title: Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma.
abstract: Radiotherapy performs an important function in the treatment of cancer, but resistance of tumor cells to radiation still remains a serious concern. More research on more effective radiosensitizers is urgently needed to overcome such resistance and thereby improve the treatment outcome. The goal of this study was to evaluate and compare the radiosensitizing efficacies of gold nanoparticles (AuNPs) and silver nanoparticles (AgNPs) on glioma at clinically relevant megavoltage energies. Both AuNPs and AgNPs potentiated the in vitro and in vivo antiglioma effects of radiation. AgNPs showed more powerful radiosensitizing ability than AuNPs at the same mass and molar concentrations, leading to a higher rate of apoptotic cell death. Furthermore, the combination of AgNPs with radiation significantly increased the levels of autophagy as compared with AuNPs plus radiation. These findings suggest the potential application of AgNPs as a highly effective nano-radiosensitizer for the treatment of glioma.
authors.affiliation: School of Medicine; State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University.
authors.forename: Peidang
authors.initials: P
authors.lastname: Liu
authors.affiliation: School of Medicine.
authors.forename: Haizhen
authors.initials: H
authors.lastname: Jin
authors.affiliation: The Second Affiliated Hospital of Nanjing Medical University.
authors.forename: Zhirui
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Traditional Chinese Medicine Hospital of Jiangsu Province, Nanjing, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.affiliation: School of Medicine.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.affiliation: School of Medicine.
authors.forename: Dongdong
authors.initials: D
authors.lastname: Li
authors.affiliation: State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University.
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University.
authors.forename: Ning
authors.initials: N
authors.lastname: Gu
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001343:Autophagy / Q000187:drug effects; D001932:Brain Neoplasms / Q000473:pathology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004195:Disease Models, Animal; D005260:Female; D005910:Glioma / Q000473:pathology*; D006046:Gold / Q000494:pharmacology*; D006801:Humans; D042541:Intracellular Space / Q000378:metabolism; D053208:Kaplan-Meier Estimate; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D012834:Silver / Q000494:pharmacology*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D011838:Radiation-Sensitizing Agents; D012834:Silver; D006046:Gold
keywords: apoptosis; autophagy; glioma; gold nanoparticles; radiosensitization; silver nanoparticles