title: Cardiovascular KATPchannels and advanced aging.
abstract: With advanced aging, there is a decline in innate cardiovascular function. This decline is not general in nature. Instead, specific changes occur that impact the basic cardiovascular function, which include alterations in biochemical pathways and ion channel function. This review focuses on a particular ion channel that couple the latter two processes, namely the KATPchannel, which opening is promoted by alterations in intracellular energy metabolism. We show that the intrinsic properties of the KATPchannel changes with advanced aging and argue that the channel can be further modulated by biochemical changes. The importance is widespread, given the ubiquitous nature of the KATPchannel in the cardiovascular system where it can regulate processes as diverse as cardiac function, blood flow and protection mechanisms against superimposed stress, such as cardiac ischemia. We highlight questions that remain to be answered before the KATPchannel can be considered as a viable target for therapeutic intervention.
authors.affiliation: Department of Pediatrics, NYU School of Medicine, New York, NY, USA.
authors.forename: Hua-Qian
authors.initials: HQ
authors.lastname: Yang
authors.affiliation: Department of Pediatrics, NYU School of Medicine, New York, NY, USA.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Subbotina
authors.affiliation: Department of Medicine, NYU School of Medicine, New York, NY, USA.|Department of Biochemistry and Molecular Pharmacology, NYU School of Medicine, New York, NY, USA.
authors.forename: Ravichandran
authors.initials: R
authors.lastname: Ramasamy
authors.affiliation: Department of Pediatrics, NYU School of Medicine, New York, NY, USA.|Department of Biochemistry and Molecular Pharmacology, NYU School of Medicine, New York, NY, USA.|Department of Physiology & Neuroscience, NYU School of Medicine, New York, NY, USA; william.coetzee@med.nyu.edu.
authors.forename: William A
authors.initials: WA
authors.lastname: Coetzee
keywords: ATP-sensitive K+ channel; aging; cardiovascular; ion channels; smooth muscle