title: Antibacterial and antifouling properties of a polyurethane surface modified with perfluoroalkyl and silver nanoparticles.
abstract: Inspired by mussel-adhesion phenomena in nature, a simple, mild surface modification process was elaborated to endow the polyurethane (PU) substrate with antibacterial/antifouling properties. In the present study, polydopamine was coated directly onto polyurethane surfaces. AgNO3was then added and absorbed onto the surface by the active catechol and amine groups of the polydopamine coating. Meanwhile, the adsorbed Ag+ions were reduced in situ into metallic silver nanoparticles by the "bridge" of the polydopamine coating which yielded a coating with good antimicrobial properties. Finally, 1H, 1H, 2H, 2H-perfluorodecanethiol (CF3(CF2)7CH2CH2SH, F-SH) was attached on the PDA coating via the Michael addition reaction. The hydrophobic F-SH layer above the antibacterial layer yielded a surface with excellent antifouling properties. Preliminary antibacterial assays indicate that the coated surfaces show enhanced antibacterial activity against Escherichia coli (Gram-negative bacteria) and Staphylococcus aureus (Gram-positive bacteria). Platelet adhesion was significantly reduced for the F-SH-coated PU film. These results suggest that the modified PU could be used as an antibacterial material for future biomedical applications. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 531-538, 2017.
authors.affiliation: College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu, 610041, China.
authors.forename: Deqiu
authors.initials: D
authors.lastname: Xu
authors.affiliation: College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu, 610041, China.
authors.forename: Yuling
authors.initials: Y
authors.lastname: Su
authors.affiliation: College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu, 610041, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Zhao
authors.affiliation: College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu, 610041, China.
authors.forename: Fancui
authors.initials: F
authors.lastname: Meng
authors.affiliation: College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu, 610041, China.
authors.forename: Chang
authors.initials: C
authors.lastname: Liu
authors.affiliation: College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu, 610041, China.
authors.forename: Yayuan
authors.initials: Y
authors.lastname: Guan
authors.affiliation: College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu, 610041, China.
authors.forename: Jiya
authors.initials: J
authors.lastname: Zhang
authors.affiliation: College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu, 610041, China.
authors.forename: Jianbin
authors.initials: J
authors.lastname: Luo
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001792:Blood Platelets / Q000378:metabolism; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology; D005466:Fluorocarbons / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D010973:Platelet Adhesiveness / Q000187:drug effects; D011140:Polyurethanes / Q000737:chemistry / Q000494:pharmacology; D012834:Silver / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000254:growth & development*
chemical_list: D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D005466:Fluorocarbons; D011140:Polyurethanes; D012834:Silver
keywords: antibacterial; antifouling; polydopamine; polyurethane; surface modification