title: [Respiratory viral infections in a cohort of children during the first year of life and their role in the development of wheezing].
abstract: BACKGROUND
  It is known that infants with viral respiratory infections severe enough to require hospital admission have a high risk of developing recurrent wheezing. Few data have been published on unselected populations. The main aim of this study was to analyse symptomatic and asymptomatic respiratory viral infections during the first year of life in a cohort of infants, recruited at birth, and the development of recurrent wheezing.
  
  
  METHODS
  A total of 302 newborns were recruited. A nasopharyngeal aspirate was taken when the patients had a respiratory infection, as well as in the visits for vaccination at 2, 4, 6, and 12 months. RT-nested PCR assays were performed to detect 16 viruses.
  
  
  RESULTS
  A total of 1,293 samples were analysed (1,005 healthy controls and 288 respiratory infections). Samples taken during routine check-ups were positive in 30.8% of cases, while those with respiratory infection were positive in 77.8%, P<.001 (OR: 3, 95% CI: 2.4-3.8). A total of 239 (79%) infants had at least 1 positive respiratory viral infection detected. The most frequent virus (71%) was rhinovirus (RV). Recurrent wheezing was found in 27 (11%) children during their first year of life (1.2 episodes, SD 2.9). Recurrent wheezing was present in 58.3% of patients admitted to hospital during their first viral infection, vs. 8.6% of infants when the first infection was mild or who had asymptomatic viral detection, P<.001 (OR: 2.18; 95% CI: 1.05-4.5).
  
  
  CONCLUSIONS
  In our series, severe respiratory infections leading to hospitalisation in the first months of life are risk factors for developing wheezing, but not in the case of mild RV infections.
authors.affiliation: Servicio de Pediatría, Hospital Severo Ochoa, Leganés, Madrid, España. Electronic address: ccalvorey@ono.com.
authors.forename: Cristina
authors.initials: C
authors.lastname: Calvo
authors.affiliation: Servicio de Pediatría, Hospital Severo Ochoa, Leganés, Madrid, España.
authors.forename: Isabel
authors.initials: I
authors.lastname: Aguado
authors.affiliation: Servicio de Pediatría, Hospital Severo Ochoa, Leganés, Madrid, España.
authors.forename: María Luz
authors.initials: ML
authors.lastname: García-García
authors.affiliation: Centro de Salud María Jesús Hereza, Leganés, Madrid, España.
authors.forename: Esther
authors.initials: E
authors.lastname: Ruiz-Chercoles
authors.affiliation: Centro de Salud Jaime Vera, Leganés, Madrid, España.
authors.forename: Eloisa
authors.initials: E
authors.lastname: Díaz-Martinez
authors.affiliation: Centro de Salud Cuzco, Fuenlabrada, Madrid, España.
authors.forename: Rosa María
authors.initials: RM
authors.lastname: Albañil
authors.affiliation: Centro de Salud Leganés Norte, Leganés, Madrid, España.
authors.forename: Olga
authors.initials: O
authors.lastname: Campelo
authors.affiliation: Centro de Salud Cuzco, Fuenlabrada, Madrid, España.
authors.forename: Antonio
authors.initials: A
authors.lastname: Olivas
authors.affiliation: Centro de Salud María Ángeles Gómez López, Leganés, Madrid, España.
authors.forename: Luisa
authors.initials: L
authors.lastname: Muñóz-Gonzalez
authors.affiliation: Laboratorio de Gripe y Virus Respiratorios, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, España.
authors.forename: Francisco
authors.initials: F
authors.lastname: Pozo
authors.affiliation: Centro de Salud Jaime Vera, Leganés, Madrid, España.
authors.forename: Rosa
authors.initials: R
authors.lastname: Fernandez-Arroyo
authors.affiliation: Servicio de Pediatría, Hospital Severo Ochoa, Leganés, Madrid, España.
authors.forename: Adelaida
authors.initials: A
authors.lastname: Fernandez-Rincón
authors.affiliation: Laboratorio de Gripe y Virus Respiratorios, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, España.
authors.forename: Ana
authors.initials: A
authors.lastname: Calderon
authors.affiliation: Laboratorio de Gripe y Virus Respiratorios, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, España.
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Casas
mesh_terms: D015331:Cohort Studies; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011446:Prospective Studies; D012008:Recurrence; D012135:Respiratory Sounds / Q000209:etiology*; D012141:Respiratory Tract Infections / Q000150:complications* / Q000821:virology*
keywords: Asymptomatic infections; Infants; Infecciones asintomáticas; Infecciones respiratorias; Infecciones virales; Lactantes; Respiratory infections; Rhinovirus; Rinovirus; Sibilancias; Viral infections; Wheezing