title: Juglone loaded poloxamer 188/phospholipid mixed micelles evaluated in vitro and in vivo in breast cancer.
abstract: OBJECTIVE
  Investigating the effects of juglone loaded P188/phospholipid mixed micelles (J-MM) in breast cancer.
  
  
  METHODS
  In vitro cytotoxicity, apoptotic effects, in vivo therapeutic efficacy and toxicity were used to assess its antitumour effect. Uptake and imaging were used to evaluate the effect on the uptake and passive targeting.
  
  
  RESULTS
  Mixed micelle carrier enhanced the targeting and uptake by MB-231 cells. The tumour inhibition rates in tumour xenograft models for paclitaxel, juglone, J-MM (10mg/kg) and J-MM (40mg/kg) were 46%, 27%, 39% and 53%, respectively. J-MM (10mg/kg) exhibited lower toxicity compared with that by free juglone or high dose J-MM.
  
  
  CONCLUSIONS
  J-MM exhibited low toxicity, improved cellular uptake, passive targeting and anti-cancer effects in breast cancer model.
authors.affiliation: Department of hospital pharmacy, The First Hospital of Suqian, 120 Suzhilu, Suqian 223800, China. Electronic address: jinxin871211@163.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Jin
authors.affiliation: Department of hospital pharmacy, The First Hospital of Suqian, 120 Suzhilu, Suqian 223800, China.
authors.forename: Youwen
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Jiangsu Province Hospital on Integration of Chinese and Western Medicine affiliated with Nanjing University of Chinese Medicine, 100 Shizijie, Nanjing 210028, China.
authors.forename: Zhenhai
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of hospital pharmacy, The First Hospital of Suqian, 120 Suzhilu, Suqian 223800, China.
authors.forename: Danbiao
authors.initials: D
authors.lastname: Che
authors.affiliation: Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China. Electronic address: lvhuixia@163.com.
authors.forename: Huixia
authors.initials: H
authors.lastname: Lv
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry; D005260:Female; D006801:Humans; D008823:Micelles; D009285:Naphthoquinones / Q000737:chemistry* / Q000494:pharmacology*; D017239:Paclitaxel / Q000737:chemistry / Q000494:pharmacology; D010743:Phospholipids / Q000737:chemistry*; D020442:Poloxamer / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008823:Micelles; D009285:Naphthoquinones; D010743:Phospholipids; D020442:Poloxamer; D017239:Paclitaxel; C005134:juglone
keywords: Antitumor; Juglone; Mixed micelles; Toxicity; Uptake