title: The Association between LIPC rs493258 Polymorphism and the Susceptibility to Age-Related Macular Degeneration.
abstract: The purpose of this study was to evaluate the association of the hepatic lipase (LIPC) rs493258 polymorphism and susceptibility to age-related macular degeneration (AMD). A systematic search in PubMed, EMBASE, and ISI web of science databases was performed to identify eligible published studies without language restrictions up to April 2016. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) in different stages of AMD were estimated under different genetic models using meta-analytic methods. Seven studies comprising 20,559 cases and 17,200 controls met the inclusion criteria and were included in the meta-analysis. The LIPC rs493258 polymorphism showed a significant association with a lower risk of AMD under the allelic model (OR = 0.87, 95% CI = 0.84-0.90). Significant relationships between the variant and AMD were also observed in other genetic models (OR ranging from 0.71 to 0.86, allp< 0.05). Stratified analysis based on ethnicity found that LIPC rs493258 polymorphism had a significant association with the decreased risk of the disease in the Caucasian population, but not in the Asian population. For late AMD, significant associations of the rs493258 polymorphism with a lower risk of this disease were also observed in the allelic genetic model (OR = 0.87, 95% CI = 0.83-0.90). This meta-analysis demonstrates that the T allele in the LIPC rs493258 polymorphism was significantly associated with the risk of any and late AMD. The associations of the locus with early and late AMD risk in various populations need further exploration.
authors.affiliation: The First Affiliated Hospital of Xi'an Jiaotong University, College of Medicine, Xi'an Jiaotong University, Xi'an 710061, China. wyf.90.25.wyf@stu.xjtu.edu.cn.|Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China. wyf.90.25.wyf@stu.xjtu.edu.cn.|School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China. wyf.90.25.wyf@stu.xjtu.edu.cn.
authors.forename: Yafeng
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China. wangmx601@mail.xjtu.edu.cn.
authors.forename: Mingxu
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Public Health, Xi'an Medical University, Xi'an 710021, China. dyzhou@nwpu.edu.cn.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Humanities, Xi'an Jiaotong University, Xi'an 710049, China. boraisrighthere@sina.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Nie
authors.affiliation: Department of Internal Medicine, Xi'an Honghui Hospital, Xi'an 710054, China. male@mail.xjtu.edu.cn.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.affiliation: The First Affiliated Hospital of Xi'an Jiaotong University, College of Medicine, Xi'an Jiaotong University, Xi'an 710061, China. liuxiaoh@mail.xjtu.edu.cn.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Liu
authors.affiliation: School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China. xgcgfd@126.com.
authors.forename: Le
authors.initials: L
authors.lastname: Ma
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D008049:Lipase / Q000235:genetics*; D008268:Macular Degeneration / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D044465:White People / Q000235:genetics
chemical_list: C504173:LIPC protein, human; D008049:Lipase
keywords: LIPC; age-related macular degeneration; meta-analysis; polymorphism