title: Complimentary Pattern of Uptake in 18F-FDG PET/CT and 68Ga-Prostate-Specific Membrane Antigen PET/CT in a Case of Metastatic Clear Cell Renal Carcinoma.
abstract: We describe a case of metastatic clear cell renal cell carcinoma with intensely tracer concentrating lesions in left suprarenal region, mediastinal lymph nodes, lytic bone lesions, thyroid nodules, and mild abnormal tracer-avid lung nodules in Ga-prostate-specific membrane antigen (PSMA) PET/CT. On the other hand F-FDG PET/CT showed mild to no significant abnormal uptake in these lesions. Complimentary uptake pattern was observed in Ga-PSMA and F-FDG PET images in thyroid lesions and D5 vertebral lesion. This case highlights the possibilities of imaging clear cell renal cell carcinoma with Ga-PSMA and opens the possibility of treatment with Lu-PSMA.
authors.affiliation: From the *Nuclear Medicine and PET/CT, KIMS-DDNMRC, Thiruvananthapuram, Kerala; and †Radiology and ‡Radiation Oncology, KIMS Hospital, Thiruvananthapuram, Kerala, India.
authors.forename: Arun
authors.initials: A
authors.lastname: Sasikumar
authors.forename: Ajith
authors.initials: A
authors.lastname: Joy
authors.forename: Raviteja
authors.initials: R
authors.lastname: Nanabala
authors.forename: Madhavan
authors.initials: M
authors.lastname: Unni
authors.forename: Padmanabhan
authors.initials: P
authors.lastname: Tk
mesh_terms: D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000000981:diagnostic imaging* / Q000473:pathology; D004492:Edetic Acid / Q000031:analogs & derivatives; D005260:Female; D019788:Fluorodeoxyglucose F18; D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D006801:Humans; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D009362:Neoplasm Metastasis; D009842:Oligopeptides; D009942:Organometallic Compounds; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D009842:Oligopeptides; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; C000718244:gallium 68 PSMA-11; D019788:Fluorodeoxyglucose F18; D004492:Edetic Acid