title: Nonalcoholic Steatohepatitis.
abstract: Nonalcoholic steatohepatitis (NASH) has become a major cause of cirrhosis and liver-related deaths worldwide. NASH is strongly associated with obesity and the metabolic syndrome, conditions that cause lipid accumulation in hepatocytes (hepatic steatosis). It is not well understood why some, but not other, individuals with hepatic steatosis develop NASH. The factors that determine whether or not NASH progresses to cirrhosis are also unclear. This review summarizes key components of NASH pathogenesis and discusses how inherent and acquired variations in regulation of these processes impact the risk for NASH and NASH cirrhosis.
authors.affiliation: Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205.
authors.forename: Ayako
authors.initials: A
authors.lastname: Suzuki
authors.affiliation: Division of Gastroenterology, School of Medicine, Duke University, Durham, North Carolina 27710; email: annamae.diehl@duke.edu.
authors.forename: Anna Mae
authors.initials: AM
authors.lastname: Diehl
mesh_terms: D016923:Cell Death; D006505:Hepatitis / Q000209:etiology*; D022781:Hepatocytes / Q000473:pathology / Q000502:physiology; D006801:Humans; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008103:Liver Cirrhosis / Q000209:etiology*; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications / Q000378:metabolism* / Q000473:pathology*
keywords: adaptive mechanisms; hepatic fibrosis; hepatocyte damage; lipotoxicity; nonalcoholic fatty liver disease