title: Array-CGH predicts prognosis in plasma cell post-transplantation lymphoproliferative disorders.
abstract: Plasma-cell post-transplantation lymphoproliferative disorder (PC-PTLD) is a rare monomorphic PTLD entity divided into plasma cell myeloma (PCM) and plasmacytoma-like lesion (PLL) PTLD. To date, there are no exhaustive published cytogenetic data on PC-PTLD. We report array-based comparative genomic hybridization (aCGH) of 10 cases of PCM and PLL-PTLD. Patients had received kidney (n = 6), heart (n = 2), lung (n = 1) or bone marrow (n = 1) transplantation. There were six men and median age at time of PTLD was 56.5 years (3-74). We identified two different cytological features, plasmacytic and plasmablastic, among six PLL and three PCM PTLD. Eight cases were associated with EBV. First line treatment was heterogeneous: rituximab alone (n = 5), CHOP-like (n = 3) and multiple myeloma-like (n = 1). One patient died before any treatment. After a median follow-up of 19.5 months (0-150), five patients died (four from PTLD) and five were alive without evidence of disease. By aCGH, 5/10 demonstrated a complex profile. The most frequent abnormalities were +7q (5/10), +16q (5/10), +17q (5/10), +17p (4/10), +5q (4/10), t7 (4/10), t9 (3/10), del1p (3/10). No del17p13 (TP53) were observed. Del1p32.3 (CDKN2C) was observed in 2 cases. On univariate prognostic analysis, a complex aCGH was associated with a shorter OS. Thus, cytogenetic abnormalities seem to be closely related to those reported in multiple myeloma or diffuse large B cell lymphoma. Complex aCGH constitutes an unfavorable prognostic marker and aCGH should be integrated in the evaluation of patients with PLL/PCM-PTLD. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Service d'Hématologie, Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, Pierre Bénite cedex, 69495, France.|INSERM1052, CNRS 5286, Université Claude Bernard, Faculté de Médecine Lyon-Sud Charles Mérieux Lyon-1, Pierre Bénite cedex, 69495, France.
authors.forename: Clémentine
authors.initials: C
authors.lastname: Sarkozy
authors.affiliation: Laboratoire de cytogénétique, Hôpital Necker - Enfants Malades, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Descartes Sorbonne Cité, Paris, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Kaltenbach
authors.affiliation: Centre Léon Bérard, service d'Hématologie, Université Claude Bernard Lyon 1, Lyon, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Faurie
authors.affiliation: Service de Pathologie, Hôpital Necker - Enfants Malades, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Descartes Sorbonne Cité, Paris, France.|Institut Necker-Enfants Malades (INEM), Institut national de recherche médicale (INSERM) UMR1151/CNRS8253, Université Paris Descartes Sorbonne Cité, Paris, France.
authors.forename: Danielle
authors.initials: D
authors.lastname: Canioni
authors.affiliation: Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, Service de Pathologie, Lyon, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Berger
authors.affiliation: Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, Service de Pathologie, Lyon, France.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Traverse-Glehen
authors.affiliation: INSERM1052, CNRS 5286, Université Claude Bernard, Faculté de Médecine Lyon-Sud Charles Mérieux Lyon-1, Pierre Bénite cedex, 69495, France.|Centre Léon Bérard, service d'Hématologie, Université Claude Bernard Lyon 1, Lyon, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Ghesquieres
authors.affiliation: Service d'Hématologie, Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, Pierre Bénite cedex, 69495, France.|INSERM1052, CNRS 5286, Université Claude Bernard, Faculté de Médecine Lyon-Sud Charles Mérieux Lyon-1, Pierre Bénite cedex, 69495, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Salles
authors.affiliation: Service d'Hématologie, Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, Pierre Bénite cedex, 69495, France.|INSERM1052, CNRS 5286, Université Claude Bernard, Faculté de Médecine Lyon-Sud Charles Mérieux Lyon-1, Pierre Bénite cedex, 69495, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Bachy
authors.affiliation: Laboratoire d'Immunologie, Hôpital Necker - Enfants Malades, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Descartes Sorbonne Cité, Paris, France.
authors.forename: Marie-Alexandra
authors.initials: MA
authors.lastname: Alyanakian
authors.affiliation: Service d'Hématologie Adulte, Hôpital Necker - Enfants Malades, Assistance Publique - Hôpitaux de Paris (APHP), Université Paris Descartes Sorbonne Cité, Paris, France.|Inserm U1163/CNRS ERL8254, Institut Imagine (Lab 215-217), Site Hôpital Necker - Enfants Malades, Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Hermine
authors.affiliation: Service d'Immuno-Hématologie Pédiatrique, Hôpital Necker - Enfants Malades, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Descartes Sorbonne Cité, Paris France.
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Neven
authors.affiliation: Institut Necker-Enfants Malades (INEM), Institut national de recherche médicale (INSERM) UMR1151/CNRS8253, Université Paris Descartes Sorbonne Cité, Paris, France.|Laboratoire d'Onco-Hématologie, Hôpital Necker - Enfants Malades, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Descartes Sorbonne Cité, Paris, France.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Macintyre
authors.affiliation: Laboratoire de cytogénétique, Hôpital Necker - Enfants Malades, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Descartes Sorbonne Cité, Paris, France.
authors.forename: Serge
authors.initials: S
authors.lastname: Romana
authors.affiliation: Service de Pathologie, Hôpital Necker - Enfants Malades, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Descartes Sorbonne Cité, Paris, France.
authors.forename: Thierry Jo
authors.initials: TJ
authors.lastname: Molina
authors.affiliation: Service d'Hématologie Adulte, Hôpital Necker - Enfants Malades, Assistance Publique - Hôpitaux de Paris (APHP), Université Paris Descartes Sorbonne Cité, Paris, France.|Inserm U1163/CNRS ERL8254, Institut Imagine (Lab 215-217), Site Hôpital Necker - Enfants Malades, Paris, France.
authors.forename: Felipe
authors.initials: F
authors.lastname: Suarez
authors.affiliation: Institut Necker-Enfants Malades (INEM), Institut national de recherche médicale (INSERM) UMR1151/CNRS8253, Université Paris Descartes Sorbonne Cité, Paris, France.|Laboratoire d'Onco-Hématologie, Hôpital Necker - Enfants Malades, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Descartes Sorbonne Cité, Paris, France.
authors.forename: Vahid
authors.initials: V
authors.lastname: Asnafi
authors.affiliation: Service de Pathologie, Hôpital Necker - Enfants Malades, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Descartes Sorbonne Cité, Paris, France.|Inserm U1163/CNRS ERL8254, Institut Imagine (Lab 215-217), Site Hôpital Necker - Enfants Malades, Paris, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Bruneau
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D055028:Comparative Genomic Hybridization / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016377:Organ Transplantation / Q000009:adverse effects*; D010950:Plasma Cells / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D015996:Survival Rate; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor