title: BDNF levels are increased in peripheral blood of middle-aged amateur runners with no changes on histone H4 acetylation levels.
abstract: Our aim was to compare the basal levels of plasma brain-derived neurotrophic factor (BDNF) and global histone H4 acetylation in peripheral blood mononuclear cells (PBMCs) of healthy amateur runners (EXE group) with sedentary individuals (SED group) as well as to investigate the acute effect of a running race on these markers in the EXE group. Five days before the race, all participants were submitted to a basal blood collection. On the race day, two blood samples were collected in the EXE group before the running started and immediately at the end. In the basal period, a significant increase of plasma BDNF levels in the EXE individuals when compared to the SED group (p = 0.036) was demonstrated, while no difference in global histone H4 acetylation levels was observed. These parameters were unaltered in the EXE group after the race. The increased levels of BDNF might be linked to healthy middle-aged runners' phenotype.
authors.affiliation: Programa de Pós Graduação em Biociências e Reabilitação do Centro Universitário Metodista do IPA, Rua Coronel Joaquim Pedro Salgado, 80-Rio Branco, Porto Alegre, Rio Grande do Sul, CEP 90420-060, Brazil.
authors.forename: Fernanda Peres
authors.initials: FP
authors.lastname: da Silveira
authors.affiliation: Programa de Pós Graduação Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
authors.forename: Carla
authors.initials: C
authors.lastname: Basso
authors.affiliation: Programa de Pós Graduação Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
authors.forename: Wagner
authors.initials: W
authors.lastname: Raupp
authors.affiliation: Programa de Pós Graduação em Biociências e Reabilitação do Centro Universitário Metodista do IPA, Rua Coronel Joaquim Pedro Salgado, 80-Rio Branco, Porto Alegre, Rio Grande do Sul, CEP 90420-060, Brazil.
authors.forename: Morgana
authors.initials: M
authors.lastname: Dalpiaz
authors.affiliation: Programa de Pós Graduação Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
authors.forename: Karine
authors.initials: K
authors.lastname: Bertoldi
authors.affiliation: Programa de Pós Graduação Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
authors.forename: Ionara Rodrigues
authors.initials: IR
authors.lastname: Siqueira
authors.affiliation: Programa de Pós Graduação em Ciências da Reabilitação, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.
authors.forename: Pedro Dal
authors.initials: PD
authors.lastname: Lago
authors.affiliation: Programa de Pós Graduação em Biociências e Reabilitação do Centro Universitário Metodista do IPA, Rua Coronel Joaquim Pedro Salgado, 80-Rio Branco, Porto Alegre, Rio Grande do Sul, CEP 90420-060, Brazil.
authors.forename: Maristela Padilha
authors.initials: MP
authors.lastname: de Souza
authors.affiliation: Programa de Pós Graduação em Biociências e Reabilitação do Centro Universitário Metodista do IPA, Rua Coronel Joaquim Pedro Salgado, 80-Rio Branco, Porto Alegre, Rio Grande do Sul, CEP 90420-060, Brazil. vivielsner.fisiologia@gmail.com.
authors.forename: Viviane Rostirola
authors.initials: VR
authors.lastname: Elsner
mesh_terms: D000107:Acetylation; D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood* / Q000378:metabolism; D016022:Case-Control Studies; D006657:Histones / Q000097:blood* / Q000378:metabolism; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012420:Running / Q000502:physiology*; D057185:Sedentary Behavior
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D006657:Histones; C579455:BDNF protein, human
keywords: Adult men; Epigenetic; Exercise; Neurotrophins; Peripheral blood mononuclear cells (PBMCs); Plasma