title: Fosfomycin for UTIs.
abstract: Fosfomycin trometamol is a broad spectrum antibiotic recently marketed in the UK for the treatment of acute uncomplicated lower urinary tract infections (UTIs) in adults1,2and in adult and adolescent females.3It is also indicated for prophylaxis in diagnostic and surgical transurethral procedures.1-3Fosfomycin was discovered in 1969 and the reference drug was first marketed as Monuril in France in 1986.3,4Although Monuril had UK marketing authorisation, it was never distributed in the UK. However, national guidance included the option of using unlicensed imported fosfomycin.3,5,6Branded and generic versions of fosfomycin are now available in the UK,1-3,7and here we review the evidence for their use in the treatment of UTIs.
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use; D000075202:Contraindications; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects; D005578:Fosfomycin / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D005578:Fosfomycin