title: Critical Functions of the Lysosome in Cancer Biology.
abstract: Lysosomes (or lytic bodies) were so named because they contain high levels of hydrolytic enzymes. Lysosome function and dysfunction have been found to play important roles in human disease, including cancer; however, the ways in which lysosomes contribute to tumorigenesis and cancer progression are still being uncovered. Beyond serving as a cellular recycling center, recent evidence suggests that the lysosome is involved in energy homeostasis, generating building blocks for cell growth, mitogenic signaling, priming tissues for angiogenesis and metastasis formation, and activating transcriptional programs. This review examines emerging knowledge of how lysosomal processes contribute to the hallmarks of cancer and highlights vulnerabilities that might be exploited for cancer therapy.
authors.affiliation: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139; email: smd10@mit.edu , mvh@mit.edu.|Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
authors.forename: Shawn M
authors.initials: SM
authors.lastname: Davidson
authors.affiliation: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139; email: smd10@mit.edu , mvh@mit.edu.|Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.|Dana-Farber Cancer Institute, Boston, Massachusetts 02215.
authors.forename: Matthew G
authors.initials: MG
authors.lastname: Vander Heiden
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D006706:Homeostasis / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008247:Lysosomes / Q000235:genetics / Q000378:metabolism*; D009361:Neoplasm Invasiveness / Q000235:genetics; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*
chemical_list: D000970:Antineoplastic Agents
keywords: cancer; cancer metabolism; hallmarks of cancer; lysosome function