title: Diffusion, Perfusion, and Histopathologic Characteristics of Desmoplastic Infantile Ganglioglioma.
abstract: We present a case series of a rare tumor, the desmoplastic infantile ganglioglioma (DIG) with MRI diffusion and perfusion imaging quantification as well as histopathologic characterization. Four cases with pathologically-proven DIG had diffusion weighted imaging (DWI) and two of the four had dynamic susceptibility contrast imaging. All four tumors demonstrate DWI findings compatible with low-grade pediatric tumors. For the two cases with perfusion imaging, a higher relative cerebral blood volume was associated with higher proliferation index on histopathology for one of the cases. Our results are discussed in conjunction with a literature review.
authors.affiliation: Department of Radiology, Indiana University School of Medicine, Indianapolis, USA.
authors.forename: Chang Y
authors.initials: CY
authors.lastname: Ho
authors.affiliation: Department of Pathology, Indiana University School of Medicine, Indianapolis, USA.
authors.forename: Melissa
authors.initials: M
authors.lastname: Gener
authors.affiliation: Department of Pathology, Indiana University School of Medicine, Indianapolis, USA.
authors.forename: Jose
authors.initials: J
authors.lastname: Bonnin
authors.affiliation: Department of Radiology, Indiana University School of Medicine, Indianapolis, USA.
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Kralik
mesh_terms: D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D003287:Contrast Media; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D018303:Ganglioglioma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007223:Infant; D008297:Male; D008536:Meglumine / Q000031:analogs & derivatives; D009942:Organometallic Compounds
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine
keywords: MRI; desmoplastic infantile ganglioglioma; diffusion; pediatric brain tumors; perfusion