title: DCE-MRI Perfusion and Permeability Parameters as predictors of tumor response to CCRT in Patients with locally advanced NSCLC.
abstract: In this prospective study, 36 patients with stage III non-small cell lung cancers (NSCLC), who underwent dynamic contrast-enhanced MRI (DCE-MRI) before concurrent chemo-radiotherapy (CCRT) were enrolled. Pharmacokinetic analysis was carried out after non-rigid motion registration. The perfusion parameters [including Blood Flow (BF), Blood Volume (BV), Mean Transit Time (MTT)] and permeability parameters [including endothelial transfer constant (Ktrans), reflux rate (Kep), fractional extravascular extracellular space volume (Ve), fractional plasma volume (Vp)] were calculated, and their relationship with tumor regression was evaluated. The value of these parameters on predicting responders were calculated by receiver operating characteristic (ROC) curve. Multivariate logistic regression analysis was conducted to find the independent variables. Tumor regression rate is negatively correlated with Veand its standard variation Ve_SD and positively correlated with Ktransand Kep. Significant differences between responders and non-responders existed in Ktrans, Kep, Ve, Ve_SD, MTT, BV_SD and MTT_SD (P < 0.05). ROC indicated that Ve< 0.24 gave the largest area under curve of 0.865 to predict responders. Multivariate logistic regression analysis also showed Vewas a significant predictor. Baseline perfusion and permeability parameters calculated from DCE-MRI were seen to be a viable tool for predicting the early treatment response after CCRT of NSCLC.
authors.affiliation: Department of Diagnostic Radiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing, China.|PET-CT Center, National Center/Cancer Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing, China.
authors.forename: Xiuli
authors.initials: X
authors.lastname: Tao
authors.affiliation: Department of Radiation Oncology, National Center/Cancer Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing, China.
authors.forename: Lvhua
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Radiation Oncology, National Center/Cancer Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing, China.
authors.forename: Zhouguang
authors.initials: Z
authors.lastname: Hui
authors.affiliation: Department of Diagnostic Radiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Diagnostic Radiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Ye
authors.affiliation: Department of Diagnostic Radiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Song
authors.affiliation: Department of Radiation Oncology, National Center/Cancer Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Radiation Oncology, National Center/Cancer Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Men
authors.affiliation: University of Lincoln, Lincoln School of Computer Science, Lincoln, LN6 7TS, United Kingdom.
authors.forename: Tryphon
authors.initials: T
authors.lastname: Lambrou
authors.affiliation: GE Healthcare, 10 Ronghua Road, Beijing, 100176, China.
authors.forename: Zihua
authors.initials: Z
authors.lastname: Su
authors.affiliation: GE Healthcare, 10 Ronghua Road, Beijing, 100176, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Diagnostic Radiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing, China.
authors.forename: Han
authors.initials: H
authors.lastname: Ouyang
authors.affiliation: Department of Diagnostic Radiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing, China.|PET-CT Center, National Center/Cancer Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D002289:Carcinoma, Non-Small-Cell Lung / Q000098:blood supply / Q000000981:diagnostic imaging / Q000628:therapy; D059248:Chemoradiotherapy; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000000981:diagnostic imaging / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies