title: A 'photorelease, catch and photorelease' strategy for bioconjugation utilizing a p-hydroxyphenacyl group.
abstract: A bioorthogonal 'catch and photorelease' strategy, which combines alkyne-azide cycloaddition between p-hydroxyphenacyl azide and alkyne derivatives to form a 1,2,3-triazole adduct and subsequent photochemical release of the triazole moiety via a photo-Favorskii rearrangement, is introduced. The first step can also involve photorelease of a strained alkyne and its Cu-free click reaction with azide.
authors.affiliation: Department of Chemistry and RECETOX, Faculty of Science, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic. slanina.tomas@seznam.cz klan@sci.muni.cz.
authors.forename: D
authors.initials: D
authors.lastname: Madea
authors.affiliation: Department of Chemistry and RECETOX, Faculty of Science, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic. slanina.tomas@seznam.cz klan@sci.muni.cz.
authors.forename: T
authors.initials: T
authors.lastname: Slanina
authors.affiliation: Department of Chemistry and RECETOX, Faculty of Science, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic. slanina.tomas@seznam.cz klan@sci.muni.cz.
authors.forename: P
authors.identifier: http://orcid.org/0000-0001-6287-2742
authors.initials: P
authors.lastname: Klán