title: A Dual Anticancer Efficacy Molecule: A Selective Dark Cytotoxicity Photosensitizer.
abstract: Unlike traditional binary nanostructures that construct chemotherapy drugs and photodynamic therapy photosensitizers, we introduce a molecule with a chemo-photodynamic dual therapy function. A water-soluble aggregation-induced emission enhancement (AIEE) fluorogen, NV-12P, was designed and synthesized based on asymmetric 1,6-disubstituted naphthalene and can generate particular reactive oxygen species to undergo type I photodynamic therapy under irradiation. Furthermore, this compound can specifically localize in mitochondria and, after biological evaluation, can cause mitochondrial dysfunction and potent cytotoxicity to cancer cells but not normal cells. We conclude that this compound is a potential dual-toxic efficacy molecule because it exhibits selective dark cytotoxicity and efficient photodamage in cancer cells. Additionally, we also supported the optimal combinational treatment course for the best chemo-phototherapy efficacy.
authors.affiliation: Department of Chemical Engineering, National Chung Hsing University , Taichung 402, Taiwan.
authors.forename: Jyun-Wei
authors.initials: JW
authors.lastname: Chen
authors.affiliation: Graduate Institute of Biomedical Engineering, National Chung Hsing University , Taichung 402, Taiwan.
authors.forename: Cheng-Chung
authors.initials: CC
authors.lastname: Chang
mesh_terms: D006367:HeLa Cells; D006801:Humans; D008928:Mitochondria; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry*; D017382:Reactive Oxygen Species
chemical_list: D017319:Photosensitizing Agents; D017382:Reactive Oxygen Species
keywords: aggregation-induced emission enhancement; chemo-phototherapy; mitochondrial dysfunction; photosensitizers; reactive oxygen species