title: Within- and Across-Sex Inheritance of Bone Microarchitecture.
abstract: The maternal heritability of bone microarchitecture according to the sex of the offspring is not known.
  
  
  
  To explore sex difference and influence of mother's menopausal status on the heritability of bone microarchitecture between mothers and their offspring.
  
  
  
  In 102 mother-daughter and 161 mother-son pairs, volumetric bone mineral density (BMD) and bone microarchitecture were measured at the distal radius and tibia by high-resolution peripheral quantitative computed tomography. A principal components analysis was applied for the radius and the tibia volumetric BMD and microarchitecture parameters separately. Two components, a trabecular one and a cortical one were identified at the radius and tibia. Half heritability (½h2) was estimated as the slope of the regression between offspring and mothers for each bone parameter separately.
  
  
  
  The mean age (± standard deviation) of mothers and daughters was 50.6 ± 4.1 years and 20.4 ± 0.5 years, respectively; that of mothers and sons was 45.8 ± 3.9 years and 15.2 ± 0.5 years, respectively. Most trabecular and cortical parameters were inherited in both mother-daughter and mother-son pairs (β = 0.15 to 0.33; P = 0.05 to 0.001). At the tibia, trabecular and cortical principal components were significantly inherited in both sexes, whereas only the trabecular one was inherited at the radius (½h2, 21% to 35%). There was no difference in heritability of bone microarchitecture between mother-daughter and mother-son pairs. All heritabilities remained after adjustment for age, weight, height, gonadal status, and areal BMD (½h2, 9% to 25%). In the mother-daughter pairs, there was no systematic drop of heritability across menopause.
  
  
  
  Volumetric bone density and microarchitecture are highly and similarly inherited between and within sexes. The genetic effects remain predominant across menopause.
authors.affiliation: Division of Bone Diseases, University Hospitals and Faculty of Medicine, CH-1205, Geneva, Switzerland.|Department of Internal Medicine and Medical Disciplines, "Sapienza" University of Rome, Rome, 00161, Italy; and.
authors.forename: Jessica
authors.initials: J
authors.lastname: Pepe
authors.affiliation: Division of Bone Diseases, University Hospitals and Faculty of Medicine, CH-1205, Geneva, Switzerland.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Biver
authors.affiliation: Division of Bone Diseases, University Hospitals and Faculty of Medicine, CH-1205, Geneva, Switzerland.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Bonnet
authors.affiliation: Division of Bone Diseases, University Hospitals and Faculty of Medicine, CH-1205, Geneva, Switzerland.|Division of Geriatrics, Department of Internal Medicine, Rehabilitation and Geriatrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
authors.forename: François R
authors.initials: FR
authors.lastname: Herrmann
authors.affiliation: Division of Bone Diseases, University Hospitals and Faculty of Medicine, CH-1205, Geneva, Switzerland.
authors.forename: René
authors.initials: R
authors.lastname: Rizzoli
authors.affiliation: Division of Bone Diseases, University Hospitals and Faculty of Medicine, CH-1205, Geneva, Switzerland.
authors.forename: Thierry
authors.initials: T
authors.lastname: Chevalley
authors.affiliation: Division of Bone Diseases, University Hospitals and Faculty of Medicine, CH-1205, Geneva, Switzerland.
authors.forename: Serge Livio
authors.initials: SL
authors.lastname: Ferrari
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D000328:Adult; D015519:Bone Density / Q000502:physiology*; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000502:physiology*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D040582:Inheritance Patterns; D008297:Male; D008875:Middle Aged; D009035:Mothers; D009679:Nuclear Family; D011379:Prognosis; D012727:Sex Characteristics; D014057:Tomography, X-Ray Computed / Q000379:methods; D055815:Young Adult