title: Effect of maternal zinc supplementation on the cardiometabolic profile of Peruvian children: results from a randomized clinical trial.
abstract: Zinc is an essential micronutrient for the development of the fetal renal, cardiovascular and metabolic systems; however, there is limited evidence of its effects on the postnatal cardiometabolic function. In this study, we evaluated the effect of maternal zinc supplementation during pregnancy on the cardiometabolic profile of the offspring in childhood. A total of 242 pregnant women were randomly assigned to receive a daily supplement containing iron+folic acid with or without zinc. A follow-up study was conducted when children of participating mothers were 4.5 years of age to evaluate their cardiometabolic profile, including anthropometric measures of body size and composition, blood pressure, lipid profile and insulin resistance. No difference in measures of child cardiometabolic risk depending on whether mothers received supplemental zinc during pregnancy. Our results do not support the hypothesis that maternal zinc supplementation reduces the risk of offspring cardiometabolic disease.
authors.affiliation: 1Kasiska School of Health Professions,Idaho State University,Pocatello,ID,USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Mispireta
authors.affiliation: 2Department of International Health,Center for Human Nutrition,Johns Hopkins Bloomberg School of Public Health,Baltimore,MD,USA.
authors.forename: L E
authors.initials: LE
authors.lastname: Caulfield
authors.affiliation: 4Instituto de Investigación Nutricional,Lima,Peru.
authors.forename: N
authors.initials: N
authors.lastname: Zavaleta
authors.affiliation: 5Global Health Division,Becton Dickinson, Franklin Lakes,NJ,USA.
authors.forename: M
authors.initials: M
authors.lastname: Merialdi
authors.affiliation: 6Eunice Kennedy ShriverNational Institute of Child Health and Human Development,National Institutes of Health,Bethesda,MD,USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Putnick
authors.affiliation: 6Eunice Kennedy ShriverNational Institute of Child Health and Human Development,National Institutes of Health,Bethesda,MD,USA.
authors.forename: M H
authors.initials: MH
authors.lastname: Bornstein
authors.affiliation: 3Department of Population, Family and Reproductive Health,Johns Hopkins Bloomberg School of Public Health,Baltimore,MD,USA.
authors.forename: J A
authors.initials: JA
authors.lastname: DiPietro
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D002648:Child; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D024821:Metabolic Syndrome / Q000453:epidemiology*; D010568:Peru / Q000453:epidemiology; D011247:Pregnancy; D055815:Young Adult; D015032:Zinc / Q000008:administration & dosage*
chemical_list: D015032:Zinc
keywords: cardiovascular; metabolic; zinc