title: SUV measurement of normal vertebrae using SPECT/CT with Tc-99m methylene diphosphonate.
abstract: The purpose of this study is to perform quantitative measurement based on the standardized uptake value (SUV) of the uptake of Tc-99m methylene diphosphonate (MDP) in the normal vertebrae using a single photon emission tomography (SPECT)/computed tomography (CT) scanner. A retrospective study of patients with cancer or joint disorders was performed. We acquired data for a group of 29 patients (8 women and 21 men; mean age, 68.2 ± 6.7 years; age range, 44-87 years) undergoing bone SPECT/CT scans with Tc-99m MDP between September and October 2015. Various SUVs were calculated based on body-weight, lean-body-weight (lbw), Japanese lean-body-weight (jlbw) and Japanese bone-mineral-content (jbmc). SUVs of normal vertebrae showed a wide range of values. Among these, the maximum body-weight based SUV showed the lowest coefficient of variation. The SUVs also showed relatively small intra-subject variability. In addition, all SUVs showed moderate and significant correlation with height. Moreover, lbw-, jlbw-, and jbmc-based SUVs of men were significantly higher than those of women. In conclusions, SUVs of normal vertebrae showed a relatively large inter-individual variability and small intra-individual variability. As a quantitative imaging biomarker, SUVs might require standardization with adequate reference data for the same subject to minimize variability.
authors.affiliation: Department of Radiology, Yokohama City University 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004 Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kaneta
authors.affiliation: Department of Radiology, Yokohama City University 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004 Japan.
authors.forename: Matsuyoshi
authors.initials: M
authors.lastname: Ogawa
authors.affiliation: Nihon Medi-Physics Co., Ltd. 3-4-10, Shinsuna, Koto-ku, Tokyo, 136-0075 Japan.
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Daisaki
authors.affiliation: Department of Radiology, Yokohama City University 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004 Japan.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Nawata
authors.affiliation: Department of Radiology, Yokohama City University 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004 Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Yoshida
authors.affiliation: Department of Radiology, Yokohama City University 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004 Japan.
authors.forename: Tomio
authors.initials: T
authors.lastname: Inoue
keywords: QIBA; SPECT; SPECT/CT; SUV; bone