title: Protective effect of sesquiterpene lactone parthenolide on LPS-induced acute lung injury.
abstract: Acute lung injury (ALI) is a respiratory failure disease and the major source of mortality in the critically ill patients. The main pathological changes involved in ALI include the excessive recruitment and activation of neutrophils by increased pro-inflammatory mediators. However, any specific therapy for ALI has not been developed. The objective of this study was to investigate protective effects of parthenolide, a sesquiterpene lactone produced in feverfew, on LPS-induced lung injury. In the present study, parthenolide treatment reduced infiltration of inflammatory cells, airway permeability and production of pro-inflammatory cytokines in LPS-induced ALI mouse model. Further, LPS-stimulated phosphorylation of NF-κB, the key regulatory transcription factor in ALI, was inhibited by parthenolide treatment in lung epithelial BEAS-2B cells and alveolar macrophage MH-S cells. These results suggest that parthenolide may provide a beneficial therapeutic strategy for ALI.
authors.affiliation: Department of Environmental and Health Chemistry, College of Pharmacy, Chung-Ang University, 84, Heukseok-ro, Dongjak-Ku, Seoul, 156-756, Republic of Korea.
authors.forename: You Jin
authors.initials: YJ
authors.lastname: Jang
authors.affiliation: Department of Environmental and Health Chemistry, College of Pharmacy, Chung-Ang University, 84, Heukseok-ro, Dongjak-Ku, Seoul, 156-756, Republic of Korea.
authors.forename: Moon Jung
authors.initials: MJ
authors.lastname: Back
authors.affiliation: Department of Environmental and Health Chemistry, College of Pharmacy, Chung-Ang University, 84, Heukseok-ro, Dongjak-Ku, Seoul, 156-756, Republic of Korea.
authors.forename: Zhicheng
authors.initials: Z
authors.lastname: Fu
authors.affiliation: Department of Environmental and Health Chemistry, College of Pharmacy, Chung-Ang University, 84, Heukseok-ro, Dongjak-Ku, Seoul, 156-756, Republic of Korea.
authors.forename: Joo Hyun
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Environmental and Health Chemistry, College of Pharmacy, Chung-Ang University, 84, Heukseok-ro, Dongjak-Ku, Seoul, 156-756, Republic of Korea.
authors.forename: Jong Hoon
authors.initials: JH
authors.lastname: Won
authors.affiliation: Department of Environmental and Health Chemistry, College of Pharmacy, Chung-Ang University, 84, Heukseok-ro, Dongjak-Ku, Seoul, 156-756, Republic of Korea.
authors.forename: Hae Chan
authors.initials: HC
authors.lastname: Ha
authors.affiliation: Department of Environmental and Health Chemistry, College of Pharmacy, Chung-Ang University, 84, Heukseok-ro, Dongjak-Ku, Seoul, 156-756, Republic of Korea.
authors.forename: Hae Kyung
authors.initials: HK
authors.lastname: Lee
authors.affiliation: Department of Environmental and Health Chemistry, College of Pharmacy, Chung-Ang University, 84, Heukseok-ro, Dongjak-Ku, Seoul, 156-756, Republic of Korea.
authors.forename: Ji Min
authors.initials: JM
authors.lastname: Jang
authors.affiliation: Department of Environmental and Health Chemistry, College of Pharmacy, Chung-Ang University, 84, Heukseok-ro, Dongjak-Ku, Seoul, 156-756, Republic of Korea.
authors.forename: Jong Min
authors.initials: JM
authors.lastname: Choi
authors.affiliation: Department of Environmental and Health Chemistry, College of Pharmacy, Chung-Ang University, 84, Heukseok-ro, Dongjak-Ku, Seoul, 156-756, Republic of Korea. kimdk@cau.ac.kr.
authors.forename: Dae Kyong
authors.initials: DK
authors.lastname: Kim
mesh_terms: D000072283:A549 Cells; D055371:Acute Lung Injury / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007783:Lactones / Q000494:pharmacology / Q000627:therapeutic use*; D008070:Lipopolysaccharides / Q000633:toxicity*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D012717:Sesquiterpenes / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007783:Lactones; D008070:Lipopolysaccharides; D020011:Protective Agents; D012717:Sesquiterpenes; C002669:parthenolide
keywords: Acute lung injury; LPS; Parthenolide