title: Theoretical Exploration of Type I/Type II Dual Photoreactivity of Promising Ru(II) Dyads for PDT Approach.
abstract: Ru(II) dyads are a class of bioactive molecules of interest as anticancer agents obtained incorporating an organic chromophore in the light-absorbing metallic scaffold. A careful DFT and TDDFT investigation of the photophysical properties of a series of Ru(II)-polypiridyl dyads containing polythiophene chains of different lengths bound to a coordinating imidazo[4,5-f][1,10]phenanthroline ligand is herein reported. The modulation of the crucial chemical and physical properties of the photosensitizer with increasing number of thiophene units has been accurately described by investigating the UV-vis spectra and type I and type II photoreactions, also including spin-orbit coupling values (SOC). Results show that the low-lying3IL states afforded as the number of thiophene ligands increases (n = 3, 4) are energetically high enough to ensure singlet oxygen production and can be also involved in electron transfer reaction, showing a dual type I/type II photeoreactivity.
authors.affiliation: Chimie ParisTech, PSL Research University, CNRS, Institut de Recherche de Chimie Paris (IRCP) , F-75005 Paris, France.
authors.forename: Marta Erminia
authors.initials: ME
authors.lastname: Alberto
authors.affiliation: Dipartimento di Chimica e Tecnologie Chimiche, Università della Calabria , Via P. Bucci, 87036 Rende, Italy.
authors.forename: Jenny
authors.initials: J
authors.lastname: Pirillo
authors.affiliation: Dipartimento di Chimica e Tecnologie Chimiche, Università della Calabria , Via P. Bucci, 87036 Rende, Italy.
authors.forename: Nino
authors.initials: N
authors.lastname: Russo
authors.affiliation: Chimie ParisTech, PSL Research University, CNRS, Institut de Recherche de Chimie Paris (IRCP) , F-75005 Paris, France.|Institut Universitaire de France , 103 Boulevard Saint Michel, F-75005 Paris, France.
authors.forename: Carlo
authors.initials: C
authors.lastname: Adamo
mesh_terms: D008024:Ligands; D008027:Light; D008958:Models, Molecular; D010618:Phenanthrolines / Q000737:chemistry*; D055668:Photochemical Processes; D017319:Photosensitizing Agents / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011789:Quantum Theory; D012428:Ruthenium / Q000737:chemistry*; D026082:Singlet Oxygen / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D013876:Thiophenes / Q000737:chemistry*
chemical_list: D008024:Ligands; D010618:Phenanthrolines; D017319:Photosensitizing Agents; D011108:Polymers; D013876:Thiophenes; D026082:Singlet Oxygen; C066730:polythiophene; D012428:Ruthenium