title: [Genomic diversity and population structure ofHelicobacter pyloriisolates in China].
abstract: Objective:To learn about the overall genomic characteristics and population structure ofHelicobacter pyloriisolated in China.Methods:In this study, we used 10 public available genome sequences ofH. pyloristrains isolated in China, combined with otherH. pylorisequences from GenBank, to analyzed the overall genomic characteristics ofH. pyloriisolated in China. Core genes and strain specific genes were determined for a further function definition.Results:A total of 1 203 core genes were found among all sequenced ChinaH. pyloriisolates. The number of strain specific genes ranged from 19 to 32. These genes mainly encodes hypothetical proteins which might play an important role in adaption to different hosts. Genomic variation regions were mainly in genes encoding type four secretion systems and restriction modification systems. All the China isolates belong to hpEastAsia group, hspEAsia subgroup. Prophages sequences were found in three ChinaH. pyloristrains, carrying key elements required for phage assembly.Conclusion:ChinaH. pyloriisolates belong to hpEastAsia group, hspEAsia subgroup, and some isolates contain prophages.
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
authors.forename: Y H
authors.initials: YH
authors.lastname: You
authors.forename: L H
authors.initials: LH
authors.lastname: He
authors.forename: X H
authors.initials: XH
authors.lastname: Peng
authors.forename: L
authors.initials: L
authors.lastname: Sun
authors.forename: J Z
authors.initials: JZ
authors.lastname: Zhang
mesh_terms: D002681:China; D005798:Genes, Bacterial; D014644:Genetic Variation; D016680:Genome, Bacterial; D023281:Genomics; D016481:Helicobacter Infections; D016480:Helicobacter pylori / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D039002:Prophages