title: Clinical insights for early detection of acute transverse myelitis in the emergency department.
abstract: OBJECTIVE
  Acute transverse myelitis (ATM) is characterized by motor weakness, sensory changes, and autonomic dysfunction. However, diagnosis of ATM is based on early-stage clinical features only (and clarification of the cause of disease), which are difficult for emergency department (ED) physicians owing to low incidence rates. We performed retrospective analysis of ATM in order to provide clinical insights for early detection.
  
  
  METHODS
  Medical records of patients, who were finally diagnosed with ATM from January 2005 to February 2013, were investigated. Data, including demographics, clinical findings, and radiographic findings, were reviewed.
  
  
  RESULTS
  Forty-six patients were included in the present study, with a mean age of 43.4 years. Sensory changes were identified in 45 patients (97.8%), motor weakness in 33 patients (71.7%), and autonomic dysfunction in 35 patients (76.1%). Thirty patients (65.2%) showed high signal intensity in T2-weighted magnetic resonance imaging (MRI), with lesions most frequently found in the thoracic level of the spinal cord (56.7%). There were discrepancies between sensory changes and levels of MRI lesions. Thirty-five patients (76.1%) were diagnosed with idiopathic ATM. Initial diagnostic impressions in the ED were herniated intervertebral disc (38.7%), stroke (19.4%), Guillain-Barré syndrome (12.9%), cauda equina syndrome (9.7%), ATM (9.7%), and others (9.7%).
  
  
  CONCLUSIONS
  When a patient presents with motor weakness, sensory changes, or autonomic dysfunction, ATM should be initially considered as a differential diagnosis, unless the ED physician's impression after initial evaluation is clear.
authors.affiliation: Department of Emergency Medicine, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Yo
authors.initials: Y
authors.lastname: Huh
authors.affiliation: Department of Emergency Medicine, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Eun-Jung
authors.initials: EJ
authors.lastname: Park
authors.affiliation: Department of Emergency Medicine, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Ju-Won
authors.initials: JW
authors.lastname: Jung
authors.affiliation: Department of Emergency Medicine, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Sungho
authors.initials: S
authors.lastname: Oh
authors.affiliation: Department of Emergency Medicine, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Sang-Cheon
authors.initials: SC
authors.lastname: Choi
keywords: Diagnosis; Emergency service, hospital; Myelitis, transverse