title: TOMOGRAPHIC RELATIONSHIPS BETWEEN RETINAL NEOVASCULARIZATION AND THE POSTERIOR VITREOUS IN PROLIFERATIVE DIABETIC RETINOPATHY.
abstract: OBJECTIVE
  To describe anatomical relationships of retinal neovascular complexes (NVCs) and the posterior vitreous in proliferative diabetic retinopathy using spectral domain optical coherence tomography.
  
  
  METHODS
  Cross-sectional study. Neovascular complexes were imaged using spectral domain optical coherence tomography in 51 eyes of 37 patients. The relationship of NVCs to the posterior vitreous cortex and posterior vitreous spaces, such as the premacular bursa, prevascular vitreous fissures, and perimacular cisterns, was analyzed.
  
  
  RESULTS
  In the 77 NVCs evaluated, 61 (79%) had grown along the outer surface of the posterior hyaloid face, and vitreoschisis was present in 37 (48%). The "wolf's jaw" configuration was present in 9% and resulted from NVC arising from the arcades and proliferating along the posterior hyaloid face. By contrast, NVCs that invaded the bursa originated from smaller venous tributaries more distant from the arcades. The premacular bursa and prevascular vitreous fissure/perimacular cistern were invaded infrequently, respectively, in 15% and 38% (P = 0.137).
  
  
  CONCLUSIONS
  Tomographic analysis of diabetic NVCs showed that most NVCs arise and grow along the posterior hyaloid face and that vitreoschisis is more prevalent than what has been found in ultrasound studies. The wolf's jaw configuration does not seem to result from the invasion of the bursa, as previously suggested.
authors.affiliation: *Department of Ophthalmology, Hospital de Santa Maria, Lisbon, Portugal; †Department of Ophthalmology, Faculty of Medicine, Universidade de Lisboa, Lisbon, Portugal; ‡Vitreous Retina Macula Consultants of New York, New York, New York; §LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York; ¶Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom; and **Department of Ophthalmology, New York University School of Medicine, New York, New York.
authors.forename: Sara
authors.initials: S
authors.lastname: Vaz-Pereira
authors.forename: Kunal K
authors.initials: KK
authors.lastname: Dansingani
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Chen
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Cooney
authors.forename: James M
authors.initials: JM
authors.lastname: Klancnik
authors.forename: Michael
authors.initials: M
authors.lastname: Engelbert
mesh_terms: D003430:Cross-Sectional Studies; D003930:Diabetic Retinopathy / Q000150:complications / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000473:pathology*; D015861:Retinal Neovascularization / Q000175:diagnosis* / Q000209:etiology; D041623:Tomography, Optical Coherence / Q000379:methods*; D014822:Vitreous Body / Q000473:pathology*