title: No Decrease in Knee Survivorship or Outcomes Scores for Patients With HIV Infection Who Undergo TKA.
abstract: BACKGROUND
  HIV is prevalent worldwide and numerous patients with this diagnosis ultimately may become candidates for TKA. Although some studies have suggested that complications are more common in patients with HIV who undergo TKA, these studies largely were done before the contemporary era of HIV management; moreover, it is unclear whether patients with HIV achieve lower patient-reported outcome scores or inferior implant survivorship.
  
  
  OBJECTIVE
  We asked whether there were any differences in the outcomes of patients with HIV without hemophilia who undergo TKA compared with a matched control cohort in terms of: (1) patient-reported outcomes; (2) implant survivorship; and (3) complication rates.
  
  
  METHODS
  Forty-five patients with HIV who had undergone 50 TKAs at three institutions with a minimum followup of 4 years between 2005 and 2011 were identified. An additional three patients were lost to followup before the fourth-year annual visit. All patients with HIV underwent thorough preoperative optimization with their primary care physician and infectious disease specialist. There were 31 men and 14 women with a mean age of 57 years and mean followup of 6 years (range, 4-10 years). These patients were compared with a matched cohort of 135 patients (one-to-three ratio) who did not have HIV and who had undergone a primary TKA by the same surgeons during this same period using the same implant. Matching criteria included patient age (within 2 years), BMI (within 2 kg/m2), surgeon performing TKA, followup (within 6 months), minimum followup of 4 years, sex ratio, and primary diagnosis (degenerative joint disease versus osteonecrosis). Approximately 10% of patients in the matching group had not returned for followup after their sixth annual visit. Outcomes evaluated included The Knee Society objective and function scores, University of California, Los Angeles (UCLA) activity scores, overall implant survivorship (free of revision) using Kaplan-Meier analysis, and complications. With the numbers available, there were no differences in preoperative Knee Society score or UCLA activity scores among the cohorts.
  
  
  RESULTS
  With the numbers available, there were no differences in the mean Knee Society objective scores between patients with HIV (89 ± 11 points) and the matching cohort (91 ± 14 points) (95% CI, -7 to 3; p = 0.38). There were no differences among the Knee Society functional component as well (88 ± 12 points versus 90 ± 13 points; 95% CI, -6 to 2; p = 0.36) at latest followup. Similarly, there were no differences with the numbers available in the UCLA activity scores (6 ± 5 points [range, 4-7] versus 6 ± 7 points [range, 4-8]; p = 0.87) between the cohorts. With the numbers available, Kaplan-Meier analysis showed no significant difference in the overall implant survivorships between patients with HIV (98%; 95% CI, 94%-99%) compared with the matching group (99%; 95% CI, 98%-100%; p = 0.89). Postoperative complications were also comparable between the two groups.
  
  
  CONCLUSIONS
  With the numbers available, we found that patients with HIV had no differences in clinical scores and implant survivorship compared with patients without the disease at mid-term followup. We believe practitioners should not be reluctant to perform TKA on this patient population. However, we believe the preoperative optimization process is crucial to achieving good outcomes and minimizing the risk of complications. Future comparative studies should have longer followup and a larger sample size with greater power to determine if there are differences in complications and implant survivorship.
  
  
  METHODS
  Level III, therapeutic study.
authors.affiliation: Department of Orthopaedics, School of Health and Medical Sciences, Seton Hall University, South Orange, NJ, USA.
authors.forename: Kimona
authors.initials: K
authors.lastname: Issa
authors.affiliation: Department of Orthopaedics, School of Health and Medical Sciences, Seton Hall University, South Orange, NJ, USA.
authors.forename: Todd P
authors.initials: TP
authors.lastname: Pierce
authors.affiliation: Center for Reconstructive Joint Surgery, Mount Sinai Beth Israel Medical Center, New York, NY, USA.
authors.forename: Steven F
authors.initials: SF
authors.lastname: Harwin
authors.affiliation: Department of Orthopaedics, School of Health and Medical Sciences, Seton Hall University, South Orange, NJ, USA.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Scillia
authors.affiliation: Department of Orthopaedics, School of Health and Medical Sciences, Seton Hall University, South Orange, NJ, USA.
authors.forename: Anthony
authors.initials: A
authors.lastname: Festa
authors.affiliation: Department of Orthopaedics, Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk A4-519, Cleveland, OH, 44195, USA. montm@ccf.org.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Mont
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019645:Arthroplasty, Replacement, Knee; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007719:Knee Joint / Q000601:surgery*; D007720:Knee Prosthesis; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000150:complications / Q000601:surgery*; D011475:Prosthesis Failure; D020127:Recovery of Function; D012086:Reoperation; D012189:Retrospective Studies; D016896:Treatment Outcome