title: Osseointegration of TI6Al4V dental implants modified by thermal oxidation in osteoporotic rabbits.
abstract: BACKGROUND
  In this work, the effect of the heat treatment on Ti6Al4V implants and topical administration of growth hormone to address a better osseointegration in osteoporotic patients has been analysed.
  
  
  METHODS
  The osseointegration process of Ti6Al4V implants modified by oxidation treatment at 700 °C for 1 h and the influence of local administration of growth hormone (GH) in osteoporotic female rabbits after 15 and 30 days of implantation have been studied. Bone response was analysed through densitometric and histomorphometric studies. Characterization of the surface was provided by scanning electron microscopy.
  
  
  RESULTS
  The oxidation treatment promotes the formation of an oxide scale grown on the Ti6Al4V implants that alters the nanoroughness of the surface. Bone mineral density (BMD) increases from 0.347 ± 0.014 (commercial) to 0.383 ± 0.012 g cm-2 (modified), and bone-to-implant contact (BIC) goes from 48.01 ± 14.78 (commercial) to 55.37 ± 15.31 (modified) after 30 days of implantation.
  
  
  CONCLUSIONS
  The oxidation treatment on the Ti6Al4V dental implants enhances the early bone formation at the longest periods of implantation. No significant differences in the BMD and BIC results in healthy and osteoporotic rabbits were revealed with respect to the local administration of GH in the implantation site.
authors.affiliation: Department of Characterization, Quality and Safety, Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), Madrid, Spain.
authors.forename: Oscar G
authors.initials: OG
authors.lastname: Bodelón
authors.affiliation: Department of Human Anatomy and Embryology, School of Medicine, University of Alcalá, Alcalá de Henares, Spain.
authors.forename: Celia
authors.initials: C
authors.lastname: Clemente
authors.affiliation: Stomatology Department IV, Complutense University of Madrid (UCM), Madrid, Spain.
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Alobera
authors.affiliation: Department of Human Anatomy and Embryology, School of Medicine, University of Alcalá, Alcalá de Henares, Spain.
authors.forename: Soledad
authors.initials: S
authors.lastname: Aguado-Henche
authors.affiliation: Department of Surface Engineering, Corrosion and Durability, National Center for Metallurgical Research (CENIM), CSIC, Avda. Gregorio del Amo 8, 28040, Madrid, Spain.
authors.forename: María Lorenza
authors.initials: ML
authors.lastname: Escudero
authors.affiliation: Department of Surface Engineering, Corrosion and Durability, National Center for Metallurgical Research (CENIM), CSIC, Avda. Gregorio del Amo 8, 28040, Madrid, Spain. crisga@cenim.csic.es.
authors.forename: María Cristina García
authors.initials: MC
authors.lastname: Alonso
keywords: Growth hormone; Histomorphometry; In vivo; Oxidation treatment; Ti6Al4V