title: Eruptive disseminated Spitz nevi.
abstract: BACKGROUND
  The solitary form of Spitz nevus is a common clinical entity in children, typically occurring on the face and extremities. However, less frequent variants of Spitz nevi, such as agminated forms and eruptive disseminated Spitz nevi (EDSN), have been described. The agminated form is characterised by localised clusters or segmental distribution of Spitz nevi on the face, back, or extremities. First described as "eruptive juvenile melanomata", EDSN is the rarest clinical variant, consisting of a widespread eruption of Spitz nevi, most frequently involving the trunk, buttocks, and proximal limbs, and usually occurs in the second to third decade of life.
  
  
  OBJECTIVE
  To describe a case of EDSN and review the literature.
  
  
  METHODS
  Twenty-seven cases of EDSN, including a 12-year-old female patient with EDSN presented here, were reviewed.
  
  
  RESULTS
  EDSN generally exhibits an abrupt, eruptive onset (developing over few months), followed by a slow progressive course of new lesions that continue to appear over a long period, resulting in hundreds of papules and nodules. In all reported cases, the EDSN lesions involved the trunk, often affecting the legs and arms, and sometimes the scalp. A number of possible precipitating factors were reported.
  
  
  CONCLUSIONS
  A periodic self-examination, total body photography, a dermoscopic 3-6-month follow-up during the eruptive phase (extending to 9-12 months during the stable phase), and prompt surgical excision of lesions that may be malignant is recommended, however, to date, no malignant transformation of EDSN has been reported.
authors.affiliation: Institute of Dermatology, Catholic University of the Sacred Heart, Rome, Italy, Clinical Epidemiology Unit, IDI-IRCCS - FLMM, Rome, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Ricci
authors.affiliation: Clinical Epidemiology Unit, IDI-IRCCS - FLMM, Rome, Italy, Dermatology Unit, "Cristo Re" General Hospital, Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Paradisi
authors.affiliation: Laboratory of Dermatopathology, IDI-IRCCS - FLMM, Rome, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Annessi
authors.affiliation: Campus Bio-Medico University of Rome, Rome, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Paradisi
authors.affiliation: Clinical Epidemiology Unit, IDI-IRCCS - FLMM, Rome, Italy.
authors.forename: Damiano
authors.initials: D
authors.lastname: Abeni
mesh_terms: D002648:Child; D005121:Extremities; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000473:pathology*; D018332:Nevus, Epithelioid and Spindle Cell / Q000473:pathology*; D012535:Scalp; D012878:Skin Neoplasms / Q000473:pathology*; D060726:Torso
keywords: Reed nevi; Spitz nevi; disseminated; eruptive