title: Exercise Lowers Plasma Angiopoietin-Like 2 in Men with Post-Acute Coronary Syndrome.
abstract: Pro-inflammatory angiopoietin-like 2 (angptl2) promotes endothelial dysfunction in mice and circulating angptl2 is higher in patients with cardiovascular diseases. We previously reported that a single bout of physical exercise was able to reduce angptl2 levels in coronary patients. We hypothesized that chronic exercise would reduce angptl2 in patients with post-acute coronary syndrome (ACS) and endothelial dysfunction. Post-ACS patients (n = 40, 10 women) were enrolled in a 3-month exercise-based prevention program. Plasma angptl2, hs-CRP, and endothelial function assessed by scintigraphic forearm blood flow, were measured before and at the end of the study. Exercise increased VO2peak by 10% (p<0.05), but did not significantly affect endothelial function, in both men and women. In contrast, exercise reduced angptl2 levels only in men (-26±7%, p<0.05), but unexpectedly not in women (+30±16%), despite similar initial levels in both groups. Exercise reduced hs-CRP levels in men but not in women. In men, levels of angptl2, but not of hs-CRP, reached at the end of the training program were negatively correlated with VO2peak (r = -0.462, p = 0.012) and with endothelial function (r = -0.419, p = 0.033) measured at baseline: better initial cardiopulmonary fitness and endothelial function correlated with lower angptl2 levels after exercise. Pre-exercise angptl2 levels were lower if left ventricular ejection time was long (p<0.05) and the drop in angptl2 induced by exercise was greater if the cardiac output was high (p<0.05). In conclusion, in post-ACS men, angptl2 levels are sensitive to chronic exercise training. Low circulating angptl2 reached after training may reflect good endothelial and cardiopulmonary functions.
authors.affiliation: Montreal Heart Institute, Research Center, University of Montreal, Montreal, Quebec, Canada.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Thorin-Trescases
authors.affiliation: Montreal Heart Institute, Research Center, University of Montreal, Montreal, Quebec, Canada.|Cardiac Rehabilitation and Prevention Center (EPIC) of the Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada.
authors.forename: Doug
authors.initials: D
authors.lastname: Hayami
authors.affiliation: Montreal Heart Institute, Research Center, University of Montreal, Montreal, Quebec, Canada.|Departments of Pharmacology and Surgery, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada.
authors.forename: Carol
authors.initials: C
authors.lastname: Yu
authors.affiliation: Montreal Heart Institute, Research Center, University of Montreal, Montreal, Quebec, Canada.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Luo
authors.affiliation: Montreal Heart Institute, Research Center, University of Montreal, Montreal, Quebec, Canada.|Departments of Pharmacology and Surgery, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada.
authors.forename: Albert
authors.initials: A
authors.lastname: Nguyen
authors.affiliation: Montreal Heart Institute, Research Center, University of Montreal, Montreal, Quebec, Canada.|Cardiac Rehabilitation and Prevention Center (EPIC) of the Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Larouche
authors.affiliation: Cardiac Rehabilitation and Prevention Center (EPIC) of the Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada.
authors.forename: Julie
authors.initials: J
authors.lastname: Lalongé
authors.affiliation: Montreal Heart Institute, Research Center, University of Montreal, Montreal, Quebec, Canada.
authors.forename: Christine
authors.initials: C
authors.lastname: Henri
authors.affiliation: Montreal Heart Institute, Research Center, University of Montreal, Montreal, Quebec, Canada.|Montreal Behavioral Medicine Centre, Montreal, Quebec, Canada.
authors.forename: André
authors.initials: A
authors.lastname: Arsenault
authors.affiliation: Montreal Heart Institute, Research Center, University of Montreal, Montreal, Quebec, Canada.|Cardiac Rehabilitation and Prevention Center (EPIC) of the Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Gayda
authors.affiliation: Montreal Heart Institute, Research Center, University of Montreal, Montreal, Quebec, Canada.|Cardiac Rehabilitation and Prevention Center (EPIC) of the Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada.
authors.forename: Martin
authors.initials: M
authors.lastname: Juneau
authors.affiliation: Montreal Heart Institute, Research Center, University of Montreal, Montreal, Quebec, Canada.|School of Public Health, University of Montreal, Montreal, Quebec, Canada.
authors.forename: Jean
authors.initials: J
authors.lastname: Lambert
authors.affiliation: Montreal Heart Institute, Research Center, University of Montreal, Montreal, Quebec, Canada.|Departments of Pharmacology and Surgery, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada.
authors.forename: Eric
authors.identifier: http://orcid.org/0000-0001-5827-8935
authors.initials: E
authors.lastname: Thorin
authors.affiliation: Montreal Heart Institute, Research Center, University of Montreal, Montreal, Quebec, Canada.|Cardiac Rehabilitation and Prevention Center (EPIC) of the Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada.
authors.forename: Anil
authors.initials: A
authors.lastname: Nigam
mesh_terms: D054058:Acute Coronary Syndrome / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000503:physiopathology; D000091302:Angiopoietin-Like Protein 2; D000075802:Angiopoietin-like Proteins; D042682:Angiopoietins / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism*; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test / Q000379:methods; D005260:Female; D005542:Forearm / Q000098:blood supply / Q000000981:diagnostic imaging; D015637:Gated Blood-Pool Imaging; D006801:Humans; D008297:Male
chemical_list: C485792:ANGPTL2 protein, human; D000091302:Angiopoietin-Like Protein 2; D000075802:Angiopoietin-like Proteins; D042682:Angiopoietins; D002097:C-Reactive Protein