title: Anti-biofilm properties of bioactive glasses embedding organic active compounds.
abstract: Bioactive glasses (BGs) are promising materials for bone repair due to their desirable properties such as osteoconductivity, biodegradability, angiogenic potential, and antibacterial activity. Ionic dissolution products from bioactive glasses increase the medium pH inhibiting surrounding bacteria proliferation. The activity of BGs against biofilm formation has been enhanced by incorporating organic antibacterial compounds. The aim of this review was to summarize evidence in literature which assesses the efficacy of antibacterial and anti-biofilm compounds embedded in bioactive glasses to prevent peri-implant infection during bone healing. A PubMed bibliographical research was carried out including articles published in the last 20 years. Most previous studies evaluated antibacterial efficiency in planktonic cultures but did not investigate biofilm inhibition, underestimating biofilm clinical relevance. Multifactorial features such as biocompatibility of embedded compounds, receptor site characteristics, and drug delivery efficiency have been found to influence the bioactive glass capability of acting both as an anti-biofilm agent and as a bone repairing biomaterial. Accordingly, further in vitro and in vivo studies are required to select the most promising anti-biofilm agents which should be incorporated into bioactive glasses to counteract biofilm proliferation, without inducing toxic effects on human cells, and with the added functionality of promoting bone regeneration. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 672-679, 2017.
authors.affiliation: Department of Dentistry (ODT), Center for Education and Research on Dental Implants (CEPID), Post-Graduate Program in Dentistry (PPGO), Federal University of Santa Catarina(UFSC), Florianópolis/SC, 88040-900, Brazil.
authors.forename: M E
authors.initials: ME
authors.lastname: Galarraga-Vinueza
authors.affiliation: Department of Mechanical Engineering (EMC), Ceramic and Composite Materials Research Group (CERMAT), Federal University of Santa Catarina, Florianópolis, 88040-900, Brazil.
authors.forename: J
authors.initials: J
authors.lastname: Mesquita-Guimarães
authors.affiliation: Department of Dentistry (ODT), Center for Education and Research on Dental Implants (CEPID), Post-Graduate Program in Dentistry (PPGO), Federal University of Santa Catarina(UFSC), Florianópolis/SC, 88040-900, Brazil.
authors.forename: R S
authors.initials: RS
authors.lastname: Magini
authors.affiliation: Department of Dentistry (ODT), Center for Education and Research on Dental Implants (CEPID), Post-Graduate Program in Dentistry (PPGO), Federal University of Santa Catarina(UFSC), Florianópolis/SC, 88040-900, Brazil.|Department of Mechanical Engineering (EMC), Ceramic and Composite Materials Research Group (CERMAT), Federal University of Santa Catarina, Florianópolis, 88040-900, Brazil.
authors.forename: J C M
authors.initials: JC
authors.lastname: Souza
authors.affiliation: Department of Mechanical Engineering (EMC), Ceramic and Composite Materials Research Group (CERMAT), Federal University of Santa Catarina, Florianópolis, 88040-900, Brazil.
authors.forename: M C
authors.initials: MC
authors.lastname: Fredel
authors.affiliation: Department of Materials Science and Engineering, Institute of Biomaterials, University of Erlangen-Nuremberg, 91058 Erlangen, Germany.
authors.forename: A R
authors.initials: AR
authors.lastname: Boccaccini
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000627:therapeutic use; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000737:chemistry / Q000627:therapeutic use; D002516:Ceramics / Q000737:chemistry / Q000627:therapeutic use; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans
chemical_list: D000890:Anti-Infective Agents; C022107:Bioglass; D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible
keywords: anti-biofilm activity; antibacterial compounds; bioactive glass; drug delivery system; mesoporous materials