title: Association study of 5-HT1A, 5-HT2A polymorphisms with schizophrenia and major depressive disorder in the Han Chinese population.
abstract: Schizophrenia (SZ) and major depressive disorder (MDD) are two common severe mental disorders that have arisen to public awareness in recent years. Serotonin (5-HT) receptors have been implicated in the pathophysiology of psychiatric disorders especially in MDD and SZ. The aim of this study is to explore whether the variants in the 5-HT1A and 5-HT2A gene are susceptible to SZ or MDD in the Chinese Han population. Five SNPs (Single Nucleotide Polymorphisms) (rs1364043, rs10042486, rs6313, rs6311, rs17289304) in these genes were genotyped from 752 SZ patients, 568 MDD patients, and 846 normal controls of Chinese Han origin. The results showed that the 5-HT1A rs10042486 was significantly associated with SZ (Pallele=0.0369, Pgenotype=0.0098). Moreover, the haplotype (C-T) composed of rs10042486 and rs1364043 showed significant difference between SZ cases and healthy controls (P=0.0302) while another haplotype (T-G) was significant for MDD (P=0.0247). Our study is the first to suggest a positive association of the 5-HT1A gene with SZ in the Han Chinese population.
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Shanghai Key Laboratory of Psychiatric Disorders, Shanghai Mental Health Center, 600 South Wan Ping Road, Shanghai 200030, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Shanghai Key Laboratory of Psychiatric Disorders, Shanghai Mental Health Center, 600 South Wan Ping Road, Shanghai 200030, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Bi
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Shanghai Key Laboratory of Psychiatric Disorders, Shanghai Mental Health Center, 600 South Wan Ping Road, Shanghai 200030, China.
authors.forename: Weibo
authors.initials: W
authors.lastname: Niu
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Shanghai Key Laboratory of Psychiatric Disorders, Shanghai Mental Health Center, 600 South Wan Ping Road, Shanghai 200030, China.
authors.forename: Xiaoye
authors.initials: X
authors.lastname: Huang
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Shanghai Key Laboratory of Psychiatric Disorders, Shanghai Mental Health Center, 600 South Wan Ping Road, Shanghai 200030, China.
authors.forename: Shiqing
authors.initials: S
authors.lastname: Chen
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Shanghai Key Laboratory of Psychiatric Disorders, Shanghai Mental Health Center, 600 South Wan Ping Road, Shanghai 200030, China.
authors.forename: Xingwang
authors.initials: X
authors.lastname: Li
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Shanghai Key Laboratory of Psychiatric Disorders, Shanghai Mental Health Center, 600 South Wan Ping Road, Shanghai 200030, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Wu
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Shanghai Key Laboratory of Psychiatric Disorders, Shanghai Mental Health Center, 600 South Wan Ping Road, Shanghai 200030, China.
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Shanghai Key Laboratory of Psychiatric Disorders, Shanghai Mental Health Center, 600 South Wan Ping Road, Shanghai 200030, China.
authors.forename: Fengping
authors.initials: F
authors.lastname: Yang
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Shanghai Key Laboratory of Psychiatric Disorders, Shanghai Mental Health Center, 600 South Wan Ping Road, Shanghai 200030, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Shanghai Key Laboratory of Psychiatric Disorders, Shanghai Mental Health Center, 600 South Wan Ping Road, Shanghai 200030, China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Li
authors.affiliation: Shanghai Key Laboratory of Psychiatric Disorders, Shanghai Mental Health Center, 600 South Wan Ping Road, Shanghai 200030, China.
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Shanghai Key Laboratory of Psychiatric Disorders, Shanghai Mental Health Center, 600 South Wan Ping Road, Shanghai 200030, China.
authors.forename: Lin
authors.initials: L
authors.lastname: He
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Shanghai Key Laboratory of Psychiatric Disorders, Shanghai Mental Health Center, 600 South Wan Ping Road, Shanghai 200030, China. Electronic address: yutao@sjtu.edu.cn.
authors.forename: Tao
authors.initials: T
authors.lastname: Yu
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Shanghai Key Laboratory of Psychiatric Disorders, Shanghai Mental Health Center, 600 South Wan Ping Road, Shanghai 200030, China. Electronic address: heguang@sjtu.edu.cn.
authors.forename: Guang
authors.initials: G
authors.lastname: He
mesh_terms: D000328:Adult; D044466:Asian People; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics*; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D044282:Receptor, Serotonin, 5-HT1A
keywords: 5-HT1A; 5-HT2A; Association; Major depressive disorder; Schizophrenia