title: The significance of Hsp70 subnetwork for Dengue virus lifecycle.
abstract: Viruses hijack host machineries for replicating themselves efficiently. Host protein quality control machineries (QC) not only assist protein folding to form bona fide proteins with active functions but also get rid of un/misfolded proteins via degradation to maintain the protein homeostasis. Previous studies have reported that viruses utilize QC at various steps for their lifecycles. Recently we defined Hsp70s and their cochaperones, DnaJs functions on Dengue lifecycle. Here we summarize the significance of QC on Dengue virus.
authors.affiliation: Department of Biology and Bio-X, Stanford University.
authors.forename: Shuhei
authors.initials: S
authors.lastname: Taguwa
authors.forename: Judithi
authors.initials: J
authors.lastname: Frydman
mesh_terms: D000818:Animals; D003716:Dengue Virus / Q000254:growth & development* / Q000378:metabolism* / Q000502:physiology*; D050956:HSP40 Heat-Shock Proteins / Q000378:metabolism / Q000502:physiology; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism* / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D008018:Life Cycle Stages / Q000235:genetics* / Q000502:physiology*; D051379:Mice; D018832:Molecular Chaperones; D017510:Protein Folding; D046188:Protein Modification, Translational; D014779:Virus Replication / Q000235:genetics* / Q000502:physiology*
chemical_list: D050956:HSP40 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; D018832:Molecular Chaperones