title: Positive Feedback Loops Between Inflammatory, Bone and Cancer Cells During Metastatic Niche Construction.
abstract: Bone, which includes several cell populations and numerous cytokines and chemokines that provide cell-cell signaling, is a common destination for many cancer metastases. Bone metastasis skews this signaling to develop vicious cycles between immune, bone and cancer populations that lead to abnormal bone remodeling during cancer niche construction. Temporal models utilize positive feedback systems as an integrative tool providing insights into the rate-limiting processes that determine multiple stages of the bone metastasis. We develop a logical-transient-threshold framework by linking temporal responses of the cancer, bone and immune systems through macrophages during ecological niche construction of cancer in host bone.
authors.affiliation: Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD, USA.|Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.
authors.forename: Ardeshir
authors.initials: A
authors.lastname: Kianercy
authors.affiliation: Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD, USA. kpienta1@jhmi.edu.
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Pienta
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000276:immunology / Q000378:metabolism* / Q000556:secondary; D016723:Bone Remodeling; D002450:Cell Communication; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D025461:Feedback, Physiological; D006801:Humans; D008264:Macrophages / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D008297:Male; D015233:Models, Statistical; D009360:Neoplastic Cells, Circulating / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D010006:Osteoblasts / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction; D059016:Tumor Microenvironment
chemical_list: D016207:Cytokines
keywords: Bone metastasis; Cancer ecology; Feedback systems; Tumor vicious cycle