title: A review study on the effect of Iranian herbal medicines againstin vitroreplication of herpes simplex virus.
abstract: OBJECTIVE
  There are a number of published data indicatingin vitroanti-HSV activity of some of Iranian herbal extracts with no systematic review to discuss these results. Therefore, this article was aimed to review and discuss the methods carried out and the phytochemistry and bioactivity of the extracts used and also conclusions provided in these publications.
  
  
  METHODS
  Published articles both in English (from Medline, Science Direct, EMBASE, Scopus, Pro Quest, Google scholar, Cochrane Library) and in Persian (from SID, Iran Medex and Magiran) databases, from 1966 to October 2014 were incorporated in this review. Thein vitrostudies that lacked CC50, IC50, were excluded.
  
  
  RESULTS
  Only 42 published reports were found to examine Iranian herbs against HSV replicationin vitro.Seventeen out of 42 studies in which 23 kinds of medicinal plants were subjected to crude extraction were included. The review of data showed that some of the herbal extracts includingHyssopus officinalismethanolic extract,Melissa officinalisaqueous extract,Quercus persicaL. hydroalcoholic extract andSecurigeras ecuridacamethanolic extract with selective index (SI) of 234, 877, >778 and 250, respectively were highly effective against HSVin vitro.
  
  
  CONCLUSIONS
  More comprehensive studies using more advanced methods are needed to be done to achieve promising anti-HSV agents from the bioactive compounds isolated from these herbs.
authors.affiliation: Students Research Committee, Shahrekord University of Medical Science, Shahrekord, Iran.
authors.forename: Mohammad-Taghi
authors.initials: MT
authors.lastname: Moradi
authors.affiliation: Medical Plants Research Center, Shahrekord University of Medical Science, Shahrekord, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Rafieian-Kopaei
authors.affiliation: Medical Plants Research Center, Shahrekord University of Medical Science, Shahrekord, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Karimi
keywords: Herbal medicine; Herpes Simplex Virus; Iran In-vitro