title: Biological activities of triterpenoids from Poraqueiba sericea stems.
abstract: Eleven compounds were isolated from Poraqueiba sericea stems and identified as niga-ichigoside-F1 (1), trachelosperoside B1 (2), 4-epi-niga-ichigoside (7), 19α-hydroxyasiatic acid (3), myrianthic acid (4), hyptatic acid (5), trachelosperogenin B (6), arjunolic acid (8), and trachelosperogenin E (9), secologanoside (10) and secoxyloganin (11). Compounds 1-11 were tested for their antileishmanial activities against Leishmania infantum promastigotes, 1-6 and 8-11 were tested for their cytotoxic activities on fibroblasts, 1-3, 5-6, 8-11 were evaluated for their anti-elastase and anti-acetylcholinesterase assays activities by a spectrophotometric method and 1-2, 5 and 7-10 were tested using bioautography for their β-glucosidase. No antileishmanial activity was detected; compounds 1, 2 and 11 showed a moderate cytotoxic activity with IC5017.7, 20.5 and 10.9 μg/mL, respectively; compounds 2, 8, 9 and 10 gave a percentage of inhibition ranging from 13 to 16% (at 50 μg/mL) and compounds 1 and 2 showed an inhibition zone on β-glucosidase and anti-acetylcholinesterase assays.
authors.affiliation: a Institut de Chimie Moléculaire de Reims UMR 7312 CNRS , Université de Reims , Reims , France.
authors.forename: Ilhem
authors.initials: I
authors.lastname: Zebiri
authors.affiliation: b UMR 152 Pharma Dev , Université de Toulouse, IRD, UPS , Toulouse , France.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Haddad
authors.affiliation: c Unité Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), UMR CNRS 7369 , Université de Reims , Reims , France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Duca
authors.affiliation: b UMR 152 Pharma Dev , Université de Toulouse, IRD, UPS , Toulouse , France.
authors.forename: Michel
authors.initials: M
authors.lastname: Sauvain
authors.affiliation: d CNRS , LCC (Laboratoire de Chimie de Coordination) , Toulouse , France.|e Université de Toulouse, UPS, INPT , Toulouse , France.
authors.forename: Lucie
authors.initials: L
authors.lastname: Paloque
authors.affiliation: f Instituto de Investigaciones de la Amazonía Peruana (IIAP) , Iquitos , Perú.
authors.forename: Billy
authors.initials: B
authors.lastname: Cabanillas
authors.affiliation: f Instituto de Investigaciones de la Amazonía Peruana (IIAP) , Iquitos , Perú.
authors.forename: Elsa
authors.initials: E
authors.lastname: Rengifo
authors.affiliation: a Institut de Chimie Moléculaire de Reims UMR 7312 CNRS , Université de Reims , Reims , France.
authors.forename: Jean-Bernard
authors.initials: JB
authors.lastname: Behr
authors.affiliation: a Institut de Chimie Moléculaire de Reims UMR 7312 CNRS , Université de Reims , Reims , France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Voutquenne-Nazabadioko
mesh_terms: D000110:Acetylcholinesterase / Q000187:drug effects; D000818:Animals; D006801:Humans; D018314:Leishmania infantum / Q000187:drug effects; D019684:Magnoliopsida / Q000737:chemistry*; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors; D010936:Plant Extracts / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry*; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D001617:beta-Glucosidase / Q000037:antagonists & inhibitors
chemical_list: D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; C061640:arjunolic acid; C090725:niga-ichigoside F1; D000110:Acetylcholinesterase; D001617:beta-Glucosidase; D010196:Pancreatic Elastase
keywords: Icacinaceae; Poraqueiba sericea; secoiridoids; triterpenes