title: Combination of Thrombolysis and Statins in Acute Stroke Is Safe: Results of the STARS Randomized Trial (Stroke Treatment With Acute Reperfusion and Simvastatin).
abstract: The STARS trial (Stroke Treatment With Acute Reperfusion and Simvastatin) was conducted to demonstrate the efficacy and safety of simvastatin treatment in acute stroke.
  
  
  
  STARS07 was a multicentre, phase IV, prospective, randomized, double-blind, placebo-controlled trial. Patients with Acute ischemic stroke recruited within 12 hours from symptom onset were randomized to oral simvastatin 40 mg or placebo, once daily for 90 days. Primary outcome was proportion of independent patients (modified Rankin Scale score of ≤2) at 90 days. Safety end points were hemorrhagic transformation, hemorrhagic events, death, infections, and serious adverse events.
  
  
  
  From April 2009 to March 2014, 104 patients were included. Fifty-five patients received intravenous tissue-type plasminogen activator. No differences were found between treatment arms regarding the primary outcome (adjusted odds ratio, 0.99 [0.35-2.78]; P=0.98). Concerning safety, no significant differences were found in the rate of hemorrhagic transformation of any type, nor symptomatic hemorrhagic transformation. There were no differences in other predefined safety outcomes. In post hoc analyses, for patients receiving tissue-type plasminogen activator, a favorable effect for simvastatin treatment was noted with higher proportion of patients experiencing major neurological recovery (adjusted odds ratio, 4.14 [1.18-14.4]; P=0.02).
  
  
  
  Simvastatin plus tissue-type plasminogen activator combination seems safe in acute stroke, with low rates of bleeding complications. Because of the low recruitment, the STARS trial was underpowered to detect differences in simvastatin efficacy.
  
  
  
  URL: http://www.clinicaltrials.gov. Unique identifier: NCT01073007.
authors.affiliation: From the Stroke Unit, Department of Neurology (J.M., M.R.), Neurovascular Research Laboratory, Institut de Recerca-Universitat Autónoma de Barcelona (J.M., A.B., N.C., D.G., P.D.), and Vall d' Hebron Institut d'Oncologia (S.G.-M.), Hospital Universitari Vall d'Hebron, Barcelona, Spain; Neurovascular Unit, Department of Neurology, Hospital Universitario Donostia, Donostia-San Sebastian, Spain (M.M.-Z., A.A.); Department of Neurology, Hospital Universitari Son Espases, Palma de Mallorca, Spain (C.J., B.V.-P.); Stroke Program, Institute of Biomedicine of Seville, Hospital Universitario Virgen del Rocio, Seville, Spain (J.T., F.M.); Department of Neurology, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain (F.R.R.); Department of Neurology, Hospital Universitario Virgen de la Victoria, Albacete, Spain (T.S.); Stroke Unit, Department of Neurology, IRYCIS, University Hospital Ramón y Cajal, Madrid, Spain (J.M.); Department of Neurology, Hospital Universitari Parc Tauli, Sabadell, Spain (D.C.); Department of Neurology, Hospital de Basurto, Bilbao, Spain (M.F.); Department of Neurology, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain (R.D.-M.); Department of Neurology, Hospital Universitario de León, Spain (J.T.); Stroke Unit, Department of Neurology, Hospital Universitari la Fe, Valencia, Spain (A.L.); and Department of Neurology, Hospital Universitari General Yagüe, Burgos, Spain (Y.B.). joan.montaner@vhir.org.
authors.forename: Joan
authors.initials: J
authors.lastname: Montaner
authors.affiliation: From the Stroke Unit, Department of Neurology (J.M., M.R.), Neurovascular Research Laboratory, Institut de Recerca-Universitat Autónoma de Barcelona (J.M., A.B., N.C., D.G., P.D.), and Vall d' Hebron Institut d'Oncologia (S.G.-M.), Hospital Universitari Vall d'Hebron, Barcelona, Spain; Neurovascular Unit, Department of Neurology, Hospital Universitario Donostia, Donostia-San Sebastian, Spain (M.M.-Z., A.A.); Department of Neurology, Hospital Universitari Son Espases, Palma de Mallorca, Spain (C.J., B.V.-P.); Stroke Program, Institute of Biomedicine of Seville, Hospital Universitario Virgen del Rocio, Seville, Spain (J.T., F.M.); Department of Neurology, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain (F.R.R.); Department of Neurology, Hospital Universitario Virgen de la Victoria, Albacete, Spain (T.S.); Stroke Unit, Department of Neurology, IRYCIS, University Hospital Ramón y Cajal, Madrid, Spain (J.M.); Department of Neurology, Hospital Universitari Parc Tauli, Sabadell, Spain (D.C.); Department of Neurology, Hospital de Basurto, Bilbao, Spain (M.F.); Department of Neurology, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain (R.D.-M.); Department of Neurology, Hospital Universitario de León, Spain (J.T.); Stroke Unit, Department of Neurology, Hospital Universitari la Fe, Valencia, Spain (A.L.); and Department of Neurology, Hospital Universitari General Yagüe, Burgos, Spain (Y.B.).
