title: Fabrication of Waterproof, Breathable Composite Liquid Dressing and Its Application in Diabetic Skin Ulcer Repair.
abstract: OBJECTIVE
  Diabetic patients are at increased risk of severe skin infections. Covering the wound as early as possible can prevent infection and shorten the course of treatment. In this study, the authors fabricated a waterproof and breathable composite liquid dressing (CLD) that formed a barrier to bacteria and shortened healing time of diabetic rat skin ulcers.
  
  
  METHODS
  The CLD was prepared in a formulation that, on evaporation of the liquid carrier, acts as a waterproof, breathable coating on injured skin. The coating was analyzed for water resistance, moisture vapor transmission rate (MVTR), bacterial barrier properties, sustained-release function, and biosafety. A chemically induced rat model of diabetic foot ulcers was used to examine the wound healing effect of CLD and CLD that contained Dermlin (Yensen Biotech Co, Jiangyin, Jiangsu, China). The wound healing rate, histologic changes, and epidermal growth factor expression were also evaluated.
  
  
  RESULTS
  The CLD functioned as an effective barrier against infection, was waterproof, had a suitable MVTR, and had effective biosafety. The synergistic effects of CLD and Dermlin had a rapid wound closure rate. Histologic analysis and measurement of epidermal growth factor expression through an in vivo test revealed that the possible mechanism of the CLD effects included the reduction of inflammation and promotion of cell proliferation.
  
  
  CONCLUSIONS
  Early treatment with the CLD can prevent infection. In combination with Dermlin, the CLD may promote better wound closure in diabetic skin ulcers. The authors' study suggests a novel strategy for ulcer healing.
authors.affiliation: Dong-Lin Xia, MMS, is a Research Lecturer, School of Public Health and Institute of Analytical Chemistry for Life Science, Nantong University, and the Nantong Tongda Chemicals Safety Evaluation Center Co, Ltd, Nantong, China. Yan-Pei Chen, MMS, is a Research Lecturer, Xinglin College, Nantong University, Nantong, China. Yu-Fei Wang, MMS, is a Research Assistant, School of Public Health and Institute of Analytical Chemistry for Life Science, Nantong University, Nantong, China. Xiao-Dong Li, BS, is an Associate Professor, School of Public Health, Nantong University, Nantong, China. Ning Bao, PhD, is a Research Professor, School of Public Health and Institute of Analytical Chemistry for Life Science, Nantong University, Nantong, China. Hong He, MMS, is an Associate Professor, Affiliated Hospital of Nantong University, and the Nantong Tongda Chemicals Safety Evaluation Center Co, Ltd, Nantong, China. Hai-Ying Gu, PhD, is a Research Professor, Xinglin College, Nantong University, and the Nantong Tongda Chemicals Safety Evaluation Center Co, Ltd, Nantong, China.
authors.forename: Dong-Lin
authors.initials: DL
authors.lastname: Xia
authors.forename: Yan-Pei
authors.initials: YP
authors.lastname: Chen
authors.forename: Yu-Fei
authors.initials: YF
authors.lastname: Wang
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Li
authors.forename: Ning
authors.initials: N
authors.lastname: Bao
authors.forename: Hong
authors.initials: H
authors.lastname: He
authors.forename: Hai-Ying
authors.initials: HY
authors.lastname: Gu
mesh_terms: D000818:Animals; D001458:Bandages; D001707:Biopsy, Needle; D003102:Colloids / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000150:complications*; D004195:Disease Models, Animal; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000494:pharmacology; D007150:Immunohistochemistry; D008422:Materials Testing; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012680:Sensitivity and Specificity; D012883:Skin Ulcer / Q000209:etiology* / Q000473:pathology / Q000628:therapy*; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology*
chemical_list: D003102:Colloids; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate