title: Dissolution rate improvement of telmisartan through modified MCC pellets using 32full factorial design.
abstract: Context:Microcrystalline cellulose (MCC) is the most widely used excipient for the production of pellets but it retards the release of poorly water soluble drugs.Objective:The present investigation reports incorporation of camphor, cross carmellose sodium (CCS) and spray dried lactose (SDL) into MCC pellets to enhance the dissolution rate of telmisartan.Materials and methods:A full factorial design (32) was used in the study. Concentration of camphor and CCS was selected as independent variables whereas percentage porosity and percentage drug release at 60 min were selected as dependent variables. Pellets were produced by extrusion-spheronization technique and evaluated for percentage yield, particle size analysis, flow characteristics, percentage porosity, drug content andin vitrodrug release. Contour plots and 3-D surface plots were presented for graphical expression of the results.Results and discussion:Pellet formulations exhibited acceptable morphological, flow and mechanical properties. As against to 38.54% drug release after 60 min with MCC pellets, pellets prepared with optimized formulation, composed of proper combination of MCC, SDL, camphor and CCS, released 100% drug after 60 min.Conclusion:Our study underlines the fact that dissolution of telmisartan from MCC pellets can be successfully enhanced by incorporating water soluble excipient, disintegrant and pore formers.
authors.affiliation: Maliba Pharmacy College, Uka Tarsadia University, Bardoli Mahuva Road, Surat, Gujarat 394 350, India.
authors.forename: Hetal
authors.initials: H
authors.lastname: Patel
authors.affiliation: Maliba Pharmacy College, Uka Tarsadia University, Bardoli Mahuva Road, Surat, Gujarat 394 350, India.
authors.forename: Hiral
authors.initials: H
authors.lastname: Patel
authors.affiliation: Anand Pharmacy College, Gujarat, India.
authors.forename: Mukesh
authors.initials: M
authors.lastname: Gohel
authors.affiliation: Maliba Pharmacy College, Uka Tarsadia University, Bardoli Mahuva Road, Surat, Gujarat 394 350, India.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Tiwari
keywords: Camphor; Crosscarmellose sodium; Factorial design; Microcrystalline cellulose; Spray dried lactose