title: Trace Element Status (Zinc, Copper, Selenium, Iron, Manganese) in Patients with Long-Term Home Parenteral Nutrition.
abstract: The objective of the present study was to determine concentrations of zinc (Zn), copper (Cu), iron (Fe), selenium (Se) in blood plasma and manganese (Mn) in the whole blood in patients with long-term home parenteral nutrition (HPN) in comparison to the control group.
  
  
  
  We examined 68 patients (16 men and 52 women) aged from 28 to 68 years on a long-term HPN lasting from 4 to 96 months. The short bowel syndrome was an indication for HPN. The daily doses of Zn, Cu, Fe, Se and Mn in the last 3 months were determined.
  
  
  
  No significant differences in blood plasma were found for Zn, Cu and Fe in patients with HPN and in the control group (p > 0.05). The concentration of Mn in whole blood was significantly increased in HPN patients (p < 0.0001), while Se concentration in these patients was significantly decreased (p < 0.005). The concentration of Mn in the whole blood of 16 patients with cholestasis was significantly increased compared to the patients without cholestasis (p < 0.001). The Cu concentration was increased with no statistical significance.
  
  
  
  In long-term HPN, the status of trace elements in the patients has to be continually monitored and the daily substitution doses of these elements have to be flexibly adjusted. Dosing schedule needs to be adjusted especially in cases of cholestatic hepatopathy. A discussion about the optimal daily dose of Mn in patients on HPN is appropriate. For clinical practice, the availability of a substitution mixture of trace elements lacking Mn would be advantageous.
authors.affiliation: Department of Gastroenterology and Internal Medicine, University Hospital Brno and Faculty of Medicine Masaryk University, Brno, Czech Republic.
authors.forename: Milan
authors.initials: M
authors.lastname: Dastych
authors.forename: Michal
authors.initials: M
authors.lastname: Šenkyřík
authors.forename: Milan
authors.initials: M
authors.lastname: Dastych
authors.forename: František
authors.initials: F
authors.lastname: Novák
authors.forename: Petr
authors.initials: P
authors.lastname: Wohl
authors.forename: Jan
authors.initials: J
authors.lastname: Maňák
authors.forename: Pavel
authors.initials: P
authors.lastname: Kohout
mesh_terms: D000328:Adult; D000368:Aged; D002780:Cholestasis, Intrahepatic / Q000150:complications; D003300:Copper / Q000032:analysis / Q000097:blood / Q000172:deficiency / Q000627:therapeutic use; D018153:Czech Republic / Q000453:epidemiology; D003677:Deficiency Diseases / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007501:Iron / Q000032:analysis / Q000097:blood / Q000627:therapeutic use; D000090463:Iron Deficiencies; D008297:Male; D008345:Manganese / Q000032:analysis / Q000097:blood / Q000172:deficiency / Q000627:therapeutic use; D008875:Middle Aged; D009752:Nutritional Status; D057947:Parenteral Nutrition Solutions / Q000737:chemistry; D016331:Parenteral Nutrition, Home / Q000009:adverse effects*; D015995:Prevalence; D012306:Risk; D012643:Selenium / Q000032:analysis / Q000097:blood / Q000172:deficiency / Q000627:therapeutic use; D012778:Short Bowel Syndrome / Q000097:blood / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D013997:Time Factors; D014131:Trace Elements / Q000032:analysis / Q000097:blood / Q000172:deficiency* / Q000627:therapeutic use; D015032:Zinc / Q000032:analysis / Q000097:blood / Q000172:deficiency / Q000627:therapeutic use
chemical_list: D057947:Parenteral Nutrition Solutions; D014131:Trace Elements; D008345:Manganese; D003300:Copper; D007501:Iron; D012643:Selenium; D015032:Zinc