title: Cardiovascular Profile of Propranolol after Multiple Dosing in Infantile Hemangioma.
abstract: Propranolol is becoming the treatment of choice for complicated infantile hemangioma. We report here data on peripheral blood flow, O2-saturation, electrocardiographic PR-interval, left ventricular function, blood pressure and heart rate that were assessed before and during treatment for ≥4 weeks with propranolol 2 mg/kg of body weight daily in 67 infants <12 months of age in normal sinus rhythm and with structurally normal hearts. Management with propranolol was well tolerated in all and did not modify peripheral blood flow, O2-saturation, electrocardiographic PR-interval and left ventricular fractional shortening or ejection fraction. Absolute blood pressure levels were similar without and with propranolol. However, age-adjusted centile levels for both systolic and diastolic levels were significantly lower while on propranolol. The heart rate was significantly lower both when expressed as absolute value and when expressed as age-adjusted centile on treatment with propranolol. In conclusion, propranolol 2 mg/kg of body weight daily causes a statistically though not clinically relevant decrease in blood pressure and heart rate in cardially healthy infants affected by infantile hemangioma. Temporary discontinuation during acute febrile illnesses and during diarrheal diseases should be considered to prevent excessive hypotension.
authors.affiliation: Department of Perinatal and Pediatric Cardiology, Fondazione Policlinico 'Ca' Granda' IRCCS, University of Milan, Milan, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Salice
authors.forename: Mario
authors.initials: M
authors.lastname: Giovanni Bianchetti
authors.forename: Alessandra
authors.initials: A
authors.lastname: Giavarini
authors.forename: Erica
authors.initials: E
authors.lastname: Gondoni
authors.forename: Riccardo
authors.initials: R
authors.lastname: Cavalli
authors.forename: Anna
authors.initials: A
authors.lastname: Maria Colli
authors.forename: Federico
authors.initials: F
authors.lastname: Lombardi
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D006391:Hemangioma / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007223:Infant; D008297:Male; D011433:Propranolol / Q000494:pharmacology* / Q000627:therapeutic use; D016277:Ventricular Function, Left / Q000187:drug effects* / Q000502:physiology
chemical_list: D000319:Adrenergic beta-Antagonists; D011433:Propranolol