title: Copper-Mediated Oxidative Functionalization of C(sp3)-H Bonds with Isoquinolines: Two-Step Synthesis of 5-Oxaprotoberberinones.
abstract: A copper-mediated oxidative functionalization of C(sp3)-H bonds with isoquinolines via a radical process without ligands was achieved. The present system exhibits a novel pathway for the preparation of N-alkyl (benzyl) isoquinolin-1(2H)-ones in moderate to high yields. In addition, this procedure provides a simple method to afford 5-oxaprotoberberinones and their derivatives in two steps.
authors.affiliation: College of Chemistry, Nanchang University , Nanchang, Jiangxi 330031, China.
authors.forename: Dingyi
authors.initials: D
authors.lastname: Wang
authors.affiliation: College of Chemistry, Nanchang University , Nanchang, Jiangxi 330031, China.
authors.forename: Rongxing
authors.initials: R
authors.lastname: Zhang
authors.affiliation: College of Chemistry, Nanchang University , Nanchang, Jiangxi 330031, China.
authors.forename: Ruihong
authors.initials: R
authors.lastname: Deng
authors.affiliation: College of Chemistry, Nanchang University , Nanchang, Jiangxi 330031, China.
authors.forename: Sen
authors.initials: S
authors.lastname: Lin
authors.affiliation: College of Chemistry, Nanchang University , Nanchang, Jiangxi 330031, China.
authors.forename: Shengmei
authors.initials: S
authors.lastname: Guo
authors.affiliation: College of Chemistry, Nanchang University , Nanchang, Jiangxi 330031, China.
authors.forename: Zhaohua
authors.initials: Z
authors.lastname: Yan