authors.forename: Alejandro
authors.initials: A
authors.lastname: Bustamante
authors.affiliation: From the Stroke Unit, Department of Neurology (J.M., M.R.), Neurovascular Research Laboratory, Institut de Recerca-Universitat Autónoma de Barcelona (J.M., A.B., N.C., D.G., P.D.), and Vall d' Hebron Institut d'Oncologia (S.G.-M.), Hospital Universitari Vall d'Hebron, Barcelona, Spain; Neurovascular Unit, Department of Neurology, Hospital Universitario Donostia, Donostia-San Sebastian, Spain (M.M.-Z., A.A.); Department of Neurology, Hospital Universitari Son Espases, Palma de Mallorca, Spain (C.J., B.V.-P.); Stroke Program, Institute of Biomedicine of Seville, Hospital Universitario Virgen del Rocio, Seville, Spain (J.T., F.M.); Department of Neurology, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain (F.R.R.); Department of Neurology, Hospital Universitario Virgen de la Victoria, Albacete, Spain (T.S.); Stroke Unit, Department of Neurology, IRYCIS, University Hospital Ramón y Cajal, Madrid, Spain (J.M.); Department of Neurology, Hospital Universitari Parc Tauli, Sabadell, Spain (D.C.); Department of Neurology, Hospital de Basurto, Bilbao, Spain (M.F.); Department of Neurology, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain (R.D.-M.); Department of Neurology, Hospital Universitario de León, Spain (J.T.); Stroke Unit, Department of Neurology, Hospital Universitari la Fe, Valencia, Spain (A.L.); and Department of Neurology, Hospital Universitari General Yagüe, Burgos, Spain (Y.B.).
authors.forename: Silvia
authors.initials: S
authors.lastname: García-Matas
authors.affiliation: From the Stroke Unit, Department of Neurology (J.M., M.R.), Neurovascular Research Laboratory, Institut de Recerca-Universitat Autónoma de Barcelona (J.M., A.B., N.C., D.G., P.D.), and Vall d' Hebron Institut d'Oncologia (S.G.-M.), Hospital Universitari Vall d'Hebron, Barcelona, Spain; Neurovascular Unit, Department of Neurology, Hospital Universitario Donostia, Donostia-San Sebastian, Spain (M.M.-Z., A.A.); Department of Neurology, Hospital Universitari Son Espases, Palma de Mallorca, Spain (C.J., B.V.-P.); Stroke Program, Institute of Biomedicine of Seville, Hospital Universitario Virgen del Rocio, Seville, Spain (J.T., F.M.); Department of Neurology, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain (F.R.R.); Department of Neurology, Hospital Universitario Virgen de la Victoria, Albacete, Spain (T.S.); Stroke Unit, Department of Neurology, IRYCIS, University Hospital Ramón y Cajal, Madrid, Spain (J.M.); Department of Neurology, Hospital Universitari Parc Tauli, Sabadell, Spain (D.C.); Department of Neurology, Hospital de Basurto, Bilbao, Spain (M.F.); Department of Neurology, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain (R.D.-M.); Department of Neurology, Hospital Universitario de León, Spain (J.T.); Stroke Unit, Department of Neurology, Hospital Universitari la Fe, Valencia, Spain (A.L.); and Department of Neurology, Hospital Universitari General Yagüe, Burgos, Spain (Y.B.).
authors.forename: Maite
authors.initials: M
authors.lastname: Martínez-Zabaleta
authors.affiliation: From the Stroke Unit, Department of Neurology (J.M., M.R.), Neurovascular Research Laboratory, Institut de Recerca-Universitat Autónoma de Barcelona (J.M., A.B., N.C., D.G., P.D.), and Vall d' Hebron Institut d'Oncologia (S.G.-M.), Hospital Universitari Vall d'Hebron, Barcelona, Spain; Neurovascular Unit, Department of Neurology, Hospital Universitario Donostia, Donostia-San Sebastian, Spain (M.M.-Z., A.A.); Department of Neurology, Hospital Universitari Son Espases, Palma de Mallorca, Spain (C.J., B.V.-P.); Stroke Program, Institute of Biomedicine of Seville, Hospital Universitario Virgen del Rocio, Seville, Spain (J.T., F.M.); Department of Neurology, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain (F.R.R.); Department of Neurology, Hospital Universitario Virgen de la Victoria, Albacete, Spain (T.S.); Stroke Unit, Department of Neurology, IRYCIS, University Hospital Ramón y Cajal, Madrid, Spain (J.M.); Department of Neurology, Hospital Universitari Parc Tauli, Sabadell, Spain (D.C.); Department of Neurology, Hospital de Basurto, Bilbao, Spain (M.F.); Department of Neurology, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain (R.D.-M.); Department of Neurology, Hospital Universitario de León, Spain (J.T.); Stroke Unit, Department of Neurology, Hospital Universitari la Fe, Valencia, Spain (A.L.); and Department of Neurology, Hospital Universitari General Yagüe, Burgos, Spain (Y.B.).
