title: Cochlearoids F-K: Phenolic meroterpenoids from the fungus Ganoderma cochlear and their renoprotective activity.
abstract: Ganoderma mushrooms are of great nutritious and medicinal values. This study was designed to characterize compounds from the fruiting bodies of Ganoderma cochlear and investigate their protective effects against kidney disorders. Six novel meroterpenoids cochlearoids F-K (1-6) were isolated by utilizing phytochemical approaches. Their structures were identified on the basis of extensive spectroscopic data and calculation methods. Biological evaluation shows that compounds 1-4 and 6 exhibit potent inhibitory activity on fibronectin overproduction in TGF-β1-induced HKC-8 cells.
authors.affiliation: Henan University of Chinese Medicine, Zhengzhou 450008, People's Republic of China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
authors.forename: Xin-Long
authors.initials: XL
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China.
authors.forename: Feng-Jiao
authors.initials: FJ
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
authors.forename: Man
authors.initials: M
authors.lastname: Dou
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
authors.forename: Yong-Ming
authors.initials: YM
authors.lastname: Yan
authors.affiliation: Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China.
authors.forename: Shu-Mei
authors.initials: SM
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China. Electronic address: dilei163@163.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Di
authors.affiliation: Henan University of Chinese Medicine, Zhengzhou 450008, People's Republic of China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China. Electronic address: yxcheng@mail.kib.ac.cn.
authors.forename: Yong-Xian
authors.initials: YX
authors.lastname: Cheng
mesh_terms: D002460:Cell Line; D005353:Fibronectins / Q000378:metabolism; D048690:Fruiting Bodies, Fungal / Q000737:chemistry*; D032902:Ganoderma / Q000737:chemistry*; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D020011:Protective Agents / Q000494:pharmacology*; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D053773:Transforming Growth Factor beta1 / Q000378:metabolism
chemical_list: D005353:Fibronectins; D020011:Protective Agents; D013729:Terpenes; D053773:Transforming Growth Factor beta1
keywords: (13)C NMR calculations; Ganoderma cochlear; Meroterpenoids; Renoprotection