title: Volumetric analysis of the cerebellum in patients with progressive supranuclear palsy.
abstract: Although early cerebellar symptoms are one of the exclusive criteria in the diagnosis of progressive supranuclear palsy (PSP), cerebellar involvement in PSP is evident both clinically and pathologically. However, structural analysis focusing on the cerebellum has not been previously studied in patients with PSP. We aimed to evaluate cerebellar involvement in PSP using a magnetic resonance imaging-based segmental volumetric analysis.
  
  
  
  We retrospectively enrolled 48 patients with PSP composed of 25 patients with PSP-Richardson's syndrome (RS) and 23 patients with pure akinesia with gait freezing, 39 patients with Parkinson's disease (PD) and 34 healthy controls. Data on both the whole and segmented cerebellar volumes were analyzed using a fully automated procedure.
  
  
  
  A general linear model showed that whole cerebellar volume in patients with PSP was significantly smaller compared with that of patients with PD or controls after controlling for age, sex and intracranial volume (P = 0.34). In addition, patients with PSP exhibited decreased regional volume in the crus I, lobule VIIIa and lobule VIIIb, which play roles as secondary representations of motor tasks, compared with patients with PD or controls. In subgroup analysis of PSP, volume loss in the whole and segmental cerebellum was more pronounced in patients with PSP-RS than in those with pure akinesia with gait freezing, PD or control subjects.
  
  
  
  These data demonstrate that cerebellar atrophy is evident in patients with PSP and is especially prominent in the PSP-RS group. These findings increase understanding of the clinicopathological basis of cerebellar involvement in PSP.
authors.affiliation: Department of Neurology, Yonsei University College of Medicine, Seoul.
authors.forename: Y
authors.initials: Y
authors.lastname: Lee
authors.affiliation: Department of Biomedical Engineering, Hanyang University, Seoul.
authors.forename: D K
authors.initials: DK
authors.lastname: Lee
authors.affiliation: Department of Biomedical Engineering, Hanyang University, Seoul.
authors.forename: J M
authors.initials: JM
authors.lastname: Lee
authors.affiliation: Department of Neurology, Yonsei University College of Medicine, Seoul.
authors.forename: S J
authors.initials: SJ
authors.lastname: Chung
authors.affiliation: Department of Neurology, Inje University College of Medicine, Ilsan Paik Hospital, Goyang.
authors.forename: J J
authors.initials: JJ
authors.lastname: Lee
authors.affiliation: Department of Neurology, Yonsei University College of Medicine, Seoul.
authors.forename: Y H
authors.initials: YH
authors.lastname: Sohn
authors.affiliation: Department of Neurology, Yonsei University College of Medicine, Seoul.|Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: P H
authors.initials: PH
authors.lastname: Lee
mesh_terms: D000368:Aged; D002531:Cerebellum / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009929:Organ Size / Q000502:physiology; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000473:pathology; D012189:Retrospective Studies; D013494:Supranuclear Palsy, Progressive / Q000000981:diagnostic imaging / Q000473:pathology*
keywords: atrophy; cerebellum; progressive supranuclear palsy; volumetry