title: Cytosolic delivery of large proteins using nanoparticle-stabilized nanocapsules.
abstract: We report an effective intracellular delivery strategy for proteins of high molecular weight using AuNP stabilized capsules. This strategy provides direct delivery to the cytosol, avoiding endosomal entrapment.
authors.affiliation: Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA. rotello@chem.umass.edu.
authors.forename: Rui
authors.identifier: http://orcid.org/0000-0002-3161-801X
authors.initials: R
authors.lastname: Tang
authors.affiliation: Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA. rotello@chem.umass.edu.
authors.forename: Ziwen
authors.identifier: http://orcid.org/0000-0002-6633-7824
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA. rotello@chem.umass.edu.
authors.forename: Moumita
authors.initials: M
authors.lastname: Ray
authors.affiliation: Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA. rotello@chem.umass.edu.
authors.forename: Singyuk
authors.initials: S
authors.lastname: Hou
authors.affiliation: Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA. rotello@chem.umass.edu.
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Rotello
mesh_terms: D003600:Cytosol; D016503:Drug Delivery Systems; D011992:Endosomes; D006046:Gold; D006367:HeLa Cells; D006801:Humans; D053768:Metal Nanoparticles; D053769:Nanocapsules; D011506:Proteins / Q000008:administration & dosage*
chemical_list: D053769:Nanocapsules; D011506:Proteins; D006046:Gold