title: Bronchial Artery Embolization in Hemoptysis: 10-Year Survival and Recurrence-Free Survival in Benign and Malignant Etiologies - A Retrospective Study.
abstract: Purpose:The aim of the study was to evaluate safety, effectiveness, recurrence rate and 10-year survival after bronchial artery embolization (BAE) in benign and malignant etiologies.Methods:The retrospective study includes 100 BAE procedures in 88 patients. Underlying disease was classified as benign (n = 67) and malignant (n = 21) etiologies. Immediate bleeding control and procedure safety were evaluated in all patients. In 51 (58 %) patients, follow-up data with a median follow-up time of 1015 days (range, 494 to 3727 days) were acquired to assess overall survival, time-to-recurrence of bleeding and recurrence-free survival, using Kaplan-Maier estimates to compare differences between both subgroups.Results:Immediate bleeding control was achieved after 96/100 procedures (96 %), with a minor complication rate of 5.0 %. No major complications occurred. The overall survival was 74 % after 1 year and 59 % after 5 years and 10 years. There was a significant difference in survival between the malignant and benign groups (p < 0.0001). Survival was 90 %, 80 % and 76 % at 1 year, 3 years and 10 years, respectively, in the benign group and 18 % and 0 % at 1 year and 3 years, respectively in the malignant group. The median time to recurrence of bleeding and recurrence-free survival were 239 days and 94 % after 1 year and 87 % after 10 years in the benign group, compared to 66 days and 34 % after 1 year and 0 % after 3 years in the malignant group (p = 0.0107).Conclusion:BAE is a safe and highly effective treatment option in hemoptysis. However, the recurrence rate and survival are highly dependent on the underlying disease.Key Points:• BAE is a safe and highly effective treatment option in hemoptysis.• Recurrence rate and survival are strongly dependent on the underlying disease with significantly impaired results in patients with malignant diseases. • Coil embolization is an effective BAE treatment method. Nevertheless, it should be mentioned, that reinterventions can be impeded, if embolization is performed in the proximal part of bronchial arteries.Citation Format:• Syha R, Benz T, Hetzel J et al. Bronchial Artery Embolization in Hemoptysis: 10-Year Survival and Recurrence-Free Survival in Benign and Malignant Etiologies - A Retrospective Study. Fortschr Röntgenstr 2016; 188: 1061 - 1066.
authors.affiliation: Diagnostic and Interventional Radiology, University Hospital Tuebingen, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Syha
authors.affiliation: Diagnostic and Interventional Radiology, University Hospital Tuebingen, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Benz
authors.affiliation: Internal Medicine II, Department of Oncology, Haematology, Clinical Immunology, Rheumatology and Pneumology, University of Tuebingen, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Hetzel
authors.affiliation: Internal Medicine II, Department of Oncology, Haematology, Clinical Immunology, Rheumatology and Pneumology, University of Tuebingen, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Spengler
authors.affiliation: Center for Pulmonology and Thoracic Surgery, Division of Pulmonology, Klinik Schillerhoehe, Gerlingen, Germany.
authors.forename: M J
authors.initials: MJ
authors.lastname: Kohlhäufl
authors.affiliation: Diagnostic and Interventional Radiology, University Hospital Tuebingen, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Gatidis
authors.affiliation: Diagnostic and Interventional Radiology, University Hospital Tuebingen, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Grözinger
authors.affiliation: Diagnostic and Interventional Radiology, University Hospital Tuebingen, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Horger
authors.affiliation: Diagnostic and Interventional Radiology, University Hospital Tuebingen, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Nikolaou
authors.affiliation: Diagnostic and Interventional Radiology, University Hospital Tuebingen, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Ketelsen
mesh_terms: D000328:Adult; D000368:Aged; D001916:Brachial Artery; D018572:Disease-Free Survival; D004621:Embolization, Therapeutic / Q000379:methods* / Q000401:mortality*; D005858:Germany / Q000453:epidemiology; D006469:Hemoptysis / Q000401:mortality* / Q000628:therapy*; D006490:Hemostatics / Q000627:therapeutic use; D006801:Humans; D008137:Longitudinal Studies; D008175:Lung Neoplasms / Q000401:mortality* / Q000628:therapy; D008875:Middle Aged; D015995:Prevalence; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D006490:Hemostatics