title: Inflammatory regulation of stem-like cells in melanoma.
abstract: The link between inflammation, immunity and cancer is well established. In the last decade, there has been considerable excitement over cancer stem cells, believed to be a subset of tumour cells responsible for their initiation, propagation and resistance to conventional chemoradiotherapy. In this review, we discuss the characterization of cancer stem cells and describe their modulation by inflammation with a focus on melanoma.
authors.affiliation: Departments of aAcademic Surgery bMedical Oncology, University College Cork, Cork University Hospital, Cork, Ireland.
authors.forename: Ming-Sheng
authors.initials: MS
authors.lastname: Lim
authors.forename: Jiang Huai
authors.initials: JH
authors.lastname: Wang
authors.forename: Derek G
authors.initials: DG
authors.lastname: Power
authors.forename: H Paul
authors.initials: HP
authors.lastname: Redmond
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D019008:Drug Resistance, Neoplasm; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D008545:Melanoma / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism*; D051739:Microphthalmia-Associated Transcription Factor / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D014411:Neoplastic Stem Cells / Q000276:immunology* / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D010641:Phenotype; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D048493:Proto-Oncogene Proteins B-raf / Q000037:antagonists & inhibitors; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D017475:Receptors, Nerve Growth Factor / Q000378:metabolism; D051880:Receptors, Notch / Q000378:metabolism; D015398:Signal Transduction; D019139:Tumor Escape; D059016:Tumor Microenvironment
chemical_list: D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D051739:Microphthalmia-Associated Transcription Factor; D016328:NF-kappa B; D009419:Nerve Tissue Proteins; D019869:Phosphatidylinositol 3-Kinases; D047428:Protein Kinase Inhibitors; D048493:Proto-Oncogene Proteins B-raf; D051057:Proto-Oncogene Proteins c-akt; D017475:Receptors, Nerve Growth Factor; D051880:Receptors, Notch; C480744:ABCB5 protein, human; C484065:NGFR protein, human