title: Developing miRNA therapeutics for cardiac repair in ischemic heart disease.
abstract: MicroRNAs (miRNAs) families have been found to be powerful regulators in a wide variety of diseases, which enables the possible use of miRNAs in therapeutic strategies for cardiac repair after ischemic heart disease. This review provides some general insights into miRNAs modulation for development of current molecular and cellular therapeutics in cardiac repair, including endogenous regeneration, endogenous repair, stem cells transplantation, and reprogramming. We also review the delivery strategies for miRNAs modulation, and briefly summarize the current bench and clinical efforts that are being made to explore miRNAs as the future therapeutic target.
authors.affiliation: Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China;; Shanghai Institute of Cardiovascular Disease, Shanghai 200032, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Zhu
authors.affiliation: Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China;; Shanghai Institute of Cardiovascular Disease, Shanghai 200032, China.
authors.forename: Dingqian
authors.initials: D
authors.lastname: Liu
authors.affiliation: Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China;; Shanghai Institute of Cardiovascular Disease, Shanghai 200032, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Lai
authors.affiliation: Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China;; Shanghai Institute of Cardiovascular Disease, Shanghai 200032, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China;; Shanghai Institute of Cardiovascular Disease, Shanghai 200032, China.
authors.forename: Chunsheng
authors.initials: C
authors.lastname: Wang
keywords: MicroRNAs (miRNAs); cardiac repair; modulation; regeneration; stem cells