title: Assessment of Combined Ascorbyl Palmitate (AP) and Sodium Ascorbyl Phosphate (SAP) on Facial Skin Sebum Control in Female Healthy Volunteers.
abstract: The skin is fortified with a setup of lipophilic and hydrophilic, enzymatic and non-enzymatic antioxidant systems. Ascorbyl palmitate (AP) and sodium ascorbyl phosphate (SAP) are reported as lipophilic and hydrophilic antioxidants, respectively used for skin care. Present study was aimed to assess the combined AP (in oil phase) and SAP (in aqueous phase) via multiple emulsion (ME1) for controlling sebum secretions in healthy human females. FTIR analysis of AP and SAP was performed for identification. Multiple emulsions (ME1and control) were prepared and analyzed for physical stability. Antioxidant activities of AP, SAP as well as ME1(with combination of these compounds) were determined by DPPH method. 11 female volunteers were included in a single-blinded, placebo-controlled, split-face comparative study. Volunteers were instructed to apply ME1on left cheek while control (without AP and SAP) on right cheek, for a period of 90 days. A non-invasive photometric device (Sebumeter®) was used for the measurement of sebum secretions on both sides of the face with subsequent time intervals. A good antioxidant activity of ME1was observed. ME1treatments reduced significant facial sebum secretions as compared with control/placebo treatments. It was concluded that combined AP and SAP supplementations to skin proved a promising choice for controlling facial sebum secretions and could be evaluated for undesired oily skin and acne reductions for beautifying the facial appearance.
authors.affiliation: Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, the Islamia University of Bahawalpur, Bahawalpur, Pakistan.
authors.forename: H
authors.initials: H
authors.lastname: Khan
authors.affiliation: Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, the Islamia University of Bahawalpur, Bahawalpur, Pakistan.
authors.forename: N
authors.initials: N
authors.lastname: Akhtar
authors.affiliation: Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan.
authors.forename: A
authors.initials: A
authors.lastname: Ali
mesh_terms: D000975:Antioxidants / Q000494:pharmacology; D001205:Ascorbic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D004355:Drug Stability; D004357:Drug Synergism; D004655:Emulsions / Q000494:pharmacology; D005145:Face; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D012629:Sebum / Q000187:drug effects* / Q000378:metabolism; D016037:Single-Blind Method; D012867:Skin / Q000187:drug effects*; D017592:Skin Care / Q000379:methods*
chemical_list: D000975:Antioxidants; D004655:Emulsions; C011669:ascorbate-2-phosphate; D001205:Ascorbic Acid; C031226:6-O-palmitoylascorbic acid