title: Processing and strengthening of 58S bioactive glass-infiltrated titania scaffolds.
abstract: In this work, TiO2ceramic scaffolds were fabricated by the replica method using polyurethane (PU) sponges. Suspensions with high solid content were used to achieve scaffolds with improved mechanical behavior. TiO2ceramic suspensions were optimized by rheological studies using different additives. It was found that the composition with 0.5 wt % Darvan enhanced the covering of the sponge struts. PU sponges of 45 to 80 ppi (pore per inch) were well coated without clogging pores. A thermal treatment with varying holding times, temperatures and heating rates was adjusted. The influence of different pore sizes on mechanical strength was evaluated. It was possible to obtain TiO2scaffolds with 90% porosity and high pore interconnectivity, having compressive strength exceeding 0.6 MPa. TiO2scaffolds were filled up with a 58S bioactive glass suspension to impart bioactive character to the scaffolds. These hybrid structures presented mechanical strengthening of about 26-213% depending on their sponge porosity. The prediction for cells viability via zeta potential measures indicated that this hybrid material is very promising for scaffold application with -19 to -25 mV between pH of 7.35-7.45. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 590-600, 2017.
authors.affiliation: Department of Mechanical Engineering (EMC), Federal University of Santa Catarina (UFSC), Florianópolis, SC, Brazil.|Center for Microelectromechanical Systems (CMEMS-UMinho), University of Minho, Azurém, Guimarães, Portugal.
authors.forename: J
authors.initials: J
authors.lastname: Mesquita-Guimarães
authors.affiliation: Department of Mechanical Engineering (EMC), Federal University of Santa Catarina (UFSC), Florianópolis, SC, Brazil.
authors.forename: M A
authors.initials: MA
authors.lastname: Leite
authors.affiliation: Center for Microelectromechanical Systems (CMEMS-UMinho), University of Minho, Azurém, Guimarães, Portugal.|Center for Research on Dental Implants (CEPID), School of Dentistry (ODT), Federal University of Santa Catarina (UFSC), Florianópolis, SC, Brazil.
authors.forename: J C M
authors.initials: JC
authors.lastname: Souza
authors.affiliation: Department of Mechanical Engineering (EMC), Federal University of Santa Catarina (UFSC), Florianópolis, SC, Brazil.|Center for Microelectromechanical Systems (CMEMS-UMinho), University of Minho, Azurém, Guimarães, Portugal.
authors.forename: B
authors.initials: B
authors.lastname: Henriques
authors.affiliation: Center for Microelectromechanical Systems (CMEMS-UMinho), University of Minho, Azurém, Guimarães, Portugal.
authors.forename: F S
authors.initials: FS
authors.lastname: Silva
authors.affiliation: Department of Mechanical Engineering (EMC), Federal University of Santa Catarina (UFSC), Florianópolis, SC, Brazil.
authors.forename: D
authors.initials: D
authors.lastname: Hotza
authors.affiliation: Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Erlangen, Germany.
authors.forename: A R
authors.initials: AR
authors.lastname: Boccaccini
authors.affiliation: Department of Mechanical Engineering (EMC), Federal University of Santa Catarina (UFSC), Florianópolis, SC, Brazil.
authors.forename: M C
authors.initials: MC
authors.lastname: Fredel
mesh_terms: D005898:Glass / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D016062:Porosity; D013314:Stress, Mechanical; D054457:Tissue Scaffolds / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*
chemical_list: C448994:bioactive glass 58S; C009495:titanium dioxide; D014025:Titanium
keywords: bioactive glass; hybrid scaffolds; mechanical properties; titanium dioxide; zeta potential