title: Measurement properties of patient-reported outcome measures (PROMs) used in adult patients with chronic kidney disease: a systematic review protocol.
abstract: Chronic kidney disease (CKD) is associated with symptoms that can significantly reduce the quality of life (QoL) of patients. Patient-reported outcome measures (PROMs) may facilitate the assessment of the impact of disease and treatment on the QoL, from a patient perspective. PROMs can be used in research and routine clinical practice.
  
  
  
  A systematic review of studies evaluating the measurement properties of PROMs in adults with CKD will be conducted. MEDLINE, EMBASE, PsycINFO and CINAHL Plus will be systematically searched from inception. Hand searching of reference lists and citations of included studies will be carried out. 2 reviewers will independently screen the titles and abstracts of all the studies retrieved during the systematic search to determine their eligibility. The COnsensus-based Standards for the selection of health Measurement Instruments (COSMIN) checklist will be used to appraise the methodological quality of the selected studies following the full-text review. Data on the study population, questionnaire characteristics and measurement properties will be extracted from the selected papers. Finally, a narrative synthesis of extracted data will be undertaken.
  
  
  
  Ethical permissions are not required for this study as data from published research articles will be used. Findings will be disseminated through publication in a peer-reviewed journal and presented at conferences. This systematic review will provide a comprehensive assessment of the measurement properties of PROMs currently available for use in adult patients with CKD and present evidence which may inform the selection of measures for use in research and clinical practice.
  
  
  
  CRD42016035554.
authors.affiliation: Centre for Patient Reported Outcomes Research, University of Birmingham, Birmingham, UK Institute of Applied Health Research, University of Birmingham, Birmingham, UK.
authors.forename: Olalekan Lee
authors.initials: OL
authors.lastname: Aiyegbusi
authors.affiliation: Centre for Patient Reported Outcomes Research, University of Birmingham, Birmingham, UK Institute of Applied Health Research, University of Birmingham, Birmingham, UK.
authors.forename: Derek
authors.initials: D
authors.lastname: Kyte
authors.affiliation: Centre for Patient Reported Outcomes Research, University of Birmingham, Birmingham, UK University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital Birmingham, Birmingham, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Cockwell
authors.affiliation: Centre for Patient Reported Outcomes Research, University of Birmingham, Birmingham, UK Institute of Applied Health Research, University of Birmingham, Birmingham, UK.
authors.forename: Tom
authors.initials: T
authors.lastname: Marshall
authors.affiliation: Centre for Patient Reported Outcomes Research, University of Birmingham, Birmingham, UK Institute of Applied Health Research, University of Birmingham, Birmingham, UK.
authors.forename: Thomas
authors.initials: T
authors.lastname: Keeley
authors.affiliation: Oxford Policy Management Ltd, Level 3 Clarendon Centre, Oxford, UK.
authors.forename: Adrian
authors.initials: A
authors.lastname: Gheorghe
authors.affiliation: Centre for Patient Reported Outcomes Research, University of Birmingham, Birmingham, UK Institute of Applied Health Research, University of Birmingham, Birmingham, UK.
authors.forename: Melanie
authors.identifier: 0000-0002-1856-837X
authors.initials: M
authors.lastname: Calvert
mesh_terms: D000328:Adult; D057189:Checklist; D016208:Databases, Factual; D006801:Humans; D000071066:Patient Reported Outcome Measures; D011788:Quality of Life; D006435:Renal Dialysis / Q000523:psychology / Q000706:statistics & numerical data*; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology / Q000523:psychology / Q000628:therapy*; D011795:Surveys and Questionnaires; D000078202:Systematic Reviews as Topic; D006113:United Kingdom / Q000453:epidemiology
keywords: chronic kidney disease; measurement properties; patient-reported outcome measures; psychometric property; quality of life