title: Biomarkers of Key Biological Pathways in CVD.
abstract: This review provides background on the laboratory design for MESA (Multi-Ethnic Study of Atherosclerosis) as well as the approach used in MESA to select biomarkers for measurement. The research related to the multitude of circulating and urinary biomarkers of inflammation and other novel and emerging biological pathways in MESA is summarized by domain, or pathway, represented by the biomarker. The contributions of MESA biomarkers to our knowledge of these key pathways in the development and progression of atherosclerosis, cardiovascular disease, diabetes, kidney disease, and pulmonary disease are highlighted, as are the contributions of MESA to recommendations for clinical use of several of these biomarkers. In addition, contributions of MESA to multicohort genomics consortia and current collaborations in transomics and metabolomics are noted.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT, USA. Electronic address: Nancy.Jenny@med.uvm.edu.
authors.forename: Nancy Swords
authors.initials: NS
authors.lastname: Jenny
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT, USA.
authors.forename: Nels C
authors.initials: NC
authors.lastname: Olson
authors.affiliation: Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA, USA.
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Allison
authors.affiliation: Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA, USA.
authors.forename: Dena E
authors.initials: DE
authors.lastname: Rifkin
authors.affiliation: Department of Medicine, Division of Cardiovascular Medicine, University of California, San Diego, CA, USA.
authors.forename: Lori B
authors.initials: LB
authors.lastname: Daniels
authors.affiliation: Kidney Research Institute, University of Washington, Seattle, WA, USA.
authors.forename: Ian H
authors.initials: IH
authors.lastname: de Boer
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT, USA.
authors.forename: Christina L
authors.initials: CL
authors.lastname: Wassel
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT, USA; Department of Biochemistry, University of Vermont College of Medicine, Burlington, VT, USA.
authors.forename: Russell P
authors.initials: RP
authors.lastname: Tracy
mesh_terms: D058186:Acute Kidney Injury / Q000208:ethnology / Q000503:physiopathology; D054392:Adipokines / Q000378:metabolism; D000465:Algorithms; D050197:Atherosclerosis / Q000208:ethnology / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000208:ethnology / Q000378:metabolism*; D002908:Chronic Disease; D004730:Endothelium, Vascular / Q000502:physiology; D005227:Fatty Acids / Q000378:metabolism; D005342:Fibrinolysis / Q000502:physiology; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007239:Infections / Q000208:ethnology; D007333:Insulin Resistance / Q000502:physiology; D050356:Lipid Metabolism / Q000502:physiology; D008214:Lymphocytes / Q000276:immunology; D008903:Minerals / Q000378:metabolism; D020097:Natriuretic Peptide, Brain / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology; D010446:Peptide Fragments / Q000378:metabolism; D058226:Plaque, Atherosclerotic / Q000208:ethnology / Q000378:metabolism; D012084:Renin-Angiotensin System / Q000502:physiology; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D020107:Troponin T / Q000378:metabolism; D014815:Vitamins / Q000378:metabolism
chemical_list: D054392:Adipokines; D015415:Biomarkers; D005227:Fatty Acids; D012739:Gonadal Steroid Hormones; D008903:Minerals; D010446:Peptide Fragments; D020107:Troponin T; D014815:Vitamins; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain