title: Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications.
abstract: This review focuses on the contribution of white, brown, and perivascular adipose tissues to the pathophysiology of obesity and its associated metabolic and vascular complications. Weight gain in obesity generates excess of fat, usually visceral fat, and activates the inflammatory response in the adipocytes and then in other tissues such as liver. Therefore, low systemic inflammation responsible for insulin resistance contributes to atherosclerotic process. Furthermore, an inverse relationship between body mass index and brown adipose tissue activity has been described. For these reasons, in recent years, in order to combat obesity and its related complications, as a complement to conventional treatments, a new insight is focusing on the role of the thermogenic function of brown and perivascular adipose tissues as a promising therapy in humans. These lines of knowledge are focused on the design of new drugs, or other approaches, in order to increase the mass and/or activity of brown adipose tissue or the browning process of beige cells from white adipose tissue. These new treatments may contribute not only to reduce obesity but also to prevent highly prevalent complications such as type 2 diabetes and other vascular alterations, such as hypertension or atherosclerosis.
authors.affiliation: Biochemistry and Molecular Biology Department, School of Pharmacy, Complutense University of Madrid, Madrid, Spain; CIBER of Diabetes and Associated Metabolic Diseases, Madrid, Spain; Instituto de Investigación Sanitaria Hospital Clínico San Carlos, IdISSC, Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Almudena
authors.identifier: 0000-0002-2742-4298
authors.initials: A
authors.lastname: Gómez-Hernández
authors.affiliation: Biochemistry and Molecular Biology Department, School of Pharmacy, Complutense University of Madrid, Madrid, Spain; CIBER of Diabetes and Associated Metabolic Diseases, Madrid, Spain; Instituto de Investigación Sanitaria Hospital Clínico San Carlos, IdISSC, Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Beneit
authors.affiliation: Biochemistry and Molecular Biology Department, School of Pharmacy, Complutense University of Madrid, Madrid, Spain; CIBER of Diabetes and Associated Metabolic Diseases, Madrid, Spain; Instituto de Investigación Sanitaria Hospital Clínico San Carlos, IdISSC, Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Sabela
authors.initials: S
authors.lastname: Díaz-Castroverde
authors.affiliation: Biochemistry and Molecular Biology Department, School of Pharmacy, Complutense University of Madrid, Madrid, Spain; CIBER of Diabetes and Associated Metabolic Diseases, Madrid, Spain; Instituto de Investigación Sanitaria Hospital Clínico San Carlos, IdISSC, Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Óscar
authors.identifier: 0000-0002-8249-1645
authors.initials: Ó
authors.lastname: Escribano