title: Zirconium-Based Porphyrinic Metal-Organic Framework (PCN-222): Enhanced Photoelectrochemical Response and Its Application for Label-Free Phosphoprotein Detection.
abstract: A simple and rapid photoelectrochemical (PEC) sensor was developed for the label-free detection of a phosphoprotein (α-casein) based on a zirconium based porphyrinic metal-organic framework (MOF), PCN-222, which exhibited an enhanced photocurrent response toward dopamine under the O2-saturated aqueous media. In this work, in terms of PEC measurements and cyclic voltammetry, the PEC behaviors of PCN-222 in aqueous media were thoroughly investigated for the first time. Additionally, in the virtue of the steric hindrance effect from the coordination of the phosphate groups and inorganic Zr-O clusters as binding sites in PCN-222, this biosensor showed high sensitivity for detecting α-casein and the limit of detection (LOD) was estimated to be 0.13 μg mL-1. Moreover, the proposed method provides a promising platform for clinic diagnostic and therapeutics.
authors.affiliation: Sino-French Laboratory of Biomaterials and Bioanalytical Chemistry, School of Environmental and Biological Engineering, Nanjing University of Science and Technology , Nanjing 210094, China.
authors.forename: Guang-Yao
authors.initials: GY
authors.lastname: Zhang
authors.affiliation: Department of Gynecology and Obstetrics, Zhongda Hospotal, Southeast University , Nanjing 210009, China.
authors.forename: Yu-Hong
authors.initials: YH
authors.lastname: Zhuang
authors.affiliation: Sino-French Laboratory of Biomaterials and Bioanalytical Chemistry, School of Environmental and Biological Engineering, Nanjing University of Science and Technology , Nanjing 210094, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Shan
authors.affiliation: Department of Gynecology and Obstetrics, Zhongda Hospotal, Southeast University , Nanjing 210009, China.
authors.forename: Guo-Fang
authors.initials: GF
authors.lastname: Su
authors.affiliation: University of Grenoble Alpes-CNRS , DCM UMR 5250, F-38000 Grenoble, France.
authors.forename: Serge
authors.initials: S
authors.lastname: Cosnier
authors.affiliation: Sino-French Laboratory of Biomaterials and Bioanalytical Chemistry, School of Environmental and Biological Engineering, Nanjing University of Science and Technology , Nanjing 210094, China.
authors.forename: Xue-Ji
authors.initials: XJ
authors.lastname: Zhang
mesh_terms: D015374:Biosensing Techniques; D055664:Electrochemical Techniques; D057230:Limit of Detection; D000073396:Metal-Organic Frameworks / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry; D010316:Particle Size; D010750:Phosphoproteins / Q000032:analysis*; D055668:Photochemical Processes; D011166:Porphyrins / Q000737:chemistry*; D013499:Surface Properties; D015040:Zirconium / Q000737:chemistry*
chemical_list: D000073396:Metal-Organic Frameworks; D010750:Phosphoproteins; D011166:Porphyrins; D015040:Zirconium; D010100:Oxygen