title: Study of twenty preparations of human albumin solution which failed in quality control testing due to elevated sodium content, a poor internal quality control at manufacturing unit.
abstract: Current study is conducted in our laboratory due to failure in quality control testing of twenty batches of Human Albumin solution in which sodium content is higher than the prescribed limit. These batches are received in short duration from indigenous manufacturer and is the first incident of failure of Human albumin preparation in sodium content of manufacturer. On request of manufacturer, study is conducted to rule out the cause. Repeat testing of each out of specification batch is conducted and a trend analysis is drawn between our findings and manufacturer's results, also study of trend analysis of manufacturer for the last one year. Trend analysis data indicated towards poor consistency of batches with major shift at various time intervals in sodium content of human albumin preparation. Further analysis rule out that non-traceable quality of standard used in the internal quality control testing by manufacturer is the root cause of the problem.
authors.affiliation: National Institute of Biologicals, Uttar Pradesh, India.
authors.forename: J P
authors.initials: JP
authors.lastname: Prasad
authors.affiliation: National Institute of Biologicals, Uttar Pradesh, India.
authors.forename: Y
authors.initials: Y
authors.lastname: Madhu
authors.affiliation: National Institute of Biologicals, Uttar Pradesh, India.
authors.forename: Surinder
authors.initials: S
authors.lastname: Singh
authors.affiliation: National Institute of Biologicals, Uttar Pradesh, India.
authors.forename: G R
authors.initials: GR
authors.lastname: Soni
authors.affiliation: National Institute of Biologicals, Uttar Pradesh, India.
authors.forename: N
authors.initials: N
authors.lastname: Agnihotri
authors.affiliation: National Institute of Biologicals, Uttar Pradesh, India.
authors.forename: Varsha
authors.initials: V
authors.lastname: Singh
authors.affiliation: National Institute of Biologicals, Uttar Pradesh, India.
authors.forename: Pradeep
authors.initials: P
authors.lastname: Kumar
authors.affiliation: National Institute of Biologicals, Uttar Pradesh, India.
authors.forename: Nidhi
authors.initials: N
authors.lastname: Jain
authors.affiliation: National Institute of Biologicals, Uttar Pradesh, India.
authors.forename: Anu
authors.initials: A
authors.lastname: Prakash
authors.affiliation: National Institute of Biologicals, Uttar Pradesh, India. Electronic address: varunsinghbiochem@yahoo.co.in.
authors.forename: Varun
authors.initials: V
authors.lastname: Singh
mesh_terms: D000418:Albumins / Q000737:chemistry* / Q000592:standards; D006801:Humans; D011786:Quality Control; D012964:Sodium / Q000032:analysis*; D012996:Solutions
chemical_list: D000418:Albumins; D012996:Solutions; D012964:Sodium
keywords: Human albumin solution; Quality control; Sodium; Trend analysis