title: Gene expression data from acetaminophen-induced toxicity in human hepaticin vitrosystems and clinical liver samples.
abstract: This data set is composed of transcriptomics analyses of (i) liver samples from patients suffering from acetaminophen-induced acute liver failure (ALF) and (ii) hepatic cell systems exposed to acetaminophen and their respective controls. Thein vitrosystems include widely employed cell linesi.e.HepaRG and HepG2 cells as well as a novel stem cell-derived modeli.e.human skin-precursors-derived hepatocyte-like cells (hSKP-HPC). Data from primary human hepatocytes was also added to the data set "Open TG-GATEs: a large-scale toxicogenomics database" (Igarashi et al., 2015) [1]. Changes in gene expression due to acetaminophen intoxication as well as comparative information between humanin vivoandin vitrosamples are provided. The microarray data have been deposited in NCBI׳s Gene Expression Omnibus and are accessible through GEO Series accession number GEO: GSE74000. The provided data is used to evaluate the predictive capacity of each hepaticin vitrosystem and can be directly compared with large-scale publically available toxicogenomics databases. Further interpretation and discussion of these data feature in the corresponding research article "Toxicogenomics-based prediction of acetaminophen-induced liver injury using human hepatic cell systems" (Rodrigues et al., 2016) [2].
authors.affiliation: Department of in vitro Toxicology and Dermato-Cosmetology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
authors.forename: Robim M
authors.initials: RM
authors.lastname: Rodrigues
authors.affiliation: Translational Cell & Tissue Research Unit, Department of Imaging & Pathology, Katholieke Universiteit Leuven (KUL), Minderbroedersstraat 12, 3000 Leuven, Belgium.
authors.forename: Olivier
authors.initials: O
authors.lastname: Govaere
authors.affiliation: Translational Cell & Tissue Research Unit, Department of Imaging & Pathology, Katholieke Universiteit Leuven (KUL), Minderbroedersstraat 12, 3000 Leuven, Belgium.
authors.forename: Tania
authors.initials: T
authors.lastname: Roskams
authors.affiliation: Department of in vitro Toxicology and Dermato-Cosmetology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
authors.forename: Tamara
authors.initials: T
authors.lastname: Vanhaecke
authors.affiliation: Department of in vitro Toxicology and Dermato-Cosmetology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
authors.forename: Vera
authors.initials: V
authors.lastname: Rogiers
authors.affiliation: Department of in vitro Toxicology and Dermato-Cosmetology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
authors.forename: Joery
authors.initials: J
authors.lastname: De Kock
keywords: Acetaminophen; Liver toxicity; Transcriptomics; in vitro