title: A countermeasure development pipeline.
abstract: We have developed an integrated pipeline for countermeasure discovery that, under the auspices of the National Institutes of Health Countermeasures Against Chemical Threats network, is one of the few efforts within academia that by design spans the spectrum from discovery to phase I. The successful implementation of this approach for cyanide would enable efficient proof-of-concept studies that would lay the foundation for a generalizable strategy for parallel mechanistic studies and accelerated countermeasure development in the face of new and emerging chemical threats.
authors.affiliation: Brigham and Women's Hospital, Boston, Massachusetts. camacrae@bics.bwh.harvard.edu.|Harvard Medical School, Boston, Massachusetts. camacrae@bics.bwh.harvard.edu.
authors.forename: Calum A
authors.initials: CA
authors.lastname: MacRae
authors.affiliation: Department of Medicine, University of California, San Diego, San Diego, California.
authors.forename: Gerry
authors.initials: G
authors.lastname: Boss
authors.affiliation: University of California, Irvine, Irvine, California.
authors.forename: Matthew
authors.initials: M
authors.lastname: Brenner
authors.affiliation: Harvard Medical School, Boston, Massachusetts.|Massachusetts General Hospital, Charlestown, Massachusetts.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Gerszten
authors.affiliation: Department of Medicine, University of California, San Diego, San Diego, California.
authors.forename: Sari
authors.initials: S
authors.lastname: Mahon
authors.affiliation: Harvard Medical School, Boston, Massachusetts.|Massachusetts General Hospital, Charlestown, Massachusetts.
authors.forename: Randall T
authors.initials: RT
authors.lastname: Peterson
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000379:methods / Q000639:trends; D003486:Cyanides / Q000378:metabolism / Q000506:poisoning*; D055808:Drug Discovery / Q000379:methods / Q000639:trends*; D006801:Humans; D055432:Metabolomics / Q000379:methods / Q000639:trends; D009316:National Institutes of Health (U.S.) / Q000639:trends*; D016730:Program Development / Q000379:methods; D014481:United States
chemical_list: D003486:Cyanides
keywords: animal models; countermeasure; cyanide; drug discovery; metabolomics