title: Kidney injury molecule-1 in kidney disease.
abstract: Kidney injury molecule-1(KIM-1) is a type I membrane protein, comprising an extracellular portion and a cytoplasmic portion, which is expressed at very low levels in the normal kidney. The extracellular portion can cleave and rapidly enter tubule lumens after kidney injury, and can then be detected in the urine. It has been confirmed that the urine KIM-1 level is closely related to tissue KIM-1 level and correlated with kidney tissue damage. Not only is KIM-1 proven to be an early biomarker of acute kidney injury but it also has a potential role in predicting long-term renal outcome. This review summarizes the relationships between KIM-1 and kidney injury, especially in chronic kidney disease.
authors.affiliation: a Department of Nephrology , The First Affiliated Hospital of Nanjing Medical University , Nanjing , Jiangsu Province , People's Republic of China.
authors.forename: Caixia
authors.initials: C
authors.lastname: Yin
authors.affiliation: a Department of Nephrology , The First Affiliated Hospital of Nanjing Medical University , Nanjing , Jiangsu Province , People's Republic of China.
authors.forename: Ningning
authors.initials: N
authors.lastname: Wang
mesh_terms: D058186:Acute Kidney Injury / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers / Q000652:urine; D000072596:Hepatitis A Virus Cellular Receptor 1 / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D051379:Mice; D051436:Renal Insufficiency, Chronic / Q000378:metabolism*
chemical_list: D015415:Biomarkers; C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1
keywords: Acute kidney injury; biomarker; chronic kidney disease; kidney injury molecule-1