title: Long term disease free survival with multimodal therapy in small cell bladder cancer.
abstract: BACKGROUND
  Small cell bladder cancer (SCBC) is an aggressive subtype accounting for less than 1 % of all bladder malignancies associated with rapid progression, early metastases formation and high mortality rates.
  
  
  METHODS
  We present an unusual long term disease free survival of a 60 year-old man who was diagnosed with SCBC two and a half years ago. He underwent four cycles of cisplatin/etoposide chemotherapy as well as a prophylactic whole-brain radiotherapy followed by a radical cystoprostatectomy and ileal neobladder with extended pelvic lymphadenectomy. Since 33 months the patient is now recurrence-free.
  
  
  CONCLUSIONS
  In this case report, we were able to show that early multimodal therapy results in long term disease free survival, thus we highly recommend neoadjuvant chemotherapy as a part of multimodal management of a primary metastases-free, localized and surgically resectable SCBC.
authors.affiliation: Department of Urology, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria. isabel-maria.heidegger@i-med.ac.at.
authors.forename: Isabel
authors.initials: I
authors.lastname: Heidegger
authors.affiliation: Department of Urology, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
authors.forename: Gennadi
authors.initials: G
authors.lastname: Tulchiner
authors.affiliation: Division of General Pathology, Department of Pathology, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Georg
authors.initials: G
authors.lastname: Schäfer
authors.affiliation: Department of Urology, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Horninger
authors.affiliation: Department of Urology, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria. renate.pichler@i-med.ac.at.
authors.forename: Renate
authors.initials: R
authors.lastname: Pichler
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy*; D002945:Cisplatin / Q000627:therapeutic use; D003131:Combined Modality Therapy; D015653:Cystectomy; D018572:Disease-Free Survival; D005047:Etoposide / Q000627:therapeutic use; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D011468:Prostatectomy; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy*
chemical_list: D005047:Etoposide; D002945:Cisplatin
keywords: Disease free survival; Multimodal therapy; Neoadjuvant chemotherapy; Small cell bladder cancer