title: Paclitaxel-Coated Balloons for the Treatment of Dysfunctional Dialysis Access. Results from a Single-Center, Retrospective Analysis.
abstract: OBJECTIVE
  To investigate the safety and effectiveness of lutonix paclitaxel-coated balloon (PCB) for the treatment of dysfunctional dialysis access.
  
  
  METHODS
  This was a single-center, single-arm, retrospective analysis of 39 patients (23 male, 59 %) undergoing 61 interventions using 69 PCBs in a 20-month period. There was a balance between arteriovenous fistulae (AVF) and grafts (AVG) (20 AVFs, 19AVGs), and the majority of lesions were restenotic (25/39, 64.1 %). Mean balloon diameter used was 6.6 mm and length 73.4 mm. Primary outcome measure was target lesion primary patency (TLPP) at 6 months, while secondary outcome measures included factors affecting TLPP and major complications. As there were lesions treated more than once with PCB, authors also compared patency results after first and second PCB angioplasty.
  
  
  RESULTS
  TLPP was 72.2 % at 6 months with a median patency of 260 days according to the Kaplan-Meier survival analysis. No major complications occurred. TLPP between AVFs and AVGs (311 vs. 237 days, respectively; p = 0.29) and de novo and restenotic lesions was similar (270.5 vs. 267.5 days, respectively; p = 0.50). In 14 cases, in which lesions were treated with two PCB angioplasties, a statistically significant difference in TLPP after the second treatment was noted (first intervention 179.5 days vs. second intervention 273.5 days; p = 0.032).
  
  
  CONCLUSIONS
  In this retrospective analysis, Lutonix PCB proved to be safe and effective in treating restenosis in dysfunctional dialysis access with results comparable to the literature available. Larger studies are needed to prove abovementioned results.
authors.affiliation: Interventional Radiology Department, Patras University Hospital, Patras, Greece. panoskitrou@gmail.com.
authors.forename: Panagiotis M
authors.initials: PM
authors.lastname: Kitrou
authors.affiliation: Interventional Radiology Department, Patras University Hospital, Patras, Greece.
authors.forename: Stavros
authors.initials: S
authors.lastname: Spiliopoulos
authors.affiliation: Interventional Radiology Department, Patras University Hospital, Patras, Greece.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Papadimatos
authors.affiliation: Interventional Radiology Department, Patras University Hospital, Patras, Greece.
authors.forename: Nicolaos
authors.initials: N
authors.lastname: Christeas
authors.affiliation: Interventional Radiology Department, Patras University Hospital, Patras, Greece.
authors.forename: Theodoros
authors.initials: T
authors.lastname: Petsas
authors.affiliation: Interventional Radiology Department, Patras University Hospital, Patras, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Katsanos
authors.affiliation: Interventional Radiology Department, Patras University Hospital, Patras, Greece.
authors.forename: Dimitris
authors.initials: D
authors.lastname: Karnabatidis
mesh_terms: D000800:Angioplasty, Balloon / Q000379:methods*; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D001164:Arteriovenous Fistula / Q000628:therapy*; D005260:Female; D006083:Graft Occlusion, Vascular / Q000628:therapy*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000627:therapeutic use*; D006435:Renal Dialysis; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D014654:Vascular Patency
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel
keywords: AVF; AVG; Angioplasty; Dialysis access; Fistula; Graft; Paclitaxel; Paclitaxel-coated balloon; Stenosis; Vascular access