title: α1-Blockers in Men with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Obstruction: Is Silodosin Different?
abstract: Available α1-blockers (ABs) have different profiles of receptor selectivity. Silodosin exhibits the highest selectivity for the α1Aadrenergic receptor. This pharmacological feature couples with a singular urodynamic and clinical profile. The magnitude of bladder outlet obstruction improvement in patients receiving silodosin is higher if compared to other ABs. From a clinical point of view, current evidence suggests an advantage in favor of silodosin in terms of nocturia improvement and cardiovascular safety. The incidence of ejaculatory dysfunction with silodosin is higher compared to other Abs.
authors.affiliation: Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Claus G
authors.initials: CG
authors.lastname: Roehrborn
authors.affiliation: Department of Urology, Hospital de São João, Porto, Portugal.|Department of Urology, Federico II University, Naples, Italy.
authors.forename: Francisco
authors.initials: F
authors.lastname: Cruz
authors.affiliation: Department of Renal, Urologic and Infectious Disease, Faculty of Medicine, University of Porto, Porto, Portugal. ferdinando-fusco@libero.it.
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Fusco
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D053158:Nocturia / Q000188:drug therapy*; D011470:Prostatic Hyperplasia / Q000188:drug therapy*; D001748:Urinary Bladder Neck Obstruction / Q000188:drug therapy*
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists
keywords: Alpha-blockers; Silodosin; Urology