title: BDNF mRNA abundance regulated by antidromic action potentials and AP-LTD in hippocampus.
abstract: Action-potential-induced LTD (AP-LTD) is a form of synaptic plasticity that reduces synaptic strength in CA1 hippocampal neurons firing antidromically during sharp-wave ripples. This firing occurs during slow-wave sleep and quiet moments of wakefulness, which are periods of offline replay of neural sequences learned during encoding sensory information. Here we report that rapid and persistent down-regulation of different mRNA transcripts of the BDNF gene accompanies AP-LTD, and that AP-LTD is abolished in mice with the BDNF gene knocked out in CA1 hippocampal neurons. These findings increase understanding of the mechanism of AP-LTD and the cellular mechanisms of memory consolidation.
authors.affiliation: Nervous System Development and Plasticity Section, The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), United States.
authors.forename: Olena
authors.initials: O
authors.lastname: Bukalo
authors.affiliation: Nervous System Development and Plasticity Section, The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), United States.
authors.forename: Philip R
authors.initials: PR
authors.lastname: Lee
authors.affiliation: Nervous System Development and Plasticity Section, The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), United States. Electronic address: fieldsd@mail.nih.gov.
authors.forename: R Douglas
authors.initials: RD
authors.lastname: Fields
mesh_terms: D000200:Action Potentials; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics / Q000378:metabolism*; D020746:Calcium Channels, L-Type / Q000378:metabolism; D006624:Hippocampus / Q000502:physiology*; D036881:Long-Term Synaptic Depression; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism*; D017207:Rats, Sprague-Dawley
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D020746:Calcium Channels, L-Type; D012333:RNA, Messenger
keywords: Antidromic action potentials; BDNF; LTD; Sharp wave ripple complexes; Slow wave sleep