title: Diagnostic and prognostic significance of E-cadherin and Ki-67 expression in non-small cell lung cancer patients.
abstract: To elucidate the relationship between E-cadherin (E-cad) and Ki-67, and to determine their clinical significance in non-small cell lung cancer (NSCLC).
  
  
  
  A total of 68 NSCLC paraffin embedded tissue specimens and tumor-adjacent normal tissue specimens were collected. The expression of E-cad and Ki-67 was examined by immunohistochemistry and the relationships between the expression of these two markers were evaluated. The clinicopathological features were correlated with the expression of E-cad and Ki-67 to check whether these proteins have any association and if exist an association whether E-cad and Ki-67 can be used in diagnosis and prognosis of NSCLSC.
  
  
  
  E-cad was expressed in all the normal tissues but Ki-67 expressed in only 5.8% of normal tissues. Ki-67 and E-cad expression were observed in 61.8% and 25% of NSCLC tissues respectively. Correlation analysis revealed an inverse association between the expression of E-cad and Ki-67 (r = 0.524, p = 0.000). The clinicopathological features such as tumor differentiation, TNM stage, lymph node metastasis and pleural invasion were all significantly associated with E-cad and Ki-67 expression (p < 0.05).
  
  
  
  E-cad and Ki-67 together play a key role in the development, invasion and metastasis of NSCLC and combined detection of them serve as a potential marker for clinical diagnosis in addition to exploiting them as a therapeutic target.
authors.affiliation: Departments of fifth Oncology, Hebei People's Hospital, Shijiazhuang, Hebei, P.R. China. 1256596529@qq.com.
authors.forename: L-Y
authors.initials: LY
authors.lastname: He
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.forename: Z K
authors.initials: ZK
authors.lastname: Wang
authors.forename: H-Z
authors.initials: HZ
authors.lastname: Zhang
mesh_terms: D015703:Antigens, CD; D015820:Cadherins / Q000096:biosynthesis*; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D006801:Humans; D019394:Ki-67 Antigen; D008175:Lung Neoplasms / Q000235:genetics*; D011379:Prognosis
chemical_list: D015703:Antigens, CD; C513384:CDH1 protein, human; D015820:Cadherins; D019394:Ki-67 Antigen