title: Gynura procumbensExtract Alleviates Postprandial Hyperglycemia in Diabetic Mice.
abstract: This study was designed to investigate the inhibitory effect ofGynura procumbensextract against carbohydrate digesting enzymes and its ability to ameliorate postprandial hyperglycemia in streptozotocin (STZ)-induced diabetic mice.G. procumbensextract showed prominent α-glucosidase and α-amylase inhibitory effects. The half-maximal inhibitory concentration (IC50) ofG. procumbensextract against α-glucosidase and α-amylase was 0.092±0.018 and 0.084±0.027 mg/mL, respectively, suggesting that the α-amylase inhibition activity of theG. procumbensextract was more effective than that of the positive control, acarbose (IC50=0.164 mg/mL). The increase in postprandial blood glucose levels was more significantly alleviated in theG. procumbensextract group than in the control group of STZ-induced diabetic mice. Moreover, the area under the curve significantly decreased withG. procumbensextract administration in STZ-induced diabetic mice. These results suggest thatG. procumbensextract may help alleviate postprandial hyperglycemia by inhibiting carbohydrate digesting enzymes.
authors.affiliation: Department of Food Science and Nutrition, Pusan National University, Busan 46241, Korea.
authors.forename: Sung-In
authors.initials: SI
authors.lastname: Choi
authors.affiliation: Department of Food and Nutrition, College of Medical and Life Science, Silla University, Busan 46958, Korea.
authors.forename: Mi Hwa
authors.initials: MH
authors.lastname: Park
authors.affiliation: Department of Food Science and Nutrition, Pusan National University, Busan 46241, Korea.
authors.forename: Ji-Sook
authors.initials: JS
authors.lastname: Han
keywords: Gynura procumbens extract; postprandial hyperglycemia; α-amylase; α-glucosidase