title: A New Dioic Acid from a wbl Gene Mutant of Deepsea-Derived Streptomyces somaliensis SCSIO ZH66.
abstract: ThewblAsogene functions as a global regulatory gene in a negative manner in deepsea-derivedStreptomyces somaliensisSCSIO ZH66. A new dioic acid (1) as well as two known butenolides (2and3) were isolated from theΔwblAsomutant strain ofS. somaliensisSCSIO ZH66. The structure of1was elucidated by a combination of spectroscopic analyses, including MS and NMR techniques. In the cell growth inhibitory evaluation, compound3exhibited moderate activity against the human hepatic carcinoma cell line (Huh7.5) with an IC50value of 19.4 μg/mL, while compounds1and2showed null activity up to 100 μg/mL.
authors.affiliation: Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. hmhuang1988@163.com.
authors.forename: Huiming
authors.initials: H
authors.lastname: Huang
authors.affiliation: Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. lihuayue@ouc.edu.cn.
authors.forename: Huayue
authors.initials: H
authors.lastname: Li
authors.affiliation: Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. qq2yanhong@163.com.
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Qiu
authors.affiliation: Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. houlukuan1991@163.com.
authors.forename: Lukuan
authors.initials: L
authors.lastname: Hou
authors.affiliation: CAS Key Laboratory of Marine Bio-resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China. jju@scsio.ac.cn.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Ju
authors.affiliation: Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. liwenli@ouc.edu.cn.|Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China. liwenli@ouc.edu.cn.
authors.forename: Wenli
authors.initials: W
authors.lastname: Li
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D003998:Dicarboxylic Acids / Q000737:chemistry* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D009154:Mutation / Q000235:genetics; D012623:Seawater / Q000382:microbiology*; D013302:Streptomyces / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D003998:Dicarboxylic Acids
keywords: deepsea-derived Streptomyces; dioic acid; wblAso