title: [Trends in Gleason scores of Chinese prostate carcinoma from 1995 to 2014].
abstract: To assess the changing trends in Gleason score (GS) of Chinese prostate carcinoma (PCa) from January 1995 to December 2014.
  
  
  
  In the study, 875 patients admitted to hospital from January 1995 to December 2004 (1995-2004) and from January 2005 to December 2014 (2005-2014) were divided into two groups. The mean levels and proportions of GS, primary and secondary grades were studied. The patients were divided into four groups according to age: <60, 60-69, 70-79 and ≥80 years. Types of specimen included needle biopsy (NB), transurethral resection of the prostate (TURP) and radical prostatectomy (RP). Histological types were made up by acinar carcinoma and other types (including atrophic, pseudohyperplastic, foam, signet ring cell and ductal carcinoma, and so on). The total prostate-specific antigen (tPSA) involved groups of <20.0 μg/L and ≥20.0 μg/L. We observed the mean levels and proportions of GS in age, types of specimen, histological types and total prostate-specific antigen in different periods, and used SPSS 17.0 software for statistical analysis.
  
  
  
  Compared with 1995-2004, the mean levels of GS, primary and secondary grades decreased 0.32 (P=0.003), 0.19 (P=0.001) and 0.12 (P=0.016) in 2005-2014, respectively. The proportions of ≤6 in GS increased 10.9% (P=0.003), and ≥8 decreased 14.0% (P<0.001). The difference of GS 7 was not statistically significant. In the primary grade, the ratio of grades≤3 increased 12.8% (P=0.001), and grade 4 decreased 7.4% (P=0.037), grade 5 decreased 5.5% (P=0.007). The ratio of secondary grades ≤3 increased 7.6% (P=0.037). The difference of grades 4 and 5 was not statistically significant.
  
  
  
  GS in Chinese patients with PCa showed a downward trend, which is one of the notable features in the past 20 years in China. The types of specimen and age are important factors in GS, while the histological types and tPSA have less impact on the GS.
authors.affiliation: Department of Pathology, Peking University People's Hospital, Beijing 100044, China.
authors.forename: G W
authors.initials: GW
authors.lastname: Wang
authors.affiliation: Department of Pathology, Peking University People's Hospital, Beijing 100044, China.
authors.forename: D H
authors.initials: DH
authors.lastname: Shen
authors.affiliation: Department of Urology, Peking University People's Hospital, Beijing 100044, China.
authors.forename: W Y
authors.initials: WY
authors.lastname: Zhang
authors.affiliation: Department of Urology, Peking University People's Hospital, Beijing 100044, China.
authors.forename: K X
authors.initials: KX
authors.lastname: Xu
authors.affiliation: Department of Urology, Peking University People's Hospital, Beijing 100044, China.
authors.forename: T
authors.initials: T
authors.lastname: Xu
authors.affiliation: Department of Urology, Peking University People's Hospital, Beijing 100044, China.
authors.forename: H
authors.initials: H
authors.lastname: Hu
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D001707:Biopsy, Needle; D002277:Carcinoma / Q000145:classification / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D002681:China; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading / Q000639:trends*; D011467:Prostate / Q000601:surgery; D017430:Prostate-Specific Antigen / Q000032:analysis; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000145:classification* / Q000453:epidemiology* / Q000473:pathology* / Q000601:surgery; D013995:Time; D020728:Transurethral Resection of Prostate
chemical_list: D017430:Prostate-Specific Antigen