title: Shedding Light on the 2016 World Health Organization Classification of Tumors of the Central Nervous System in the Era of Radiomics and Radiogenomics.
abstract: The new World Health Organization classification of brain tumors depends on combining the histologic light microscopy features of central nervous system (CNS) tumors with canonical genetic alterations. This integrated diagnosis is redrawing the pedigree chart of brain tumors with rearrangement of tumor groups on the basis of geno-phenotypical behaviors into meaningful groups. Multiple radiogenomic studies provide a bridge between imaging features and tumor microenvironment. An overlap that can be integrated within the genophenotypical classification of CNS tumors for a better understanding of different clinically relevant entities.
authors.affiliation: Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Unit 1482, Room # FCT 16.5037, Houston, TX 77030, USA. Electronic address: rcolen@mdanderson.org.
authors.forename: Rivka R
authors.initials: RR
authors.lastname: Colen
authors.affiliation: Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Unit 1482, Room # FCT 16.5037, Houston, TX 77030, USA.
authors.forename: Islam
authors.initials: I
authors.lastname: Hassan
authors.affiliation: Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Unit 1482, Room # FCT 16.5037, Houston, TX 77030, USA.
authors.forename: Nabil
authors.initials: N
authors.lastname: Elshafeey
authors.affiliation: Department of Neurosurgery, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
authors.forename: Pascal O
authors.initials: PO
authors.lastname: Zinn
mesh_terms: D016543:Central Nervous System Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000235:genetics*; D023281:Genomics; D006801:Humans; D008279:Magnetic Resonance Imaging; D008859:Microscopy, Polarization; D014944:World Health Organization
keywords: Central nervous system; Radiogenomic; Radiomics; Tumors; WHO Classification