title: Outcome and current status of therapeutic hypothermia after out-of-hospital cardiac arrest in Korea using data from the Korea Hypothermia Network registry.
abstract: OBJECTIVE
  Therapeutic hypothermia (TH) has become the standard strategy for reducing brain damage in the postresuscitation period. The aim of this study was to investigate current TH performance and outcomes in out-of-hospital cardiac arrest (OHCA) survivors using data from the Korean Hypothermia Network (KORHN) registry.
  
  
  METHODS
  We used the KORHN registry, a web-based multicenter registry that includes 24 participating hospitals throughout the Republic of Korea. Adult comatose OHCA survivors treated with TH between 2007 and 2012 were included. The primary outcomes were neurological outcome at hospital discharge and in-hospital mortality. The secondary outcomes were TH performance and adverse events during TH.
  
  
  RESULTS
  A total of 930 patients were included, of whom 556 (59.8%) survived to discharge and 249 (26.8%) were discharged with good neurologic outcomes. The median time from return of spontaneous circulation (ROSC) to the start of TH was 101 minutes (interquartile range [IQR], 46 to 200 minutes). The induction, maintenance, and rewarming durations were 150 minutes (IQR, 80 to 267 minutes), 1,440 minutes (IQR, 1,290 to 1,440 minutes), and 708 minutes (IQR, 420 to 900 minutes), respectively. The time from the ROSC to coronary angiography was 1,045 hours (IQR, 121 to 12,051 hours). Hyperglycemia (46.3%) was the most frequent adverse event.
  
  
  CONCLUSIONS
  More than one-quarter of the OHCA survivors (26.8%) were discharged with good neurologic outcomes. TH performance was appropriately managed in terms of the factors related to its timing, including cooling start time and rewarming duration.
authors.affiliation: Department of Emergency Medicine, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Byung Kook
authors.initials: BK
authors.lastname: Lee
authors.affiliation: Department of Emergency Medicine, The Catholic University of Korea School of Medicine, Seoul, Korea.
authors.forename: Kyu Nam
authors.initials: KN
authors.lastname: Park
authors.affiliation: Department of Emergency Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea.
authors.forename: Gu Hyun
authors.initials: GH
authors.lastname: Kang
authors.affiliation: Department of Emergency Medicine, Inje University Ilsan Paik Hospital, Goyang, Korea.
authors.forename: Kyung Hwan
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Department of Emergency Medicine, Ajou University Hospital, Suwon, Korea.
authors.forename: Giwoon
authors.initials: G
authors.lastname: Kim
authors.affiliation: Department of Emergency Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Won Young
authors.initials: WY
authors.lastname: Kim
authors.affiliation: Department of Emergency Medicine, Chungbuk National University College of Medicine, Cheongju, Korea.
authors.forename: Jin Hong
authors.initials: JH
authors.lastname: Min
authors.affiliation: Department of Emergency Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Yooseok
authors.initials: Y
authors.lastname: Park
authors.affiliation: Department of Emergency Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Jung Bae
authors.initials: JB
authors.lastname: Park
authors.affiliation: Department of Emergency Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Gil Joon
authors.initials: GJ
authors.lastname: Suh
authors.affiliation: Department of Emergency Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea.
authors.forename: Yoo Dong
authors.initials: YD
authors.lastname: Son
authors.affiliation: Department of Emergency Medicine, Seoul National University Boramae Medical Center, Seoul, Korea.
authors.forename: Jonghwan
authors.initials: J
authors.lastname: Shin
authors.affiliation: Department of Emergency Medicine, The Catholic University of Korea School of Medicine, Seoul, Korea.
authors.forename: Joo Suk
authors.initials: JS
authors.lastname: Oh
authors.affiliation: Department of Emergency Medicine, Chungnam National University School of Medicine, Daejeon, Korea.
authors.forename: Yeon Ho
authors.initials: YH
authors.lastname: You
authors.affiliation: Department of Emergency Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Dong Hoon
authors.initials: DH
authors.lastname: Lee
authors.affiliation: Department of Emergency Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Jong Seok
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Department of Emergency Medicine, Soonchunhyang University College of Medicine, Bucheon, Korea.
authors.forename: Hoon
authors.initials: H
authors.lastname: Lim
authors.affiliation: Department of Emergency Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea.
authors.forename: Tae Chang
authors.initials: TC
authors.lastname: Jang
authors.affiliation: Department of Emergency Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea.
authors.forename: Gyu Chong
authors.initials: GC
authors.lastname: Cho
authors.affiliation: Department of Emergency Medicine, Hanil General Hospital, Korea Electric Power Medical Corporation, Seoul, Korea.
authors.forename: In Soo
authors.initials: IS
authors.lastname: Cho
authors.affiliation: Department of Emergency Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
authors.forename: Kyoung Chul
authors.initials: KC
authors.lastname: Cha
authors.affiliation: Department of Emergency Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
authors.forename: Seung Pill
authors.initials: SP
authors.lastname: Choi
authors.affiliation: Department of Emergency Medicine, Ulsan University College of Medicine, Ulsan, Korea.
authors.forename: Wook Jin
authors.initials: WJ
authors.lastname: Choi
authors.affiliation: Department of Emergency Medicine, Ewha Womans School of Medicine, Seoul, Korea.
authors.forename: Chul
authors.initials: C
authors.lastname: Han
keywords: Hypothermia, induced; Out-of-hospital cardiac arrest; Registries