title: Vitamin D Level Between Calcium-Phosphorus Homeostasis and Immune System: New Perspective in Osteoporosis.
abstract: Vitamin D is a key molecule in calcium and phosphate homeostasis; however, increasing evidence has recently shown that it also plays a crucial role in the immune system, both innate and adaptive. A deregulation of vitamin D levels, due also to mutations and polymorphisms in the genes of the vitamin D pathway, determines severe alterations in the homeostasis of the organism, resulting in a higher risk of onset of some diseases, including osteoporosis. This review gives an overview of the influence of vitamin D levels on the pathogenesis of osteoporosis, between bone homeostasis and immune system.
authors.affiliation: Innovative Technology Platforms for Tissue Engineering, Theranostics and Oncology, Rizzoli Orthopaedic Institute, Via Divisi, 83, 90100, Palermo, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Bellavia
authors.affiliation: Innovative Technology Platforms for Tissue Engineering, Theranostics and Oncology, Rizzoli Orthopaedic Institute, Via Divisi, 83, 90100, Palermo, Italy.
authors.forename: Viviana
authors.initials: V
authors.lastname: Costa
authors.affiliation: Innovative Technology Platforms for Tissue Engineering, Theranostics and Oncology, Rizzoli Orthopaedic Institute, Via Divisi, 83, 90100, Palermo, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: De Luca
authors.affiliation: Laboratory of Biocompatibility, Technological Innovations and Advanced Therapies, Rizzoli Orthopaedic Institute, Bologna, Italy.
authors.forename: Melania
authors.initials: M
authors.lastname: Maglio
authors.affiliation: Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopaedic Institute, Bologna, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Pagani
authors.affiliation: Laboratory of Biocompatibility, Technological Innovations and Advanced Therapies, Rizzoli Orthopaedic Institute, Bologna, Italy.
authors.forename: Milena
authors.initials: M
authors.lastname: Fini
authors.affiliation: Innovative Technology Platforms for Tissue Engineering, Theranostics and Oncology, Rizzoli Orthopaedic Institute, Via Divisi, 83, 90100, Palermo, Italy. daniele.bellavia@ior.it.
authors.forename: Gianluca
authors.identifier: 0000-0001-7843-5969
authors.initials: G
authors.lastname: Giavaresi
mesh_terms: D006801:Humans; D014807:Vitamin D / Q000378:metabolism; D006706:Homeostasis; D010024:Osteoporosis / Q000276:immunology / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism; D007107:Immune System
chemical_list: D014807:Vitamin D; D002118:Calcium; D010758:Phosphorus
keywords: Calcium-phosphorus homeostasis; Immune system; Osteoporosis; Polymorphisms; Vitamin D