title: Accuracy of Acoustic Analysis Measurements in the Evaluation of Patients With Different Laryngeal Diagnoses.
abstract: OBJECTIVE
  This study aims to investigate the accuracy of acoustic measures in discriminating between patients with different laryngeal diagnoses.
  
  
  METHODS
  The study design is descriptive, cross-sectional, and retrospective.
  
  
  METHODS
  A total of 279 female patients participated in the research. Acoustic measures of the mean and standard deviation (SD) values of the fundamental frequency (F0), jitter, shimmer, and glottal to noise excitation (GNE) were extracted from the emission of the vowel /ε/.
  
  
  RESULTS
  Isolated acoustic measures do not demonstrate adequate performance in discriminating patients with and without laryngeal alteration. The combination of GNE, SD of the F0, jitter, and shimmer improved the ability to classify patients with and without laryngeal alteration. In isolation, the SD of the F0, shimmer, and GNE presented acceptable performance in discriminating individuals with different laryngeal diagnoses. The combination of acoustic measurements caused discrete improvement in performance of the classifier to discriminate healthy larynx vs vocal polyp (SD of the F0, shimmer, and GNE), healthy larynx vs unilateral vocal fold paralysis (SD of the F0and jitter), healthy larynx vs vocal nodules (SD of the F0and jitter), healthy larynx vs sulcus vocalis (SD of the F0and shimmer), and healthy larynx vs voice disorder due to gastroesophageal reflux (F0mean, jitter, and shimmer).
  
  
  CONCLUSIONS
  Isolated acoustic measures do not demonstrate adequate performance in discriminating patients with and without laryngeal alteration, although they present acceptable performance in classifying different laryngeal diagnoses. Combined acoustic measures present an acceptable capacity to discriminate between the presence and the absence of laryngeal alteration and to differentiate several laryngeal diagnoses.
authors.affiliation: Speech and Language Pathology Department, Universidade Federal da Paraíba-UFPB, João Pessoa, PB, Brazil. Electronic address: lwlopes@hotmail.com.
authors.forename: Leonardo Wanderley
authors.initials: LW
authors.lastname: Lopes
authors.affiliation: Speech and Language Pathology Department, Universidade Federal da Paraíba-UFPB, João Pessoa, PB, Brazil.
authors.forename: Layssa
authors.initials: L
authors.lastname: Batista Simões
authors.affiliation: Speech and Language Pathology Department, Universidade Federal da Paraíba-UFPB, João Pessoa, PB, Brazil.
authors.forename: Jocélio
authors.initials: J
authors.lastname: Delfino da Silva
authors.affiliation: Speech and Language Pathology Department, Universidade Federal da Paraíba-UFPB, João Pessoa, PB, Brazil.
authors.forename: Deyverson
authors.initials: D
authors.lastname: da Silva Evangelista
authors.affiliation: Speech and Language Pathology Department, Centro Universitário de João Pessoa-UNIPÊ, João Pessoa, PB, Brazil.
authors.forename: Ana Celiane
authors.initials: AC
authors.lastname: da Nóbrega E Ugulino
authors.affiliation: Speech and Language Pathology Department, Universidade Federal da Paraíba-UFPB, João Pessoa, PB, Brazil.
authors.forename: Priscila
authors.initials: P
authors.lastname: Oliveira Costa Silva
authors.affiliation: Electrical Engineering Department, Universidade Federal de Campina Grande-UFCG, Campina Grande, PB, Brazil.
authors.forename: Vinícius
authors.initials: V
authors.lastname: Jefferson Dias Vieira
mesh_terms: D000162:Acoustics; D000293:Adolescent; D000328:Adult; D003430:Cross-Sectional Studies; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007818:Laryngeal Diseases / Q000145:classification / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D007830:Larynx / Q000503:physiopathology*; D008875:Middle Aged; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012815:Signal Processing, Computer-Assisted; D013061:Speech Acoustics; D014832:Voice Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D014833:Voice Quality; D055815:Young Adult
keywords: Accuracy; Acoustic analysis; Larynx; Voice; Voice disorder