title: The chemokine CXCR2 antagonist (AZD5069) preserves neutrophil-mediated host immunity in non-human primates.
authors.affiliation: The IMED Respiratory, Inflammation & Autoimmunity Unit, AstraZeneca Gothenburg, Mölndal, Sweden.
authors.forename: Mohib
authors.initials: M
authors.lastname: Uddin
authors.affiliation: Drug Safety and Metabolism, AstraZeneca R&D, Cambridge, U.K. catherine.betts@astrazeneca.com.
authors.forename: Catherine
authors.initials: C
authors.lastname: Betts
authors.affiliation: Drug Safety and Metabolism, AstraZeneca R&D, Cambridge, U.K.
authors.forename: Ian
authors.initials: I
authors.lastname: Robinson
authors.affiliation: The IMED Respiratory, Inflammation & Autoimmunity Unit, AstraZeneca Gothenburg, Mölndal, Sweden.
authors.forename: Anna
authors.initials: A
authors.lastname: Malmgren
authors.affiliation: Drug Safety and Metabolism, AstraZeneca R&D, Cambridge, U.K.
authors.forename: Charles
authors.initials: C
authors.lastname: Humfrey
mesh_terms: D000284:Administration, Oral; D000818:Animals; D054360:Chemokine CXCL1 / Q000235:genetics / Q000276:immunology; D004334:Drug Administration Schedule; D005260:Female; D005786:Gene Expression Regulation; D016179:Granulocyte Colony-Stimulating Factor / Q000235:genetics / Q000276:immunology; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000235:genetics / Q000276:immunology; D007113:Immunity, Innate / Q000187:drug effects; D007371:Interferon-gamma / Q000235:genetics / Q000276:immunology; D015850:Interleukin-6 / Q000235:genetics / Q000276:immunology; D016209:Interleukin-8 / Q000819:agonists / Q000235:genetics / Q000276:immunology*; D007958:Leukocyte Count; D008252:Macaca fascicularis; D008297:Male; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects*; D011743:Pyrimidines / Q000494:pharmacology*; D023063:Receptors, Interleukin-8B / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology*; D016897:Respiratory Burst / Q000187:drug effects*; D015398:Signal Transduction; D013449:Sulfonamides / Q000494:pharmacology*; D036401:Toxicity Tests, Chronic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000276:immunology
chemical_list: D054360:Chemokine CXCL1; D015850:Interleukin-6; D016209:Interleukin-8; C000597960:N-(2-(2,3-difluoro-6-benzylthio)-6-(3,4-dihydroxybutan-2-yloxy)pyrimidin-4-yl)azetidine-1-sulfonamide; D011743:Pyrimidines; D023063:Receptors, Interleukin-8B; D013449:Sulfonamides; D014409:Tumor Necrosis Factor-alpha; D016179:Granulocyte Colony-Stimulating Factor; D007371:Interferon-gamma; D016178:Granulocyte-Macrophage Colony-Stimulating Factor