title: Treatment of climacteric symptoms with an ammonium succinate-based dietary supplement: a randomized, double-blind, placebo-controlled trial.
abstract: Peri- and postmenopausal women commonly suffer from climacteric symptoms. We evaluated the effectiveness and safety of dietary supplement Amberen to relieve vasomotor and psychosomatic symptoms during the course of a 3-month, randomized, double-blind, placebo-controlled study. General clinical assessment, evaluation using the Greene climacteric test and Spielberger-Hanin test, determination of plasma levels of gonadotropins, estradiol, leptin and apolipoproteins were used to evaluate 42-60-year-old women with vasomotor and psychosomatic menopausal symptoms. One hundred and twenty-five women were enrolled in the study and randomized between two groups. Based on the Greene test results, there was a statistically significant improvement (р < 0.05) in 13 out of 21 menopausal symptoms in women who took Amberen. During the course and by the end of the study, patients showed statistically significant changes in the levels of estradiol, gonadotropins and leptin, and decreases in body weight and waist circumference. Spielberger-Hanin test showed that Amberen stabilizes patients' psychological state with a statistically significant decrease in anxiety, increased stress resistance and improved adaptability. Comparative analysis of the vital signs measurements, blood tests and urinalysis did not show any negative effects of Amberen on the patients. Our findings indicate that Amberen can be considered a method of choice to relief mild/moderate climacteric symptoms.
authors.affiliation: a Department of Obstetrics and Gynecology , the Peoples' Friendship University of Russia, Medical Institute , Moscow , Russia.
authors.forename: V E
authors.initials: VE
authors.lastname: Radzinskii
authors.affiliation: b Women's Health Research Institute, Research Center, I.M. Sechenov First Moscow State Medical University , Moscow , Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Kuznetsova
authors.affiliation: b Women's Health Research Institute, Research Center, I.M. Sechenov First Moscow State Medical University , Moscow , Russia.
authors.forename: Y B
authors.initials: YB
authors.lastname: Uspenskaya
authors.affiliation: c Department of Obstetrics and Gynecology , Ryazan State Medical University named after academician I.P. Pavlov , Ryazan , Russia , and.
authors.forename: N B
authors.initials: NB
authors.lastname: Repina
authors.affiliation: c Department of Obstetrics and Gynecology , Ryazan State Medical University named after academician I.P. Pavlov , Ryazan , Russia , and.
authors.forename: Y K
authors.initials: YK
authors.lastname: Gusak
authors.affiliation: d Department of Therapy , M.V. Lomonosov Moscow State University , Moscow , Russia.
authors.forename: O M
authors.initials: OM
authors.lastname: Zubova
authors.affiliation: b Women's Health Research Institute, Research Center, I.M. Sechenov First Moscow State Medical University , Moscow , Russia.
authors.forename: D I
authors.initials: DI
authors.lastname: Burchakov
authors.affiliation: a Department of Obstetrics and Gynecology , the Peoples' Friendship University of Russia, Medical Institute , Moscow , Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Osmakova
mesh_terms: D000328:Adult; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008593:Menopause / Q000187:drug effects*; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use; D017063:Outcome Assessment, Health Care; D019802:Succinic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D014810:Vitamin E / Q000627:therapeutic use
chemical_list: D008903:Minerals; D014810:Vitamin E; D019802:Succinic Acid
keywords: Ammonium succinate; menopausal symptoms treatment; menopause; mitochondrial dysfunction; vasomotor and psychosomatic menopause symptoms