title: Association of Serum Ferritin Levels with Hematological Manifestations in Systemic Lupus Erythematosus Patients from Western India.
abstract: To identify the hematological manifestations and its association with serum ferritin levels in SLE patients from Western India.
  
  
  
  Ninety clinically diagnosed SLE patients fulfilling ACR criteria were included. Disease activity was assessed at the time of evaluation using Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Sera were tested for serum ferritin levels by ELISA (Calbiotech, USA). Autoantibodies such as ANA, anti-dsDNA by indirect immunofluorescence test (IFA- Bio-Rad, USA) and anti-cardiolipin antibodies (ACA) to IgG and IgM isotypes and Anti-β2 GP antibodies to IgG and IgM isotypes were detected by ELISA using commercially available kits (Euroimmun, Lubeck, Germany).
  
  
  
  Out of 90 SLE patients studied, 41 patients (45.6%) showed hematological abnormalities, where anemia (82.9%), leucopenia (26.8%), autoimmune hemolytic anemia (AIHA) (14.6%) and idiopathic thrombocytopenic purpura (ITP) were noted in (34.1%) patients. Mean±SD serum ferritin levels among SLE patients were 270.2±266.0 ng/ml as compared to 29.0±15.8 ng/ml healthy normal controls (p<0.0001). A positive correlation between serum ferritin levels and SLEDAI scores (r= 0.2640, p=0.0124) and anti-dsDNA positivity was noted (r=0.32, p<0.0001). Serum ferritin levels were negatively correlated with hemoglobin levels (r=-0.5964, p=0.0001), WBC count (r=-0.1705, p=0.2316), platelet count ((r=-0.1701, P=0.2375), C3 levels (r=-0.4417, p=0.0034) and C4 levels (r=-0.0363, p=0.8215).
  
  
  
  Serum ferritin is an excellent marker of SLE which can be used for an evaluation of disease activity particularly in active stage of the disease mainly in patients having hematological and renal manifestations.
authors.affiliation: Scientist.
authors.forename: Vandana
authors.initials: V
authors.lastname: Pradhan
authors.affiliation: Senior Research Fellow, Department of Clinical and Experimental Immunology, National Institute of Immunohematology, Mumbai, Maharashtra.
authors.forename: Pallavi
authors.initials: P
authors.lastname: Pandit
authors.affiliation: Professor of Medicine, KEM Hospital, Mumbai, Maharashtra.
authors.forename: Anjali
authors.initials: A
authors.lastname: Rajadhyaksha
authors.affiliation: Technical Assistant.
authors.forename: Manisha
authors.initials: M
authors.lastname: Patwardhan
authors.affiliation: Research Technician, Department of Clinical and Experimental Immunology.
authors.forename: Prathamesh
authors.initials: P
authors.lastname: Surve
authors.affiliation: Trainee, National Institute of Immunohaematology, Mumbai, Maharashtra.
authors.forename: Pradnya
authors.initials: P
authors.lastname: Kamble
authors.affiliation: Biomedical Engineer.
authors.forename: Maxime
authors.initials: M
authors.lastname: Lecerf
authors.affiliation: Scientist, Biomedical Engineer.
authors.forename: Jagadeesh
authors.initials: J
authors.lastname: Bayry
authors.affiliation: Director, INSERM, UMR-S 1138, Centre de Recherche des Cordeliers, Université Pierre et Marie Curie - Paris 6, F-75006, France.
authors.forename: Srinivas
authors.initials: S
authors.lastname: Kaveri
authors.affiliation: Ex-Director, National Institute of Immunohematology, Mumbai, Maharashtra.
authors.forename: K
authors.initials: K
authors.lastname: Ghosh
authors.affiliation: Professor, Dept. of Medicine and Head of Rheumatology, Seth GS Medical College & KEM Hospital, Mumbai, Maharashtra.
authors.forename: Milind Y
authors.initials: MY
authors.lastname: Nadkar
mesh_terms: D000293:Adolescent; D000328:Adult; D000740:Anemia / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D000974:Antibodies, Antinuclear / Q000097:blood* / Q000276:immunology; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D002648:Child; D003181:Complement C4 / Q000032:analysis* / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007132:Immunoglobulin Isotypes / Q000097:blood / Q000276:immunology*; D007075:Immunoglobulin M / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010976:Platelet Count
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D015415:Biomarkers; D003181:Complement C4; D007074:Immunoglobulin G; D007132:Immunoglobulin Isotypes; D007075:Immunoglobulin M; D005293:Ferritins