title: Metastasis of Mammary Gland Malignant Phyllodes Tumor to the Mandibular Region: A Case Report and Review of the Literature.
abstract: Phyllodes tumor is a rare breast tumor described by Müller (1938) as a lesion comprising leaflike stromal fibrous components and narrow cysts. The frequency of distant metastasis from this entity is reportedly approximately 20%, and no effective therapy has been established, so the prognosis is poor. This report describes the case of a 60-year-old woman with a history of left lung resection who showed metastasis of a mammary gland malignant phyllodes tumor to the oral cavity. Intraoral examination showed an elastic, hard mass measuring 28 × 27 mm in the gingiva around the left mandibular second molar. Biopsy examination showed growth of giant cells and roughly circular cells showing positivity for S-100, p63, and vimentin on immunohistochemical staining. The authors diagnosed metastasis of the mammary gland malignant phyllodes tumor to the left mandible and performed cyber knife irradiation (44 Gy in 5 fractions) of the left mandible. The mass in the oral cavity disappeared after cyber knife irradiation, but the patient died of direct invasion to the spine.
authors.affiliation: Assistant Professor, Showa University Northern Yokohama Hospital, Dentistry and Oral Surgery, Kanagawa; Department of Oral and Maxillofacial Surgery, Showa University School of Dentistry, Tokyo, Japan. Electronic address: yoshiba@dent.showa-u.ac.jp.
authors.forename: Sayaka
authors.initials: S
authors.lastname: Yoshiba
authors.affiliation: Department Head, Department of Medical Oncology, Matsudo City Hospital, Chiba, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Saotome
authors.affiliation: Lecturer, Department of Clinico-Diagnostic Pathology, Showa University Northern Yokohama Hospital, Diagnostic Pathology, Kanagawa, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Mikogami
authors.affiliation: Professor, Department of Oral and Maxillofacial Surgery, Showa University School of Dentistry, Tokyo, Japan.
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Shirota
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D005887:Gingival Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008339:Mandibular Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D008875:Middle Aged; D003557:Phyllodes Tumor / Q000473:pathology* / Q000601:surgery; D011859:Radiography; D014057:Tomography, X-Ray Computed