title: Neurological deficit following stereotactic radiosurgery for trigeminal neuralgia.
abstract: We report a unique case of neurological deficit from late onset multiple sclerosis (MS), in a 65-year-old woman, after stereotactic radiosurgery (SRS) for trigeminal neuralgia (TN). At 3.5months post-SRS for TN, the patient developed ataxia and left leg paraesthesiae and brain MRI showed altered signal and enhancement in the vicinity of the right trigeminal root entry zone (REZ). The symptoms remitted following treatment with intravenous methylprednisolone, however, 10months post-SRS, the patient developed gait ataxia and left lower limb weakness. MRI showed persistent T2 changes at the REZ and multiple new non-enhancing white matter lesions in the cerebrum and spinal cord; and oligoclonal bands were present in the cerebrospinal fluid but not serum. A diagnosis of multiple sclerosis (MS) was made. This report raises the issue of whether the risk of radiation-induced toxicity is increased in patients with MS treated with SRS. We hypothesise that breakdown in the blood brain barrier secondary to the radiosurgery may have triggered a vigorous local inflammatory response.
authors.affiliation: RPA Institute of Academic Surgery and Department of Neurosurgery, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Kemp
authors.affiliation: RPA Institute of Academic Surgery and Department of Neurosurgery, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia.
authors.forename: R S
authors.initials: RS
authors.lastname: Allan
authors.affiliation: RPA Institute of Academic Surgery and Department of Neurosurgery, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia.
authors.forename: N
authors.initials: N
authors.lastname: Patanjali
authors.affiliation: RPA Institute of Academic Surgery and Department of Neurosurgery, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia; Brain and Mind Centre, University of Sydney, Camperdown, NSW 2050, Australia.
authors.forename: M H
authors.initials: MH
authors.lastname: Barnett
authors.affiliation: RPA Institute of Academic Surgery and Department of Neurosurgery, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia; Brain and Mind Centre, University of Sydney, Camperdown, NSW 2050, Australia. Electronic address: drjonker@centralneurosurgery.com.au.
authors.forename: B P
authors.initials: BP
authors.lastname: Jonker
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging / Q000532:radiotherapy; D010292:Paresthesia / Q000000981:diagnostic imaging* / Q000209:etiology; D011832:Radiation Injuries / Q000000981:diagnostic imaging* / Q000209:etiology; D016634:Radiosurgery / Q000009:adverse effects*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014277:Trigeminal Neuralgia / Q000000981:diagnostic imaging* / Q000532:radiotherapy*
keywords: MS; Multiple sclerosis; SRS; Stereotactic radiosurgery; TN; Trigeminal neuralgia