title: Acquired Factor V Inhibitor.
abstract: Inhibitors directed against factor V rarely occur, and the clinical symptoms vary. We herein report the case of a patient who presented with a decreased factor V activity that had decreased to <3 %. We administered vitamin K and 6 units of fresh frozen plasma, but she thereafter developed an intracerebral hemorrhage. It is unclear whether surgery >10 years earlier might have caused the development of a factor V inhibitor. The treatment of acquired factor V inhibitors is mainly the transfusion of platelet concentrates and corticosteroids. Both early detection and the early initiation of the treatment of factor V inhibitor are thus considered to be important.
authors.affiliation: Departmant of General Medicine, National Hospital Organization Kyoto Medical Center, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Hirai
authors.forename: Yugo
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Nobutoyo
authors.initials: N
authors.lastname: Masunaga
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Katsura
authors.forename: Masaharu
authors.initials: M
authors.lastname: Akao
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Okuno
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Koyama
mesh_terms: D000368:Aged; D002543:Cerebral Hemorrhage / Q000209:etiology*; D005165:Factor V / Q000037:antagonists & inhibitors*; D005166:Factor V Deficiency / Q000209:etiology* / Q000628:therapy*; D005260:Female; D006801:Humans; D010949:Plasma; D017713:Platelet Transfusion
chemical_list: D005165:Factor V