title: Oncometabolite Accumulation and Epithelial-to-Mesenchymal Transition: The Turn of Fumarate.
abstract: Mutations to the Krebs cycle enzyme fumarate hydratase in cancer cells leads to an accumulation of the oncometabolite fumarate. Sciacovelli et al. (2016) demonstrate an epigenetically dependent epithelial-to-mesenchymal transition mediated by modulation of the miR-200 cluster and TET demethylation in response to fumarate accumulation.
authors.affiliation: Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain.
authors.forename: Maxime
authors.initials: M
authors.lastname: Janin
authors.affiliation: Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Catalonia, Spain; Department of Physiological Sciences II, School of Medicine, University of Barcelona, 08036 Barcelona, Catalonia, Spain. Electronic address: mesteller@idibell.cat.
authors.forename: Manel
authors.initials: M
authors.lastname: Esteller
mesh_terms: D058750:Epithelial-Mesenchymal Transition / Q000235:genetics*; D005649:Fumarate Hydratase / Q000235:genetics; D005650:Fumarates; D006801:Humans; D008745:Methylation; D035683:MicroRNAs / Q000235:genetics*
chemical_list: D005650:Fumarates; D035683:MicroRNAs; D005649:Fumarate Hydratase