title: Hip fracture risk and use of proton-pump inhibitors.
abstract: Among the most commonly used drugs to treat heartburn, gastroesophageal reflux or peptic ulcers are proton-pump inhibitors. Although short-term use is well tolerated, concern has grown about association between long-term use and hip fractures. This may be because they inhibit calcium absorption, interfere with osteoclasts, which are responsible for bone re-modelling, or affect the parathyroid's ability to maintain bone mineral density.