title: Bone mineral density and microarchitecture in patients with essential thrombocythemia and polycythemia vera.
abstract: In this cross-sectional study of 45 patients with myeloproliferative neoplasms, we found no evidence of secondary osteoporosis.
  
  
  
  Patients with essential thrombocythemia (ET) and polycythaemia vera (PV) are at increased risk of fractures but the underlying mechanisms have not been settled. We conducted a study to assess bone mineral density, microarchitecture, estimated bone strength and global bone turnover in 45 patients with ET or PV.
  
  
  
  Patients were evaluated in a cross-sectional study with dual energy X-ray absorptiometry (DXA) at the hip and spine; high-resolution peripheral quantitative computed tomography (HR-pQCT) at the distal radius and distal tibia; and biochemical markers of bone turnover including pro-collagen type 1 N-terminal pro-peptide, osteocalcin, C-terminal cross-linking telopeptide of type 1 collagen and bone-specific alkaline phosphatase. Also, 45 healthy comparisons, matched on age, height and weight with each patient were included as control subjects.
  
  
  
  Patients and comparisons had almost identical BMDs: 0.96 (IQR: 0.85-1.07) g/cm2and 0.96 g/cm2(IQR: 0.86-1.05 g/cm2), respectively. As well all microarchitecture and estimated bone strength measures were highly similar in the two groups. Levels of bone turnover markers were within reference values in patients.
  
  
  
  These results reveal no evidence of secondary osteoporosis among patients with ET or PV. The mechanism behind the increased fracture risk in ET or PV patients remains unknown.
authors.affiliation: Department of Haematology, Odense University Hospital, Sdr. Boulevard 29, DK-5000, Odense, Denmark. mailtilsarah@yahoo.com.
authors.forename: S
authors.identifier: http://orcid.org/0000-0001-7525-7765
authors.initials: S
authors.lastname: Farmer
authors.affiliation: Department of Endocrinology, Odense University Hospital, Odense, Denmark.
authors.forename: V V
authors.initials: VV
authors.lastname: Shanbhogue
authors.affiliation: Department of Endocrinology, Odense University Hospital, Odense, Denmark.
authors.forename: S
authors.initials: S
authors.lastname: Hansen
authors.affiliation: Department of Pathology, Odense University Hospital, Odense, Denmark.
authors.forename: C I
authors.initials: CI
authors.lastname: Stahlberg
authors.affiliation: Department of Haematology, Odense University Hospital, Sdr. Boulevard 29, DK-5000, Odense, Denmark.
authors.forename: H
authors.initials: H
authors.lastname: Vestergaard
authors.affiliation: Department of Endocrinology, Odense University Hospital, Odense, Denmark.
authors.forename: A P
authors.initials: AP
authors.lastname: Hermann
authors.affiliation: Department of Haematology, Odense University Hospital, Sdr. Boulevard 29, DK-5000, Odense, Denmark.|Department of Clinical Epidemiology, Aarhus University Hospital, Odense, Denmark.
authors.forename: H
authors.initials: H
authors.lastname: Frederiksen
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D000328:Adult; D000368:Aged; D015519:Bone Density / Q000502:physiology*; D016723:Bone Remodeling / Q000502:physiology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006621:Hip Joint / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011087:Polycythemia Vera / Q000473:pathology / Q000503:physiopathology*; D013920:Thrombocythemia, Essential / Q000473:pathology / Q000503:physiopathology*; D014057:Tomography, X-Ray Computed / Q000379:methods; D055815:Young Adult
keywords: Bone mineral density; Chronic myeloproliferative neoplasms; Essential thrombocythemia; Microarchitecture; Polycythemia vera