title: A new sarasinoside congener, sarasinoside M2, from a marine sponge collected in the Solomon Islands.
abstract: A new sarasinoside congener (sarasinoside M2) and known sarasinoside B1were obtained from a marine sponge. Sarasinoside M2was suggested to have the same aglycon as sarasinoside M although the internal glucose in its sugar moiety is replaced by xylose. Sarasinosides B1and M2showed moderate cytotoxicity (approximate IC505-18 μM) toward Neuro-2a and HepG2 cell lines.
authors.affiliation: a Graduate School of Agricultural Science, Tohoku University , Sendai , Japan.
authors.forename: Clyde Gorapava
authors.initials: CG
authors.lastname: Puilingi
authors.affiliation: a Graduate School of Agricultural Science, Tohoku University , Sendai , Japan.
authors.forename: Yuta
authors.initials: Y
authors.lastname: Kudo
authors.affiliation: a Graduate School of Agricultural Science, Tohoku University , Sendai , Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Cho
authors.affiliation: a Graduate School of Agricultural Science, Tohoku University , Sendai , Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Konoki
authors.affiliation: a Graduate School of Agricultural Science, Tohoku University , Sendai , Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Yotsu-Yamashita
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D008542:Melanesia; D051379:Mice; D011161:Porifera / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D006027:Glycosides
keywords: MS/MS; cytotoxicity; marine sponge; saponin; sarasinoside M2