title: Does Decorin Protect Neuronal Tissue via Its Antioxidant and Antiinflammatory Activity from Traumatic Brain Injury? An Experimental Study.
abstract: BACKGROUND
  The development of secondary brain injury via oxidative stress after traumatic brain injury (TBI) is well known. Decorin (DC) inactivates transforming growth factor β1, complement system, and tumor necrosis factor α, which are related to oxidative stress and apoptosis. Consequently, the aim of the present study was to evaluate the role of DC on TBI.
  
  
  METHODS
  A total of 24 male rats were used and divided into 4 groups as follows; control, trauma, DC, and methylprednisolone (MP). The trauma, DC, and MP groups were subjected to closed-head contusive weight-drop injuries. Rats received treatment with intraperitoneal saline, DC, or MP, respectively. All the animals were killed at the 24th hour after trauma and brain tissues were extracted. The oxidant/antioxidant parameters (malondialdehyde, glutathione peroxidase, superoxide dismutase, and NO) and caspase 3 in the cerebral tissue were analyzed, and histomorphologic evaluation of the cerebral tissue was performed.
  
  
  RESULTS
  Levels of malondialdehyde, NO, and activity of caspase 3 were significantly reduced, and in addition glutathione peroxidase and superoxide dismutase levels were increased in the DC and MP groups compared with the trauma group. The pathology scores and the percentage of degenerated neurons were statistically lower in the DC and MP groups than in the trauma group.
  
  
  CONCLUSIONS
  The results of the present study showed that DC inactivates transforming growth factor β1 and protects the brain tissue and neuronal cells after TBI.
authors.affiliation: Ministry of Health Diskapi Yildirim Beyazit Training and Research Hospital, Neurosurgery Clinic, Ankara, Turkey. Electronic address: rftozay@hotmail.com.
authors.forename: Rafet
authors.initials: R
authors.lastname: Özay
authors.affiliation: Ministry of Health Diskapi Yildirim Beyazit Training and Research Hospital, Neurosurgery Clinic, Ankara, Turkey.
authors.forename: Erhan
authors.initials: E
authors.lastname: Türkoğlu
authors.affiliation: Ministry of Health Fatih Sultan Mehmet Training and Research Hospital, Neurosurgery Clinic, İstanbul, Turkey.
authors.forename: Bora
authors.initials: B
authors.lastname: Gürer
authors.affiliation: Ministry of Health Diskapi Yildirim Beyazit Training and Research Hospital, Neurosurgery Clinic, Ankara, Turkey.
authors.forename: Habibullah
authors.initials: H
authors.lastname: Dolgun
authors.affiliation: Department of Histology and Embryology, Ankara University Faculty of Medicine, Ankara, Turkey.
authors.forename: Oya
authors.initials: O
authors.lastname: Evirgen
authors.affiliation: Department of Biochemistry, Ankara University Faculty of Medicine, Ankara, Turkey.
authors.forename: Berrin İmge
authors.initials: Bİ
authors.lastname: Ergüder
authors.affiliation: Department of Histology and Embryology, Ankara University Faculty of Medicine, Ankara, Turkey.
authors.forename: Nazlı
authors.initials: N
authors.lastname: Hayırlı
authors.affiliation: Ministry of Health Diskapi Yildirim Beyazit Training and Research Hospital, Neurosurgery Clinic, Ankara, Turkey.
authors.forename: Levent
authors.initials: L
authors.lastname: Gürses
authors.affiliation: Ministry of Health Diskapi Yildirim Beyazit Training and Research Hospital, Neurosurgery Clinic, Ankara, Turkey.
authors.forename: Zeki
authors.initials: Z
authors.lastname: Şekerci
authors.affiliation: Ministry of Health Diskapi Yildirim Beyazit Training and Research Hospital, Neurosurgery Clinic, Ankara, Turkey.
authors.forename: Erdal Reşit
authors.initials: ER
authors.lastname: Yılmaz
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology; D000070642:Brain Injuries, Traumatic / Q000188:drug therapy* / Q000276:immunology* / Q000473:pathology; D002470:Cell Survival / Q000187:drug effects; D016207:Cytokines / Q000276:immunology; D058575:Decorin / Q000008:administration & dosage* / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000187:drug effects* / Q000276:immunology* / Q000473:pathology; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D016207:Cytokines; D058575:Decorin; D018696:Neuroprotective Agents; D017382:Reactive Oxygen Species
keywords: Antioxidants; Apoptosis; Decorin; Methylprednisolone; Neuroprotection; Traumatic brain injury