title: [Pathological profiles of retinoblastoma in Senegal].
abstract: OBJECTIVE
  Describe the macroscopic and microscopic profiles of retinoblastoma (RB) in Senegal and correlate histological criteria with progression to establish severity factors.
  
  
  METHODS
  We realized a retrospective study over 10 years (January 2005-December 2014). Only patients (n=67) who underwent histological analysis of the enucleation specimen (n=68) were followed until the end of the study.
  
  
  RESULTS
  The tumor measured an average of 3.8cm (2/4.5). Endophytic tumor development was observed in 55 cases (80.8%), exophytic in 6 cases (8.9%) and mixed in 7 cases (10.3%). Retinal detachment was present in 13 cases (19.2%). The RB was well differentiated in 11 cases (16.2%), moderately differentiated in 31 cases (45.6%) and undifferentiated in 26 cases. Optic nerve (ON) invasion was present in 18 cases (26.5%). The tumor was extraretinal in 37 cases (54.4%). The anterior chamber was invaded in 6 cases (8.8%). The global survival at 2 years was 84% and 70% at 5 years. On multivariate analysis, well differentiated tumors and stage pT1 were associated with remission. Retrolaminar ON invasion, massive choroidal invasion and stage pT3 were risk factors for recurrence. Poor tumor differentiation, invasion of the ON resection margin, tumor invasion through the sclera, and stage pT4 were predictive of death.
  
  
  CONCLUSIONS
  The pathologist is a principal actor in the management of RB because his account guide the post-surgical management strategy.
authors.affiliation: Laboratoire d'anatomie et cytologie pathologiques, hôpital de Grand-Yoff, BP 3270 Grand-Yoff, Dakar, Sénégal.
authors.forename: C
authors.initials: C
authors.lastname: Dial
authors.affiliation: Laboratoire d'anatomie et cytologie pathologiques, hôpital Aristide Le Dantec, pavillon Bichat, avenue Pasteur, BP 3001, Dakar, Sénégal. Electronic address: kwame.doh@ucad.edu.sn.
authors.forename: K
authors.initials: K
authors.lastname: Doh
authors.affiliation: Laboratoire d'anatomie et cytologie pathologiques, hôpital Aristide Le Dantec, pavillon Bichat, avenue Pasteur, BP 3001, Dakar, Sénégal.
authors.forename: I
authors.initials: I
authors.lastname: Thiam
authors.affiliation: Service d'ophtalmologie, hôpital Aristide Le Dantec, Dakar, Sénégal.
authors.forename: P
authors.initials: P
authors.lastname: Ndoye Roth
authors.affiliation: Service d'oncologie pédiatrique, hôpital Aristide Le Dantec, Dakar, Sénégal.
authors.forename: C
authors.initials: C
authors.lastname: Moreira
authors.affiliation: Laboratoire d'anatomie et cytologie pathologiques, hôpital Aristide Le Dantec, pavillon Bichat, avenue Pasteur, BP 3001, Dakar, Sénégal.
authors.forename: G
authors.initials: G
authors.lastname: Woto-Gaye
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D019572:Retinal Neoplasms / Q000453:epidemiology / Q000473:pathology*; D012175:Retinoblastoma / Q000453:epidemiology / Q000473:pathology*; D012189:Retrospective Studies; D012675:Senegal / Q000453:epidemiology; D012720:Severity of Illness Index; D016019:Survival Analysis
keywords: Death; Décès; Facteurs histopronostiques; Histological prognostic factors; Recurrence; Retinoblastoma; Récidive; Rétinoblastome; Senegal; Sénégal