title: Occurrence of the Plasmid-Mediated Fluoroquinolone Resistance qepA1 Gene in Two Clonal Clinical Isolates of CTX-M-15-Producing Escherichia coli from Algeria.
abstract: QepA is a plasmid-mediated quinolone resistance determinant of low prevalence described worldwide, mainly in Enterobacteriaceae. This study describes, for the first time in Algeria, two clonally related, QepA-producing Escherichia coli clinical isolates positive for CTX-M-15. The clonal spread of these multidrug-resistant isolates is a major public health concern.
authors.affiliation: 1 Laboratoire d'Ecologie Microbienne, FSNV, Université de Bejaia , Bejaia, Algeria .|2 Department of Microbiology, University of Seville , Seville, Spain .
authors.forename: Betitera
authors.initials: B
authors.lastname: Yanat
authors.affiliation: 3 Service de Bactériologie Etablissement Hospitalier et Universitaire d'Oran, Université d'Oran Faculté de Médecine , Oran, Algeria .
authors.forename: Radia
authors.initials: R
authors.lastname: Dali Yahia
authors.affiliation: 3 Service de Bactériologie Etablissement Hospitalier et Universitaire d'Oran, Université d'Oran Faculté de Médecine , Oran, Algeria .
authors.forename: Leila
authors.initials: L
authors.lastname: Yazi
authors.affiliation: 2 Department of Microbiology, University of Seville , Seville, Spain .|4 Spanish Network for the Research in Infectious Diseases (REIPI RD12/0015), Instituto de Salud Carlos III , Madrid, Spain .|5 Unidad Intercentros de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena , Sevilla, Spain .
authors.forename: Jesús
authors.initials: J
authors.lastname: Machuca
authors.affiliation: 5 Unidad Intercentros de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena , Sevilla, Spain .
authors.forename: Paula
authors.initials: P
authors.lastname: Díaz-De-Alba
authors.affiliation: 1 Laboratoire d'Ecologie Microbienne, FSNV, Université de Bejaia , Bejaia, Algeria .
authors.forename: Abdelaziz
authors.initials: A
authors.lastname: Touati
authors.affiliation: 2 Department of Microbiology, University of Seville , Seville, Spain .|4 Spanish Network for the Research in Infectious Diseases (REIPI RD12/0015), Instituto de Salud Carlos III , Madrid, Spain .|5 Unidad Intercentros de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena , Sevilla, Spain .
authors.forename: Álvaro
authors.initials: Á
authors.lastname: Pascual
authors.affiliation: 2 Department of Microbiology, University of Seville , Seville, Spain .|4 Spanish Network for the Research in Infectious Diseases (REIPI RD12/0015), Instituto de Salud Carlos III , Madrid, Spain .
authors.forename: José-Manuel
authors.initials: JM
authors.lastname: Rodríguez-Martínez
mesh_terms: D000462:Algeria; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002999:Clone Cells; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D016521:Electrophoresis, Gel, Pulsed-Field; D004926:Escherichia coli / Q000145:classification / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000382:microbiology; D029968:Escherichia coli Proteins / Q000235:genetics* / Q000378:metabolism; D024841:Fluoroquinolones / Q000494:pharmacology*; D015870:Gene Expression; D006801:Humans; D010802:Phylogeny; D010957:Plasmids / Q000737:chemistry* / Q000378:metabolism; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D029968:Escherichia coli Proteins; D024841:Fluoroquinolones; D020033:Protein Isoforms; C524438:QepA protein, E coli; C473109:beta-lactamase CTX-M-15; D001618:beta-Lactamases
keywords: Algeria; E. coli; QepA; clinical