title: Association of lipoprotein subfractions with endothelial function and arterial stiffness in acute ischemic stroke.
abstract: Hypercholesterolemia represents a risk factor for the development of atherosclerosis. Lipoprotein research has recently been focused on the phenomenon of atherogenic and non-atherogenic lipoproteins. The aim of this study was to explore the association of lipoprotein subfractions with a measure for endothelial function (represented by reactive hyperemia index [RHI]) and arterial stiffness (represented by augmentation index [AI]) in patients with acute ischemic stroke. We enrolled 51 patients with acute ischemic stroke. Blood samples were obtained within 24 h after the stroke onset in a fasting condition. Electrophoresis method on polyacrylamide gel was used for the analysis of plasma lipoproteins. RHI and AI was measured by peripheral arterial tonometry (EndoPAT2000 device). We failed to find any significant correlation between RHI and baseline characteristics of the population. Significant correlation was found between AI and age, hypertension, low density lipoprotein cholesterol (LDL) 1, LDL 3-7, score for anti-atherogenic risk and atherogenic profile. Age (beta = .362, p = .006) and LDL1 (beta = -0.283, p = .031) were the only independent variables significantly associated with AI in regression analysis. Significantly higher AI was found in an atherogenic lipoprotein profile compared to a non-atherogenic profile population (median 25% vs. median 11.5%, p = .043). In conclusion, our results suggest significant inverse correlation between levels of LDL 1 subfraction and measures of AI in patients with acute ischemic stroke. Significantly higher values of AI were observed in the population with an atherogenic lipoprotein profile.
authors.affiliation: a 1st Department of Neurology , Comenius University , Bratislava , Slovakia.
authors.forename: Pavel
authors.initials: P
authors.lastname: Šiarnik
authors.affiliation: a 1st Department of Neurology , Comenius University , Bratislava , Slovakia.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Čarnická
authors.affiliation: b 2nd Department of Internal Medicine , Comenius University , Bratislava , Slovakia.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Krivošíková
authors.affiliation: a 1st Department of Neurology , Comenius University , Bratislava , Slovakia.
authors.forename: Katarína
authors.initials: K
authors.lastname: Klobučníková
authors.affiliation: c Department of Medical Chemistry, Biochemistry and Clinical Chemistry, Faculty of Medicine , Comenius University , Bratislava , Slovakia.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Žitňanová
authors.affiliation: a 1st Department of Neurology , Comenius University , Bratislava , Slovakia.
authors.forename: Branislav
authors.initials: B
authors.lastname: Kollár
authors.affiliation: a 1st Department of Neurology , Comenius University , Bratislava , Slovakia.|d Department of Neurology , St. Johns Hospital Vienna , Austria.
authors.forename: Marek
authors.initials: M
authors.lastname: Sýkora
authors.affiliation: a 1st Department of Neurology , Comenius University , Bratislava , Slovakia.
authors.forename: Peter
authors.initials: P
authors.lastname: Turčáni
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood* / Q000145:classification; D015243:Cholesterol, VLDL / Q000097:blood; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D006973:Hypertension / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D020521:Stroke / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D059289:Vascular Stiffness
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL
keywords: Acute stroke; arterial stiffness; atherosclerosis; low density lipoprotein; vascular risk factors