title: Increased Proliferative Activity Accompanies the Local Inflammatory Response of Gastric Mucosa After Intragastric Balloon Insertion.
abstract: The use of BioEnterics intragastric balloon (BIB) is progressively increasing, owing to the fact that morbid obesity becomes a global epidemic together with risks of bariatric surgery. Yet, the possible local BIB effect on gastric mucosa is not clearly elucidated. The aim of the current study was to assess the histological changes occurring in the gastric mucosa post-BIB insertion.
  
  
  
  Gastric mucosa biopsy was obtained from 87 cases of morbid obesity both pre-BIB and 6 months post-BIB insertion to compare the local changes by histological and immunohistochemical analysis.
  
  
  
  An inflammatory reaction was detected in the post-BIB mucosa which displayed a positive CD20, CD3 (p < 0.05), and the proliferation index (Ki67) increased significantly compared with that of the pre-BIB cases. The Ki67 index showed a significant positive correlation with CD20 and CD3 immunoexpression in the post-BIB gastric mucosae.
  
  
  
  Our results demonstrated a possible increase in the gastric proliferative activity after BIB insertion accompanied with a remarkable local inflammatory reaction. Although these findings may be reactive and transient, endoscopic follow-up is recommended for early detection of further pathological changes.
authors.affiliation: Gastroenterology Surgical Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
authors.forename: Ehab
authors.initials: E
authors.lastname: Atef
authors.affiliation: Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
authors.forename: Khaled Refaat
authors.initials: KR
authors.lastname: Zalata
authors.affiliation: Department of Histology and Cell Biology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
authors.forename: Hoda
authors.initials: H
authors.lastname: Atef
authors.affiliation: Department of Histology and Cell Biology, Faculty of Medicine, Mansoura University, Mansoura, Egypt. profahmadpasha@mans.edu.eg.
authors.forename: Ahmed A M
authors.initials: AA
authors.lastname: Abdel-Hamid
mesh_terms: D000328:Adult; D018951:Antigens, CD20 / Q000276:immunology*; D050110:Bariatric Surgery; D017252:CD3 Complex / Q000276:immunology*; D049109:Cell Proliferation; D005260:Female; D015905:Gastric Balloon; D005753:Gastric Mucosa / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000601:surgery*; D011706:Pyloric Antrum / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D012189:Retrospective Studies
chemical_list: D018951:Antigens, CD20; D017252:CD3 Complex; D019394:Ki-67 Antigen
keywords: BioEnterics intragastric balloon; CD20 expression; CD3 expression; Gastric mucosa; Ki67 proliferative marker; Local inflammatory reaction; Morbid obesity