title: Non-Enzymatic Glucose Sensing Using Carbon Quantum Dots Decorated with Copper Oxide Nanoparticles.
abstract: Perturbations in glucose homeostasis is critical for human health, as hyperglycemia (defining diabetes) leads to premature death caused by macrovascular and microvascular complications. However, the simple and accurate detection of glucose in the blood at low cost remains a challenging task, although it is of great importance for the diagnosis and therapy of diabetic patients. In this work, carbon quantum dots decorated with copper oxide nanostructures (CQDs/Cu₂O) are prepared by a simple hydrothermal approach, and their potential for electrochemical non-enzymatic glucose sensing is evaluated. The proposed sensor exhibits excellent electrocatalytic activity towards glucose oxidation in alkaline solutions. The glucose sensor is characterized by a wide concentration range from 6 µM to 6 mM, a sensitivity of 2.9 ± 0.2 µA·µM-1·cm-2, and a detection limit of 6 µM at a signal-to-noise ratio S/N = 3. The sensors are successfully applied for glucose determination in human serum samples, demonstrating that the CQDs/Cu₂O-based glucose sensor satisfies the requirements of complex sample detection with adapted potential for therapeutic diagnostics.
authors.affiliation: Institut d'Electronique, de Microélectronique et de Nanotechnologie (IEMN), UMR CNRS8520, Université Lille 1, Avenue Poincaré-BP 60069, 59652 Villeneuve d'Ascq, France. houcemmaaoui@gmail.com.|Département de Physique, Faculté des Sciences de Tunis, Université Tunis-El Manar, 2092 Tunis, Tunisia. houcemmaaoui@gmail.com.
authors.forename: Houcem
authors.initials: H
authors.lastname: Maaoui
authors.affiliation: Institut d'Electronique, de Microélectronique et de Nanotechnologie (IEMN), UMR CNRS8520, Université Lille 1, Avenue Poincaré-BP 60069, 59652 Villeneuve d'Ascq, France. fteodorescu@icf.ro.
authors.forename: Florina
authors.initials: F
authors.lastname: Teodoresu
authors.affiliation: Institut d'Electronique, de Microélectronique et de Nanotechnologie (IEMN), UMR CNRS8520, Université Lille 1, Avenue Poincaré-BP 60069, 59652 Villeneuve d'Ascq, France. qian1.wang@ed.univ-lille1.fr.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Luminescence and Applications, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, 3888 Dong Nanhu Road, 130033 Changchun, China. pangh@ciomp.ac.cn.
authors.forename: Guo-Hui
authors.initials: GH
authors.lastname: Pan
authors.affiliation: Unité Matériaux et transformations (UMET), UMR CNRS 8207, Université Lille1, Cité Scientifique, 59655 Villeneuve d'Ascq, France. ahmed.addad@univ-lille1.fr.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Addad
authors.affiliation: Département de Physique, Faculté des Sciences de Tunis, Université Tunis-El Manar, 2092 Tunis, Tunisia. radhouane.chtourou@inrst.rnrt.tn.
authors.forename: Radhouane
authors.initials: R
authors.lastname: Chtourou
authors.affiliation: Institut d'Electronique, de Microélectronique et de Nanotechnologie (IEMN), UMR CNRS8520, Université Lille 1, Avenue Poincaré-BP 60069, 59652 Villeneuve d'Ascq, France. sabine.szunerits@univ-lille1.fr.
authors.forename: Sabine
authors.initials: S
authors.lastname: Szunerits
authors.affiliation: Institut d'Electronique, de Microélectronique et de Nanotechnologie (IEMN), UMR CNRS8520, Université Lille 1, Avenue Poincaré-BP 60069, 59652 Villeneuve d'Ascq, France. rabah.boukherroub@iemn.univ-lille1.fr.
authors.forename: Rabah
authors.initials: R
authors.lastname: Boukherroub
keywords: carbon quantum dots; copper oxide nanoparticles; electrochemistry; glucose sensing; non-enzymatic; serum