title: The role of serum and urinary carbohydrate antigen 19-9 in predicting renal injury associated with ureteral stone.
abstract: This study was designed to evaluate the role of urinary and serum carbohydrate antigen 19-9 (CA19-9) as a biomarker in the assessment of patients with ureteral stone. A total of 38 patients with ureteral stone and hydronephrosis who underwent transurethral lithotripsy (TUL) (Group A) and 24 age-matched healthy controls (Group B) were evaluated in this study. Urinary and serum CA19-9 concentrations were measured in group A patients before TUL as well as 4 and 8 weeks following the operation. Urinary and serum CA19-9 concentrations were also measured in group B participants. Median concentration of urinary and serum CA19-9 was 34.0 and 15.0 kU/L in group A patients and 16.1 and 5.3 kU/L in group B, respectively (p < 0.001). Medians of CA19-9 concentration in urine and serum reduced to 12.5 and 4.5 kU/L 8 weeks after TUL (p < 0.001). Following successful TUL and hydronephrosis resolution, a significant decline was detected in serum and urinary CA19-9. We also noted that duration of ureteral obstruction was associated with serum and urinary CA19-9 concentrations, suggesting the potential role of this marker in predicting renal damage associated with urinary tract obstruction and determining the appropriate timing of interventions.
authors.affiliation: a Uro-Oncology Research Center, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Erfan
authors.initials: E
authors.lastname: Amini
authors.affiliation: a Uro-Oncology Research Center, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Farhad
authors.initials: F
authors.lastname: Pishgar
authors.affiliation: b Pediatric Urology Research Center, Children's Hospital Medical Center, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Asal
authors.initials: A
authors.lastname: Hojjat
authors.affiliation: c Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences , Tehran , Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Soleimani
authors.affiliation: c Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences , Tehran , Iran.
authors.forename: Majid Ali
authors.initials: MA
authors.lastname: Asgari
authors.affiliation: b Pediatric Urology Research Center, Children's Hospital Medical Center, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Abdol-Mohammad
authors.initials: AM
authors.lastname: Kajbafzadeh
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000652:urine; D018395:CA-19-9 Antigen / Q000097:blood* / Q000652:urine*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006869:Hydronephrosis / Q000000981:diagnostic imaging / Q000628:therapy*; D007492:Iran; D007668:Kidney / Q000503:physiopathology; D008096:Lithotripsy; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed; D014514:Ureteral Calculi / Q000000981:diagnostic imaging / Q000628:therapy*; D014517:Ureteral Obstruction / Q000097:blood / Q000652:urine
chemical_list: D015415:Biomarkers; D018395:CA-19-9 Antigen
keywords: CA-19-9 antigen; hydronephrosis; lithotripsy; ureteral calculi; urolithiasis