title: A Paradox: α-Klotho Levels and Smoking Intensity.
abstract: Reports regarding smoking differences in α-klotho expression have provided conflicting results. In the current study we focused on the influence of smoking intensity to serum levels of the aging molecule α-klotho in healthy smokers. 40 middle aged healthy smokers without airway obstruction or restriction were selected for the analysis. Serum levels of soluble α-klotho were significantly higher in heavy smokers (P < 0.001). These results are in agreement with the possibility that α-klotho acts as anti-inflammatory molecule and strengthen the hypothesis that an increase of serum levels of α-klotho might be a compensatory response to smoking stress in healthy population.
authors.affiliation: Department of Biomedical Sciences, Universidad Europea, 28670, Villaviciosa de Odón, Madrid, Spain. zoraida.verde@universidadeuropea.es.
authors.forename: Zoraida
authors.initials: Z
authors.lastname: Verde
authors.affiliation: Department of Neumology, Hospital Gregorio Marañón, Madrid, Spain.
authors.forename: Jose M Rodríguez
authors.initials: JM
authors.lastname: González-Moro
authors.affiliation: Cátedra Complutense Diagnostic and Innovation, Universidad Complutense, Madrid, Spain.
authors.forename: Luis M
authors.initials: LM
authors.lastname: Chicharro
authors.affiliation: Department of Biomedical Sciences, Universidad Europea, 28670, Villaviciosa de Odón, Madrid, Spain.|Occupational Medicine, Grupo Banco Popular, Madrid, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Reinoso-Barbero
authors.affiliation: Department of Toxicology and Health Sanitary, Universidad Complutense, Madrid, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Bandrés
authors.affiliation: School of Doctoral Studies & Research, Universidad Europea, Madrid, Spain.
authors.forename: Félix
authors.initials: F
authors.lastname: Gómez-Gallego
authors.affiliation: School of Doctoral Studies & Research, Universidad Europea, Madrid, Spain.
authors.forename: Catalina
authors.initials: C
authors.lastname: Santiago
mesh_terms: D000328:Adult; D000073865:Cigarette Smoking / Q000097:blood* / Q000503:physiopathology; D005541:Forced Expiratory Volume; D005966:Glucuronidase / Q000097:blood*; D064368:Healthy Volunteers; D006801:Humans; D000090265:Klotho Proteins; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D062789:Tobacco Products / Q000706:statistics & numerical data*; D014797:Vital Capacity
chemical_list: D005966:Glucuronidase; D000090265:Klotho Proteins
keywords: Aging; Cigarettes per day; Healthy smokers; Packs year smoked; α-Klotho