title: African Americans have lower TBS than whites among densitometry patients at a Chicago academic center.
abstract: Trabecular bone score, an indirect measure of bone structure, may differ between ethnicities. We found that African Americans had lower trabecular bone score than do whites referred for densitometry, even when controlling for age and abdominal soft tissue thickness.
  
  
  
  Trabecular bone score (TBS), an indirect measure of bone structure, has been shown to predict fractures in predominantly white populations. Analysis of NHANES data revealed lower TBS in African Americans than in whites. However, it is not clear if this is true in patients referred for densitometry (where fracture risk stratification is most pertinent) or if ethnic differences in TBS may be related to differences in abdominal soft tissue (tissue thickness), which was not controlled for in the NHANES study.
  
  
  
  We retrospectively analyzed all BMD scans obtained at a university hospital in Chicago between 2011 and 2016.
  
  
  
  There were 3187 women (51 % African American) and 675 men (32 % African American). African American women were older (69.6 ± 10.4 vs. 64.8 ± 1.3) and heavier (BMI 28.3 ± 4.7 vs. 25.4 ± 4.5) than whites were, while men were of similar age and BMI. African American women had higher T-scores at all sites (the lowest of T-scores, termed LowT, -1.5 ± 1.2 vs. -1.9 ± 1.0, p < 0.001) but lower TBS than white women even when adjusting for age and tissue thickness (1.231 ± 0.130 versus 1.251 ± 0.130, p < 0.001). While LowT was higher in African American men (-1.1 ± 1.2 vs. -1.5 ± 1.4, p < 0.001), TBS was lower than in white men even after adjusting for age and tissue thickness (1.232 ± 0.144 vs. 1.275 ± 0.144, p < 0.001).
  
  
  
  African Americans had lower TBS than whites did, even with adjustment for age and tissue thickness. Ethnic differences in TBS should be considered when assessing fracture risk in clinical practice.
authors.affiliation: Department of Endocrinology, Diabetes, and Metabolism, University of Chicago Medicine, 5841 S Maryland Ave AMB M267-MC1027, Chicago, IL, 60637, USA. rajesh.jain@uchospitals.edu.
authors.forename: R K
authors.initials: RK
authors.lastname: Jain
authors.affiliation: Department of Endocrinology, Diabetes, and Metabolism, University of Chicago Medicine, 5841 S Maryland Ave AMB M267-MC1027, Chicago, IL, 60637, USA.
authors.forename: T J
authors.initials: TJ
authors.lastname: Vokes
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D001741:Black or African American / Q000706:statistics & numerical data*; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D015519:Bone Density / Q000502:physiology*; D000071556:Cancellous Bone / Q000503:physiopathology*; D002641:Chicago / Q000453:epidemiology; D005260:Female; D005272:Femur Neck / Q000503:physiopathology; D006621:Hip Joint / Q000503:physiopathology; D006801:Humans; D008159:Lumbar Vertebrae / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000175:diagnosis / Q000208:ethnology* / Q000503:physiopathology; D012189:Retrospective Studies; D044465:White People / Q000706:statistics & numerical data*
keywords: African Americans; Ethnicity; Osteoporosis; Trabecular bone score