title: A Metabolic Roadblock in Inflammatory Macrophages.
abstract: In this issue of Cell Reports, Van den Bossche et al. (2016) reveal that, once the M1 macrophage forms, the accompanying metabolic alterations in the mitochondria are irreversible, preventing differentiation into the more homeostatic M2 macrophage.
authors.affiliation: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin 2, Ireland. Electronic address: laoneill@tcd.ie.
authors.forename: Luke A J
authors.initials: LA
authors.lastname: O'Neill
mesh_terms: D000818:Animals; D016764:Cell Polarity / Q000187:drug effects; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D015847:Interleukin-4 / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology*; D051379:Mice
chemical_list: D015847:Interleukin-4