title: [Clinicopathologic Features and Prognostic Implications in 72 Cases  with Lung Adenosquamous Carcinoma].
abstract: BACKGROUND
  Adenosquamous carcinoma (ASC) is a rare subtype of lung cancer, it is mixed glandular and squamous cell carcinoma with a more aggressive behavior and poor prognosis than the other histologic subtypes. The aim of the study was to explore the clinicopathological characteristics and prognostic factors of ASC.
  
  
  METHODS
  A total of 72 patients were enrolled. We investigated clinicalpathological features and prognostic factors retrospectively.
  
  
  RESULTS
  The overall 72 ASC patients' median age was 34.7 months, 5-year survival rate was 14.9%. The influence of tumor size, M stage, and N stage, gene mutation and surgery on the prognosis of patients show statistical significance.
  
  
  CONCLUSIONS
  ASC is characterized by both histologic aggressiveness and adverse prognosis. We suggest the comprehensive therapy based on surgery, and given small molecule tyrosine kinase inhibitors (TKIs) treatment may prolong patients' overall survival.
authors.affiliation: General Department, National Cancer Center/Cancer Hospital Chinese  Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Wu
authors.affiliation: Internal Department, National Cancer Center/Cancer Hospital Chinese  Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
authors.forename: Junling
authors.initials: J
authors.lastname: Li
authors.affiliation: Medical Record Department, National Cancer Center/Cancer Hospital Chinese  Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
authors.forename: Shulan
authors.initials: S
authors.lastname: Chen
authors.affiliation: General Department, National Cancer Center/Cancer Hospital Chinese  Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yu
authors.affiliation: General Department, National Cancer Center/Cancer Hospital Chinese  Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
authors.forename: Boyan
authors.initials: B
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018196:Carcinoma, Adenosquamous / Q000175:diagnosis / Q000235:genetics / Q000401:mortality* / Q000473:pathology*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000401:mortality* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate