title: Adaptation inBacillus cereus: From Stress to Disease.
abstract: Bacillus cereusis a food-borne pathogen that causes diarrheal disease in humans. After ingestion,B. cereusexperiences in the human gastro-intestinal tract abiotic physical variables encountered in food, such as acidic pH in the stomach and changing oxygen conditions in the human intestine.B. cereusresponds to environmental changing conditions (stress) by reversibly adjusting its physiology to maximize resource utilization while maintaining structural and genetic integrity by repairing and minimizing damage to cellular infrastructure. As reviewed in this article,B. cereusadapts to acidic pH and changing oxygen conditions through diverse regulatory mechanisms and then exploits its metabolic flexibility to grow and produce enterotoxins. We then focus on the intricate link between metabolism, redox homeostasis, and enterotoxins, which are recognized as important contributors of food-borne disease.
authors.affiliation: Sécurité et Qualité des Produits d'Origine Végétale, UMR0408, Avignon Université, Institut National de la Recherche Agronomique Avignon, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Duport
authors.affiliation: Sécurité et Qualité des Produits d'Origine Végétale, UMR0408, Avignon Université, Institut National de la Recherche Agronomique Avignon, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Jobin
authors.affiliation: Sécurité et Qualité des Produits d'Origine Végétale, UMR0408, Avignon Université, Institut National de la Recherche Agronomique Avignon, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Schmitt
keywords: Bacillus cereus; acidic pH; metabolism; oxygen sensing; redox homeostasis