title: Current trends in anesthesia for esophagectomy.
abstract: OBJECTIVE
  Despite marked improvements in perioperative outcomes, esophagectomy continues to be a high-risk operation associated with significant morbidity and mortality. Progress has been achieved through evidence-based changes in preoperative optimization, intraoperative ventilation strategies, fluid therapy, and analgesia, as well as expedited postoperative recovery pathways. This review will summarize the recent literature on the anesthetic management of patients undergoing esophageal resection.
  
  
  RESULTS
  The current focus in publications on the perioperative management of esophagectomy patients can be summarized under the umbrella term of enhanced recovery pathways, focusing on ventilation, fluid therapy, analgesia and minimally invasive surgical approaches. Lung protective ventilation reduces pulmonary complications in cases requiring one-lung ventilation. Excess fluid administration contributes to morbidity while restrictive approaches have not resulted in an increased risk of acute kidney injury. Goal-directed fluid therapy remains intuitive yet unproven. Thoracic epidural analgesia reduces the systemic inflammatory response, pulmonary complications, and enhances postoperative pain control, yet if causing perioperative hypotension may be associated with anastomotic leaks. Enhanced recovery pathways have facilitated low morbidity and mortality rates in a high-risk population but are heterogeneous and limited by a weak evidence base. Minimally invasive surgical approaches are increasingly popular and appear to have at least equivalent outcomes to open procedures.
  
  
  CONCLUSIONS
  The morbidity and mortality after esophagectomy remains high despite significant improvements over the last decades. Enhanced recovery pathways appear promising in achieving further marginal gains but at present are lacking large scale, prospective, multicenter evidence.
authors.affiliation: Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver General Hospital, Vancouver, British Columbia, V5Z-1M9, Canada.
authors.forename: Chris
authors.initials: C
authors.lastname: Durkin
authors.forename: Travis
authors.initials: T
authors.lastname: Schisler
authors.forename: Jens
authors.initials: J
authors.lastname: Lohser
mesh_terms: D000367:Age Factors; D000368:Aged; D000698:Analgesia / Q000379:methods / Q000592:standards / Q000639:trends; D000758:Anesthesia / Q000379:methods / Q000592:standards / Q000639:trends*; D004938:Esophageal Neoplasms / Q000601:surgery*; D016629:Esophagectomy / Q000009:adverse effects* / Q000379:methods; D019317:Evidence-Based Medicine / Q000379:methods / Q000592:standards / Q000639:trends; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects / Q000379:methods / Q000639:trends; D018802:Patient-Centered Care / Q000379:methods / Q000592:standards / Q000639:trends; D019990:Perioperative Care / Q000379:methods / Q000592:standards / Q000639:trends; D059035:Perioperative Period / Q000401:mortality*; D013906:Thoracoscopy / Q000009:adverse effects / Q000379:methods / Q000639:trends