title: Assessing the Comorbidity Gap between Clinical Studies and Prevalence in Elderly Patient Populations.
abstract: Well-designed and well-conducted clinical studies represent gold standard approaches for generating medical evidence. However, elderly populations are systematically underrepresented in studies across major chronic medical conditions, which has hampered the generalizability (external validity) of studies to the real-world patient population. It is the norm that intervention studies often require a homogeneous cohort to test their hypotheses; therefore older adults with co-medications and comorbidities are often excluded. The purpose of this study is to assess the gap between clinical studies on comorbidities and prevalence in elderly populations derived from the National Health and Nutrition Examination Survey (NHANES) and the Multiparameter Intelligent Monitoring in Intensive Care II (MIMIC-II) dataset. A comorbidity gap between them was observed and reported in this work.
authors.affiliation: School of Information and Institute for Successful Longevity at Florida State University, Tallahassee, FL 32308 USA (phone: 850-644-5775).
authors.forename: Zhe
authors.initials: Z
authors.lastname: He
authors.affiliation: Department of Psychology and Institute for Successful Longevity at Florida State University, Tallahassee, FL 32308 USA.
authors.forename: Neil
authors.initials: N
authors.lastname: Charness
authors.affiliation: Department of Health Outcomes and Policy, University of Florida, Gainesville, FL 32610 USA.
authors.forename: Jiang
authors.initials: J
authors.lastname: Bian
authors.affiliation: Department of Health Outcomes and Policy, University of Florida, Gainesville, FL 32610 USA.
authors.forename: William R
authors.initials: WR
authors.lastname: Hogan