title: Repeated measures analysis of associations between urinary bisphenol-A concentrations and biomarkers of inflammation and oxidative stress in pregnancy.
abstract: Bisphenol-A (BPA) exposure occurs commonly and may adversely impact pregnancy. Endocrine disruption is posited as the primary mechanism of action, but oxidative stress and inflammation pathways may also be important. We investigated associations between BPA exposure and oxidative stress and inflammation in 482 pregnant women. Participants were recruited early in pregnancy and provided urine and plasma at up to four visits. We measured total BPA and two biomarkers of oxidative stress (8-hydroxydeoxyguanosine and 8-isoprostane) in urine from each visit. Inflammation markers, including C-reactive protein and four cytokines were measured in plasma from the same time points. In adjusted models, an interquartile range increase in BPA was associated with significant increases in both oxidative stress biomarkers (5-9% increase). Additionally, we observed significantly higher IL-6 concentrations in association with an interquartile range increase in BPA (8.95% increase). These systemic changes consequent to BPA exposure may mediate adverse birth outcomes and/or fetal development.
authors.affiliation: Epidemiology Branch, National Institute of Environmental Health Sciences, 111 TW Alexander Drive, Research Triangle Park, NC, USA; Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI, USA.
authors.forename: Kelly K
authors.initials: KK
authors.lastname: Ferguson
authors.affiliation: Divison of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, USA.
authors.forename: David E
authors.initials: DE
authors.lastname: Cantonwine
authors.affiliation: Divison of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, USA.
authors.forename: Thomas F
authors.initials: TF
authors.lastname: McElrath
authors.affiliation: Department of Biostatistics, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI, USA.
authors.forename: Bhramar
authors.initials: B
authors.lastname: Mukherjee
authors.affiliation: Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI, USA. Electronic address: meekerj@umich.edu.
authors.forename: John D
authors.initials: JD
authors.lastname: Meeker
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D001559:Benzhydryl Compounds / Q000652:urine*; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002097:C-Reactive Protein / Q000032:analysis; D016207:Cytokines / Q000097:blood; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D015237:Dinoprost / Q000031:analogs & derivatives / Q000652:urine; D052244:Endocrine Disruptors / Q000652:urine*; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000652:urine*; D005260:Female; D005333:Fetus; D006801:Humans; D007249:Inflammation / Q000652:urine; D008297:Male; D018384:Oxidative Stress; D010636:Phenols / Q000652:urine*; D011247:Pregnancy / Q000097:blood / Q000652:urine*; D000098826:Bisphenol A Compounds
chemical_list: D000080242:8-Hydroxy-2'-Deoxyguanosine; D001559:Benzhydryl Compounds; D015415:Biomarkers; D002097:C-Reactive Protein; D016207:Cytokines; D003849:Deoxyguanosine; D015237:Dinoprost; D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D010636:Phenols; C075750:8-epi-prostaglandin F2alpha; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: BPA; Biomarkers; IL-6; Inflammation; Longitudinal; Oxidative stress; Pregnancy