title: Is Low Serum Vitamin D Associated with Early Dental Implant Failure? A Retrospective Evaluation on 1625 Implants Placed in 822 Patients.
abstract: Aim. To investigate whether there is a correlation between early dental implant failure and low serum levels of vitamin D.Methods. All patients treated with dental implants in a single centre, in the period 2003-2015, were considered for enrollment in this study. The main outcome was early implant failure. The influence of patient-related variables on implant survival was calculated using the Chi-square test.Results. 822 patients treated with 1625 implants were selected for this study; 27 early failures (3.2%) were recorded. There was no link between gender, age, smoking, history of periodontitis, and an increased incidence of early failures. Statistical analysis reported 9 early failures (2.2%) in patients with serum levels of vitamin D > 30 ng/mL, 16 early failures (3.9%) in patients with levels between 10 and 30 ng/mL, and 2 early failures (9.0%) in patients with levels <10 ng/mL. Although there was an increasing trend in the incidence of early implant failures with the worsening of vitamin D deficiency, the difference between these 3 groups was not statistically significant (P= 0.15).Conclusions. This study failed in proving an effective link between low serum levels of vitamin D and an increased risk of early implant failure. Further studies are needed to investigate this topic.
authors.affiliation: Department of Surgical and Morphological Science, Dental School, University of Insubria, 21100 Varese, Italy.
authors.forename: Francesco
authors.identifier: 0000-0001-5488-4268
authors.initials: F
authors.lastname: Mangano
authors.affiliation: Department of Health Sciences, University of Eastern Piedmont, 28100 Novara, Italy.
authors.forename: Carmen
authors.identifier: 0000-0002-1150-1906
authors.initials: C
authors.lastname: Mortellaro
authors.affiliation: Division of Endocrinology and Metabolism, Moriggia Pelascini Hospital, 22015 Gravedona ed Uniti, Italy.
authors.forename: Natale
authors.initials: N
authors.lastname: Mangano
authors.affiliation: Department of Dental Sciences, University Vita Salute San Raffaele, 20132 Milan, Italy.
authors.forename: Carlo
authors.identifier: 0000-0002-4419-4674
authors.initials: C
authors.lastname: Mangano
mesh_terms: D000328:Adult; D015921:Dental Implants; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000097:blood; D012189:Retrospective Studies; D014807:Vitamin D / Q000097:blood*
chemical_list: D015921:Dental Implants; D014807:Vitamin D