title: Polymorphism of the XRCC1 Gene Is Associated with Susceptibility and Short-Term Recovery of Ischemic Stroke.
abstract: Background:Base excision repair (BER) is the primary DNA repair system with the ability to fix base lesions caused by oxidative damage. Genetic variants influencing the BER pathway may affect the susceptibility and the outcomes of ischemic stroke. Here, we examined how single nucleotide polymorphisms (SNPs) associated with BER impact susceptibility and short-term recovery of ischemic stroke.Methods:We selected 320 ischemic stroke patients and 303 controls. Then we genotyped SNPs ofNEIL1rs4462560,NEIL3rs12645561 andXRCC1rs25487 in both groups.Results:Polymorphism inXRCC1rs25487 was significantly associated with reduced ischemic stroke (IS) risk (dominant model: OR = 0.53, 95% CI = 0.36-0.79,p= 0.002), a milder initial stroke (dominant model: OR = 0.57, 95% CI = 0.33-0.98,p= 0.043), and also a better short-term recovery (dominant model: OR = 0.57, 95% CI = 0.35-0.92,p= 0.022). No association was observed in the other two SNPs.Conclusions:Our study suggests that the genetic variant ofXRCC1rs25487 may contribute to the etiology of ischemic stroke.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China. hewei861113@126.com.|Department of Rehabilitation Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. hewei861113@126.com.
authors.forename: Wei
authors.initials: W
authors.lastname: He
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China. hp19880310@163.com.
authors.forename: Peng
authors.initials: P
authors.lastname: Huang
authors.affiliation: Department of Neurology, Medical College, The Affiliated Jiangyin People's Hospital of Southeast University, Wuxi 214400, China. liudinghuajy@126.com.
authors.forename: Dinghua
authors.initials: D
authors.lastname: Liu
authors.affiliation: Department of Neurology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an 223300, China. zll13299@163.com.
authors.forename: Lingling
authors.initials: L
authors.lastname: Zhong
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China. rongbinyu@njmu.edu.cn.
authors.forename: Rongbin
authors.initials: R
authors.lastname: Yu
authors.affiliation: Department of Rehabilitation Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. lijianan@carm.org.cn.
authors.forename: Jianan
authors.initials: J
authors.lastname: Li
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D045647:DNA Glycosylases / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D020521:Stroke / Q000473:pathology*; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human; D045647:DNA Glycosylases; C473634:NEIL1 protein, human
keywords: SNPs; XRCC1; base excision repair; ischemic stroke; prognosis