title: Distinctive roles of PKC delta isozyme in platelet function.
abstract: Platelet activation is a complex balance of positive and negative signaling pathways. Several protein kinase C (PKC) isoforms are expressed in human platelets. They are a major regulator of platelet granule secretion, activation and aggregation activity. One of those isoforms is the PKCδ isozyme, it has a central yet complex role in platelets such as opposite signaling functions depending on the nature of the agonist, it concentration and pathway. In fact, it has been shown that PKCδ has an overall negative influence on platelet function in response to collagen, while, following PAR stimulation, PKCδ has a positive effect on platelet function. Understanding the crucial role of PKCδ in platelet functions is recently emerging in the literature, therefore, further investigations should shed light into its specific role in hemostasis. In this review, we focus on the different roles of PKCδ in platelet activation, aggregation and thrombus formation.
authors.affiliation: Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada. Electronic address: younes_zaid@yahoo.ca.
authors.forename: Y
authors.initials: Y
authors.lastname: Zaid
authors.affiliation: Laboratory of Genetics and Molecular Pathologies (LGPM), Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco. Electronic address: nezha.senhaji@gmail.com.
authors.forename: N
authors.initials: N
authors.lastname: Senhaji
authors.affiliation: Laboratory of Physiology and Molecular Genetics, Faculty of Sciences, Hassan II University, Casablanca, Morocco. Electronic address: darifyoussef2000@yahoo.fr.
authors.forename: Y
authors.initials: Y
authors.lastname: Darif
authors.affiliation: Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada. Electronic address: kevinkojok@outlook.com.
authors.forename: K
authors.initials: K
authors.lastname: Kojok
authors.affiliation: Laboratory of Physiology and Molecular Genetics, Faculty of Sciences, Hassan II University, Casablanca, Morocco. Electronic address: mouniaoudghiri@gmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Oudghiri
authors.affiliation: Laboratory of Physiology and Molecular Genetics, Faculty of Sciences, Hassan II University, Casablanca, Morocco. Electronic address: anaya@mabiotech.com.
authors.forename: A
authors.initials: A
authors.lastname: Naya
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000502:physiology*; D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology* / Q000502:physiology; D003094:Collagen / Q000494:pharmacology; D003594:Cytoplasmic Granules / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes / Q000097:blood / Q000737:chemistry / Q000502:physiology; D051379:Mice; D010766:Phosphorylation; D015539:Platelet Activation / Q000187:drug effects / Q000502:physiology*; D010980:Platelet Membrane Glycoproteins / Q000378:metabolism; D011487:Protein Conformation; D000072417:Protein Domains; D051745:Protein Kinase C-delta / Q000097:blood / Q000737:chemistry / Q000502:physiology*; D011499:Protein Processing, Post-Translational; D021381:Protein Transport; D011554:Pseudopodia / Q000648:ultrastructure; D044462:Receptors, Proteinase-Activated / Q000097:blood; D015398:Signal Transduction; D013917:Thrombin / Q000494:pharmacology
chemical_list: D007527:Isoenzymes; D010980:Platelet Membrane Glycoproteins; D044462:Receptors, Proteinase-Activated; D003094:Collagen; D051745:Protein Kinase C-delta; D013917:Thrombin
keywords: PKC delta; Platelets; Thrombosis