title: Incidentally Detected Kaposi Sarcoma of Adrenal Gland with Anaplastic Features in an HIV Negative Patient.
abstract: Kaposi sarcoma (KS), a vascular tumor caused by infection with human herpesvirus 8 (HHV8), is a systemic disease that can present with cutaneous lesions with or without visceral involvement. Very few cases of KS, most of which were associated with AIDS, have been reported in the adrenal gland. Anaplastic transformation of KS is a rare clinical presentation known as an aggressive disease with local recurrence and metastatic potential. We report here a 47-year-old HIV negative male presented with extra-adrenal symptoms and had an incidentally detected anaplastic adrenal KS exhibited aggressive clinical course. To the best of our knowledge, this is the first case of anaplastic primary adrenal KS without mucocutaneous involvement but subsequently developed other side adrenal metastases in an HIV negative patient.
authors.affiliation: Pathology Department, Faculty of Medicine, Selçuk University, Alaaddin Keykubat Campus, Selçuklu, 42000 Konya, Turkey.
authors.forename: Zeliha Esin
authors.identifier: 0000-0002-3220-7845
authors.initials: ZE
authors.lastname: Celik
authors.affiliation: Pathology Department, Faculty of Medicine, Selçuk University, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Celik
authors.affiliation: Clinical Oncology Department, Faculty of Medicine, Selçuk University, Turkey.
authors.forename: Erdem
authors.initials: E
authors.lastname: Sen
authors.affiliation: Radiology Department, Faculty of Medicine, Selçuk University, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Cebeci
authors.affiliation: Clinical Oncology Department, Faculty of Medicine, Selçuk University, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Ata
authors.affiliation: Radiation Oncology Department, Faculty of Medicine, Selçuk University, Turkey.
authors.forename: Cagdas
authors.initials: C
authors.lastname: Yavas