title: Predicting Readmission at Early Hospitalization Using Electronic Clinical Data: An Early Readmission Risk Score.
abstract: Identifying patients at high risk for readmission early during hospitalization may aid efforts in reducing readmissions. We sought to develop an early readmission risk predictive model using automated clinical data available at hospital admission.
  
  
  
  We developed an early readmission risk model using a derivation cohort and validated the model with a validation cohort. We used a published Acute Laboratory Risk of Mortality Score as an aggregated measure of clinical severity at admission and the number of hospital discharges in the previous 90 days as a measure of disease progression. We then evaluated the administrative data-enhanced model by adding principal and secondary diagnoses and other variables. We examined the c-statistic change when additional variables were added to the model.
  
  
  
  There were 1,195,640 adult discharges from 70 hospitals with 39.8% male and the median age of 63 years (first and third quartile: 43, 78). The 30-day readmission rate was 11.9% (n=142,211). The early readmission model yielded a graded relationship of readmission and the Acute Laboratory Risk of Mortality Score and the number of previous discharges within 90 days. The model c-statistic was 0.697 with good calibration. When administrative variables were added to the model, the c-statistic increased to 0.722.
  
  
  
  Automated clinical data can generate a readmission risk score early at hospitalization with fair discrimination. It may have applied value to aid early care transition. Adding administrative data increases predictive accuracy. The administrative data-enhanced model may be used for hospital comparison and outcome research.
authors.affiliation: *Medical Informatics, Becton, Dickinson and Company †The Biomedical Informatics Research Center at San Diego State University, San Diego, CA ‡Harvard Medical School and Brigham and Women's Hospital, Boston, MA.
authors.forename: Ying P
authors.initials: YP
authors.lastname: Tabak
authors.forename: Xiaowu
authors.initials: X
authors.lastname: Sun
authors.forename: Carlos M
authors.initials: CM
authors.lastname: Nunez
authors.forename: Vikas
authors.initials: V
authors.lastname: Gupta
authors.forename: Richard S
authors.initials: RS
authors.lastname: Johannes
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019937:Diagnostic Techniques and Procedures / Q000706:statistics & numerical data*; D057286:Electronic Health Records / Q000706:statistics & numerical data; D005260:Female; D006739:Hospital Administration / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D010343:Patient Admission / Q000706:statistics & numerical data*; D010359:Patient Readmission / Q000706:statistics & numerical data*; D015203:Reproducibility of Results; D018570:Risk Assessment; D012307:Risk Factors; D012959:Socioeconomic Factors; D013997:Time Factors