title: The role of osteoclasts in breast cancer bone metastasis.
abstract: Breast cancer frequently metastasises to the skeleton, interfering with the normal bone remodelling process and inducing bone degradation. Bone degradation is caused by osteoclasts, the normal bone-resorbing cells. Osteoclast-mediated bone degradation subsequently leads to the release of bone-derived factors that promote skeletal tumour growth. Osteoclasts themselves stimulate tumour growth. This Review describes the molecular mechanisms through which osteoclasts and breast cancer cells collaborate with each other, triggering the formation of osteolytic bone metastasis.
authors.affiliation: INSERM, UMR 1033, Lyon F-69372, France; Université Lyon-1, Villeurbanne F-69622, France.
authors.forename: François
authors.initials: F
authors.lastname: Le Pape
authors.affiliation: INSERM, UMR 1033, Lyon F-69372, France; Université Lyon-1, Villeurbanne F-69622, France.
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Vargas
authors.affiliation: INSERM, UMR 1033, Lyon F-69372, France; Université Lyon-1, Villeurbanne F-69622, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Clézardin
keywords: Bone resorption; OPG; PTHrP; RANK; RANKL; miRNA