title: Ebola vaccines in clinical trial: The promising candidates.
abstract: Ebola virus disease (EVD) has become a great threat to humans across the world in recent years. The 2014 Ebola epidemic in West Africa caused numerous deaths and attracted worldwide attentions. Since no specific drugs and treatments against EVD was available, vaccination was considered as the most promising and effective method of controlling this epidemic. So far, 7 vaccine candidates had been developed and evaluated through clinical trials. Among them, the recombinant vesicular stomatitis virus-based vaccine (rVSV-EBOV) is the most promising candidate, which demonstrated a significant protection against EVD in phase III clinical trial. However, several concerns were still associated with the Ebola vaccine candidates, including the safety profile in some particular populations, the immunization schedule for emergency vaccination, and the persistence of the protection. We retrospectively reviewed the current development of Ebola vaccines and discussed issues and challenges remaining to be investigated in the future.
authors.affiliation: a School of Public Health; Southeast University , Nanjing , PR China.
authors.forename: Yuxiao
authors.initials: Y
authors.lastname: Wang
authors.affiliation: b Jiangsu Provincial Center for Disease Control and Prevention , Nanjing , PR China.
authors.forename: Jingxin
authors.initials: J
authors.lastname: Li
authors.affiliation: b Jiangsu Provincial Center for Disease Control and Prevention , Nanjing , PR China.
authors.forename: Yuemei
authors.initials: Y
authors.lastname: Hu
authors.affiliation: b Jiangsu Provincial Center for Disease Control and Prevention , Nanjing , PR China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Liang
authors.affiliation: c School of Public Health, Nanjing Medical University , Nanjing , PR China.
authors.forename: Mingwei
authors.initials: M
authors.lastname: Wei
authors.affiliation: b Jiangsu Provincial Center for Disease Control and Prevention , Nanjing , PR China.
authors.forename: Fengcai
authors.initials: F
authors.lastname: Zhu
mesh_terms: D002986:Clinical Trials as Topic; D046129:Ebola Vaccines / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology*; D019142:Hemorrhagic Fever, Ebola / Q000517:prevention & control*; D006801:Humans
chemical_list: D046129:Ebola Vaccines
keywords: Ebola virus; clinical trial; efficacy; immunogenicity; safety; vaccine