title: Impact of restless legs syndrome in patients with inflammatory bowel disease on sleep, fatigue, and quality of life.
abstract: OBJECTIVE
  Inflammatory bowel disease has been associated with neurological symptoms including restless legs syndrome. Here, we investigated the impact of restless legs syndrome in patients with inflammatory bowel disease on sleep, fatigue, mood, cognition, and quality of life.
  
  
  METHODS
  Two groups of inflammatory bowel disease patients, with and without restless legs syndrome, were prospectively evaluated for sleep disorders, fatigue, daytime sleepiness, depression, anxiety, and health-related quality of life. Furthermore, global cognitive function, executive function, attention, and concentration were assessed in both groups. Disease activity and duration of inflammatory bowel disease as well as current medication were assessed by interview. Inflammatory bowel disease patients with and without restless legs syndrome were matched for age, education, severity, and duration of their inflammatory bowel disease.
  
  
  RESULTS
  Patients with inflammatory bowel disease and clinically relevant restless leg syndrome suffered significantly more frequent from sleep disturbances including sleep latency and duration, more fatigue, and worse health-related quality of life as compared to inflammatory bowel disease patients without restless legs syndrome. Affect and cognitive function including cognitive flexibility, attention, and concentration showed no significant differences among groups, indicating to be not related to restless legs syndrome.
  
  
  CONCLUSIONS
  Sleep disorders including longer sleep latency, shorter sleep duration, and fatigue are characteristic symptoms of restless legs syndrome in inflammatory bowel disease patients, resulting in worse health-related quality of life. Therefore, clinicians treating patients with inflammatory bowel disease should be alert for restless legs syndrome.
authors.affiliation: Department of Neurology, Charité-Universitätsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany. KSchindl@northwell.edu.
authors.forename: Katharina A
authors.initials: KA
authors.lastname: Schindlbeck
authors.affiliation: Department of Medicine I (Gastroenterology, Infectious Diseases, Rheumatology), Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Janek
authors.initials: J
authors.lastname: Becker
authors.affiliation: Department of Medicine I (Gastroenterology, Infectious Diseases, Rheumatology), Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Felix
authors.initials: F
authors.lastname: Berger
authors.affiliation: Department of Neurology, Charité-Universitätsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany.
authors.forename: Arne
authors.initials: A
authors.lastname: Mehl
authors.affiliation: Department of Neurology, Charité-Universitätsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Rewitzer
authors.affiliation: Department of Neurology, Charité-Universitätsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany.
authors.forename: Sarah
authors.initials: S
authors.lastname: Geffe
authors.affiliation: Department of Neurology, Charité-Universitätsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany.
authors.forename: Peter M
authors.initials: PM
authors.lastname: Koch
authors.affiliation: Department of Medicine I (Gastroenterology, Infectious Diseases, Rheumatology), Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Jan C
authors.initials: JC
authors.lastname: Preiß
authors.affiliation: Department of Medicine I (Gastroenterology, Infectious Diseases, Rheumatology), Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Britta
authors.initials: B
authors.lastname: Siegmund
authors.affiliation: Department of Medicine I (Gastroenterology, Infectious Diseases, Rheumatology), Charité-Universitätsmedizin Berlin, Berlin, Germany.|Gastroenterologie am Bayerischen Platz, Berlin, Germany.
authors.forename: Jochen
authors.initials: J
authors.lastname: Maul
authors.affiliation: Department of Neurology, Charité-Universitätsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Marzinzik
mesh_terms: D003710:Demography; D005221:Fatigue / Q000150:complications* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications* / Q000503:physiopathology* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012148:Restless Legs Syndrome / Q000150:complications* / Q000503:physiopathology* / Q000523:psychology; D012890:Sleep
keywords: Inflammatory bowel disease; Quality of life; Restless legs syndrome