title: Tripartite Motif 16 Inhibits the Migration and Invasion in Ovarian Cancer Cells.
abstract: Tripartite motif 16 (TRIM16), a member of the RING B-box coiled-coil (RBCC)/tripartite motif (TRIM) protein family, has been shown to play a role in tumor development and progression. However, the role of TRIM16 in ovarian cancer has never been revealed. Thus, in this study, we investigated the roles and mechanisms of TRIM16 in ovarian cancer. Our results demonstrated that TRIM16 expression was low in ovarian cancer cell lines. In addition, overexpression of TRIM16 significantly inhibited the migration and invasion in vitro, as well as suppressed the epithelial-mesenchymal transition (EMT) phenotype in ovarian cancer cells. Furthermore, overexpression of TRIM16 greatly inhibited the protein expression levels of Shh, Smo, Ptc, Gli-1, MMP2, and MMP9 in ovarian cancer cells. Taken together, these results strongly suggest that TRIM16 inhibits the migration and invasion via suppressing the Sonic hedgehog signaling pathway in ovarian cancer cells. Thus, TRIM16 may be a novel potential therapeutic target for ovarian cancer.
authors.affiliation: Department of Gynecology, Northwest Women and Children's Hospital, Xi'an, Shaanxi, P.R. China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Tan
authors.affiliation: Department of Gynecology, Northwest Women and Children's Hospital, Xi'an, Shaanxi, P.R. China.
authors.forename: Jin
authors.initials: J
authors.lastname: Qi
authors.affiliation: Department of Gynecology, Northwest Women and Children's Hospital, Xi'an, Shaanxi, P.R. China.
authors.forename: Guanghua
authors.initials: G
authors.lastname: Chu
authors.affiliation: Department of Gynecology, Northwest Women and Children's Hospital, Xi'an, Shaanxi, P.R. China.
authors.forename: Zhaoyang
authors.initials: Z
authors.lastname: Liu
mesh_terms: D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics; D005260:Female; D015870:Gene Expression; D053823:Hedgehog Proteins / Q000378:metabolism; D006801:Humans; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D000070584:Tripartite Motif Proteins; D044767:Ubiquitin-Protein Ligases
chemical_list: D004268:DNA-Binding Proteins; D053823:Hedgehog Proteins; D014157:Transcription Factors; D000070584:Tripartite Motif Proteins; C117731:TRIM16 protein, human; D044767:Ubiquitin-Protein Ligases