title: Biologically active γ-lactams: synthesis and natural sources.
abstract: The γ-lactam moiety is present in a large number of natural and non-natural biologically active compounds. The range of biological activities covered by these compounds is very broad. Functionalized γ-lactams are thus of high interest and have great potential in medicinal chemistry. This review provides a description of the title compounds by focusing on their synthesis, natural sources and biological activities.
authors.affiliation: Institute of Condensed Matter and Nanosciences, Université catholique de Louvain, Place Louis Pasteur 1 box L4.01.02, 1348 Louvain-la-Neuve, Belgium. raphael.robiette@uclouvain.be and Louvain Drug Research Institute, Université catholique de Louvain, Av. E. Mounier 73 box B1.72.01, 1200 Brussels, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Caruano
authors.affiliation: Louvain Drug Research Institute, Université catholique de Louvain, Av. E. Mounier 73 box B1.72.01, 1200 Brussels, Belgium.
authors.forename: G G
authors.initials: GG
authors.lastname: Muccioli
authors.affiliation: Institute of Condensed Matter and Nanosciences, Université catholique de Louvain, Place Louis Pasteur 1 box L4.01.02, 1348 Louvain-la-Neuve, Belgium. raphael.robiette@uclouvain.be.
authors.forename: R
authors.initials: R
authors.lastname: Robiette
mesh_terms: D000478:Alkylation; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D003500:Cyclization; D007769:Lactams / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D001688:Biological Products; D007769:Lactams