title: Analysis of the association between glucose profiles and β-cell function for diabetic cardiovascular autonomic neuropathy in China.
abstract: OBJECTIVE
  The purpose of the present study was to investigate the severity of glucose profiles and β-cell function associated with diabetic cardiovascular autonomic neuropathy (DCAN) in a Chinese sample.
  
  
  METHODS
  A community-based, cross-sectional study to analyze the risk factors of DCAN was carried out with 455 individuals recruited from a Chinese population. The glucose profile risk score was calculated to identify the association between the severity of the glucose profiles and DCAN. The associations of the severity of the glucose profiles and β-cell function with DCAN were analyzed using multivariable logistic regression.
  
  
  RESULTS
  Univariate analysis showed that the glucose profiles and homeostatic model assessment of insulin resistance were significantly associated with the DCAN outcome, respectively. Multivariable logistic regression showed that significant associations exist between glucose profile indices and DCAN, after controlling for potential confounding factors (P < 0.01 for all) in both models. Multivariable logistic regression also showed that parameters of β-cell function were associated with the DCAN outcome in the category model (P < 0.1 for all). The glucose profile risk score was independently and significantly associated with the DCAN outcome after controlling for confounding factors (P < 0.001 and P for a trend <0.001).
  
  
  CONCLUSIONS
  Our observations suggest that parameters of glucose profile indices and β-cell function are significantly and independently associated with DCAN, respectively. There was a tendency toward increased glucose profile risk score with increasing prevalence of DCAN.
authors.affiliation: Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China.|Department of Endocrinology, Shanghai Tongji Hospital, Tongji University, Shanghai, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Fang
authors.affiliation: Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China.|Institutes of Integrative Medicine, Fudan University, Shanghai, China.
authors.forename: Jingcheng
authors.initials: J
authors.lastname: Dong
authors.affiliation: Department of Endocrinology and Metabolism, Fudan University Huashan Hospital, Shanghai, China.
authors.forename: Fangfang
authors.initials: F
authors.lastname: Zeng
authors.affiliation: Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China.|Institutes of Integrative Medicine, Fudan University, Shanghai, China.
authors.forename: Zihui
authors.initials: Z
authors.lastname: Tang
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003929:Diabetic Neuropathies / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D001786:Blood Glucose
keywords: Diabetic cardiovascular autonomic neuropathy; Glucose profile; β-Cell function