title: Distinct Roles of Parvalbumin- and Somatostatin-Expressing Interneurons in Working Memory.
abstract: Inhibitory interneurons are thought to play crucial roles in diverse brain functions. However, roles of different inhibitory interneuron subtypes in working memory remain unclear. We found distinct activity patterns and stimulation effects of two major interneuron subtypes, parvalbumin (PV)- and somatostatin (SOM)-expressing interneurons, in the medial prefrontal cortex of mice performing a spatial working memory task. PV interneurons showed weak target-dependent delay-period activity and were strongly inhibited by reward. By contrast, SOM interneurons showed strong target-dependent delay-period activity, and only a subtype of them was inhibited by reward. Furthermore, optogenetic stimulation of PV and SOM interneurons preferentially suppressed discharges of putative pyramidal cells and interneurons, respectively. These results indicate different contributions of PV and SOM interneurons to prefrontal cortical circuit dynamics underlying working memory.
authors.affiliation: Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.
authors.forename: Dohoung
authors.initials: D
authors.lastname: Kim
authors.affiliation: Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.
authors.forename: Huijeong
authors.initials: H
authors.lastname: Jeong
authors.affiliation: Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.
authors.forename: Juhyeong
authors.initials: J
authors.lastname: Lee
authors.affiliation: Center for Synaptic Brain Dysfunctions, Institute for Basic Science, Daejeon 34141, Korea.
authors.forename: Jeong-Wook
authors.initials: JW
authors.lastname: Ghim
authors.affiliation: Center for Synaptic Brain Dysfunctions, Institute for Basic Science, Daejeon 34141, Korea.
authors.forename: Eun Sil
authors.initials: ES
authors.lastname: Her
authors.affiliation: Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.
authors.forename: Seung-Hee
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea; Center for Synaptic Brain Dysfunctions, Institute for Basic Science, Daejeon 34141, Korea. Electronic address: mwjung@kaist.ac.kr.
authors.forename: Min Whan
authors.initials: MW
authors.lastname: Jung
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D055879:Gene Knock-In Techniques; D007395:Interneurons / Q000378:metabolism / Q000502:physiology*; D008570:Memory, Short-Term / Q000502:physiology*; D051379:Mice; D062308:Optogenetics; D010320:Parvalbumins / Q000235:genetics / Q000378:metabolism; D017397:Prefrontal Cortex / Q000502:physiology*; D017966:Pyramidal Cells / Q000502:physiology*; D012201:Reward; D013004:Somatostatin / Q000235:genetics / Q000378:metabolism
chemical_list: D010320:Parvalbumins; D013004:Somatostatin
keywords: animal; interneuron; mice; optogenetics; parvalbumin; physiology; prefrontal cortex; reward; somatostatin; working memory