title: Elevated serum concentrations of lipopolysaccharide binding protein might prolong sleep stage one in middle-aged hypertensive males.
abstract: OBJECTIVE
  Sleep architecture can be affected by alteration in circulating lipopolysaccaride and cytokines. However, still unknown are the effects of lipopolysaccaride-binding protein (LBP) on sleep architecture. Therefore, potential relationship between alteration in serum LBP concentrations and sleep architecture was analyzed.
  
  
  METHODS
  This is a cross-sectional study. Consecutive 54 hypertensive males, aged 30-65 years. and with no obstructive sleep apnea via polysomnography, were recruited. Subjects were divided into two groups via the LBP median as hypertensives with higher and lower serum LBP (n = 27 and n = 27, respectively). Sleep architecture was assessed by polysomnography. Serum LBP, IL-1β, IL-6, and TNF-α were measured by commercial laboratories using sandwich-type enzyme immunoassay kit.
  
  
  RESULTS
  Hypertensive subjects with higher LBP showed significantly higher inflammatory status as assessed by IL-1β (18.85 ± 3.71 vs 16.15 ± 4.00 ng/L, P = 0.009), IL-6 (67.64 ± 11.22 vs 58.94 ± 11.32 ng/L, P = 0.004), and TNF-α (322.27 ± 59.17 vs 283.89 ± 61.87 pg/ml, P = 0.024) than did those with lower LBP. Hypertensives with higher serum LBP also exhibited prolonged N1 % (7.63 ± 3.55 vs 4.98 ± 2.90 %, P = 0.002), the transition from wakefulness to other sleep stages or follows arousal during sleep, than did those with lower LBP. A significant positive correlation was observed between serum LBP concentrations and N1 % (r = 0.378, P = 0.005) via Spearman's correlation and remained significant even after adjusting for age, apnea-hypopnea index, and body mass index.
  
  
  CONCLUSIONS
  Elevation in serum concentrations of LBP might prolong N1 % in this middle-aged hypertensive males, which needs to be confirmed further.
authors.affiliation: The Center of Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region; The Center of Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91 Tianchi Road, Tianshan District Urumqi, Xinjiang, 830001, China.
authors.forename: Mulalibieke
authors.initials: M
authors.lastname: Heizhati
authors.affiliation: The Center of Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region; The Center of Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91 Tianchi Road, Tianshan District Urumqi, Xinjiang, 830001, China. lnanfang2010@sina.com.
authors.forename: Nanfang
authors.initials: N
authors.lastname: Li
authors.affiliation: The Center of Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region; The Center of Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91 Tianchi Road, Tianshan District Urumqi, Xinjiang, 830001, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Shao
authors.affiliation: The Center of Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region; The Center of Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91 Tianchi Road, Tianshan District Urumqi, Xinjiang, 830001, China.
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Yao
authors.affiliation: The Center of Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region; The Center of Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91 Tianchi Road, Tianshan District Urumqi, Xinjiang, 830001, China.
authors.forename: Yingchun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: The Center of Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region; The Center of Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91 Tianchi Road, Tianshan District Urumqi, Xinjiang, 830001, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Hong
authors.affiliation: The Center of Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region; The Center of Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91 Tianchi Road, Tianshan District Urumqi, Xinjiang, 830001, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhou
authors.affiliation: The Center of Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region; The Center of Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91 Tianchi Road, Tianshan District Urumqi, Xinjiang, 830001, China.
authors.forename: Delian
authors.initials: D
authors.lastname: Zhang
authors.affiliation: The Center of Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region; The Center of Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91 Tianchi Road, Tianshan District Urumqi, Xinjiang, 830001, China.
authors.forename: Guijuan
authors.initials: G
authors.lastname: Chang
authors.affiliation: The Center of Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region; The Center of Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91 Tianchi Road, Tianshan District Urumqi, Xinjiang, 830001, China.
authors.forename: Suofeiya
authors.initials: S
authors.lastname: Abulikemu
mesh_terms: D000209:Acute-Phase Proteins; D000328:Adult; D000368:Aged; D002352:Carrier Proteins / Q000097:blood*; D003430:Cross-Sectional Studies; D006801:Humans; D006973:Hypertension / Q000097:blood*; D018836:Inflammation Mediators / Q000097:blood; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D008875:Middle Aged; D017286:Polysomnography; D012894:Sleep Stages / Q000502:physiology*; D013223:Statistics as Topic; D014851:Wakefulness / Q000502:physiology; D000099231:Lipopolysaccharide-Binding Protein
chemical_list: D000209:Acute-Phase Proteins; D002352:Carrier Proteins; D018836:Inflammation Mediators; D008562:Membrane Glycoproteins; D000099231:Lipopolysaccharide-Binding Protein
keywords: Hypertension; Inflammatory mediators; Males; Sleep stages