title: Role of Adipose-derived Stem Cells in Fat Grafting and Reconstructive Surgery.
abstract: Autologous fat grafting is commonly utilised to reconstruct soft tissue defects caused by ageing, trauma, chronic wounds and cancer resection. The benefits of fat grafting are minimal donor site morbidity and ease of availability through liposuction or lipectomy. Nonetheless, survival and longevity of fat grafts remain poor post-engraftment. Various methods to enhance fat graft survival are currently under investigation and its stem cell constituents are of particular interest. Cell-assisted lipotransfer refers to the addition of adipose-derived stem cell (ASC) rich component of stromal vascular fraction to lipoaspirate, the results of which have proven promising. This article aims to review the role of ASCs in fat grafting and reconstructive surgery.
authors.affiliation: Royal College of Physicians and Surgeons of Glasgow, Glasgow G2 5RJ, UK.
authors.forename: Shaun S
authors.initials: SS
authors.lastname: Tan
authors.affiliation: Royal College of Physicians and Surgeons of Glasgow, Glasgow G2 5RJ, UK.
authors.forename: Zhi Yang
authors.initials: ZY
authors.lastname: Ng
authors.affiliation: Department of Plastic and Reconstructive Surgery, Nanfang Hospital, Southern Medical University, China.
authors.forename: Weiqing
authors.initials: W
authors.lastname: Zhan
authors.affiliation: Department of Surgery, Monash University, Clayton, VIC, Australia.
authors.forename: Warren
authors.initials: W
authors.lastname: Rozen
keywords: Adipose-derived stem cell; liposuction; mesenchymal stem cell; reconstruction