title: MRI and serum biomarkers correlate with radiographic features in painful hand osteoarthritis.
abstract: OBJECTIVE
  To explore the relationship between clinical findings, biologic biomarkers, conventional radiography and MRI in patients with painful hand OA.
  
  
  METHODS
  The following patient baseline data from the DORA study (evaluating anti-TNF-α agents against painful hand OA) were used: clinical assessment (pain, swelling, stiffness and function: Dreiser functional hand index [FIHOA] and Cochin hand functional scale [CHFS]); measurement of biomarkers (cartilage oligomeric matrix protein (COMP), type IIA collagen N-propeptid (PIINP), hyaluronic acid (HA), ultrasensitive C-reactive protein (usCRP), tumour necrosis factor (TNF), interleukin (IL)-6, IL-1β and urinary CTXII); radiological staging (Verbruggen, Kallman, Kellgren-Lawrence); anatomical evaluation by contrast-enhanced MRI of proximal and distal interphalangeal joints of dominant hand. Associations between clinical, biomarker and imaging findings were assessed using the Spearman correlation coefficient and test.
  
  
  RESULTS
  18 patients were recruited, and 144 joints studied. A correlation was found between clinical features (pain, FIHOA, CHFS) and the Verbruggen score (respectively: p=0.05, r=0.47; p=0.05, r=0.48; p=0.05, r=0.48). Serum IL-1 level was strongly associated with loss of function (FIHOA: p=0.02, r=-0.73; CHFS: p=0.01, r=-0.76) and radiological erosions (p=0.03, r=0.7) as with urinary CTX2. A significant association was found between MRI osteophytes and usCRP (p=0.0026). MRI and radiological features were significantly correlated except for synovitis and bone marrow lesions.
  
  
  CONCLUSIONS
  MRI synovitis was not correlated with radiological scores, clinical or biologic markers of inflammation. There was a strong correlation between other MRI features and radiological scores. Serum IL-1 level was associated with structural damage and function.
authors.affiliation: Rheumatology Department, CHU Archet 1, LAMHESS EA6309, University of Nice Sophia Antipolis, France. roux.c2@chu-nice.fr.
authors.forename: Christian H
authors.initials: CH
authors.lastname: Roux
authors.affiliation: Rheumatology Department, University of Paris VI, CHU Pitié Salpétrière, Paris, France.
authors.forename: Violaine
authors.initials: V
authors.lastname: Foltz
authors.affiliation: Rheumatology Department, Saint Antoine Hospital, AP-HP, Paris, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Maheu
authors.affiliation: Epidemiology and Biostatistics Department, INSERM, U738, Bichat-Claude Bernard Hospital Group, Paris, France.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Baron
authors.affiliation: Rheumatology Department, University of Paris VI, CHU Pitié Salpétrière, Paris, France.
authors.forename: Frederique
authors.initials: F
authors.lastname: Gandjbakhch
authors.affiliation: Rheumatology Department, Lapeyronie Hospital, Montpellier, France.
authors.forename: Cédric
authors.initials: C
authors.lastname: Lukas
authors.affiliation: Rheumatology Department, CHRU Besançon, France.
authors.forename: Daniel
authors.initials: D
authors.lastname: Wendling
authors.affiliation: Rheumatology Department, CHU Nancy-Brabois, Nancy, France.
authors.forename: Damien
authors.initials: D
authors.lastname: Loeuille
authors.affiliation: Rheumatology Department South, CHU Sainte Marguerite, Marseille, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Lafforgue
authors.affiliation: Rheumatology Department, CHU Archet 1, LAMHESS EA6309, University of Nice Sophia Antipolis, France.
authors.forename: Liana
authors.initials: L
authors.lastname: Euler-Ziegler
authors.affiliation: Rheumatology Department, Lariboisiére Hospital, Paris, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Richette
authors.affiliation: Rheumatology Department, Henri Mondor Hospital, Creteil, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Chevalier
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D064236:Cartilage Oligomeric Matrix Protein / Q000097:blood; D005260:Female; D050823:Hand Joints / Q000000981:diagnostic imaging*; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D007375:Interleukin-1 / Q000097:blood; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000097:blood / Q000000981:diagnostic imaging*; D012720:Severity of Illness Index; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015415:Biomarkers; D064236:Cartilage Oligomeric Matrix Protein; D007375:Interleukin-1; D053583:Interleukin-1beta; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D006820:Hyaluronic Acid; D002097:C-Reactive Protein