title: Spitting out the demons: Extracellular vesicles in glioblastoma.
abstract: Discovered decades ago, extracellular vesicles (EVs) emerge as dedicated organelles, able to deliver protected, specific cellular cues throughout the organism. While virtually every cell can release EVs, cancer cells co-opted this feature and efficiently unleashed them both in the tumor microenvironment and toward healthy tissues. This might contribute to tumor aggressiveness and spreading. Cancer-derived EVs that contain DNA, mRNA, miRNA, and packed and transmembrane proteins can operate locally or at distance. This review will focus on the high-grade brain tumor (i.e. glioblastoma)-derived EVs, discussing recent reports on i) their phenotype and content, ii) their putative functions, and iii) their clinical potential for improving diagnosis and therapeutics.
authors.affiliation: a CRCNA, CNRS, INSERM, Université de Nantes , Nantes , France.|b Team SOAP, CNRS , Nantes , France.
authors.forename: Gwennan
authors.initials: G
authors.lastname: André-Grégoire
authors.affiliation: a CRCNA, CNRS, INSERM, Université de Nantes , Nantes , France.|b Team SOAP, CNRS , Nantes , France.
authors.forename: Julie
authors.initials: J
authors.lastname: Gavard
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D004058:Diffusion; D000067128:Extracellular Vesicles / Q000378:metabolism*; D005909:Glioblastoma / Q000378:metabolism*; D006801:Humans; D057170:Translational Research, Biomedical; D059016:Tumor Microenvironment
keywords: angiogenesis; brain tumors; exosomes; glioma; permeability; signaling; tumor microenvironment