title: Biomarkers of neuroendocrine tumors.
abstract: Neuroendocrine tumors (NET) are rare heterogenous tumors which prevalence is increasing. Their features vary by anatomical location, functionality and hormonal production. Their management needs a multidisciplinary approach. Functional tumors develop characteristic clinical syndromes in contrast to non-functional tumors that are diagnosed fortuitously or at advanced stage. NET can secrete many specific and general biomarkers. CgA is the most sensitive general marker. Its value should be interpreted along with the renal function and the gastrin level. Some new biomarkers such as NTproBNP, proGRP and NET gene transcripts have been identified. The latter are not yet routine in clinical practice. We present In this review biological biomarkers involved in NET with a focus on the assays and their use in clinical practice.
authors.affiliation: Faculté de médecine, Université de Lille, France, Centre de biologie-pathologie-génétique, Département de biochimie, CHRU de Lille, France.
authors.forename: Michèle
authors.initials: M
authors.lastname: d'Herbomez
authors.affiliation: Faculté de médecine, Université de Lille, France, Centre de biologie-pathologie-génétique, Département de biochimie, CHRU de Lille, France.
authors.forename: Lucie
authors.initials: L
authors.lastname: Coppin
authors.affiliation: Clinique d'endocrinologie, CHRU de Lille, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Bauters
authors.affiliation: Centre de biologie-pathologie-génétique, Département de biochimie, CHRU de Lille, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Rouaix-Emery
authors.affiliation: Faculté de médecine, Université de Lille, France, Service de chirurgie endocrinienne, CHRU de Lille, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Carnaille
authors.affiliation: Clinique d'endocrinologie, CHRU de Lille, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Do Cao
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis / Q000502:physiology; D003937:Diagnosis, Differential; D003940:Diagnostic Techniques, Endocrine / Q000592:standards; D006801:Humans; D007340:Insulinoma / Q000175:diagnosis; D018358:Neuroendocrine Tumors / Q000175:diagnosis*; D010190:Pancreatic Neoplasms / Q000175:diagnosis; D009384:Paraneoplastic Endocrine Syndromes / Q000175:diagnosis; D012015:Reference Standards
chemical_list: D014408:Biomarkers, Tumor
keywords: biomarkers; calcitonin; chromogranin A; gastrin; metanephrines; neuroendocrine tumors; peptides; progastrin; proinsulin; serotonin