title: Spatial organization based reciprocal switching of enzyme-free nucleic acid circuits.
abstract: We report a new nucleic acid sensing strategy through an intelligent design of spatial organization based reciprocal switching of catalytic hairpin assembly (CHA). The so-called SORS-CHA not only turns a well-designed CHA circuit into a relatively universal detector for any targeting sequence, but also guarantees a much enhanced signal resolution and a believability to minimize the misreading induced by unexpected signal drifts. With more trustworthy results, but a simpler sequence design, nucleic acid circuits could become competitive in real-world applications.
authors.affiliation: State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, Jilin 130022, P. R. China. Binglingli@ciac.ac.cn and University of Chinese Academy of Sciences, Beijing, 100039, China.
authors.forename: Yidan
authors.initials: Y
authors.lastname: Tang
authors.affiliation: State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, Jilin 130022, P. R. China. Binglingli@ciac.ac.cn and University of Chinese Academy of Sciences, Beijing, 100039, China.
authors.forename: Zhentong
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, Jilin 130022, P. R. China. Binglingli@ciac.ac.cn.
authors.forename: Baiyang
authors.initials: B
authors.lastname: Lu
authors.affiliation: State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, Jilin 130022, P. R. China. Binglingli@ciac.ac.cn.
authors.forename: Bingling
authors.initials: B
authors.lastname: Li
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D002384:Catalysis; D004277:DNA, Single-Stranded / Q000737:chemistry*; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D009693:Nucleic Acid Hybridization; D009696:Nucleic Acids / Q000737:chemistry*
chemical_list: D004277:DNA, Single-Stranded; D009696:Nucleic Acids