title: From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on "New frontiers in cardiovascular research".
abstract: In this meeting report, particularly addressing the topic of protection of the cardiovascular system from ischemia/reperfusion injury, highlights are presented that relate to conditioning strategies of the heart with respect to molecular mechanisms and outcome in patients' cohorts, the influence of co-morbidities and medications, as well as the contribution of innate immune reactions in cardioprotection. Moreover, developmental or systems biology approaches bear great potential in systematically uncovering unexpected components involved in ischemia-reperfusion injury or heart regeneration. Based on the characterization of particular platelet integrins, mitochondrial redox-linked proteins, or lipid-diol compounds in cardiovascular diseases, their targeting by newly developed theranostics and technologies opens new avenues for diagnosis and therapy of myocardial infarction to improve the patients' outcome.
authors.affiliation: Institute of Biochemistry, Medical School, Justus-Liebig University, Giessen, Germany.|Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, 8 College Road, Singapore, 169857, Singapore.|National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore.|Department of Microbiology, Kazan Federal University, Kazan, Russian Federation.|Centro de Biotecnología-FEMSA, Tecnológico de Monterrey, Monterrey, NL, Mexico.
authors.forename: Hector A
authors.initials: HA
authors.lastname: Cabrera-Fuentes
authors.affiliation: Research Unit, Hospital of Santa Cristina, Research Institute Princesa, Autonomous University of Madrid, Madrid, Spain.
authors.forename: Julian
authors.initials: J
authors.lastname: Aragones
authors.affiliation: Department of Vascular Biology, Institute for Stroke and Dementia Research, Klinikum der Ludwig-Maximilians-Universität, Munich, Germany.|Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Bernhagen
authors.affiliation: Department of Cardiovascular Surgery, Medical School, Justus-Liebig-University, Giessen, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Boening
authors.affiliation: Department of Microbiology, Kazan Federal University, Kazan, Russian Federation.|Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, USA.
authors.forename: William A
authors.initials: WA
authors.lastname: Boisvert
authors.affiliation: Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus N, Denmark.
authors.forename: Hans E
authors.initials: HE
authors.lastname: Bøtker
authors.affiliation: Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, 8 College Road, Singapore, 169857, Singapore.|National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore.|The Hatter Cardiovascular Institute, University College London, London, UK.
authors.forename: Heerajnarain
authors.initials: H
authors.lastname: Bulluck
authors.affiliation: Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, 8 College Road, Singapore, 169857, Singapore.|National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore.
authors.forename: Stuart
authors.initials: S
authors.lastname: Cook
authors.affiliation: Department of Biomedical Sciences, University of Padova, Padua, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Di Lisa
authors.affiliation: Experimental Renal and Cardiovascular Research, Department of Nephropathology, Institute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Nuremberg, Germany.
authors.forename: Felix B
authors.initials: FB
authors.lastname: Engel
authors.affiliation: Institut für Laboratoriumsmedizin, Ludwig-Maximilians-Universität, Munich, Germany.
authors.forename: Bernd
authors.initials: B
authors.lastname: Engelmann
authors.affiliation: Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Nuremberg, Germany.
authors.forename: Fulvia
authors.initials: F
authors.lastname: Ferrazzi
authors.affiliation: Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary.|Pharmahungary Group, Szeged, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Ferdinandy
authors.affiliation: Department of Cardiology, Sarawak Heart Centre, Sarawak, Malaysia.
authors.forename: Alan
authors.initials: A
authors.lastname: Fong
authors.affiliation: Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe-University, Frankfurt, Germany.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Fleming
authors.affiliation: D. Swarovski Research Lab, Department of Visceral, Transplant Thoracic Surgery, Medical Univ Innsbruck, Innsbruck, Austria.
authors.forename: Erich
authors.initials: E
authors.lastname: Gnaiger
authors.affiliation: Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, 8 College Road, Singapore, 169857, Singapore.|National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore.|Department of Cardiovascular Medicine, National Institute of Cardiology, Ignacio Chavez, Mexico, D.F., Mexico.
authors.forename: Sauri
authors.initials: S
authors.lastname: Hernández-Reséndiz
authors.affiliation: The Hatter Cardiovascular Institute, University College London, London, UK.|The National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, UK.
