title: Value of multi-b value DWI in the assessment of early cerebral changes in asymptomatic HIV-positive adolescents.
abstract: Background Magnetic resonance imaging (MRI) and functional MRI techniques have been widely used in the diagnosis of human immunodeficiency virus (HIV) infection related diseases. Purpose To explore whether magnetic resonance diffusion-weighted imaging (DWI) can track water molecular diffusion changes in the brain of asymptomatic HIV-positive adolescents. Material and Methods Multi-b value DWI was performed in 23 adolescents, including 15 HIV-positive participants and eight HIV-negative healthy participants. Mean apparent diffusion coefficient (ADC), slow apparent diffusion coefficient (ADCs) values, fast apparent diffusion coefficient (ADCf) values, distribution diffusion coefficient (DDC) values, and heterogeneity index (α) values were calculated within regions of interest (ROIs) in the frontal lobes, basal ganglia, and temporal lobe. Non-parametric tests were then performed. Results In the bilateral frontal lobes, the mean α values in HIV-positive participants were significantly increased compared with those in healthy participants (right side P = 0.001; left side P = 0.000). In the left frontal lobe, the mean DDC value in HIV-positive participants was significantly increased compared with that in healthy participants ( P = 0.008). In the bilateral frontal lobes, the mean ADCf values in HIV-positive participants were significantly lower than those in healthy participants (right side P = 0.011; left side P = 0.008). In the left basal ganglia, the mean α values in HIV-positive participants were significantly lower than that in healthy participants ( P = 0.013). Conclusion Multi-b value DWI could reflect the early characteristics of water molecule diffusion in HIV infections.
authors.affiliation: 1 Key Laboratory of Artificial Micro- & Nano-structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan, PR China.
authors.forename: Da-Zhen
authors.initials: DZ
authors.lastname: Jiang
authors.affiliation: 1 Key Laboratory of Artificial Micro- & Nano-structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan, PR China.
authors.forename: Ding-Yi
authors.initials: DY
authors.lastname: Zhou
authors.affiliation: 1 Key Laboratory of Artificial Micro- & Nano-structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan, PR China.
authors.forename: Wei-Qing
authors.initials: WQ
authors.lastname: Wu
authors.affiliation: 2 Medical Imaging department of the Zhongnan Hospital of Wuhan University, Wuhan, PR China.
authors.forename: Guang-Yao
authors.initials: GY
authors.lastname: Wu
authors.affiliation: 1 Key Laboratory of Artificial Micro- & Nano-structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan, PR China.
authors.forename: Hong
authors.initials: H
authors.lastname: Quan
mesh_terms: D000293:Adolescent; D001834:Body Water / Q000000981:diagnostic imaging; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006679:HIV Seropositivity; D006801:Humans; D008297:Male
keywords: Asymptomatic HIV-positive; brain images; central nervous system; early cerebral changes; multi-b value diffusion-weighted imaging (DWI)