title: Recent Advances in Dynamic Kinetic Resolution by Chiral Bifunctional (Thio)urea- and Squaramide-Based Organocatalysts.
abstract: The organocatalysis-based dynamic kinetic resolution (DKR) process has proved to be a powerful strategy for the construction of chiral compounds. In this feature review, we summarized recent progress on the DKR process, which was promoted by chiral bifunctional (thio)urea and squaramide catalysis via hydrogen-bonding interactions between substrates and catalysts. A wide range of asymmetric reactions involving DKR, such as asymmetric alcoholysis of azlactones, asymmetric Michael-Michael cascade reaction, and enantioselective selenocyclization, are reviewed and demonstrate the efficiency of this strategy. The (thio)urea and squaramide catalysts with dual activation would be efficient for more unmet challenges in dynamic kinetic resolution.
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, China. lpan760615496@163.com.|College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei, China. lpan760615496@163.com.
authors.forename: Pan
authors.initials: P
authors.lastname: Li
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, China. xinquan@zjut.edu.cn.
authors.forename: Xinquan
authors.initials: X
authors.lastname: Hu
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei, China. xiuqindong@whu.edu.cn.
authors.forename: Xiu-Qin
authors.initials: XQ
authors.lastname: Dong
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei, China. xumu@whu.edu.cn.|Department of Chemistry, South University of Science and Technology of China, Shenzhen 518000, Guangdong, China. xumu@whu.edu.cn.
authors.forename: Xumu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D002384:Catalysis; D006860:Hydrogen Bonding; D007700:Kinetics; D015394:Molecular Structure; D011803:Quinine / Q000031:analogs & derivatives* / Q000737:chemistry; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry*
chemical_list: C000609819:squaramide; D011803:Quinine; D013890:Thiourea
keywords: (thio)urea; dynamic kinetic resolution; squaramide