title: Synthesis of polydopamine as a new and biocompatible coating of magnetic nanoparticles for delivery of doxorubicin in mouse breast adenocarcinoma.
abstract: OBJECTIVE
  Carrier-mediated drug delivery systems can be used to increase the intracellular concentration of drugs in cancerous cells, thereby improving drug biodistribution and minimizing unwanted side effects. This study aimed to investigate the effect of synthesized magnetic molecularly imprinted polydopamine for controlled doxorubicin (DOX) delivery in a breast adenocarcinoma model of BALB/c mice with an external magnetic field.
  
  
  METHODS
  The synthesized DOX-imprinted polydopamine (DOX-IP) was characterized using Fourier transform infrared spectroscopy and scanning electron microscopy. The efficacy of DOX-IP in tumor growth suppression was assessed in terms of tumor growth delay, tumor doubling time, inhibition ratio, and histopathology. High-performance liquid chromatography and flame atomic absorption spectrometry were performed to investigate the drug distribution among tissues.
  
  
  RESULTS
  The findings showed higher efficacy of DOX-IP with magnetic field in suppressing tumor growth than free DOX and DOX-IP without magnetic field. Significantly high DOX concentration in tumor tissue was found in the DOX-IP group with magnetic field.
  
  
  CONCLUSIONS
  Magnetic DOX-IP demonstrates effective tumor-targeted drug delivery in a mouse model of breast cancer.
authors.affiliation: School of Biology, Damghan University, Damghan, Iran. Zavareh.S@du.ac.ir.
authors.forename: Saeed
authors.initials: S
authors.lastname: Zavareh
authors.affiliation: Department of Chemistry, Damghan Branch, Islamic Azad University, Damghan, Iran.
authors.forename: Milad
authors.initials: M
authors.lastname: Mahdi
authors.affiliation: Department of Biohemistry, Damghan Branch, Islamic Azad University, Damghan, Iran.
authors.forename: Soheyla
authors.initials: S
authors.lastname: Erfanian
authors.affiliation: Department of Chemistry, Damghan Branch, Islamic Azad University, Damghan, Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Hashemi-Moghaddam
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis*; D003692:Delayed-Action Preparations; D004317:Doxorubicin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D004574:Electromagnetic Fields; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D015674:Mammary Neoplasms, Animal / Q000188:drug therapy* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D010316:Particle Size; D011108:Polymers / Q000138:chemical synthesis* / Q000494:pharmacology*; D013054:Spectrophotometry, Atomic; D017550:Spectroscopy, Fourier Transform Infrared; D016019:Survival Analysis; D014018:Tissue Distribution; D016896:Treatment Outcome
chemical_list: D000903:Antibiotics, Antineoplastic; D020099:Coated Materials, Biocompatible; D003692:Delayed-Action Preparations; D007211:Indoles; D058185:Magnetite Nanoparticles; D011108:Polymers; C568283:polydopamine; D004317:Doxorubicin
keywords: Breast adenocarcinoma; Doxorubicin; Imprinted polydopamine; Magnetic nanoparticle