authors.forename: Carmen
authors.initials: C
authors.lastname: Jiménez
authors.affiliation: From the Stroke Unit, Department of Neurology (J.M., M.R.), Neurovascular Research Laboratory, Institut de Recerca-Universitat Autónoma de Barcelona (J.M., A.B., N.C., D.G., P.D.), and Vall d' Hebron Institut d'Oncologia (S.G.-M.), Hospital Universitari Vall d'Hebron, Barcelona, Spain; Neurovascular Unit, Department of Neurology, Hospital Universitario Donostia, Donostia-San Sebastian, Spain (M.M.-Z., A.A.); Department of Neurology, Hospital Universitari Son Espases, Palma de Mallorca, Spain (C.J., B.V.-P.); Stroke Program, Institute of Biomedicine of Seville, Hospital Universitario Virgen del Rocio, Seville, Spain (J.T., F.M.); Department of Neurology, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain (F.R.R.); Department of Neurology, Hospital Universitario Virgen de la Victoria, Albacete, Spain (T.S.); Stroke Unit, Department of Neurology, IRYCIS, University Hospital Ramón y Cajal, Madrid, Spain (J.M.); Department of Neurology, Hospital Universitari Parc Tauli, Sabadell, Spain (D.C.); Department of Neurology, Hospital de Basurto, Bilbao, Spain (M.F.); Department of Neurology, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain (R.D.-M.); Department of Neurology, Hospital Universitario de León, Spain (J.T.); Stroke Unit, Department of Neurology, Hospital Universitari la Fe, Valencia, Spain (A.L.); and Department of Neurology, Hospital Universitari General Yagüe, Burgos, Spain (Y.B.).
authors.forename: Javier
authors.initials: J
authors.lastname: de la Torre
authors.affiliation: From the Stroke Unit, Department of Neurology (J.M., M.R.), Neurovascular Research Laboratory, Institut de Recerca-Universitat Autónoma de Barcelona (J.M., A.B., N.C., D.G., P.D.), and Vall d' Hebron Institut d'Oncologia (S.G.-M.), Hospital Universitari Vall d'Hebron, Barcelona, Spain; Neurovascular Unit, Department of Neurology, Hospital Universitario Donostia, Donostia-San Sebastian, Spain (M.M.-Z., A.A.); Department of Neurology, Hospital Universitari Son Espases, Palma de Mallorca, Spain (C.J., B.V.-P.); Stroke Program, Institute of Biomedicine of Seville, Hospital Universitario Virgen del Rocio, Seville, Spain (J.T., F.M.); Department of Neurology, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain (F.R.R.); Department of Neurology, Hospital Universitario Virgen de la Victoria, Albacete, Spain (T.S.); Stroke Unit, Department of Neurology, IRYCIS, University Hospital Ramón y Cajal, Madrid, Spain (J.M.); Department of Neurology, Hospital Universitari Parc Tauli, Sabadell, Spain (D.C.); Department of Neurology, Hospital de Basurto, Bilbao, Spain (M.F.); Department of Neurology, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain (R.D.-M.); Department of Neurology, Hospital Universitario de León, Spain (J.T.); Stroke Unit, Department of Neurology, Hospital Universitari la Fe, Valencia, Spain (A.L.); and Department of Neurology, Hospital Universitari General Yagüe, Burgos, Spain (Y.B.).
authors.forename: Francisco R
authors.initials: FR
authors.lastname: Rubio
authors.affiliation: From the Stroke Unit, Department of Neurology (J.M., M.R.), Neurovascular Research Laboratory, Institut de Recerca-Universitat Autónoma de Barcelona (J.M., A.B., N.C., D.G., P.D.), and Vall d' Hebron Institut d'Oncologia (S.G.-M.), Hospital Universitari Vall d'Hebron, Barcelona, Spain; Neurovascular Unit, Department of Neurology, Hospital Universitario Donostia, Donostia-San Sebastian, Spain (M.M.-Z., A.A.); Department of Neurology, Hospital Universitari Son Espases, Palma de Mallorca, Spain (C.J., B.V.-P.); Stroke Program, Institute of Biomedicine of Seville, Hospital Universitario Virgen del Rocio, Seville, Spain (J.T., F.M.); Department of Neurology, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain (F.R.R.); Department of Neurology, Hospital Universitario Virgen de la Victoria, Albacete, Spain (T.S.); Stroke Unit, Department of Neurology, IRYCIS, University Hospital Ramón y Cajal, Madrid, Spain (J.M.); Department of Neurology, Hospital Universitari Parc Tauli, Sabadell, Spain (D.C.); Department of Neurology, Hospital de Basurto, Bilbao, Spain (M.F.); Department of Neurology, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain (R.D.-M.); Department of Neurology, Hospital Universitario de León, Spain (J.T.); Stroke Unit, Department of Neurology, Hospital Universitari la Fe, Valencia, Spain (A.L.); and Department of Neurology, Hospital Universitari General Yagüe, Burgos, Spain (Y.B.).
