title: DCE-MRI, DW-MRI, and MRS in Cancer: Challenges and Advantages of Implementing Qualitative and Quantitative Multi-parametric Imaging in the Clinic.
abstract: Multi-parametric magnetic resonance imaging (mpMRI) offers a unique insight into tumor biology by combining functional MRI techniques that inform on cellularity (diffusion-weighted MRI), vascular properties (dynamic contrast-enhanced MRI), and metabolites (magnetic resonance spectroscopy) and has scope to provide valuable information for prognostication and response assessment. Challenges in the application of mpMRI in the clinic include the technical considerations in acquiring good quality functional MRI data, development of robust techniques for analysis, and clinical interpretation of the results. This article summarizes the technical challenges in acquisition and analysis of multi-parametric MRI data before reviewing the key applications of multi-parametric MRI in clinical research and practice.
authors.affiliation: *MRI Unit, The Royal Marsden NHS Foundation Trust, Downs Road, Surrey †Cancer Research UK Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK.
authors.forename: Jessica M
authors.initials: JM
authors.lastname: Winfield
authors.forename: Geoffrey S
authors.initials: GS
authors.lastname: Payne
authors.forename: Alex
authors.initials: A
authors.lastname: Weller
authors.forename: Nandita M
authors.initials: NM
authors.lastname: deSouza
mesh_terms: D000554:Ambulatory Care Facilities / Q000639:trends; D038524:Diffusion Magnetic Resonance Imaging / Q000592:standards / Q000639:trends; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000639:trends; D008297:Male; D009369:Neoplasms / Q000000981:diagnostic imaging; D011467:Prostate / Q000473:pathology; D015203:Reproducibility of Results