title: The Human Serotonin Type 3 Receptor Gene (HTR3A-E) Allelic Variant Database.
abstract: Serotonin type 3 (5-HT3) receptors are ligand-gated ion channels formed by five subunits (5-HT3A-E), which are encoded by the HTR3A, HTR3B, HTR3C, HTR3D, and HTR3E genes. Functional receptors are pentameric complexes of diverse composition. Different receptor subtypes confer a predisposition to nausea and vomiting during chemotherapy, pregnancy, and following surgery. In addition, different subtypes contribute to neurogastroenterologic disorders such irritable bowel syndrome (IBS) and eating disorders as well as comorbid psychiatric conditions. 5-HT3receptor antagonists are established treatments for emesis and IBS and are beneficial in the treatment of psychiatric diseases. Several case-control and pharmacogenetic studies have demonstrated an association between HTR3 variants and psychiatric and neurogastroenterologic phenotypes. Recently, their potential as predictors of nausea and vomiting and treatment of psychiatric disorders became evident. This information is now available in the serotonin receptor 3 HTR3 gene allelic variant database (www.htr3.uni-hd.de), which contains five sub-databases, one for each of the five different serotonin receptor genes HTR3A-E. Information on HTR3 variants, their functional relevance, associated phenotypes, and pharmacogenetic data such as drug response and side effects are available. This central information pool should help clinicians as well as scientists to evaluate their findings and to use the relevant information for subsequent genotype-phenotype correlation studies and pharmacogenetic approaches.
authors.affiliation: Center of Human and Clinical Genetics, Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
authors.forename: Jacopo
authors.initials: J
authors.lastname: Celli
authors.affiliation: Department of Human Molecular Genetics, University of Heidelberg, Heidelberg, Germany.
authors.forename: Gudrun
authors.initials: G
authors.lastname: Rappold
authors.affiliation: Department of Human Molecular Genetics, University of Heidelberg, Heidelberg, Germany.
authors.forename: Beate
authors.initials: B
authors.lastname: Niesler
mesh_terms: D000483:Alleles; D019295:Computational Biology / Q000379:methods; D030561:Databases, Nucleic Acid; D005767:Gastrointestinal Diseases / Q000188:drug therapy / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy / Q000235:genetics; D010597:Pharmacogenetics / Q000379:methods; D044406:Receptors, Serotonin, 5-HT3 / Q000235:genetics*; D057386:Search Engine; D058827:Serotonin 5-HT3 Receptor Agonists / Q000494:pharmacology / Q000627:therapeutic use; D058831:Serotonin 5-HT3 Receptor Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D016896:Treatment Outcome; D014584:User-Computer Interface
chemical_list: C509409:HTR3A protein, human; D044406:Receptors, Serotonin, 5-HT3; D058827:Serotonin 5-HT3 Receptor Agonists; D058831:Serotonin 5-HT3 Receptor Antagonists
keywords: complex disorder; neurogastroenterology; pharmacogenetics; psychiatry; serotonin; serotonin type 3 receptor; variant database