title: Investigation of the inflammatory biomarkers of metabolic syndrome in adolescents.
abstract: BACKGROUND
  Metabolic syndrome (MetS) is a chronic and multifactorial syndrome characterized by a low-grade chronic inflammation, and a major risk factor for type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). In our study, we aimed to investigate the serum levels of high sensitive C-reactive protein (hs-CRP), haptoglobin (Hp), α2-macroglobulin (α2-MG), platelet factor-4 (PF-4), fetuin-A, serum amyloid P (SAP) and α1-acid glycoprotein (AGP) in an adolescent population with MetS.
  
  
  METHODS
  This study was performed in 43 (18 males, 25 females) MetS adolescents between the ages of 13 and 17 years (14.70±1.15) and 43 lean controls were matched for age and sex. The serum levels of Hp, α2-MG, PF-4, fetuin-A, SAP and AGP were measured by using a multi-ELISA technique.
  
  
  RESULTS
  Serum Hp, fetuin-A (p<0.01) and PF-4, hs-CRP, SAP, AGP (p<0.001) values of the MetS subjects were significantly higher than those of the controls. No difference was found in serum α2-MG levels between the MetS and control groups (p=0.184).
  
  
  CONCLUSIONS
  This finding suggests the possibility of using these markers in diagnosis of MetS in adolescents to prevent future complications.
authors.forename: Ummugulsum
authors.initials: U
authors.lastname: Can
authors.forename: Muammer
authors.initials: M
authors.lastname: Buyukinan
authors.forename: Asuman
authors.initials: A
authors.lastname: Guzelant
authors.forename: Ayse
authors.initials: A
authors.lastname: Ugur
authors.forename: Adnan
authors.initials: A
authors.lastname: Karaibrahimoglu
authors.forename: Sukrıye
authors.initials: S
authors.lastname: Yabancıun
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006242:Haptoglobins / Q000032:analysis*; D006784:Hospitals, Teaching; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology / Q000276:immunology / Q000378:metabolism; D009961:Orosomucoid / Q000032:analysis*; D010044:Outpatient Clinics, Hospital; D010978:Platelet Factor 4 / Q000097:blood*; D012372:ROC Curve; D012306:Risk; D000683:Serum Amyloid P-Component / Q000032:analysis*; D014421:Turkey / Q000453:epidemiology; D015854:Up-Regulation; D060749:alpha-2-HS-Glycoprotein / Q000032:analysis*
chemical_list: C556354:AHSG protein, human; D015415:Biomarkers; C485359:HP protein, human; D006242:Haptoglobins; D009961:Orosomucoid; D000683:Serum Amyloid P-Component; D060749:alpha-2-HS-Glycoprotein; D010978:Platelet Factor 4; D002097:C-Reactive Protein