title: Synthesis and anti-inflammatory evaluation of novel paclitaxel analogs.
abstract: A series of paclitaxel analogs modified at C-3'-N and C-7 positions were synthesized from baccatin III and their structures were confirmed by1H-NMR,13C-NMR, HR-MS. Compound 7e exhibited potent ability to decrease TNFα (tumor necrosis factor α) in the LPS-activated RAW264.7 murine macrophage-like cell line. The preliminary data indicated that the anti-inflammatory effects may be related to MD-2 and Toll-like receptor 4 (TLR4), rather than Toll-like receptor 2 (TLR2).
authors.affiliation: a Department of Chemistry , Innovative Drug Research Center, College of Sciences, Shanghai University , Shanghai 200444 , China.
authors.forename: Pei-Pei
authors.initials: PP
authors.lastname: Xu
authors.affiliation: a Department of Chemistry , Innovative Drug Research Center, College of Sciences, Shanghai University , Shanghai 200444 , China.
authors.forename: Qing-Feng
authors.initials: QF
authors.lastname: Li
authors.affiliation: a Department of Chemistry , Innovative Drug Research Center, College of Sciences, Shanghai University , Shanghai 200444 , China.
authors.forename: Yong-Mei
authors.initials: YM
authors.lastname: Cui
authors.affiliation: a Department of Chemistry , Innovative Drug Research Center, College of Sciences, Shanghai University , Shanghai 200444 , China.
authors.forename: Hai-Xia
authors.initials: HX
authors.lastname: Lin
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020650:Combinatorial Chemistry Techniques; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D017239:Paclitaxel / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015398:Signal Transduction; D043823:Taxoids / Q000737:chemistry*; D051195:Toll-Like Receptor 2 / Q000187:drug effects; D051197:Toll-Like Receptor 4 / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000187:drug effects
chemical_list: D000470:Alkaloids; D000893:Anti-Inflammatory Agents; D008070:Lipopolysaccharides; D043823:Taxoids; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4; D014409:Tumor Necrosis Factor-alpha; C073950:baccatin III; D017239:Paclitaxel
keywords: Paclitaxel; anti-inflammatory; lipopolysaccharide; tumor necrosis factor α