title: Lower circulating insulin-like growth factor-I is associated with better cognition in females with exceptional longevity without compromise to muscle mass and function.
abstract: Mutations that reduce somatotropic signaling result in improved lifespan and health-span in model organisms and humans. However, whether reduced circulating insulin-like growth factor-I (IGF-I) level is detrimental to cognitive and muscle function in older adults remains understudied. A cross-sectional analysis was performed in Ashkenazi Jews with exceptional longevity (age ≥95 years). Cognition was assessed using the Mini-Mental State Examination and muscle function with the chair rise test, grip-strength, and gait speed. Muscle mass was estimated using the skeletal muscle index. Serum IGF-I was measured with liquid chromatography mass spectrometry. In gender stratified age-adjusted logistic regression analysis, females with IGF-I levels in the first tertile had lower odds of being cognitively impaired compared to females with IGF-I levels within the upper two tertiles, OR (95% CI) 0.39 (0.19-0.82). The result remained significant after adjustment for multiple parameters. No significant association was identified in males between IGF-I and cognition. No relationship was found between IGF-I tertiles and muscle function and muscle mass in females or males. Lower circulating IGF-I is associated with better cognitive function in females with exceptional longevity, with no detriment to skeletal muscle mass and function.
authors.affiliation: Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Leland
authors.initials: L
authors.lastname: Perice
authors.affiliation: Department of Medicine, Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA.|Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Nir
authors.initials: N
authors.lastname: Barzilai
authors.affiliation: Department of Medicine, Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA.|Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Joe
authors.initials: J
authors.lastname: Verghese
authors.affiliation: Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Erica F
authors.initials: EF
authors.lastname: Weiss
authors.affiliation: Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.|Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY 10461.
authors.forename: Roee
authors.initials: R
authors.lastname: Holtzer
authors.affiliation: Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
authors.forename: Pinchas
authors.initials: P
authors.lastname: Cohen
authors.affiliation: Department of Medicine, Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Sofiya
authors.initials: S
authors.lastname: Milman
mesh_terms: D000369:Aged, 80 and over; D003071:Cognition / Q000502:physiology*; D003430:Cross-Sectional Studies; D005260:Female; D005684:Gait / Q000502:physiology; D018737:Hand Strength / Q000502:physiology*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008136:Longevity / Q000502:physiology*; D008297:Male; D018482:Muscle, Skeletal / Q000502:physiology*; D009483:Neuropsychological Tests
chemical_list: D007334:Insulin-Like Growth Factor I
keywords: IGF-I; cognition; exceptional longevity; females; insulin-like growth factor-1