title: Anorexia of aging and its role for frailty.
abstract: The purpose of this review is to examine the concept of anorexia of aging, including its complex pathophysiology and the multifaceted interventions required to prevent adverse health consequences from this geriatric syndrome.
  
  
  
  Anorexia of aging is extremely common, occurring in up to 30% of elderly individuals; however, this diagnosis is frequently missed or erroneously attributed to a normal part of the aging process. With aging, impairments in smell and taste can limit the desire to eat. Alterations in stress hormones and inflammatory mediators can lead to excess catabolism, cachexia, and reduced appetite. In addition, mood disorders, such as anxiety and depression, are powerful inhibitors of appetite. Anorexia of aging, with its negative consequences on weight and muscle mass, is a risk factor for the development of frailty and is important to screen for, as early intervention is key to reversing this debilitating condition.
  
  
  
  Anorexia of aging is a complex geriatric syndrome and a direct risk factor for frailty and thus should not be accepted as normal consequence of aging. Early diagnosis and formulating a plan for targeted interventions is critical to prevent disability and preserve function in elderly patients.
authors.affiliation: Division of Geriatric Medicine, Saint Louis University School of Medicine, St. Louis, Missouri, USA.
authors.forename: Angela M
authors.initials: AM
authors.lastname: Sanford
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology* / Q000523:psychology; D000855:Anorexia / Q000150:complications / Q000503:physiopathology* / Q000523:psychology; D001066:Appetite / Q000502:physiology; D002100:Cachexia / Q000209:etiology / Q000503:physiopathology; D003863:Depression / Q000150:complications / Q000503:physiopathology; D005260:Female; D000073496:Frailty / Q000209:etiology*; D006801:Humans; D008297:Male