title: Synergistic effect of anidulafungin combined with posaconazole in experimental aspergillosis.
abstract: Clinical and experimental data have shown discrepancies on the efficacy of combinations between triazoles and echinocandins. In this study, anidulafungin plus posaconazole have shown efficacy against a murine systemic infection by three strains of Aspergillus fumigatus. The combination increased mice survival and reduced burden in the kidneys over the corresponding monotherapies and voriconazole. Clearance of kidneys was observed in 62% to 100% of animals (strain dependant). We observed good in vitro- in vivo correlation when a cutoff < 1 was indicative of synergy. Our results showed that the combination could be a therapeutical option, especially against infections refractory to the first line therapy.
authors.forename: Adela
authors.initials: A
authors.lastname: Martin-Vicente
authors.forename: Javier
authors.initials: J
authors.lastname: Capilla
authors.forename: Josep
authors.initials: J
authors.lastname: Guarro
mesh_terms: D000077612:Anidulafungin; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001228:Aspergillosis / Q000188:drug therapy*; D001232:Aspergillus fumigatus / Q000187:drug effects* / Q000302:isolation & purification; D004195:Disease Models, Animal; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D054714:Echinocandins / Q000008:administration & dosage* / Q000494:pharmacology; D007668:Kidney / Q000382:microbiology; D008297:Male; D051379:Mice; D016019:Survival Analysis; D014230:Triazoles / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D014230:Triazoles; C101425:posaconazole; D000077612:Anidulafungin
keywords: A. fumigatus; anidulafungin; combined therapy; murine model; posaconazole