title: Assessment of Factors Related to Adherence to Treatment in Liver Transplantation Candidates.
abstract: BACKGROUND
  The relevance that adherence to treatment plays in liver transplantation, and the impact this factor may have on the success of treatment, are fundamental in assessing the variables which affect patient adherence during the pretransplantation period.
  
  
  OBJECTIVE
  This study aims to determine factors that affect liver transplant candidates' adherence to treatment, and analyze the association between adherence, socioeconomic and demographic factors, clinical characteristics, and patient understanding about the disease and liver transplantation.
  
  
  METHODS
  This epidemiological, observational, and prospective study included 62 patients registered in the technical database of the Universidade Federal de São Paulo during the period November 2012-May 2014. The dependent variable was adherence to treatment among liver transplantation candidates, and the independent variables included understanding the disease and the transplantation process, and depression and anxiety symptoms among liver transplantation candidates.
  
  
  RESULTS
  Work situation (P = .038), understanding about the disease (P = .002), and use of laxatives (P = .045) were the factors related to statistically significant adherence, and it can be concluded that implementation of an educational program may increase adherence up to 3.48 times in the pretransplantation phase, as adherence was 3.48 times lower in patients who reported little or no knowledge of the disease or the procedure.
authors.affiliation: Escola Paulista de Enfermagem, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil. Electronic address: pri.transplante@gmail.com.
authors.forename: P C
authors.initials: PC
authors.lastname: de Oliveira
authors.affiliation: Escola Paulista de Enfermagem, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
authors.forename: S
authors.initials: S
authors.lastname: Mucci
authors.affiliation: Escola Paulista de Enfermagem, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil; Queen's University at Kingston, Kingston, ON, Canada.
authors.forename: V
authors.initials: V
authors.lastname: Silva E Silva
authors.affiliation: Escola Paulista de Enfermagem, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
authors.forename: R F
authors.initials: RF
authors.lastname: Leite
authors.affiliation: Escola Paulista de Enfermagem, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
authors.forename: H B
authors.initials: HB
authors.lastname: Paglione
authors.affiliation: Escola Paulista de Enfermagem, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
authors.forename: J L
authors.initials: JL
authors.lastname: Erbs
authors.affiliation: Service Operations Management Coordinator, Center for Health Care Studies, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
authors.forename: C A S
authors.initials: CA
authors.lastname: Araújo
authors.affiliation: Escola Paulista de Enfermagem, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
authors.forename: J
authors.initials: J
authors.lastname: Schirmer
authors.affiliation: Escola Paulista de Enfermagem, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
authors.forename: B
authors.initials: B
authors.lastname: de Aguiar Roza
mesh_terms: D000328:Adult; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance / Q000706:statistics & numerical data*; D010353:Patient Education as Topic; D011446:Prospective Studies