title: Molecular Control of Actin Dynamics In Vivo: Insights from Drosophila.
abstract: The actin cytoskeleton provides mechanical support for cells and generates forces to drive cell shape changes and cell migration in morphogenesis. Molecular understanding of actin dynamics requires a genetically traceable model system that allows interdisciplinary experimental approaches to elucidate the regulatory network of cytoskeletal proteins in vivo. Here, we will discuss some examples of how advances in Drosophila genetics and high-resolution imaging techniques contribute to the discovery of new actin functions, signaling pathways, and mechanisms of actin regulation in vivo.
authors.affiliation: Institute for Neurobiology, University of Muenster, Badestrasse 9, 48149, Muenster, Germany.
authors.forename: Lena
authors.initials: L
authors.lastname: Brüser
authors.affiliation: Institute for Neurobiology, University of Muenster, Badestrasse 9, 48149, Muenster, Germany. sbogdan@uni-muenster.de.
authors.forename: Sven
authors.initials: S
authors.lastname: Bogdan
mesh_terms: D008841:Actin Cytoskeleton / Q000502:physiology*; D000818:Animals; D002465:Cell Movement; D004330:Drosophila / Q000502:physiology*; D006801:Humans; D053612:Janus Kinases / Q000502:physiology; D008264:Macrophages / Q000502:physiology; D050791:STAT Transcription Factors / Q000502:physiology; D015398:Signal Transduction; D051300:Wiskott-Aldrich Syndrome Protein Family / Q000502:physiology
chemical_list: D050791:STAT Transcription Factors; C114864:WASF1 protein, human; D051300:Wiskott-Aldrich Syndrome Protein Family; D053612:Janus Kinases
keywords: Actin cytoskeleton; Boder cell migration; Cell migration; Drosophila; Egg chamber rotation; High-resolution microscopy; Live imaging; Macrophages; WASP proteins