title: Application of radiofrequency thermocoagulation combined with adriamycin injection in dorsal root ganglia for controlling refractory pain induced by rib metastasis of lung cancer (a STROBE-compliant article).
abstract: This study aimed to observe the therapeutic effects and adverse reactions of radiofrequency thermocoagulation combined with adriamycin injection in dorsal root ganglia on lung cancer rib metastasis-related refractory pain which has no response to conventional therapy.This study contained 27 patients with lung cancer rib metastasis-related moderate or severe pain which had no response to conventional therapy. Under computed tomography (CT)-guidance, radiofrequency puncture need reached the corresponding intervertebral foramens to ensure needle point near dorsal root ganglia (DRG) by sensory and motor stimulation tests, and then radiofrequency thermocoagulation was performed on each corresponding DRG followed by injection of 0.5 to 1 mL of adriamycin (0.5%). The conditions of pain and complications were observed before management and 3 days, 1 month, and 3 months after management, respectively.Numerical rating scale (NRS) scores and dosage of morphine were all significantly decreased after management as compared with those before management (all P < 0.01). Although the number of patients with chest wall numbness was significantly increased after management as compared with that before management (all P < 0.01), the degree of chest wall numbness was tolerable. There were no statistical differences between before and after management in nausea and vomiting, and constipation.CT-guided radiofrequency thermocoagulation combined with adriamycin injection in DRG can effectively control lung cancer rib metastasis-related pain which has no response to conventional therapy. This combinatory treatment regimen is featured by better therapeutic effects and a few complications, so it is worthy of being recommended in clinical application.
authors.affiliation: Doctor on-the-job of the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China Department of Pain, Henan Provincial Tumor Hospital, Zhengzhou, China Department of Anesthesiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Guang-Lun
authors.initials: GL
authors.lastname: Xie
authors.forename: Da-Peng
authors.initials: DP
authors.lastname: Guo
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Li
authors.forename: Chang
authors.initials: C
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000556:secondary* / Q000628:therapy; D000072716:Cancer Pain / Q000209:etiology / Q000628:therapy*; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use*; D004564:Electrocoagulation; D005260:Female; D005727:Ganglia, Spinal; D006801:Humans; D007278:Injections, Spinal; D008175:Lung Neoplasms / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010148:Intractable Pain / Q000209:etiology / Q000628:therapy; D061208:Pulsed Radiofrequency Treatment; D012272:Ribs
chemical_list: D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin