title: Thrombelastography coagulation index may be a predictor of venous thromboembolism in gynecological oncology patients.
abstract: OBJECTIVE
  Venous thromboembolism (VTE) is a well-recognized complication in gynecological oncology patients, and has an impact on the overall outcome. The purpose of this study was to identify whether thrombelastography (TEG) predicts VTE in gynecological oncology patients.
  
  
  METHODS
  This retrospective study included patients with gynecological oncology who were hospitalized at the Fujian Provincial Cancer Hospital from May 2014 to April 2016. Univariate and logistic regression multivariate analyses were performed to determine the clinical and laboratorial factors for VTE in gynecological oncology patients. The sensitivity and specificity of predictors was calculated using receiver operating characteristic curve.
  
  
  RESULTS
  The study included 376 patients; 39 (10.37%) developed VTE. Logistic regression multivariate analysis revealed that TEG coagulation index (CI) value, D-dimer, arrhythmia, coronary heart disease, surgery within four weeks and chemotherapy within four weeks were independent risk factors for VTE. The area under the curve values were 0.71 (95% confidence interval 0.63-0.79, P = 0.000) for TEG CI and 0.67 (95% confidence interval 0.58-0.76, P = 0.000) for D-Dimer. The TEG CI cut-off value was 2.55, which had 53.8% sensitivity and 75.4% specificity for VTE.
  
  
  CONCLUSIONS
  These results indicated that the TEG CI value may be predictive of VTE in gynecological oncology patients.
authors.affiliation: Department of Blood Transfusion, Fujian Provincial Cancer Hospital, Teaching Hospital of Fujian Medical University, Fuzhou, China.
authors.forename: Jingfu
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Blood Transfusion, Fujian Provincial Cancer Hospital, Teaching Hospital of Fujian Medical University, Fuzhou, China.
authors.forename: Na
authors.initials: N
authors.lastname: Wang
authors.affiliation: Department of Blood Transfusion, Fujian Provincial Cancer Hospital, Teaching Hospital of Fujian Medical University, Fuzhou, China.
authors.forename: Yujuan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Blood Transfusion, Fujian Provincial Cancer Hospital, Teaching Hospital of Fujian Medical University, Fuzhou, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Lu
authors.affiliation: Department of Blood Transfusion, Fujian Provincial Cancer Hospital, Teaching Hospital of Fujian Medical University, Fuzhou, China.
authors.forename: Xianren
authors.initials: X
authors.lastname: Ye
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005833:Genital Neoplasms, Female / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D012307:Risk Factors; D013916:Thrombelastography; D054556:Venous Thromboembolism / Q000150:complications / Q000175:diagnosis*; D055815:Young Adult
keywords: gynecological oncology; ovarial neoplasms; thrombelastography; uterine cervical neoplasms; venous thromboembolism