title: CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells.
authors.affiliation: Department of Anatomy and Embryology, Wuhan University School of Basic Medical Sciences, Wuhan, Hubei, P.R. China.|Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, MA, USA.|Department of Neurosurgery, Wuhan University Renmin Hospital, Wuhan, Hubei, P.R. China.
authors.forename: Haiwei
authors.initials: H
authors.lastname: Lian
authors.affiliation: Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, MA, USA.|Department of Medicine, Section of Hematology and Medical Oncology, Boston University School of Medicine, MA, USA.
authors.forename: Dun
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, MA, USA.|Department of Gynaecology, Wuhan University Renmin Hospital, Wuhan, Hubei, P.R. China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Medicine, Section of Hematology and Medical Oncology, Boston University School of Medicine, MA, USA.
authors.forename: Esther
authors.initials: E
authors.lastname: Landesman-Bollag
authors.affiliation: Department of Computer Science, Metropolitan College, Boston University, MA, USA.
authors.forename: Guanglan
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, MA, USA.
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Anderson
authors.affiliation: Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, MA, USA.
authors.forename: Kevin Charles
authors.initials: KC
authors.lastname: Tang
authors.affiliation: Department of Molecular, Cell and Cancer Biology, University of Massachusetts School of Medicine, Worcester, MA, USA.
authors.forename: Justine E
authors.initials: JE
authors.lastname: Roderick
authors.affiliation: Department of Molecular, Cell and Cancer Biology, University of Massachusetts School of Medicine, Worcester, MA, USA.
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Kelliher
authors.affiliation: Department of Medicine, Section of Hematology and Medical Oncology, Boston University School of Medicine, MA, USA.
authors.forename: David C
authors.initials: DC
authors.lastname: Seldin
authors.affiliation: Department of Anatomy and Embryology, Wuhan University School of Basic Medical Sciences, Wuhan, Hubei, P.R. China huifeng@bu.edu hueyfu@hotmail.com.
authors.forename: Hui
authors.initials: H
authors.lastname: Fu
authors.affiliation: Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, MA, USA huifeng@bu.edu hueyfu@hotmail.com.|Department of Medicine, Section of Hematology and Medical Oncology, Boston University School of Medicine, MA, USA.
authors.forename: Hui
authors.initials: H
authors.lastname: Feng
mesh_terms: D001381:Azepines / Q000819:agonists / Q000494:pharmacology*; D047390:Casein Kinase II / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D045744:Cell Line, Tumor; D004357:Drug Synergism; D005260:Female; D006801:Humans; D008297:Male; D009287:Naphthyridines / Q000819:agonists / Q000494:pharmacology*; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism*; D010619:Phenazines; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D055550:Protein Stability; D051881:Receptor, Notch1 / Q000235:genetics / Q000276:immunology*; D014230:Triazoles / Q000819:agonists / Q000494:pharmacology*
chemical_list: C561695:(+)-JQ1 compound; D001381:Azepines; C497761:NOTCH1 protein, human; D009287:Naphthyridines; D009363:Neoplasm Proteins; D010619:Phenazines; D051881:Receptor, Notch1; D014230:Triazoles; C555142:silmitasertib; D047390:Casein Kinase II