title: Transgenic Mouse Models of Tumor Virus Action.
abstract: Genetically engineered mice (GEMs) have provided valuable insights into the carcinogenic properties of various human tumor viruses, which, in aggregate, are etiologically associated with over 15% of all human cancers. This review provides an overview of seminal discoveries made through the use of GEM models for human DNA tumor viruses. Emphasis is placed on the discoveries made in the study of human papillomaviruses, Merkel cell carcinoma-associated polyomavirus, Epstein-Barr virus, and Kaposi's sarcoma-associated herpesvirus, because GEMs have contributed extensively to our understanding of how these DNA tumor viruses directly contribute to human cancers.
authors.affiliation: McArdle Laboratory for Cancer Research, Department of Oncology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin 53705; email: plambert@wisc.edu.
authors.forename: Paul F
authors.initials: PF
authors.lastname: Lambert
mesh_terms: D000818:Animals; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000472:pathogenicity; D019288:Herpesvirus 8, Human / Q000235:genetics* / Q000472:pathogenicity; D059965:Merkel cell polyomavirus / Q000235:genetics* / Q000472:pathogenicity; D051379:Mice; D008822:Mice, Transgenic; D023421:Models, Animal; D009369:Neoplasms / Q000821:virology*; D027383:Papillomaviridae / Q000235:genetics* / Q000472:pathogenicity
keywords: EBV; GEM; HPV; KSHV; MCPyV; cancer; in vivo; transgenic