title: T-cell Activation and E-selectin Are Associated With Coronary Plaque in HIV-infected Young Adults.
abstract: We evaluated immune activation and coronary artery plaque in young adults with human immunodeficiency virus acquired in early life (n = 31). Coronary plaque was positively associated with lipids, immune activation marker %CD8+CD38+DR+ and E-selectin, a marker of endothelial inflammation. Immune activation and endothelial inflammation may drive coronary plaque formation during the early stages of atherosclerosis in the context of chronic human immunodeficiency virus.
authors.affiliation: From the *Laboratory of Immunoregulation, National Institute of Allergy and Infectious Disease (NIAID), Bethesda, Maryland; †Critical Care Medicine Department, National Institutes of Health (NIH) Clinical Center, Bethesda, Maryland; ‡Biomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, Maryland; §AIDS Monitoring Laboratories, Frederick National Laboratory for Cancer Research Leidos Biomedical Research, Inc., Frederick, Maryland; and ¶Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, Maryland.
authors.forename: Aviva S
authors.initials: AS
authors.lastname: Mattingly
authors.forename: Aylin B
authors.initials: AB
authors.lastname: Unsal
authors.forename: Julia B
authors.initials: JB
authors.lastname: Purdy
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Gharib
authors.forename: Adam
authors.initials: A
authors.lastname: Rupert
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Kovacs
authors.forename: Dorothea
authors.initials: D
authors.lastname: McAreavey
authors.forename: Rohan
authors.initials: R
authors.lastname: Hazra
authors.forename: Khaled Z
authors.initials: KZ
authors.lastname: Abd-Elmoniem
authors.forename: Colleen
authors.initials: C
authors.lastname: Hadigan
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count; D016516:CD4-CD8 Ratio; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D023921:Coronary Stenosis / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D019040:E-Selectin / Q000097:blood; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D008297:Male; D058226:Plaque, Atherosclerotic; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D019040:E-Selectin