title: Paraneoplastic Optic Neuropathy Associated With Purkinje Cell Antibody-2 in a Patient With Small Cell Lung Cancer.
abstract: Paraneoplastic optic neuropathy (PON) is a rare cause of vision loss usually associated with small cell lung cancer. Patients with this condition usually test positive for anti-collapsin response mediating protein-5 (CRMP-5). We describe a case of a 57-year-old woman with bilateral vision loss with the characteristic features of CRMP-5 PON including bilateral optic disc edema and vitreous cells. However, she was negative for anti-CRMP-5 including a negative Western blot on two occasions, but positive for Purkinje Cell Antibody (PCA)-2. Although paraneoplastic antibodies are more predictive of an underlying cancer than a specific syndrome, previously PON has not been associated with PCA-2. Based on this observation, we recommend that the workup should include PCA-2 antibodies in patients who present with bilateral optic neuropathy and vitreous cells.
authors.affiliation: Department of Ophthalmology and Vision Science, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Micieli
authors.forename: Edward A
authors.initials: EA
authors.lastname: Margolin
mesh_terms: D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000175:diagnosis; D008875:Middle Aged; D009887:Ophthalmoscopy; D009901:Optic Nerve Diseases / Q000175:diagnosis / Q000209:etiology*; D059545:Paraneoplastic Syndromes, Ocular; D055752:Small Cell Lung Carcinoma / Q000150:complications* / Q000175:diagnosis