title: Novel aminoalkyl tris-cyclometalated iridium complexes as cellular stains.
abstract: Herein we report the synthesis and investigation of the properties of two tris-cyclometalated luminescent iridium complexes. These complexes are the simple derivatives of fac-[Ir(ppy)3] bearing amino alkyl groups on one of the phenylpyridine rings. The complexes are highly emissive and exhibit structured emission peaks in aqueous solution while having only broad unstructured emission in organic solvents. The complexes have been shown to be taken up by NIH-3T3 and PC3 cells, where they localize in the lysosomes and remain emissive with lifetimes in the microsecond domain.
authors.affiliation: Department of Chemistry, Naresuan University, Phitsanulok, 65000, Thailand. filipkielar@nu.ac.th.
authors.forename: A
authors.initials: A
authors.lastname: Sansee
authors.affiliation: Department of Chemistry, Naresuan University, Phitsanulok, 65000, Thailand. filipkielar@nu.ac.th.
authors.forename: S
authors.initials: S
authors.lastname: Meksawangwong
authors.affiliation: Department of Physics, Faculty of Science and Technology, Thammasat University, Khlong Luang, Pathum Thani 12120, Thailand.
authors.forename: K
authors.initials: K
authors.lastname: Chainok
authors.affiliation: Department of Chemistry, Duke University, Durham, NC 27708, USA.
authors.forename: K J
authors.initials: KJ
authors.lastname: Franz
authors.affiliation: Department of Chemistry, Slovak Technical University, Bratislava, Slovakia.
authors.forename: M
authors.initials: M
authors.lastname: Gál
authors.affiliation: Department of Chemistry, Durham University, Durham, DH1 3LE, UK.
authors.forename: L-O
authors.initials: LO
authors.lastname: Pålsson
authors.affiliation: Department of Chemistry, Naresuan University, Phitsanulok, 65000, Thailand. filipkielar@nu.ac.th.
authors.forename: W
authors.initials: W
authors.lastname: Puniyan
authors.affiliation: Laboratory of Advanced Polymers and Nanomaterials, Department of Chemistry and Center for Innovation in Chemistry, Naresuan Univesity, Phitsanulok, 65000, Thailand and Program in Materials Science, Mahidol University, Faculty of Science, Bangkok, 10400, Thailand and NANOTEC-MU Excellence Center on Intelligent Materials and Systems, Mahidol University, Faculty of Science, Bangkok, 10400, Thailand.
authors.forename: R
authors.initials: R
authors.lastname: Traiphol
authors.affiliation: Department of Chemistry, Durham University, Durham, DH1 3LE, UK.
authors.forename: R
authors.initials: R
authors.lastname: Pal
authors.affiliation: Department of Chemistry, Naresuan University, Phitsanulok, 65000, Thailand. filipkielar@nu.ac.th and Center of Excellence in Biomaterials, Naresuan University, Phitsanulok, 65000, Thailand.
authors.forename: F
authors.identifier: http://orcid.org/0000-0003-1785-3889
authors.initials: F
authors.lastname: Kielar
mesh_terms: D000631:Aminopyridines / Q000737:chemistry*; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D004705:Endocytosis; D006801:Humans; D007495:Iridium / Q000737:chemistry*; D049449:Luminescence; D049408:Luminescent Agents / Q000737:chemistry*; D008247:Lysosomes / Q000737:chemistry; D051379:Mice; D015394:Molecular Structure; D041681:NIH 3T3 Cells; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000631:Aminopyridines; D049408:Luminescent Agents; D009942:Organometallic Compounds; D007495:Iridium