title: Vascular Transdifferentiation in the CNS: A Focus on Neural and Glioblastoma Stem-Like Cells.
abstract: Glioblastomas are devastating and extensively vascularized brain tumors from which glioblastoma stem-like cells (GSCs) have been isolated by many groups. These cells have a high tumorigenic potential and the capacity to generate heterogeneous phenotypes. There is growing evidence to support the possibility that these cells are derived from the accumulation of mutations in adult neural stem cells (NSCs) as well as in oligodendrocyte progenitors. It was recently reported that GSCs could transdifferentiate into endothelial-like and pericyte-like cells bothin vitroandin vivo, notably under the influence of Notch and TGFβsignaling pathways. Vascular cells derived from GBM cells were also observed directly in patient samples. These results could lead to new directions for designing original therapeutic approaches against GBM neovascularization but this specific reprogramming requires further molecular investigations. Transdifferentiation of nontumoral neural stem cells into vascular cells has also been described and conversely vascular cells may generate neural stem cells. In this review, we present and discuss these recent data. As some of them appear controversial, further validation will be needed using new technical approaches such as high throughput profiling and functional analyses to avoid experimental pitfalls and misinterpretations.
authors.affiliation: INSERM U1051, Institut des Neurosciences de Montpellier, Hôpital St Eloi, 80 Avenue Augustin Fliche, 34091 Montpellier Cedex 05, France; Université Montpellier 2, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France.
authors.forename: Sophie
authors.identifier: 0000-0002-3579-4969
authors.initials: S
authors.lastname: Guelfi
authors.affiliation: INSERM U1051, Institut des Neurosciences de Montpellier, Hôpital St Eloi, 80 Avenue Augustin Fliche, 34091 Montpellier Cedex 05, France; CHU Montpellier, Hôpital Gui de Chauliac, 80 Avenue Augustin Fliche, 34295 Montpellier, France.
authors.forename: Hugues
authors.identifier: 0000-0002-6558-2342
authors.initials: H
authors.lastname: Duffau
authors.affiliation: INSERM U1051, Institut des Neurosciences de Montpellier, Hôpital St Eloi, 80 Avenue Augustin Fliche, 34091 Montpellier Cedex 05, France; CHU Montpellier, Hôpital Gui de Chauliac, 80 Avenue Augustin Fliche, 34295 Montpellier, France.
authors.forename: Luc
authors.initials: L
authors.lastname: Bauchet
authors.affiliation: INSERM U1051, Institut des Neurosciences de Montpellier, Hôpital St Eloi, 80 Avenue Augustin Fliche, 34091 Montpellier Cedex 05, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Rothhut
authors.affiliation: INSERM U1051, Institut des Neurosciences de Montpellier, Hôpital St Eloi, 80 Avenue Augustin Fliche, 34091 Montpellier Cedex 05, France; Université Montpellier 2, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Hugnot