title: Hedgehog signaling in the stomach.
abstract: The Hedgehog (Hh) signaling pathway not only plays a key part in controlling embryonic development, but in the adult stomach governs important cellular events such as epithelial cell differentiation, proliferation, gastric disease, and regeneration. In particular, Sonic Hedgehog (Shh) signaling has been well studied for its role in gastric physiology and pathophysiology. Shh is secreted from the gastric parietal cells and contributes to the regeneration of the epithelium in response to injury, or the development of gastritis during Helicobacter pylori infection. Dysregulation of the Shh signaling pathway leads to the disruption of gastric differentiation, loss of gastric acid secretion and the development of cancer. In this chapter, we will review the most recent findings that reveal the role of Shh as a regulator of gastric physiology, regeneration, and disease.
authors.affiliation: Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Konstantinou
authors.affiliation: Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH, USA.
authors.forename: Nina
authors.initials: N
authors.lastname: Bertaux-Skeirik
authors.affiliation: Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH, USA. Electronic address: yana.zavros@uc.edu.
authors.forename: Yana
authors.initials: Y
authors.lastname: Zavros
mesh_terms: D000328:Adult; D000818:Animals; D005753:Gastric Mucosa / Q000378:metabolism*; D005756:Gastritis / Q000382:microbiology / Q000503:physiopathology; D053823:Hedgehog Proteins / Q000378:metabolism*; D016481:Helicobacter Infections / Q000503:physiopathology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D015398:Signal Transduction; D013270:Stomach / Q000503:physiopathology; D013272:Stomach Diseases / Q000503:physiopathology*; D013274:Stomach Neoplasms / Q000503:physiopathology
chemical_list: D053823:Hedgehog Proteins; C509239:SHH protein, human