title: Molecular Cancer Imaging with Polymeric Nanoassemblies: From Tumor Detection to Theranostics.
abstract: Several imaging modalities have been widely applied for the detection of cancer and its pathological activity in combination with probes capable of improving the contrast between healthy and cancerous tissues. Biocompatible polymeric nanoassemblies have been developed for precise detection of malignant tumors by enhancing the selectivity and sensitivity of the imaging. Exploiting the compartmentalized structure of the nanoassemblies advantageously allows delivering both imaging and therapeutic agents for cancer multifunctional imaging and theranostics, i.e., the combination of therapy and diagnosis tool on a single platform. Thus, nanoassemblies have high potential not only for cancer molecular imaging but also for tracing nanoparticles in biological systems, studying their biological pathways, gathering pathological information, monitoring therapeutic effects, and guiding pinpoint therapies. In this review, polymeric nanoassemblies for optical imaging, magnetic resonance imaging, multifunctional imaging, and image-guided therapy, emphasizing their role in cancer diagnosis and theranostics are highlighted.
authors.affiliation: State Key Laboratory of Biotherapy and Cancer Center and Department of Cardiovascular Surgery, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, P. R. China.
authors.forename: Peng
authors.initials: P
authors.lastname: Mi
authors.affiliation: State Key Laboratory of Biotherapy and Cancer Center and Department of Cardiovascular Surgery, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, P. R. China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.affiliation: Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, R1-11, 4259 Nagatsuta, Midori-ku, Yokohama, 226-8503, Japan.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Nishiyama
authors.affiliation: Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
authors.forename: Horacio
authors.initials: H
authors.lastname: Cabral
mesh_terms: D000818:Animals; D006801:Humans; D057054:Molecular Imaging / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D011108:Polymers / Q000737:chemistry*; D000068936:Theranostic Nanomedicine / Q000379:methods*; D057170:Translational Research, Biomedical
chemical_list: D011108:Polymers
keywords: MRI; cancer; fluorescence imaging; neutron capture therapy; polymeric micelles; theranostics