title: DIAGNOSTIC ACCURACY OF BARIUM ENEMA FINDINGS IN HIRSCHSPRUNG'S DISEASE.
abstract: Hirschsprung's disease is the most common cause of pediatric intestinal obstruction. Contrast enema is used for evaluation of the patients with its diagnosis.
  
  
  
  To evaluate sensitivity, specificity, positive predictive value, and negative predictive value of radiologic findings for diagnosis of Hirschsprung in patients underwent barium enema.
  
  
  
  This cross sectional study was carried out in Imam Khomeini Hospital for one year starting from 2012, April. Sixty patients were enrolled. Inclusion criteria were: neonates with failure to pass meconium, abdominal distention, and refractory constipation who failed to respond with medical treatment. Transitional zone, delay in barium evacuation after 24 h, rectosigmoid index (maximum with of the rectum divided by maximum with of the sigmoid; abnormal if <1), and irregularity of mucosa (jejunization) were evaluated in barium enema. Biopsy was obtained at three locations apart above dentate line. PPV, NPV, specificity , and sensitivity was calculated for each finding.
  
  
  
  Mean age of the cases with Hirschsprung's disease and without was 17.90±18.29 months and 17.8±18.34 months respectively (p=0.983). It was confirmed in 30 (M=20, F=10) of cases. Failure to pass meconium was found in 21(70%) cases. Sensitivity, specificity, PPV, and NPV were 90%, 80%, 81.8% and 88.8% respectively for transitional zone in barium enema. Sensitivity, specificity, PPV, and NPV were 76.7%, 83.3%, 78.1% and 82.1% respectively for rectosigmoid index .Sensitivity, specificity, PPV, and NPV were 46.7%, 100%, 100% and 65.2% respectively for irregular contraction detected in barium enema. Sensitivity, specificity, PPV, and NPV were 23.3%, 100%, 100% and 56.6% respectively for mucosal irregularity in barium enema.
  
  
  
  The most sensitive finding was transitional zone. The most specific findings were irregular contraction, mucosal irregularity, and followed by cobblestone appearance.
authors.affiliation: Department of Pediatric Surgery, Imam Khomeini Hospital, Iran.
authors.forename: Mehran
authors.initials: M
authors.lastname: Peyvasteh
authors.affiliation: Department of Pediatric Surgery, Imam Khomeini Hospital, Iran.
authors.forename: Shahnam
authors.initials: S
authors.lastname: Askarpour
authors.affiliation: Department of Pediatric Surgery, Imam Khomeini Hospital, Iran.
authors.forename: Nasrollah
authors.initials: N
authors.lastname: Ostadian
authors.affiliation: Department of Pediatric Surgery, Imam Khomeini Hospital, Iran.
authors.forename: Mohammad-Reza
authors.initials: MR
authors.lastname: Moghimi
authors.affiliation: Nursing Care Research Center in Chronic Diseases and Department of Pediatric Gastroenterology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Hazhir
authors.initials: H
authors.lastname: Javaherizadeh
mesh_terms: D000071941:Barium Enema; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006627:Hirschsprung Disease / Q000000981:diagnostic imaging*; D006801:Humans; D007223:Infant; D008297:Male; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity