title: Trapping σ-Alkyl-Palladium(II) Intermediates with Arynes Encompassing Intramolecular C-H Activation: Spirobiaryls through Pd-Catalyzed Cascade Reactions.
abstract: A palladium-catalyzed cascade reaction based on the trapping of transient alkyl-PdIIintermediates with arynes encompassing a C-H activation step has been developed. This synthetic pathway gives rise to hetero-spirocyclic scaffolds containing a biaryl motif, and opens up new synthetic strategies in the design of cascade reactions since it gathers several aspects of Pd chemistry, i.e., intra- and intermolecular carbopalladation of unsaturated species, C-H activation and C-C coupling processes.
authors.affiliation: Grupo de Química Organometálica. Dpto. Química Inorgánica, Universidad de Murcia, Campus de Espinardo, 30100, Murcia, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Pérez-Gómez
authors.affiliation: Grupo de Química Organometálica. Dpto. Química Inorgánica, Universidad de Murcia, Campus de Espinardo, 30100, Murcia, Spain. joangalo@um.es.
authors.forename: José-Antonio
authors.identifier: 0000-0002-8143-7081
authors.initials: JA
authors.lastname: García-López
keywords: C−H activation; aryne; carbopalladation; cascade reactions; spirocycles