title: Quantitative and regiocontrolled cross-photocycloaddition of the anticancer drug 5-fluorouracil achieved in a cocrystal.
abstract: We describe a [2+2] cross-photocycloaddition of the anticancer drug 5-fluorouracil in the solid state that proceeds regioselectively and in quantitative yield. The photocycloaddition occurs in a cocrystal with trans-2,2'-bis(pyridyl)ethylene.
authors.affiliation: Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, USA. len-macgillivray@uiowa.edu.
authors.forename: Andrew J E
authors.initials: AJ
authors.lastname: Duncan
authors.forename: Roxanne L
authors.initials: RL
authors.lastname: Dudovitz
authors.forename: Shawna J
authors.initials: SJ
authors.lastname: Dudovitz
authors.forename: Jelena
authors.initials: J
authors.lastname: Stojaković
authors.forename: S V Santhana
authors.initials: SV
authors.lastname: Mariappan
authors.forename: Leonard R
authors.initials: LR
authors.lastname: MacGillivray
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D003460:Crystallization; D061565:Cycloaddition Reaction; D005472:Fluorouracil / Q000138:chemical synthesis* / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D055668:Photochemical Processes; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D005472:Fluorouracil