authors.forename: Tomás
authors.initials: T
authors.lastname: Segura
authors.affiliation: From the Stroke Unit, Department of Neurology (J.M., M.R.), Neurovascular Research Laboratory, Institut de Recerca-Universitat Autónoma de Barcelona (J.M., A.B., N.C., D.G., P.D.), and Vall d' Hebron Institut d'Oncologia (S.G.-M.), Hospital Universitari Vall d'Hebron, Barcelona, Spain; Neurovascular Unit, Department of Neurology, Hospital Universitario Donostia, Donostia-San Sebastian, Spain (M.M.-Z., A.A.); Department of Neurology, Hospital Universitari Son Espases, Palma de Mallorca, Spain (C.J., B.V.-P.); Stroke Program, Institute of Biomedicine of Seville, Hospital Universitario Virgen del Rocio, Seville, Spain (J.T., F.M.); Department of Neurology, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain (F.R.R.); Department of Neurology, Hospital Universitario Virgen de la Victoria, Albacete, Spain (T.S.); Stroke Unit, Department of Neurology, IRYCIS, University Hospital Ramón y Cajal, Madrid, Spain (J.M.); Department of Neurology, Hospital Universitari Parc Tauli, Sabadell, Spain (D.C.); Department of Neurology, Hospital de Basurto, Bilbao, Spain (M.F.); Department of Neurology, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain (R.D.-M.); Department of Neurology, Hospital Universitario de León, Spain (J.T.); Stroke Unit, Department of Neurology, Hospital Universitari la Fe, Valencia, Spain (A.L.); and Department of Neurology, Hospital Universitari General Yagüe, Burgos, Spain (Y.B.).
authors.forename: Jaime
authors.initials: J
authors.lastname: Masjuán
authors.affiliation: From the Stroke Unit, Department of Neurology (J.M., M.R.), Neurovascular Research Laboratory, Institut de Recerca-Universitat Autónoma de Barcelona (J.M., A.B., N.C., D.G., P.D.), and Vall d' Hebron Institut d'Oncologia (S.G.-M.), Hospital Universitari Vall d'Hebron, Barcelona, Spain; Neurovascular Unit, Department of Neurology, Hospital Universitario Donostia, Donostia-San Sebastian, Spain (M.M.-Z., A.A.); Department of Neurology, Hospital Universitari Son Espases, Palma de Mallorca, Spain (C.J., B.V.-P.); Stroke Program, Institute of Biomedicine of Seville, Hospital Universitario Virgen del Rocio, Seville, Spain (J.T., F.M.); Department of Neurology, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain (F.R.R.); Department of Neurology, Hospital Universitario Virgen de la Victoria, Albacete, Spain (T.S.); Stroke Unit, Department of Neurology, IRYCIS, University Hospital Ramón y Cajal, Madrid, Spain (J.M.); Department of Neurology, Hospital Universitari Parc Tauli, Sabadell, Spain (D.C.); Department of Neurology, Hospital de Basurto, Bilbao, Spain (M.F.); Department of Neurology, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain (R.D.-M.); Department of Neurology, Hospital Universitario de León, Spain (J.T.); Stroke Unit, Department of Neurology, Hospital Universitari la Fe, Valencia, Spain (A.L.); and Department of Neurology, Hospital Universitari General Yagüe, Burgos, Spain (Y.B.).
authors.forename: David
authors.initials: D
authors.lastname: Cánovas
authors.affiliation: From the Stroke Unit, Department of Neurology (J.M., M.R.), Neurovascular Research Laboratory, Institut de Recerca-Universitat Autónoma de Barcelona (J.M., A.B., N.C., D.G., P.D.), and Vall d' Hebron Institut d'Oncologia (S.G.-M.), Hospital Universitari Vall d'Hebron, Barcelona, Spain; Neurovascular Unit, Department of Neurology, Hospital Universitario Donostia, Donostia-San Sebastian, Spain (M.M.-Z., A.A.); Department of Neurology, Hospital Universitari Son Espases, Palma de Mallorca, Spain (C.J., B.V.-P.); Stroke Program, Institute of Biomedicine of Seville, Hospital Universitario Virgen del Rocio, Seville, Spain (J.T., F.M.); Department of Neurology, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain (F.R.R.); Department of Neurology, Hospital Universitario Virgen de la Victoria, Albacete, Spain (T.S.); Stroke Unit, Department of Neurology, IRYCIS, University Hospital Ramón y Cajal, Madrid, Spain (J.M.); Department of Neurology, Hospital Universitari Parc Tauli, Sabadell, Spain (D.C.); Department of Neurology, Hospital de Basurto, Bilbao, Spain (M.F.); Department of Neurology, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain (R.D.-M.); Department of Neurology, Hospital Universitario de León, Spain (J.T.); Stroke Unit, Department of Neurology, Hospital Universitari la Fe, Valencia, Spain (A.L.); and Department of Neurology, Hospital Universitari General Yagüe, Burgos, Spain (Y.B.).
