONS
  Dinoprostone appears to be a safe alternative for induction of labor in pregnancies with oligohydramnios. Induction of labor with dinoprostone in term pregnancies with isolated oligohydramnios is associated with increased rate of CS but there is no higher risk of perinatal complications.
authors.affiliation: Zekai Tahir Burak Woman's Health, Research and Education Hospital, Department of Obstetrics and Gynecology, Ankara, Turkey. Electronic address: h_kansu@yahoo.com.
authors.forename: Hatice
authors.initials: H
authors.lastname: Kansu-Celik
authors.affiliation: Zekai Tahir Burak Woman's Health, Research and Education Hospital, Department of Obstetrics and Gynecology, Ankara, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Gun-Eryılmaz
authors.affiliation: Zekai Tahir Burak Woman's Health, Research and Education Hospital, Department of Obstetrics and Gynecology, Ankara, Turkey.
authors.forename: Nasuh Utku
authors.initials: NU
authors.lastname: Dogan
authors.affiliation: Zekai Tahir Burak Woman's Health, Research and Education Hospital, Department of Obstetrics and Gynecology, Ankara, Turkey.
authors.forename: Seval
authors.initials: S
authors.lastname: Haktankaçmaz
authors.affiliation: Zekai Tahir Burak Woman's Health, Research and Education Hospital, Department of Obstetrics and Gynecology, Ankara, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Cinar
authors.affiliation: Zekai Tahir Burak Woman's Health, Research and Education Hospital, Department of Obstetrics and Gynecology, Ankara, Turkey.
authors.forename: Saynur Sarici
authors.initials: SS
authors.lastname: Yilmaz
authors.affiliation: Zekai Tahir Burak Woman's Health, Research and Education Hospital, Department of Obstetrics and Gynecology, Ankara, Turkey.
authors.forename: Cavidan
authors.initials: C
authors.lastname: Gülerman
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D020070:Cervical Ripening; D002585:Cesarean Section; D015232:Dinoprostone / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007751:Labor, Induced; D016104:Oligohydramnios / Q000628:therapy*; D011247:Pregnancy; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D015232:Dinoprostone
keywords: caesarean section rate; cervical ripening; dinoprostone; induction of labor; oligohydramnios