title: A Different Approach for Usage of the Implant Materials: The Composite Graft Prefabrication.
abstract: With all implanted materials, a certain sequence of biological events occurs following the implantation. This process is destructive to the implant and peri-implant tissues. The aforementioned sequence of biological events may be responsible for the complications. In this study, the natural biologic process following implantation was completed in an area other than the final implantation area. The aim was to keep the peri-implant tissues in the final implantation area away from the process. In the control group, the porous polyethylene discs were implanted to subcutaneous area on the frontal bone of the rats. A month after the implantation, macroscopic and microscopic examinations were performed. In the study group, the discs were implanted primarily above the rectus abdominis muscle of the rats. It was named as "the composite graft prefabrication." Twenty-one days after the first implantation, the discs were removed from the rectus muscle and implanted to subcutaneous area on the frontal bone of the rats. A month after the final implantation, macroscopic and microscopic examinations were performed. In macroscopic examination, all possible complications were evaluated. In microscopic examination, apoptosis, fibrosis, inflammation, and fibrovascular in-growing were evaluated. In the control group, implant exposure was observed in 3 of the rats. In the study group, no complications were observed. Although there was no statistical difference between 2 groups in the microscopic findings, at first glance, the inflammation seemed to be the factor responsible for the complication in the control group. According to the macroscopic results, the composite graft prefabrication seemed to be effective in preventing complications.
authors.affiliation: *Department of Plastic and Reconstructive Surgery, Genesis Health Center, Tekirdağ†Department of Plastic and Reconstructive Surgery, Cankiri Government Hospital, Cankiri‡Faculty of Medicine, Department of Plastic and Reconstructive Surgery, Baskent University, Ankara§Faculty of Medicine, Department of Pathology, Baskent University, Konya, Turkey.
authors.forename: Lutfi Murat
authors.initials: LM
authors.lastname: Deniz
authors.forename: Murat Görkem
authors.initials: MG
authors.lastname: Ataman
authors.forename: Huseyin
authors.initials: H
authors.lastname: Borman
authors.forename: Hilal
authors.initials: H
authors.lastname: Erinanç
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005624:Frontal Bone / Q000601:surgery*; D008297:Male; D020959:Polyethylene; D016062:Porosity; D019736:Prostheses and Implants; D011474:Prosthesis Design; D051381:Rats; D017207:Rats, Sprague-Dawley; D019651:Plastic Surgery Procedures / Q000379:methods*
chemical_list: D020959:Polyethylene