title: [Therapy of adult-onset laryngeal papilloma: integrallty submucosal dissection of the tumor by CO2laser].
abstract: Objective:To evaluate the feasibility and efficacy of the integrallty submucosal resection of adult-onset laryngeal papilloma by CO2laser.Methods:A group of 64 cases (36 males and 28 females, multipe lesions 54 cases and single lesion 10 cases, aged 18-75 years, mean age 43.13 years) with adult-onset laryngeal papilloma encountered in the first affliated hospital of Sun Yatsen university from 2009 to 2015 was retrospectively analyzed. All cases were treated with integrallty submucosal dissection of the tumor by CO2laser, and observed the changes of tumor integral scope, inter-operative, operative processes, postoperative voice quality, postoperative scarring, and the tracheotomy conditions, which were analysed and evaluated.Results:A total of 64 patients were followed up from 1 year to 5 years. Preoperative tumor integral scope of these patients averaged of 7.00. A total of 62 cases kept 0 score of the tumor integral scope for at least one year, which lead to a clinical cure rate of 96.9%. The inter-operative averaged of 25.7 months. The total operative processes of these patients were 87 times (mean time 1.36). Four cases resulted in postoperative scarring. However these was a good result in postoperative voice quality with a mean score 4.25. As to the changes of tumor integral scope, all cases got a declining score (mean score 6.72), which resulted in a remission rate of 100%.Conclusion:The integrallty submucosal dissection of adult-onset 1aryngeal papilloma by CO2laser was an effective way to reduce the tumor integral scope; lengthen their inter-operative; decrease the operative processes, avoid the occurrence of tracheotomy; and improve the postoperative voice quality. Most of the patients could even be cured ultimately.
authors.affiliation: Department of Otorhinolaryngology, the First Affliated Hospital of Sun Yatsen University, Guangzhou 510800, China.
authors.forename: W B
authors.initials: WB
authors.lastname: Lei
authors.affiliation: Department of Otorhinolaryngology, the Eighth Affliated Hospital of Sun Yatsen University, Shenzhen 518033, China.
authors.forename: Q H
authors.initials: QH
authors.lastname: Liu
authors.affiliation: Department of Otorhinolaryngology, the First Affliated Hospital of Sun Yatsen University, Guangzhou 510800, China.
authors.forename: L P
authors.initials: LP
authors.lastname: Chai
authors.affiliation: Department of Otorhinolaryngology, the First Affliated Hospital of Sun Yatsen University, Guangzhou 510800, China.
authors.forename: X L
authors.initials: XL
authors.lastname: Zhu
authors.affiliation: Department of Otorhinolaryngology, the First Affliated Hospital of Sun Yatsen University, Guangzhou 510800, China.
authors.forename: Z F
authors.initials: ZF
authors.lastname: Wang
authors.affiliation: Department of Otorhinolaryngology, the Eighth Affliated Hospital of Sun Yatsen University, Shenzhen 518033, China.
authors.forename: Q M
authors.initials: QM
authors.lastname: Li
authors.affiliation: Department of Otorhinolaryngology, the First Affliated Hospital of Sun Yatsen University, Guangzhou 510800, China.
authors.forename: H C
authors.initials: HC
authors.lastname: Tang
authors.affiliation: Department of Otorhinolaryngology, the First Affliated Hospital of Sun Yatsen University, Guangzhou 510800, China.
authors.forename: A Y
authors.initials: AY
authors.lastname: Jiang
authors.affiliation: Department of Otorhinolaryngology, the First Affliated Hospital of Sun Yatsen University, Guangzhou 510800, China.
authors.forename: Y H
authors.initials: YH
authors.lastname: Wen
authors.affiliation: Department of Otorhinolaryngology, the First Affliated Hospital of Sun Yatsen University, Guangzhou 510800, China.
authors.forename: W P
authors.initials: WP
authors.lastname: Wen
mesh_terms: D000328:Adult; D000368:Aged; D002921:Cicatrix / Q000000981:diagnostic imaging / Q000209:etiology; D004210:Dissection / Q000379:methods; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000601:surgery*; D053685:Laser Therapy / Q000009:adverse effects / Q000379:methods*; D054020:Lasers, Gas / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010212:Papilloma / Q000601:surgery*; D011183:Postoperative Complications / Q000000981:diagnostic imaging; D011230:Precancerous Conditions; D012074:Remission Induction; D012189:Retrospective Studies; D014140:Tracheotomy; D014833:Voice Quality