title: Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis.
abstract: Motor neuron disease is one of the major groups of neurodegenerative diseases, mainly represented by amyotrophic lateral sclerosis. Despite wide genetic and biochemical data regarding its pathophysiological mechanisms, motor neuron disease develops under a complex network of mechanisms not restricted to the unique functions of the alpha motor neurons but which actually involve diverse functions of glial cell interaction. This review aims to expose some of the leading roles of glial cells in the physiological mechanisms of neuron-glial cell interactions and the mechanisms related to motor neuron survival linked to glial cell functions.
authors.affiliation: Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, São Paulo SP, Brasil.
authors.forename: Paulo Victor Sgobbi de
authors.initials: PV
authors.lastname: Souza
authors.affiliation: Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, São Paulo SP, Brasil.
authors.forename: Wladimir Bocca Vieira de Rezende
authors.initials: WB
authors.lastname: Pinto
authors.affiliation: Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, São Paulo SP, Brasil.
authors.forename: Flávio Moura
authors.initials: FM
authors.lastname: Rezende
authors.affiliation: Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, São Paulo SP, Brasil.
authors.forename: Acary Souza Bulle
authors.initials: AS
authors.lastname: Oliveira
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000473:pathology* / Q000503:physiopathology*; D018698:Glutamic Acid / Q000502:physiology; D006801:Humans; D008488:Medical Illustration; D009046:Motor Neurons / Q000737:chemistry / Q000502:physiology*; D009414:Nerve Growth Factors / Q000502:physiology; D009457:Neuroglia / Q000737:chemistry / Q000502:physiology*
chemical_list: D009414:Nerve Growth Factors; D018698:Glutamic Acid