title: Theranostic Treatment of Metastatic Bone Pain With 177Lu-DOTMP.
abstract: Radiochemical studies and biological evaluation in animal models have shown superior radiochemical properties and better clearance pattern for Lu-DOTMP compared with Lu-EDTMP, an agent recently proven to be efficacious and safe for metastatic bone pain palliation. This prompted us to initiate the clinical evaluation of Lu-DOTMP. The images represent the whole-body scans of a prostate cancer patient (man, 67 years) with skeletal metastases recorded after administering 3.7 GBq (100 mCi) of Lu-DOTMP.
authors.affiliation: From the *Radiopharmaceuticals Chemistry Section, Radiochemistry and Isotope Group, Bhabha Atomic Research Centre, Mumbai; †Homi Bhabha National Institute, Mumbai; and ‡Department of Nuclear Medicine and PET, Kovai Medical Center and Hospital, Coimbatore, Tamil Nadu, India.
authors.forename: Tapas
authors.initials: T
authors.lastname: Das
authors.forename: Ajit
authors.initials: A
authors.lastname: Shinto
authors.forename: Koramadai
authors.initials: K
authors.lastname: Karuppuswamy Kamaleshwaran
authors.forename: Sharmila
authors.initials: S
authors.lastname: Banerjee
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy / Q000556:secondary; D006801:Humans; D008297:Male; D009942:Organometallic Compounds / Q000627:therapeutic use*; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy; D019275:Radiopharmaceuticals / Q000627:therapeutic use*
chemical_list: C531954:177Lu-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonic acid); D009942:Organometallic Compounds; D019275:Radiopharmaceuticals