title: Evaluation of new chlorhexidine- and cetylpyridinium chloride-based mouthrinse formulations adjunctive to scaling and root planing: pilot study.
abstract: OBJECTIVE
  To compare the effect of two newly formulated chlorhexidine (CHX) and cetylpyridinium chloride (CPC) mouthrinses after scaling and root planing (SRP) in terms of clinical, microbiological, patient-based variables and adverse events, with a positive control with the same active components, already marketed and tested.
  
  
  METHODS
  A pilot, randomized clinical trial, double-blind, parallel design with 1-month follow-up was conducted. Chronic periodontitis patients requiring non-surgical periodontal therapy were enrolled and randomly assigned to: (i) SRP and test-1 (new reformulation: 0.12% CHX and 0.05% CPC); (ii) SRP and test-2 (new formulation: 0.03% CHX and 0.05% CPC); or (iii) SRP and positive control (commercial product: 0.12% CHX and 0.05% CPC). All variables were evaluated at baseline and 1 month after SRP. Quantitative variables were compared by means of anova or Kruskal-Wallis test and qualitative variables by chi-square or McNemar tests.
  
  
  RESULTS
  Thirty patients (10 per group) were included. After 1 month, there were significant differences among groups in plaque levels (P = 0.016) as test-1 showed less sites with plaque than test-2 (31.15% [standard error-SE 2.21%] versus 49.39% [SE 4.60%), respectively). No significant differences were found for global patient perception of the product or in adverse effects. Test groups showed better results in levels and proportions (P = 0.022) of Capnocytophaga spp.
  
  
  CONCLUSIONS
  Within the limitations of this pilot study, it can be concluded that the newly formulated 0.12% CHX and 0.05% CPC mouthrinse showed larger plaque level reductions, without showing more adverse effects, when compared to the other two mouthrinses, after SRP.
authors.affiliation: Section of Graduate Periodontology, Faculty of Odontology, University Complutense, Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: García-Gargallo
authors.affiliation: Section of Graduate Periodontology, Faculty of Odontology, University Complutense, Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Zurlohe
authors.affiliation: Section of Graduate Periodontology, Faculty of Odontology, University Complutense, Madrid, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Montero
authors.affiliation: Etiology and Therapy of Periodontal Diseases (ETEP) Research Group, Faculty of Odontology, University Complutense, Madrid, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Alonso
authors.affiliation: Etiology and Therapy of Periodontal Diseases (ETEP) Research Group, Faculty of Odontology, University Complutense, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Serrano
authors.affiliation: Etiology and Therapy of Periodontal Diseases (ETEP) Research Group, Faculty of Odontology, University Complutense, Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Sanz
authors.affiliation: Etiology and Therapy of Periodontal Diseases (ETEP) Research Group, Faculty of Odontology, University Complutense, Madrid, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Herrera
mesh_terms: D000328:Adult; D000368:Aged; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002594:Cetylpyridinium / Q000627:therapeutic use*; D002710:Chlorhexidine / Q000627:therapeutic use*; D055113:Chronic Periodontitis / Q000382:microbiology / Q000517:prevention & control*; D003773:Dental Plaque / Q000382:microbiology / Q000517:prevention & control*; D012534:Dental Scaling; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000627:therapeutic use*; D010865:Pilot Projects; D016745:Root Planing; D016896:Treatment Outcome
chemical_list: D000891:Anti-Infective Agents, Local; D009067:Mouthwashes; D002594:Cetylpyridinium; D002710:Chlorhexidine
keywords: antiseptics; cetylpyridinium chloride; chlorhexidine; dental plaque; mouthrinse; non-surgical periodontal therapy; scaling and root planing