title: Active haematological manifestations of systemic lupus erythematosus lupus are associated with a high rate of in-hospital mortality.
abstract: The aim of this study was to estimate the impact of the haematological manifestations of systemic lupus erythematosus (SLE) on mortality in hospitalized patients. For that purpose a case-control study of hospitalized patients in a medical referral centre from January 2009 to December 2014 was performed. For analysis, patients hospitalized for any haematological activity of SLE ( n = 103) were compared with patients hospitalized for other manifestations of SLE activity or complications of treatment ( n = 206). Taking as a variable outcome hospital death, an analysis of potential associated factors was performed. The most common haematological manifestation was thrombocytopenia (63.1%), followed by haemolytic anaemia (30%) and neutropenia (25.2%). In the group of haematological manifestations, 17 (16.5%) deaths were observed compared to 10 (4.8%) deaths in the control group ( P < 0.001). The causes of death were similar in both groups. In the analysis of the variables, it was found that only haematological manifestations were associated with intra-hospital death (odds ratio 3.87, 95% confidence interval 1.8-88, P < 0.001). Our study suggests that apparently any manifestation of haematological activity of SLE is associated with poor prognosis and contributes to increased hospital mortality.
authors.affiliation: 1 Rheumatology Department, Hospital de Especialidades Dr Antonio Fraga Mouret, Mexico City, Mexico.
authors.forename: D
authors.initials: D
authors.lastname: Miranda-Hernández
authors.affiliation: 1 Rheumatology Department, Hospital de Especialidades Dr Antonio Fraga Mouret, Mexico City, Mexico.
authors.forename: C
authors.initials: C
authors.lastname: Cruz-Reyes
authors.affiliation: 2 Hospital General Regional No. 1, Charo, Mexico.
authors.forename: C
authors.initials: C
authors.lastname: Monsebaiz-Mora
authors.affiliation: 3 Instituto de Investigación en Reumatología y del Sistema Músculo-esquelético, Universidad de Guadalajara, Guadalajara, Mexico.
authors.forename: E
authors.initials: E
authors.lastname: Gómez-Bañuelos
authors.affiliation: 4 Direction of Epidemiology, Hospital de Especialidades Dr Antonio Fraga Mouret, Mexico City, Mexico.
authors.forename: U
authors.initials: U
authors.lastname: Ángeles
authors.affiliation: 5 Direction of Education and Research, Hospital de Especialidades Dr Antonio Fraga Mouret, Mexico City, Mexico.
authors.forename: L J
authors.initials: LJ
authors.lastname: Jara
authors.affiliation: 1 Rheumatology Department, Hospital de Especialidades Dr Antonio Fraga Mouret, Mexico City, Mexico.
authors.forename: M Á
authors.initials: MÁ
authors.lastname: Saavedra
mesh_terms: D000328:Adult; D000743:Anemia, Hemolytic / Q000453:epidemiology* / Q000401:mortality; D016022:Case-Control Studies; D002460:Cell Line; D005260:Female; D017052:Hospital Mortality; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000401:mortality*; D008297:Male; D009503:Neutropenia / Q000453:epidemiology* / Q000401:mortality; D011379:Prognosis; D013921:Thrombocytopenia / Q000453:epidemiology* / Q000401:mortality; D055815:Young Adult
keywords: Systemic lupus erythematosus; haemolytic anaemia; mortality; neutropenia; thrombocytopenia