title: Regulatory Roles of MicroRNAs in Diabetes.
abstract: MicroRNAs (miRNAs), a class of endogenous small noncoding RNAs in eukaryotes, have been recognized as significant regulators of gene expression through post-transcriptional mechanisms. To date, >2000 miRNAs have been identified in the human genome, and they orchestrate a variety of biological and pathological processes. Disruption of miRNA levels correlates with many diseases, including diabetes mellitus, a complex multifactorial metabolic disorder affecting >400 million people worldwide. miRNAs are involved in the pathogenesis of diabetes mellitus by affecting pancreatic β-cell functions, insulin resistance, or both. In this review, we summarize the investigations of the regulatory roles of important miRNAs in diabetes, as well as the potential of circulating miRNAs as diagnostic markers for diabetes mellitus.
authors.affiliation: Medical Systems Biology Research Center, School of Medicine, Tsinghua University, Beijing 100084, China. fengjuansdu@126.com.
authors.forename: Juan
authors.initials: J
authors.lastname: Feng
authors.affiliation: Medical Systems Biology Research Center, School of Medicine, Tsinghua University, Beijing 100084, China. wlxing@tsinghua.edu.cn.|National Engineering Research Center for Beijing Biochip Technology, Beijing 102206, China. wlxing@tsinghua.edu.cn.
authors.forename: Wanli
authors.initials: W
authors.lastname: Xing
authors.affiliation: Medical Systems Biology Research Center, School of Medicine, Tsinghua University, Beijing 100084, China. xielan@tsinghua.edu.cn.|National Engineering Research Center for Beijing Biochip Technology, Beijing 102206, China. xielan@tsinghua.edu.cn.
authors.forename: Lan
authors.initials: L
authors.lastname: Xie
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D003920:Diabetes Mellitus / Q000235:genetics* / Q000473:pathology*; D051275:Glucose Transporter Type 4 / Q000378:metabolism; D006801:Humans; D055504:Insulin Receptor Substrate Proteins / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology*; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D051379:Mice; D035683:MicroRNAs / Q000235:genetics*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D011972:Receptor, Insulin / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D051275:Glucose Transporter Type 4; C526292:IRS1 protein, human; C526297:IRS2 protein, human; D055504:Insulin Receptor Substrate Proteins; D035683:MicroRNAs; C495692:SLC2A4 protein, human; D019869:Phosphatidylinositol 3-Kinases; C435941:INSR protein, human; D011972:Receptor, Insulin
keywords: circulating miRNAs; diabetes; insulin resistance; miRNAs; β-cell function