title: Peptide-targeted polymer cancerostatics.
abstract: A tumor-targeting drug delivery system consists of a tumor recognition moiety and a directly linked cytotoxic agent or an agent attached to a water-soluble synthetic polymer carrier through a suitable linker. Conjugation of a drug with a polymer carrier can change its solubility, toxicity, biodistribution, blood clearance and therapeutic specificity. Increased therapeutic specificity of a polymer drug can be achieved by the attachment of a targeting moiety (e.g. a lectin, protein, antibody, or peptide) that specifically interacts with receptors on the target cells. A large number of tumor-specific peptides were described in recent years. After a short introduction, some important examples of peptide-targeted conjugates will be described and discussed.
authors.affiliation: Department of Biomedicinal Polymers, Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Prague, Czech Republic. pola@imc.cas.cz.
authors.forename: E
authors.initials: E
authors.lastname: Böhmová
authors.forename: R
authors.initials: R
authors.lastname: Pola
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents; D004337:Drug Carriers; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy*; D010455:Peptides; D011108:Polymers
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D010455:Peptides; D011108:Polymers