title: Skin steroidogenesis in health and disease.
abstract: The skin is an important extra-gonadal steroidogenic organ, capable of metabolizing various hormones from their precursors, as well as of synthesizing de novo a broad palette of sex steroids and glucocorticoids from cholesterol. In this manuscript, we review the major steroidogenic properties of human skin and we suggest steroidogenesis' impairment as a cardinal factor for various pathological conditions such as acne, rosacea, atopic dermatitis, and androgenic alopecia.
authors.affiliation: Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Auenweg 38, 06847, Dessau, Germany. georgios.nikolakis@klinikum-dessau.de.
authors.forename: Georgios
authors.initials: G
authors.lastname: Nikolakis
authors.affiliation: Section on Endocrinology and Genetics, NICHD, NIH, Bethesda, MD, USA.
authors.forename: Constantine A
authors.initials: CA
authors.lastname: Stratakis
authors.affiliation: Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Auenweg 38, 06847, Dessau, Germany.
authors.forename: Theodora
authors.initials: T
authors.lastname: Kanaki
authors.affiliation: Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA.
authors.forename: Andrej
authors.initials: A
authors.lastname: Slominski
authors.affiliation: Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Auenweg 38, 06847, Dessau, Germany.
authors.forename: Christos C
authors.initials: CC
authors.lastname: Zouboulis
mesh_terms: D006801:Humans; D009747:Nutritional Physiological Phenomena; D012871:Skin Diseases / Q000178:diet therapy / Q000378:metabolism / Q000517:prevention & control; D012879:Skin Physiological Phenomena; D013256:Steroids / Q000378:metabolism*
chemical_list: D013256:Steroids
keywords: 5a-reductase; Acne; Androgen receptor; Androgens; Aromatase; DHEA; Dermatoendocrinology; Estrogens; Glucocorticoids; Rosacea; Steroidogenesis; Steroids; Testosterone