title: Overcoming ATM Deficiency by Activating the NAD+/SIRT1 Axis.
abstract: In this issue, Fang et al. (2016) show that both the DNA repair defect and mitochondrial dysfunction in ATM-/-cells or mice are mitigated by the anti-aging compound nicotinamide riboside or a SIRT1 activator. This broad suppression by activating the NAD+/SIRT1 axis may generally apply to diseases and aging maladies.
authors.affiliation: Novartis Professor, Koch Institute Affiliate and Director of the Paul F. Glenn Center for the Science of Aging Research, MIT, Cambridge, MA 02139, USA. Electronic address: leng@mit.edu.
authors.forename: Leonard
authors.initials: L
authors.lastname: Guarente
mesh_terms: D000375:Aging; D000818:Animals; D051379:Mice; D009243:NAD; D056564:Sirtuin 1 / Q000235:genetics*
chemical_list: D009243:NAD; D056564:Sirtuin 1