title: Bone Mineral Density and Fat-Soluble Vitamin Status in Adults with Cystic Fibrosis Undergoing Lung Transplantation: A Pilot Study.
abstract: Patients with cystic fibrosis (CF) often experience low bone mineral density (BMD) pre- and post-lung transplantation (LTX). The study purpose was to describe BMD and micronutrient status in adults with CF pre- and post-LTX.
  
  
  
  Twelve patients with CF (29 ± 8 years) were recruited from the CF clinic at the University of Alberta Lung Transplant Program. BMD and vitamins A, D, E, K status, and parathyroid hormone were measured pre- and post-LTX.
  
  
  
  No significant differences pre- and post-LTX were observed at the different bone sites measured (lumber-spine, femoral-neck (FN), hip, and femoral-trochlea) (P > 0.05). BMD T-scores (<-2) was present in lumbar-spine, FN, hip, and femoral-trochlea in 33%, 17%, 17%, and 25% of individuals pre-LTX and 58%, 33%, 58%, and 33% of individuals post-LTX, respectively. More than 50% of patients had suboptimal vitamin K levels (PIVKA-II values >3 ng/mL) pre- and post-LTX.
  
  
  
  Adults with CF pre- and post-LTX had reduced BMD and suboptimal vitamin K status.
authors.affiliation: a Nutrition Services, Alberta Health Services, Edmonton, AB.
authors.forename: Grace
authors.initials: G
authors.lastname: Hubert
authors.affiliation: a Nutrition Services, Alberta Health Services, Edmonton, AB.
authors.forename: Theresa Tam
authors.initials: TT
authors.lastname: Chung
authors.affiliation: b Department of Laboratory Medicine, University of Alberta, Edmonton, AB.
authors.forename: Connie
authors.initials: C
authors.lastname: Prosser
authors.affiliation: c Division of Pulmonary Medicine, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB.
authors.forename: Dale
authors.initials: D
authors.lastname: Lien
authors.affiliation: c Division of Pulmonary Medicine, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB.
authors.forename: Justin
authors.initials: J
authors.lastname: Weinkauf
authors.affiliation: c Division of Pulmonary Medicine, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB.
authors.forename: Neil
authors.initials: N
authors.lastname: Brown
authors.affiliation: d Lung Transplant Program, Alberta Health Services, Edmonton, AB.
authors.forename: Marianne
authors.initials: M
authors.lastname: Goodvin
authors.affiliation: d Lung Transplant Program, Alberta Health Services, Edmonton, AB.
authors.forename: Kathy
authors.initials: K
authors.lastname: Jackson
authors.affiliation: e Adult Cystic Fibrosis Clinic, Alberta Health Services, Edmonton, AB.
authors.forename: Joan
authors.initials: J
authors.lastname: Tabak
authors.affiliation: e Adult Cystic Fibrosis Clinic, Alberta Health Services, Edmonton, AB.
authors.forename: Josette
authors.initials: J
authors.lastname: Salgado
authors.affiliation: f Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB.
authors.forename: Abeer Salman
authors.initials: AS
authors.lastname: Alzaben
authors.affiliation: f Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB.|g Department of Pediatrics, University of Alberta, Edmonton, AB.
authors.forename: Diana R
authors.initials: DR
authors.lastname: Mager
mesh_terms: D000328:Adult; D000886:Anthropometry; D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D003550:Cystic Fibrosis / Q000097:blood*; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000378:metabolism; D008171:Lung Diseases / Q000601:surgery*; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000097:blood / Q000209:etiology; D010281:Parathyroid Hormone / Q000097:blood; D010865:Pilot Projects; D011498:Protein Precursors / Q000097:blood; D011516:Prothrombin; D014801:Vitamin A / Q000097:blood; D014807:Vitamin D / Q000097:blood; D014810:Vitamin E / Q000097:blood; D014812:Vitamin K / Q000097:blood; D014815:Vitamins / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D010281:Parathyroid Hormone; D011498:Protein Precursors; D014815:Vitamins; D014801:Vitamin A; D014812:Vitamin K; D014807:Vitamin D; D014810:Vitamin E; C008208:acarboxyprothrombin; D011516:Prothrombin