title: A negative relationship between ventral striatal loss anticipation response and impulsivity in borderline personality disorder.
abstract: Patients with borderline personality disorder (BPD) frequently exhibit impulsive behavior, and self-reported impulsivity is typically higher in BPD patients when compared to healthy controls. Previous functional neuroimaging studies have suggested a link between impulsivity, the ventral striatal response to reward anticipation, and prediction errors. Here we investigated the striatal neural response to monetary gain and loss anticipation and their relationship with impulsivity in 21 female BPD patients and 23 age-matched female healthy controls using functional magnetic resonance imaging (fMRI). Participants performed a delayed monetary incentive task in which three categories of objects predicted a potential gain, loss, or neutral outcome. Impulsivity was assessed using the Barratt Impulsiveness Scale (BIS-11). Compared to healthy controls, BPD patients exhibited significantly reduced fMRI responses of the ventral striatum/nucleus accumbens (VS/NAcc) to both reward-predicting and loss-predicting cues. BIS-11 scores showed a significant positive correlation with the VS/NAcc reward anticipation responses in healthy controls, and this correlation, while also nominally positive, failed to reach significance in BPD patients. BPD patients, on the other hand, exhibited a significantly negative correlation between ventral striatal loss anticipation responses and BIS-11 scores, whereas this correlation was significantly positive in healthy controls. Our results suggest that patients with BPD show attenuated anticipation responses in the VS/NAcc and, furthermore, that higher impulsivity in BPD patients might be related to impaired prediction of aversive outcomes.
authors.affiliation: Leibniz Institute for Neurobiology, Magdeburg, Germany; Department of Psychiatry and Psychotherapy, Campus Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Berlin, Germany; Department of Psychology, Humboldt University, Berlin, Germany.
authors.forename: Maike C
authors.initials: MC
authors.lastname: Herbort
authors.affiliation: Leibniz Institute for Neurobiology, Magdeburg, Germany; Bernstein Center for Computational Neuroscience, Humboldt University, Berlin, Germany.
authors.forename: Joram
authors.initials: J
authors.lastname: Soch
authors.affiliation: Department of Psychiatry and Psychotherapy, Campus Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Torsten
authors.initials: T
authors.lastname: Wüstenberg
authors.affiliation: Department of Child and Adolescent Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany; Center for Behavioral Brain Sciences, Magdeburg, Germany.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Krauel
authors.affiliation: Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.
authors.forename: Maia
authors.initials: M
authors.lastname: Pujara
authors.affiliation: Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Koenigs
authors.affiliation: Department of Psychiatry and Psychotherapy, Campus Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, University Hospital Eppendorf, Hamburg, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Gallinat
authors.affiliation: Department of Psychiatry and Psychotherapy, Campus Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Henrik
authors.initials: H
authors.lastname: Walter
authors.affiliation: Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Roepke
authors.affiliation: Leibniz Institute for Neurobiology, Magdeburg, Germany; Department of Psychiatry and Psychotherapy, Campus Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany; Center for Behavioral Brain Sciences, Magdeburg, Germany.
authors.forename: Björn H
authors.initials: BH
authors.lastname: Schott
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001883:Borderline Personality Disorder / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000503:physiopathology*; D016022:Case-Control Studies; D003463:Cues; D001068:Feeding and Eating Disorders / Q000453:epidemiology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007175:Impulsive Behavior / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D019964:Mood Disorders / Q000453:epidemiology; D009042:Motivation / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D011594:Psychometrics; D011930:Reaction Time / Q000502:physiology; D019966:Substance-Related Disorders / Q000453:epidemiology; D066328:Ventral Striatum / Q000000981:diagnostic imaging*; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: Borderline personality disorder; Brain-behavior correlations; Functional magnetic resonance imaging; Impulsivity; Loss; Monetary incentive delay; Reward