title: Tumor Promoting Aspects of Senescence in Cancer Progression.
abstract: Cancers induced by gene mutation, deletion, and genome instability might be related to aging. With similar pathways of aging but distinct functions, senescence at the cellular level is an irreversible arrest of cell cycle. Senescence has long been believed as a barrier to restrict tumor expansion. However, more and more evidence has been shown that senescence inducers regulate epithelial-mesenchymal transition, stem cell self-renewal, inflammatory response, crosstalk with the oncogenic bypass signaling, and conversion of oncogene to tumor suppressor. Here we will discuss the most recent findings of the oncogenic aspects of senescence which crosstalk with multiple pathways in cancer progression.
authors.affiliation: a Department of Biology , School of Science and Technology, Nazarbayev University , Astana , Kazakhstan.
authors.forename: Qing
authors.initials: Q
authors.lastname: Yang
authors.affiliation: a Department of Biology , School of Science and Technology, Nazarbayev University , Astana , Kazakhstan.
authors.forename: Yingqiu
authors.initials: Y
authors.lastname: Xie
authors.affiliation: b College of Basic Medicine, Wuhan University , Wuhan , China.
authors.forename: Lixia
authors.initials: L
authors.lastname: Miao
keywords: Senescence; cancer