title: On the shoulders of Hubrecht: From embryos to stem cells.
abstract: One hundred years of the Hubrecht Institute were celebrated in May 2016 with the organization of a one-day symposium "From embryos to stem cells" on the Uithof Campus, Utrecht, the Netherlands. Nine distinguished speakers were invited. They all represent a research branch originating from the passion of Institute founder, Ambrosius Hubrecht, for embryology:, regulation of gene expression, genome structure and function, embryonic and adult stem cells, nuclear reprogramming, and understanding cancer and other diseases using model organisms. The centennial symposium not only retraced the history of the Institute and of modern developmental biology, but was also a tribute to basic research. From there, avenues to therapeutics are being developed and implemented. The symposium was organized, introduced and chaired by Jeroen den Hertog and Alexander van Oudenaarden, the present Directors of the Institute, who also stand on Hubrecht's shoulders.
authors.affiliation: Hubrecht Institute - Koninklijke Nederlandse Akademie van Wetenschappen (KNAW) and University Medical Center Utrecht, Upsalalaan 8, 3584 CT Utrecht, The Netherlands. Electronic address: c.rabouille@hubrecht.eu.
authors.forename: Catherine
authors.initials: C
authors.lastname: Rabouille
authors.affiliation: Hubrecht Institute - Koninklijke Nederlandse Akademie van Wetenschappen (KNAW) and University Medical Center Utrecht, Upsalalaan 8, 3584 CT Utrecht, The Netherlands. Electronic address: j.deschamps@hubrecht.eu.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Deschamps
mesh_terms: D000047:Academies and Institutes / Q000266:history; D000818:Animals; D015509:Developmental Biology / Q000266:history; D004626:Embryology / Q000266:history; D047108:Embryonic Development / Q000235:genetics; D023281:Genomics / Q000266:history; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008495:Medical Oncology / Q000266:history; D009426:Netherlands; D044968:Regenerative Medicine / Q000266:history; D057905:Stem Cell Research / Q000266:history; D013234:Stem Cells
keywords: Adult stem cells; Axial elongation; DNA damage; Developmental Biology; Hox genes; Hubrecht Institute; Human embryonic stem cells; Lgr5; Liver; Nuclear reprogramming; Organoids; PIWI; Protein phosphatase inhibitors; Stomach; Wnt; piRNA