title: Prognostic value of Zinc-finger protein X-linked in patients with solid tumors.
abstract: BACKGROUND
  Many studies recently suggested that Zinc-finger protein X-linked (ZFX) acted as a novel oncoprotein in various malignancies. It was frequently overexpressed in cancerous tissues and the high expression of ZFX may have important clinical value. This meta-analysis aims to investigate the prognostic value of ZFX as a biomarker of solid cancers.
  
  
  METHODS
  We search for multiple databases, including Pubmed, Springer, Web of Science, CNKI from 1996 to Sep. 1, 2016. Eligible articles were collected to explore the association between the expression levels of ZFX and overall survival (OS).
  
  
  RESULTS
  There were totally 933 cancer patients from eight studies. The pooled results indicated that cancer patients with high ZFX expression have shorter overall survival times (HR=2.26, 95%CI:1.77-2.75, P=0.000) than those with low ZFX expression. Statistical significance was also observed in subgroup meta-analysis stratified in the sampling object and cancer type.
  
  
  CONCLUSIONS
  High expression of ZFX correlated with poor clinical outcome, ZFX might be sever as a potential prognostic biomarker in various cancers, especially for colorectal cancer.
authors.affiliation: Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Nanchang University, Nanchang, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Dai
authors.affiliation: Department of Radiotherapy, Jiangxi Cancer Hospital, Nanchang, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Dong
authors.affiliation: Nanchang University School of Public Health, Nanchang, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Lu
authors.affiliation: Department of Gastrointestinal Surgery, the Second Affiliated Hospital of Nanchang University, Nanchang, China.
authors.forename: Fang T
authors.initials: FT
authors.lastname: Liu
authors.affiliation: Department of Gastrointestinal Surgery, the Second Affiliated Hospital of Nanchang University, Nanchang, China - zzm8654@163.com.
authors.forename: Zheng M
authors.initials: ZM
authors.lastname: Zhu
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000378:metabolism*; D015201:Meta-Analysis as Topic; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000401:mortality; D011237:Predictive Value of Tests; D011379:Prognosis; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D051741:Kruppel-Like Transcription Factors; C062076:zinc finger protein, X-linked