title: Near-Infrared Organic Dye-Based Nanoagent for the Photothermal Therapy of Cancer.
abstract: Given their easy structural modification and good biocompatibility advantages, near-infrared (NIR) organic dyes with a large molar extinction coefficient, while a superlow fluorescence quantum yield shows considerable potential application in photothermal therapy (PTT). Herein, a new NIR-absorbing asymmetric cyanine dye, namely, RC, is designed and synthesized via the hybrid of rhodamine and hemicyanine derivatives. RC-BSA nanoparticles (NPs) are fabricated by using the bovine serum albumin (BSA) matrix. The NPs exhibit a strong NIR absorption peak at ∼868 nm and 28.7% photothermal conversion efficiency. Based on these features, RC-BSA NPs exhibit excellent performance in ablating tumor under a 915 nm laser radiation through a PTT mechanism. These NPs show no obvious toxicity to the treated mice. Thus, RC-BSA NPs can used as a new NIR laser-triggered PTT agent in cancer treatment.
authors.affiliation: Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University , Beijing 100084, China.
authors.forename: Bingjiang
authors.initials: B
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University , Beijing 100084, China.
authors.forename: Yunzheng
authors.initials: Y
authors.lastname: Li
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials and City U-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
authors.forename: Guangle
authors.initials: G
authors.lastname: Niu
authors.affiliation: Center Of Super-Diamond and Advanced Films and Department of Physics and Materials Science, City University of Hong Kong , Hong Kong SAR, China.
authors.forename: Minhuan
authors.initials: M
authors.lastname: Lan
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials and City U-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
authors.forename: Qingyan
authors.initials: Q
authors.lastname: Jia
authors.affiliation: Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University , Beijing 100084, China.
authors.forename: Qionglin
authors.initials: Q
authors.lastname: Liang
mesh_terms: D000818:Animals; D004396:Coloring Agents / Q000737:chemistry*; D051379:Mice; D053758:Nanoparticles; D009369:Neoplasms; D010789:Phototherapy; D012710:Serum Albumin, Bovine
chemical_list: D004396:Coloring Agents; D012710:Serum Albumin, Bovine
keywords: cancer; nanoparticle; near-infrared; organic dye; photothermal therapy