title: Equilibrative nucleoside transporters-A review.
abstract: Equilibrative nucleoside transporters (ENTs) are polytopic integral membrane proteins that mediate the transport of nucleosides, nucleobases, and therapeutic analogs. The best-characterized ENTs are the human transporters hENT1 and hENT2. However, non-mammalian eukaryotic ENTs have also been studied (e.g., yeast, parasitic protozoa). ENTs are major pharmaceutical targets responsible for modulating the efficacy of more than 30 approved drugs. However, the molecular mechanisms and chemical determinants of ENT-mediated substrate recognition, binding, inhibition, and transport are poorly understood. This review highlights findings on the characterization of ENTs by surveying studies on genetics, permeant and inhibitor interactions, mutagenesis, and structural models of ENT function.
authors.affiliation: a Department of Biochemistry and Molecular Biology , University of Oklahoma Health Sciences Center , Oklahoma City , OK , USA.
authors.forename: Rebba C
authors.initials: RC
authors.lastname: Boswell-Casteel
authors.affiliation: a Department of Biochemistry and Molecular Biology , University of Oklahoma Health Sciences Center , Oklahoma City , OK , USA.|b Stephenson Cancer Center , University of Oklahoma Health Sciences Center , Oklahoma City , OK , USA.|c Harold Hamm Diabetes Center , University of Oklahoma Health Sciences Center , Oklahoma City , OK , USA.
authors.forename: Franklin A
authors.initials: FA
authors.lastname: Hays
mesh_terms: D000818:Animals; D033721:Equilibrative Nucleoside Transporter 1 / Q000378:metabolism; D055786:Gene Knockout Techniques; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods; D016296:Mutagenesis; D009369:Neoplasms / Q000378:metabolism / Q000401:mortality; D033703:Nucleoside Transport Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide; D015800:Protozoan Proteins / Q000378:metabolism
chemical_list: D033721:Equilibrative Nucleoside Transporter 1; C411852:LdNT2 protein, Leishmania donovani; D033703:Nucleoside Transport Proteins; D015800:Protozoan Proteins; C438649:SLC29A1 protein, human
keywords: Nucleoside transport; equilibrative nucleoside transporter; membrane protein; nucleobase transport