title: FROSTED BRANCH ANGIITIS IN METHIMAZOLE-INDUCED ANTINEUTROPHIL CYTOPLASMIC ANTIBODY-POSITIVE VASCULITIS.
abstract: OBJECTIVE
  To describe an unusual case of frosted branch angiitis that developed in a patient with acute onset systemic vasculitis possibly triggered by the antithyroid medication methimazole.
  
  
  METHODS
  We conducted a thorough review of the medical records of a 16-year-old female patient who presented with frosted branch angiitis. During the initial hospital admission, the patient underwent an extensive systemic workup to determine the etiology of her disease and ophthalmologic testing including fundus photographs and fluorescein angiography.
  
  
  RESULTS
  Our patient presented with a unilateral acute onset loss of vision, whose fundus examination revealed the pathognomonic features of frosted branch angiitis. Extensive systemic workup revealed an antineutrophilic cytoplasmic antibody-positive vasculitis, possibly triggered by methimazole.
  
  
  CONCLUSIONS
  This case is the first reported frosted branch angiitis associated with a drug-induced antineutrophilic cytoplasmic antibody-positive vasculitis triggered by methimazole.
authors.affiliation: Departments of Ophthalmology.
authors.forename: Kenzo J
authors.initials: KJ
authors.lastname: Koike
authors.affiliation: Departments of Ophthalmology.
authors.forename: Jeffrey P
authors.initials: JP
authors.lastname: Blice
authors.affiliation: Departments of Ophthalmology.
authors.forename: Jan A
authors.initials: JA
authors.lastname: Kylstra
authors.affiliation: Pathology and Laboratory Medicine, and.
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Ralston
authors.affiliation: Pathology and Laboratory Medicine, and.
authors.forename: Sally E
authors.initials: SE
authors.lastname: Self
authors.affiliation: Pediatric Rheumatology, Medical University of South Carolina, Charleston, South Carolina.
authors.forename: Natasha M
authors.initials: NM
authors.lastname: Ruth
authors.affiliation: Departments of Ophthalmology.
authors.forename: Lucian V
authors.initials: LV
authors.lastname: Del Priore
mesh_terms: D000293:Adolescent; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology*; D013956:Antithyroid Agents / Q000009:adverse effects; D001528:Behcet Syndrome / Q000139:chemically induced* / Q000150:complications / Q000276:immunology; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D008713:Methimazole / Q000009:adverse effects*; D012161:Retinal Artery / Q000473:pathology*; D031300:Retinal Vasculitis / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D014792:Visual Acuity
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D013956:Antithyroid Agents; D008713:Methimazole