title: Precise Inference and Characterization of Structural Organization (PICASO) of tissue from molecular diffusion.
abstract: Inferring the microstructure of complex media from the diffusive motion of molecules is a challenging problem in diffusion physics. In this paper, we introduce a novel representation of diffusion MRI (dMRI) signal from tissue with spatially-varying diffusivity using a diffusion disturbance function. This disturbance function contains information about the (intra-voxel) spatial fluctuations in diffusivity due to restrictions, hindrances and tissue heterogeneity of the underlying tissue substrate. We derive the short- and long-range disturbance coefficients from this disturbance function to characterize the tissue structure and organization. Moreover, we provide an exact relation between the disturbance coefficients and the time-varying moments of the diffusion propagator, as well as their relation to specific tissue microstructural information such as the intra-axonal volume fraction and the apparent axon radius. The proposed approach is quite general and can model dMRI signal for any type of gradient sequence (rectangular, oscillating, etc.) without using the Gaussian phase approximation. The relevance of the proposed PICASO model is explored using Monte-Carlo simulations and in-vivo dMRI data. The results show that the estimated disturbance coefficients can distinguish different types of microstructural organization of axons.
authors.affiliation: Brigham and Women's Hospital, Harvard Medical School, USA. Electronic address: lning@bwh.harvard.edu.
authors.forename: Lipeng
authors.initials: L
authors.lastname: Ning
authors.affiliation: Department of Biomedical Engineering, Linköping University, Sweeden.
authors.forename: Evren
authors.initials: E
authors.lastname: Özarslan
authors.affiliation: Brigham and Women's Hospital, Harvard Medical School, USA.
authors.forename: Carl-Fredrik
authors.initials: CF
authors.lastname: Westin
authors.affiliation: Brigham and Women's Hospital, Harvard Medical School, USA.
authors.forename: Yogesh
authors.initials: Y
authors.lastname: Rathi
mesh_terms: D001369:Axons; D001921:Brain / Q000033:anatomy & histology*; D001931:Brain Mapping / Q000379:methods*; D004058:Diffusion; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted
keywords: Bloch-Torrey equation; Diffusion MRI; Diffusion equation; Kurtosis; Structural disorder; Time-dependent diffusion; Tissue microstructure