title: Orthogonal Synthesis of Xeno Nucleic Acids.
abstract: Sequence-defined peptide triazole nucleic acids (PTzNA) were synthesized by means of a solid-phase orthogonal "AB+CD" iterative strategy. In this approach, AB and CD building blocks containing carboxylic acid (A), azide (B), alkyne (C), and primary amine (D) functions are assembled together by successive copper-catalyzed azide-alkyne cycloaddition (CuAAC) and acid-amine coupling steps. Different PTzNA genetic sequences were prepared using a library of eight building blocks (i.e., four AB and four CD building blocks).
authors.affiliation: Precision Macromolecular Chemistry Group, Institut Charles Sadron, 23 rue du Loess, BP84047, 67034, Strasbourg Cedex 2, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Fiers
authors.affiliation: Precision Macromolecular Chemistry Group, Institut Charles Sadron, 23 rue du Loess, BP84047, 67034, Strasbourg Cedex 2, France.|Laboratoire de Catalyse et Synthèse en Chimie Organique, Université Abou Bekr Belkaid, BP 119 Pole Imama Bât. B, 13000, Tlemcen, Algeria.
authors.forename: Dalila
authors.initials: D
authors.lastname: Chouikhi
authors.affiliation: Precision Macromolecular Chemistry Group, Institut Charles Sadron, 23 rue du Loess, BP84047, 67034, Strasbourg Cedex 2, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Oswald
authors.affiliation: Precision Macromolecular Chemistry Group, Institut Charles Sadron, 23 rue du Loess, BP84047, 67034, Strasbourg Cedex 2, France.
authors.forename: Abdelaziz
authors.initials: A
authors.lastname: Al Ouahabi
authors.affiliation: Precision Macromolecular Chemistry Group, Institut Charles Sadron, 23 rue du Loess, BP84047, 67034, Strasbourg Cedex 2, France.
authors.forename: Delphine
authors.identifier: http://orcid.org/0000-0003-3508-2491
authors.initials: D
authors.lastname: Chan-Seng
authors.affiliation: Aix Marseille Univ, CNRS, Institute of Radical Chemistry, UMR 7273, Marseille, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Charles
authors.affiliation: Precision Macromolecular Chemistry Group, Institut Charles Sadron, 23 rue du Loess, BP84047, 67034, Strasbourg Cedex 2, France.
authors.forename: Jean-François
authors.identifier: http://orcid.org/0000-0002-3893-2458
authors.initials: JF
authors.lastname: Lutz
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000595:Amino Acid Sequence; D001386:Azides / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D061565:Cycloaddition Reaction; D009696:Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D001386:Azides; D002264:Carboxylic Acids; D009696:Nucleic Acids; D003300:Copper
keywords: iterative chemistry; nucleic acids; orthogonal synthesis; sequence-controlled polymers; solid-phase synthesis