title: Multiple sclerosis is accompanied by lack ofKIR2DS1gene: A meta-analysis.
abstract: Multiple sclerosis (MS) is a disease in which we can recognize destruction of the myelin that is around nerve cells of brain and spinal cord called as oligodendrocytes. Both genetic and environmental factors play roles in MS. One of these genes is thekiller-cell immunoglobulin-like receptor(KIR) which expressed on surface of natural killer cells (NKs). These genes have loci (not locus) in human genome, so they inherit as haplotypes. The results of previous studies show that different genes ofKIRmay affect both susceptibility and resistance to such autoimmune disorders that their pathogenesis in MS is still unclear. Since NKs play key roles in immune tolerance, we intend to perform a meta-analysis for the correlation ofKIRgenes and MS. We used the software comprehensive meta-analysis for data of totally 568 MS patients and 280 controls. Among the 14 genes ofKIRin the human genome, lack ofKIR2DS1is accompanied by MS. NoKIRgene found to be a risk factor for MS. Further studies on other molecules of NKs like CD94 and NKG2a is suggested.
authors.affiliation: Associate Professor, Department of Immunology, Lorestan University of Medical Sciences, Khorramabad, Iran.
authors.forename: Farhad
authors.initials: F
authors.lastname: Shahsavar
authors.affiliation: Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
authors.forename: Shaghayegh
authors.initials: S
authors.lastname: Mapar
authors.affiliation: Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
authors.forename: Seyyed Amir Yasin
authors.initials: SA
authors.lastname: Ahmadi
keywords: Killer cell immunoglobulin-like receptor; Meta-analysis; Multiple sclerosis