title: Retrospective study of adjuvant icotinib in postoperative lung cancer patients harboring epidermal growth factor receptor mutations.
abstract: BACKGROUND
  Epidermal growth factor receptor (EGFR) mutations occur in about 50% of Asian patients with non-small cell lung cancer (NSCLC). Patients with advanced NSCLC and EGFR mutations derive clinical benefit from treatment with EGFR-tyrosine kinase inhibitors (TKIs). This study assessed the efficacy and safety of adjuvant icotinib without chemotherapy in EGFR-mutated NSCLC patients undergoing resection of stage IB-IIIA.
  
  
  METHODS
  Our retrospective study enrolled 20 patients treated with icotinib as adjuvant therapy. Survival factors were evaluated by univariate and Cox regression analysis.
  
  
  RESULTS
  The median follow-up time was 30 months (range 24-41). At the data cut-off, five patients (25%) had recurrence or metastasis and one patient had died of the disease. The two-year disease-free survival (DFS) rate was 85%. No recurrence occurred in the high-risk stage IB subgroup during the follow-up period. In univariate analysis, the micropapillary pattern had a statistically significant effect on DFS ( P = 0.040). Multivariate logistic regression analysis showed that there was no independent predictor. Drug related adverse events (AEs) occurred in nine patients (45.0%). The most common AEs were skin-related events and diarrhea, but were relatively mild. No grade 3 AEs or occurrences of intolerable toxicity were observed.
  
  
  CONCLUSIONS
  Icotinib as adjuvant therapy is effective in patients harboring EGFR mutations after complete resection, with an acceptable AE profile. Further trials with larger sample sizes might confirm the efficiency of adjuvant TKI in selected patients.
authors.affiliation: Department of Thoracic Surgery, Xuan Wu Hospital, Capital Medical University, Beijing, China.
authors.forename: Shuyang
authors.initials: S
authors.lastname: Yao
authors.affiliation: Department of Thoracic Surgery, Xuan Wu Hospital, Capital Medical University, Beijing, China.
authors.forename: Xiuyi
authors.initials: X
authors.lastname: Zhi
authors.affiliation: Department of Thoracic Surgery, Xuan Wu Hospital, Capital Medical University, Beijing, China.
authors.forename: Ruotian
authors.initials: R
authors.lastname: Wang
authors.affiliation: Department of Thoracic Surgery, Xuan Wu Hospital, Capital Medical University, Beijing, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Qian
authors.affiliation: Department of Thoracic Surgery, Xuan Wu Hospital, Capital Medical University, Beijing, China.
authors.forename: Mu
authors.initials: M
authors.lastname: Hu
authors.affiliation: Department of Thoracic Surgery, Xuan Wu Hospital, Capital Medical University, Beijing, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000235:genetics / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D043844:Crown Ethers / Q000008:administration & dosage* / Q000009:adverse effects; D018572:Disease-Free Survival; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009367:Neoplasm Staging; D011799:Quinazolines / Q000008:administration & dosage* / Q000009:adverse effects; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D043844:Crown Ethers; D011799:Quinazolines; C531470:icotinib; C512478:EGFR protein, human; D066246:ErbB Receptors
keywords: Adjuvant therapy; epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI); non-small cell lung cancer (NSCLC)