title: Integrase strand transfer inhibitor-associated diabetes mellitus: A case report.
abstract: Integrase strand transfer inhibitors (INSTIs) have become integral antiretroviral therapy (ART) agents for treating HIV infection. We report the case of a 44-year-old male with a history of hemophilia A who developed diabetes mellitus four months after switching from abacavir, lamivudine, and efavirenz to abacavir, lamivudine, and raltegravir. Hemoglobin A1C normalized without further need for exogenous insulin after raltegravir was switched back to efavirenz. In this case report, we will review a possible mechanism for INSTI-induced hyperglycemia and/or diabetes mellitus.
authors.affiliation: Oregon Health & Science University, Portland, OR, USA.
authors.forename: Peter S
authors.initials: PS
authors.lastname: Fong
authors.affiliation: Oregon Health & Science University, Portland, OR, USA.
authors.forename: Devon M
authors.initials: DM
authors.lastname: Flynn
authors.affiliation: Oregon Health & Science University, Portland, OR, USA.
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Evans
authors.affiliation: Oregon Health & Science University, Portland, OR, USA.
authors.forename: P Todd
authors.initials: PT
authors.lastname: Korthuis
mesh_terms: D000328:Adult; D003920:Diabetes Mellitus / Q000139:chemically induced* / Q000473:pathology*; D015224:Dideoxynucleosides / Q000008:administration & dosage / Q000009:adverse effects; D004338:Drug Combinations; D006442:Glycated Hemoglobin / Q000032:analysis; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D019428:HIV Integrase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D019259:Lamivudine / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D000068898:Raltegravir Potassium / Q000008:administration & dosage / Q000009:adverse effects; D000099227:Abacavir
chemical_list: D015224:Dideoxynucleosides; D004338:Drug Combinations; D006442:Glycated Hemoglobin; D019428:HIV Integrase Inhibitors; D019259:Lamivudine; D000068898:Raltegravir Potassium; C492871:abacavir, lamivudine drug combination; D000099227:Abacavir; C517652:hemoglobin A1c protein, human
keywords: HIV; Integrase inhibitors; diabetes mellitus; raltegravir