title: A review of the role of synaptosomal-associated protein 25 (SNAP-25) in neurological disorders.
abstract: Synaptosomal-associated protein 25 kDa (SNAP-25) is one of the key proteins involved in the formation of neural soluble N-ethylmaleimide-sensitive factor attachment protein receptor complexes, which are responsible for the calcium-dependent exocytosis of neurotransmitters - a major step in neurotransmission and the key to normal functioning of brain. Several studies have reported abnormalities in its expression and structure and highlighted it as an important player in pathology of various neurological disorders like Alzheimer's disease, schizophrenia, attention deficient hyperactivity disorder, epilepsy and few others. Several studies have also associated its substantial expression disturbances with various polymorphisms and post-translational modifications. The present review examines the crucial implication of SNAP-25 in altered neuronal processes and highlights its substantial association with various neurological disorders.
authors.affiliation: a Neurobiology Research Laboratory, Department of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences , National University of Sciences and Technology , Islamabad , Pakistan.
authors.forename: Aneeqa
authors.initials: A
authors.lastname: Noor
authors.affiliation: a Neurobiology Research Laboratory, Department of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences , National University of Sciences and Technology , Islamabad , Pakistan.
authors.forename: Saadia
authors.initials: S
authors.lastname: Zahid
mesh_terms: D001921:Brain / Q000473:pathology; D006801:Humans; D009422:Nervous System Diseases / Q000378:metabolism* / Q000473:pathology; D009474:Neurons / Q000378:metabolism; D050825:Synaptosomal-Associated Protein 25 / Q000378:metabolism*
chemical_list: C494208:SNAP25 protein, human; D050825:Synaptosomal-Associated Protein 25
keywords: Alzheimer's disease; Parkinson's disease; SNAP-25; epilepsy; schizophrenia