title: Strategies for managing transient tachypnoea of the newborn - a systematic review.
abstract: OBJECTIVE
  To conduct a systematic review of strategies for the management of transient tachypnoea of the newborn (TTN).
  
  
  METHODS
  The Cochrane Collaboration and PRISMA guidelines were used for conducting and reporting this systematic review, respectively. The Cochrane Central Register of Controlled Trials, PubMed, CINAHL and EMBASE databases were searched in February 2016. Only randomised and quasi-randomised controlled trials (RCTs) assessing any intervention for the management of TTN in infants <7 days of age, born at 35 or more weeks with a clinical diagnosis of TTN were eligible for inclusion. Primary outcomes included the duration of respiratory support, oxygen support, tachypnoea and hospitalisation.
  
  
  RESULTS
  Nine RCTs with moderate risk of bias were included. The interventions assessed included furosemide (2 trials, n = 100), inhaled salbutamol (2 trials, n = 94), inhaled epinephrine (1 trial, n = 20), restrictive fluids (2 trials, n = 146) and non-invasive ventilation (2 trials, n = 80). Amongst all interventions, inhaled salbutamol significantly reduced the duration of hospitalisation (2 trials, n = 94) [mean difference (MD) - 1.63 days (95% CI -2.71 to -0.55); p = 0.003] and duration of oxygen requirement (1 trial, n = 37) [MD - 43.10 h (95% CI -81.82 to -4.38; p = 0.03] without adverse effects.
  
  
  CONCLUSIONS
  Limited low-quality evidence exists on the effects of different management strategies for TTN. The safety and efficacy of inhaled salbutamol in the treatment of TTN can be assessed in a large RCT.
authors.affiliation: a Department of Neonatal Paediatrics , King Edward Memorial Hospital , Perth , Western Australia.
authors.forename: Ashok
authors.initials: A
authors.lastname: Buchiboyina
authors.affiliation: a Department of Neonatal Paediatrics , King Edward Memorial Hospital , Perth , Western Australia.
authors.forename: Bonny
authors.initials: B
authors.lastname: Jasani
authors.affiliation: b Department of Neonatal Paediatrics , Fiona Stanley Hospital , Perth , Western Australia , and.
authors.forename: Mangesh
authors.initials: M
authors.lastname: Deshmukh
authors.affiliation: a Department of Neonatal Paediatrics , King Edward Memorial Hospital , Perth , Western Australia.|c Centre for Neonatal Research and Education, University of Western Australia , Perth , Western Australia.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Patole
mesh_terms: D000280:Administration, Inhalation; D000420:Albuterol / Q000008:administration & dosage*; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D004232:Diuretics; D004837:Epinephrine / Q000008:administration & dosage*; D005260:Female; D005665:Furosemide / Q000008:administration & dosage*; D006801:Humans; D007231:Infant, Newborn; D007902:Length of Stay; D008297:Male; D063087:Noninvasive Ventilation; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D059245:Transient Tachypnea of the Newborn / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D001993:Bronchodilator Agents; D004232:Diuretics; D005665:Furosemide; D000420:Albuterol; D004837:Epinephrine
keywords: Management; newborn; review; transient tachypnoea