title: Two Cases of Hemicrania Continua-Trigeminal Neuralgia Syndrome: Expanding the Spectrum of Trigeminal Autonomic Cephalalgia-Tic (TAC-TIC) Syndrome.
abstract: BACKGROUND
  Trigeminal neuralgia (TN) has been described in association with various primary headache disorders. So far, no case of TN has been reported in association with hemicrania continua (HC).
  
  
  METHODS
  Here, we report two patients of hemicrania continua associated with TN (HC-tic syndrome). These patients had both headaches concurrently. Both patients responded to a combination of carbamazepine and indomethacin. The skipping or tapering of carbamazepine led to the recurrence of the neuralgic pain of TN. In the same way, the skipping of indomethacin resulted in the relapse of the pain, typical of HC.
  
  
  CONCLUSIONS
  With these two cases of HC-tic syndrome, we suggest that TN has a special predilection for all types of TACs. Various speculations suggest that such associations are more than a simple coincidence, and both diseases may be causally interrelated. The identification of this association is important as both disorders may need separate drugs.
authors.affiliation: Department of Neurology, Smt. B. K. Shah Medical Institute and Research Centre, Sumandeep Vidyapeeth University, Piparia, Baroda, Gujarat, 3901760, India.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Prakash
authors.affiliation: Department of Neurology, Smt. B. K. Shah Medical Institute and Research Centre, Sumandeep Vidyapeeth University, Piparia, Baroda, Gujarat, 3901760, India.
authors.forename: Chaturbhuj
authors.initials: C
authors.lastname: Rathore
mesh_terms: D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002220:Carbamazepine / Q000627:therapeutic use; D018450:Disease Progression; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D051303:Trigeminal Autonomic Cephalalgias / Q000188:drug therapy / Q000209:etiology*; D014277:Trigeminal Neuralgia / Q000150:complications* / Q000188:drug therapy
chemical_list: D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002220:Carbamazepine; D007213:Indomethacin
keywords: hemicrania continua; indomethacin; trigeminal autonomic cephalalgias; trigeminal neuralgia