title: Placental Elasticity and Histopathological Findings in Normal and Intra-Uterine Growth Restriction Pregnancies Assessed with Strain Elastography in Ex Vivo Placenta.
abstract: The aim of this study was to investigate the differences of placental elasticity between intra-uterine growth restriction (IUGR) and normal pregnancies to show whether or not there is any association between histopathological changes and placental elasticity. Fifty-five human placentas were collected at delivery, including 25 with IUGR and 30 controls. Strain elastography (SE) was performed ex vivo and all placentas were examined histopathologically. Elasticity index (EI) and histopathological findings were compared between groups. The placental stiffness and presence of histopathological changes were higher in the IUGR group than in controls (p < 0.05). Also, histopathological findings were associated with decreased EI values, but no specific patterns of histologic abnormalities were identified except villitis and delayed villous maturity. Distinct reduced placental elasticity could be the result of the cumulative effects of all the histologic findings in IUGR.
authors.affiliation: Department of Radiology, Ministry of Health Ankara Training and Research Hospital, Ankara, Turkey. Electronic address: gamzedurhan@gmail.com.
authors.forename: Gamze
authors.initials: G
authors.lastname: Durhan
authors.affiliation: Department of Pathology, Ministry of Health Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Hatice
authors.initials: H
authors.lastname: Ünverdi
authors.affiliation: Department of Obstetrics and Gynecology, Ministry of Health Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Canan
authors.initials: C
authors.lastname: Deveci
authors.affiliation: Department of Radiology, Ministry of Health Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Büyükşireci
authors.affiliation: Department of Biostatistics, Hacettepe University, Ankara, Turkey.
authors.forename: Jale
authors.initials: J
authors.lastname: Karakaya
authors.affiliation: Department of Radiology, Ministry of Health Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Tülin
authors.initials: T
authors.lastname: Değirmenci
authors.affiliation: Department of Radiology, Ministry of Health Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Bayrak
authors.affiliation: Department of Radiology, Ministry of Health Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Pınar
authors.initials: P
authors.lastname: Koşar
authors.affiliation: Department of Pathology, Ministry of Health Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Sema
authors.initials: S
authors.lastname: Hücümenoğlu
authors.affiliation: Department of Obstetrics and Gynecology, Ministry of Health Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Ergün
mesh_terms: D000293:Adolescent; D000328:Adult; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging*; D006801:Humans; D010920:Placenta / Q000000981:diagnostic imaging* / Q000473:pathology*; D010922:Placenta Diseases / Q000000981:diagnostic imaging*; D011247:Pregnancy; D055815:Young Adult
keywords: Intra-uterine growth restriction; Placental elasticity; Placental histopathology; Strain elastography