title: Outbreak of hand, foot, and mouth disease caused by coxsackievirus A6 in a Juku in Fengtai District, Beijing, China, 2015.
abstract: An outbreak of hand, foot, and mouth disease (HFMD) that occurred in a Juku in Fengtai District, Beijing, China, in 2015 was monitored by the China Information System for Disease Control and Prevention. Epidemiological investigation showed that 11 cases occurred from two classes in the preschool art training department in the Juku. Coxsackievirus A6 (CV-A6) was identified as the causative pathogen of the outbreak via sequences analysis of products of real-time reverse-transcription polymerase chain reaction (RT-PCR) and nested RT-PCR. Phylogenetic analysis showed that CV-A6 strains isolated in this study clustered with epidemic strains isolated in China since 2013. The outbreak ended quickly with effective measures. This event indicates that continuous surveillance of HFMD etiological agents other than enterovirus 71 and coxsackievirus A16 is necessary.
authors.affiliation: Key Laboratory for Medical Virology, Ministry of Health, National Institute for Viral Diseases Control and Prevention, China CDC, 100 Ying-Xin St., Xi-Cheng District, Beijing, 100052 China.
authors.forename: Jin-Song
authors.initials: JS
authors.lastname: Li
authors.affiliation: Fengtai District Center for Diseases Control and Prevention of Beijing, 3 Xi An St., Feng-Tai District, Beijing, 100071 China.
authors.forename: Xiao-Gen
authors.initials: XG
authors.lastname: Dong
authors.affiliation: Fengtai District Center for Diseases Control and Prevention of Beijing, 3 Xi An St., Feng-Tai District, Beijing, 100071 China.
authors.forename: Meng
authors.initials: M
authors.lastname: Qin
authors.affiliation: Fengtai District Center for Diseases Control and Prevention of Beijing, 3 Xi An St., Feng-Tai District, Beijing, 100071 China.
authors.forename: Hui-Ru
authors.initials: HR
authors.lastname: Feng
authors.affiliation: Fengtai District Center for Diseases Control and Prevention of Beijing, 3 Xi An St., Feng-Tai District, Beijing, 100071 China.
authors.forename: Jun-Yong
authors.initials: JY
authors.lastname: Yang
authors.affiliation: Fengtai District Center for Diseases Control and Prevention of Beijing, 3 Xi An St., Feng-Tai District, Beijing, 100071 China.
authors.forename: Ruo-Xi
authors.initials: RX
authors.lastname: Li
authors.affiliation: Fengtai District Center for Diseases Control and Prevention of Beijing, 3 Xi An St., Feng-Tai District, Beijing, 100071 China.
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Medical Virology, Ministry of Health, National Institute for Viral Diseases Control and Prevention, China CDC, 100 Ying-Xin St., Xi-Cheng District, Beijing, 100052 China.
authors.forename: Li-Shu
authors.initials: LS
authors.lastname: Zheng
keywords: Coxsackievirus A6; HFMD; Outbreak