title: Regioselective β-silylation of porphyrins via iridium-catalyzed C-H bond activation.
abstract: An efficient approach to meso-unsubstituted β-silylporphyrins was developed through highly regioselective Ir-catalyzed C-H activation, in the presence of HSiMe(OSiMe3)2as the Si source, from meso-unsubstituted porphyrins. Further transformations of the silyl group, such as oxidation, halogenation, and cross-coupling reactions, could be achieved under mild conditions, demonstrating the synthetic utility of β-silylporphyrins as a multipurpose synthon for fabricating porphyrin derivatives.
authors.affiliation: Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo 204-8588, Japan. takanami@my-pharm.ac.jp.
authors.forename: Noriaki
authors.initials: N
authors.lastname: Sugita
authors.affiliation: Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo 204-8588, Japan. takanami@my-pharm.ac.jp.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hayashi
authors.affiliation: Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo 204-8588, Japan. takanami@my-pharm.ac.jp.
authors.forename: Masashi
authors.initials: M
authors.lastname: Shibata
authors.affiliation: Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo 204-8588, Japan. takanami@my-pharm.ac.jp.
authors.forename: Taiga
authors.initials: T
authors.lastname: Endo
authors.affiliation: Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo 204-8588, Japan. takanami@my-pharm.ac.jp.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Noji
authors.affiliation: Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo 204-8588, Japan. takanami@my-pharm.ac.jp.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Takatori
authors.affiliation: Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo 204-8588, Japan. takanami@my-pharm.ac.jp.
authors.forename: Toshikatsu
authors.identifier: http://orcid.org/0000-0002-9661-3965
authors.initials: T
authors.lastname: Takanami