title: Circulating tumor cells in breast cancer: applications in personalized medicine.
abstract: Recent technological advancements in rare cell analysis have facilitated the detection of circulating tumor cells (CTCs) in the blood of patients diagnosed with breast and other types of cancers. Numerous clinical studies involving the enumeration of CTCs in breast cancer patients have unequivocally demonstrated the prognostic value of these cells. Evidence from recent molecular studies indicates that CTCs may be potential surrogate markers for systemic disease. As such, real-time assessment of therapeutic biomarkers in breast CTCs, such as the estrogen receptor (ER) and the human epidermal growth factor receptor 2 (HER2), may have a tremendous impact in guiding-targeted cancer therapy. In this review, we discuss the clinical implications of CTC detection and its potential utility for personalized medicine in breast cancer.
authors.affiliation: Division of Hematology/Oncology, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, 1600 Divisadero Street, San Francisco, CA, 94115, USA.
authors.forename: Jin Sun
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Division of Hematology/Oncology, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, 1600 Divisadero Street, San Francisco, CA, 94115, USA. mark.magbanua@ucsf.edu.
authors.forename: Mark Jesus M
authors.initials: MJM
authors.lastname: Magbanua
authors.affiliation: Division of Hematology/Oncology, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, 1600 Divisadero Street, San Francisco, CA, 94115, USA.
authors.forename: John W
authors.initials: JW
authors.lastname: Park
mesh_terms: D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D005260:Female; D023281:Genomics / Q000379:methods; D006801:Humans; D000073890:Liquid Biopsy / Q000379:methods; D025202:Molecular Diagnostic Techniques; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009360:Neoplastic Cells, Circulating / Q000378:metabolism* / Q000473:pathology*; D057285:Precision Medicine / Q000379:methods; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor
keywords: Breast cancer; Circulating tumor cells (CTCs); Estrogen receptor; HER2; Personalized medicine