title: Psychiatric comorbidity and plasma levels of 2-acyl-glycerols in outpatient treatment alcohol users. Analysis of gender differences.
abstract: Alcohol addiction is associated with high psychiatric comorbidity. Objective stratification of patients is necessary to optimize care and improve prognosis. The present study is designed to gain insights into this challenge by addressing the following objectives: a) to estimate the prevalence of psychiatric comorbidities in a sample of outpatients seeking treatment for alcohol use disorder, b) to describe the existence of gender differences and c) to validate 2-acyl-glycerols as biomarkers of alcohol use disorder and/or psychiatric comorbidity. One hundred and sixty-two patients were recruited and evaluated with the semi-structured interview PRISM. The presence of psychopathology was associated with a greater number of criteria for alcohol abuse and dependence according to DSM-IV-TR. We found gender differences in psychiatric comorbidity, e.g., mood disorder, as well as in comorbid substance use disorders. The prevalence of lifetime psychiatric comorbidity was 68.5%, with mood disorders the most frequent (37%), followed by attention deficit disorder (24.7%) and anxiety disorders (17.9%). Substance-induced disorders were more frequent in mood and psychotic disorders, whereas the primary disorders were more prevalent in patients with comorbid anxiety disorders. We found that 2-acyl-glycerols were significantly decreased in comorbid anxiety disorders in alcohol dependent patients in the last year, which makes them a potential biomarker for this psychopathological condition.
authors.affiliation: IBIMA, Hospital Regional Universitario de Málaga; Red de Trastornos Adictivos, Instituto de Salud Carlos III.. ngarciamarchena@gmail.com.
authors.forename: Nuria
authors.initials: N
authors.lastname: García Marchena
authors.forename: Pedro
authors.initials: P
authors.lastname: Araos
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Pavón
authors.forename: Guillermo
authors.initials: G
authors.lastname: Ponce
authors.forename: María
authors.initials: M
authors.lastname: Pedraz
authors.forename: Antonia
authors.initials: A
authors.lastname: Serrano
authors.forename: Francisco
authors.initials: F
authors.lastname: Arias
authors.forename: Pablo
authors.initials: P
authors.lastname: Romero-Sanchiz
authors.forename: Juan
authors.initials: J
authors.lastname: Suárez
authors.forename: Antoni
authors.initials: A
authors.lastname: Pastor
authors.forename: Rafael
authors.initials: R
authors.lastname: De la Torre
authors.forename: Marta
authors.initials: M
authors.lastname: Torrens
authors.forename: Gabriel
authors.initials: G
authors.lastname: Rubio
authors.forename: Fernando
authors.initials: F
authors.lastname: Rodríguez de Fonseca
mesh_terms: D000437:Alcoholism / Q000097:blood* / Q000150:complications / Q000628:therapy; D000553:Ambulatory Care; D005260:Female; D005989:Glycerides / Q000097:blood*; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000150:complications / Q000453:epidemiology; D008875:Middle Aged; D015995:Prevalence; D012737:Sex Factors
chemical_list: D005989:Glycerides