title: Relationship between hepatitis B virus infection and chronic kidney disease in Asian populations: a meta-analysis.
abstract: OBJECTIVE
  To evaluate the association of Chronic hepatitis B virus (HBV) infection and chronic kidney disease (CKD).
  
  
  METHODS
  We searched Embase, Grateful Med, Ovid, PubMed, and the China Biological Medicine Database. A meta-analysis was performed to assess whether HBV infection plays an independent impact on the development of CKD in the general population. Relative risks of CKD (defined as reduced glomerular filtration rate or proteinuria) according to HBsAg serologic status were studied.
  
  
  RESULTS
  Six eligible clinical studies (189,709 individuals in total) were included in the analysis. There was no association between HBsAg seropositive status and prevalence of CKD, the summary estimate for adjusted relative risk (RR) was 1.16 (95% confidence interval (CI), 0.78, 1.71; p = .46) according to the random-effects model, and between studies heterogeneity was noted (p values by Q test <0.001). Also, there were no significant associations between positive HBV serologic status and low eGFR (adjusted relative risk, 0.95; 95% CI, 0.72, 1.26; p = .72) or proteinuria (adjusted relative risk, 1.00; 95% CI, 0.83, 1.20; p = .99).
  
  
  CONCLUSIONS
  This meta-analysis shows that there was no association between exposure to HBV and the risk of developing CKD in Asian populations.
authors.affiliation: a Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases , The Second Affiliated Hospital, Chongqing Medical University , Chongqing , PR China.
authors.forename: Qing-Chun
authors.initials: QC
authors.lastname: Cai
authors.affiliation: a Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases , The Second Affiliated Hospital, Chongqing Medical University , Chongqing , PR China.
authors.forename: Shu-Qi
authors.initials: SQ
authors.lastname: Zhao
authors.affiliation: a Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases , The Second Affiliated Hospital, Chongqing Medical University , Chongqing , PR China.
authors.forename: Tong-Dong
authors.initials: TD
authors.lastname: Shi
authors.affiliation: a Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases , The Second Affiliated Hospital, Chongqing Medical University , Chongqing , PR China.
authors.forename: Hong
authors.initials: H
authors.lastname: Ren
mesh_terms: D001208:Asia / Q000453:epidemiology; D044466:Asian People; D005919:Glomerular Filtration Rate; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D019694:Hepatitis B, Chronic / Q000453:epidemiology*; D006801:Humans; D011507:Proteinuria / Q000453:epidemiology; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology* / Q000821:virology; D018570:Risk Assessment
chemical_list: D006514:Hepatitis B Surface Antigens
keywords: Hepatitis B; glomerular filtration rate; kidney disease; proteinuria