title: Antimicrobial AApeptides.
abstract: Antibiotic resistance is one of the biggest public concerns in the 21st century. Host-defense peptides (HDPs) can potentially mitigate the problem through bacterial membrane disruption; however, they suffer from moderate activity and low stability. We recently developed a new class of peptidomimetics termed "AApeptides". This class of peptidomimetics can mimic the mechanism of action of HDPs, and effectively arrest the growth of multidrug resistant Gram-positive and Gram-negative bacteria. As they are built on unnatural backbone, they are resistant to proteolytic degradation. In this review, we summarize the development of this class of antimicrobial peptidomimetics, and discuss the future perspective on how they can move forward on combating antibiotic resistance.
authors.affiliation: Department of Chemistry, University of South Florida, Tampa, FL, 33260, United States.
authors.forename: Peng
authors.initials: P
authors.lastname: Sang
authors.affiliation: Department of Chemistry, University of South Florida, Tampa, FL, 33260, United States.
authors.forename: Yan
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Chemistry, University of South Florida, Tampa, FL, 33260, United States.
authors.forename: Peng
authors.initials: P
authors.lastname: Teng
authors.affiliation: Department of Chemistry, University of South Florida, Tampa, FL, 33260, United States.
authors.forename: Annie
authors.initials: A
authors.lastname: Cao
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha, HN 410083, China.
authors.forename: Hai
authors.initials: H
authors.lastname: Xu
authors.affiliation: Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Chemistry, University of South Florida, Tampa, United States.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Cai
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D057786:Peptidomimetics / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D057786:Peptidomimetics
keywords: AApeptides; Antibiotic resistance; Antimicrobial activity; Host-defense peptides (HDPs); Peptidomimetics