title: Autosomal Dominant Polycystic Disease is Associated with Depressed Levels of Soluble Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand.
abstract: BACKGROUND
  Autosomal dominant polycystic kidney disease (ADPKD) is characterized by multiple, large renal cysts and impaired kidney function. Although the reason for the development of kidney cysts is unknown, ADPKD is associated with cell cycle arrest and abundant apoptosis of renal tubular epithelial cells.
  
  
  OBJECTIVE
  We asked whether serum-soluble TNF-related apoptosis-inducing ligand (sTRAIL) might underlie ADPKD.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  Serum sTRAIL levels were measured in 44 patients with ADPKD and 18 healthy volunteers. The human soluble TRAIL/Apo2L ELISA kit was used for the in vitro quantitative determination of sTRAIL in serum samples.
  
  
  RESULTS
  Mean serum sTRAIL levels were lower in patients with ADPKD as compared to the control group (446.9±103.1 and 875.9±349.6 pg/mL, p<0.001). Serum sTRAIL levels did not differ among stages of renal failure in patients with ADPKD. There was no correlation between serum sTRAIL levels and estimated glomerular filtration rate in patients with ADPKD (p>0.05).
  
  
  CONCLUSIONS
  Our results show that ADPKD patients have depressed sTRAIL levels, indicating apoptosis unrelated to the stage of chronic renal failure.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Antalya Training and Research Hospital, Antalya, Turkey.
authors.forename: Funda
authors.initials: F
authors.lastname: Sarı
authors.affiliation: Department of Internal Medicine, Antalya Training and Research Hospital, Antalya, Turkey.
authors.forename: Arzu Didem
authors.initials: AD
authors.lastname: Yalçın
authors.affiliation: Department of Biochemistry, Akdeniz University School of Medicine, Antalya, Turkey.
authors.forename: Gizem Esra
authors.initials: GE
authors.lastname: Genç
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Antalya Training and Research Hospital, Antalya, Turkey.
authors.forename: Metin
authors.initials: M
authors.lastname: Sarıkaya
authors.affiliation: Department of Clinical and Experimental Medicine, University of Linköping School of Health Sciences, Linköping, Sweden.
authors.forename: Atıl
authors.initials: A
authors.lastname: Bisgin
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Antalya Training and Research Hospital, Antalya, Turkey.
authors.forename: Ramazan
authors.initials: R
authors.lastname: Çetinkaya
authors.affiliation: Department of Biochemistry, Akdeniz University School of Medicine, Antalya, Turkey.
authors.forename: Saadet
authors.initials: S
authors.lastname: Gümüşlü
keywords: Serum-soluble TNF-related apoptosis-inducing ligand; autosomal dominant polycystic kidney disease; chronic kidney disease