title: The Relationship between Metabolic Parameters, Cardiac Parameters and MIC-1/GDF15 in Obese Children.
abstract: Objective:Childhood obesity which is a predictor of adulthood obesity is associated with type 2 diabetes, metabolic syndrome, dyslipidemia, coronary artery diseases and subclinical inflammation. Growth differentiation factor-15, also known as macrophage inhibitory cytokine-1 (MIC-1/GDF15) is a member of the transforming growth factor- β super family and increases during inflammatory states. Adults with obesity have increased serum concentrations of MIC-1/GDF15. MIC-1/GDF15 is associated with cardio metabolic risk in adults.Design:Identification of obese children at higher risk for cardio metabolic complications is important. The relations of MIC-1/GDF15 to parameters of obesity in children have never been studied.Methods:We measured serum MIC-1/GDF15 concentration in obese children by ELİSA and evaluated its relationship with anthropometric, biochemical and echocardiographic parameters.Results:No significant difference in serum MIC-1/GDF15 between normal-weight and obese children was observed. MIC-1/GDF15 was positively correlated with CRP, ALT and aortic dimension when normal-weight and obese children were analyzed together.Conclusions:MIC-1/GDF15 may provide a link between childhood obesity and cardio metabolic complications that will occur in time course. Further work would be required to find out if MIC-1/GDF15 has any role in the early inflammatory, cardiac and metabolic changes in childhood obesity.
authors.affiliation: Department of Pediatric Endocrinology, Selçuk University Medical School, Selçuklu, Turkey.
authors.forename: S A
authors.initials: SA
authors.lastname: Yuca
authors.affiliation: Department of Pediatric Endocrinology, Selçuk University Medical School, Selçuklu, Turkey.
authors.forename: E A
authors.initials: EA
authors.lastname: Cimbek
authors.affiliation: Department of Pediatric Endocrinology, Selçuk University Medical School, Selçuklu, Turkey.
authors.forename: Y
authors.initials: Y
authors.lastname: Şen
authors.affiliation: Department of Pediatric Cardiology, Selçuk University Medical School, Selçuklu, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Güvenç
authors.affiliation: Department of Biochemistry, Selçuk University Medical School, Selçuklu, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Vatansev
authors.affiliation: Department of Pediatric Endocrinology, Selçuk University Medical School, Selçuklu, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Buğrul
authors.affiliation: Department of Biochemistry, Selçuk University Medical School, Selçuklu, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Gün
authors.affiliation: Department of Pediatric Cardiology, Selçuk University Medical School, Selçuklu, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Oran
mesh_terms: D000293:Adolescent; D000328:Adult; D001011:Aorta / Q000473:pathology; D044466:Asian People; D002648:Child; D002681:China; D005260:Female; D055436:Growth Differentiation Factor 15 / Q000097:blood*; D006331:Heart Diseases / Q000097:blood* / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D009765:Obesity / Q000097:blood* / Q000150:complications* / Q000473:pathology
chemical_list: C526140:GDF15 protein, human; D055436:Growth Differentiation Factor 15