title: Vertebral Artery Hypoplasia and Posterior Circulation Infarction in Patients with Isolated Vertigo with Stroke Risk Factors.
abstract: BACKGROUND
  We aimed in this study to investigate the prevalence of vertebral artery hypoplasia (VAH) in a population with isolated vertigo in association with stroke risk factors, to determine whether VAH is an independent risk factor for posterior circulation infarction (PCI).
  
  
  METHODS
  We sequentially enrolled 245 patients with isolated vertigo with at least 1 vascular risk factor, who were divided into PCI and non-PCI groups, according to present signs of acute infarction on diffusion-weighted magnetic resonance imaging. All patients underwent magnetic resonance angiography and cervical contrast-enhanced magnetic resonance angiography to screen for VAH. Univariate and multivariate logistic regression analyses were performed to identify the significant risk factors for PCI.
  
  
  RESULTS
  VAH was found in 64 of 245 patients (26%). VAH (odds ratio [OR] = 2.70, 95%confidence interval [CI] 1.17-6.23, P = .020), median stenosis of the posterior circulation (OR = 7.09, 95%CI = 2.54-19.79, P < .001), and diabetes mellitus (OR = 3.13, 95%CI 1.38-7.12, P = .006) were independent risk factors for PCI. The predominant Trial of Org 10172 in Acute Stroke Treatment subtype in our patients with isolated vertigo with PCI complicated by VAH was mainly small-artery occlusion.
  
  
  CONCLUSIONS
  Our findings suggest that VAH is an independent risk factor for PCI in patients with isolated vertigo with confirmed risk from stroke.
authors.affiliation: Department of Neurology, Zhengzhou People's Hospital, Zhengzhou 450003, China. Electronic address: zhangdaopei89@163.com.
authors.forename: Dao Pei
authors.initials: DP
authors.lastname: Zhang
authors.affiliation: Anyang Area Hospital of Puyang city, Anyang City 455000, China.
authors.forename: Gui Feng
authors.initials: GF
authors.lastname: Lu
authors.affiliation: Department of Neurology, People's Hospital of Henan Province, Zhengzhou 450003, China. Electronic address: zhangjiewen9900@126.com.
authors.forename: Jie Wen
authors.initials: JW
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Zhengzhou People's Hospital, Zhengzhou 450003, China.
authors.forename: Shu Ling
authors.initials: SL
authors.lastname: Zhang
authors.affiliation: Department of Neurology, People's Hospital of Henan Province, Zhengzhou 450003, China.
authors.forename: Qian Kun
authors.initials: QK
authors.lastname: Ma
authors.affiliation: Department of CT and MRI, Zhengzhou People's Hospital, Zhengzhou 450003, China.
authors.forename: Suo
authors.initials: S
authors.lastname: Yin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020520:Brain Infarction / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology*; D002533:Cerebral Angiography; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D016015:Logistic Models; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors; D020521:Stroke / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology*; D014711:Vertebral Artery / Q000002:abnormalities* / Q000000981:diagnostic imaging; D014717:Vertigo / Q000150:complications* / Q000000981:diagnostic imaging / Q000453:epidemiology
keywords: Vertigo; hypoplasia; stroke; vertebral artery; vertebrobasilar insufficiency