title: TLR7 Structure: Cut in Z-Loop.
abstract: TLRs play central roles in host defense. In this issue of Immunity, Zhang et al. (2016) generate structures of TLR7 bound to multiple ligands and provide insight into the mechanism of TLR7 ligand recognition that highlights the differences in the features of the TLR subfamily.
authors.affiliation: Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan; Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Maeda
authors.affiliation: Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan; Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan. Electronic address: sakira@biken.osaka-u.ac.jp.
authors.forename: Shizuo
authors.initials: S
authors.lastname: Akira
mesh_terms: D000818:Animals; D007109:Immunity / Q000276:immunology; D008024:Ligands; D012313:RNA / Q000378:metabolism; D051199:Toll-Like Receptor 7 / Q000737:chemistry / Q000276:immunology / Q000378:metabolism
chemical_list: D008024:Ligands; D012313:RNA; D051199:Toll-Like Receptor 7