title: Asymptomatic Herpes Simplex Virus Infection in Iranian Mothers and Their Newborns.
abstract: This study aims to determine the prevalence of herpes simplex virus (HSV) infection among pregnant women as well as congenital infection of their newborns in Tehran. One hundred samples of blood sera from pregnant women were analyzed for the presence of HSV specific antibodies. Umbilical cord blood samples from the newborns were analyzed for the presence of HSV DNA using real-time PCR. HSV IgG and IgM antibodies were found in 97% and 2% of pregnant women, respectively. Of all the 100 cord blood samples, 6 were positive for HSV DNA in which 2 cases were from mothers who had detectable IgM. It was notable that all corresponding mothers of six HSV positive infants had detectable IgG antibodies in their sera. It was demonstrated that the presence of HSV DNA in cord blood of newborns could be a risk marker for maternal-fetal transmission of the virus in asymptomatic pregnant women.
authors.affiliation: a Department of Medical Virology , Iran University of Medical Sciences , Tehran , Iran.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Tavakoli
authors.affiliation: a Department of Medical Virology , Iran University of Medical Sciences , Tehran , Iran.
authors.forename: Seyed Hamidreza
authors.initials: SH
authors.lastname: Monavari
authors.affiliation: a Department of Medical Virology , Iran University of Medical Sciences , Tehran , Iran.
authors.forename: Farah
authors.initials: F
authors.lastname: Bokharaei-Salim
authors.affiliation: a Department of Medical Virology , Iran University of Medical Sciences , Tehran , Iran.
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Mollaei
authors.affiliation: b Human Viral Vaccine Department , Razi Vaccine and Serum Research Institute , Karaj , Iran.
authors.forename: Bahman
authors.initials: B
authors.lastname: Abedi-Kiasari
authors.affiliation: c Department of Pediatrics Disease, Loghman Hakim Hospital , Shahid Beheshti University of Medical Sciences , Tehran , Iran.
authors.forename: Fatemeh Hoda
authors.initials: FH
authors.lastname: Fallah
authors.affiliation: a Department of Medical Virology , Iran University of Medical Sciences , Tehran , Iran.
authors.forename: Helya Sadat
authors.initials: HS
authors.lastname: Mortazavi
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D004279:DNA, Viral / Q000302:isolation & purification; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005312:Fetal Blood; D006561:Herpes Simplex / Q000175:diagnosis* / Q000635:transmission* / Q000821:virology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007231:Infant, Newborn; D007492:Iran; D009035:Mothers; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis*; D060888:Real-Time Polymerase Chain Reaction; D018139:Simplexvirus; D016896:Treatment Outcome
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M
keywords: Herpes simplex virus; antibodies; congenital disease; cord blood; real-time PCR