title: Effect of oral theaflavin administration on body weight, fat, and muscle in healthy subjects: a randomized pilot study.
abstract: Theaflavins are reddish-colored polyphenols in black tea. To test the efficacy of theaflavin administration on body fat and muscle, we performed a randomized, double-blind, placebo-controlled study and investigated the effect of theaflavins administration on the body composition using of healthy subjects. In this study, 30 male and female Japanese were enrolled and participants were randomly allocated to receive placebo, theaflavin (50 or 100 mg/day), or catechin (400 mg/ml) for 10 weeks. The effects were evaluated using body weight, body fat percentage, subcutaneous fat percentage, and skeletal muscle percentage. Theaflavin administration significantly improved body fat percentage, subcutaneous fat percentage, and skeletal muscle percentage when compared to with the placebo. In contrast, there was no significant difference in all measured outcomes between the catechin and the placebo groups. The results indicate that oral administration of theaflavin had a beneficial effect on body fat and muscle in healthy individuals.
authors.affiliation: a R&D Division , Yaizu Suisankagaku Industry Co., Ltd. , Shizuoka , Japan.
authors.forename: Teruki
authors.initials: T
authors.lastname: Aizawa
authors.affiliation: a R&D Division , Yaizu Suisankagaku Industry Co., Ltd. , Shizuoka , Japan.
authors.forename: Ayaka
authors.initials: A
authors.lastname: Yamamoto
authors.affiliation: a R&D Division , Yaizu Suisankagaku Industry Co., Ltd. , Shizuoka , Japan.
authors.forename: Tomoya
authors.initials: T
authors.lastname: Ueno
mesh_terms: D000284:Administration, Oral; D000328:Adult; D044946:Biflavonoids / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects*; D028241:Camellia sinensis / Q000737:chemistry; D002392:Catechin / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects*; D012449:Safety; D050151:Subcutaneous Fat / Q000187:drug effects*
chemical_list: D044946:Biflavonoids; C056068:theaflavin; D002392:Catechin
keywords: black tea; body composition; body fat; polyphenol; theaflavin