title: Risk Factors for Adverse Drug Reactions in Older Subjects Hospitalized in a Dedicated Dementia Unit.
abstract: OBJECTIVE
  To identify risk factors for the occurrence of adverse drug reactions (ADRs) based on geriatric evaluation.
  
  
  METHODS
  Longitudinal prospective study from May 2010 to November 2011.
  
  
  METHODS
  Dedicated acute geriatric care unit specializing in the management of patients with dementia syndrome (Alzheimer disease or related syndromes) at the University Hospital of Reims, France.
  
  
  METHODS
  Older patients with dementia syndrome (Alzheimer disease or related syndromes).
  
  
  METHODS
  Sociodemographic variables and comprehensive geriatric assessment were recorded. Occurrence of ADRs was noted. Risk factors for ADR were identified by multivariate logistic regression.
  
  
  RESULTS
  During the study period, 293 patients were included; average age was 82 ± 8 years; the majority were women (61.4%). Average Mini-Mental State Examination score was 13 ± 8; average activities of daily living (ADL) score was 3.6 ± 2.1. Independent risk factors for occurrence of at least one ADR were polypharmacy (≥5 drugs/day) (OR: 4.0, 95% CI: 1.1-14.1) and dependence on at least 1 ADL (OR: 2.6, 95% CI: 1.1-6.5).
  
  
  CONCLUSIONS
  Risk factors for ADRs were polypharmacy and dependence on at least one ADL. Our findings underline the importance of taking into consideration the characteristics of the patients when prescribing drugs in this specific population. Prescriptions should be re-evaluated at each follow-up.
authors.affiliation: Department of Research and Innovation, Reims University Hospital, Reims, France.
authors.forename: Lukshe
authors.initials: L
authors.lastname: Kanagaratnam
authors.affiliation: Department of Research and Innovation, Reims University Hospital, Reims, France; Faculty of Medicine, University of Reims Champagne-Ardenne, Reims, France. Electronic address: mdrame@chu-reims.fr.
authors.forename: Moustapha
authors.initials: M
authors.lastname: Dramé
authors.affiliation: Department of Geriatrics and Internal Medicine, Reims University Hospital, Reims, France; Faculty of Medicine, University of Reims Champagne-Ardenne, Reims, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Novella
authors.affiliation: Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Reims University Hospital, Reims, France; Faculty of Medicine, University of Reims Champagne-Ardenne, Reims, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Trenque
authors.affiliation: Department of Research and Innovation, Reims University Hospital, Reims, France.
authors.forename: Clarisse
authors.initials: C
authors.lastname: Joachim
authors.affiliation: Department of Cardiology, Reims University Hospital, Reims, France; Faculty of Medicine, University of Reims Champagne-Ardenne, Reims, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Nazeyrollas
authors.affiliation: Department of Research and Innovation, Reims University Hospital, Reims, France; Faculty of Medicine, University of Reims Champagne-Ardenne, Reims, France.
authors.forename: Damien
authors.initials: D
authors.lastname: Jolly
authors.affiliation: Department of Geriatrics and Internal Medicine, Reims University Hospital, Reims, France; Faculty of Medicine, University of Reims Champagne-Ardenne, Reims, France.
authors.forename: Rachid
authors.initials: R
authors.lastname: Mahmoudi
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D003704:Dementia / Q000453:epidemiology*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology*; D005260:Female; D005602:France / Q000453:epidemiology; D015577:Geriatric Assessment; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D000073216:Mental Status and Dementia Tests; D019338:Polypharmacy; D011446:Prospective Studies; D012307:Risk Factors
keywords: adverse drug reaction; dementia syndrome; older subject; polypharmacy