title: [The clinical analysis of 18 cases with bilateral lung transplantation for severe idiopathic pulmonary arterial hypertension].
abstract: Objective:To study the clinical efficacy of bilateral lung transplantation treating for severe idiopathic pulmonary hypertension (IPAH).Methods:The clinical data of 18 cases of bilateral lung transplantation for severe IPAH were retrospectively analyzed. Comparative analysis of preoperative and postoperative sets of data was performed.Results:The postoperative 30-day mortality of 18 cases was 11.1%, 3 months mortality 22.2%. The survival rate of 1 year, 3 years, 5 years was 77.8%, 72.2% and 72.2%, respectively. The remaining 13 cases were able to survive for a long time which preoperative cardiac function rating of level Ⅲ, Ⅳ were improved to level Ⅰafter transplantation. Compared preoperative with postoperative, pulmonary artery systolic pressure from preoperative 128.2±25.6 mmHg dropped to postoperative 39.7±14.8 mmHg; pulmonary artery mean pressure from 75.5±13.94 mmHg to 19.61±6.43 mmHg; right atrial pressure from 21.5±2.43 mmHg to 5.22±4.18 mmHg, allP<0.000 1.Conclusion:Bilateral lung transplantation is an effective treatment for severe idiopathic pulmonary arterial hypertension, which has longer survival.
authors.affiliation: Center of Lung Transplantation, Wuxi People's Hospital, Affiliated Hospital of Nanjing Medical University, Wuxi 214023, China.
authors.forename: S J
authors.initials: SJ
authors.lastname: Zhu
authors.affiliation: Center of Lung Transplantation, Wuxi People's Hospital, Affiliated Hospital of Nanjing Medical University, Wuxi 214023, China.
authors.forename: J Y
authors.initials: JY
authors.lastname: Chen
authors.affiliation: Center of Lung Transplantation, Wuxi People's Hospital, Affiliated Hospital of Nanjing Medical University, Wuxi 214023, China.
authors.forename: B
authors.initials: B
authors.lastname: Wu
authors.affiliation: Center of Lung Transplantation, Wuxi People's Hospital, Affiliated Hospital of Nanjing Medical University, Wuxi 214023, China.
authors.forename: M
authors.initials: M
authors.lastname: Zhou
authors.affiliation: Center of Lung Transplantation, Wuxi People's Hospital, Affiliated Hospital of Nanjing Medical University, Wuxi 214023, China.
authors.forename: D
authors.initials: D
authors.lastname: Wei
authors.affiliation: Center of Lung Transplantation, Wuxi People's Hospital, Affiliated Hospital of Nanjing Medical University, Wuxi 214023, China.
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Center of Lung Transplantation, Wuxi People's Hospital, Affiliated Hospital of Nanjing Medical University, Wuxi 214023, China.
authors.forename: H
authors.initials: H
authors.lastname: Yang
authors.affiliation: Center of Lung Transplantation, Wuxi People's Hospital, Affiliated Hospital of Nanjing Medical University, Wuxi 214023, China.
authors.forename: L
authors.initials: L
authors.lastname: Fan
mesh_terms: D065627:Familial Primary Pulmonary Hypertension; D006801:Humans; D016040:Lung Transplantation; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome