title: Anionic chlorido(triphenyl)tin(IV) bearing N-phthaloylglycinato or 1,2,4-benzenetricarboxylato 1,2-anhydride ligands: potential cytotoxic and apoptosis-inducing agents against several types of cancer.
abstract: Two ionic triphenyltin(IV) chloride carboxylate compounds of the formula [NHEt3][Ph3SnCl(L)] [LH = N-phthaloylglycine (P-GlyH), 1; 1,2,4-benzenetricarboxylic 1,2-anhydride (BTCH), 2] were tested for the in vitro activity against 518A2 (melanoma), FaDu (head and neck carcinoma), HT-29 (colon cancer), MCF-7 (breast carcinoma), and SW1736 (thyroid cancer) cell lines. The ammonium salts of the carboxylic acids are found to be not active, while anionic [Ph3SnCl(L)]-exhibited high cytotoxicity in nM range, both higher activity and selectivity than cisplatin. Compounds 1 and 2 are inducing apoptosis, which was proved with the morphological and biochemical features such as membrane blebbing, translocation of phosphatidylserine, and DNA fragmentation. Thus, accumulation of cells in sub-G1 phase is observed. Both anionic organotin(IV) compounds showed potent cytotoxic and apoptotic properties against five cancer cell lines of various histogenetic origin.
authors.affiliation: Institute of Virology, University of Leipzig, Leipzig, Germany.
authors.forename: Denise
authors.initials: D
authors.lastname: Hübner
authors.affiliation: Department of Oral, Maxillary, Facial and Reconstructive Plastic Surgery, University Hospital of Leipzig, Leipzig, Germany.
authors.forename: Milena R
authors.initials: MR
authors.lastname: Kaluđerović
authors.affiliation: Departamento de Biología y Geología, Física y Química Inorgánica, E.S.C.E.T., Universidad Rey Juan Carlos, Móstoles, Madrid, Spain.
authors.forename: Santiago
authors.initials: S
authors.lastname: Gómez-Ruiz
authors.affiliation: Department of Bioorganic Chemistry, Leibniz-Institute of Plant Biochemistry, Halle (Saale), Germany.
authors.forename: Goran N
authors.initials: GN
authors.lastname: Kaluđerović
mesh_terms: D000838:Anions; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D017971:Tin Compounds / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000838:Anions; D017971:Tin Compounds
keywords: DNA laddering; apoptosis; cell cycle; cytotoxicity; organotin(IV) compounds