authors.forename: Mar
authors.initials: M
authors.lastname: Freijo
authors.affiliation: From the Stroke Unit, Department of Neurology (J.M., M.R.), Neurovascular Research Laboratory, Institut de Recerca-Universitat Autónoma de Barcelona (J.M., A.B., N.C., D.G., P.D.), and Vall d' Hebron Institut d'Oncologia (S.G.-M.), Hospital Universitari Vall d'Hebron, Barcelona, Spain; Neurovascular Unit, Department of Neurology, Hospital Universitario Donostia, Donostia-San Sebastian, Spain (M.M.-Z., A.A.); Department of Neurology, Hospital Universitari Son Espases, Palma de Mallorca, Spain (C.J., B.V.-P.); Stroke Program, Institute of Biomedicine of Seville, Hospital Universitario Virgen del Rocio, Seville, Spain (J.T., F.M.); Department of Neurology, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain (F.R.R.); Department of Neurology, Hospital Universitario Virgen de la Victoria, Albacete, Spain (T.S.); Stroke Unit, Department of Neurology, IRYCIS, University Hospital Ramón y Cajal, Madrid, Spain (J.M.); Department of Neurology, Hospital Universitari Parc Tauli, Sabadell, Spain (D.C.); Department of Neurology, Hospital de Basurto, Bilbao, Spain (M.F.); Department of Neurology, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain (R.D.-M.); Department of Neurology, Hospital Universitario de León, Spain (J.T.); Stroke Unit, Department of Neurology, Hospital Universitari la Fe, Valencia, Spain (A.L.); and Department of Neurology, Hospital Universitari General Yagüe, Burgos, Spain (Y.B.).
authors.forename: Raquel
authors.initials: R
authors.lastname: Delgado-Mederos
authors.affiliation: From the Stroke Unit, Department of Neurology (J.M., M.R.), Neurovascular Research Laboratory, Institut de Recerca-Universitat Autónoma de Barcelona (J.M., A.B., N.C., D.G., P.D.), and Vall d' Hebron Institut d'Oncologia (S.G.-M.), Hospital Universitari Vall d'Hebron, Barcelona, Spain; Neurovascular Unit, Department of Neurology, Hospital Universitario Donostia, Donostia-San Sebastian, Spain (M.M.-Z., A.A.); Department of Neurology, Hospital Universitari Son Espases, Palma de Mallorca, Spain (C.J., B.V.-P.); Stroke Program, Institute of Biomedicine of Seville, Hospital Universitario Virgen del Rocio, Seville, Spain (J.T., F.M.); Department of Neurology, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain (F.R.R.); Department of Neurology, Hospital Universitario Virgen de la Victoria, Albacete, Spain (T.S.); Stroke Unit, Department of Neurology, IRYCIS, University Hospital Ramón y Cajal, Madrid, Spain (J.M.); Department of Neurology, Hospital Universitari Parc Tauli, Sabadell, Spain (D.C.); Department of Neurology, Hospital de Basurto, Bilbao, Spain (M.F.); Department of Neurology, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain (R.D.-M.); Department of Neurology, Hospital Universitario de León, Spain (J.T.); Stroke Unit, Department of Neurology, Hospital Universitari la Fe, Valencia, Spain (A.L.); and Department of Neurology, Hospital Universitari General Yagüe, Burgos, Spain (Y.B.).
