title: Pharmacokinetic evaluation of the interaction between oral kaempferol and ethanol in rats.
abstract: This study was aimed at investigating the effect of ethanol on oral bioavailability of kaempferol in rats, namely, at disclosing their possible interaction. Kaempferol (100 or 250 mg kg-1 bm) was administered to the rats by oral gavage with or without ethanol (600 mg kg-1 bm) co-administration. Intravenous administration (10 and 25 mg kg-1 bm) of kaempferol was used to determine the bioavailability. The concentration of kaempferol in plasma was estimated by ultra high performance liquid chromatography. During coadministration, a significant increase of the area under the plasma concentration-time curve as well as the peak concentration were observed, along with a dramatic decrease in total body clearance. Consequently, the bioavailability of kaempferol in oral control groups was 3.1 % (100 mg kg-1 bm) and 2.1 % (250 mg kg-1 bm). The first was increased by 4.3 % and the other by 2.8 % during ethanol co-administration. Increased permeability of cell membrane and ethanolkaempferol interactions on CYP450 enzymes may enhance the oral bioavailability of kaempferol in rats.
authors.forename: Zhaoxiang
authors.initials: Z
authors.lastname: Zhou
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.forename: Zengjun
authors.initials: Z
authors.lastname: Guo
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000284:Administration, Oral; D000428:Alcohol Drinking / Q000009:adverse effects* / Q000097:blood / Q000378:metabolism; D000434:Alcoholic Beverages / Q000009:adverse effects; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry / Q000493:pharmacokinetics*; D001682:Biological Availability; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000009:adverse effects; D018565:Food-Drug Interactions; D006207:Half-Life; D007275:Injections, Intravenous; D007408:Intestinal Absorption; D044949:Kaempferols / Q000008:administration & dosage / Q000819:agonists / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D008657:Metabolic Clearance Rate; D011897:Random Allocation; D017207:Rats, Sprague-Dawley
chemical_list: D000975:Antioxidants; D044949:Kaempferols; D000431:Ethanol; C006552:kaempferol