title: Biokinetic datasets of PEI F25-LMW complexed and non-complexed32P-siRNA within different lung compartments.
abstract: Biokinetics data of lung-administeredPEI F25-LMW/siRNA polyplexes within different lung compartments are presented. Thereby, at three different timepoints(1 h, 3 h, 8 h),the data was determined by calculationsto the32P-radioactivity in the whole mouse body. Additionally, data was optimized to the availablePEI F25-LMW/siRNA polyplexes in the target organ and therefore normalizedto the sum of all lung compartments. Methods, other biokinetics data and the discussion of the results are published in "Biokinetic studies of non-complexed siRNA versus nano-sized PEI F25-LMW/siRNA polyplexes following intratracheal instillation into mice" (Lipka et al., 2016 [1]).
authors.affiliation: Comprehensive Pneumology Center Institute of Lung Biology and Disease, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstaedter Landstraße 1, 85764 Neuherberg, Germany; Philipps-University of Marburg Department of Pharmaceutics and Biopharmacy, Ketzerbach 63, 35037 Marburg, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Lipka
authors.affiliation: Comprehensive Pneumology Center Institute of Lung Biology and Disease, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstaedter Landstraße 1, 85764 Neuherberg, Germany.
authors.forename: Manuela
authors.initials: M
authors.lastname: Semmler-Behnke
authors.affiliation: Comprehensive Pneumology Center Institute of Lung Biology and Disease, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstaedter Landstraße 1, 85764 Neuherberg, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Wenk
authors.affiliation: Fraunhofer Institute for Cell Therapy and Immunology (IZI) Leipzig, Perlickstraße 1, 04103 Leipzig, Germany.
authors.forename: Jana
authors.initials: J
authors.lastname: Burkhardt
authors.affiliation: Rudolf-Boehm-Institute for Pharmacology and Toxicology, Clinical Pharmacology University of Leipzig, Haertelstrasse 16-18, 04107 Leipzig, Germany.
authors.forename: Achim
authors.initials: A
authors.lastname: Aigner
authors.affiliation: Comprehensive Pneumology Center Institute of Lung Biology and Disease, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstaedter Landstraße 1, 85764 Neuherberg, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Kreyling
keywords: Biokinetic data; Lung; PEI