title: Buffered Solutions Versus Isotonic Saline for Resuscitation in Nonsurgical Critically Ill: Protocol for Cochrane Review.
abstract: Fluid resuscitation is one of the most prevalent treatment in critical care. There is not definitive evidence about the best fluid for resuscitation. The aim of this review will be to asses the efficacy and safety of buffered solution versus saline. We will perform an electronic search in Medline, Embase, and Central. Studies will be eligible if they are clinical trials who including critical ill patients. Primary outcomes are mortality and renal failure. All findings will be tabulated and synthesized. We will perform a meta-analysis according to Cochrane Review standards. We will design a summary of findings table.
authors.affiliation: From the *Intensive Care Department, 12 de Octubre Hospital, Madrid, Spain; †Internal Medicine Department, La Princesa Hospital, Madrid, Spain; ‡Clinical Biostatistics Unit, Ramón y Cajal Hospital (IRYCIS), CIBER Epidemiology and Public Health (CIBERESP), Madrid, Spain; and §Medical Library, 12 de Octubre Hospital, Madrid, Spain.
authors.forename: Jesus A
authors.initials: JA
authors.lastname: Barea-Mendoza
authors.forename: Alba M
authors.initials: AM
authors.lastname: Antequera
authors.forename: Maria N
authors.initials: MN
authors.lastname: Plana
authors.forename: Mario
authors.initials: M
authors.lastname: Chico-Fernández
authors.forename: Alfonso
authors.initials: A
authors.lastname: Muriel
authors.forename: Ignacio
authors.initials: I
authors.lastname: Sáez
authors.forename: José M
authors.initials: JM
authors.lastname: Estrada-Lorenzo
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Montejo-González
mesh_terms: D006801:Humans; D002021:Buffers; D003422:Critical Care / Q000379:methods; D016638:Critical Illness / Q000628:therapy; D005440:Fluid Therapy / Q000009:adverse effects / Q000379:methods; D007262:Infusions, Intravenous; D007552:Isotonic Solutions; D015201:Meta-Analysis as Topic; D012107:Research Design; D012151:Resuscitation / Q000009:adverse effects / Q000379:methods; D012965:Sodium Chloride / Q000008:administration & dosage / Q000009:adverse effects; D016896:Treatment Outcome; D012196:Review Literature as Topic
chemical_list: D002021:Buffers; D007552:Isotonic Solutions; D012965:Sodium Chloride