title: Chordomas and chondrosarcomas-The role of radiation therapy.
abstract: Achieving negative surgical margins can be challenging for skull base and spinal/paraspinal sarcomas. Data shows that pre- or post-operative radiation therapy improves local control. Delivery of sufficient dose of radiation can be difficult because of the proximity to normal organs/tissues that are sensitive to radiation therapy and therefore dose-limiting. A comprehensive literature search was conducted using PubMed search engine. The scarcity of prospective, randomized data limits the ability to generate definitive treatment recommendations. J. Surg. Oncol. 2016;114:564-569. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts. kbernstein@mgh.harvard.edu.
authors.forename: Karen
authors.initials: K
authors.lastname: De Amorim Bernstein
authors.affiliation: Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts.
authors.forename: Thomas
authors.initials: T
authors.lastname: DeLaney
mesh_terms: D002813:Chondrosarcoma / Q000532:radiotherapy* / Q000601:surgery*; D002817:Chordoma / Q000532:radiotherapy* / Q000601:surgery*; D006801:Humans; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D019292:Skull Base Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D013125:Spinal Neoplasms / Q000532:radiotherapy* / Q000601:surgery
keywords: base of skull/spine; proton therapy; rare tumors