title: The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis.
abstract: Most deaths from solid cancers occur as a result of secondary metastasis to distant sites. Bone is the most frequent metastatic site for many cancer types and can account for up to 80% of cancer-related deaths in certain tumours. The progression from a discrete solid primary tumour to devastating and painful bone metastases is a complex process involving multiple cell types and steps. There is increasing evidence that modulation of the extracellular matrix plays an important role in the lethal transition from a primary to disseminated metastatic bone tumour. This review provides an overview of the current understanding on the role of role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis.
authors.affiliation: Department of Oncology and Metabolism, The University of Sheffield, Sheffield S10 2RX, UK.
authors.forename: Alison
authors.initials: A
authors.lastname: Gartland
authors.affiliation: Biotech Research and Innovation Centre (BRIC), University of Copenhagen (UCPH), Ole Maaløes Vej 5, Copenhagen 2200, Denmark.
authors.forename: Janine T
authors.initials: JT
authors.lastname: Erler
authors.affiliation: Biotech Research and Innovation Centre (BRIC), University of Copenhagen (UCPH), Ole Maaløes Vej 5, Copenhagen 2200, Denmark.
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Cox