title: Selectivity Enhancement in Molecularly Imprinted Polymers for Binding of Bisphenol A.
abstract: Bisphenol A (BPA) is an estrogen-mimicking chemical that can be selectively detected in water using a chemical sensor based on molecularly imprinted polymers (MIPs). However, the utility of BPA-MIPs in sensor applications is limited by the presence of non-specific binding sites. This study explored a dual approach to eliminating these sites: optimizing the molar ratio of the template (bisphenol A) to functional monomer (methacrylic acid) to cross-linker (ethylene glycol dimethacrylate), and esterifying the carboxylic acid residues outside of specific binding sites by treatment with diazomethane. The binding selectivity of treated MIPs and non-treated MIPs for BPA and several potential interferents was compared by capillary electrophoresis with ultraviolet detection. Baclofen, diclofenac and metformin were demonstrated to be good model interferents to test all MIPs for selective binding of BPA. Treated MIPs demonstrated a significant decrease in binding of the interferents while offering high selectivity toward BPA. These results demonstrate that conventional optimization of the molar ratio, together with advanced esterification of non-specific binding sites, effectively minimizes the residual binding of interferents with MIPs to facilitate BPA sensing.
authors.affiliation: Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON K1S 5B6, Canada. noof0988@hotmail.com.
authors.forename: Noof A
authors.initials: NA
authors.lastname: Alenazi
authors.affiliation: Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON K1S 5B6, Canada. jeff.manthorpe@carleton.ca.
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Manthorpe
authors.affiliation: Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON K1S 5B6, Canada. edward.lai@carleton.ca.
authors.forename: Edward P C
authors.initials: EP
authors.lastname: Lai
mesh_terms: D001418:Baclofen / Q000032:analysis / Q000737:chemistry; D001559:Benzhydryl Compounds / Q000032:analysis / Q000737:chemistry*; D004008:Diclofenac / Q000032:analysis / Q000737:chemistry; D019075:Electrophoresis, Capillary; D008687:Metformin / Q000032:analysis / Q000737:chemistry; D054802:Molecular Imprinting / Q000379:methods*; D010636:Phenols / Q000032:analysis / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000737:chemistry; D000098826:Bisphenol A Compounds
chemical_list: D001418:Baclofen; D001559:Benzhydryl Compounds; D004008:Diclofenac; D008687:Metformin; D010636:Phenols; D011108:Polymers; D014874:Water Pollutants, Chemical; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: bisphenol A; diazomethane; non-specific binding sites; site-selective chemical modification; treated molecularly imprinted polymers