title: Predictive Factors of Idiopathic Thrombocytopenic Purpura and Long-term Survival in Chinese Adults Undergoing Laparoscopic Splenectomy.
abstract: The study aimed to investigate the long-term outcomes of laparoscopic splenectomy (LS) in Chinese patients with chronic idiopathic thrombocytopenic purpura (ITP). This was a retrospective analysis of 114 patients with ITP who underwent LS from 2001 to 2013. Patients were classified according to response at last contact: complete response (CR), partial response (PR), and no response (NR). Patients with CR had the highest platelet levels and patients with NR had the lowest. A correlation was observed between postoperative peak platelet count and platelet count on 2-month postoperative (r=0.829, P<0.01). In total, 27 patients showed NR to LS. Ten patients recurred within 3 years. The 140-month response rate to LS was 68%. Multivariate analysis showed that age and postoperative platelet count were independently associated with CR/PR. In conclusion, LS achieved good outcomes in Chinese patients with ITP. Age and postoperative peak platelet were independently associated with response.
authors.affiliation: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Xu
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Fa
authors.initials: F
authors.lastname: Jin
authors.forename: Keren
authors.initials: K
authors.lastname: Wu
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Ye
mesh_terms: D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology / Q000208:ethnology; D002908:Chronic Disease; D006801:Humans; D053208:Kaplan-Meier Estimate; D010535:Laparoscopy / Q000379:methods* / Q000401:mortality; D010976:Platelet Count; D011182:Postoperative Care; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000208:ethnology / Q000401:mortality / Q000601:surgery*; D012008:Recurrence; D012189:Retrospective Studies; D013156:Splenectomy / Q000379:methods* / Q000401:mortality; D016896:Treatment Outcome