title: Magnetic resonance imaging of experimental autoimmune encephalomyelitis in the common marmoset.
abstract: Magnetic resonance imaging (MRI) is an invaluable tool for the diagnosis and monitoring of patients with multiple sclerosis (MS) as well as for the study of the disease pathophysiology. Because of its strong clinical, radiological and histopathological similarities with the human disease, experimental autoimmune encephalomyelitis (EAE) in the common marmoset has been studied more intensively over the past several years. Here, we review the current knowledge on MRI in the marmoset EAE, and we outline the physiopathological significance and translational values of these studies with respect to MS. Accumulating evidences suggest that the application of conventional, as well as non-conventional, MRI techniques in the marmoset EAE is a promising approach to elucidate the pathological processes underlying the development of inflammatory demyelinated lesions in the central nervous system, potentially improving the identification and development of new therapeutics.
authors.affiliation: Department of Neurology, Hôpital Erasme-Université libre de Bruxelles, Belgium.
authors.forename: Pietro
authors.initials: P
authors.lastname: Maggi
authors.affiliation: Translational Neuroradiology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Pascal
authors.initials: P
authors.lastname: Sati
authors.affiliation: Department of Neurosciences, Drug Research, and Child Health, University of Florence, Florence, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Massacesi
mesh_terms: D000818:Animals; D002144:Callithrix; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000000981:diagnostic imaging* / Q000276:immunology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000592:standards; D013045:Species Specificity
keywords: Brain; Demyelination; Experimental autoimmune encephalomyelitis; Inflammation; Magnetic resonance imaging; Marmoset; Multiple sclerosis