title: [Association between serum albumin and cognitive performance in elderly Chinese].
abstract: Objective:To explore association between serum albumin level and cognitive performance in elderly Chinese.Methods:All the subjects aged ≥65 years in the 8 longevity areas in Chinese longitudinal health longevity survey (CLHLS) were invited to participate the biomedical indepth CLHLS study, information about subjects' demographic characteristics, lifestyle, prevalence of diseases and health status was collected through household-interview. The cognitive performance was assessed with Mini Mental State Evaluation (MMSE) scale. Health examination was conducted by medical personnel and fasting venous blood samples were collected to detect the levels of triglycerides, total cholesterol, fasting glucose, creatine and blood albumin. MMSE score was compared and the trend was analyzed with generalized linear model. Association between albumin concentration and cognitive impairment was analyzed by logistic regression model.Results:Generalized linear model showed that adjusted MMSE score increased from 23.22 in the lowest quartile group to 25.07 in the highest quartile group (Pfor linear trend <0.001). Logistic regression analysis results showed that the higher albumin level was associated with the lower risk of cognitive impairment (P< 0.001), theORdecreased linearly with the increasing level of albumin (P<0.01), with theOR(95%CI) for the lower, higher and highest quartile groups was 0.64(0.45-0.91), 0.60(0.40-0.89) and 0.43(0.27-0.69), respectively, compared with the lowest quartile group.Conclusion:High level of serum albumin was associated with low risk of cognitive impairment.
authors.affiliation: Division of Non-communicable Diseases Control and Community Health, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
authors.forename: Z X
authors.initials: ZX
authors.lastname: Yin
authors.affiliation: Division of Non-communicable Diseases Control and Community Health, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
authors.forename: J L
authors.initials: JL
authors.lastname: Wang
authors.affiliation: Beijing Entry-exit Inspection and Quarantine Bureau, Beijing 100026, China.
authors.forename: Y B
authors.initials: YB
authors.lastname: Lyu
authors.affiliation: Division of Non-communicable Diseases Control and Community Health, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
authors.forename: J S
authors.initials: JS
authors.lastname: Luo
authors.affiliation: Center for Study of Healthy Aging and Development Studies, National School of Development, Peking University, Beijing 100871, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zeng
authors.affiliation: Institute of Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
authors.forename: X M
authors.initials: XM
authors.lastname: Shi
mesh_terms: D000368:Aged; D044466:Asian People; D002784:Cholesterol; D003071:Cognition; D003072:Cognition Disorders; D005260:Female; D006306:Health Surveys; D006801:Humans; D016014:Linear Models; D016015:Logistic Models; D008136:Longevity; D008137:Longitudinal Studies; D008297:Male; D015995:Prevalence; D012709:Serum Albumin; D014280:Triglycerides
chemical_list: D012709:Serum Albumin; D014280:Triglycerides; D002784:Cholesterol