title: Two-dimensional metal-organic framework nanosheets as a matrix for laser desorption/ionization of small molecules and monitoring enzymatic reactions at high salt concentrations.
abstract: Stable 2-D metal-organic framework nanosheets were utilized as a superior clean-background matrix for MALDI-TOF MS analysis of small biomolecules and pollutants in both positive and negative ion modes. The matrix could unusually afford up to 1000 mM of the salt concentrations in the monitoring of the enzymatic hydrolysis of neurotransmitter acetylcholine.
authors.affiliation: College of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China. guzhiyuan@njnu.edu.cn.
authors.forename: Hai-Long
authors.initials: HL
authors.lastname: Liu
authors.affiliation: College of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China. guzhiyuan@njnu.edu.cn.
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Chang
authors.affiliation: College of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China. guzhiyuan@njnu.edu.cn.
authors.forename: Ting
authors.initials: T
authors.lastname: Fan
authors.affiliation: College of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China. guzhiyuan@njnu.edu.cn.
authors.forename: Zhi-Yuan
authors.identifier: http://orcid.org/0000-0002-6245-4759
authors.initials: ZY
authors.lastname: Gu