title: Prevotella and Klebsiella proportions in fecal microbial communities are potential characteristic parameters for patients with major depressive disorder.
abstract: The diagnosis of major depression disorder (MDD) and other mental disorders were depended on some subjective survey scales. There are confirmed relationship between the gut flora and the mental states of MDD patients.
  
  
  
  The V3-V4 region of the 16S rRNA gene was extracted from the fecal microbial communities in MDD patients, PCR amplified and sequenced on the Illumina Miseq platform.
  
  
  
  More phylum Firmicutes, less Bacteroidetes, and more genus Prevotella, Klebsiella, Streptococcus and Clostridium XI were found in MDD patients. The changes of the proportion of Prevotella and Klebsiella were consistent with Hamilton depression rating scale.
  
  
  
  The conclusion was limited by small sample sizes and potential uncontrollable influence factors on fecal microbiota.
  
  
  
  Prevotella and Klebsiella proportion in fecal microbial communities should be concerned in the diagnosis and therapeutic monitoring of MDD in future.
authors.affiliation: Department of Medical Laboratory, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Lin
authors.affiliation: Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
authors.forename: Bingyu
authors.initials: B
authors.lastname: Ding
authors.affiliation: Department of internal medicine, Zhejiang Medical College, Hangzhou 310053, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Feng
authors.affiliation: Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
authors.forename: Shuwei
authors.initials: S
authors.lastname: Yin
authors.affiliation: Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Qi
authors.affiliation: Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
authors.forename: Huiying
authors.initials: H
authors.lastname: Lv
authors.affiliation: Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
authors.forename: Xiaokui
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Dong
authors.affiliation: Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
authors.forename: Yongzhang
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address: qingtianli@gmail.com.
authors.forename: Qingtian
authors.initials: Q
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D001483:Base Sequence; D002681:China; D003865:Major Depressive Disorder / Q000235:genetics* / Q000382:microbiology; D005243:Feces / Q000382:microbiology*; D005260:Female; D041981:Gastrointestinal Tract; D006801:Humans; D007709:Klebsiella / Q000235:genetics / Q000302:isolation & purification*; D064307:Microbiota / Q000502:physiology*; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D018720:Prevotella / Q000235:genetics / Q000302:isolation & purification*; D012336:RNA, Ribosomal, 16S / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction; D055815:Young Adult
chemical_list: D012336:RNA, Ribosomal, 16S
keywords: Fecal microbial communities; Klebsiella; Major depressive disorder; Prevotella