authors.forename: Javier
authors.initials: J
authors.lastname: Tejada
authors.affiliation: From the Stroke Unit, Department of Neurology (J.M., M.R.), Neurovascular Research Laboratory, Institut de Recerca-Universitat Autónoma de Barcelona (J.M., A.B., N.C., D.G., P.D.), and Vall d' Hebron Institut d'Oncologia (S.G.-M.), Hospital Universitari Vall d'Hebron, Barcelona, Spain; Neurovascular Unit, Department of Neurology, Hospital Universitario Donostia, Donostia-San Sebastian, Spain (M.M.-Z., A.A.); Department of Neurology, Hospital Universitari Son Espases, Palma de Mallorca, Spain (C.J., B.V.-P.); Stroke Program, Institute of Biomedicine of Seville, Hospital Universitario Virgen del Rocio, Seville, Spain (J.T., F.M.); Department of Neurology, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain (F.R.R.); Department of Neurology, Hospital Universitario Virgen de la Victoria, Albacete, Spain (T.S.); Stroke Unit, Department of Neurology, IRYCIS, University Hospital Ramón y Cajal, Madrid, Spain (J.M.); Department of Neurology, Hospital Universitari Parc Tauli, Sabadell, Spain (D.C.); Department of Neurology, Hospital de Basurto, Bilbao, Spain (M.F.); Department of Neurology, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain (R.D.-M.); Department of Neurology, Hospital Universitario de León, Spain (J.T.); Stroke Unit, Department of Neurology, Hospital Universitari la Fe, Valencia, Spain (A.L.); and Department of Neurology, Hospital Universitari General Yagüe, Burgos, Spain (Y.B.).
authors.forename: Aida
authors.initials: A
authors.lastname: Lago
authors.affiliation: From the Stroke Unit, Department of Neurology (J.M., M.R.), Neurovascular Research Laboratory, Institut de Recerca-Universitat Autónoma de Barcelona (J.M., A.B., N.C., D.G., P.D.), and Vall d' Hebron Institut d'Oncologia (S.G.-M.), Hospital Universitari Vall d'Hebron, Barcelona, Spain; Neurovascular Unit, Department of Neurology, Hospital Universitario Donostia, Donostia-San Sebastian, Spain (M.M.-Z., A.A.); Department of Neurology, Hospital Universitari Son Espases, Palma de Mallorca, Spain (C.J., B.V.-P.); Stroke Program, Institute of Biomedicine of Seville, Hospital Universitario Virgen del Rocio, Seville, Spain (J.T., F.M.); Department of Neurology, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain (F.R.R.); Department of Neurology, Hospital Universitario Virgen de la Victoria, Albacete, Spain (T.S.); Stroke Unit, Department of Neurology, IRYCIS, University Hospital Ramón y Cajal, Madrid, Spain (J.M.); Department of Neurology, Hospital Universitari Parc Tauli, Sabadell, Spain (D.C.); Department of Neurology, Hospital de Basurto, Bilbao, Spain (M.F.); Department of Neurology, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain (R.D.-M.); Department of Neurology, Hospital Universitario de León, Spain (J.T.); Stroke Unit, Department of Neurology, Hospital Universitari la Fe, Valencia, Spain (A.L.); and Department of Neurology, Hospital Universitari General Yagüe, Burgos, Spain (Y.B.).
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Bravo
authors.affiliation: From the Stroke Unit, Department of Neurology (J.M., M.R.), Neurovascular Research Laboratory, Institut de Recerca-Universitat Autónoma de Barcelona (J.M., A.B., N.C., D.G., P.D.), and Vall d' Hebron Institut d'Oncologia (S.G.-M.), Hospital Universitari Vall d'Hebron, Barcelona, Spain; Neurovascular Unit, Department of Neurology, Hospital Universitario Donostia, Donostia-San Sebastian, Spain (M.M.-Z., A.A.); Department of Neurology, Hospital Universitari Son Espases, Palma de Mallorca, Spain (C.J., B.V.-P.); Stroke Program, Institute of Biomedicine of Seville, Hospital Universitario Virgen del Rocio, Seville, Spain (J.T., F.M.); Department of Neurology, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain (F.R.R.); Department of Neurology, Hospital Universitario Virgen de la Victoria, Albacete, Spain (T.S.); Stroke Unit, Department of Neurology, IRYCIS, University Hospital Ramón y Cajal, Madrid, Spain (J.M.); Department of Neurology, Hospital Universitari Parc Tauli, Sabadell, Spain (D.C.); Department of Neurology, Hospital de Basurto, Bilbao, Spain (M.F.); Department of Neurology, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain (R.D.-M.); Department of Neurology, Hospital Universitario de León, Spain (J.T.); Stroke Unit, Department of Neurology, Hospital Universitari la Fe, Valencia, Spain (A.L.); and Department of Neurology, Hospital Universitari General Yagüe, Burgos, Spain (Y.B.).
