title: High specific activity is not optimal:18F-fluoroestradio positron emission tomography-computed tomography results in a breast cancer xenograft.
abstract: The purpose of the preliminary study was to investigate whether high specific activity (SA) of18F-fluoroestradiol was optimal in breast cancer diagnosis. Imaging at variable SA was conducted in a ZR-75-1 xenograft model of estrogen-receptor positive human breast cancer in 6 mice. The region of interest was manually drawn, and the percent of injected dose per gram of the tumor and muscle in the regions of interest were recorded. Tumor-to-muscle ratio (T/M) was calculated and compared in each group with different SAs. In addition, the correlation between blood estradiol and sex hormone-binding globulin and the value of T/M were also analyzed. The value of T/M increased initially with the rise of SA and it reached the peak at SA of 1.6 Ci/μmol. After that, the value fell down sharply and remained stable from SA of 3.1 Ci/μmol. The value of T/M was highest at SA of 1.6 Ci/μmol (P < .001). Additionally, the blood levels of estradiol and sex hormone-binding globulin showed no correlation with the value of T/M (P > .05). High SA of18F-fluoroestradiol leads to low T/M results in breast cancer xenograft models. We should control SA in a reasonable range to obtain high-quality images.
authors.affiliation: Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai, China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.|Center for Biomedical Imaging, Fudan University, Shanghai, China.|Shanghai Engineering Research Center of Molecular Imaging Probes, Shanghai, China.
authors.forename: Zhongyi
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai, China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.|Center for Biomedical Imaging, Fudan University, Shanghai, China.|Shanghai Engineering Research Center of Molecular Imaging Probes, Shanghai, China.
authors.forename: Huiyu
authors.initials: H
authors.lastname: Yuan
authors.affiliation: Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai, China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.|Center for Biomedical Imaging, Fudan University, Shanghai, China.|Shanghai Engineering Research Center of Molecular Imaging Probes, Shanghai, China.
authors.forename: Xiaoping
authors.identifier: 0000-0001-9656-6233
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai, China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.|Center for Biomedical Imaging, Fudan University, Shanghai, China.|Shanghai Engineering Research Center of Molecular Imaging Probes, Shanghai, China.
authors.forename: Bingxin
authors.initials: B
authors.lastname: Gu
authors.affiliation: Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai, China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.|Center for Biomedical Imaging, Fudan University, Shanghai, China.|Shanghai Engineering Research Center of Molecular Imaging Probes, Shanghai, China.
authors.forename: Mingwei
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai, China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.|Center for Biomedical Imaging, Fudan University, Shanghai, China.|Shanghai Engineering Research Center of Molecular Imaging Probes, Shanghai, China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai, China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.|Center for Biomedical Imaging, Fudan University, Shanghai, China.|Shanghai Engineering Research Center of Molecular Imaging Probes, Shanghai, China.
authors.forename: Yongping
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai, China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.|Center for Biomedical Imaging, Fudan University, Shanghai, China.|Shanghai Engineering Research Center of Molecular Imaging Probes, Shanghai, China.
authors.forename: Yingjian
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D045744:Cell Line, Tumor; D002471:Cell Transformation, Neoplastic; D004958:Estradiol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D005188:False Negative Reactions; D005260:Female; D005462:Fluorine Radioisotopes; D005916:Globulins / Q000378:metabolism; D006801:Humans; D051379:Mice; D009132:Muscles / Q000000981:diagnostic imaging / Q000378:metabolism; D000072078:Positron Emission Tomography Computed Tomography
chemical_list: D005462:Fluorine Radioisotopes; D005916:Globulins; C062756:1-fluoroestradiol; D004958:Estradiol
keywords: 18F-FES micro-PET/CT; breast cancer; nude mouse; specific activity