title: Advances in Understanding Air Pollution and CVD.
abstract: The MESA Air (Multi-Ethnic Study of Atherosclerosis and Air Pollution) leveraged the platform of the MESA cohort into a prospective longitudinal study of relationships between air pollution and cardiovascular health. MESA Air researchers developed fine-scale, state-of-the-art air pollution exposure models for the MESA Air communities, creating individual exposure estimates for each participant. These models combine cohort-specific exposure monitoring, existing monitoring systems, and an extensive database of geographic and meteorological information. Together with extensive phenotyping in MESA-and adding participants and health measurements to the cohort-MESA Air investigated environmental exposures on a wide range of outcomes. Advances by the MESA Air team included not only a new approach to exposure modeling, but also biostatistical advances in addressing exposure measurement error and temporal confounding. The MESA Air study advanced our understanding of the impact of air pollutants on cardiovascular disease and provided a research platform for advances in environmental epidemiology.
authors.affiliation: Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA; Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA; Department of Medicine, University of Washington, Seattle, WA, USA. Electronic address: joelk@u.washington.edu.
authors.forename: Joel D
authors.initials: JD
authors.lastname: Kaufman
authors.affiliation: Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA.
authors.forename: Elizabeth W
authors.initials: EW
authors.lastname: Spalt
authors.affiliation: Department of Community and Environmental Health, College of Health Sciences, Boise State University, Boise, ID, USA.
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Curl
authors.affiliation: Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
authors.forename: Anjum
authors.initials: A
authors.lastname: Hajat
authors.affiliation: Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
authors.forename: Miranda R
authors.initials: MR
authors.lastname: Jones
authors.affiliation: Institute of Health and Environment, Seoul National University, Seoul, Korea.
authors.forename: Sun-Young
authors.initials: SY
authors.lastname: Kim
authors.affiliation: Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA.
authors.forename: Sverre
authors.initials: S
authors.lastname: Vedal
authors.affiliation: Department of Biostatistics, University of Washington, Seattle, WA, USA.
authors.forename: Adam A
authors.initials: AA
authors.lastname: Szpiro
authors.affiliation: Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA.
authors.forename: Amanda
authors.initials: A
authors.lastname: Gassett
authors.affiliation: Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA; Department of Biostatistics, University of Washington, Seattle, WA, USA.
authors.forename: Lianne
authors.initials: L
authors.lastname: Sheppard
authors.affiliation: Institute for Minority Health Research, University of Illinois at Chicago, Chicago, IL, USA; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: Martha L
authors.initials: ML
authors.lastname: Daviglus
authors.affiliation: Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Sara D
authors.initials: SD
authors.lastname: Adar
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000393:Air Pollutants / Q000009:adverse effects / Q000032:analysis; D000397:Air Pollution / Q000009:adverse effects*; D050197:Atherosclerosis / Q000139:chemically induced* / Q000453:epidemiology / Q000208:ethnology; D056808:Biostatistics; D002318:Cardiovascular Diseases / Q000139:chemically induced / Q000453:epidemiology / Q000208:ethnology; D002947:Cities; D004781:Environmental Exposure; D004782:Environmental Health; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D012959:Socioeconomic Factors; D014481:United States / Q000453:epidemiology
chemical_list: D000393:Air Pollutants