title: Computational Modelling of Magnetic Nanoparticle Properties and In Vivo Responses.
abstract: Nanoparticles are finding many applications in medicine and other fields like photonics. Magnetic nanoparticles have additional advantages in medicine over non-magnetic hard nanoparticles, as their magnetic properties make them ideal for hyperthermic applications in therapy and for sensitive diagnostic imaging applications. I review the literature on computational models of the magnetic properties of nanoparticles specifically. Such models have the potential to accelerate the design of magnetic nanoparticles for medical applications. Much of the current literature relates to the modelling of magnetic nanoparticles for inducing hyperthermia in aberrant cells, with significant bodies of work aimed at simulating and predicting properties for medical imaging and targeted delivery of drugs and gene therapies.
authors.affiliation: CSIRO Manufacturing, Bag 10, Clayton South MDC 3169. Australia.
authors.forename: David A
authors.initials: DA
authors.lastname: Winkler
mesh_terms: D000818:Animals; D003198:Computer Simulation; D016503:Drug Delivery Systems / Q000379:methods*; D020342:Finite Element Analysis; D018014:Gene Transfer Techniques; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use*; D008954:Models, Biological; D008956:Models, Chemical
chemical_list: D058185:Magnetite Nanoparticles
keywords: Magnetic nanoparticles; cancer; cellular uptake; computational modelling; delivery.; finite element analysis; hyperthermia