title: Lab-on-a-chip technologies for genodermatoses: Recent progress and future perspectives.
abstract: In recent years, molecular biology has proven to be a great asset in our understanding of mechanisms in genodermatoses. However, bench to bedside translation research lags far behind. Advances in lab-on-a-chip technologies enabled programmable, reconfigurable, and scalable manipulation of a variety of laboratory procedures. Sample preparation, microfluidic reactions, and continuous monitoring systems can be integrated on a small chip. These advantages have attracted attention in various fields of clinical application including diagnosis of inherited skin diseases. This review lists an overview of the underlying genes and mutations and describes prospective application of lab-on-a-chip technologies as solutions to challenges for point-of-care genodematoses diagnosis.
authors.affiliation: Department of Dermatology, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, PR China.
authors.forename: Cui
authors.initials: C
authors.lastname: Hongzhou
authors.affiliation: Department of Dermatology, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, PR China.
authors.forename: Guo
authors.initials: G
authors.lastname: Shuping
authors.affiliation: Department of Dermatology, The Second People's Hospital in Chengdu, Chengdu, Sichuan 610017, PR China.
authors.forename: Wang
authors.initials: W
authors.lastname: Wenju
authors.affiliation: Department of Dermatology, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Dermatology, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Lulu
authors.affiliation: Department of Dermatology, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, PR China.
authors.forename: Deng
authors.initials: D
authors.lastname: Linjun
authors.affiliation: Department of Dermatology, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Jingmin
authors.affiliation: Department of Dermatology, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, PR China.
authors.forename: Ren
authors.initials: R
authors.lastname: Xiaoli
authors.affiliation: Department of Dermatology, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, PR China. Electronic address: baili@medmail.com.cn.
authors.forename: Bai
authors.initials: B
authors.lastname: Li
mesh_terms: D004252:DNA Mutational Analysis / Q000295:instrumentation* / Q000379:methods / Q000639:trends; D005820:Genetic Testing / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D056656:Lab-On-A-Chip Devices / Q000639:trends*; D044085:Microfluidics / Q000295:instrumentation / Q000379:methods; D009154:Mutation; D020411:Oligonucleotide Array Sequence Analysis / Q000295:instrumentation* / Q000379:methods; D019095:Point-of-Care Systems / Q000639:trends*; D016133:Polymerase Chain Reaction; D012873:Skin Diseases, Genetic / Q000175:diagnosis* / Q000235:genetics; D013048:Specimen Handling / Q000379:methods; D013499:Surface Properties
keywords: Accumulated mutations; Genodermatoses; Lab-on-a-chip; Microfludic mutation screening; Molecular diagnosis