title: The ART and science of sperm mitophagy.
abstract: This article discusses the historical perspective and the new findings of autophagy and ubiquitin-proteasome system cooperation during the post-fertilization sperm mitophagy, a process that eliminates potentially damaged paternal mitochondrial DNA from an early embryo. New insight into the mechanism that promotes clonal, maternal inheritance of mitochondrial genes may be helpful for managing mitochondrial disease and infertility in humans, as well as reproductive performance and production traits in agriculturally important domestic animals.
authors.affiliation: a Division of Animal Sciences , Gynecology and Women's Health, University of Missouri , Columbia , MO , USA.
authors.forename: Won-Hee
authors.initials: WH
authors.lastname: Song
authors.affiliation: a Division of Animal Sciences , Gynecology and Women's Health, University of Missouri , Columbia , MO , USA.
authors.forename: Young-Joo
authors.initials: YJ
authors.lastname: Yi
authors.affiliation: a Division of Animal Sciences , Gynecology and Women's Health, University of Missouri , Columbia , MO , USA.
authors.forename: Miriam
authors.initials: M
authors.lastname: Sutovsky
authors.affiliation: c Department of Anatomy, Physiology, and Cell Biology , School of Veterinary Medicine, University of California Davis , Davis , CA , USA.
authors.forename: Stuart
authors.initials: S
authors.lastname: Meyers
authors.affiliation: a Division of Animal Sciences , Gynecology and Women's Health, University of Missouri , Columbia , MO , USA.|b Department of Obstetrics , Gynecology and Women's Health, University of Missouri , Columbia , MO , USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Sutovsky
mesh_terms: D000818:Animals; D001343:Autophagy; D006801:Humans; D008297:Male; D063306:Mitophagy; D008954:Models, Biological; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D013094:Spermatozoa / Q000378:metabolism*; D034421:Sus scrofa; D025801:Ubiquitin / Q000378:metabolism; D015053:Zygote / Q000166:cytology
chemical_list: D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex
keywords: SQSTM1; VCP; assisted reproductive therapy; autophagy; mitochondria; mitophagy; mtDNA; ubiquitin-proteasome system