title: High serum oxytocin is associated with metabolic syndrome in older men - The MINOS study.
abstract: OBJECTIVE
  Oxytocin regulates food intake, carbohydrate and lipid metabolism, and urinary sodium excretion. We assessed the association between serum oxytocin levels and presence of metabolic syndrome (MetS) in older men.
  
  
  METHODS
  Cross-sectional study was performed in 540 volunteer men aged 50-85yrs from the MINOS cohort. Oxytocin was measured in fasting serum by radioimmunoassay (Oxytocin RIA, Phoenix Pharmaceuticals). MetS was diagnosed using the harmonized definition.
  
  
  RESULTS
  Serum oxytocin was higher in 166 men with MetS vs. controls (p<0.005). After adjustment for confounders including leptin, higher oxytocin was associated with higher odds of MetS (OR=1.38 per SD, 95%CI: 1.10-1.71, p<0.005). Men with serum oxytocin >0.74pg/mL (median) had higher odds of MetS vs. men with oxytocin ⩽0.74pg/mL (OR=2.06, 95%CI: 1.33-3.18, p<0.005). Higher oxytocin levels and low testosterone levels (total or free) were significantly associated with higher odds of MetS jointly and independently of each other. Men having oxytocin >0.74pg/mL and total testosterone <300ng/dL (<10.4nmol/L) had higher odds of MetS vs. men without these characteristics (OR=3.95, 95%CI: 1.65-9.46, p<0.005). Men having 25-hydroxycholecalciferol levels <30ng/mL and oxytocin >0.74pg/mL had higher odds of MetS vs. men without these characteristics (OR=2.86, 95%CI: 1.47-5.58, p<0.01). Men having oxytocin >0.74pg/mL and osteocalcin levels <14.6ng/mL (lowest quartile) had higher odds of MetS vs. men without these characteristics (OR=4.12, 95%CI: 2.07-8.20, p<0.001).
  
  
  CONCLUSIONS
  In older men, higher serum oxytocin levels are associated with higher odds of MetS regardless of potential confounders.
authors.affiliation: INSERM UMR 1033, University of Lyon, Hospices Civils de Lyon, Lyon, France. Electronic address: pawel.szulc@inserm.fr.
authors.forename: Pawel
authors.initials: P
authors.lastname: Szulc
authors.affiliation: CNRS, iBV UMR 7277, Université Nice Sophia Antipolis, Parc Valrose Nice, France; INSERM, iBV, U1091, Nice, France.
authors.forename: Ez Zoubir
authors.initials: EZ
authors.lastname: Amri
authors.affiliation: Department of Biochemistry and Molecular Biology, Laboratory of Medical Biology, Hospices Civils de Lyon, Lyon, France.
authors.forename: Annie
authors.initials: A
authors.lastname: Varennes
authors.affiliation: Nice University Hospital, Saint Roch Hospital, Department of Hormonology, Nice, France.
authors.forename: Patricia
authors.initials: P
authors.lastname: Panaia-Ferrari
authors.affiliation: Nice University Hospital, Cimiez Hospital, Department of Clinical Research, Nice, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Fontas
authors.affiliation: Dept. of Public Health, University of Lyon, Hospices Civils de Lyon, Lyon, France.
authors.forename: Joëlle
authors.initials: J
authors.lastname: Goudable
authors.affiliation: INSERM UMR 1033, University of Lyon, Hospices Civils de Lyon, Lyon, France.
authors.forename: Roland
authors.initials: R
authors.lastname: Chapurlat
authors.affiliation: Nice University Hospital, Pasteur Hospital, Department of Rheumatology, Nice, France; UMR E-4320 MATOs CEA/iBEB/SBTN, Université Nice Sophia Antipolis, Faculté de Médecine, Nice, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Breuil
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001823:Body Composition; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology; D008875:Middle Aged; D015675:Osteocalcin; D010121:Oxytocin / Q000097:blood*; D011446:Prospective Studies; D011795:Surveys and Questionnaires
chemical_list: D015675:Osteocalcin; D010121:Oxytocin
keywords: Abdominal obesity; Men; Metabolic syndrome; Oxytocin