title: Mechanism and early intervention research on ALI during emergence surgery of Stanford type-A AAD: Study protocol for a prospective, double-blind, clinical trial.
abstract: BACKGROUND
  Stanford type-A acute aortic dissection (AAD) is a severe cardiovascular disease demonstrating the characteristics of acute onset and rapid development, with high morbidity and mortality. The available evidence shows that preoperative acute lung injury (ALI) induced by Stanford type-A AAD is a frequent and important cause for a number of untoward consequences. However, there is no study assessing the incidence of preoperative ALI and its independent determinants before Standford type-A AAD surgery in Chinese adult patients.
  
  
  METHODS
  This is a prospective, double-blind, signal-center clinical trial. We will recruit 130 adult patients undergoing Stanford type-A AAD surgery. The incidence of preoperative ALI will be evaluated. Perioperative clinical baselines and serum variables including coagulation, fibrinolysis, inflammatory, reactive oxygen species, and endothelial cell function will be assayed. The independent factors affecting the occurrence of preoperative ALI will be identified by multiple logistic regression analysis.
  
  
  BACKGROUND
  ClinicalTrials.gov (https://register.clinicaltrials.gov/), Registration number NCT01894334.
authors.affiliation: Department of Anesthesiology Department of Cardiology Department of Epidemiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Cheng
authors.forename: Mu
authors.initials: M
authors.lastname: Jin
authors.forename: Xiuhua
authors.initials: X
authors.lastname: Dong
authors.forename: Lizhong
authors.initials: L
authors.lastname: Sun
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Rong
authors.initials: R
authors.lastname: Wang
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Yang
authors.forename: Peirong
authors.initials: P
authors.lastname: Lin
authors.forename: Siyu
authors.initials: S
authors.lastname: Hou
authors.forename: Yuehua
authors.initials: Y
authors.lastname: Ma
authors.forename: Yuefeng
authors.initials: Y
authors.lastname: Wang
authors.forename: Xudong
authors.initials: X
authors.lastname: Pan
authors.forename: Jiakai
authors.initials: J
authors.lastname: Lu
authors.forename: Weiping
authors.initials: W
authors.lastname: Cheng
mesh_terms: D000208:Acute Disease; D055371:Acute Lung Injury / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000784:Aortic Dissection / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D017545:Aortic Aneurysm, Thoracic / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D002681:China / Q000453:epidemiology; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D017052:Hospital Mortality / Q000639:trends; D006801:Humans; D015994:Incidence; D007431:Intraoperative Complications / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D014656:Vascular Surgical Procedures / Q000009:adverse effects*; D055815:Young Adult