title: Analytical performance bounds for multi-tensor diffusion-MRI.
abstract: To examine the effects of MR acquisition parameters on brain white matter fiber orientation estimation and parameter of clinical interest in crossing fiber areas based on the Multi-Tensor Model (MTM).
  
  
  
  We compute the Cramér-Rao Bound (CRB) for the MTM and the parameter of clinical interest such as the Fractional Anisotropy (FA) and the dominant fiber orientations, assuming that the diffusion MRI data are recorded by a multi-coil, multi-shell acquisition system. Considering the sum-of-squares method for the reconstructed magnitude image, we introduce an approximate closed-form formula for Fisher Information Matrix that has the simplicity and easy interpretation advantages. In addition, we propose to generalize the FA and the mean diffusivity to the multi-tensor model.
  
  
  
  We show the application of the CRB to reduce the scan time while preserving a good estimation precision. We provide results showing how the increase of the number of acquisition coils compensates the decrease of the number of diffusion gradient directions. We analyze the impact of the b-value and the Signal-to-Noise Ratio (SNR). The analysis shows that the estimation error variance decreases with a quadratic rate with the SNR, and that the optimum b-values are not unique but depend on the target parameter, the context, and eventually the target cost function.
  
  
  
  In this study we highlight the importance of choosing the appropriate acquisition parameters especially when dealing with crossing fiber areas. We also provide a methodology for the optimal tuning of these parameters using the CRB.
authors.affiliation: ParIMéd/LRPE, FEI, USTHB, BP 32 El Alia, Bab Ezzouar, 16111, Algiers, Algeria. Electronic address: ahmedsid.f@gmail.com.
authors.forename: Farid
authors.initials: F
authors.lastname: Ahmed Sid
authors.affiliation: PRISME Laboratory, University of Orléans, 12 Rue de Blois, 45067 Orléans, France.
authors.forename: Karim
authors.initials: K
authors.lastname: Abed-Meraim
authors.affiliation: PRISME Laboratory, University of Orléans, 12 Rue de Blois, 45067 Orléans, France.
authors.forename: Rachid
authors.initials: R
authors.lastname: Harba
authors.affiliation: ParIMéd/LRPE, FEI, USTHB, BP 32 El Alia, Bab Ezzouar, 16111, Algiers, Algeria.
authors.forename: Fatima
authors.initials: F
authors.lastname: Oulebsir-Boumghar
mesh_terms: D000465:Algorithms; D016880:Anisotropy; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods* / Q000592:standards*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008962:Models, Theoretical; D015203:Reproducibility of Results; D059629:Signal-To-Noise Ratio; D066127:White Matter / Q000033:anatomy & histology*
keywords: Cramér–Rao bound; Multi-tensor model; Multiple-receiver coils; Non-central Chi distribution