title: Highly Dynamic Spatiotemporal Organization of Low-Frequency Activities During Behavioral States in the Mouse Cerebral Cortex.
abstract: Although low-frequency (LF < 10 Hz) activities have been considered as a hallmark of nonrapid eye movement (NREM) sleep, several studies have recently reported LF activities in the membrane potential of cortical neurons from different areas in awake mice. However, little is known about the spatiotemporal organization of LF activities across cortical areas during wakefulness and to what extent it differs during NREM sleep. We have thus investigated the dynamics of LF activities across cortical areas in awake and sleeping mice using chronic simultaneous local field potential recordings. We found that LF activities had higher amplitude in somatosensory and motor areas during quiet wakefulness and decreased in most areas during active wakefulness, resulting in a global state change that was overall correlated with motor activity. However, we also observed transient desynchronization of cortical states between areas, indicating a more local state regulation. During NREM sleep, LF activities had higher amplitude in all areas but slow-wave activity was only poorly correlated across cortical areas. Despite a maximal amplitude during NREM sleep, the coherence of LF activities between areas that are not directly connected dropped from wakefulness to NREM sleep, potentially reflecting a breakdown of long-range cortical integration associated with loss of consciousness.
authors.affiliation: INSERM U1028, CNRS UMR5292, Lyon Neuroscience Research Center, Integrative Physiology of the Brain Arousal System Team, Lyon Cedex 08 F-69000, France.|Lyon Neuroscience Research Center, University Lyon 1, Lyon Cedex 08 F-69000, France.
authors.forename: Laura M J
authors.initials: LMJ
authors.lastname: Fernandez
authors.affiliation: Lyon Neuroscience Research Center, University Lyon 1, Lyon Cedex 08 F-69000, France.|INSERM U1028, CNRS UMR5292, Lyon Neuroscience Research Center, Forgetting and Cortical Dynamics Team, Lyon Cedex 08 F-69000, France.|INSERM U1028, CNRS UMR5292, Lyon Neuroscience Research Center, Biphoton Microscopy, Lyon F-69000, France.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Comte
authors.affiliation: INSERM U1028, CNRS UMR5292, Lyon Neuroscience Research Center, Integrative Physiology of the Brain Arousal System Team, Lyon Cedex 08 F-69000, France.|Lyon Neuroscience Research Center, University Lyon 1, Lyon Cedex 08 F-69000, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Le Merre
authors.affiliation: INSERM U1028, CNRS UMR5292, Lyon Neuroscience Research Center, Integrative Physiology of the Brain Arousal System Team, Lyon Cedex 08 F-69000, France.|Lyon Neuroscience Research Center, University Lyon 1, Lyon Cedex 08 F-69000, France.
authors.forename: Jian-Sheng
authors.initials: JS
authors.lastname: Lin
authors.affiliation: Lyon Neuroscience Research Center, University Lyon 1, Lyon Cedex 08 F-69000, France.|INSERM U1028, CNRS UMR5292, Lyon Neuroscience Research Center, Forgetting and Cortical Dynamics Team, Lyon Cedex 08 F-69000, France.|INSERM U1028, CNRS UMR5292, Lyon Neuroscience Research Center, Biphoton Microscopy, Lyon F-69000, France.
authors.forename: Paul-A
authors.initials: PA
authors.lastname: Salin
authors.affiliation: INSERM U1028, CNRS UMR5292, Lyon Neuroscience Research Center, Integrative Physiology of the Brain Arousal System Team, Lyon Cedex 08 F-69000, France.|Lyon Neuroscience Research Center, University Lyon 1, Lyon Cedex 08 F-69000, France.|Laboratory of Sensory Processing, EPFL, Lausanne CH-1015, Switzerland.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Crochet
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D003243:Consciousness / Q000502:physiology; D003344:Cortical Synchronization / Q000502:physiology; D004567:Electrodes, Implanted; D008297:Male; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000502:physiology*; D012815:Signal Processing, Computer-Assisted; D012890:Sleep / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology*
keywords: NREM sleep; cortical dynamics; local field potential; long-range synchrony; wakefulness