title: Clinical outcomes and antibiotic susceptibilities of Staphylococcus aureus endophthalmitis.
abstract: OBJECTIVE
  To compare the antibiotic susceptibilities and visual acuity (VA) outcomes in endophthalmitis caused by methicillin-resistant (MRSA) versus methicillin-sensitive S. aureus (MSSA).
  
  
  METHODS
  The records of 34 cases of S. aureus endophthalmitis at The New York Eye and Ear Infirmary from Jan 1997 to June 2011 were reviewed. Antibiotic susceptibility profiles over time and VA at presentation and at 3, 6, and ≥12 months were recorded. S. aureus isolates were grouped based on oxacillin resistance.
  
  
  RESULTS
  Of the 34 cases, 15 (44 %) were MRSA and 19 (56 %) MSSA. Median presenting VA was hand motions (logMAR 4.0) in both the MRSA and MSSA groups. There was no statistically significant difference in VA between the MRSA and MSSA groups at 3, 6, or ≥12 months. No MRSA isolates were resistant to vancomycin or gentamicin. While over 85 % of MRSA isolates tested for fourth-generation fluoroquinolones were resistant, just 10 % MSSA isolates tested were resistant. There was a trend suggesting an increase in the proportion of MRSA isolates compared to MSSA isolates over the course of the study period.
  
  
  CONCLUSIONS
  There was no statistical difference in short- or long-term VA outcomes between the MRSA and MSSA groups at any time point. Resistance to fourth-generation fluoroquinolones was present in over 85 % of MRSA isolates, but just 10 % of MSSA isolates. An increasing proportion of MRSA amongst S. aureus isolates was noted over the course of the study period.
authors.affiliation: Institute of Ophthalmology and Visual Science, Rutgers-New Jersey Medical School, Newark, NJ, USA.|New York University School of Medicine, New York, NY, USA.
authors.forename: Jonathan I
authors.initials: JI
authors.lastname: Huz
authors.affiliation: Vitreous Retina Macula Consultants of New York, 460 Park Avenue, New York, NY, 10022, USA.
authors.forename: Krishna
authors.initials: K
authors.lastname: Mukkamala
authors.affiliation: New York University School of Medicine, New York, NY, USA.
authors.forename: Ivelisse Rodriguez
authors.initials: IR
authors.lastname: Pagan
authors.affiliation: New York Eye and Ear Infirmary of Mount Sinai, New York, NY, USA.
authors.forename: David
authors.initials: D
authors.lastname: Ritterband
authors.affiliation: New York Eye and Ear Infirmary of Mount Sinai, New York, NY, USA.
authors.forename: Mahendra
authors.initials: M
authors.lastname: Shah
authors.affiliation: New York Eye and Ear Infirmary of Mount Sinai, New York, NY, USA.
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Gentile
authors.affiliation: New York University School of Medicine, New York, NY, USA. michael.engelbert@gmail.com.|Vitreous Retina Macula Consultants of New York, 460 Park Avenue, New York, NY, 10022, USA. michael.engelbert@gmail.com.
authors.forename: Michael
authors.initials: M
authors.lastname: Engelbert
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D009877:Endophthalmitis / Q000188:drug therapy / Q000382:microbiology*; D015818:Eye Infections, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008712:Methicillin / Q000627:therapeutic use*; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D008712:Methicillin
keywords: Antibiotic sensitivity; Endophthalmitis; Retinal disorders; Staphylococcus aureus