authors.forename: Natália
authors.initials: N
authors.lastname: Corbeto
authors.affiliation: From the Stroke Unit, Department of Neurology (J.M., M.R.), Neurovascular Research Laboratory, Institut de Recerca-Universitat Autónoma de Barcelona (J.M., A.B., N.C., D.G., P.D.), and Vall d' Hebron Institut d'Oncologia (S.G.-M.), Hospital Universitari Vall d'Hebron, Barcelona, Spain; Neurovascular Unit, Department of Neurology, Hospital Universitario Donostia, Donostia-San Sebastian, Spain (M.M.-Z., A.A.); Department of Neurology, Hospital Universitari Son Espases, Palma de Mallorca, Spain (C.J., B.V.-P.); Stroke Program, Institute of Biomedicine of Seville, Hospital Universitario Virgen del Rocio, Seville, Spain (J.T., F.M.); Department of Neurology, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain (F.R.R.); Department of Neurology, Hospital Universitario Virgen de la Victoria, Albacete, Spain (T.S.); Stroke Unit, Department of Neurology, IRYCIS, University Hospital Ramón y Cajal, Madrid, Spain (J.M.); Department of Neurology, Hospital Universitari Parc Tauli, Sabadell, Spain (D.C.); Department of Neurology, Hospital de Basurto, Bilbao, Spain (M.F.); Department of Neurology, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain (R.D.-M.); Department of Neurology, Hospital Universitario de León, Spain (J.T.); Stroke Unit, Department of Neurology, Hospital Universitari la Fe, Valencia, Spain (A.L.); and Department of Neurology, Hospital Universitari General Yagüe, Burgos, Spain (Y.B.).
authors.forename: Dolors
authors.initials: D
authors.lastname: Giralt
authors.affiliation: From the Stroke Unit, Department of Neurology (J.M., M.R.), Neurovascular Research Laboratory, Institut de Recerca-Universitat Autónoma de Barcelona (J.M., A.B., N.C., D.G., P.D.), and Vall d' Hebron Institut d'Oncologia (S.G.-M.), Hospital Universitari Vall d'Hebron, Barcelona, Spain; Neurovascular Unit, Department of Neurology, Hospital Universitario Donostia, Donostia-San Sebastian, Spain (M.M.-Z., A.A.); Department of Neurology, Hospital Universitari Son Espases, Palma de Mallorca, Spain (C.J., B.V.-P.); Stroke Program, Institute of Biomedicine of Seville, Hospital Universitario Virgen del Rocio, Seville, Spain (J.T., F.M.); Department of Neurology, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain (F.R.R.); Department of Neurology, Hospital Universitario Virgen de la Victoria, Albacete, Spain (T.S.); Stroke Unit, Department of Neurology, IRYCIS, University Hospital Ramón y Cajal, Madrid, Spain (J.M.); Department of Neurology, Hospital Universitari Parc Tauli, Sabadell, Spain (D.C.); Department of Neurology, Hospital de Basurto, Bilbao, Spain (M.F.); Department of Neurology, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain (R.D.-M.); Department of Neurology, Hospital Universitario de León, Spain (J.T.); Stroke Unit, Department of Neurology, Hospital Universitari la Fe, Valencia, Spain (A.L.); and Department of Neurology, Hospital Universitari General Yagüe, Burgos, Spain (Y.B.).
authors.forename: Bárbara
authors.initials: B
authors.lastname: Vives-Pastor
authors.affiliation: From the Stroke Unit, Department of Neurology (J.M., M.R.), Neurovascular Research Laboratory, Institut de Recerca-Universitat Autónoma de Barcelona (J.M., A.B., N.C., D.G., P.D.), and Vall d' Hebron Institut d'Oncologia (S.G.-M.), Hospital Universitari Vall d'Hebron, Barcelona, Spain; Neurovascular Unit, Department of Neurology, Hospital Universitario Donostia, Donostia-San Sebastian, Spain (M.M.-Z., A.A.); Department of Neurology, Hospital Universitari Son Espases, Palma de Mallorca, Spain (C.J., B.V.-P.); Stroke Program, Institute of Biomedicine of Seville, Hospital Universitario Virgen del Rocio, Seville, Spain (J.T., F.M.); Department of Neurology, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain (F.R.R.); Department of Neurology, Hospital Universitario Virgen de la Victoria, Albacete, Spain (T.S.); Stroke Unit, Department of Neurology, IRYCIS, University Hospital Ramón y Cajal, Madrid, Spain (J.M.); Department of Neurology, Hospital Universitari Parc Tauli, Sabadell, Spain (D.C.); Department of Neurology, Hospital de Basurto, Bilbao, Spain (M.F.); Department of Neurology, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain (R.D.-M.); Department of Neurology, Hospital Universitario de León, Spain (J.T.); Stroke Unit, Department of Neurology, Hospital Universitari la Fe, Valencia, Spain (A.L.); and Department of Neurology, Hospital Universitari General Yagüe, Burgos, Spain (Y.B.).
