title: Can Adiponectin Help us to Target Diastolic Dysfunction?
abstract: Adiponectin is the most abundant adipokine and exhibits anti-inflammatory, antiatherogenic and antidiabetic properties. Unlike other adipokines, it inversely correlates with body weight and obesity-linked cardiovascular complications. Diastolic dysfunction is the main mechanism responsible for approximately half of all heart failure cases, the so-called heart failure with preserved ejection fraction (HFpEF), but therapeutic strategies specifically directed towards these patients are still lacking. In the last years, a link between adiponectin and diastolic dysfunction has been suggested. There are several mechanisms through which adiponectin may prevent most of the pathophysiologic mechanisms underlying diastolic dysfunction and HFpEF, including the prevention of myocardial hypertrophy, cardiac fibrosis, nitrative and oxidative stress, atherosclerosis and inflammation, while promoting angiogenesis. Thus, understanding the mechanisms underlying adiponectin-mediated improvement of diastolic function has become an exciting field of research, making adiponectin a promising therapeutic target. In this review, we explore the relevance of adiponectin signaling for the prevention of diastolic dysfunction and identify prospective therapeutic targets aiming at the treatment of this clinical condition.
authors.affiliation: Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Alameda Hernâni Monteiro, 4200-319, Porto, Portugal.
authors.forename: Catarina
authors.initials: C
authors.lastname: Francisco
authors.affiliation: Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Alameda Hernâni Monteiro, 4200-319, Porto, Portugal.|Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar São João, Alameda Hernâni Monteiro, 4200-319, Porto, Portugal.
authors.forename: João Sérgio
authors.initials: JS
authors.lastname: Neves
authors.affiliation: Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Alameda Hernâni Monteiro, 4200-319, Porto, Portugal.
authors.forename: Inês
authors.initials: I
authors.lastname: Falcão-Pires
authors.affiliation: Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Alameda Hernâni Monteiro, 4200-319, Porto, Portugal. amoreira@med.up.pt.
authors.forename: Adelino
authors.initials: A
authors.lastname: Leite-Moreira
mesh_terms: D052242:Adiponectin / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D050197:Atherosclerosis; D003971:Diastole / Q000502:physiology*; D006331:Heart Diseases / Q000503:physiopathology*; D006801:Humans; D018919:Neovascularization, Physiologic; D018384:Oxidative Stress
chemical_list: D052242:Adiponectin
keywords: Adipokine; Adiponectin; Diastolic dysfunction; Heart failure with preserved ejection fraction; Obesity