title: Visualizing the nanoscale: protein internal dynamics and neutron spin echo spectroscopy.
abstract: The most complex molecular machines are proteins found within cells. Protein dynamics, in particular dynamics on nanoscales, presents us with a novel paradigm for cell signaling: the idea that proteins and protein complexes can communicate directly within themselves to effect long-range information transfer, via coupled domains and correlated residue clusters. This idea has been little explored, in large part because of a paucity of experimental techniques that can address the necessary questions. Here we review recent progress in developing a promising new approach, neutron spin echo spectroscopy.
authors.affiliation: Department of Chemistry and Biochemistry, City College of New York, PhD Programs in Chemistry and Biochemistry, CUNY, United States.
authors.forename: David Je
authors.initials: DJ
authors.lastname: Callaway
authors.affiliation: Department of Chemistry and Biochemistry, City College of New York, PhD Programs in Chemistry and Biochemistry, CUNY, United States. Electronic address: dcallaway@ccny.cuny.edu.
authors.forename: Zimei
authors.initials: Z
authors.lastname: Bu
mesh_terms: D000494:Allosteric Regulation; D009068:Movement; D036103:Nanotechnology / Q000379:methods*; D009502:Neutrons; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D013057:Spectrum Analysis / Q000379:methods*
chemical_list: D011506:Proteins