title: Metal-Organic Framework-Polymer Composite as a Highly Efficient Sorbent for Sulfonamide Adsorption and Desorption: Effect of Coordinatively Unsaturated Metal Site and Topology.
abstract: In this study, we first demonstrated the effect of two types of metal-organic framework-polymer (MOF-polymer) monoliths on in-tube solid-phase microextraction (IT-SPME) of sulfonamides. Sulfonamides were successfully adsorbed onto MIL-101(Cr)-polymer but were difficult to elute due to these sulfonamides could interact via Lewis acid-base interaction with the presence of Cr(III) coordinatively unsaturated metal sites (CUS). Moreover, the cage-type topology of MIL-101(Cr) that could produce multiple pathways thus complicates the desorption of the test analytes from the sorbent. Contrastingly, MIL-53(Al)-polymer provided weaker Al(III) CUS, and its one-dimensional channel pore structure could provide an unhindered pathway for sulfonamides transfer during elution. After optimizing the IT-SPME condition such as MOF content, pH of sample matrix, column length, extraction flow rate, and elution volume, the calculated extraction recovery of sulfonamides in MIL-53(Al)-polymer as analyzed by microemulsion electrokinetic chromatography (MEEKC) were in the range of 40%-90% with relative standard deviations (RSDs) below 5% and a reusability of at least 30 times.
authors.affiliation: Department of Chemistry, Chung Yuan Christian University 200 Chung Pei Road, Chung Li District, Taoyuan City, 320, Taiwan, R.O.C.
authors.forename: Yung-Han
authors.initials: YH
authors.lastname: Shih
authors.affiliation: Department of Chemistry, Chung Yuan Christian University 200 Chung Pei Road, Chung Li District, Taoyuan City, 320, Taiwan, R.O.C.
authors.forename: Kuen-Yun
authors.initials: KY
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Chung Yuan Christian University 200 Chung Pei Road, Chung Li District, Taoyuan City, 320, Taiwan, R.O.C.
authors.forename: Brenda
authors.initials: B
authors.lastname: Singco
authors.affiliation: Department of Chemistry, Chung Yuan Christian University 200 Chung Pei Road, Chung Li District, Taoyuan City, 320, Taiwan, R.O.C.
authors.forename: Chia-Her
authors.initials: CH
authors.lastname: Lin
authors.affiliation: Department of Chemistry, Chung Yuan Christian University 200 Chung Pei Road, Chung Li District, Taoyuan City, 320, Taiwan, R.O.C.
authors.forename: Hsi-Ya
authors.initials: HY
authors.lastname: Huang