title: Common variants in the chromosome 2p23 region containing the SLC30A3 (ZnT3) gene are associated with schizophrenia in female but not male individuals in a large collection of European samples.
abstract: Previously, we found a significant gender-specific association of schizophrenia, in a UK case/control study, with SLC30A3, a candidate that is consistently down-regulated in schizophrenia in two independent cohorts. In view of the potential significance of this finding, we extended this study to a larger cohort using GWAS data from the Psychiatric Genetic Consortium (PGC). Meta-analysis was performed for the only two SLC30A3 SNP variants (rs11126936 and rs11126929) available in most PGC cohorts. A significant association with schizophrenia was found for both variants. When meta-analysis was performed in male and female case-control subsets, an increased and gender-specific effect of allele on risk of disease was found in females for both SNPs with no significant effect in males, which was further associated with a gender-specific effect on gene expression. In conclusion, using a large European-wide sample we were able to replicate the gender-specific association previously found in a UK cohort.
authors.affiliation: Neurogenetics Group, Division of Brain Sciences, Faculty of Medicine, Imperial College London, UK. Electronic address: c.perez06@imperial.ac.uk.
authors.forename: C
authors.initials: C
authors.lastname: Perez-Becerril
authors.affiliation: Neurogenetics Group, Division of Brain Sciences, Faculty of Medicine, Imperial College London, UK. Electronic address: a.morris@imperial.ac.uk.
authors.forename: A G
authors.initials: AG
authors.lastname: Morris
authors.affiliation: University of Hull and NAViGO, Hull, UK. Electronic address: ann.mortimer@nhs.net.
authors.forename: A
authors.initials: A
authors.lastname: Mortimer
authors.affiliation: Benito Menni Complex Assistencial en Salut Mental, Germanes Hospitalàries del Sagrat Cor de Jesús, C/Doctor Antoni Pujades 38-C, 08830 Sant Boi de Llobregat Barcelona, Spain. Electronic address: pmckenna@fidmag.com.
authors.forename: P J
authors.initials: PJ
authors.lastname: McKenna
authors.affiliation: Neurogenetics Group, Division of Brain Sciences, Faculty of Medicine, Imperial College London, UK. Electronic address: j.belleroche@imperial.ac.uk.
authors.forename: J
authors.initials: J
authors.lastname: de Belleroche
mesh_terms: D016022:Case-Control Studies; D027682:Cation Transport Proteins / Q000235:genetics*; D005060:Europe; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000235:genetics*; D012737:Sex Factors
chemical_list: D027682:Cation Transport Proteins; C102806:SLC30A3 protein, human
keywords: Gender specificity; Meta-analysis of GWAS; SLC30A3; Schizophrenia; Zinc transporter 3 (ZNT3)