title: Intersectin scaffold proteins and their role in cell signaling and endocytosis.
abstract: Intersectins (ITSNs) are a family of multi-domain proteins involved in regulation of diverse cellular pathways. These scaffold proteins are well known for regulating endocytosis but also play important roles in cell signaling pathways including kinase regulation and Ras activation. ITSNs participate in several human cancers, such as neuroblastomas and glioblastomas, while their downregulation is associated with lung injury. Alterations in ITSN expression have been found in neurodegenerative diseases such as Down Syndrome and Alzheimer's disease. Binding proteins for ITSNs include endocytic regulatory factors, cytoskeleton related proteins (i.e. actin or dynamin), signaling proteins as well as herpes virus proteins. This review will summarize recent studies on ITSNs, highlighting the importance of these scaffold proteins in the aforementioned processes.
authors.affiliation: Department of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA; Jesse Brown VA Medical Center, Chicago, IL 60612, USA.
authors.forename: Erika
authors.initials: E
authors.lastname: Herrero-Garcia
authors.affiliation: Department of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA; Jesse Brown VA Medical Center, Chicago, IL 60612, USA. Electronic address: obryanj@uic.edu.
authors.forename: John P
authors.initials: JP
authors.lastname: O'Bryan
mesh_terms: D033942:Adaptor Proteins, Vesicular Transport / Q000235:genetics* / Q000378:metabolism; D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D000818:Animals; D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D003598:Cytoskeletal Proteins / Q000235:genetics* / Q000378:metabolism; D004314:Down Syndrome / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D004705:Endocytosis / Q000235:genetics*; D005786:Gene Expression Regulation; D005909:Glioblastoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D006801:Humans; D055370:Lung Injury / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D009447:Neuroblastoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D015689:Oncogene Protein p21(ras) / Q000235:genetics / Q000378:metabolism; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D033942:Adaptor Proteins, Vesicular Transport; D003598:Cytoskeletal Proteins; D020033:Protein Isoforms; C115919:intersectin 1; D011494:Protein Kinases; D015689:Oncogene Protein p21(ras)
keywords: Actin; Cancer; Endocytosis; Intersectin; Neurons; Scaffold