title: Adenosine Analog NITD008 Is a Potent Inhibitor of Zika Virus.
abstract: The ongoing Zika virus (ZIKV) outbreaks have raised global concerns due to its unexpected clinical manifestations. Antiviral development is of high priority in response to the ZIKV emergency. In this study, we report that an adenosine analog NITD008 has potent in vitro and in vivo antiviral activity against ZIKV. The compound can effectively inhibit the historical and contemporary ZIKV strains in cultures as well as significantly reduce viremia and prevent mortality in A129 mice. Our results have demonstrated that NITD008 is potent inhibitor of ZIKV and can be used as reference inhibitor for future ZIKV antiviral drug screen and discovery.
authors.affiliation: Department of Virology, Beijing Institute of Microbiology and Epidemiology; State Key Laboratory of Pathogen and Biosecurity, Beijing.
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Deng
authors.affiliation: Department of Virology, Beijing Institute of Microbiology and Epidemiology; Guangxi Medical University, Nanning.
authors.forename: Na-Na
authors.initials: NN
authors.lastname: Zhang
authors.affiliation: Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Suzhou Institute of Systems Medicine, Jiangsu.
authors.forename: Chun-Feng
authors.initials: CF
authors.lastname: Li
authors.affiliation: Beijing Traditional Medicine Chinese Hospital, Capital Medical University.
authors.forename: Min
authors.initials: M
authors.lastname: Tian
authors.affiliation: Department of Virology, Beijing Institute of Microbiology and Epidemiology; Anhui Medical University, Hefei, China.
authors.forename: Jia-Nan
authors.initials: JN
authors.lastname: Hao
authors.affiliation: Department of Biochemistry and Molecular Biology, Department of Pharmacology and Toxicology , Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch , Galveston.
authors.forename: Xu-Ping
authors.initials: XP
authors.lastname: Xie
authors.affiliation: Department of Biochemistry and Molecular Biology, Department of Pharmacology and Toxicology , Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch , Galveston.
authors.forename: Pei-Yong
authors.initials: PY
authors.lastname: Shi
authors.affiliation: Department of Virology, Beijing Institute of Microbiology and Epidemiology; State Key Laboratory of Pathogen and Biosecurity, Beijing; Guangxi Medical University, Nanning; Anhui Medical University, Hefei, China.
authors.forename: Cheng-Feng
authors.initials: CF
authors.lastname: Qin
keywords: Zika virus; adenosine analog; antiviral; mouse model