title: Acute effect of iloprost inhalation on right atrial function and ventricular dyssynchrony in patients with pulmonary artery hypertension.
abstract: BACKGROUND
  Right atrium function and ventricular function have significant prognostic value in pulmonary arterial hypertension patients. Acute changes in right ventricular synchrony and right atrium function postiloprost inhalation have not been evaluated.
  
  
  METHODS
  Cross-sectional study. Consecutive pulmonary arterial hypertension patients (group I from Nice classification) were included. Echocardiographic right atrium and right ventricular function pre- and postiloprost inhalation, including a right ventricular dyssynchrony index and right atrium function using speckle tracking, were performed in all patients.
  
  
  RESULTS
  Twenty pulmonary arterial hypertension patients, 44±7 years and 90% females, were included. After iloprost inhalation, we observed a significant increment in right ventricular fractional area change and a significant decrease in right ventricular dyssynchrony index (21.4±5.6% vs 26.1±4.0 %, P=.007 and 79±44 vs 32±22 mseconds, P<.01, respectively), also an improvement in right atrium reservoir function (8.6±3.1% vs 11.7±3.5 %, P=.002).
  
  
  CONCLUSIONS
  Iloprost inhalation induces acute changes in right ventricular function, dyssynchrony, and right atrium performance that may add relevant clinical information in the management and risk stratification of pulmonary arterial hypertension patients.
authors.affiliation: Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Pontificia Universidad Católica, Santiago, Chile.|Division of Cardiovascular Diseases, Faculty of Medicine, Pontificia Universidad Católica, Santiago, Chile.
authors.forename: Luigi
authors.initials: L
authors.lastname: Gabrielli
authors.affiliation: Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Pontificia Universidad Católica, Santiago, Chile.|Division of Cardiovascular Diseases, Faculty of Medicine, Pontificia Universidad Católica, Santiago, Chile.
authors.forename: María Paz
authors.initials: MP
authors.lastname: Ocaranza
authors.affiliation: Institute Clinic Cardiovascular, Hospital Clínic of Barcelona, IDIBAPS, August Pi i Sunyer Biomedical Research Institute, University of Barcelona, Barcelona, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Sitges
authors.affiliation: Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Pontificia Universidad Católica, Santiago, Chile.|Division of Cardiovascular Diseases, Faculty of Medicine, Pontificia Universidad Católica, Santiago, Chile.
authors.forename: Andrés
authors.initials: A
authors.lastname: Kanacri
authors.affiliation: Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Pontificia Universidad Católica, Santiago, Chile.|Division of Cardiovascular Diseases, Faculty of Medicine, Pontificia Universidad Católica, Santiago, Chile.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Saavedra
authors.affiliation: Clinic Hospital, Faculty of Medicine, University of Santiago, Santiago, Chile.
authors.forename: Pablo
authors.initials: P
authors.lastname: Sepulveda
authors.affiliation: Salvador Hospital, Faculty of Medicine, University of Chile, Santiago, Chile.
authors.forename: Luis
authors.initials: L
authors.lastname: Sepulveda
authors.affiliation: Clinic Hospital, Faculty of Medicine, University of Santiago, Santiago, Chile.
authors.forename: Victor
authors.initials: V
authors.lastname: Rossel
authors.affiliation: National Institute of Thorax, Santiago, Chile.
authors.forename: Monica
authors.initials: M
authors.lastname: Zagolin
authors.affiliation: Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Pontificia Universidad Católica, Santiago, Chile.|Division of Cardiovascular Diseases, Faculty of Medicine, Pontificia Universidad Católica, Santiago, Chile.
authors.forename: Hugo E
authors.initials: HE
authors.lastname: Verdejo
authors.affiliation: Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Pontificia Universidad Católica, Santiago, Chile.|Division of Cardiovascular Diseases, Faculty of Medicine, Pontificia Universidad Católica, Santiago, Chile.
authors.forename: Fernando
authors.initials: F
authors.lastname: Baraona
authors.affiliation: Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Pontificia Universidad Católica, Santiago, Chile.|Division of Cardiovascular Diseases, Faculty of Medicine, Pontificia Universidad Católica, Santiago, Chile.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Zalaquett
authors.affiliation: Advanced Center for Chronic Diseases (ACCDiS) & Molecular Studies of the Cell (CEMC), Faculty of Chemical and Pharmaceutical Sciences & Faculty of Medicine, University of Chile, Santiago, Chile.|Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
authors.forename: Mario
authors.initials: M
authors.lastname: Chiong
authors.affiliation: Advanced Center for Chronic Diseases (ACCDiS) & Molecular Studies of the Cell (CEMC), Faculty of Chemical and Pharmaceutical Sciences & Faculty of Medicine, University of Chile, Santiago, Chile.|Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
authors.forename: Sergio
authors.initials: S
authors.lastname: Lavandero
authors.affiliation: Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Pontificia Universidad Católica, Santiago, Chile.|Division of Cardiovascular Diseases, Faculty of Medicine, Pontificia Universidad Católica, Santiago, Chile.
authors.forename: Pablo F
authors.initials: PF
authors.lastname: Castro
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D016280:Atrial Function, Right / Q000187:drug effects* / Q000502:physiology; D003430:Cross-Sectional Studies; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D016285:Iloprost / Q000008:administration & dosage*; D008297:Male; D011651:Pulmonary Artery / Q000187:drug effects / Q000503:physiopathology; D012189:Retrospective Studies; D014665:Vasodilator Agents / Q000008:administration & dosage; D016278:Ventricular Function, Right / Q000187:drug effects / Q000502:physiology
chemical_list: D014665:Vasodilator Agents; D016285:Iloprost
keywords: pulmonary hypertension; right atrium; right ventricular function