title: Antioxidant Activity during Tumor Progression: A Necessity for the Survival of Cancer Cells?
abstract: Antioxidant defenses encompass a variety of distinct compounds and enzymes that are linked together through their capacity to neutralize and scavenge reactive oxygen species (ROS). While the relationship between ROS and tumorigenesis is clearly complex and context dependent, a number of recent studies have suggested that neutralizing ROS can facilitate tumor progression and metastasis in multiple cancer types through distinct mechanisms. These studies therefore infer that antioxidant activity may be necessary to support the viability and/or the invasive capacity of cancer cells during tumor progression and metastasis. Here, we discuss some of the accumulating evidence suggesting a role for antioxidant activity in facilitating tumor progression.
authors.affiliation: Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA. Mark.A.Hawk.3@nd.edu.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Hawk
authors.affiliation: Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA. Chelsea.M.McCallister.2@nd.edu.
authors.forename: Chelsea
authors.initials: C
authors.lastname: McCallister
authors.affiliation: Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA. zschafe1@nd.edu.
authors.forename: Zachary T
authors.initials: ZT
authors.lastname: Schafer
keywords: NADPH; Nrf2; antioxidant; extracellular matrix; metastasis; pentose phosphate pathway; reactive oxygen species