title: Sialodochitis fibrinosa (kussmaul disease) report of 3 cases and literature review.
abstract: Sialodochitis fibrinosa is a rare disease which is characterized by recurring episodes of pain and swelling of the salivary glands due to the formation of mucofibrinous plugs. Analytic studies ascertain elevated levels of eosinophils and immunoglobulin E (IgE). Imaging studies such as magnetic resonance imaging (MRI) and sialography reveal dilation of the main salivary duct (duct ectasia). Treatment is initially supportive, consisting of compressive massages, and use of antihistamines and/or corticosteroids.
  
  
  
  In the following, 3 cases of sialodochitis fibrinosa are presented which were diagnosed in a third level hospital during the period of 2008 and 2016, as well as a literature review of all cases reported to our knowledge.
  
  
  
  Of the 41 cases found, including the 3 of this article, 66% were women with an average age of 45 years old. However, 75% of reported cases were of Japanese heritage. Involvement of the parotid glands was more frequent than the submandibular glands. In more than half of all cases treatment with compressive massages, antihistamines and/or corticosteroids was effective.
  
  
  
  Clinicians should consider sialodochitis fibrinosa as a diagnostic possibility when presented with cases of recurring parotid and submandibular gland tumescence.
authors.affiliation: Rheumatology Division Radiodiagnostic Division, Puerta de Hierro Hospital, Madrid Neurology Division, Lozano Blesa Hospital, Zaragoza, Spain Independence Polyclinic, Belize Haematology Division Allergology Division Anatomical Pathology Division, Puerta de Hierro Hospital, Madrid, Spain.
authors.forename: Bryan Josue
authors.initials: BJ
authors.lastname: Flores Robles
authors.forename: Beatriz
authors.initials: B
authors.lastname: Brea Álvarez
authors.forename: Abel Alejandro
authors.initials: AA
authors.lastname: Sanabria Sanchinel
authors.forename: Robert Francis
authors.initials: RF
authors.lastname: Andrus
authors.forename: María
authors.initials: M
authors.lastname: Espinosa Malpartida
authors.forename: Consuelo
authors.initials: C
authors.lastname: Ramos Giráldez
authors.forename: Ana
authors.initials: A
authors.lastname: Lerma Verdejo
authors.forename: Carolina
authors.initials: C
authors.lastname: Merino Argumanez
authors.forename: Jose Antonio
authors.initials: JA
authors.lastname: Pérez Pimiento
authors.forename: Camen
authors.initials: C
authors.lastname: Bellas Menéndez
authors.forename: Luis Fernando
authors.initials: LF
authors.lastname: Villa Alcázar
authors.forename: José Luis
authors.initials: JL
authors.lastname: Andréu Sánchez
authors.forename: Mercedes
authors.initials: M
authors.lastname: Jiménez Palop
authors.forename: Hildegarda
authors.initials: H
authors.lastname: Godoy Tundidor
authors.forename: José
authors.initials: J
authors.lastname: Campos Esteban
authors.forename: Jesús
authors.initials: J
authors.lastname: Sanz Sanz
authors.forename: Carmen
authors.initials: C
authors.lastname: Barbadillo Mateos
authors.forename: Carlos María
authors.initials: CM
authors.lastname: Isasi Zaragoza
authors.forename: Juan Bartolomé
authors.initials: JB
authors.lastname: Mulero Mendoza
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D005355:Fibrosis / Q000175:diagnosis; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D012008:Recurrence; D012796:Sialography; D013363:Submandibular Gland / Q000000981:diagnostic imaging*; D013364:Submandibular Gland Diseases / Q000175:diagnosis*