title: Crosstalk between autophagy and intracellular radiation response (Review).
abstract: Autophagy induced by radiation is critical to cell fate decision. Evidence now sheds light on the importance of autophagy induced by cancer radiotherapy. Traditional view considers radiation can directly or indirectly damage DNA which can activate DNA damage the repair signaling pathway, a large number of proteins participating in DNA damage repair signaling pathway such as p53, ATM, PARP1, FOXO3a, mTOR and SIRT1 involved in autophagy regulation. However, emerging recent evidence suggests radiation can also cause injury to extranuclear targets such as plasma membrane, mitochondria and endoplasmic reticulum (ER) and induce accumulation of ceramide, ROS, and Ca2+ concentration which activate many signaling pathways to modulate autophagy. Herein we review the role of autophagy in radiation therapy and the potent intracellular autophagic triggers induced by radiation. We aim to provide a more theoretical basis of radiation-induced autophagy, and provide novel targets for developing cytotoxic drugs to increase radiosensitivity.
authors.affiliation: Department of Radiation Oncology, Peking University Third Hospital, Haidian, Beijing 100191, P.R. China.
authors.forename: Lelin
authors.initials: L
authors.lastname: Hu
authors.affiliation: Department of Radiation Oncology, Peking University Third Hospital, Haidian, Beijing 100191, P.R. China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Radiation Oncology, Peking University Third Hospital, Haidian, Beijing 100191, P.R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Huang
authors.affiliation: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P.R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Radiation Oncology, Peking University Third Hospital, Haidian, Beijing 100191, P.R. China.
authors.forename: Junjie
authors.initials: J
authors.lastname: Wang
mesh_terms: D001343:Autophagy / Q000528:radiation effects*; D004249:DNA Damage / Q000235:genetics / Q000528:radiation effects; D004260:DNA Repair / Q000235:genetics / Q000528:radiation effects; D004721:Endoplasmic Reticulum / Q000473:pathology / Q000528:radiation effects*; D059865:Endoplasmic Reticulum Stress / Q000528:radiation effects*; D006801:Humans; D008928:Mitochondria / Q000473:pathology / Q000528:radiation effects*; D009369:Neoplasms / Q000235:genetics / Q000532:radiotherapy*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species