title: Extensive Diminution of Particle Size and Amorphization of a Crystalline Drug Attained by Eminent Technology of Solid Dispersion: A Comparative Study.
abstract: The present study emphasized on the use of solid dispersion technology to triumph over the drawbacks associated with the highly effective antihypertensive drug telmisartan using different polymers (poloxamer 188 and locust bean gum) and methods (modified solvent evaporation and lyophilization). It is based on the comparison between selected polymers and methods for enhancing solubility through particle size reduction. The results showed different profiles for particle size, solubility, and dissolution of formulated amorphous systems depicting the great influence of polymer/method used. The resulting amorphous solid dispersions were characterized using x-ray diffraction (XRD), differential scanning calorimetry, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and particle size analysis. The optimized solid dispersion (TEL 19) prepared with modified locust bean gum using lyophilization technique showed reduced particle size of 184.5 ± 3.7 nm and utmost solubility of 702 ± 5.47 μg/mL in water, which is quite high as compared to the pure drug (≤1 μg/mL). This study showed that the appropriate selection of carrier may lead to the development of solid dispersion formulation with desired solubility and dissolution profiles. The optimized dispersion was later formulated into fast-dissolving tablets, and further optimization was done to obtain the tablets with desired properties.
authors.affiliation: Department of Pharmaceutical Sciences, IKG Punjab Technical University, Kapurthala, 144603, Punjab, India.
authors.forename: Gurjeet
authors.initials: G
authors.lastname: Singh
authors.affiliation: Department of Pharmaceutical Sciences, ASBASJSM College of Pharmacy, Bela, Ropar, 140111, Punjab, India.
authors.forename: Shailesh
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Department of Pharmaceutical Sciences, ASBASJSM College of Pharmacy, Bela, Ropar, 140111, Punjab, India. sainigurjeet21@gmail.com.
authors.forename: Ghanshyam Das
authors.initials: GD
authors.lastname: Gupta
mesh_terms: D001562:Benzimidazoles / Q000737:chemistry*; D001565:Benzoates / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning / Q000379:methods; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003460:Crystallization / Q000379:methods; D005685:Galactans / Q000737:chemistry; D008351:Mannans / Q000737:chemistry; D008855:Microscopy, Electron, Scanning / Q000379:methods; D010316:Particle Size; D053149:Plant Gums / Q000737:chemistry; D012995:Solubility; D012997:Solvents; D000077333:Telmisartan; D014961:X-Ray Diffraction / Q000379:methods
chemical_list: D001562:Benzimidazoles; D001565:Benzoates; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; D012997:Solvents; D000077333:Telmisartan; C017471:locust bean gum
keywords: amorphous; dissolution rate; fast-dissolving tablet; lyophilization; poloxamer 188