title: Outcomes Evaluation of Zero-Profile Devices Compared to Stand-Alone PEEK Cages for the Treatment of Three- and Four-Level Cervical Disc Disease.
abstract: BACKGROUND
  Anterior cervical discectomy and fusion (ACDF) is a well-accepted treatment option for patients with cervical spine disease. Three- and four-level discectomies are known to be associated with a higher complication rate and lower fusion rate than single-level surgery. This study was performed to evaluate and compare zero-profile fixation and stand-alone PEEK cages for three- and four-level ACDF.
  
  
  METHODS
  Two cohorts of patients who underwent ACDF for the treatment of three- and four-level disease were compared. Thirty-three patients underwent implantation of zero-profile devices that included titanium screw fixation (Group A). Thirty-five patients underwent implantation of stand-alone PEEK cages without any form of screw fixation (Group B).
  
  
  RESULTS
  In Group A, twenty-seven patients underwent a three-level and six patients a four-level ACDF, with a total of 105 levels. In Group B, thirty patients underwent a three-level and five patients underwent a four-level ACDF, with a total number of 110 levels. In Group A, the mean preoperative visual analog scale score (VAS) for arm pain was 6.4 (range 3-8), and the mean postoperative VAS for arm pain decreased to 2.5 (range 1-7). In group B, the mean preoperative VAS of arm pain was 7.1 (range 3-10), and the mean postoperative VAS of arm pain decreased to 2 (range 0-4). In Group A, four patients (12%) developed dysphagia, and in Group B, three patients (9%) developed dysphagia.  Conclusions: This study found zero-profile instrumentation and PEEK cages to be both safe and effective for patients who underwent three- and four-level ACDF, comparable to reported series using plate devices. Rates of dysphagia for the cohort were much lower than reports using plate devices. Zero-profile segmental fixation devices and PEEK cages may be considered as viable alternatives over plate fixation for patients requiring multi-level anterior cervical fusion surgery.
authors.affiliation: Department of Neurological Surgery, University of Pittsburgh Medical Center.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Gerszten
authors.affiliation: Department of Neurological Surgery, University of Pittsburgh Medical Center.
authors.forename: Erin
authors.initials: E
authors.lastname: Paschel
authors.affiliation: Ain Shams University.
authors.forename: Hazem
authors.initials: H
authors.lastname: Mashaly
authors.affiliation: Ain Shams University.
authors.forename: Hatem
authors.initials: H
authors.lastname: Sabry
authors.affiliation: Ain Shams University.
authors.forename: Hasan
authors.initials: H
authors.lastname: Jalalod'din
authors.affiliation: Ain Shams University.
authors.forename: Khaled
authors.initials: K
authors.lastname: Saoud
keywords: anterior cervical discectomy and fusion; cervical spine; disc herniation; spinal fusion; zero-profile