title: Acting on Actin: Rac and Rho Played by Yersinia.
abstract: Pathogenic bacteria of the genus Yersinia include Y. pestis-the agent of plaque-and two enteropathogens, Y. enterocolitica, and Y. pseudotuberculosis. These pathogens have developed an array of virulence factors aimed at manipulating Rho GTP-binding proteins and the actin cytoskeleton in host cells to cross the intestinal barrier and suppress the immune system. Yersinia virulence factors include outer membrane proteins triggering cell invasion by binding to integrins, effector proteins injected into host cells to manipulate Rho protein functions and a Rho protein-activating exotoxin. Here, we present an overview of how Yersinia and host factors are integrated in a regulatory network that orchestrates the subversion of host defense.
authors.affiliation: Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. m.aepfelbacher@uke.de.
authors.forename: Martin
authors.initials: M
authors.lastname: Aepfelbacher
authors.affiliation: Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
authors.forename: Manuel
authors.initials: M
authors.lastname: Wolters
mesh_terms: D000199:Actins / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D054884:Host-Pathogen Interactions; D006801:Humans; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D015007:Yersinia / Q000235:genetics / Q000378:metabolism*; D015009:Yersinia Infections / Q000201:enzymology* / Q000378:metabolism / Q000382:microbiology; D054460:rho-Associated Kinases / Q000235:genetics / Q000378:metabolism*
chemical_list: D000199:Actins; D001426:Bacterial Proteins; D051057:Proto-Oncogene Proteins c-akt; D054460:rho-Associated Kinases