title: Condensation of anthranilic acids with pyridines to furnish pyridoquinazolones via pyridine dearomatization.
abstract: The unprecedented carbodiimide-mediated condensation between pyridines and anthranilic acids via pyridine dearomatization at room temperature has been developed to provide a straightforward approach to pyridoquinazolones. The value of this approach has further been demonstrated by its application to one-step, gram-scale syntheses of a series of pyridoquinazolone-based natural products and their analogues from readily available starting materials.
authors.affiliation: State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, and Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. xdp@imm.ac.cn.
authors.forename: Yajun
authors.initials: Y
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Yangqiao West Road 155, Fuzhou, Fujian 350002, China. wpsu@fjirsm.ac.cn.
authors.forename: Cuiju
authors.initials: C
authors.lastname: Zhu
authors.affiliation: State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Yangqiao West Road 155, Fuzhou, Fujian 350002, China. wpsu@fjirsm.ac.cn.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Yangqiao West Road 155, Fuzhou, Fujian 350002, China. wpsu@fjirsm.ac.cn.
authors.forename: Shijun
authors.initials: S
authors.lastname: Huang
authors.affiliation: State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, and Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. xdp@imm.ac.cn.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Lin
authors.affiliation: State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, and Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. xdp@imm.ac.cn.
authors.forename: Xiandao
authors.initials: X
authors.lastname: Pan
authors.affiliation: State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Yangqiao West Road 155, Fuzhou, Fujian 350002, China. wpsu@fjirsm.ac.cn.
authors.forename: Weiping
authors.initials: W
authors.lastname: Su