title: Synthesis of stable isotope labeled D9-Mabuterol, D9-Bambuterol, and D9-Cimbuterol.
abstract: Three stable and simple synthetic routes of labeled D9-Mabuterol, D9-Bambuterol, and D9-Cimbuterol were described with 98.5%, 99.7%, and 98.4% isotopic abundance and good purity. These structures and isotope-abundance were confirmed according to1H NMR and liquid chromatography-tandem mass spectrometry.
authors.affiliation: Research and Development Center, Shanghai Research Institute of Chemical Industry, Shanghai, China.
authors.forename: Yahui
authors.initials: Y
authors.lastname: Tu
authors.affiliation: Research and Development Center, Shanghai Research Institute of Chemical Industry, Shanghai, China.
authors.forename: Jiaqi
authors.initials: J
authors.lastname: Zhong
authors.affiliation: Research and Development Center, Shanghai Research Institute of Chemical Industry, Shanghai, China.
authors.forename: Haoran
authors.initials: H
authors.lastname: Wang
authors.affiliation: Research and Development Center, Shanghai Research Institute of Chemical Industry, Shanghai, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Pan
authors.affiliation: Research and Development Center, Shanghai Research Institute of Chemical Industry, Shanghai, China.
authors.forename: Zhongjie
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Research and Development Center, Shanghai Research Institute of Chemical Industry, Shanghai, China.
authors.forename: Weicheng
authors.initials: W
authors.lastname: Yang
authors.affiliation: Research and Development Center, Shanghai Research Institute of Chemical Industry, Shanghai, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Luo
mesh_terms: D015078:2-Hydroxyphenethylamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D002976:Clenbuterol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D003903:Deuterium / Q000737:chemistry*; D007553:Isotope Labeling; D013726:Terbutaline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000814:Aniline Compounds; C583263:cimbuterol; D015078:2-Hydroxyphenethylamine; D003903:Deuterium; D013726:Terbutaline; C044573:mabuterol; D002976:Clenbuterol; C047766:bambuterol
keywords: internal standards; isotope labeling; synthesis; β-agonist