title: Glycemic status and chronic kidney disease in Chinese adults: Findings from the REACTION study.
abstract: BACKGROUND
  Diagnosed diabetes has been associated with chronic kidney disease (CKD). However, the association between non-diabetic hyperglycemia and CKD remained uncertain. The aim of the present study was to investigate the association between different glycemic status and CKD in Chinese adults and to assess the prevalence and control of diabetes among individuals with CKD.
  
  
  METHODS
  In all, 250 752 adults aged ≥40 years were selected from the baseline cohort of the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal (REACTION) study. Plasma glucose concentrations and biochemical and other clinical data were collected; CKD was defined as an estimated glomerular filtration rate (eGFR) <60 mL/min per 1.73 m2.
  
  
  RESULTS
  The prevalence of CKD increased gradually with deterioration of glucose metabolic status in both men and women ( Ptrend< 0.001 for both). Compared with individuals with normal glucose regulation, men with prediabetes and diabetes had higher risks of prevalent CKD (prediabetes odds ratio [OR] 1.15, 95% confidence interval [CI] 1.02-1.32; newly diagnosed diabetes OR 1.27, 95% CI 1.08-1.49; previously diagnosed diabetes OR 2.05, 95% CI 1.78-2.35). Similar results were observed in women, but not among those with prediabetes. In male CKD patients with diabetes, 52.1% received antidiabetic treatment and 41.8% of those treated had effective glycemic control, higher than values for females.
  
  
  CONCLUSIONS
  Prediabetes and diabetes were associated with an increased risk of CKD in Chinese men. Control of diabetes among Chinese CKD patients is far from optimal.
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Lin
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authors.lastname: Lin
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Jieli
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authors.lastname: Lu
authors.affiliation: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Lulu
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authors.lastname: Chen
authors.affiliation: Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Yiming
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authors.lastname: Mu
authors.affiliation: Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
authors.forename: Zhen
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authors.lastname: Ye
authors.affiliation: Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China.
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authors.affiliation: Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China.
authors.forename: Gang
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authors.affiliation: Affiliated Hospital of Guiyang Medical College, Guiyang, China.
authors.forename: Lixin
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authors.affiliation: Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
authors.forename: Jiajun
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authors.lastname: Zhao
authors.affiliation: The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Qiang
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authors.affiliation: The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.
authors.forename: Tao
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authors.affiliation: Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Li
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authors.lastname: Yan
authors.affiliation: The Affiliated Hospital of Luzhou Medical College, Luzhou, China.
authors.forename: Qin
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authors.affiliation: Karamay Municipal People's Hospital, Xinjiang, China.
authors.forename: Shengli
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authors.lastname: Wu
authors.affiliation: The First Hospital of Jilin University, Changchun, China.
authors.forename: Yan
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authors.lastname: Liu
authors.affiliation: The First Hospital of Jilin University, Changchun, China.
authors.forename: Guixia
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authors.affiliation: The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
authors.forename: Zuojie
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authors.lastname: Luo
authors.affiliation: The First Hospital of Lanzhou University, Lanzhou, China.
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authors.affiliation: Jiangxi People's Hospital, Nanchang, China.
authors.forename: Yanan
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authors.lastname: Huo
authors.affiliation: Dalian Municipal Central Hospital, Dalian, China.
authors.forename: Zhengnan
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authors.affiliation: Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Qing
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authors.affiliation: The First Affiliated Hospital of Anhui Medical University, Hefei, China.
authors.forename: Youmin
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authors.affiliation: The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Guijun
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authors.affiliation: The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Huacong
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authors.lastname: Deng
authors.affiliation: Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Xuefeng
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authors.lastname: Yu
authors.affiliation: The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
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authors.affiliation: Qilu Hospital of Shandong University, Jinan, China.
authors.forename: Li
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authors.affiliation: National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
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authors.affiliation: National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
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authors.affiliation: National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
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authors.lastname: Xu
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Kui
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authors.lastname: Peng
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Rui
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authors.affiliation: National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Meng
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authors.affiliation: National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Mian
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authors.affiliation: National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Tiange
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authors.lastname: Wang
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Zhiyun
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authors.lastname: Zhao
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.|Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Shenghan
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authors.lastname: Lai
authors.affiliation: Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Donghui
authors.initials: D
authors.lastname: Li
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Yufang
authors.initials: Y
authors.lastname: Bi
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Weiqing
authors.initials: W
authors.lastname: Wang
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
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mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006943:Hyperglycemia / Q000453:epidemiology*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000453:epidemiology*; D015995:Prevalence; D011446:Prospective Studies; D011795:Surveys and Questionnaires
chemical_list: D001786:Blood Glucose
keywords: chronic kidney disease; diabetes; glycemic status; prediabetes; 慢性肾脏疾病; 糖代谢状态; 糖尿病; 糖尿病前期