authors.forename: Siavash Beikoghli
authors.initials: SB
authors.lastname: Kalkhoran
authors.affiliation: Department of Cardiology, Dong-A University Hospital, Busan, Korea.
authors.forename: Moo Hyun
authors.initials: MH
authors.lastname: Kim
authors.affiliation: Hatter Institute and MRC Inter-University Cape Heart Unit, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Lecour
authors.affiliation: Institute for Molecular Cardiovascular Research, RWTH University Hospital, Aachen, Germany.
authors.forename: Elisa A
authors.initials: EA
authors.lastname: Liehn
authors.affiliation: Department of Cardiology, The Rayne Institute, St Thomas' Campus, King's College London, London, UK.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Marber
authors.affiliation: The James Black Centre, King's College, University of London, London, UK.
authors.forename: Manuel
authors.initials: M
authors.lastname: Mayr
authors.affiliation: Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Miura
authors.affiliation: Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, 8 College Road, Singapore, 169857, Singapore.|National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore.
authors.forename: Sang-Bing
authors.initials: SB
authors.lastname: Ong
authors.affiliation: Baker IDI Heart and Diabetes Institute, Melbourne, Australia.
authors.forename: Karlheinz
authors.initials: K
authors.lastname: Peter
authors.affiliation: Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Sedding
authors.affiliation: Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, 8 College Road, Singapore, 169857, Singapore.|National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore.
authors.forename: Manvendra K
authors.initials: MK
authors.lastname: Singh
authors.affiliation: Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, UK.
authors.forename: M Saadeh
authors.initials: MS
authors.lastname: Suleiman
authors.affiliation: Institute of Anatomy and Vascular Biology, Westfalian-Wilhelms-University, Münster, Germany.
authors.forename: Hans J
authors.initials: HJ
authors.lastname: Schnittler
authors.affiliation: Institute of Physiology, Justus-Liebig University, Giessen, Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Schulz
authors.affiliation: National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore.
authors.forename: Winston
authors.initials: W
authors.lastname: Shim
authors.affiliation: Research Unit, Hospital of Santa Cristina, Research Institute Princesa, Autonomous University of Madrid, Madrid, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Tello
authors.affiliation: Department of Pathology, John A. Burns School of Medicine, University of Hawaii, Honolulu, USA.
authors.forename: Carl-Wilhelm
authors.initials: CW
authors.lastname: Vogel
authors.affiliation: The Hatter Cardiovascular Institute, University College London, London, UK.
authors.forename: Malcolm
authors.initials: M
authors.lastname: Walker
authors.affiliation: Research Unit, Hospital of Santa Cristina, Research Institute Princesa, Autonomous University of Madrid, Madrid, Spain.
authors.forename: Qilong Oscar Yang
authors.initials: QO
authors.lastname: Li
authors.affiliation: The Hatter Cardiovascular Institute, University College London, London, UK.|The National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, UK.
authors.forename: Derek M
authors.initials: DM
authors.lastname: Yellon
authors.affiliation: Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, 8 College Road, Singapore, 169857, Singapore. derek.hausenloy@duke-nus.edu.sg.|National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore. derek.hausenloy@duke-nus.edu.sg.|The Hatter Cardiovascular Institute, University College London, London, UK. derek.hausenloy@duke-nus.edu.sg.|The National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, UK. derek.hausenloy@duke-nus.edu.sg.
authors.forename: Derek J
authors.initials: DJ
authors.lastname: Hausenloy
authors.affiliation: Institute of Biochemistry, Medical School, Justus-Liebig University, Giessen, Germany.|Department of Microbiology, Kazan Federal University, Kazan, Russian Federation.
authors.forename: Klaus T
authors.initials: KT
authors.lastname: Preissner
mesh_terms: D000818:Animals; D002309:Cardiology / Q000379:methods / Q000639:trends*; D002318:Cardiovascular Diseases; D006801:Humans; D000068936:Theranostic Nanomedicine / Q000639:trends*
keywords: Cardiomyocyte signaling pathways; Cardioprotection; Cardiovascular disease; Co-morbidities; Drug targeting; Endothelial permeability; Extracellular RNA (eRNA); Heart regeneration; Induced pluripotent stem cells; Ischemia–reperfusion injury; Lipid metabolism; MicroRNAs (miRNAs); Mitochondria; Remote ischemic conditioning