title: Effects of Excess Cr3+on Trace Element Contents in the Brain and Serum in Chicken.
abstract: This study aimed to investigate the effects of chromic chloride (CrCl3) on Ca, Mg, Mn, Fe, Cu, and Zn contents in the brain and serum of chicken. Seventy-two chickens were randomly divided into four groups and treated with different doses of CrCl3via drinking water: 0, 1/8, 1/4, and 1/2 LD50for 42 days. The contents of the elements were evaluated through inductively coupled plasma mass spectrometry. Results showed that Cr contents in the brain and serum were higher than those in the control groups, although no significant dose-dependent changes (P > 0.05) in brain of the Cr-treated groups were observed at 42 days. As exposure time was prolonged and CrCl3dosage was increased, Ca contents increased (P < 0.05). Mg and Cu contents in serum decreased; by contrast, Mg and Cu contents initially increased and then decreased in the brain. Fe and Zn contents in the serum increased; conversely, Fe and Zn contents in the brain decreased. CrCl3exposure did not significantly affect Mn contents at 14 or 28 days, but significantly decreased (P < 0.05) at 42 days. Therefore, excess Cr3+intake can disrupt absorption and deposition of other trace elements in the brain and serum; the blood-brain barrier may prevent the accumulation of these elements in the brain exposed to CrCl3.
authors.affiliation: College of Veterinary Medicine, Shandong Agricultural University, Tai'an, 271018, China.
authors.forename: Yanhan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: College of Veterinary Medicine, Shandong Agricultural University, Tai'an, 271018, China.
authors.forename: Pan
authors.initials: P
authors.lastname: Hao
authors.affiliation: College of Veterinary Medicine, Shandong Agricultural University, Tai'an, 271018, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhang
authors.affiliation: College of Veterinary Medicine, Shandong Agricultural University, Tai'an, 271018, China.
authors.forename: Xiaona
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Research Center for Animal Disease Control Engineering, Shandong Agricultural University, Tai'an, 271018, China. liuyongxia666@163.com.
authors.forename: Yongxia
authors.initials: Y
authors.lastname: Liu
authors.affiliation: College of Veterinary Medicine, Shandong Agricultural University, Tai'an, 271018, China. liujz@sdau.edu.cn.
authors.forename: Jianzhu
authors.initials: J
authors.lastname: Liu
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D002645:Chickens; D002712:Chlorides / Q000008:administration & dosage* / Q000494:pharmacology*; D017608:Chromium Compounds / Q000008:administration & dosage* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D013058:Mass Spectrometry; D014131:Trace Elements / Q000097:blood* / Q000378:metabolism*
chemical_list: D002712:Chlorides; D017608:Chromium Compounds; D014131:Trace Elements; C022990:chromic chloride
keywords: Blood–brain barrier; Chicken; Cr3+; Trace element