title: Gentamicin Susceptibility among a Sample of Multidrug-Resistant Neisseria gonorrhoeae Isolates in India.
abstract: Antimicrobial susceptibility testing of 258 Neisseria gonorrhoeae isolates by Etest determined that 60.1% were multidrug resistant (MDR), while 5% of the strains had decreased susceptibility to currently recommended extended-spectrum cephalosporins (ESCs). Among these, 84.5% of MDR strains and 76.9% of strains that had decreased susceptibility to ESCs were susceptible to gentamicin. No MDR isolate was resistant to gentamicin. These in vitro results suggest that gentamicin might be an effective treatment option for the MDR strains and in dual therapy for gonorrhea. However, further research regarding the clinical treatment outcomes is essential.
authors.affiliation: Apex Regional STD Teaching, Training & Research Centre, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India manjubala_2@hotmail.com.
authors.forename: Manju
authors.initials: M
authors.lastname: Bala
authors.affiliation: Apex Regional STD Teaching, Training & Research Centre, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.|Department of Life Sciences, SunRise University, Alwar, Rajasthan, India.
authors.forename: Vikram
authors.initials: V
authors.lastname: Singh
authors.affiliation: Apex Regional STD Teaching, Training & Research Centre, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.
authors.forename: Aradhana
authors.initials: A
authors.lastname: Bhargava
authors.affiliation: Apex Regional STD Teaching, Training & Research Centre, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.
authors.forename: Monika
authors.initials: M
authors.lastname: Kakran
authors.affiliation: Apex Regional STD Teaching, Training & Research Centre, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.
authors.forename: Naveen Chandra
authors.initials: NC
authors.lastname: Joshi
authors.affiliation: Department of Life Sciences, SunRise University, Alwar, Rajasthan, India.
authors.forename: Ravi
authors.initials: R
authors.lastname: Bhatnagar
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D005260:Female; D005839:Gentamicins / Q000494:pharmacology*; D006069:Gonorrhea / Q000178:diet therapy / Q000382:microbiology; D006801:Humans; D007194:India; D008297:Male; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D005839:Gentamicins