title: Vitamin D in hematological disorders and malignancies.
abstract: Commonly known for its critical role in calcium homeostasis and bone mineralization, more recently vitamin D has been implicated in hematological cancer pathogenesis and shows promise as an anti-cancer therapy. Serum levels of 25(OH)D3, the precursor to the active form of vitamin D, calcitriol, are frequently lower in patients with hematological disease compared to healthy individuals. This often correlates with worse disease outcome. Furthermore, diseased cells typically highly express the vitamin D receptor, which is required for many of the anti-cancer effects observed in multiple in vivo and in vitro cancer models. In abnormal hematological cells, vitamin D supplementation promotes apoptosis, induces differentiation, inhibits proliferation, sensitizes tumor cells to other anti-cancer therapies, and reduces the production of pro-inflammatory cytokines. Although the dosage of vitamin D required to achieve these effects may induce hypercalcemia in humans, analogs and combinatorial treatments have been developed to circumvent this side effect. Vitamin D and its analogs are well tolerated in clinical trials, and thus, further investigation into the use of these agents in the clinic is warranted. Here, we review the current literature in this field.
authors.affiliation: University of Virginia Cancer Center, University of Virginia, Charlottesville, VA, USA.|Division of Hematology/Oncology, Department of Medicine, University of Virginia, Charlottesville, VA, USA.|Department of Pathology, University of Virginia, Charlottesville, VA, USA.
authors.forename: Paige M
authors.initials: PM
authors.lastname: Kulling
authors.affiliation: University of Virginia Cancer Center, University of Virginia, Charlottesville, VA, USA.|Division of Hematology/Oncology, Department of Medicine, University of Virginia, Charlottesville, VA, USA.
authors.forename: Kristine C
authors.initials: KC
authors.lastname: Olson
authors.affiliation: University of Virginia Cancer Center, University of Virginia, Charlottesville, VA, USA.|Division of Hematology/Oncology, Department of Medicine, University of Virginia, Charlottesville, VA, USA.
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Olson
authors.affiliation: University of Virginia Cancer Center, University of Virginia, Charlottesville, VA, USA.|Division of Hematology/Oncology, Department of Medicine, University of Virginia, Charlottesville, VA, USA.
authors.forename: David J
authors.identifier: http://orcid.org/0000-0003-4981-1691
authors.initials: DJ
authors.lastname: Feith
authors.affiliation: University of Virginia Cancer Center, University of Virginia, Charlottesville, VA, USA.|Division of Hematology/Oncology, Department of Medicine, University of Virginia, Charlottesville, VA, USA.
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Loughran
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D019008:Drug Resistance, Neoplasm; D004357:Drug Synergism; D006402:Hematologic Diseases / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism*; D019337:Hematologic Neoplasms / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism*; D006801:Humans; D007107:Immune System / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D053612:Janus Kinases / Q000378:metabolism; D018167:Receptors, Calcitriol / Q000235:genetics / Q000378:metabolism; D050791:STAT Transcription Factors / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D014807:Vitamin D / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D018167:Receptors, Calcitriol; D050791:STAT Transcription Factors; D014807:Vitamin D; D053612:Janus Kinases
keywords: 25(OH)D3; aplastic anemia; calcitriol; immune cells; leukemia; lymphoma; vitamin D; vitamin D receptor