title: miRNAs and their role in the correlation between schizophrenia and cancer (Review).
abstract: Schizophrenia (SZ) and cancer (Ca) have a broad spectrum of clinical phenotypes and a complex biological background, implicating a large number of genetic and epigenetic factors. SZ is a chronic neurodevelopmental disorder signified by an increase in the expression of apoptotic molecular signals, whereas Ca is conversely characterized by an increase in appropriate molecular signaling that stimulates uncontrolled cell proliferation. The rather low risk of developing Ca in patients suffering from SZ is a hypothesis that is still under debate. Recent evidence has indicated that microRNAs (miRNAs or miRs), a large group of small non‑coding oligonoucleotides, may play a significant role in the development of Ca and major psychiatric disorders, such as SZ, bipolar disorder, autism spectrum disorders, suicidality and depression, through their interference with the expression of multiple genes. For instance, the possible role of let‑7, miR‑98 and miR‑183 as biomarkers for Ca and SZ was investigated in our previous research studies. Therefore, further investigations on the expression profiles of these regulatory, small RNA molecules and the molecular pathways through which they exert their control may provide a plausible explanation as to whether there is a correlation between psychiatric disorders and low risk of developing Ca.
authors.affiliation: 2nd Department of Psychiatry, National and Kapodistrian University of Athens, School of Medicine, University General Hospital 'ATTIKON', Athens 124 62, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Rizos
authors.affiliation: Laboratory of Clinical Microbiology, National and Kapodistrian University of Athens, School of Medicine, University General Hospital 'ATTIKON', Athens 124 62, Greece.
authors.forename: N
authors.initials: N
authors.lastname: Siafakas
authors.affiliation: Unit of Biomedical Applications, Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, Athens 116 35, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Skourti
authors.affiliation: 1st Department of Psychiatry, National and Kapodistrian University of Athens, School of Medicine, 'Eginition' Hospital, Athens 115 28, Greece.
authors.forename: C
authors.initials: C
authors.lastname: Papageorgiou
authors.affiliation: Keenan Research Centre, Li Ka Shing Knowledge Centre, Institute of Biomedical Science, St. Michael's Hospital, Toronto, ON M5B 1W8, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Tsoporis
authors.affiliation: Keenan Research Centre, Li Ka Shing Knowledge Centre, Institute of Biomedical Science, St. Michael's Hospital, Toronto, ON M5B 1W8, Canada.
authors.forename: T H
authors.initials: TH
authors.lastname: Parker
authors.affiliation: Unit of Biomedical Applications, Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, Athens 116 35, Greece.
authors.forename: D I
authors.initials: DI
authors.lastname: Christodoulou
authors.affiliation: Laboratory of Clinical Virology, Medical School, University of Crete, Heraklion 71003, Greece.
authors.forename: D A
authors.initials: DA
authors.lastname: Spandidos
authors.affiliation: Biomedical Research Foundation, Academy of Athens, Hematology‑Oncology Division, Athens 115 27, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Katsantoni
authors.affiliation: Unit of Biomedical Applications, Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, Athens 116 35, Greece.
authors.forename: V
authors.initials: V
authors.lastname: Zoumpourlis
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D035683:MicroRNAs