title: Cumulative radiation exposure from imaging procedures and associated lifetime cancer risk for patients with lymphoma.
abstract: The aim of this study was to systematically evaluate the cumulative radiation exposure and the associated lifetime-cancer-risk from diagnostic imaging in patients with Hodgkin-lymphoma-(HL) or diffuse-large-B-cell-lymphoma (DLBCL). 99 consecutive patients (53-males) diagnosed with HL or DLBCL were included in the study and followed. Based on the imaging reports, organ and effective-doses-(ED) were calculated individually for each patient and the excess lifetime risks were estimated. The average ED in the first year after diagnosis was significantly different for men (59 ± 33 mSv) and women (74 ± 33 mSv)-(p < 0.05). The mean cumulative ED in each of the following 5 years was 16 ± 16 mSv without significant differences between men and women-(p > 0.05). Over all years, more than 90% of the ED resulted from CT. The average cumulative radiation risk estimated for the first year was significantly lower for men (0.76 ± 0.41%) as compared to women (1.28 ± 0.54%)-(p < 0.05). The same was found for each of the subsequent 5-years (men-0.18 ± 0.17%; women-0.28 ± 0.25%)-(p < 0.05). In conclusion, for HL and DLBCL patients investigated in this study, a cumulative radiation risk of about 1 excess cancer per 100 patients is estimated for diagnostic imaging procedures performed during both the first year after diagnosis and a follow-up period of 5 years.
authors.affiliation: Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
authors.forename: Grete
authors.initials: G
authors.lastname: Fabritius
authors.affiliation: Federal Office for Radiation Protection, Department of Medical Radiation Protection, Neuherberg, Germany.
authors.forename: Gunnar
authors.initials: G
authors.lastname: Brix
authors.affiliation: Federal Office for Radiation Protection, Department of Medical Radiation Protection, Neuherberg, Germany.
authors.forename: Elke
authors.initials: E
authors.lastname: Nekolla
authors.affiliation: Department of Hematology and Oncology, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Klein
authors.affiliation: Department of Hematology and Oncology, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
authors.forename: Henning D
authors.initials: HD
authors.lastname: Popp
authors.affiliation: Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
authors.forename: Mathias
authors.initials: M
authors.lastname: Meyer
authors.affiliation: Medical Radiation Physics/Radiation Protection, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University , Mannheim, Germany.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Glatting
authors.affiliation: Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Hagelstein
authors.affiliation: Department of Hematology and Oncology, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
authors.forename: Wolf K
authors.initials: WK
authors.lastname: Hofmann
authors.affiliation: Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
authors.forename: Stefan O
authors.initials: SO
authors.lastname: Schoenberg
authors.affiliation: Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Henzler
mesh_terms: D000293:Adolescent; D000328:Adult; D003952:Diagnostic Imaging / Q000009:adverse effects*; D005260:Female; D006689:Hodgkin Disease / Q000000981:diagnostic imaging*; D006801:Humans; D015993:Life Tables; D016403:Lymphoma, Large B-Cell, Diffuse / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology*; D011829:Radiation Dosage; D000069079:Radiation Exposure; D012306:Risk; D055815:Young Adult