title: End-stage renal disease adherence questionnaire: translation and validation to the portuguese language.
abstract: Non-adherence to medical plans is recognized as an important problem in dialysis patients, since it has been associated with increased morbidity and mortality, resulting in disproportionately high costs of care. The success of renal replacement therapy depends on the adherence of patients to the different aspects of the therapeutic strategy, which includes a complex drug regimen involving a wide variety of drugs and doses, several prescribed dialysis sessions with different durations, dietetic recommendations and restriction of fluid intake. In this work, we aimed to translate and validate a previously described self-reported end-stage renal disease questionnaire (ESRD-AQ) to the Portuguese language (PESRD-AQ). After ESRD-AQ translation, a validation was performed by experts and by using a cohort of 185 Portuguese dialysis patients. PESRD-AQ reliability analysis showed strong test-retest stability across all items, with an intra-class correlation of 0.931. The average of the item-level content validity index by experts for the 46 items was 0.98, ranging from 0.94 to 1. Moreover, we found that PESRD-AQ scores indicative of non-adherence were associated with alterations in some biological and biochemical markers of non-adherence, including interdialytic weight gain. In conclusion, our results showed that PESRD-AQ, which presented an acceptable reliability and validity, is a valid tool to be used for adherence evaluation by Portuguese-speaking dialysis patients.
authors.affiliation: a Abel Salazar Biomedical Sciences Institute, University of Porto , Porto , Portugal.|b Faculty of Social Sciences and Health, University of Santa Elena , La Libertad , Ecuador.|c Center for Health Technology and Services Research (CINTESIS), University of Porto , Porto , Portugal.
authors.forename: Verónica
authors.initials: V
authors.lastname: Poveda
authors.affiliation: d Nephrocare Portugal, SA-Nephrocare Maia , Maia , Portugal.
authors.forename: Leonilde
authors.initials: L
authors.lastname: Amado
authors.affiliation: e Clínica De Hemodiálise De Gondomar , Gondomar , Portugal.
authors.forename: Madalena
authors.initials: M
authors.lastname: Filgueiras
authors.affiliation: a Abel Salazar Biomedical Sciences Institute, University of Porto , Porto , Portugal.|c Center for Health Technology and Services Research (CINTESIS), University of Porto , Porto , Portugal.
authors.forename: Laetitia
authors.initials: L
authors.lastname: Teixeira
authors.affiliation: d Nephrocare Portugal, SA-Nephrocare Maia , Maia , Portugal.|e Clínica De Hemodiálise De Gondomar , Gondomar , Portugal.|f Clínica De Hemodiálise De Felgueira , Felgueiras , Portugal.
authors.forename: Vasco
authors.initials: V
authors.lastname: Miranda
authors.affiliation: g Department of Biological Sciences, Faculty of Pharmacy , University of Porto , Porto , Portugal.|h UCIBIO, REQUIMTE, Faculty of Pharmacy, University of Porto , Portugal.
authors.forename: Alice
authors.initials: A
authors.lastname: Santos-Silva
authors.affiliation: a Abel Salazar Biomedical Sciences Institute, University of Porto , Porto , Portugal.|c Center for Health Technology and Services Research (CINTESIS), University of Porto , Porto , Portugal.
authors.forename: Constança
authors.initials: C
authors.lastname: Paúl
authors.affiliation: g Department of Biological Sciences, Faculty of Pharmacy , University of Porto , Porto , Portugal.|h UCIBIO, REQUIMTE, Faculty of Pharmacy, University of Porto , Portugal.
authors.forename: Elísio
authors.initials: E
authors.lastname: Costa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D007802:Language; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D011174:Portugal; D006435:Renal Dialysis; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires / Q000592:standards*; D014175:Translating
keywords: Adherence; compliance; dialysis; non-adherence; questionnaire