title: Expression of TREM-1 in maternal leukocytes in preterm, prelabour rupture of the membranes.
abstract: Studies have shown that triggering receptor expressed on myeloid cells-1 (TREM-1) is the mediator and activator of neutrophils and monocytes after stimulation with lipopolysaccharide (LPS), heat-inactivated Gram (-) bacteria, Gram (+) bacteria or fungi. Different studies have measured the expression of TREM-1 in patients with bacterial infections and critical states. The purpose of this study was to evaluate the expression of TREM-1 in circulating maternal leukocytes in premature rupture of the membranes (PRM). Two groups of patients were included in this case control study: pregnant women with PRM and healthy controls. All patients were free of any infection, including cervix and urinary tract. Although all patients expressed TREM-1 to some extent, there was no statistically significant difference in the expression of different cellularities in both groups; except for the mononuclear leukocytes (p < 0.05). In this study, TREM-1 was not altered in PRM.
authors.affiliation: a The Direction of Research and Education , The Hospital of Obstetrics and Ginecology , Guadalajara , Jalisco , México.|b Division of Research , The Autonomous University of Guadalajara , Guadalajara , Jalisco , México.
authors.forename: Roberto
authors.initials: R
authors.lastname: Anaya-Prado
authors.affiliation: a The Direction of Research and Education , The Hospital of Obstetrics and Ginecology , Guadalajara , Jalisco , México.
authors.forename: Manuel Fernando
authors.initials: MF
authors.lastname: Barba-Anaya
authors.affiliation: b Division of Research , The Autonomous University of Guadalajara , Guadalajara , Jalisco , México.
authors.forename: Jorge Manuel
authors.initials: JM
authors.lastname: Sánchez-González
authors.affiliation: a The Direction of Research and Education , The Hospital of Obstetrics and Ginecology , Guadalajara , Jalisco , México.|b Division of Research , The Autonomous University of Guadalajara , Guadalajara , Jalisco , México.
authors.forename: Michelle Marie
authors.initials: MM
authors.lastname: Anaya-Fernández
authors.affiliation: a The Direction of Research and Education , The Hospital of Obstetrics and Ginecology , Guadalajara , Jalisco , México.
authors.forename: Ana Bertha
authors.initials: AB
authors.lastname: Zavalza-Gómez
authors.affiliation: a The Direction of Research and Education , The Hospital of Obstetrics and Ginecology , Guadalajara , Jalisco , México.
authors.forename: Francisco
authors.initials: F
authors.lastname: Gil-Villarreal
authors.affiliation: c The Centro de Investigation Biomedical de Occidente , The Western Medical Centre, The Mexican Institute for Social Security , Guadalajara , Jalisco , México.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Bravo-Cuellar
authors.affiliation: a The Direction of Research and Education , The Hospital of Obstetrics and Ginecology , Guadalajara , Jalisco , México.|b Division of Research , The Autonomous University of Guadalajara , Guadalajara , Jalisco , México.
authors.forename: Andrea Del Carmen
authors.initials: AD
authors.lastname: Grijalva-Solis
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000209:etiology / Q000378:metabolism; D005434:Flow Cytometry; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000276:immunology / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000097:blood / Q000276:immunology / Q000378:metabolism*; D009504:Neutrophils / Q000276:immunology / Q000378:metabolism*; D011247:Pregnancy; D011971:Receptors, Immunologic / Q000097:blood / Q000276:immunology / Q000378:metabolism*; D018709:Statistics, Nonparametric; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; D055815:Young Adult
chemical_list: D015415:Biomarkers; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
keywords: TREM-1; pregnancy; premature rupture of membranes