title: Early postoperative recovery after intracranial surgical procedures. Comparison of the effects of sevoflurane and desflurane.
abstract: To compared the effects of sevoflurane and desflurane on early anesthesia recovery in patients undergoing to craniotomy for intracranial lesions.
  After IRB approval, the study included 50 patients aged 18-70 years who had ASA physical statuses of I-II and were scheduled for intracranial surgery. Patients were randomly divided into two groups: sevoflurane and desflurane. Anaesthesia was routinely induced in all patients followed by desflurane 5%-6% or sevoflurane 1%-2%. Moreover remifentanil infusion (0.05-0.2 mcg/kg/min) was adjusted to maintain mean arterial pressure (MAP) within 20% baseline and heart rate <90 bpm. Postoperatively, patients were evaluated over time for responses to painful stimulus, eye opening, hand squeezing, extubation, orientation and time required to achieve a Modified Aldrete Score of 9-10. Parametric and non-parametric data were assessed using Student's t- and Mann-Whitney U tests, respectively. A p<0.05 was taken as statistically significant.
  The times to responses to painful stimuli (7.7±2.7 vs. 4.8±1.7 min.; p<0.001), emergence (9.5±2.81 vs. 6.3±2.2 min.; p<0.001), hand-squeezing (12.1±2.9 vs. 8.2±2.3 min.; p<0.001), extubation (10.1±2.87 vs. 7.1±1.6 min.; p<0.001), orientation (15.3±3.2 vs. 10.3±2.7 min.; p<0.001) and Aldrete score of 9-10 (23.3±6.1 vs. 15.8±3.8 min.; p<0.001) were significantly lower with desflurane-based anaesthesia vs. sevoflurane-based anaesthesia.
  Desflurane yields early recovery functions and facilitates early postoperative neurologic examinations of intracranial surgery patients.
authors.affiliation: MD, Department of Aneaesthesiolgy, Diyarbakır Selahaddini Eyyubi State Hospital, Turkey. Intellectual, scientific and design of the study; acquisition and interpretation of data; manuscript writing.
authors.forename: Erhan
authors.initials: E
authors.lastname: Gökçek
authors.affiliation: MD, Department of Aneaesthesiolgy, Diyarbakır Selahaddini Eyyubi State Hospital, Turkey. Acquisition and interpretation of data, manuscript writing, critical revision.
authors.forename: Ayhan
authors.initials: A
authors.lastname: Kaydu
authors.affiliation: MD, Department of Aneaesthesiolgy, İstanbul Umraniye Research and Education Hospital, Turkey. Design of the study, acquisition and interpretation of data.
authors.forename: Mehmet Salim
authors.initials: MS
authors.lastname: Akdemir
authors.affiliation: MD, Department of Otorhinolaryngology, Diyarbakır Selahaddini Eyyubi State Hospital, Turkey. Acquisition and interpretation of data, statistical analysis.
authors.forename: Ferit
authors.initials: F
authors.lastname: Akil
authors.affiliation: Head, Division of Neuroanesthesia, Department of Aneaesthesiolgy, Faculty of Medicine, İstanbul University, Turkey. Intellectual and scientific content of the study, manuscript writing, critical revision.
authors.forename: Ibrahim Ozkan
authors.initials: IO
authors.lastname: Akıncı
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000762:Anesthesia Recovery Period; D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D001930:Brain Injuries / Q000601:surgery; D003399:Craniotomy / Q000379:methods*; D000077335:Desflurane; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007530:Isoflurane / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage*; D008875:Middle Aged; D011184:Postoperative Period; D011446:Prospective Studies; D000077149:Sevoflurane; D055815:Young Adult
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D000077335:Desflurane; D007530:Isoflurane