title: Photocaging of Single and Dual (Similar or Different) Carboxylic and Amino Acids by Acetyl Carbazole and its Application as Dual Drug Delivery in Cancer Therapy.
abstract: A new fluorescent photoremovable protecting group (FPRPG) based on acetylcarbazole framework has been explored for the first time release of single and dual (similar or different) substrates from single chromophore. Mechanistic studies of the photorelease process revealed that photorelease of two (similar or different) substrates from acetyl carbazole proceeds via a stepwise pathway. Further, we constructed photoresponsive dual drug delivery system (DDS) to release two different anticancer drugs (caffeic acid and chlorambucil, 1 equiv each). In vitro study reveals that our DDS exhibit excellent properties like biocompatibility, cellular uptake, and photoregulated dual drug release.
authors.affiliation: Department of Chemistry, ‡School of Medical Science and Technology, Indian Institute of Technology Kharagpur , 721302 West Bengal, India.|Biomaterials Group, ⊥Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology , Hyderabad 500007, India.
authors.forename: Yarra
authors.initials: Y
authors.lastname: Venkatesh
authors.affiliation: Department of Chemistry, ‡School of Medical Science and Technology, Indian Institute of Technology Kharagpur , 721302 West Bengal, India.|Biomaterials Group, ⊥Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology , Hyderabad 500007, India.
authors.forename: Y
authors.initials: Y
authors.lastname: Rajesh
authors.affiliation: Department of Chemistry, ‡School of Medical Science and Technology, Indian Institute of Technology Kharagpur , 721302 West Bengal, India.|Biomaterials Group, ⊥Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology , Hyderabad 500007, India.
authors.forename: S
authors.initials: S
authors.lastname: Karthik
authors.affiliation: Department of Chemistry, ‡School of Medical Science and Technology, Indian Institute of Technology Kharagpur , 721302 West Bengal, India.|Biomaterials Group, ⊥Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology , Hyderabad 500007, India.
authors.forename: A C
authors.initials: AC
authors.lastname: Chetan
authors.affiliation: Department of Chemistry, ‡School of Medical Science and Technology, Indian Institute of Technology Kharagpur , 721302 West Bengal, India.|Biomaterials Group, ⊥Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology , Hyderabad 500007, India.
authors.forename: Mahitosh
authors.initials: M
authors.lastname: Mandal
authors.affiliation: Department of Chemistry, ‡School of Medical Science and Technology, Indian Institute of Technology Kharagpur , 721302 West Bengal, India.|Biomaterials Group, ⊥Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology , Hyderabad 500007, India.
authors.forename: Avijit
authors.initials: A
authors.lastname: Jana
authors.affiliation: Department of Chemistry, ‡School of Medical Science and Technology, Indian Institute of Technology Kharagpur , 721302 West Bengal, India.|Biomaterials Group, ⊥Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology , Hyderabad 500007, India.
authors.forename: N D Pradeep
authors.initials: ND
authors.lastname: Singh
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002227:Carbazoles / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D009369:Neoplasms / Q000188:drug therapy*; D010777:Photochemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000596:Amino Acids; D002227:Carbazoles; D002264:Carboxylic Acids