title: CD127 Expression in Naive and Memory T Cells in HIV Patients Who Have Undergone Long-Term HAART.
abstract: OBJECTIVE
  To evaluate cluster of differentiation (CD)127 expression in T cells of patients with HIV-1 and the relationship of CD127 expression with disease progression.
  
  
  METHODS
  We divided 139 patients infected with human immunodeficiency virus type 1 (HIV-1) who had undergone highly active antiretroviral therapy (HAART) into 3 groups: patients with poor recovery (CD4+T < 350/μ;L, patients with general recovery (CD4+T =  350 - ∼600/μL) and patients with good recovery (CD4+T > 600/μL). Counts and percentages of naïve (CD45RA+) and memory (CD45RO+) T cells and CD127 expression were determined using flow cytometry.
  
  
  RESULTS
  CD4+CD45RO+, CD4+CD45RA+, CD4+CD45RO+CD127+, and CD4+CD45RA+CD127+T-cell counts in patients with good recovery were higher than in patients with poor recovery and those with general recovery patients (P <.05). Percentages of CD45RO+were increased, and percentages of CD45RA+and CD127 in T cells were decreased in patients with poor and general recovery (P <.05). CD127 values were positively correlated with CD4+T-cell counts and percentages of CD45RA+subsets (P <.05).
  
  
  CONCLUSIONS
  CD127 expression in T cells is decreased in patients with HIV-1 and is related to recovery of CD4+T-cell counts and to naïve subsets.
authors.affiliation: Clinical Laboratory, Shao Xing Municipal Hospital, Shaoxing, China.
authors.forename: Wenfang
authors.initials: W
authors.lastname: Xu
authors.affiliation: Department of Infectious Diseases, Shao Xing Municipal Hospital, Shaoxing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Infectious Diseases, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Infectious Diseases, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Jiankang
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Infectious Diseases, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Zhong
authors.affiliation: Clinical Laboratory, Shao Xing Municipal Hospital, Shaoxing, China.
authors.forename: Qiuqiong
authors.initials: Q
authors.lastname: Lv
authors.affiliation: Department of Infectious Diseases, Taizhou Hospital Affiliated with Wenzhou Medical College, Linhai, China, andrewhui@163.com rhp8015071@163.com.
authors.forename: Hui
authors.initials: H
authors.lastname: Shao
authors.affiliation: Department of Nursing, School of Medicine, Quzhou College of Technology, Quzhou, China andrewhui@163.com rhp8015071@163.com.
authors.forename: Heping
authors.initials: H
authors.lastname: Rao
mesh_terms: D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active / Q000706:statistics & numerical data*; D005260:Female; D005434:Flow Cytometry; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000378:metabolism*; D006801:Humans; D053699:Interleukin-7 Receptor alpha Subunit / Q000032:analysis* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000378:metabolism*
chemical_list: D019380:Anti-HIV Agents; D053699:Interleukin-7 Receptor alpha Subunit
keywords: AIDS; CD127; HAART; HIV-1; memory T cell; naïve T cell