title: Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy.
abstract: Antiretroviral drug therapy (ART) effectively suppresses replication of both the immunodeficiency viruses, human (HIV) and simian (SIV); however, virus rebounds soon after ART is withdrawn. SIV-infected monkeys were treated with a 90-day course of ART initiated at 5 weeks post infection followed at 9 weeks post infection by infusions of a primatized monoclonal antibody against the α4β7integrin administered every 3 weeks until week 32. These animals subsequently maintained low to undetectable viral loads and normal CD4+T cell counts in plasma and gastrointestinal tissues for more than 9 months, even after all treatment was withdrawn. This combination therapy allows macaques to effectively control viremia and reconstitute their immune systems without a need for further therapy.
authors.affiliation: Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: Siddappa N
authors.initials: SN
authors.lastname: Byrareddy
authors.affiliation: Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD 20892, USA.
authors.forename: James
authors.initials: J
authors.lastname: Arthos
authors.affiliation: Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD 20892, USA.
authors.forename: Claudia
authors.initials: C
authors.lastname: Cicala
authors.affiliation: Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. Division of Pathology, The Yerkes National Primate Center of Emory University, Atlanta, GA 30329, USA.
authors.forename: Francois
authors.initials: F
authors.lastname: Villinger
authors.affiliation: Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: Kristina T
authors.initials: KT
authors.lastname: Ortiz
authors.affiliation: Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: Dawn
authors.initials: D
authors.lastname: Little
authors.affiliation: Department of Obstetrics and Gynecology, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: Neil
authors.initials: N
authors.lastname: Sidell
authors.affiliation: Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA.
authors.forename: Maureen A
authors.initials: MA
authors.lastname: Kane
authors.affiliation: Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA.
authors.forename: Jianshi
authors.initials: J
authors.lastname: Yu
authors.affiliation: Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA.
authors.forename: Jace W
authors.initials: JW
authors.lastname: Jones
authors.affiliation: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30680, USA.
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Santangelo
authors.affiliation: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30680, USA.
authors.forename: Chiara
authors.initials: C
authors.lastname: Zurla
authors.affiliation: Centre for the AIDS Program of Research in South Africa (CAPRISA), Durban, South Africa.
authors.forename: Lyle R
authors.initials: LR
authors.lastname: McKinnon
authors.affiliation: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Kelly B
authors.initials: KB
authors.lastname: Arnold
authors.affiliation: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Caroline E
authors.initials: CE
authors.lastname: Woody
authors.affiliation: Primate Genetics Laboratory, German Primate Center, Leibniz Institute for Primate Research, Göttingen, Germany.
authors.forename: Lutz
authors.initials: L
authors.lastname: Walter
authors.affiliation: Primate Genetics Laboratory, German Primate Center, Leibniz Institute for Primate Research, Göttingen, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Roos
authors.affiliation: Primate Genetics Laboratory, German Primate Center, Leibniz Institute for Primate Research, Göttingen, Germany.
authors.forename: Angela
authors.initials: A
authors.lastname: Noll
authors.affiliation: Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD 20892, USA.
authors.forename: Donald
authors.initials: D
authors.lastname: Van Ryk
authors.affiliation: Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD 20892, USA.
authors.forename: Katija
authors.initials: K
authors.lastname: Jelicic
authors.affiliation: Division of Rheumatology, Johns Hopkins School of Medicine, Baltimore, MD 21201, USA.
authors.forename: Raffaello
authors.initials: R
authors.lastname: Cimbro
authors.affiliation: Division of Pathology, The Yerkes National Primate Center of Emory University, Atlanta, GA 30329, USA.
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Gumber
authors.affiliation: Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: Michelle D
authors.initials: MD
authors.lastname: Reid
authors.affiliation: Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: Volkan
authors.initials: V
authors.lastname: Adsay
authors.affiliation: Division of Pathology, The Yerkes National Primate Center of Emory University, Atlanta, GA 30329, USA.
authors.forename: Praveen K
authors.initials: PK
authors.lastname: Amancha
authors.affiliation: Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: Ann E
authors.initials: AE
authors.lastname: Mayne
authors.affiliation: Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: Tristram G
authors.initials: TG
authors.lastname: Parslow
authors.affiliation: Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD 20892, USA.
authors.forename: Anthony S
authors.initials: AS
authors.lastname: Fauci
authors.affiliation: Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. pathaaa@emory.edu.
authors.forename: Aftab A
authors.initials: AA
authors.lastname: Ansari
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D003131:Combined Modality Therapy; D016207:Cytokines / Q000097:blood; D004195:Disease Models, Animal; D005260:Female; D041981:Gastrointestinal Tract / Q000276:immunology; D007116:Immunization, Passive / Q000379:methods*; D007262:Infusions, Intravenous; D039441:Integrin alpha4 / Q000276:immunology*; D039641:Integrin beta Chains / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology; D008253:Macaca mulatta; D008297:Male; D008562:Membrane Glycoproteins / Q000276:immunology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000097:blood / Q000188:drug therapy / Q000628:therapy* / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000276:immunology* / Q000302:isolation & purification; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014212:Tretinoin / Q000097:blood; D014759:Viral Envelope Proteins / Q000276:immunology; D019562:Viral Load / Q000276:immunology; D014766:Viremia / Q000097:blood / Q000188:drug therapy / Q000628:therapy* / Q000821:virology
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D016207:Cytokines; D039641:Integrin beta Chains; D008562:Membrane Glycoproteins; D014759:Viral Envelope Proteins; C069623:gp120 protein, Simian immunodeficiency virus; C091368:integrin beta7; D039441:Integrin alpha4; D014212:Tretinoin; C543529:vedolizumab