title: Socket Preservation with d-PTFE Membrane: Histologic Analysis of the Newly Formed Matrix at Membrane Removal.
abstract: This study aimed to evaluate the efficacy of an exposed high-density polytetrafluoroethylene (d-PTFE) membrane in preventing epithelial migration in postextraction sockets. For this purpose, a histologic description of the newly formed soft tissue underlying the membrane is presented. The periodontal status of the adjacent teeth was also evaluated to assess the gingival response. Ten premolar extraction sockets were treated. After tooth extraction, the sockets were filled with nanocrystalline hydroxyapatite and covered with d-PTFE membranes. Subperiosteal pockets were created to ensure the stability of the membranes. Membranes were left intentionally exposed and were atraumatically removed after 28 days. At that time, a bioptic specimen of the newly formed soft tissue under the membranes was taken. All the histologic samples showed a dense connective tissue without epithelial cells and no signs of foreign body reaction. No significant variation of the periodontal indices was observed on the teeth adjacent to the extraction sites. The study results indicate that exposed d-PTFE membranes can prevent epithelial migration in healing sockets without consequences on the periodontal health.
authors.forename: Domenico
authors.initials: D
authors.lastname: Laurito
authors.forename: Riccardo
authors.initials: R
authors.lastname: Cugnetto
authors.forename: Marco
authors.initials: M
authors.lastname: Lollobrigida
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Guerra
authors.forename: Annarita
authors.initials: A
authors.lastname: Vestri
authors.forename: Francesca
authors.initials: F
authors.lastname: Gianno
authors.forename: Sandro
authors.initials: S
authors.lastname: Bosco
authors.forename: Luca
authors.initials: L
authors.lastname: Lamazza
authors.forename: Alberto
authors.initials: A
authors.lastname: De Biase
mesh_terms: D000328:Adult; D001641:Bicuspid; D017886:Durapatite / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D011138:Polytetrafluoroethylene / Q000627:therapeutic use*; D020390:Tooth Socket / Q000601:surgery*; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D008567:Membranes, Artificial; D011138:Polytetrafluoroethylene; D017886:Durapatite