title: Medicine in spine exercise (MiSpEx) for nonspecific low back pain patients: study protocol for a multicentre, single-blind randomized controlled trial.
abstract: Arising from the relevance of sensorimotor training in the therapy of nonspecific low back pain patients and from the value of individualized therapy, the present trial aims to test the feasibility and efficacy of individualized sensorimotor training interventions in patients suffering from nonspecific low back pain.
  
  
  
  A multicentre, single-blind two-armed randomized controlled trial to evaluate the effects of a 12-week (3 weeks supervised centre-based and 9 weeks home-based) individualized sensorimotor exercise program is performed. The control group stays inactive during this period. Outcomes are pain, and pain-associated function as well as motor function in adults with nonspecific low back pain. Each participant is scheduled to five measurement dates: baseline (M1), following centre-based training (M2), following home-based training (M3) and at two follow-up time points 6 months (M4) and 12 months (M5) after M1. All investigations and the assessment of the primary and secondary outcomes are performed in a standardized order: questionnaires - clinical examination - biomechanics (motor function). Subsequent statistical procedures are executed after the examination of underlying assumptions for parametric or rather non-parametric testing.
  
  
  
  The results and practical relevance of the study will be of clinical and practical relevance not only for researchers and policy makers but also for the general population suffering from nonspecific low back pain.
  
  
  
  Identification number DRKS00010129. German Clinical Trial registered on 3 March 2016.
authors.affiliation: Department of Sports Medicine, Goethe University Frankfurt, Ginnheimer Landstraße 39, 40487, Frankfurt am Main, Germany. niederer@sport.uni-frankfurt.de.
authors.forename: Daniel
authors.identifier: 0000-0002-7690-5418
authors.initials: D
authors.lastname: Niederer
authors.affiliation: Department of Sports Medicine, Goethe University Frankfurt, Ginnheimer Landstraße 39, 40487, Frankfurt am Main, Germany.
authors.forename: Lutz
authors.initials: L
authors.lastname: Vogt
authors.affiliation: Department of Sociology of Physical Activity and Health, Cluster of Excellence in Cognitive Sciences, University of Potsdam, Potsdam, Germany.
authors.forename: Pia-Maria
authors.initials: PM
authors.lastname: Wippert
authors.affiliation: Department of Sociology of Physical Activity and Health, Cluster of Excellence in Cognitive Sciences, University of Potsdam, Potsdam, Germany.
authors.forename: Anne-Katrin
authors.initials: AK
authors.lastname: Puschmann
authors.affiliation: Department of Orthopaedics and Trauma Surgery, Heidelberg University Hospital, Heidelberg, Germany.
authors.forename: Ann-Christin
authors.initials: AC
authors.lastname: Pfeifer
authors.affiliation: Department of Orthopaedics and Trauma Surgery, Heidelberg University Hospital, Heidelberg, Germany.
authors.forename: Marcus
authors.initials: M
authors.lastname: Schiltenwolf
authors.affiliation: Department of Sports Medicine, Goethe University Frankfurt, Ginnheimer Landstraße 39, 40487, Frankfurt am Main, Germany.
authors.forename: Winfried
authors.initials: W
authors.lastname: Banzer
authors.affiliation: University Outpatient Clinic, Centre of Sports Medicine, University of Potsdam, Potsdam, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Mayer
mesh_terms: D001696:Biomechanical Phenomena; D002985:Clinical Protocols; D005081:Exercise Therapy / Q000379:methods*; D006801:Humans; D017116:Low Back Pain / Q000503:physiopathology / Q000628:therapy*; D016037:Single-Blind Method
keywords: Exercise; Functional capacity; Individualized intervention; Low back pain; Motor control; Sensorimotor training