title: Synthesis and biological activity of the novel indanedione anticoagulant rodenticides containing fluorine.
abstract: Here, 3 fluorinated intermediates of drug were synthesized: (M1), (M2), (M3). Three new anticoagulant rodenticides were designed which were based on 4-hydroxycoumarin or 1,3-indandione, added acute toxicity groups containing fluorine. The structures of synthesized compounds were analyzed and proved by FT-IR spectroscopy and1H nuclear magnetic resonance (1H-NMR). The compounds were also evaluated for their anticoagulant and acute biologic activity. In addition, both the acute orally toxicity and the feeding indexes of R1and R2were tested. The result of the experiment proved that the new synthesis of 1, 3 - indan diketone for maternal new anticoagulant rodenticide can replace the current 4 - hydroxyl coumarin as the mother of the second generation anticoagulant rodenticide and 1, 3 - indan diketone for maternal new anticoagulant rodenticides will have a good development prospect.
authors.affiliation: a Department of Chemistry , Northeastern University , Shenyang City , People's Republic of China.
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.affiliation: a Department of Chemistry , Northeastern University , Shenyang City , People's Republic of China.
authors.forename: Liping
authors.initials: L
authors.lastname: Liu
authors.affiliation: a Department of Chemistry , Northeastern University , Shenyang City , People's Republic of China.
authors.forename: Zengguo
authors.initials: Z
authors.lastname: Bai
authors.affiliation: a Department of Chemistry , Northeastern University , Shenyang City , People's Republic of China.
authors.forename: Tianhua
authors.initials: T
authors.lastname: Zhang
authors.affiliation: a Department of Chemistry , Northeastern University , Shenyang City , People's Republic of China.
authors.forename: Keke
authors.initials: K
authors.lastname: Zhao
mesh_terms: D015110:4-Hydroxycoumarins / Q000737:chemistry / Q000633:toxicity; D000818:Animals; D000925:Anticoagulants / Q000737:chemistry* / Q000633:toxicity; D001681:Biological Assay; D005260:Female; D005461:Fluorine / Q000737:chemistry* / Q000633:toxicity; D007189:Indans / Q000737:chemistry* / Q000633:toxicity; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D012378:Rodenticides / Q000737:chemistry* / Q000633:toxicity; D017550:Spectroscopy, Fourier Transform Infrared; D023382:Toxicity Tests, Acute
chemical_list: C413384:1,2-indanedione; D015110:4-Hydroxycoumarins; D000925:Anticoagulants; D007189:Indans; D012378:Rodenticides; D005461:Fluorine; C001445:1,3-indandione; C068805:4-hydroxycoumarin
keywords: 1,3-indandione; 4-hydroxycoumarin; One-bromo-2-fluoroethane; anti-coagulant rodenticid; chalcone; fluoroacetylchloride