title: Health-Related Quality of Life among Older Related Hematopoietic Stem Cell Donors (>60 Years) Is Equivalent to That of Younger Related Donors (18 to 60 Years): A Related Donor Safety Study.
abstract: The increasing number of older adults with blood-related disorders and the introduction of reduced-intensity conditioning regimens has led to increases in hematopoietic stem cell (HSC) transplantation among older adults and a corresponding increase in the age of siblings who donate HSCs to these patients. Data regarding the donation-related experiences of older donors are lacking. The Related Donor Safety Study aimed to examine/compare health-related quality of life (HRQoL) of older versus younger HSC donors. Sixty peripheral blood stem cell (PBSC) donors ages 18 to 60 years and 104 PBSC donors age >60 years completed validated questionnaires before donation and 4 weeks and 1 year after donation. Before donation, older donors had poorer general physical health (t = -3.27; P = .001) but better mental health (t = 2.11; P < .05). There were no age differences in multiple other donation-related factors. At 4 weeks after donation, there were no group differences in general physical/mental health, but older donors were less likely to report donation-related pain (t = -2.26; P < .05) and concerns (t = -3.38; P = .001). At both 4 weeks and 1 year after donation, there were no significant differences in the percentage of each age group feeling physically back to normal or in the number of days it took donors to feel completely well. There was no evidence that increasing age within the older donor group was associated with poorer donation-related HRQoL. Taken together, these data support the current practice of HSC donation by sibling donors above age 60, providing no evidence of worsening HRQoL up to 1 year after donation in individuals up to age 76.
authors.affiliation: Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Clinical and Translational Science, University of Pittsburgh, Pittsburgh, Pennsylvania; Center for Health Equity Research and Promotion, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania. Electronic address: SwitzerGE@upmc.edu.
authors.forename: Galen E
authors.initials: GE
authors.lastname: Switzer
authors.affiliation: Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.
authors.forename: Jessica
authors.initials: J
authors.lastname: Bruce
authors.affiliation: Center for International Blood and Marrow Transplant Research, National Marrow Donor Program/Be The Match®, Minneapolis, Minnesota.
authors.forename: Deidre M
authors.initials: DM
authors.lastname: Kiefer
authors.affiliation: Center for International Blood and Marrow Transplant Research, National Marrow Donor Program/Be The Match®, Minneapolis, Minnesota.
authors.forename: Hati
authors.initials: H
authors.lastname: Kobusingye
authors.affiliation: Center for International Blood and Marrow Transplant Research, National Marrow Donor Program/Be The Match®, Minneapolis, Minnesota.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Drexler
authors.affiliation: Center for International Blood and Marrow Transplant Research, National Marrow Donor Program/Be The Match®, Minneapolis, Minnesota.
authors.forename: RaeAnne M
authors.initials: RM
authors.lastname: Besser
authors.affiliation: Center for International Blood and Marrow Transplant Research, National Marrow Donor Program/Be The Match®, Minneapolis, Minnesota.
authors.forename: Dennis L
authors.initials: DL
authors.lastname: Confer
authors.affiliation: Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: Mary M
authors.initials: MM
authors.lastname: Horowitz
authors.affiliation: Center for International Blood and Marrow Transplant Research, National Marrow Donor Program/Be The Match®, Minneapolis, Minnesota.
authors.forename: Roberta J
authors.initials: RJ
authors.lastname: King
authors.affiliation: Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: Bronwen E
authors.initials: BE
authors.lastname: Shaw
authors.affiliation: Division of Hematology/Oncology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
authors.forename: Marcie
authors.initials: M
authors.lastname: Riches
authors.affiliation: Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.
authors.forename: Brandon
authors.initials: B
authors.lastname: Hayes-Lattin
authors.affiliation: Division of Hematology, University of Washington, Seattle, Washington.
authors.forename: Michael
authors.initials: M
authors.lastname: Linenberger
authors.affiliation: Cleveland Clinic Lerner School of Medicine, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Brian
authors.initials: B
authors.lastname: Bolwell
authors.affiliation: John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey; Department of Medicine, Georgetown University School of Medicine, Washington, District of Columbia.
authors.forename: Scott D
authors.initials: SD
authors.lastname: Rowley
authors.affiliation: Mayo Clinic, Rochester, New York.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Litzow
authors.affiliation: Division of Hematology, Oncology, and BMT, Children's Hospital Los Angeles, Los Angeles, California.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Pulsipher
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D006412:Hematopoietic Stem Cells; D006801:Humans; D008603:Mental Health; D008875:Middle Aged; D000072916:Peripheral Blood Stem Cells; D011788:Quality of Life; D035781:Siblings; D014019:Tissue Donors; D055815:Young Adult
keywords: HSC donor health-related quality of life (HRQoL); Hematopoietic stem cell (HSC) donation; Related donation