title: Effect of high-frequency subthalamic neurostimulation on gait and freezing of gait in Parkinson's disease: a systematic review and meta-analysis.
abstract: The aim of this meta-analysis was to summarize the short- and long-term effects of bilateral deep brain stimulation of the subthalamic nucleus (STN-DBS) on gait and freezing of gait (FOG) in Parkinson's disease and to detect predictors of post-stimulation outcome. A comprehensive review of the literature was conducted up to October 2015 using Medline Ovid databases for studies analyzing the effect of bilateral STN-DBS on FOG and/or gait. Sixteen studies with available data for the gait item (no. 29) of the Unified Parkinson's Disease Rating Scale (UPDRS) and six studies with the FOG item (no. 14) were included. Data were summarized for the following follow-up periods: 6-15, 24-48 and >48 months. For the medication (Med)-Off/stimulation(Stim)-On condition compared with baseline Med-Off, STN-DBS significantly improved gait on average from 2.43 to 0.96, 2.53 to 1.31 and 2.56 to 1.40 points at 6-15, 24-48 and >48 months, respectively (P < 0.05). Pre-operative levodopa responsiveness of UPDRS-III and Med-Off severity of gait were the predictors of this beneficial effect. STN-DBS significantly improved FOG for the Med-Off/Stim-On condition compared with baseline on average from 2.26 to 0.82, 2.43 to 1.13 and 2.48 to 1.38 points at 6-15, 24-48 and >48 months, respectively (P < 0.05). There was no significant effect in the Med-On/Stim-On condition. This meta-analysis showed a robust improvement of gait and FOG by STN-DBS for more than 4 years in the Med-Off/Stim-On condition. No beneficial effect was found for the On state of medication. Pre-operative levodopa responsiveness of global motor performance (UPDRS-III) is the strongest predictor of the effect of deep brain stimulation on gait.
authors.affiliation: Department of Neurology, Christian-Albrechts-University, Kiel, Germany.
authors.forename: C
authors.identifier: 0000-0002-3838-6848
authors.initials: C
authors.lastname: Schlenstedt
authors.affiliation: Department of Neurology, Christian-Albrechts-University, Kiel, Germany.|Department of Neurology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
authors.forename: A
authors.initials: A
authors.lastname: Shalash
authors.affiliation: Department of Neurology, Christian-Albrechts-University, Kiel, Germany.|Department of Neurology, Johannes Gutenberg University, Mainz, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Muthuraman
authors.affiliation: Department of Neurosurgery, Christian-Albrechts-University, Kiel, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Falk
authors.affiliation: Department of Neurology, Christian-Albrechts-University, Kiel, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Witt
authors.affiliation: Department of Neurology, Christian-Albrechts-University, Kiel, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Deuschl
mesh_terms: D046690:Deep Brain Stimulation / Q000379:methods*; D005684:Gait; D020233:Gait Disorders, Neurologic / Q000209:etiology / Q000628:therapy*; D006801:Humans; D010300:Parkinson Disease / Q000150:complications / Q000628:therapy*; D020531:Subthalamic Nucleus; D016896:Treatment Outcome
keywords: Parkinson's disease; deep brain stimulation; freezing of gait; gait; meta-analysis; review; subthalamic nucleus