title: The Outpatient Treatment of Venous Thromboembolism: Operational Impact and the Role of Novel Anticoagulants.
abstract: Pulmonary embolism (PE) and venous thromboembolism (VTE) are common diagnoses in the emergency department (ED), with significant potential morbidity and mortality. As a result, historically nearly all patients with PE have been admitted to the hospital for observation and treatment. In recent years, the ability to rapidly and accurately risk stratify patients with VTE according to their risk of short-term clinical deterioration has supported outpatient treatment, and non-vitamin K antagonist oral anticoagulants (NOACs) have further facilitated this approach. This review details the historical context and operational impact of managing VTE in the outpatient setting, describes a model for outpatient management of VTE, and suggests potential areas of further inquiry.
authors.affiliation: Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: Benjamin
authors.initials: B
authors.lastname: White
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: Rachel
authors.initials: R
authors.lastname: Rosovsky
authors.affiliation: Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: Blair Alden
authors.initials: BA
authors.lastname: Parry
authors.affiliation: Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: Christopher
authors.initials: C
authors.lastname: Kabrhel
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D010045:Outpatients; D011655:Pulmonary Embolism / Q000188:drug therapy*; D054556:Venous Thromboembolism / Q000188:drug therapy*
chemical_list: D000925:Anticoagulants