title: Two new benzoate derivatives and one new phenylacetate derivative from a marine-derived fungus Engyodontium album.
abstract: Two new benzoate derivatives, ethyl 3,5-dimethoxy-2-propionylbenzoate (1) and ethyl 3,5-dihydroxy-2-propionylbenzoate (2), and one new phenylacetate derivative, ethyl 3,5-dimethoxy-2-propionylphenylacetate (3), together with 9 known compounds, were isolated from the fermentation of Engyodontium album derived from deep sea sediment. Their structures were elucidated by spectroscopic techniques, such as NMR, IR and HRESIMS. Compound 3 exhibited inhibitory activities against methicillin-resistant Staphylococcus aureus ATCC 43300 (MRSA) and Vibrio vulnificus, with MIC values of 7.8 and 15.6 μg/mL, respectively.
authors.affiliation: a Key Laboratory of Marine Biogenetic Resources, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources , Third Institute of Oceanography, State Oceanic Administration , Xiamen , China.|b Key Laboratory of Urban Environment and Health , Institute of Urban Environment, Chinese Academy of Sciences , Xiamen , China.
authors.forename: Weiyi
authors.initials: W
authors.lastname: Wang
authors.affiliation: a Key Laboratory of Marine Biogenetic Resources, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources , Third Institute of Oceanography, State Oceanic Administration , Xiamen , China.
authors.forename: Ruixuan
authors.initials: R
authors.lastname: Chen
authors.affiliation: a Key Laboratory of Marine Biogenetic Resources, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources , Third Institute of Oceanography, State Oceanic Administration , Xiamen , China.
authors.forename: Zhuhua
authors.initials: Z
authors.lastname: Luo
authors.affiliation: a Key Laboratory of Marine Biogenetic Resources, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources , Third Institute of Oceanography, State Oceanic Administration , Xiamen , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: a Key Laboratory of Marine Biogenetic Resources, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources , Third Institute of Oceanography, State Oceanic Administration , Xiamen , China.
authors.forename: Jianming
authors.initials: J
authors.lastname: Chen
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D059001:Aquatic Organisms / Q000737:chemistry; D001203:Ascomycota / Q000737:chemistry*; D001565:Benzoates / Q000737:chemistry / Q000302:isolation & purification*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005285:Fermentation; D019015:Geologic Sediments / Q000382:microbiology; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010648:Phenylacetates / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000900:Anti-Bacterial Agents; D001565:Benzoates; D010648:Phenylacetates; C000618932:ethyl 3,5-dihydroxy-2-propionylbenzoate; C000618931:ethyl 3,5-dimethoxy-2-propionylbenzoate; C000618933:ethyl 3,5-dimethoxy-2-propionylphenylacetate
keywords: Engyodontium album; antibacterial; benzoate derivative; phenylacetate derivative