title: Effect of Supragingival Irrigation with Aerosolized 0.5% Hydrogen Peroxide on Clinical Periodontal Parameters, Markers of Systemic Inflammation, and Morphology of Gingival Tissues in Patients with Periodontitis.
abstract: BACKGROUND Various studies have shown that non-surgical periodontal treatment is correlated with reduction in clinical parameters and plasma levels of inflammatory markers. The aim of this study was to evaluate the effect of long-term weekly supragingival irrigations with aerosolized 0.5% hydrogen peroxide as maintenance therapy followed by non-surgical periodontal treatment on clinical parameters, plasma levels of inflammatory markers, and morphological changes in gingival tissues of patients with periodontitis. MATERIAL AND METHODS In total, 43 patients with chronic periodontitis were randomly allocated to long-term maintenance therapy. The patients' periodontal status was assessed using clinical parameters of approximal plaque index, modified gingival index, bleeding index, pocket probing depth, and plasma levels of inflammatory markers (high-sensitivity C-reactive protein and white blood cell count) at baseline and after 1, 2, and 3 years. The morphological status of gingival tissues (immediately after supragingival irrigation) was assessed microscopically. RESULTS Complete data were obtained on 34 patients. A highly statistically significant and consistent reduction was observed in all long-term clinical parameters and plasma levels of inflammatory markers. Morphological data showed abundant spherical bubbles in gingival tissues. CONCLUSIONS 1. The present study showed that non-surgical periodontal treatment with long-term weekly supragingival irrigations with aerosolized 0.5% hydrogen peroxide improved clinical periodontal status and plasma levels of inflammatory markers and may be a promising method in periodontology. 2. We found that supragingival irrigation with aerosolized 0.5% hydrogen peroxide created large numbers of spherical bubbles in gingival tissues.
authors.affiliation: Clinic of Dental and Maxillofacial Orthopedics, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Gediminas
authors.initials: G
authors.lastname: Žekonis
authors.affiliation: Clinic of Dental and Maxillofacial Orthopedics, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Jonas
authors.initials: J
authors.lastname: Žekonis
authors.affiliation: Clinic of Dental and Maxillofacial Orthopedics, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Alvydas
authors.initials: A
authors.lastname: Gleiznys
authors.affiliation: Clinic of Dental and Maxillofacial Orthopedics, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Viktorija
authors.initials: V
authors.lastname: Noreikienė
authors.affiliation: Department of Histology and Embryology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Ingrida
authors.initials: I
authors.lastname: Balnytė
authors.affiliation: Clinic of Dental and Oral Pathology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Renata
authors.initials: R
authors.lastname: Šadzevičienė
authors.affiliation: Clinic of Oral Health and Pediatric Dentistry, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Julija
authors.initials: J
authors.lastname: Narbutaitė
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D055113:Chronic Periodontitis / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D003774:Dental Plaque Index; D005260:Female; D005881:Gingiva / Q000166:cytology / Q000473:pathology; D006801:Humans; D006861:Hydrogen Peroxide / Q000008:administration & dosage*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009910:Oral Hygiene; D010512:Periodontal Index; D007507:Therapeutic Irrigation / Q000379:methods
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D006861:Hydrogen Peroxide