title: Implications and Assessment of the Elastic Behavior of Lamins in Laminopathies.
abstract: Lamins are mechanosensitive and elastic components of the nuclear lamina that respond to external mechanical cues by altering gene regulation in a feedback mechanism. Numerous mutations in A-type lamins cause a plethora of diverse diseases collectively termed as laminopathies, the majority of which are characterized by irregularly shaped, fragile, and plastic nuclei. These nuclei are challenged to normal mechanotransduction and lead to disease phenotypes. Here, we review our current understanding of the nucleocytoskeleton coupling in mechanotransduction mediated by lamins. We also present an up-to-date understanding of the methods used to determine laminar elasticity both at the bulk and single molecule level.
authors.affiliation: Biophysics & Structural Genomics Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064, West Bengal, India. suborna.dutta@gmail.com.|Department of Biochemistry, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700019, West Bengal, India. suborna.dutta@gmail.com.
authors.forename: Subarna
authors.initials: S
authors.lastname: Dutta
authors.affiliation: Department of Biochemistry, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700019, West Bengal, India. bmaitree@gmail.com.
authors.forename: Maitree
authors.initials: M
authors.lastname: Bhattacharyya
authors.affiliation: Biophysics & Structural Genomics Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064, West Bengal, India. kaushik.sengupta@saha.ac.in.
authors.forename: Kaushik
authors.initials: K
authors.lastname: Sengupta
keywords: elasticity; lamins; mechanotransduction; single molecule force spectroscopy