title: Soluble fibrinogen like protein 2 (sFGL2), the novel effector molecule for immunoregulation.
abstract: Soluble fibrinogen-like protein 2 (sFGL2) is the soluble form of fibrinogen-like protein 2 belonging to the fibrinogen-related protein superfamily. It is now well characterized that sFGL2 is mainly secreted by regulatory T cell (Treg) populations, and exerts potently immunosuppressive activities. By repressing not only the differentiation and proliferation of T cells but also the maturation of dendritic cells (DCs), sFGL2 acts largely as an immunosuppressant. Moreover, sFGL2 also induces apoptosis of B cells, tubular epithelial cells (TECs), sinusoidal endothelial cells (SECs), and hepatocytes. This mini-review focuses primarily on the recent literature with respect to the signaling mechanism of sFGL2 in immunomodulation, and discusses the clinical implications of sFGL2 in transplantation, hepatitis, autoimmunity, and tumors.
authors.affiliation: Department of Hematology, Qilu Hospital, Shandong University, Jinan, P. R. China.
authors.forename: Xin-Guang
authors.initials: XG
authors.lastname: Liu
authors.affiliation: School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology, Jinan, P. R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Hematology, Qilu Hospital, Shandong University, Jinan, P. R. China.|Capital Medical University Cancer Center, Beijing Shijitan Hospital, Beijing Key Laboratory for Therapeutic Cancer Vaccines, Beijing, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D015551:Autoimmunity; D004198:Disease Susceptibility; D005340:Fibrinogen / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D056747:Immunomodulation; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction
chemical_list: C095202:FGL2 protein, human; D005340:Fibrinogen
keywords: autoimmunity; hepatitis; immunoregulation; soluble fibrinogen-like protein 2; transplantation