title: Alopecia areata: What's new in epidemiology, pathogenesis, diagnosis, and therapeutic options?
abstract: Alopecia areata (AA) is a common and stressful disorder that results in hair loss, and resistant to treatment in some cases. Experimental and clinical evidence suggests that AA is caused by autoimmune attack against the hair follicles. The precise pathomechanism, however, remains unknown. Here, we focus on the recent progress in multidisciplinary approaches to the epidemiology, pathogenesis, and new treatments of AA in 996 publications from January 2010 to July 2016, and provide an overview of the current understanding in clinical management and research directions.
authors.affiliation: Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan. Electronic address: dainichi@kuhp.kyoto-u.ac.jp.
authors.forename: Teruki
authors.initials: T
authors.lastname: Dainichi
authors.affiliation: Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Singapore Immunology Network (SIgN) and Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore; PRESTO, Japan Science and Technology Agency, Kawaguchi, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Kabashima
mesh_terms: D000287:Administration, Topical; D000506:Alopecia Areata / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology* / Q000628:therapy; D001323:Autoantibodies / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology* / Q000628:therapy; D015415:Biomarkers / Q000097:blood; D018925:Chemokines / Q000276:immunology; D017679:Cryotherapy; D046169:Dermoscopy; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D018859:Hair Follicle / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D015994:Incidence; D010789:Phototherapy; D017410:Practice Guidelines as Topic; D020551:Pulse Therapy, Drug; D011788:Quality of Life; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D015415:Biomarkers; D018925:Chemokines; D005938:Glucocorticoids
keywords: Alopecia areata; Autoimmunity; Diagnosis; Epidemiology; Genetics; Treatment