title: The relationship between serum total testosterone and free testosterone levels with serum hemoglobin and hematocrit levels: a study in 1221 men.
abstract: OBJECTIVE
  To investigate the relationship between serum total testosterone (TT) and free testosterone (FT) levels in men with anemia.
  
  
  METHODS
  We reviewed the records of 1221 subjects between March 2009 and December 2014. All the subjects' blood samples were drawn for TT and FT assays. Their serum hemoglobin (Hb) and serum hematocrit (Hct) levels were measured. The primary objective of our study was to investigate the association between TT and FT levels with Hb and Hct levels.
  
  
  RESULTS
  The mean age was 59.82 ± 12.71 years. The mean TT and FT levels were 4.54 ± 2.02 ng/mL and 10.63 ± 3.69 pg/mL, respectively. The mean Hb and Hct levels were 14.72 ± 1.34 g/dL and 43.11 ± 3.75%, respectively. Subjects with low TT (<2.35 ng/mL) had low Hb and Hct levels (p < 0.001, p < 0.001, respectively). TT was positively associated with FT, Hb, and Hct. TT and FT levels were significantly lower in older men.
  
  
  CONCLUSIONS
  Subjects with low TT and FT levels had low Hb and Hct levels. This suggests that TT and FT play a significant role in erythropoiesis. Testosterone replacement therapy may be effective in men with hypogonadism to reduce the incidence of anemia.
authors.affiliation: a Department of Urology , Chonbuk National University , Jeonju , Republic of Korea.|b Research Institute of Clinical Medicine of Chonbuk National University , Jeonju , Republic of Korea , and.|c Biomedical Research Institute of Chonbuk National University , Jeonju , Republic of Korea.
authors.forename: Yu Seob
authors.initials: YS
authors.lastname: Shin
authors.affiliation: a Department of Urology , Chonbuk National University , Jeonju , Republic of Korea.|b Research Institute of Clinical Medicine of Chonbuk National University , Jeonju , Republic of Korea , and.|c Biomedical Research Institute of Chonbuk National University , Jeonju , Republic of Korea.
authors.forename: Jae Hyung
authors.initials: JH
authors.lastname: You
authors.affiliation: a Department of Urology , Chonbuk National University , Jeonju , Republic of Korea.|b Research Institute of Clinical Medicine of Chonbuk National University , Jeonju , Republic of Korea , and.|c Biomedical Research Institute of Chonbuk National University , Jeonju , Republic of Korea.
authors.forename: Jai Seong
authors.initials: JS
authors.lastname: Cha
authors.affiliation: a Department of Urology , Chonbuk National University , Jeonju , Republic of Korea.|b Research Institute of Clinical Medicine of Chonbuk National University , Jeonju , Republic of Korea , and.|c Biomedical Research Institute of Chonbuk National University , Jeonju , Republic of Korea.
authors.forename: Jong Kwan
authors.initials: JK
authors.lastname: Park
mesh_terms: D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D006400:Hematocrit / Q000706:statistics & numerical data; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood; D013739:Testosterone / Q000097:blood*; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006454:Hemoglobins; D014280:Triglycerides; D013739:Testosterone; D002784:Cholesterol; D017430:Prostate-Specific Antigen
keywords: Anemia; free testosterone; hematocrit; hemoglobin; testosterone