title: Destabilization Mechanism of Ionic Surfactant on Curcumin Nanocrystal against Electrolytes.
abstract: We have successfully developed curcumin nanosuspension intended for oral delivery. The main purpose is to improve bioavailability through enhancing its solubility. The nanoparticles were stabilized using various stabilizers, including polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA), sodium carboxymethylcellulose (Na-CMC), d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS), and sodium dodecyl sulfate (SDS). The average diameter of particles, microscopic appearance, and sedimentation of each preparation was observed and compared. Each stabilizer demonstrated a different degree of inhibition of particle aggregation under electrolyte-containing simulated gastrointestinal (GIT) fluid. Non-ionic stabilizers (PVA, PVP, and TPGS) were shown to preserve the nanosuspension stability against electrolytes. In contrast, strong ionic surfactants such as SDS were found to be very sensitive to electrolytes. The results can provide useful information for the formulators to choose the most suitable stabilizers by considering the nature of stabilizers and physiological characteristics of the target site of the drug.
authors.affiliation: Pharmaceutics Research Group, School of Pharmacy, Bandung Institute of Technology, Bandung 40132, Indonesia. h_rachmawati@fa.itb.ac.id.|Research Center for Nanosciences and Nanotechnology, Bandung Institute of Technology, Bandung 40132, Indonesia. h_rachmawati@fa.itb.ac.id.
authors.forename: Heni
authors.initials: H
authors.lastname: Rachmawati
authors.affiliation: Research Center for Nanosciences and Nanotechnology, Bandung Institute of Technology, Bandung 40132, Indonesia. annisarahma@fa.itb.ac.id.
authors.forename: Annisa
authors.initials: A
authors.lastname: Rahma
authors.affiliation: Department of Pharmacy, Pharmaceutical Technology, Biopharmaceutics & NutriCosmetics, Freie Universität Berlin, Berlin 12169, Germany. losh79@gmail.com.
authors.forename: Loaye
authors.initials: L
authors.lastname: Al Shaal
authors.affiliation: Department of Pharmacy, Pharmaceutical Technology, Biopharmaceutics & NutriCosmetics, Freie Universität Berlin, Berlin 12169, Germany. nanoteam@gmx.com.
authors.forename: Rainer H
authors.initials: RH
authors.lastname: Müller
authors.affiliation: Department of Pharmacy, Pharmaceutical Technology, Biopharmaceutics & NutriCosmetics, Freie Universität Berlin, Berlin 12169, Germany. cornelia.keck@pharmazie.uni-marburg.de.
authors.forename: Cornelia M
authors.initials: CM
authors.lastname: Keck
keywords: curcumin; electrolyte; ionic surfactant; nanosuspension; particle aggregation; stabilizer