title: Silver(I)-Catalyzed Enantioselective [3+2]-Cycloaddition Reaction of α-Silylimines: A Facile Route to Quaternary-Carbon-Rich Scaffolds.
abstract: A silver-catalyzed highly enantioselective 1,3-dipolar cycloaddition reaction of α-silylimines with pyrone-based trisubstituted olefins was developed affording bi- and tricyclic α-quaternary-carbon-rich pyrano-pyrrolidines in excellent yields. The tricyclic benzopyrone adducts thus obtained were efficiently transformed into highly complex tetracyclic scaffolds supporting four consecutive stereogenic centers with three quaternary carbons.
authors.affiliation: Abteilung Chemische Biologie, Max-Planck-Institut für Molekulare Physiologie, Otto-Hahn-Straße 11, 44227, Dortmund, Germany.
authors.forename: Naredla
authors.initials: N
authors.lastname: Kesava-Reddy
authors.affiliation: Fakultät Chemie und Chemische Biologie, Technische Universität Dortmund, Otto-Hahn-Straße 6, 44221, Dortmund, Germany.
authors.forename: Christopher
authors.initials: C
authors.lastname: Golz
authors.affiliation: Fakultät Chemie und Chemische Biologie, Technische Universität Dortmund, Otto-Hahn-Straße 6, 44221, Dortmund, Germany.
authors.forename: Carsten
authors.initials: C
authors.lastname: Strohmann
authors.affiliation: Abteilung Chemische Biologie, Max-Planck-Institut für Molekulare Physiologie, Otto-Hahn-Straße 11, 44227, Dortmund, Germany.
authors.forename: Kamal
authors.identifier: http://orcid.org/0000-0003-3593-8421
authors.initials: K
authors.lastname: Kumar
keywords: asymmetric catalysis; azomethine ylides; cycloaddition; quaternary carbons; α-silyl imines