authors.forename: Anna
authors.initials: A
authors.lastname: de Arce
authors.affiliation: From the Stroke Unit, Department of Neurology (J.M., M.R.), Neurovascular Research Laboratory, Institut de Recerca-Universitat Autónoma de Barcelona (J.M., A.B., N.C., D.G., P.D.), and Vall d' Hebron Institut d'Oncologia (S.G.-M.), Hospital Universitari Vall d'Hebron, Barcelona, Spain; Neurovascular Unit, Department of Neurology, Hospital Universitario Donostia, Donostia-San Sebastian, Spain (M.M.-Z., A.A.); Department of Neurology, Hospital Universitari Son Espases, Palma de Mallorca, Spain (C.J., B.V.-P.); Stroke Program, Institute of Biomedicine of Seville, Hospital Universitario Virgen del Rocio, Seville, Spain (J.T., F.M.); Department of Neurology, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain (F.R.R.); Department of Neurology, Hospital Universitario Virgen de la Victoria, Albacete, Spain (T.S.); Stroke Unit, Department of Neurology, IRYCIS, University Hospital Ramón y Cajal, Madrid, Spain (J.M.); Department of Neurology, Hospital Universitari Parc Tauli, Sabadell, Spain (D.C.); Department of Neurology, Hospital de Basurto, Bilbao, Spain (M.F.); Department of Neurology, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain (R.D.-M.); Department of Neurology, Hospital Universitario de León, Spain (J.T.); Stroke Unit, Department of Neurology, Hospital Universitari la Fe, Valencia, Spain (A.L.); and Department of Neurology, Hospital Universitari General Yagüe, Burgos, Spain (Y.B.).
authors.forename: Francisco
authors.initials: F
authors.lastname: Moniche
authors.affiliation: From the Stroke Unit, Department of Neurology (J.M., M.R.), Neurovascular Research Laboratory, Institut de Recerca-Universitat Autónoma de Barcelona (J.M., A.B., N.C., D.G., P.D.), and Vall d' Hebron Institut d'Oncologia (S.G.-M.), Hospital Universitari Vall d'Hebron, Barcelona, Spain; Neurovascular Unit, Department of Neurology, Hospital Universitario Donostia, Donostia-San Sebastian, Spain (M.M.-Z., A.A.); Department of Neurology, Hospital Universitari Son Espases, Palma de Mallorca, Spain (C.J., B.V.-P.); Stroke Program, Institute of Biomedicine of Seville, Hospital Universitario Virgen del Rocio, Seville, Spain (J.T., F.M.); Department of Neurology, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain (F.R.R.); Department of Neurology, Hospital Universitario Virgen de la Victoria, Albacete, Spain (T.S.); Stroke Unit, Department of Neurology, IRYCIS, University Hospital Ramón y Cajal, Madrid, Spain (J.M.); Department of Neurology, Hospital Universitari Parc Tauli, Sabadell, Spain (D.C.); Department of Neurology, Hospital de Basurto, Bilbao, Spain (M.F.); Department of Neurology, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain (R.D.-M.); Department of Neurology, Hospital Universitario de León, Spain (J.T.); Stroke Unit, Department of Neurology, Hospital Universitari la Fe, Valencia, Spain (A.L.); and Department of Neurology, Hospital Universitari General Yagüe, Burgos, Spain (Y.B.).
authors.forename: Pilar
authors.initials: P
authors.lastname: Delgado
authors.affiliation: From the Stroke Unit, Department of Neurology (J.M., M.R.), Neurovascular Research Laboratory, Institut de Recerca-Universitat Autónoma de Barcelona (J.M., A.B., N.C., D.G., P.D.), and Vall d' Hebron Institut d'Oncologia (S.G.-M.), Hospital Universitari Vall d'Hebron, Barcelona, Spain; Neurovascular Unit, Department of Neurology, Hospital Universitario Donostia, Donostia-San Sebastian, Spain (M.M.-Z., A.A.); Department of Neurology, Hospital Universitari Son Espases, Palma de Mallorca, Spain (C.J., B.V.-P.); Stroke Program, Institute of Biomedicine of Seville, Hospital Universitario Virgen del Rocio, Seville, Spain (J.T., F.M.); Department of Neurology, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain (F.R.R.); Department of Neurology, Hospital Universitario Virgen de la Victoria, Albacete, Spain (T.S.); Stroke Unit, Department of Neurology, IRYCIS, University Hospital Ramón y Cajal, Madrid, Spain (J.M.); Department of Neurology, Hospital Universitari Parc Tauli, Sabadell, Spain (D.C.); Department of Neurology, Hospital de Basurto, Bilbao, Spain (M.F.); Department of Neurology, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain (R.D.-M.); Department of Neurology, Hospital Universitario de León, Spain (J.T.); Stroke Unit, Department of Neurology, Hospital Universitari la Fe, Valencia, Spain (A.L.); and Department of Neurology, Hospital Universitari General Yagüe, Burgos, Spain (Y.B.).
authors.forename: Marc
authors.initials: M
authors.lastname: Ribó
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000188:drug therapy*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D019821:Simvastatin / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D020521:Stroke / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D005343:Fibrinolytic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019821:Simvastatin; D010959:Tissue Plasminogen Activator
keywords: clinical trial; neuroprotection; simvastatin; stroke; thrombolysis