title: Host genetics role in the pathogenesis of periodontal disease and caries.
abstract: BACKGROUND
  This study aimed to produce the latest summary of the evidence for association of host genetic variants contributing to both periodontal diseases and caries.
  
  
  METHODS
  Two systematic searches of the literature were conducted in Ovid Medline, Embase, LILACS and Cochrane Library for large candidate gene studies (CGS), systematic reviews and genome-wide association studies reporting data on host genetic variants and presence of periodontal disease and caries.
  
  
  RESULTS
  A total of 124 studies were included in the review (59 for the periodontitis outcome and 65 for the caries outcome), from an initial search of 15,487 titles. Gene variants associated with periodontitis were categorized based on strength of evidence and then compared with gene variants associated with caries. Several gene variants showed moderate to strong evidence of association with periodontitis, although none of them had also been associated with the caries trait.
  
  
  CONCLUSIONS
  Despite some potential aetiopathogenic similarities between periodontitis and caries, no genetic variants to date have clearly been associated with both diseases. Further studies or comparisons across studies with large sample size and clear phenotype definition could shed light into possible shared genetic risk factors for caries and periodontitis.
authors.affiliation: Centre for Oral Clinical Research, Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Queen Mary University London (QMUL), London, UK.
authors.forename: Luigi
authors.initials: L
authors.lastname: Nibali
authors.affiliation: Library Services, UCL Eastman Dental Institute, London, UK.
authors.forename: Anna
authors.initials: A
authors.lastname: Di Iorio
authors.affiliation: Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
authors.forename: Yu-Kang
authors.identifier: http://orcid.org/0000-0002-2461-474X
authors.initials: YK
authors.lastname: Tu
authors.affiliation: Department of Oral Biology, University of Pittsburgh School of Dental Medicine, Pittsburgh, PA, USA.
authors.forename: Alexandre R
authors.initials: AR
authors.lastname: Vieira
mesh_terms: D003731:Dental Caries / Q000235:genetics*; D006801:Humans; D010510:Periodontal Diseases / Q000235:genetics*
keywords: caries; genetic; periodontitis