title: Effective uric acid-lowering treatment for hypertensive patients with hyperuricemia.
abstract: Uric acid (UA) has been associated with hypertension, renal disease and cardiovascular disease. The aim of the present study was to compare the UA-lowering effects of a standard dose of the UA synthesis inhibitor febuxostat to a standard dose of the uricosuric agent benzbromarone, and to investigate the effects of a low-dose combination of both agents in hypertensive patients with hyperuricemia. Twenty hypertensive patients with inadequate UA control were administered febuxostat 40 mg (Feb), benzbromarone 50 mg (Ben) and febuxostat 20 mg and benzbromarone 25 mg (feb/ben) for 3 months each in a randomized modified crossover manner. UA metabolism, blood pressure (BP) and the indices of organ damage were assessed at baseline and the end of each treatment period. No significant changes were observed in BP or estimated glomerular filtration rate (eGFR) after the treatment with each UA-lowering regimen. The change in UA was significantly greater with feb/ben than with Feb. The excretion of UA and clearance of UA were higher with Ben than with Feb and feb/ben. Urinary 8-hydroxydeoxyguanosine and liver-type fatty-acid-binding protein levels were slightly lower with Ben, whereas flow-mediated dilation was slightly higher with feb/ben and Ben. The UA-lowering effects of the low-dose combination of the UA synthesis inhibitor and uricosuric agent were greater than those of the standard dose of each agent alone. The uricosuric agent may be more effective at improving vascular function than the UA synthesis inhibitor. Thus, the appropriate management of hyperuricemia with uricosuric drugs appears to be useful for hypertensive patients with hyperuricemia.
authors.affiliation: Division of Hypertension and Nephrology, National Cerebral and Cardiovascular Center, Osaka, Japan.|Division of Internal Medicine, Kuroda Orthopedic Hospital, Fukuoka, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Ohta
authors.affiliation: Division of Hypertension and Nephrology, National Cerebral and Cardiovascular Center, Osaka, Japan.
authors.forename: Azusa
authors.initials: A
authors.lastname: Ishizuka
authors.affiliation: Center for Epidemiological Research in Asia, Shiga University of Medical Science, Shiga, Japan.
authors.forename: Hisatomi
authors.initials: H
authors.lastname: Arima
authors.affiliation: Division of Hypertension and Nephrology, National Cerebral and Cardiovascular Center, Osaka, Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Hayashi
authors.affiliation: Division of Hypertension and Nephrology, National Cerebral and Cardiovascular Center, Osaka, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Iwashima
authors.affiliation: Division of Hypertension and Nephrology, National Cerebral and Cardiovascular Center, Osaka, Japan.
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Kishida
authors.affiliation: Division of Hypertension and Nephrology, National Cerebral and Cardiovascular Center, Osaka, Japan.
authors.forename: Fumiki
authors.initials: F
authors.lastname: Yoshihara
authors.affiliation: Division of Hypertension and Nephrology, National Cerebral and Cardiovascular Center, Osaka, Japan.
authors.forename: Satoko
authors.initials: S
authors.lastname: Nakamura
authors.affiliation: Division of Hypertension and Nephrology, National Cerebral and Cardiovascular Center, Osaka, Japan.|Department of Medical Technology, Teikyo University Fukuoka, Fukuoka, Japan.
authors.forename: Yuhei
authors.initials: Y
authors.lastname: Kawano
mesh_terms: D000368:Aged; D001553:Benzbromarone / Q000627:therapeutic use*; D018592:Cross-Over Studies; D004359:Drug Therapy, Combination; D000069465:Febuxostat / Q000627:therapeutic use*; D005260:Female; D006074:Gout Suppressants / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications*; D033461:Hyperuricemia / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014527:Uric Acid / Q000097:blood*
chemical_list: D006074:Gout Suppressants; D000069465:Febuxostat; D014527:Uric Acid; D001553:Benzbromarone