title: Challenges of Fracture Management for Adults With Osteogenesis Imperfecta.
abstract: Osteogenesis imperfecta is caused by qualitative or quantitative defects in type I collagen. Although often considered a disease with primarily pediatric manifestations, more than 25% of lifetime fractures are reported to occur in adulthood. General care of adults with osteogenesis imperfecta involves measures to preserve bone density, regular monitoring of hearing and dentition, and maintenance of muscle strength through physical therapy. Surgical stabilization of fractures in these patients can be challenging because of low bone mineral density, preexisting skeletal deformities, or obstruction by instrumentation from previous surgeries. Additionally, unique perioperative considerations exist when operatively managing fractures in patients with osteogenesis imperfecta. To date, there is little high-quality literature to help guide the optimal treatment of fractures in adult patients with osteogenesis imperfecta. [Orthopedics. 2017; 40(1):e17-e22.].
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Gil
authors.forename: Steven F
authors.initials: SF
authors.lastname: DeFroda
authors.forename: Kunal
authors.initials: K
authors.lastname: Sindhu
authors.forename: Aristides I
authors.initials: AI
authors.lastname: Cruz
authors.forename: Alan H
authors.initials: AH
authors.lastname: Daniels
mesh_terms: D000328:Adult; D015519:Bone Density; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D002118:Calcium / Q000627:therapeutic use; D024042:Collagen Type I; D005592:Fracture Fixation / Q000379:methods*; D050723:Fractures, Bone / Q000209:etiology / Q000601:surgery*; D006801:Humans; D053580:Muscle Strength; D019637:Orthopedic Procedures; D010013:Osteogenesis Imperfecta / Q000150:complications / Q000628:therapy*; D026741:Physical Therapy Modalities; D014807:Vitamin D / Q000627:therapeutic use
chemical_list: D050071:Bone Density Conservation Agents; D024042:Collagen Type I; D014807:Vitamin D; D002118:Calcium