title: Orchestrating cellular signaling pathways-the cellular "conductor" protein tyrosine phosphatase interacting protein 51 (PTPIP51).
abstract: The protein tyrosine phosphatase interacting protein 51 (PTPIP51) is thought to regulate crucial cellular functions such as mitosis, apoptosis, migration, differentiation and communication between organelles as a scaffold protein. These diverse functions are modulated by the tyrosine/serine phosphorylation status of PTPIP51. This review interconnects the insights obtained about the action of PTPIP51 in mitogen-activated protein kinase signaling, nuclear factor kB signaling, calcium homeostasis and chromosomal segregation and identifies important signaling hubs. The interference of PTPIP51 in such multiprotein complexes and their PTPIP51-modulated cross-talk makes PTPIP51 an ideal target for novel drugs such as the small molecule LDC-3. Graphical Abstract ᅟ.
authors.affiliation: Institute of Anatomy and Cell Biology, Justus-Liebig-University, 35392, Giessen, Germany. alexander.brobeil@patho.med.uni-giessen.de.|Institute of Pathology, Justus-Liebig-University, 35392, Giessen, Germany. alexander.brobeil@patho.med.uni-giessen.de.
authors.forename: Alexander
authors.initials: A
authors.lastname: Brobeil
authors.affiliation: Institute of Anatomy and Cell Biology, Justus-Liebig-University, 35392, Giessen, Germany.
authors.forename: Eric
authors.initials: E
authors.lastname: Dietel
authors.affiliation: Institute of Pathology, Justus-Liebig-University, 35392, Giessen, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Gattenlöhner
authors.affiliation: Institute of Anatomy and Cell Biology, Justus-Liebig-University, 35392, Giessen, Germany.
authors.forename: Monika
authors.initials: M
authors.lastname: Wimmer
mesh_terms: D000818:Animals; D002451:Cell Compartmentation; D006801:Humans; D024101:Mitochondrial Proteins / Q000378:metabolism*; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D024101:Mitochondrial Proteins; D020928:Mitogen-Activated Protein Kinases; D017027:Protein Tyrosine Phosphatases; C515449:RMDN3 protein, human
keywords: LDC-3; Mitogen activated protein kinase (MAPK) pathway; Protein complexes; Protein tyrosine phosphatase interacting protein 51 (PTPIP51); Protein-protein interaction (PPI)