title: Organ Donation and Transplantation From Donors With Systemic Infection: A Single-Center Experience.
abstract: OBJECTIVE
  Donors with bacteremia and sepsis are often considered to be controversial for organ retrieval due to potential transmission of an infectious agent to the recipient. Herein we report our initial experience of organ donation and transplantation results from donors with systemic infection.
  
  
  METHODS
  From January 2013 to December 2014, 125 cases of donation were completed in our organ procurement organization including 90 cases of donation after brain death (DBD) and 35 cases of donation after circulatory death (DCD). The results of bacterial culture of the donor's peripheral venous blood (PVB), blood from central venous catheter (BCVC), urine, bronchial aspiration, and tip of central venous catheter (TCVC; Maki's semiquantitative culture) were retrospectively reviewed. All liver transplant recipients received specific antibiotics according the susceptibility profiles of the PVB cultures, and all kidney transplant recipients received specific antibiotics according the susceptibility profiles of the PVB and urine cultures. Bacterial infection diseases transmission from donors of the liver and kidney transplant recipients were also retrospectively reviewed.
  
  
  RESULTS
  The positive rates of the bacterial culture of the donor's bronchial aspiration, PVB, BCVC, TCVC, and urine were 46.4% (39/84), 20.2% (24/119), 15.8% (12/76), 11.1% (3/27), and 7.0% (8/115), respectively. Only 28.1% (9/32) of donors with positive cultures of PVB or urine received specific antimicrobial therapy before harvesting. Twenty-two livers and 46 kidneys from donors with systemic infection (positive PVB culture) were transplanted, and no case of bacterial infection diseases transmission occurred in the recipients.
  
  
  CONCLUSIONS
  In the circumstance of donor systemic infection with positive bacterial culture of PVB, the liver and kidney can be transplanted safely with prophylactic antibiotics. Donors with systemic infection are not a contraindication for organ donation.
authors.affiliation: Organ Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Electronic address: transplantyuan@163.com.
authors.forename: X
authors.initials: X
authors.lastname: Yuan
authors.affiliation: Organ Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: C
authors.initials: C
authors.lastname: Chen
authors.affiliation: Organ Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: J
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Organ Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: M
authors.initials: M
authors.lastname: Han
authors.affiliation: Organ Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.affiliation: Organ Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: C
authors.initials: C
authors.lastname: Wang
authors.affiliation: Organ Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: X
authors.initials: X
authors.lastname: He
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016470:Bacteremia / Q000635:transmission; D001424:Bacterial Infections / Q000635:transmission*; D001926:Brain Death; D002648:Child; D005260:Female; D006801:Humans; D007668:Kidney / Q000382:microbiology; D016030:Kidney Transplantation / Q000379:methods*; D008099:Liver / Q000382:microbiology; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018805:Sepsis / Q000635:transmission; D014019:Tissue Donors / Q000706:statistics & numerical data; D020858:Tissue and Organ Harvesting / Q000379:methods*; D009927:Tissue and Organ Procurement / Q000379:methods*; D055815:Young Adult