title: Altered interregional correlations between serotonin transporter availability and cerebral glucose metabolism in schizophrenia: A high-resolution PET study using [11C]DASB and [18F]FDG.
abstract: The purpose of the present study was to investigate the patterns of interregional correlations of serotonin transporter (SERT) availability with glucose metabolism using 7-Tesla magnetic resonance imaging (MRI) and high-resolution positron emission tomography (PET) with11C-3-amino-4-(2-dimethylaminomethylphenylthio)benzonitrile ([11C]DASB) and [18F]fluorodeoxyglucose ([18F]FDG) in antipsychotic-free patients with schizophrenia in order to shed new light on the disrupted functional connectivity in schizophrenia. Nineteen patients with schizophrenia and 18 healthy controls underwent high-resolution PET and MRI. The binding potential (BPND) of [11C]DASB and standardized uptake value ratio (SUVR) of [18F]FDG were obtained. In SERT availability, the region of interest (ROI)-based analyses showed no significant group differences in any region, except for the anterior hippocampus where the SERT availability was lower in patients with schizophrenia than in controls. The ROI- and voxel-based analyses revealed that the [18F]FDG SUVR values were significantly lower in patients than in controls in the right superior frontal gyrus and medial part of the left superior frontal gyrus. Regarding the interregional correlations of [11C]DASB BPNDwith [18F]FDG SUVR, more widespread positive correlations across the brain regions were observed in control subjects than in patients with schizophrenia. Notably, the patients and control subjects showed statistically significant differences in correlations between the SERT availability in the parietal and temporal cortices and the glucose metabolism in the posterior cingulate cortex. These results suggest abnormal functional connectivity between the higher-order cortical regions in schizophrenia and a possible important role of the posterior cingulate gyrus and its related circuitry in the pathophysiology of schizophrenia.
authors.affiliation: Research Institute for Advanced Industrial Technology, Korea University, Sejong, Republic of Korea; Neuroscience Research Institute, Gachon University, Incheon, Republic of Korea.
authors.forename: Jeong-Hee
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Neuroscience Research Institute, Gachon University, Incheon, Republic of Korea; Department of Psychiatry, Gachon University Gil Medical Center, Gachon University School of Medicine, Incheon, Republic of Korea. Electronic address: jhnp@chol.com.
authors.forename: Jong-Hoon
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Neuroscience Research Institute, Gachon University, Incheon, Republic of Korea; Department of Biomedical Engineering, College of Health Science, Gachon University, Incheon, Republic of Korea.
authors.forename: Young-Don
authors.initials: YD
authors.lastname: Son
authors.affiliation: Neuroscience Research Institute, Gachon University, Incheon, Republic of Korea.
authors.forename: Yo-Han
authors.initials: YH
authors.lastname: Joo
authors.affiliation: Neuroscience Research Institute, Gachon University, Incheon, Republic of Korea; Department of Radiological Science, College of Health Science, Gachon University, Incheon, Republic of Korea.
authors.forename: Sang-Yoon
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Neuroscience Research Institute, Gachon University, Incheon, Republic of Korea; Department of Biomedical Engineering, College of Health Science, Gachon University, Incheon, Republic of Korea.
authors.forename: Hang-Keun
authors.initials: HK
authors.lastname: Kim
authors.affiliation: Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea; Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, USA.
authors.forename: Myung-Kyun
authors.initials: MK
authors.lastname: Woo
mesh_terms: D000328:Adult; D001596:Benzylamines / Q000493:pharmacokinetics; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D005500:Follow-Up Studies; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011569:Psychiatric Status Rating Scales; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D012559:Schizophrenia / Q000000981:diagnostic imaging* / Q000378:metabolism*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*
chemical_list: D001596:Benzylamines; C420885:N,N-dimethyl-2-(2-amino-4-cyanophenylthio)benzylamine; D019275:Radiopharmaceuticals; D050486:Serotonin Plasma Membrane Transport Proteins; D019788:Fluorodeoxyglucose F18; D005947:Glucose
keywords: Glucose metabolism; Schizophrenia; Serotonin transporter availability; [(11)C]DASB; [(18)F]FDG