title: [Wound healing is still a game of " blind men and an elephant"].
abstract: The wound healing includes non-healing and overhealing of the wounds. The results of wound healing are well known by people such as non-healing of the diabetic ulcer or hypertrophic scar after deep burn. In this issue, three papers involve in wound healing, one about autologous adipose-derived mesenchymal stem cells injected into wound or scar of rabbit ear, one about severe hypoxia and hypoalbuminemia inducing human hypertrophic scar derived fibroblast apoptosis in vitro, and another about the dysfunction of protein kinase B/mammalian target of rapamycin signaling pathway contributing to the pathophysiological characteristics of diabetic skin and non-healing wound. The basic problem of hypertrophic scar study is lacking an ideal animal model. Although rabbit ear model or red Duroc pig model has been used widely for study on hypertrophic scar, they can not fully represent human dermal fibrosis after deep trauma on the skin. I recommendA novel nude mouse model of hypertrophic scarring using scratched full thickness human skin graftsrecently published inAdvances in Wound Careto the readers. The author emphasizes that the wound healing study is still in the situation like the game of " blind men and an elephant" .
authors.affiliation: Department of Burns, the Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou 310009, China.
authors.forename: C M
authors.initials: CM
authors.lastname: Han
mesh_terms: D000818:Animals; D002056:Burns; D017439:Cicatrix, Hypertrophic; D004195:Disease Models, Animal; D005355:Fibrosis; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D011817:Rabbits; D012867:Skin; D016038:Skin Transplantation; D014945:Wound Healing